# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- adh_short PF00106.25 EFC35186.1 - 7.2e-27 94.1 0.6 8.1e-27 94.0 0.6 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC35186.1 - 1e-21 77.6 0.1 1.1e-21 77.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC35186.1 - 4.1e-08 33.4 0.1 4.4e-08 33.2 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC35186.1 - 2.2e-05 24.0 0.2 2.5e-05 23.9 0.2 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC35186.1 - 0.00025 20.3 0.1 0.00048 19.4 0.1 1.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Baculo_VP39 PF04501.12 EFC35186.1 - 0.0033 17.0 0.4 0.0053 16.3 0.4 1.3 1 1 0 1 1 1 1 Baculovirus major capsid protein VP39 Sacchrp_dh_NADP PF03435.18 EFC35186.1 - 0.0048 17.1 0.1 0.0059 16.9 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFC35186.1 - 0.011 15.7 0.1 0.014 15.3 0.1 1.1 1 0 0 1 1 1 0 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFC35186.1 - 0.013 14.7 0.3 0.022 13.9 0.1 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain LcrV PF04792.12 EFC35186.1 - 0.014 14.7 1.2 0.018 14.4 1.2 1.1 1 0 0 1 1 1 0 V antigen (LcrV) protein GDP_Man_Dehyd PF16363.5 EFC35186.1 - 0.053 12.9 0.1 0.082 12.3 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF3074 PF11274.8 EFC35188.1 - 2.1e-05 24.6 0.1 3e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) START PF01852.19 EFC35188.1 - 0.0035 16.8 0.0 0.0046 16.4 0.0 1.3 1 0 0 1 1 1 1 START domain Tweety PF04906.13 EFC35189.1 - 0.0042 15.8 1.4 0.0052 15.5 1.4 1.2 1 0 0 1 1 1 1 Tweety DUF2207 PF09972.9 EFC35189.1 - 0.0046 15.8 2.4 0.0062 15.3 2.4 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 EFC35189.1 - 0.058 13.7 0.2 0.058 13.7 0.2 2.2 1 1 1 2 2 2 0 Orf78 (ac78) PHO4 PF01384.20 EFC35189.1 - 0.14 11.2 3.3 0.18 10.9 3.3 1.1 1 0 0 1 1 1 0 Phosphate transporter family SieB PF14163.6 EFC35189.1 - 1 8.8 10.3 0.53 9.8 2.3 2.3 1 1 1 2 2 2 0 Super-infection exclusion protein B DUF3810 PF12725.7 EFC35189.1 - 1.2 8.4 5.3 1.7 7.9 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Glycophorin_A PF01102.18 EFC35189.1 - 3.1 8.1 17.0 0.51 10.6 2.4 2.5 1 1 1 2 2 2 0 Glycophorin A Wzy_C PF04932.15 EFC35189.1 - 9 5.9 10.3 18 4.9 10.3 1.5 1 1 0 1 1 1 0 O-Antigen ligase Shisa PF13908.6 EFC35189.1 - 9.1 6.5 13.5 0.27 11.5 1.5 2.4 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Pkinase PF00069.25 EFC35190.1 - 5.3e-21 75.2 0.0 6.7e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35190.1 - 2.7e-13 49.8 0.0 3.3e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ald_Xan_dh_C2 PF02738.18 EFC35192.1 - 7.8e-17 60.9 0.0 9.2e-17 60.7 0.0 1.0 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Macro PF01661.21 EFC35193.1 - 1.6e-32 112.0 0.1 2.1e-32 111.6 0.1 1.1 1 0 0 1 1 1 1 Macro domain NHL PF01436.21 EFC35194.1 - 1.4e-19 69.1 0.7 0.00017 21.4 0.1 5.9 5 0 0 5 5 5 4 NHL repeat EGF_2 PF07974.13 EFC35194.1 - 2.2e-14 53.5 43.9 3.8e-05 24.0 12.2 3.4 3 0 0 3 3 3 3 EGF-like domain EGF PF00008.27 EFC35194.1 - 8.7e-08 32.3 23.0 0.00045 20.5 2.7 3.5 3 0 0 3 3 3 2 EGF-like domain hEGF PF12661.7 EFC35194.1 - 0.00024 21.6 35.2 0.0062 17.1 5.9 4.0 3 0 0 3 3 3 2 Human growth factor-like EGF potato_inhibit PF00280.18 EFC35194.1 - 0.14 12.9 0.1 0.55 10.9 0.0 1.9 2 0 0 2 2 2 0 Potato inhibitor I family NHL PF01436.21 EFC35195.1 - 2.8e-06 27.1 0.0 0.045 13.8 0.0 2.5 2 0 0 2 2 2 2 NHL repeat SGL PF08450.12 EFC35195.1 - 0.002 17.7 0.0 0.1 12.2 0.0 2.0 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Yip1 PF04893.17 EFC35197.1 - 0.0094 15.7 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 1 Yip1 domain TMEM154 PF15102.6 EFC35197.1 - 0.026 14.4 2.4 0.046 13.6 2.4 1.5 1 1 0 1 1 1 0 TMEM154 protein family Orf78 PF06024.12 EFC35197.1 - 0.054 13.8 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Med12-PQL PF12144.8 EFC35197.1 - 0.083 12.8 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic Mediator 12 catenin-binding domain TMF_DNA_bd PF12329.8 EFC35198.1 - 0.25 11.3 4.7 0.97 9.5 4.7 2.0 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding LRR_6 PF13516.6 EFC35200.1 - 0.0016 18.3 3.0 0.89 9.8 0.1 3.1 3 0 0 3 3 3 2 Leucine Rich repeat LRR_2 PF07723.13 EFC35200.1 - 0.024 15.3 2.6 16 6.4 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_4 PF12799.7 EFC35200.1 - 1.8 9.1 7.2 8.9 6.9 0.1 3.8 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) Orn_DAP_Arg_deC PF00278.22 EFC35201.1 - 4.6e-27 94.1 0.0 6.8e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain EGF_2 PF07974.13 EFC35202.1 - 0.00017 21.9 27.6 0.00022 21.5 5.1 2.8 3 0 0 3 3 3 2 EGF-like domain EGF PF00008.27 EFC35202.1 - 0.043 14.1 2.7 0.043 14.1 2.7 3.7 4 0 0 4 4 4 0 EGF-like domain GST_C PF00043.25 EFC35204.1 - 4e-10 39.8 0.2 1.4e-09 38.1 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC35204.1 - 5.9e-07 29.6 0.6 1.1e-06 28.7 0.6 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC35204.1 - 2.8e-05 24.0 0.0 5.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC35204.1 - 8.4e-05 22.8 0.1 0.00016 21.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC35204.1 - 0.00023 21.5 0.0 0.00045 20.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFC35204.1 - 0.077 13.3 0.5 0.55 10.6 0.5 2.2 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Thioredoxin_8 PF13905.6 EFC35204.1 - 0.22 11.8 3.5 0.13 12.6 0.5 2.1 2 1 0 2 2 2 0 Thioredoxin-like EGF_2 PF07974.13 EFC35205.1 - 1e-12 48.2 100.9 0.00042 20.6 10.2 7.8 7 1 1 8 8 8 6 EGF-like domain Laminin_EGF PF00053.24 EFC35205.1 - 7.2e-06 26.0 78.9 0.12 12.5 15.6 5.8 1 1 4 5 5 5 3 Laminin EGF domain Zn-ribbon_8 PF09723.10 EFC35206.1 - 5.5e-16 58.4 0.3 8e-16 57.9 0.3 1.3 1 0 0 1 1 1 1 Zinc ribbon domain DUF1178 PF06676.11 EFC35206.1 - 0.021 15.2 0.5 0.027 14.8 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) zf-ACC PF17848.1 EFC35206.1 - 0.029 14.4 1.2 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Zn_ribbon_SprT PF17283.2 EFC35206.1 - 0.036 14.0 1.0 0.66 9.9 0.1 2.1 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DZR PF12773.7 EFC35206.1 - 0.036 14.1 0.5 0.058 13.4 0.5 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EFC35206.1 - 0.077 12.4 2.9 0.98 8.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF1451 PF07295.11 EFC35206.1 - 0.1 12.6 0.2 0.14 12.2 0.2 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain A2L_zn_ribbon PF08792.10 EFC35206.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 1 0 1 1 1 0 A2L zinc ribbon domain HypA PF01155.19 EFC35206.1 - 0.17 11.9 0.1 0.22 11.6 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-IS66 PF13005.7 EFC35206.1 - 0.17 12.3 0.7 9.8 6.7 0.1 2.2 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 TFIIS_C PF01096.18 EFC35206.1 - 0.23 11.3 1.0 13 5.8 0.1 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-NADH-PPase PF09297.11 EFC35206.1 - 0.46 10.2 3.9 8.1 6.2 0.3 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 EFC35206.1 - 0.88 9.4 4.9 3.1 7.7 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon domain MSA-2c PF12238.8 EFC35206.1 - 2.1 8.3 5.4 2.1 8.3 5.4 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c ApoC-I PF04691.12 EFC35208.1 - 0.0072 16.2 2.6 2.4 8.2 0.1 3.1 3 0 0 3 3 3 2 Apolipoprotein C-I (ApoC-1) TnpV PF14198.6 EFC35208.1 - 0.22 11.5 2.9 0.27 11.2 0.4 2.1 1 1 1 2 2 2 0 Transposon-encoded protein TnpV COMPASS-Shg1 PF05205.12 EFC35208.1 - 0.39 11.5 6.2 0.32 11.7 4.3 1.8 1 1 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 DUF643 PF04867.12 EFC35208.1 - 4.2 8.0 8.2 14 6.3 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF643) PX PF00787.24 EFC35209.1 - 4.9e-05 23.3 0.0 8.7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 PX domain BTB_2 PF02214.22 EFC35210.1 - 1.7e-16 60.4 0.4 3.5e-16 59.3 0.3 1.5 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.28 EFC35210.1 - 6.8e-07 29.4 0.3 1.2e-06 28.7 0.3 1.3 1 0 0 1 1 1 1 SPRY domain DUF3464 PF11947.8 EFC35212.1 - 0.079 12.7 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 NHL PF01436.21 EFC35213.1 - 7.9e-13 47.7 0.3 0.00025 20.9 0.0 4.1 4 1 1 5 5 5 3 NHL repeat DUF2573 PF10835.8 EFC35213.1 - 0.21 11.9 0.0 1.8 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2573) BTB PF00651.31 EFC35216.1 - 4e-11 43.1 0.2 1.9e-10 40.9 0.0 2.0 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EFC35216.1 - 0.0015 18.6 0.1 0.0054 16.8 0.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch AXE1 PF05448.12 EFC35216.1 - 0.034 12.8 0.0 0.044 12.5 0.0 1.1 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF4116 PF13475.6 EFC35217.1 - 3e-27 94.1 17.1 4.2e-11 42.4 0.6 4.2 1 1 3 4 4 4 4 Domain of unknown function (DUF4116) 6PF2K PF01591.18 EFC35217.1 - 0.018 14.4 0.3 0.029 13.7 0.3 1.4 1 1 0 1 1 1 0 6-phosphofructo-2-kinase KxDL PF10241.9 EFC35218.1 - 0.0056 16.9 3.0 0.0056 16.9 3.0 3.9 2 1 2 4 4 4 2 Uncharacterized conserved protein HHH_8 PF14716.6 EFC35218.1 - 0.092 13.1 0.9 4.3 7.8 0.0 3.5 2 1 0 3 3 3 0 Helix-hairpin-helix domain SOAR PF16533.5 EFC35218.1 - 0.21 11.6 22.0 0.13 12.3 5.3 4.0 1 1 2 4 4 4 0 STIM1 Orai1-activating region FlaC_arch PF05377.11 EFC35218.1 - 0.83 10.1 28.8 2.4 8.6 0.7 5.5 3 2 2 5 5 5 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 EFC35218.1 - 0.88 10.1 18.4 4.2 7.9 0.4 5.1 2 1 3 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF5517 PF17639.2 EFC35218.1 - 1.3 9.4 13.3 0.13 12.6 1.0 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5517) Syntaxin-6_N PF09177.11 EFC35218.1 - 1.6 9.3 22.3 1.8 9.2 0.6 4.7 2 1 2 4 4 4 0 Syntaxin 6, N-terminal TMPIT PF07851.13 EFC35218.1 - 2.2 7.4 26.0 1.8 7.7 6.8 3.1 2 1 1 3 3 3 0 TMPIT-like protein Mod_r PF07200.13 EFC35218.1 - 4.3 7.4 31.5 0.15 12.2 5.7 3.6 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Seryl_tRNA_N PF02403.22 EFC35218.1 - 4.7 7.5 33.3 2.2 8.5 3.4 4.9 1 1 3 5 5 5 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 EFC35218.1 - 6.8 6.7 23.4 0.43 10.6 1.1 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EFC35218.1 - 8.4 7.1 18.7 10 6.8 1.8 4.5 3 2 2 5 5 4 0 SlyX CPSF100_C PF13299.6 EFC35219.1 - 1.9e-18 67.2 0.0 2.2e-18 67.0 0.0 1.0 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal STN PF07660.14 EFC35219.1 - 0.14 11.9 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Secretin and TonB N terminus short domain UPF0242 PF06785.11 EFC35220.1 - 0.00016 21.9 8.3 0.00016 21.9 8.3 2.4 2 1 1 3 3 2 1 Uncharacterised protein family (UPF0242) N-terminus Tropomyosin PF00261.20 EFC35220.1 - 0.00031 20.2 11.7 0.0079 15.6 3.1 2.3 2 0 0 2 2 2 2 Tropomyosin Baculo_PEP_C PF04513.12 EFC35220.1 - 0.0011 19.0 13.3 0.0085 16.1 6.2 2.7 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Leu_zip PF15294.6 EFC35220.1 - 0.0036 16.9 14.9 0.0036 16.9 14.9 2.3 2 1 1 3 3 2 1 Leucine zipper Apolipoprotein PF01442.18 EFC35220.1 - 0.0047 16.8 3.0 0.012 15.5 1.7 2.1 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Prefoldin_2 PF01920.20 EFC35220.1 - 0.0051 16.8 14.7 0.15 12.0 2.0 4.4 3 1 2 5 5 4 2 Prefoldin subunit FlaC_arch PF05377.11 EFC35220.1 - 0.01 16.2 20.6 0.37 11.2 2.2 4.8 1 1 4 5 5 4 0 Flagella accessory protein C (FlaC) TSC22 PF01166.18 EFC35220.1 - 0.012 15.9 8.2 0.021 15.1 1.9 3.0 3 0 0 3 3 2 0 TSC-22/dip/bun family STAT_alpha PF01017.20 EFC35220.1 - 0.013 15.4 4.6 0.013 15.4 4.6 2.4 1 1 1 2 2 2 0 STAT protein, all-alpha domain TEX13 PF15186.6 EFC35220.1 - 0.019 14.6 3.5 0.56 9.9 0.2 2.6 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family Mei5_like PF17021.5 EFC35220.1 - 0.032 14.3 6.9 0.12 12.5 5.2 2.6 1 1 1 2 2 2 0 Putative double-strand recombination repair-like bZIP_1 PF00170.21 EFC35220.1 - 0.032 14.3 3.6 0.032 14.3 3.6 4.0 2 1 1 3 3 3 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 EFC35220.1 - 0.033 14.3 14.1 0.72 9.9 3.4 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Fib_alpha PF08702.10 EFC35220.1 - 0.045 13.9 16.6 0.12 12.5 7.4 3.2 1 1 1 3 3 3 0 Fibrinogen alpha/beta chain family E2R135 PF11570.8 EFC35220.1 - 0.047 14.0 5.1 0.055 13.8 3.7 1.8 1 1 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF1664 PF07889.12 EFC35220.1 - 0.06 13.4 15.2 0.87 9.6 4.5 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF2205 PF10224.9 EFC35220.1 - 0.061 13.3 8.4 2.3 8.3 1.0 3.7 3 1 0 3 3 3 0 Short coiled-coil protein DUF4407 PF14362.6 EFC35220.1 - 0.076 12.4 3.4 0.16 11.3 3.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Nsp1_C PF05064.13 EFC35220.1 - 0.083 12.7 13.0 0.73 9.7 1.6 4.2 3 1 1 4 4 4 0 Nsp1-like C-terminal region DUF948 PF06103.11 EFC35220.1 - 0.091 13.0 9.7 0.46 10.8 0.4 3.6 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) GIT_CC PF16559.5 EFC35220.1 - 0.13 12.2 8.1 16 5.5 0.5 3.9 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor SlyX PF04102.12 EFC35220.1 - 0.13 12.9 1.5 11 6.8 0.0 3.2 3 2 0 3 3 2 0 SlyX DUF1640 PF07798.11 EFC35220.1 - 0.14 12.2 22.2 2.6 8.0 12.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DASH_Dam1 PF08653.10 EFC35220.1 - 0.15 11.9 8.5 0.29 11.0 0.5 3.6 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF16 PF01519.16 EFC35220.1 - 0.15 12.6 16.9 5.4 7.6 3.0 3.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 MRPL52 PF18699.1 EFC35220.1 - 0.15 12.3 4.2 0.3 11.3 0.2 2.7 1 1 1 2 2 2 0 Mitoribosomal protein mL52 Prominin PF05478.11 EFC35220.1 - 0.16 9.9 16.4 1 7.2 3.4 1.8 1 1 1 2 2 2 0 Prominin DUF5446 PF17522.2 EFC35220.1 - 0.21 11.8 5.7 1 9.6 0.5 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5446) LPP PF04728.13 EFC35220.1 - 0.22 12.0 14.3 3.4 8.1 0.2 4.7 3 2 0 3 3 3 0 Lipoprotein leucine-zipper PLAC9 PF15205.6 EFC35220.1 - 0.29 11.6 1.3 1.7 9.1 0.5 2.2 2 0 0 2 2 2 0 Placenta-specific protein 9 DivIC PF04977.15 EFC35220.1 - 0.29 10.9 9.8 1.2 8.9 0.8 3.5 2 1 2 4 4 4 0 Septum formation initiator DUF4164 PF13747.6 EFC35220.1 - 0.35 11.2 4.6 0.88 9.9 1.2 3.1 1 1 2 3 3 2 0 Domain of unknown function (DUF4164) DUF5344 PF17279.2 EFC35220.1 - 0.35 11.5 12.5 0.7 10.5 1.8 4.0 2 2 1 3 3 3 0 Family of unknown function (DUF5344) Prefoldin PF02996.17 EFC35220.1 - 0.37 10.7 11.6 1.2 9.1 1.1 3.7 2 1 1 3 3 3 0 Prefoldin subunit Syntaxin-6_N PF09177.11 EFC35220.1 - 0.51 10.9 16.6 4.2 8.0 2.3 4.2 2 1 0 3 3 3 0 Syntaxin 6, N-terminal YabA PF06156.13 EFC35220.1 - 0.58 10.8 19.1 2.7 8.7 2.9 3.9 1 1 3 4 4 4 0 Initiation control protein YabA BLOC1_2 PF10046.9 EFC35220.1 - 0.62 10.4 14.6 1.8 8.9 0.6 3.6 1 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 EFC35220.1 - 0.78 10.2 12.1 1.7 9.2 2.4 2.9 2 1 0 2 2 2 0 Cell division protein ZapB APG6_N PF17675.1 EFC35220.1 - 0.9 10.1 16.4 2.4 8.7 2.8 2.9 2 1 1 3 3 2 0 Apg6 coiled-coil region ApoLp-III PF07464.11 EFC35220.1 - 0.95 9.5 15.7 1.4 9.0 10.8 2.9 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) GerPC PF10737.9 EFC35220.1 - 1 9.4 8.2 1.7 8.6 7.1 2.1 2 1 0 2 2 1 0 Spore germination protein GerPC YojJ PF10372.9 EFC35220.1 - 1.3 9.1 6.0 16 5.7 0.3 3.3 1 1 2 3 3 3 0 Bacterial membrane-spanning protein N-terminus YlqD PF11068.8 EFC35220.1 - 1.4 9.3 9.0 3.3 8.1 2.0 2.5 1 1 1 2 2 2 0 YlqD protein DUF5082 PF16888.5 EFC35220.1 - 1.8 8.9 14.8 1.5 9.1 7.2 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) V_ATPase_I PF01496.19 EFC35220.1 - 1.8 6.4 13.3 2.1 6.2 1.9 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family PMEI PF04043.15 EFC35220.1 - 1.8 8.9 8.1 8.7 6.7 4.7 2.3 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Fez1 PF06818.15 EFC35220.1 - 1.9 8.9 16.9 2.1 8.8 4.1 2.3 1 1 1 2 2 2 0 Fez1 YtxH PF12732.7 EFC35220.1 - 1.9 9.1 8.4 53 4.4 8.4 3.0 1 1 0 1 1 1 0 YtxH-like protein DUF3644 PF12358.8 EFC35220.1 - 2.2 8.8 6.4 0.98 9.9 0.3 3.0 1 1 2 3 3 2 0 Protein of unknown function (DUF3644) COG5 PF10392.9 EFC35220.1 - 2.3 8.4 18.1 0.4 10.8 1.9 3.4 1 1 2 3 3 3 0 Golgi transport complex subunit 5 XhlA PF10779.9 EFC35220.1 - 3.5 7.9 19.0 8.3 6.7 2.0 4.5 3 1 1 4 4 4 0 Haemolysin XhlA SHE3 PF17078.5 EFC35220.1 - 3.6 7.2 25.4 1.1e+02 2.4 24.9 2.7 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Laminin_II PF06009.12 EFC35220.1 - 3.8 7.5 21.3 1.9 8.5 8.5 3.0 1 1 2 3 3 3 0 Laminin Domain II BST2 PF16716.5 EFC35220.1 - 4.9 7.8 11.9 7.7 7.2 2.0 3.4 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Swi5 PF07061.11 EFC35220.1 - 6.5 6.9 11.0 5 7.3 1.0 3.3 2 1 1 3 3 3 0 Swi5 Uso1_p115_C PF04871.13 EFC35220.1 - 6.9 7.1 17.8 6.9 7.1 11.0 2.8 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Bacillus_HBL PF05791.11 EFC35220.1 - 7.3 6.4 19.6 17 5.2 10.5 3.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF4600 PF15372.6 EFC35220.1 - 8.5 6.8 14.0 18 5.8 4.8 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4600) 2OG-FeII_Oxy PF03171.20 EFC35221.1 - 0.011 16.2 0.1 0.031 14.8 0.1 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Cupin_2 PF07883.11 EFC35221.1 - 0.042 13.6 0.0 0.095 12.4 0.0 1.5 1 0 0 1 1 1 0 Cupin domain FNIP_M PF14637.6 EFC35221.1 - 0.094 12.7 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain EMP70 PF02990.16 EFC35222.1 - 1.8e-51 175.4 16.5 1.8e-51 175.4 16.5 1.5 2 0 0 2 2 2 1 Endomembrane protein 70 Ald_Xan_dh_C2 PF02738.18 EFC35223.1 - 3e-58 197.6 0.0 3.5e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Phi-29_GP16_7 PF06720.11 EFC35223.1 - 0.092 12.6 0.1 0.32 10.8 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 DUF4116 PF13475.6 EFC35224.1 - 1.7e-07 30.9 2.0 9.5e-06 25.3 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4116) Ras PF00071.22 EFC35225.1 - 3.5e-08 33.2 0.1 4.7e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 Ras family AP_endonuc_2 PF01261.24 EFC35225.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel TauE PF01925.19 EFC35226.1 - 0.19 11.3 5.9 0.41 10.3 6.1 1.4 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE Phage_holin_3_6 PF07332.11 EFC35226.1 - 0.22 11.6 0.3 0.3 11.1 0.3 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 EFC35226.1 - 0.42 9.3 1.5 0.51 9.0 1.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2627 PF11118.8 EFC35226.1 - 0.8 10.3 4.3 10 6.8 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2627) DUF3040 PF11239.8 EFC35226.1 - 1.9 8.8 3.7 7.5 6.9 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) Sel1 PF08238.12 EFC35227.1 - 9.2e-27 92.9 4.4 5.7e-09 36.4 0.1 4.6 5 0 0 5 5 5 3 Sel1 repeat Sel1 PF08238.12 EFC35228.1 - 4.9e-21 74.7 17.2 0.0023 18.6 0.0 7.5 8 0 0 8 8 7 5 Sel1 repeat TPR_11 PF13414.6 EFC35228.1 - 2.5e-11 43.1 4.9 4.3e-09 35.9 0.2 4.8 4 1 0 4 4 4 1 TPR repeat TPR_6 PF13174.6 EFC35228.1 - 7e-11 42.0 9.3 1.4 9.7 0.0 7.6 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC35228.1 - 1.2e-08 34.4 35.6 7.9e-08 31.8 0.5 9.6 11 1 0 11 11 11 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC35228.1 - 3.3e-08 33.7 4.3 0.0014 18.8 0.0 6.7 6 2 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC35228.1 - 6.4e-08 32.1 29.5 1.1e-05 25.1 0.3 9.3 11 1 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC35228.1 - 1.9e-07 31.6 0.0 5.1e-05 23.8 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC35228.1 - 1.3e-06 28.0 1.3 0.81 9.9 0.0 5.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC35228.1 - 2e-06 27.8 13.1 0.00062 20.0 0.1 6.3 4 3 2 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC35228.1 - 5.2e-05 23.1 0.2 5.2e-05 23.1 0.2 6.9 10 0 0 10 10 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC35228.1 - 0.00044 20.8 0.0 0.17 12.8 0.0 4.4 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC35228.1 - 0.0032 17.9 5.9 0.45 11.1 0.1 4.4 4 1 2 6 6 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC35228.1 - 0.023 14.9 0.0 0.089 13.0 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC35228.1 - 0.023 14.9 14.8 0.06 13.6 0.2 5.1 3 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 EFC35228.1 - 0.044 13.2 0.0 0.078 12.4 0.0 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit TOM20_plant PF06552.12 EFC35228.1 - 0.1 12.3 0.1 1.2 8.8 0.0 2.5 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Fis1_TPR_C PF14853.6 EFC35228.1 - 0.11 12.5 0.3 0.11 12.5 0.3 3.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 EFC35228.1 - 0.15 11.6 3.3 0.36 10.3 0.1 3.1 4 0 0 4 4 4 0 SHNi-TPR PPR PF01535.20 EFC35228.1 - 0.19 12.0 1.5 34 5.0 0.0 4.7 6 0 0 6 6 5 0 PPR repeat SPO22 PF08631.10 EFC35228.1 - 0.2 11.1 3.3 3 7.2 0.2 3.3 3 1 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like Mis12 PF05859.12 EFC35229.1 - 2.1e-05 24.6 0.2 5.6e-05 23.2 0.1 1.8 2 0 0 2 2 2 1 Mis12 protein Endonuclease_7 PF02945.15 EFC35229.1 - 0.026 14.4 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 Recombination endonuclease VII JMY PF15871.5 EFC35229.1 - 0.031 13.6 0.1 0.14 11.4 0.0 1.9 1 1 1 2 2 2 0 Junction-mediating and -regulatory protein TetR_C_4 PF08359.11 EFC35229.1 - 0.042 14.0 0.1 0.23 11.6 0.1 2.1 1 1 1 2 2 2 0 YsiA-like protein, C-terminal region Dor1 PF04124.12 EFC35229.1 - 0.057 12.1 2.3 0.064 11.9 0.1 2.1 3 0 0 3 3 3 0 Dor1-like family mCpol PF18182.1 EFC35229.1 - 0.078 13.3 0.2 23 5.4 0.2 2.8 3 1 0 3 3 3 0 minimal CRISPR polymerase domain Phage_RpbA PF10789.9 EFC35229.1 - 0.096 12.8 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Phage RNA polymerase binding, RpbA DUF5476 PF17570.2 EFC35231.1 - 0.22 11.9 5.1 0.088 13.2 1.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5476) VHL PF01847.16 EFC35232.1 - 1.4e-06 28.1 0.0 7.8e-06 25.7 0.0 2.0 2 0 0 2 2 2 1 VHL beta domain NHL PF01436.21 EFC35233.1 - 9.5e-12 44.3 5.5 0.0016 18.4 0.3 4.6 4 0 0 4 4 4 4 NHL repeat SGL PF08450.12 EFC35233.1 - 2.3e-06 27.4 0.3 0.0014 18.3 0.1 3.3 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Retinal PF15449.6 EFC35234.1 - 0.022 12.6 5.5 0.024 12.5 5.5 1.0 1 0 0 1 1 1 0 Retinal protein Endostatin PF06482.11 EFC35234.1 - 0.86 9.0 9.2 1 8.8 9.2 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Ndc1_Nup PF09531.10 EFC35234.1 - 2.4 6.8 5.9 2.4 6.7 5.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup WD40 PF00400.32 EFC35235.1 - 3.9e-22 78.1 9.3 3.1e-05 24.6 0.2 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat PQQ_3 PF13570.6 EFC35235.1 - 1.1e-07 32.1 0.0 1.1 9.8 0.0 4.1 4 0 0 4 4 4 2 PQQ-like domain ANAPC4_WD40 PF12894.7 EFC35235.1 - 0.012 15.9 0.0 1.8 8.9 0.0 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC35235.1 - 0.016 14.2 0.0 0.068 12.1 0.0 1.8 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Tachylectin PF14517.6 EFC35235.1 - 0.043 13.3 0.1 0.073 12.6 0.1 1.4 1 1 0 1 1 1 0 Tachylectin BBS2_Mid PF14783.6 EFC35235.1 - 0.047 13.7 0.0 2.4 8.2 0.0 2.4 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EFC35235.1 - 0.048 12.3 0.0 0.063 11.9 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 LRR_4 PF12799.7 EFC35239.1 - 2.4e-24 85.0 23.7 8e-11 42.0 6.0 4.2 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC35239.1 - 1.5e-19 70.2 5.0 1.5e-14 53.8 1.9 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EFC35239.1 - 1.1e-14 54.0 22.3 2.4e-07 30.4 4.8 4.0 2 1 0 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 EFC35239.1 - 2.4e-06 27.2 18.5 0.017 15.1 0.3 6.1 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 EFC35239.1 - 0.00024 21.2 18.9 4 8.4 0.6 6.3 6 0 0 6 6 6 3 Leucine Rich Repeat FTHFS PF01268.19 EFC35240.1 - 1.1e-72 245.1 0.0 1.2e-72 244.9 0.0 1.0 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase ABC2_membrane_3 PF12698.7 EFC35241.1 - 0.31 10.1 28.7 0.54 9.3 27.5 1.8 1 1 1 2 2 2 0 ABC-2 family transporter protein C1_1 PF00130.22 EFC35242.1 - 0.0011 18.8 6.1 0.0017 18.2 6.1 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-Di19 PF05605.12 EFC35242.1 - 0.023 15.0 4.4 0.054 13.8 4.4 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding HypA PF01155.19 EFC35242.1 - 0.073 13.1 0.4 0.088 12.8 0.4 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zf_RING PF16744.5 EFC35242.1 - 0.22 11.6 3.4 0.39 10.9 3.4 1.4 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING-like PF08746.11 EFC35242.1 - 0.55 10.6 7.0 1.2 9.6 7.0 1.5 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 EFC35242.1 - 0.55 10.2 6.4 1.2 9.1 6.4 1.6 1 1 0 1 1 1 0 PHD-finger zf-ACC PF17848.1 EFC35242.1 - 0.91 9.6 6.0 0.58 10.3 0.6 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain NHL PF01436.21 EFC35244.1 - 1.5e-08 34.3 0.2 0.26 11.4 0.0 4.4 4 0 0 4 4 4 3 NHL repeat EGF_2 PF07974.13 EFC35244.1 - 8.6e-06 26.0 30.7 5.9e-05 23.4 7.4 3.3 3 0 0 3 3 3 2 EGF-like domain SGL PF08450.12 EFC35244.1 - 0.003 17.2 0.0 0.0045 16.6 0.0 1.5 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 EFC35244.1 - 0.088 13.5 5.0 0.088 13.5 5.0 4.0 4 1 0 4 4 4 0 Human growth factor-like EGF EGF PF00008.27 EFC35244.1 - 0.56 10.6 24.0 0.62 10.4 3.4 3.6 3 0 0 3 3 3 0 EGF-like domain DSL PF01414.19 EFC35244.1 - 2.9 8.2 21.9 1.9 8.8 3.4 2.3 1 1 1 2 2 2 0 Delta serrate ligand QWRF PF04484.12 EFC35245.1 - 0.05 13.3 4.4 0.076 12.7 4.4 1.2 1 0 0 1 1 1 0 QWRF family Macoilin PF09726.9 EFC35245.1 - 0.34 9.4 4.1 0.38 9.3 4.1 1.1 1 0 0 1 1 1 0 Macoilin family EGF_2 PF07974.13 EFC35246.1 - 1.1e-17 64.1 95.5 0.00014 22.2 12.4 6.7 6 0 0 6 6 6 6 EGF-like domain EGF PF00008.27 EFC35246.1 - 0.0072 16.6 66.6 0.12 12.7 6.0 7.0 6 1 0 6 6 6 5 EGF-like domain Ank_2 PF12796.7 EFC35247.1 - 5.5e-08 33.3 0.1 9.2e-08 32.6 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC35247.1 - 4.7e-05 23.5 0.0 0.034 14.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EFC35247.1 - 0.00015 22.1 0.0 0.36 11.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC35247.1 - 0.00068 20.1 0.0 0.0022 18.5 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC35247.1 - 0.013 15.8 0.1 0.037 14.4 0.1 1.8 1 1 0 1 1 1 0 Ankyrin repeats (many copies) DUF3862 PF12978.7 EFC35247.1 - 0.045 13.6 0.1 0.08 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3862) Syntaxin-6_N PF09177.11 EFC35248.1 - 0.0001 22.8 1.7 0.0001 22.8 1.7 2.3 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Apolipoprotein PF01442.18 EFC35248.1 - 0.00011 22.2 2.5 0.0002 21.3 2.5 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EFC35248.1 - 0.00011 22.2 11.9 0.00011 22.2 11.9 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Bacillus_HBL PF05791.11 EFC35248.1 - 0.00013 21.9 6.0 0.00025 20.9 6.0 1.4 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) BCAS2 PF05700.11 EFC35248.1 - 0.00018 21.3 3.2 0.0004 20.1 3.2 1.5 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) TssO PF17561.2 EFC35248.1 - 0.00054 20.1 9.0 0.0013 18.9 9.0 1.6 1 0 0 1 1 1 1 Type VI secretion system, TssO Fzo_mitofusin PF04799.13 EFC35248.1 - 0.00073 19.1 3.8 0.0015 18.1 3.8 1.5 1 0 0 1 1 1 1 fzo-like conserved region DUF4618 PF15397.6 EFC35248.1 - 0.0015 18.0 14.4 0.0015 18.0 14.4 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4618) DUF948 PF06103.11 EFC35248.1 - 0.0015 18.7 1.9 0.0053 17.0 1.9 2.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) KxDL PF10241.9 EFC35248.1 - 0.003 17.8 8.8 0.003 17.8 8.8 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein DivIC PF04977.15 EFC35248.1 - 0.0053 16.5 11.4 0.035 13.9 3.6 2.8 1 1 1 2 2 2 1 Septum formation initiator LPP PF04728.13 EFC35248.1 - 0.0075 16.6 5.0 0.044 14.2 0.6 2.9 1 1 1 2 2 2 1 Lipoprotein leucine-zipper Lectin_N PF03954.14 EFC35248.1 - 0.0077 16.0 2.6 0.018 14.8 2.6 1.7 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain DUF2461 PF09365.10 EFC35248.1 - 0.0078 16.2 4.2 0.084 12.8 2.7 2.4 1 1 1 2 2 2 1 Conserved hypothetical protein (DUF2461) CdvA PF18822.1 EFC35248.1 - 0.0085 15.9 14.6 0.0085 15.9 14.6 2.4 2 1 1 3 3 2 1 CdvA-like coiled-coil domain BLOC1_2 PF10046.9 EFC35248.1 - 0.011 16.0 7.7 0.029 14.6 7.7 1.7 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 EFC35248.1 - 0.011 15.7 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.6 EFC35248.1 - 0.012 14.3 17.6 0.015 14.0 17.6 1.1 1 0 0 1 1 1 0 AAA domain T3SSipB PF16535.5 EFC35248.1 - 0.015 15.8 3.2 0.015 15.8 3.2 1.7 2 0 0 2 2 1 0 Type III cell invasion protein SipB HIP1_clath_bdg PF16515.5 EFC35248.1 - 0.022 15.3 10.9 0.022 15.3 10.9 2.6 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF883 PF05957.13 EFC35248.1 - 0.023 15.3 4.4 0.13 12.9 4.4 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) FlaC_arch PF05377.11 EFC35248.1 - 0.025 15.0 17.4 1.2e+02 3.1 16.1 3.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) ApoO PF09769.9 EFC35248.1 - 0.029 14.3 0.4 0.096 12.6 0.2 1.9 1 1 1 2 2 2 0 Apolipoprotein O ACCA PF03255.14 EFC35248.1 - 0.03 14.2 6.7 0.03 14.2 6.7 1.9 2 1 0 2 2 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Fib_alpha PF08702.10 EFC35248.1 - 0.049 13.8 2.9 0.049 13.8 2.9 3.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4337 PF14235.6 EFC35248.1 - 0.062 13.4 11.5 0.032 14.3 9.2 1.8 1 1 1 2 2 1 0 Domain of unknown function (DUF4337) Tweety PF04906.13 EFC35248.1 - 0.078 11.6 0.5 0.11 11.2 0.5 1.3 1 0 0 1 1 1 0 Tweety NAAA-beta PF15508.6 EFC35248.1 - 0.12 12.7 4.9 4.1 7.8 1.5 3.8 2 1 3 5 5 5 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase DUF4407 PF14362.6 EFC35248.1 - 0.12 11.7 3.8 0.23 10.8 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hemagglutinin PF00509.18 EFC35248.1 - 0.12 10.7 6.7 0.19 10.1 6.7 1.2 1 0 0 1 1 1 0 Haemagglutinin DASH_Duo1 PF08651.10 EFC35248.1 - 0.12 12.1 4.9 0.27 11.0 0.6 2.5 1 1 1 2 2 2 0 DASH complex subunit Duo1 FlxA PF14282.6 EFC35248.1 - 0.15 12.0 12.4 0.06 13.3 7.5 2.6 2 1 0 2 2 2 0 FlxA-like protein Prominin PF05478.11 EFC35248.1 - 0.25 9.2 12.1 0.041 11.9 8.6 1.4 1 1 1 2 2 2 0 Prominin TPR_MLP1_2 PF07926.12 EFC35248.1 - 0.25 11.4 0.2 0.25 11.4 0.2 2.9 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 EFC35248.1 - 0.25 11.3 12.5 0.029 14.4 7.5 2.1 2 1 0 2 2 1 0 Laminin Domain II DUF1640 PF07798.11 EFC35248.1 - 0.34 10.9 16.5 0.85 9.6 16.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4446 PF14584.6 EFC35248.1 - 0.44 10.5 11.4 0.11 12.4 7.3 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF4446) Cob_adeno_trans PF01923.18 EFC35248.1 - 0.44 10.7 4.9 0.32 11.1 2.5 1.8 1 1 1 2 2 2 0 Cobalamin adenosyltransferase LMBR1 PF04791.16 EFC35248.1 - 0.51 9.2 7.1 0.6 9.0 7.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM184 PF15665.5 EFC35248.1 - 0.59 9.9 21.5 0.099 12.4 7.8 2.3 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B EMC3_TMCO1 PF01956.16 EFC35248.1 - 0.65 9.7 6.8 1.4 8.7 6.8 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like TMPIT PF07851.13 EFC35248.1 - 0.77 8.9 16.8 0.021 14.1 8.0 2.0 2 0 0 2 2 2 0 TMPIT-like protein AAA_23 PF13476.6 EFC35248.1 - 0.91 10.0 17.8 1.4 9.3 17.8 1.4 1 1 0 1 1 1 0 AAA domain V-SNARE PF05008.15 EFC35248.1 - 0.95 9.9 14.6 0.98 9.8 8.8 3.3 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF4795 PF16043.5 EFC35248.1 - 1 8.9 22.5 1.4 8.4 22.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Vps51 PF08700.11 EFC35248.1 - 1.3 9.2 13.2 0.87 9.7 8.4 2.8 2 1 0 2 2 2 0 Vps51/Vps67 YtxH PF12732.7 EFC35248.1 - 1.4 9.5 19.9 0.14 12.7 12.5 2.7 1 1 1 2 2 2 0 YtxH-like protein AAA_11 PF13086.6 EFC35248.1 - 1.7 8.3 15.8 1.4 8.6 14.7 1.3 1 1 0 1 1 1 0 AAA domain ZnuA PF01297.17 EFC35248.1 - 1.8 7.9 6.7 3.4 7.0 5.6 1.9 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic DASH_Dam1 PF08653.10 EFC35248.1 - 2.2 8.2 4.3 2.6 7.9 1.2 2.6 1 1 2 3 3 3 0 DASH complex subunit Dam1 DUF2730 PF10805.8 EFC35248.1 - 2.3 8.4 12.2 0.063 13.4 5.2 2.0 3 0 0 3 3 1 0 Protein of unknown function (DUF2730) FliP PF00813.20 EFC35248.1 - 2.6 7.9 10.2 11 5.8 0.1 2.1 1 1 1 2 2 2 0 FliP family DUF4199 PF13858.6 EFC35248.1 - 2.8 8.3 7.4 3.7 7.9 6.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) FmiP_Thoc5 PF09766.9 EFC35248.1 - 4.3 6.5 17.3 0.17 11.2 8.5 2.1 1 1 1 2 2 2 0 Fms-interacting protein/Thoc5 DAG_kinase_N PF14513.6 EFC35248.1 - 4.4 7.5 13.0 0.19 11.9 4.3 2.1 1 1 1 2 2 2 0 Diacylglycerol kinase N-terminus Spc7 PF08317.11 EFC35248.1 - 5.2 5.9 22.2 0.038 12.9 12.7 1.9 1 1 0 2 2 2 0 Spc7 kinetochore protein Vfa1 PF08432.10 EFC35248.1 - 5.5 7.3 18.9 0.39 11.0 7.9 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF724 PF05266.14 EFC35248.1 - 5.7 6.7 22.4 0.041 13.7 10.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF724) Phage_GPO PF05929.11 EFC35248.1 - 5.7 6.5 12.3 1.5 8.4 9.1 1.7 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3987 PF13148.6 EFC35248.1 - 5.7 5.8 9.0 0.6 9.1 4.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Allexi_40kDa PF05549.11 EFC35248.1 - 5.7 6.4 5.9 1.3 8.4 2.7 1.5 2 0 0 2 2 1 0 Allexivirus 40kDa protein DUF2203 PF09969.9 EFC35248.1 - 6.2 7.6 13.6 0.21 12.3 5.1 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) HAUS6_N PF14661.6 EFC35248.1 - 7.5 6.1 14.7 4.1 6.9 12.7 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Prefoldin PF02996.17 EFC35248.1 - 7.9 6.4 17.8 1.2 9.1 3.6 2.7 2 1 1 3 3 2 0 Prefoldin subunit YojJ PF10372.9 EFC35248.1 - 7.9 6.7 13.2 42 4.3 11.0 3.2 1 1 2 3 3 2 0 Bacterial membrane-spanning protein N-terminus CK2S PF15011.6 EFC35248.1 - 8.1 6.3 12.0 0.78 9.6 5.9 2.2 2 1 0 2 2 2 0 Casein Kinase 2 substrate Sel1 PF08238.12 EFC35249.1 - 4.4e-40 135.2 13.8 4.1e-11 43.2 0.1 5.1 5 0 0 5 5 5 5 Sel1 repeat Transpos_assoc PF13963.6 EFC35249.1 - 0.00043 20.5 0.4 0.76 10.1 0.0 3.4 2 2 1 3 3 3 1 Transposase-associated domain ANAPC3 PF12895.7 EFC35249.1 - 0.02 15.1 5.4 1.3 9.3 0.2 3.3 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFC35249.1 - 0.023 15.3 4.4 67 4.4 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC35249.1 - 0.034 14.2 0.5 17 5.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 EFC35249.1 - 0.048 13.1 2.7 0.87 9.0 0.4 2.4 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 EFC35249.1 - 0.057 13.5 11.6 2.6 8.4 0.1 4.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC35249.1 - 0.11 12.3 10.2 6.9 6.7 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Chorion_2 PF03964.15 EFC35249.1 - 0.36 11.7 4.4 5.1 8.0 1.3 2.9 1 1 2 3 3 3 0 Chorion family 2 TPR_8 PF13181.6 EFC35249.1 - 2.7 8.4 22.3 4.7 7.7 0.3 5.8 5 2 0 5 5 5 0 Tetratricopeptide repeat Peptidase_C1 PF00112.23 EFC35250.1 - 8.8e-19 68.5 3.8 1.4e-18 67.8 3.8 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC35250.1 - 0.00024 20.9 0.0 0.00047 20.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EFC35250.1 - 0.057 12.2 0.2 0.075 11.8 0.2 1.2 1 0 0 1 1 1 0 Peptidase C1-like family Ycf70 PF17382.2 EFC35250.1 - 0.097 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized Ycf70-like CDC45 PF02724.14 EFC35251.1 - 0.00039 18.8 24.1 0.00048 18.6 24.1 1.1 1 0 0 1 1 1 1 CDC45-like protein Borrelia_P83 PF05262.11 EFC35251.1 - 0.4 9.1 32.7 0.6 8.5 32.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein LMBR1 PF04791.16 EFC35251.1 - 0.81 8.5 8.8 0.98 8.2 8.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF5427 PF10310.9 EFC35251.1 - 1.6 7.6 22.5 2.2 7.1 22.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Neur_chan_memb PF02932.16 EFC35251.1 - 6.3 6.8 8.6 10 6.1 8.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 EFC35251.1 - 8 6.2 26.4 15 5.3 26.4 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Guanylate_cyc PF00211.20 EFC35253.1 - 1.2e-59 201.0 0.2 1.4e-59 200.8 0.2 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HNOBA PF07701.14 EFC35253.1 - 0.0057 16.1 0.2 0.0091 15.4 0.2 1.3 1 0 0 1 1 1 1 Heme NO binding associated DUF4045 PF13254.6 EFC35254.1 - 0.0075 16.0 36.2 0.082 12.5 18.3 3.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4045) Acylphosphatase PF00708.18 EFC35254.1 - 0.082 13.3 0.1 40 4.7 0.0 3.4 3 0 0 3 3 3 0 Acylphosphatase THB PF18362.1 EFC35254.1 - 0.11 12.1 0.6 15 5.2 0.1 3.9 5 0 0 5 5 5 0 Tri-helix bundle domain IL2 PF00715.17 EFC35255.1 - 0.011 15.7 1.0 0.011 15.7 1.0 1.8 2 1 0 2 2 2 0 Interleukin 2 RR_TM4-6 PF06459.12 EFC35255.1 - 1.5 8.6 15.6 1.7 8.4 15.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ANAPC1 PF12859.7 EFC35255.1 - 3.4 8.2 9.9 8.3 7.0 9.9 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 1 ALMT PF11744.8 EFC35255.1 - 5.7 5.7 10.4 7.4 5.3 10.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PFEMP PF03011.15 EFC35255.1 - 8.6 7.0 10.9 6 7.5 9.2 1.7 1 1 0 1 1 1 0 PFEMP DBL domain Ras PF00071.22 EFC35256.1 - 6.4e-41 139.7 0.7 8.8e-41 139.2 0.7 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC35256.1 - 1.7e-22 79.9 0.1 3.6e-22 78.8 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35256.1 - 5e-12 45.6 0.9 6.5e-12 45.3 0.9 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC35256.1 - 0.00014 21.4 0.2 0.00017 21.2 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC35256.1 - 0.00042 19.7 0.2 0.00051 19.5 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DNA_pol_E_B PF04042.16 EFC35256.1 - 0.012 14.9 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B PRORP PF16953.5 EFC35256.1 - 0.022 14.3 0.5 0.26 10.8 0.1 2.0 1 1 1 2 2 2 0 Protein-only RNase P DUF4364 PF14277.6 EFC35258.1 - 0.016 14.9 0.0 0.038 13.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) S-AdoMet_synt_C PF02773.16 EFC35259.1 - 3.8e-69 231.0 0.0 4.4e-69 230.8 0.0 1.0 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EFC35259.1 - 0.0071 16.6 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain 2OG-FeII_Oxy_3 PF13640.6 EFC35261.1 - 0.00012 22.9 0.0 0.0002 22.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RHH_1 PF01402.21 EFC35263.1 - 0.087 12.8 0.8 0.22 11.5 0.8 1.6 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family DUF3808 PF10300.9 EFC35265.1 - 0.00026 19.9 0.2 0.0003 19.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_14 PF13428.6 EFC35265.1 - 0.0047 17.6 0.1 31 5.7 0.0 3.5 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC35265.1 - 0.022 15.3 0.1 0.37 11.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1955 PF09205.10 EFC35265.1 - 0.029 14.1 0.3 0.034 13.9 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) TPR_6 PF13174.6 EFC35265.1 - 0.056 14.1 0.4 1.3 9.9 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_5 PF12688.7 EFC35265.1 - 0.1 12.8 0.1 0.22 11.8 0.1 1.4 1 1 0 1 1 1 0 Tetratrico peptide repeat LMBR1 PF04791.16 EFC35266.1 - 3.3 6.5 5.9 3.6 6.4 5.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein NHL PF01436.21 EFC35268.1 - 1.1e-21 75.7 2.0 7.4e-06 25.7 0.0 4.9 4 0 0 4 4 4 4 NHL repeat Peptidase_C107 PF17222.3 EFC35268.1 - 0.007 15.4 2.1 11 4.9 0.0 3.6 3 1 1 4 4 4 2 Viral cysteine endopeptidase C107 SGL PF08450.12 EFC35268.1 - 0.0084 15.7 0.2 1.7 8.2 0.0 2.6 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region ComGF PF15980.5 EFC35268.1 - 0.059 13.7 0.5 5.2 7.5 0.0 3.2 4 0 0 4 4 4 0 Putative Competence protein ComGF Linker_histone PF00538.19 EFC35268.1 - 0.49 10.8 3.6 8.2 6.9 0.0 3.7 5 0 0 5 5 5 0 linker histone H1 and H5 family YdfZ PF14001.6 EFC35268.1 - 1.4 9.3 5.3 4.9 7.6 0.1 3.7 4 0 0 4 4 4 0 YdfZ protein LRR_6 PF13516.6 EFC35271.1 - 1.7e-26 90.0 14.9 0.0012 18.7 0.0 8.8 9 1 0 9 9 9 5 Leucine Rich repeat LRR_8 PF13855.6 EFC35271.1 - 1.6e-12 47.0 14.5 2.5e-06 27.1 0.7 3.9 2 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC35271.1 - 1.6e-12 47.4 21.3 0.00035 20.9 2.0 5.8 2 1 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35271.1 - 5e-06 26.3 13.2 3.1 8.7 0.1 7.1 7 1 0 7 7 7 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC35271.1 - 0.0003 20.3 1.6 0.076 12.5 0.1 2.5 1 1 2 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC35271.1 - 0.0037 17.1 0.1 10 5.9 0.0 4.2 1 1 3 4 4 4 1 Domain of unknown function (DUF4347) RNA_pol_I_TF PF04090.12 EFC35271.1 - 0.14 11.6 2.5 1.3 8.5 0.5 2.8 2 1 1 3 3 3 0 RNA polymerase I specific initiation factor Big_1 PF02369.16 EFC35272.1 - 0.038 14.0 4.8 0.12 12.4 3.7 2.1 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) LRR_6 PF13516.6 EFC35273.1 - 5.2e-54 175.7 1.7 1.4e-05 24.8 0.0 10.1 10 0 0 10 10 10 9 Leucine Rich repeat LRR_8 PF13855.6 EFC35273.1 - 3.6e-27 93.9 20.6 3.9e-07 29.7 0.2 5.0 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC35273.1 - 2.2e-25 88.3 10.7 5.7e-05 23.4 0.0 6.7 3 2 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35273.1 - 2.5e-15 54.7 0.0 9.3 7.2 0.0 10.3 11 0 0 11 11 11 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC35273.1 - 9.7e-05 21.9 0.9 0.21 11.1 0.2 3.3 1 1 4 5 5 5 3 Leucine-rich repeat Apo-VLDL-II PF05418.11 EFC35273.1 - 0.00072 20.1 0.3 40 4.9 0.0 4.4 2 1 3 5 5 5 0 Apovitellenin I (Apo-VLDL-II) ArenaCapSnatch PF17296.2 EFC35273.1 - 0.1 12.0 2.6 1.6 8.1 0.1 3.8 1 1 1 3 3 3 0 Arenavirus cap snatching domain Dynein_heavy PF03028.15 EFC35273.1 - 0.11 12.6 0.2 0.25 11.4 0.2 1.6 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain UPF0193 PF05250.11 EFC35273.1 - 0.28 11.0 7.2 3.1 7.5 0.2 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0193) Beta_helix PF13229.6 EFC35273.1 - 1.5 8.7 7.8 3.8 7.3 3.0 2.2 1 1 1 2 2 2 0 Right handed beta helix region TIR PF01582.20 EFC35274.1 - 0.079 12.8 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 TIR domain Guanylate_cyc PF00211.20 EFC35275.1 - 2.4e-28 99.0 0.0 4.4e-28 98.1 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC35275.1 - 5.9e-15 55.4 0.1 1.1e-14 54.5 0.1 1.5 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC35275.1 - 1.1e-08 35.0 0.0 2.3e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_10 PF13596.6 EFC35275.1 - 0.0076 16.8 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 PAS domain HNOBA PF07701.14 EFC35275.1 - 0.033 13.6 0.1 0.053 12.9 0.1 1.3 1 0 0 1 1 1 0 Heme NO binding associated PAS_8 PF13188.7 EFC35275.1 - 0.089 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 PAS domain PAS_2 PF08446.11 EFC35275.1 - 0.12 13.1 0.0 0.27 11.9 0.0 1.6 1 0 0 1 1 1 0 PAS fold Sgf11_N PF18519.1 EFC35275.1 - 0.44 10.1 1.8 3.5 7.3 0.2 2.6 2 0 0 2 2 2 0 SAGA-associated factor 11 N-terminal domain HATPase_c PF02518.26 EFC35277.1 - 2.5e-23 82.7 0.1 4.4e-23 81.9 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC35277.1 - 1.4e-15 57.5 0.1 3.5e-15 56.1 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC35277.1 - 3.2e-10 39.9 0.4 3.2e-10 39.9 0.4 2.3 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EFC35277.1 - 7.6e-06 25.8 1.9 0.00026 20.8 0.1 2.7 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EFC35277.1 - 0.00014 21.7 0.0 0.00028 20.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NHL PF01436.21 EFC35279.1 - 2.6e-24 84.0 0.8 4.7e-06 26.4 0.0 5.7 5 0 0 5 5 5 5 NHL repeat Str_synth PF03088.16 EFC35279.1 - 0.0084 16.2 0.2 20 5.4 0.0 4.1 5 0 0 5 5 5 1 Strictosidine synthase Linker_histone PF00538.19 EFC35279.1 - 0.033 14.5 0.2 48 4.4 0.0 3.7 3 1 0 3 3 3 0 linker histone H1 and H5 family Arylesterase PF01731.20 EFC35279.1 - 0.14 12.4 1.9 2.8 8.2 0.1 3.3 3 1 0 3 3 3 0 Arylesterase DUF1963 PF09234.10 EFC35280.1 - 8.6e-14 52.5 1.6 9.2e-14 52.4 0.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1963) CENP-B_dimeris PF09026.10 EFC35280.1 - 0.51 10.8 4.5 1.1 9.7 4.5 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain 2OG-FeII_Oxy_3 PF13640.6 EFC35281.1 - 1.2e-06 29.4 0.9 1.8e-06 28.7 0.2 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFC35281.1 - 8.9e-06 25.0 0.0 1.3e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Poxvirus C4/C10 protein Pkinase PF00069.25 EFC35282.1 - 1.9e-52 178.3 0.2 2.1e-52 178.1 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35282.1 - 2.5e-29 102.3 0.0 3.1e-29 102.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC35282.1 - 4.6e-06 25.8 2.0 9.9e-06 24.7 2.1 1.3 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC35282.1 - 2e-05 24.0 0.0 2.6e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFC35282.1 - 0.059 13.0 0.2 0.4 10.3 0.2 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HSP70 PF00012.20 EFC35283.1 - 8.3e-10 37.5 0.1 8.9e-10 37.4 0.1 1.0 1 0 0 1 1 1 1 Hsp70 protein PhoD PF09423.10 EFC35283.1 - 0.17 10.9 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 PhoD-like phosphatase zf-C3HC4 PF00097.25 EFC35284.1 - 7.9e-11 41.7 9.7 1.5e-10 40.7 9.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC35284.1 - 2.9e-10 39.8 6.6 4.5e-10 39.2 6.6 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC35284.1 - 1.6e-09 37.5 9.2 3e-09 36.5 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC35284.1 - 2.1e-09 37.2 7.1 4.6e-09 36.2 7.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFC35284.1 - 3.5e-09 36.7 10.0 7.2e-09 35.7 10.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFC35284.1 - 3.9e-09 36.3 8.5 6.1e-09 35.7 8.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFC35284.1 - 4.4e-09 36.5 11.0 7.1e-09 35.9 11.0 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFC35284.1 - 3.4e-06 26.8 6.8 6.8e-06 25.9 6.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFC35284.1 - 5.1e-05 23.5 7.6 0.00012 22.3 7.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain Baculo_IE-1 PF05290.11 EFC35284.1 - 0.00027 20.9 7.2 0.00034 20.6 6.6 1.5 1 1 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-ANAPC11 PF12861.7 EFC35284.1 - 0.0023 17.9 7.2 0.0044 17.0 7.2 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger U-box PF04564.15 EFC35284.1 - 0.021 15.0 0.6 0.13 12.4 0.0 2.5 2 1 1 3 3 3 0 U-box domain zf-RING_6 PF14835.6 EFC35284.1 - 0.035 14.0 4.2 0.079 12.8 4.2 1.5 1 1 0 1 1 1 0 zf-RING of BARD1-type protein GAGA PF09237.11 EFC35284.1 - 0.14 12.0 0.3 0.14 12.0 0.3 2.0 2 0 0 2 2 1 0 GAGA factor zf-MIZ PF02891.20 EFC35284.1 - 0.15 11.8 11.6 0.79 9.5 6.6 2.3 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_4 PF14570.6 EFC35284.1 - 2.2 8.2 8.5 5.9 6.8 8.4 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Presenilin PF01080.17 EFC35284.1 - 2.3 6.9 7.9 2.6 6.7 7.9 1.3 1 0 0 1 1 1 0 Presenilin Miga PF10265.9 EFC35284.1 - 4.3 6.2 14.3 4.9 6.0 13.6 1.4 1 1 0 1 1 1 0 Mitoguardin Macoilin PF09726.9 EFC35284.1 - 6.1 5.3 20.6 6.4 5.2 20.6 1.2 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 EFC35284.1 - 7 4.9 11.8 9.2 4.5 11.8 1.3 1 0 0 1 1 1 0 Menin DUF3053 PF11254.8 EFC35285.1 - 0.0076 15.9 0.0 0.0083 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3053) Csm1_N PF18504.1 EFC35285.1 - 0.028 14.8 1.4 0.028 14.8 1.4 2.1 2 1 0 2 2 2 0 Csm1 N-terminal domain DUF1477 PF07346.11 EFC35285.1 - 0.031 14.5 0.1 0.039 14.2 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1477) DBR1 PF05011.13 EFC35286.1 - 3.9 7.9 6.8 5.8 7.4 6.6 1.5 1 1 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain Ald_Xan_dh_C2 PF02738.18 EFC35289.1 - 7.4e-77 259.1 0.0 9.5e-45 153.1 0.0 2.6 1 1 1 2 2 2 2 Molybdopterin-binding domain of aldehyde dehydrogenase DUF2172 PF09940.9 EFC35291.1 - 0.014 15.7 0.3 8.9 6.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF2172) DUF4407 PF14362.6 EFC35292.1 - 0.014 14.7 5.0 0.02 14.2 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HCMV_UL139 PF12507.8 EFC35292.1 - 0.03 14.7 3.5 1 9.7 0.1 2.6 1 1 1 2 2 2 0 Human Cytomegalovirus UL139 protein MMR_HSR1 PF01926.23 EFC35292.1 - 0.032 14.3 1.7 0.047 13.8 0.0 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase Mt_ATP-synt_D PF05873.12 EFC35292.1 - 0.066 13.1 5.7 0.78 9.6 5.7 2.4 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) DUF4724 PF15852.5 EFC35292.1 - 0.088 13.3 1.5 0.15 12.6 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4724) Fib_alpha PF08702.10 EFC35292.1 - 0.15 12.3 10.2 0.12 12.6 8.2 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 EFC35292.1 - 1.1 8.7 13.0 0.39 10.3 10.1 1.6 1 1 1 2 2 2 0 Exonuclease VII, large subunit APG6_N PF17675.1 EFC35292.1 - 7 7.2 20.3 3 8.4 17.6 1.8 2 0 0 2 2 2 0 Apg6 coiled-coil region LRR_4 PF12799.7 EFC35293.1 - 0.0056 17.1 8.2 0.12 12.9 0.6 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC35293.1 - 0.0086 16.1 1.0 1.8 8.8 0.3 3.3 3 0 0 3 3 3 1 Leucine Rich repeat CLU_N PF15044.6 EFC35293.1 - 0.083 13.3 2.0 2.2 8.7 0.4 2.3 2 1 0 2 2 2 0 Mitochondrial function, CLU-N-term Sel1 PF08238.12 EFC35295.1 - 4.1e-52 173.4 36.3 2.3e-08 34.4 0.2 8.8 8 1 0 8 8 8 8 Sel1 repeat TPR_16 PF13432.6 EFC35295.1 - 0.00027 21.5 4.2 0.21 12.3 0.2 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC35295.1 - 0.00093 19.4 11.7 6.1 7.2 0.1 5.8 4 1 2 6 6 6 2 Tetratricopeptide repeat Raptor_N PF14538.6 EFC35295.1 - 0.015 15.2 1.3 0.99 9.4 0.6 2.8 1 1 1 3 3 3 0 Raptor N-terminal CASPase like domain TPR_20 PF14561.6 EFC35295.1 - 0.059 13.7 3.7 0.65 10.4 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC35295.1 - 0.12 12.5 6.7 0.34 11.1 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC35295.1 - 0.22 11.8 0.3 0.22 11.8 0.3 7.3 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC35295.1 - 0.61 9.8 22.4 8.8 6.1 0.1 6.6 6 2 0 6 6 6 0 TPR repeat TPR_6 PF13174.6 EFC35295.1 - 1.3 9.8 17.4 17 6.3 0.8 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC35295.1 - 1.3 9.3 32.7 0.38 11.0 0.3 8.4 9 1 1 10 10 10 0 Tetratricopeptide repeat MIT PF04212.18 EFC35295.1 - 2.2 8.4 18.3 10 6.3 0.3 5.5 5 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain MFS_1 PF07690.16 EFC35296.1 - 1.7e-23 83.1 1.3 2.2e-23 82.8 1.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC35296.1 - 7.7e-11 41.5 5.1 1.1e-10 41.0 4.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 EFC35296.1 - 1.1e-05 24.6 3.7 0.0023 16.8 0.1 2.3 1 1 1 2 2 2 2 MFS_1 like family MFS_3 PF05977.13 EFC35296.1 - 0.025 13.0 0.0 0.043 12.2 0.0 1.2 1 0 0 1 1 1 0 Transmembrane secretion effector Folate_carrier PF01770.18 EFC35296.1 - 0.052 12.3 7.0 0.014 14.1 0.4 2.6 2 1 0 2 2 2 0 Reduced folate carrier CRA PF06589.11 EFC35296.1 - 0.054 13.6 0.4 0.054 13.6 0.4 2.8 3 0 0 3 3 3 0 Circumsporozoite-related antigen (CRA) RNA_pol_Rpc4 PF05132.14 EFC35296.1 - 0.075 13.5 0.8 1.7 9.1 0.4 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF4634 PF15465.6 EFC35296.1 - 0.27 11.5 1.4 0.31 11.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4634) Peptidase_S46 PF10459.9 EFC35296.1 - 4.4 5.8 6.9 0.31 9.6 2.3 1.3 2 0 0 2 2 2 0 Peptidase S46 ETRAMP PF09716.10 EFC35296.1 - 4.6 7.4 5.9 0.77 9.9 1.1 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ADP_ribosyl_GH PF03747.14 EFC35297.1 - 3.8e-20 72.8 0.0 4.5e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase SAP130_C PF16014.5 EFC35298.1 - 0.055 12.6 1.5 0.059 12.5 1.5 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus NST1 PF13945.6 EFC35298.1 - 0.18 11.9 4.1 0.21 11.7 4.1 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF5041 PF16444.5 EFC35299.1 - 0.065 13.5 4.0 0.11 12.7 4.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5041) NYD-SP28 PF14772.6 EFC35299.1 - 2.5 8.2 10.0 0.72 9.9 6.3 2.1 2 0 0 2 2 2 0 Sperm tail 30K_MP_C_Ter PF11330.8 EFC35300.1 - 0.052 12.9 0.3 0.07 12.5 0.3 1.2 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins Peptidase_U4 PF03419.13 EFC35300.1 - 0.058 12.7 0.8 0.084 12.2 0.8 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Ifi-6-16 PF06140.13 EFC35301.1 - 2e-13 50.0 19.6 2e-13 50.0 19.6 1.7 1 1 1 2 2 2 1 Interferon-induced 6-16 family 2-Hacid_dh_C PF02826.19 EFC35301.1 - 0.053 12.9 0.0 0.071 12.5 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3568 PF12092.8 EFC35302.1 - 2.7 8.1 6.2 0.73 9.9 0.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3568) DUF4116 PF13475.6 EFC35303.1 - 8.5e-39 131.1 8.1 3e-11 42.9 0.1 5.8 2 2 4 6 6 6 6 Domain of unknown function (DUF4116) LRR_8 PF13855.6 EFC35307.1 - 3e-10 39.7 5.2 1e-07 31.6 1.3 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 EFC35307.1 - 8.8e-09 34.7 2.3 0.0076 16.2 0.1 4.5 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 EFC35307.1 - 1.6e-07 31.5 10.9 0.00032 21.0 3.1 3.5 1 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC35307.1 - 8.2e-05 22.2 2.4 0.00038 20.0 1.9 1.9 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFC35307.1 - 8.7e-05 22.6 2.1 1.3 9.9 0.0 4.2 4 1 0 4 4 4 2 Leucine Rich Repeat LOR PF04525.12 EFC35308.1 - 0.048 13.2 0.6 0.063 12.9 0.6 1.2 1 0 0 1 1 1 0 LURP-one-related Het-C PF07217.11 EFC35308.1 - 0.19 10.2 1.6 0.21 10.1 1.6 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C UPF0449 PF15136.6 EFC35308.1 - 0.2 12.2 5.6 0.32 11.5 5.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF3584 PF12128.8 EFC35308.1 - 0.3 8.6 8.5 1.8 6.0 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) CHD5 PF04420.14 EFC35308.1 - 0.39 10.6 6.3 0.58 10.0 6.3 1.5 1 1 0 1 1 1 0 CHD5-like protein GST_N PF02798.20 EFC35309.1 - 4.2e-06 27.0 0.0 7e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC35309.1 - 0.0018 18.7 0.0 0.0038 17.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC35309.1 - 0.025 14.8 0.0 0.044 14.0 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC35309.1 - 0.096 13.0 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain VEFS-Box PF09733.9 EFC35310.1 - 0.014 15.2 0.6 0.019 14.8 0.6 1.2 1 0 0 1 1 1 0 VEFS-Box of polycomb protein UBA_4 PF14555.6 EFC35310.1 - 0.016 15.0 0.1 0.03 14.1 0.0 1.5 2 0 0 2 2 2 0 UBA-like domain HypA PF01155.19 EFC35311.1 - 0.067 13.2 0.1 0.09 12.8 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Pro_isomerase PF00160.21 EFC35313.1 - 1.9e-50 171.2 0.3 2.1e-50 171.1 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EFC35313.1 - 0.0073 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain IQ PF00612.27 EFC35314.1 - 0.031 14.1 1.4 0.08 12.8 1.4 1.7 1 0 0 1 1 1 0 IQ calmodulin-binding motif AAA_assoc_C PF09821.9 EFC35314.1 - 0.12 13.0 8.5 0.082 13.5 2.6 2.5 2 0 0 2 2 2 0 C-terminal AAA-associated domain Pkinase PF00069.25 EFC35317.1 - 1.2e-14 54.4 1.3 3.2e-14 52.9 1.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35317.1 - 7.2e-14 51.7 1.9 3.2e-13 49.5 1.9 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC35317.1 - 0.0039 16.0 0.0 0.0066 15.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC35317.1 - 0.055 13.4 0.0 0.12 12.3 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family adh_short_C2 PF13561.6 EFC35318.1 - 1e-05 25.2 0.0 2.6e-05 23.9 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC35318.1 - 0.00014 21.4 0.2 0.00025 20.6 0.2 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Actin PF00022.19 EFC35319.1 - 5.6e-56 189.9 0.0 6.2e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC35319.1 - 0.023 13.5 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 MreB/Mbl protein BcrAD_BadFG PF01869.20 EFC35319.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family NAD_binding_10 PF13460.6 EFC35320.1 - 1.9e-11 44.2 0.0 2.3e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding HSP20 PF00011.21 EFC35321.1 - 9.7e-23 80.3 1.7 1.2e-22 80.0 1.7 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC35321.1 - 2.7e-05 23.6 0.0 3.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DUF4116 PF13475.6 EFC35322.1 - 7e-51 169.7 5.9 4.1e-15 55.2 0.2 5.7 2 1 1 5 5 5 5 Domain of unknown function (DUF4116) LRR_4 PF12799.7 EFC35323.1 - 7.2 7.2 13.9 1.7 9.2 0.6 4.6 5 3 0 5 5 5 0 Leucine Rich repeats (2 copies) Peptidase_S10 PF00450.22 EFC35324.1 - 1.5e-22 80.6 0.3 5.4e-22 78.8 0.0 1.8 2 0 0 2 2 2 1 Serine carboxypeptidase DUF4488 PF14869.6 EFC35325.1 - 0.0013 18.7 0.0 0.0036 17.2 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4488) CDC45 PF02724.14 EFC35325.1 - 0.053 11.8 20.5 0.088 11.1 20.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 EFC35325.1 - 0.6 8.2 28.3 1 7.5 28.3 1.3 1 0 0 1 1 1 0 Nop14-like family Nop53 PF07767.11 EFC35325.1 - 9.9 5.4 38.0 0.039 13.3 25.6 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) DUF3924 PF13062.6 EFC35326.1 - 0.0079 16.1 0.1 0.032 14.2 0.1 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3924) DUF3349 PF11829.8 EFC35326.1 - 0.015 16.0 3.8 0.16 12.7 0.7 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3349) WD40 PF00400.32 EFC35327.1 - 0.0016 19.3 0.1 0.0047 17.8 0.0 2.0 2 1 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC35327.1 - 0.04 14.2 0.0 0.063 13.6 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain p450 PF00067.22 EFC35328.1 - 2.5e-07 29.8 0.0 3e-07 29.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 zf-CCCH_4 PF18044.1 EFC35330.1 - 4.9e-07 29.4 5.8 7.2e-07 28.9 5.8 1.2 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFC35330.1 - 0.0007 19.6 10.8 0.0011 18.9 10.8 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EFC35330.1 - 0.0054 16.6 3.9 0.0087 16.0 3.9 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) CDC45 PF02724.14 EFC35330.1 - 0.052 11.8 26.1 0.066 11.5 26.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.13 EFC35330.1 - 0.068 11.7 21.0 0.11 11.0 21.0 1.3 1 0 0 1 1 1 0 Utp14 protein zf-UBP PF02148.19 EFC35330.1 - 0.084 13.2 1.3 0.084 13.2 1.3 2.0 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein SDA1 PF05285.12 EFC35330.1 - 0.1 12.0 35.8 0.13 11.6 35.8 1.0 1 0 0 1 1 1 0 SDA1 Torus PF16131.5 EFC35330.1 - 0.14 12.9 12.4 0.11 13.2 3.3 2.6 2 1 0 2 2 2 0 Torus domain Nop14 PF04147.12 EFC35330.1 - 0.15 10.3 30.7 0.17 10.0 30.7 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 EFC35330.1 - 3.6 6.8 31.7 4.9 6.4 31.7 1.2 1 0 0 1 1 1 0 BUD22 COPI_C PF06957.11 EFC35330.1 - 5.5 5.6 11.1 6.9 5.3 11.1 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF4607 PF15380.6 EFC35331.1 - 0.076 12.5 1.6 0.14 11.6 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4607) RNase_T PF00929.24 EFC35332.1 - 7.4e-15 55.9 0.0 8.9e-15 55.6 0.0 1.0 1 0 0 1 1 1 1 Exonuclease Toprim PF01751.22 EFC35334.1 - 0.03 14.5 0.0 0.076 13.2 0.0 1.7 1 0 0 1 1 1 0 Toprim domain CAP_C PF08603.11 EFC35336.1 - 1.1e-52 177.8 8.3 1.3e-52 177.6 8.3 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EFC35336.1 - 5.1e-05 23.0 5.4 8.3e-05 22.3 5.4 1.4 1 1 0 1 1 1 1 Tubulin binding cofactor C RisS_PPD PF16524.5 EFC35336.1 - 0.12 12.6 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS Aminotran_3 PF00202.21 EFC35337.1 - 6e-17 61.4 0.0 7.6e-17 61.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III 2OG-FeII_Oxy_3 PF13640.6 EFC35338.1 - 7.1e-07 30.0 0.0 1.7e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF505 PF04458.12 EFC35338.1 - 0.025 13.0 0.0 0.035 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) Glucokinase PF02685.16 EFC35338.1 - 0.074 12.0 0.0 0.21 10.6 0.0 1.6 1 1 1 2 2 2 0 Glucokinase DUF4116 PF13475.6 EFC35339.1 - 8.2e-46 153.5 17.1 3.4e-13 49.1 0.3 8.9 3 2 7 10 10 10 8 Domain of unknown function (DUF4116) Actin PF00022.19 EFC35341.1 - 1.2e-55 188.8 0.0 1.3e-55 188.7 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC35341.1 - 0.0062 15.4 0.0 0.007 15.2 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Phage_integrase PF00589.22 EFC35343.1 - 0.04 13.7 0.0 0.39 10.5 0.0 2.0 2 0 0 2 2 2 0 Phage integrase family Ribosomal_S30 PF04758.14 EFC35344.1 - 1.3e-06 28.5 2.6 2.1e-06 27.8 0.0 2.4 2 0 0 2 2 2 1 Ribosomal protein S30 Med18 PF09637.10 EFC35345.1 - 0.023 14.6 0.1 0.031 14.1 0.1 1.1 1 0 0 1 1 1 0 Med18 protein HGTP_anticodon2 PF12745.7 EFC35345.1 - 0.15 11.5 0.9 0.22 11.0 0.9 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Asp-B-Hydro_N PF05279.11 EFC35346.1 - 0.12 12.4 10.6 0.15 12.1 10.6 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RR_TM4-6 PF06459.12 EFC35346.1 - 0.22 11.3 13.0 0.27 11.0 13.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XRN_M PF17846.1 EFC35346.1 - 7.4 5.4 10.6 9.1 5.1 10.6 1.2 1 0 0 1 1 1 0 Xrn1 helical domain ALMT PF11744.8 EFC35346.1 - 8.4 5.1 12.0 9.3 5.0 12.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter VWA_2 PF13519.6 EFC35347.1 - 0.00012 22.7 0.0 0.00018 22.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC35347.1 - 0.00018 21.8 0.0 0.00025 21.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain EGF_2 PF07974.13 EFC35348.1 - 1.5e-62 207.6 240.7 4.3e-06 27.0 8.4 15.4 15 0 0 15 15 15 15 EGF-like domain NHL PF01436.21 EFC35349.1 - 0.0003 20.7 0.0 4.2 7.6 0.0 3.8 3 0 0 3 3 3 2 NHL repeat PHtD_u1 PF16645.5 EFC35349.1 - 1.5 9.3 6.7 3.7 8.1 6.7 1.6 1 0 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein DUF563 PF04577.14 EFC35350.1 - 3.8e-37 128.4 1.0 6.3e-37 127.7 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Caenor_Her-1 PF09232.10 EFC35354.1 - 0.012 15.7 1.2 0.019 15.1 1.2 1.3 1 0 0 1 1 1 0 Caenorhabditis elegans Her-1 DarT PF14487.6 EFC35354.1 - 0.034 14.0 0.6 0.049 13.5 0.6 1.3 1 0 0 1 1 1 0 ssDNA thymidine ADP-ribosyltransferase, DarT Phage_GP20 PF06810.11 EFC35355.1 - 0.0045 16.8 2.6 0.011 15.5 0.7 2.3 3 0 0 3 3 3 1 Phage minor structural protein GP20 PI3K_P85_iSH2 PF16454.5 EFC35355.1 - 0.014 15.0 0.0 0.056 13.1 0.0 1.8 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain SKA2 PF16740.5 EFC35355.1 - 0.024 14.4 0.1 0.048 13.5 0.1 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Ad_cyc_g-alpha PF08509.11 EFC35356.1 - 0.039 13.7 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain Phage_T4_gp19 PF06841.12 EFC35357.1 - 0.0089 15.9 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 T4-like virus tail tube protein gp19 ATHILA PF03078.15 EFC35357.1 - 0.02 13.7 0.1 0.024 13.5 0.1 1.0 1 0 0 1 1 1 0 ATHILA ORF-1 family PI_PP_I PF18363.1 EFC35357.1 - 0.13 12.5 0.0 0.25 11.5 0.0 1.5 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain RGS PF00615.19 EFC35358.1 - 4.7e-18 65.6 4.7 7.1e-18 65.0 4.7 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Cluap1 PF10234.9 EFC35359.1 - 0.013 14.9 0.5 0.019 14.4 0.5 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 SpoIIP PF07454.11 EFC35360.1 - 0.026 14.0 0.1 0.036 13.5 0.1 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) IMCp PF12314.8 EFC35360.1 - 0.19 12.0 1.9 0.52 10.6 0.2 2.0 2 0 0 2 2 2 0 Inner membrane complex protein PHC2_SAM_assoc PF16616.5 EFC35361.1 - 0.038 14.8 5.2 0.042 14.6 5.2 1.1 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 DUF4364 PF14277.6 EFC35362.1 - 0.0095 15.7 0.8 0.018 14.8 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) Cdc13_OB4_dimer PF18233.1 EFC35362.1 - 0.045 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Cdc13 OB4 dimerization domain NTS PF15447.6 EFC35362.1 - 0.076 13.5 1.2 0.19 12.3 0.2 2.2 2 0 0 2 2 2 0 N-terminal segments of PfEMP1 7TM_GPCR_Srz PF10325.9 EFC35362.1 - 0.1 11.9 0.2 0.17 11.2 0.2 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz PAS_10 PF13596.6 EFC35362.1 - 1.8 9.2 5.1 2.2 8.9 2.7 2.2 1 1 1 2 2 2 0 PAS domain KRE1 PF17056.5 EFC35365.1 - 0.081 12.7 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Killer toxin-resistance protein 1 Macscav_rec PF03523.13 EFC35365.1 - 0.85 9.6 4.0 1.7 8.6 4.0 1.4 1 0 0 1 1 1 0 Macrophage scavenger receptor DUF4455 PF14643.6 EFC35366.1 - 0.0012 17.6 1.2 0.0017 17.1 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) IFT57 PF10498.9 EFC35366.1 - 0.0025 16.8 0.7 0.0033 16.5 0.7 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Snapin_Pallidin PF14712.6 EFC35366.1 - 0.0042 17.5 1.0 0.027 14.9 0.2 2.1 2 0 0 2 2 2 1 Snapin/Pallidin SesA PF17107.5 EFC35366.1 - 0.021 15.0 0.4 0.4 10.9 0.2 2.4 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF2207 PF09972.9 EFC35366.1 - 0.025 13.3 0.4 0.085 11.6 0.2 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4337 PF14235.6 EFC35366.1 - 0.033 14.3 0.0 0.078 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) APG6_N PF17675.1 EFC35366.1 - 0.043 14.4 2.7 0.066 13.7 2.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region HBM PF16591.5 EFC35366.1 - 0.045 13.2 0.4 0.18 11.2 0.1 1.9 2 0 0 2 2 2 0 Helical bimodular sensor domain FAM184 PF15665.5 EFC35366.1 - 0.056 13.2 1.2 0.13 12.1 1.2 1.5 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B DUF5082 PF16888.5 EFC35366.1 - 0.06 13.6 0.4 0.15 12.3 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) KxDL PF10241.9 EFC35366.1 - 0.06 13.6 2.3 0.63 10.4 0.5 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF4225 PF13988.6 EFC35366.1 - 0.096 12.2 2.7 0.24 10.9 1.2 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4225) TMPIT PF07851.13 EFC35366.1 - 0.11 11.7 1.1 0.2 10.9 0.3 1.6 1 1 1 2 2 2 0 TMPIT-like protein DUF1664 PF07889.12 EFC35366.1 - 0.13 12.3 1.2 1.7 8.7 0.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 EFC35366.1 - 0.16 12.4 1.6 15 6.0 0.1 3.1 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) PRD PF00874.20 EFC35366.1 - 0.2 12.0 1.0 0.41 11.0 0.2 1.9 2 0 0 2 2 2 0 PRD domain Mod_r PF07200.13 EFC35366.1 - 0.24 11.5 3.1 0.5 10.5 3.1 1.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein MIS13 PF08202.11 EFC35366.1 - 0.25 10.6 1.8 1.1 8.5 2.3 1.6 1 1 1 2 2 2 0 Mis12-Mtw1 protein family Occludin_ELL PF07303.13 EFC35366.1 - 1 10.1 4.9 7.6 7.3 1.7 2.2 1 1 1 2 2 2 0 Occludin homology domain Sel1 PF08238.12 EFC35367.1 - 1e-05 26.0 0.2 0.0002 21.9 0.0 2.6 3 0 0 3 3 3 1 Sel1 repeat ZZ PF00569.17 EFC35367.1 - 0.23 11.3 22.2 1.1 9.2 14.3 2.5 1 1 1 2 2 2 0 Zinc finger, ZZ type LRR_6 PF13516.6 EFC35368.1 - 8.5e-17 59.7 13.2 0.027 14.5 0.0 7.1 7 0 0 7 7 7 6 Leucine Rich repeat LRR_8 PF13855.6 EFC35368.1 - 1.5e-14 53.5 14.9 1.5e-06 27.8 1.7 4.1 4 0 0 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC35368.1 - 5.8e-13 48.8 22.2 0.0007 19.9 2.5 5.1 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35368.1 - 6.7e-08 32.0 11.9 3.1 8.7 0.0 6.8 7 0 0 7 7 7 4 Leucine Rich Repeat Vault_3 PF17795.1 EFC35369.1 - 0.02 14.9 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 Major Vault Protein Repeat domain DUF4065 PF13274.6 EFC35370.1 - 0.076 13.9 1.2 0.087 13.7 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4065) MTP18 PF10558.9 EFC35371.1 - 6.9e-49 166.1 8.7 8.2e-29 100.8 0.3 2.1 1 1 1 2 2 2 2 Mitochondrial 18 KDa protein (MTP18) Trp_syntA PF00290.20 EFC35372.1 - 0.14 11.0 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Tryptophan synthase alpha chain PRIMA1 PF16101.5 EFC35374.1 - 0.0057 16.7 5.4 0.0057 16.7 5.4 1.4 1 1 0 1 1 1 1 Proline-rich membrane anchor 1 Sarcoglycan_2 PF05510.13 EFC35374.1 - 0.024 13.4 0.7 0.024 13.4 0.7 1.1 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Halogen_Hydrol PF10112.9 EFC35374.1 - 0.03 14.3 0.0 0.032 14.3 0.0 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF3278 PF11683.8 EFC35374.1 - 0.037 14.1 0.3 0.047 13.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) SLATT_6 PF18169.1 EFC35374.1 - 0.078 12.6 0.5 0.093 12.3 0.5 1.3 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 EphA2_TM PF14575.6 EFC35374.1 - 0.12 13.3 0.4 0.19 12.6 0.4 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 EFC35374.1 - 0.14 12.4 3.7 0.19 12.0 3.6 1.4 1 1 0 1 1 1 0 Orf78 (ac78) Ras PF00071.22 EFC35375.1 - 7.3e-47 159.0 0.1 8.5e-47 158.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC35375.1 - 1.6e-19 70.3 0.0 2.5e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35375.1 - 2.4e-10 40.2 0.0 3e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EFC35375.1 - 0.033 13.7 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Ras PF00071.22 EFC35376.1 - 3.5e-19 69.0 0.4 4.2e-19 68.7 0.4 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC35376.1 - 5.9e-09 35.6 0.2 7.2e-09 35.3 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC35376.1 - 4.9e-08 33.2 0.1 9.4e-08 32.3 0.1 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC35376.1 - 1.1e-05 25.0 0.1 1.3e-05 24.9 0.1 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC35376.1 - 0.00046 20.1 0.4 0.0028 17.6 0.3 2.0 2 0 0 2 2 2 1 RsgA GTPase CbiA PF01656.23 EFC35376.1 - 0.0037 17.3 0.1 2.5 8.1 0.1 2.0 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 EFC35376.1 - 0.14 12.0 1.7 0.15 11.8 0.6 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein IGR PF09597.10 EFC35379.1 - 4.2e-25 87.6 0.6 4.2e-25 87.6 0.6 2.0 2 1 0 2 2 2 1 IGR protein motif TerB_N PF13208.6 EFC35379.1 - 0.012 15.3 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 TerB N-terminal domain GvpG PF05120.12 EFC35379.1 - 0.089 12.8 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Gas vesicle protein G Arf PF00025.21 EFC35380.1 - 5.3e-46 156.3 0.0 6e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC35380.1 - 1.2e-12 47.7 0.1 2.2e-12 46.8 0.1 1.4 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC35380.1 - 4.8e-09 36.5 0.0 7.6e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC35380.1 - 1.1e-08 34.8 0.0 1.3e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC35380.1 - 3.5e-07 29.7 1.7 0.00022 20.5 0.1 3.1 2 1 1 3 3 3 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC35380.1 - 3.9e-07 30.2 0.1 5.7e-07 29.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC35380.1 - 2.5e-05 23.7 0.0 3.5e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC35380.1 - 9.4e-05 22.0 0.7 0.0026 17.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFC35380.1 - 0.0034 17.1 0.2 0.0066 16.2 0.2 1.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EFC35380.1 - 0.0096 16.2 0.4 0.61 10.4 0.4 2.2 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EFC35380.1 - 0.012 15.2 0.2 0.045 13.3 0.2 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC35380.1 - 0.036 14.0 0.3 6 6.8 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase PEPCK_ATP PF01293.20 EFC35380.1 - 0.051 12.2 0.1 0.063 11.9 0.1 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA PF00004.29 EFC35380.1 - 0.098 13.1 0.0 0.15 12.5 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ACT PF01842.25 EFC35380.1 - 0.13 12.0 0.0 3.6 7.4 0.0 2.6 1 1 0 1 1 1 0 ACT domain Thymidylate_kin PF02223.17 EFC35380.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase Ependymin PF00811.18 EFC35381.1 - 0.0067 16.7 1.0 0.27 11.5 1.0 2.2 1 1 0 1 1 1 1 Ependymin 2OG-FeII_Oxy_3 PF13640.6 EFC35382.1 - 1.9e-10 41.5 0.1 3.5e-10 40.6 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SPT6_acidic PF14632.6 EFC35383.1 - 0.13 12.9 0.1 1.7 9.3 0.0 2.2 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Biotin_lipoyl PF00364.22 EFC35384.1 - 8.3e-16 57.6 0.0 3.7e-07 29.9 0.0 3.0 3 0 0 3 3 3 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFC35384.1 - 2.5e-07 30.4 0.0 0.00035 20.4 0.0 3.3 3 0 0 3 3 3 2 Biotin-lipoyl like PTS_EIIA_1 PF00358.20 EFC35384.1 - 0.015 15.1 0.0 0.23 11.2 0.0 2.7 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 GCV_H PF01597.19 EFC35384.1 - 0.073 13.0 0.0 4.3 7.2 0.0 2.2 2 0 0 2 2 2 0 Glycine cleavage H-protein NQRA PF05896.11 EFC35384.1 - 0.13 11.6 0.0 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) QRPTase_N PF02749.16 EFC35384.1 - 0.18 11.9 0.0 0.51 10.4 0.0 1.7 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain Pkinase PF00069.25 EFC35385.1 - 1e-27 97.2 0.8 1.2e-27 97.0 0.8 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35385.1 - 1.3e-18 67.3 0.0 1.5e-18 67.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC35385.1 - 8.6e-05 21.5 0.2 9.6e-05 21.3 0.2 1.1 1 0 0 1 1 1 1 Fungal protein kinase HSBP1 PF06825.12 EFC35385.1 - 0.022 14.6 0.1 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Heat shock factor binding protein 1 BTB PF00651.31 EFC35386.1 - 2.9e-11 43.6 0.4 8.3e-11 42.1 0.4 1.8 1 0 0 1 1 1 1 BTB/POZ domain Pkinase_Tyr PF07714.17 EFC35387.1 - 1.4e-08 34.3 0.0 2.2e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC35387.1 - 7.7e-06 25.5 0.0 1.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain FUSC-like PF12805.7 EFC35387.1 - 0.0062 15.6 0.4 0.0086 15.2 0.4 1.1 1 0 0 1 1 1 1 FUSC-like inner membrane protein yccS GFA PF04828.14 EFC35389.1 - 3.5 8.0 7.8 6.6 7.2 5.8 2.4 2 1 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme Ras PF00071.22 EFC35390.1 - 3.7e-41 140.4 0.1 6.6e-41 139.6 0.1 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC35390.1 - 1.7e-15 57.3 0.1 5.2e-15 55.7 0.1 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF4497 PF14924.6 EFC35390.1 - 0.056 13.9 0.1 0.13 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) PA26 PF04636.13 EFC35391.1 - 0.027 13.4 7.1 0.029 13.3 7.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GCK PF07802.11 EFC35391.1 - 0.16 12.4 1.2 0.58 10.6 0.0 2.3 2 1 0 2 2 2 0 GCK domain Neur_chan_memb PF02932.16 EFC35391.1 - 0.22 11.6 8.6 0.25 11.3 8.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 EFC35391.1 - 0.49 10.5 7.0 0.69 10.0 7.0 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Endostatin PF06482.11 EFC35391.1 - 0.59 9.5 6.0 0.64 9.4 6.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 EFC35391.1 - 0.61 9.1 9.5 0.74 8.8 9.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 EFC35391.1 - 0.87 7.6 11.3 1 7.4 11.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PARM PF17061.5 EFC35391.1 - 1 9.4 9.1 1.2 9.2 9.1 1.0 1 0 0 1 1 1 0 PARM SAGA-Tad1 PF12767.7 EFC35391.1 - 1.1 8.9 10.3 1.4 8.6 10.3 1.1 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Asp-B-Hydro_N PF05279.11 EFC35391.1 - 2.8 8.0 12.7 3.3 7.7 12.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Use1 PF09753.9 EFC35391.1 - 3.8 7.2 16.0 6.7 6.4 16.0 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 Presenilin PF01080.17 EFC35391.1 - 3.9 6.2 10.8 4.1 6.1 10.8 1.1 1 0 0 1 1 1 0 Presenilin TP53IP5 PF15331.6 EFC35391.1 - 4.2 7.4 12.9 5.1 7.2 12.9 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Sec62 PF03839.16 EFC35391.1 - 7.3 6.0 9.0 9.9 5.6 9.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Pkinase PF00069.25 EFC35393.1 - 6e-18 65.2 3.9 7.9e-18 64.8 3.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35393.1 - 2.8e-08 33.4 0.6 4.1e-08 32.8 0.6 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC35393.1 - 6.9e-05 21.8 0.7 0.0034 16.2 0.1 2.0 1 1 1 2 2 2 2 Fungal protein kinase UPF0167 PF03691.14 EFC35394.1 - 0.013 15.3 0.1 0.034 14.0 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) LOH1CR12 PF10158.9 EFC35394.1 - 0.057 13.4 0.4 0.16 12.0 0.4 1.7 1 0 0 1 1 1 0 Tumour suppressor protein DUF3853 PF12964.7 EFC35395.1 - 0.019 15.1 0.4 0.044 14.0 0.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3853) Tox-MPTase3 PF15639.6 EFC35395.1 - 0.086 12.7 0.9 0.24 11.3 0.2 2.0 3 0 0 3 3 3 0 Metallopeptidase toxin 3 Oxidored_FMN PF00724.20 EFC35397.1 - 0.0037 16.6 0.0 0.005 16.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Phage_integrase PF00589.22 EFC35398.1 - 4.2e-05 23.4 0.0 6.6e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family Ntox35 PF15534.6 EFC35400.1 - 0.045 14.2 0.3 0.62 10.5 0.0 2.8 3 0 0 3 3 3 0 Bacterial toxin 35 ASFV_J13L PF05568.11 EFC35401.1 - 0.00051 19.9 0.6 0.00087 19.1 0.6 1.3 1 0 0 1 1 1 1 African swine fever virus J13L protein TMEM154 PF15102.6 EFC35401.1 - 0.022 14.7 0.3 0.045 13.6 0.3 1.4 1 0 0 1 1 1 0 TMEM154 protein family Insulin_TMD PF17870.1 EFC35401.1 - 0.053 13.6 3.6 0.11 12.6 3.6 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF5385 PF17359.2 EFC35401.1 - 0.19 11.2 0.7 0.27 10.8 0.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) SKG6 PF08693.10 EFC35401.1 - 0.34 10.4 7.8 0.76 9.2 7.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain MJ1316 PF04457.12 EFC35402.1 - 1e-07 32.5 0.1 2e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Turandot PF07240.11 EFC35402.1 - 0.029 14.3 0.7 3 7.9 0.0 2.9 3 1 0 3 3 3 0 Stress-inducible humoral factor Turandot KdpC PF02669.15 EFC35402.1 - 0.14 12.0 0.4 0.25 11.2 0.4 1.4 1 0 0 1 1 1 0 K+-transporting ATPase, c chain BTB PF00651.31 EFC35403.1 - 1.9e-10 41.0 2.0 4.7e-10 39.7 0.6 2.1 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 EFC35403.1 - 4.9e-05 23.4 0.9 0.00072 19.6 0.9 2.6 1 1 0 1 1 1 1 BTB And C-terminal Kelch Cytochrom_NNT PF03264.14 EFC35404.1 - 0.017 14.8 8.3 0.3 10.8 3.2 2.1 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 EFC35404.1 - 0.13 12.2 10.3 4.1 7.5 2.9 3.1 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c HNH PF01844.23 EFC35404.1 - 0.16 12.2 17.4 0.41 10.8 0.2 4.5 5 0 0 5 5 5 0 HNH endonuclease Zn-ribbon_8 PF09723.10 EFC35404.1 - 1.7 8.8 5.7 12 6.1 0.2 3.2 3 0 0 3 3 3 0 Zinc ribbon domain YL1 PF05764.13 EFC35405.1 - 0.036 14.2 15.5 0.052 13.7 15.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 EFC35405.1 - 0.2 9.9 17.6 0.25 9.6 17.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4614 PF15391.6 EFC35405.1 - 0.22 11.5 10.7 0.4 10.7 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Zip PF02535.22 EFC35405.1 - 2.9 7.0 5.3 3.3 6.8 5.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MBDa PF16564.5 EFC35406.1 - 0.15 12.3 1.6 3.5 7.9 0.3 2.3 2 0 0 2 2 2 0 p55-binding region of Methyl-CpG-binding domain proteins MBD GluR_Homer-bdg PF10606.9 EFC35406.1 - 0.38 11.0 3.5 2.7 8.2 1.7 2.3 2 0 0 2 2 2 0 Homer-binding domain of metabotropic glutamate receptor DUF787 PF05619.11 EFC35407.1 - 0.4 9.8 3.3 0.67 9.0 0.1 2.0 1 1 1 2 2 2 0 Borrelia burgdorferi protein of unknown function (DUF787) Prefoldin_2 PF01920.20 EFC35408.1 - 4.4e-17 62.0 8.2 6.7e-17 61.4 8.2 1.3 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 EFC35408.1 - 2.7e-05 24.0 11.3 7e-05 22.7 2.6 2.4 3 0 0 3 3 2 2 Prefoldin subunit DUF3584 PF12128.8 EFC35408.1 - 0.0021 15.7 6.0 0.0025 15.4 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF4448 PF14610.6 EFC35408.1 - 0.017 14.9 0.5 0.019 14.8 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Hemagglutinin PF00509.18 EFC35408.1 - 0.026 12.9 8.7 0.028 12.8 8.7 1.1 1 0 0 1 1 1 0 Haemagglutinin Sec2p PF06428.11 EFC35408.1 - 0.03 14.3 8.1 0.04 13.9 2.0 2.2 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Sec34 PF04136.15 EFC35408.1 - 0.03 14.2 5.5 0.35 10.8 0.4 2.1 2 0 0 2 2 2 0 Sec34-like family PI3K_P85_iSH2 PF16454.5 EFC35408.1 - 0.032 13.8 7.7 1.2 8.7 3.2 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TRAP-delta PF05404.12 EFC35408.1 - 0.036 13.6 0.3 0.066 12.7 0.2 1.4 1 1 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) DASH_Dam1 PF08653.10 EFC35408.1 - 0.044 13.6 1.6 2 8.3 0.3 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 TssO PF17561.2 EFC35408.1 - 0.046 13.8 12.6 9.5 6.3 12.8 2.2 1 1 0 1 1 1 0 Type VI secretion system, TssO Fe-S_assembly PF04384.13 EFC35408.1 - 0.052 14.2 0.5 0.052 14.2 0.5 2.0 2 1 0 2 2 2 0 Iron-sulphur cluster assembly V_ATPase_I PF01496.19 EFC35408.1 - 0.059 11.3 5.7 0.065 11.1 5.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 EFC35408.1 - 0.064 11.9 8.3 0.11 11.1 8.1 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF4618 PF15397.6 EFC35408.1 - 0.073 12.5 7.9 0.64 9.4 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Effector_1 PF04518.12 EFC35408.1 - 0.081 12.0 5.7 0.034 13.3 2.4 1.7 1 1 1 2 2 2 0 Effector from type III secretion system Metal_resist PF13801.6 EFC35408.1 - 0.099 12.8 0.6 0.98 9.6 0.4 2.0 2 0 0 2 2 2 0 Heavy-metal resistance Spc24 PF08286.11 EFC35408.1 - 0.1 12.9 9.7 0.43 10.9 1.1 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 NYD-SP28 PF14772.6 EFC35408.1 - 0.12 12.4 11.8 0.93 9.6 3.4 2.1 2 0 0 2 2 2 0 Sperm tail Complex1_49kDa PF00346.19 EFC35408.1 - 0.12 11.4 0.3 0.16 11.1 0.3 1.1 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit BCAS2 PF05700.11 EFC35408.1 - 0.16 11.7 6.2 0.39 10.4 0.4 2.0 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) CdvA PF18822.1 EFC35408.1 - 0.24 11.2 11.2 0.61 9.9 4.9 2.3 1 1 1 2 2 2 0 CdvA-like coiled-coil domain AAA_lid_9 PF17871.1 EFC35408.1 - 0.25 11.3 5.5 1.3 8.9 0.7 2.3 2 1 0 2 2 2 0 AAA lid domain AAA_11 PF13086.6 EFC35408.1 - 0.27 11.0 3.9 0.37 10.5 3.9 1.2 1 0 0 1 1 1 0 AAA domain FliD_C PF07195.12 EFC35408.1 - 0.3 10.5 8.7 4.5 6.6 8.7 2.1 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus FlaC_arch PF05377.11 EFC35408.1 - 0.31 11.5 6.9 0.5 10.8 0.4 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3810 PF12725.7 EFC35408.1 - 0.31 10.3 2.6 0.24 10.7 0.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) DUF4140 PF13600.6 EFC35408.1 - 0.32 11.5 4.9 1.4 9.4 0.4 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF2935 PF11155.8 EFC35408.1 - 0.36 11.2 4.1 2.6 8.4 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) TPR_MLP1_2 PF07926.12 EFC35408.1 - 0.38 10.8 12.5 3.6 7.7 0.6 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein BST2 PF16716.5 EFC35408.1 - 0.44 11.2 10.2 1.4 9.6 1.3 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 PRKCSH-like PF12999.7 EFC35408.1 - 0.46 10.3 7.4 0.49 10.2 3.8 2.0 1 1 1 2 2 2 0 Glucosidase II beta subunit-like DUF4407 PF14362.6 EFC35408.1 - 0.48 9.7 6.3 0.78 9.0 6.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 EFC35408.1 - 0.55 10.5 12.5 2.3 8.5 0.6 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain bZIP_1 PF00170.21 EFC35408.1 - 0.62 10.2 11.7 0.12 12.4 1.0 2.4 2 0 0 2 2 2 0 bZIP transcription factor Fib_alpha PF08702.10 EFC35408.1 - 0.86 9.8 7.2 2.4 8.3 0.6 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family XhlA PF10779.9 EFC35408.1 - 0.88 9.8 8.9 5.2 7.4 2.2 2.4 2 0 0 2 2 2 0 Haemolysin XhlA PRP1_N PF06424.12 EFC35408.1 - 1.6 9.1 8.8 3.2 8.2 2.2 2.2 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal APG6_N PF17675.1 EFC35408.1 - 1.6 9.2 12.8 0.96 10.0 10.0 1.8 1 1 1 2 2 2 0 Apg6 coiled-coil region TMPIT PF07851.13 EFC35408.1 - 1.7 7.8 6.1 2.4 7.4 6.1 1.3 1 1 0 1 1 1 0 TMPIT-like protein FliD_N PF02465.18 EFC35408.1 - 2.6 8.8 8.8 4.1 8.2 1.6 2.4 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus SseC PF04888.12 EFC35408.1 - 3.8 7.0 5.5 1.3 8.5 2.2 1.7 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Calpain_III PF01067.22 EFC35409.1 - 0.00025 21.3 0.1 0.00052 20.3 0.1 1.4 1 1 0 1 1 1 1 Calpain large subunit, domain III EGF_2 PF07974.13 EFC35410.1 - 4e-37 126.2 292.6 0.00014 22.1 8.8 16.3 16 0 0 16 16 16 15 EGF-like domain EGF_Tenascin PF18720.1 EFC35410.1 - 1e-14 54.2 173.1 0.052 13.6 3.7 15.5 15 0 0 15 15 15 14 Tenascin EGF domain EB PF01683.18 EFC35410.1 - 1.4e-07 31.7 218.0 0.51 10.7 4.3 15.9 4 3 12 16 16 16 15 EB module MipA PF06629.12 EFC35411.1 - 0.012 15.9 0.2 0.015 15.5 0.2 1.2 1 0 0 1 1 1 0 MltA-interacting protein MipA DUF4812 PF16071.5 EFC35411.1 - 0.026 14.3 0.1 0.59 10.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4812) NHL PF01436.21 EFC35412.1 - 2.6e-09 36.7 0.0 1.1e-05 25.3 0.0 2.6 2 0 0 2 2 2 2 NHL repeat ANAPC4_WD40 PF12894.7 EFC35412.1 - 0.12 12.7 0.1 0.95 9.8 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4116 PF13475.6 EFC35413.1 - 1.1e-48 162.7 0.8 2.2e-17 62.5 0.0 4.3 1 1 4 5 5 5 5 Domain of unknown function (DUF4116) WD40 PF00400.32 EFC35414.1 - 8.9e-09 35.9 15.8 0.0001 23.0 0.3 6.1 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC35414.1 - 0.00066 19.9 6.4 1.4 9.3 0.1 4.9 2 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain HMG-CoA_red PF00368.18 EFC35416.1 - 1.3e-119 399.5 8.6 1.5e-119 399.3 8.6 1.0 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sugar_tr PF00083.24 EFC35417.1 - 1.2e-52 179.3 19.8 4.7e-30 104.9 3.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 EFC35417.1 - 3.7e-21 75.4 32.6 1.7e-16 60.1 16.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 EFC35417.1 - 0.00017 21.0 6.9 0.00049 19.5 2.1 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 EFC35417.1 - 0.0002 20.0 8.5 0.0012 17.3 2.3 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) TMEM70 PF06979.12 EFC35417.1 - 0.062 13.7 0.1 0.26 11.7 0.1 2.1 1 0 0 1 1 1 0 Assembly, mitochondrial proton-transport ATP synth complex DUF2933 PF11666.8 EFC35417.1 - 0.64 10.1 4.1 1.2 9.3 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2933) PIEZO PF15917.5 EFC35418.1 - 2.7 7.4 9.0 0.28 10.6 3.0 1.9 1 1 1 2 2 2 0 Piezo PARP_reg PF02877.14 EFC35419.1 - 6.5e-05 23.0 3.2 8.9e-05 22.6 2.4 1.7 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFC35419.1 - 0.00022 21.2 1.1 0.0025 17.8 0.3 2.8 2 1 0 2 2 2 1 WGR domain Phage_pRha PF09669.10 EFC35419.1 - 0.11 13.1 1.6 0.94 10.1 0.0 2.6 2 1 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Trm56 PF01994.16 EFC35419.1 - 0.12 12.3 0.6 18 5.3 0.1 2.4 1 1 1 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 Fib_alpha PF08702.10 EFC35419.1 - 3.8 7.7 7.7 11 6.1 0.0 2.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family FKBP_C PF00254.28 EFC35420.1 - 9.6e-34 115.6 0.0 1.1e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N_2 PF18023.1 EFC35420.1 - 0.15 12.2 0.0 0.77 9.9 0.0 1.9 1 1 0 1 1 1 0 BDBT FKBP like N-terminal Lysine_decarbox PF03641.14 EFC35424.1 - 8.5e-17 61.5 0.0 1.4e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFC35424.1 - 9e-13 48.1 0.0 9.3e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 SLOG cluster4 family C9orf72-like PF15019.6 EFC35424.1 - 0.046 13.3 0.3 0.071 12.7 0.3 1.2 1 0 0 1 1 1 0 C9orf72-like protein family DUF4116 PF13475.6 EFC35425.1 - 2e-49 165.1 30.4 3.2e-09 36.4 0.0 10.8 5 4 6 11 11 11 11 Domain of unknown function (DUF4116) Helitron_like_N PF14214.6 EFC35425.1 - 0.015 15.5 0.7 0.044 14.0 0.0 2.1 3 0 0 3 3 3 0 Helitron helicase-like domain at N-terminus FRG1 PF06229.12 EFC35425.1 - 0.63 9.7 3.3 1.8 8.3 2.2 2.2 2 0 0 2 2 2 0 FRG1-like domain GCK PF07802.11 EFC35426.1 - 0.066 13.6 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 GCK domain Polyketide_cyc2 PF10604.9 EFC35427.1 - 8.2e-20 71.5 0.0 1e-19 71.2 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EFC35427.1 - 0.001 19.3 0.1 0.0013 19.0 0.1 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport ANAPC4_WD40 PF12894.7 EFC35428.1 - 0.0035 17.6 0.1 0.39 11.0 0.0 2.7 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain NHL PF01436.21 EFC35428.1 - 0.59 10.3 2.1 1.1 9.4 0.1 2.6 3 0 0 3 3 3 0 NHL repeat DUF4116 PF13475.6 EFC35429.1 - 5.7e-43 144.4 17.6 1.4e-15 56.7 0.0 7.1 5 2 3 8 8 8 7 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC35430.1 - 2e-22 79.8 0.2 4e-22 78.8 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35430.1 - 8.5e-22 77.7 0.0 7.1e-18 64.8 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Cytochrom_C_2 PF01322.20 EFC35431.1 - 0.084 13.8 0.1 0.16 12.9 0.1 1.4 1 0 0 1 1 1 0 Cytochrome C' APG6_N PF17675.1 EFC35431.1 - 0.24 11.9 12.9 0.46 11.0 12.9 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 EFC35431.1 - 0.5 10.4 2.9 0.73 9.9 2.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) VWA PF00092.28 EFC35432.1 - 1.8e-08 34.8 0.1 3.6e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC35432.1 - 4.8e-07 30.4 0.0 1e-06 29.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC35432.1 - 0.0048 16.9 0.1 0.01 15.8 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain PaRep2b PF07775.11 EFC35432.1 - 0.12 10.8 0.0 0.21 10.1 0.0 1.3 1 0 0 1 1 1 0 PaRep2b protein AMP-binding PF00501.28 EFC35433.1 - 0.0023 16.6 0.0 0.0037 15.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Pkinase PF00069.25 EFC35434.1 - 4.5e-56 190.1 0.0 7.7e-56 189.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35434.1 - 1.5e-52 178.5 0.1 4.1e-45 154.1 0.0 2.2 1 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFC35434.1 - 0.00022 21.2 0.0 0.00033 20.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC35434.1 - 0.00042 19.4 0.0 0.0022 17.0 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain DUF2258 PF10015.9 EFC35434.1 - 0.035 14.2 0.1 0.11 12.6 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) Fructosamin_kin PF03881.14 EFC35434.1 - 0.069 12.3 0.0 0.27 10.4 0.0 1.8 1 1 1 2 2 2 0 Fructosamine kinase DUF4436 PF14494.6 EFC35434.1 - 0.086 12.1 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) LRR_6 PF13516.6 EFC35435.1 - 3.2e-93 298.0 34.0 6e-07 29.0 0.1 19.2 19 0 0 19 19 19 18 Leucine Rich repeat LRR_8 PF13855.6 EFC35435.1 - 6.2e-56 186.0 16.8 1.2e-08 34.6 0.2 7.9 4 2 1 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC35435.1 - 2.1e-51 171.0 29.7 0.0001 22.6 0.2 11.6 2 2 7 13 13 13 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35435.1 - 2.8e-31 103.2 0.3 2.7 8.9 0.0 18.0 20 0 0 20 20 20 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC35435.1 - 3.3e-10 39.7 4.1 0.045 13.3 0.0 5.7 1 1 5 6 6 6 5 Leucine-rich repeat DUF4347 PF14252.6 EFC35435.1 - 5.8e-06 26.2 4.5 10 6.0 0.0 8.6 4 3 3 8 8 8 1 Domain of unknown function (DUF4347) Beta_helix PF13229.6 EFC35435.1 - 0.011 15.6 5.7 0.011 15.6 5.7 4.9 2 1 3 5 5 5 0 Right handed beta helix region DUF5612 PF18462.1 EFC35435.1 - 4 7.2 9.7 44 3.8 0.2 4.7 2 2 1 5 5 5 0 Domain of unknown function (DUF5612) DOMON PF03351.17 EFC35437.1 - 5e-29 101.0 7.1 1.2e-09 38.5 0.1 3.5 3 0 0 3 3 3 3 DOMON domain WG_beta_rep PF14903.6 EFC35437.1 - 0.021 15.1 1.6 4.6 7.6 0.1 3.1 3 0 0 3 3 3 0 WG containing repeat Kelch_6 PF13964.6 EFC35439.1 - 0.018 15.3 12.0 0.55 10.6 0.0 4.8 4 2 1 5 5 5 0 Kelch motif PQQ_3 PF13570.6 EFC35439.1 - 0.079 13.5 2.7 27 5.4 0.0 3.7 3 0 0 3 3 3 0 PQQ-like domain VWA_2 PF13519.6 EFC35440.1 - 5.5e-06 27.0 0.0 1.4e-05 25.6 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC35440.1 - 0.00051 20.3 0.1 0.0022 18.3 0.1 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC35440.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein RepA_N PF06970.11 EFC35440.1 - 0.13 12.2 0.0 5.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Replication initiator protein A (RepA) N-terminus ADK_lid PF05191.14 EFC35442.1 - 0.2 11.7 3.4 0.63 10.1 0.1 2.6 2 0 0 2 2 2 0 Adenylate kinase, active site lid Thioredoxin_9 PF14595.6 EFC35443.1 - 0.12 12.1 0.1 0.12 12.1 0.1 2.6 3 0 0 3 3 3 0 Thioredoxin HTH_52 PF18576.1 EFC35443.1 - 0.18 12.0 2.3 1.1 9.5 0.5 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain WD40 PF00400.32 EFC35444.1 - 6.8e-17 61.5 8.1 0.0003 21.5 0.3 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 EFC35444.1 - 0.024 13.3 0.3 0.2 10.3 0.1 2.3 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DNA_pol_phi PF04931.13 EFC35444.1 - 5.6 4.9 12.9 6.6 4.7 12.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFC35444.1 - 7.9 5.7 8.9 14 4.9 8.9 1.5 1 0 0 1 1 1 0 NOA36 protein RWP-RK PF02042.15 EFC35445.1 - 1.3e-05 25.1 0.2 2.6e-05 24.1 0.2 1.5 1 0 0 1 1 1 1 RWP-RK domain DUF1279 PF06916.13 EFC35446.1 - 3.7e-16 59.4 0.7 1e-15 58.0 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1279) PolyA_pol PF01743.20 EFC35449.1 - 8.4e-10 39.2 0.0 2.5e-09 37.6 0.0 1.8 2 1 0 2 2 2 1 Poly A polymerase head domain Lipase_3 PF01764.25 EFC35450.1 - 6.5e-17 61.7 0.0 2.3e-16 59.9 0.0 2.0 1 0 0 1 1 1 1 Lipase (class 3) MMR_HSR1 PF01926.23 EFC35450.1 - 9.5e-07 28.9 0.0 3.1e-06 27.2 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFC35450.1 - 3.6e-06 27.2 0.1 9.5e-06 25.8 0.1 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC35450.1 - 0.00073 19.2 0.1 0.0021 17.7 0.1 1.7 1 0 0 1 1 1 1 Ras family Spore_IV_A PF09547.10 EFC35450.1 - 0.00083 18.4 0.9 0.0069 15.4 0.0 2.3 2 0 0 2 2 2 1 Stage IV sporulation protein A (spore_IV_A) GTP_EFTU PF00009.27 EFC35450.1 - 0.0013 18.3 1.5 0.019 14.5 1.4 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATPase PF06745.13 EFC35450.1 - 0.0017 17.8 0.0 0.0048 16.3 0.0 1.7 1 0 0 1 1 1 1 KaiC DUF5567 PF17722.1 EFC35450.1 - 0.0045 16.9 0.5 0.0085 16.0 0.5 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5567) DUF2207 PF09972.9 EFC35450.1 - 0.0049 15.7 0.4 0.0092 14.8 0.4 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Dynamin_N PF00350.23 EFC35450.1 - 0.005 16.9 0.2 0.025 14.7 0.1 2.2 1 1 1 2 2 2 1 Dynamin family AAA_14 PF13173.6 EFC35450.1 - 0.018 15.1 0.0 0.071 13.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain Hydrolase_4 PF12146.8 EFC35450.1 - 0.046 13.0 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC35450.1 - 0.052 14.1 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Pkinase PF00069.25 EFC35452.1 - 2.6e-43 148.3 0.4 4.9e-43 147.4 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35452.1 - 5.2e-40 137.4 0.1 2.1e-38 132.1 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC35452.1 - 1.5e-06 27.2 0.1 2.2e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC35452.1 - 0.0055 16.6 0.0 0.0097 15.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC35452.1 - 0.021 13.8 0.0 0.031 13.2 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EFC35452.1 - 0.051 12.9 0.0 0.064 12.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like VWA_3 PF13768.6 EFC35453.1 - 1.5e-13 51.0 0.0 2.9e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Peptidase_C25_C PF03785.14 EFC35453.1 - 0.025 14.4 0.3 0.059 13.2 0.3 1.6 1 0 0 1 1 1 0 Peptidase family C25, C terminal ig-like domain LAGLIDADG_3 PF14528.6 EFC35454.1 - 0.046 14.0 0.0 0.15 12.4 0.0 1.9 1 0 0 1 1 1 0 LAGLIDADG-like domain Cytomega_UL20A PF05984.12 EFC35454.1 - 1.8 8.9 8.7 0.17 12.2 1.5 2.6 2 1 0 2 2 2 0 Cytomegalovirus UL20A protein LRR_6 PF13516.6 EFC35455.1 - 1.6e-14 52.6 0.9 0.00056 19.7 0.0 3.8 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 EFC35455.1 - 3.4e-07 30.5 2.0 0.049 14.1 0.0 3.5 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC35455.1 - 0.00023 20.9 2.5 0.005 16.6 0.1 2.9 2 1 1 3 3 3 2 Leucine rich repeat F-box-like PF12937.7 EFC35455.1 - 0.0076 16.1 0.1 0.014 15.3 0.1 1.5 1 1 0 1 1 1 1 F-box-like ApoB100_C PF12491.8 EFC35455.1 - 0.059 13.4 1.6 13 5.9 0.0 3.7 2 2 1 3 3 3 0 Apolipoprotein B100 C terminal LRR_1 PF00560.33 EFC35455.1 - 0.27 11.9 0.9 31 5.7 0.0 3.5 3 2 0 3 3 3 0 Leucine Rich Repeat Peptidase_M24 PF00557.24 EFC35456.1 - 3.8e-32 111.7 0.2 4.1e-32 111.6 0.2 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 EGF_2 PF07974.13 EFC35457.1 - 1.9e-17 63.3 85.5 0.00013 22.2 7.8 6.4 6 0 0 6 6 6 6 EGF-like domain EGF PF00008.27 EFC35457.1 - 0.0047 17.2 1.8 0.0047 17.2 1.8 7.3 8 0 0 8 8 8 5 EGF-like domain I-EGF_1 PF18372.1 EFC35458.1 - 0.0014 18.7 2.6 0.0014 18.7 2.6 2.3 2 0 0 2 2 2 1 Integrin beta epidermal growth factor like domain 1 TMEM154 PF15102.6 EFC35458.1 - 0.026 14.4 0.8 0.07 13.0 0.8 1.7 1 0 0 1 1 1 0 TMEM154 protein family Yip1 PF04893.17 EFC35458.1 - 0.042 13.6 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Yip1 domain Rota_NS6 PF04866.12 EFC35458.1 - 0.076 13.2 0.2 0.27 11.5 0.2 1.9 1 0 0 1 1 1 0 Rotavirus non-structural protein 6 EGF_2 PF07974.13 EFC35458.1 - 1.7 9.1 11.4 0.32 11.4 6.8 2.1 2 0 0 2 2 2 0 EGF-like domain SUI1 PF01253.22 EFC35459.1 - 1.5e-15 57.4 0.1 3.2e-15 56.4 0.1 1.5 1 1 0 1 1 1 1 Translation initiation factor SUI1 PhoLip_ATPase_N PF16209.5 EFC35461.1 - 7.2e-21 73.7 2.0 1.6e-20 72.5 2.0 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal GHMP_kinases_C PF08544.13 EFC35462.1 - 1.2e-07 32.0 0.4 3.8e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 EFC35462.1 - 0.00067 19.8 0.0 0.0026 17.9 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain Occludin_ELL PF07303.13 EFC35463.1 - 0.017 15.9 5.9 0.017 15.9 5.9 2.7 2 0 0 2 2 2 0 Occludin homology domain Ral PF11058.8 EFC35463.1 - 0.13 11.8 2.4 11 5.7 0.3 2.7 2 0 0 2 2 2 0 Antirestriction protein Ral DUF4473 PF14747.6 EFC35463.1 - 1.8 9.1 5.7 16 6.1 0.1 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4473) AMP-binding PF00501.28 EFC35465.1 - 2.1e-34 118.8 0.0 2.5e-34 118.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme sCache_like PF16736.5 EFC35465.1 - 0.045 13.8 0.1 0.081 13.0 0.1 1.4 1 0 0 1 1 1 0 Single Cache-like Abhydrolase_1 PF00561.20 EFC35466.1 - 2.1e-09 37.4 0.1 2.9e-06 27.1 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC35466.1 - 4.5e-08 32.6 0.0 6.1e-06 25.7 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC35466.1 - 6.2e-08 32.4 0.0 3.7e-05 23.3 0.0 2.0 2 0 0 2 2 2 2 Prolyl oligopeptidase family FSH1 PF03959.13 EFC35466.1 - 0.00018 21.2 0.0 0.00019 21.1 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 EFC35466.1 - 0.00036 20.2 0.1 0.0018 17.8 0.1 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EFC35466.1 - 0.00041 20.2 0.1 0.018 14.9 0.0 2.0 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 EFC35466.1 - 0.0048 17.0 0.0 0.0085 16.2 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein BAAT_C PF08840.11 EFC35466.1 - 0.015 15.2 0.1 0.68 9.8 0.0 2.1 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase_phd PF10503.9 EFC35466.1 - 0.021 14.3 0.0 0.14 11.6 0.0 1.9 1 1 0 1 1 1 0 Esterase PHB depolymerase Abhydrolase_6 PF12697.7 EFC35466.1 - 0.081 13.5 0.0 7.8 7.0 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase family 3HBOH PF10605.9 EFC35466.1 - 0.095 10.9 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) Abhydrolase_3 PF07859.13 EFC35466.1 - 0.16 11.8 0.0 0.51 10.2 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Mito_carr PF00153.27 EFC35467.1 - 2.7e-08 33.6 0.2 8.3e-05 22.4 0.1 2.5 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF3938 PF13074.6 EFC35467.1 - 0.063 13.5 1.3 4.9 7.5 0.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3938) CDP-OH_P_tran_2 PF08009.11 EFC35467.1 - 0.11 12.4 0.7 0.22 11.4 0.1 1.9 2 0 0 2 2 2 0 CDP-alcohol phosphatidyltransferase 2 NiFe_hyd_3_EhaA PF17367.2 EFC35467.1 - 1.2 9.3 5.3 3.6 7.8 0.2 3.2 3 1 1 4 4 4 0 NiFe-hydrogenase-type-3 Eha complex subunit A DUF2703 PF10865.8 EFC35468.1 - 0.096 12.9 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) Cwf_Cwc_15 PF04889.12 EFC35468.1 - 0.73 9.5 14.2 0.064 13.0 9.4 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF4484 PF14831.6 EFC35468.1 - 1.7 8.7 6.1 1.1 9.2 4.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4484) NOA36 PF06524.12 EFC35468.1 - 3.7 6.8 8.9 6.2 6.0 8.9 1.3 1 0 0 1 1 1 0 NOA36 protein PDE8 PF08629.10 EFC35468.1 - 7.8 6.6 7.9 5.3 7.1 2.6 2.7 2 0 0 2 2 2 0 PDE8 phosphodiesterase EGF_2 PF07974.13 EFC35470.1 - 2.1e-65 216.7 322.4 0.00022 21.5 9.6 23.1 23 0 0 23 23 23 22 EGF-like domain B9-C2 PF07162.11 EFC35470.1 - 7.1e-07 29.6 8.1 1.5 9.0 0.0 6.6 8 1 1 9 9 9 4 Ciliary basal body-associated, B9 protein EGF PF00008.27 EFC35470.1 - 1.1e-06 28.8 251.9 0.0046 17.2 2.1 23.2 22 0 0 22 22 22 15 EGF-like domain MORN PF02493.20 EFC35470.1 - 0.0015 18.3 2.9 22 5.2 0.0 6.5 7 0 0 7 7 7 1 MORN repeat PYST-C1 PF09690.10 EFC35470.1 - 0.045 13.5 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) Phage_integrase PF00589.22 EFC35471.1 - 5.1e-05 23.1 0.0 5.5e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Phage integrase family Fib_alpha PF08702.10 EFC35472.1 - 0.011 15.9 0.1 0.011 15.9 0.1 2.5 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family HGD-D PF06050.13 EFC35472.1 - 0.021 14.6 0.1 0.047 13.4 0.1 1.4 1 1 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Ins_beta PF03488.14 EFC35472.1 - 0.18 11.8 2.5 0.49 10.5 1.3 2.3 2 0 0 2 2 2 0 Nematode insulin-related peptide beta type Cytochrom_NNT PF03264.14 EFC35473.1 - 0.019 14.7 8.4 0.3 10.8 3.2 2.1 2 0 0 2 2 2 0 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 EFC35473.1 - 0.13 12.3 9.9 2.4 8.2 2.1 3.0 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c zf-C2H2 PF00096.26 EFC35473.1 - 0.49 11.0 0.2 0.49 11.0 0.2 3.1 2 1 0 2 2 2 0 Zinc finger, C2H2 type HNH PF01844.23 EFC35473.1 - 0.64 10.2 17.4 1.7 8.9 0.3 4.5 5 0 0 5 5 5 0 HNH endonuclease Zn-ribbon_8 PF09723.10 EFC35473.1 - 1.9 8.7 5.5 14 5.9 0.2 3.2 3 0 0 3 3 3 0 Zinc ribbon domain NRDE-2 PF08424.10 EFC35474.1 - 3.9e-06 26.2 5.1 6.1e-06 25.6 1.6 2.6 2 1 1 3 3 3 2 NRDE-2, necessary for RNA interference Suf PF05843.14 EFC35474.1 - 0.00072 19.6 9.0 0.002 18.1 9.0 1.8 1 1 0 1 1 1 1 Suppressor of forked protein (Suf) TPR_1 PF00515.28 EFC35474.1 - 0.057 13.3 0.3 3.9 7.4 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC35474.1 - 0.087 13.7 0.0 59 4.9 0.0 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat Ku PF02735.16 EFC35475.1 - 8e-40 136.7 0.1 1.3e-39 136.0 0.1 1.3 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain DUF3926 PF13080.6 EFC35475.1 - 0.61 10.1 6.7 2.6 8.1 6.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3926) F-box PF00646.33 EFC35476.1 - 0.016 15.0 0.2 0.037 13.9 0.2 1.6 1 0 0 1 1 1 0 F-box domain Ras PF00071.22 EFC35476.1 - 0.027 14.1 0.0 0.063 12.9 0.0 1.6 2 0 0 2 2 2 0 Ras family AAA_18 PF13238.6 EFC35476.1 - 0.074 13.6 0.2 0.52 10.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFC35476.1 - 0.074 12.8 0.0 0.18 11.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain Herpes_TK PF00693.18 EFC35476.1 - 0.17 11.1 0.3 0.81 8.9 0.2 1.9 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus RCC1_2 PF13540.6 EFC35477.1 - 8.6e-11 41.3 6.4 1.6e-06 27.7 0.7 2.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC35477.1 - 5.5e-05 23.7 1.8 0.21 12.2 0.0 3.1 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat DUF4246 PF14033.6 EFC35478.1 - 1.7e-11 43.9 0.1 2.4e-11 43.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) Actin PF00022.19 EFC35479.1 - 1.9e-90 303.4 0.1 1e-89 301.0 0.1 1.8 1 1 0 1 1 1 1 Actin Cyt-b5 PF00173.28 EFC35480.1 - 2.6e-15 56.3 0.1 3.1e-15 56.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF563 PF04577.14 EFC35483.1 - 6.8e-31 108.0 0.1 7.8e-31 107.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF4116 PF13475.6 EFC35484.1 - 3.2e-25 87.6 4.2 1.7e-07 30.9 0.0 6.6 6 1 0 6 6 6 4 Domain of unknown function (DUF4116) Stm1_N PF09598.10 EFC35484.1 - 0.031 15.1 0.7 0.057 14.3 0.7 1.4 1 0 0 1 1 1 0 Stm1 RasGEF PF00617.19 EFC35485.1 - 1.1e-34 120.2 4.8 1.9e-34 119.4 4.8 1.4 1 0 0 1 1 1 1 RasGEF domain PAC4 PF16093.5 EFC35486.1 - 2.4 8.4 9.7 0.12 12.6 3.0 2.3 2 1 1 3 3 3 0 Proteasome assembly chaperone 4 FAD_binding_5 PF00941.21 EFC35487.1 - 1.5e-26 93.2 0.0 4.8e-26 91.5 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 EFC35487.1 - 1.4e-14 54.4 0.0 3.7e-14 53.0 0.0 1.8 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 EFC35487.1 - 1.7e-10 41.0 0.0 1.3e-09 38.1 0.0 2.2 1 1 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain PP-binding_2 PF14573.6 EFC35488.1 - 0.012 15.8 0.1 0.024 14.8 0.1 1.5 1 0 0 1 1 1 0 Acyl-carrier ERM PF00769.19 EFC35488.1 - 0.032 14.1 19.2 0.038 13.8 19.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family TRPM_tetra PF16519.5 EFC35488.1 - 0.053 13.6 3.1 0.053 13.6 3.1 3.3 1 1 1 3 3 3 0 Tetramerisation domain of TRPM Pterin_bind PF00809.22 EFC35488.1 - 0.06 13.0 4.6 0.28 10.8 0.6 2.1 1 1 1 2 2 2 0 Pterin binding enzyme DASH_Dad3 PF08656.10 EFC35488.1 - 2 8.6 8.8 0.6 10.2 3.0 2.5 1 1 1 2 2 2 0 DASH complex subunit Dad3 DUF4988 PF16378.5 EFC35488.1 - 2 8.0 7.8 1.7 8.3 1.4 2.3 2 0 0 2 2 2 0 Domain of unknown function Fib_alpha PF08702.10 EFC35488.1 - 2.8 8.1 27.4 8.6 6.5 1.1 3.0 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Sin3_corepress PF08295.12 EFC35488.1 - 6.3 6.9 13.0 0.74 9.9 4.2 2.7 2 1 1 3 3 3 0 Sin3 family co-repressor XhlA PF10779.9 EFC35488.1 - 6.5 7.0 15.7 8.3 6.7 0.2 3.5 3 0 0 3 3 3 0 Haemolysin XhlA RNase_T PF00929.24 EFC35489.1 - 7.7e-05 23.3 0.5 7.7e-05 23.3 0.5 4.2 5 1 0 5 5 5 1 Exonuclease TcdB_toxin_midC PF12255.8 EFC35490.1 - 6.3 6.9 6.8 1.6 8.8 1.4 2.3 2 0 0 2 2 2 0 Insecticide toxin TcdB middle/C-terminal region Helicase_C PF00271.31 EFC35491.1 - 1.4e-07 31.8 0.0 2.7e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Peptidase_M18 PF02127.15 EFC35492.1 - 9e-76 255.4 0.0 1e-75 255.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) DUF2612 PF11041.8 EFC35492.1 - 0.12 12.2 0.2 0.86 9.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2612) FAM209 PF15206.6 EFC35493.1 - 0.092 12.5 0.6 0.12 12.2 0.6 1.3 1 1 0 1 1 1 0 FAM209 family CemA PF03040.14 EFC35494.1 - 0.0077 16.2 1.1 0.01 15.8 1.1 1.1 1 0 0 1 1 1 1 CemA family Mei5 PF10376.9 EFC35494.1 - 0.017 15.0 1.2 0.022 14.6 1.2 1.2 1 0 0 1 1 1 0 Double-strand recombination repair protein UPF0242 PF06785.11 EFC35494.1 - 0.019 15.1 0.8 0.026 14.6 0.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Frigida PF07899.11 EFC35494.1 - 0.022 14.0 1.9 0.03 13.6 1.9 1.1 1 0 0 1 1 1 0 Frigida-like protein EGF_2 PF07974.13 EFC35495.1 - 0.23 11.9 7.9 0.49 10.8 7.9 1.5 1 0 0 1 1 1 0 EGF-like domain Transposase_21 PF02992.14 EFC35496.1 - 6.1e-09 35.4 0.6 1.1e-08 34.7 0.6 1.4 1 0 0 1 1 1 1 Transposase family tnp2 DUF1258 PF06869.12 EFC35496.1 - 0.0002 20.9 0.1 0.00035 20.2 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1258) DDE_Tnp_ISAZ013 PF07592.11 EFC35497.1 - 0.08 11.9 0.0 0.12 11.3 0.0 1.4 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain BING4CT PF08149.11 EFC35497.1 - 0.19 11.6 1.8 9.3 6.1 0.0 2.9 3 1 0 3 3 3 0 BING4CT (NUC141) domain OmpH PF03938.14 EFC35499.1 - 0.072 13.4 1.1 0.15 12.4 0.1 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) NHL PF01436.21 EFC35500.1 - 2.5e-20 71.4 7.9 0.00025 20.9 0.1 8.9 10 0 0 10 10 10 5 NHL repeat SGL PF08450.12 EFC35500.1 - 1.5e-05 24.8 5.4 0.016 14.8 0.3 4.8 2 1 3 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EFC35500.1 - 0.00014 21.8 0.5 1.1 9.3 0.1 3.6 2 0 0 2 2 2 2 Beta-propeller repeat Reg_prop PF07494.11 EFC35500.1 - 0.00021 21.1 0.3 5.9 7.5 0.0 6.2 6 1 1 7 7 7 1 Two component regulator propeller EGF_2 PF07974.13 EFC35500.1 - 0.00093 19.5 28.2 0.004 17.5 10.9 5.8 6 0 0 6 6 6 2 EGF-like domain DUF2427 PF10348.9 EFC35500.1 - 0.033 14.0 0.0 0.088 12.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) Hamartin PF04388.12 EFC35501.1 - 0.12 11.1 15.3 0.15 10.7 15.3 1.2 1 0 0 1 1 1 0 Hamartin protein BSD PF03909.17 EFC35502.1 - 5.2e-05 23.2 0.1 0.00015 21.7 0.1 1.9 1 0 0 1 1 1 1 BSD domain SR-25 PF10500.9 EFC35502.1 - 0.00079 19.1 13.4 0.0011 18.6 13.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Menin PF05053.13 EFC35502.1 - 0.038 12.4 10.8 0.048 12.0 10.8 1.3 1 0 0 1 1 1 0 Menin Suf PF05843.14 EFC35502.1 - 0.51 10.3 14.3 0.75 9.7 14.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Ndc1_Nup PF09531.10 EFC35502.1 - 0.74 8.4 13.0 1.1 7.9 13.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFC35502.1 - 0.92 8.2 15.9 1.2 7.8 15.9 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 EFC35502.1 - 1.5 7.8 20.0 2 7.4 20.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 SDA1 PF05285.12 EFC35502.1 - 1.7 8.0 19.1 2.1 7.7 19.1 1.1 1 0 0 1 1 1 0 SDA1 Mucin PF01456.17 EFC35502.1 - 1.9 8.5 14.4 2.7 8.0 14.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 EFC35502.1 - 9.6 6.7 15.5 17 5.9 15.5 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin TLD PF07534.16 EFC35503.1 - 5.6e-17 62.3 4.2 7.8e-16 58.5 4.2 2.0 1 1 0 1 1 1 1 TLD Orf78 PF06024.12 EFC35504.1 - 6.5 7.1 6.3 1.4 9.3 0.6 2.5 3 0 0 3 3 3 0 Orf78 (ac78) RPN2_C PF18004.1 EFC35505.1 - 3.9e-24 85.4 2.2 3.9e-24 85.4 2.2 2.3 2 1 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain Lipase_3 PF01764.25 EFC35506.1 - 3.1e-17 62.8 0.0 1e-16 61.1 0.0 1.9 1 0 0 1 1 1 1 Lipase (class 3) MMR_HSR1 PF01926.23 EFC35506.1 - 5.8e-07 29.6 0.0 1.5e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFC35506.1 - 1.8e-06 28.1 0.1 4.5e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35506.1 - 7.6e-05 22.2 0.1 0.00015 21.3 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Spore_IV_A PF09547.10 EFC35506.1 - 0.00029 19.9 1.1 0.0038 16.2 0.0 2.3 2 0 0 2 2 2 1 Stage IV sporulation protein A (spore_IV_A) Ras PF00071.22 EFC35506.1 - 0.00037 20.1 0.1 0.00094 18.8 0.1 1.6 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EFC35506.1 - 0.0006 19.4 2.4 0.011 15.3 1.4 2.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain ATPase PF06745.13 EFC35506.1 - 0.00072 19.0 0.0 0.0023 17.3 0.0 1.9 1 0 0 1 1 1 1 KaiC DUF5567 PF17722.1 EFC35506.1 - 0.0027 17.6 0.5 0.0049 16.8 0.5 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5567) AAA_14 PF13173.6 EFC35506.1 - 0.0087 16.1 0.0 0.035 14.1 0.0 2.2 1 0 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 EFC35506.1 - 0.013 15.6 0.1 0.013 15.6 0.1 2.2 2 1 1 3 3 3 0 Dynamin family Hydrolase_4 PF12146.8 EFC35506.1 - 0.032 13.5 0.1 0.17 11.1 0.0 2.1 3 0 0 3 3 3 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC35506.1 - 0.036 14.7 0.0 0.058 14.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family FeoB_N PF02421.18 EFC35506.1 - 0.094 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B RNase_H PF00075.24 EFC35507.1 - 1.3e-11 44.9 0.9 2.1e-11 44.2 0.1 1.8 2 0 0 2 2 2 1 RNase H CS PF04969.16 EFC35508.1 - 0.00099 20.1 0.2 0.0025 18.8 0.2 1.8 1 0 0 1 1 1 1 CS domain Nop14 PF04147.12 EFC35509.1 - 9.6 4.3 11.3 11 4.0 11.3 1.0 1 0 0 1 1 1 0 Nop14-like family LRR_6 PF13516.6 EFC35510.1 - 4.1e-37 123.1 8.3 1.1e-05 25.1 0.1 6.2 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC35510.1 - 2.4e-18 65.6 5.6 8.3e-09 35.1 1.8 2.4 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFC35510.1 - 3.9e-16 58.9 14.6 5.7e-05 23.4 1.7 3.5 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35510.1 - 1.7e-11 43.0 3.1 4.6 8.2 0.1 6.0 6 0 0 6 6 6 5 Leucine Rich Repeat LRR_9 PF14580.6 EFC35510.1 - 0.0013 18.3 3.9 0.0023 17.5 0.4 2.1 1 1 1 2 2 2 1 Leucine-rich repeat DUF1825 PF08855.10 EFC35510.1 - 0.033 14.1 0.3 0.82 9.6 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1825) DUF2100 PF09873.9 EFC35510.1 - 0.045 13.6 5.9 6.9 6.5 0.1 3.6 1 1 4 5 5 5 0 Uncharacterized protein conserved in archaea (DUF2100) Lsm_C PF14894.6 EFC35510.1 - 0.056 13.2 4.0 1.5 8.7 0.3 3.3 1 1 2 3 3 3 0 Lsm C-terminal LRR_6 PF13516.6 EFC35511.1 - 8.2e-78 250.0 19.5 3.6e-06 26.6 0.0 12.0 12 0 0 12 12 12 12 Leucine Rich repeat LRR_8 PF13855.6 EFC35511.1 - 1.4e-33 114.4 15.3 1.9e-08 34.0 0.8 4.5 4 1 0 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFC35511.1 - 1.4e-26 88.9 2.0 3.1 8.7 0.0 11.7 12 0 0 12 12 12 5 Leucine Rich Repeat LRR_4 PF12799.7 EFC35511.1 - 1.5e-25 88.8 34.2 0.00013 22.3 1.3 7.2 2 1 6 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC35511.1 - 2.9e-06 26.9 8.2 0.0065 16.0 0.3 3.8 1 1 3 4 4 4 3 Leucine-rich repeat PapC_C PF13953.6 EFC35511.1 - 4.8e-05 23.1 0.7 13 5.7 0.0 5.7 3 3 4 7 7 7 1 PapC C-terminal domain Lsm_C PF14894.6 EFC35511.1 - 0.035 13.9 4.0 4.3 7.2 0.2 4.7 3 1 3 6 6 6 0 Lsm C-terminal DUF4869 PF16163.5 EFC35511.1 - 0.21 11.3 9.0 4.8 6.9 0.1 4.4 1 1 4 5 5 5 0 Domain of unknown function (DUF4869) DUF3409 PF11889.8 EFC35511.1 - 0.24 11.3 0.5 77 3.3 0.0 4.7 6 0 0 6 6 6 0 Domain of unknown function (DUF3409) AlphaC_N PF08829.10 EFC35511.1 - 0.27 11.3 3.1 69 3.5 0.1 4.1 2 1 3 5 5 5 0 Alpha C protein N terminal PI_PP_I PF18363.1 EFC35511.1 - 0.46 10.7 11.1 27 5.0 0.1 4.6 3 2 2 5 5 5 0 Phosphoinositide phosphatase insertion domain DUF3784 PF12650.7 EFC35512.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) EGF_2 PF07974.13 EFC35513.1 - 5.3e-17 61.9 60.2 2.8e-06 27.6 8.4 4.6 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 EFC35513.1 - 6e-05 23.3 48.1 0.0059 16.9 2.4 5.3 5 0 0 5 5 5 3 EGF-like domain hEGF PF12661.7 EFC35513.1 - 0.014 16.0 2.5 0.014 16.0 2.5 6.4 7 1 1 8 8 8 0 Human growth factor-like EGF Laminin_EGF PF00053.24 EFC35513.1 - 0.032 14.4 54.7 0.66 10.2 8.4 4.4 1 1 3 4 4 4 0 Laminin EGF domain F-box-like PF12937.7 EFC35514.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 F-box-like Peripla_BP_1 PF00532.21 EFC35515.1 - 0.0063 16.0 0.0 0.0077 15.7 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding proteins and sugar binding domain of LacI family Ank PF00023.30 EFC35515.1 - 0.029 14.8 0.1 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 EFC35515.1 - 0.081 13.5 0.0 1.2 9.8 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) TnpB_IS66 PF05717.13 EFC35515.1 - 0.1 12.5 0.1 2.9 7.9 0.0 2.2 2 0 0 2 2 2 0 IS66 Orf2 like protein FAM176 PF14851.6 EFC35515.1 - 0.77 9.4 6.4 0.87 9.2 6.4 1.1 1 0 0 1 1 1 0 FAM176 family SGT1 PF07093.11 EFC35515.1 - 1.2 7.5 8.5 1.3 7.3 8.5 1.1 1 0 0 1 1 1 0 SGT1 protein ABC2_membrane_3 PF12698.7 EFC35517.1 - 1.4e-10 40.9 11.9 1.4e-06 27.7 5.7 2.3 1 1 1 2 2 2 2 ABC-2 family transporter protein ABC_tran PF00005.27 EFC35517.1 - 1.7e-05 25.3 0.4 1.7e-05 25.3 0.4 1.8 2 0 0 2 2 2 1 ABC transporter Microtub_bd PF16796.5 EFC35517.1 - 0.00044 20.2 0.0 0.0032 17.4 0.0 2.2 1 1 1 2 2 2 1 Microtubule binding ABC2_membrane_2 PF12679.7 EFC35517.1 - 0.0044 16.3 6.5 0.016 14.5 6.9 1.7 1 1 1 2 2 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFC35517.1 - 0.12 12.2 0.5 0.22 11.4 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 EFC35517.1 - 0.14 11.6 0.7 2.5 7.6 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region Kinesin PF00225.23 EFC35518.1 - 1.6e-107 359.3 0.9 1.6e-107 359.3 0.9 2.5 3 1 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EFC35518.1 - 5.6e-21 75.0 1.4 5.6e-21 75.0 1.4 3.7 1 1 1 2 2 2 1 Microtubule binding zf-C3HC4_3 PF13920.6 EFC35519.1 - 2.2e-09 37.0 19.9 3.4e-09 36.4 19.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC35519.1 - 2.1e-05 24.3 20.6 3.8e-05 23.4 20.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFC35519.1 - 0.00023 20.9 22.0 0.00046 20.0 22.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_ODV-E27 PF05314.11 EFC35519.1 - 0.0055 15.9 4.4 0.0078 15.4 4.4 1.3 1 0 0 1 1 1 1 Baculovirus occlusion-derived virus envelope protein EC27 zf-RING_6 PF14835.6 EFC35519.1 - 0.0073 16.2 11.1 0.015 15.2 11.1 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Ribosomal_L37 PF08561.10 EFC35519.1 - 0.011 16.3 0.4 0.011 16.3 0.4 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 zf-RING_5 PF14634.6 EFC35519.1 - 0.013 15.5 24.2 0.086 12.8 24.5 2.1 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 EFC35519.1 - 0.025 14.9 22.4 0.043 14.2 22.4 1.4 1 0 0 1 1 1 0 Ring finger domain ETRAMP PF09716.10 EFC35519.1 - 0.042 13.9 3.7 0.13 12.3 0.0 3.1 1 1 1 2 2 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4558 PF15104.6 EFC35519.1 - 0.06 13.4 22.5 0.46 10.6 4.9 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4558) zf-C3HC4 PF00097.25 EFC35519.1 - 0.071 13.0 24.0 0.15 12.0 24.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3078 PF11276.8 EFC35519.1 - 0.076 13.5 0.4 0.076 13.5 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3078) DUF808 PF05661.12 EFC35519.1 - 0.12 11.4 2.2 0.11 11.5 0.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF808) 7TM_GPCR_Srd PF10317.9 EFC35519.1 - 0.16 11.2 6.7 0.7 9.0 1.6 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srd zf-RING_UBOX PF13445.6 EFC35519.1 - 0.29 11.2 21.1 0.062 13.3 14.0 2.5 2 0 0 2 2 2 0 RING-type zinc-finger CCB1 PF12046.8 EFC35519.1 - 1.3 8.3 10.5 0.52 9.7 1.3 3.2 2 1 0 2 2 2 0 Cofactor assembly of complex C subunit B HIP1_clath_bdg PF16515.5 EFC35519.1 - 7.8 7.2 33.2 0.056 14.1 9.3 3.4 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HMMR_N PF15905.5 EFC35519.1 - 8.1 5.8 31.0 2.3 7.6 22.2 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal ABC2_membrane_3 PF12698.7 EFC35519.1 - 8.2 5.4 15.2 0.022 13.9 1.6 2.3 1 1 1 2 2 2 0 ABC-2 family transporter protein ASC PF00858.24 EFC35520.1 - 1.5e-08 34.1 1.3 4.4e-06 25.9 0.6 2.0 1 1 1 2 2 2 2 Amiloride-sensitive sodium channel Pkinase PF00069.25 EFC35521.1 - 4.6e-08 32.8 2.0 1.1e-07 31.5 2.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35521.1 - 4.2e-05 23.0 0.7 6.9e-05 22.3 0.7 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LapA_dom PF06305.11 EFC35522.1 - 0.048 13.5 1.6 0.11 12.3 1.6 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2684 PF10885.8 EFC35522.1 - 1.8 8.7 5.4 1.7 8.8 0.2 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2684) dCache_1 PF02743.18 EFC35523.1 - 0.00052 19.9 0.2 0.00085 19.2 0.2 1.5 1 1 0 1 1 1 1 Cache domain DUF996 PF06195.13 EFC35523.1 - 0.034 14.4 0.0 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF996) VWA PF00092.28 EFC35523.1 - 0.045 14.0 0.1 0.07 13.4 0.1 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain DctM PF06808.12 EFC35523.1 - 0.046 12.5 0.0 0.06 12.2 0.0 1.1 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporter, DctM component Coatomer_WDAD PF04053.14 EFC35525.1 - 4.9e-117 391.7 3.0 6.3e-117 391.3 3.0 1.1 1 0 0 1 1 1 1 Coatomer WD associated region Bacteroid_pep PF14406.6 EFC35525.1 - 0.038 14.4 1.3 3.4 8.1 0.0 3.1 3 0 0 3 3 3 0 Ribosomally synthesized peptide in Bacteroidetes ACP_PD PF04336.12 EFC35525.1 - 0.11 12.9 1.5 0.45 11.0 0.3 2.4 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase TPR_2 PF07719.17 EFC35525.1 - 0.12 12.5 2.9 2.3 8.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC35525.1 - 0.23 11.7 3.0 2.2 8.6 0.1 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EFC35525.1 - 0.29 11.0 3.5 1.8 8.5 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Gastrin PF00918.17 EFC35526.1 - 4.9 8.1 6.7 0.64 11.0 0.3 2.4 2 1 0 2 2 2 0 Gastrin/cholecystokinin family Nop25 PF09805.9 EFC35527.1 - 0.0021 18.6 20.1 0.0021 18.6 20.1 4.0 1 1 2 3 3 3 1 Nucleolar protein 12 (25kDa) Methyltransf_11 PF08241.12 EFC35528.1 - 2.4e-11 44.2 0.0 5e-11 43.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC35528.1 - 5.5e-10 39.2 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC35528.1 - 8e-10 39.3 0.0 3.1e-09 37.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC35528.1 - 0.00015 22.5 3.9 0.0011 19.7 0.0 2.8 3 1 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC35528.1 - 0.00044 19.6 0.1 0.001 18.5 0.1 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFC35528.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Pkinase PF00069.25 EFC35529.1 - 4.8e-50 170.4 0.2 7.8e-50 169.7 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35529.1 - 3.6e-46 157.5 0.2 1.1e-41 142.9 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase EGF_2 PF07974.13 EFC35529.1 - 1.7e-06 28.3 52.4 0.0087 16.4 7.8 3.9 4 0 0 4 4 4 3 EGF-like domain Pkinase_fungal PF17667.1 EFC35529.1 - 0.001 18.0 0.1 0.0015 17.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC35529.1 - 0.0016 17.5 0.7 0.004 16.2 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFC35529.1 - 0.0042 17.0 0.0 0.0065 16.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC35529.1 - 0.005 16.2 0.0 0.0083 15.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EFC35529.1 - 0.01 14.9 0.1 0.021 13.9 0.1 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 Kinase-like PF14531.6 EFC35529.1 - 0.015 14.6 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like EGF PF00008.27 EFC35529.1 - 0.047 14.0 27.2 1.2 9.5 6.3 4.0 3 0 0 3 3 3 0 EGF-like domain RIO1 PF01163.22 EFC35529.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family DUF4116 PF13475.6 EFC35530.1 - 4e-43 144.9 4.3 1.3e-16 60.1 0.2 4.1 3 1 1 4 4 4 4 Domain of unknown function (DUF4116) CbiG_C PF01890.16 EFC35530.1 - 0.0058 17.2 0.3 0.023 15.2 0.0 2.0 1 1 1 2 2 2 1 Cobalamin synthesis G C-terminus AAA_9 PF12781.7 EFC35532.1 - 0.0059 15.7 1.2 0.0097 15.1 1.2 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region DMPK_coil PF08826.10 EFC35533.1 - 0.77 9.9 6.2 1.7 8.8 2.4 2.2 1 1 1 2 2 2 0 DMPK coiled coil domain like P5CR_dimer PF14748.6 EFC35535.1 - 4.5e-16 59.0 0.0 7.9e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 EFC35535.1 - 8.7e-11 42.3 0.4 1.4e-10 41.6 0.4 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFC35535.1 - 0.00017 21.8 0.1 0.00056 20.1 0.0 1.9 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase PDH PF02153.17 EFC35535.1 - 0.0038 16.3 0.0 0.011 14.7 0.1 1.7 2 0 0 2 2 2 1 Prephenate dehydrogenase NAD_Gly3P_dh_N PF01210.23 EFC35535.1 - 0.038 14.0 1.0 0.061 13.3 1.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Mito_carr PF00153.27 EFC35536.1 - 6.8e-64 211.8 5.2 1.2e-21 76.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_hydro_99 PF16317.5 EFC35537.1 - 0.14 11.3 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 99 Ras PF00071.22 EFC35538.1 - 7e-47 159.0 7.0 2.4e-45 154.0 7.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC35538.1 - 4e-21 75.5 3.3 1.8e-19 70.1 1.0 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35538.1 - 2.7e-11 43.2 4.1 1.3e-09 37.7 4.1 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC35538.1 - 4.5e-06 26.7 0.3 6.7e-06 26.2 0.3 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC35538.1 - 0.0012 18.4 1.7 0.17 11.4 1.7 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC35538.1 - 0.0013 18.7 2.5 0.78 9.6 0.8 2.3 1 1 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EFC35538.1 - 0.0039 16.7 0.1 0.0077 15.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region SRPRB PF09439.10 EFC35538.1 - 0.0045 16.4 1.0 0.022 14.2 0.1 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit TniB PF05621.11 EFC35538.1 - 0.005 16.3 0.0 0.014 14.8 0.0 1.7 1 1 1 2 2 2 1 Bacterial TniB protein Septin PF00735.18 EFC35538.1 - 0.013 14.8 0.2 0.013 14.8 0.2 1.7 2 0 0 2 2 2 0 Septin Gtr1_RagA PF04670.12 EFC35538.1 - 0.017 14.5 3.5 0.18 11.1 0.2 2.1 1 1 0 2 2 2 0 Gtr1/RagA G protein conserved region PRP8_domainIV PF12134.8 EFC35538.1 - 0.025 14.2 0.1 0.031 13.9 0.1 1.2 1 0 0 1 1 1 0 PRP8 domain IV core AAA_16 PF13191.6 EFC35538.1 - 0.078 13.4 0.0 0.12 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ApoL PF05461.11 EFC35539.1 - 7.4e-08 32.1 3.7 1.3e-07 31.3 3.7 1.5 1 1 0 1 1 1 1 Apolipoprotein L DUF677 PF05055.12 EFC35539.1 - 0.0047 15.9 0.1 0.0064 15.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF677) DUF1993 PF09351.10 EFC35539.1 - 0.051 13.7 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) GPS PF01825.21 EFC35540.1 - 2.5e-06 27.9 0.4 5.7e-06 26.8 0.4 1.6 1 1 0 1 1 1 1 GPCR proteolysis site, GPS, motif DAG1 PF05454.11 EFC35540.1 - 8.6e-05 22.0 2.7 8.6e-05 22.0 2.7 1.5 1 1 1 2 2 2 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Shisa PF13908.6 EFC35540.1 - 0.011 16.0 0.5 0.011 16.0 0.5 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator CD20 PF04103.15 EFC35540.1 - 0.026 14.6 1.9 0.091 12.8 0.0 2.2 1 1 1 2 2 2 0 CD20-like family Syndecan PF01034.20 EFC35540.1 - 0.04 13.8 1.2 0.04 13.8 1.2 2.1 2 0 0 2 2 2 0 Syndecan domain OAD_gamma PF04277.13 EFC35540.1 - 0.14 12.8 0.3 0.14 12.8 0.3 2.7 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain B_lectin PF01453.24 EFC35540.1 - 1.7 9.2 6.3 3.1 8.4 0.7 2.2 1 1 1 2 2 2 0 D-mannose binding lectin Sel1 PF08238.12 EFC35541.1 - 8e-61 201.1 39.3 4e-09 36.8 0.3 11.3 10 1 0 10 10 10 10 Sel1 repeat DUF4116 PF13475.6 EFC35541.1 - 3.5e-25 87.5 6.0 4.7e-08 32.6 0.0 4.7 3 1 1 4 4 4 4 Domain of unknown function (DUF4116) TPR_6 PF13174.6 EFC35541.1 - 1.2e-08 35.0 18.5 1.1 10.0 0.2 8.7 8 2 1 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC35541.1 - 1.3e-07 31.2 24.6 0.0021 18.0 0.1 9.7 9 1 0 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC35541.1 - 2.3e-07 31.3 4.7 1.1 9.9 0.0 6.8 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC35541.1 - 3.7e-06 26.5 32.5 0.0011 18.7 0.6 9.8 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC35541.1 - 0.00064 19.7 0.7 0.00064 19.7 0.7 8.5 9 1 0 9 9 9 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC35541.1 - 0.0014 18.9 15.1 0.027 14.7 0.2 6.7 5 3 4 9 9 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC35541.1 - 0.0038 17.1 2.2 1.7 8.9 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC35541.1 - 0.012 15.9 16.8 8.7 7.0 0.0 8.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC35541.1 - 0.024 14.5 1.0 0.47 10.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC35541.1 - 0.027 14.7 23.6 0.19 12.0 1.7 5.8 3 1 2 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TAP_C PF03943.13 EFC35541.1 - 6.8 6.4 6.1 1.1e+02 2.6 0.1 4.7 5 0 0 5 5 5 0 TAP C-terminal domain LRR_6 PF13516.6 EFC35542.1 - 3.6e-77 248.0 13.9 3.9e-05 23.3 0.0 15.0 15 0 0 15 15 15 14 Leucine Rich repeat LRR_4 PF12799.7 EFC35542.1 - 2.1e-49 164.6 15.9 2.1e-06 28.0 0.1 8.8 3 2 5 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC35542.1 - 3.1e-44 148.5 11.2 1.3e-08 34.5 0.0 5.6 3 1 0 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 EFC35542.1 - 8e-29 95.7 0.4 7.7 7.5 0.0 14.8 15 0 0 15 15 15 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC35542.1 - 1.8e-10 40.6 9.7 0.044 13.3 0.9 5.0 1 1 7 8 8 8 8 Leucine-rich repeat Sialidase PF02973.16 EFC35542.1 - 2e-08 34.0 20.2 0.015 14.8 1.9 4.6 2 1 3 5 5 5 3 Sialidase, N-terminal domain ApoB100_C PF12491.8 EFC35542.1 - 2.8e-05 24.0 16.2 9.2 6.3 0.0 8.9 7 4 4 11 11 11 1 Apolipoprotein B100 C terminal bZIP_C PF12498.8 EFC35542.1 - 7.8e-05 23.7 3.3 25 5.9 0.0 4.9 1 1 5 6 6 6 0 Basic leucine-zipper C terminal NKWYS PF10364.9 EFC35542.1 - 8.7e-05 22.7 12.6 1.3 9.1 0.1 6.3 1 1 4 7 7 7 1 Putative capsular polysaccharide synthesis protein DUF424 PF04242.13 EFC35542.1 - 0.00021 21.5 14.2 1 9.7 0.2 5.8 3 3 1 5 5 5 2 Protein of unknown function (DUF424) Beta_helix PF13229.6 EFC35542.1 - 0.00087 19.2 23.0 0.14 12.0 6.7 3.5 1 1 2 3 3 3 3 Right handed beta helix region Tropomyosin PF00261.20 EFC35542.1 - 1.4 8.3 9.1 14 5.0 0.1 3.9 4 1 1 5 5 5 0 Tropomyosin UPF0193 PF05250.11 EFC35542.1 - 2.3 8.0 20.6 6.1 6.6 0.2 5.2 3 1 2 5 5 5 0 Uncharacterised protein family (UPF0193) adh_short PF00106.25 EFC35543.1 - 1.7e-30 105.9 0.2 2e-26 92.7 0.3 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC35543.1 - 4.9e-19 68.8 0.0 2.2e-18 66.7 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC35543.1 - 6.6e-05 22.9 0.1 9.1e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Flavodoxin_4 PF12682.7 EFC35543.1 - 0.0018 18.0 0.0 0.0032 17.2 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin Glyco_transf_34 PF05637.12 EFC35544.1 - 4.8e-16 59.2 8.1 2e-14 53.9 8.1 2.2 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 EFC35544.1 - 0.00041 20.0 0.4 0.00055 19.6 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF273 DUF3146 PF11344.8 EFC35544.1 - 0.057 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) Phage_integrase PF00589.22 EFC35549.1 - 7.2e-06 25.9 0.0 2.3e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Phage integrase family DUF2666 PF10869.8 EFC35549.1 - 0.055 13.7 1.9 0.33 11.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2666) DUF924 PF06041.11 EFC35550.1 - 1.3e-54 185.1 2.5 1.5e-54 184.9 2.5 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) PhoPQ_related PF10142.9 EFC35551.1 - 1.9e-57 194.6 0.6 2.2e-57 194.4 0.6 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Peptidase_M16 PF00675.20 EFC35552.1 - 1.7e-09 37.8 0.0 1e-07 32.0 0.0 2.3 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) Glyco_hydro_71 PF03659.14 EFC35553.1 - 3.8e-19 68.7 1.3 5.2e-19 68.3 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 CHAT PF12770.7 EFC35554.1 - 1.7e-22 80.2 0.0 3e-21 76.1 0.0 2.1 1 1 0 1 1 1 1 CHAT domain Med22 PF06179.12 EFC35556.1 - 0.099 12.9 0.0 13 6.0 0.0 2.5 2 0 0 2 2 2 0 Surfeit locus protein 5 subunit 22 of Mediator complex IPK PF03770.16 EFC35557.1 - 8.4e-18 64.9 0.0 1.6e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase DUF898 PF05987.13 EFC35558.1 - 0.013 14.6 1.0 0.099 11.7 0.1 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) DUF728 PF05304.12 EFC35558.1 - 0.16 11.8 2.5 0.27 11.1 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF728) Herpes_UL49_2 PF04823.12 EFC35559.1 - 0.4 10.8 5.0 3.9 7.7 0.9 2.2 1 1 1 2 2 2 0 Herpesvirus UL49 tegument protein DUF4743 PF15916.5 EFC35560.1 - 0.084 12.8 0.0 0.13 12.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4743) Ras PF00071.22 EFC35562.1 - 3.8e-26 91.6 0.0 4.6e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC35562.1 - 1.2e-12 48.1 0.0 1.4e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35562.1 - 0.0019 17.7 0.0 0.0019 17.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Oxidored_FMN PF00724.20 EFC35564.1 - 2.4e-63 214.5 0.2 2.9e-63 214.2 0.2 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family SUV3_C PF12513.8 EFC35565.1 - 0.12 12.4 0.0 0.31 11.0 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal MACPF PF01823.19 EFC35566.1 - 0.00016 21.8 0.1 0.00025 21.2 0.1 1.2 1 0 0 1 1 1 1 MAC/Perforin domain TLD PF07534.16 EFC35567.1 - 7.1e-20 71.6 0.7 8.2e-20 71.4 0.7 1.0 1 0 0 1 1 1 1 TLD Kelch_4 PF13418.6 EFC35567.1 - 0.0034 17.3 0.0 0.0062 16.5 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain SR-25 PF10500.9 EFC35568.1 - 0.0029 17.2 6.3 0.0041 16.8 6.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 EFC35568.1 - 0.71 8.6 7.1 0.84 8.3 7.1 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFC35568.1 - 1 8.5 2.8 1.1 8.4 2.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3464 PF11947.8 EFC35568.1 - 7.6 6.3 6.9 15 5.3 6.9 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 HCMV_UL139 PF12507.8 EFC35569.1 - 0.049 14.0 1.1 0.15 12.5 0.0 2.2 2 1 1 3 3 3 0 Human Cytomegalovirus UL139 protein Macoilin PF09726.9 EFC35569.1 - 0.21 10.1 9.4 0.23 10.0 9.4 1.1 1 0 0 1 1 1 0 Macoilin family LRIF1 PF15741.5 EFC35569.1 - 0.33 9.4 13.1 0.39 9.2 11.1 1.7 1 1 1 2 2 2 0 Ligand-dependent nuclear receptor-interacting factor 1 Med26_C PF15693.5 EFC35569.1 - 1.1 9.3 4.9 2.1 8.4 4.9 1.5 1 1 0 1 1 1 0 Mediator complex subunit 26 C-terminal FAM76 PF16046.5 EFC35569.1 - 3 7.1 5.4 4.2 6.6 5.4 1.1 1 0 0 1 1 1 0 FAM76 protein SUZ PF12752.7 EFC35569.1 - 5.2 7.9 8.0 39 5.1 7.8 2.3 1 1 0 1 1 1 0 SUZ domain SSP160 PF06933.11 EFC35569.1 - 9.7 4.2 14.3 12 3.9 14.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DEAD PF00270.29 EFC35570.1 - 1.2e-11 44.8 0.8 2e-11 44.0 0.8 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase TniB PF05621.11 EFC35570.1 - 0.028 13.8 0.2 0.34 10.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein CobA_CobO_BtuR PF02572.15 EFC35570.1 - 0.038 14.2 0.0 0.11 12.8 0.0 1.7 1 1 1 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Alpha_adaptin_C PF02296.16 EFC35572.1 - 6.9e-22 77.8 0.0 1.3e-21 76.8 0.0 1.5 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EFC35572.1 - 2e-12 47.4 0.1 6e-12 45.9 0.0 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain Coatomer_g_Cpla PF16381.5 EFC35572.1 - 0.0041 17.2 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform B2-adapt-app_C PF09066.10 EFC35572.1 - 0.0071 16.4 0.4 0.08 13.0 0.4 2.3 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain DUF1930 PF09122.10 EFC35572.1 - 0.096 12.7 0.3 0.16 12.0 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1930) Aminotran_1_2 PF00155.21 EFC35573.1 - 1.4e-08 34.3 0.0 8.6e-08 31.7 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 EFC35573.1 - 8.7e-05 21.5 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Ntox35 PF15534.6 EFC35574.1 - 0.14 12.6 0.3 0.96 9.9 0.0 2.4 2 0 0 2 2 2 0 Bacterial toxin 35 RGS PF00615.19 EFC35575.1 - 1.4e-10 41.5 3.0 5e-10 39.7 3.0 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain Arg_repressor PF01316.21 EFC35576.1 - 4.7 7.0 12.6 3.9 7.3 0.6 3.0 2 1 1 3 3 3 0 Arginine repressor, DNA binding domain PI3_PI4_kinase PF00454.27 EFC35577.1 - 0.00039 20.3 0.1 0.00072 19.4 0.0 1.5 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase NuA4 PF09340.10 EFC35578.1 - 3.4e-21 74.9 5.1 5.6e-21 74.2 5.1 1.4 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 FAM104 PF15434.6 EFC35578.1 - 0.043 14.4 0.1 0.043 14.4 0.1 2.4 1 1 0 2 2 2 0 Family 104 NUC130_3NT PF08158.12 EFC35579.1 - 0.088 13.1 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 NUC130/3NT domain Kelch_3 PF13415.6 EFC35580.1 - 8.8e-24 83.3 0.9 1.4e-06 28.4 0.0 5.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC35580.1 - 2.9e-22 78.4 5.3 2.1e-06 27.6 0.0 5.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC35580.1 - 4.1e-22 77.7 3.6 2.3e-08 34.0 0.0 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 EFC35580.1 - 3.3e-20 71.6 11.7 6e-05 22.9 0.2 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFC35580.1 - 5.5e-16 57.9 7.1 9e-06 25.2 0.0 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EFC35580.1 - 2e-12 46.5 7.7 1.1e-05 25.2 0.0 5.1 6 0 0 6 6 6 2 Kelch motif F-box PF00646.33 EFC35580.1 - 0.00074 19.3 0.5 0.0016 18.2 0.5 1.5 1 0 0 1 1 1 1 F-box domain cEGF PF12662.7 EFC35581.1 - 0.0063 16.4 1.4 0.0063 16.4 1.4 2.7 3 0 0 3 3 3 1 Complement Clr-like EGF-like NHL PF01436.21 EFC35581.1 - 0.023 14.7 0.0 3.1 8.0 0.0 3.6 3 0 0 3 3 3 0 NHL repeat EGF_2 PF07974.13 EFC35581.1 - 0.038 14.4 11.3 0.038 14.4 11.3 3.5 3 0 0 3 3 3 0 EGF-like domain Pentapeptide PF00805.22 EFC35582.1 - 3.7e-22 77.6 21.4 2.5e-10 39.8 3.7 5.4 4 1 0 5 5 5 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC35582.1 - 2.8e-16 59.5 36.3 1.3e-10 41.3 10.9 4.8 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC35582.1 - 5.9e-12 45.6 23.2 5.9e-06 26.3 0.8 5.6 4 1 1 5 5 5 4 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC35582.1 - 0.00033 20.9 0.6 0.0015 18.9 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain F-protein PF00469.20 EFC35582.1 - 0.044 13.4 0.3 0.086 12.4 0.3 1.5 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef TRAF6_Z2 PF18048.1 EFC35582.1 - 0.79 9.9 8.1 6.1 7.0 1.4 2.8 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 Vfa1 PF08432.10 EFC35582.1 - 0.93 9.8 11.1 1.7 8.9 11.1 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mitofilin PF09731.9 EFC35582.1 - 2.5 6.8 13.8 3.7 6.3 13.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CLZ PF16526.5 EFC35583.1 - 0.00067 20.0 5.5 0.2 12.1 1.6 2.7 1 1 1 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels bZIP_1 PF00170.21 EFC35583.1 - 0.0033 17.5 14.9 0.01 15.9 3.5 3.0 2 1 1 3 3 3 2 bZIP transcription factor APG6_N PF17675.1 EFC35583.1 - 0.011 16.3 10.8 0.011 16.3 10.8 1.9 2 1 0 2 2 2 0 Apg6 coiled-coil region Fez1 PF06818.15 EFC35583.1 - 0.64 10.4 14.3 0.17 12.3 10.7 1.7 1 1 1 2 2 2 0 Fez1 DUF5320 PF17253.2 EFC35583.1 - 4.7 8.3 5.3 9.2 7.4 0.5 2.5 1 1 0 2 2 2 0 Family of unknown function (DUF5320) bZIP_2 PF07716.15 EFC35583.1 - 5.2 7.2 12.5 4.9 7.3 0.7 3.6 2 1 1 3 3 3 0 Basic region leucine zipper CENP-F_leu_zip PF10473.9 EFC35583.1 - 5.6 7.0 19.0 0.063 13.3 7.5 2.8 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 EFC35583.1 - 5.7 7.0 12.1 0.59 10.2 3.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 EFC35583.1 - 6.1 6.3 10.3 8.4 5.9 10.0 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF359 PF04019.12 EFC35587.1 - 0.21 11.3 4.9 15 5.3 0.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF359) Guanylate_kin PF00625.21 EFC35587.1 - 0.46 10.2 5.0 0.2 11.3 1.0 1.9 2 0 0 2 2 2 0 Guanylate kinase Ank_5 PF13857.6 EFC35588.1 - 0.00019 21.6 0.1 0.54 10.6 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC35588.1 - 0.014 15.9 0.2 6.3 7.7 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat DUF2857 PF11198.8 EFC35588.1 - 0.15 11.8 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2857) Kinesin PF00225.23 EFC35589.1 - 2.1e-43 148.5 0.3 2.4e-43 148.4 0.3 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC35589.1 - 3.3e-18 66.0 0.1 4.9e-18 65.5 0.1 1.3 1 0 0 1 1 1 1 Microtubule binding ResIII PF04851.15 EFC35589.1 - 0.47 10.4 4.8 3.1 7.8 0.3 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit RFC1 PF08519.12 EFC35591.1 - 0.042 14.0 0.3 0.059 13.5 0.3 1.4 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain WD40 PF00400.32 EFC35595.1 - 1.5e-05 25.6 2.8 0.16 12.9 0.0 4.2 5 0 0 5 5 5 2 WD domain, G-beta repeat Dynein_AAA_lid PF17852.1 EFC35595.1 - 0.099 12.7 1.2 0.16 12.0 0.1 2.0 3 0 0 3 3 3 0 Dynein heavy chain AAA lid domain Mlf1IP PF10248.9 EFC35596.1 - 4e-07 30.2 34.2 1.1e-05 25.5 34.3 3.2 1 1 0 1 1 1 1 Myelodysplasia-myeloid leukemia factor 1-interacting protein Amidinotransf PF02274.17 EFC35596.1 - 0.11 11.6 4.6 0.19 10.8 4.6 1.4 1 0 0 1 1 1 0 Amidinotransferase AAA-ATPase_like PF09820.9 EFC35597.1 - 7e-46 156.9 0.1 1e-45 156.3 0.1 1.2 1 0 0 1 1 1 1 Predicted AAA-ATPase EGF_2 PF07974.13 EFC35599.1 - 3.3e-31 107.3 197.4 0.00042 20.6 15.1 10.8 9 1 1 10 10 10 10 EGF-like domain EGF PF00008.27 EFC35599.1 - 5.1e-18 65.0 151.7 0.018 15.3 6.7 10.6 10 0 0 10 10 10 10 EGF-like domain hEGF PF12661.7 EFC35599.1 - 4.1e-14 52.6 174.2 0.013 16.1 8.0 12.4 12 0 0 12 12 12 10 Human growth factor-like EGF EB PF01683.18 EFC35599.1 - 0.006 16.8 168.5 2.3 8.6 12.8 10.0 1 1 8 9 9 9 6 EB module DPCD PF14913.6 EFC35600.1 - 7.2e-59 198.3 1.2 9e-59 198.0 1.2 1.1 1 0 0 1 1 1 1 DPCD protein family DUF4116 PF13475.6 EFC35601.1 - 0.0011 18.6 2.9 0.0017 18.0 2.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4116) LpxD PF04613.14 EFC35601.1 - 0.19 11.5 2.1 0.2 11.4 0.5 2.0 2 1 0 2 2 2 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD CDC27 PF09507.10 EFC35601.1 - 0.22 10.9 37.2 0.25 10.7 37.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SWI-SNF_Ssr4 PF08549.10 EFC35601.1 - 8 5.0 19.7 9.6 4.7 19.7 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) TMEM154 PF15102.6 EFC35602.1 - 0.055 13.4 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family PP2 PF14299.6 EFC35604.1 - 1.7e-06 28.1 1.9 4.6e-06 26.7 0.4 2.1 2 0 0 2 2 2 1 Phloem protein 2 F-box-like PF12937.7 EFC35604.1 - 0.0071 16.2 0.1 0.018 14.9 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC35604.1 - 0.012 15.5 0.1 0.025 14.5 0.1 1.6 1 0 0 1 1 1 0 F-box domain WD40 PF00400.32 EFC35605.1 - 0.018 15.9 1.8 3.9 8.5 0.3 4.0 5 0 0 5 5 5 0 WD domain, G-beta repeat Dynein_AAA_lid PF17852.1 EFC35605.1 - 0.024 14.7 1.2 0.044 13.9 0.1 2.0 2 1 0 2 2 2 0 Dynein heavy chain AAA lid domain VIT PF08487.10 EFC35606.1 - 2.9e-18 66.1 0.0 6.9e-18 64.9 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VIT_2 PF13757.6 EFC35606.1 - 0.00042 20.1 0.0 0.00076 19.3 0.0 1.4 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain Nucleo_P87 PF07267.11 EFC35606.1 - 0.13 11.1 6.4 0.16 10.8 6.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Mucin PF01456.17 EFC35606.1 - 2.4 8.1 19.1 3.8 7.5 19.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein PP_M1 PF03012.14 EFC35606.1 - 4.1 6.9 8.0 5.7 6.4 8.0 1.2 1 0 0 1 1 1 0 Phosphoprotein Clr5 PF14420.6 EFC35608.1 - 0.065 13.5 1.4 0.19 12.0 0.3 2.1 2 0 0 2 2 2 0 Clr5 domain OST3_OST6 PF04756.13 EFC35611.1 - 2.3e-12 46.9 0.6 2.7e-12 46.6 0.6 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family SR-25 PF10500.9 EFC35612.1 - 0.015 14.9 9.0 0.019 14.6 9.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM24 PF15193.6 EFC35613.1 - 0.28 12.0 2.6 23 5.8 0.1 2.9 3 0 0 3 3 3 0 FAM24 family TLD PF07534.16 EFC35614.1 - 1.9e-09 37.8 0.3 3.3e-09 37.1 0.3 1.4 1 1 0 1 1 1 1 TLD DUF5089 PF17002.5 EFC35615.1 - 0.04 13.8 2.3 0.056 13.3 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) PTPRCAP PF15713.5 EFC35615.1 - 0.094 13.0 3.1 0.15 12.4 3.1 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DNA_pol_phi PF04931.13 EFC35615.1 - 0.24 9.5 5.6 0.29 9.2 5.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 EFC35615.1 - 0.25 10.9 7.6 0.31 10.6 7.6 1.2 1 0 0 1 1 1 0 PPP4R2 DUF2457 PF10446.9 EFC35615.1 - 0.29 10.2 8.2 0.33 10.1 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 EFC35615.1 - 3.7 6.8 10.1 5.4 6.2 10.1 1.2 1 0 0 1 1 1 0 NOA36 protein DUF3568 PF12092.8 EFC35616.1 - 0.15 12.1 0.2 0.59 10.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3568) Propeptide_C1 PF08127.13 EFC35617.1 - 0.0058 16.5 0.1 0.01 15.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide Condensin2nSMC PF12422.8 EFC35617.1 - 0.1 12.8 0.2 0.45 10.7 0.1 2.1 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit Lipin_mid PF16876.5 EFC35617.1 - 0.2 11.8 2.1 1.3 9.2 0.1 2.7 3 0 0 3 3 3 0 Lipin/Ned1/Smp2 multi-domain protein middle domain Form_Nir_trans PF01226.17 EFC35619.1 - 5.9e-26 91.3 8.2 7.1e-26 91.0 8.2 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter PelG PF16933.5 EFC35619.1 - 0.076 11.9 2.9 0.086 11.7 2.9 1.0 1 0 0 1 1 1 0 Putative exopolysaccharide Exporter (EPS-E) Exo5 PF09810.9 EFC35620.1 - 0.029 13.9 4.9 0.035 13.6 4.9 1.2 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease COesterase PF00135.28 EFC35621.1 - 1.3e-31 110.0 2.2 5.2e-20 71.8 1.7 2.0 2 0 0 2 2 2 2 Carboxylesterase family Zn_clus PF00172.18 EFC35622.1 - 2.2e-07 30.9 15.0 2.2e-07 30.9 15.0 2.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HALZ PF02183.18 EFC35622.1 - 6.7 7.0 7.8 8.8 6.6 0.2 3.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper PRESAN PF09687.10 EFC35623.1 - 0.01 16.4 2.4 0.01 16.4 2.4 2.0 1 1 1 2 2 2 0 Plasmodium RESA N-terminal Nucleoporin2 PF04096.14 EFC35623.1 - 0.17 12.0 3.6 1.5 8.9 1.0 2.6 1 1 1 2 2 2 0 Nucleoporin autopeptidase Pkinase PF00069.25 EFC35624.1 - 0.00061 19.2 1.5 0.003 17.0 0.2 2.5 2 1 0 2 2 2 1 Protein kinase domain LRR_6 PF13516.6 EFC35626.1 - 1.2e-17 62.3 19.1 0.00024 20.9 0.3 6.8 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 EFC35626.1 - 5.8e-08 32.9 28.4 1.4e-05 25.3 1.7 5.4 1 1 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC35626.1 - 6.2e-07 29.1 26.1 2.9e-05 23.8 6.2 4.3 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFC35626.1 - 0.023 15.2 19.8 0.89 10.4 0.2 6.7 7 1 0 7 7 7 0 Leucine Rich Repeat DNMT1-RFD PF12047.8 EFC35626.1 - 0.095 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain TFA2_Winged_2 PF18121.1 EFC35627.1 - 4.6e-12 45.5 0.2 9.8e-12 44.4 0.2 1.6 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 Nexin_C PF08628.12 EFC35627.1 - 4 8.1 8.3 1.9 9.1 1.0 3.0 2 1 1 3 3 3 0 Sorting nexin C terminal HATPase_c PF02518.26 EFC35628.1 - 2.9e-06 27.8 1.5 4.3e-06 27.2 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFC35628.1 - 0.004 17.0 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Elf4 PF07011.11 EFC35628.1 - 0.0062 16.4 1.3 0.031 14.2 1.3 2.2 1 0 0 1 1 1 1 Early Flowering 4 domain Lectin_N PF03954.14 EFC35628.1 - 5.4 6.8 9.3 2.3 8.0 4.3 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Oxidored_FMN PF00724.20 EFC35632.1 - 5.1e-78 262.7 0.0 6.2e-78 262.4 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFC35632.1 - 0.25 10.4 0.1 27 3.7 0.0 2.6 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) Gag_p10 PF02337.17 EFC35633.1 - 0.036 14.0 0.1 0.063 13.2 0.1 1.3 1 0 0 1 1 1 0 Retroviral GAG p10 protein RA PF00788.23 EFC35634.1 - 1.3e-07 32.2 0.3 3.1e-07 30.9 0.1 1.7 1 1 1 2 2 2 1 Ras association (RalGDS/AF-6) domain FERM_N PF09379.10 EFC35634.1 - 1.2e-05 25.2 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 FERM N-terminal domain Peptidase_S15 PF02129.18 EFC35635.1 - 1.4e-37 129.8 0.0 1.6e-37 129.6 0.0 1.0 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 EFC35635.1 - 0.00013 21.7 0.1 0.00016 21.4 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC35635.1 - 0.00014 21.5 0.0 0.00019 21.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFC35635.1 - 0.00022 20.6 0.0 0.00029 20.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PPR_2 PF13041.6 EFC35636.1 - 7.1e-104 339.9 46.7 2.3e-15 56.5 0.3 15.1 9 5 5 14 14 14 11 PPR repeat family PPR PF01535.20 EFC35636.1 - 2.6e-66 215.4 32.9 1.8e-07 31.0 0.0 22.7 23 1 0 23 23 22 10 PPR repeat PPR_3 PF13812.6 EFC35636.1 - 3.9e-60 199.8 37.0 2e-09 37.4 0.1 12.4 10 4 2 12 12 12 11 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC35636.1 - 2.6e-34 116.6 36.9 0.0029 17.3 0.0 17.1 18 0 0 18 18 18 10 PPR repeat PPR_long PF17177.4 EFC35636.1 - 3.6e-30 104.9 6.2 5.2e-06 26.0 0.1 7.2 2 2 3 6 6 6 6 Pentacotripeptide-repeat region of PRORP DYW_deaminase PF14432.6 EFC35636.1 - 9e-27 93.5 2.4 2.8e-26 91.9 0.6 2.8 2 0 0 2 2 2 1 DYW family of nucleic acid deaminases TUG-UBL1 PF11470.8 EFC35636.1 - 1.3e-11 44.6 4.5 0.0042 17.3 0.1 6.0 6 0 0 6 6 5 2 TUG ubiquitin-like domain TPR_19 PF14559.6 EFC35636.1 - 3.1e-08 34.0 0.0 1.9 9.0 0.0 6.7 6 1 0 7 7 7 1 Tetratricopeptide repeat MRP-S27 PF10037.9 EFC35636.1 - 3.8e-07 29.3 5.5 0.091 11.6 0.0 5.5 5 2 2 7 7 7 2 Mitochondrial 28S ribosomal protein S27 ATP13 PF12921.7 EFC35636.1 - 4.2e-06 26.6 14.4 4 7.3 0.0 10.0 7 2 5 12 12 12 1 Mitochondrial ATPase expression PHB_acc PF05233.13 EFC35636.1 - 9.5e-05 22.3 0.1 45 4.2 0.0 6.2 5 0 0 5 5 5 0 PHB accumulation regulatory domain ECSIT PF06239.11 EFC35636.1 - 0.00017 20.8 6.2 2.9 6.9 0.0 6.2 7 1 0 7 7 7 1 Evolutionarily conserved signalling intermediate in Toll pathway TPR_1 PF00515.28 EFC35636.1 - 0.00033 20.3 0.0 15 5.6 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat Ocnus PF05005.15 EFC35636.1 - 0.0028 17.7 0.8 15 5.7 0.0 5.4 7 0 0 7 7 7 0 Janus/Ocnus family (Ocnus) Katanin_con80 PF13925.6 EFC35636.1 - 0.0089 16.1 0.7 2 8.4 0.0 3.5 4 0 0 4 4 4 1 con80 domain of Katanin TPR_8 PF13181.6 EFC35636.1 - 0.045 14.0 2.1 58 4.3 0.0 6.1 8 0 0 8 8 7 0 Tetratricopeptide repeat Uteroglobin PF01099.17 EFC35636.1 - 0.051 13.9 4.6 0.43 11.0 0.1 4.0 3 1 1 4 4 3 0 Uteroglobin family TPR_12 PF13424.6 EFC35636.1 - 0.097 13.0 0.0 8.3 6.8 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC35636.1 - 0.18 12.0 0.0 62 4.1 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Nrap PF03813.14 EFC35636.1 - 0.28 11.2 5.2 19 5.3 0.1 4.5 4 2 0 4 4 4 0 Nrap protein domain 1 Clathrin PF00637.20 EFC35636.1 - 1.1 9.1 21.8 4.1 7.3 0.5 6.9 6 2 2 8 8 8 0 Region in Clathrin and VPS EGF_2 PF07974.13 EFC35637.1 - 4.3e-32 110.1 145.1 5.4e-06 26.7 8.1 9.5 9 0 0 9 9 9 9 EGF-like domain EGF PF00008.27 EFC35637.1 - 0.022 15.1 2.9 0.022 15.1 2.9 10.2 10 0 0 10 10 10 0 EGF-like domain Actin PF00022.19 EFC35638.1 - 3.8e-100 335.4 0.1 2e-99 333.0 0.1 1.8 1 1 0 1 1 1 1 Actin Methyltransf_29 PF03141.16 EFC35638.1 - 0.17 10.4 0.0 0.37 9.3 0.0 1.5 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF2433 PF10360.9 EFC35639.1 - 0.013 15.6 1.1 0.013 15.6 1.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2433) Herpes_UL4 PF03277.13 EFC35639.1 - 0.06 13.0 0.2 0.098 12.3 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus UL4 family ISG65-75 PF11727.8 EFC35639.1 - 0.29 10.3 12.0 0.026 13.8 5.8 1.9 2 0 0 2 2 2 0 Invariant surface glycoprotein MRFAP1 PF15155.6 EFC35639.1 - 0.83 10.2 5.7 0.49 10.9 1.8 2.2 2 0 0 2 2 2 0 MORF4 family-associated protein1 Phage_integrase PF00589.22 EFC35640.1 - 7.7e-05 22.5 0.0 0.00012 21.9 0.0 1.2 1 0 0 1 1 1 1 Phage integrase family HCMV_UL139 PF12507.8 EFC35641.1 - 0.14 12.5 1.7 0.28 11.6 0.1 2.3 3 0 0 3 3 3 0 Human Cytomegalovirus UL139 protein Macoilin PF09726.9 EFC35641.1 - 0.2 10.2 10.1 0.21 10.1 9.6 1.3 1 1 0 1 1 1 0 Macoilin family BTB PF00651.31 EFC35642.1 - 0.00015 22.0 0.0 0.00052 20.2 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain Urocanase PF01175.18 EFC35643.1 - 1.3e-73 247.1 0.3 3.1e-71 239.3 0.3 2.2 1 1 0 1 1 1 1 Urocanase Rossmann-like domain Urocanase_C PF17392.2 EFC35643.1 - 1.9e-31 109.1 0.9 3e-31 108.4 0.0 1.8 2 0 0 2 2 2 1 Urocanase C-terminal domain Urocanase_N PF17391.2 EFC35643.1 - 0.0067 16.1 0.6 0.036 13.8 0.2 2.1 2 0 0 2 2 2 1 Urocanase N-terminal domain RabGAP-TBC PF00566.18 EFC35645.1 - 7.7e-44 149.9 3.8 1.3e-23 83.8 0.0 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain HSP20 PF00011.21 EFC35647.1 - 7.4e-09 35.7 0.9 7.4e-09 35.7 0.9 2.1 2 1 0 2 2 2 1 Hsp20/alpha crystallin family DUF4911 PF16256.5 EFC35648.1 - 0.04 13.9 0.2 0.097 12.7 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) GP88 PF17338.2 EFC35648.1 - 0.1 12.0 0.2 0.16 11.4 0.2 1.2 1 0 0 1 1 1 0 Gene product 88 LRR_8 PF13855.6 EFC35649.1 - 6.1e-17 61.1 2.9 3.8e-06 26.6 0.2 3.6 3 0 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EFC35649.1 - 9.8e-17 59.5 9.4 0.0052 16.7 0.0 7.9 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EFC35649.1 - 1.1e-12 47.9 10.6 0.0048 17.3 0.1 6.3 2 1 5 7 7 7 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC35649.1 - 0.00032 20.5 0.0 0.00074 19.4 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC35649.1 - 0.0074 16.7 6.7 13 6.8 0.0 6.4 6 2 1 7 7 7 1 Leucine Rich Repeat F-box PF00646.33 EFC35649.1 - 0.13 12.2 0.0 0.36 10.8 0.0 1.8 1 0 0 1 1 1 0 F-box domain DUF501 PF04417.12 EFC35650.1 - 0.00021 21.1 0.1 0.00038 20.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF501) IIGP PF05049.13 EFC35651.1 - 0.068 12.2 0.1 0.091 11.8 0.1 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Peptidase_S41 PF03572.18 EFC35652.1 - 4.4e-06 26.4 0.0 1.1e-05 25.1 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 Ephrin_rec_like PF07699.13 EFC35652.1 - 0.15 11.9 9.5 0.063 13.0 6.7 2.0 1 1 0 1 1 1 0 Putative ephrin-receptor like cEGF PF12662.7 EFC35652.1 - 9.2 6.3 7.2 7.3 6.6 0.4 2.7 2 0 0 2 2 2 0 Complement Clr-like EGF-like SGL PF08450.12 EFC35653.1 - 0.045 13.3 0.2 6.3 6.3 0.0 2.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region RINGv PF12906.7 EFC35654.1 - 0.039 14.1 0.2 0.13 12.4 0.2 1.9 1 0 0 1 1 1 0 RING-variant domain ABC2_membrane_3 PF12698.7 EFC35654.1 - 0.04 13.0 1.6 0.095 11.8 1.6 1.6 1 0 0 1 1 1 0 ABC-2 family transporter protein FAD-SLDH PF12318.8 EFC35654.1 - 1.7 8.7 9.6 3.6 7.6 9.6 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF2203 PF09969.9 EFC35654.1 - 8.6 7.1 14.4 19 6.0 12.2 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) CAMSAP_CKK PF08683.11 EFC35655.1 - 0.024 14.8 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated Exo_endo_phos PF03372.23 EFC35657.1 - 4.7e-07 29.6 0.0 8.1e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase_fungal PF17667.1 EFC35658.1 - 0.0067 15.2 0.0 0.009 14.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase NHL PF01436.21 EFC35659.1 - 0.00074 19.4 0.1 0.12 12.5 0.0 2.9 3 0 0 3 3 3 2 NHL repeat AAA PF00004.29 EFC35661.1 - 2.9e-07 31.0 0.0 4.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RCC1 PF00415.18 EFC35663.1 - 8.8e-15 55.1 9.7 8.2e-06 26.4 0.0 5.8 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC35663.1 - 5.4e-11 42.0 20.4 0.0029 17.3 1.2 4.6 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat DUF2862 PF11061.8 EFC35663.1 - 0.059 13.2 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2862) LRR_6 PF13516.6 EFC35664.1 - 1.1e-30 103.1 0.2 0.00025 20.8 0.0 6.4 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC35664.1 - 1.7e-16 59.7 15.5 2.3e-06 27.3 0.6 4.2 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC35664.1 - 7.6e-15 54.8 9.0 0.00026 21.3 0.5 4.7 2 1 4 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35664.1 - 1.7e-08 33.8 0.2 25 6.0 0.0 6.6 7 0 0 7 7 7 0 Leucine Rich Repeat ApoB100_C PF12491.8 EFC35664.1 - 0.00017 21.5 8.3 1.2 9.1 0.2 6.1 1 1 6 7 7 7 2 Apolipoprotein B100 C terminal DUF5490 PF17593.2 EFC35664.1 - 0.0006 19.8 1.9 38 4.4 0.0 6.1 3 2 4 7 7 7 0 Family of unknown function (DUF5490) Apo-VLDL-II PF05418.11 EFC35664.1 - 0.024 15.2 1.0 60 4.3 0.0 4.0 2 1 2 4 4 4 0 Apovitellenin I (Apo-VLDL-II) UPF0193 PF05250.11 EFC35664.1 - 0.077 12.8 9.9 0.74 9.6 0.4 3.0 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0193) 2OG-FeII_Oxy_3 PF13640.6 EFC35665.1 - 0.0026 18.6 0.0 0.0046 17.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DRAT PF07357.11 EFC35665.1 - 0.018 14.2 0.8 0.027 13.6 0.0 1.6 2 0 0 2 2 2 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) LRR_6 PF13516.6 EFC35666.1 - 2.5e-22 77.0 0.0 8.4e-05 22.3 0.0 5.3 5 0 0 5 5 5 5 Leucine Rich repeat LRR_8 PF13855.6 EFC35666.1 - 3.2e-18 65.2 6.1 1e-06 28.4 0.1 2.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC35666.1 - 3.5e-15 55.9 13.2 0.00047 20.5 0.7 3.6 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35666.1 - 6.1e-09 35.2 0.0 9.7 7.2 0.0 5.1 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC35666.1 - 7e-05 22.4 1.3 0.0093 15.5 0.1 2.0 1 1 1 2 2 2 2 Leucine-rich repeat Apo-VLDL-II PF05418.11 EFC35666.1 - 0.00065 20.2 0.1 12 6.5 0.0 3.1 1 1 2 3 3 3 1 Apovitellenin I (Apo-VLDL-II) Beta_helix PF13229.6 EFC35666.1 - 0.0018 18.2 1.1 0.0029 17.5 1.1 1.3 1 0 0 1 1 1 1 Right handed beta helix region Glyco_tranf_2_4 PF13704.6 EFC35666.1 - 0.0031 18.0 0.0 8.2 7.0 0.0 3.0 1 1 2 3 3 3 1 Glycosyl transferase family 2 CAP59_mtransfer PF11735.8 EFC35666.1 - 0.019 14.7 0.7 0.3 10.7 0.7 2.2 1 1 0 1 1 1 0 Cryptococcal mannosyltransferase 1 Arteri_GP4 PF02497.15 EFC35666.1 - 0.054 13.6 0.2 13 5.9 0.0 2.5 1 1 2 3 3 3 0 Arterivirus glycoprotein S-methyl_trans PF02574.16 EFC35669.1 - 1.8e-40 139.5 0.0 5.4e-40 137.9 0.0 1.7 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Exo84_C PF16528.5 EFC35669.1 - 0.058 13.2 0.6 0.29 10.9 0.1 2.3 2 0 0 2 2 2 0 Exocyst component 84 C-terminal DUF3834 PF12916.7 EFC35669.1 - 0.11 11.7 1.2 0.26 10.5 0.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3834) MCM_N PF14551.6 EFC35670.1 - 0.0053 17.3 0.1 0.0093 16.5 0.1 1.4 1 0 0 1 1 1 1 MCM N-terminal domain MCM_OB PF17207.3 EFC35670.1 - 0.057 13.3 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 MCM OB domain G-alpha PF00503.20 EFC35671.1 - 2e-46 158.8 2.8 2.5e-46 158.5 2.8 1.1 1 0 0 1 1 1 1 G-protein alpha subunit DNA_pol_A_exo1 PF01612.20 EFC35671.1 - 0.011 15.5 0.8 0.043 13.5 0.2 2.1 1 1 0 2 2 2 0 3'-5' exonuclease MACPF PF01823.19 EFC35671.1 - 2.8 8.0 8.3 19 5.2 0.0 2.3 2 0 0 2 2 2 0 MAC/Perforin domain DUF956 PF06115.11 EFC35673.1 - 0.045 13.5 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF956) SWIM PF04434.17 EFC35675.1 - 8.6e-05 22.1 1.1 0.00018 21.1 1.1 1.6 1 0 0 1 1 1 1 SWIM zinc finger FlxA PF14282.6 EFC35675.1 - 0.071 13.1 0.8 0.15 12.1 0.8 1.5 1 0 0 1 1 1 0 FlxA-like protein Pkinase PF00069.25 EFC35676.1 - 2.6e-18 66.3 3.9 3.5e-18 65.9 3.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35676.1 - 3.4e-10 39.7 0.3 4.5e-10 39.3 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC35676.1 - 0.00052 19.4 0.1 0.00086 18.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC35676.1 - 0.00063 19.2 0.0 0.00096 18.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFC35676.1 - 0.022 14.4 0.2 0.036 13.6 0.2 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 EFC35676.1 - 0.044 13.7 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family GST_N PF02798.20 EFC35679.1 - 1.8e-18 66.6 0.0 2.4e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC35679.1 - 5.2e-15 55.6 0.0 6.3e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC35679.1 - 4.1e-14 52.6 0.0 5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PSII_Pbs31 PF18240.1 EFC35679.1 - 0.11 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Photosystem II Psb31 protein BTB_2 PF02214.22 EFC35680.1 - 5e-09 36.4 0.1 1.1e-08 35.2 0.1 1.6 1 0 0 1 1 1 1 BTB/POZ domain PIN_12 PF16289.5 EFC35681.1 - 0.0047 17.4 2.3 0.0066 17.0 2.3 1.3 1 0 0 1 1 1 1 PIN domain Zn_clus PF00172.18 EFC35684.1 - 2.8e-08 33.7 10.1 6.1e-08 32.7 10.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EamA PF00892.20 EFC35685.1 - 0.12 12.5 7.9 0.039 14.1 3.4 2.0 2 0 0 2 2 2 0 EamA-like transporter family Pkinase PF00069.25 EFC35686.1 - 1.9e-35 122.5 1.3 2.6e-35 122.1 1.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35686.1 - 5.6e-20 71.7 0.4 7e-20 71.4 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC35686.1 - 5.3e-07 28.8 0.3 3.9e-06 25.9 0.0 2.3 2 1 1 3 3 3 1 Fungal protein kinase APH PF01636.23 EFC35686.1 - 0.00046 20.2 0.1 0.0016 18.4 0.2 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family PIP49_C PF12260.8 EFC35686.1 - 0.002 17.8 0.1 0.0045 16.6 0.0 1.5 2 0 0 2 2 2 1 Protein-kinase domain of FAM69 Kdo PF06293.14 EFC35686.1 - 0.0021 17.5 0.2 0.0034 16.8 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC35686.1 - 0.017 14.5 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DUF1801 PF08818.11 EFC35687.1 - 0.0089 16.5 0.1 0.015 15.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DU1801) MIT PF04212.18 EFC35688.1 - 0.00025 21.1 0.9 0.0005 20.1 0.9 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Cys_rich_CPCC PF14206.6 EFC35688.1 - 0.18 11.6 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Cysteine-rich CPCC BACK PF07707.15 EFC35688.1 - 0.39 10.8 3.3 1.2 9.3 0.1 2.7 3 0 0 3 3 3 0 BTB And C-terminal Kelch PNK3P PF08645.11 EFC35689.1 - 0.0072 16.0 0.7 0.012 15.3 0.7 1.3 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase DUF3173 PF11372.8 EFC35689.1 - 0.045 13.6 1.4 0.076 12.9 0.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3173) PTPlike_phytase PF14566.6 EFC35689.1 - 0.63 10.1 4.2 2.1 8.5 4.1 1.9 1 1 0 1 1 1 0 Inositol hexakisphosphate zf-RING_2 PF13639.6 EFC35690.1 - 5.1e-10 39.5 9.5 7.7e-10 38.9 9.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC35690.1 - 9.1e-09 35.0 5.5 1.5e-08 34.3 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC35690.1 - 8.4e-08 32.0 5.4 1.7e-07 31.0 5.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFC35690.1 - 1.1e-07 32.0 10.1 5.9e-07 29.7 10.1 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFC35690.1 - 4e-07 29.6 4.6 4e-07 29.6 4.6 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFC35690.1 - 8e-06 25.8 5.7 0.00017 21.5 1.8 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFC35690.1 - 4.1e-05 23.4 5.4 7.2e-05 22.6 5.4 1.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFC35690.1 - 0.00012 22.0 5.1 0.00025 21.1 5.2 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 EFC35690.1 - 0.0018 18.4 9.7 0.064 13.4 9.7 2.4 1 1 0 1 1 1 1 FANCL C-terminal domain zf-RING_5 PF14634.6 EFC35690.1 - 0.013 15.5 6.1 0.03 14.3 6.1 1.7 1 1 0 1 1 1 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFC35690.1 - 0.013 15.1 7.0 0.022 14.3 7.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EFC35690.1 - 0.016 15.0 5.0 0.016 15.0 5.0 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EFC35690.1 - 0.017 15.0 6.0 0.065 13.1 6.0 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Sgf11 PF08209.11 EFC35690.1 - 0.025 14.2 0.7 6.6 6.4 0.1 2.6 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) Prok-RING_1 PF14446.6 EFC35690.1 - 0.047 13.6 6.1 2.6 8.0 1.7 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 U-box PF04564.15 EFC35690.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 U-box domain zf-LITAF-like PF10601.9 EFC35690.1 - 0.17 12.2 6.0 0.47 10.7 6.0 1.9 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain zf-Nse PF11789.8 EFC35690.1 - 0.23 11.3 6.2 0.47 10.3 6.2 1.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 EFC35690.1 - 0.29 11.3 8.3 0.12 12.6 2.2 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING YacG PF03884.14 EFC35690.1 - 0.34 10.7 5.8 7.6 6.4 1.6 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-RING_6 PF14835.6 EFC35690.1 - 0.93 9.4 4.6 1.9 8.4 4.6 1.6 1 1 0 1 1 1 0 zf-RING of BARD1-type protein RINGv PF12906.7 EFC35690.1 - 1.2 9.3 11.0 10 6.4 11.1 2.3 1 1 0 1 1 1 0 RING-variant domain zf-Di19 PF05605.12 EFC35690.1 - 1.5 9.2 12.2 9.3 6.6 4.7 3.1 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING-like PF08746.11 EFC35690.1 - 1.8 8.9 9.3 4.2 7.8 9.3 1.7 1 1 0 1 1 1 0 RING-like domain tRNA_edit PF04073.15 EFC35691.1 - 4.8e-08 33.1 0.0 2e-07 31.1 0.0 1.9 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain NADH_u_ox_C PF12853.7 EFC35691.1 - 0.11 12.5 0.1 4.3 7.4 0.0 2.2 2 0 0 2 2 2 0 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit DDE_Tnp_1_7 PF13843.6 EFC35692.1 - 3.4e-15 56.2 8.1 1.3e-14 54.3 8.1 1.8 1 1 0 1 1 1 1 Transposase IS4 DUF4811 PF16069.5 EFC35692.1 - 0.07 13.0 0.0 0.07 13.0 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) CBFD_NFYB_HMF PF00808.23 EFC35693.1 - 1.7e-19 69.9 0.7 2.8e-19 69.2 0.7 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFC35693.1 - 6.5e-10 39.5 0.8 8.2e-10 39.1 0.8 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFC35693.1 - 0.018 15.1 0.1 0.024 14.8 0.1 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DUF3919 PF13057.6 EFC35693.1 - 0.03 13.9 0.3 0.037 13.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) FolB PF02152.18 EFC35693.1 - 0.038 14.5 1.5 0.71 10.4 0.3 2.1 1 1 1 2 2 2 0 Dihydroneopterin aldolase FdhE PF04216.12 EFC35694.1 - 0.16 11.9 1.0 0.24 11.2 1.0 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Ras PF00071.22 EFC35696.1 - 4.9e-07 29.5 0.0 7.7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Ras family NICE-3 PF07406.11 EFC35696.1 - 0.01 15.8 0.2 0.017 15.1 0.2 1.3 1 0 0 1 1 1 0 NICE-3 protein NES_C_h PF18208.1 EFC35698.1 - 0.069 13.4 0.4 0.2 12.0 0.4 1.7 1 0 0 1 1 1 0 Nicking enzyme C-terminal middle helical domain CRAL_TRIO PF00650.20 EFC35699.1 - 2.3e-38 131.4 0.0 3.4e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFC35699.1 - 2.3e-08 34.3 0.0 4.1e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC35699.1 - 3.2e-07 30.4 0.2 6.8e-07 29.4 0.2 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain GCP_C_terminal PF04130.13 EFC35699.1 - 0.019 14.4 0.0 0.025 14.0 0.0 1.1 1 0 0 1 1 1 0 Gamma tubulin complex component C-terminal DUF4368 PF14287.6 EFC35699.1 - 0.045 14.0 0.0 0.095 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) LAX PF15681.5 EFC35701.1 - 0.0056 15.5 0.6 0.0056 15.5 0.6 1.1 1 0 0 1 1 1 1 Lymphocyte activation family X MJ1316 PF04457.12 EFC35702.1 - 7.2e-08 33.1 0.0 1.9e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain SprA-related PF12118.8 EFC35702.1 - 0.13 11.4 2.4 0.2 10.7 2.4 1.2 1 0 0 1 1 1 0 SprA-related family COX16 PF14138.6 EFC35702.1 - 1.4 9.4 7.1 21 5.7 0.1 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 RPN6_N PF18055.1 EFC35703.1 - 0.18 12.2 0.1 0.37 11.1 0.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN6 N-terminal domain Voltage_CLC PF00654.20 EFC35704.1 - 9.8e-17 61.2 20.9 3.5e-08 33.1 0.2 3.1 1 1 2 3 3 3 3 Voltage gated chloride channel Phage_holin_3_6 PF07332.11 EFC35705.1 - 0.18 11.9 2.7 0.24 11.5 2.7 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF5345 PF17280.2 EFC35705.1 - 1.3 9.0 6.8 0.33 11.0 3.5 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5345) Phage_holin_2_4 PF16082.5 EFC35707.1 - 8.9 6.1 9.3 1.3 8.8 0.6 2.5 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like Pkinase PF00069.25 EFC35708.1 - 1.3e-19 70.6 0.0 1.4e-19 70.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35708.1 - 4.5e-10 39.2 0.0 5.4e-10 39.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase BPL_LplA_LipB PF03099.19 EFC35709.1 - 6.5e-07 29.3 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EFC35709.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Guanylate_cyc PF00211.20 EFC35710.1 - 3.6e-16 59.3 1.0 4.8e-16 58.9 1.0 1.2 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_8 PF13855.6 EFC35711.1 - 7.8e-05 22.4 0.1 0.00015 21.4 0.1 1.5 1 0 0 1 1 1 1 Leucine rich repeat Phage_Mu_Gam PF07352.12 EFC35711.1 - 0.11 12.4 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein HATPase_c PF02518.26 EFC35712.1 - 6e-16 58.9 1.3 1.7e-15 57.5 1.3 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC35712.1 - 7.6e-15 54.7 0.0 1.4e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EFC35712.1 - 0.14 12.0 8.1 0.53 10.1 8.1 2.0 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase STT3_PglB_C PF18527.1 EFC35712.1 - 1.9 8.7 10.5 3.3 7.9 4.4 2.5 2 0 0 2 2 2 0 STT3/PglB C-terminal beta-barrel domain DUF4116 PF13475.6 EFC35715.1 - 1e-34 118.0 5.9 3.8e-16 58.5 0.0 4.6 4 1 1 5 5 5 4 Domain of unknown function (DUF4116) DUF3666 PF12408.8 EFC35715.1 - 0.023 13.9 3.4 10 5.4 0.0 4.2 4 0 0 4 4 4 0 Ribose-5-phosphate isomerase DNA_gyraseA_C PF03989.13 EFC35715.1 - 0.05 13.1 0.1 6.5 6.3 0.0 3.4 3 1 1 4 4 4 0 DNA gyrase C-terminal domain, beta-propeller Lgl_C PF08596.10 EFC35715.1 - 0.053 12.2 0.0 0.077 11.7 0.0 1.2 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal Actin PF00022.19 EFC35716.1 - 3.8e-100 335.4 0.1 2e-99 333.0 0.1 1.8 1 1 0 1 1 1 1 Actin Methyltransf_29 PF03141.16 EFC35716.1 - 0.17 10.4 0.0 0.37 9.3 0.0 1.5 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Ank_5 PF13857.6 EFC35717.1 - 8.2e-07 29.2 0.0 0.00082 19.6 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC35717.1 - 9e-06 26.1 0.0 3.3e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC35717.1 - 0.0008 19.9 0.0 0.0038 17.8 0.0 2.2 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC35717.1 - 0.0013 19.0 0.1 0.019 15.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFC35717.1 - 0.0055 17.1 0.0 0.02 15.4 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat Cdc6_C PF09079.11 EFC35719.1 - 0.029 14.4 0.2 0.029 14.4 0.2 1.7 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain Nudix_N_2 PF14803.6 EFC35719.1 - 0.67 9.9 3.6 1.3 9.1 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal zf-ribbon_3 PF13248.6 EFC35719.1 - 1.8 8.1 4.6 0.29 10.6 0.4 1.9 2 0 0 2 2 2 0 zinc-ribbon domain C2 PF00168.30 EFC35720.1 - 2.2e-08 34.3 0.0 6.9e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 C2 domain Pkinase PF00069.25 EFC35721.1 - 1.2e-35 123.2 0.9 1.6e-35 122.8 0.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35721.1 - 3.7e-14 52.6 0.4 5e-14 52.2 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC35721.1 - 8.7e-07 28.2 1.3 1.4e-06 27.5 1.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC35721.1 - 5.2e-06 25.5 0.1 7.9e-06 24.9 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 EFC35721.1 - 0.0011 18.6 2.5 0.0026 17.4 1.9 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 EFC35721.1 - 0.0024 17.3 0.6 0.0042 16.4 0.6 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC35721.1 - 0.005 16.8 0.1 0.007 16.3 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC35721.1 - 0.0065 15.8 0.0 0.025 13.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase PF00069.25 EFC35723.1 - 5.8e-28 98.0 0.5 9.9e-28 97.2 0.5 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35723.1 - 1.5e-17 63.8 0.3 2.6e-17 63.0 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Gln-synt_C PF00120.24 EFC35723.1 - 1.1e-09 37.8 0.1 1.8e-09 37.1 0.1 1.3 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Pkinase_fungal PF17667.1 EFC35723.1 - 4.9e-05 22.3 0.0 9.6e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF2615 PF11027.8 EFC35723.1 - 0.6 10.3 2.9 2.2 8.5 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) Wzy_C_2 PF11846.8 EFC35723.1 - 1.5 8.7 8.1 0.41 10.6 0.5 2.3 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal DUF3043 PF11241.8 EFC35723.1 - 5.1 7.1 15.7 3 7.8 3.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) SSP160 PF06933.11 EFC35725.1 - 1 7.5 12.8 0.97 7.5 12.8 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PBP3 PF18056.1 EFC35725.1 - 8.9 6.5 6.9 8.2 6.6 0.1 2.1 1 1 1 2 2 2 0 Penicillin Binding Protein 3 Domain Profilin PF00235.19 EFC35727.1 - 4e-15 56.2 0.1 5.1e-15 55.9 0.1 1.0 1 0 0 1 1 1 1 Profilin DUF1922 PF09082.10 EFC35727.1 - 0.1 12.9 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) LRR_6 PF13516.6 EFC35729.1 - 1.2e-09 37.4 1.4 0.97 9.7 0.1 5.5 5 0 0 5 5 5 2 Leucine Rich repeat LRR_8 PF13855.6 EFC35729.1 - 1.4e-07 31.1 7.1 6.8e-06 25.7 1.2 3.0 1 1 3 4 4 4 3 Leucine rich repeat Methyltransf_16 PF10294.9 EFC35729.1 - 2.6e-05 24.0 0.0 4.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase LRR_4 PF12799.7 EFC35729.1 - 5.8e-05 23.4 5.1 0.37 11.3 0.7 4.1 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) DUF4347 PF14252.6 EFC35729.1 - 9e-05 22.4 0.1 0.57 10.0 0.0 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF4347) LRR_1 PF00560.33 EFC35729.1 - 0.026 15.0 1.9 34 5.5 0.0 4.4 5 1 0 5 5 5 0 Leucine Rich Repeat Cas6 PF09559.10 EFC35729.1 - 0.047 13.6 0.8 0.1 12.5 0.8 1.5 1 1 0 1 1 1 0 Cas6 Crispr LRR_9 PF14580.6 EFC35729.1 - 0.053 13.0 0.2 0.49 9.9 0.0 2.2 1 1 2 3 3 3 0 Leucine-rich repeat WD40 PF00400.32 EFC35730.1 - 1.8e-07 31.7 3.4 0.015 16.2 0.1 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat eIF2A PF08662.11 EFC35730.1 - 0.008 16.1 0.0 3.3 7.6 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EFC35731.1 - 5.2e-08 32.6 0.0 8.4e-08 31.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC35731.1 - 0.028 14.3 0.0 0.064 13.1 0.0 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif Exo_endo_phos PF03372.23 EFC35732.1 - 4e-09 36.3 0.0 8.7e-09 35.2 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ku_C PF03730.14 EFC35733.1 - 3.9e-14 53.1 30.8 2.2e-10 41.1 30.2 3.2 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 EFC35733.1 - 5.9e-10 38.7 0.3 5.9e-10 38.7 0.3 2.2 2 0 0 2 2 2 1 SAP domain Ku PF02735.16 EFC35733.1 - 6.6e-07 29.2 0.3 6.6e-07 29.2 0.3 2.6 2 1 0 2 2 2 1 Ku70/Ku80 beta-barrel domain CDC45 PF02724.14 EFC35733.1 - 0.17 10.2 18.7 13 4.0 0.0 2.4 2 1 0 2 2 2 0 CDC45-like protein Apc15p PF05841.11 EFC35733.1 - 6.6 7.6 15.2 2 9.2 3.1 2.6 2 0 0 2 2 2 0 Apc15p protein Intein_splicing PF14890.6 EFC35734.1 - 0.023 14.6 0.0 2 8.4 0.0 2.9 1 1 0 2 2 2 0 Intein splicing domain PSII PF00421.19 EFC35734.1 - 0.22 10.1 0.6 0.35 9.5 0.6 1.2 1 0 0 1 1 1 0 Photosystem II protein Sec62 PF03839.16 EFC35735.1 - 0.0011 18.5 0.8 0.0011 18.5 0.8 2.1 2 0 0 2 2 2 1 Translocation protein Sec62 Surp PF01805.20 EFC35735.1 - 0.03 14.3 0.2 2.1 8.4 0.4 2.8 2 0 0 2 2 2 0 Surp module CDC45 PF02724.14 EFC35735.1 - 0.21 9.9 14.4 0.34 9.1 14.4 1.4 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 EFC35735.1 - 0.52 9.6 25.3 0.66 9.3 25.3 1.0 1 0 0 1 1 1 0 BUD22 Aldo_ket_red PF00248.21 EFC35736.1 - 2.6e-14 53.1 0.0 2.9e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family START PF01852.19 EFC35737.1 - 2.1e-19 69.7 0.1 2.8e-19 69.4 0.1 1.2 1 0 0 1 1 1 1 START domain SIR2 PF02146.17 EFC35738.1 - 9.7e-19 68.0 0.5 9.7e-12 45.2 0.1 3.3 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 EFC35738.1 - 0.0017 18.1 0.0 0.12 12.1 0.0 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Goodbye PF17109.5 EFC35738.1 - 0.038 14.4 0.1 0.09 13.2 0.1 1.6 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain DNA_pol_delta_4 PF04081.13 EFC35738.1 - 1.3 9.3 5.0 3.2 8.1 3.4 2.1 2 0 0 2 2 2 0 DNA polymerase delta, subunit 4 Peptidase_C1 PF00112.23 EFC35739.1 - 1.6e-51 175.5 6.7 2e-51 175.2 6.7 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC35739.1 - 2.9e-06 26.3 1.4 0.042 12.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC35739.1 - 0.00012 21.9 0.1 0.00027 20.7 0.1 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide NTP_transferase PF00483.23 EFC35740.1 - 6.2e-13 48.9 0.1 9e-11 41.8 0.1 2.3 1 1 0 1 1 1 1 Nucleotidyl transferase NHL PF01436.21 EFC35741.1 - 4.6e-07 29.6 0.1 0.0015 18.5 0.1 3.0 2 0 0 2 2 2 2 NHL repeat PTase_Orf2 PF11468.8 EFC35742.1 - 0.002 17.6 0.0 0.0037 16.7 0.0 1.4 1 0 0 1 1 1 1 Aromatic prenyltransferase Orf2 DUF1660 PF07874.11 EFC35742.1 - 0.0068 16.9 0.3 0.061 13.8 0.0 2.7 2 1 0 2 2 2 1 Prophage protein (DUF1660) T6SS_VasJ PF16989.5 EFC35742.1 - 0.057 12.9 0.1 0.084 12.3 0.1 1.2 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ 2OG-FeII_Oxy_2 PF13532.6 EFC35743.1 - 5.5e-24 85.4 0.1 7.2e-24 85.1 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Exo_endo_phos PF03372.23 EFC35744.1 - 9.6e-06 25.3 0.1 0.0016 18.0 0.0 2.1 1 1 1 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFC35744.1 - 0.0053 16.6 0.0 0.57 10.0 0.0 2.1 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase Cnn_1N PF07989.11 EFC35745.1 - 6.4 7.0 7.6 0.27 11.4 0.5 2.5 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 EGF_Tenascin PF18720.1 EFC35746.1 - 0.00014 21.8 9.6 0.00023 21.1 9.6 1.4 1 0 0 1 1 1 1 Tenascin EGF domain EGF_2 PF07974.13 EFC35746.1 - 0.00042 20.6 10.7 0.00078 19.8 10.7 1.5 1 0 0 1 1 1 1 EGF-like domain ECSCR PF15820.5 EFC35746.1 - 0.019 14.8 0.3 0.028 14.3 0.3 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator hEGF PF12661.7 EFC35746.1 - 0.023 15.3 2.8 0.023 15.3 2.8 1.9 2 1 0 2 2 2 0 Human growth factor-like EGF TMEM154 PF15102.6 EFC35746.1 - 0.051 13.5 0.1 0.06 13.3 0.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family Sigma_reg_N PF13800.6 EFC35746.1 - 0.095 13.0 1.5 0.17 12.2 1.5 1.4 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Tmemb_9 PF05434.11 EFC35746.1 - 0.097 12.6 0.8 0.12 12.3 0.8 1.3 1 0 0 1 1 1 0 TMEM9 OppC_N PF12911.7 EFC35746.1 - 0.13 12.2 3.2 0.23 11.5 3.2 1.3 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Insulin_TMD PF17870.1 EFC35746.1 - 0.22 11.6 10.0 0.44 10.6 10.0 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment ASFV_J13L PF05568.11 EFC35746.1 - 9.8 5.9 7.4 0.44 10.3 1.2 1.8 2 0 0 2 2 2 0 African swine fever virus J13L protein Ank_2 PF12796.7 EFC35747.1 - 3.7e-13 49.9 0.1 1.1e-12 48.4 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC35747.1 - 6.6e-10 38.4 0.1 0.00027 21.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC35747.1 - 2e-09 37.8 0.2 2.8e-05 24.6 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC35747.1 - 9.6e-08 32.2 0.1 0.0088 16.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFC35747.1 - 1.5e-07 31.5 0.0 0.0059 16.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) APG6_N PF17675.1 EFC35747.1 - 0.0072 16.9 6.0 0.0072 16.9 6.0 3.2 3 0 0 3 3 3 1 Apg6 coiled-coil region DUF1729 PF08354.10 EFC35747.1 - 0.045 12.6 0.2 0.094 11.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Pullulanase_Ins PF18494.1 EFC35747.1 - 0.055 13.9 2.5 0.13 12.7 0.1 2.7 2 1 1 3 3 3 0 Pullulanase Ins domain DUF4062 PF13271.6 EFC35747.1 - 1.7 9.1 4.2 30 5.1 1.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) PTRF_SDPR PF15237.6 EFC35747.1 - 3.7 7.1 23.2 0.086 12.5 9.7 2.3 2 0 0 2 2 2 0 PTRF/SDPR family WD40 PF00400.32 EFC35748.1 - 9.2e-06 26.3 1.3 1.2 10.1 0.1 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ZT_dimer PF16916.5 EFC35750.1 - 1.2e-09 38.2 0.0 2.1e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Cation_efflux PF01545.21 EFC35750.1 - 5.7e-09 36.0 3.8 8.2e-09 35.5 3.8 1.4 1 0 0 1 1 1 1 Cation efflux family AT_hook PF02178.19 EFC35751.1 - 0.42 10.6 7.7 0.95 9.6 7.7 1.6 1 0 0 1 1 1 0 AT hook motif Macoilin PF09726.9 EFC35751.1 - 1.5 7.3 21.4 1.7 7.1 21.4 1.1 1 0 0 1 1 1 0 Macoilin family RGS PF00615.19 EFC35753.1 - 9.9e-08 32.3 4.8 2.7e-07 30.9 4.3 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain SR-25 PF10500.9 EFC35753.1 - 0.012 15.2 2.2 0.012 15.2 2.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PAPS_reduct PF01507.19 EFC35753.1 - 0.054 13.5 1.6 0.071 13.1 0.7 1.6 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family RCC1 PF00415.18 EFC35755.1 - 1.7e-39 134.2 0.2 5.2e-07 30.2 0.0 8.7 7 1 1 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC35755.1 - 1.2e-32 111.0 9.3 1.8e-10 40.3 0.0 6.1 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC35755.1 - 0.072 13.3 0.0 16 5.8 0.1 3.7 3 2 0 3 3 3 0 Putative heavy-metal chelation PKcGMP_CC PF16808.5 EFC35755.1 - 0.27 11.1 2.9 4.8 7.1 0.9 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sterile PF03015.19 EFC35755.1 - 0.28 11.4 2.5 9.4 6.5 0.4 2.6 1 1 1 2 2 2 0 Male sterility protein Terpene_synth_C PF03936.16 EFC35757.1 - 8.3e-05 22.1 2.3 0.00026 20.4 1.2 2.3 1 1 1 2 2 2 1 Terpene synthase family, metal binding domain Peptidase_C1 PF00112.23 EFC35758.1 - 7.3e-16 58.9 0.6 1.2e-15 58.2 0.6 1.3 1 0 0 1 1 1 1 Papain family cysteine protease Actin PF00022.19 EFC35759.1 - 3.9e-25 88.3 0.4 5.2e-19 68.1 0.1 2.0 1 1 1 2 2 2 2 Actin NHL PF01436.21 EFC35761.1 - 2.6e-19 68.2 5.2 0.00012 21.9 0.1 6.0 6 0 0 6 6 6 5 NHL repeat SGL PF08450.12 EFC35761.1 - 0.00026 20.7 0.2 9.5 5.7 0.0 3.5 2 2 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region Fmp27_WPPW PF10359.9 EFC35762.1 - 0.00045 19.2 0.8 0.00077 18.4 0.8 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain TMPIT PF07851.13 EFC35762.1 - 0.0042 16.4 2.3 0.007 15.6 2.3 1.3 1 0 0 1 1 1 1 TMPIT-like protein DUF3450 PF11932.8 EFC35762.1 - 0.0088 15.4 2.2 0.0088 15.4 2.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) DUF4988 PF16378.5 EFC35762.1 - 0.009 15.7 0.5 0.009 15.7 0.5 1.9 2 0 0 2 2 2 1 Domain of unknown function Peptidase_S49_N PF08496.10 EFC35762.1 - 0.0095 16.0 3.2 0.0096 16.0 1.5 1.8 2 0 0 2 2 2 1 Peptidase family S49 N-terminal DivIC PF04977.15 EFC35762.1 - 0.023 14.5 1.6 0.05 13.4 1.6 1.6 1 0 0 1 1 1 0 Septum formation initiator Atg14 PF10186.9 EFC35762.1 - 0.025 13.7 3.0 0.04 13.0 3.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 EFC35762.1 - 0.027 14.7 4.0 0.084 13.1 4.0 1.8 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PilJ PF13675.6 EFC35762.1 - 0.094 12.7 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF2203 PF09969.9 EFC35762.1 - 0.26 12.0 1.8 0.34 11.6 0.6 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) YlqD PF11068.8 EFC35762.1 - 0.69 10.3 8.4 1.9 8.8 8.4 1.7 1 1 0 1 1 1 0 YlqD protein Spc7 PF08317.11 EFC35762.1 - 5.1 5.9 12.2 0.13 11.1 5.0 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Pec_lyase PF09492.10 EFC35763.1 - 0.19 11.0 0.0 0.49 9.7 0.0 1.6 1 1 1 2 2 2 0 Pectic acid lyase F-box-like PF12937.7 EFC35764.1 - 0.00015 21.6 0.1 0.00035 20.4 0.0 1.7 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 EFC35764.1 - 0.066 12.8 0.2 0.38 10.3 0.1 2.3 2 0 0 2 2 2 0 F-box Ras PF00071.22 EFC35765.1 - 4.3e-29 101.2 0.2 7.3e-29 100.5 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC35765.1 - 4.8e-11 42.9 0.0 9.1e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35765.1 - 1.5e-09 37.5 0.0 2.9e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC35765.1 - 5.8e-09 35.8 0.1 1.1e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC35765.1 - 2.9e-06 27.3 0.2 0.00069 19.6 0.2 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC35765.1 - 0.00013 22.0 0.0 0.00026 21.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC35765.1 - 0.0057 16.5 0.3 0.027 14.3 0.1 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 EFC35765.1 - 0.0088 15.4 1.0 0.024 14.0 1.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFC35765.1 - 0.018 14.3 2.9 1.5 7.9 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit ParA PF10609.9 EFC35765.1 - 0.12 11.8 0.5 4.6 6.6 0.0 2.2 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase EGF_2 PF07974.13 EFC35767.1 - 1.6e-22 79.6 91.6 1.5e-06 28.4 9.0 7.8 7 0 0 7 7 7 7 EGF-like domain EGF PF00008.27 EFC35767.1 - 2.6e-07 30.8 63.7 0.00084 19.6 2.2 8.0 7 0 0 7 7 7 7 EGF-like domain OppC_N PF12911.7 EFC35767.1 - 2.5 8.2 4.7 4.8 7.2 4.7 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF346 PF03984.13 EFC35767.1 - 5.1 6.9 7.4 31 4.4 0.0 4.5 7 0 0 7 7 7 0 Repeat of unknown function (DUF346) F-box PF00646.33 EFC35768.1 - 0.043 13.7 0.9 0.9 9.5 0.1 3.3 3 0 0 3 3 3 0 F-box domain F-box-like PF12937.7 EFC35768.1 - 0.19 11.6 0.6 1.5 8.8 0.1 2.4 2 0 0 2 2 2 0 F-box-like Macoilin PF09726.9 EFC35769.1 - 2 6.9 20.9 2.6 6.5 20.9 1.2 1 0 0 1 1 1 0 Macoilin family CaM_binding PF07839.11 EFC35769.1 - 3.3 8.5 5.4 0.7 10.7 0.1 2.4 2 1 1 3 3 3 0 Plant calmodulin-binding domain Shisa PF13908.6 EFC35770.1 - 0.013 15.7 2.3 0.013 15.7 2.3 3.1 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator p450 PF00067.22 EFC35770.1 - 0.034 12.9 5.1 0.028 13.2 3.7 1.5 1 1 0 1 1 1 0 Cytochrome P450 Dak2 PF02734.17 EFC35770.1 - 1.1 9.2 3.8 6.4 6.6 1.4 2.3 1 1 1 2 2 2 0 DAK2 domain RecJ_OB PF17768.1 EFC35771.1 - 0.12 12.6 2.6 1.2 9.4 0.4 2.6 2 0 0 2 2 2 0 RecJ OB domain ubiquitin PF00240.23 EFC35772.1 - 5.4e-63 208.7 7.1 5.3e-32 109.4 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC35772.1 - 3.2e-29 100.5 7.8 3.6e-15 55.6 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC35772.1 - 6.6e-10 39.3 4.5 0.00027 21.3 0.8 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC35772.1 - 7.8e-09 35.6 0.4 0.0021 18.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC35772.1 - 7.9e-09 35.3 0.6 0.0022 17.9 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFC35772.1 - 8.4e-08 32.7 0.1 0.0022 18.6 0.0 2.2 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC35772.1 - 1.6e-07 31.6 2.3 0.0075 16.6 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC35772.1 - 9e-05 22.4 8.1 3.7 7.7 0.2 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain DUF3861 PF12977.7 EFC35772.1 - 0.024 14.8 0.3 2.4 8.4 0.0 2.4 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) PI3K_p85B PF02192.16 EFC35772.1 - 0.028 14.2 0.7 2.3 8.0 0.1 2.4 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain PilN_bio_d PF18222.1 EFC35772.1 - 0.072 13.5 0.1 2.8 8.4 0.0 2.1 2 0 0 2 2 2 0 PilN biogenesis protein dimerization domain bPH_3 PF14470.6 EFC35772.1 - 0.18 12.2 2.0 4.7 7.6 0.3 2.9 3 0 0 3 3 3 0 Bacterial PH domain DUF2122 PF09895.9 EFC35773.1 - 0.021 15.2 1.0 0.032 14.6 1.0 1.4 1 0 0 1 1 1 0 RecB-family nuclease (DUF2122) Prefoldin_2 PF01920.20 EFC35773.1 - 0.028 14.3 0.4 0.028 14.3 0.4 2.4 1 1 0 2 2 2 0 Prefoldin subunit Oxidored_q6 PF01058.22 EFC35773.1 - 0.035 14.0 0.2 0.045 13.6 0.2 1.1 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit AAA_14 PF13173.6 EFC35773.1 - 0.045 13.8 0.3 0.054 13.5 0.3 1.2 1 0 0 1 1 1 0 AAA domain Methyltrn_RNA_4 PF09936.9 EFC35773.1 - 0.049 13.5 0.1 0.062 13.2 0.1 1.1 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase MKRN1_C PF15815.5 EFC35773.1 - 1.5 9.3 5.5 7.3 7.1 0.4 2.6 1 1 2 3 3 3 0 E3 ubiquitin-protein ligase makorin-1, C-terminal Pkinase PF00069.25 EFC35774.1 - 1.7e-27 96.4 0.6 3.1e-27 95.6 0.6 1.4 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 EFC35774.1 - 5.9e-17 62.0 1.0 1.4e-08 35.2 0.3 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFC35774.1 - 7.4e-14 51.7 0.0 1.6e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFC35774.1 - 3.2e-13 48.5 2.7 0.14 12.8 0.0 6.6 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 EFC35774.1 - 7e-13 48.5 1.8 0.0052 17.1 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC35774.1 - 1.7e-08 34.9 0.4 0.045 14.3 0.0 4.1 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC35774.1 - 5.2e-06 26.7 0.0 0.82 10.2 0.0 4.2 3 0 0 3 3 3 2 Ankyrin repeat Pkinase_fungal PF17667.1 EFC35774.1 - 0.00083 18.2 0.0 0.0014 17.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC35774.1 - 0.0016 17.9 0.1 0.0053 16.1 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC35774.1 - 0.012 15.0 0.2 0.026 13.8 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Aldo_ket_red PF00248.21 EFC35775.1 - 1.4e-82 277.2 0.0 1.6e-82 277.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MMS19_C PF12460.8 EFC35776.1 - 0.0044 16.2 2.6 0.0045 16.2 2.6 1.1 1 0 0 1 1 1 1 RNAPII transcription regulator C-terminal DUF2624 PF11116.8 EFC35776.1 - 0.14 13.0 7.1 0.63 11.0 7.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2624) CH PF00307.31 EFC35778.1 - 1.1e-12 48.1 0.0 2.2e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFC35778.1 - 0.0092 15.8 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain SRI PF08236.11 EFC35778.1 - 0.13 12.4 1.2 8.3 6.7 0.0 3.1 3 0 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain Bombolitin PF08096.11 EFC35778.1 - 2.9 8.4 4.9 3.3 8.2 0.2 3.1 3 0 0 3 3 3 0 Bombolitin family Pkinase PF00069.25 EFC35779.1 - 3e-22 79.3 0.2 6.5e-22 78.1 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Peptidase_C97 PF05903.14 EFC35779.1 - 2.4e-10 40.4 0.5 0.00072 19.4 0.0 2.8 2 0 0 2 2 2 2 PPPDE putative peptidase domain Pkinase_Tyr PF07714.17 EFC35779.1 - 1.5e-09 37.5 0.0 2.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase LRAT PF04970.13 EFC35779.1 - 4.4e-05 23.8 2.2 0.54 10.6 0.2 3.4 2 1 1 3 3 3 2 Lecithin retinol acyltransferase Kdo PF06293.14 EFC35779.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF778 PF05608.12 EFC35779.1 - 0.1 13.0 0.3 1.4 9.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF778) p53-inducible11 PF14936.6 EFC35780.1 - 0.13 12.3 4.0 0.16 12.0 4.0 1.1 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 RGS PF00615.19 EFC35782.1 - 4.2e-11 43.2 1.2 9e-11 42.1 1.2 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain DicB PF05358.11 EFC35782.1 - 0.076 13.2 0.1 0.14 12.3 0.1 1.4 1 0 0 1 1 1 0 DicB protein DUF2663 PF10864.8 EFC35783.1 - 9 6.7 11.4 0.34 11.3 3.9 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2663) Pox_Ag35 PF03286.14 EFC35785.1 - 0.0045 16.8 3.8 0.014 15.2 3.8 1.8 1 0 0 1 1 1 1 Pox virus Ag35 surface protein Amnionless PF14828.6 EFC35787.1 - 0.56 9.0 2.4 0.33 9.7 0.1 1.8 2 0 0 2 2 2 0 Amnionless DUF4419 PF14388.6 EFC35790.1 - 2.3e-65 221.0 0.5 2.6e-65 220.8 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) WD40 PF00400.32 EFC35790.1 - 2.9 8.9 5.7 12 7.0 4.1 2.3 1 1 1 2 2 2 0 WD domain, G-beta repeat Sel1 PF08238.12 EFC35791.1 - 8.2e-30 102.6 11.4 7.5e-08 32.8 0.7 5.1 5 0 0 5 5 5 5 Sel1 repeat TPR_7 PF13176.6 EFC35791.1 - 0.086 12.9 3.5 16 5.8 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat HELP PF03451.14 EFC35792.1 - 4.6e-09 36.0 0.0 7.8e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 EFC35792.1 - 5.2e-08 33.4 0.2 0.00011 22.9 0.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat HsbA PF12296.8 EFC35793.1 - 0.063 13.7 0.0 0.096 13.1 0.0 1.2 1 0 0 1 1 1 0 Hydrophobic surface binding protein A Band_3_cyto PF07565.13 EFC35794.1 - 0.021 14.6 2.6 0.03 14.2 2.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ndc1_Nup PF09531.10 EFC35794.1 - 0.03 13.0 3.4 0.03 13.0 3.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mem_trans PF03547.18 EFC35794.1 - 0.37 9.1 1.4 0.36 9.2 1.4 1.2 1 0 0 1 1 1 0 Membrane transport protein Zip PF02535.22 EFC35794.1 - 0.66 9.1 2.3 0.79 8.9 2.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PNISR PF15996.5 EFC35794.1 - 0.75 10.0 15.8 1.1 9.5 15.8 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PARM PF17061.5 EFC35794.1 - 1.1 9.3 11.8 1.9 8.6 11.8 1.3 1 0 0 1 1 1 0 PARM DUF5427 PF10310.9 EFC35794.1 - 1.3 7.8 15.2 1.9 7.3 15.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) NAD_binding_2 PF03446.15 EFC35795.1 - 1.4e-42 145.5 0.6 2.2e-42 144.9 0.6 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFC35795.1 - 6.7e-31 107.1 0.1 1.1e-30 106.4 0.1 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EFC35795.1 - 9.9e-08 32.5 0.1 2.1e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EFC35795.1 - 1e-06 28.9 0.0 1.8e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFC35795.1 - 1.9e-05 24.1 0.0 3.2e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFC35795.1 - 0.0043 16.4 0.3 0.0079 15.5 0.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EFC35795.1 - 0.0079 16.1 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Folate_rec PF03024.14 EFC35796.1 - 2.1e-07 31.0 10.0 6.2e-07 29.4 7.5 2.4 1 1 1 2 2 2 1 Folate receptor family Oxidored_FMN PF00724.20 EFC35798.1 - 1.6e-52 178.9 0.0 1.9e-52 178.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family PEPCK_ATP PF01293.20 EFC35800.1 - 9.7e-39 133.3 0.0 1.2e-38 133.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase dsRBD2 PF17842.1 EFC35801.1 - 7 6.8 8.7 2.2 8.5 2.2 2.0 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 Acetyltransf_2 PF00797.17 EFC35802.1 - 6.6e-28 98.1 0.0 1.4e-27 97.1 0.0 1.5 1 1 0 1 1 1 1 N-acetyltransferase DUF4116 PF13475.6 EFC35803.1 - 1.8e-22 78.8 5.9 1.5e-13 50.3 0.1 4.8 5 0 0 5 5 5 3 Domain of unknown function (DUF4116) DUF2018 PF09442.10 EFC35803.1 - 0.0077 17.2 0.2 0.024 15.6 0.2 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF2018) KH_8 PF17903.1 EFC35803.1 - 0.14 12.3 0.8 0.49 10.5 0.4 2.1 1 1 1 2 2 2 0 Krr1 KH1 domain Ank_2 PF12796.7 EFC35804.1 - 9.1e-17 61.4 5.0 4.1e-14 52.9 0.8 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC35804.1 - 2.4e-12 45.9 4.5 0.0013 19.1 0.0 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFC35804.1 - 8.4e-09 35.8 0.1 5.4e-07 30.0 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC35804.1 - 6.6e-08 32.7 0.5 0.11 12.9 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC35804.1 - 8e-08 32.4 4.3 0.02 15.3 0.0 4.0 3 1 0 3 3 3 3 Ankyrin repeat RhoGEF PF00621.20 EFC35805.1 - 1.6e-16 61.1 2.4 2.1e-16 60.7 2.4 1.2 1 0 0 1 1 1 1 RhoGEF domain SOG2 PF10428.9 EFC35805.1 - 0.0048 16.2 6.2 0.0055 16.0 6.2 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein ABC2_membrane PF01061.24 EFC35806.1 - 5.3e-10 39.1 12.8 5.3e-10 39.1 12.8 2.0 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 EFC35806.1 - 0.033 13.3 17.4 0.054 12.6 17.4 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF4064 PF13273.6 EFC35806.1 - 0.43 10.9 6.9 6.6 7.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) PufQ PF05398.11 EFC35806.1 - 3.8 7.7 5.0 1.1 9.4 0.4 2.4 2 1 1 3 3 3 0 PufQ cytochrome subunit BTB PF00651.31 EFC35807.1 - 0.00025 21.3 0.0 0.00065 19.9 0.0 1.7 1 1 0 1 1 1 1 BTB/POZ domain EF-hand_7 PF13499.6 EFC35807.1 - 1.2 9.6 5.0 7 7.2 0.8 3.6 4 0 0 4 4 4 0 EF-hand domain pair Hydrolase_like PF13242.6 EFC35808.1 - 1.3e-18 66.9 0.0 1.5e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 HAD-hyrolase-like DEAD PF00270.29 EFC35809.1 - 1.4e-34 119.4 0.3 1.7e-34 119.1 0.3 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC35809.1 - 4.9e-05 23.4 0.0 9.2e-05 22.5 0.0 1.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFC35809.1 - 0.0014 18.0 1.1 0.002 17.5 0.1 1.7 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 EFC35809.1 - 0.0039 17.5 0.1 0.0062 16.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFC35809.1 - 0.005 16.6 0.0 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EFC35809.1 - 0.033 14.0 0.0 0.051 13.4 0.0 1.2 1 0 0 1 1 1 0 Helicase AAA-ATPase_like PF09820.9 EFC35810.1 - 4.6e-23 82.0 0.2 4.6e-23 82.0 0.2 2.2 3 0 0 3 3 3 1 Predicted AAA-ATPase RecO_N_2 PF13114.6 EFC35810.1 - 0.13 12.0 0.2 0.59 9.9 0.0 2.2 2 0 0 2 2 2 0 RecO N terminal Synaptobrevin PF00957.21 EFC35811.1 - 0.034 13.9 1.0 0.073 12.9 1.0 1.5 1 0 0 1 1 1 0 Synaptobrevin Calreticulin PF00262.18 EFC35812.1 - 1.1e-31 110.0 14.7 1.3e-31 109.8 14.7 1.0 1 0 0 1 1 1 1 Calreticulin family DYW_deaminase PF14432.6 EFC35814.1 - 4e-26 91.4 0.4 7.2e-26 90.5 0.4 1.3 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases PPR PF01535.20 EFC35814.1 - 4.2e-06 26.6 0.1 0.017 15.3 0.0 3.0 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.6 EFC35814.1 - 0.00073 19.7 0.0 0.0058 16.8 0.0 2.4 1 1 1 2 2 2 1 PPR repeat family PPR_2 PF13041.6 EFC35815.1 - 1.4e-19 70.0 1.8 4.3e-07 30.0 0.1 4.4 3 1 1 4 4 4 4 PPR repeat family PPR PF01535.20 EFC35815.1 - 9.7e-19 66.2 6.9 5e-06 26.4 0.1 5.8 6 0 0 6 6 6 4 PPR repeat PPR_3 PF13812.6 EFC35815.1 - 1.6e-08 34.5 0.8 7e-05 22.8 0.0 4.1 3 1 0 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC35815.1 - 0.03 14.0 0.1 3.4 7.5 0.0 3.5 4 0 0 4 4 4 0 PPR repeat Phage_integrase PF00589.22 EFC35816.1 - 0.00033 20.5 0.0 0.00084 19.2 0.0 1.6 1 0 0 1 1 1 1 Phage integrase family Macoilin PF09726.9 EFC35816.1 - 0.05 12.2 5.9 0.058 11.9 5.9 1.2 1 0 0 1 1 1 0 Macoilin family NHL PF01436.21 EFC35817.1 - 1.8e-09 37.2 3.4 0.00072 19.5 0.1 4.2 5 0 0 5 5 5 2 NHL repeat RHSP PF07999.11 EFC35817.1 - 0.065 12.0 0.1 0.093 11.5 0.1 1.1 1 0 0 1 1 1 0 Retrotransposon hot spot protein DUF851 PF05867.11 EFC35818.1 - 0.0031 17.0 0.3 0.0038 16.7 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF851) Pkip-1 PF06878.11 EFC35818.1 - 0.041 14.0 0.9 0.043 13.9 0.9 1.2 1 0 0 1 1 1 0 Pkip-1 protein Requiem_N PF14051.6 EFC35818.1 - 0.077 13.2 0.0 1.6 9.0 0.0 2.1 2 0 0 2 2 2 0 N-terminal domain of DPF2/REQ. Ig_GlcNase PF18368.1 EFC35818.1 - 0.11 12.7 0.0 2.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Exo-beta-D-glucosaminidase Ig-fold domain DUF5050 PF16472.5 EFC35819.1 - 0.017 14.4 0.2 0.02 14.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5050) Trypsin_2 PF13365.6 EFC35820.1 - 0.0032 18.4 0.0 0.0069 17.3 0.0 1.6 1 1 0 1 1 1 1 Trypsin-like peptidase domain p450 PF00067.22 EFC35821.1 - 9.9e-24 83.9 0.4 1.4e-23 83.4 0.4 1.2 1 0 0 1 1 1 1 Cytochrome P450 EF-hand_1 PF00036.32 EFC35821.1 - 0.034 13.7 1.1 0.16 11.6 0.0 2.8 3 0 0 3 3 3 0 EF hand C2 PF00168.30 EFC35821.1 - 0.045 14.1 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 C2 domain EF-hand_6 PF13405.6 EFC35821.1 - 0.076 13.0 0.1 1.8 8.7 0.0 3.3 3 0 0 3 3 3 0 EF-hand domain EF-hand_5 PF13202.6 EFC35821.1 - 0.18 11.3 1.1 0.47 10.0 0.1 2.2 2 0 0 2 2 2 0 EF hand AA_kinase PF00696.28 EFC35822.1 - 2e-18 66.9 0.1 5.6e-18 65.4 0.1 1.6 1 1 0 1 1 1 1 Amino acid kinase family FOXP-CC PF16159.5 EFC35823.1 - 0.068 13.8 4.9 2.8 8.6 0.5 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain zf_ZIC PF18366.1 EFC35823.1 - 0.15 12.2 8.4 0.61 10.2 7.0 2.6 1 1 1 2 2 2 0 Zic proteins zinc finger domain zf-C2H2 PF00096.26 EFC35823.1 - 4.7 7.9 16.1 4.5 7.9 4.0 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type Copine PF07002.16 EFC35824.1 - 1.6e-50 171.6 0.1 6.9e-50 169.5 0.1 2.0 1 1 0 1 1 1 1 Copine WH1 PF00568.23 EFC35824.1 - 2.8e-15 56.2 0.1 5.1e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 EFC35824.1 - 2.9e-11 43.6 0.0 7.7e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain vWA-TerF-like PF10138.9 EFC35824.1 - 0.0039 17.3 0.0 0.0068 16.5 0.0 1.5 1 1 0 1 1 1 1 vWA found in TerF C terminus SOG2 PF10428.9 EFC35824.1 - 0.26 10.5 9.4 0.37 9.9 9.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Pneumo_att_G PF05539.11 EFC35824.1 - 5.1 6.6 14.2 8.1 5.9 14.2 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SPX PF03105.19 EFC35824.1 - 8.8 6.1 10.9 14 5.5 10.9 1.2 1 0 0 1 1 1 0 SPX domain Rootletin PF15035.6 EFC35825.1 - 9.6e-05 22.5 7.7 9.6e-05 22.5 7.7 1.5 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion COG2 PF06148.11 EFC35825.1 - 0.00031 20.8 3.5 0.2 11.7 0.9 3.1 2 1 1 3 3 3 2 COG (conserved oligomeric Golgi) complex component, COG2 TPR_MLP1_2 PF07926.12 EFC35825.1 - 0.019 15.0 1.5 0.019 15.0 1.5 2.8 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein CortBP2 PF09727.9 EFC35825.1 - 0.062 13.2 10.9 0.068 13.1 10.0 1.6 1 1 0 1 1 1 0 Cortactin-binding protein-2 Carbam_trans_N PF02543.15 EFC35825.1 - 0.097 12.3 0.3 0.12 12.0 0.3 1.3 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus PKcGMP_CC PF16808.5 EFC35825.1 - 0.6 10.0 4.1 1.8 8.5 0.1 3.5 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4200 PF13863.6 EFC35825.1 - 2.4 8.6 14.0 2.2e+02 2.2 12.4 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Lzipper-MIP1 PF14389.6 EFC35825.1 - 2.6 8.4 11.5 7.6 6.9 1.3 4.1 2 2 1 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Fib_alpha PF08702.10 EFC35825.1 - 8.1 6.6 12.3 1.3 9.2 4.6 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family NicO PF03824.16 EFC35826.1 - 0.066 12.5 1.0 0.088 12.1 1.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein Response_reg PF00072.24 EFC35827.1 - 8.8e-18 64.5 0.4 1.6e-17 63.6 0.1 1.7 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFC35827.1 - 3.5e-07 30.2 0.0 3.1e-05 23.9 0.1 2.7 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain partial_CstF PF15861.5 EFC35827.1 - 0.12 12.2 1.2 3.9 7.4 0.0 3.0 3 0 0 3 3 3 0 Partial cleavage stimulation factor domain DUF4588 PF15251.6 EFC35827.1 - 0.2 11.4 5.7 0.24 11.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4588) ubiquitin PF00240.23 EFC35828.1 - 7.4e-63 208.2 5.9 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC35828.1 - 2.9e-30 103.9 7.5 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC35828.1 - 5.5e-09 36.4 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC35828.1 - 1.3e-08 34.6 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC35828.1 - 1.4e-08 34.8 0.4 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC35828.1 - 5.8e-07 29.8 1.6 0.025 14.9 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC35828.1 - 1.2e-06 29.0 0.1 0.015 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC35828.1 - 9e-05 22.4 6.5 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain Coagulin PF02035.15 EFC35828.1 - 0.043 13.7 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC35828.1 - 0.05 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC35828.1 - 0.072 13.5 1.0 0.84 10.0 0.2 2.5 2 1 0 3 3 3 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC35828.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC35828.1 - 0.14 12.3 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC35828.1 - 0.22 11.7 1.5 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain CHZ PF09649.10 EFC35829.1 - 1.3e-06 27.8 0.1 4.8e-05 22.7 0.1 2.3 2 0 0 2 2 2 2 Histone chaperone domain CHZ Pkinase_Tyr PF07714.17 EFC35830.1 - 8.3e-06 25.3 0.2 1e-05 25.0 0.2 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC35830.1 - 0.0037 16.7 0.0 0.0054 16.1 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain LRR_4 PF12799.7 EFC35831.1 - 8.7e-18 64.1 11.6 4.9e-09 36.3 0.3 4.0 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC35831.1 - 1.4e-13 50.4 5.3 1.7e-05 24.5 1.3 3.6 3 1 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 EFC35831.1 - 1.5e-13 50.6 0.1 1.3e-06 28.0 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFC35831.1 - 0.2 12.3 9.2 1.1e+02 4.0 0.0 5.0 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC35831.1 - 0.42 10.8 4.9 29 5.0 0.0 4.1 4 1 0 4 4 4 0 Leucine Rich repeat MFS_1 PF07690.16 EFC35832.1 - 7e-32 110.7 33.5 1.1e-23 83.8 15.3 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC35832.1 - 1.2e-09 37.6 4.5 1.2e-09 37.6 4.5 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.13 EFC35832.1 - 4.5e-05 22.0 0.8 0.00012 20.7 0.8 1.7 1 0 0 1 1 1 1 Transmembrane secretion effector DUF4094 PF13334.6 EFC35832.1 - 0.025 15.0 0.2 0.091 13.2 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF2371 PF10177.9 EFC35832.1 - 0.07 13.3 0.9 0.67 10.1 0.8 2.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) Pyrophosphatase PF00719.19 EFC35833.1 - 1.2e-44 151.9 1.6 1.5e-44 151.7 1.6 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase APC_u13 PF16634.5 EFC35834.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr and SAMP Ribosomal_L27A PF00828.19 EFC35835.1 - 9e-20 71.6 0.2 1.2e-19 71.2 0.2 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A EFG_C PF00679.24 EFC35836.1 - 3e-22 78.5 0.0 1.2e-21 76.5 0.0 2.0 2 1 1 3 3 3 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFC35836.1 - 8.7e-21 73.9 0.0 1.2e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor G, domain IV SIR2 PF02146.17 EFC35837.1 - 2.2e-47 161.3 0.0 2.6e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Sir2 family FYVE_2 PF02318.16 EFC35837.1 - 0.083 13.1 2.2 0.26 11.5 2.2 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger zinc_ribbon_4 PF13717.6 EFC35837.1 - 0.42 10.6 2.9 2.7 8.0 2.9 2.2 1 1 0 1 1 1 0 zinc-ribbon domain EF-hand_7 PF13499.6 EFC35838.1 - 3.8e-23 81.7 9.2 9.9e-12 45.1 1.6 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC35838.1 - 8.7e-23 78.1 4.3 3.6e-05 23.0 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EFC35838.1 - 2.3e-20 70.7 3.3 0.00024 20.8 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFC35838.1 - 9.6e-17 60.6 4.9 1.3e-05 24.9 0.0 3.5 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EFC35838.1 - 1.5e-15 55.8 1.7 0.0011 18.3 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.6 EFC35838.1 - 1.9e-07 30.8 1.2 0.00019 21.3 0.0 3.4 3 1 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EFC35838.1 - 0.004 17.5 2.2 3.8 7.9 0.5 3.1 2 2 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC35838.1 - 0.026 14.5 1.9 0.17 11.9 0.5 2.3 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand MecA_N PF05223.11 EFC35838.1 - 0.034 14.4 1.1 0.067 13.5 0.1 1.9 2 1 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain IFN-gamma PF00714.17 EFC35838.1 - 0.08 12.8 2.8 0.34 10.8 0.1 2.2 2 0 0 2 2 2 0 Interferon gamma adh_short PF00106.25 EFC35840.1 - 1.8e-51 174.4 0.7 2.3e-51 174.1 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC35840.1 - 2.6e-37 128.6 0.4 3.3e-37 128.3 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC35840.1 - 4e-11 43.1 0.2 5.6e-11 42.7 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC35840.1 - 2.9e-05 23.6 0.2 4.3e-05 23.1 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC35840.1 - 0.00073 18.8 0.7 0.00097 18.4 0.7 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFC35840.1 - 0.022 14.6 0.3 0.04 13.8 0.3 1.5 1 1 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFC35840.1 - 0.029 13.8 0.1 0.054 12.9 0.1 1.6 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase PRiA4_ORF3 PF07929.11 EFC35841.1 - 6.6e-18 65.0 0.0 6.6e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 Plasmid pRiA4b ORF-3-like protein YL1 PF05764.13 EFC35841.1 - 0.12 12.4 15.5 0.24 11.5 15.5 1.5 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 EFC35841.1 - 0.34 9.1 16.2 0.48 8.6 16.2 1.2 1 0 0 1 1 1 0 Nop14-like family CCG PF02754.16 EFC35841.1 - 0.37 11.0 2.0 0.43 10.8 0.1 2.0 2 1 1 3 3 3 0 Cysteine-rich domain TFIIF_alpha PF05793.12 EFC35841.1 - 1.5 7.3 29.9 2.6 6.5 29.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SGT1 PF07093.11 EFC35841.1 - 2 6.8 16.6 2.8 6.3 16.6 1.2 1 0 0 1 1 1 0 SGT1 protein Pox_RNA_Pol_19 PF05320.12 EFC35841.1 - 4.7 7.1 11.9 9.2 6.2 11.9 1.6 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit efThoc1 PF11957.8 EFC35843.1 - 0.002 16.9 3.8 0.0033 16.2 3.8 1.3 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Mistic PF11458.8 EFC35843.1 - 0.041 13.9 1.5 1.5 8.8 0.1 3.0 3 0 0 3 3 3 0 Membrane-integrating protein Mistic FANCI_S2 PF14676.6 EFC35843.1 - 0.11 12.7 2.3 6.2 7.1 0.3 2.9 1 1 0 2 2 2 0 FANCI solenoid 2 T3SchapCesA PF11439.8 EFC35843.1 - 0.13 12.4 2.5 10 6.4 0.1 3.3 3 0 0 3 3 3 0 Type III secretion system filament chaperone CesA Glutaredoxin PF00462.24 EFC35843.1 - 0.18 12.0 0.9 0.52 10.6 0.9 1.7 1 0 0 1 1 1 0 Glutaredoxin EGF_2 PF07974.13 EFC35844.1 - 2.9e-16 59.5 129.8 4.2e-06 27.0 9.8 9.8 9 0 0 9 9 9 6 EGF-like domain NHL PF01436.21 EFC35844.1 - 1.2e-08 34.5 3.1 0.00019 21.3 0.0 5.4 6 0 0 6 6 6 2 NHL repeat EGF PF00008.27 EFC35844.1 - 4.7e-06 26.8 95.8 0.0055 17.0 7.9 9.2 9 0 0 9 9 9 5 EGF-like domain SGL PF08450.12 EFC35844.1 - 0.0006 19.5 0.3 0.0018 17.9 0.2 1.8 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 EFC35844.1 - 0.0028 18.2 8.6 0.0028 18.2 8.6 11.1 11 0 0 11 11 11 4 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFC35844.1 - 0.0049 16.9 3.6 0.0049 16.9 3.6 8.0 9 0 0 9 9 9 1 Tenascin EGF domain RVP_2 PF08284.11 EFC35845.1 - 0.12 12.1 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Ras PF00071.22 EFC35846.1 - 3.9e-40 137.1 0.0 4.3e-40 137.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC35846.1 - 2e-22 79.6 0.0 2.3e-22 79.5 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC35846.1 - 2.4e-07 30.3 0.0 2.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EFC35847.1 - 2.6e-82 276.2 0.3 3e-82 276.0 0.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EFC35847.1 - 0.02 15.4 0.6 0.087 13.4 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC35847.1 - 0.061 13.6 0.1 0.23 11.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFC35847.1 - 0.076 12.5 0.0 0.9 9.0 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region CLP1_P PF16575.5 EFC35847.1 - 0.076 12.8 0.0 1 9.1 0.0 2.6 3 1 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop gpD PF02925.16 EFC35847.1 - 0.086 12.8 0.0 0.44 10.5 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage scaffolding protein D AAA_29 PF13555.6 EFC35847.1 - 0.09 12.5 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP-grasp_2 PF08442.10 EFC35848.1 - 6e-70 234.9 0.1 7.8e-70 234.5 0.1 1.1 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 EFC35848.1 - 3.7e-10 39.7 0.1 5.5e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFC35848.1 - 0.042 13.6 0.0 0.18 11.5 0.0 1.9 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Endonuc-MspI PF09208.10 EFC35848.1 - 0.053 12.9 0.1 0.45 9.9 0.0 2.2 2 0 0 2 2 2 0 Restriction endonuclease MspI Ligase_CoA PF00549.19 EFC35848.1 - 0.088 12.6 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 CoA-ligase NHL PF01436.21 EFC35849.1 - 4.6e-32 108.4 19.0 9.1e-09 34.9 0.6 7.4 8 0 0 8 8 8 4 NHL repeat DUF5128 PF17170.4 EFC35849.1 - 1.5e-08 34.2 7.7 0.0038 16.4 1.5 3.6 2 1 1 3 3 3 3 6-bladed beta-propeller SGL PF08450.12 EFC35849.1 - 9.2e-08 32.0 0.6 0.006 16.2 0.0 4.5 2 1 2 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC35849.1 - 2.7e-05 24.3 0.0 0.02 14.8 0.0 3.1 1 1 1 2 2 2 2 Esterase-like activity of phytase DUF4934 PF16288.5 EFC35849.1 - 0.00041 20.2 5.6 1.3 9.0 0.1 4.1 3 1 1 4 4 4 3 Domain of unknown function (DUF4934) PQQ_3 PF13570.6 EFC35849.1 - 0.014 15.8 0.3 1.4 9.5 0.0 3.0 3 0 0 3 3 3 0 PQQ-like domain NUMOD1 PF07453.13 EFC35849.1 - 0.02 15.1 0.0 7.6 6.9 0.0 3.3 3 0 0 3 3 3 0 NUMOD1 domain PQQ PF01011.21 EFC35849.1 - 0.039 13.9 0.0 2 8.5 0.0 3.1 3 0 0 3 3 3 0 PQQ enzyme repeat zf-SAP30 PF13866.6 EFC35849.1 - 8.5 6.6 8.8 41 4.4 0.3 4.1 4 0 0 4 4 4 0 SAP30 zinc-finger cEGF PF12662.7 EFC35851.1 - 4.5 7.3 10.9 24 5.0 3.7 3.3 3 0 0 3 3 3 0 Complement Clr-like EGF-like adh_short PF00106.25 EFC35852.1 - 5.9e-16 58.5 0.0 2.6e-14 53.2 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC35852.1 - 1.6e-11 44.2 0.0 2.9e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC35852.1 - 3.5e-05 23.8 0.0 0.00012 22.1 0.0 1.7 1 1 0 2 2 2 1 KR domain PAE PF03283.13 EFC35852.1 - 0.0015 17.7 0.0 0.0022 17.2 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase NHL PF01436.21 EFC35853.1 - 1.1e-18 66.2 2.9 6.3e-05 22.8 0.0 4.8 4 1 0 4 4 4 4 NHL repeat IreB PF06135.12 EFC35853.1 - 0.00024 21.2 0.5 4.1 7.7 0.0 3.6 4 0 0 4 4 4 2 IreB regulatory phosphoprotein Linker_histone PF00538.19 EFC35853.1 - 0.0035 17.7 0.1 28 5.1 0.0 3.8 4 0 0 4 4 4 0 linker histone H1 and H5 family TGT_C2 PF14810.6 EFC35853.1 - 0.011 15.8 0.0 49 4.1 0.0 3.3 3 0 0 3 3 3 0 Patch-forming domain C2 of tRNA-guanine transglycosylase E2_bind PF08825.10 EFC35853.1 - 0.019 15.1 0.0 6 7.1 0.0 3.3 4 0 0 4 4 4 0 E2 binding domain Ribosomal_S21 PF01165.20 EFC35853.1 - 0.2 11.4 2.3 28 4.5 0.1 3.2 3 0 0 3 3 3 0 Ribosomal protein S21 MHC_I_3 PF16497.5 EFC35853.1 - 0.22 11.0 0.0 5.1 6.5 0.0 2.1 2 0 0 2 2 2 0 MHC-I family domain DUF1939 PF09154.10 EFC35853.1 - 0.53 10.5 5.5 34 4.7 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1939) DUF4115 PF13464.6 EFC35854.1 - 0.0094 16.1 0.7 1.1 9.5 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4115) Laminin_I PF06008.14 EFC35854.1 - 0.098 12.3 14.3 0.13 11.9 14.3 1.1 1 0 0 1 1 1 0 Laminin Domain I TM2 PF05154.16 EFC35854.1 - 0.34 11.3 1.9 0.53 10.6 1.9 1.3 1 0 0 1 1 1 0 TM2 domain LMBR1 PF04791.16 EFC35854.1 - 6.2 5.6 7.9 8.4 5.2 7.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PHM7_cyt PF14703.6 EFC35857.1 - 1.7e-10 41.4 0.5 3.2e-09 37.3 0.2 2.4 2 1 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 EFC35857.1 - 8.1e-07 28.6 20.7 8.1e-07 28.6 20.7 2.7 2 1 1 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate Anoctamin PF04547.12 EFC35857.1 - 7.4e-05 21.8 6.9 7.4e-05 21.8 6.9 3.5 3 2 1 4 4 4 1 Calcium-activated chloride channel RRM_1 PF00076.22 EFC35857.1 - 0.14 12.0 0.1 32 4.5 0.0 2.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Stevor PF17410.2 EFC35857.1 - 4.7 6.7 9.5 0.34 10.4 1.8 2.4 2 1 0 2 2 2 0 Subtelomeric Variable Open Reading frame zf-CHY PF05495.12 EFC35858.1 - 9.1e-12 45.3 12.7 1.5e-11 44.6 12.7 1.3 1 0 0 1 1 1 1 CHY zinc finger DUF1768 PF08719.11 EFC35859.1 - 6.8e-48 162.9 0.7 7.5e-48 162.8 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) RGS PF00615.19 EFC35860.1 - 1.3e-08 35.1 2.7 3.1e-08 33.9 2.7 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC35860.1 - 0.00037 20.3 0.2 0.00081 19.1 0.2 1.6 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain Holin_BhlA PF10960.8 EFC35860.1 - 0.079 12.9 0.2 1.1 9.3 0.0 2.8 2 0 0 2 2 2 0 BhlA holin family JHD PF17811.1 EFC35860.1 - 0.092 13.3 5.6 0.16 12.6 1.7 2.7 2 0 0 2 2 2 0 Jumonji helical domain RCC1_2 PF13540.6 EFC35860.1 - 0.12 12.3 0.6 1.3 8.9 0.1 2.6 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat LRR_6 PF13516.6 EFC35861.1 - 3.8e-35 116.9 10.1 1.1e-05 25.1 0.0 8.7 9 0 0 9 9 9 6 Leucine Rich repeat LRR_8 PF13855.6 EFC35861.1 - 4.9e-21 74.3 0.7 8.2e-08 31.9 0.0 4.1 3 1 1 4 4 4 3 Leucine rich repeat ABC_membrane PF00664.23 EFC35861.1 - 7.4e-20 71.7 9.7 1.4e-19 70.8 9.7 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC35861.1 - 6.3e-19 68.8 0.0 1.5e-18 67.6 0.0 1.7 1 0 0 1 1 1 1 ABC transporter LRR_4 PF12799.7 EFC35861.1 - 1.1e-16 60.6 5.7 0.0015 18.9 0.0 5.5 4 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC35861.1 - 9.5e-08 31.6 0.0 9.6 7.2 0.0 7.4 8 0 0 8 8 7 1 Leucine Rich Repeat RsgA_GTPase PF03193.16 EFC35861.1 - 0.0001 22.3 0.0 0.00019 21.4 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC35861.1 - 0.0045 16.7 0.1 0.011 15.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 EFC35861.1 - 0.012 15.6 0.0 0.038 14.0 0.0 1.8 1 0 0 1 1 1 0 Dynamin family SMC_N PF02463.19 EFC35861.1 - 0.014 14.8 1.2 0.36 10.2 1.2 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFC35861.1 - 0.047 13.8 0.4 0.13 12.4 0.4 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC35861.1 - 0.27 11.5 1.2 0.83 9.9 0.3 2.0 2 0 0 2 2 2 0 AAA domain F-box PF00646.33 EFC35862.1 - 0.0029 17.4 0.1 0.0062 16.4 0.1 1.4 1 0 0 1 1 1 1 F-box domain G-alpha PF00503.20 EFC35863.1 - 2e-07 30.5 2.8 1.9e-05 24.0 0.9 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Orthopox_B11R PF07033.11 EFC35863.1 - 0.015 15.1 2.0 0.037 13.8 2.0 1.6 1 0 0 1 1 1 0 Orthopoxvirus B11R protein Moulting_cycle PF04870.16 EFC35865.1 - 0.038 13.3 9.5 0.045 13.0 9.5 1.1 1 0 0 1 1 1 0 Moulting cycle TetR_C_19 PF17924.1 EFC35865.1 - 0.04 14.5 3.6 0.31 11.6 3.4 2.1 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TFIIS_M PF07500.14 EFC35865.1 - 0.042 14.3 6.1 0.054 14.0 5.4 1.6 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain Gti1_Pac2 PF09729.9 EFC35865.1 - 0.097 12.8 5.5 0.12 12.5 5.5 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family RNA_pol_3_Rpc31 PF11705.8 EFC35865.1 - 0.28 11.4 10.1 0.31 11.3 10.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PPL5 PF18168.1 EFC35865.1 - 0.32 10.3 6.9 0.39 10.0 6.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 UPF0767 PF15990.5 EFC35865.1 - 0.63 10.2 2.8 1.3 9.2 2.8 1.6 1 0 0 1 1 1 0 UPF0767 family Presenilin PF01080.17 EFC35865.1 - 2.2 7.0 5.4 2.6 6.7 5.4 1.0 1 0 0 1 1 1 0 Presenilin CPDase PF07823.11 EFC35866.1 - 0.013 15.2 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein PID_2 PF14719.6 EFC35866.1 - 0.11 12.4 0.5 0.17 11.8 0.5 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Pre-PUA PF17832.1 EFC35867.1 - 0.1 13.3 0.3 0.35 11.6 0.2 1.8 2 0 0 2 2 2 0 Pre-PUA-like domain EGF_2 PF07974.13 EFC35870.1 - 8.7e-06 26.0 30.7 0.0037 17.6 11.5 2.7 2 0 0 2 2 2 2 EGF-like domain ADH_zinc_N_2 PF13602.6 EFC35871.1 - 7e-08 33.6 0.1 8.1e-07 30.2 0.1 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC35871.1 - 3.4e-06 27.0 0.0 7.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NHL PF01436.21 EFC35872.1 - 2.2e-26 90.5 11.5 6.7e-06 25.9 0.1 6.5 6 2 0 6 6 6 5 NHL repeat Linker_histone PF00538.19 EFC35872.1 - 9.1e-06 25.9 1.9 3.5 8.0 0.0 5.0 5 0 0 5 5 5 1 linker histone H1 and H5 family B2-adapt-app_C PF09066.10 EFC35872.1 - 0.0069 16.5 1.2 2.6 8.2 0.1 3.8 4 1 1 5 5 5 1 Beta2-adaptin appendage, C-terminal sub-domain ComGF PF15980.5 EFC35872.1 - 0.0072 16.7 0.2 29 5.1 0.0 4.3 5 0 0 5 5 5 0 Putative Competence protein ComGF HP1451_C PF18472.1 EFC35872.1 - 0.014 15.3 0.2 3.2 7.8 0.0 3.6 4 0 0 4 4 4 0 HP1451 C-terminal domain UNC-93 PF05978.16 EFC35872.1 - 0.028 14.1 0.3 0.053 13.2 0.3 1.5 1 0 0 1 1 1 0 Ion channel regulatory protein UNC-93 Plasmo_rep PF12135.8 EFC35872.1 - 0.05 13.2 28.7 1.3 8.7 0.4 6.5 8 1 0 8 8 8 0 Plasmodium repeat family Peptidase_A3 PF02160.15 EFC35872.1 - 0.19 11.2 0.8 42 3.5 0.0 3.8 5 0 0 5 5 5 0 Cauliflower mosaic virus peptidase (A3) DUF4551 PF15087.6 EFC35872.1 - 0.3 9.9 0.4 12 4.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4551) BcrAD_BadFG PF01869.20 EFC35872.1 - 0.85 9.1 6.6 5.5 6.4 0.1 3.7 2 1 1 4 4 4 0 BadF/BadG/BcrA/BcrD ATPase family DPPIV_N PF00930.21 EFC35872.1 - 0.87 8.3 4.0 0.69 8.6 0.3 2.5 3 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region TRL PF13146.6 EFC35872.1 - 3.2 8.1 8.6 30 5.0 0.1 3.9 5 0 0 5 5 5 0 TRL-like protein family PilN PF05137.13 EFC35872.1 - 3.9 7.7 10.0 63 3.8 0.0 4.8 5 0 0 5 5 5 0 Fimbrial assembly protein (PilN) TAL_effector PF03377.13 EFC35872.1 - 5.7 7.3 9.3 1.9e+02 2.5 0.1 4.9 5 0 0 5 5 5 0 TAL effector repeat Ank_3 PF13606.6 EFC35874.1 - 0.0017 18.7 0.0 0.0082 16.6 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EFC35874.1 - 0.0029 18.2 0.1 0.0035 17.9 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Transposase_21 PF02992.14 EFC35875.1 - 0.00078 18.7 0.0 0.0035 16.6 0.0 2.1 2 0 0 2 2 2 1 Transposase family tnp2 GerD PF17898.1 EFC35876.1 - 0.012 15.6 4.4 0.022 14.7 4.4 1.5 1 0 0 1 1 1 0 Spore germination GerD central core domain GEMIN8 PF15348.6 EFC35876.1 - 0.062 13.6 8.3 0.096 13.0 8.3 1.3 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 N6_N4_Mtase PF01555.18 EFC35877.1 - 1.7e-08 34.4 2.7 1.2e-07 31.7 0.0 3.0 2 1 0 2 2 2 1 DNA methylase PH_10 PF15411.6 EFC35877.1 - 9.9 6.4 11.8 1.4 9.2 3.3 3.0 3 0 0 3 3 3 0 Pleckstrin homology domain Zn_clus PF00172.18 EFC35878.1 - 2.5e-07 30.7 9.0 4.8e-07 29.8 9.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Prot_inhib_II PF02428.15 EFC35878.1 - 0.48 10.9 5.2 0.16 12.4 1.5 2.1 1 1 1 2 2 2 0 Potato type II proteinase inhibitor family LRR_6 PF13516.6 EFC35879.1 - 6.2e-31 103.8 0.6 7.6e-05 22.5 0.0 7.5 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.7 EFC35879.1 - 1.3e-18 66.8 10.8 3.1e-05 24.3 0.0 4.8 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC35879.1 - 3.1e-18 65.3 1.8 8.3e-06 25.5 0.0 4.2 4 0 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC35879.1 - 6.2e-10 38.2 0.1 10 7.1 0.0 7.6 8 0 0 8 8 8 1 Leucine Rich Repeat DUF4347 PF14252.6 EFC35879.1 - 0.0046 16.8 0.1 25 4.7 0.0 4.3 1 1 3 5 5 5 0 Domain of unknown function (DUF4347) Dynein_heavy PF03028.15 EFC35879.1 - 0.027 14.5 0.1 0.065 13.3 0.1 1.6 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain DUF2097 PF09870.9 EFC35879.1 - 0.091 13.0 3.7 5.9 7.2 0.0 3.9 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2097) ApoB100_C PF12491.8 EFC35879.1 - 0.16 12.0 12.1 0.61 10.1 0.1 5.7 4 1 4 8 8 8 0 Apolipoprotein B100 C terminal Met_10 PF02475.16 EFC35881.1 - 0.0053 16.5 0.1 0.0091 15.8 0.1 1.5 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 EFC35881.1 - 0.17 11.2 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Acetyltransf_1 PF00583.25 EFC35882.1 - 0.0002 21.6 0.0 0.00027 21.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFC35882.1 - 0.042 13.9 0.2 0.14 12.2 0.1 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC35882.1 - 0.049 13.6 0.4 0.12 12.3 0.4 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Voldacs PF03517.13 EFC35883.1 - 2.3e-19 69.9 2.7 3.6e-19 69.3 2.7 1.3 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Ribosomal_L18_c PF14204.6 EFC35883.1 - 0.15 13.0 1.9 0.46 11.4 1.1 2.1 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region SR-25 PF10500.9 EFC35884.1 - 0.18 11.4 11.2 0.31 10.6 11.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PQQ_3 PF13570.6 EFC35885.1 - 0.064 13.8 7.8 5.8 7.5 1.4 5.0 6 0 0 6 6 6 0 PQQ-like domain EGF_2 PF07974.13 EFC35885.1 - 1.3 9.5 17.9 0.39 11.1 6.3 2.9 2 1 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 EFC35886.1 - 0.00049 20.4 6.0 0.00049 20.4 6.0 8.6 4 3 1 5 5 5 1 EGF-like domain EGF PF00008.27 EFC35886.1 - 0.043 14.1 3.9 0.043 14.1 3.9 8.5 9 2 1 10 10 10 0 EGF-like domain REJ PF02010.15 EFC35887.1 - 3.7e-34 118.3 3.5 3.7e-34 118.3 3.5 3.5 3 1 1 4 4 4 2 REJ domain TMEM154 PF15102.6 EFC35887.1 - 9.8e-05 22.3 0.6 9.8e-05 22.3 0.6 2.3 2 0 0 2 2 2 1 TMEM154 protein family Laminin_EGF PF00053.24 EFC35887.1 - 0.00037 20.6 16.0 0.00037 20.6 16.0 11.8 4 2 7 11 11 11 2 Laminin EGF domain DAG1 PF05454.11 EFC35887.1 - 1.8 7.9 12.1 0.16 11.3 6.4 2.2 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) NHL PF01436.21 EFC35888.1 - 4.2e-31 105.4 7.2 8.2e-07 28.8 0.0 6.0 6 0 0 6 6 6 5 NHL repeat DUF5128 PF17170.4 EFC35888.1 - 2.2e-14 53.3 8.1 7.2e-06 25.4 0.5 3.7 3 1 1 4 4 4 3 6-bladed beta-propeller SGL PF08450.12 EFC35888.1 - 3.5e-10 39.9 0.9 1.9e-05 24.4 0.1 4.4 2 2 2 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EFC35888.1 - 6.7e-05 22.8 7.7 0.0065 16.4 0.2 4.3 5 0 0 5 5 5 2 Beta-propeller repeat DUF4934 PF16288.5 EFC35888.1 - 0.0014 18.5 0.5 0.016 15.1 0.0 2.8 3 1 1 4 4 4 1 Domain of unknown function (DUF4934) Arylesterase PF01731.20 EFC35888.1 - 0.0027 17.9 0.9 5.4 7.3 0.0 4.4 5 0 0 5 5 5 1 Arylesterase Phytase-like PF13449.6 EFC35888.1 - 0.022 14.7 0.0 2.2 8.1 0.0 2.6 2 1 0 2 2 2 0 Esterase-like activity of phytase Pkinase_Tyr PF07714.17 EFC35890.1 - 1.1e-25 90.4 0.2 1.9e-25 89.6 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC35890.1 - 9.7e-21 74.3 0.6 9.7e-21 74.3 0.6 1.6 2 0 0 2 2 2 1 Protein kinase domain Chlam_PMP PF02415.17 EFC35890.1 - 3 8.5 49.2 0.99 10.0 0.1 8.4 9 0 0 9 9 9 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat FERM_M PF00373.18 EFC35891.1 - 0.073 13.5 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 FERM central domain DUF1381 PF07129.11 EFC35891.1 - 0.092 12.6 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1381) PLATZ PF04640.14 EFC35891.1 - 0.1 13.3 2.7 0.16 12.6 2.7 1.3 1 0 0 1 1 1 0 PLATZ transcription factor DUF668 PF05003.12 EFC35891.1 - 0.11 12.9 0.1 0.15 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF668) zinc_ribbon_6 PF14599.6 EFC35891.1 - 0.43 10.6 3.4 3.5 7.7 0.3 2.5 2 1 0 2 2 2 0 Zinc-ribbon Ntox50 PF15542.6 EFC35891.1 - 0.47 11.3 5.8 1.1 10.1 5.8 1.6 1 1 0 1 1 1 0 Bacterial toxin 50 DUF4218 PF13960.6 EFC35892.1 - 0.035 13.7 0.0 0.077 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4218) EZH2_N PF18601.1 EFC35892.1 - 0.074 13.4 0.3 0.18 12.2 0.3 1.6 1 0 0 1 1 1 0 EZH2 N-terminal domain DUF4164 PF13747.6 EFC35893.1 - 0.005 17.1 2.0 0.01 16.1 2.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) Cep57_CLD_2 PF14197.6 EFC35893.1 - 0.019 15.1 3.3 0.039 14.0 3.3 1.5 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 YabA PF06156.13 EFC35893.1 - 7.1 7.3 8.5 0.93 10.2 2.9 2.2 2 0 0 2 2 2 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 EFC35893.1 - 9.1 6.5 13.0 0.4 10.9 5.3 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4116 PF13475.6 EFC35894.1 - 0 1138.0 63.1 2.6e-21 75.1 0.1 16.6 6 2 11 20 20 20 20 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC35894.1 - 1.2e-15 57.7 0.0 6.1e-15 55.3 0.0 2.2 1 1 1 2 2 2 1 Protein kinase domain AfsA PF03756.13 EFC35894.1 - 3.4e-14 53.0 0.0 5.6 7.0 0.0 9.8 2 2 12 14 14 14 3 A-factor biosynthesis hotdog domain 6PF2K PF01591.18 EFC35894.1 - 3.9e-09 36.1 36.8 0.44 9.8 0.9 10.3 1 1 10 11 11 11 6 6-phosphofructo-2-kinase Pkinase_Tyr PF07714.17 EFC35894.1 - 1.5e-05 24.4 0.0 5.6e-05 22.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase DUF4853 PF16145.5 EFC35894.1 - 0.00025 21.2 15.0 24 5.1 0.0 9.6 4 2 3 11 11 11 0 Domain of unknown function (DUF4853) Kinase-PolyVal PF18762.1 EFC35894.1 - 0.044 13.7 23.8 28 4.6 0.0 9.0 5 3 6 12 12 12 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins P_C10 PF14974.6 EFC35894.1 - 0.053 13.6 0.2 1.4e+02 2.6 0.0 4.9 3 1 0 3 3 3 0 Protein C10 DUF5551 PF17705.1 EFC35894.1 - 0.21 11.2 0.6 97 2.6 0.0 4.8 4 1 1 5 5 5 0 Family of unknown function (DUF5551) DUF2971 PF11185.8 EFC35894.1 - 0.52 11.5 16.1 2e+02 3.2 0.0 7.8 2 2 3 5 5 4 0 Protein of unknown function (DUF2971) AAA_18 PF13238.6 EFC35894.1 - 0.83 10.2 37.9 4.8 7.7 0.6 8.8 2 1 5 8 8 8 0 AAA domain CLTH PF10607.9 EFC35894.1 - 5.2 6.9 6.0 3.1e+02 1.2 0.0 4.9 2 2 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Trypsin PF00089.26 EFC35895.1 - 7.1e-28 97.9 0.2 8.2e-28 97.7 0.2 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC35895.1 - 0.00079 20.3 0.0 0.0012 19.8 0.0 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain Ndc1_Nup PF09531.10 EFC35896.1 - 1.1 7.9 4.0 1.4 7.5 4.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Paramyxo_C PF01692.18 EFC35896.1 - 2.8 7.3 8.1 6.6 6.1 7.8 1.7 2 0 0 2 2 2 0 Paramyxovirus non-structural protein C DUF3377 PF11857.8 EFC35897.1 - 0.18 11.7 1.5 0.32 10.9 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) NapE PF06796.11 EFC35897.1 - 3.2 7.3 5.5 6.7 6.3 5.5 1.5 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE Ras PF00071.22 EFC35898.1 - 3.4e-10 39.8 0.1 5.8e-10 39.0 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC35898.1 - 0.00095 19.4 0.0 0.0021 18.3 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC35898.1 - 0.092 12.3 0.1 0.23 11.0 0.1 1.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Tab2_like PF06485.11 EFC35899.1 - 0.019 14.5 0.0 0.024 14.1 0.0 1.1 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 Pkinase PF00069.25 EFC35900.1 - 2e-27 96.2 3.1 7.5e-27 94.3 3.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35900.1 - 1.8e-17 63.5 0.2 2.3e-17 63.1 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC35900.1 - 4.9e-05 22.3 0.1 7e-05 21.8 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF3791 PF12668.7 EFC35900.1 - 0.021 14.9 0.5 4.8 7.3 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) FA_desaturase PF00487.24 EFC35901.1 - 5e-10 39.6 10.6 8.6e-10 38.9 10.6 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Ank_2 PF12796.7 EFC35902.1 - 4.5e-17 62.4 0.1 1.1e-10 41.9 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC35902.1 - 1e-13 50.1 0.1 0.004 17.5 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFC35902.1 - 8.4e-13 48.6 0.3 0.0015 19.0 0.0 4.0 2 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC35902.1 - 1.9e-10 40.7 0.1 0.066 13.7 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFC35902.1 - 8.6e-10 38.7 0.1 0.0078 16.5 0.1 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) NHL PF01436.21 EFC35903.1 - 1.7e-19 68.8 4.3 0.0011 18.9 0.0 5.8 6 0 0 6 6 6 4 NHL repeat SGL PF08450.12 EFC35903.1 - 0.00028 20.5 0.3 2.9 7.4 0.0 4.0 2 2 2 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region ComGF PF15980.5 EFC35903.1 - 0.054 13.9 0.2 8.3 6.8 0.0 3.6 4 0 0 4 4 4 0 Putative Competence protein ComGF Phytase-like PF13449.6 EFC35903.1 - 0.068 13.1 0.0 40 4.0 0.0 3.8 3 1 1 4 4 4 0 Esterase-like activity of phytase DUF5050 PF16472.5 EFC35903.1 - 0.29 10.4 5.8 4.5 6.4 0.1 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5050) Plasmo_rep PF12135.8 EFC35903.1 - 4.1 7.0 7.9 3.6 7.2 0.4 3.6 3 0 0 3 3 3 0 Plasmodium repeat family PhoLip_ATPase_C PF16212.5 EFC35904.1 - 5.8e-84 281.7 26.7 6.7e-84 281.5 26.7 1.0 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal NHL PF01436.21 EFC35905.1 - 1.5e-17 62.7 0.0 0.00039 20.3 0.0 6.2 6 0 0 6 6 6 4 NHL repeat Phytase-like PF13449.6 EFC35905.1 - 0.0006 19.8 0.0 0.0028 17.7 0.0 2.0 2 1 1 3 3 3 1 Esterase-like activity of phytase SBBP PF06739.11 EFC35905.1 - 0.0011 18.9 1.2 7.9 6.6 0.1 4.6 3 0 0 3 3 3 2 Beta-propeller repeat NHL PF01436.21 EFC35906.1 - 7.1e-43 142.5 7.8 1.3e-06 28.1 0.0 6.9 6 0 0 6 6 6 6 NHL repeat Linker_histone PF00538.19 EFC35906.1 - 5.4e-11 42.7 0.4 4.6 7.7 0.0 6.6 6 0 0 6 6 6 2 linker histone H1 and H5 family BTB PF00651.31 EFC35906.1 - 2.6e-10 40.5 2.7 2.6e-10 40.5 0.3 2.3 3 0 0 3 3 3 1 BTB/POZ domain SGL PF08450.12 EFC35906.1 - 8.6e-08 32.1 0.0 1.1 8.8 0.0 4.5 3 2 1 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region DUF1236 PF06823.12 EFC35906.1 - 0.00029 20.6 3.1 89 3.1 0.0 6.5 7 0 0 7 7 7 0 Protein of unknown function (DUF1236) Plasmo_rep PF12135.8 EFC35906.1 - 0.00047 19.6 27.2 4.2 7.0 0.2 7.0 7 0 0 7 7 7 6 Plasmodium repeat family Coatomer_WDAD PF04053.14 EFC35906.1 - 0.00056 19.1 1.4 5.6 5.9 0.1 4.0 1 1 4 5 5 5 2 Coatomer WD associated region MJ1316 PF04457.12 EFC35906.1 - 0.001 19.8 5.1 2.5e+02 2.5 0.0 6.3 6 0 0 6 6 6 0 MJ1316 RNA cyclic group end recognition domain PCMT PF01135.19 EFC35906.1 - 0.15 11.8 0.9 5.9 6.6 0.0 3.6 3 1 1 4 4 4 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) adh_short PF00106.25 EFC35907.1 - 3.2e-32 111.6 0.0 1.4e-17 63.9 0.0 2.3 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC35907.1 - 1.4e-19 70.6 0.0 5.7e-11 42.4 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC35907.1 - 6.9e-09 35.9 0.0 2.7e-07 30.7 0.0 2.1 1 1 1 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 EFC35907.1 - 0.025 13.7 0.6 0.052 12.7 0.1 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Mito_carr PF00153.27 EFC35908.1 - 7.7e-64 211.7 3.5 3.8e-22 78.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Trp_Tyr_perm PF03222.13 EFC35909.1 - 0.0059 15.7 0.9 0.0059 15.7 0.9 1.4 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Suv3_N PF18114.1 EFC35909.1 - 0.24 11.5 4.4 2.6 8.2 0.2 2.4 2 0 0 2 2 2 0 Suv3 helical N-terminal domain Neurensin PF14927.6 EFC35910.1 - 0.016 14.9 0.4 8.8 6.0 0.0 3.0 2 1 1 3 3 3 0 Neurensin DUF4040 PF13244.6 EFC35910.1 - 0.037 14.2 1.8 0.12 12.6 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4040) DUF4131 PF13567.6 EFC35910.1 - 0.066 12.9 0.0 1.7 8.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF4083 PF13314.6 EFC35910.1 - 0.077 12.9 3.5 1.7 8.6 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) COPI_assoc PF08507.10 EFC35910.1 - 0.33 11.0 0.1 0.33 11.0 0.1 3.5 4 1 1 5 5 5 0 COPI associated protein DUF2721 PF11026.8 EFC35910.1 - 0.39 10.6 3.8 0.4 10.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) DUF3139 PF11337.8 EFC35910.1 - 4.9 7.9 8.7 5.7 7.7 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3139) NST1 PF13945.6 EFC35911.1 - 1.5e-15 57.8 8.7 1.5e-15 57.8 8.7 3.0 1 1 1 2 2 2 1 Salt tolerance down-regulator Syntaxin-18_N PF10496.9 EFC35911.1 - 1.5 9.2 11.5 0.1 12.8 3.1 2.9 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus TPT PF03151.16 EFC35912.1 - 2.3e-22 79.7 25.9 2.6e-22 79.5 25.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC35912.1 - 4.5e-08 33.3 30.5 1.6e-06 28.4 15.4 2.9 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFC35912.1 - 0.00029 20.1 31.0 0.00044 19.5 31.0 1.4 1 1 0 1 1 1 1 UAA transporter family Ly-6_related PF06579.12 EFC35912.1 - 0.018 15.2 0.4 0.12 12.6 0.2 2.1 1 1 1 2 2 2 0 Caenorhabditis elegans ly-6-related protein DUF1129 PF06570.11 EFC35912.1 - 1.3 8.4 6.8 1.9 8.0 5.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) PUNUT PF16913.5 EFC35912.1 - 7.7 5.6 26.8 26 3.9 26.8 2.3 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport Mito_carr PF00153.27 EFC35913.1 - 4.7e-14 52.1 2.6 0.0028 17.5 0.1 5.1 5 0 0 5 5 5 5 Mitochondrial carrier protein RNase_H PF00075.24 EFC35914.1 - 1.6e-11 44.6 0.1 4.1e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 RNase H YhfZ_C PF14503.6 EFC35917.1 - 0.079 12.5 0.0 0.14 11.7 0.0 1.5 1 1 0 1 1 1 0 YhfZ C-terminal domain DUF4680 PF15730.5 EFC35918.1 - 0.0052 17.1 2.4 0.007 16.7 2.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4680) Nop52 PF05997.12 EFC35918.1 - 0.14 12.0 4.0 0.081 12.7 1.7 1.7 1 1 1 2 2 2 0 Nucleolar protein,Nop52 Ndc1_Nup PF09531.10 EFC35918.1 - 0.24 10.0 5.4 0.27 9.9 5.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ATP11 PF06644.11 EFC35918.1 - 0.72 9.6 7.9 0.89 9.3 7.7 1.3 1 1 0 1 1 1 0 ATP11 protein Ribonuc_2-5A PF06479.12 EFC35919.1 - 0.049 13.8 0.7 11 6.2 0.1 3.0 3 0 0 3 3 3 0 Ribonuclease 2-5A Arm_vescicular PF18770.1 EFC35919.1 - 0.18 11.8 0.1 0.45 10.5 0.1 1.6 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor CelTOS PF18659.1 EFC35919.1 - 0.66 10.4 4.0 0.41 11.1 0.1 2.5 3 0 0 3 3 3 0 Cell-traversal protein for ookinetes and sporozoites Csm2_III-A PF03750.13 EFC35919.1 - 1.5 9.7 4.4 1.7 9.5 0.0 3.2 3 1 1 4 4 4 0 Csm2 Type III-A Symplekin_C PF12295.8 EFC35919.1 - 9.1 6.3 6.8 3 7.9 0.2 3.4 4 1 1 5 5 5 0 Symplekin tight junction protein C terminal Pkinase PF00069.25 EFC35920.1 - 3.7e-39 134.7 0.8 7e-39 133.8 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC35920.1 - 6.5e-26 91.2 0.0 9.4e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Cyclase PF04199.13 EFC35920.1 - 4.5e-11 43.2 0.0 9e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Putative cyclase Kdo PF06293.14 EFC35920.1 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Curto_V2 PF07325.11 EFC35921.1 - 0.0035 17.2 4.0 0.0046 16.8 4.0 1.1 1 0 0 1 1 1 1 Curtovirus V2 protein RNA_pol_3_Rpc31 PF11705.8 EFC35921.1 - 0.0068 16.7 11.4 0.0073 16.6 11.4 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Endonuc-BsobI PF09194.10 EFC35921.1 - 0.029 13.6 0.1 0.035 13.3 0.1 1.0 1 0 0 1 1 1 0 Restriction endonuclease BsobI tRNA_bind_2 PF13725.6 EFC35921.1 - 0.038 13.7 3.5 0.049 13.3 3.5 1.1 1 0 0 1 1 1 0 Possible tRNA binding domain MiaE_2 PF13794.6 EFC35921.1 - 0.042 13.5 0.2 0.059 13.1 0.2 1.3 1 0 0 1 1 1 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like DNA_pol_phi PF04931.13 EFC35921.1 - 2 6.4 13.8 2.1 6.4 13.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFC35921.1 - 2.4 7.4 9.8 2.6 7.3 9.8 1.1 1 0 0 1 1 1 0 NOA36 protein Alpha_adaptin_C PF02296.16 EFC35922.1 - 2.1e-22 79.4 0.0 2.6e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain B2-adapt-app_C PF09066.10 EFC35922.1 - 0.0015 18.6 0.4 0.017 15.2 0.4 2.0 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Coatomer_g_Cpla PF16381.5 EFC35922.1 - 0.0015 18.6 0.0 0.0023 18.1 0.0 1.2 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform ELMO_CED12 PF04727.13 EFC35923.1 - 6.9e-28 97.9 0.1 6.9e-28 97.9 0.1 2.0 2 0 0 2 2 2 1 ELMO/CED-12 family Daxx PF03344.15 EFC35923.1 - 0.059 13.4 0.2 0.059 13.4 0.2 2.2 2 0 0 2 2 2 0 Daxx N-terminal Rassf1C-interacting domain Guanylate_cyc PF00211.20 EFC35924.1 - 2.5e-53 180.4 0.0 4.2e-53 179.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC35924.1 - 1.8e-15 57.1 0.2 4e-15 55.9 0.2 1.6 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC35924.1 - 5.2e-07 29.7 0.0 9.5e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.12 EFC35924.1 - 0.014 15.7 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC35924.1 - 0.015 14.8 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 Heme NO binding associated FlgT_M PF16539.5 EFC35924.1 - 0.05 13.7 0.1 0.094 12.8 0.1 1.4 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain PAS_4 PF08448.10 EFC35924.1 - 0.093 13.0 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 PAS fold DUF4116 PF13475.6 EFC35925.1 - 1.9e-58 194.0 1.2 1.6e-20 72.6 0.1 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF4116) 6PF2K PF01591.18 EFC35925.1 - 0.00044 19.6 0.1 0.1 11.9 0.0 2.3 1 1 1 2 2 2 2 6-phosphofructo-2-kinase Rsbr_N PF08678.10 EFC35925.1 - 0.0031 17.6 0.0 8.5 6.5 0.0 3.0 1 1 2 3 3 3 1 Rsbr N terminal YafO_toxin PF13957.6 EFC35925.1 - 0.017 15.2 0.0 4.4 7.4 0.0 2.8 1 1 3 4 4 4 0 Toxin YafO, type II toxin-antitoxin system DUF5033 PF16436.5 EFC35925.1 - 0.025 14.6 0.5 29 4.6 0.0 3.3 1 1 1 3 3 3 0 Domain of unknown function (DUF5033) Sec7_N PF12783.7 EFC35925.1 - 0.06 13.2 0.0 0.22 11.4 0.0 1.8 1 1 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Peptidase_M10_C PF08548.11 EFC35925.1 - 0.06 13.2 0.2 1.6 8.6 0.0 2.1 1 1 1 2 2 2 0 Peptidase M10 serralysin C terminal DUF3929 PF13066.6 EFC35925.1 - 0.17 12.0 4.2 25 5.0 0.0 4.1 1 1 5 6 6 6 0 Protein of unknown function (DUF3929) TP1 PF02079.16 EFC35925.1 - 0.19 11.7 0.3 40 4.2 0.0 3.4 2 1 1 3 3 3 0 Nuclear transition protein 1 Vta1_C PF18097.1 EFC35925.1 - 0.28 10.9 3.1 48 3.8 0.0 4.0 4 0 0 4 4 4 0 Vta1 C-terminal domain EGF_2 PF07974.13 EFC35926.1 - 1.9e-05 24.9 20.1 0.00041 20.7 5.4 11.8 11 1 1 12 12 12 3 EGF-like domain RCC1_2 PF13540.6 EFC35926.1 - 0.0012 18.6 0.0 0.11 12.3 0.0 3.4 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Apis_Csd PF11671.8 EFC35927.1 - 0.013 15.5 2.3 0.013 15.5 2.3 3.1 3 1 0 3 3 3 0 Complementary sex determiner protein Eaf7 PF07904.13 EFC35927.1 - 0.17 12.3 2.8 0.96 9.9 1.3 2.5 2 0 0 2 2 2 0 Chromatin modification-related protein EAF7 Casc1_N PF15927.5 EFC35928.1 - 0.0037 17.0 1.0 0.0055 16.4 1.0 1.2 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus AT_hook PF02178.19 EFC35928.1 - 0.56 10.3 6.6 1.1 9.4 6.6 1.5 1 0 0 1 1 1 0 AT hook motif RWP-RK PF02042.15 EFC35929.1 - 7.5e-07 29.0 0.2 1.5e-06 28.1 0.2 1.5 1 0 0 1 1 1 1 RWP-RK domain Pinin_SDK_memA PF04696.13 EFC35929.1 - 0.21 11.6 2.3 0.39 10.8 1.9 1.6 1 1 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF1508 PF07411.12 EFC35930.1 - 0.04 13.8 0.9 0.071 13.0 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1508) Arm PF00514.23 EFC35931.1 - 6.4e-05 22.9 1.5 0.74 10.0 0.0 3.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat PBP_GOBP PF01395.22 EFC35931.1 - 0.016 15.4 0.3 0.038 14.2 0.3 1.6 1 0 0 1 1 1 0 PBP/GOBP family NTP_transf_7 PF07984.12 EFC35931.1 - 0.032 13.5 0.4 0.054 12.7 0.4 1.4 1 0 0 1 1 1 0 Nucleotidyltransferase UNC45-central PF11701.8 EFC35931.1 - 0.083 12.9 6.9 0.94 9.4 0.1 3.6 3 1 0 3 3 3 0 Myosin-binding striated muscle assembly central Inhibitor_I48 PF10467.9 EFC35931.1 - 0.091 12.6 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase inhibitor clitocypin DUF2626 PF11117.8 EFC35932.1 - 0.073 13.8 0.8 0.13 13.0 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2626) CYTH PF01928.21 EFC35933.1 - 0.043 13.8 0.1 0.071 13.0 0.1 1.4 1 0 0 1 1 1 0 CYTH domain 7TM_GPCR_Srv PF10323.9 EFC35935.1 - 0.043 13.2 1.1 0.063 12.6 1.1 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Peptidase_M20 PF01546.28 EFC35936.1 - 1.9e-30 106.1 0.6 3.5e-30 105.3 0.6 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC35936.1 - 5.2e-14 52.1 0.1 1.7e-13 50.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain SPA PF08616.10 EFC35937.1 - 2e-28 98.6 0.1 8.5e-28 96.6 0.1 2.2 1 0 0 1 1 1 1 Stabilization of polarity axis DENN PF02141.21 EFC35937.1 - 4.5e-07 30.0 1.5 4.5e-07 30.0 1.5 2.6 2 1 0 2 2 2 1 DENN (AEX-3) domain Afi1 PF07792.12 EFC35937.1 - 6e-06 26.8 0.0 6e-06 26.8 0.0 2.8 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking ubiquitin PF00240.23 EFC35937.1 - 0.00034 20.3 0.8 0.00092 18.9 0.2 2.1 2 0 0 2 2 2 1 Ubiquitin family UBA PF00627.31 EFC35937.1 - 0.002 18.0 0.0 0.0049 16.7 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain L_HMGIC_fpl PF10242.9 EFC35937.1 - 0.0082 16.4 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DGF-1_C PF11040.8 EFC35937.1 - 0.48 10.5 1.6 1.2 9.1 1.6 1.6 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DED PF01335.21 EFC35937.1 - 3.2 8.1 6.4 0.73 10.2 0.8 2.8 3 0 0 3 3 3 0 Death effector domain UPF0113_N PF17833.1 EFC35938.1 - 1.7e-26 92.5 2.5 2.6e-26 92.0 2.5 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EFC35938.1 - 2e-25 88.9 0.0 4e-25 87.9 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EFC35938.1 - 0.00076 19.4 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 PUA domain 2OG-FeII_Oxy_3 PF13640.6 EFC35940.1 - 4.9e-08 33.8 0.0 7.6e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EFC35940.1 - 0.067 13.9 0.1 0.18 12.5 0.1 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PAD PF03068.15 EFC35940.1 - 0.071 12.1 0.0 0.098 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) LRR_6 PF13516.6 EFC35941.1 - 8.7e-25 84.6 6.1 0.0014 18.5 0.1 8.4 8 0 0 8 8 8 4 Leucine Rich repeat LRR_8 PF13855.6 EFC35941.1 - 1.1e-14 53.9 8.3 2.1e-07 30.6 0.9 4.3 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC35941.1 - 2e-14 53.5 8.9 0.0033 17.8 1.0 5.2 2 2 2 4 4 4 3 Leucine Rich repeats (2 copies) FTH PF01827.27 EFC35941.1 - 0.00036 20.3 0.1 0.0028 17.5 0.0 2.2 1 1 1 2 2 2 1 FTH domain LRR_1 PF00560.33 EFC35941.1 - 0.0007 19.8 4.7 40 5.3 0.1 6.5 7 1 0 7 7 7 0 Leucine Rich Repeat F-box-like PF12937.7 EFC35941.1 - 0.00081 19.2 0.3 0.0014 18.4 0.3 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC35941.1 - 0.00098 18.9 0.8 0.0021 17.9 0.8 1.5 1 0 0 1 1 1 1 F-box domain Phage_CI_C PF16452.5 EFC35941.1 - 0.0032 17.7 0.2 1.6 9.0 0.1 3.4 1 1 3 4 4 4 1 Bacteriophage CI repressor C-terminal domain RecO_N_2 PF13114.6 EFC35941.1 - 0.02 14.6 0.8 0.82 9.4 0.0 3.2 3 1 1 4 4 4 0 RecO N terminal ApoB100_C PF12491.8 EFC35941.1 - 0.11 12.4 1.3 48 4.0 0.0 4.3 3 1 2 5 5 5 0 Apolipoprotein B100 C terminal PIN_12 PF16289.5 EFC35943.1 - 0.0047 17.4 2.3 0.0066 17.0 2.3 1.3 1 0 0 1 1 1 1 PIN domain Macoilin PF09726.9 EFC35944.1 - 0.23 10.0 3.9 0.24 9.9 3.9 1.1 1 0 0 1 1 1 0 Macoilin family NUDIX PF00293.28 EFC35945.1 - 2.8e-12 46.8 0.0 4.1e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Glyco_hydro_97 PF10566.9 EFC35945.1 - 0.023 14.0 0.2 0.037 13.3 0.2 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 NUDIX_2 PF13869.6 EFC35945.1 - 0.073 12.6 0.6 0.1 12.2 0.1 1.5 2 0 0 2 2 2 0 Nucleotide hydrolase BTB PF00651.31 EFC35947.1 - 6.2e-10 39.3 0.0 1.2e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain ThiF PF00899.21 EFC35948.1 - 1.9e-19 70.0 0.0 2.6e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family E1_FCCH PF16190.5 EFC35948.1 - 3.2e-05 24.0 0.4 0.00012 22.2 0.2 2.1 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain NAD_binding_7 PF13241.6 EFC35948.1 - 4.7e-05 23.8 0.0 7.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding TrkA_N PF02254.18 EFC35948.1 - 6.5e-05 23.2 0.0 0.00014 22.1 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 EFC35948.1 - 0.0014 18.7 0.1 0.0089 16.1 0.0 2.1 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase KR PF08659.10 EFC35948.1 - 0.021 14.8 0.1 0.028 14.4 0.1 1.3 1 1 0 1 1 1 0 KR domain VWA PF00092.28 EFC35949.1 - 2.4e-12 47.4 3.2 4.3e-12 46.6 3.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC35949.1 - 1.4e-09 38.5 0.7 9.6e-09 35.9 0.1 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC35949.1 - 2.2e-08 34.2 0.2 3.8e-08 33.4 0.2 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.9 EFC35949.1 - 4.2e-06 26.9 0.2 8.5e-06 25.9 0.2 1.6 1 0 0 1 1 1 1 VWA-like domain (DUF2201) VWA_CoxE PF05762.14 EFC35949.1 - 0.00026 20.4 0.1 0.00049 19.5 0.1 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein GyrI-like PF06445.15 EFC35951.1 - 0.0012 19.2 0.8 0.0017 18.7 0.8 1.4 1 1 0 1 1 1 1 GyrI-like small molecule binding domain DUF842 PF05811.13 EFC35952.1 - 1.7 8.3 4.6 6.1 6.6 0.0 3.0 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF842) NRDD PF13597.6 EFC35953.1 - 0.043 12.6 0.1 0.071 11.9 0.1 1.2 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase DDE_3 PF13358.6 EFC35954.1 - 0.12 12.2 0.6 0.17 11.6 0.1 1.5 2 0 0 2 2 2 0 DDE superfamily endonuclease Acetyltransf_2 PF00797.17 EFC35955.1 - 0.014 15.2 0.1 0.02 14.7 0.1 1.3 1 0 0 1 1 1 0 N-acetyltransferase Ribosomal_S30 PF04758.14 EFC35957.1 - 1.2e-07 31.8 0.1 1.2e-07 31.8 0.1 2.7 2 1 1 3 3 3 1 Ribosomal protein S30 LRR_6 PF13516.6 EFC35958.1 - 1.6e-09 37.0 7.8 0.00029 20.7 0.1 5.8 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 EFC35958.1 - 3.4e-09 36.8 13.7 0.16 12.5 3.5 5.8 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC35958.1 - 3.2e-06 26.8 10.6 0.073 12.8 0.0 4.7 3 1 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFC35958.1 - 0.14 12.8 11.1 11 7.1 0.0 6.8 9 1 0 9 9 9 0 Leucine Rich Repeat PheRS_DBD2 PF18554.1 EFC35960.1 - 0.43 10.6 2.2 4.3 7.4 1.4 2.6 2 0 0 2 2 2 0 PheRS DNA binding domain 2 Sel1 PF08238.12 EFC35961.1 - 2.8e-23 81.8 1.4 6.7e-11 42.5 0.2 3.3 3 0 0 3 3 3 2 Sel1 repeat TPR_1 PF00515.28 EFC35961.1 - 1.1 9.2 4.3 1.6 8.7 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EFC35961.1 - 1.9 8.6 4.8 1.2 9.2 0.2 2.5 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain PRP1_N PF06424.12 EFC35962.1 - 0.063 13.7 2.5 0.094 13.1 2.5 1.3 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Lipoprot_C PF08794.10 EFC35962.1 - 0.072 13.1 0.1 0.099 12.6 0.1 1.2 1 0 0 1 1 1 0 Lipoprotein GNA1870 C terminal like Laminin_EGF PF00053.24 EFC35963.1 - 0.31 11.2 13.4 0.7 10.1 13.4 1.6 1 0 0 1 1 1 0 Laminin EGF domain EGF_2 PF07974.13 EFC35963.1 - 0.41 11.1 17.7 0.057 13.8 12.6 2.2 2 0 0 2 2 2 0 EGF-like domain EGF_Tenascin PF18720.1 EFC35963.1 - 0.55 10.3 7.7 0.15 12.1 4.3 1.8 2 0 0 2 2 2 0 Tenascin EGF domain DDE_3 PF13358.6 EFC35964.1 - 1.4e-06 28.1 0.9 0.00013 21.8 0.9 2.8 1 1 0 1 1 1 1 DDE superfamily endonuclease p450 PF00067.22 EFC35966.1 - 2.1e-29 102.6 0.9 2.4e-29 102.4 0.9 1.0 1 0 0 1 1 1 1 Cytochrome P450 Coa1 PF08695.10 EFC35966.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 dCache_1 PF02743.18 EFC35967.1 - 0.00026 20.8 3.6 0.00048 20.0 3.6 1.4 1 0 0 1 1 1 1 Cache domain NucS PF01939.16 EFC35967.1 - 0.0058 16.0 0.0 0.0097 15.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease NucS SGL PF08450.12 EFC35969.1 - 0.013 15.1 0.0 4.3 6.8 0.0 2.7 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region tify PF06200.14 EFC35969.1 - 0.032 13.6 0.1 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 tify domain NHL PF01436.21 EFC35969.1 - 0.53 10.4 4.7 2.4 8.3 0.1 3.6 4 0 0 4 4 4 0 NHL repeat BTB_2 PF02214.22 EFC35970.1 - 3.2e-11 43.4 0.9 5.1e-11 42.8 0.3 1.6 2 0 0 2 2 2 1 BTB/POZ domain Insulin_TMD PF17870.1 EFC35971.1 - 0.00043 20.3 2.5 0.0011 19.0 2.5 1.7 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment DUF2782 PF11191.8 EFC35971.1 - 0.019 15.2 0.4 0.038 14.2 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2782) DUF2273 PF10031.9 EFC35971.1 - 0.029 14.4 3.6 0.053 13.6 3.6 1.4 1 0 0 1 1 1 0 Small integral membrane protein (DUF2273) DUF2207 PF09972.9 EFC35971.1 - 0.069 11.9 0.0 0.57 8.9 0.0 1.9 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Baculo_11_kDa PF06143.11 EFC35971.1 - 0.072 12.7 0.0 0.33 10.6 0.0 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF5385 PF17359.2 EFC35971.1 - 0.089 12.3 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Chordopox_A13L PF05961.11 EFC35971.1 - 0.11 12.8 0.2 0.31 11.3 0.2 1.8 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Sigma_reg_N PF13800.6 EFC35971.1 - 0.14 12.4 5.1 1.7 9.0 0.2 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF2206 PF09971.9 EFC35971.1 - 0.16 10.7 2.9 6.6 5.4 0.1 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2206) TMEM154 PF15102.6 EFC35971.1 - 0.26 11.2 0.0 0.26 11.2 0.0 2.4 2 1 1 3 3 3 0 TMEM154 protein family DHHC PF01529.20 EFC35971.1 - 0.27 11.3 1.2 6.4 6.9 0.0 2.7 3 0 0 3 3 3 0 DHHC palmitoyltransferase ETRAMP PF09716.10 EFC35971.1 - 0.6 10.2 7.7 1.2 9.2 7.7 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Filament PF00038.21 EFC35972.1 - 0.051 13.1 0.2 0.071 12.7 0.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein WD40 PF00400.32 EFC35973.1 - 8.5e-06 26.4 2.8 0.78 10.7 0.2 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat WD40_like PF17005.5 EFC35973.1 - 0.007 15.7 1.2 0.048 13.0 0.1 2.3 1 1 2 3 3 3 1 WD40-like domain ANAPC4_WD40 PF12894.7 EFC35973.1 - 0.0076 16.5 0.0 5.6 7.3 0.0 3.1 1 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1624 PF07786.12 EFC35974.1 - 0.054 13.1 0.2 0.066 12.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1624) TetR_C_3 PF08362.11 EFC35974.1 - 0.084 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 YcdC-like protein, C-terminal region UPF0242 PF06785.11 EFC35976.1 - 0.0019 18.3 17.6 0.0019 18.3 17.6 2.5 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus HXXSHH PF07586.11 EFC35976.1 - 0.026 14.1 3.7 0.041 13.5 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1552) DUF3085 PF11284.8 EFC35976.1 - 0.11 12.9 0.0 0.36 11.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3085) MAD PF05557.13 EFC35977.1 - 2.3e-22 79.1 27.9 1.2e-18 66.9 1.7 2.4 1 1 1 2 2 2 2 Mitotic checkpoint protein DUF4201 PF13870.6 EFC35977.1 - 0.0018 18.0 17.4 0.0018 18.0 17.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4201) MerR-DNA-bind PF09278.11 EFC35977.1 - 0.082 13.4 4.5 0.83 10.2 0.2 3.0 3 0 0 3 3 3 0 MerR, DNA binding Orthopox_B11R PF07033.11 EFC35977.1 - 0.11 12.3 0.2 0.11 12.3 0.2 2.2 2 0 0 2 2 2 0 Orthopoxvirus B11R protein Seryl_tRNA_N PF02403.22 EFC35977.1 - 0.31 11.3 17.6 0.28 11.4 1.2 3.0 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain HemX PF04375.14 EFC35977.1 - 0.36 10.1 11.3 0.96 8.7 9.0 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase LMBR1 PF04791.16 EFC35977.1 - 0.77 8.6 6.5 0.85 8.4 6.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF445 PF04286.12 EFC35977.1 - 0.84 9.4 12.3 1 9.1 12.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) ATG16 PF08614.11 EFC35977.1 - 1 9.6 19.6 0.23 11.7 9.5 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) PRKG1_interact PF15898.5 EFC35977.1 - 1 10.3 18.9 3.5 8.6 14.5 2.8 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain AAA_11 PF13086.6 EFC35977.1 - 2.3 7.9 10.9 4.4 7.0 10.9 1.6 1 1 0 1 1 1 0 AAA domain LRRFIP PF09738.9 EFC35977.1 - 2.6 7.4 21.3 6.4 6.2 1.4 2.8 1 1 0 2 2 2 0 LRRFIP family DASH_Dad4 PF08650.10 EFC35977.1 - 2.7 8.0 11.2 4.8 7.2 0.6 3.8 3 1 1 4 4 4 0 DASH complex subunit Dad4 Allexi_40kDa PF05549.11 EFC35977.1 - 4.2 6.8 10.1 1.6 8.2 6.3 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein Cob_adeno_trans PF01923.18 EFC35977.1 - 5.4 7.1 8.3 21 5.2 0.3 2.3 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Cep57_MT_bd PF06657.13 EFC35977.1 - 5.7 7.5 17.1 4.6 7.8 1.2 3.6 2 1 2 4 4 3 0 Centrosome microtubule-binding domain of Cep57 Fzo_mitofusin PF04799.13 EFC35977.1 - 8 6.0 14.1 6.4 6.3 2.9 3.0 1 1 2 3 3 3 0 fzo-like conserved region PPV_E1_N PF00524.18 EFC35979.1 - 0.012 16.0 4.0 0.044 14.2 4.0 1.9 1 0 0 1 1 1 0 E1 Protein, N terminal domain DSPc PF00782.20 EFC35980.1 - 9e-24 83.8 0.1 9.7e-24 83.7 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC35980.1 - 2.5e-06 27.3 0.0 2.8e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC35980.1 - 0.0031 17.2 0.1 0.004 16.8 0.1 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Init_tRNA_PT PF04179.12 EFC35980.1 - 0.011 16.0 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain HTH_25 PF13413.6 EFC35981.1 - 0.01 15.7 0.2 0.44 10.5 0.0 2.9 1 1 1 2 2 2 1 Helix-turn-helix domain F-box-like PF12937.7 EFC35981.1 - 0.015 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC35981.1 - 0.04 13.8 0.9 0.062 13.2 0.1 1.7 2 0 0 2 2 2 0 F-box domain Put_Phosphatase PF06888.12 EFC35981.1 - 0.05 13.0 3.0 0.053 12.9 0.5 1.9 2 0 0 2 2 2 0 Putative Phosphatase PRANC PF09372.10 EFC35981.1 - 0.055 13.8 0.1 0.055 13.8 0.1 2.6 3 1 0 3 3 3 0 PRANC domain Glyco_hydro_79n PF03662.14 EFC35981.1 - 0.12 11.3 0.1 0.17 10.8 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain COMM_domain PF07258.14 EFC35981.1 - 0.3 11.2 3.8 0.21 11.7 1.2 2.1 2 0 0 2 2 2 0 COMM domain CENP-F_leu_zip PF10473.9 EFC35981.1 - 3.6 7.6 20.0 0.13 12.3 3.0 2.3 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 EFC35981.1 - 3.8 8.0 12.5 0.98 9.9 2.2 3.3 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SKA2 PF16740.5 EFC35981.1 - 5.3 6.9 11.4 17 5.2 2.9 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 PCRF PF03462.18 EFC35981.1 - 6.4 6.6 10.7 2e+02 1.7 10.7 2.0 1 1 0 1 1 1 0 PCRF domain Acetyltransf_1 PF00583.25 EFC35982.1 - 1.8e-15 57.2 0.0 2.2e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC35982.1 - 3.9e-12 46.4 0.1 5.4e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC35982.1 - 1e-11 44.9 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC35982.1 - 1.1e-06 29.4 0.0 1.3e-06 29.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC35982.1 - 7e-06 26.3 0.2 4e-05 23.8 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC35982.1 - 3.7e-05 23.8 0.0 7.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EFC35982.1 - 6.1e-05 22.6 1.7 0.00018 21.0 1.7 1.9 1 1 0 1 1 1 1 Putative acetyl-transferase FR47 PF08445.10 EFC35982.1 - 0.0003 20.7 0.0 0.00058 19.8 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 EFC35982.1 - 0.00049 19.8 0.0 0.00085 19.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ LRR_5 PF13306.6 EFC35982.1 - 0.0023 17.9 0.5 0.0036 17.3 0.5 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Acetyltransf_9 PF13527.7 EFC35982.1 - 0.0035 17.4 0.3 0.0091 16.1 0.2 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain zf-P11 PF03854.14 EFC35982.1 - 0.018 14.7 0.2 0.048 13.3 0.2 1.7 1 0 0 1 1 1 0 P-11 zinc finger Mss4 PF04421.13 EFC35982.1 - 0.043 14.0 0.7 0.11 12.6 0.2 1.8 1 1 0 2 2 2 0 Mss4 protein GNAT_acetyltran PF12746.7 EFC35982.1 - 0.045 13.3 0.1 0.085 12.4 0.1 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase LppA PF16708.5 EFC35982.1 - 0.058 13.3 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium PNKP_ligase PF16542.5 EFC35982.1 - 0.068 12.7 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain Pkinase PF00069.25 EFC35983.1 - 1.1e-06 28.2 0.0 1.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain SOG2 PF10428.9 EFC35983.1 - 0.095 11.9 17.5 0.1 11.8 17.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DSPc PF00782.20 EFC35984.1 - 5e-10 39.3 0.4 5e-10 39.3 0.4 3.5 3 1 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC35984.1 - 0.00038 20.1 0.4 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DUF4064 PF13273.6 EFC35985.1 - 0.12 12.6 13.5 2.3 8.5 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF5381 PF17353.2 EFC35985.1 - 0.21 11.3 0.1 0.21 11.3 0.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5381) DuoxA PF10204.9 EFC35985.1 - 1.5 7.8 15.8 0.14 11.2 10.8 1.7 2 1 0 2 2 2 0 Dual oxidase maturation factor DUF2207 PF09972.9 EFC35985.1 - 7.5 5.2 12.7 31 3.2 12.7 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Kinesin PF00225.23 EFC35988.1 - 5.2e-107 357.6 1.0 5.2e-107 357.6 1.0 2.8 1 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC35988.1 - 5.4e-21 75.1 1.2 5.4e-21 75.1 1.2 3.9 1 1 3 4 4 4 1 Microtubule binding MCM PF00493.23 EFC35989.1 - 5.7e-106 352.6 0.9 1.1e-105 351.7 0.9 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC35989.1 - 1.9e-39 134.4 0.2 4.5e-39 133.2 0.2 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFC35989.1 - 3.4e-27 94.7 2.0 1.2e-26 93.0 2.0 2.0 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFC35989.1 - 1.9e-07 30.7 0.0 5.8e-06 25.8 0.0 2.5 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 EFC35989.1 - 1.2e-05 25.9 0.1 1.2e-05 25.9 0.1 2.7 2 1 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 EFC35989.1 - 0.0001 22.2 0.0 0.00027 20.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFC35989.1 - 0.00056 19.9 0.0 0.0015 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFC35989.1 - 0.0017 18.0 0.3 0.0049 16.6 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain ADH_N_2 PF16884.5 EFC35990.1 - 2.7e-25 88.4 0.0 8.8e-25 86.7 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFC35990.1 - 4.5e-21 75.2 0.1 7.8e-21 74.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC35990.1 - 2.5e-10 41.5 0.0 6.6e-10 40.2 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EFC35990.1 - 0.0044 16.8 0.0 2.1 8.0 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2855) ELFV_dehydrog PF00208.21 EFC35990.1 - 0.075 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AMP-binding PF00501.28 EFC35991.1 - 9.6e-86 288.0 0.1 1.1e-85 287.8 0.1 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC35991.1 - 1.2e-16 61.5 0.2 3.4e-16 60.0 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DNA_pol_A PF00476.20 EFC35991.1 - 0.11 11.5 0.2 0.16 11.0 0.2 1.2 1 0 0 1 1 1 0 DNA polymerase family A RCC1_2 PF13540.6 EFC35992.1 - 4.7e-06 26.3 0.2 3.2e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC35992.1 - 0.0001 22.9 0.1 0.0011 19.5 0.0 2.8 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Kelch_6 PF13964.6 EFC35992.1 - 0.018 15.3 1.5 0.91 9.9 0.0 3.6 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 EFC35992.1 - 0.19 11.3 0.6 18 5.0 0.0 3.1 3 0 0 3 3 3 0 Kelch motif FRG1 PF06229.12 EFC35993.1 - 1.1e-31 110.1 0.0 3.3e-09 36.7 0.0 5.3 1 1 4 5 5 5 5 FRG1-like domain Fascin PF06268.13 EFC35993.1 - 2.5e-24 85.6 0.0 5.2e-08 33.1 0.0 4.1 1 1 3 4 4 4 4 Fascin domain EF-hand_7 PF13499.6 EFC35993.1 - 2.1e-09 37.7 0.1 3.3e-09 37.0 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC35993.1 - 6.5e-07 28.8 0.3 0.0052 16.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain DUF569 PF04601.13 EFC35993.1 - 5.2e-06 26.2 0.0 1.2 8.8 0.0 3.7 3 1 2 5 5 5 3 Domain of unknown function (DUF569) EF-hand_1 PF00036.32 EFC35993.1 - 0.00011 21.5 0.1 0.0093 15.5 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 EFC35993.1 - 0.0031 16.9 0.0 0.007 15.8 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EFC35993.1 - 0.024 14.5 0.1 0.098 12.5 0.0 1.9 1 1 1 2 2 2 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC35993.1 - 0.16 12.3 0.3 0.25 11.7 0.3 1.3 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region PAC2 PF09754.9 EFC35994.1 - 4.5e-16 59.5 0.0 5.6e-16 59.2 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Ank_2 PF12796.7 EFC35995.1 - 8.9e-25 87.1 1.9 9.3e-11 42.2 1.0 4.7 3 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC35995.1 - 3.5e-19 66.9 2.3 0.0083 16.6 0.1 7.3 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EFC35995.1 - 8.3e-18 64.2 2.1 0.073 13.4 0.0 6.3 3 2 3 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC35995.1 - 2.4e-16 59.9 0.6 0.011 16.3 0.0 5.2 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC35995.1 - 3.3e-13 49.4 0.9 0.00045 20.5 0.2 5.0 5 0 0 5 5 5 2 Ankyrin repeat TLD PF07534.16 EFC35996.1 - 5.1e-10 39.7 1.5 1.3e-09 38.4 1.5 1.8 1 1 0 1 1 1 1 TLD Ribosomal_S3Ae PF01015.18 EFC35998.1 - 2.6e-23 82.7 4.6 3.8e-23 82.1 4.6 1.2 1 0 0 1 1 1 1 Ribosomal S3Ae family LBP_BPI_CETP PF01273.25 EFC35998.1 - 0.034 13.7 0.6 0.067 12.8 0.1 1.6 2 0 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain Peptidase_M56 PF05569.11 EFC35999.1 - 0.00065 19.0 0.3 0.0037 16.5 0.1 1.9 2 0 0 2 2 2 1 BlaR1 peptidase M56 Orf78 PF06024.12 EFC35999.1 - 0.0047 17.2 4.7 0.011 16.0 1.0 2.3 2 1 0 2 2 2 1 Orf78 (ac78) Nodulin-like PF06813.13 EFC35999.1 - 0.0063 16.0 3.9 0.056 12.9 0.4 2.2 2 0 0 2 2 2 1 Nodulin-like CD34_antigen PF06365.12 EFC35999.1 - 0.0069 16.0 0.3 1.8 8.1 0.1 2.2 2 0 0 2 2 2 2 CD34/Podocalyxin family DUF2207 PF09972.9 EFC35999.1 - 0.034 12.9 0.1 0.048 12.4 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EFC35999.1 - 0.052 13.6 0.2 3.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Ctr PF04145.15 EFC35999.1 - 0.082 13.5 2.3 0.19 12.3 2.3 1.6 1 1 0 1 1 1 0 Ctr copper transporter family DUF2663 PF10864.8 EFC35999.1 - 0.1 13.0 2.2 0.62 10.5 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) DUF4064 PF13273.6 EFC35999.1 - 0.16 12.3 4.3 0.5 10.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) EphA2_TM PF14575.6 EFC35999.1 - 0.19 12.6 1.5 0.62 11.0 0.0 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ETRAMP PF09716.10 EFC35999.1 - 0.28 11.3 3.1 12 6.0 0.1 2.7 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Sigma_reg_N PF13800.6 EFC35999.1 - 0.3 11.4 3.9 7.6 6.9 0.6 2.7 2 1 0 2 2 2 0 Sigma factor regulator N-terminal TAP_C PF03943.13 EFC36000.1 - 4.7e-16 58.2 0.5 9.8e-11 41.1 0.2 3.3 2 1 1 3 3 3 3 TAP C-terminal domain UBA_4 PF14555.6 EFC36000.1 - 1.9e-06 27.6 1.3 0.14 12.0 0.3 3.4 3 0 0 3 3 3 2 UBA-like domain DUF1110 PF06533.12 EFC36000.1 - 0.049 13.6 0.1 0.075 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) VWA_2 PF13519.6 EFC36002.1 - 4.4e-12 46.6 0.0 6.9e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC36002.1 - 4.6e-08 33.5 0.0 6.4e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain TssR PF17643.1 EFC36002.1 - 0.027 12.4 0.0 0.031 12.3 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR VWA_3 PF13768.6 EFC36002.1 - 0.047 13.6 0.0 0.081 12.9 0.0 1.4 1 1 0 1 1 1 0 von Willebrand factor type A domain SeleniumBinding PF11524.8 EFC36003.1 - 0.05 14.0 0.8 2.4 8.6 0.0 2.5 1 1 1 2 2 2 0 Selenium binding protein DNA_topoisoIV PF00521.20 EFC36004.1 - 0.017 14.0 0.1 0.02 13.8 0.1 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A EAF PF09816.9 EFC36005.1 - 5e-16 59.0 1.4 5e-16 59.0 1.4 2.1 2 1 0 2 2 2 1 RNA polymerase II transcription elongation factor DUF4856 PF16148.5 EFC36005.1 - 0.14 11.1 14.4 0.29 10.1 14.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4856) SNARE PF05739.19 EFC36006.1 - 0.0071 16.3 0.4 0.0071 16.3 0.4 2.7 3 0 0 3 3 3 1 SNARE domain AI-2E_transport PF01594.16 EFC36006.1 - 0.055 12.6 0.2 0.055 12.6 0.2 2.5 2 1 1 3 3 3 0 AI-2E family transporter YscO-like PF16789.5 EFC36006.1 - 0.45 10.5 13.8 0.18 11.8 9.7 2.0 1 1 0 2 2 2 0 YscO-like protein ALMT PF11744.8 EFC36006.1 - 5.7 5.7 14.5 7.9 5.2 14.3 1.3 1 1 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S8 PF00082.22 EFC36008.1 - 7.5e-40 137.0 4.5 1.7e-39 135.9 4.5 1.6 1 0 0 1 1 1 1 Subtilase family DUF3494 PF11999.8 EFC36008.1 - 1.4e-05 24.8 1.2 6.6e-05 22.6 1.2 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3494) RRM_1 PF00076.22 EFC36009.1 - 4.3e-17 61.7 0.1 1e-16 60.5 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 EFC36009.1 - 0.11 12.5 27.2 0.14 12.2 27.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Trypan_PARP PF05887.11 EFC36010.1 - 6.2e-07 29.5 112.8 0.026 14.5 37.1 3.1 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) DUF4116 PF13475.6 EFC36011.1 - 6.4e-25 86.6 14.1 2e-07 30.6 0.7 6.4 4 2 4 8 8 8 5 Domain of unknown function (DUF4116) Ras PF00071.22 EFC36011.1 - 0.00099 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Ras family Ubie_methyltran PF01209.18 EFC36011.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family NAD_binding_10 PF13460.6 EFC36012.1 - 4.2e-13 49.6 0.0 4.8e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC36012.1 - 8.9e-08 32.0 0.0 1e-07 31.8 0.0 1.0 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFC36012.1 - 3e-06 26.9 0.0 4.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EFC36012.1 - 0.00068 19.1 0.0 0.00089 18.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.19 EFC36012.1 - 0.0095 15.0 0.3 0.012 14.6 0.3 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC36012.1 - 0.013 14.9 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 EFC36012.1 - 0.015 15.5 0.1 0.025 14.7 0.1 1.3 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ATPgrasp_ST PF14397.6 EFC36012.1 - 0.022 14.0 0.1 0.026 13.8 0.1 1.1 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp SPA PF08616.10 EFC36013.1 - 2e-28 98.6 0.1 9.9e-28 96.4 0.1 2.4 1 0 0 1 1 1 1 Stabilization of polarity axis RGS PF00615.19 EFC36013.1 - 1.7e-09 38.0 1.8 2.1e-08 34.4 1.8 3.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain DENN PF02141.21 EFC36013.1 - 5.2e-07 29.8 1.5 5.2e-07 29.8 1.5 3.3 3 1 0 3 3 3 1 DENN (AEX-3) domain L_HMGIC_fpl PF10242.9 EFC36013.1 - 0.0078 16.4 0.0 0.025 14.8 0.0 1.8 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein DED PF01335.21 EFC36013.1 - 2.3 8.6 6.4 0.83 10.0 0.8 3.3 3 0 0 3 3 3 0 Death effector domain Ras PF00071.22 EFC36014.1 - 4e-06 26.5 0.0 6.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36014.1 - 0.0034 17.6 0.0 0.0061 16.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EFC36014.1 - 0.081 12.1 0.0 0.21 10.7 0.0 1.7 1 1 1 2 2 2 0 NB-ARC domain ABC_tran PF00005.27 EFC36014.1 - 0.14 12.7 0.0 0.26 11.8 0.0 1.5 1 1 0 1 1 1 0 ABC transporter OFCC1 PF15680.5 EFC36015.1 - 0.16 12.6 4.1 1.8 9.1 0.2 2.1 1 1 1 2 2 2 0 Orofacial cleft 1 candidate gene 1 protein DUF309 PF03745.14 EFC36016.1 - 0.15 11.8 0.1 0.26 11.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF309) DUF1729 PF08354.10 EFC36016.1 - 0.2 10.5 1.3 0.67 8.8 1.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1729) FXMRP1_C_core PF12235.8 EFC36017.1 - 0.4 11.3 6.2 0.39 11.3 4.6 1.7 1 1 1 2 2 2 0 Fragile X-related 1 protein core C terminal Ephrin_rec_like PF07699.13 EFC36019.1 - 0.14 12.0 10.8 0.039 13.7 7.0 2.1 1 1 0 1 1 1 0 Putative ephrin-receptor like cEGF PF12662.7 EFC36019.1 - 2.6 8.0 7.1 4 7.5 0.4 2.8 2 0 0 2 2 2 0 Complement Clr-like EGF-like Podoplanin PF05808.11 EFC36020.1 - 0.0021 18.2 1.6 0.0029 17.7 0.8 1.7 2 0 0 2 2 2 1 Podoplanin DUF4834 PF16118.5 EFC36020.1 - 0.0037 18.2 6.6 4 8.4 0.0 3.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4834) UK PF02512.14 EFC36020.1 - 0.031 14.8 1.1 0.067 13.7 0.4 1.9 2 1 0 2 2 2 0 Virulence determinant Wzy_C PF04932.15 EFC36020.1 - 0.061 13.0 0.0 7.7 6.1 0.0 2.1 2 0 0 2 2 2 0 O-Antigen ligase DUF2157 PF09925.9 EFC36020.1 - 0.078 12.8 0.4 0.56 10.0 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF2207 PF09972.9 EFC36020.1 - 0.31 9.8 2.7 0.17 10.6 0.2 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) GRP PF07172.11 EFC36020.1 - 0.45 11.2 2.6 1.1 10.0 1.7 2.2 2 1 0 2 2 2 0 Glycine rich protein family ABC2_membrane_3 PF12698.7 EFC36020.1 - 0.53 9.3 8.7 0.035 13.2 2.8 1.7 1 1 1 2 2 2 0 ABC-2 family transporter protein O-antigen_lig PF13425.6 EFC36020.1 - 4.7 5.9 9.9 1.1 8.0 2.3 2.0 1 1 1 2 2 2 0 O-antigen ligase like membrane protein TMEMspv1-c74-12 PF11044.8 EFC36020.1 - 9.2 6.3 6.2 12 5.9 0.1 2.7 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein RGS PF00615.19 EFC36021.1 - 5.6e-09 36.3 0.9 5.4e-08 33.1 0.9 2.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain Med20 PF08612.11 EFC36021.1 - 0.065 12.6 0.1 0.17 11.2 0.1 1.6 1 1 0 1 1 1 0 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Trypsin_2 PF13365.6 EFC36022.1 - 0.009 16.9 0.0 0.019 15.9 0.0 1.5 1 1 0 1 1 1 1 Trypsin-like peptidase domain nsp8 PF08717.10 EFC36024.1 - 0.0042 17.0 4.7 0.0084 16.0 4.7 1.4 1 0 0 1 1 1 1 nsp8 replicase RGS PF00615.19 EFC36025.1 - 2.4e-05 24.6 3.0 5.6e-05 23.4 3.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain PrgI PF12666.7 EFC36025.1 - 0.23 12.2 3.6 1 10.1 0.1 2.4 2 0 0 2 2 2 0 PrgI family protein Phage_holin_2_4 PF16082.5 EFC36025.1 - 4.6 7.0 5.6 3.4 7.5 0.5 2.5 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Transferase PF02458.15 EFC36026.1 - 2.2e-46 158.4 0.3 2.6e-46 158.2 0.3 1.0 1 0 0 1 1 1 1 Transferase family Guanylate_cyc PF00211.20 EFC36027.1 - 2e-08 34.1 0.6 5.2e-08 32.7 0.6 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Orf78 PF06024.12 EFC36027.1 - 0.98 9.8 5.7 0.23 11.8 1.6 2.0 2 0 0 2 2 2 0 Orf78 (ac78) T3RM_EcoP15I_C PF18273.1 EFC36027.1 - 9.7 6.6 9.6 0.41 11.0 0.4 3.3 4 0 0 4 4 4 0 Type III R-M EcoP15I C-terminal domain DUF4116 PF13475.6 EFC36028.1 - 1.1e-106 348.4 16.4 3e-16 58.9 0.0 7.7 3 2 5 9 9 9 9 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 EFC36028.1 - 0.015 15.3 0.9 4.6 7.3 0.1 3.8 3 2 2 5 5 5 0 Rsbr N terminal TctC PF03401.14 EFC36028.1 - 0.11 11.5 0.0 3.5 6.6 0.0 2.7 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter family receptor PH_14 PF17787.1 EFC36028.1 - 0.18 11.7 3.5 7.6 6.4 0.0 4.0 2 2 3 5 5 5 0 PH domain DUF3371 PF11851.8 EFC36028.1 - 0.28 12.3 1.0 1.6 9.8 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3371) DUF4668 PF15701.5 EFC36029.1 - 0.038 13.8 0.1 0.048 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) Ras PF00071.22 EFC36030.1 - 4.2e-05 23.2 0.0 9.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Ras family Pro_CA PF00484.19 EFC36032.1 - 1.8e-50 171.3 1.5 2e-50 171.1 1.5 1.0 1 0 0 1 1 1 1 Carbonic anhydrase Peptidase_C92 PF05708.12 EFC36033.1 - 1.4e-06 28.5 0.0 4.7e-05 23.5 0.0 2.3 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Guanylate_cyc PF00211.20 EFC36034.1 - 2.7e-55 186.8 0.3 1.2e-53 181.4 0.1 2.5 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC36034.1 - 9e-13 48.4 0.1 3.6e-12 46.4 0.1 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC36034.1 - 2e-07 31.0 0.1 1.9e-06 27.9 0.0 2.5 2 0 0 2 2 2 1 PAS fold DUF2153 PF09921.9 EFC36034.1 - 0.00021 21.1 4.5 0.25 11.2 0.2 2.9 2 0 0 2 2 2 2 Uncharacterized protein conserved in archaea (DUF2153) TAF1D PF15333.6 EFC36034.1 - 0.00099 18.9 6.1 0.081 12.7 1.9 2.5 2 0 0 2 2 2 2 TATA box-binding protein-associated factor 1D Ni_hydr_CYTB PF01292.20 EFC36034.1 - 0.0076 15.9 12.8 0.085 12.4 0.3 3.3 3 0 0 3 3 2 2 Prokaryotic cytochrome b561 Transposon_TraM PF12508.8 EFC36034.1 - 0.01 15.5 2.1 1.9 8.1 0.0 2.7 2 0 0 2 2 2 0 Conjugative transposon, TraM PAS_8 PF13188.7 EFC36034.1 - 0.065 13.3 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 PAS domain DUF2564 PF10819.8 EFC36034.1 - 0.39 11.1 2.5 31 5.1 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) DUF668 PF05003.12 EFC36034.1 - 1.1 9.7 3.3 53 4.4 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF668) E2 PF08199.11 EFC36034.1 - 7.2 6.6 8.5 39 4.3 1.0 3.6 4 0 0 4 4 4 0 Bacteriophage E2-like protein DUF2153 PF09921.9 EFC36035.1 - 0.056 13.3 0.7 0.12 12.2 0.7 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) TFIIF_alpha PF05793.12 EFC36036.1 - 0.0017 17.1 6.8 0.0026 16.5 6.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 EFC36036.1 - 0.006 14.9 0.2 0.0072 14.7 0.2 1.1 1 0 0 1 1 1 1 CDC45-like protein Podoplanin PF05808.11 EFC36036.1 - 0.31 11.1 2.0 0.61 10.2 2.0 1.4 1 0 0 1 1 1 0 Podoplanin Coilin_N PF15862.5 EFC36036.1 - 0.31 10.9 3.2 1.3 8.8 3.2 1.9 1 1 0 1 1 1 0 Coilin N-terminus YL1 PF05764.13 EFC36036.1 - 2.8 8.0 13.4 0.54 10.3 6.6 2.0 2 0 0 2 2 2 0 YL1 nuclear protein SPT6_acidic PF14632.6 EFC36036.1 - 5.6 7.6 10.9 57 4.4 10.6 2.3 1 1 0 1 1 1 0 Acidic N-terminal SPT6 DEAD PF00270.29 EFC36037.1 - 0.078 12.7 0.0 0.088 12.6 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF3841 PF12952.7 EFC36038.1 - 0.043 13.6 6.6 0.45 10.3 0.3 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF3841) F-box-like PF12937.7 EFC36039.1 - 0.0063 16.4 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 F-box-like WXG100 PF06013.12 EFC36039.1 - 0.17 12.2 3.5 0.49 10.7 2.3 2.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG F-box PF00646.33 EFC36039.1 - 0.21 11.5 0.4 0.21 11.5 0.4 1.7 2 0 0 2 2 2 0 F-box domain DUF1664 PF07889.12 EFC36039.1 - 0.33 11.0 9.1 0.63 10.1 3.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PRANC PF09372.10 EFC36039.1 - 0.36 11.2 0.1 0.36 11.2 0.1 3.1 1 1 1 3 3 3 0 PRANC domain HIP1_clath_bdg PF16515.5 EFC36039.1 - 1.1 9.9 18.1 0.19 12.4 11.6 2.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF948 PF06103.11 EFC36039.1 - 1.3 9.3 4.4 4.3 7.6 0.2 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Seryl_tRNA_N PF02403.22 EFC36039.1 - 2.3 8.5 16.0 2.2 8.6 2.9 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain YtxH PF12732.7 EFC36039.1 - 3.1 8.4 6.1 17 6.0 6.1 2.2 1 1 0 1 1 1 0 YtxH-like protein Tho1_MOS11_C PF18592.1 EFC36039.1 - 3.8 7.4 8.8 0.21 11.4 2.3 2.3 2 1 0 2 2 2 0 Tho1/MOS11 C-terminal domain TPR_1 PF00515.28 EFC36040.1 - 8.1e-05 22.3 0.8 0.14 12.1 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC36040.1 - 0.00024 21.0 1.5 0.034 14.2 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC36040.1 - 0.18 12.0 0.5 3.3 7.9 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat MRPL52 PF18699.1 EFC36040.1 - 0.99 9.6 3.3 2.1 8.6 0.2 2.2 2 0 0 2 2 2 0 Mitoribosomal protein mL52 EGF_2 PF07974.13 EFC36041.1 - 2.7e-12 46.8 38.9 1.4e-05 25.3 5.0 3.7 3 0 0 3 3 3 3 EGF-like domain EGF PF00008.27 EFC36041.1 - 0.0066 16.7 28.9 0.015 15.6 3.9 3.8 3 0 0 3 3 3 3 EGF-like domain EGF_Tenascin PF18720.1 EFC36041.1 - 0.037 14.1 1.0 0.037 14.1 1.0 3.6 3 0 0 3 3 3 0 Tenascin EGF domain Arf PF00025.21 EFC36042.1 - 1.1e-63 213.8 0.1 1.2e-63 213.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC36042.1 - 1e-13 51.2 0.0 1.1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC36042.1 - 9.7e-12 44.7 1.1 1.7e-08 34.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFC36042.1 - 1.2e-11 44.9 0.0 1.6e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC36042.1 - 7.2e-10 38.6 0.0 8.8e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC36042.1 - 4.8e-07 29.4 0.0 6.1e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC36042.1 - 0.00024 21.2 0.0 0.00034 20.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase TED_complement PF07678.14 EFC36043.1 - 0.019 14.0 0.0 0.019 14.0 0.0 1.1 1 0 0 1 1 1 0 A-macroglobulin TED domain HSP70 PF00012.20 EFC36044.1 - 6.7e-25 87.3 0.0 1.9e-24 85.9 0.0 1.7 2 0 0 2 2 2 1 Hsp70 protein RskA PF10099.9 EFC36044.1 - 0.053 13.8 0.3 5.8 7.2 0.0 2.8 3 0 0 3 3 3 0 Anti-sigma-K factor rskA DUF1143 PF06608.11 EFC36044.1 - 0.068 13.2 0.3 0.17 11.9 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1143) DUF4116 PF13475.6 EFC36045.1 - 2.8e-44 148.6 22.6 1.8e-13 50.0 0.0 7.7 5 3 2 7 7 7 7 Domain of unknown function (DUF4116) DNA_alkylation PF08713.11 EFC36046.1 - 4.4e-40 137.7 0.2 5.3e-40 137.4 0.2 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme Rab5-bind PF09311.11 EFC36046.1 - 0.081 12.3 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Rabaptin-like protein NHL PF01436.21 EFC36048.1 - 3.5e-29 99.3 8.8 3.3e-05 23.7 0.1 7.3 7 0 0 7 7 7 6 NHL repeat BTB PF00651.31 EFC36048.1 - 2.5e-09 37.3 0.4 2.5e-09 37.3 0.4 2.4 3 0 0 3 3 3 1 BTB/POZ domain Linker_histone PF00538.19 EFC36048.1 - 1.3e-07 31.9 0.7 17 5.9 0.0 6.3 6 0 0 6 6 6 0 linker histone H1 and H5 family PCMT PF01135.19 EFC36048.1 - 0.00068 19.4 2.6 0.5 10.1 0.0 5.2 3 1 3 7 7 7 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Plasmo_rep PF12135.8 EFC36048.1 - 0.003 17.0 28.0 1.7 8.3 0.6 6.8 6 0 0 6 6 6 3 Plasmodium repeat family Maf PF02545.14 EFC36048.1 - 0.005 16.7 0.0 1.7e+02 1.9 0.0 5.6 3 1 3 6 6 6 0 Maf-like protein DUF3420 PF11900.8 EFC36048.1 - 0.011 15.8 3.1 43 4.3 0.0 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF3420) DUF4350 PF14258.6 EFC36048.1 - 0.015 15.7 0.0 41 4.7 0.0 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4350) Coatomer_WDAD PF04053.14 EFC36048.1 - 0.035 13.2 8.1 5.1 6.0 0.1 3.9 1 1 2 3 3 3 0 Coatomer WD associated region KdpD PF02702.17 EFC36048.1 - 0.074 12.5 0.0 1.2e+02 2.1 0.0 4.8 6 0 0 6 6 6 0 Osmosensitive K+ channel His kinase sensor domain S4_2 PF13275.6 EFC36048.1 - 0.29 11.0 7.0 15 5.5 0.1 4.5 5 0 0 5 5 5 0 S4 domain TRL PF13146.6 EFC36048.1 - 3.6 7.9 11.0 23 5.4 0.0 5.5 6 0 0 6 6 6 0 TRL-like protein family TPP_enzyme_C PF02775.21 EFC36048.1 - 7.8 6.3 13.1 8.7 6.1 0.3 4.1 3 2 2 5 5 5 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPR_9 PF13371.6 EFC36049.1 - 0.00063 19.8 0.0 0.0013 18.9 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC36049.1 - 0.013 15.8 0.0 0.031 14.6 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36049.1 - 0.014 15.2 0.0 0.034 14.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC36049.1 - 0.027 14.6 0.0 0.083 13.0 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat YkyA PF10368.9 EFC36049.1 - 0.036 13.7 3.4 0.087 12.5 3.4 1.7 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein TPR_14 PF13428.6 EFC36049.1 - 0.042 14.7 0.1 0.19 12.7 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC36049.1 - 0.05 13.5 1.7 2.4 8.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC36049.1 - 0.057 13.7 0.2 0.37 11.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CTD_bind PF04818.13 EFC36049.1 - 0.08 13.8 0.2 0.21 12.4 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase II-binding domain. Alpha-mann_mid PF09261.11 EFC36049.1 - 0.12 12.6 0.1 0.35 11.0 0.1 1.8 1 1 0 1 1 1 0 Alpha mannosidase middle domain PPR PF01535.20 EFC36049.1 - 4.3 7.8 5.6 2.4 8.6 0.1 3.2 3 0 0 3 3 3 0 PPR repeat Ank_3 PF13606.6 EFC36051.1 - 2.1e-08 33.8 2.5 0.76 10.5 0.0 6.1 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFC36051.1 - 5.2e-08 33.0 0.1 0.62 10.5 0.0 4.7 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC36051.1 - 1.9e-06 28.3 1.8 0.013 16.1 0.0 4.5 3 1 2 5 5 5 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC36051.1 - 4.3e-06 27.2 3.0 0.001 19.6 0.1 3.6 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFC36051.1 - 0.00036 20.9 10.5 4.2 8.0 0.0 5.5 5 1 0 5 5 5 1 Ankyrin repeat Peripla_BP_1 PF00532.21 EFC36051.1 - 0.02 14.3 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Ribosomal_L6e PF01159.19 EFC36051.1 - 0.16 12.6 8.6 1.4 9.5 3.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L6e FAM176 PF14851.6 EFC36051.1 - 0.68 9.6 7.7 3.4 7.3 4.9 2.2 2 0 0 2 2 2 0 FAM176 family Orf78 PF06024.12 EFC36051.1 - 8.4 6.8 12.7 0.23 11.8 2.5 2.4 2 0 0 2 2 2 0 Orf78 (ac78) FOXP-CC PF16159.5 EFC36052.1 - 0.024 15.3 5.3 1.4 9.6 0.5 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain PBECR3 PF18812.1 EFC36052.1 - 0.028 14.4 0.1 0.052 13.5 0.1 1.4 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 zf-C2H2_jaz PF12171.8 EFC36052.1 - 0.13 12.6 12.4 0.41 11.0 0.4 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 EFC36052.1 - 0.94 10.1 16.3 2.2 8.9 4.0 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf_ZIC PF18366.1 EFC36052.1 - 7.6 6.7 15.4 0.32 11.1 7.4 2.6 2 1 1 3 3 3 0 Zic proteins zinc finger domain NMT1_3 PF16868.5 EFC36053.1 - 0.044 13.2 5.5 0.11 11.9 0.1 3.0 3 0 0 3 3 3 0 NMT1-like family WD40 PF00400.32 EFC36054.1 - 1.9e-26 91.7 13.4 0.016 16.1 0.1 10.4 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36054.1 - 2.6e-10 40.4 0.0 4.7e-05 23.6 0.0 5.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 EFC36054.1 - 2.3e-08 33.8 0.0 4.6e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 HELP motif FAD_binding_2 PF00890.24 EFC36055.1 - 2.2e-71 241.2 0.0 2.2e-71 241.2 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFC36055.1 - 2.7e-10 40.4 0.1 6.5e-10 39.1 0.1 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC36055.1 - 1.1e-06 28.8 0.9 3.1e-06 27.3 0.9 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFC36055.1 - 4.9e-06 26.0 4.3 4.1e-05 22.9 4.3 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFC36055.1 - 1e-05 25.1 2.8 1e-05 25.1 2.8 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 EFC36055.1 - 5.9e-05 22.5 0.2 0.00016 21.0 0.2 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EFC36055.1 - 0.00027 20.2 1.5 0.00027 20.2 1.5 3.4 4 1 1 5 5 3 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFC36055.1 - 0.00054 18.8 1.4 0.00054 18.8 1.4 3.7 4 1 0 4 4 4 1 HI0933-like protein FAD_binding_3 PF01494.19 EFC36055.1 - 0.00072 18.9 0.5 0.00072 18.9 0.5 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EFC36055.1 - 0.0012 19.3 2.6 0.005 17.4 1.1 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SOG2 PF10428.9 EFC36055.1 - 0.003 16.8 23.8 0.0053 16.0 23.8 1.4 1 0 0 1 1 1 1 RAM signalling pathway protein Thi4 PF01946.17 EFC36055.1 - 0.01 15.1 0.3 0.13 11.5 0.1 2.2 2 0 0 2 2 2 0 Thi4 family Ribosomal_L18p PF00861.22 EFC36055.1 - 0.014 15.7 0.1 0.05 14.0 0.1 1.9 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast TFIIA PF03153.13 EFC36055.1 - 0.32 10.9 18.8 0.21 11.5 16.3 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 EFC36056.1 - 5.9e-66 222.5 0.0 1.1e-65 221.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36056.1 - 5.3e-24 84.9 0.0 7.8e-24 84.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC36056.1 - 1.2e-07 31.4 0.0 5.9e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like FTA2 PF13095.6 EFC36056.1 - 0.052 13.2 0.6 0.83 9.2 0.0 2.6 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFC36056.1 - 0.065 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family GREB1 PF15782.5 EFC36056.1 - 5.4 4.0 14.6 6.9 3.6 14.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 EFC36056.1 - 6.4 5.2 19.5 8.5 4.8 19.5 1.1 1 0 0 1 1 1 0 Macoilin family AMP-binding PF00501.28 EFC36057.1 - 4e-92 309.0 0.0 4.8e-92 308.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC36057.1 - 1.9e-15 57.6 0.1 3.5e-15 56.7 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Malic_M PF03949.15 EFC36058.1 - 1.9e-87 292.8 0.2 2.4e-87 292.4 0.2 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFC36058.1 - 1.1e-72 243.7 0.0 1.9e-72 242.9 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Pyr_redox_2 PF07992.14 EFC36058.1 - 0.12 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase BTB_2 PF02214.22 EFC36059.1 - 6.4e-18 64.9 4.5 2.8e-16 59.7 0.2 2.4 2 0 0 2 2 2 2 BTB/POZ domain CENP-K PF11802.8 EFC36059.1 - 0.00036 20.2 4.2 0.0005 19.7 4.2 1.3 1 0 0 1 1 1 1 Centromere-associated protein K DUF3552 PF12072.8 EFC36059.1 - 0.17 11.3 7.9 0.23 10.9 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Exonuc_VII_L PF02601.15 EFC36059.1 - 0.42 10.1 2.4 0.5 9.9 2.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_M17 PF00883.21 EFC36061.1 - 9.3e-105 350.3 0.0 1.2e-104 349.9 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EFC36061.1 - 0.027 14.3 1.8 0.053 13.4 0.1 2.4 3 1 0 3 3 3 0 Cytosol aminopeptidase family, N-terminal domain DUF4116 PF13475.6 EFC36063.1 - 2.7e-25 87.8 6.0 9.4e-08 31.7 0.1 4.2 3 1 2 5 5 5 4 Domain of unknown function (DUF4116) PARG_cat PF05028.14 EFC36063.1 - 0.03 13.6 0.1 0.047 13.0 0.1 1.3 1 0 0 1 1 1 0 Poly (ADP-ribose) glycohydrolase (PARG) LRR_6 PF13516.6 EFC36064.1 - 6.7e-60 194.1 4.8 0.0043 17.0 0.0 14.1 14 0 0 14 14 14 14 Leucine Rich repeat LRR_8 PF13855.6 EFC36064.1 - 7.2e-48 160.2 22.1 4.6e-09 35.9 0.0 6.2 1 1 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC36064.1 - 6.9e-42 140.8 32.9 0.00028 21.2 0.1 8.2 1 1 12 13 13 13 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36064.1 - 5.8e-26 87.0 0.0 19 6.3 0.0 13.8 14 0 0 14 14 14 4 Leucine Rich Repeat RHH_3 PF12651.7 EFC36064.1 - 2.3e-16 59.4 1.2 0.3 11.1 0.0 9.9 6 2 5 11 11 11 4 Ribbon-helix-helix domain UPF0193 PF05250.11 EFC36064.1 - 4.2 7.1 8.7 12 5.7 0.2 3.6 3 2 2 5 5 5 0 Uncharacterised protein family (UPF0193) LRR_6 PF13516.6 EFC36065.1 - 4e-18 63.9 0.0 0.01 15.8 0.0 4.1 4 0 0 4 4 4 4 Leucine Rich repeat LRR_8 PF13855.6 EFC36065.1 - 1.1e-11 44.3 1.6 8e-08 31.9 0.1 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFC36065.1 - 2.5e-10 40.5 0.1 0.00051 20.4 0.0 2.5 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) RHH_3 PF12651.7 EFC36065.1 - 3.1e-09 36.6 0.2 0.043 13.8 0.0 3.8 1 1 3 4 4 4 3 Ribbon-helix-helix domain LRR_1 PF00560.33 EFC36065.1 - 4e-06 26.6 0.0 28 5.8 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat UPF0193 PF05250.11 EFC36065.1 - 0.0088 15.9 2.4 1.8 8.3 0.2 2.0 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0193) Nucleic_acid_bd PF13820.6 EFC36065.1 - 0.058 13.2 0.1 1.9 8.3 0.0 2.3 1 1 1 2 2 2 0 Putative nucleic acid-binding region DUF2634 PF10934.8 EFC36065.1 - 0.68 10.1 4.4 16 5.7 0.1 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF2634) NHL PF01436.21 EFC36066.1 - 6.6e-08 32.2 0.0 0.0064 16.5 0.0 4.6 4 0 0 4 4 4 2 NHL repeat EGF_2 PF07974.13 EFC36066.1 - 2.2e-05 24.7 9.9 5.2e-05 23.5 9.9 1.6 1 0 0 1 1 1 1 EGF-like domain GPS PF01825.21 EFC36066.1 - 0.0032 18.0 0.4 0.0032 18.0 0.4 2.7 2 2 0 2 2 2 1 GPCR proteolysis site, GPS, motif EGF PF00008.27 EFC36066.1 - 0.11 12.8 4.2 0.3 11.4 4.2 1.8 1 0 0 1 1 1 0 EGF-like domain DUF1798 PF08807.10 EFC36066.1 - 0.11 12.6 0.1 0.24 11.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) RGS PF00615.19 EFC36068.1 - 9.1e-11 42.1 1.5 6.7e-10 39.3 1.5 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF241 PF03087.14 EFC36068.1 - 0.01 15.7 0.3 0.013 15.4 0.3 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function DUF4507 PF14964.6 EFC36068.1 - 0.015 14.2 0.1 0.022 13.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4507) RCC1_2 PF13540.6 EFC36069.1 - 0.0027 17.5 0.2 0.0061 16.3 0.2 1.6 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat DUF5022 PF16425.5 EFC36069.1 - 0.0032 16.9 0.0 0.0042 16.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5022) Exo_endo_phos PF03372.23 EFC36070.1 - 0.0096 15.5 0.1 0.0096 15.5 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2264 PF10022.9 EFC36071.1 - 0.036 13.2 0.0 0.05 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2264) Filo_VP24 PF06389.11 EFC36072.1 - 0.072 12.6 0.3 0.14 11.7 0.3 1.4 1 0 0 1 1 1 0 Filovirus membrane-associated protein VP24 Pkinase PF00069.25 EFC36073.1 - 3.7e-22 78.9 0.6 6.6e-22 78.1 0.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36073.1 - 1.8e-09 37.2 0.0 2.9e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 EFC36073.1 - 0.008 15.2 1.7 0.013 14.5 1.7 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 EFC36073.1 - 0.014 14.2 0.2 0.014 14.2 0.2 1.6 2 0 0 2 2 2 0 Fungal protein kinase Metallophos PF00149.28 EFC36075.1 - 2e-12 48.1 1.4 3.2e-12 47.4 1.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC36075.1 - 1.6e-09 38.2 0.0 4.1e-09 36.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain AAA_lid_5 PF17865.1 EFC36076.1 - 0.028 14.5 0.3 0.098 12.7 0.3 2.2 1 1 0 1 1 1 0 Midasin AAA lid domain DUF676 PF05057.14 EFC36077.1 - 2.5e-29 102.4 0.0 5.3e-29 101.3 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EFC36077.1 - 7.5e-06 25.9 0.0 2.2e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) PGAP1 PF07819.13 EFC36077.1 - 0.00014 21.7 0.2 0.00029 20.6 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 EFC36077.1 - 0.0058 16.5 0.0 0.013 15.4 0.0 1.8 1 1 0 1 1 1 1 Palmitoyl protein thioesterase DUF432 PF04254.13 EFC36077.1 - 0.12 12.6 0.2 3.6 7.8 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF432) CBFD_NFYB_HMF PF00808.23 EFC36079.1 - 3.2e-22 78.6 0.4 6.1e-22 77.7 0.4 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFC36079.1 - 1.4e-06 28.7 0.1 2.3e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFC36079.1 - 0.0047 17.0 0.0 0.0073 16.4 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAN_3 PF08277.12 EFC36079.1 - 0.0098 15.7 1.9 0.0098 15.7 1.9 2.1 2 0 0 2 2 2 1 PAN-like domain Pex14_N PF04695.13 EFC36081.1 - 2 9.1 11.9 2.4 8.8 1.4 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PhoLip_ATPase_C PF16212.5 EFC36082.1 - 2.2e-43 148.8 27.1 2.2e-43 148.8 27.1 3.0 3 0 0 3 3 3 2 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC36082.1 - 1.7e-10 40.5 11.5 7.3e-10 38.4 11.5 2.2 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 EFC36082.1 - 2.3e-09 37.9 0.0 3.3e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC36082.1 - 3.8e-08 33.3 0.4 3.1e-06 27.2 0.1 3.0 3 0 0 3 3 3 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFC36082.1 - 4.4e-06 26.4 0.5 4.4e-06 26.4 0.5 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFC36082.1 - 0.0053 16.5 0.1 0.0053 16.5 0.1 3.6 4 1 1 5 5 5 1 haloacid dehalogenase-like hydrolase IQ PF00612.27 EFC36083.1 - 0.98 9.4 3.6 13 5.9 0.1 3.4 3 0 0 3 3 3 0 IQ calmodulin-binding motif Thymidylat_synt PF00303.19 EFC36084.1 - 3.7e-110 367.3 0.1 5.2e-110 366.8 0.1 1.2 1 0 0 1 1 1 1 Thymidylate synthase DHFR_1 PF00186.19 EFC36084.1 - 2.1e-21 76.3 0.0 2.4e-17 63.1 0.0 2.4 2 0 0 2 2 2 2 Dihydrofolate reductase SWIM PF04434.17 EFC36085.1 - 3.4e-05 23.4 2.0 6.3e-05 22.5 2.0 1.4 1 0 0 1 1 1 1 SWIM zinc finger DUF4706 PF15797.5 EFC36085.1 - 0.066 13.7 0.1 0.11 13.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) TPR_12 PF13424.6 EFC36086.1 - 3.2e-07 30.6 0.0 0.00013 22.2 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC36086.1 - 9e-05 22.4 1.7 0.034 14.4 0.0 4.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC36086.1 - 0.0005 20.0 0.1 0.013 15.5 0.0 3.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC36086.1 - 0.0078 16.2 0.5 0.35 11.0 0.0 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36086.1 - 0.0079 16.0 0.0 0.047 13.5 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC36086.1 - 0.01 15.7 0.0 0.041 13.8 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC36086.1 - 0.1 13.5 0.0 2.3 9.3 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC36086.1 - 0.11 12.9 0.4 0.59 10.6 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat BET PF17035.5 EFC36087.1 - 0.05 13.8 0.0 0.081 13.1 0.0 1.4 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation ADH_N_2 PF16884.5 EFC36087.1 - 0.093 12.6 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase EGF_2 PF07974.13 EFC36088.1 - 5e-70 231.5 478.4 6.7e-05 23.2 10.9 29.0 28 1 1 29 29 29 26 EGF-like domain NHL PF01436.21 EFC36088.1 - 1.2e-05 25.1 0.0 0.016 15.2 0.0 3.3 2 0 0 2 2 2 2 NHL repeat EGF PF00008.27 EFC36088.1 - 0.0059 16.9 4.0 0.0059 16.9 4.0 28.5 28 0 0 28 28 28 10 EGF-like domain mRNA_triPase PF02940.15 EFC36089.1 - 5.3e-26 91.7 3.1 5.3e-26 91.7 3.1 2.3 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain DUF572 PF04502.13 EFC36089.1 - 0.0062 16.2 18.0 0.0062 16.2 18.0 1.6 2 0 0 2 2 2 1 Family of unknown function (DUF572) Med24_N PF11277.8 EFC36089.1 - 0.027 12.5 1.4 0.045 11.8 1.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Pox_Ag35 PF03286.14 EFC36089.1 - 0.85 9.4 20.9 3.7 7.3 0.5 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein BSP_II PF05432.11 EFC36089.1 - 0.86 9.2 23.1 0.11 12.2 2.0 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Ribosomal_60s PF00428.19 EFC36089.1 - 1 10.0 8.4 0.22 12.1 1.7 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Macoilin PF09726.9 EFC36089.1 - 2.3 6.7 18.9 0.58 8.6 13.3 2.0 2 0 0 2 2 2 0 Macoilin family PTPS_related PF10131.9 EFC36090.1 - 0.14 10.5 0.1 0.24 9.7 0.1 1.2 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein Toxin_15 PF07906.13 EFC36091.1 - 0.047 13.3 1.9 0.5 9.9 0.2 2.2 2 0 0 2 2 2 0 ShET2 enterotoxin, N-terminal region ATP-synt_C PF00137.21 EFC36092.1 - 6.6e-33 112.9 33.5 3.4e-20 72.1 12.6 2.2 2 0 0 2 2 2 2 ATP synthase subunit C PKD_2 PF16407.5 EFC36095.1 - 9.5e-05 22.6 0.3 0.01 16.0 0.0 3.4 2 1 0 2 2 2 1 PKD-like family EGF_2 PF07974.13 EFC36095.1 - 0.00018 21.8 21.8 0.00091 19.6 5.6 7.0 7 0 0 7 7 7 4 EGF-like domain EGF PF00008.27 EFC36095.1 - 0.0019 18.5 2.9 0.0019 18.5 2.9 6.4 6 0 0 6 6 6 3 EGF-like domain T2SSN PF01203.19 EFC36096.1 - 2 8.6 9.6 15 5.7 0.2 4.1 2 1 3 5 5 5 0 Type II secretion system (T2SS), protein N CDC48_2 PF02933.17 EFC36097.1 - 0.03 14.1 0.1 0.87 9.4 0.0 3.3 2 1 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 ADH_N PF08240.12 EFC36097.1 - 0.051 13.5 0.6 1.2 9.1 0.0 3.3 3 0 0 3 3 3 0 Alcohol dehydrogenase GroES-like domain DUF935 PF06074.12 EFC36097.1 - 0.1 11.3 1.2 0.17 10.6 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF935) NID PF07292.13 EFC36098.1 - 0.0027 18.3 1.0 0.51 11.0 0.0 3.4 3 0 0 3 3 3 1 Nmi/IFP 35 domain (NID) Orthopox_A5L PF06193.11 EFC36098.1 - 0.028 13.9 0.0 0.047 13.1 0.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like OGG_N PF07934.12 EFC36098.1 - 0.76 9.9 4.0 13 5.8 0.1 3.0 2 1 1 3 3 3 0 8-oxoguanine DNA glycosylase, N-terminal domain LRR_6 PF13516.6 EFC36099.1 - 1.3e-23 81.0 57.5 0.00051 19.9 1.0 10.3 10 1 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC36099.1 - 5.7e-11 42.5 67.9 0.00024 21.4 7.0 7.0 2 2 7 9 9 9 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36099.1 - 4.4e-09 36.0 41.7 1.6e-05 24.6 6.8 5.4 2 2 3 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 EFC36099.1 - 0.009 16.4 35.3 4.4 8.2 0.2 8.8 8 2 0 8 8 8 4 Leucine Rich Repeat PRKCSH-like PF12999.7 EFC36099.1 - 0.023 14.5 5.9 0.055 13.3 5.9 1.6 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Phage_Mu_Gam PF07352.12 EFC36099.1 - 0.37 10.7 18.4 0.081 12.8 1.4 2.4 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein DUF2129 PF09902.9 EFC36100.1 - 0.32 11.1 1.7 9 6.4 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2129) SWIM PF04434.17 EFC36102.1 - 1.1e-06 28.1 0.1 1.1e-06 28.1 0.1 2.0 2 0 0 2 2 2 1 SWIM zinc finger zf-RING_2 PF13639.6 EFC36102.1 - 0.00014 22.1 12.3 0.00014 22.1 12.3 2.2 3 0 0 3 3 3 1 Ring finger domain Rho_N PF07498.12 EFC36102.1 - 0.00052 19.9 0.0 0.00096 19.0 0.0 1.4 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain SAP PF02037.27 EFC36102.1 - 0.042 13.6 0.6 2.8 7.8 0.0 2.4 2 0 0 2 2 2 0 SAP domain RINGv PF12906.7 EFC36102.1 - 0.21 11.7 11.6 0.65 10.2 11.6 1.9 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.29 EFC36102.1 - 2.3 8.2 13.9 5.2 7.0 13.9 1.7 1 0 0 1 1 1 0 PHD-finger FAD-oxidase_C PF02913.19 EFC36103.1 - 6.6e-34 117.6 0.0 9.7e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFC36103.1 - 4e-33 114.1 0.0 7.7e-33 113.2 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain RGS PF00615.19 EFC36104.1 - 1.3e-13 51.2 5.6 1.3e-13 51.2 5.6 2.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain Cation_ATPase_C PF00689.21 EFC36104.1 - 0.066 12.9 1.6 0.073 12.8 0.1 1.8 3 0 0 3 3 3 0 Cation transporting ATPase, C-terminus OB_NTP_bind PF07717.16 EFC36105.1 - 5.6e-15 55.5 0.0 1e-14 54.7 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFC36105.1 - 3.1e-13 49.9 0.0 5.7e-13 49.1 0.0 1.5 1 1 0 1 1 1 1 Helicase associated domain (HA2) UPF0730 PF15827.5 EFC36105.1 - 0.085 12.6 0.1 0.26 11.0 0.1 1.8 1 0 0 1 1 1 0 UPF0730 unknown protein family CH PF00307.31 EFC36106.1 - 1.1e-22 80.2 0.0 1.8e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain SHOCT PF09851.9 EFC36106.1 - 5.2e-08 32.4 4.0 9.3e-08 31.6 4.0 1.4 1 0 0 1 1 1 1 Short C-terminal domain Prenyltrans PF00432.21 EFC36107.1 - 3.7e-43 144.9 4.2 1.5e-14 53.4 0.0 4.4 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 EFC36107.1 - 0.012 14.7 0.0 0.027 13.6 0.0 1.6 1 0 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EFC36107.1 - 0.024 13.7 0.0 10 5.1 0.0 2.9 2 2 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain Pro_CA PF00484.19 EFC36108.1 - 1.2e-36 126.4 0.1 2.8e-36 125.2 0.1 1.6 1 0 0 1 1 1 1 Carbonic anhydrase Macoilin PF09726.9 EFC36108.1 - 1.1 7.8 5.2 1.2 7.6 5.2 1.1 1 0 0 1 1 1 0 Macoilin family DUF305 PF03713.13 EFC36110.1 - 0.031 14.4 0.1 0.051 13.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF305) CoaE PF01121.20 EFC36111.1 - 0.00062 19.5 0.1 0.57 9.8 0.1 2.2 2 0 0 2 2 2 2 Dephospho-CoA kinase Trypan_PARP PF05887.11 EFC36112.1 - 7.6e-06 25.9 73.4 0.0034 17.4 35.8 2.2 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Sel1 PF08238.12 EFC36113.1 - 3e-49 164.4 12.9 6.7e-10 39.3 0.6 6.2 6 0 0 6 6 6 6 Sel1 repeat TPR_2 PF07719.17 EFC36113.1 - 0.00029 20.7 14.5 6.8 7.1 0.0 6.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC36113.1 - 0.026 14.8 0.7 83 3.6 0.1 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC36113.1 - 0.096 12.4 8.8 26 4.6 0.1 5.0 4 1 0 4 4 4 0 TPR repeat TPR_16 PF13432.6 EFC36113.1 - 0.2 12.4 0.6 25 5.6 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36113.1 - 0.3 11.0 18.2 31 4.6 0.1 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC36113.1 - 0.63 10.8 4.6 19 6.2 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC36113.1 - 5 7.6 21.4 15 6.1 0.0 6.8 9 1 0 9 9 9 0 Tetratricopeptide repeat C2 PF00168.30 EFC36114.1 - 2.6e-14 53.3 0.2 2.9e-13 50.0 0.0 2.4 2 0 0 2 2 2 1 C2 domain LRR_6 PF13516.6 EFC36115.1 - 1.6e-21 74.4 8.6 0.00018 21.3 0.1 6.3 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC36115.1 - 9e-14 51.0 4.4 0.00016 21.4 0.4 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC36115.1 - 1.5e-11 44.4 13.9 0.014 15.8 0.0 4.7 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36115.1 - 7.7e-05 22.7 11.3 4 8.4 0.2 6.0 6 1 0 6 6 6 2 Leucine Rich Repeat Toxin_30 PF08117.11 EFC36115.1 - 0.032 14.5 0.3 1 9.7 0.0 3.2 4 0 0 4 4 4 0 Ptu family LRR_6 PF13516.6 EFC36116.1 - 4.3e-37 123.0 21.9 0.0032 17.4 0.0 12.1 12 1 1 13 13 13 10 Leucine Rich repeat LRR_8 PF13855.6 EFC36116.1 - 2.7e-27 94.3 24.8 6.4e-07 29.0 0.2 5.9 2 2 5 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC36116.1 - 1.8e-20 72.7 23.8 0.00049 20.4 0.4 7.0 3 2 2 7 7 7 7 Leucine Rich repeats (2 copies) DUF4347 PF14252.6 EFC36116.1 - 1.1e-05 25.3 0.9 0.61 9.9 0.0 4.2 2 2 1 3 3 3 2 Domain of unknown function (DUF4347) LRR_9 PF14580.6 EFC36116.1 - 0.00029 20.4 7.5 0.037 13.5 1.0 3.3 1 1 1 3 3 3 2 Leucine-rich repeat ApoB100_C PF12491.8 EFC36116.1 - 0.00035 20.5 5.9 0.7 9.9 0.5 5.3 4 1 1 5 5 5 1 Apolipoprotein B100 C terminal LRR_1 PF00560.33 EFC36116.1 - 0.00037 20.6 9.5 1.1e+02 4.0 0.0 8.8 10 1 0 10 10 9 0 Leucine Rich Repeat Translat_reg PF01818.17 EFC36116.1 - 0.0038 17.2 0.7 2.9 7.9 0.0 3.6 2 2 1 3 3 3 1 Bacteriophage translational regulator DUF4869 PF16163.5 EFC36116.1 - 0.017 14.8 7.4 1.7 8.4 0.3 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4869) DUF4089 PF13318.6 EFC36116.1 - 0.24 11.9 0.1 45 4.6 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF4089) UPF0193 PF05250.11 EFC36116.1 - 0.9 9.3 4.3 3 7.6 0.8 2.7 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0193) Beta_helix PF13229.6 EFC36116.1 - 3 7.7 18.4 0.032 14.1 4.6 2.7 1 1 1 2 2 2 0 Right handed beta helix region EGF_2 PF07974.13 EFC36117.1 - 2.5e-102 334.8 702.7 0.00035 20.9 9.0 45.8 45 0 0 45 45 45 45 EGF-like domain ArgoMid PF16487.5 EFC36117.1 - 0.054 13.8 0.4 6 7.2 0.0 4.3 3 0 0 3 3 3 0 Mid domain of argonaute EGF_2 PF07974.13 EFC36118.1 - 7.9e-06 26.1 42.8 4.8e-05 23.6 5.9 25.5 28 5 3 31 31 31 12 EGF-like domain EGF PF00008.27 EFC36118.1 - 0.00027 21.2 7.7 0.00027 21.2 7.7 25.9 25 4 3 28 28 28 6 EGF-like domain DUF2283 PF10049.9 EFC36118.1 - 0.27 11.5 0.4 3 8.2 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2283) LRR_4 PF12799.7 EFC36119.1 - 3.5e-05 24.1 41.6 0.062 13.7 3.5 6.7 5 2 3 8 8 8 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC36119.1 - 0.0046 16.9 0.3 0.0046 16.9 0.3 7.1 8 0 0 8 8 8 3 Leucine Rich repeat DUF2690 PF10901.8 EFC36119.1 - 0.091 13.1 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2690) LRR_1 PF00560.33 EFC36119.1 - 0.12 13.0 26.4 4.3 8.3 0.4 8.8 8 1 0 8 8 8 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC36119.1 - 0.13 12.1 40.3 0.044 13.5 3.8 6.9 4 2 3 7 7 7 0 Leucine rich repeat E2F_CC-MB PF16421.5 EFC36120.1 - 1.1e-30 105.8 0.2 3.2e-30 104.4 0.2 1.8 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain E2F_TDP PF02319.20 EFC36120.1 - 1.3e-25 89.2 0.1 3.7e-25 87.8 0.1 1.8 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EFC36120.1 - 0.028 14.3 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 EFC36120.1 - 0.058 13.6 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC RHH_3 PF12651.7 EFC36122.1 - 0.053 13.5 0.1 0.19 11.7 0.1 2.0 1 0 0 1 1 1 0 Ribbon-helix-helix domain Zn_clus PF00172.18 EFC36123.1 - 4.1e-06 26.8 3.1 9e-06 25.7 3.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2368 PF10166.9 EFC36124.1 - 4.9e-14 52.1 0.1 5.7e-14 51.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) FH2 PF02181.23 EFC36125.1 - 7.7e-58 196.4 18.2 5.6e-42 144.2 12.1 4.7 2 2 1 4 4 4 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFC36125.1 - 1.9e-17 63.5 7.9 1.9e-17 63.5 7.9 4.5 3 2 2 5 5 5 1 Diaphanous FH3 Domain SlyX PF04102.12 EFC36125.1 - 1.1 9.9 9.2 6.2 7.5 0.7 4.3 3 0 0 3 3 3 0 SlyX Lipocalin PF00061.23 EFC36126.1 - 2.2e-08 34.4 0.0 2.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 EFC36126.1 - 7.7e-05 22.6 0.3 0.00012 22.0 0.3 1.4 1 1 0 1 1 1 1 Lipocalin-like domain Triabin PF03973.13 EFC36126.1 - 0.11 12.4 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Triabin Dynamin_N PF00350.23 EFC36127.1 - 0.05 13.7 0.1 0.05 13.7 0.1 3.7 4 0 0 4 4 4 0 Dynamin family SAM_1 PF00536.30 EFC36128.1 - 7.1e-18 64.8 1.1 7.1e-18 64.8 1.1 2.2 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC36128.1 - 1.4e-15 57.1 0.5 4.7e-15 55.4 0.5 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PB1 PF00564.24 EFC36128.1 - 1.3e-09 37.9 0.5 3.6e-09 36.4 0.5 1.8 1 0 0 1 1 1 1 PB1 domain SAM_3 PF18016.1 EFC36128.1 - 0.013 15.3 0.1 0.048 13.5 0.1 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EFC36128.1 - 0.043 13.8 1.2 0.059 13.4 0.1 1.8 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain HR1 PF02185.16 EFC36129.1 - 0.0064 16.6 1.1 0.0064 16.6 1.1 3.4 3 1 0 3 3 3 1 Hr1 repeat DivIC PF04977.15 EFC36129.1 - 0.0087 15.8 0.3 0.0087 15.8 0.3 3.9 4 1 0 4 4 4 2 Septum formation initiator Caenor_Her-1 PF09232.10 EFC36129.1 - 0.075 13.2 0.4 0.21 11.7 0.4 1.7 1 0 0 1 1 1 0 Caenorhabditis elegans Her-1 Cnd1 PF12717.7 EFC36129.1 - 0.14 12.2 2.1 0.47 10.5 2.1 1.9 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 LsmAD PF06741.13 EFC36129.1 - 0.28 11.8 8.4 0.47 11.0 0.2 3.7 2 1 1 3 3 3 0 LsmAD domain SlyX PF04102.12 EFC36129.1 - 6.5 7.5 17.0 17 6.1 0.5 4.3 3 1 0 3 3 3 0 SlyX Actin PF00022.19 EFC36130.1 - 9.6e-106 353.8 0.0 1.3e-104 350.1 0.0 1.9 1 1 0 1 1 1 1 Actin TetR_C_14 PF17754.1 EFC36130.1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 MftR C-terminal domain TRAM_LAG1_CLN8 PF03798.16 EFC36131.1 - 2.3e-37 128.7 20.5 2.3e-37 128.7 20.5 1.5 2 0 0 2 2 2 1 TLC domain DUF4834 PF16118.5 EFC36131.1 - 0.021 15.8 2.4 0.38 11.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) HemY_N PF07219.13 EFC36131.1 - 0.072 13.3 6.0 2.4 8.4 0.0 3.3 3 0 0 3 3 3 0 HemY protein N-terminus GWT1 PF06423.12 EFC36131.1 - 0.25 11.5 2.1 1.1 9.4 0.9 2.3 2 1 0 2 2 2 0 GWT1 DUF3899 PF13038.6 EFC36131.1 - 2 9.0 6.7 17 6.0 0.3 4.4 5 1 0 5 5 5 0 Domain of unknown function (DUF3899) Pkinase_Tyr PF07714.17 EFC36133.1 - 1.6e-24 86.6 0.0 2.7e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC36133.1 - 2.3e-22 79.6 0.1 4e-22 78.8 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Chlam_PMP PF02415.17 EFC36133.1 - 0.046 14.2 12.4 1.3 9.7 0.4 5.1 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Zn_clus PF00172.18 EFC36134.1 - 5.3e-09 36.1 14.4 9e-09 35.3 14.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Apolipoprotein PF01442.18 EFC36135.1 - 0.0014 18.5 1.8 0.011 15.6 1.8 2.0 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Prominin PF05478.11 EFC36135.1 - 0.0032 15.5 8.6 0.018 13.0 8.6 1.9 1 1 0 1 1 1 1 Prominin Uteroglobin PF01099.17 EFC36135.1 - 0.011 16.0 4.7 0.032 14.5 0.1 3.0 2 1 1 3 3 3 0 Uteroglobin family RhoGAP-FF1 PF16512.5 EFC36135.1 - 0.015 16.0 3.8 0.59 10.9 0.3 3.1 3 0 0 3 3 3 0 p190-A and -B Rho GAPs FF domain Clusterin PF01093.17 EFC36135.1 - 0.021 13.9 3.3 0.042 12.9 3.3 1.5 1 1 0 1 1 1 0 Clusterin NPA PF16469.5 EFC36135.1 - 0.052 14.1 1.3 0.052 14.1 1.3 2.2 2 1 0 2 2 2 0 Nematode polyprotein allergen ABA-1 Cor1 PF04803.12 EFC36135.1 - 0.052 13.8 10.0 0.12 12.6 0.6 2.5 2 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region ApoLp-III PF07464.11 EFC36135.1 - 0.053 13.6 13.4 3.9 7.5 3.6 3.2 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Serine_rich PF08824.10 EFC36135.1 - 0.065 13.2 10.7 0.075 13.0 1.2 2.2 1 1 1 2 2 2 0 Serine rich protein interaction domain DUF5601 PF18151.1 EFC36135.1 - 0.072 13.4 3.8 1.3 9.4 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5601) Fib_alpha PF08702.10 EFC36135.1 - 0.11 12.7 9.0 2 8.6 0.5 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Snapin_Pallidin PF14712.6 EFC36135.1 - 0.12 12.8 0.4 0.12 12.8 0.4 2.8 2 1 0 2 2 2 0 Snapin/Pallidin DUF4449 PF14613.6 EFC36135.1 - 0.12 12.5 3.0 0.38 10.8 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) DUF948 PF06103.11 EFC36135.1 - 0.13 12.5 14.9 2.3 8.6 3.5 4.0 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) ApoO PF09769.9 EFC36135.1 - 0.17 11.8 1.5 27 4.7 0.1 2.8 1 1 2 3 3 3 0 Apolipoprotein O Nbl1_Borealin_N PF10444.9 EFC36135.1 - 0.25 11.0 2.2 3.3 7.4 0.1 2.9 2 1 1 3 3 3 0 Nbl1 / Borealin N terminal DUF883 PF05957.13 EFC36135.1 - 0.29 11.8 2.8 14 6.4 0.1 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Phage_Mu_Gam PF07352.12 EFC36135.1 - 0.36 10.7 7.2 0.42 10.5 0.3 2.9 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein Exonuc_VII_L PF02601.15 EFC36135.1 - 0.5 9.9 5.1 0.99 8.9 5.1 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit Phasin PF05597.11 EFC36135.1 - 0.61 10.1 7.9 4.2 7.4 0.2 3.0 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.12 EFC36135.1 - 0.7 9.9 13.6 4.2 7.4 2.6 2.5 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 EFC36135.1 - 0.77 10.3 6.6 3.6e+02 1.8 6.6 3.3 1 1 0 1 1 1 0 YtxH-like protein DUF2130 PF09903.9 EFC36135.1 - 1.2 8.4 11.0 8.6 5.5 0.2 3.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2130) Mis12 PF05859.12 EFC36135.1 - 1.6 8.8 5.8 1.1e+02 2.8 5.8 2.8 1 1 0 1 1 1 0 Mis12 protein RNase_J_C PF17770.1 EFC36135.1 - 5.2 8.2 7.4 31 5.7 0.2 3.3 3 0 0 3 3 3 0 Ribonuclease J C-terminal domain RNase_H PF00075.24 EFC36136.1 - 3.1e-13 50.1 0.0 6.7e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 RNase H DUF98 PF01947.16 EFC36136.1 - 0.09 12.7 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 p-hydroxybenzoic acid synthase Lir1 PF07207.11 EFC36137.1 - 0.14 12.4 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 Light regulated protein Lir1 PulA_N1 PF17999.1 EFC36138.1 - 0.017 15.9 1.4 0.066 14.0 0.3 2.4 1 1 1 2 2 2 0 Pullulanase N1-terminal domain FA_hydroxylase PF04116.13 EFC36139.1 - 1e-25 90.6 13.3 1e-25 90.6 13.3 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily p450 PF00067.22 EFC36140.1 - 7.6e-08 31.5 0.0 1e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Exo_endo_phos PF03372.23 EFC36140.1 - 1.3e-05 24.8 0.0 6.2e-05 22.6 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pentapeptide PF00805.22 EFC36141.1 - 1.2e-17 63.1 27.4 1.7e-08 33.9 4.9 5.6 4 1 1 6 6 6 5 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC36141.1 - 1.1e-15 57.5 36.6 5.9e-08 32.8 5.7 4.5 1 1 2 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC36141.1 - 1.8e-10 40.8 33.9 4.6e-05 23.5 6.6 5.5 2 2 2 4 4 4 4 Pentapeptide repeats (9 copies) Mitochondr_Som1 PF11093.8 EFC36141.1 - 2.7 8.0 14.4 1.1 9.3 0.8 3.4 2 1 2 4 4 4 0 Mitochondrial export protein Som1 RGS PF00615.19 EFC36142.1 - 6.9e-11 42.4 1.1 1.7e-10 41.2 1.1 1.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain DicB PF05358.11 EFC36142.1 - 0.096 12.9 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 DicB protein Packaging_FI PF14000.6 EFC36145.1 - 0.6 10.6 5.1 0.16 12.4 1.3 2.0 2 0 0 2 2 2 0 DNA packaging protein FI DUF1151 PF06625.11 EFC36145.1 - 7.3 6.6 9.5 0.16 11.9 1.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1151) Herpes_UL14 PF03580.14 EFC36147.1 - 0.042 14.1 0.2 0.078 13.2 0.2 1.4 1 0 0 1 1 1 0 Herpesvirus UL14-like protein DUF4116 PF13475.6 EFC36148.1 - 1.6e-33 114.2 8.6 1.5e-07 31.0 0.1 5.6 2 2 3 6 6 6 6 Domain of unknown function (DUF4116) DUF1433 PF07252.11 EFC36148.1 - 0.068 13.4 0.1 0.62 10.3 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1433) Fe_dep_repr_C PF02742.15 EFC36148.1 - 0.14 12.2 0.2 0.32 11.1 0.2 1.5 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain LSM PF01423.22 EFC36149.1 - 1.8e-16 59.5 0.1 2.6e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 LSM domain SUIM_assoc PF16619.5 EFC36149.1 - 0.035 14.2 0.3 0.039 14.0 0.3 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 EFC36150.1 - 2.4e-05 23.8 0.2 4.7e-05 22.9 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFC36150.1 - 0.0066 16.4 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC36150.1 - 0.013 14.3 0.1 0.014 14.2 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase Cys_rich_CWC PF14375.6 EFC36151.1 - 0.071 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Cysteine-rich CWC TLD PF07534.16 EFC36152.1 - 1.2e-08 35.2 0.1 2.7e-08 34.1 0.1 1.6 1 0 0 1 1 1 1 TLD Laminin_EGF PF00053.24 EFC36152.1 - 3.5 7.9 114.2 1.5 9.0 10.3 7.4 1 1 5 6 6 6 0 Laminin EGF domain Ras PF00071.22 EFC36153.1 - 2.2e-05 24.1 0.0 4.6e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Ras family DUF3198 PF11433.8 EFC36153.1 - 0.0023 17.8 0.4 0.0023 17.8 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3198) Roc PF08477.13 EFC36153.1 - 0.0026 17.9 0.0 0.0045 17.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC36153.1 - 0.0075 16.1 0.3 0.017 15.0 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC36153.1 - 0.032 14.1 0.1 0.066 13.1 0.1 1.5 1 0 0 1 1 1 0 F-box-like PPR_2 PF13041.6 EFC36155.1 - 4e-33 113.4 13.6 1.2e-12 47.8 0.0 6.4 5 1 1 6 6 6 4 PPR repeat family PPR PF01535.20 EFC36155.1 - 1.6e-25 87.5 12.4 0.0013 18.8 0.0 9.2 9 0 0 9 9 9 5 PPR repeat PPR_3 PF13812.6 EFC36155.1 - 9.3e-15 54.5 0.9 3.8e-06 26.9 0.0 5.7 2 1 4 7 7 7 3 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC36155.1 - 3.3e-14 52.8 4.3 1.8e-06 27.5 0.3 3.9 2 1 2 4 4 4 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFC36155.1 - 2e-11 43.4 10.6 0.084 12.6 0.0 7.0 7 0 0 7 7 7 4 PPR repeat ANAPC3 PF12895.7 EFC36155.1 - 1.9e-08 34.4 1.7 0.11 12.8 0.0 4.6 3 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 ATP13 PF12921.7 EFC36155.1 - 1.5e-06 28.0 12.0 1.2 9.0 0.0 6.9 3 2 2 6 6 6 2 Mitochondrial ATPase expression TPR_1 PF00515.28 EFC36155.1 - 2.5e-06 27.0 3.0 0.89 9.5 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat FANCM-MHF_bd PF16783.5 EFC36155.1 - 2.8e-06 27.4 1.3 0.054 13.6 0.2 3.3 3 0 0 3 3 3 2 FANCM to MHF binding domain TPR_14 PF13428.6 EFC36155.1 - 1.3e-05 25.6 0.0 24 6.1 0.0 5.6 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC36155.1 - 2.3e-05 24.8 0.0 2.6 8.6 0.0 5.3 5 1 2 7 7 7 1 Tetratricopeptide repeat Mistic PF11458.8 EFC36155.1 - 0.00014 21.7 2.3 2.5 8.1 0.1 3.7 3 0 0 3 3 3 2 Membrane-integrating protein Mistic TPR_7 PF13176.6 EFC36155.1 - 0.0002 21.2 0.0 9.5 6.5 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC36155.1 - 0.00047 20.4 0.0 2.7 8.3 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.6 EFC36155.1 - 0.0018 17.7 2.8 2.3 7.6 0.1 3.4 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_8 PF13181.6 EFC36155.1 - 0.0068 16.5 4.7 68 4.1 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat INTS5_N PF14837.6 EFC36155.1 - 0.067 12.8 9.2 3.8 7.0 0.2 3.9 3 1 1 4 4 4 0 Integrator complex subunit 5 N-terminus PIH1 PF08190.12 EFC36156.1 - 0.18 11.2 0.2 0.27 10.7 0.2 1.2 1 0 0 1 1 1 0 PIH1 N-terminal domain Guanylate_cyc PF00211.20 EFC36157.1 - 0.008 15.8 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ribosomal_L38e PF01781.18 EFC36158.1 - 1.3e-18 66.8 5.3 2.8e-18 65.8 5.3 1.6 1 0 0 1 1 1 1 Ribosomal L38e protein family Glyco_hydro_59 PF02057.15 EFC36158.1 - 0.03 13.5 0.5 0.038 13.2 0.5 1.3 1 1 0 1 1 1 0 Glycosyl hydrolase family 59 LisH_2 PF16045.5 EFC36158.1 - 0.44 9.6 1.6 7.7 5.6 0.4 2.3 2 0 0 2 2 2 0 LisH NHL PF01436.21 EFC36159.1 - 9.2e-22 75.9 0.4 6.2e-07 29.1 0.1 5.2 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 EFC36159.1 - 8.8e-05 22.2 0.1 0.17 11.4 0.0 2.2 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region FlgD_ig PF13860.6 EFC36159.1 - 0.0076 16.1 0.4 1.6 8.6 0.1 2.9 3 0 0 3 3 3 2 FlgD Ig-like domain Phytase-like PF13449.6 EFC36159.1 - 0.026 14.5 0.0 6.2 6.7 0.0 2.8 1 1 2 3 3 3 0 Esterase-like activity of phytase P_gingi_FimA PF06321.11 EFC36160.1 - 0.022 14.9 0.3 0.032 14.3 0.3 1.3 1 0 0 1 1 1 0 Major fimbrial subunit protein (FimA) DKNYY PF13644.6 EFC36160.1 - 0.075 13.8 0.1 0.11 13.3 0.1 1.3 1 0 0 1 1 1 0 DKNYY family Pkinase PF00069.25 EFC36161.1 - 8.8e-25 87.6 0.9 1.1e-24 87.3 0.9 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36161.1 - 1.1e-14 54.4 0.3 1.3e-14 54.1 0.3 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC36161.1 - 0.15 12.0 0.0 0.16 11.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family RhoGAP PF00620.27 EFC36162.1 - 6.9e-30 103.9 3.6 1.5e-29 102.8 0.7 2.9 3 0 0 3 3 3 1 RhoGAP domain BAR_3 PF16746.5 EFC36162.1 - 0.22 11.2 23.6 0.44 10.2 18.5 2.9 2 1 0 2 2 2 0 BAR domain of APPL family Pkinase PF00069.25 EFC36163.1 - 6.1e-24 84.8 0.0 1e-23 84.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36163.1 - 2e-05 24.0 0.1 2.5e-05 23.7 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase STAR_dimer PF16544.5 EFC36163.1 - 1.6 8.3 3.9 3.4 7.3 0.2 2.7 3 0 0 3 3 3 0 Homodimerisation region of STAR domain protein DUF4116 PF13475.6 EFC36164.1 - 1.9e-42 142.8 25.4 9.1e-15 54.1 0.1 9.7 6 3 2 8 8 8 7 Domain of unknown function (DUF4116) DUF1160 PF06648.11 EFC36164.1 - 0.025 14.6 0.5 0.15 12.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) Exonuc_VIII PF06630.11 EFC36165.1 - 0.062 13.2 2.0 0.097 12.5 2.0 1.3 1 1 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII NPV_P10 PF05531.12 EFC36165.1 - 0.081 13.4 0.2 6.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein LapA_dom PF06305.11 EFC36165.1 - 0.18 11.6 3.5 0.52 10.2 0.2 2.6 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain Tmemb_cc2 PF10267.9 EFC36165.1 - 1.2 8.3 11.0 1.9 7.5 11.0 1.5 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein ZoocinA_TRD PF16775.5 EFC36168.1 - 0.016 15.3 0.0 0.03 14.5 0.0 1.4 1 0 0 1 1 1 0 Target recognition domain of lytic exoenzyme FdhE PF04216.12 EFC36168.1 - 0.062 13.2 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation DUF2039 PF10217.9 EFC36168.1 - 0.081 13.3 5.8 1.7 9.0 1.2 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) Baculo_IE-1 PF05290.11 EFC36168.1 - 6.7 6.7 9.2 3.1 7.7 4.0 2.8 2 2 1 3 3 3 0 Baculovirus immediate-early protein (IE-0) DSPc PF00782.20 EFC36169.1 - 1.2e-34 118.9 0.1 9.8e-34 116.0 0.0 2.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain LRR_4 PF12799.7 EFC36169.1 - 2.2e-16 59.6 86.4 3.8e-06 27.2 3.1 10.6 6 2 6 13 13 13 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36169.1 - 1.9e-13 49.9 67.8 7.2e-06 25.7 5.5 9.8 6 3 4 10 10 10 7 Leucine rich repeat Y_phosphatase PF00102.27 EFC36169.1 - 0.00089 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_6 PF13516.6 EFC36169.1 - 0.0036 17.2 49.0 0.6 10.3 3.0 10.7 10 0 0 10 10 10 4 Leucine Rich repeat Init_tRNA_PT PF04179.12 EFC36169.1 - 0.0066 16.7 1.1 0.024 14.9 0.2 2.4 2 0 0 2 2 2 1 Rit1 DUSP-like domain LRR_1 PF00560.33 EFC36169.1 - 0.026 15.0 57.3 1.7 9.5 0.6 13.3 12 1 0 12 12 12 0 Leucine Rich Repeat PTPlike_phytase PF14566.6 EFC36169.1 - 0.057 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Erf4 PF10256.9 EFC36170.1 - 5.9e-06 26.4 2.7 0.11 12.6 0.0 3.3 3 1 0 3 3 3 2 Golgin subfamily A member 7/ERF4 family ASFV_L11L PF05293.11 EFC36170.1 - 0.11 12.8 9.1 2.6 8.5 2.0 2.6 2 0 0 2 2 2 0 African swine fever virus (ASFV) L11L protein LRR_4 PF12799.7 EFC36171.1 - 1.6e-12 47.4 53.3 0.0012 19.2 7.0 10.0 8 1 0 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36171.1 - 6e-06 25.9 7.3 0.00013 21.6 5.1 8.8 7 2 3 10 10 10 2 Leucine rich repeat LRR_6 PF13516.6 EFC36171.1 - 0.00055 19.8 40.3 0.86 9.8 0.1 10.7 12 0 0 12 12 12 4 Leucine Rich repeat LRR_1 PF00560.33 EFC36171.1 - 3.3 8.6 40.5 13 6.8 1.8 10.8 9 1 0 9 9 9 0 Leucine Rich Repeat tRNA_bind PF01588.20 EFC36173.1 - 2.3e-24 85.3 0.1 3.8e-24 84.6 0.1 1.4 1 0 0 1 1 1 1 Putative tRNA binding domain Peptidase_S46 PF10459.9 EFC36173.1 - 0.098 11.3 0.3 0.12 11.0 0.3 1.0 1 0 0 1 1 1 0 Peptidase S46 RNA_pol_Rpb4 PF03874.16 EFC36173.1 - 0.12 12.7 5.5 7.3 6.9 5.5 2.5 1 1 0 1 1 1 0 RNA polymerase Rpb4 U-box PF04564.15 EFC36174.1 - 1e-15 57.7 0.1 4.5e-15 55.6 0.1 2.2 1 0 0 1 1 1 1 U-box domain Ank_2 PF12796.7 EFC36174.1 - 4.4e-09 36.8 0.2 0.00019 21.9 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC36174.1 - 5.1e-06 26.9 0.0 0.014 16.0 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC36174.1 - 4.8e-05 23.6 1.5 0.99 9.8 0.1 4.4 3 1 1 4 4 4 1 Ankyrin repeats (many copies) zf-Nse PF11789.8 EFC36174.1 - 0.067 13.0 0.0 0.53 10.2 0.0 2.3 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Ank_3 PF13606.6 EFC36174.1 - 0.087 13.4 1.3 44 5.1 0.1 4.1 4 0 0 4 4 4 0 Ankyrin repeat Chibby PF14645.6 EFC36175.1 - 1.9e-10 41.2 0.9 1.9e-10 41.2 0.9 2.3 2 0 0 2 2 2 1 Chibby family CAF-1_p150 PF11600.8 EFC36175.1 - 0.0066 16.2 24.1 0.01 15.5 24.1 1.3 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal FIST_C PF10442.9 EFC36175.1 - 0.028 14.4 0.0 0.035 14.1 0.0 1.3 1 0 0 1 1 1 0 FIST C domain GOLD_2 PF13897.6 EFC36175.1 - 0.24 11.9 4.7 0.84 10.1 4.8 1.7 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking RNA_pol_Rbc25 PF08292.12 EFC36175.1 - 0.64 10.3 5.4 0.88 9.8 5.4 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 FPN1 PF06963.12 EFC36175.1 - 0.66 8.5 1.2 0.82 8.2 1.2 1.1 1 0 0 1 1 1 0 Ferroportin1 (FPN1) Connexin PF00029.19 EFC36175.1 - 0.69 9.6 6.5 0.79 9.4 6.5 1.2 1 0 0 1 1 1 0 Connexin EIIBC-GUT_N PF03612.14 EFC36175.1 - 3.1 7.5 7.2 4.4 7.0 7.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 EFC36175.1 - 5 5.8 7.8 5.8 5.6 7.8 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 EFC36175.1 - 5.8 6.4 10.5 7.2 6.1 10.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Atrophin-1 PF03154.15 EFC36175.1 - 7.3 4.7 9.7 8.8 4.5 9.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family YqfQ PF14181.6 EFC36175.1 - 8.7 6.5 11.4 13 5.9 11.4 1.2 1 0 0 1 1 1 0 YqfQ-like protein YabA PF06156.13 EFC36175.1 - 9.8 6.9 20.0 3.7e+02 1.8 20.0 2.3 1 1 0 1 1 1 0 Initiation control protein YabA 3Beta_HSD PF01073.19 EFC36176.1 - 4.1e-10 39.1 0.7 2.8e-07 29.8 0.1 2.3 1 1 1 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NST1 PF13945.6 EFC36176.1 - 0.013 15.6 2.2 0.023 14.8 2.2 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF1700 PF08006.11 EFC36177.1 - 0.0077 15.8 0.7 0.018 14.6 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1700) REJ PF02010.15 EFC36178.1 - 5e-16 58.5 20.6 7.3e-14 51.4 11.7 3.4 2 1 1 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC36178.1 - 1.2e-10 41.6 120.6 3.2e-05 24.2 8.8 9.8 8 1 0 8 8 8 5 EGF-like domain DUF3494 PF11999.8 EFC36178.1 - 0.0023 17.6 8.3 0.0088 15.7 0.8 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3494) Laminin_EGF PF00053.24 EFC36178.1 - 0.036 14.2 0.4 0.036 14.2 0.4 7.7 5 2 3 8 8 8 0 Laminin EGF domain Cnd1 PF12717.7 EFC36179.1 - 0.0054 16.8 3.1 0.0077 16.3 0.7 2.5 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFC36179.1 - 0.0098 16.1 0.0 0.099 12.9 0.0 2.8 2 0 0 2 2 2 1 HEAT repeat Imm9 PF15587.6 EFC36179.1 - 0.057 13.1 4.4 8.6 6.0 0.1 3.7 3 0 0 3 3 3 0 Immunity protein 9 Vac14_Fab1_bd PF12755.7 EFC36179.1 - 0.059 14.0 3.1 0.12 13.0 0.3 3.0 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFC36179.1 - 0.061 13.8 0.0 0.22 12.1 0.0 2.0 1 0 0 1 1 1 0 HEAT-like repeat ACP53EA PF06313.11 EFC36179.1 - 0.084 13.1 1.8 2.2 8.6 0.0 3.4 3 0 0 3 3 3 0 Drosophila ACP53EA protein HEAT_2 PF13646.6 EFC36179.1 - 0.087 13.2 0.0 0.44 11.0 0.0 2.2 2 0 0 2 2 2 0 HEAT repeats TypeIII_RM_meth PF12564.8 EFC36179.1 - 9.9 6.4 10.4 3.3 7.9 0.5 4.1 3 1 1 4 4 4 0 Type III restriction/modification enzyme methylation subunit GWT1 PF06423.12 EFC36180.1 - 6.5e-05 23.1 0.2 0.018 15.2 0.0 2.2 2 0 0 2 2 2 2 GWT1 MFS_1 PF07690.16 EFC36180.1 - 0.00051 19.1 0.2 0.34 9.8 0.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily SUR7 PF06687.12 EFC36180.1 - 0.0023 17.6 0.4 0.28 10.8 0.1 2.2 2 0 0 2 2 2 2 SUR7/PalI family BPD_transp_1 PF00528.22 EFC36180.1 - 0.0025 17.6 5.9 0.07 12.9 0.4 2.3 2 0 0 2 2 2 2 Binding-protein-dependent transport system inner membrane component CrgA PF06781.12 EFC36180.1 - 0.0025 17.8 0.6 0.21 11.7 0.1 2.7 2 0 0 2 2 2 1 Cell division protein CrgA Otopetrin PF03189.13 EFC36180.1 - 0.0053 15.6 0.2 0.039 12.8 0.0 2.0 2 0 0 2 2 2 1 Otopetrin Colicin_V PF02674.16 EFC36180.1 - 0.0069 16.4 9.5 0.24 11.4 1.0 2.1 2 0 0 2 2 2 2 Colicin V production protein SARAF PF06682.12 EFC36180.1 - 0.02 14.5 6.8 4.9 6.7 4.8 3.4 1 1 2 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Orf78 PF06024.12 EFC36180.1 - 0.19 12.0 0.0 0.19 12.0 0.0 3.7 4 0 0 4 4 4 0 Orf78 (ac78) PspB PF06667.12 EFC36180.1 - 0.35 11.0 0.1 0.35 11.0 0.1 3.2 4 0 0 4 4 3 0 Phage shock protein B DUF3671 PF12420.8 EFC36180.1 - 0.57 10.3 6.1 9.9 6.3 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF3755 PF12579.8 EFC36181.1 - 0.0074 15.9 3.3 0.016 14.8 3.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3755) DUF489 PF04356.12 EFC36181.1 - 0.011 15.8 1.5 0.017 15.1 1.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF489) Muted PF14942.6 EFC36181.1 - 0.016 15.6 3.5 0.021 15.2 3.5 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein PilJ PF13675.6 EFC36181.1 - 0.066 13.2 1.0 0.079 13.0 1.0 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term LPP20 PF02169.16 EFC36181.1 - 0.27 11.6 4.6 0.49 10.8 4.6 1.5 1 1 0 1 1 1 0 LPP20 lipoprotein DUF948 PF06103.11 EFC36181.1 - 2.7 8.3 6.4 6.1 7.2 4.2 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) adh_short PF00106.25 EFC36182.1 - 1.8e-30 105.8 0.3 9.3e-27 93.7 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36182.1 - 4.8e-15 55.7 0.0 2.7e-14 53.3 0.0 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC36182.1 - 5e-10 39.6 0.1 8.8e-10 38.8 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC36182.1 - 0.0002 20.9 0.0 0.00028 20.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC36182.1 - 0.0015 18.0 0.0 0.0027 17.2 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC36182.1 - 0.0021 17.2 0.0 0.0031 16.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFC36182.1 - 0.0028 17.6 0.0 0.0051 16.7 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 EFC36182.1 - 0.0082 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ADH_zinc_N PF00107.26 EFC36182.1 - 0.13 12.2 0.2 0.46 10.5 0.2 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase YPEB PF14620.6 EFC36182.1 - 0.13 11.6 0.1 3.9 6.7 0.0 2.2 2 0 0 2 2 2 0 YpeB sporulation HAMP PF00672.25 EFC36184.1 - 2.6e-06 27.7 0.0 6.4e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 HAMP domain CHASE4 PF05228.13 EFC36184.1 - 1.1e-05 25.6 0.1 2.3e-05 24.6 0.1 1.6 1 0 0 1 1 1 1 CHASE4 domain RGS PF00615.19 EFC36184.1 - 0.011 16.0 1.6 0.011 16.0 1.6 2.9 3 1 0 3 3 3 0 Regulator of G protein signaling domain AI-2E_transport PF01594.16 EFC36184.1 - 0.027 13.6 3.8 0.051 12.7 0.4 2.5 2 0 0 2 2 2 0 AI-2E family transporter TMEM132D_C PF15706.5 EFC36184.1 - 0.076 12.8 0.0 0.26 11.1 0.0 1.9 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Tetraspanin PF00335.20 EFC36184.1 - 0.17 11.6 6.3 1.9 8.2 0.2 2.6 3 0 0 3 3 3 0 Tetraspanin family Snapin_Pallidin PF14712.6 EFC36184.1 - 0.19 12.2 7.0 1.7 9.1 0.5 3.1 2 0 0 2 2 2 0 Snapin/Pallidin HemY_N PF07219.13 EFC36184.1 - 1.4 9.2 5.5 9.6 6.5 0.5 2.4 2 0 0 2 2 2 0 HemY protein N-terminus DHHC PF01529.20 EFC36184.1 - 1.8 8.7 6.6 1.4 9.0 1.5 2.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase Orf78 PF06024.12 EFC36184.1 - 5.5 7.3 9.4 0.58 10.5 0.4 3.3 3 0 0 3 3 3 0 Orf78 (ac78) DUF724 PF05266.14 EFC36184.1 - 7.4 6.3 10.6 0.22 11.3 1.4 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF724) Ras PF00071.22 EFC36185.1 - 1.2e-10 41.3 0.0 0.00017 21.2 0.0 3.5 3 0 0 3 3 3 3 Ras family LBP_BPI_CETP_C PF02886.17 EFC36186.1 - 1.6e-35 122.7 0.2 7.1e-34 117.3 0.0 2.3 2 0 0 2 2 2 2 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EFC36186.1 - 3.3e-10 39.8 1.1 1e-09 38.2 0.2 2.1 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain Exo_endo_phos PF03372.23 EFC36187.1 - 0.0074 15.8 0.7 0.011 15.3 0.7 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Aldo_ket_red PF00248.21 EFC36188.1 - 1.6e-47 162.1 0.0 4.3e-46 157.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Hist_deacetyl PF00850.19 EFC36189.1 - 5.7e-90 301.9 0.0 9e-90 301.3 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain NosD PF05048.13 EFC36189.1 - 7.9e-38 130.1 64.8 1.3e-12 47.5 10.9 5.0 2 1 4 6 6 6 4 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 EFC36189.1 - 7.7e-37 126.6 63.8 2.9e-17 62.9 12.7 5.8 2 1 2 5 5 5 4 Right handed beta helix region BRCT PF00533.26 EFC36189.1 - 1.2e-19 70.4 0.6 2.4e-09 37.4 0.0 3.3 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFC36189.1 - 1.6e-18 66.4 0.3 5.2e-13 48.7 0.1 2.7 2 0 0 2 2 2 2 twin BRCT domain BRCT_2 PF16589.5 EFC36189.1 - 4e-10 40.0 0.0 0.00032 21.0 0.0 3.4 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFC36189.1 - 1.1e-05 25.7 0.3 0.035 14.4 0.0 3.3 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 EFC36189.1 - 3.9e-05 23.5 0.0 0.00023 21.0 0.0 2.3 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain Tropomyosin_1 PF12718.7 EFC36190.1 - 0.0041 17.3 8.6 0.0073 16.5 8.6 1.5 1 0 0 1 1 1 1 Tropomyosin like DUF1664 PF07889.12 EFC36190.1 - 0.0086 16.1 6.6 0.015 15.4 6.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 EFC36190.1 - 0.04 14.4 2.5 0.04 14.4 2.5 2.5 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein RNR_N PF08343.10 EFC36190.1 - 0.17 11.9 2.7 9.4 6.3 0.1 3.0 1 1 2 3 3 3 0 Ribonucleotide reductase N-terminal CLZ PF16526.5 EFC36190.1 - 0.21 12.0 4.0 4.8 7.6 0.9 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CdvA PF18822.1 EFC36190.1 - 0.22 11.4 10.1 3.2 7.6 10.1 2.2 1 1 0 1 1 1 0 CdvA-like coiled-coil domain DUF3213 PF11491.8 EFC36190.1 - 0.48 10.6 4.8 0.24 11.6 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3213) Vac_Fusion PF02346.16 EFC36190.1 - 0.57 9.9 6.5 2.8 7.6 0.1 3.4 2 1 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 TORC_N PF12884.7 EFC36190.1 - 1.3 9.8 7.4 0.61 10.9 3.8 2.3 2 1 0 2 2 2 0 Transducer of regulated CREB activity, N terminus Snapin_Pallidin PF14712.6 EFC36190.1 - 1.5 9.3 13.3 1.1 9.8 5.2 3.5 2 1 2 4 4 4 0 Snapin/Pallidin XhlA PF10779.9 EFC36190.1 - 2 8.7 8.1 4.1 7.7 1.8 2.6 2 1 0 2 2 2 0 Haemolysin XhlA EMC3_TMCO1 PF01956.16 EFC36190.1 - 2.9 7.6 7.8 0.82 9.4 4.4 1.8 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Osmo_CC PF08946.10 EFC36190.1 - 3.6 7.9 7.0 22 5.4 1.1 2.7 2 1 0 2 2 2 0 Osmosensory transporter coiled coil ABC_tran_CTD PF16326.5 EFC36190.1 - 6.7 7.0 10.6 2.5 8.4 4.4 2.7 1 1 2 3 3 3 0 ABC transporter C-terminal domain SBP_bac_3 PF00497.20 EFC36191.1 - 0.00022 20.8 0.0 0.0025 17.3 0.0 2.2 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 MTP18 PF10558.9 EFC36191.1 - 0.053 13.5 0.0 0.09 12.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) zf-PARP PF00645.18 EFC36191.1 - 0.079 13.8 0.0 0.27 12.1 0.0 1.8 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region NHL PF01436.21 EFC36192.1 - 1.8e-34 116.0 2.2 6.9e-05 22.7 0.0 7.0 6 0 0 6 6 6 6 NHL repeat BTB PF00651.31 EFC36192.1 - 2.8e-11 43.6 8.0 6.1e-11 42.5 1.3 2.5 2 0 0 2 2 2 1 BTB/POZ domain SGL PF08450.12 EFC36192.1 - 0.00011 21.9 0.5 6.1 6.3 0.0 4.4 2 2 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region AA_kinase PF00696.28 EFC36192.1 - 0.00022 20.9 5.1 0.77 9.3 0.0 4.9 1 1 3 5 5 5 1 Amino acid kinase family DUF2092 PF09865.9 EFC36192.1 - 0.0055 16.1 0.3 19 4.5 0.0 4.1 2 1 3 5 5 5 1 Predicted periplasmic protein (DUF2092) Phytase-like PF13449.6 EFC36192.1 - 0.021 14.8 0.1 1.8 8.4 0.0 3.6 3 1 0 3 3 3 0 Esterase-like activity of phytase TRL PF13146.6 EFC36192.1 - 0.029 14.6 12.7 20 5.5 0.1 6.0 6 0 0 6 6 6 0 TRL-like protein family DUF5485 PF17586.2 EFC36192.1 - 0.084 13.2 0.0 94 3.4 0.0 4.1 4 0 0 4 4 4 0 Family of unknown function (DUF5485) NPH-II PF12011.8 EFC36192.1 - 0.41 10.5 6.0 9.4 6.1 0.1 4.6 2 2 3 6 6 6 0 RNA helicase NPH-II DEAD PF00270.29 EFC36193.1 - 4.6e-31 107.9 0.0 1.6e-30 106.1 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC36193.1 - 2.5e-21 76.1 2.5 3.8e-21 75.5 0.0 2.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain MCR_alpha PF02249.17 EFC36193.1 - 0.02 15.3 0.4 0.064 13.7 0.4 1.8 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain PhoLip_ATPase_C PF16212.5 EFC36194.1 - 2.7e-55 187.8 20.0 6.2e-55 186.7 20.0 1.6 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EFC36194.1 - 4e-12 46.9 0.0 3.2e-08 34.1 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC36194.1 - 4.5e-10 39.5 0.2 5.3e-09 36.1 0.1 2.7 2 1 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFC36194.1 - 2.5e-09 36.9 0.1 2.6e-07 30.4 0.0 2.6 2 0 0 2 2 2 1 E1-E2 ATPase PhoLip_ATPase_N PF16209.5 EFC36194.1 - 0.00051 19.7 0.1 0.00051 19.7 0.1 3.2 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase_3 PF08282.12 EFC36194.1 - 0.0027 17.5 5.3 0.0077 16.0 0.1 3.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase TMEM156 PF15106.6 EFC36195.1 - 0.0042 16.5 4.5 0.0042 16.5 4.5 1.6 1 1 0 1 1 1 1 TMEM156 protein family GREB1 PF15782.5 EFC36195.1 - 5.4 4.0 20.1 6.7 3.7 20.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_M60 PF13402.6 EFC36196.1 - 0.018 14.6 0.6 0.018 14.6 0.6 2.2 2 1 1 3 3 3 0 Peptidase M60, enhancin and enhancin-like FidL_like PF15941.5 EFC36196.1 - 0.078 13.4 0.9 0.28 11.7 0.6 2.0 2 0 0 2 2 2 0 FidL-like putative membrane protein WD40 PF00400.32 EFC36197.1 - 2.6e-05 24.9 2.7 0.29 12.1 0.0 3.5 2 1 0 2 2 2 2 WD domain, G-beta repeat Beach PF02138.18 EFC36198.1 - 1e-118 395.7 1.0 1e-118 395.7 1.0 2.5 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 EFC36198.1 - 6.9e-21 74.2 0.1 6.9e-21 74.2 0.1 3.8 5 0 0 5 5 5 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EFC36198.1 - 0.0098 16.7 1.5 0.27 12.2 0.2 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Arc_trans_TRASH PF08394.10 EFC36198.1 - 0.29 11.5 2.4 1.7 9.0 0.5 2.8 2 0 0 2 2 2 0 Archaeal TRASH domain NAD_binding_2 PF03446.15 EFC36199.1 - 1.9e-35 122.3 0.5 4.3e-35 121.2 0.6 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFC36199.1 - 2.9e-34 117.9 0.0 6.8e-34 116.7 0.0 1.6 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EFC36199.1 - 1.3e-05 25.7 0.0 4.2e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 EFC36199.1 - 0.00088 20.1 0.0 0.0018 19.1 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold 2-Hacid_dh_C PF02826.19 EFC36199.1 - 0.0033 16.8 0.0 0.0062 15.9 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain OAF PF14941.6 EFC36199.1 - 0.0041 16.6 0.6 0.0064 16.0 0.6 1.3 1 0 0 1 1 1 1 Transcriptional regulator, Out at first 3HCDH_N PF02737.18 EFC36199.1 - 0.027 14.4 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Transketolase_C PF02780.20 EFC36199.1 - 0.12 12.2 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain STT3 PF02516.14 EFC36200.1 - 5e-125 418.2 44.8 5.4e-120 401.6 40.4 2.0 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit CrgA PF06781.12 EFC36200.1 - 0.067 13.2 0.8 0.73 9.9 0.1 2.8 2 0 0 2 2 2 0 Cell division protein CrgA F-box PF00646.33 EFC36201.1 - 1.1e-05 25.2 0.1 3.9e-05 23.4 0.1 2.0 1 0 0 1 1 1 1 F-box domain DUF1430 PF07242.11 EFC36201.1 - 0.23 11.7 3.5 0.4 11.0 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1430) LRR_6 PF13516.6 EFC36202.1 - 6.2e-11 41.4 0.3 0.46 10.7 0.0 7.0 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 EFC36202.1 - 0.017 15.5 3.3 0.94 10.0 0.0 4.3 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) DUF724 PF05266.14 EFC36202.1 - 0.054 13.3 0.0 0.2 11.5 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) YjcQ PF09639.10 EFC36202.1 - 0.12 12.6 1.0 0.91 9.8 0.2 2.7 2 2 1 3 3 3 0 YjcQ protein Acetyltransf_1 PF00583.25 EFC36203.1 - 2e-11 44.2 0.2 5e-11 42.9 0.2 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC36203.1 - 1.3e-08 34.9 0.4 3e-08 33.7 0.4 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC36203.1 - 1.6e-06 28.4 0.5 5e-06 26.9 0.4 2.0 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC36203.1 - 0.0013 18.8 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase DUF4586 PF15239.6 EFC36203.1 - 0.082 13.1 0.2 0.095 12.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4586) FAD-oxidase_C PF02913.19 EFC36203.1 - 0.099 12.3 0.0 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 FAD linked oxidases, C-terminal domain TPR_10 PF13374.6 EFC36203.1 - 0.11 12.4 0.0 9.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TLD PF07534.16 EFC36204.1 - 1.8e-30 106.0 0.1 2.9e-29 102.1 0.1 2.6 2 1 0 2 2 2 1 TLD ThuA PF06283.11 EFC36204.1 - 0.041 14.1 1.0 0.13 12.5 1.0 1.8 1 0 0 1 1 1 0 Trehalose utilisation U79_P34 PF03064.16 EFC36204.1 - 0.67 9.3 11.6 0.047 13.1 6.1 1.8 2 0 0 2 2 2 0 HSV U79 / HCMV P34 Flu_M1_C PF08289.11 EFC36204.1 - 2.6 8.3 9.6 1.7 8.9 0.2 2.9 3 0 0 3 3 3 0 Influenza Matrix protein (M1) C-terminal domain TrmO PF01980.16 EFC36205.1 - 1.7e-37 128.3 0.0 3.5e-37 127.2 0.0 1.6 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 EFC36205.1 - 1.6e-05 24.9 0.0 3.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 TrmO C-terminal domain DUF2924 PF11149.8 EFC36206.1 - 2.9 8.3 7.5 0.31 11.4 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) UQ_con PF00179.26 EFC36207.1 - 1.9e-43 147.5 0.1 2.5e-43 147.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC36207.1 - 0.15 12.3 3.4 0.53 10.6 3.4 2.1 1 1 0 1 1 1 0 RWD domain CbtB PF09489.10 EFC36208.1 - 0.075 13.1 2.3 0.12 12.6 1.7 1.6 1 1 0 1 1 1 0 Probable cobalt transporter subunit (CbtB) FA_desaturase PF00487.24 EFC36209.1 - 0.001 19.0 4.2 0.0012 18.7 4.2 1.1 1 0 0 1 1 1 1 Fatty acid desaturase DUF5125 PF17163.4 EFC36210.1 - 0.069 13.3 1.1 5.7 7.1 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5125) Pkinase PF00069.25 EFC36211.1 - 7.6e-27 94.3 2.2 1.7e-26 93.2 2.2 1.5 1 0 0 1 1 1 1 Protein kinase domain DUF4116 PF13475.6 EFC36211.1 - 4.6e-23 80.7 2.7 1.3e-08 34.4 0.0 4.4 3 0 0 3 3 3 3 Domain of unknown function (DUF4116) Pkinase_Tyr PF07714.17 EFC36211.1 - 4.7e-19 68.7 0.1 1e-18 67.6 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC36211.1 - 0.0017 18.3 0.0 0.048 13.6 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC36211.1 - 0.006 15.4 0.0 0.024 13.4 0.0 2.0 1 1 1 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC36211.1 - 0.026 13.9 0.0 0.06 12.7 0.0 1.6 1 0 0 1 1 1 0 Kinase-like COesterase PF00135.28 EFC36212.1 - 9.7e-28 97.3 1.0 1.1e-27 97.1 0.1 1.5 1 1 1 2 2 2 1 Carboxylesterase family Peptidase_S49_N PF08496.10 EFC36212.1 - 0.014 15.5 0.4 0.018 15.1 0.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4834 PF16118.5 EFC36212.1 - 0.034 15.1 1.8 0.067 14.2 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) AI-2E_transport PF01594.16 EFC36212.1 - 0.085 12.0 3.9 0.11 11.6 3.9 1.1 1 0 0 1 1 1 0 AI-2E family transporter SIT PF15330.6 EFC36212.1 - 0.091 13.2 1.9 0.17 12.3 1.9 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Calc_CGRP_IAPP PF00214.19 EFC36212.1 - 0.13 12.7 0.3 0.18 12.1 0.3 1.3 1 0 0 1 1 1 0 Calcitonin / CGRP / IAPP family DUF4446 PF14584.6 EFC36212.1 - 0.27 11.2 3.4 0.4 10.6 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Ras PF00071.22 EFC36213.1 - 9.2e-24 83.9 0.0 1.3e-23 83.4 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36213.1 - 1.3e-12 48.0 0.2 9e-12 45.3 0.0 2.4 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC36213.1 - 7.7e-05 22.2 0.1 0.00011 21.7 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family LAG1-DNAbind PF09271.11 EFC36213.1 - 0.17 12.5 3.0 1.9 9.1 0.6 2.3 2 1 0 2 2 2 0 LAG1, DNA binding Cyclin_N PF00134.23 EFC36215.1 - 4.7e-45 152.4 2.5 5.5e-44 149.0 0.5 2.8 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC36215.1 - 4.3e-21 75.2 2.6 4.3e-21 75.2 2.6 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain RNA_pol_A_bac PF01000.26 EFC36216.1 - 1.2e-30 106.2 0.2 3.9e-30 104.5 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFC36216.1 - 1.5e-19 69.2 0.0 3.7e-19 67.9 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4 PF00037.27 EFC36216.1 - 0.047 13.5 1.3 0.047 13.5 1.3 2.4 3 0 0 3 3 3 0 4Fe-4S binding domain tRNA-synt_1g PF09334.11 EFC36216.1 - 2.1 7.0 6.6 3.6 6.2 2.2 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (M) HAD_SAK_1 PF10307.9 EFC36218.1 - 0.039 13.8 0.7 0.068 13.0 0.7 1.4 1 0 0 1 1 1 0 HAD domain family 1 in Swiss Army Knife RNA repair proteins PRC2_HTH_1 PF18118.1 EFC36218.1 - 0.12 13.2 0.0 0.36 11.7 0.0 1.8 1 1 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Isochorismatase PF00857.20 EFC36219.1 - 2.7e-32 112.3 0.2 4.3e-32 111.7 0.2 1.3 1 1 0 1 1 1 1 Isochorismatase family Zot PF05707.12 EFC36219.1 - 0.028 14.1 0.1 0.048 13.3 0.1 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) Ank_2 PF12796.7 EFC36220.1 - 2.5e-08 34.4 0.1 5.3e-08 33.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC36220.1 - 3.8e-07 30.5 0.2 4.8e-05 23.8 0.0 2.6 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC36220.1 - 2.1e-05 24.6 1.9 0.00027 21.2 0.1 3.0 2 1 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 EFC36220.1 - 2.1e-05 24.7 0.4 8.5e-05 22.8 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFC36220.1 - 0.002 18.5 0.3 0.023 15.2 0.0 2.6 2 1 0 2 2 2 1 Ankyrin repeat Ribosomal_L1 PF00687.21 EFC36221.1 - 6.4e-41 140.3 6.8 7.6e-41 140.1 6.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3430 PF11912.8 EFC36222.1 - 3.1e-05 24.1 18.3 3.4e-05 24.0 11.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3430) Furin-like PF00757.20 EFC36222.1 - 0.0084 16.0 8.7 0.017 15.0 8.7 1.6 1 1 0 1 1 1 1 Furin-like cysteine rich region GF_recep_IV PF14843.6 EFC36222.1 - 0.015 15.1 2.5 0.015 15.1 2.5 2.2 1 1 1 2 2 2 0 Growth factor receptor domain IV DUF2116 PF09889.9 EFC36222.1 - 0.027 14.5 1.2 0.14 12.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Peptidase_C97 PF05903.14 EFC36223.1 - 0.0051 16.6 0.2 0.0051 16.6 0.2 2.2 2 0 0 2 2 2 1 PPPDE putative peptidase domain Hid1 PF12722.7 EFC36224.1 - 8.2e-135 450.9 29.6 1.6e-89 301.1 23.4 5.1 1 1 4 5 5 5 3 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 EFC36224.1 - 9.4e-123 410.8 18.3 2.2e-108 363.4 14.3 2.1 2 0 0 2 2 2 2 Dyggve-Melchior-Clausen syndrome protein HTH_Tnp_Tc5 PF03221.16 EFC36224.1 - 0.11 12.6 0.1 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain FixP_N PF14715.6 EFC36225.1 - 0.57 10.0 3.2 0.34 10.7 0.4 2.2 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP DUF2254 PF10011.9 EFC36225.1 - 0.62 8.8 4.8 1.4 7.7 1.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) RGS PF00615.19 EFC36226.1 - 4e-09 36.8 0.5 9.7e-09 35.5 0.5 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Guanylate_cyc PF00211.20 EFC36226.1 - 2.5e-05 24.0 0.1 6.1e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain GPS PF01825.21 EFC36226.1 - 0.0018 18.7 1.1 0.0042 17.6 1.1 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif CENP-F_C_Rb_bdg PF10490.9 EFC36226.1 - 0.19 11.2 0.0 0.42 10.1 0.0 1.5 1 0 0 1 1 1 0 Rb-binding domain of kinetochore protein Cenp-F/LEK1 DUF2371 PF10177.9 EFC36226.1 - 2.7 8.2 5.4 3.5 7.8 0.6 3.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) Pkinase PF00069.25 EFC36227.1 - 5.9e-09 35.7 0.1 1.2e-06 28.1 0.1 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36227.1 - 0.015 14.6 0.1 0.27 10.5 0.0 2.3 1 1 1 2 2 2 0 Protein tyrosine kinase KAR PF15222.6 EFC36227.1 - 0.022 15.0 0.4 0.47 10.8 0.1 2.4 2 0 0 2 2 2 0 Kidney androgen-regulated Kinase-like PF14531.6 EFC36227.1 - 0.05 12.9 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF3420 PF11900.8 EFC36229.1 - 0.068 13.3 0.2 0.28 11.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3420) Apolipoprotein PF01442.18 EFC36230.1 - 1.5e-06 28.3 3.0 1.9e-06 27.9 3.0 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EFC36230.1 - 6.5e-06 26.2 5.5 0.00027 21.0 0.8 1.9 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus Mitofilin PF09731.9 EFC36230.1 - 2.9e-05 23.2 9.7 3.2e-05 23.0 9.7 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein PIN_8 PF18476.1 EFC36230.1 - 0.0002 21.3 7.6 0.00031 20.7 7.6 1.3 1 0 0 1 1 1 1 PIN like domain Aha1_N PF09229.11 EFC36230.1 - 0.00063 20.0 11.8 0.099 12.9 5.2 2.7 1 1 1 2 2 2 2 Activator of Hsp90 ATPase, N-terminal DUF1640 PF07798.11 EFC36230.1 - 0.0021 18.1 16.9 0.018 15.1 16.9 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1640) dCache_2 PF08269.11 EFC36230.1 - 0.0023 17.1 5.6 0.0029 16.8 5.6 1.2 1 0 0 1 1 1 1 Cache domain DUF4407 PF14362.6 EFC36230.1 - 0.005 16.2 5.5 0.0075 15.7 5.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) YtxH PF12732.7 EFC36230.1 - 0.0053 17.3 13.4 0.12 12.9 8.3 2.3 1 1 1 2 2 2 2 YtxH-like protein RNase_J_C PF17770.1 EFC36230.1 - 0.0054 17.8 9.0 0.039 15.0 0.9 2.7 1 1 1 2 2 2 1 Ribonuclease J C-terminal domain ATP-synt_B PF00430.18 EFC36230.1 - 0.0055 16.8 4.3 0.093 12.8 1.6 2.1 1 1 1 2 2 2 1 ATP synthase B/B' CF(0) Prominin PF05478.11 EFC36230.1 - 0.0086 14.1 9.0 0.01 13.9 9.0 1.1 1 0 0 1 1 1 1 Prominin Fzo_mitofusin PF04799.13 EFC36230.1 - 0.013 15.0 10.1 0.073 12.6 6.8 2.1 1 1 1 2 2 2 0 fzo-like conserved region HTH_40 PF14493.6 EFC36230.1 - 0.015 15.7 7.6 0.16 12.5 1.0 2.3 1 1 1 2 2 2 0 Helix-turn-helix domain Brr6_like_C_C PF10104.9 EFC36230.1 - 0.017 14.9 8.2 0.43 10.4 0.3 2.9 1 1 2 3 3 3 0 Di-sulfide bridge nucleocytoplasmic transport domain DUF445 PF04286.12 EFC36230.1 - 0.017 14.9 7.6 0.021 14.7 7.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Bcr-Abl_Oligo PF09036.10 EFC36230.1 - 0.018 15.1 10.1 2.4 8.2 0.7 3.2 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Mt_ATP-synt_B PF05405.14 EFC36230.1 - 0.02 14.5 10.4 0.049 13.3 10.5 1.6 1 1 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) MbeB_N PF04837.12 EFC36230.1 - 0.02 15.2 8.3 2 8.8 2.6 3.3 1 1 2 3 3 3 0 MbeB-like, N-term conserved region Exonuc_VII_L PF02601.15 EFC36230.1 - 0.02 14.4 4.6 0.023 14.3 4.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Z1 PF10593.9 EFC36230.1 - 0.022 14.3 6.5 0.04 13.4 6.5 1.5 1 1 0 1 1 1 0 Z1 domain DUF1664 PF07889.12 EFC36230.1 - 0.025 14.6 7.6 0.093 12.8 7.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HSCB_C PF07743.13 EFC36230.1 - 0.032 14.7 13.3 0.11 13.0 7.2 2.9 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain PKK PF12474.8 EFC36230.1 - 0.035 14.2 21.8 0.4 10.8 20.5 2.2 1 1 0 1 1 1 0 Polo kinase kinase Syntaxin-6_N PF09177.11 EFC36230.1 - 0.04 14.5 7.3 0.4 11.3 3.8 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Phage_Mu_Gam PF07352.12 EFC36230.1 - 0.042 13.8 13.3 0.57 10.1 0.8 2.4 1 1 2 3 3 3 0 Bacteriophage Mu Gam like protein Peptidase_M2 PF01401.18 EFC36230.1 - 0.043 12.4 5.1 0.049 12.2 5.1 1.1 1 0 0 1 1 1 0 Angiotensin-converting enzyme DUF2115 PF09888.9 EFC36230.1 - 0.044 14.3 7.6 0.058 13.9 7.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) DUF883 PF05957.13 EFC36230.1 - 0.05 14.2 3.7 0.55 10.9 1.9 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF668 PF05003.12 EFC36230.1 - 0.052 14.0 1.9 5.5 7.5 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF668) DUF4854 PF16146.5 EFC36230.1 - 0.054 13.8 7.0 0.55 10.6 0.3 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4854) Bacillus_HBL PF05791.11 EFC36230.1 - 0.07 13.0 10.3 0.19 11.5 10.3 1.7 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) 5_3_exonuc_N PF02739.16 EFC36230.1 - 0.078 12.9 3.3 0.36 10.7 0.5 2.1 1 1 1 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain DUF5063 PF16702.5 EFC36230.1 - 0.08 13.3 2.0 0.26 11.7 2.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5063) DUF1837 PF08878.11 EFC36230.1 - 0.085 12.6 13.4 0.044 13.6 4.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1837) Band_7 PF01145.25 EFC36230.1 - 0.086 12.8 3.6 0.56 10.2 3.8 2.4 1 1 0 1 1 1 0 SPFH domain / Band 7 family GreA_GreB_N PF03449.15 EFC36230.1 - 0.089 13.0 7.4 1.7 8.8 1.0 2.7 1 1 2 3 3 2 0 Transcription elongation factor, N-terminal AAA_11 PF13086.6 EFC36230.1 - 0.097 12.4 5.7 0.1 12.4 5.7 1.1 1 0 0 1 1 1 0 AAA domain YojJ PF10372.9 EFC36230.1 - 0.11 12.7 17.4 12 6.1 1.0 4.4 1 1 2 3 3 3 0 Bacterial membrane-spanning protein N-terminus THOC7 PF05615.13 EFC36230.1 - 0.12 12.7 10.8 0.27 11.5 10.8 1.7 1 1 0 1 1 1 0 Tho complex subunit 7 ATPase PF06745.13 EFC36230.1 - 0.13 11.5 6.4 0.18 11.1 5.3 1.6 1 1 1 2 2 2 0 KaiC HlyD_2 PF12700.7 EFC36230.1 - 0.17 10.6 13.8 0.19 10.4 13.8 1.1 1 0 0 1 1 1 0 HlyD family secretion protein HSP70 PF00012.20 EFC36230.1 - 0.17 10.1 7.9 0.19 9.9 7.9 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF1269 PF06897.12 EFC36230.1 - 0.17 12.2 1.7 0.46 10.8 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1269) RGS PF00615.19 EFC36230.1 - 0.19 12.0 10.3 4.2 7.7 10.2 2.1 1 1 1 2 2 2 0 Regulator of G protein signaling domain RRF PF01765.19 EFC36230.1 - 0.21 11.5 12.9 1.1 9.1 12.9 2.1 1 1 0 1 1 1 0 Ribosome recycling factor SICA_alpha PF12887.7 EFC36230.1 - 0.21 11.4 15.8 3.6 7.4 1.7 2.8 1 1 1 2 2 2 0 SICA extracellular alpha domain DUF4337 PF14235.6 EFC36230.1 - 0.21 11.7 6.4 0.27 11.4 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) IMD PF08397.11 EFC36230.1 - 0.22 10.9 14.3 0.27 10.6 14.2 1.2 1 1 0 1 1 1 0 IRSp53/MIM homology domain PSD4 PF07631.11 EFC36230.1 - 0.23 12.0 3.6 2.5 8.6 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) P35 PF02331.15 EFC36230.1 - 0.24 10.7 9.1 0.36 10.1 1.6 2.0 1 1 1 2 2 2 0 Apoptosis preventing protein PilJ PF13675.6 EFC36230.1 - 0.25 11.4 0.8 1.1 9.4 0.7 2.0 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term SpoIIID PF12116.8 EFC36230.1 - 0.26 11.4 2.2 1.5 8.9 0.4 2.5 1 1 2 3 3 3 0 Stage III sporulation protein D Nop25 PF09805.9 EFC36230.1 - 0.27 11.7 14.5 3 8.3 6.0 2.0 1 1 1 2 2 2 0 Nucleolar protein 12 (25kDa) Annexin PF00191.20 EFC36230.1 - 0.32 11.1 10.5 3.5 7.8 1.4 3.8 1 1 2 3 3 3 0 Annexin HYLS1_C PF15311.6 EFC36230.1 - 0.36 11.6 3.6 11 6.9 0.5 2.3 1 1 1 2 2 2 0 Hydrolethalus syndrome protein 1 C-terminus FliT PF05400.13 EFC36230.1 - 0.37 11.6 7.5 4 8.3 2.0 2.4 2 1 0 2 2 2 0 Flagellar protein FliT SASP PF00269.20 EFC36230.1 - 0.4 10.7 7.4 5.2 7.2 0.2 3.1 1 1 1 2 2 2 0 Small, acid-soluble spore proteins, alpha/beta type ZnuA PF01297.17 EFC36230.1 - 0.4 10.0 5.5 1.9 7.8 1.4 2.2 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic V-SNARE PF05008.15 EFC36230.1 - 0.41 11.0 12.2 1.5 9.2 11.8 2.4 1 1 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus CCDC74_C PF14917.6 EFC36230.1 - 0.46 11.0 8.1 8.8 6.9 0.6 2.7 1 1 1 2 2 2 0 Coiled coil protein 74, C terminal Focal_AT PF03623.13 EFC36230.1 - 0.47 10.4 7.4 2 8.4 0.3 2.3 1 1 1 2 2 2 0 Focal adhesion targeting region T3SS_needle_F PF09392.10 EFC36230.1 - 0.5 10.6 4.9 13 6.1 0.2 2.8 1 1 2 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF 7TMR-HDED PF07697.11 EFC36230.1 - 0.5 10.4 8.1 0.84 9.7 8.1 1.4 1 1 0 1 1 1 0 7TM-HD extracellular DUF3502 PF12010.8 EFC36230.1 - 0.58 10.8 7.1 3.9 8.1 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3502) DUF3763 PF12592.8 EFC36230.1 - 0.65 10.1 9.0 0.99 9.5 0.9 3.2 2 1 0 3 3 3 0 Protein of unknown function (DUF3763) RB_A PF01858.17 EFC36230.1 - 0.65 9.8 8.8 0.39 10.5 4.5 1.9 1 1 1 2 2 2 0 Retinoblastoma-associated protein A domain Cas_DxTHG PF09455.10 EFC36230.1 - 0.78 9.3 9.0 0.91 9.0 9.0 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family CsgF PF10614.9 EFC36230.1 - 0.81 9.9 7.0 1.2 9.4 2.8 2.0 1 1 1 2 2 2 0 Type VIII secretion system (T8SS), CsgF protein FapA PF03961.13 EFC36230.1 - 0.87 8.1 10.9 1 7.9 10.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 EFC36230.1 - 1 8.6 9.4 1.3 8.2 9.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein PHA_gran_rgn PF09650.10 EFC36230.1 - 1.1 9.6 6.3 27 5.1 0.2 3.3 1 1 1 3 3 3 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) DUF1722 PF08349.11 EFC36230.1 - 1.3 9.4 8.2 58 4.0 7.7 3.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1722) PNPase PF03726.14 EFC36230.1 - 1.3 9.5 9.8 6.1 7.4 2.5 2.3 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain ResIII PF04851.15 EFC36230.1 - 1.6 8.7 9.8 7.1 6.6 9.8 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit OmpH PF03938.14 EFC36230.1 - 1.7 8.9 17.5 2.5 8.5 17.2 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) EAP30 PF04157.16 EFC36230.1 - 2.1 7.6 8.5 35 3.6 7.9 2.4 1 1 1 2 2 2 0 EAP30/Vps36 family TA0956 PF11513.8 EFC36230.1 - 2.2 8.6 9.1 1.2 9.4 0.8 3.2 1 1 1 3 3 2 0 Thermoplasma acidophilum protein TA0956 Bac_RepA_C PF18008.1 EFC36230.1 - 2.2 8.7 8.0 2.6 8.4 2.8 2.3 1 1 1 2 2 2 0 Replication initiator protein A C-terminal domain PdaC PF13739.6 EFC36230.1 - 2.3 9.2 14.3 9.5e+02 0.9 14.3 2.4 1 1 0 1 1 1 0 Deacetylase PdaC DUF3810 PF12725.7 EFC36230.1 - 2.4 7.4 5.4 4.3 6.6 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) DUF16 PF01519.16 EFC36230.1 - 2.4 8.7 16.9 0.45 11.0 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 Spore_II_R PF09551.10 EFC36230.1 - 2.6 8.5 7.9 3.4 8.2 4.5 1.9 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) AbiH PF14253.6 EFC36230.1 - 2.7 7.8 11.9 5.1 6.9 11.9 1.5 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH CelTOS PF18659.1 EFC36230.1 - 3.2 8.2 10.3 9.9 6.6 10.4 1.8 1 1 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites eIF-4B PF06273.11 EFC36230.1 - 3.8 6.5 11.2 4.4 6.3 11.2 1.0 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Pet100 PF09803.9 EFC36230.1 - 4.2 8.0 12.0 3e+03 -1.2 12.0 2.8 1 1 0 1 1 0 0 Pet100 OTU PF02338.19 EFC36230.1 - 4.4 7.8 6.0 12 6.4 0.8 2.2 1 1 1 2 2 2 0 OTU-like cysteine protease Arc_PepC_II PF06847.11 EFC36230.1 - 4.6 7.8 8.1 4e+02 1.6 8.1 2.6 1 1 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II AKNA PF12443.8 EFC36230.1 - 4.9 7.9 14.3 15 6.3 2.8 2.8 1 1 1 2 2 2 0 AT-hook-containing transcription factor Dynein_light PF01221.18 EFC36230.1 - 5 7.5 11.5 1.2e+03 -0.1 11.4 3.2 1 1 0 1 1 1 0 Dynein light chain type 1 Toxin_trans PF07952.12 EFC36230.1 - 6 5.9 11.7 4.3 6.3 1.4 1.9 1 1 1 2 2 2 0 Clostridium neurotoxin, Translocation domain VASP_tetra PF08776.11 EFC36230.1 - 8.6 6.0 30.9 0.19 11.3 1.3 5.0 3 1 3 6 6 4 0 VASP tetramerisation domain Uteroglobin PF01099.17 EFC36230.1 - 9.5 6.6 13.2 3.7 8.0 5.5 2.3 1 1 1 2 2 2 0 Uteroglobin family TPR_2 PF07719.17 EFC36231.1 - 3.2e-11 42.4 13.8 0.00039 20.3 0.6 7.1 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC36231.1 - 2.6e-10 39.7 5.0 0.0065 16.6 0.3 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36231.1 - 3.3e-09 36.2 9.1 0.0026 17.5 0.9 6.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC36231.1 - 9e-09 34.9 3.5 0.0013 18.3 0.4 4.9 5 0 0 5 5 5 2 TPR repeat TPR_12 PF13424.6 EFC36231.1 - 8e-07 29.3 5.2 0.021 15.1 0.3 4.7 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC36231.1 - 0.00017 22.1 1.8 5.1 7.7 0.1 5.0 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC36231.1 - 0.00025 21.6 0.0 72 4.6 0.0 5.8 5 3 1 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC36231.1 - 0.00042 20.5 1.5 0.93 10.0 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC36231.1 - 0.00073 20.1 0.6 0.39 11.4 0.0 3.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC36231.1 - 0.016 15.4 0.1 11 6.2 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1524 PF07510.11 EFC36231.1 - 0.018 14.9 0.5 0.82 9.5 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1524) FAT PF02259.23 EFC36231.1 - 0.021 14.1 6.2 0.035 13.3 6.2 1.5 1 0 0 1 1 1 0 FAT domain TPR_10 PF13374.6 EFC36231.1 - 0.037 13.9 1.1 6.7 6.7 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFC36231.1 - 0.043 13.8 2.7 0.13 12.3 0.1 2.8 3 0 0 3 3 3 0 Mad3/BUB1 homology region 1 Sel1 PF08238.12 EFC36231.1 - 0.046 14.4 1.0 0.61 10.9 0.1 3.1 3 0 0 3 3 3 0 Sel1 repeat ANAPC3 PF12895.7 EFC36231.1 - 2.4 8.5 11.0 18 5.6 0.0 4.6 4 1 2 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 AT_hook PF02178.19 EFC36232.1 - 1.7 8.8 11.9 0.21 11.6 6.8 2.2 2 0 0 2 2 2 0 AT hook motif DIOX_N PF14226.6 EFC36233.1 - 1.5e-23 83.8 0.0 3.4e-23 82.6 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFC36233.1 - 1.9e-23 82.9 0.0 3.2e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RGS PF00615.19 EFC36234.1 - 2.7e-07 30.9 4.3 9.2e-07 29.1 4.3 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain PLD_C PF12357.8 EFC36235.1 - 1.4e-16 60.1 0.0 3.2e-16 59.0 0.0 1.6 1 0 0 1 1 1 1 Phospholipase D C terminal PLDc PF00614.22 EFC36235.1 - 2.7e-15 55.8 0.1 1.8e-06 27.9 0.0 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFC36235.1 - 8.4e-11 41.9 0.1 2.3e-06 27.5 0.0 3.5 3 0 0 3 3 3 2 PLD-like domain DUF999 PF06198.11 EFC36235.1 - 7.3 6.6 8.6 20 5.2 8.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF999) MACPF PF01823.19 EFC36236.1 - 7.8e-10 39.2 0.0 1.6e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 MAC/Perforin domain NHL PF01436.21 EFC36237.1 - 1.7e-26 90.9 11.9 1e-05 25.3 0.1 7.2 7 0 0 7 7 7 5 NHL repeat ANAPC4_WD40 PF12894.7 EFC36237.1 - 3.6e-05 24.0 0.2 3.4 8.0 0.0 4.2 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain SGL PF08450.12 EFC36237.1 - 0.00054 19.6 0.1 0.33 10.5 0.0 3.4 2 2 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Endonuclease_7 PF02945.15 EFC36237.1 - 0.041 13.8 0.1 0.082 12.8 0.1 1.5 1 0 0 1 1 1 0 Recombination endonuclease VII Arylesterase PF01731.20 EFC36237.1 - 0.07 13.3 0.1 33 4.8 0.0 3.4 3 1 1 4 4 4 0 Arylesterase UQ_con PF00179.26 EFC36239.1 - 1.2e-24 86.6 0.2 1.6e-24 86.1 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC36239.1 - 0.01 16.1 0.2 0.015 15.6 0.2 1.3 1 0 0 1 1 1 0 RWD domain Ank_2 PF12796.7 EFC36240.1 - 4.9e-08 33.4 2.3 4.7e-05 23.9 0.0 4.4 4 1 0 4 4 4 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC36240.1 - 5.2e-07 29.8 0.6 5.5e-05 23.4 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC36240.1 - 1.1e-05 25.4 0.6 5.2 8.0 0.0 5.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EFC36240.1 - 1.3e-05 25.6 3.2 0.048 14.3 0.2 5.0 5 2 2 7 7 7 2 Ankyrin repeats (many copies) DUF3677 PF12432.8 EFC36240.1 - 0.066 13.5 0.1 0.27 11.6 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) Mif2_N PF15624.6 EFC36240.1 - 3.1 8.5 9.0 0.081 13.6 2.4 1.7 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal RGS PF00615.19 EFC36241.1 - 6.1e-18 65.2 2.3 2.1e-17 63.4 0.5 2.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain CHASE4 PF05228.13 EFC36241.1 - 3.4e-09 37.1 0.1 7.3e-09 36.0 0.1 1.6 1 0 0 1 1 1 1 CHASE4 domain HAMP PF00672.25 EFC36241.1 - 1.5e-05 25.3 0.0 5.2e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 HAMP domain Holin_BlyA PF05102.12 EFC36241.1 - 0.49 10.4 3.4 2.2 8.3 3.4 2.1 1 0 0 1 1 1 0 holin, BlyA family Guanylate_cyc PF00211.20 EFC36244.1 - 7.5e-48 162.6 0.0 2e-47 161.2 0.0 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RGS PF00615.19 EFC36244.1 - 2.9e-08 34.0 4.6 2.9e-08 34.0 4.6 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain HNOBA PF07701.14 EFC36244.1 - 0.0047 16.4 0.3 0.011 15.2 0.3 1.6 1 0 0 1 1 1 1 Heme NO binding associated PAS_9 PF13426.7 EFC36244.1 - 0.015 15.6 0.0 0.081 13.2 0.0 2.3 2 0 0 2 2 2 0 PAS domain CCD PF07860.11 EFC36244.1 - 0.038 14.0 0.9 0.093 12.8 0.2 2.0 2 0 0 2 2 2 0 WisP family C-Terminal Region DUF5393 PF17371.2 EFC36244.1 - 0.15 10.1 0.0 0.25 9.4 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) DUF2523 PF10734.9 EFC36244.1 - 0.26 11.9 3.7 1.9 9.1 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2523) PAS PF00989.25 EFC36245.1 - 7.3e-10 38.8 0.0 2.7e-09 37.0 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EFC36245.1 - 9.1e-08 32.3 0.6 3.6e-07 30.4 0.1 2.3 2 1 0 2 2 2 1 PAS domain PH PF00169.29 EFC36245.1 - 0.00013 22.5 0.4 0.00074 20.0 0.0 2.5 2 1 0 2 2 2 1 PH domain RGS PF00615.19 EFC36245.1 - 0.0032 17.7 3.7 0.0054 17.0 0.1 2.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain PAS_8 PF13188.7 EFC36245.1 - 0.008 16.2 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 PAS domain CENP-F_leu_zip PF10473.9 EFC36245.1 - 0.086 12.9 8.5 0.25 11.4 8.2 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NYN PF01936.18 EFC36245.1 - 0.089 13.3 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 NYN domain PAS_4 PF08448.10 EFC36245.1 - 0.11 12.7 0.6 0.49 10.7 0.0 2.1 2 0 0 2 2 2 0 PAS fold SelP_N PF04592.14 EFC36245.1 - 3.9 6.8 14.4 1.9 7.8 11.7 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Hol_Tox PF16935.5 EFC36246.1 - 0.21 11.6 0.5 0.61 10.2 0.5 1.7 1 0 0 1 1 1 0 Putative Holin-like Toxin (Hol-Tox) DUF4131 PF13567.6 EFC36246.1 - 0.43 10.2 2.9 0.78 9.4 2.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) YdjM PF04307.14 EFC36247.1 - 1.5e-06 27.7 3.6 2.6e-06 26.9 3.6 1.4 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase Ceramidase PF05875.12 EFC36247.1 - 0.013 14.9 1.1 0.023 14.1 0.2 1.8 2 0 0 2 2 2 0 Ceramidase Claudin_2 PF13903.6 EFC36247.1 - 0.038 13.8 0.5 0.55 10.0 0.0 2.1 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4184 PF13803.6 EFC36247.1 - 0.081 12.6 3.6 3.2 7.4 3.6 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4184) COX1 PF00115.20 EFC36247.1 - 0.32 9.8 7.4 1.9 7.2 7.3 1.9 1 1 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I DPM3 PF08285.11 EFC36247.1 - 1.5 9.1 0.0 1.5 9.1 0.0 2.9 4 0 0 4 4 4 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) FtsH_ext PF06480.15 EFC36248.1 - 0.034 14.5 0.0 0.9 9.9 0.0 2.2 2 0 0 2 2 2 0 FtsH Extracellular COQ7 PF03232.13 EFC36248.1 - 0.098 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 UB2H PF14814.6 EFC36249.1 - 0.003 17.6 0.5 0.012 15.6 0.0 2.3 2 0 0 2 2 2 1 Bifunctional transglycosylase second domain CHAP PF05257.16 EFC36249.1 - 0.15 12.6 1.0 0.28 11.8 0.1 1.9 2 0 0 2 2 2 0 CHAP domain SOG2 PF10428.9 EFC36249.1 - 1.7 7.8 32.2 2 7.5 32.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 EFC36249.1 - 4.2 7.3 18.8 5.1 7.0 18.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rax2 PF12768.7 EFC36250.1 - 0.022 14.2 0.2 0.034 13.6 0.2 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity EGF_2 PF07974.13 EFC36250.1 - 1 9.8 15.5 0.068 13.6 10.5 1.5 2 0 0 2 2 2 0 EGF-like domain EGF PF00008.27 EFC36250.1 - 5.8 7.3 11.0 12 6.3 11.0 1.6 1 0 0 1 1 1 0 EGF-like domain DUF3006 PF11213.8 EFC36251.1 - 0.099 12.9 0.8 0.38 11.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3006) DUF1447 PF07288.11 EFC36251.1 - 0.64 10.1 4.7 0.86 9.7 0.0 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF1447) Claudin_2 PF13903.6 EFC36252.1 - 0.007 16.1 0.5 2.9 7.6 0.1 2.2 2 0 0 2 2 2 2 PMP-22/EMP/MP20/Claudin tight junction DUF2207 PF09972.9 EFC36252.1 - 0.67 8.6 2.5 1.1 8.0 2.5 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MRAP PF15183.6 EFC36252.1 - 5.2 7.1 6.6 18 5.3 1.9 2.3 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Phage_holin_3_6 PF07332.11 EFC36252.1 - 6.9 6.8 9.9 5.9 7.0 5.3 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III MCD PF05292.11 EFC36253.1 - 1.4e-77 260.8 0.1 4.9e-77 259.0 0.1 1.9 1 1 0 1 1 1 1 Malonyl-CoA decarboxylase C-terminal domain MCD_N PF17408.2 EFC36253.1 - 3.3e-06 27.1 0.7 4.2e-05 23.6 0.2 2.9 2 1 0 2 2 2 1 Malonyl-CoA decarboxylase N-terminal domain DUF4652 PF15525.6 EFC36253.1 - 0.0035 17.2 2.7 0.0061 16.4 2.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4652) SIX1_SD PF16878.5 EFC36253.1 - 0.0082 16.7 2.4 3.1 8.4 0.0 2.8 2 0 0 2 2 2 2 Transcriptional regulator, SIX1, N-terminal SD domain DUF3993 PF13158.6 EFC36253.1 - 0.081 13.1 0.7 11 6.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) DUF441 PF04284.13 EFC36253.1 - 0.2 11.6 1.3 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF441) FRB_dom PF08771.11 EFC36253.1 - 1.8 9.0 5.2 5.3 7.5 1.2 3.1 2 1 1 3 3 3 0 FKBP12-rapamycin binding domain SF-assemblin PF06705.11 EFC36253.1 - 7.8 5.8 7.2 5.4 6.3 2.0 2.2 2 0 0 2 2 2 0 SF-assemblin/beta giardin AOX PF01786.17 EFC36254.1 - 6.4e-51 173.0 1.0 9.1e-51 172.5 1.0 1.2 1 0 0 1 1 1 1 Alternative oxidase YrzK PF17449.2 EFC36254.1 - 0.097 13.0 0.8 5 7.5 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized YrzK-like Citrate_synt PF00285.21 EFC36255.1 - 1.3e-136 455.4 0.0 1.6e-136 455.1 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain ABC_membrane_2 PF06472.15 EFC36256.1 - 1.3e-64 218.3 4.6 5e-63 213.0 5.9 2.1 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFC36256.1 - 4.2e-20 72.7 0.0 1e-19 71.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 EFC36256.1 - 0.0011 18.5 0.0 0.0027 17.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_23 PF13476.6 EFC36256.1 - 0.0035 17.9 5.3 0.039 14.5 0.2 2.8 3 0 0 3 3 3 1 AAA domain AAA_21 PF13304.6 EFC36256.1 - 0.015 15.1 1.1 0.06 13.2 0.1 2.4 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC36256.1 - 0.015 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 EFC36256.1 - 0.025 14.3 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFC36256.1 - 0.076 12.3 0.1 0.63 9.3 0.0 2.3 3 0 0 3 3 3 0 Zeta toxin AAA_27 PF13514.6 EFC36256.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 EFC36256.1 - 0.12 11.7 0.1 0.23 10.8 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family UDPG_MGDP_dh_N PF03721.14 EFC36256.1 - 0.16 11.5 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Peptidase_S10 PF00450.22 EFC36257.1 - 1.7e-20 73.8 0.6 2.1e-20 73.6 0.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase TMEM107 PF14995.6 EFC36257.1 - 0.071 13.5 0.1 0.15 12.5 0.1 1.5 1 1 0 1 1 1 0 Transmembrane protein Pkinase PF00069.25 EFC36258.1 - 6.5e-40 137.1 0.8 3.4e-33 115.1 0.3 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36258.1 - 2.7e-29 102.3 0.0 9.7e-21 74.2 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EFC36258.1 - 8.3e-07 28.6 0.0 8.3e-07 28.6 0.0 4.1 5 0 0 5 5 5 1 Kinase-like IQ PF00612.27 EFC36258.1 - 0.00025 20.5 0.2 0.00083 18.9 0.2 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif Kdo PF06293.14 EFC36258.1 - 0.0047 16.3 0.0 0.53 9.6 0.0 3.0 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF924 PF06041.11 EFC36259.1 - 5.2e-50 170.1 0.3 7.2e-50 169.6 0.3 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) DUF2255 PF10012.9 EFC36259.1 - 0.15 12.2 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) Abhydrolase_6 PF12697.7 EFC36262.1 - 0.00057 20.5 0.0 0.00077 20.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC36262.1 - 0.00079 19.1 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC36262.1 - 0.03 13.6 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Pox_LP_H2 PF03356.15 EFC36262.1 - 0.056 13.3 0.0 0.24 11.2 0.0 1.9 1 1 0 2 2 2 0 Viral late protein H2 Abhydrolase_1 PF00561.20 EFC36263.1 - 0.00058 19.6 0.2 0.0016 18.1 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC36263.1 - 0.001 19.7 0.0 0.0037 17.9 0.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC36263.1 - 0.0026 17.1 0.0 0.0084 15.4 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 BTB PF00651.31 EFC36264.1 - 2.2e-22 79.4 1.1 1.5e-10 41.3 0.2 2.5 2 0 0 2 2 2 2 BTB/POZ domain Kelch_4 PF13418.6 EFC36264.1 - 1.8e-19 69.5 3.2 3e-07 30.3 0.0 5.8 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC36264.1 - 1.4e-15 56.9 3.1 0.00018 21.4 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EFC36264.1 - 1.7e-15 56.7 7.1 4.6e-07 29.9 0.0 5.7 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFC36264.1 - 1.2e-14 53.6 5.3 4.8e-05 22.8 0.0 5.0 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFC36264.1 - 9.8e-13 48.0 0.6 4.8e-06 26.7 0.0 4.7 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC36264.1 - 2.1e-07 30.6 6.5 0.0017 18.2 0.0 4.6 5 0 0 5 5 5 2 Kelch motif LodA_N PF17990.1 EFC36264.1 - 0.0014 18.6 2.2 0.0026 17.7 2.2 1.4 1 0 0 1 1 1 1 L-Lysine epsilon oxidase N-terminal BACK PF07707.15 EFC36264.1 - 0.14 12.3 5.6 0.38 10.9 0.1 3.7 4 0 0 4 4 4 0 BTB And C-terminal Kelch DAO PF01266.24 EFC36265.1 - 1.3e-42 146.7 0.0 1.6e-42 146.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC36265.1 - 0.0021 18.3 0.4 0.0059 16.8 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain YafQ_toxin PF15738.5 EFC36265.1 - 0.02 15.2 0.4 0.11 12.8 0.1 2.2 2 0 0 2 2 2 0 Bacterial toxin of type II toxin-antitoxin system, YafQ Guanylate_cyc PF00211.20 EFC36266.1 - 4.1e-25 88.5 0.0 9.3e-25 87.3 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC36266.1 - 2e-10 40.8 0.4 1.1e-09 38.5 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC36266.1 - 6.5e-06 26.1 0.0 1.8e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC36266.1 - 0.0022 18.2 0.0 0.0053 17.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC36266.1 - 0.025 14.0 0.3 0.025 14.0 0.3 2.2 2 0 0 2 2 2 0 Heme NO binding associated CUE PF02845.16 EFC36266.1 - 0.064 13.0 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 CUE domain Peptidase_S9 PF00326.21 EFC36266.1 - 0.079 12.4 0.0 7.8 5.9 0.0 2.5 2 0 0 2 2 2 0 Prolyl oligopeptidase family BAAT_C PF08840.11 EFC36266.1 - 0.088 12.7 0.3 0.46 10.4 0.0 2.4 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal TFIIS_M PF07500.14 EFC36266.1 - 0.37 11.3 6.5 0.044 14.3 0.7 2.5 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS), central domain LRR_8 PF13855.6 EFC36267.1 - 3.6e-31 106.7 66.0 1.7e-06 27.7 5.4 6.4 2 2 7 9 9 9 9 Leucine rich repeat LRR_6 PF13516.6 EFC36267.1 - 5.4e-31 104.0 53.1 0.00043 20.1 0.3 12.4 13 0 0 13 13 13 10 Leucine Rich repeat LRR_4 PF12799.7 EFC36267.1 - 3e-20 72.0 46.2 0.00013 22.3 6.8 8.3 2 2 8 11 11 11 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC36267.1 - 1.8e-06 27.6 14.3 0.036 13.6 0.1 4.3 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EFC36267.1 - 5.6e-05 23.1 33.4 0.92 10.3 0.0 10.7 10 3 0 10 10 10 2 Leucine Rich Repeat LRR_3 PF07725.12 EFC36267.1 - 2.2 8.3 5.3 0.69 9.9 0.2 3.1 3 0 0 3 3 3 0 Leucine Rich Repeat DUF4809 PF16067.5 EFC36268.1 - 0.025 14.8 1.2 4.6 7.4 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4809) RNase_T PF00929.24 EFC36269.1 - 6.8e-06 26.7 0.8 4.7e-05 24.0 0.7 2.4 1 1 0 1 1 1 1 Exonuclease zf-Di19 PF05605.12 EFC36269.1 - 0.00057 20.1 0.1 0.0019 18.4 0.1 1.9 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding DUF5051 PF16473.5 EFC36269.1 - 0.016 15.2 0.3 0.04 13.9 0.1 1.9 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like zf-C2H2_4 PF13894.6 EFC36269.1 - 0.032 15.1 0.1 0.032 15.1 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFC36269.1 - 0.33 11.5 0.1 0.33 11.5 0.1 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Trypan_PARP PF05887.11 EFC36270.1 - 9e-08 32.2 164.1 0.026 14.5 37.3 4.9 1 1 4 5 5 5 4 Procyclic acidic repetitive protein (PARP) DUF966 PF06136.13 EFC36270.1 - 1.3 8.7 12.6 1.6 8.4 12.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) PQ-loop PF04193.14 EFC36272.1 - 0.022 14.5 0.3 0.022 14.5 0.3 1.8 2 0 0 2 2 2 0 PQ loop repeat PIRT PF15099.6 EFC36272.1 - 0.16 11.6 2.4 0.17 11.5 0.5 2.0 2 1 0 2 2 2 0 Phosphoinositide-interacting protein family CRAL_TRIO PF00650.20 EFC36273.1 - 4.6e-19 68.7 0.1 1.1e-18 67.5 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain EF-hand_7 PF13499.6 EFC36274.1 - 3.8e-23 81.7 9.2 9.9e-12 45.1 1.6 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC36274.1 - 8.7e-23 78.1 4.3 3.6e-05 23.0 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EFC36274.1 - 2.3e-20 70.7 3.3 0.00024 20.8 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFC36274.1 - 9.6e-17 60.6 4.9 1.3e-05 24.9 0.0 3.5 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EFC36274.1 - 1.5e-15 55.8 1.7 0.0011 18.3 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.6 EFC36274.1 - 1.9e-07 30.8 1.2 0.00019 21.3 0.0 3.4 3 1 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EFC36274.1 - 0.004 17.5 2.2 3.8 7.9 0.5 3.1 2 2 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC36274.1 - 0.026 14.5 1.9 0.17 11.9 0.5 2.3 2 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand MecA_N PF05223.11 EFC36274.1 - 0.034 14.4 1.1 0.067 13.5 0.1 1.9 2 1 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain IFN-gamma PF00714.17 EFC36274.1 - 0.08 12.8 2.8 0.34 10.8 0.1 2.2 2 0 0 2 2 2 0 Interferon gamma DUF3404 PF11884.8 EFC36275.1 - 0.093 11.9 0.4 0.15 11.2 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) adh_short PF00106.25 EFC36276.1 - 1.8e-51 174.4 0.7 2.3e-51 174.1 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36276.1 - 2.6e-37 128.6 0.4 3.3e-37 128.3 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC36276.1 - 4e-11 43.1 0.2 5.6e-11 42.7 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC36276.1 - 2.9e-05 23.6 0.2 4.3e-05 23.1 0.2 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC36276.1 - 0.00073 18.8 0.7 0.00097 18.4 0.7 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFC36276.1 - 0.022 14.6 0.3 0.04 13.8 0.3 1.5 1 1 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFC36276.1 - 0.029 13.8 0.1 0.054 12.9 0.1 1.6 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Exo_endo_phos PF03372.23 EFC36277.1 - 0.00081 19.0 0.0 0.0024 17.5 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFC36277.1 - 0.057 13.3 0.1 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase PAS PF00989.25 EFC36278.1 - 5.2e-08 32.9 0.0 3.4e-07 30.3 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC36278.1 - 1.2e-06 28.3 0.0 3.2e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EFC36278.1 - 0.00097 19.4 0.1 0.0047 17.2 0.1 2.2 2 0 0 2 2 2 1 PAS domain DUF1059 PF06348.11 EFC36278.1 - 0.091 13.0 0.1 0.33 11.2 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1059) Spore_III_AF PF09581.10 EFC36278.1 - 0.11 12.5 0.0 0.11 12.5 0.0 3.6 4 0 0 4 4 4 0 Stage III sporulation protein AF (Spore_III_AF) PAS_4 PF08448.10 EFC36278.1 - 0.16 12.3 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 PAS fold ABC_tran PF00005.27 EFC36278.1 - 6.3 7.3 6.8 1.4 9.4 1.0 3.0 3 0 0 3 3 3 0 ABC transporter TAP_C PF03943.13 EFC36280.1 - 4.7e-16 58.2 0.5 9.8e-11 41.1 0.2 3.3 2 1 1 3 3 3 3 TAP C-terminal domain UBA_4 PF14555.6 EFC36280.1 - 1.9e-06 27.6 1.3 0.14 12.0 0.3 3.4 3 0 0 3 3 3 2 UBA-like domain DUF1110 PF06533.12 EFC36280.1 - 0.049 13.6 0.1 0.075 13.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1110) Peptidase_M56 PF05569.11 EFC36281.1 - 0.00054 19.2 0.2 0.0033 16.7 0.0 1.9 2 0 0 2 2 2 1 BlaR1 peptidase M56 Orf78 PF06024.12 EFC36281.1 - 0.0047 17.2 3.7 0.016 15.5 0.5 2.3 2 1 0 2 2 2 1 Orf78 (ac78) Nodulin-like PF06813.13 EFC36281.1 - 0.0082 15.7 4.0 0.056 12.9 0.4 2.2 2 0 0 2 2 2 1 Nodulin-like Ctr PF04145.15 EFC36281.1 - 0.045 14.4 1.3 0.095 13.3 1.3 1.5 1 1 0 1 1 1 0 Ctr copper transporter family DUF2207 PF09972.9 EFC36281.1 - 0.076 11.8 0.0 0.11 11.2 0.0 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) CD34_antigen PF06365.12 EFC36281.1 - 0.083 12.5 0.3 1.8 8.1 0.1 2.1 2 0 0 2 2 2 0 CD34/Podocalyxin family Phage_holin_3_6 PF07332.11 EFC36281.1 - 0.14 12.2 1.5 3.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2663 PF10864.8 EFC36281.1 - 0.25 11.8 1.8 1.8 9.0 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) DUF4064 PF13273.6 EFC36281.1 - 0.33 11.3 5.0 0.62 10.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Sigma_reg_N PF13800.6 EFC36281.1 - 0.35 11.2 3.5 11 6.4 0.5 2.7 2 1 1 3 3 3 0 Sigma factor regulator N-terminal SBP_bac_3 PF00497.20 EFC36282.1 - 5.2e-13 48.9 0.0 7.6e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ABC2_membrane PF01061.24 EFC36283.1 - 2.5e-21 76.1 20.7 2.5e-21 76.1 20.7 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EFC36283.1 - 5.3e-15 56.1 0.0 5.3e-15 56.1 0.0 2.3 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 EFC36283.1 - 0.018 14.8 0.4 0.049 13.4 0.4 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EFC36283.1 - 0.027 14.0 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC36283.1 - 0.049 14.2 0.0 0.049 14.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFC36283.1 - 0.049 14.1 0.1 0.049 14.1 0.1 3.3 3 1 0 3 3 3 0 AAA domain PDR_CDR PF06422.12 EFC36283.1 - 6.2 6.8 6.6 0.72 9.8 0.5 2.6 3 0 0 3 3 3 0 CDR ABC transporter DUF4241 PF14025.6 EFC36284.1 - 4.6e-29 102.0 1.6 5.5e-29 101.8 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4241) RCC1_2 PF13540.6 EFC36286.1 - 4.5e-29 99.6 23.4 3.1e-07 30.0 0.2 5.5 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC36286.1 - 1.7e-21 76.6 4.3 9.1e-05 23.0 0.0 6.8 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat LRR_6 PF13516.6 EFC36287.1 - 7e-34 113.0 27.5 0.0041 17.0 0.1 11.9 12 0 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC36287.1 - 1.4e-25 88.8 27.7 1.6e-07 31.0 0.1 6.6 4 2 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC36287.1 - 1.3e-20 73.1 43.3 6.1e-05 23.3 1.0 9.4 2 1 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36287.1 - 2.8e-13 48.4 18.0 4.5 8.2 0.2 11.5 12 0 0 12 12 12 5 Leucine Rich Repeat RCC1_2 PF13540.6 EFC36289.1 - 0.097 12.5 0.0 0.79 9.6 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat DUF5500 PF17604.2 EFC36289.1 - 0.15 12.2 0.2 0.7 10.0 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5500) Erf4 PF10256.9 EFC36290.1 - 5.2e-05 23.3 0.2 0.0001 22.4 0.2 1.6 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family MerC PF03203.14 EFC36290.1 - 0.029 14.8 0.3 0.036 14.5 0.3 1.1 1 0 0 1 1 1 0 MerC mercury resistance protein DUF3624 PF12292.8 EFC36290.1 - 0.93 9.9 3.9 16 6.0 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3624) AF-4 PF05110.13 EFC36291.1 - 0.0038 15.4 18.3 0.0046 15.1 18.3 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Ndc1_Nup PF09531.10 EFC36291.1 - 0.38 9.4 2.2 0.4 9.3 2.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 EFC36291.1 - 4.7 5.9 10.0 6.2 5.5 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MGAT2 PF05060.14 EFC36292.1 - 9.1e-05 21.7 0.1 0.0006 19.0 0.1 2.0 2 0 0 2 2 2 1 N-acetylglucosaminyltransferase II (MGAT2) GNT-I PF03071.15 EFC36292.1 - 0.00014 20.7 0.3 0.00033 19.6 0.3 1.5 1 0 0 1 1 1 1 GNT-I family LBP_BPI_CETP_C PF02886.17 EFC36293.1 - 1.5e-31 109.7 1.4 4.1e-28 98.4 0.0 2.8 2 1 1 3 3 3 2 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EFC36293.1 - 3.2e-11 43.1 0.4 1e-10 41.5 0.4 1.9 1 0 0 1 1 1 1 LBP / BPI / CETP family, N-terminal domain DUF4116 PF13475.6 EFC36294.1 - 9.7e-24 82.8 15.4 3.9e-07 29.7 0.0 8.3 2 2 5 8 8 8 8 Domain of unknown function (DUF4116) HTH_44 PF14641.6 EFC36294.1 - 0.046 14.2 1.0 0.11 12.9 1.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix DNA-binding domain of SPT6 Complex1_LYR PF05347.15 EFC36295.1 - 0.035 14.1 1.1 0.063 13.3 0.4 1.8 1 1 0 1 1 1 0 Complex 1 protein (LYR family) Cir_Bir_Yir PF06022.11 EFC36295.1 - 0.065 12.7 2.5 0.53 9.7 2.5 2.2 1 1 0 1 1 1 0 Plasmodium variant antigen protein Cir/Yir/Bir Ank_2 PF12796.7 EFC36296.1 - 2.9e-25 88.6 1.5 1.5e-12 47.9 0.0 5.1 3 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC36296.1 - 8.2e-22 77.3 9.3 3.4e-07 30.7 0.0 7.6 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC36296.1 - 2.4e-20 70.4 5.9 0.0012 19.1 0.0 8.2 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 EFC36296.1 - 5e-18 64.9 0.9 0.0003 21.0 0.0 7.2 6 1 1 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC36296.1 - 8.4e-18 64.0 2.2 0.00049 20.4 0.1 7.4 6 1 0 6 6 6 3 Ankyrin repeat YkuI_C PF10388.9 EFC36296.1 - 0.046 13.5 1.0 1.2 9.0 1.7 2.5 2 0 0 2 2 2 0 EAL-domain associated signalling protein domain TPR_10 PF13374.6 EFC36296.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat C2 PF00168.30 EFC36297.1 - 2.7e-13 50.1 0.1 1.1e-09 38.5 0.2 2.9 3 0 0 3 3 3 2 C2 domain PRiA4_ORF3 PF07929.11 EFC36298.1 - 6.6e-18 65.0 0.0 6.6e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 Plasmid pRiA4b ORF-3-like protein YL1 PF05764.13 EFC36298.1 - 0.12 12.4 15.5 0.24 11.5 15.5 1.5 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 EFC36298.1 - 0.34 9.1 16.2 0.48 8.6 16.2 1.2 1 0 0 1 1 1 0 Nop14-like family CCG PF02754.16 EFC36298.1 - 0.37 11.0 2.0 0.43 10.8 0.1 2.0 2 1 1 3 3 3 0 Cysteine-rich domain TFIIF_alpha PF05793.12 EFC36298.1 - 1.5 7.3 29.9 2.6 6.5 29.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SGT1 PF07093.11 EFC36298.1 - 2 6.8 16.6 2.8 6.3 16.6 1.2 1 0 0 1 1 1 0 SGT1 protein Pox_RNA_Pol_19 PF05320.12 EFC36298.1 - 4.7 7.1 11.9 9.2 6.2 11.9 1.6 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit RCC1 PF00415.18 EFC36299.1 - 2.8e-25 88.7 5.2 7.3e-08 32.9 0.1 5.6 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC36299.1 - 5.6e-21 73.8 13.7 6.2e-06 25.9 0.2 5.8 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat zf-CCCH_4 PF18044.1 EFC36299.1 - 6.1e-06 25.9 10.5 0.0083 15.9 1.2 2.8 2 1 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 EFC36299.1 - 0.00064 19.6 13.3 0.016 15.1 1.4 3.3 3 1 1 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 EFC36299.1 - 0.016 15.6 8.8 1.1 9.9 1.3 2.9 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger oligo_HPY PF08352.12 EFC36299.1 - 0.022 15.3 0.9 0.51 10.9 0.2 2.5 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region zf_CCCH_4 PF18345.1 EFC36299.1 - 0.2 11.7 20.8 0.08 13.0 2.8 3.5 4 0 0 4 4 4 0 Zinc finger domain DUF5123 PF17161.4 EFC36299.1 - 3.6 8.7 13.0 1.8 9.7 1.3 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF5123) TPR_2 PF07719.17 EFC36300.1 - 0.0017 18.3 0.8 0.0017 18.3 0.8 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36300.1 - 0.015 15.1 2.2 0.03 14.1 0.6 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC36300.1 - 0.033 14.4 1.9 0.25 11.6 0.3 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFC36300.1 - 0.12 12.7 3.0 0.15 12.3 0.3 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC36300.1 - 0.18 12.5 1.3 2.2 9.1 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribosomal_S3Ae PF01015.18 EFC36301.1 - 5.7e-33 114.2 9.2 7.6e-33 113.8 9.2 1.2 1 0 0 1 1 1 1 Ribosomal S3Ae family LBP_BPI_CETP PF01273.25 EFC36301.1 - 0.002 17.7 0.9 0.085 12.5 0.1 2.3 2 0 0 2 2 2 2 LBP / BPI / CETP family, N-terminal domain Cytokin_check_N PF10407.9 EFC36301.1 - 0.029 14.3 0.1 0.067 13.1 0.1 1.6 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus PhoPQ_related PF10142.9 EFC36302.1 - 1.4e-25 89.8 0.1 1.5e-25 89.6 0.1 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DUF736 PF05284.12 EFC36302.1 - 0.04 13.8 0.0 0.052 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF736) Mucin PF01456.17 EFC36303.1 - 0.27 11.2 1.4 0.32 11.0 1.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein TLD PF07534.16 EFC36304.1 - 4.9e-10 39.8 1.5 1.2e-09 38.5 1.5 1.8 1 1 0 1 1 1 1 TLD Ank_2 PF12796.7 EFC36305.1 - 4.7e-24 84.8 1.6 3e-11 43.8 0.7 4.7 3 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC36305.1 - 8.5e-19 65.7 3.0 0.011 16.2 0.2 7.4 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 EFC36305.1 - 2.3e-17 62.8 2.0 0.059 13.7 0.1 6.3 3 2 3 6 6 6 5 Ankyrin repeats (many copies) U-box PF04564.15 EFC36305.1 - 1.2e-16 60.6 0.1 3.2e-16 59.3 0.1 1.8 1 0 0 1 1 1 1 U-box domain Ank_4 PF13637.6 EFC36305.1 - 8.5e-16 58.1 1.3 0.0022 18.5 0.1 5.3 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC36305.1 - 6.1e-13 48.6 0.8 0.00067 20.0 0.3 5.1 5 0 0 5 5 5 2 Ankyrin repeat zf-Nse PF11789.8 EFC36305.1 - 0.0062 16.3 0.0 0.023 14.5 0.0 2.0 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 EFC36305.1 - 0.011 15.9 0.0 0.032 14.4 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein PI3K_P85_iSH2 PF16454.5 EFC36305.1 - 0.042 13.4 1.1 0.14 11.8 1.1 1.9 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RNase_H PF00075.24 EFC36306.1 - 7.1e-14 52.2 0.0 2.3e-13 50.5 0.0 2.0 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EFC36306.1 - 1.4e-05 24.9 0.8 1.4e-05 24.9 0.8 2.5 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase RVT_3 PF13456.6 EFC36306.1 - 0.014 15.2 0.0 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase-like Exo_endo_phos PF03372.23 EFC36306.1 - 0.062 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Activator_LAG-3 PF11498.8 EFC36306.1 - 0.15 11.0 0.0 0.31 9.9 0.0 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 HTH_40 PF14493.6 EFC36306.1 - 3.1 8.3 5.5 33 5.0 0.2 3.8 3 1 1 4 4 4 0 Helix-turn-helix domain Inhibitor_I29 PF08246.12 EFC36307.1 - 0.039 14.4 1.5 12 6.4 1.1 3.3 2 1 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) PAC2 PF09754.9 EFC36308.1 - 5.9e-16 59.1 0.1 7.3e-16 58.8 0.1 1.1 1 0 0 1 1 1 1 PAC2 family FRG1 PF06229.12 EFC36309.1 - 1.4e-31 109.7 0.0 3.6e-09 36.6 0.0 5.3 2 1 4 6 6 6 5 FRG1-like domain Fascin PF06268.13 EFC36309.1 - 1.4e-24 86.5 0.0 5.1e-08 33.1 0.0 4.1 1 1 3 4 4 4 4 Fascin domain EF-hand_7 PF13499.6 EFC36309.1 - 7e-09 36.0 0.1 1.1e-08 35.4 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC36309.1 - 2.6e-06 26.9 0.3 0.02 14.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain DUF569 PF04601.13 EFC36309.1 - 8.5e-06 25.5 0.0 1.3 8.7 0.0 3.7 3 1 1 4 4 4 3 Domain of unknown function (DUF569) EF-hand_1 PF00036.32 EFC36309.1 - 0.00026 20.3 0.1 0.021 14.3 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFC36309.1 - 0.052 13.4 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 EFC36309.1 - 0.18 11.4 0.0 0.44 10.1 0.0 1.6 1 0 0 1 1 1 0 EF hand F-box PF00646.33 EFC36310.1 - 0.0088 15.9 0.0 0.035 14.0 0.0 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC36310.1 - 0.094 12.6 0.0 0.31 10.9 0.0 1.9 1 0 0 1 1 1 0 F-box-like SBP_bac_3 PF00497.20 EFC36311.1 - 4.2e-13 49.2 0.0 6.6e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 RCC1 PF00415.18 EFC36312.1 - 1e-06 29.3 0.4 8.5e-06 26.3 0.0 2.7 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC36312.1 - 0.011 15.5 2.7 0.011 15.5 2.7 4.2 5 0 0 5 5 5 0 Regulator of chromosome condensation (RCC1) repeat Aminoglyc_resit PF10706.9 EFC36312.1 - 0.047 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Aminoglycoside-2''-adenylyltransferase MinC_N PF05209.13 EFC36312.1 - 0.12 12.4 0.1 6.5 6.8 0.0 2.5 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain CENP-B_dimeris PF09026.10 EFC36312.1 - 0.42 11.0 2.4 8.5 6.8 0.0 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TPX2 PF06886.11 EFC36313.1 - 0.07 13.4 3.1 26 5.1 0.1 3.7 3 0 0 3 3 3 0 Targeting protein for Xklp2 (TPX2) DUF4820 PF16091.5 EFC36313.1 - 0.086 12.2 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) AHSP PF09236.10 EFC36313.1 - 0.23 11.9 1.6 1.2 9.7 0.3 2.8 2 1 1 3 3 3 0 Alpha-haemoglobin stabilising protein YcaO_C PF18381.1 EFC36313.1 - 3.8 7.4 6.8 15 5.4 0.7 2.5 2 1 0 2 2 2 0 YcaO cyclodehydratase C-terminal domain G-alpha PF00503.20 EFC36315.1 - 5e-46 157.5 10.3 6.9e-46 157.0 10.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit DNA_ligase_A_M PF01068.21 EFC36317.1 - 4.4e-50 170.2 2.9 7.8e-50 169.3 1.4 2.2 2 0 0 2 2 2 1 ATP dependent DNA ligase domain LIG3_BRCT PF16759.5 EFC36317.1 - 2.2e-27 95.2 0.9 5.7e-24 84.2 0.1 3.0 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 EFC36317.1 - 1.1e-16 60.9 0.5 2e-07 31.3 0.0 2.9 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 EFC36317.1 - 5.8e-13 49.3 0.0 1.6e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EFC36317.1 - 1.1e-10 41.7 2.3 1.9e-05 24.9 0.6 3.1 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 EFC36317.1 - 5.9e-09 36.4 0.6 1.9e-08 34.8 0.6 1.9 1 0 0 1 1 1 1 RNA ligase PTCB-BRCT PF12738.7 EFC36317.1 - 3.8e-06 26.7 0.1 2.5e-05 24.1 0.1 2.4 2 0 0 2 2 2 1 twin BRCT domain mRNA_cap_enzyme PF01331.19 EFC36317.1 - 0.0031 17.4 2.8 0.021 14.7 2.8 2.3 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain BRCT_3 PF18428.1 EFC36317.1 - 0.029 14.5 1.0 0.3 11.2 0.3 2.8 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain TfoX_C PF04994.13 EFC36317.1 - 0.055 13.6 0.1 0.58 10.3 0.1 2.3 2 0 0 2 2 2 0 TfoX C-terminal domain Trans_coact PF16805.5 EFC36317.1 - 0.11 12.6 1.1 0.34 11.0 1.1 1.9 1 0 0 1 1 1 0 Phage late-transcription coactivator Velvet PF11754.8 EFC36317.1 - 0.35 10.8 8.3 2.9 7.8 3.1 2.2 2 0 0 2 2 2 0 Velvet factor DUF913 PF06025.12 EFC36317.1 - 0.87 8.5 20.2 0.35 9.8 2.2 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 EFC36317.1 - 1 7.6 30.9 0.15 10.3 21.6 2.2 2 0 0 2 2 2 0 CDC45-like protein RR_TM4-6 PF06459.12 EFC36317.1 - 2.7 7.7 21.4 4.4 7.1 14.9 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Apt1 PF10351.9 EFC36317.1 - 2.9 6.7 28.1 0.99 8.2 13.4 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Zip PF02535.22 EFC36317.1 - 4.8 6.3 17.6 8.1 5.6 0.4 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Trypan_PARP PF05887.11 EFC36319.1 - 4.7e-06 26.6 83.4 5 7.1 49.2 2.5 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) ERG4_ERG24 PF01222.17 EFC36320.1 - 5.2e-69 233.1 21.8 6.3e-69 232.8 21.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Zn_clus PF00172.18 EFC36321.1 - 4.1e-06 26.8 14.7 7e-06 26.1 14.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Herpes_UL49_2 PF04823.12 EFC36322.1 - 0.4 10.8 5.0 3.9 7.7 0.9 2.2 1 1 1 2 2 2 0 Herpesvirus UL49 tegument protein DUF4743 PF15916.5 EFC36324.1 - 0.084 12.8 0.0 0.13 12.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4743) PIP5K PF01504.18 EFC36325.1 - 1.9e-10 40.4 1.5 2.8e-10 39.9 0.8 1.5 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Lamp PF01299.17 EFC36325.1 - 0.08 12.8 0.5 0.08 12.8 0.5 2.4 3 0 0 3 3 3 0 Lysosome-associated membrane glycoprotein (Lamp) Chromo_2 PF18704.1 EFC36328.1 - 0.079 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Chromatin organization modifier domain 2 Miff PF05644.11 EFC36328.1 - 1.1 8.8 12.6 0.31 10.6 9.5 1.5 1 1 1 2 2 2 0 Mitochondrial and peroxisomal fission factor Mff DUF4116 PF13475.6 EFC36329.1 - 5.4e-95 311.0 29.9 3e-13 49.3 0.1 11.7 9 3 2 11 11 11 11 Domain of unknown function (DUF4116) DBD_HTH PF18430.1 EFC36329.1 - 0.00067 19.4 0.7 3.4 7.5 0.0 4.5 4 0 0 4 4 4 2 Putative DNA-binding domain CbiG_C PF01890.16 EFC36329.1 - 0.00095 19.7 3.7 1.6 9.3 0.0 5.2 5 1 0 6 6 6 1 Cobalamin synthesis G C-terminus ArsR PF09824.9 EFC36329.1 - 1.3 8.6 15.2 3.6 7.2 0.1 4.9 5 0 0 5 5 5 0 ArsR transcriptional regulator Sec1 PF00995.23 EFC36330.1 - 4.7e-107 359.6 8.5 6.1e-107 359.2 8.5 1.1 1 0 0 1 1 1 1 Sec1 family Pur_ac_phosph_N PF16656.5 EFC36330.1 - 4.5e-18 65.6 3.3 1.6e-17 63.8 3.3 2.0 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EFC36330.1 - 1.5e-16 61.5 4.7 4.8e-16 59.9 4.7 1.9 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFC36330.1 - 2.1e-09 38.1 1.1 6.2e-09 36.6 1.1 1.8 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C LexA_DNA_bind PF01726.16 EFC36330.1 - 0.041 13.7 0.3 3.3 7.5 0.0 2.7 3 0 0 3 3 3 0 LexA DNA binding domain Peripla_BP_6 PF13458.6 EFC36331.1 - 4e-29 102.4 0.0 7.9e-16 58.6 0.0 5.0 4 1 0 4 4 4 3 Periplasmic binding protein Guanylate_cyc PF00211.20 EFC36331.1 - 1.1e-18 67.5 0.0 5e-18 65.4 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 EFC36331.1 - 1.3e-16 60.7 4.5 7.8e-08 31.8 0.1 2.8 3 0 0 3 3 3 2 Receptor family ligand binding region Sclerostin PF05463.11 EFC36333.1 - 0.21 11.3 6.1 0.14 11.8 1.9 2.2 2 0 0 2 2 2 0 Sclerostin (SOST) AT_hook PF02178.19 EFC36333.1 - 1.1 9.4 6.5 0.13 12.2 2.1 1.9 2 0 0 2 2 2 0 AT hook motif Snf7 PF03357.21 EFC36334.1 - 1.1e-25 90.2 35.3 1.1e-25 90.2 35.3 1.6 1 1 1 2 2 2 1 Snf7 AlkA_N PF06029.11 EFC36334.1 - 0.14 12.4 0.4 0.31 11.3 0.4 1.5 1 0 0 1 1 1 0 AlkA N-terminal domain Tctex-1 PF03645.13 EFC36334.1 - 0.53 10.5 4.2 4.7 7.5 0.1 2.6 2 1 0 2 2 2 0 Tctex-1 family RNA_pol_Rpb1_4 PF05000.17 EFC36334.1 - 4.1 7.4 9.3 0.4 10.6 0.8 2.8 1 1 0 2 2 2 0 RNA polymerase Rpb1, domain 4 IQ PF00612.27 EFC36335.1 - 2.6e-06 26.7 1.9 4.3e-06 26.0 0.9 2.0 2 0 0 2 2 2 1 IQ calmodulin-binding motif LRR_6 PF13516.6 EFC36336.1 - 8.4e-37 122.1 56.6 0.00017 21.4 0.1 16.2 16 0 0 16 16 16 14 Leucine Rich repeat LRR_8 PF13855.6 EFC36336.1 - 2.8e-21 75.0 46.2 1.9e-05 24.3 5.9 7.7 2 1 9 12 12 12 11 Leucine rich repeat LRR_4 PF12799.7 EFC36336.1 - 9e-19 67.3 54.1 0.0056 17.1 5.7 10.3 2 2 11 13 13 13 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC36336.1 - 3.7e-07 29.8 16.8 0.026 14.0 4.1 4.5 1 1 4 5 5 5 3 Leucine-rich repeat LRR_1 PF00560.33 EFC36336.1 - 4.5e-06 26.5 31.3 8.9 7.3 0.1 12.5 11 2 0 11 11 11 3 Leucine Rich Repeat Ribosomal_L12_N PF16320.5 EFC36336.1 - 1.3 8.8 6.6 18 5.2 0.1 4.2 4 0 0 4 4 4 0 Ribosomal protein L7/L12 dimerisation domain zf-A20 PF01754.16 EFC36337.1 - 1.2e-09 38.0 9.1 2e-09 37.2 9.1 1.4 1 0 0 1 1 1 1 A20-like zinc finger SBP_bac_3 PF00497.20 EFC36338.1 - 1.4e-14 54.1 0.0 2.1e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DUF4116 PF13475.6 EFC36339.1 - 5.7e-43 144.4 17.6 1.4e-15 56.7 0.0 7.1 5 2 3 8 8 8 7 Domain of unknown function (DUF4116) EGF_2 PF07974.13 EFC36341.1 - 4.6e-32 110.1 189.4 9.1e-05 22.7 10.6 13.0 12 0 0 12 12 12 12 EGF-like domain EGF PF00008.27 EFC36341.1 - 0.00013 22.2 138.0 0.023 15.0 4.2 12.9 12 0 0 12 12 12 10 EGF-like domain C2 PF00168.30 EFC36342.1 - 5.7e-15 55.5 0.1 1.4e-14 54.2 0.1 1.7 1 0 0 1 1 1 1 C2 domain PhoD PF09423.10 EFC36342.1 - 1.7e-14 53.7 0.4 1.4e-13 50.6 1.1 1.8 2 0 0 2 2 2 1 PhoD-like phosphatase RCC1_2 PF13540.6 EFC36347.1 - 4.5e-19 67.8 11.8 3.7e-06 26.6 0.0 6.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC36347.1 - 9.7e-13 48.5 9.5 2.6e-08 34.4 0.2 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat MFS_1 PF07690.16 EFC36349.1 - 1.1e-31 110.1 20.3 2.4e-28 99.1 18.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC36349.1 - 2e-06 26.9 11.4 2e-06 26.9 11.4 2.8 2 2 1 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 EFC36349.1 - 3.7e-06 26.0 18.7 0.0059 15.5 4.3 3.1 2 1 1 3 3 3 3 MFS_1 like family CLN3 PF02487.17 EFC36349.1 - 2.2e-05 23.7 0.1 0.00039 19.6 0.0 2.6 3 0 0 3 3 3 1 CLN3 protein MFS_4 PF06779.14 EFC36349.1 - 0.00097 18.5 0.1 0.035 13.4 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 EFC36349.1 - 0.0047 15.4 1.3 0.033 12.6 0.0 2.2 2 0 0 2 2 2 1 Transmembrane secretion effector OAD_gamma PF04277.13 EFC36349.1 - 0.076 13.6 0.7 0.076 13.6 0.7 3.3 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain THOC2_N PF16134.5 EFC36349.1 - 0.64 8.6 6.1 1.2 7.7 5.5 1.6 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus TypeIII_RM_meth PF12564.8 EFC36351.1 - 0.08 13.1 2.8 0.15 12.2 0.2 2.9 3 0 0 3 3 3 0 Type III restriction/modification enzyme methylation subunit Bromo_TP_like PF17027.5 EFC36351.1 - 2.8 8.1 7.6 3.9 7.7 0.7 3.5 3 0 0 3 3 3 0 Histone-fold protein ABC_membrane PF00664.23 EFC36352.1 - 1.6e-54 185.4 13.8 2.2e-54 185.0 13.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC36352.1 - 3.7e-36 124.7 0.0 8.4e-36 123.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC36352.1 - 1.6e-07 31.0 2.0 3.9e-05 23.2 0.0 2.8 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFC36352.1 - 0.00011 22.1 0.1 0.002 17.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 EFC36352.1 - 0.0004 20.8 0.0 0.001 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC36352.1 - 0.00052 20.3 0.0 0.0019 18.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFC36352.1 - 0.00065 19.4 0.2 0.0016 18.1 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC36352.1 - 0.0059 16.4 0.2 0.034 13.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFC36352.1 - 0.0076 16.3 0.0 0.14 12.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EFC36352.1 - 0.008 15.0 0.0 0.016 14.0 0.0 1.5 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_21 PF13304.6 EFC36352.1 - 0.018 14.9 0.1 0.37 10.5 0.0 2.3 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC36352.1 - 0.041 13.8 0.0 0.098 12.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 EFC36352.1 - 0.042 13.1 0.0 0.17 11.1 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 EFC36352.1 - 0.093 13.3 0.0 0.27 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFC36352.1 - 0.094 13.1 0.0 18 5.7 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 EFC36352.1 - 0.095 12.8 0.3 0.44 10.6 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 EFC36352.1 - 0.14 12.4 0.4 1.3 9.3 0.4 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 EFC36352.1 - 0.15 12.6 2.4 0.16 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain MAPEG PF01124.18 EFC36353.1 - 5.8e-09 35.9 0.0 7.6e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 MAPEG family Afi1 PF07792.12 EFC36354.1 - 0.039 14.4 0.3 0.054 14.0 0.3 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DNA_pol3_finger PF17657.1 EFC36354.1 - 0.17 11.2 0.8 13 5.1 0.1 2.1 1 1 1 2 2 2 0 Bacterial DNA polymerase III alpha subunit finger domain DUF4350 PF14258.6 EFC36355.1 - 0.11 12.9 0.0 0.68 10.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) SPAN-X PF07458.12 EFC36356.1 - 0.0056 17.1 3.4 0.0056 17.1 3.4 3.1 3 1 0 3 3 3 1 Sperm protein associated with nucleus, mapped to X chromosome G8 PF10162.9 EFC36357.1 - 1.2e-16 60.9 0.0 2.8e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 EFC36357.1 - 1.9 8.3 15.7 0.83 9.5 0.7 4.0 4 1 0 4 4 4 0 Right handed beta helix region Peptidase_C39_2 PF13529.6 EFC36358.1 - 1.8e-16 61.0 0.1 3.3e-16 60.1 0.0 1.5 2 0 0 2 2 2 1 Peptidase_C39 like family NHL PF01436.21 EFC36359.1 - 1.7e-22 78.2 0.2 1.5e-05 24.8 0.0 5.1 5 0 0 5 5 5 4 NHL repeat SGL PF08450.12 EFC36359.1 - 2e-07 30.9 0.0 2e-05 24.3 0.0 3.2 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 EFC36359.1 - 2.2e-07 30.4 2.3 2e-06 27.2 0.6 2.6 2 1 1 3 3 3 2 6-bladed beta-propeller Arylesterase PF01731.20 EFC36359.1 - 2.9e-06 27.4 0.1 0.047 13.9 0.0 4.3 3 1 1 4 4 4 1 Arylesterase DUF4934 PF16288.5 EFC36359.1 - 0.00079 19.3 1.0 0.0047 16.8 0.2 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4934) PQQ_2 PF13360.6 EFC36359.1 - 0.0012 18.5 0.0 0.0029 17.2 0.0 1.6 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 EFC36359.1 - 0.002 18.0 0.0 4.3 7.4 0.0 3.9 3 0 0 3 3 3 1 PQQ enzyme repeat Str_synth PF03088.16 EFC36359.1 - 0.0074 16.4 0.4 18 5.5 0.0 3.8 3 1 1 4 4 4 1 Strictosidine synthase AcrZ PF10766.9 EFC36359.1 - 0.14 11.7 0.6 18 5.0 0.0 2.3 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ mRNA_cap_enzyme PF01331.19 EFC36360.1 - 2.4e-21 76.5 5.6 1.5e-13 51.0 2.6 2.4 1 1 1 2 2 2 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 EFC36360.1 - 1.6e-09 38.4 0.1 1.2e-08 35.5 0.0 2.5 2 0 0 2 2 2 1 mRNA capping enzyme, C-terminal domain Pkinase PF00069.25 EFC36361.1 - 1.9e-53 181.5 0.1 2.8e-53 181.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36361.1 - 1.1e-23 83.9 0.3 4.8e-23 81.8 0.3 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC36361.1 - 0.0017 18.3 0.0 0.3 11.0 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC36361.1 - 0.012 15.3 2.3 0.031 13.9 1.7 1.9 1 1 1 2 2 2 0 Choline/ethanolamine kinase Dpy-30 PF05186.13 EFC36362.1 - 0.00068 19.3 0.1 0.053 13.2 0.1 2.4 2 0 0 2 2 2 2 Dpy-30 motif FeoB_Cyto PF17910.1 EFC36362.1 - 0.058 13.9 3.1 0.15 12.6 3.0 1.7 1 1 0 1 1 1 0 FeoB cytosolic helical domain DotU PF09850.9 EFC36363.1 - 0.018 14.7 0.0 0.063 13.0 0.0 1.9 2 0 0 2 2 2 0 Type VI secretion system protein DotU CID_GANP PF16766.5 EFC36363.1 - 0.046 13.9 1.4 0.096 12.9 1.4 1.5 1 0 0 1 1 1 0 Binding region of GANP to ENY2 DUF2207 PF09972.9 EFC36363.1 - 0.047 12.4 0.0 0.079 11.7 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LPAM_1 PF08139.12 EFC36364.1 - 0.13 12.8 1.8 0.18 12.3 1.8 1.2 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Trypan_PARP PF05887.11 EFC36365.1 - 1.6e-05 24.9 98.0 0.07 13.1 36.6 3.0 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) LRR_4 PF12799.7 EFC36366.1 - 9.8e-05 22.7 37.8 0.0023 18.3 1.4 8.0 4 2 2 6 6 6 4 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC36366.1 - 0.00097 19.0 0.0 0.0034 17.2 0.0 1.9 1 0 0 1 1 1 1 F-box domain Flavi_propep PF01570.17 EFC36366.1 - 0.048 13.6 0.2 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Flavivirus polyprotein propeptide LRR_8 PF13855.6 EFC36366.1 - 0.053 13.3 18.2 0.063 13.0 2.3 6.0 6 1 0 6 6 6 0 Leucine rich repeat Ntox34 PF15606.6 EFC36366.1 - 0.073 13.2 0.1 9.1 6.5 0.0 2.6 2 0 0 2 2 2 0 Bacterial toxin 34 Glyoxalase PF00903.25 EFC36367.1 - 3.3e-20 72.6 1.0 7.2e-16 58.6 0.1 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFC36367.1 - 4.4e-10 39.8 0.1 0.00016 21.9 0.0 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 EFC36367.1 - 1.4e-06 28.5 0.9 6.6e-06 26.3 0.4 2.2 2 1 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_3 PF13468.6 EFC36367.1 - 2.1e-05 24.7 0.0 0.11 12.6 0.0 2.9 2 1 0 2 2 2 2 Glyoxalase-like domain LRR_4 PF12799.7 EFC36368.1 - 7.1e-07 29.4 42.0 0.024 15.1 0.6 9.0 5 3 3 9 9 9 5 Leucine Rich repeats (2 copies) VirE1 PF12189.8 EFC36368.1 - 0.3 11.2 2.7 0.33 11.1 0.5 2.4 2 0 0 2 2 2 0 Single-strand DNA-binding protein LRR_6 PF13516.6 EFC36368.1 - 4.7 7.5 22.8 1.9 8.8 0.1 7.9 10 0 0 10 10 10 0 Leucine Rich repeat LRR_6 PF13516.6 EFC36370.1 - 2.1e-41 136.5 8.5 9e-06 25.4 0.0 8.5 8 0 0 8 8 8 8 Leucine Rich repeat LRR_8 PF13855.6 EFC36370.1 - 1.8e-20 72.4 8.3 2.2e-06 27.3 0.5 4.4 1 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC36370.1 - 8e-16 57.9 14.7 0.0033 17.8 0.0 6.1 2 2 7 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36370.1 - 9.6e-14 49.8 0.3 1.5 9.7 0.0 8.4 8 1 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC36370.1 - 0.00016 21.2 0.9 0.13 11.7 0.1 2.9 1 1 1 3 3 3 2 Leucine-rich repeat PulA_N1 PF17999.1 EFC36370.1 - 0.052 14.3 2.0 3.5 8.4 0.1 2.7 3 0 0 3 3 3 0 Pullulanase N1-terminal domain PapC_C PF13953.6 EFC36370.1 - 0.072 12.9 0.0 6.7 6.6 0.0 3.2 3 0 0 3 3 3 0 PapC C-terminal domain SBP_bac_3 PF00497.20 EFC36371.1 - 1.7e-08 34.1 0.0 2.6e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 SR-25 PF10500.9 EFC36373.1 - 0.0011 18.7 9.0 0.0022 17.6 9.0 1.5 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CTNNB1_binding PF08347.11 EFC36373.1 - 0.0088 16.3 5.8 0.0088 16.3 5.8 1.9 1 1 1 2 2 2 1 N-terminal CTNNB1 binding DUF4685 PF15737.5 EFC36373.1 - 0.044 14.2 4.8 0.12 12.8 4.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4685) ZIP4_domain PF18292.1 EFC36373.1 - 0.07 13.1 0.4 0.15 12.0 0.4 1.5 1 0 0 1 1 1 0 Zinc transporter ZIP4 domain YjcZ PF13990.6 EFC36374.1 - 0.0057 16.1 1.9 0.0065 15.9 1.6 1.3 1 1 0 1 1 1 1 YjcZ-like protein Baculo_LEF-11 PF06385.12 EFC36374.1 - 0.021 15.3 0.7 0.021 15.3 0.7 3.0 1 1 2 3 3 3 0 Baculovirus LEF-11 protein Goodbye PF17109.5 EFC36374.1 - 0.58 10.6 0.1 0.58 10.6 0.1 2.8 2 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain Herpes_BLRF2 PF05812.12 EFC36374.1 - 1.3 9.2 11.0 1.5 8.9 5.9 2.6 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein LRR_8 PF13855.6 EFC36375.1 - 0.00065 19.4 3.6 0.00065 19.4 3.6 3.2 3 1 0 3 3 3 1 Leucine rich repeat Staphostatin_B PF09023.10 EFC36375.1 - 0.32 11.0 2.4 4 7.5 1.9 3.2 2 1 0 2 2 2 0 Staphostatin B Sel1 PF08238.12 EFC36376.1 - 1.2e-48 162.5 13.8 6.6e-06 26.6 0.0 8.1 8 0 0 8 8 8 7 Sel1 repeat HTH_16 PF12645.7 EFC36376.1 - 0.071 13.2 0.0 0.41 10.7 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Peptidase_S41 PF03572.18 EFC36377.1 - 3.6e-08 33.2 0.0 1.1e-07 31.6 0.0 1.8 1 1 0 1 1 1 1 Peptidase family S41 Ras PF00071.22 EFC36378.1 - 4.5e-07 29.6 0.0 8.2e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Ras family Sec20 PF03908.13 EFC36378.1 - 0.14 12.1 1.6 0.66 9.9 0.2 2.7 3 1 1 4 4 4 0 Sec20 Ras PF00071.22 EFC36379.1 - 4.5e-26 91.4 0.2 6.8e-26 90.8 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36379.1 - 9.4e-09 35.5 0.0 1.9e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC36379.1 - 1.5e-05 24.9 0.2 0.042 13.8 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC36379.1 - 0.00065 19.3 0.1 0.0011 18.6 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain CbiA PF01656.23 EFC36379.1 - 0.0027 17.7 0.1 1.6 8.8 0.0 2.3 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 EFC36379.1 - 0.0035 17.2 0.4 0.012 15.5 0.1 1.9 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 EFC36379.1 - 0.0049 16.3 2.0 0.045 13.1 0.4 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region ParA PF10609.9 EFC36379.1 - 0.02 14.4 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase NTPase_1 PF03266.15 EFC36379.1 - 0.043 13.7 0.0 0.099 12.5 0.0 1.8 1 1 0 1 1 1 0 NTPase FeoB_N PF02421.18 EFC36379.1 - 0.18 11.4 1.9 0.33 10.4 0.2 2.1 2 1 0 2 2 2 0 Ferrous iron transport protein B UCH PF00443.29 EFC36380.1 - 9.1e-05 22.1 5.7 0.00013 21.6 5.7 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase tRNA-synt_1c PF00749.21 EFC36381.1 - 0.055 12.3 0.6 0.058 12.3 0.6 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain LRR_6 PF13516.6 EFC36382.1 - 1.8e-20 71.1 42.6 0.0015 18.4 0.1 13.0 14 0 0 14 14 14 8 Leucine Rich repeat LRR_4 PF12799.7 EFC36382.1 - 2.5e-15 56.3 54.3 0.0014 19.0 4.2 10.0 4 4 6 11 11 11 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36382.1 - 5.2e-15 55.0 42.4 2.3e-05 24.0 8.3 6.9 4 2 3 7 7 7 6 Leucine rich repeat LRR_1 PF00560.33 EFC36382.1 - 5.5e-05 23.2 30.4 2.8 8.8 0.2 10.5 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC36382.1 - 0.00025 20.6 24.4 0.062 12.8 2.2 5.0 1 1 2 5 5 5 4 Leucine-rich repeat HTH_26 PF13443.6 EFC36382.1 - 0.039 14.4 0.1 0.29 11.6 0.0 2.6 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain DUF4476 PF14771.6 EFC36383.1 - 8.8e-32 109.3 1.2 6.3e-23 80.9 0.1 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) Bromo_TP PF07524.13 EFC36383.1 - 0.0083 16.1 0.2 0.91 9.6 0.0 2.8 2 1 1 3 3 3 1 Bromodomain associated Clp_N PF02861.20 EFC36383.1 - 0.044 13.9 0.4 0.96 9.6 0.1 3.0 3 1 1 4 4 4 0 Clp amino terminal domain, pathogenicity island component Hum_adeno_E3A PF05393.11 EFC36384.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein LRR_4 PF12799.7 EFC36385.1 - 1.1e-08 35.3 53.0 0.0074 16.7 8.7 7.5 2 2 5 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC36385.1 - 9.4e-05 22.2 36.9 0.0058 16.6 0.5 8.4 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 EFC36385.1 - 0.0015 18.8 38.7 9.2 7.3 0.4 9.2 6 3 2 8 8 8 5 Leucine Rich Repeat LRR_8 PF13855.6 EFC36385.1 - 0.44 10.4 41.2 3.4 7.5 0.5 6.7 4 3 2 6 6 6 0 Leucine rich repeat DNMT1-RFD PF12047.8 EFC36386.1 - 2.2e-08 34.3 0.6 2.2e-08 34.3 0.6 2.8 3 0 0 3 3 3 1 Cytosine specific DNA methyltransferase replication foci domain RHH_1 PF01402.21 EFC36386.1 - 5.4 7.1 6.8 3.5 7.7 0.5 3.1 2 1 0 2 2 2 0 Ribbon-helix-helix protein, copG family SH3_1 PF00018.28 EFC36387.1 - 2.3e-14 52.7 0.4 6.4e-14 51.3 0.4 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFC36387.1 - 1.2e-13 50.7 0.8 1.2e-13 50.7 0.8 2.0 2 0 0 2 2 2 1 Variant SH3 domain Cofilin_ADF PF00241.20 EFC36387.1 - 2.3e-12 46.8 0.1 2.3e-12 46.8 0.1 2.1 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 EFC36387.1 - 4.3e-12 45.5 0.1 1.3e-11 44.0 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_4 PF06347.13 EFC36387.1 - 0.081 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain ubiquitin PF00240.23 EFC36388.1 - 4.2e-31 106.5 0.4 4.6e-31 106.4 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC36388.1 - 2e-15 56.4 0.3 2.2e-15 56.2 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC36388.1 - 0.00036 20.9 0.2 0.0016 18.9 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC36388.1 - 0.0048 16.8 0.0 0.0051 16.7 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC36388.1 - 0.014 15.5 0.0 0.03 14.4 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFC36388.1 - 0.021 14.8 0.5 1.4 9.0 0.2 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC36388.1 - 0.036 14.4 0.1 0.043 14.2 0.1 1.1 1 0 0 1 1 1 0 Ubiquitin-like domain TUG-UBL1 PF11470.8 EFC36388.1 - 0.087 13.1 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 TUG ubiquitin-like domain C2 PF00168.30 EFC36389.1 - 2.8e-19 69.3 0.1 2.1e-11 44.0 0.0 2.2 2 0 0 2 2 2 2 C2 domain NT-C2 PF10358.9 EFC36389.1 - 0.086 12.6 1.0 0.15 11.7 0.3 1.8 2 0 0 2 2 2 0 N-terminal C2 in EEIG1 and EHBP1 proteins GNT-I PF03071.15 EFC36390.1 - 5.7e-07 28.7 1.3 2.9e-06 26.3 1.3 1.8 1 1 0 1 1 1 1 GNT-I family Collagen PF01391.18 EFC36391.1 - 0.00063 19.5 6.9 0.00063 19.5 6.9 5.4 4 1 0 4 4 4 2 Collagen triple helix repeat (20 copies) DUF4795 PF16043.5 EFC36391.1 - 0.17 11.4 0.7 0.28 10.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Peptidase_C1 PF00112.23 EFC36392.1 - 3.5e-52 177.6 7.6 4.2e-52 177.4 7.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC36392.1 - 0.12 11.1 0.3 0.2 10.4 0.3 1.2 1 0 0 1 1 1 0 Peptidase C1-like family CarbpepA_inh PF02977.15 EFC36392.1 - 0.74 9.7 9.4 0.24 11.2 4.6 2.3 2 0 0 2 2 2 0 Carboxypeptidase A inhibitor BTB PF00651.31 EFC36393.1 - 4.5e-06 26.9 0.1 0.0001 22.5 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain SARAF PF06682.12 EFC36395.1 - 0.0012 18.6 0.1 0.0013 18.5 0.1 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis C2 PF00168.30 EFC36396.1 - 4.5e-10 39.7 0.3 7.9e-10 39.0 0.3 1.4 1 0 0 1 1 1 1 C2 domain LRR_4 PF12799.7 EFC36397.1 - 0.0073 16.7 28.7 1.1 9.8 1.4 6.7 3 3 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36397.1 - 0.12 13.0 12.4 31 5.7 0.0 6.7 7 0 0 7 7 7 0 Leucine Rich Repeat F-box PF00646.33 EFC36398.1 - 0.00011 22.0 0.4 0.00011 22.0 0.4 2.3 2 1 1 3 3 3 1 F-box domain F-box-like PF12937.7 EFC36398.1 - 0.015 15.2 1.8 0.019 14.8 0.5 1.8 2 0 0 2 2 2 0 F-box-like F-box_4 PF15966.5 EFC36398.1 - 0.015 15.1 0.3 0.056 13.3 0.0 2.1 2 0 0 2 2 2 0 F-box ACP53EA PF06313.11 EFC36398.1 - 0.02 15.0 0.2 0.1 12.8 0.0 2.1 2 0 0 2 2 2 0 Drosophila ACP53EA protein Vps8 PF12816.7 EFC36398.1 - 0.03 13.8 0.2 0.046 13.2 0.2 1.2 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 EGF_2 PF07974.13 EFC36400.1 - 2.1e-43 146.3 163.8 6.7e-05 23.2 6.8 10.5 10 0 0 10 10 10 10 EGF-like domain EGF PF00008.27 EFC36400.1 - 5.9e-13 48.9 118.1 0.064 13.6 3.8 11.7 10 1 1 11 11 11 9 EGF-like domain NHL PF01436.21 EFC36400.1 - 4.5e-12 45.3 7.2 4.4e-06 26.5 0.0 7.8 9 0 0 9 9 9 2 NHL repeat SGL PF08450.12 EFC36400.1 - 0.002 17.8 2.8 19 4.8 0.0 4.4 2 1 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region TMEM154 PF15102.6 EFC36400.1 - 0.013 15.4 2.1 0.013 15.4 2.1 1.9 2 0 0 2 2 2 0 TMEM154 protein family ECF_trnsprt PF12822.7 EFC36400.1 - 0.029 14.5 0.2 0.062 13.4 0.2 1.4 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Gram_pos_anchor PF00746.21 EFC36400.1 - 0.053 13.5 1.8 0.12 12.3 0.2 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Methylase_S PF01420.19 EFC36400.1 - 0.084 13.1 2.1 0.64 10.2 0.1 2.8 2 1 0 2 2 2 0 Type I restriction modification DNA specificity domain PepSY_TM PF03929.16 EFC36401.1 - 0.059 13.0 1.1 0.12 12.0 1.0 1.6 1 1 0 1 1 1 0 PepSY-associated TM region GWT1 PF06423.12 EFC36401.1 - 0.12 12.5 7.5 0.12 12.6 4.6 2.2 1 1 1 2 2 2 0 GWT1 COX7a PF02238.15 EFC36401.1 - 1.3 9.4 4.5 23 5.5 2.1 2.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VII Peptidase_S8 PF00082.22 EFC36402.1 - 1.6e-38 132.7 1.4 9.5e-38 130.1 1.4 2.1 1 1 0 1 1 1 1 Subtilase family fn3 PF00041.21 EFC36402.1 - 1.7e-05 25.1 0.2 6.3e-05 23.2 0.2 2.0 1 1 0 1 1 1 1 Fibronectin type III domain Phage_holin_3_6 PF07332.11 EFC36402.1 - 0.12 12.4 0.1 11 6.1 0.1 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III adh_short PF00106.25 EFC36403.1 - 1.7e-19 70.0 0.0 2e-18 66.6 0.0 1.9 1 1 1 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36403.1 - 9.9e-11 41.6 0.0 1.3e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC36403.1 - 1.4e-07 31.6 0.0 1.8e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 KR domain TFIID_NTD2 PF04494.15 EFC36404.1 - 0.011 15.9 0.4 0.061 13.5 0.2 2.2 2 0 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain Ras PF00071.22 EFC36405.1 - 1.7e-27 96.0 0.3 2.7e-27 95.4 0.3 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36405.1 - 2.2e-10 40.8 0.0 4.8e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC36405.1 - 5.5e-05 23.1 0.2 0.16 11.9 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC36405.1 - 0.00085 18.9 0.1 0.0014 18.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC36405.1 - 0.0013 18.2 2.0 0.016 14.6 0.6 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EFC36405.1 - 0.0019 18.0 0.3 0.0019 18.0 0.3 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein ParA PF10609.9 EFC36405.1 - 0.0089 15.5 0.1 0.015 14.8 0.1 1.4 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase FeoB_N PF02421.18 EFC36405.1 - 0.015 14.8 0.9 0.043 13.4 0.1 2.0 2 1 0 2 2 2 0 Ferrous iron transport protein B CbiA PF01656.23 EFC36405.1 - 0.12 12.5 2.8 2.5 8.1 2.8 2.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.27 EFC36406.1 - 9.9e-23 80.7 0.0 1.5e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC36406.1 - 2.5e-17 63.2 0.0 6.9e-17 61.8 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC36406.1 - 0.00015 22.1 0.0 0.00043 20.6 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC36406.1 - 0.0045 17.1 0.0 0.067 13.3 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC36406.1 - 0.02 14.2 0.1 0.036 13.4 0.1 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Septin PF00735.18 EFC36406.1 - 0.1 11.8 0.0 0.54 9.5 0.0 1.9 1 1 0 1 1 1 0 Septin RE_R_Pab1 PF09522.10 EFC36406.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.7 1 0 0 1 1 1 0 R.Pab1 restriction endonuclease EGF_2 PF07974.13 EFC36407.1 - 1.1e-43 147.2 230.7 8.3e-06 26.1 7.2 13.7 12 1 1 13 13 13 13 EGF-like domain EGF PF00008.27 EFC36407.1 - 1.9e-07 31.2 189.1 0.14 12.5 8.4 13.9 13 0 0 13 13 13 11 EGF-like domain B_lectin PF01453.24 EFC36407.1 - 0.016 15.8 1.0 2.3 8.8 0.0 3.2 2 1 0 3 3 3 0 D-mannose binding lectin Plavaka PF18759.1 EFC36411.1 - 0.043 13.1 2.5 0.5 9.5 2.5 2.1 1 1 0 1 1 1 0 Plavaka transposase F5_F8_type_C PF00754.25 EFC36412.1 - 0.00076 19.6 0.1 0.00076 19.6 0.1 2.8 4 0 0 4 4 4 1 F5/8 type C domain Gag_p17 PF00540.18 EFC36413.1 - 0.017 15.1 0.1 0.049 13.6 0.0 1.7 1 1 0 1 1 1 0 gag gene protein p17 (matrix protein) FERM_C PF09380.10 EFC36413.1 - 0.04 14.3 0.1 0.091 13.2 0.1 1.6 1 0 0 1 1 1 0 FERM C-terminal PH-like domain Orthopox_A36R PF05950.11 EFC36413.1 - 0.056 13.6 2.3 0.15 12.2 2.3 1.7 1 0 0 1 1 1 0 Orthopoxvirus A36R protein AMP-binding PF00501.28 EFC36415.1 - 1.1e-59 202.1 0.0 2.1e-59 201.3 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFC36415.1 - 7.5e-54 182.6 0.0 1.3e-53 181.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFC36415.1 - 0.0047 16.4 0.0 0.013 14.9 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Synaptonemal_3 PF15191.6 EFC36415.1 - 0.071 12.9 2.2 0.21 11.4 0.2 2.7 2 0 0 2 2 2 0 Synaptonemal complex central element protein 3 PP-binding PF00550.25 EFC36415.1 - 0.13 12.6 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Phosphopantetheine attachment site N-SET PF11764.8 EFC36415.1 - 0.34 11.0 3.5 23 5.1 0.0 3.4 3 0 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component N CRCB PF02537.15 EFC36416.1 - 3.7e-30 104.1 18.9 5.1e-16 58.8 10.0 3.0 3 0 0 3 3 3 2 CrcB-like protein, Camphor Resistance (CrcB) Ribonuc_L-PSP PF01042.21 EFC36419.1 - 3e-24 85.4 0.4 2.4e-17 63.0 0.1 2.2 1 1 1 2 2 2 2 Endoribonuclease L-PSP PhoPQ_related PF10142.9 EFC36420.1 - 3.9e-97 325.2 0.4 4.6e-97 324.9 0.4 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DUF3934 PF13070.6 EFC36420.1 - 0.1 13.1 0.1 0.23 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3934) Actin PF00022.19 EFC36421.1 - 1.3e-65 221.6 0.0 1.4e-63 214.9 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC36421.1 - 0.015 14.2 0.0 0.068 12.0 0.0 1.9 1 1 0 1 1 1 0 MreB/Mbl protein RGS PF00615.19 EFC36422.1 - 4.5e-11 43.1 6.6 4.5e-11 43.1 6.6 3.6 3 1 1 4 4 4 1 Regulator of G protein signaling domain AhpC-TSA PF00578.21 EFC36422.1 - 1.2e-05 25.2 0.1 3.4e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EFC36422.1 - 0.0027 17.4 0.0 0.012 15.3 0.0 2.0 1 1 1 2 2 2 1 Redoxin SR-25 PF10500.9 EFC36422.1 - 0.57 9.8 7.7 0.9 9.1 7.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Acetyltransf_2 PF00797.17 EFC36422.1 - 0.85 9.4 6.4 0.19 11.5 1.7 2.3 2 0 0 2 2 2 0 N-acetyltransferase F-box PF00646.33 EFC36423.1 - 0.002 17.9 0.2 0.0044 16.9 0.2 1.6 1 0 0 1 1 1 1 F-box domain Stevor PF17410.2 EFC36423.1 - 0.011 15.3 2.1 0.019 14.5 2.1 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame F-box-like PF12937.7 EFC36423.1 - 0.12 12.3 0.2 0.23 11.4 0.2 1.4 1 0 0 1 1 1 0 F-box-like Palm_thioest PF02089.15 EFC36424.1 - 5.3e-42 144.3 0.1 9.9e-39 133.6 0.1 2.0 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 EFC36424.1 - 6.2e-05 22.4 0.0 9.4e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC36424.1 - 6.6e-05 22.7 0.0 0.00014 21.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 EFC36424.1 - 0.014 14.7 0.0 0.076 12.3 0.0 2.0 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) DUF900 PF05990.12 EFC36424.1 - 0.18 11.3 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) MFS_1 PF07690.16 EFC36425.1 - 6.1e-19 68.2 27.7 1.5e-18 66.9 27.8 1.6 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 EFC36425.1 - 0.45 9.3 17.9 0.0063 15.4 3.3 2.5 2 1 0 2 2 2 0 MFS_1 like family GPI-anchored PF10342.9 EFC36426.1 - 0.046 14.5 0.8 0.18 12.6 0.3 2.3 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Peptidase_S9 PF00326.21 EFC36427.1 - 1.4e-57 194.6 0.1 2.1e-57 194.0 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC36427.1 - 1.1e-05 25.2 2.6 0.035 13.8 0.0 2.8 2 1 1 3 3 3 2 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EFC36427.1 - 0.00041 20.0 0.1 0.26 10.8 0.0 2.5 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PD40 PF07676.12 EFC36427.1 - 0.002 18.0 3.9 0.0022 17.9 0.4 2.8 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DLH PF01738.18 EFC36427.1 - 0.064 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF4834 PF16118.5 EFC36428.1 - 0.31 12.0 0.0 0.31 12.0 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) NHL PF01436.21 EFC36429.1 - 9.8e-24 82.2 3.9 7.5e-06 25.7 0.0 8.1 9 0 0 9 9 9 5 NHL repeat SGL PF08450.12 EFC36429.1 - 0.0016 18.0 0.3 0.025 14.2 0.1 3.1 3 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region FNIP_C PF14638.6 EFC36429.1 - 0.049 13.3 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus TatD_DNase PF01026.21 EFC36430.1 - 8.1e-34 117.1 0.0 1.2e-33 116.6 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase Gemini_AL1_M PF08283.11 EFC36430.1 - 0.00099 19.2 0.0 0.017 15.2 0.0 2.4 2 0 0 2 2 2 1 Geminivirus rep protein central domain Exo_endo_phos PF03372.23 EFC36431.1 - 0.034 13.7 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Methyltrans_RNA PF04452.14 EFC36431.1 - 0.069 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 RNA methyltransferase LRR_6 PF13516.6 EFC36432.1 - 1.2e-25 87.3 33.2 0.00028 20.7 0.2 12.6 13 0 0 13 13 13 8 Leucine Rich repeat LRR_8 PF13855.6 EFC36432.1 - 4.5e-23 80.8 29.8 1.4e-07 31.2 2.2 7.3 2 1 7 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EFC36432.1 - 1e-17 63.9 35.4 0.00073 19.9 2.2 8.7 2 1 8 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36432.1 - 4e-09 35.8 21.5 4.8 8.1 0.2 10.9 9 2 0 9 9 9 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC36432.1 - 5.4e-06 26.0 7.5 0.00088 18.8 1.3 3.3 1 1 3 4 4 4 3 Leucine-rich repeat EFhand_Ca_insen PF08726.10 EFC36432.1 - 0.018 15.1 0.2 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 Ca2+ insensitive EF hand FTH PF01827.27 EFC36432.1 - 0.34 10.7 9.7 2.1 8.1 2.3 2.8 2 1 0 2 2 2 0 FTH domain Ras PF00071.22 EFC36434.1 - 7.1e-08 32.2 0.1 9.2e-08 31.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC36434.1 - 0.034 13.6 0.0 0.036 13.5 0.0 1.0 1 0 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC36434.1 - 0.078 12.5 0.1 0.094 12.2 0.1 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Roc PF08477.13 EFC36434.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC36435.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 F-box-like AAA_16 PF13191.6 EFC36436.1 - 6.2e-05 23.4 0.0 0.00014 22.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFC36436.1 - 0.00013 21.9 0.1 0.03 14.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase DUF815 PF05673.13 EFC36436.1 - 0.00033 19.9 0.0 0.00094 18.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 EFC36436.1 - 0.0028 17.3 0.0 0.006 16.3 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFC36436.1 - 0.003 17.8 0.0 0.0082 16.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain IIGP PF05049.13 EFC36436.1 - 0.0035 16.4 0.0 0.0056 15.8 0.0 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 EFC36436.1 - 0.0052 17.3 0.0 0.016 15.7 0.0 1.9 1 0 0 1 1 1 1 ABC transporter Roc PF08477.13 EFC36436.1 - 0.0066 16.7 0.1 0.029 14.6 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC36436.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Ras family MMR_HSR1 PF01926.23 EFC36436.1 - 0.013 15.6 0.0 0.03 14.4 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 EFC36436.1 - 0.016 14.9 0.8 0.13 11.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFC36436.1 - 0.018 14.5 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 EFC36436.1 - 0.062 13.3 0.2 0.39 10.7 0.0 2.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFC36436.1 - 0.072 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Ribonuclease_3 PF00636.26 EFC36437.1 - 0.13 12.9 1.0 0.2 12.3 1.0 1.6 1 1 0 1 1 1 0 Ribonuclease III domain TMEM144 PF07857.12 EFC36438.1 - 8.2e-16 57.9 24.2 7.3e-14 51.5 24.2 2.1 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EFC36438.1 - 1.1e-07 31.5 24.6 4.6e-07 29.5 3.6 2.2 2 0 0 2 2 2 2 Sugar transport protein SPC25 PF06703.11 EFC36438.1 - 9 6.1 7.7 1.4 8.6 3.3 1.9 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) FAST_1 PF06743.15 EFC36439.1 - 0.027 14.4 1.4 0.26 11.3 0.1 2.8 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 F-box-like PF12937.7 EFC36440.1 - 5.8e-05 22.9 1.2 0.00013 21.8 1.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC36440.1 - 0.019 14.8 0.6 0.043 13.7 0.6 1.7 1 0 0 1 1 1 0 F-box domain PRANC PF09372.10 EFC36440.1 - 0.029 14.7 1.1 0.029 14.7 1.1 3.1 3 0 0 3 3 3 0 PRANC domain 3HCDH_N PF02737.18 EFC36442.1 - 2.1e-49 167.8 0.0 4.3e-49 166.8 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 EFC36442.1 - 5e-25 88.2 0.0 8.6e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase 3HCDH PF00725.22 EFC36442.1 - 1e-22 80.6 0.0 2.4e-15 56.9 0.0 2.6 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain ECH_2 PF16113.5 EFC36442.1 - 2.4e-17 63.5 0.0 5.2e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Pyr_redox_2 PF07992.14 EFC36442.1 - 0.17 11.1 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F420_oxidored PF03807.17 EFC36443.1 - 1.6e-18 67.0 0.1 3.2e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFC36443.1 - 2.9e-09 37.3 0.0 8.6e-09 35.8 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFC36443.1 - 2.5e-08 33.5 0.0 4.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 EFC36443.1 - 2.9e-05 24.1 0.2 6.8e-05 22.9 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 EFC36443.1 - 9.5e-05 22.3 0.1 0.00025 21.0 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EFC36443.1 - 0.0001 22.3 0.4 0.00092 19.2 0.4 2.4 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.9 EFC36443.1 - 0.0002 21.2 0.0 0.00035 20.4 0.0 1.4 1 0 0 1 1 1 1 Rossmann-like domain ApbA PF02558.16 EFC36443.1 - 0.00098 18.8 1.7 0.0034 17.0 1.5 2.0 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 EFC36443.1 - 0.0026 17.4 0.0 0.0047 16.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain IlvN PF07991.12 EFC36443.1 - 0.0028 17.2 0.0 0.0044 16.6 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 EFC36443.1 - 0.0039 17.4 0.1 0.0089 16.3 0.1 1.6 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_8 PF13450.6 EFC36443.1 - 0.0053 16.9 0.4 0.013 15.7 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Sacchrp_dh_NADP PF03435.18 EFC36443.1 - 0.0054 17.0 0.4 0.02 15.2 0.1 2.1 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFC36443.1 - 0.0084 16.0 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 KR domain XdhC_C PF13478.6 EFC36443.1 - 0.015 15.8 0.0 0.033 14.7 0.0 1.8 1 1 0 1 1 1 0 XdhC Rossmann domain Epimerase PF01370.21 EFC36443.1 - 0.017 14.6 0.1 0.045 13.2 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family GFO_IDH_MocA PF01408.22 EFC36443.1 - 0.023 15.5 0.0 0.046 14.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold adh_short PF00106.25 EFC36443.1 - 0.036 13.5 0.1 0.079 12.4 0.1 1.6 1 0 0 1 1 1 0 short chain dehydrogenase FAD_binding_3 PF01494.19 EFC36443.1 - 0.041 13.1 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_10 PF13460.6 EFC36443.1 - 0.082 12.8 0.6 0.14 12.1 0.1 1.6 2 0 0 2 2 1 0 NAD(P)H-binding Ldh_1_N PF00056.23 EFC36443.1 - 0.1 12.7 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 EFC36443.1 - 0.15 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase TLD PF07534.16 EFC36444.1 - 4e-17 62.7 3.0 7e-17 61.9 3.0 1.4 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFC36444.1 - 0.0019 18.5 0.0 0.0053 17.1 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain EF1_GNE PF00736.19 EFC36444.1 - 0.094 12.9 0.3 0.24 11.6 0.2 1.8 2 0 0 2 2 2 0 EF-1 guanine nucleotide exchange domain NHL PF01436.21 EFC36445.1 - 2.2e-22 77.9 3.1 5.5e-05 23.0 0.1 5.7 5 0 0 5 5 5 4 NHL repeat DUF5128 PF17170.4 EFC36445.1 - 6.8e-07 28.7 7.3 0.0037 16.5 0.0 3.6 3 1 1 4 4 4 2 6-bladed beta-propeller SGL PF08450.12 EFC36445.1 - 8.5e-06 25.5 0.0 0.029 14.0 0.0 3.6 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC36445.1 - 0.0012 19.0 0.0 2.3 8.5 0.0 3.2 3 0 0 3 3 3 2 Arylesterase SBBP PF06739.11 EFC36445.1 - 0.0052 16.8 1.4 5.1 7.2 0.0 3.7 5 0 0 5 5 5 2 Beta-propeller repeat Ldl_recept_b PF00058.17 EFC36445.1 - 0.15 12.5 0.0 24 5.5 0.0 3.1 3 0 0 3 3 3 0 Low-density lipoprotein receptor repeat class B Pkinase PF00069.25 EFC36446.1 - 5.9e-09 35.7 0.0 3.2e-08 33.3 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36446.1 - 5e-05 22.7 0.0 8.2e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.17 EFC36447.1 - 4.7e-22 78.5 0.1 7.7e-22 77.8 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC36447.1 - 1.9e-16 60.2 0.1 3.3e-16 59.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Nop PF01798.18 EFC36447.1 - 5.4e-09 35.9 0.1 5.4e-09 35.9 0.1 1.5 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin DUF3660 PF12398.8 EFC36447.1 - 0.016 15.2 0.3 0.45 10.6 0.1 2.6 2 0 0 2 2 2 0 Receptor serine/threonine kinase PSD2 PF07624.11 EFC36447.1 - 0.13 12.1 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1585) RNB PF00773.19 EFC36448.1 - 2.4e-74 250.6 0.4 2.4e-74 250.6 0.4 2.6 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 EFC36448.1 - 1.8e-11 43.9 0.0 5.2e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PAP_assoc PF03828.19 EFC36448.1 - 1.4e-09 38.1 0.1 6.5e-09 35.9 0.1 2.3 1 0 0 1 1 1 1 Cid1 family poly A polymerase Rrp44_CSD1 PF17216.3 EFC36448.1 - 1.8e-07 30.9 0.1 2.1e-06 27.5 0.1 2.5 2 0 0 2 2 2 1 Rrp44-like cold shock domain NTP_transf_2 PF01909.23 EFC36448.1 - 2.1e-05 24.7 1.7 0.00025 21.3 0.0 2.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFC36448.1 - 0.00026 21.0 3.4 0.0014 18.6 0.1 3.6 2 1 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase Dis3l2_C_term PF17877.1 EFC36448.1 - 0.0043 17.3 0.0 0.039 14.3 0.0 2.8 1 1 0 1 1 1 1 DIS3-like exonuclease 2 C terminal OB_RNB PF08206.11 EFC36448.1 - 0.016 14.9 0.1 0.045 13.4 0.1 1.8 1 0 0 1 1 1 0 Ribonuclease B OB domain Glyco_hydro_14 PF01373.17 EFC36449.1 - 4e-101 338.9 2.1 4.9e-101 338.6 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 Glyco_hydro_35 PF01301.19 EFC36449.1 - 0.00012 21.8 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 MF_alpha_N PF05436.11 EFC36450.1 - 0.038 13.9 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 Mating factor alpha precursor N-terminus RGS PF00615.19 EFC36451.1 - 4.5e-08 33.4 5.7 1e-07 32.2 5.7 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF2207 PF09972.9 EFC36451.1 - 0.0079 15.0 0.2 0.0079 15.0 0.2 2.5 2 1 1 3 3 3 1 Predicted membrane protein (DUF2207) DUF4064 PF13273.6 EFC36451.1 - 0.013 15.8 3.2 1.3 9.3 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF443 PF04276.12 EFC36451.1 - 1.4 8.7 7.8 0.55 10.0 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF443) Spore_GerAC PF05504.11 EFC36451.1 - 8.8 6.5 9.1 0.55 10.4 0.6 3.0 4 0 0 4 4 4 0 Spore germination B3/ GerAC like, C-terminal RNase_H PF00075.24 EFC36452.1 - 4.9e-11 43.0 0.1 2.5e-10 40.7 0.1 2.4 1 0 0 1 1 1 1 RNase H UPF0223 PF05256.12 EFC36452.1 - 2.2e-05 24.7 5.8 0.00013 22.3 0.2 3.7 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0223) Rootletin PF15035.6 EFC36452.1 - 0.99 9.4 9.8 0.25 11.3 5.7 2.2 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion HTH_19 PF12844.7 EFC36452.1 - 2.1 8.4 5.3 0.33 11.0 0.2 2.4 3 0 0 3 3 3 0 Helix-turn-helix domain Aminotran_5 PF00266.19 EFC36454.1 - 9.5e-33 113.7 0.0 4.5e-27 95.0 0.0 2.2 1 1 1 2 2 2 2 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFC36454.1 - 3.7e-07 29.6 0.5 5.7e-05 22.5 0.5 2.3 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFC36454.1 - 0.044 12.3 0.0 0.073 11.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme mTERF PF02536.14 EFC36455.1 - 0.00089 18.3 0.0 0.0014 17.6 0.0 1.2 1 0 0 1 1 1 1 mTERF Zn_clus PF00172.18 EFC36455.1 - 0.0056 16.8 1.7 0.0056 16.8 1.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RGS PF00615.19 EFC36456.1 - 1.4e-07 31.8 4.9 4.1e-07 30.3 4.9 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Hemopexin PF00045.19 EFC36456.1 - 0.081 12.9 0.6 0.2 11.6 0.1 1.9 2 0 0 2 2 2 0 Hemopexin Mem_trans PF03547.18 EFC36457.1 - 4.2e-18 64.9 6.8 1.1e-17 63.6 6.8 1.6 1 1 0 1 1 1 1 Membrane transport protein DUF3382 PF11862.8 EFC36457.1 - 0.074 13.3 0.2 0.25 11.7 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3382) GP41 PF00517.17 EFC36457.1 - 4.4 7.2 6.6 0.52 10.2 0.4 2.2 2 1 0 2 2 2 0 Retroviral envelope protein HemolysinCabind PF00353.19 EFC36458.1 - 0.87 9.7 3.8 1.5 8.9 1.1 2.6 3 0 0 3 3 3 0 RTX calcium-binding nonapeptide repeat (4 copies) REJ PF02010.15 EFC36459.1 - 6.1e-43 147.2 14.1 5e-40 137.6 6.1 2.7 1 1 1 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC36459.1 - 5.4e-19 68.3 240.2 8.4e-05 22.9 10.5 16.4 15 1 0 15 15 15 9 EGF-like domain TMEM154 PF15102.6 EFC36459.1 - 6.4e-06 26.1 0.5 3.9e-05 23.6 0.5 2.4 1 0 0 1 1 1 1 TMEM154 protein family DAG1 PF05454.11 EFC36459.1 - 0.0023 17.4 0.5 0.0046 16.4 0.5 1.4 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Big_3_3 PF13750.6 EFC36459.1 - 0.0038 16.9 3.2 0.0047 16.6 0.1 2.8 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 3) EGF PF00008.27 EFC36459.1 - 0.012 15.9 5.1 0.012 15.9 5.1 13.8 13 0 0 13 13 13 0 EGF-like domain DUF4713 PF15831.5 EFC36459.1 - 0.019 15.4 4.9 0.048 14.1 4.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) TMIE PF16038.5 EFC36459.1 - 0.13 12.2 0.8 0.3 10.9 0.8 1.6 1 0 0 1 1 1 0 TMIE protein EphA2_TM PF14575.6 EFC36459.1 - 0.14 13.1 1.0 0.77 10.7 0.2 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 EFC36459.1 - 0.16 12.3 2.4 1 9.7 0.4 2.4 2 0 0 2 2 2 0 Orf78 (ac78) DUF4064 PF13273.6 EFC36459.1 - 1 9.7 4.6 0.43 10.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) PDR_CDR PF06422.12 EFC36460.1 - 0.042 13.7 0.6 0.14 12.0 0.6 1.9 1 0 0 1 1 1 0 CDR ABC transporter Peptidase_S66C PF17676.1 EFC36462.1 - 0.014 15.9 0.3 0.025 15.1 0.3 1.4 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain Ins_P5_2-kin PF06090.12 EFC36462.1 - 0.089 12.2 3.6 0.097 12.1 1.5 1.7 1 1 1 2 2 2 0 Inositol-pentakisphosphate 2-kinase CRS1_YhbY PF01985.21 EFC36462.1 - 0.48 10.6 2.8 3.7 7.8 2.8 2.3 1 1 0 1 1 1 0 CRS1 / YhbY (CRM) domain GSH_synth_ATP PF03917.17 EFC36463.1 - 0.0063 15.3 0.3 0.012 14.4 0.3 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain DUF2533 PF10752.9 EFC36463.1 - 0.12 12.8 0.4 0.68 10.4 0.4 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2533) ubiquitin PF00240.23 EFC36464.1 - 2.4e-17 62.4 0.2 7.6e-17 60.8 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin family PHM7_cyt PF14703.6 EFC36464.1 - 3.5e-11 43.7 5.9 5.8e-11 42.9 0.2 3.3 3 0 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Rad60-SLD PF11976.8 EFC36464.1 - 1.7e-05 24.5 0.2 4.8e-05 23.1 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RRM_1 PF00076.22 EFC36464.1 - 0.022 14.6 0.2 0.47 10.3 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF573 PF04504.14 EFC36464.1 - 0.042 14.5 2.0 3.9 8.2 0.1 3.9 3 0 0 3 3 3 0 Protein of unknown function, DUF573 DUF2407 PF10302.9 EFC36464.1 - 0.39 11.3 0.0 0.39 11.3 0.0 3.6 4 0 0 4 4 4 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC36464.1 - 0.46 10.6 0.0 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like AAA_19 PF13245.6 EFC36467.1 - 6.4e-05 23.3 0.5 4.5 7.6 0.0 3.5 3 0 0 3 3 3 3 AAA domain HTH_Mga PF08280.11 EFC36467.1 - 0.23 11.5 2.7 15 5.7 0.4 3.2 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain C2 PF00168.30 EFC36468.1 - 2.3e-25 88.8 0.0 3.5e-25 88.3 0.0 1.3 1 0 0 1 1 1 1 C2 domain Pro-rich PF15240.6 EFC36468.1 - 0.00091 19.5 32.7 0.0014 19.0 32.7 1.3 1 0 0 1 1 1 1 Proline-rich DDE_Tnp_IS66 PF03050.14 EFC36469.1 - 0.19 11.2 0.4 0.3 10.5 0.4 1.3 1 0 0 1 1 1 0 Transposase IS66 family Ino80_Iec3 PF14612.6 EFC36469.1 - 9.1 6.9 14.0 0.9 10.1 6.2 2.6 2 1 1 3 3 3 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling Pkinase_Tyr PF07714.17 EFC36471.1 - 0.00028 20.3 0.2 0.0024 17.2 0.2 1.9 2 0 0 2 2 2 2 Protein tyrosine kinase Ank_2 PF12796.7 EFC36472.1 - 0.00011 22.7 0.0 0.00025 21.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC36472.1 - 0.0015 18.8 0.1 0.079 13.5 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFC36472.1 - 0.025 15.2 0.0 0.066 13.8 0.0 1.8 1 1 0 1 1 1 0 Ankyrin repeats (many copies) Guanylate_cyc PF00211.20 EFC36473.1 - 4.5e-44 150.3 2.0 3.7e-43 147.3 0.9 2.2 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC36473.1 - 3.7e-11 43.2 0.2 5.3e-07 29.8 0.0 3.3 3 0 0 3 3 3 2 PAS domain PAS PF00989.25 EFC36473.1 - 4.9e-11 42.6 0.0 2.4e-07 30.8 0.0 2.8 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 EFC36473.1 - 1.5e-07 31.7 0.0 0.00086 19.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 EFC36473.1 - 0.00015 21.7 0.0 0.99 9.5 0.0 3.4 3 0 0 3 3 3 2 PAS domain PAS_10 PF13596.6 EFC36473.1 - 0.021 15.4 0.0 0.13 12.9 0.0 2.3 2 0 0 2 2 2 0 PAS domain PAS_3 PF08447.12 EFC36473.1 - 0.022 15.1 0.0 0.1 12.9 0.0 2.1 2 0 0 2 2 2 0 PAS fold DpaA_N PF16924.5 EFC36473.1 - 0.16 12.1 0.1 0.52 10.4 0.1 1.9 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain DnaJ PF00226.31 EFC36474.1 - 3.3e-08 33.5 0.8 0.00069 19.7 0.1 2.5 2 0 0 2 2 2 2 DnaJ domain Prominin PF05478.11 EFC36474.1 - 0.00078 17.6 1.7 0.00078 17.6 1.7 2.0 2 0 0 2 2 2 1 Prominin DUF2207 PF09972.9 EFC36474.1 - 0.0027 16.6 0.2 0.0034 16.2 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) SANT_DAMP1_like PF16282.5 EFC36474.1 - 0.013 15.7 0.8 0.27 11.4 0.1 2.5 1 1 0 2 2 2 0 SANT/Myb-like domain of DAMP1 DUF368 PF04018.13 EFC36474.1 - 0.013 15.1 0.2 0.017 14.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF368) SRR PF07709.11 EFC36474.1 - 0.051 14.0 0.1 8.4 7.3 0.0 2.6 2 0 0 2 2 2 0 Seven Residue Repeat DUF573 PF04504.14 EFC36474.1 - 0.051 14.2 0.7 0.14 12.9 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function, DUF573 Baculo_F PF12259.8 EFC36474.1 - 0.066 11.7 2.8 0.1 11.1 2.0 1.6 1 1 0 1 1 1 0 Baculovirus F protein Sigma70_ner PF04546.13 EFC36474.1 - 0.088 12.7 3.3 1.2 9.0 3.3 2.0 1 1 0 1 1 1 0 Sigma-70, non-essential region ECSCR PF15820.5 EFC36474.1 - 0.15 11.9 1.1 0.22 11.4 0.5 1.6 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator SLATT_5 PF18160.1 EFC36474.1 - 0.39 10.0 3.2 1 8.7 1.6 2.0 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 LSR PF05624.14 EFC36474.1 - 1.2 9.2 5.3 2.3 8.3 5.3 1.5 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) DUF4006 PF13179.6 EFC36474.1 - 7 6.6 10.7 4.2 7.3 0.0 3.2 3 1 0 3 3 3 0 Family of unknown function (DUF4006) Mito_carr PF00153.27 EFC36475.1 - 1.7e-34 117.6 1.2 1.1e-13 50.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein YchF-GTPase_C PF06071.13 EFC36476.1 - 5.2e-35 119.5 0.2 5.2e-35 119.5 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFC36476.1 - 5.1e-22 78.1 0.0 1e-21 77.1 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC36476.1 - 6.7e-07 29.0 0.0 2.2e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 EFC36476.1 - 0.02 13.9 0.0 0.046 12.7 0.0 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFC36476.1 - 0.086 13.4 0.0 2.1 8.9 0.0 2.3 2 0 0 2 2 2 0 ABC transporter ATP-synt_G PF04718.15 EFC36476.1 - 0.12 13.2 0.1 8 7.4 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial ATP synthase g subunit PAS PF00989.25 EFC36477.1 - 3.3e-12 46.4 0.0 2.2e-08 34.1 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC36477.1 - 2.4e-10 40.6 1.1 5.1e-07 29.9 0.2 3.0 3 0 0 3 3 3 2 PAS domain Cellulase PF00150.18 EFC36477.1 - 4.3e-07 29.7 0.0 9.4e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PAS_4 PF08448.10 EFC36477.1 - 6.8e-07 29.5 0.0 0.00081 19.6 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_10 PF13596.6 EFC36477.1 - 0.0019 18.7 0.2 0.079 13.6 0.2 3.1 3 0 0 3 3 3 1 PAS domain PAS_8 PF13188.7 EFC36477.1 - 0.0067 16.4 0.0 1.3 9.2 0.0 3.1 2 1 1 3 3 3 1 PAS domain Pkinase PF00069.25 EFC36479.1 - 5.8e-62 209.4 0.0 1.1e-61 208.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36479.1 - 5.2e-39 134.1 0.0 9.1e-39 133.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC36479.1 - 0.00011 21.2 4.8 0.00097 18.0 4.8 2.1 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC36479.1 - 0.0032 17.4 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC36479.1 - 0.0033 16.8 0.0 0.028 13.7 0.0 2.2 1 1 0 1 1 1 1 Kinase-like FtsH_ext PF06480.15 EFC36479.1 - 4.7 7.6 7.5 2.1 8.7 3.7 2.3 2 0 0 2 2 2 0 FtsH Extracellular Guanylate_cyc PF00211.20 EFC36482.1 - 5e-05 23.0 0.0 7.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Guanylate_cyc PF00211.20 EFC36483.1 - 2.1e-58 196.9 0.1 5.1e-58 195.7 0.1 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC36483.1 - 2.4e-15 56.6 0.1 1.4e-14 54.1 0.1 2.5 1 0 0 1 1 1 1 PAS domain DUF3267 PF11667.8 EFC36483.1 - 2.8e-05 24.3 2.6 0.043 14.1 0.1 3.4 3 0 0 3 3 3 2 Putative zincin peptidase PAS PF00989.25 EFC36483.1 - 0.0001 22.3 0.0 0.00032 20.7 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC36483.1 - 0.0022 18.0 0.0 0.0089 16.0 0.0 2.0 2 0 0 2 2 1 1 PAS domain PHA_synth_III_E PF09712.10 EFC36483.1 - 0.0039 16.3 9.7 0.098 11.7 1.3 3.3 2 1 1 3 3 3 2 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) DUF4711 PF15829.5 EFC36483.1 - 0.009 16.0 4.2 0.97 9.3 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4711) PAS_4 PF08448.10 EFC36483.1 - 0.018 15.3 0.0 0.054 13.7 0.0 1.8 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC36483.1 - 0.022 14.2 0.1 0.022 14.2 0.1 3.2 3 1 1 4 4 4 0 Heme NO binding associated Armet PF10208.9 EFC36483.1 - 0.035 14.1 10.3 7.4 6.5 0.3 4.2 3 1 1 4 4 4 0 Degradation arginine-rich protein for mis-folding Sigma70_r4_2 PF08281.12 EFC36483.1 - 0.14 11.9 1.1 14 5.4 0.1 2.5 2 0 0 2 2 2 0 Sigma-70, region 4 GIT1_C PF12205.8 EFC36483.1 - 0.23 11.6 3.5 1.3 9.1 0.4 3.0 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Cep57_MT_bd PF06657.13 EFC36483.1 - 0.68 10.4 5.9 9 6.8 0.2 3.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Baculo_11_kDa PF06143.11 EFC36483.1 - 2.1 8.0 10.7 2.9 7.5 2.7 4.1 3 0 0 3 3 3 0 Baculovirus 11 kDa family PMC2NT PF08066.12 EFC36483.1 - 8.7 7.1 15.6 33 5.2 0.1 5.1 4 0 0 4 4 4 0 PMC2NT (NUC016) domain DUF599 PF04654.12 EFC36484.1 - 0.037 13.5 0.3 0.054 12.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Wzz PF02706.15 EFC36486.1 - 1.1 9.7 3.0 16 5.9 0.0 2.6 2 0 0 2 2 2 0 Chain length determinant protein DUF4116 PF13475.6 EFC36487.1 - 2e-06 27.4 0.7 2e-06 27.4 0.7 6.8 8 1 0 8 8 8 2 Domain of unknown function (DUF4116) HSP70 PF00012.20 EFC36488.1 - 9.1e-262 869.6 10.3 1e-261 869.4 10.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC36488.1 - 4.5e-18 65.1 0.3 1.7e-16 60.0 0.1 2.3 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC36488.1 - 0.00082 18.7 0.2 0.02 14.2 0.1 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase DDR PF08841.10 EFC36488.1 - 0.0082 15.2 0.1 0.39 9.6 0.1 2.3 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain kleA_kleC PF17383.2 EFC36488.1 - 0.064 13.6 1.0 0.55 10.6 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A FtsA PF14450.6 EFC36488.1 - 0.16 12.4 6.1 21 5.6 0.2 3.6 3 2 0 3 3 3 0 Cell division protein FtsA DUF4407 PF14362.6 EFC36488.1 - 2.7 7.2 5.8 5.3 6.3 5.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1837 PF08878.11 EFC36489.1 - 0.00014 21.7 0.1 0.0063 16.3 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF1837) PGK PF00162.19 EFC36489.1 - 0.015 14.3 0.1 0.018 14.0 0.1 1.1 1 0 0 1 1 1 0 Phosphoglycerate kinase AHH PF14412.6 EFC36489.1 - 0.034 14.2 0.1 0.044 13.9 0.1 1.2 1 0 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH V-SNARE PF05008.15 EFC36490.1 - 0.035 14.5 16.0 0.89 10.0 0.2 3.2 1 1 2 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF3450 PF11932.8 EFC36490.1 - 0.1 11.9 8.1 6.1 6.1 7.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 EFC36490.1 - 0.11 11.8 1.8 0.17 11.2 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EFC36490.1 - 0.3 10.9 9.6 0.41 10.5 7.8 2.2 1 1 1 2 2 2 0 Septum formation initiator HIP1_clath_bdg PF16515.5 EFC36490.1 - 0.41 11.3 13.7 0.081 13.5 9.0 2.0 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2203 PF09969.9 EFC36490.1 - 0.49 11.1 7.4 0.27 12.0 5.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4047 PF13256.6 EFC36490.1 - 6.8 6.9 9.4 35 4.6 6.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Exonuc_VII_L PF02601.15 EFC36490.1 - 9.2 5.7 14.0 36 3.8 14.0 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit Pkinase PF00069.25 EFC36491.1 - 8e-26 91.0 2.2 8e-26 91.0 2.2 3.5 3 2 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36491.1 - 5.3e-23 81.6 0.7 4.4e-22 78.6 0.3 2.6 2 0 0 2 2 2 1 Protein tyrosine kinase Dynamin_N PF00350.23 EFC36491.1 - 1.4e-16 61.0 3.8 2.4e-16 60.2 0.7 3.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFC36491.1 - 1.3e-10 41.4 3.4 1.7e-10 41.0 1.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Arf PF00025.21 EFC36491.1 - 0.00041 19.8 0.2 1.1 8.6 0.0 2.7 2 0 0 2 2 2 2 ADP-ribosylation factor family ABC_tran PF00005.27 EFC36491.1 - 0.00043 20.8 3.0 0.0043 17.6 0.1 3.4 2 0 0 2 2 2 1 ABC transporter Pkinase_fungal PF17667.1 EFC36491.1 - 0.0016 17.3 0.1 0.005 15.7 0.1 1.8 1 0 0 1 1 1 1 Fungal protein kinase FeoB_N PF02421.18 EFC36491.1 - 0.0042 16.6 0.0 0.0042 16.6 0.0 3.3 4 0 0 4 4 4 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFC36491.1 - 0.013 15.0 6.6 0.77 9.3 0.4 4.3 3 2 0 3 3 3 0 Elongation factor Tu GTP binding domain T2SSE PF00437.20 EFC36491.1 - 0.033 13.3 0.4 0.19 10.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein IBR PF01485.21 EFC36491.1 - 0.1 12.8 5.0 0.45 10.8 5.0 2.1 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain efb-c PF12199.8 EFC36491.1 - 0.23 11.5 3.8 0.33 11.0 0.7 2.9 2 0 0 2 2 2 0 Extracellular fibrinogen binding protein C terminal PduV-EutP PF10662.9 EFC36491.1 - 1.1 9.0 6.0 8.6 6.1 0.1 4.0 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 EFC36491.1 - 2 8.7 6.9 12 6.2 0.0 3.9 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase Phage_integrase PF00589.22 EFC36492.1 - 0.00011 22.0 0.0 0.00024 21.0 0.0 1.5 1 1 0 1 1 1 1 Phage integrase family AMP-binding PF00501.28 EFC36493.1 - 4e-54 183.8 0.0 3.9e-52 177.3 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme CH PF00307.31 EFC36494.1 - 0.17 12.1 0.0 0.39 10.9 0.0 1.6 1 0 0 1 1 1 0 Calponin homology (CH) domain LRR_6 PF13516.6 EFC36495.1 - 3.4e-36 120.2 4.1 0.0004 20.2 0.0 7.4 7 0 0 7 7 7 7 Leucine Rich repeat LRR_8 PF13855.6 EFC36495.1 - 2e-21 75.5 10.3 2.6e-07 30.3 0.2 4.4 2 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC36495.1 - 5.5e-17 61.6 11.7 0.00018 21.9 0.2 5.7 2 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36495.1 - 1.3e-10 40.3 1.7 2.4 9.0 0.0 7.9 8 0 0 8 8 8 1 Leucine Rich Repeat DUF3707 PF12499.8 EFC36495.1 - 0.12 12.9 0.0 6.6 7.3 0.0 2.5 1 1 1 2 2 2 0 Pherophorin ApoB100_C PF12491.8 EFC36495.1 - 0.12 12.4 12.7 15 5.6 0.1 6.5 2 2 5 7 7 7 0 Apolipoprotein B100 C terminal LRR_6 PF13516.6 EFC36496.1 - 1.5e-25 87.0 0.3 2.4e-06 27.2 0.0 4.3 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 EFC36496.1 - 2.1e-18 66.1 12.4 1.6e-06 28.3 0.2 3.1 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36496.1 - 1.6e-11 43.7 4.9 3.6e-07 29.8 0.3 2.2 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFC36496.1 - 8.9e-08 31.7 0.1 2.4 9.0 0.0 4.4 5 0 0 5 5 5 2 Leucine Rich Repeat ApoB100_C PF12491.8 EFC36496.1 - 0.00014 21.8 2.8 8.4 6.4 0.1 4.0 1 1 3 4 4 4 3 Apolipoprotein B100 C terminal LRR_9 PF14580.6 EFC36496.1 - 0.00026 20.5 2.1 0.003 17.1 0.3 2.0 1 1 1 2 2 2 2 Leucine-rich repeat DUF4347 PF14252.6 EFC36496.1 - 0.0029 17.5 0.2 2.3 8.0 0.0 3.0 1 1 2 3 3 3 2 Domain of unknown function (DUF4347) NKWYS PF10364.9 EFC36496.1 - 0.0079 16.3 0.7 2.2 8.4 0.1 2.5 1 1 1 2 2 2 2 Putative capsular polysaccharide synthesis protein UPF0193 PF05250.11 EFC36496.1 - 0.028 14.2 2.6 1.3 8.8 0.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0193) CLU_N PF15044.6 EFC36496.1 - 0.048 14.0 2.8 2.6 8.5 0.1 2.9 1 1 2 3 3 3 0 Mitochondrial function, CLU-N-term NHL PF01436.21 EFC36497.1 - 3e-62 203.7 0.0 3.5e-08 33.1 0.0 11.8 12 0 0 12 12 12 9 NHL repeat SGL PF08450.12 EFC36497.1 - 3.3e-18 66.2 0.7 1.7e-06 27.8 0.0 5.5 2 2 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC36497.1 - 5.2e-08 33.0 8.8 4.1 7.7 0.0 8.1 8 1 1 9 9 9 3 Arylesterase SBBP PF06739.11 EFC36497.1 - 7.5e-07 29.0 14.6 0.0047 16.9 0.0 7.0 7 0 0 7 7 7 3 Beta-propeller repeat Phytase-like PF13449.6 EFC36497.1 - 2.3e-06 27.8 1.7 0.95 9.3 0.0 6.1 4 2 2 6 6 6 2 Esterase-like activity of phytase Ldl_recept_b PF00058.17 EFC36497.1 - 0.00016 22.1 6.9 1.1 9.9 0.0 8.0 10 1 0 10 10 10 1 Low-density lipoprotein receptor repeat class B SdiA-regulated PF06977.11 EFC36497.1 - 0.52 9.5 2.6 18 4.5 0.0 4.4 8 0 0 8 8 8 0 SdiA-regulated F-box PF00646.33 EFC36499.1 - 0.03 14.2 1.4 0.051 13.5 0.1 2.1 2 0 0 2 2 2 0 F-box domain SpoIIM PF01944.17 EFC36499.1 - 0.58 10.2 10.1 1 9.4 10.1 1.3 1 0 0 1 1 1 0 Stage II sporulation protein M Synaptobrevin PF00957.21 EFC36501.1 - 6.1e-25 86.8 4.6 1.7e-24 85.4 4.6 1.9 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFC36501.1 - 3e-09 36.8 0.0 9.5e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_UL14 PF03580.14 EFC36501.1 - 0.0037 17.5 2.2 2.5 8.4 0.0 3.6 3 0 0 3 3 3 1 Herpesvirus UL14-like protein Pex24p PF06398.11 EFC36501.1 - 0.032 13.2 0.9 0.055 12.4 0.9 1.4 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin RIFIN PF02009.16 EFC36501.1 - 0.057 13.3 9.0 0.028 14.3 4.5 2.3 2 0 0 2 2 2 0 Rifin DUF5383 PF17355.2 EFC36501.1 - 0.18 12.2 11.1 3.5 8.0 0.6 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5383) GP41 PF00517.17 EFC36501.1 - 0.34 10.8 4.1 0.42 10.5 0.3 2.8 3 0 0 3 3 3 0 Retroviral envelope protein DUF848 PF05852.11 EFC36501.1 - 4.7 7.3 9.2 7.6 6.6 0.6 3.2 3 0 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) PDEase_I PF00233.19 EFC36502.1 - 3.4e-83 279.0 1.4 3.4e-83 279.0 1.4 2.8 3 0 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.24 EFC36502.1 - 5.7e-30 103.8 2.4 2.4e-28 98.5 0.2 3.1 3 0 0 3 3 3 1 Response regulator receiver domain Mucin PF01456.17 EFC36502.1 - 0.0031 17.5 15.3 0.0031 17.5 15.3 2.0 2 0 0 2 2 2 1 Mucin-like glycoprotein FleQ PF06490.11 EFC36502.1 - 0.0079 16.6 0.1 0.045 14.1 0.1 2.4 2 0 0 2 2 2 1 Flagellar regulatory protein FleQ HD PF01966.22 EFC36502.1 - 0.032 14.5 0.1 0.094 12.9 0.1 1.8 1 0 0 1 1 1 0 HD domain PYRIN PF02758.16 EFC36502.1 - 0.038 14.1 2.3 8.6 6.6 0.3 2.9 2 0 0 2 2 2 0 PAAD/DAPIN/Pyrin domain DUF3450 PF11932.8 EFC36502.1 - 1.3 8.2 8.3 0.58 9.4 3.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Pex14_N PF04695.13 EFC36502.1 - 1.7 9.3 9.2 2.9 8.6 0.9 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Gemini_AL1_M PF08283.11 EFC36503.1 - 0.54 10.4 2.2 14 5.8 0.1 3.5 4 0 0 4 4 4 0 Geminivirus rep protein central domain ABC_membrane PF00664.23 EFC36504.1 - 3.4e-57 194.2 4.1 4.5e-57 193.8 4.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC36504.1 - 6.1e-35 120.7 0.1 3.4e-34 118.3 0.0 2.2 3 0 0 3 3 2 1 ABC transporter AAA_23 PF13476.6 EFC36504.1 - 0.00026 21.6 0.6 0.021 15.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 EFC36504.1 - 0.00035 20.4 2.8 0.0013 18.6 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 EFC36504.1 - 0.0011 18.6 0.1 0.0032 17.2 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC36504.1 - 0.012 15.5 0.1 0.05 13.5 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase NB-ARC PF00931.22 EFC36504.1 - 0.016 14.4 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EFC36504.1 - 0.017 14.4 0.0 0.041 13.2 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_21 PF13304.6 EFC36504.1 - 0.021 14.6 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EFC36504.1 - 0.022 14.9 0.1 0.22 11.6 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_16 PF13191.6 EFC36504.1 - 0.036 14.5 0.0 0.073 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFC36504.1 - 0.059 13.9 0.0 0.17 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFC36504.1 - 0.089 12.5 0.0 0.25 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFC36504.1 - 0.096 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_24 PF13479.6 EFC36504.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFC36504.1 - 0.13 12.4 0.1 0.57 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC36504.1 - 0.14 12.5 0.0 0.63 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain CaATP_NAI PF12515.8 EFC36505.1 - 0.002 17.7 0.0 11 5.7 0.0 4.0 2 2 1 3 3 3 2 Ca2+-ATPase N terminal autoinhibitory domain DUF5058 PF16481.5 EFC36505.1 - 0.0097 15.6 0.4 0.022 14.5 0.3 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5058) FNIP_C PF14638.6 EFC36505.1 - 0.081 12.6 0.6 0.73 9.4 0.0 2.5 2 0 0 2 2 2 0 Folliculin-interacting protein C-terminus LIN52 PF10044.9 EFC36505.1 - 0.87 10.3 0.1 0.87 10.3 0.1 3.4 3 1 0 3 3 3 0 Retinal tissue protein DUF3632 PF12311.8 EFC36505.1 - 3.8 7.9 8.9 0.83 10.1 2.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3632) DUF4116 PF13475.6 EFC36506.1 - 3.2e-25 87.6 14.0 3.8e-09 36.1 0.0 6.3 3 2 2 6 6 6 4 Domain of unknown function (DUF4116) Rbsn PF11464.8 EFC36507.1 - 0.14 11.9 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Rabenosyn Rab binding domain DJ-1_PfpI PF01965.24 EFC36508.1 - 4e-06 26.7 0.1 2.8e-05 24.0 0.1 2.2 1 1 1 2 2 2 1 DJ-1/PfpI family LRR_4 PF12799.7 EFC36509.1 - 1.8e-17 63.1 15.4 0.00015 22.0 0.4 4.7 4 0 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC36509.1 - 3.7e-12 46.1 2.5 4.6e-06 26.2 0.9 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 EFC36509.1 - 1.2e-10 41.0 15.0 2.7e-09 36.6 7.0 4.3 3 2 1 4 4 4 1 Leucine rich repeat PNISR PF15996.5 EFC36509.1 - 0.0065 16.8 18.8 0.011 16.0 18.8 1.3 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR SAM_3 PF18016.1 EFC36509.1 - 0.012 15.4 0.6 0.17 11.7 0.1 2.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Peptidase_S46 PF10459.9 EFC36509.1 - 0.35 9.4 7.7 0.45 9.1 7.7 1.1 1 0 0 1 1 1 0 Peptidase S46 LRR_6 PF13516.6 EFC36509.1 - 1.4 9.2 17.0 3.4 8.0 1.4 4.3 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 EFC36509.1 - 2 9.3 13.4 2.1 9.2 0.4 5.3 4 2 0 4 4 4 0 Leucine Rich Repeat Presenilin PF01080.17 EFC36509.1 - 6.6 5.4 6.1 9.2 4.9 6.1 1.2 1 0 0 1 1 1 0 Presenilin MBOAT PF03062.19 EFC36510.1 - 2.9e-28 99.2 31.2 2.9e-28 99.2 31.2 2.0 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Tubulin PF00091.25 EFC36511.1 - 6.5e-70 235.4 0.0 1.2e-69 234.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC36511.1 - 3.6e-41 140.3 0.1 5.5e-41 139.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC36511.1 - 3.6e-05 24.1 0.0 9.8e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EFC36511.1 - 0.00063 19.0 0.0 0.0029 16.9 0.0 1.9 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EFC36511.1 - 0.0011 18.6 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain RRP7 PF12923.7 EFC36512.1 - 6.3e-23 81.2 17.4 6.3e-23 81.2 17.4 1.9 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Treacle PF03546.14 EFC36512.1 - 0.14 11.0 3.0 0.22 10.3 3.0 1.3 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle AAA PF00004.29 EFC36513.1 - 3.2e-43 147.3 0.0 9e-43 145.9 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFC36513.1 - 1.1e-27 95.8 0.0 8.1e-27 93.0 0.0 2.5 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 EFC36513.1 - 4.1e-19 68.4 1.6 1.2e-18 66.9 1.6 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 EFC36513.1 - 2.7e-09 36.7 0.0 2.1e-08 33.8 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain IstB_IS21 PF01695.17 EFC36513.1 - 1.9e-05 24.5 0.0 3.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 EFC36513.1 - 2.8e-05 24.2 0.0 0.00015 21.8 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC36513.1 - 2.9e-05 24.5 0.1 0.00027 21.4 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 EFC36513.1 - 3.3e-05 23.7 0.0 6.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFC36513.1 - 0.00015 21.1 0.0 0.00024 20.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 EFC36513.1 - 0.0002 21.5 0.4 0.001 19.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EFC36513.1 - 0.00023 21.2 0.0 0.0014 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 EFC36513.1 - 0.00031 20.0 0.0 0.00064 19.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFC36513.1 - 0.00038 20.7 1.4 0.0036 17.6 0.1 3.0 3 1 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 EFC36513.1 - 0.00081 19.8 0.0 0.0021 18.4 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 EFC36513.1 - 0.00093 19.7 1.0 0.002 18.7 0.0 2.1 3 0 0 3 3 1 1 AAA domain AAA_24 PF13479.6 EFC36513.1 - 0.0011 18.8 0.0 0.0033 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFC36513.1 - 0.005 17.3 2.2 0.015 15.7 0.0 2.5 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 EFC36513.1 - 0.0084 16.3 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 EFC36513.1 - 0.016 14.4 0.5 1.9 7.6 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EFC36513.1 - 0.019 14.4 0.0 0.11 11.9 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 EFC36513.1 - 0.033 13.7 0.0 0.16 11.5 0.0 2.1 2 1 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 EFC36513.1 - 0.034 13.5 0.0 0.078 12.3 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EFC36513.1 - 0.041 13.4 0.4 0.78 9.3 0.1 2.6 2 1 0 3 3 2 0 AAA domain Parvo_NS1 PF01057.17 EFC36513.1 - 0.06 12.4 0.0 0.096 11.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 EFC36513.1 - 0.074 13.0 0.0 0.73 9.7 0.0 2.2 1 1 1 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 EFC36513.1 - 0.11 12.1 0.0 0.62 9.8 0.0 2.0 1 1 1 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EFC36513.1 - 0.14 11.8 0.0 0.42 10.3 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EFC36513.1 - 0.57 9.9 3.7 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain ALMT PF11744.8 EFC36513.1 - 1.6 7.5 3.1 2.2 7.0 3.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter ATPase_2 PF01637.18 EFC36513.1 - 2 8.3 0.0 2 8.3 0.0 3.0 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea Ku_C PF03730.14 EFC36513.1 - 3.6 8.4 6.4 4.2 8.1 5.0 1.9 2 0 0 2 2 1 0 Ku70/Ku80 C-terminal arm LRR_6 PF13516.6 EFC36514.1 - 4.4e-18 63.7 47.6 0.0025 17.7 0.0 13.4 14 0 0 14 14 14 8 Leucine Rich repeat LRR_4 PF12799.7 EFC36514.1 - 1.5e-13 50.7 70.5 0.012 16.0 2.5 10.4 5 2 0 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36514.1 - 4.6e-05 23.1 56.2 0.0012 18.6 9.5 10.1 5 4 3 8 8 8 5 Leucine rich repeat LRR_1 PF00560.33 EFC36514.1 - 0.2 12.3 56.5 0.52 11.1 0.1 13.5 14 2 0 14 14 14 0 Leucine Rich Repeat CTD_bind PF04818.13 EFC36516.1 - 0.091 13.6 0.4 0.091 13.6 0.4 1.7 2 0 0 2 2 2 0 RNA polymerase II-binding domain. NHL PF01436.21 EFC36517.1 - 5e-17 61.0 5.4 1.5e-05 24.8 0.1 4.9 4 0 0 4 4 4 3 NHL repeat BTB PF00651.31 EFC36517.1 - 2.2e-09 37.5 0.4 2.2e-09 37.5 0.4 2.7 4 0 0 4 4 4 1 BTB/POZ domain Linker_histone PF00538.19 EFC36517.1 - 6.3e-05 23.3 5.7 4.1 7.8 0.0 5.5 4 2 2 6 6 6 2 linker histone H1 and H5 family PCMT PF01135.19 EFC36517.1 - 0.095 12.4 1.4 4.8 6.9 0.0 3.8 5 1 1 6 6 6 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3420 PF11900.8 EFC36517.1 - 0.33 11.1 4.3 98 3.2 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3420) ATP-synt_10 PF05176.14 EFC36518.1 - 3.4e-31 108.4 5.4 4.4e-31 108.0 5.4 1.2 1 0 0 1 1 1 1 ATP10 protein MbeD_MobD PF04899.12 EFC36518.1 - 0.063 13.4 0.1 0.19 11.9 0.1 1.8 1 0 0 1 1 1 0 MbeD/MobD like Pex19 PF04614.12 EFC36519.1 - 3.5e-30 105.6 21.5 2.7e-28 99.4 21.5 2.9 1 1 0 1 1 1 1 Pex19 protein family IL15 PF02372.15 EFC36519.1 - 0.00058 19.9 3.5 0.37 10.8 0.3 2.4 2 0 0 2 2 2 2 Interleukin 15 DNA_gyraseB PF00204.25 EFC36519.1 - 0.017 14.6 0.6 0.034 13.6 0.6 1.5 1 0 0 1 1 1 0 DNA gyrase B dbPDZ_assoc PF16610.5 EFC36519.1 - 0.034 14.4 7.0 0.27 11.5 0.8 2.8 2 1 1 3 3 3 0 Unstructured region between two PDZ domains on Dlg5 Vps53_N PF04100.12 EFC36519.1 - 0.065 12.2 2.2 0.2 10.6 0.1 2.1 2 0 0 2 2 2 0 Vps53-like, N-terminal DUF3446 PF11928.8 EFC36519.1 - 0.076 13.3 4.9 0.24 11.7 0.8 2.6 3 0 0 3 3 3 0 Early growth response N-terminal domain PHA_synth_III_E PF09712.10 EFC36519.1 - 0.1 11.6 2.5 0.19 10.8 0.8 2.0 1 1 0 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) CD99L2 PF12301.8 EFC36519.1 - 0.62 10.3 6.1 0.34 11.2 3.6 1.8 2 0 0 2 2 2 0 CD99 antigen like protein 2 Occludin_ELL PF07303.13 EFC36519.1 - 3.5 8.4 5.2 8.6 7.2 0.1 3.2 3 1 1 4 4 4 0 Occludin homology domain Peptidase_M16 PF00675.20 EFC36520.1 - 2.5e-35 121.7 0.3 5.2e-35 120.6 0.1 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFC36520.1 - 3.7e-17 62.9 0.1 6.6e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Methyltr_RsmB-F PF01189.17 EFC36521.1 - 8.6e-34 116.9 0.0 1.8e-33 115.9 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 EFC36521.1 - 3.3e-09 36.7 0.0 6.9e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC36521.1 - 3.3e-06 27.7 0.0 8.3e-06 26.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC36521.1 - 0.00032 20.1 0.0 0.00079 18.8 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF4065 PF13274.6 EFC36521.1 - 1.5 9.8 7.5 15 6.5 1.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4065) RNA_ligase PF09414.10 EFC36524.1 - 5.6e-29 101.5 0.0 9.8e-29 100.7 0.0 1.4 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_M PF01068.21 EFC36524.1 - 0.015 14.9 0.2 0.13 11.9 0.2 2.3 1 1 0 1 1 1 0 ATP dependent DNA ligase domain AHJR-like PF18743.1 EFC36524.1 - 0.07 12.7 0.0 5.7 6.5 0.0 2.2 2 0 0 2 2 2 0 REase_AHJR-like RNA_lig_T4_1 PF09511.10 EFC36524.1 - 0.086 12.7 0.0 0.16 11.8 0.0 1.4 1 1 0 1 1 1 0 RNA ligase C2 PF00168.30 EFC36525.1 - 5.5e-16 58.7 0.0 1.3e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain HMG_box PF00505.19 EFC36526.1 - 4.4e-33 113.5 18.6 4.2e-16 59.1 7.0 3.9 3 0 0 3 3 3 3 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC36526.1 - 4.8e-21 75.1 20.5 1.4e-10 41.6 0.7 3.7 2 1 1 3 3 3 3 HMG-box domain CHDNT PF08073.12 EFC36526.1 - 0.011 15.7 2.9 0.053 13.5 0.2 3.0 3 0 0 3 3 3 0 CHDNT (NUC034) domain SAM_Exu PF18609.1 EFC36526.1 - 0.41 10.8 3.2 2 8.6 1.8 2.5 2 0 0 2 2 2 0 Exuperantia SAM-like domain KfrA_N PF11740.8 EFC36526.1 - 3.5 8.3 6.5 1.7 9.4 0.9 2.8 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Pkinase_Tyr PF07714.17 EFC36527.1 - 0.00056 19.3 0.0 0.00061 19.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC36528.1 - 7.7e-29 100.8 0.1 7.1e-28 97.7 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36528.1 - 5.4e-28 98.0 0.1 2.5e-26 92.5 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase LapA_dom PF06305.11 EFC36528.1 - 0.0013 18.5 1.9 0.0026 17.5 1.9 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain Actin PF00022.19 EFC36529.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin LRR_4 PF12799.7 EFC36530.1 - 3.5e-05 24.1 37.4 0.0057 17.0 4.5 7.4 7 1 0 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC36530.1 - 0.04 14.0 11.7 9.3 6.6 1.1 6.3 6 0 0 6 6 6 0 Leucine Rich repeat FTH PF01827.27 EFC36530.1 - 0.15 11.8 11.9 0.023 14.5 4.4 3.2 3 1 0 3 3 3 0 FTH domain DUF4116 PF13475.6 EFC36531.1 - 1.4e-26 92.0 8.0 6.6e-05 22.6 0.0 5.7 4 1 2 6 6 6 6 Domain of unknown function (DUF4116) RPN13_C PF16550.5 EFC36531.1 - 0.049 13.8 0.8 0.45 10.7 0.0 2.6 2 1 0 3 3 3 0 UCH-binding domain DndB PF14072.6 EFC36532.1 - 0.0047 16.2 1.6 0.008 15.4 0.5 1.9 2 1 0 2 2 2 1 DNA-sulfur modification-associated Dsl1_C PF11989.8 EFC36532.1 - 0.0068 16.1 5.4 0.76 9.5 0.2 3.9 3 1 1 4 4 4 1 Retrograde transport protein Dsl1 C terminal Plasmid_RAQPRD PF09686.10 EFC36532.1 - 0.008 16.4 0.0 6.2 7.1 0.0 4.0 5 0 0 5 5 5 1 Plasmid protein of unknown function (Plasmid_RAQPRD) Pex2_Pex12 PF04757.14 EFC36532.1 - 0.012 15.3 2.7 0.27 10.8 0.1 3.4 2 2 0 2 2 2 0 Pex2 / Pex12 amino terminal region COMPASS-Shg1 PF05205.12 EFC36532.1 - 0.39 11.4 3.2 3.1 8.6 0.1 3.3 2 1 1 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 IBN_N PF03810.19 EFC36532.1 - 0.8 9.7 10.3 4.4 7.3 0.2 5.3 5 1 1 6 6 6 0 Importin-beta N-terminal domain Taeniidae_ag PF05596.11 EFC36532.1 - 1.6 8.7 5.6 1.6 8.8 0.1 3.8 5 0 0 5 5 5 0 Taeniidae antigen MKT1_C PF12246.8 EFC36532.1 - 3.3 6.9 7.4 1.6 7.9 0.8 2.9 3 1 0 3 3 3 0 Temperature dependent protein affecting M2 dsRNA replication RhoGAP PF00620.27 EFC36533.1 - 1.1e-29 103.2 0.2 1.1e-29 103.2 0.2 2.6 2 1 0 2 2 2 1 RhoGAP domain VIT1 PF01988.19 EFC36533.1 - 0.045 13.6 2.3 0.061 13.2 1.4 1.6 2 0 0 2 2 2 0 VIT family Peptidase_S8 PF00082.22 EFC36534.1 - 5.3e-49 167.1 4.5 2.2e-48 165.1 3.6 2.0 2 0 0 2 2 2 1 Subtilase family SWIRM-assoc_1 PF16495.5 EFC36534.1 - 0.022 14.7 0.1 0.059 13.3 0.1 1.6 1 0 0 1 1 1 0 SWIRM-associated region 1 DUF2615 PF11027.8 EFC36534.1 - 1.2 9.3 5.7 3.1 8.0 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) EGF_2 PF07974.13 EFC36534.1 - 1.2 9.5 21.6 1.9 8.9 2.1 2.8 2 0 0 2 2 2 0 EGF-like domain WD40 PF00400.32 EFC36536.1 - 1.2e-13 51.3 16.3 5.8e-05 23.8 0.1 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36536.1 - 2.1e-11 43.9 1.6 5.6e-07 29.8 0.3 3.0 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC36536.1 - 1.2e-05 24.5 0.0 0.066 12.2 0.0 2.7 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ACC_central PF08326.12 EFC36537.1 - 1.1e-173 579.4 7.5 1.6e-173 578.8 7.5 1.3 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 EFC36537.1 - 5.8e-158 526.6 0.1 7.9e-158 526.1 0.1 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 EFC36537.1 - 7.1e-50 169.4 0.2 2.3e-49 167.8 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFC36537.1 - 6.8e-29 100.6 0.0 1.7e-28 99.3 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFC36537.1 - 2.6e-22 79.0 0.0 8.5e-22 77.3 0.0 2.0 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFC36537.1 - 3.5e-11 42.8 0.0 1.4e-10 40.8 0.0 2.1 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 EFC36537.1 - 2.1e-07 31.2 0.2 1.5e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.22 EFC36537.1 - 0.0002 21.0 0.0 0.00068 19.2 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EFC36537.1 - 0.00049 19.9 0.0 0.012 15.4 0.1 2.7 1 1 1 2 2 2 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EFC36537.1 - 0.00098 18.7 0.0 0.0032 17.0 0.0 1.9 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus GCV_H PF01597.19 EFC36537.1 - 0.056 13.3 0.0 0.65 9.9 0.0 2.6 2 0 0 2 2 2 0 Glycine cleavage H-protein Bcr-Abl_Oligo PF09036.10 EFC36538.1 - 0.045 13.8 0.4 0.48 10.5 0.0 2.8 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain TFIIE_alpha PF02002.17 EFC36538.1 - 0.067 13.1 2.0 0.15 12.0 0.2 2.6 2 0 0 2 2 2 0 TFIIE alpha subunit Apolipoprotein PF01442.18 EFC36538.1 - 0.16 11.8 6.1 1.7 8.5 0.0 3.4 4 0 0 4 4 4 0 Apolipoprotein A1/A4/E domain PilJ PF13675.6 EFC36538.1 - 0.21 11.6 1.5 1.7 8.7 0.0 2.9 3 0 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Spore_III_AB PF09548.10 EFC36538.1 - 0.57 10.3 5.2 0.22 11.6 1.3 2.4 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) CheZ PF04344.13 EFC36538.1 - 1.9 8.3 11.2 0.7 9.8 4.9 3.1 2 1 0 2 2 2 0 Chemotaxis phosphatase, CheZ NPV_P10 PF05531.12 EFC36538.1 - 7.7 7.1 14.3 4.7 7.7 1.1 4.2 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Abhydrolase_2 PF02230.16 EFC36539.1 - 2.9e-40 138.4 2.5 5e-40 137.6 0.0 2.5 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 EFC36539.1 - 8.5e-06 25.6 0.0 2.4e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Lipase_3 PF01764.25 EFC36539.1 - 7e-05 22.7 0.1 0.00028 20.8 0.0 2.1 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 EFC36539.1 - 0.00052 19.4 0.8 0.32 10.2 0.0 2.9 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC36539.1 - 0.0012 18.4 0.1 0.79 9.2 0.0 2.4 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 EFC36539.1 - 0.012 15.1 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family HATPase_c PF02518.26 EFC36540.1 - 6.2e-24 84.7 0.3 6.2e-24 84.7 0.3 2.6 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC36540.1 - 3.8e-10 39.9 0.3 1.7e-09 37.9 0.0 2.3 2 1 1 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 EFC36540.1 - 1.2e-09 38.1 0.1 6e-09 35.8 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_8 PF13188.7 EFC36540.1 - 1.6e-06 28.0 0.0 4.5e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EFC36540.1 - 9.8e-06 25.8 0.1 5e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_12 PF18095.1 EFC36540.1 - 0.00036 20.2 0.1 0.0011 18.6 0.1 1.8 1 0 0 1 1 1 1 UPF0242 C-terminal PAS-like domain PAS PF00989.25 EFC36540.1 - 0.00076 19.5 0.0 0.002 18.1 0.0 1.7 1 0 0 1 1 1 1 PAS fold DUF3484 PF11983.8 EFC36541.1 - 0.69 11.1 7.8 7.2 7.8 7.8 2.1 1 1 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch ABC2_membrane_3 PF12698.7 EFC36542.1 - 0.056 12.6 0.0 0.095 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein Wzz PF02706.15 EFC36542.1 - 0.11 12.8 0.0 0.44 10.9 0.0 2.0 1 0 0 1 1 1 0 Chain length determinant protein VCBS PF13517.6 EFC36543.1 - 1.7e-05 25.3 1.4 0.3 11.7 0.0 3.3 3 0 0 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFC36543.1 - 0.00091 19.3 1.6 0.32 11.2 0.0 2.7 2 0 0 2 2 2 2 FG-GAP repeat PQQ PF01011.21 EFC36543.1 - 0.22 11.5 0.3 5 7.2 0.0 3.2 4 0 0 4 4 4 0 PQQ enzyme repeat Dockerin_1 PF00404.18 EFC36543.1 - 0.26 11.5 1.2 8 6.7 0.0 3.4 4 0 0 4 4 4 0 Dockerin type I domain FliE PF02049.18 EFC36544.1 - 0.027 14.6 1.0 0.027 14.6 1.0 2.7 1 1 2 3 3 3 0 Flagellar hook-basal body complex protein FliE NAD_binding_4 PF07993.12 EFC36545.1 - 1.2e-48 165.6 0.0 2e-48 164.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EFC36545.1 - 1.8e-29 102.6 0.0 2.8e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EFC36545.1 - 7.6e-13 48.5 0.0 1.7e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC36545.1 - 1.4e-12 47.2 0.0 3.5e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 EFC36545.1 - 4e-11 43.1 0.1 2.4e-09 37.4 0.0 2.5 2 0 0 2 2 2 1 Phosphopantetheine attachment site ERAP1_C PF11838.8 EFC36545.1 - 0.082 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 ERAP1-like C-terminal domain DNA_alkylation PF08713.11 EFC36546.1 - 4.4e-40 137.7 0.2 5.3e-40 137.4 0.2 1.1 1 0 0 1 1 1 1 DNA alkylation repair enzyme Rab5-bind PF09311.11 EFC36546.1 - 0.081 12.3 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Rabaptin-like protein DUF4116 PF13475.6 EFC36547.1 - 2.8e-85 279.9 49.6 2.8e-13 49.4 0.0 14.5 6 6 8 15 15 15 15 Domain of unknown function (DUF4116) Phage_30_8 PF06019.11 EFC36548.1 - 0.062 13.2 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Phage GP30.8 protein DUF533 PF04391.12 EFC36549.1 - 0.093 12.3 0.4 0.13 11.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) DUF5065 PF16723.5 EFC36549.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5065) B12D PF06522.11 EFC36549.1 - 7 6.5 5.5 2.7 7.9 0.1 2.4 2 1 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit RGS PF00615.19 EFC36551.1 - 6e-06 26.5 5.0 8.3e-06 26.1 5.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain YhfZ_C PF14503.6 EFC36552.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 YhfZ C-terminal domain Cofilin_ADF PF00241.20 EFC36553.1 - 6.2e-16 58.3 0.0 7.1e-16 58.1 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Cyclase PF04199.13 EFC36554.1 - 1.8e-11 44.4 0.0 2.4e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 Putative cyclase TetR_C_13 PF16925.5 EFC36554.1 - 0.065 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain MDD_C PF18376.1 EFC36555.1 - 3.3e-69 232.4 1.2 5.1e-69 231.8 1.2 1.3 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 EFC36555.1 - 5.1e-07 29.8 2.2 1.2e-06 28.7 1.4 2.0 2 0 0 2 2 2 1 GHMP kinases N terminal domain MCM_lid PF17855.1 EFC36557.1 - 1.4e-09 38.3 0.8 2.5e-09 37.4 0.8 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM PF00493.23 EFC36558.1 - 1.5e-97 325.1 0.0 2e-97 324.7 0.0 1.1 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC36558.1 - 6.4e-20 71.3 3.8 1.1e-19 70.5 3.8 1.4 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 EFC36558.1 - 2.6e-09 36.8 0.1 2.2e-06 27.2 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFC36558.1 - 3.3e-06 27.1 0.0 1.4e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFC36558.1 - 0.00078 19.3 0.0 0.0032 17.3 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC36558.1 - 0.0071 16.1 0.0 0.32 10.7 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 EFC36558.1 - 0.0087 16.5 0.0 0.029 14.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain MCM_N PF14551.6 EFC36559.1 - 0.018 15.6 4.6 0.026 15.1 4.6 1.3 1 0 0 1 1 1 0 MCM N-terminal domain Rab_bind PF16704.5 EFC36559.1 - 0.039 14.0 0.2 0.64 10.1 0.0 2.2 1 1 1 2 2 2 0 Rab binding domain Peptidase_S10 PF00450.22 EFC36560.1 - 1.3e-21 77.5 2.2 7.7e-21 75.0 0.1 2.1 1 1 1 2 2 2 1 Serine carboxypeptidase EGF_2 PF07974.13 EFC36560.1 - 6.5e-05 23.2 11.7 0.00017 21.9 11.7 1.8 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFC36560.1 - 0.0048 17.2 9.1 0.0097 16.2 9.1 1.5 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 EFC36560.1 - 0.0099 16.5 2.1 0.025 15.2 2.1 1.8 1 0 0 1 1 1 1 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFC36560.1 - 0.045 13.8 5.6 0.096 12.8 5.6 1.6 1 0 0 1 1 1 0 Tenascin EGF domain EGF_alliinase PF04863.13 EFC36560.1 - 0.084 13.3 5.9 0.22 11.9 5.9 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain MBR1 PF17058.5 EFC36561.1 - 0.00025 21.4 6.5 0.00046 20.5 6.5 1.6 1 0 0 1 1 1 1 Mitochondrial biogenesis regulation protein 1 Trypan_PARP PF05887.11 EFC36562.1 - 3.8e-06 26.9 87.9 0.027 14.4 43.0 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) LRR_8 PF13855.6 EFC36563.1 - 0.0031 17.2 4.8 0.2 11.5 0.1 4.6 3 1 1 4 4 4 1 Leucine rich repeat Herpes_UL37_2 PF07413.11 EFC36563.1 - 0.15 11.3 2.6 0.99 8.6 0.0 2.8 4 0 0 4 4 4 0 Betaherpesvirus immediate-early glycoprotein UL37 LRR_4 PF12799.7 EFC36563.1 - 0.3 11.6 0.1 0.3 11.6 0.1 6.2 5 2 1 6 6 6 0 Leucine Rich repeats (2 copies) Zn_clus PF00172.18 EFC36564.1 - 1.6e-07 31.4 4.0 1.6e-07 31.4 4.0 2.2 1 1 1 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mitochondr_Som1 PF11093.8 EFC36564.1 - 0.72 9.9 6.4 1.1 9.3 6.4 1.5 1 1 0 1 1 1 0 Mitochondrial export protein Som1 TPT PF03151.16 EFC36566.1 - 1.1e-27 97.1 34.4 1.4e-27 96.8 34.4 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC36566.1 - 9.1e-05 22.6 40.2 0.0012 19.1 7.5 2.9 2 1 1 3 3 3 2 EamA-like transporter family DUF1003 PF06210.11 EFC36566.1 - 0.15 12.2 5.4 0.052 13.6 1.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1003) ATP19 PF11022.8 EFC36566.1 - 0.22 11.9 1.9 1.9 8.9 1.8 2.5 2 0 0 2 2 2 0 ATP synthase subunit K DUF4231 PF14015.6 EFC36566.1 - 0.57 10.7 9.6 1.4 9.5 0.0 3.5 2 1 0 3 3 3 0 Protein of unknown function (DUF4231) F-box PF00646.33 EFC36567.1 - 0.0022 17.8 0.1 0.0064 16.3 0.1 1.8 1 0 0 1 1 1 1 F-box domain DUF2659 PF10858.8 EFC36567.1 - 0.067 12.8 0.0 0.18 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2659) Zip PF02535.22 EFC36568.1 - 0.00095 18.5 0.9 0.001 18.4 0.9 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Nucleoporin_FG2 PF15967.5 EFC36569.1 - 1 7.8 28.9 1.4 7.3 28.9 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region BTB PF00651.31 EFC36570.1 - 1.5e-14 54.2 1.1 2.5e-14 53.4 0.3 1.7 2 0 0 2 2 2 1 BTB/POZ domain Fanconi_A_N PF15865.5 EFC36570.1 - 0.0045 16.4 0.7 0.0073 15.7 0.7 1.3 1 0 0 1 1 1 1 Fanconi anaemia group A protein N terminus Lep_receptor_Ig PF06328.11 EFC36570.1 - 0.39 10.7 3.0 80 3.3 0.0 3.8 4 0 0 4 4 4 0 Ig-like C2-type domain Cofilin_ADF PF00241.20 EFC36571.1 - 3.3e-33 114.0 0.4 3.6e-33 113.9 0.4 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein RhoGEF PF00621.20 EFC36572.1 - 0.0058 16.9 4.0 0.13 12.5 4.0 2.5 1 1 0 1 1 1 1 RhoGEF domain Ras PF00071.22 EFC36573.1 - 5.8e-46 156.0 0.0 8.4e-46 155.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36573.1 - 1.1e-26 93.4 0.1 2.6e-26 92.2 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC36573.1 - 6.8e-11 41.9 0.0 9.4e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC36573.1 - 4e-05 23.7 0.0 6.8e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC36573.1 - 9.8e-05 21.8 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EFC36573.1 - 0.0078 15.8 0.3 0.18 11.3 0.3 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC36573.1 - 0.008 16.1 0.1 0.45 10.4 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 EFC36573.1 - 0.0095 15.7 0.1 1.3 8.8 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFC36573.1 - 0.013 14.9 0.0 0.026 14.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFC36573.1 - 0.024 14.2 0.0 0.058 12.9 0.0 1.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NHL PF01436.21 EFC36574.1 - 2.6e-38 128.2 1.3 0.00027 20.8 0.2 10.8 10 0 0 10 10 10 8 NHL repeat SGL PF08450.12 EFC36574.1 - 2.4e-07 30.6 0.2 3.2 7.3 0.0 5.5 3 2 0 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC36574.1 - 6.9e-07 29.5 30.5 0.00015 22.0 11.8 2.6 2 0 0 2 2 2 2 EGF-like domain Phytase-like PF13449.6 EFC36574.1 - 0.00022 21.3 0.5 7.4 6.4 0.0 4.8 4 1 1 5 5 5 2 Esterase-like activity of phytase DUF1533 PF07550.11 EFC36574.1 - 0.3 11.0 3.0 8.4 6.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1533) YSIRK_signal PF04650.17 EFC36574.1 - 0.51 10.3 3.2 20 5.1 0.1 3.3 3 0 0 3 3 3 0 YSIRK type signal peptide SBBP PF06739.11 EFC36574.1 - 0.77 9.8 10.4 0.96 9.5 0.1 4.6 4 0 0 4 4 4 0 Beta-propeller repeat IU_nuc_hydro PF01156.19 EFC36575.1 - 1.3e-43 149.8 0.0 1.5e-43 149.5 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase LRR_6 PF13516.6 EFC36576.1 - 4e-15 54.5 13.2 0.00018 21.3 0.1 4.9 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 EFC36576.1 - 5e-14 52.2 31.4 1.4e-06 28.6 3.6 3.9 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36576.1 - 3.6e-12 45.9 11.3 8.9e-07 28.6 1.3 3.1 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EFC36576.1 - 7.3e-06 25.8 9.2 8 7.4 0.1 5.5 5 0 0 5 5 5 4 Leucine Rich Repeat ApoB100_C PF12491.8 EFC36576.1 - 0.076 13.0 4.1 3.9 7.5 0.0 3.7 3 1 0 3 3 3 0 Apolipoprotein B100 C terminal Beta_helix PF13229.6 EFC36576.1 - 0.66 9.8 7.5 0.061 13.2 3.0 1.7 2 1 0 2 2 2 0 Right handed beta helix region ATP-grasp_5 PF13549.6 EFC36577.1 - 3.9e-57 193.3 0.0 8.3e-57 192.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EFC36577.1 - 7.1e-36 123.0 0.9 1.7e-34 118.6 0.1 3.3 2 1 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain Acetyltransf_1 PF00583.25 EFC36577.1 - 1.1e-11 44.9 0.0 2.9e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 EFC36577.1 - 9.3e-09 36.1 0.0 2.4e-08 34.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ATP-grasp_2 PF08442.10 EFC36577.1 - 1.3e-06 28.1 0.6 1e-05 25.2 0.1 2.5 2 0 0 2 2 2 1 ATP-grasp domain Acetyltransf_4 PF13420.7 EFC36577.1 - 2.8e-06 27.5 0.1 0.00018 21.7 0.1 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC36577.1 - 5e-06 26.5 0.2 1.9e-05 24.6 0.2 2.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC36577.1 - 0.00095 19.6 0.1 0.0031 17.9 0.1 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFC36577.1 - 0.0048 16.6 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain RimK PF08443.11 EFC36577.1 - 0.011 15.4 1.8 0.024 14.2 0.0 2.5 3 0 0 3 3 3 0 RimK-like ATP-grasp domain CoA_binding PF02629.19 EFC36577.1 - 0.026 15.2 1.6 0.14 12.9 0.0 3.0 3 0 0 3 3 3 0 CoA binding domain GFO_IDH_MocA PF01408.22 EFC36577.1 - 0.067 14.0 0.1 94 3.9 0.0 3.9 4 0 0 4 4 4 0 Oxidoreductase family, NAD-binding Rossmann fold CPSase_L_D2 PF02786.17 EFC36577.1 - 0.076 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain NLRC4_HD PF17889.1 EFC36577.1 - 0.18 12.1 1.8 10 6.5 0.0 3.4 3 0 0 3 3 2 0 NLRC4 helical domain DUF4668 PF15701.5 EFC36578.1 - 4.7 7.0 10.6 7 6.4 0.2 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4668) DUF2530 PF10745.9 EFC36578.1 - 6.2 7.1 8.9 0.45 10.8 0.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) F-box-like PF12937.7 EFC36579.1 - 0.00014 21.6 0.1 0.00032 20.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like DUF4303 PF14136.6 EFC36579.1 - 0.77 9.5 6.9 3.7 7.3 0.1 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4303) PTPlike_phytase PF14566.6 EFC36580.1 - 7.5e-06 26.1 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 EFC36580.1 - 3.3e-05 23.7 0.0 4e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFC36580.1 - 0.00017 21.6 0.0 0.00026 21.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC36580.1 - 0.0035 16.9 0.0 0.0066 16.1 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC36580.1 - 0.022 14.4 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 EFC36580.1 - 0.086 12.4 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family MutS_V PF00488.21 EFC36581.1 - 2.8e-49 167.7 0.4 6.8e-49 166.5 0.4 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFC36581.1 - 1.7e-27 96.9 0.8 4.8e-27 95.4 0.3 2.0 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EFC36581.1 - 4e-05 23.9 0.1 0.00013 22.2 0.1 2.0 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EFC36581.1 - 0.022 15.0 0.0 0.12 12.7 0.0 2.2 2 0 0 2 2 2 0 MutS domain II AAA_21 PF13304.6 EFC36581.1 - 0.064 13.1 6.5 7.6 6.2 1.1 3.8 3 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AF0941-like PF14591.6 EFC36581.1 - 0.78 10.3 5.0 6.6 7.3 2.8 3.1 2 0 0 2 2 2 0 AF0941-like Ank_2 PF12796.7 EFC36582.1 - 9.5e-13 48.6 4.2 6.1e-07 29.9 0.4 1.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC36582.1 - 1.7e-07 31.3 0.0 3.9e-07 30.2 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC36582.1 - 7.8e-06 26.3 0.1 0.0014 19.2 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC36582.1 - 4.4e-05 23.5 0.2 0.003 17.9 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFC36582.1 - 0.00016 21.9 0.0 0.00051 20.4 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeat TPR_2 PF07719.17 EFC36583.1 - 0.00044 20.1 0.6 1.6 9.0 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 EFC36583.1 - 0.00048 19.6 4.1 0.0011 18.4 3.3 2.0 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_1 PF00515.28 EFC36583.1 - 0.0016 18.2 0.4 1 9.3 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF2225 PF09986.9 EFC36583.1 - 0.01 15.6 1.7 0.022 14.5 1.7 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_8 PF13181.6 EFC36583.1 - 0.012 15.8 1.5 39 4.8 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Vps55 PF04133.14 EFC36584.1 - 1.9e-31 108.4 7.7 2.3e-31 108.2 7.7 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting 55 MFS_2 PF13347.6 EFC36584.1 - 0.018 13.6 6.2 0.026 13.1 5.6 1.5 1 1 0 1 1 1 0 MFS/sugar transport protein RseC_MucC PF04246.12 EFC36584.1 - 9.3 6.2 6.3 5 7.1 1.2 2.2 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC F-box PF00646.33 EFC36585.1 - 5.1e-07 29.4 0.3 9.5e-07 28.5 0.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC36585.1 - 5.2e-05 23.0 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFC36585.1 - 0.00034 20.5 0.1 0.00047 20.0 0.1 1.3 1 0 0 1 1 1 1 F-box ShlB PF03865.13 EFC36585.1 - 0.041 13.3 0.0 0.059 12.8 0.0 1.2 1 0 0 1 1 1 0 Haemolysin secretion/activation protein ShlB/FhaC/HecB F-box_5 PF18511.1 EFC36585.1 - 0.065 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 F-box RasGEF PF00617.19 EFC36586.1 - 4.3e-27 95.5 5.4 3.6e-26 92.4 2.7 2.4 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFC36586.1 - 0.00021 21.5 1.5 0.00085 19.5 1.5 2.1 1 0 0 1 1 1 1 RasGEF N-terminal motif Pkinase_Tyr PF07714.17 EFC36588.1 - 8.4e-49 166.2 0.5 4.8e-48 163.7 0.5 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC36588.1 - 2.2e-46 158.3 0.6 5e-46 157.2 0.6 1.6 1 0 0 1 1 1 1 Protein kinase domain ECSCR PF15820.5 EFC36588.1 - 0.0081 16.0 0.5 0.04 13.7 0.5 2.2 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator Pkinase_fungal PF17667.1 EFC36588.1 - 0.042 12.6 0.0 0.069 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase LapA_dom PF06305.11 EFC36588.1 - 0.046 13.5 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Vpu PF00558.19 EFC36588.1 - 0.078 12.8 0.3 0.19 11.5 0.3 1.6 1 0 0 1 1 1 0 Vpu protein DUF5385 PF17359.2 EFC36588.1 - 0.13 11.8 2.0 0.25 10.9 2.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) GRIM-19 PF06212.12 EFC36588.1 - 0.14 12.1 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 GRIM-19 protein CTP_transf_1 PF01148.20 EFC36588.1 - 1.1 8.9 3.7 0.4 10.4 0.1 2.2 3 0 0 3 3 3 0 Cytidylyltransferase family Chlam_PMP PF02415.17 EFC36588.1 - 1.9 9.1 15.4 0.44 11.1 1.2 5.0 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat TMEMspv1-c74-12 PF11044.8 EFC36588.1 - 8 6.5 8.8 0.92 9.5 3.6 2.1 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein IF4E PF01652.18 EFC36589.1 - 2.1e-40 138.1 0.4 2.6e-40 137.8 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E IF4E PF01652.18 EFC36590.1 - 2.6e-43 147.6 0.8 3.4e-43 147.2 0.8 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E HSP90 PF00183.18 EFC36590.1 - 0.14 11.0 2.6 0.22 10.4 2.6 1.3 1 0 0 1 1 1 0 Hsp90 protein GATase PF00117.28 EFC36591.1 - 4.6e-11 42.9 0.0 7.1e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFC36591.1 - 6.1e-06 26.1 0.0 0.0049 16.7 0.0 3.2 3 0 0 3 3 3 1 Peptidase C26 GATase_3 PF07685.14 EFC36591.1 - 1.9e-05 24.4 0.0 2.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GramPos_pilinBB PF16569.5 EFC36591.1 - 0.00037 21.3 0.9 0.014 16.3 0.2 2.3 2 0 0 2 2 2 1 Gram-positive pilin backbone subunit 2, Cna-B-like domain DJ-1_PfpI PF01965.24 EFC36591.1 - 0.00088 19.1 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 EFC36591.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 ThiJ/PfpI family-like SNO PF01174.19 EFC36591.1 - 0.03 14.2 0.0 0.12 12.3 0.0 2.1 1 1 0 1 1 1 0 SNO glutamine amidotransferase family F-box PF00646.33 EFC36592.1 - 0.035 14.0 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 F-box domain HATPase_c PF02518.26 EFC36593.1 - 4.8e-22 78.6 0.0 1e-21 77.6 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC36593.1 - 4.7e-14 52.2 0.1 1.1e-13 51.0 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EFC36593.1 - 1.4e-05 24.9 0.0 7.3e-05 22.6 0.0 2.3 1 0 0 1 1 1 1 GHKL domain Response_reg PF00072.24 EFC36593.1 - 2.4e-05 24.4 0.0 5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain Mod_r PF07200.13 EFC36596.1 - 2.1e-25 89.5 13.6 2.1e-25 89.5 13.6 1.4 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein UQ_con PF00179.26 EFC36596.1 - 1.3e-06 28.1 0.1 3.1e-06 26.9 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 EFC36596.1 - 0.00013 21.8 0.1 0.00033 20.5 0.1 1.7 1 0 0 1 1 1 1 UEV domain DUF641 PF04859.12 EFC36596.1 - 0.081 13.3 5.2 0.15 12.4 5.2 1.4 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) KLRAQ PF10205.9 EFC36596.1 - 0.47 10.7 11.6 0.13 12.5 8.2 1.8 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Staphylokinase PF02821.16 EFC36596.1 - 0.73 10.3 6.7 2.3 8.7 0.1 2.4 1 1 1 2 2 2 0 Staphylokinase/Streptokinase family TOPRIM_C PF16898.5 EFC36596.1 - 1.7 9.0 5.7 13 6.1 1.3 2.9 4 0 0 4 4 4 0 C-terminal associated domain of TOPRIM Fes1 PF08609.10 EFC36596.1 - 3.6 8.5 7.2 1.8 9.5 4.4 2.0 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 RGS PF00615.19 EFC36597.1 - 2.8e-05 24.4 6.3 9.2e-05 22.7 6.3 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF5601 PF18151.1 EFC36597.1 - 0.098 13.0 2.3 0.34 11.2 2.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5601) RRM_1 PF00076.22 EFC36598.1 - 4e-13 49.0 0.0 1.3e-12 47.3 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_17 PF13431.6 EFC36598.1 - 0.12 12.8 2.6 6.6 7.4 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC36598.1 - 0.17 12.1 2.9 16 5.8 0.1 3.1 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Phage_TAC_10 PF10963.8 EFC36598.1 - 0.19 11.9 4.7 2.4 8.4 0.3 2.8 2 0 0 2 2 2 0 Phage tail assembly chaperone LRR_6 PF13516.6 EFC36599.1 - 6.2e-53 172.4 4.5 0.0002 21.1 0.0 12.3 12 0 0 12 12 12 12 Leucine Rich repeat LRR_8 PF13855.6 EFC36599.1 - 2e-26 91.5 14.4 5.4e-06 26.1 0.1 6.2 3 2 4 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC36599.1 - 4.1e-26 90.6 13.1 0.0061 17.0 0.0 8.0 1 1 10 12 12 12 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36599.1 - 3.1e-13 48.3 4.4 6.5 7.7 0.1 11.2 12 0 0 12 12 12 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC36599.1 - 2e-07 30.6 5.7 0.027 14.0 0.2 4.2 1 1 3 4 4 4 4 Leucine-rich repeat Apo-VLDL-II PF05418.11 EFC36599.1 - 5e-05 23.8 0.2 13 6.4 0.0 6.0 3 1 3 7 7 7 1 Apovitellenin I (Apo-VLDL-II) DUF2513 PF10711.9 EFC36599.1 - 0.018 15.3 1.3 2.7 8.3 0.1 3.6 2 1 1 3 3 3 0 Hypothetical protein (DUF2513) YjcQ PF09639.10 EFC36599.1 - 0.041 14.1 16.0 1.2 9.4 1.5 6.0 1 1 6 7 7 7 0 YjcQ protein Mgm101p PF06420.12 EFC36599.1 - 2.1 7.9 4.4 29 4.1 0.1 3.7 2 1 1 4 4 4 0 Mitochondrial genome maintenance MGM101 GNT-I PF03071.15 EFC36603.1 - 3.3e-06 26.1 1.6 5.4e-06 25.4 1.6 1.2 1 0 0 1 1 1 1 GNT-I family MGAT2 PF05060.14 EFC36603.1 - 5.1e-06 25.8 0.3 1.2e-05 24.5 0.2 1.7 2 0 0 2 2 2 1 N-acetylglucosaminyltransferase II (MGAT2) EF-hand_9 PF14658.6 EFC36604.1 - 0.00044 20.5 0.3 0.0087 16.4 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_6 PF13405.6 EFC36604.1 - 0.0018 18.0 1.4 0.038 13.9 0.3 3.1 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 EFC36604.1 - 0.003 18.0 2.1 0.08 13.4 0.6 2.7 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EFC36604.1 - 0.023 14.5 0.6 0.65 9.9 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EFC36604.1 - 0.075 12.6 1.8 3.9 7.3 0.4 3.3 3 0 0 3 3 3 0 EF hand Slx4 PF09494.10 EFC36605.1 - 0.13 12.2 0.0 0.42 10.6 0.0 1.8 2 0 0 2 2 2 0 Slx4 endonuclease SRTM1 PF15872.5 EFC36605.1 - 1.1 9.5 11.0 0.14 12.3 6.3 2.1 2 1 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 EF-hand_9 PF14658.6 EFC36607.1 - 1e-05 25.8 0.4 0.0026 18.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EFC36607.1 - 0.003 18.0 3.1 0.0089 16.5 2.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair zf_CCCH_4 PF18345.1 EFC36608.1 - 8.3e-12 44.7 20.0 2.2e-06 27.5 6.5 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 EFC36608.1 - 7.9e-09 35.2 18.3 4e-05 23.4 6.6 2.5 1 1 1 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 EFC36608.1 - 8.2e-06 26.0 13.7 0.011 15.9 4.2 3.0 1 1 1 2 2 2 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 EFC36608.1 - 4.4e-05 23.2 21.0 0.0076 16.0 7.6 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EFC36608.1 - 0.0011 19.7 19.3 0.0022 18.7 4.7 3.0 2 1 1 3 3 3 2 Torus domain zf-CCCH_2 PF14608.6 EFC36608.1 - 1.7 9.2 30.2 0.062 13.8 8.4 3.3 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger SRP-alpha_N PF04086.13 EFC36608.1 - 2 8.3 22.0 5.5 6.8 19.1 2.2 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 EFC36608.1 - 5.4 5.7 10.6 7.8 5.2 10.6 1.2 1 0 0 1 1 1 0 Presenilin FAD-oxidase_C PF02913.19 EFC36609.1 - 2.3e-46 158.5 0.0 3.2e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFC36609.1 - 1.5e-30 105.7 0.4 2.8e-30 104.9 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain SHOCT PF09851.9 EFC36610.1 - 1.3e-09 37.5 0.6 1.3e-09 37.5 0.6 2.2 2 0 0 2 2 2 1 Short C-terminal domain Abhydrolase_1 PF00561.20 EFC36611.1 - 0.00038 20.2 0.0 0.034 13.8 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC36611.1 - 0.001 18.4 0.0 0.11 11.8 0.0 3.0 2 1 0 2 2 2 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 EFC36611.1 - 0.051 12.7 0.1 0.47 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Tubulin_2 PF13809.6 EFC36611.1 - 0.19 10.9 0.7 0.53 9.4 0.4 1.8 1 1 1 2 2 2 0 Tubulin like FMN_red PF03358.15 EFC36612.1 - 3.8e-12 46.2 0.1 1.5e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 EFC36612.1 - 0.00018 21.3 0.0 0.00037 20.2 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 EFC36612.1 - 0.0013 19.0 0.0 0.0083 16.4 0.0 2.2 1 1 1 2 2 2 1 Flavodoxin domain Flavodoxin_1 PF00258.25 EFC36612.1 - 0.003 17.8 0.0 3.5 7.8 0.0 2.5 1 1 1 2 2 2 2 Flavodoxin PTS_IIB PF02302.17 EFC36612.1 - 0.047 14.4 0.5 1.4 9.6 0.0 2.5 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit PAP1 PF08601.10 EFC36612.1 - 0.09 12.5 8.5 0.12 12.1 8.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 TCP PF03634.13 EFC36612.1 - 1.5 9.4 9.0 2.2 8.8 9.0 1.2 1 0 0 1 1 1 0 TCP family transcription factor AhpC-TSA PF00578.21 EFC36613.1 - 1.4e-33 115.4 0.4 1.8e-33 115.1 0.4 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC36613.1 - 1e-21 77.2 0.4 1.5e-21 76.7 0.4 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 EFC36613.1 - 0.00064 19.8 0.0 0.00088 19.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Thioredoxin_8 PF13905.6 EFC36613.1 - 0.0088 16.4 0.2 0.016 15.5 0.2 1.5 1 0 0 1 1 1 1 Thioredoxin-like adh_short PF00106.25 EFC36615.1 - 1.1e-49 168.6 0.6 1.4e-49 168.3 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36615.1 - 8.7e-48 162.9 0.6 1.1e-47 162.6 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC36615.1 - 8.8e-10 38.8 1.1 1e-09 38.6 0.3 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EFC36615.1 - 8.6e-05 22.1 0.3 0.00028 20.4 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family AdoHcyase_NAD PF00670.21 EFC36615.1 - 0.00066 19.8 0.9 0.0013 18.8 0.9 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 EFC36615.1 - 0.00066 19.6 1.8 0.00093 19.1 0.7 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DnaJ_C PF01556.18 EFC36616.1 - 1.3e-37 129.2 1.1 1.9e-37 128.6 1.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFC36616.1 - 3.3e-21 75.2 9.0 6.5e-21 74.2 6.8 2.4 3 0 0 3 3 3 1 DnaJ domain TssO PF17561.2 EFC36616.1 - 8.5 6.5 7.3 22 5.1 1.3 2.6 1 1 1 2 2 2 0 Type VI secretion system, TssO RCC1_2 PF13540.6 EFC36617.1 - 0.034 14.0 0.0 0.095 12.5 0.0 1.7 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat Tox-SGS PF15651.6 EFC36618.1 - 0.15 12.3 0.7 1.6 9.0 0.1 2.3 2 0 0 2 2 2 0 Salivary glad secreted protein domain toxin Orf78 PF06024.12 EFC36618.1 - 0.19 12.1 0.2 0.43 10.9 0.2 1.6 1 0 0 1 1 1 0 Orf78 (ac78) UQ_con PF00179.26 EFC36619.1 - 9.1e-25 86.9 0.1 2e-24 85.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme LRR_6 PF13516.6 EFC36619.1 - 2.9e-10 39.4 0.2 0.00084 19.2 0.0 2.9 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.7 EFC36619.1 - 2.8e-06 27.5 4.9 3.2e-06 27.4 1.1 3.2 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36619.1 - 0.00092 18.9 1.3 0.033 13.9 1.3 3.1 1 1 0 1 1 1 1 Leucine rich repeat LRR_1 PF00560.33 EFC36619.1 - 0.0023 18.2 0.5 4.3 8.3 0.0 4.7 2 0 0 2 2 2 1 Leucine Rich Repeat RWD PF05773.22 EFC36619.1 - 0.0026 18.0 0.3 0.1 12.9 0.0 2.9 2 1 0 2 2 2 1 RWD domain LRR_2 PF07723.13 EFC36619.1 - 0.0092 16.6 2.9 1.2 9.9 0.3 5.2 5 0 0 5 5 5 1 Leucine Rich Repeat APAF1_C PF17908.1 EFC36619.1 - 0.28 11.2 3.6 0.42 10.6 1.9 2.3 2 0 0 2 2 2 0 APAF-1 helical domain EGF_2 PF07974.13 EFC36621.1 - 1.6e-12 47.5 41.4 8e-05 22.9 9.4 3.7 3 0 0 3 3 3 3 EGF-like domain RGS PF00615.19 EFC36621.1 - 5.5e-11 42.8 5.6 5.5e-11 42.8 5.6 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain GPS PF01825.21 EFC36621.1 - 9.9e-08 32.4 6.1 2.9e-07 30.9 6.1 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF PF00008.27 EFC36621.1 - 0.92 9.9 40.0 0.16 12.3 4.4 3.9 4 0 0 4 4 4 0 EGF-like domain DGC PF08859.11 EFC36622.1 - 0.055 13.6 1.0 0.1 12.7 1.0 1.4 1 0 0 1 1 1 0 DGC domain Ras PF00071.22 EFC36622.1 - 0.077 12.6 0.0 0.6 9.7 0.0 2.2 1 1 0 1 1 1 0 Ras family MMR_HSR1 PF01926.23 EFC36622.1 - 0.092 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase tRNA-synt_1b PF00579.25 EFC36623.1 - 4.9e-73 246.0 0.1 7.9e-73 245.3 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 EFC36623.1 - 0.00036 20.2 0.0 0.00073 19.2 0.0 1.5 1 0 0 1 1 1 1 S4 domain Gal4_dimer PF03902.13 EFC36623.1 - 0.19 11.9 0.9 0.54 10.5 0.9 1.7 1 0 0 1 1 1 0 Gal4-like dimerisation domain DUF1963 PF09234.10 EFC36624.1 - 1e-07 32.7 1.6 3.4e-06 27.7 0.2 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF1963) F-box-like PF12937.7 EFC36624.1 - 0.00027 20.8 0.1 0.0006 19.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC36624.1 - 0.069 13.1 0.2 0.16 11.9 0.2 1.7 1 0 0 1 1 1 0 F-box domain ubiquitin PF00240.23 EFC36625.1 - 1.2e-32 111.5 0.9 1.3e-32 111.4 0.9 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC36625.1 - 8.1e-16 57.6 0.9 8.9e-16 57.5 0.9 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFC36625.1 - 1.3e-05 25.3 0.1 3.4e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC36625.1 - 2.9e-05 24.4 0.4 9.4e-05 22.8 0.4 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 EFC36625.1 - 0.00028 21.4 0.1 0.00031 21.3 0.1 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 EFC36625.1 - 0.00032 20.6 0.1 0.00034 20.5 0.1 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC36625.1 - 0.0018 18.6 0.1 0.0021 18.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC36625.1 - 0.004 17.2 0.4 0.38 10.8 0.1 2.0 1 1 1 2 2 2 2 Ubiquitin-like domain PI3K_rbd PF00794.18 EFC36625.1 - 0.087 13.0 0.3 0.18 12.0 0.2 1.7 1 1 1 2 2 2 0 PI3-kinase family, ras-binding domain RRM_1 PF00076.22 EFC36626.1 - 3.5e-16 58.8 0.1 8.2e-16 57.6 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 EFC36627.1 - 3.7e-17 62.4 8.6 0.0011 19.7 0.2 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36627.1 - 2.5e-12 46.9 1.1 0.00096 19.4 0.0 4.2 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 EFC36627.1 - 0.0033 16.3 1.3 0.38 9.5 0.0 3.1 1 1 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ge1_WD40 PF16529.5 EFC36627.1 - 0.0076 15.3 1.5 0.95 8.4 0.4 3.5 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 EFC36627.1 - 0.011 15.6 7.1 0.083 12.8 0.8 3.7 2 1 1 4 4 4 0 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EFC36628.1 - 2.5e-07 31.3 5.3 0.016 16.1 0.3 5.2 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36628.1 - 1.2e-05 25.5 0.0 0.45 10.8 0.0 3.6 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFC36628.1 - 0.008 14.7 0.0 0.011 14.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome D1 heme domain Lactonase PF10282.9 EFC36628.1 - 0.069 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller PP2C PF00481.21 EFC36629.1 - 2.3e-45 155.3 0.1 2.7e-45 155.0 0.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PPP1R35_C PF15503.6 EFC36629.1 - 0.11 12.4 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus Ndc1_Nup PF09531.10 EFC36630.1 - 0.51 9.0 13.2 0.59 8.8 13.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Miga PF10265.9 EFC36630.1 - 2.5 7.0 12.4 3.1 6.7 12.4 1.2 1 0 0 1 1 1 0 Mitoguardin SPX PF03105.19 EFC36630.1 - 4.9 7.0 20.5 6.4 6.6 20.5 1.3 1 0 0 1 1 1 0 SPX domain GREB1 PF15782.5 EFC36630.1 - 7.1 3.6 15.8 8.5 3.3 15.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 EFC36630.1 - 8 4.9 20.1 11 4.4 20.1 1.3 1 0 0 1 1 1 0 Macoilin family GpcrRhopsn4 PF10192.9 EFC36631.1 - 1.8e-51 175.0 24.9 3.4e-51 174.1 24.9 1.4 1 0 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Glyco_hydro_101 PF12905.7 EFC36631.1 - 0.14 11.6 0.3 0.21 11.0 0.3 1.2 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase UBA PF00627.31 EFC36632.1 - 0.018 15.0 0.0 0.073 13.0 0.0 2.2 1 0 0 1 1 1 0 UBA/TS-N domain RRM_1 PF00076.22 EFC36633.1 - 6.5e-07 29.1 0.1 1.4e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) His_Phos_1 PF00300.22 EFC36634.1 - 2.6e-12 46.8 0.0 6e-05 22.8 0.1 2.8 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) PQ-loop PF04193.14 EFC36635.1 - 3.6e-30 103.5 13.2 4.9e-19 67.9 7.0 2.5 2 0 0 2 2 2 2 PQ loop repeat ODV-E18 PF10717.9 EFC36635.1 - 0.077 12.9 0.9 0.17 11.7 0.9 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 EI24 PF07264.11 EFC36635.1 - 0.31 11.3 9.2 12 6.1 6.8 2.7 2 1 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) vMSA PF00695.19 EFC36635.1 - 0.78 8.8 5.6 0.86 8.6 0.7 2.0 2 0 0 2 2 2 0 Major surface antigen from hepadnavirus PhyH PF05721.13 EFC36636.1 - 1.1e-42 146.6 0.1 2.3e-42 145.7 0.1 1.5 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PrkA PF06798.12 EFC36636.1 - 0.013 15.1 0.2 0.013 15.1 0.2 1.6 2 0 0 2 2 2 0 PrkA serine protein kinase C-terminal domain P35 PF02331.15 EFC36636.1 - 0.018 14.4 3.8 0.12 11.8 0.1 2.2 2 0 0 2 2 2 0 Apoptosis preventing protein 2OG-FeII_Oxy_5 PF13759.6 EFC36636.1 - 0.022 15.2 0.0 0.063 13.7 0.0 1.8 1 1 1 2 2 2 0 Putative 2OG-Fe(II) oxygenase COG5 PF10392.9 EFC36637.1 - 0.035 14.3 0.3 0.035 14.3 0.3 4.1 5 1 0 5 5 5 0 Golgi transport complex subunit 5 SPOB_ab PF14682.6 EFC36637.1 - 0.074 13.1 3.4 0.67 10.0 0.1 3.4 2 1 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal ArsR PF09824.9 EFC36638.1 - 0.019 14.6 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 ArsR transcriptional regulator Zn_clus PF00172.18 EFC36639.1 - 6.5e-08 32.6 15.0 1.5e-07 31.4 15.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNMT1-RFD PF12047.8 EFC36639.1 - 0.039 14.0 0.1 0.1 12.6 0.1 1.8 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain LRR_6 PF13516.6 EFC36640.1 - 2.2e-08 33.5 0.1 0.00031 20.6 0.0 3.1 2 0 0 2 2 2 2 Leucine Rich repeat F-box-like PF12937.7 EFC36640.1 - 0.003 17.4 0.2 0.0057 16.5 0.2 1.5 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFC36640.1 - 0.013 15.9 1.4 0.051 14.0 0.2 2.4 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) Zn_clus PF00172.18 EFC36641.1 - 5.1e-08 32.9 14.2 1.1e-07 31.8 14.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Muted PF14942.6 EFC36641.1 - 1.7 9.0 8.1 3.8 7.9 2.4 2.6 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Zn_clus PF00172.18 EFC36642.1 - 2.1e-07 30.9 14.9 5.3e-07 29.7 14.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FDC-SP PF15215.6 EFC36642.1 - 0.0065 17.0 0.0 0.039 14.5 0.0 2.2 2 0 0 2 2 2 1 Follicular dendritic cell secreted peptide Orf78 PF06024.12 EFC36643.1 - 0.011 16.0 0.3 1.1 9.6 0.0 2.2 2 0 0 2 2 2 0 Orf78 (ac78) adh_short PF00106.25 EFC36644.1 - 2.1e-25 89.3 0.0 7.6e-25 87.5 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36644.1 - 7.7e-17 61.6 0.0 3e-16 59.7 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC36644.1 - 0.0019 18.1 0.1 0.0034 17.3 0.1 1.3 1 0 0 1 1 1 1 KR domain MIP PF00230.20 EFC36645.1 - 5.3e-48 163.7 15.4 6.5e-48 163.4 15.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF872 PF05915.12 EFC36645.1 - 0.051 13.7 1.3 0.9 9.7 0.1 2.6 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) zf-CHC2 PF01807.20 EFC36646.1 - 0.078 12.8 0.0 0.22 11.3 0.0 1.7 1 1 0 1 1 1 0 CHC2 zinc finger Trypsin_2 PF13365.6 EFC36647.1 - 7.1e-17 62.7 0.0 1.4e-16 61.7 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFC36647.1 - 3.7e-08 33.5 0.4 2.9e-07 30.5 0.4 2.2 1 1 0 1 1 1 1 Trypsin Peptidase_S32 PF05579.13 EFC36647.1 - 5.8e-05 22.4 0.0 9.8e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Equine arteritis virus serine endopeptidase S32 DUF31 PF01732.16 EFC36647.1 - 0.00087 18.9 0.4 0.21 11.1 0.0 2.2 1 1 1 2 2 2 2 Putative peptidase (DUF31) Peptidase_S46 PF10459.9 EFC36647.1 - 0.0013 17.4 1.0 0.019 13.6 0.0 2.5 3 0 0 3 3 3 1 Peptidase S46 Peptidase_S7 PF00949.21 EFC36647.1 - 0.0017 18.2 0.2 0.0039 17.0 0.0 1.7 2 0 0 2 2 2 1 Peptidase S7, Flavivirus NS3 serine protease Peptidase_C3 PF00548.20 EFC36647.1 - 0.012 15.5 1.7 0.023 14.6 0.6 1.9 2 0 0 2 2 2 0 3C cysteine protease (picornain 3C) CBS PF00571.28 EFC36647.1 - 0.18 12.3 0.0 0.54 10.8 0.0 1.8 1 0 0 1 1 1 0 CBS domain ThiF PF00899.21 EFC36649.1 - 2e-40 138.7 0.0 2.7e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 ThiF family F420_oxidored PF03807.17 EFC36649.1 - 0.14 12.7 0.0 0.3 11.7 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF2368 PF10166.9 EFC36650.1 - 2.6e-19 69.2 0.3 2.9e-19 69.0 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) DUF4199 PF13858.6 EFC36650.1 - 0.042 14.3 0.7 0.07 13.5 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) YjfB_motility PF14070.6 EFC36650.1 - 2.9 8.1 7.9 4.5 7.5 7.9 1.2 1 0 0 1 1 1 0 Putative motility protein Hydrolase_4 PF12146.8 EFC36651.1 - 9e-12 44.8 0.0 9.8e-11 41.4 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC36651.1 - 1.3e-09 38.0 0.0 1.7e-06 27.9 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EFC36651.1 - 5e-07 29.7 0.0 7.4e-05 22.7 0.0 3.1 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase DUF818 PF05677.12 EFC36651.1 - 1.6e-05 24.0 0.3 3e-05 23.1 0.1 1.5 2 0 0 2 2 2 1 Chlamydia CHLPS protein (DUF818) BAAT_C PF08840.11 EFC36651.1 - 7.4e-05 22.8 0.0 0.00028 20.9 0.0 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 EFC36651.1 - 0.00013 21.9 0.0 0.00022 21.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC36651.1 - 0.00032 20.3 0.0 0.0024 17.4 0.0 2.1 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFC36651.1 - 0.00035 21.3 0.0 0.00046 20.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EFC36651.1 - 0.0076 15.8 0.0 1.5 8.3 0.0 2.5 3 0 0 3 3 3 1 Dienelactone hydrolase family FSH1 PF03959.13 EFC36651.1 - 0.011 15.4 0.0 0.029 14.0 0.0 1.8 1 1 0 1 1 1 0 Serine hydrolase (FSH1) UPF0227 PF05728.12 EFC36651.1 - 0.013 15.5 0.0 0.037 14.0 0.0 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) Lipase_3 PF01764.25 EFC36651.1 - 0.029 14.2 0.0 0.079 12.8 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) Esterase PF00756.20 EFC36651.1 - 0.037 13.7 0.0 0.077 12.6 0.0 1.5 1 1 0 1 1 1 0 Putative esterase Thioesterase PF00975.20 EFC36651.1 - 0.075 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Aa_trans PF01490.18 EFC36652.1 - 8.6e-42 143.3 20.5 8.6e-42 143.3 20.5 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1676 PF07898.13 EFC36652.1 - 1.2 9.1 4.2 12 5.9 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1676) HMG_box PF00505.19 EFC36653.1 - 0.11 12.9 0.1 0.26 11.7 0.1 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box Pkinase PF00069.25 EFC36654.1 - 1.4e-41 142.6 0.1 2e-41 142.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36654.1 - 3.6e-21 75.6 0.0 5.4e-21 75.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC36654.1 - 1.3e-05 24.7 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EFC36654.1 - 0.00056 19.6 0.8 0.058 13.0 0.0 2.6 3 0 0 3 3 3 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EFC36654.1 - 0.0041 16.0 0.0 0.0062 15.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Ret2_MD PF18528.1 EFC36654.1 - 0.0094 16.3 0.0 0.022 15.2 0.0 1.6 1 0 0 1 1 1 1 RNA editing 3' terminal uridylyl transferase 2 middle domain APH PF01636.23 EFC36654.1 - 0.25 11.2 0.1 0.36 10.7 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFC36655.1 - 2.4e-39 135.3 0.0 3.8e-39 134.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36655.1 - 2.6e-21 76.1 0.0 4e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC36655.1 - 0.002 17.1 0.1 0.0035 16.4 0.0 1.4 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC36655.1 - 0.0029 16.5 0.0 0.004 16.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Rpn3_C PF08375.11 EFC36655.1 - 0.0055 17.1 0.1 0.016 15.6 0.1 1.8 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal Kdo PF06293.14 EFC36655.1 - 0.035 13.5 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4116 PF13475.6 EFC36656.1 - 2.7e-43 145.5 26.2 1.4e-13 50.4 0.1 10.4 4 3 6 12 12 12 12 Domain of unknown function (DUF4116) Glutaredoxin PF00462.24 EFC36657.1 - 0.096 12.9 0.3 0.26 11.5 0.3 1.7 1 0 0 1 1 1 0 Glutaredoxin DUF2063 PF09836.9 EFC36657.1 - 0.15 12.3 0.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Putative DNA-binding domain Acetyltransf_10 PF13673.7 EFC36659.1 - 0.0012 18.8 0.2 0.0028 17.6 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC36659.1 - 0.033 14.2 0.0 0.084 12.9 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_1 PF00583.25 EFC36659.1 - 0.048 13.9 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family RGS PF00615.19 EFC36662.1 - 1.3e-14 54.5 6.0 2.4e-14 53.6 4.8 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain HAMP PF00672.25 EFC36662.1 - 0.0002 21.6 0.0 0.00039 20.7 0.0 1.5 1 0 0 1 1 1 1 HAMP domain Zn_peptidase_2 PF04298.12 EFC36662.1 - 0.037 13.4 1.5 0.17 11.2 0.0 2.3 2 0 0 2 2 2 0 Putative neutral zinc metallopeptidase Claudin_2 PF13903.6 EFC36662.1 - 0.099 12.4 1.9 3.8 7.2 0.1 2.5 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF4706 PF15797.5 EFC36662.1 - 0.19 12.2 2.6 0.58 10.7 2.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) Shisa PF13908.6 EFC36662.1 - 0.34 11.1 1.2 1.3 9.2 0.2 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF805 PF05656.14 EFC36662.1 - 0.58 10.6 6.5 0.081 13.3 0.8 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF805) DUF948 PF06103.11 EFC36662.1 - 3.4 8.0 9.1 0.53 10.6 0.7 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Herpes_UL73 PF03554.13 EFC36662.1 - 7.3 6.7 9.6 2 8.5 3.3 2.6 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein Epimerase PF01370.21 EFC36663.1 - 1.3e-15 57.5 0.0 2.3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC36663.1 - 1.2e-14 54.1 0.0 2e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC36663.1 - 1.4e-12 47.3 0.0 1.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFC36663.1 - 5.1e-08 32.7 0.8 2.3e-07 30.6 0.1 2.3 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFC36663.1 - 5.5e-06 26.4 0.1 0.0058 16.5 0.0 2.3 2 0 0 2 2 2 2 NAD(P)H-binding NmrA PF05368.13 EFC36663.1 - 0.00056 19.5 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EFC36663.1 - 0.043 13.3 0.1 0.7 9.3 0.1 2.3 1 1 1 2 2 2 0 short chain dehydrogenase T4BSS_DotI_IcmL PF11393.8 EFC36663.1 - 0.052 13.0 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Type-IV b secretion system, inner-membrane complex component UvrD-helicase PF00580.21 EFC36664.1 - 2e-27 96.6 3.2 2e-27 96.5 0.1 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EFC36664.1 - 1.5e-16 61.1 0.0 2.8e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain zf-GRF PF06839.12 EFC36664.1 - 1.1e-09 38.2 2.4 2.3e-09 37.2 2.4 1.6 1 0 0 1 1 1 1 GRF zinc finger AAA_30 PF13604.6 EFC36664.1 - 0.00022 21.0 0.0 0.00031 20.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFC36664.1 - 0.0034 17.2 5.0 0.0058 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain DUF3440 PF11922.8 EFC36664.1 - 0.0081 15.9 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3440) Macoilin PF09726.9 EFC36664.1 - 9.9 4.6 14.5 13 4.2 14.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF4419 PF14388.6 EFC36665.1 - 9.6e-105 350.3 1.5 1.1e-104 350.1 1.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) NHL PF01436.21 EFC36666.1 - 5.2e-06 26.2 0.6 5.9 7.1 0.0 5.6 5 0 0 5 5 5 3 NHL repeat GPS PF01825.21 EFC36666.1 - 9.1e-05 22.9 0.3 0.00024 21.5 0.3 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC36666.1 - 0.0018 18.6 9.5 0.0018 18.6 9.5 2.2 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EFC36666.1 - 1.3 9.4 9.4 0.24 11.8 3.7 2.8 3 0 0 3 3 3 0 EGF-like domain EGF_Tenascin PF18720.1 EFC36666.1 - 5 7.3 12.9 17 5.6 12.9 1.9 1 0 0 1 1 1 0 Tenascin EGF domain RWP-RK PF02042.15 EFC36667.1 - 5.5e-09 35.9 0.2 1.4e-08 34.6 0.1 1.7 2 0 0 2 2 2 1 RWP-RK domain HTH_Tnp_ISL3 PF13542.6 EFC36667.1 - 0.037 13.4 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 EFC36667.1 - 0.046 13.5 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_24 PF13412.6 EFC36667.1 - 0.099 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Peptidase_C1 PF00112.23 EFC36668.1 - 8.6e-57 192.7 3.9 1.6e-56 191.8 3.9 1.5 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFC36668.1 - 2.2e-41 140.9 0.9 5.4e-41 139.6 0.9 1.7 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EFC36668.1 - 0.011 14.5 0.3 0.011 14.5 0.3 1.7 2 0 0 2 2 2 0 Peptidase C1-like family NIT PF08376.10 EFC36669.1 - 5.2e-33 115.4 0.0 8.5e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 Nitrate and nitrite sensing Guanylate_cyc PF00211.20 EFC36669.1 - 2.9e-24 85.7 0.0 9.8e-24 84.0 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Polysacc_synt_3 PF13440.6 EFC36669.1 - 0.33 10.1 10.0 0.3 10.2 0.6 2.7 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein SlyX PF04102.12 EFC36670.1 - 0.022 15.4 24.5 0.23 12.1 0.1 6.9 6 1 0 6 6 6 0 SlyX Serine_rich PF08824.10 EFC36670.1 - 0.023 14.7 4.1 1.1 9.2 1.0 3.3 2 0 0 2 2 2 0 Serine rich protein interaction domain NAD_binding_2 PF03446.15 EFC36670.1 - 0.024 14.8 0.1 0.088 13.0 0.1 2.0 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase tRNA-synt_His PF13393.6 EFC36670.1 - 0.088 12.1 6.1 2.2 7.5 0.8 3.5 3 0 0 3 3 3 0 Histidyl-tRNA synthetase DUF4796 PF16044.5 EFC36671.1 - 0.0074 15.9 0.3 0.02 14.5 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) CENP-B_dimeris PF09026.10 EFC36671.1 - 0.053 13.9 4.8 16 6.0 8.5 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain adh_short PF00106.25 EFC36672.1 - 1.7e-34 119.0 0.0 2.6e-34 118.4 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36672.1 - 2.9e-23 82.6 0.0 4e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC36672.1 - 8.4e-08 32.3 0.0 1.2e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF3906 PF13046.6 EFC36672.1 - 0.016 15.3 0.1 0.037 14.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) KRE1 PF17056.5 EFC36672.1 - 0.11 12.2 0.2 0.34 10.6 0.1 1.8 2 0 0 2 2 2 0 Killer toxin-resistance protein 1 LCAT PF02450.15 EFC36673.1 - 5.3e-37 127.9 0.3 4.2e-29 101.9 0.0 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EFC36673.1 - 0.00058 19.4 0.0 0.0016 18.0 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EFC36673.1 - 0.0077 15.9 0.2 0.022 14.4 0.0 1.9 3 0 0 3 3 3 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC36673.1 - 0.013 14.8 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF915 PF06028.11 EFC36673.1 - 0.035 13.5 0.0 0.14 11.4 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.13 EFC36673.1 - 0.086 12.5 0.1 0.34 10.6 0.0 1.9 1 1 1 2 2 2 0 PGAP1-like protein Palm_thioest PF02089.15 EFC36673.1 - 0.094 12.5 0.0 0.4 10.5 0.0 1.9 1 1 1 2 2 2 0 Palmitoyl protein thioesterase UDPGT PF00201.18 EFC36674.1 - 2.2e-12 46.5 0.0 4e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFC36674.1 - 0.00011 22.2 0.0 0.00022 21.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Peptidase_S10 PF00450.22 EFC36675.1 - 1.1e-83 282.0 6.1 2.7e-83 280.7 6.1 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase F-box-like PF12937.7 EFC36677.1 - 0.0032 17.3 0.1 0.016 15.0 0.0 2.4 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 EFC36677.1 - 0.038 14.4 15.3 0.97 9.9 0.0 6.7 7 0 0 7 7 7 0 Leucine Rich repeats (2 copies) PTR PF12789.7 EFC36677.1 - 0.048 13.7 3.2 1.4 9.0 0.4 2.9 2 0 0 2 2 2 0 Phage tail repeat like Colicin_im PF03857.13 EFC36678.1 - 0.065 13.2 1.2 0.12 12.3 1.2 1.5 1 0 0 1 1 1 0 Colicin immunity protein F-box-like PF12937.7 EFC36679.1 - 3e-06 27.0 0.4 6.9e-06 25.9 0.4 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC36679.1 - 0.00032 20.5 0.3 0.00092 19.0 0.3 1.7 1 0 0 1 1 1 1 F-box domain Citrate_synt PF00285.21 EFC36680.1 - 7.4e-133 443.1 0.0 8.9e-133 442.8 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain WD40 PF00400.32 EFC36681.1 - 1.2e-09 38.6 2.4 0.02 15.8 0.0 6.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36681.1 - 1.6e-05 25.1 4.9 0.067 13.5 0.1 5.6 3 1 4 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.7 EFC36681.1 - 9.1e-05 22.2 0.0 0.00049 19.9 0.0 2.4 2 0 0 2 2 2 1 Sec23-binding domain of Sec16 Clathrin PF00637.20 EFC36681.1 - 0.24 11.3 1.9 0.4 10.5 0.1 2.4 2 0 0 2 2 2 0 Region in Clathrin and VPS RCC1_2 PF13540.6 EFC36683.1 - 1.1e-30 104.8 19.8 7.8e-08 31.9 0.0 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC36683.1 - 8.4e-29 100.0 11.3 2.7e-06 27.9 0.0 7.4 8 1 0 8 8 8 5 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC36683.1 - 3.7e-05 23.9 3.7 7.7e-05 22.9 2.1 2.4 2 1 1 3 3 3 1 BTB/POZ domain G-alpha PF00503.20 EFC36684.1 - 4.3e-26 91.9 6.3 6.4e-26 91.3 6.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC36684.1 - 0.073 12.5 0.1 0.43 10.0 0.0 2.3 2 1 0 2 2 2 0 ADP-ribosylation factor family DUF917 PF06032.12 EFC36684.1 - 0.27 10.0 0.0 0.43 9.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF917) DUF5102 PF17104.5 EFC36685.1 - 1.2 9.1 8.7 6.3 6.7 1.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) Myb_DNA-bind_6 PF13921.6 EFC36687.1 - 6e-08 32.8 1.8 1.1e-06 28.8 0.9 3.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFC36687.1 - 0.0001 22.4 0.1 0.00029 21.0 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain HEAT PF02985.22 EFC36687.1 - 0.1 12.9 0.0 0.85 10.0 0.0 2.8 1 0 0 1 1 1 0 HEAT repeat TPP1 PF10341.9 EFC36687.1 - 0.12 12.4 0.6 0.5 10.4 0.6 2.1 1 0 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD SANT_DAMP1_like PF16282.5 EFC36687.1 - 0.2 11.9 1.3 0.46 10.7 0.0 2.4 2 0 0 2 2 2 0 SANT/Myb-like domain of DAMP1 ACDC PF14733.6 EFC36687.1 - 2.4 8.5 6.3 24 5.3 0.0 4.3 3 1 0 3 3 3 0 AP2-coincident C-terminal Rad10 PF03834.14 EFC36688.1 - 2.6e-22 79.0 3.1 1.6e-16 60.3 0.5 2.4 2 0 0 2 2 2 2 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 EFC36688.1 - 4.2e-05 24.1 0.0 8.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EFC36688.1 - 0.014 15.5 0.0 0.095 12.8 0.0 2.1 1 1 1 2 2 2 0 Helix-hairpin-helix motif MRP-L20 PF12824.7 EFC36688.1 - 1.4 9.1 10.4 5.2 7.2 10.4 2.1 1 1 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 BTB_2 PF02214.22 EFC36689.1 - 7.8e-11 42.2 0.4 0.0008 19.7 0.1 3.2 2 0 0 2 2 2 2 BTB/POZ domain NTP_transf_2 PF01909.23 EFC36689.1 - 0.072 13.4 1.3 0.34 11.2 0.1 2.9 2 0 0 2 2 2 0 Nucleotidyltransferase domain Polbeta PF18765.1 EFC36689.1 - 0.16 12.1 0.1 0.16 12.1 0.1 2.7 3 0 0 3 3 3 0 Polymerase beta, Nucleotidyltransferase DUF3421 PF11901.8 EFC36690.1 - 8.6e-07 29.0 5.1 9.7e-06 25.6 1.6 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3421) RNA_binding PF01877.17 EFC36690.1 - 0.0019 18.4 4.1 0.0086 16.4 0.6 3.7 4 1 0 4 4 4 1 RNA binding SLS PF14611.6 EFC36690.1 - 1.8 8.4 7.2 0.11 12.3 0.3 2.5 2 1 1 3 3 3 0 Mitochondrial inner-membrane-bound regulator DUF3580 PF12117.8 EFC36691.1 - 0.00024 21.3 0.4 0.0012 19.1 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3580) DUF4116 PF13475.6 EFC36692.1 - 4.3e-162 525.8 76.2 2.6e-15 55.9 0.2 23.9 8 6 15 27 27 27 26 Domain of unknown function (DUF4116) ENT PF03735.14 EFC36692.1 - 0.13 12.3 2.5 0.82 9.8 0.3 3.4 3 0 0 3 3 3 0 ENT domain G-alpha PF00503.20 EFC36693.1 - 7.4e-05 22.1 0.6 9.6e-05 21.7 0.6 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Chordopox_G2 PF05796.12 EFC36693.1 - 0.002 17.6 0.1 0.0035 16.8 0.1 1.3 1 0 0 1 1 1 1 Chordopoxvirus protein G2 ERK-JNK_inhib PF15002.6 EFC36693.1 - 0.0026 17.5 0.1 0.0046 16.7 0.1 1.4 1 0 0 1 1 1 1 ERK and JNK pathways, inhibitor AAA_16 PF13191.6 EFC36693.1 - 0.0041 17.5 0.0 0.0054 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFC36693.1 - 0.014 15.8 0.0 0.032 14.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFC36693.1 - 0.017 15.0 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain SRP54 PF00448.22 EFC36693.1 - 0.028 14.1 0.0 0.04 13.5 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Pox_A_type_inc PF04508.12 EFC36693.1 - 0.034 14.0 0.8 0.16 11.8 0.8 2.2 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat AAA_22 PF13401.6 EFC36693.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NuA4 PF09340.10 EFC36693.1 - 0.12 12.3 0.2 0.51 10.2 0.1 2.2 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 cobW PF02492.19 EFC36693.1 - 0.17 11.5 0.1 0.38 10.3 0.1 1.7 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain TPR_2 PF07719.17 EFC36694.1 - 1.6e-13 49.6 0.8 0.00025 20.9 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36694.1 - 2.6e-12 46.0 0.4 0.00028 20.6 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC36694.1 - 1.4e-07 31.7 0.1 0.00077 19.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Med15_fungi PF05397.12 EFC36694.1 - 0.00016 21.9 0.5 0.00016 21.9 0.5 1.8 2 0 0 2 2 2 1 Mediator complex subunit 15 TPR_11 PF13414.6 EFC36694.1 - 0.00099 18.7 0.0 4.2 7.1 0.0 3.5 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 EFC36694.1 - 0.0016 18.5 1.2 2.3 8.7 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC36694.1 - 0.0029 17.7 0.0 0.25 11.5 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC36694.1 - 0.0054 17.3 0.0 3.2 8.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC36694.1 - 0.031 14.3 0.1 1.5 9.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC36694.1 - 0.11 12.5 0.0 7.4 6.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Mucin PF01456.17 EFC36695.1 - 1.3 9.1 14.0 0.91 9.5 1.9 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein PI3_PI4_kinase PF00454.27 EFC36696.1 - 6.1e-40 137.6 0.9 7e-35 121.0 0.4 3.5 3 1 0 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC36696.1 - 1.8e-21 76.4 2.0 3.7e-21 75.4 2.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) T6SS_VipA PF05591.12 EFC36696.1 - 0.22 11.3 2.4 7.5 6.3 1.2 2.6 2 0 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 PIP49_C PF12260.8 EFC36697.1 - 0.16 11.6 5.9 0.03 14.0 2.6 1.4 1 1 0 1 1 1 0 Protein-kinase domain of FAM69 Fz PF01392.22 EFC36697.1 - 0.96 10.1 13.9 2.3 8.9 14.0 1.6 1 1 0 1 1 1 0 Fz domain FRG2 PF15315.6 EFC36698.1 - 1.2 9.3 5.9 0.11 12.7 1.7 1.5 2 0 0 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 Casc1_N PF15927.5 EFC36700.1 - 0.0037 17.0 1.0 0.0055 16.4 1.0 1.2 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 N-terminus AT_hook PF02178.19 EFC36700.1 - 0.56 10.3 6.6 1.1 9.4 6.6 1.5 1 0 0 1 1 1 0 AT hook motif LRR_6 PF13516.6 EFC36701.1 - 3e-59 192.1 16.7 0.00015 21.5 0.1 12.0 12 0 0 12 12 12 12 Leucine Rich repeat LRR_8 PF13855.6 EFC36701.1 - 4.9e-33 112.7 22.2 7.4e-06 25.6 0.5 5.3 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC36701.1 - 7.9e-31 105.6 8.1 0.00046 20.5 0.0 7.0 3 1 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36701.1 - 1.1e-16 58.7 0.1 2.3 9.1 0.0 11.0 12 0 0 12 12 12 3 Leucine Rich Repeat RYDR_ITPR PF01365.21 EFC36702.1 - 2.4e-26 92.4 18.7 1.2e-16 60.8 5.2 4.2 3 0 0 3 3 3 2 RIH domain RIH_assoc PF08454.11 EFC36702.1 - 7.4e-20 70.7 1.9 7.4e-20 70.7 1.9 8.0 7 1 0 7 7 7 2 RyR and IP3R Homology associated Ins145_P3_rec PF08709.11 EFC36702.1 - 2e-19 69.6 6.5 1.3e-18 67.0 2.9 3.4 2 2 1 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 EFC36702.1 - 1.6e-12 47.7 1.3 2.5e-09 37.3 0.1 3.2 2 0 0 2 2 2 2 MIR domain Ion_trans PF00520.31 EFC36702.1 - 0.019 14.2 33.1 0.0051 16.1 28.2 2.6 2 1 0 2 2 2 0 Ion transport protein DNA_pol3_beta_3 PF02768.15 EFC36702.1 - 1.6 8.5 7.2 0.2 11.5 1.5 2.4 3 0 0 3 3 3 0 DNA polymerase III beta subunit, C-terminal domain PP-binding PF00550.25 EFC36703.1 - 2.9e-09 37.2 0.1 3.7e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EFC36703.1 - 0.0062 16.7 0.2 0.0075 16.5 0.2 1.2 1 0 0 1 1 1 1 Acyl-carrier HALZ PF02183.18 EFC36704.1 - 0.0044 17.2 0.5 0.012 15.8 0.5 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF4600 PF15372.6 EFC36704.1 - 0.78 10.2 16.1 0.68 10.4 0.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4600) RabGAP-TBC PF00566.18 EFC36705.1 - 4.2e-41 141.0 11.7 3.4e-23 82.5 0.0 2.9 3 0 0 3 3 3 2 Rab-GTPase-TBC domain Macoilin PF09726.9 EFC36705.1 - 0.019 13.6 12.3 0.03 12.9 12.3 1.3 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 EFC36705.1 - 0.076 13.6 8.8 0.14 12.8 8.8 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Trypsin PF00089.26 EFC36706.1 - 1.1e-43 149.7 0.0 1.3e-43 149.4 0.0 1.0 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC36706.1 - 2.6e-06 28.4 0.0 4.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF316 PF03761.15 EFC36706.1 - 0.033 13.8 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 Chymotrypsin family Peptidase-S1 F-box PF00646.33 EFC36707.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 F-box domain PRANC PF09372.10 EFC36707.1 - 0.032 14.6 0.3 0.16 12.3 0.0 2.3 1 1 2 3 3 3 0 PRANC domain Triabin PF03973.13 EFC36707.1 - 0.086 12.7 0.8 0.17 11.8 0.6 1.6 1 1 1 2 2 2 0 Triabin PEPCK_N PF17297.2 EFC36707.1 - 0.12 12.0 0.5 0.15 11.6 0.5 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain F-box-like PF12937.7 EFC36707.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 F-box-like Phospholip_A2_1 PF00068.19 EFC36709.1 - 0.076 13.5 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Phospholipase A2 DnaJ PF00226.31 EFC36710.1 - 4.2e-20 71.6 1.3 8.2e-20 70.7 0.1 2.0 2 1 0 2 2 2 1 DnaJ domain Corona_nucleoca PF00937.18 EFC36710.1 - 0.0094 15.0 1.5 0.011 14.8 1.5 1.1 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein MRI PF15325.6 EFC36710.1 - 0.013 16.6 1.9 0.03 15.4 1.9 1.6 1 0 0 1 1 1 0 Modulator of retrovirus infection Macoilin PF09726.9 EFC36710.1 - 0.92 8.0 10.0 0.95 7.9 10.0 1.1 1 0 0 1 1 1 0 Macoilin family NAM-associated PF14303.6 EFC36710.1 - 9.1 7.0 12.0 8 7.2 10.9 1.4 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Homeobox_KN PF05920.11 EFC36711.1 - 6.9e-15 54.7 0.2 1.6e-14 53.5 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC36711.1 - 3.6e-07 29.9 0.9 9.7e-07 28.5 0.9 1.8 1 0 0 1 1 1 1 Homeodomain SAP18 PF06487.12 EFC36711.1 - 0.71 10.1 4.6 1.3 9.2 4.5 1.5 1 1 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) adh_short PF00106.25 EFC36712.1 - 1.1e-23 83.7 1.2 2.1e-22 79.6 0.7 2.4 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36712.1 - 4.5e-13 49.3 0.0 8.3e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase GDP_Man_Dehyd PF16363.5 EFC36712.1 - 0.0015 18.0 0.1 0.002 17.6 0.1 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EFC36712.1 - 0.053 13.4 0.0 0.1 12.5 0.0 1.6 1 1 0 1 1 1 0 KR domain DUF4116 PF13475.6 EFC36713.1 - 4.8e-75 247.1 19.4 5e-17 61.4 1.3 7.1 3 2 4 7 7 7 7 Domain of unknown function (DUF4116) AAA PF00004.29 EFC36714.1 - 8.4e-19 68.3 0.0 4.6e-18 65.9 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EFC36714.1 - 8e-08 32.5 0.6 4.7e-05 23.5 0.2 2.3 2 0 0 2 2 2 2 BCS1 N terminal AAA_5 PF07728.14 EFC36714.1 - 0.00043 20.3 0.0 0.001 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC36714.1 - 0.0016 18.9 0.0 0.003 18.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 EFC36714.1 - 0.0017 18.7 0.2 0.018 15.4 0.2 2.7 1 1 0 1 1 1 1 RNA helicase RuvB_N PF05496.12 EFC36714.1 - 0.0042 16.9 0.0 0.0078 16.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 EFC36714.1 - 0.0077 16.2 0.2 0.025 14.5 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFC36714.1 - 0.018 14.6 0.0 0.035 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region CbiA PF01656.23 EFC36714.1 - 0.02 15.0 0.0 0.052 13.6 0.0 1.7 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_6 PF12774.7 EFC36714.1 - 0.021 13.8 0.0 0.056 12.4 0.0 1.7 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region ATPase PF06745.13 EFC36714.1 - 0.025 13.9 0.0 0.053 12.9 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_25 PF13481.6 EFC36714.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFC36714.1 - 0.039 13.9 0.3 0.15 12.0 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_24 PF13479.6 EFC36714.1 - 0.045 13.5 0.0 0.093 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC36714.1 - 0.048 13.9 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EFC36714.1 - 0.072 13.0 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFC36714.1 - 0.1 13.1 0.1 0.51 10.8 0.1 2.2 1 1 0 1 1 1 0 ABC transporter AAA_11 PF13086.6 EFC36714.1 - 0.1 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EFC36714.1 - 0.11 12.3 0.0 0.61 9.8 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EFC36714.1 - 0.11 11.7 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_19 PF13245.6 EFC36714.1 - 0.12 12.7 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFC36714.1 - 0.65 10.5 3.9 0.19 12.2 0.7 1.8 2 1 0 2 2 2 0 AAA domain ATP-synt_D PF01813.17 EFC36717.1 - 1.4e-55 188.2 8.2 1.7e-55 187.9 8.2 1.0 1 0 0 1 1 1 1 ATP synthase subunit D MatP_C PF17414.2 EFC36717.1 - 0.066 13.4 1.9 14 5.9 0.5 3.0 1 1 1 2 2 2 0 MatP C-terminal ribbon-helix-helix domain DUF1054 PF06335.12 EFC36717.1 - 0.09 12.7 1.4 0.21 11.5 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1054) BTB PF00651.31 EFC36718.1 - 7.3e-13 48.7 0.1 2.9e-12 46.8 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain Fapy_DNA_glyco PF01149.24 EFC36718.1 - 0.033 14.8 0.0 0.077 13.6 0.0 1.6 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase N-terminal domain Pkinase PF00069.25 EFC36719.1 - 1.8e-49 168.5 0.0 2.9e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain EGF_2 PF07974.13 EFC36719.1 - 2.5e-30 104.5 146.3 6.3e-05 23.3 9.8 9.5 9 0 0 9 9 9 9 EGF-like domain Pkinase_Tyr PF07714.17 EFC36719.1 - 1.1e-29 103.5 0.0 1.9e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC36719.1 - 0.00011 21.1 0.0 0.00025 20.0 0.0 1.5 1 1 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EFC36719.1 - 0.0023 17.8 0.9 0.0023 17.8 0.9 2.1 2 0 0 2 2 2 1 TMEM154 protein family Stevor PF17410.2 EFC36719.1 - 0.014 14.9 5.3 0.042 13.4 0.7 2.9 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame EGF PF00008.27 EFC36719.1 - 0.015 15.6 103.7 0.13 12.6 2.3 9.7 9 0 0 9 9 9 0 EGF-like domain Chordopox_A13L PF05961.11 EFC36719.1 - 0.029 14.6 0.4 0.074 13.3 0.4 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein RIFIN PF02009.16 EFC36719.1 - 0.22 11.3 1.6 0.8 9.5 1.6 2.0 1 0 0 1 1 1 0 Rifin ODV-E18 PF10717.9 EFC36719.1 - 0.6 10.0 10.6 0.055 13.3 3.4 3.0 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 RGS PF00615.19 EFC36720.1 - 1.1e-06 28.9 4.0 1.4e-05 25.3 0.2 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain SPG48 PF14764.6 EFC36721.1 - 0.066 13.7 0.4 1.1 9.7 0.0 3.2 3 0 0 3 3 3 0 AP-5 complex subunit, vesicle trafficking CPG4 PF15481.6 EFC36721.1 - 0.11 13.2 0.2 0.46 11.1 0.2 2.1 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 Imm53 PF15580.6 EFC36722.1 - 0.068 12.9 0.3 1.8 8.3 0.1 2.4 2 0 0 2 2 2 0 Immunity protein 53 DUF4598 PF15370.6 EFC36722.1 - 3.2 8.3 5.9 30 5.1 2.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4598) Pkinase PF00069.25 EFC36723.1 - 8.5e-43 146.6 0.0 1.6e-42 145.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36723.1 - 2.7e-25 89.1 0.0 5.2e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC36723.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC36723.1 - 0.03 13.9 0.1 0.08 12.5 0.1 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EFC36723.1 - 0.076 11.8 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase TauE PF01925.19 EFC36724.1 - 0.063 12.9 2.6 0.11 12.2 2.6 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE Pkinase PF00069.25 EFC36725.1 - 5e-34 117.9 1.7 6.8e-34 117.4 0.3 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36725.1 - 1e-31 110.2 0.2 1.5e-31 109.6 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC36725.1 - 0.0075 15.1 0.1 0.011 14.5 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC36725.1 - 0.023 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family CPSase_L_D2 PF02786.17 EFC36726.1 - 2e-78 262.7 0.2 3.4e-78 262.0 0.2 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 EFC36726.1 - 1.5e-56 191.3 0.3 5.8e-55 186.1 0.2 2.8 2 1 0 2 2 2 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 EFC36726.1 - 2.2e-40 137.6 0.0 4.3e-40 136.7 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFC36726.1 - 3.2e-33 114.1 0.0 2.9e-31 107.8 0.0 2.6 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 EFC36726.1 - 2.8e-30 105.8 0.0 9.2e-30 104.1 0.0 1.9 2 0 0 2 2 2 1 HMGL-like Biotin_lipoyl PF00364.22 EFC36726.1 - 6.9e-17 61.1 3.8 1.6e-16 59.9 3.8 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 EFC36726.1 - 8.9e-10 38.4 0.1 2.3e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EFC36726.1 - 1.6e-09 37.4 3.8 3.4e-05 23.6 0.5 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 EFC36726.1 - 1.5e-08 34.4 0.0 2.7e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFC36726.1 - 0.001 19.1 0.0 0.0025 17.9 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 EFC36726.1 - 0.0028 16.9 0.2 0.42 9.8 0.0 2.7 2 1 1 3 3 3 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATPgrasp_ST PF14397.6 EFC36726.1 - 0.0048 16.2 0.0 0.01 15.1 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 EFC36726.1 - 0.014 15.0 0.1 0.035 13.7 0.1 1.7 1 0 0 1 1 1 0 ATP-grasp domain PYNP_C PF07831.13 EFC36726.1 - 0.081 12.6 1.4 5.3 6.8 0.1 2.9 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain DUF3182 PF11379.8 EFC36726.1 - 0.095 11.6 0.0 0.16 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) HlyD_3 PF13437.6 EFC36726.1 - 0.11 13.3 0.2 16 6.3 0.0 3.7 4 0 0 4 4 2 0 HlyD family secretion protein ATPgrasp_Ter PF15632.6 EFC36726.1 - 0.11 12.3 0.4 0.72 9.6 0.0 2.4 3 0 0 3 3 3 0 ATP-grasp in the biosynthetic pathway with Ter operon PTS_EIIA_1 PF00358.20 EFC36726.1 - 0.19 11.5 0.8 0.82 9.4 0.2 2.4 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 EGF_2 PF07974.13 EFC36728.1 - 9.4e-50 166.7 319.7 0.00011 22.5 9.9 19.0 19 0 0 19 19 19 18 EGF-like domain Pkinase PF00069.25 EFC36728.1 - 1.5e-49 168.8 2.5 2.3e-49 168.2 2.5 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36728.1 - 3.6e-30 105.1 0.5 6.1e-30 104.4 0.5 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC36728.1 - 1.5e-07 31.1 0.0 4.4 7.5 0.0 5.8 5 0 0 5 5 5 3 NHL repeat TMEM154 PF15102.6 EFC36728.1 - 0.00018 21.4 0.4 0.00054 19.9 0.4 1.8 1 0 0 1 1 1 1 TMEM154 protein family RIFIN PF02009.16 EFC36728.1 - 0.0004 20.4 3.2 0.0012 18.9 3.2 1.8 1 0 0 1 1 1 1 Rifin Pkinase_fungal PF17667.1 EFC36728.1 - 0.051 12.3 0.1 0.096 11.4 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase Corona_NSP4_C PF16348.5 EFC36728.1 - 0.072 13.9 0.2 0.84 10.5 0.0 2.8 2 0 0 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus Ferric_reduct PF01794.19 EFC36729.1 - 2.6e-18 66.4 7.6 5.3e-18 65.3 7.6 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component DOMON PF03351.17 EFC36729.1 - 6.4e-18 65.2 1.0 1.4e-16 60.8 0.4 2.7 2 0 0 2 2 2 1 DOMON domain NAD_binding_6 PF08030.12 EFC36729.1 - 9.8e-10 38.8 1.2 3.2e-09 37.1 0.1 2.5 3 0 0 3 3 3 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC36729.1 - 1.1e-05 25.5 0.1 2.7e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFC36729.1 - 0.00033 21.3 0.1 0.0017 19.0 0.1 2.3 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain PhoLip_ATPase_C PF16212.5 EFC36730.1 - 1.7e-82 277.0 26.8 1.7e-82 277.0 26.8 2.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC36730.1 - 3e-26 90.9 8.5 3e-26 90.9 8.5 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFC36730.1 - 1.2e-12 47.7 0.0 5.8e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC36730.1 - 3.7e-10 40.5 0.0 6.7e-07 29.8 0.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFC36730.1 - 1.4e-08 34.5 0.0 4.4e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFC36730.1 - 0.026 14.3 0.2 0.026 14.3 0.2 2.7 4 0 0 4 4 4 0 haloacid dehalogenase-like hydrolase Pkinase PF00069.25 EFC36731.1 - 2e-42 145.4 3.6 1.1e-41 142.9 2.9 2.7 1 1 1 2 2 2 1 Protein kinase domain Kelch_4 PF13418.6 EFC36731.1 - 5.4e-31 106.4 4.3 1.3e-06 28.3 0.0 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Pkinase_Tyr PF07714.17 EFC36731.1 - 5.5e-29 101.2 1.9 6.1e-27 94.5 1.9 2.8 2 1 0 2 2 2 1 Protein tyrosine kinase Kelch_5 PF13854.6 EFC36731.1 - 1.3e-26 92.0 0.9 8.4e-05 22.5 0.0 7.4 7 0 0 7 7 7 5 Kelch motif Kelch_6 PF13964.6 EFC36731.1 - 2e-20 72.3 2.8 8.9e-05 22.6 0.0 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFC36731.1 - 6.3e-17 60.8 7.2 3.8e-05 23.5 0.1 6.2 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFC36731.1 - 1.8e-16 59.9 5.2 0.017 15.4 0.0 8.6 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC36731.1 - 2.4e-11 43.0 0.2 0.011 15.3 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Phe_tRNA-synt_N PF02912.18 EFC36731.1 - 0.12 12.3 0.5 0.4 10.6 0.5 1.8 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain Kdo PF06293.14 EFC36731.1 - 0.13 11.6 0.0 0.33 10.3 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family EHD_N PF16880.5 EFC36732.1 - 0.015 15.2 0.1 0.048 13.6 0.1 2.0 1 0 0 1 1 1 0 N-terminal EH-domain containing protein Y_phosphatase2 PF03162.13 EFC36733.1 - 3e-53 179.8 0.0 3.6e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFC36733.1 - 6.6e-09 36.1 0.0 7.5e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 EFC36733.1 - 0.00028 20.7 0.0 0.00029 20.6 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC36733.1 - 0.00043 19.9 0.0 0.00049 19.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Guanylate_cyc PF00211.20 EFC36734.1 - 8.6e-51 172.2 0.7 1.7e-50 171.2 0.7 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC36734.1 - 9.9e-16 57.8 0.0 4.2e-09 36.4 0.1 2.4 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC36734.1 - 2.7e-12 46.8 0.7 3.6e-09 36.8 0.2 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EFC36734.1 - 4.7e-06 26.8 0.0 0.007 16.6 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 EFC36734.1 - 1.4e-05 24.9 0.0 0.023 14.7 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 EFC36734.1 - 0.0054 17.0 0.0 0.014 15.7 0.0 1.7 2 0 0 2 2 2 1 PAS fold MLTR_LBD PF17765.1 EFC36734.1 - 0.063 13.4 0.0 9.7 6.3 0.0 2.2 2 0 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain Sel1 PF08238.12 EFC36735.1 - 1.1e-55 184.8 10.3 2.4e-09 37.5 0.0 6.1 6 0 0 6 6 6 6 Sel1 repeat TPR_6 PF13174.6 EFC36735.1 - 1.6e-07 31.5 4.5 0.17 12.6 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC36735.1 - 0.0049 16.5 18.6 1.4 8.7 0.0 6.7 7 1 0 7 7 7 2 TPR repeat DUF3837 PF12939.7 EFC36735.1 - 0.01 16.2 0.7 1.9 8.9 0.0 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3837) TPR_7 PF13176.6 EFC36735.1 - 0.022 14.7 2.2 4.5 7.5 0.1 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF977 PF06163.11 EFC36735.1 - 0.033 14.1 0.0 0.17 11.8 0.0 2.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF977) TPR_2 PF07719.17 EFC36735.1 - 0.034 14.3 18.7 2.7 8.3 0.3 7.8 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36735.1 - 0.16 11.9 27.7 1.6 8.7 0.2 8.6 11 0 0 11 11 11 0 Tetratricopeptide repeat NHL PF01436.21 EFC36736.1 - 1.1e-24 85.1 0.8 0.0017 18.3 0.0 9.6 11 0 0 11 11 11 5 NHL repeat EGF_2 PF07974.13 EFC36736.1 - 1.5e-09 38.1 62.2 0.006 16.9 9.9 5.0 5 0 0 5 5 5 4 EGF-like domain SGL PF08450.12 EFC36736.1 - 1.2e-05 25.1 2.8 1.3 8.6 0.2 4.8 3 2 1 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC36736.1 - 0.0031 17.7 5.1 2.9 8.2 0.0 5.1 5 0 0 5 5 5 1 Arylesterase DUF3997 PF13162.6 EFC36736.1 - 0.0034 17.7 1.8 0.0093 16.3 0.8 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3997) Virul_fac_BrkB PF03631.15 EFC36736.1 - 0.0056 16.3 0.7 0.14 11.8 0.2 2.1 2 0 0 2 2 2 1 Virulence factor BrkB SBBP PF06739.11 EFC36736.1 - 0.73 9.9 6.4 1.1 9.3 0.3 3.6 3 0 0 3 3 3 0 Beta-propeller repeat SHP PF03579.13 EFC36736.1 - 1.1 9.3 8.0 0.33 10.9 0.8 2.5 2 0 0 2 2 2 0 Small hydrophobic protein AT_hook PF02178.19 EFC36737.1 - 0.026 14.4 4.8 0.064 13.1 4.8 1.7 1 0 0 1 1 1 0 AT hook motif Abhydrolase_4 PF08386.10 EFC36737.1 - 0.076 13.1 0.1 0.4 10.8 0.0 2.1 2 0 0 2 2 2 0 TAP-like protein RGS PF00615.19 EFC36738.1 - 5.6e-09 36.3 1.2 2e-08 34.5 0.4 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF962 PF06127.11 EFC36739.1 - 0.018 15.1 1.4 0.82 9.8 0.0 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF962) SUa-2TM PF18179.1 EFC36741.1 - 0.019 14.2 0.2 0.029 13.7 0.2 1.3 1 0 0 1 1 1 0 SMODS- and Ubiquitin system-associated 2TM effector domain Fz PF01392.22 EFC36743.1 - 0.0005 20.7 6.1 0.0005 20.7 6.1 2.1 1 1 1 2 2 2 1 Fz domain DUF4344 PF14247.6 EFC36743.1 - 0.08 12.6 2.6 0.065 12.9 1.3 1.3 1 1 0 1 1 1 0 Putative metallopeptidase tRNA-synt_1c PF00749.21 EFC36745.1 - 1.7e-106 355.7 1.0 2.8e-106 355.0 1.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFC36745.1 - 2e-45 154.8 0.1 4.4e-45 153.7 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 PF04558.15 EFC36745.1 - 9.4e-28 97.2 0.1 9.4e-28 97.2 0.1 1.8 2 0 0 2 2 2 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Med28 PF11594.8 EFC36745.1 - 0.035 14.2 0.6 0.53 10.4 0.0 3.1 3 1 1 4 4 4 0 Mediator complex subunit 28 TPH PF13868.6 EFC36746.1 - 7.7e-13 47.7 160.2 7.7e-13 47.7 160.2 2.0 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain PH PF00169.29 EFC36747.1 - 0.24 12.0 3.8 1.4 9.4 0.1 3.3 3 0 0 3 3 3 0 PH domain FH2 PF02181.23 EFC36748.1 - 8.5e-76 255.5 17.2 8.5e-76 255.5 17.2 2.9 4 1 1 5 5 5 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFC36748.1 - 2.3e-18 66.4 1.0 2.3e-18 66.4 1.0 3.1 4 1 0 4 4 4 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFC36748.1 - 1.1e-14 54.5 0.8 1.1e-14 54.5 0.8 3.6 2 2 0 2 2 2 1 Diaphanous FH3 Domain DUF3800 PF12686.7 EFC36748.1 - 0.0071 17.0 0.0 3.7 8.2 0.0 3.9 2 2 0 2 2 2 1 Protein of unknown function (DUF3800) FOXP-CC PF16159.5 EFC36748.1 - 0.76 10.4 5.2 0.62 10.7 1.6 2.8 2 1 1 3 3 3 0 FOXP coiled-coil domain WXG100 PF06013.12 EFC36748.1 - 1.7 8.9 6.7 6.4 7.1 0.3 3.0 2 0 0 2 2 2 0 Proteins of 100 residues with WXG CortBP2 PF09727.9 EFC36748.1 - 2.3 8.1 24.4 0.26 11.2 6.5 3.5 3 0 0 3 3 3 0 Cortactin-binding protein-2 DUF2730 PF10805.8 EFC36748.1 - 7.7 6.7 9.0 11 6.1 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2730) SlyX PF04102.12 EFC36748.1 - 9.4 6.9 8.4 6.1 7.5 1.2 3.5 2 0 0 2 2 2 0 SlyX Ank_2 PF12796.7 EFC36749.1 - 1.3e-11 45.0 2.6 0.00025 21.6 0.1 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC36749.1 - 1.5e-08 34.2 3.0 0.023 15.2 0.0 5.9 7 0 0 7 7 7 2 Ankyrin repeat Ank_4 PF13637.6 EFC36749.1 - 6e-05 23.5 0.2 0.97 10.1 0.0 4.6 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC36749.1 - 0.025 14.9 0.0 2.3 8.7 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.30 EFC36749.1 - 0.1 13.1 4.8 76 4.0 0.0 5.2 6 0 0 6 6 6 0 Ankyrin repeat Nop14 PF04147.12 EFC36750.1 - 0.00062 18.1 12.5 0.00081 17.7 12.5 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 EFC36750.1 - 0.00065 19.2 9.5 0.00084 18.9 9.5 1.1 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 EFC36750.1 - 0.00078 17.9 6.2 0.00095 17.6 6.2 1.1 1 0 0 1 1 1 1 CDC45-like protein RCC1_2 PF13540.6 EFC36750.1 - 0.0031 17.2 0.2 1.7 8.6 0.0 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RRN3 PF05327.11 EFC36750.1 - 0.0034 16.0 5.6 0.0044 15.6 5.6 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF913 PF06025.12 EFC36750.1 - 0.036 13.1 0.3 0.05 12.6 0.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NOA36 PF06524.12 EFC36750.1 - 0.059 12.7 7.1 0.13 11.6 7.1 1.6 1 0 0 1 1 1 0 NOA36 protein Nop53 PF07767.11 EFC36750.1 - 0.23 10.8 16.8 0.32 10.3 16.8 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Trypan_PARP PF05887.11 EFC36750.1 - 0.31 11.0 11.2 0.53 10.3 11.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RNA_pol_Rpc4 PF05132.14 EFC36750.1 - 0.35 11.3 2.2 0.64 10.4 2.2 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 EFC36750.1 - 0.61 10.2 6.3 1.1 9.4 6.3 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Saw1 PF11561.8 EFC36750.1 - 3.2 7.2 8.8 6.2 6.3 8.8 1.4 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Presenilin PF01080.17 EFC36750.1 - 6.5 5.4 7.2 9.6 4.8 7.2 1.1 1 0 0 1 1 1 0 Presenilin RGS PF00615.19 EFC36752.1 - 3.8e-09 36.8 1.9 6.8e-09 36.0 1.9 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC36752.1 - 0.0094 15.7 0.8 0.017 14.8 0.8 1.4 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain R3H-assoc PF13902.6 EFC36752.1 - 0.05 14.0 2.7 0.11 12.9 2.7 1.5 1 0 0 1 1 1 0 R3H-associated N-terminal domain NRN1 PF15056.6 EFC36752.1 - 0.07 13.2 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Neuritin protein family Latarcin PF10279.9 EFC36752.1 - 0.078 13.4 0.2 0.2 12.1 0.2 1.6 1 0 0 1 1 1 0 Latarcin precursor LRR_6 PF13516.6 EFC36753.1 - 1.6e-11 43.3 12.6 3.6e-05 23.5 0.0 6.8 7 0 0 7 7 7 4 Leucine Rich repeat LRR_4 PF12799.7 EFC36753.1 - 8.6e-10 38.7 36.3 0.021 15.2 1.6 8.5 4 3 2 7 7 7 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC36753.1 - 0.00072 19.4 0.3 0.002 18.0 0.3 1.8 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.13 EFC36753.1 - 0.019 15.6 1.3 0.4 11.4 0.1 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat FTH PF01827.27 EFC36753.1 - 0.31 10.8 5.9 14 5.5 0.3 3.6 2 1 1 3 3 3 0 FTH domain LRR_8 PF13855.6 EFC36753.1 - 0.54 10.1 24.1 0.084 12.7 1.8 7.0 6 4 1 7 7 7 0 Leucine rich repeat LRR_1 PF00560.33 EFC36753.1 - 0.56 11.0 26.4 6.4 7.7 0.0 8.1 8 1 0 8 8 8 0 Leucine Rich Repeat BTB_2 PF02214.22 EFC36754.1 - 1.7e-20 73.1 0.1 3e-20 72.3 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.28 EFC36754.1 - 0.00011 22.3 0.1 0.00017 21.6 0.1 1.3 1 0 0 1 1 1 1 SPRY domain VWA_3 PF13768.6 EFC36755.1 - 2.8e-36 124.8 0.0 3.9e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC36755.1 - 0.0025 18.1 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain RRM_1 PF00076.22 EFC36755.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_C25_C PF03785.14 EFC36755.1 - 0.019 14.8 0.5 0.037 13.9 0.5 1.4 1 0 0 1 1 1 0 Peptidase family C25, C terminal ig-like domain Pox_E8 PF03394.13 EFC36757.1 - 0.007 16.0 0.8 0.083 12.4 0.8 2.0 1 1 0 1 1 1 1 Poxvirus E8 protein Reticulon PF02453.17 EFC36757.1 - 0.0083 16.1 1.6 0.018 15.0 1.4 1.5 1 1 1 2 2 2 1 Reticulon EMC3_TMCO1 PF01956.16 EFC36757.1 - 0.029 14.1 0.3 0.037 13.8 0.3 1.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Brr6_like_C_C PF10104.9 EFC36757.1 - 0.21 11.4 2.1 0.25 11.1 0.7 1.8 1 1 1 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain PhoR PF11808.8 EFC36757.1 - 9.5 6.7 7.6 23 5.5 7.6 1.5 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR RGS PF00615.19 EFC36758.1 - 9.7e-11 42.0 0.2 7e-10 39.2 0.0 2.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain Lipase_GDSL_3 PF14606.6 EFC36758.1 - 0.1 12.7 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family DEAD PF00270.29 EFC36759.1 - 1.9e-38 132.0 0.1 2.7e-38 131.5 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC36759.1 - 0.0011 19.0 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Guanylate_cyc PF00211.20 EFC36760.1 - 1.9e-32 112.4 0.0 3.2e-32 111.6 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC36760.1 - 9.7e-06 25.5 5.8 1.5e-05 24.9 5.8 1.2 1 0 0 1 1 1 1 Cache domain Baculo_11_kDa PF06143.11 EFC36760.1 - 0.68 9.5 8.6 0.8 9.3 3.9 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family LapA_dom PF06305.11 EFC36760.1 - 5.6 6.9 8.5 20 5.1 0.3 2.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF917 PF06032.12 EFC36761.1 - 1.4e-44 152.4 0.1 1.8e-44 152.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF917) F-box-like PF12937.7 EFC36762.1 - 4.1e-06 26.6 0.8 8.8e-06 25.5 0.4 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC36762.1 - 0.00071 19.4 0.2 0.0017 18.1 0.2 1.6 1 0 0 1 1 1 1 F-box domain RAMPs PF03787.15 EFC36762.1 - 0.016 15.3 0.7 0.026 14.6 0.7 1.5 1 1 0 1 1 1 0 RAMP superfamily TPR_2 PF07719.17 EFC36762.1 - 0.39 11.0 5.8 73 3.9 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Trypan_PARP PF05887.11 EFC36763.1 - 1.4e-06 28.4 70.4 0.00071 19.6 35.3 2.1 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) ApoO PF09769.9 EFC36764.1 - 0.41 10.6 2.3 21 5.1 0.0 2.8 3 0 0 3 3 3 0 Apolipoprotein O Exonuc_VII_L PF02601.15 EFC36764.1 - 1.1 8.7 12.7 1.2 8.7 4.0 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF3800 PF12686.7 EFC36764.1 - 1.7 9.3 7.4 1.2e+02 3.3 7.4 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF1515 PF07439.11 EFC36764.1 - 5.9 7.0 6.5 6.9 6.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) RecG_N PF17190.4 EFC36764.1 - 7.5 7.4 19.8 1.3 9.8 6.8 3.6 2 1 1 4 4 4 0 RecG N-terminal helical domain FliJ PF02050.16 EFC36764.1 - 7.7 6.8 13.3 1.1 9.4 1.4 3.0 2 2 1 3 3 3 0 Flagellar FliJ protein Prefoldin_2 PF01920.20 EFC36764.1 - 9.4 6.2 30.0 0.56 10.2 1.7 4.2 3 1 1 4 4 4 0 Prefoldin subunit PBC PF03792.13 EFC36765.1 - 0.071 12.9 2.9 0.12 12.1 2.9 1.3 1 0 0 1 1 1 0 PBC domain LRR_4 PF12799.7 EFC36766.1 - 0.00012 22.4 18.8 0.0025 18.2 0.9 5.8 4 2 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36766.1 - 0.0003 20.5 2.4 0.0003 20.5 2.4 3.6 5 0 0 5 5 5 1 Leucine rich repeat F-box-like PF12937.7 EFC36766.1 - 0.053 13.4 0.0 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 F-box-like Pentapeptide PF00805.22 EFC36767.1 - 9e-38 127.5 56.1 1.3e-10 40.7 7.3 11.0 5 4 3 9 9 9 8 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC36767.1 - 1.3e-36 124.6 73.7 2.4e-12 46.8 5.8 6.9 2 2 4 7 7 7 7 Pentapeptide repeats (9 copies) TLD PF07534.16 EFC36767.1 - 3.3e-20 72.7 3.6 3.3e-20 72.7 3.6 2.8 3 0 0 3 3 3 1 TLD Pentapeptide_3 PF13576.6 EFC36767.1 - 4.8e-20 71.5 62.8 3.1e-07 30.4 2.8 10.1 4 2 6 10 10 10 7 Pentapeptide repeats (9 copies) BTB PF00651.31 EFC36767.1 - 7.9e-05 22.8 0.4 0.0003 21.0 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain zf-RING_2 PF13639.6 EFC36767.1 - 0.0018 18.5 9.1 0.0018 18.5 9.1 3.2 4 0 0 4 4 3 1 Ring finger domain BTB_2 PF02214.22 EFC36767.1 - 0.006 16.9 0.0 0.026 14.9 0.0 2.2 1 0 0 1 1 1 1 BTB/POZ domain V-ATPase_G PF03179.15 EFC36767.1 - 0.022 15.3 9.9 0.075 13.6 9.9 1.9 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Exonuc_VII_L PF02601.15 EFC36767.1 - 0.068 12.7 6.4 0.14 11.7 6.4 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C3HC4_4 PF15227.6 EFC36767.1 - 0.51 10.6 10.7 0.13 12.5 5.7 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFC36767.1 - 0.57 10.1 16.3 0.1 12.4 9.8 3.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC36767.1 - 0.67 10.0 10.8 0.14 12.3 6.3 2.4 2 1 0 2 2 1 0 RING-type zinc-finger zf-BED PF02892.15 EFC36767.1 - 0.74 9.9 7.2 10 6.2 0.2 3.9 3 0 0 3 3 2 0 BED zinc finger CfAFP PF05264.11 EFC36767.1 - 2.4 8.1 19.3 1.9 8.5 0.1 4.8 1 1 4 5 5 5 0 Choristoneura fumiferana antifreeze protein (CfAFP) zf-RING_10 PF16685.5 EFC36767.1 - 5.9 7.1 13.9 14 5.9 11.7 2.8 2 1 1 3 3 3 0 zinc RING finger of MSL2 OmpH PF03938.14 EFC36767.1 - 7 7.0 19.6 16 5.8 19.6 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) BTB PF00651.31 EFC36768.1 - 6.1e-07 29.7 0.2 1.2e-06 28.7 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain Guanylate_cyc PF00211.20 EFC36769.1 - 7.5e-05 22.4 1.2 0.00014 21.5 1.2 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pilin_N PF07790.11 EFC36769.1 - 6 7.9 7.0 17 6.4 0.0 3.1 3 0 0 3 3 3 0 Archaeal Type IV pilin, N-terminal ABC_tran PF00005.27 EFC36770.1 - 3.9e-17 63.1 0.1 8.4e-17 62.0 0.1 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EFC36770.1 - 1.4e-10 41.0 2.2 1.4e-10 41.0 2.2 2.0 2 0 0 2 2 2 1 ABC-2 type transporter OAD_gamma PF04277.13 EFC36770.1 - 0.0089 16.6 0.0 0.018 15.6 0.0 1.5 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain DUF4834 PF16118.5 EFC36770.1 - 0.043 14.8 0.1 0.1 13.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF463 PF04317.12 EFC36770.1 - 0.13 11.2 0.2 0.19 10.6 0.2 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 Actin PF00022.19 EFC36771.1 - 3.9e-53 180.5 0.0 2.7e-51 174.5 0.0 2.0 1 1 0 1 1 1 1 Actin RL11D PF11088.8 EFC36771.1 - 0.11 12.7 0.2 59 4.0 0.0 3.1 3 0 0 3 3 3 0 Glycoprotein encoding membrane proteins RL5A and RL6 adh_short PF00106.25 EFC36773.1 - 2.4e-38 131.6 0.0 3.2e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC36773.1 - 8.3e-25 87.7 0.0 9.8e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 EFC36773.1 - 2.7e-05 23.5 0.0 4.2e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Methyltransf_31 PF13847.6 EFC36773.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC36773.1 - 0.0037 17.9 0.0 0.0078 16.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 EFC36773.1 - 0.004 16.7 0.0 0.0062 16.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EFC36773.1 - 0.0048 16.8 0.0 0.019 14.9 0.0 1.9 3 0 0 3 3 3 1 KR domain 3Beta_HSD PF01073.19 EFC36773.1 - 0.02 13.9 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_11 PF08241.12 EFC36773.1 - 0.04 14.6 0.0 0.099 13.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFC36773.1 - 0.09 12.1 0.0 0.26 10.6 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Zn_clus PF00172.18 EFC36774.1 - 0.00012 22.1 13.5 0.00019 21.5 13.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tubulin PF00091.25 EFC36775.1 - 6.5e-70 235.4 0.0 1.2e-69 234.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC36775.1 - 3.6e-41 140.3 0.1 5.5e-41 139.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC36775.1 - 3.6e-05 24.1 0.0 9.8e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EFC36775.1 - 0.00063 19.0 0.0 0.0029 16.9 0.0 1.9 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EFC36775.1 - 0.0011 18.6 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain ubiquitin PF00240.23 EFC36776.1 - 7.4e-63 208.2 5.9 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC36776.1 - 2.9e-30 103.9 7.5 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC36776.1 - 5.5e-09 36.4 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC36776.1 - 1.3e-08 34.6 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC36776.1 - 1.4e-08 34.8 0.4 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC36776.1 - 5.8e-07 29.8 1.6 0.025 14.9 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC36776.1 - 1.2e-06 29.0 0.1 0.015 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC36776.1 - 9e-05 22.4 6.5 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain Coagulin PF02035.15 EFC36776.1 - 0.043 13.7 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC36776.1 - 0.05 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC36776.1 - 0.072 13.5 1.0 0.84 10.0 0.2 2.5 2 1 0 3 3 3 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC36776.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC36776.1 - 0.14 12.3 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC36776.1 - 0.22 11.7 1.5 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain BTB_2 PF02214.22 EFC36777.1 - 1.9e-16 60.2 6.1 2.1e-09 37.6 0.1 4.1 4 0 0 4 4 4 2 BTB/POZ domain BTB PF00651.31 EFC36777.1 - 0.11 12.8 0.4 0.39 11.0 0.1 2.2 2 0 0 2 2 2 0 BTB/POZ domain Complex1_LYR PF05347.15 EFC36777.1 - 1.6 8.9 7.1 0.32 11.1 1.8 2.7 2 0 0 2 2 2 0 Complex 1 protein (LYR family) CutA1 PF03091.15 EFC36778.1 - 1.2e-33 114.9 0.3 1.2e-33 114.9 0.3 1.4 2 0 0 2 2 2 1 CutA1 divalent ion tolerance protein TFIIS_C PF01096.18 EFC36778.1 - 8.3e-19 67.2 8.6 2.1e-18 65.8 8.6 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Pox_vIL-18BP PF05566.12 EFC36778.1 - 0.05 13.8 0.5 0.28 11.4 0.1 2.2 2 1 0 2 2 2 0 Orthopoxvirus interleukin 18 binding protein TF_Zn_Ribbon PF08271.12 EFC36778.1 - 0.077 12.5 2.1 0.2 11.2 2.1 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding PSCyt3 PF07627.11 EFC36778.1 - 0.09 13.1 0.3 1.2 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) Elf1 PF05129.13 EFC36778.1 - 0.21 11.7 5.6 0.073 13.1 2.9 1.7 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like IBR PF01485.21 EFC36778.1 - 0.46 10.8 6.6 0.41 10.9 3.6 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain EndoU_bacteria PF14436.6 EFC36779.1 - 0.048 14.0 0.3 0.11 12.8 0.3 1.6 1 0 0 1 1 1 0 Bacterial EndoU nuclease RNase_H PF00075.24 EFC36780.1 - 7e-14 52.2 0.0 2.3e-13 50.5 0.0 2.0 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 EFC36780.1 - 1.4e-05 24.9 0.8 1.4e-05 24.9 0.8 2.5 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase RVT_3 PF13456.6 EFC36780.1 - 0.014 15.2 0.0 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase-like Exo_endo_phos PF03372.23 EFC36780.1 - 0.062 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Activator_LAG-3 PF11498.8 EFC36780.1 - 0.15 11.0 0.0 0.31 9.9 0.0 1.4 1 0 0 1 1 1 0 Transcriptional activator LAG-3 CPBP PF02517.16 EFC36781.1 - 0.015 15.7 1.5 0.02 15.3 0.1 1.9 2 0 0 2 2 2 0 CPBP intramembrane metalloprotease ThrE PF06738.12 EFC36781.1 - 0.079 12.3 0.2 0.2 11.0 0.0 1.7 2 0 0 2 2 2 0 Putative threonine/serine exporter Zn_clus PF00172.18 EFC36782.1 - 2.1e-08 34.1 9.7 3.3e-08 33.5 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3198 PF11433.8 EFC36783.1 - 0.0054 16.6 0.4 0.011 15.6 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3198) CRAL_TRIO PF00650.20 EFC36784.1 - 2.6e-17 63.0 0.9 3.9e-17 62.4 0.9 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain RNA_lig_T4_1 PF09511.10 EFC36785.1 - 0.17 11.7 0.0 0.38 10.6 0.0 1.4 1 1 0 1 1 1 0 RNA ligase F-box_5 PF18511.1 EFC36786.1 - 0.00036 20.1 0.5 0.00074 19.0 0.5 1.6 1 0 0 1 1 1 1 F-box CDP-OH_P_transf PF01066.21 EFC36787.1 - 5.6e-06 27.0 0.6 5.6e-06 27.0 0.6 2.0 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase PhyH PF05721.13 EFC36787.1 - 0.00045 20.6 0.0 0.00066 20.0 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF4418 PF14387.6 EFC36787.1 - 0.024 14.8 0.3 0.024 14.8 0.3 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4418) Copine PF07002.16 EFC36788.1 - 1.1e-25 90.4 0.7 8.3e-25 87.5 0.5 2.5 2 1 0 2 2 2 1 Copine C2 PF00168.30 EFC36788.1 - 1.2e-11 44.8 0.0 2.9e-11 43.5 0.0 1.6 1 0 0 1 1 1 1 C2 domain E1-E2_ATPase PF00122.20 EFC36789.1 - 6.3e-27 94.3 0.6 6.3e-27 94.3 0.6 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFC36789.1 - 2.2e-12 47.1 0.1 2.2e-12 47.1 0.1 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFC36789.1 - 1.4e-11 45.1 1.0 6.3e-10 39.7 1.0 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC36789.1 - 4e-08 33.3 7.0 1.8e-05 24.6 0.8 3.7 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFC36789.1 - 1.9e-07 30.7 0.0 7.6e-07 28.7 0.0 2.1 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFC36789.1 - 0.0077 16.3 0.0 0.019 15.0 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) DUF2079 PF09852.9 EFC36789.1 - 0.82 8.4 4.1 2 7.2 4.1 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) DUF2628 PF10947.8 EFC36789.1 - 0.84 10.0 2.9 0.5 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) DUF3671 PF12420.8 EFC36789.1 - 1.3 9.1 6.9 1.1 9.4 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function VCX_VCY PF15231.6 EFC36791.1 - 0.07 13.8 0.5 0.23 12.2 0.5 1.8 1 0 0 1 1 1 0 Variable charge X/Y family FKS1_dom1 PF14288.6 EFC36791.1 - 0.24 11.7 3.3 1 9.7 0.4 2.9 2 1 1 3 3 3 0 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF2262 PF10020.9 EFC36792.1 - 2.9e-17 63.4 0.8 3.6e-17 63.1 0.8 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2262) DUF4116 PF13475.6 EFC36793.1 - 1.6e-25 88.6 6.0 8.3e-12 44.7 0.0 6.3 6 2 0 6 6 6 3 Domain of unknown function (DUF4116) IlvC PF01450.19 EFC36793.1 - 0.14 12.4 0.4 2 8.7 0.1 2.6 2 1 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain RCC1 PF00415.18 EFC36794.1 - 5.7e-08 33.3 0.0 8.7e-06 26.3 0.0 3.2 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC36794.1 - 4.2e-07 30.2 8.5 0.00094 19.4 1.1 4.1 3 2 0 3 3 3 2 BTB/POZ domain RCC1_2 PF13540.6 EFC36794.1 - 1.7e-06 27.7 3.7 0.14 12.0 0.0 4.4 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 EFC36795.1 - 7.4e-13 48.3 0.1 2.8e-06 27.2 0.0 3.6 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC36795.1 - 1.3e-12 47.7 0.1 6e-05 23.2 0.0 4.6 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC36795.1 - 2e-09 37.4 0.1 0.011 15.9 0.0 4.7 4 1 1 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EFC36795.1 - 3e-08 33.5 1.3 0.0049 16.8 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 EFC36795.1 - 6.1e-06 26.0 0.2 0.42 10.7 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFC36795.1 - 3.5e-05 23.3 0.8 0.74 9.4 0.2 4.3 4 1 0 4 4 4 1 Kelch motif PAP2 PF01569.21 EFC36796.1 - 2.1e-10 40.5 0.1 4.5e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 PAP2 superfamily VCPO_N PF17897.1 EFC36796.1 - 0.011 15.5 0.0 0.066 13.0 0.0 2.1 2 0 0 2 2 2 0 Vanadium chloroperoxidase N-terminal domain BTB_2 PF02214.22 EFC36797.1 - 1.2e-17 64.0 2.9 1.4e-09 38.2 0.1 4.2 3 0 0 3 3 3 2 BTB/POZ domain DUF241 PF03087.14 EFC36797.1 - 5.2 6.8 9.4 1.2 9.0 0.8 2.7 2 0 0 2 2 2 0 Arabidopsis protein of unknown function DUF5089 PF17002.5 EFC36799.1 - 0.036 14.0 2.7 0.34 10.8 3.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) DUF2457 PF10446.9 EFC36799.1 - 0.44 9.6 10.0 0.63 9.1 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PTPRCAP PF15713.5 EFC36799.1 - 1.1 9.6 4.8 1.9 8.8 4.8 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Pkinase PF00069.25 EFC36801.1 - 8.5e-29 100.7 4.4 2.3e-13 50.1 1.7 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36801.1 - 2.7e-14 53.1 3.9 9.4e-08 31.7 0.3 3.8 3 1 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC36801.1 - 0.0028 16.5 0.2 0.0053 15.6 0.2 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC36801.1 - 0.012 14.9 0.3 0.1 11.9 0.0 2.3 2 1 0 2 2 2 0 Kinase-like Band_7 PF01145.25 EFC36802.1 - 2e-21 76.8 0.8 4.4e-21 75.7 0.8 1.5 1 0 0 1 1 1 1 SPFH domain / Band 7 family TRAM_LAG1_CLN8 PF03798.16 EFC36803.1 - 6.1e-20 71.8 23.0 9.3e-20 71.2 23.0 1.3 1 0 0 1 1 1 1 TLC domain PHD PF00628.29 EFC36804.1 - 3.5e-15 55.6 27.5 1.1e-09 38.0 10.2 2.6 1 1 1 2 2 2 2 PHD-finger C1_1 PF00130.22 EFC36804.1 - 0.0011 18.7 4.9 0.0011 18.7 4.9 3.6 1 1 3 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_2 PF13831.6 EFC36804.1 - 0.0049 16.4 8.0 0.0049 16.4 8.0 3.4 3 1 0 3 3 3 2 PHD-finger DUF2318 PF10080.9 EFC36804.1 - 0.038 14.1 26.9 0.31 11.2 2.6 3.9 2 2 1 3 3 3 0 Predicted membrane protein (DUF2318) Ndc1_Nup PF09531.10 EFC36804.1 - 1.1 7.9 4.7 1.5 7.5 4.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SNARE PF05739.19 EFC36805.1 - 1.9e-06 27.8 0.7 4.1e-06 26.7 0.7 1.6 1 0 0 1 1 1 1 SNARE domain V-SNARE_C PF12352.8 EFC36805.1 - 1.9e-05 24.8 1.4 4.7e-05 23.6 1.4 1.7 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFC36805.1 - 0.0057 16.5 0.4 0.0057 16.5 0.4 2.6 1 1 2 3 3 3 1 Sec20 Synaptobrevin PF00957.21 EFC36805.1 - 0.0063 16.3 2.6 0.0063 16.3 2.6 2.4 2 1 1 3 3 3 1 Synaptobrevin OAD_gamma PF04277.13 EFC36805.1 - 0.085 13.5 9.3 1.3 9.7 0.0 3.0 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF4834 PF16118.5 EFC36805.1 - 0.12 13.4 10.8 0.58 11.2 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) T2SSF PF00482.23 EFC36805.1 - 0.15 12.0 0.5 0.94 9.4 0.3 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F HemY_N PF07219.13 EFC36805.1 - 0.15 12.2 0.0 0.45 10.7 0.0 1.8 1 0 0 1 1 1 0 HemY protein N-terminus DUF2371 PF10177.9 EFC36805.1 - 0.16 12.2 0.0 0.16 12.2 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) G0-G1_switch_2 PF15103.6 EFC36805.1 - 0.83 10.1 0.0 0.83 10.1 0.0 3.1 2 1 0 2 2 1 0 G0/G1 switch protein 2 MCPsignal PF00015.21 EFC36805.1 - 0.98 9.2 9.8 0.15 11.8 1.9 2.4 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Zip PF02535.22 EFC36805.1 - 1.8 7.7 0.0 1.8 7.7 0.0 2.1 1 1 1 2 2 2 0 ZIP Zinc transporter Vpu PF00558.19 EFC36805.1 - 3.3 7.6 14.1 0.6 9.9 1.1 3.8 4 0 0 4 4 4 0 Vpu protein Vps51 PF08700.11 EFC36806.1 - 8.3e-07 29.0 1.7 8.3e-07 29.0 1.7 3.8 4 0 0 4 4 4 1 Vps51/Vps67 Stork_head PF10264.9 EFC36806.1 - 0.17 12.1 0.9 3.6 7.8 0.1 3.1 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain DUF3510 PF12022.8 EFC36806.1 - 0.65 10.4 8.6 0.59 10.5 0.2 3.8 2 1 1 4 4 4 0 Domain of unknown function (DUF3510) Phosphoesterase PF04185.14 EFC36807.1 - 2e-75 254.2 7.4 2.5e-75 253.9 7.4 1.1 1 0 0 1 1 1 1 Phosphoesterase family F-box PF00646.33 EFC36808.1 - 1.7e-05 24.6 0.0 4.2e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EFC36808.1 - 0.0099 16.3 2.1 47 4.6 0.6 4.7 3 1 1 4 4 4 1 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC36808.1 - 0.062 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 F-box-like Methyltransf_25 PF13649.6 EFC36809.1 - 6.9e-16 58.7 0.0 2.6e-15 56.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC36809.1 - 6.4e-15 55.6 0.0 1.6e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC36809.1 - 1.1e-12 47.8 0.2 9.8e-12 44.7 0.2 2.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC36809.1 - 1.9e-10 40.8 0.0 4.5e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC36809.1 - 4.6e-10 39.5 0.8 2.8e-09 37.0 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC36809.1 - 1.6e-08 35.2 0.0 1.6e-08 35.2 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain SDA1 PF05285.12 EFC36810.1 - 0.53 9.7 9.0 0.68 9.3 9.0 1.2 1 0 0 1 1 1 0 SDA1 Lipase_3 PF01764.25 EFC36811.1 - 2.6e-20 72.7 0.0 5.2e-20 71.8 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EFC36811.1 - 0.00024 20.7 0.1 0.00035 20.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PUF PF00806.19 EFC36812.1 - 1.1e-66 216.9 15.7 5.6e-08 32.1 0.0 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 EFC36812.1 - 2.3e-05 24.8 3.0 0.2 12.0 0.6 4.2 2 1 1 4 4 4 2 CPL (NUC119) domain Tk-SP_N-pro PF18237.1 EFC36812.1 - 0.019 15.0 0.3 0.073 13.1 0.3 2.0 1 0 0 1 1 1 0 Tk-SP N-propeptide domain SAC3 PF12209.8 EFC36812.1 - 0.021 15.0 3.6 0.95 9.7 0.4 4.0 2 1 1 3 3 3 0 Leucine permease transcriptional regulator helical domain PNPase PF03726.14 EFC36812.1 - 0.086 13.3 0.6 0.99 9.9 0.2 2.8 2 1 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Peptidase_C1 PF00112.23 EFC36814.1 - 8.8e-47 160.0 6.4 8.6e-45 153.5 1.9 2.4 3 0 0 3 3 3 2 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC36814.1 - 0.00024 20.9 0.4 0.00085 19.2 0.4 1.9 2 0 0 2 2 2 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EFC36814.1 - 0.25 10.1 0.0 0.25 10.1 0.0 3.2 4 0 0 4 4 4 0 Peptidase C1-like family Patatin PF01734.22 EFC36816.1 - 1.7e-22 80.6 0.3 3.7e-22 79.5 0.3 1.6 1 1 0 1 1 1 1 Patatin-like phospholipase UNC-79 PF14776.6 EFC36817.1 - 0.0015 17.4 0.0 0.0028 16.5 0.0 1.4 1 0 0 1 1 1 1 Cation-channel complex subunit UNC-79 EAF PF09816.9 EFC36818.1 - 8.5e-15 55.0 0.7 8.5e-15 55.0 0.7 1.7 2 0 0 2 2 2 1 RNA polymerase II transcription elongation factor Cwf_Cwc_15 PF04889.12 EFC36818.1 - 0.51 10.0 7.6 0.75 9.5 7.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Cofilin_ADF PF00241.20 EFC36819.1 - 2.7e-24 85.3 0.6 3.1e-24 85.1 0.6 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein LRR_4 PF12799.7 EFC36820.1 - 5.7e-14 52.0 57.9 0.00012 22.4 4.6 9.6 3 3 9 12 12 12 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36820.1 - 6.9e-13 48.2 37.5 3.7e-06 26.6 3.2 8.5 10 0 0 10 10 10 5 Leucine rich repeat LRR_6 PF13516.6 EFC36820.1 - 2.7e-12 45.7 40.3 0.11 12.6 0.0 10.8 11 0 0 11 11 11 6 Leucine Rich repeat LRR_9 PF14580.6 EFC36820.1 - 0.038 13.5 9.6 3.7 7.0 0.2 4.0 3 1 1 4 4 4 0 Leucine-rich repeat LRR_1 PF00560.33 EFC36820.1 - 4.6 8.2 39.8 2.9 8.8 0.1 10.6 10 2 0 10 10 10 0 Leucine Rich Repeat PSS PF03034.15 EFC36821.1 - 1.2e-112 376.1 12.9 3e-112 374.8 12.9 1.7 1 0 0 1 1 1 1 Phosphatidyl serine synthase E1-E2_ATPase PF00122.20 EFC36821.1 - 0.057 12.9 0.4 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 E1-E2 ATPase DUF2070 PF09843.9 EFC36821.1 - 5.3 5.2 8.9 2.4 6.4 4.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF826 PF05696.11 EFC36822.1 - 0.034 14.2 0.1 0.12 12.5 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF826) IF2_N PF04760.15 EFC36822.1 - 0.079 12.8 3.8 2.5 8.0 0.0 4.2 4 0 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region CLP1_P PF16575.5 EFC36822.1 - 0.081 12.7 3.1 0.05 13.4 0.5 1.9 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ARID PF01388.21 EFC36823.1 - 0.00038 21.1 0.0 0.0024 18.5 0.0 2.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain IL8 PF00048.20 EFC36824.1 - 0.053 13.7 0.1 0.12 12.5 0.1 1.6 1 0 0 1 1 1 0 Small cytokines (intecrine/chemokine), interleukin-8 like MACPF PF01823.19 EFC36825.1 - 8.4e-08 32.6 0.1 1.9e-07 31.4 0.1 1.6 1 1 0 1 1 1 1 MAC/Perforin domain PerB PF06590.11 EFC36825.1 - 0.13 12.8 0.1 0.39 11.2 0.1 1.8 1 0 0 1 1 1 0 PerB protein ADH_N PF08240.12 EFC36826.1 - 6.2e-10 38.9 0.2 1.5e-09 37.7 0.1 1.6 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFC36826.1 - 1.1e-09 39.4 0.0 2.7e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC36826.1 - 2e-06 27.8 0.0 4.1e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EFC36826.1 - 0.0011 18.9 0.0 0.0054 16.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2855) Pkinase PF00069.25 EFC36827.1 - 1.2e-31 110.1 0.9 1.9e-31 109.4 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36827.1 - 3.8e-18 65.7 0.1 7.7e-18 64.7 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC36827.1 - 7.1e-17 61.8 0.6 1.8e-08 34.8 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC36827.1 - 1.2e-13 50.9 1.6 0.00077 19.7 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC36827.1 - 1.8e-13 49.3 2.5 0.046 14.3 0.0 6.5 7 0 0 7 7 6 3 Ankyrin repeat Ank_4 PF13637.6 EFC36827.1 - 4.6e-08 33.4 0.2 0.078 13.6 0.0 4.1 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC36827.1 - 6.6e-06 26.3 0.0 0.94 10.0 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Pkinase_fungal PF17667.1 EFC36827.1 - 0.00081 18.3 0.0 0.0017 17.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC36827.1 - 0.0021 17.5 0.1 0.0064 15.9 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC36827.1 - 0.013 14.8 0.0 0.032 13.6 0.0 1.6 1 0 0 1 1 1 0 Kinase-like DHBP_synthase PF00926.19 EFC36827.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 3,4-dihydroxy-2-butanone 4-phosphate synthase THF_DHG_CYH_C PF02882.19 EFC36828.1 - 1.5e-47 160.9 0.5 2.3e-47 160.3 0.5 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EFC36828.1 - 6.7e-38 129.5 0.8 1.3e-37 128.6 0.8 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AdoHcyase_NAD PF00670.21 EFC36828.1 - 0.023 14.8 0.1 0.047 13.7 0.1 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Pkinase PF00069.25 EFC36829.1 - 6e-60 202.8 4.4 3.8e-34 118.2 0.7 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36829.1 - 3.1e-41 141.4 1.9 1.8e-27 96.3 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC36829.1 - 0.0035 16.2 0.0 0.0086 14.9 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFC36829.1 - 0.032 13.9 0.0 0.078 12.6 0.0 1.6 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Peptidase_C12 PF01088.21 EFC36832.1 - 7.6e-50 169.6 0.2 8.6e-50 169.4 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 LRR_6 PF13516.6 EFC36834.1 - 1.3e-15 56.0 7.2 0.0031 17.5 0.0 6.3 6 0 0 6 6 6 5 Leucine Rich repeat LRR_8 PF13855.6 EFC36834.1 - 2.1e-13 49.8 16.2 4.3e-08 32.8 0.2 3.5 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC36834.1 - 2.6e-11 43.6 10.8 4.3e-05 23.8 0.1 4.6 2 1 1 4 4 4 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC36834.1 - 2.7e-05 24.0 0.7 5.8e-05 22.9 0.7 1.6 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC36834.1 - 6.6e-05 22.9 2.3 1.2 10.0 0.1 5.7 6 0 0 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC36834.1 - 0.005 16.4 3.2 0.007 15.9 0.4 2.1 1 1 1 2 2 2 1 Leucine-rich repeat F-box PF00646.33 EFC36834.1 - 0.02 14.7 0.2 0.05 13.5 0.2 1.7 1 0 0 1 1 1 0 F-box domain Ras PF00071.22 EFC36835.1 - 1.3e-21 76.9 0.1 2e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36835.1 - 2.5e-18 66.4 0.0 4.4e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC36835.1 - 7.9e-07 28.8 1.1 3.4e-06 26.8 0.3 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC36835.1 - 1.6e-06 27.9 0.6 1.6e-06 27.9 0.6 2.1 3 0 0 3 3 3 1 F-box-like Arf PF00025.21 EFC36835.1 - 1.4e-05 24.6 0.0 2.2e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC36835.1 - 0.00037 20.6 0.1 0.00067 19.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC36835.1 - 0.0029 17.0 0.1 0.0047 16.3 0.1 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region TPR_1 PF00515.28 EFC36837.1 - 1.9e-12 46.5 17.8 1.5e-06 27.8 0.2 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC36837.1 - 1.1e-07 31.4 15.7 0.0004 20.0 0.7 4.3 4 1 1 5 5 5 2 TPR repeat TPR_2 PF07719.17 EFC36837.1 - 5.4e-07 29.2 14.8 0.00015 21.6 0.1 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC36837.1 - 6.2e-07 29.1 13.6 9.3e-05 22.4 0.9 4.8 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC36837.1 - 5.4e-06 26.6 3.6 0.00019 21.7 0.4 3.3 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC36837.1 - 7.9e-06 25.5 1.1 0.00084 19.2 0.1 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 EFC36837.1 - 3.7e-05 23.7 4.4 0.0027 17.7 1.1 3.1 2 1 1 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EFC36837.1 - 0.00026 21.6 0.2 0.67 10.9 0.0 3.3 1 1 3 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC36837.1 - 0.00056 20.1 3.9 0.94 10.0 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC36837.1 - 0.0012 18.7 0.7 2.6 8.0 0.0 3.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC36837.1 - 0.0075 16.8 2.1 0.19 12.2 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat MapZ_EC1 PF18041.1 EFC36837.1 - 0.046 13.9 0.6 0.046 13.9 0.6 2.3 2 0 0 2 2 2 0 MapZ extracellular domain 1 MRP-S34 PF16053.5 EFC36838.1 - 9e-09 35.1 0.1 1.1e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S34 Mto2_bdg PF12808.7 EFC36840.1 - 0.59 10.5 8.2 2 8.8 0.5 2.6 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region GIT1_C PF12205.8 EFC36840.1 - 4 7.6 9.1 1.5 9.0 3.3 2.8 2 1 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term TT1725 PF18324.1 EFC36840.1 - 5.2 7.2 7.4 27 4.9 0.9 3.7 4 0 0 4 4 4 0 Hypothetical protein TT1725 NHL PF01436.21 EFC36841.1 - 3.3e-10 39.5 0.0 0.00026 20.9 0.0 3.7 3 0 0 3 3 3 2 NHL repeat SGL PF08450.12 EFC36841.1 - 9.2e-05 22.1 0.5 1.4 8.5 0.1 3.2 2 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region PQQ PF01011.21 EFC36841.1 - 0.0054 16.6 0.1 4 7.6 0.0 3.0 2 0 0 2 2 2 2 PQQ enzyme repeat Phytase-like PF13449.6 EFC36841.1 - 0.0057 16.6 0.0 5.9 6.8 0.0 3.0 2 1 0 3 3 3 1 Esterase-like activity of phytase Arylesterase PF01731.20 EFC36841.1 - 0.022 15.0 0.7 0.56 10.5 0.1 2.6 2 1 0 2 2 2 0 Arylesterase Abhydrolase_1 PF00561.20 EFC36842.1 - 2.5e-08 33.9 0.0 4.4e-08 33.1 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC36842.1 - 0.00064 19.1 0.0 0.001 18.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 zinc_ribbon_13 PF09855.9 EFC36844.1 - 3.2e-17 62.4 3.1 5.1e-17 61.8 3.1 1.3 1 0 0 1 1 1 1 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) RhoGEF PF00621.20 EFC36844.1 - 0.02 15.1 1.0 0.024 14.9 1.0 1.1 1 0 0 1 1 1 0 RhoGEF domain YpjP PF14005.6 EFC36844.1 - 0.075 13.1 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 YpjP-like protein RNA_POL_M_15KD PF02150.16 EFC36844.1 - 0.66 9.9 4.1 9.7 6.2 0.4 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit DUF4116 PF13475.6 EFC36845.1 - 2.9e-64 212.6 36.5 4.8e-13 48.6 0.1 8.8 2 2 4 9 9 9 9 Domain of unknown function (DUF4116) Exo_endo_phos_2 PF14529.6 EFC36846.1 - 1.5e-05 24.8 1.4 7e-05 22.7 0.8 2.6 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EFC36846.1 - 0.0088 15.6 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Alkyl_sulf_C PF14864.6 EFC36846.1 - 0.025 14.9 2.4 0.051 13.8 1.0 2.2 2 0 0 2 2 2 0 Alkyl sulfatase C-terminal DRTGG PF07085.12 EFC36846.1 - 0.053 13.3 0.0 0.19 11.5 0.0 2.0 1 0 0 1 1 1 0 DRTGG domain FlaC_arch PF05377.11 EFC36846.1 - 0.13 12.7 1.2 0.95 9.9 0.3 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 EFC36846.1 - 0.34 11.2 16.5 5.6 7.3 0.5 3.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Trypsin_2 PF13365.6 EFC36849.1 - 0.00043 21.2 0.0 0.0012 19.7 0.0 1.7 1 1 1 2 2 2 1 Trypsin-like peptidase domain Yip1 PF04893.17 EFC36851.1 - 4.4e-13 49.3 3.9 6.4e-13 48.8 3.9 1.2 1 0 0 1 1 1 1 Yip1 domain Histone PF00125.24 EFC36852.1 - 2.3e-50 170.3 4.7 2.6e-50 170.2 4.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 EFC36852.1 - 1.7e-05 25.4 0.8 1.9e-05 25.3 0.8 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EFC36852.1 - 7.9e-05 22.7 0.3 7.9e-05 22.7 0.3 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFC36852.1 - 0.0003 21.1 0.1 0.00046 20.5 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFC36852.1 - 0.012 15.9 0.6 0.023 14.9 0.1 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFC36852.1 - 0.11 12.5 0.9 0.15 12.1 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit C2 PF00168.30 EFC36853.1 - 4.9e-18 65.3 0.1 1.1e-17 64.2 0.1 1.6 1 0 0 1 1 1 1 C2 domain YvfG PF09628.10 EFC36854.1 - 0.39 11.1 2.6 0.32 11.4 0.7 1.8 2 0 0 2 2 2 0 YvfG protein D123 PF07065.14 EFC36856.1 - 4.2e-22 78.7 0.6 2.8e-09 36.6 0.2 3.3 2 2 1 3 3 3 3 D123 R2K_2 PF18299.1 EFC36856.1 - 9.6e-06 25.5 0.2 0.0089 15.9 0.1 2.8 1 1 1 2 2 2 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 EFC36856.1 - 0.00065 19.8 0.0 0.0033 17.5 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 Ras PF00071.22 EFC36857.1 - 1.4e-17 63.8 0.0 1.8e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36857.1 - 4e-08 33.5 0.1 5.5e-08 33.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC36857.1 - 4.4e-06 26.3 0.0 6.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Pkinase PF00069.25 EFC36858.1 - 1.7e-21 76.8 4.8 9.1e-21 74.4 1.6 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36858.1 - 2.1e-08 33.8 0.1 3.9e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC36858.1 - 0.062 13.2 0.0 0.15 12.0 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC36858.1 - 0.14 10.9 2.2 0.13 11.0 0.5 1.6 2 0 0 2 2 2 0 Fungal protein kinase EFG_IV PF03764.18 EFC36859.1 - 6.7e-23 80.8 0.0 2e-22 79.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU PF00009.27 EFC36859.1 - 9.7e-18 64.4 0.0 1.8e-17 63.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC36859.1 - 8e-09 35.6 0.0 2.1e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EFC36859.1 - 9.4e-07 28.8 0.0 2.4e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFC36859.1 - 1.1e-06 28.6 0.0 6.4e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Elongation factor G C-terminus Roc PF08477.13 EFC36859.1 - 8e-05 22.8 0.0 0.00016 21.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D2 PF03144.25 EFC36859.1 - 0.0066 16.8 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 EFC36859.1 - 0.012 15.3 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 Ras family DUF5461 PF17545.2 EFC36859.1 - 0.071 13.4 0.0 0.25 11.7 0.0 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5461) ABC_tran PF00005.27 EFC36859.1 - 0.077 13.5 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 ABC transporter RecG_N PF17190.4 EFC36859.1 - 0.084 13.6 0.8 3.4 8.5 0.0 2.9 2 0 0 2 2 2 0 RecG N-terminal helical domain AAA_22 PF13401.6 EFC36859.1 - 0.13 12.5 0.0 0.47 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain CBP_BcsR PF10945.8 EFC36859.1 - 0.17 11.4 0.0 0.48 9.9 0.0 1.7 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsR RsgA_GTPase PF03193.16 EFC36859.1 - 0.18 11.7 1.7 20 5.0 0.1 2.9 1 1 2 3 3 3 0 RsgA GTPase Notch PF00066.17 EFC36860.1 - 0.011 16.1 1.6 0.019 15.4 1.6 1.3 1 0 0 1 1 1 0 LNR domain Cys_rich_FGFR PF00839.17 EFC36860.1 - 0.12 12.5 1.3 0.27 11.4 1.3 1.5 1 0 0 1 1 1 0 Cysteine rich repeat DUF1445 PF07286.12 EFC36862.1 - 5.1e-59 198.3 0.2 6.9e-59 197.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) F-box-like PF12937.7 EFC36863.1 - 0.00017 21.4 2.3 0.00057 19.7 0.1 2.9 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EFC36863.1 - 0.00029 20.6 0.1 0.00086 19.1 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EFC36863.1 - 0.11 12.1 0.1 0.4 10.3 0.1 2.0 1 0 0 1 1 1 0 F-box DUF5641 PF18701.1 EFC36863.1 - 0.13 12.4 0.0 0.41 10.8 0.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5641) Auxin_repressed PF05564.12 EFC36864.1 - 0.033 14.9 0.4 0.033 14.9 0.4 2.2 1 1 0 2 2 2 0 Dormancy/auxin associated protein SR-25 PF10500.9 EFC36864.1 - 7.1 6.2 9.5 15 5.1 9.5 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1201 PF06716.11 EFC36866.1 - 0.053 13.5 0.1 0.053 13.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) p450 PF00067.22 EFC36867.1 - 1.4e-11 43.8 1.9 4.8e-07 28.9 0.3 3.2 3 0 0 3 3 3 3 Cytochrome P450 WD40 PF00400.32 EFC36868.1 - 1.8e-14 53.9 5.5 0.0022 18.8 0.3 6.1 5 1 0 5 5 5 3 WD domain, G-beta repeat RAB3GAP2_N PF14655.6 EFC36868.1 - 6.4e-07 29.0 1.2 1.5e-05 24.5 0.1 2.6 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus ANAPC4_WD40 PF12894.7 EFC36868.1 - 5.1e-05 23.5 0.0 0.0039 17.5 0.0 3.1 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFC36868.1 - 0.005 16.9 0.1 0.25 11.4 0.0 3.2 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region F-box-like PF12937.7 EFC36868.1 - 0.051 13.5 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 F-box-like RNA_pol_Rpb2_6 PF00562.28 EFC36869.1 - 1.7e-127 425.8 0.1 2.5e-127 425.2 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFC36869.1 - 1.2e-51 175.1 0.3 1.9e-51 174.5 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 EFC36869.1 - 2.5e-40 138.2 0.0 4.7e-40 137.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 EFC36869.1 - 3e-32 110.9 0.3 7.3e-32 109.6 0.3 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 EFC36869.1 - 3.8e-25 87.8 0.1 9.6e-25 86.6 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 EFC36869.1 - 5.7e-23 81.0 0.2 1.4e-22 79.7 0.2 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 EFC36869.1 - 4.7e-17 62.3 0.0 1.2e-16 60.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RasGAP_C PF03836.15 EFC36869.1 - 0.023 14.8 2.5 0.18 11.9 0.3 3.1 4 0 0 4 4 4 0 RasGAP C-terminus OrfB_Zn_ribbon PF07282.11 EFC36869.1 - 0.13 12.2 0.3 0.32 11.0 0.3 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain UL42 PF17638.2 EFC36870.1 - 0.11 12.5 4.9 0.063 13.3 0.7 2.5 2 0 0 2 2 2 0 HCMV UL42 F-box PF00646.33 EFC36871.1 - 0.0014 18.5 0.7 0.0075 16.1 0.1 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC36871.1 - 0.076 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 F-box-like LRR_6 PF13516.6 EFC36872.1 - 1.1e-18 65.7 45.4 0.0057 16.6 0.3 9.7 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC36872.1 - 6.5e-12 45.5 52.0 0.00022 21.5 1.3 6.7 1 1 7 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36872.1 - 1e-08 34.8 46.2 0.00043 20.0 3.2 6.9 2 1 4 6 6 6 5 Leucine rich repeat F-box-like PF12937.7 EFC36872.1 - 1.8e-05 24.5 0.4 6.2e-05 22.8 0.4 1.8 1 0 0 1 1 1 1 F-box-like LRR_9 PF14580.6 EFC36872.1 - 0.00015 21.3 13.4 0.22 11.0 0.2 3.6 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EFC36872.1 - 0.47 11.2 45.2 0.55 11.0 0.5 9.3 7 2 1 8 8 8 0 Leucine Rich Repeat TRAPP PF04051.16 EFC36873.1 - 2.4e-32 111.7 0.0 2.9e-32 111.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Alpha_Helical PF18489.1 EFC36873.1 - 0.13 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Alpha helical domain LtuB PF17455.2 EFC36874.1 - 0.065 13.9 0.3 0.065 13.9 0.3 3.0 3 1 1 4 4 4 0 Late transcription unit B Fzo_mitofusin PF04799.13 EFC36874.1 - 0.14 11.7 3.0 0.52 9.9 3.0 1.9 1 0 0 1 1 1 0 fzo-like conserved region Chi-conotoxin PF16981.5 EFC36874.1 - 0.67 10.2 2.4 2.2 8.6 2.4 1.9 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily FH2 PF02181.23 EFC36875.1 - 5.1e-71 239.8 15.0 5.1e-71 239.8 15.0 3.5 5 0 0 5 5 5 1 Formin Homology 2 Domain BLUF PF04940.12 EFC36875.1 - 4e-24 84.5 2.1 7.7e-24 83.6 0.0 2.7 2 0 0 2 2 2 1 Sensors of blue-light using FAD Exonuc_VII_S PF02609.16 EFC36875.1 - 0.0054 16.8 1.7 0.02 14.9 0.4 2.8 2 0 0 2 2 2 1 Exonuclease VII small subunit TolA_bind_tri PF16331.5 EFC36875.1 - 0.15 12.1 4.7 0.098 12.7 0.6 2.9 2 0 0 2 2 2 0 TolA binding protein trimerisation SRP9-21 PF05486.12 EFC36875.1 - 0.71 10.3 3.8 0.62 10.5 0.7 2.4 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) RGS PF00615.19 EFC36875.1 - 0.84 9.9 13.7 0.017 15.4 2.9 3.9 5 1 0 5 5 5 0 Regulator of G protein signaling domain DivIC PF04977.15 EFC36875.1 - 2.4 8.0 12.6 0.41 10.5 0.8 4.1 3 0 0 3 3 3 0 Septum formation initiator Cation_ATPase_C PF00689.21 EFC36876.1 - 9.9e-40 136.2 11.4 9.9e-40 136.2 11.4 2.5 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFC36876.1 - 8.8e-38 129.6 1.4 8.8e-38 129.6 1.4 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFC36876.1 - 1.3e-19 71.4 0.0 5.3e-19 69.3 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC36876.1 - 7.4e-16 58.0 0.1 2e-15 56.6 0.1 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC36876.1 - 3.1e-08 33.2 0.6 1.3e-07 31.1 0.0 2.5 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC36876.1 - 1.7e-05 24.7 0.2 0.0014 18.4 0.1 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase EI24 PF07264.11 EFC36876.1 - 0.021 15.1 4.5 15 5.8 6.5 2.7 2 1 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) ParBc_2 PF08857.11 EFC36878.1 - 4.7e-18 65.8 0.1 6.8e-18 65.3 0.1 1.2 1 0 0 1 1 1 1 Putative ParB-like nuclease Guanylate_cyc PF00211.20 EFC36880.1 - 2.2e-23 82.8 1.0 5e-23 81.7 0.3 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC36880.1 - 2.3e-06 27.6 5.6 2.3e-06 27.6 5.6 2.0 2 0 0 2 2 2 1 Cache domain DSPc PF00782.20 EFC36881.1 - 4e-22 78.4 0.7 1.6e-19 70.0 0.4 2.5 1 1 1 2 2 2 2 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EFC36881.1 - 2.2e-06 27.9 0.0 5.7e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFC36881.1 - 0.00015 21.9 0.0 0.00039 20.6 0.0 1.7 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFC36881.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC36881.1 - 0.029 13.9 0.1 0.06 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 EFC36881.1 - 0.033 13.8 0.4 0.15 11.7 0.2 2.1 1 1 1 2 2 2 0 Tyrosine phosphatase family FAD-oxidase_C PF02913.19 EFC36883.1 - 2.5e-37 128.9 0.0 3e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain BBE PF08031.12 EFC36883.1 - 0.025 14.7 0.2 0.054 13.6 0.0 1.7 2 0 0 2 2 2 0 Berberine and berberine like RGS PF00615.19 EFC36885.1 - 6.4e-05 23.2 1.6 0.00075 19.8 0.2 3.4 3 2 1 4 4 4 1 Regulator of G protein signaling domain DUF4116 PF13475.6 EFC36886.1 - 1.3e-07 31.2 0.2 0.0033 17.1 0.0 2.9 1 1 3 4 4 4 4 Domain of unknown function (DUF4116) KRTAP PF11759.8 EFC36886.1 - 0.03 14.9 56.7 1.8e+04 -18.4 56.7 3.2 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 EFC36886.1 - 1.4 9.0 53.9 1.8e+04 -18.5 53.9 3.1 1 1 0 1 1 1 0 Keratin type II head F-box_4 PF15966.5 EFC36888.1 - 0.016 15.1 0.9 0.031 14.2 0.9 1.6 1 1 0 1 1 1 0 F-box F-box-like PF12937.7 EFC36888.1 - 0.08 12.8 0.5 0.15 12.0 0.5 1.4 1 0 0 1 1 1 0 F-box-like SPRY PF00622.28 EFC36888.1 - 0.11 12.6 1.3 0.15 12.2 0.5 1.7 2 0 0 2 2 2 0 SPRY domain Abi_2 PF07751.11 EFC36888.1 - 0.24 11.6 6.5 0.078 13.2 2.9 1.9 1 1 1 2 2 2 0 Abi-like protein GtrA PF04138.14 EFC36889.1 - 3.8e-10 40.0 13.6 4.8e-10 39.7 13.6 1.1 1 0 0 1 1 1 1 GtrA-like protein DUF4271 PF14093.6 EFC36889.1 - 0.041 13.8 15.5 0.055 13.4 15.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) Phage_integrase PF00589.22 EFC36890.1 - 0.00015 21.6 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family HCMV_UL139 PF12507.8 EFC36891.1 - 0.13 12.6 1.7 0.27 11.6 0.1 2.3 3 0 0 3 3 3 0 Human Cytomegalovirus UL139 protein Macoilin PF09726.9 EFC36891.1 - 0.82 8.2 12.2 0.7 8.4 11.5 1.3 1 1 0 1 1 1 0 Macoilin family LRR_6 PF13516.6 EFC36892.1 - 2.5e-52 170.5 74.7 0.00029 20.6 0.2 16.1 16 0 0 16 16 16 13 Leucine Rich repeat LRR_8 PF13855.6 EFC36892.1 - 4.1e-47 157.8 59.3 1e-11 44.4 4.6 7.1 4 1 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC36892.1 - 1.7e-40 136.3 65.4 7.6e-07 29.4 0.5 10.0 3 1 6 10 10 10 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC36892.1 - 3.6e-13 48.1 49.3 1.6 9.5 0.2 14.1 14 2 0 14 14 14 7 Leucine Rich Repeat LRR_9 PF14580.6 EFC36892.1 - 4.3e-13 49.1 14.1 4.7e-06 26.2 0.1 4.7 1 1 3 5 5 5 5 Leucine-rich repeat LRR_5 PF13306.6 EFC36892.1 - 7e-09 35.7 0.2 0.0019 18.2 0.0 4.2 1 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) F-box-like PF12937.7 EFC36892.1 - 1.6e-08 34.3 0.0 3.4e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC36892.1 - 2.8e-05 23.9 0.0 6.7e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 F-box domain Peripla_BP_7 PF18610.1 EFC36892.1 - 1.4 9.1 7.6 18 5.6 0.1 4.6 4 1 1 5 5 5 0 Periplasmic binding protein domain Telomere_reg-2 PF10193.9 EFC36895.1 - 9.1e-37 125.8 7.9 1.2e-36 125.5 0.9 3.6 4 0 0 4 4 4 1 Telomere length regulation protein DUF3452 PF11934.8 EFC36895.1 - 0.26 10.8 4.7 0.18 11.4 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) Mur_ligase_M PF08245.12 EFC36896.1 - 1.1e-10 41.8 0.2 1.1e-09 38.6 0.0 2.5 2 1 0 2 2 2 1 Mur ligase middle domain DSPc PF00782.20 EFC36896.1 - 2.5 7.9 5.0 2.1 8.2 0.0 2.9 3 1 0 3 3 3 0 Dual specificity phosphatase, catalytic domain V_ATPase_I PF01496.19 EFC36897.1 - 1.2e-262 873.5 9.4 1.5e-262 873.3 9.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family EIIA-man PF03610.16 EFC36897.1 - 0.081 13.2 0.2 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 PTS system fructose IIA component Baculo_PEP_C PF04513.12 EFC36897.1 - 0.12 12.4 0.1 8.7 6.4 0.0 2.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 EFC36897.1 - 0.23 11.6 3.5 2.2 8.5 0.1 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family CLZ PF16526.5 EFC36897.1 - 0.48 10.8 4.4 8 6.9 0.1 3.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tup_N PF08581.10 EFC36897.1 - 0.56 10.6 3.9 2.1 8.7 1.2 2.9 2 1 0 2 2 2 0 Tup N-terminal TMF_TATA_bd PF12325.8 EFC36897.1 - 1.5 9.1 9.9 0.43 10.8 1.8 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.12 EFC36897.1 - 4 7.5 8.5 2.6 8.1 2.2 2.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein IQ PF00612.27 EFC36898.1 - 0.0011 18.5 0.4 0.085 12.7 0.0 3.3 3 0 0 3 3 3 1 IQ calmodulin-binding motif RGS PF00615.19 EFC36899.1 - 1.3e-06 28.6 2.3 4.6e-06 26.9 2.3 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 EFC36900.1 - 7.9e-11 42.3 0.3 1e-09 38.7 0.3 2.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain 2OG-FeII_Oxy_3 PF13640.6 EFC36901.1 - 6.4e-09 36.6 0.0 1.6e-08 35.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EFC36901.1 - 0.00013 22.3 0.0 0.00037 20.8 0.0 1.7 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase PhyH PF05721.13 EFC36901.1 - 0.028 14.7 0.0 0.16 12.2 0.0 2.1 1 1 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Putative_PNPOx PF01243.20 EFC36902.1 - 5.2e-14 52.2 0.0 7.3e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 EFC36902.1 - 3e-13 49.6 0.3 5.1e-13 48.9 0.3 1.4 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 EFC36902.1 - 1.5e-06 28.7 0.0 2.6e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Claudin_2 PF13903.6 EFC36903.1 - 0.0044 16.8 0.3 0.0057 16.4 0.3 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Neurensin PF14927.6 EFC36903.1 - 0.017 14.8 0.9 0.12 12.1 0.9 2.1 1 1 0 1 1 1 0 Neurensin L_HMGIC_fpl PF10242.9 EFC36903.1 - 0.039 14.2 0.3 0.052 13.7 0.3 1.1 1 0 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein DUF2207 PF09972.9 EFC36903.1 - 0.087 11.6 0.2 0.11 11.2 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EFC36903.1 - 0.093 12.8 3.7 0.14 12.2 3.7 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III TMEM119 PF15724.5 EFC36903.1 - 0.27 11.3 1.9 0.36 10.8 1.9 1.2 1 0 0 1 1 1 0 TMEM119 family DUF202 PF02656.15 EFC36903.1 - 0.41 11.1 7.1 1.6 9.2 7.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF202) Cadherin_C_2 PF16492.5 EFC36903.1 - 1.4 9.7 4.2 11 6.9 0.0 2.6 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal Phage_holin_3_6 PF07332.11 EFC36904.1 - 0.16 12.0 1.7 0.22 11.5 1.7 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4116 PF13475.6 EFC36905.1 - 5.1e-45 151.0 11.9 2.6e-11 43.1 0.2 5.6 2 1 2 5 5 5 5 Domain of unknown function (DUF4116) COMM_domain PF07258.14 EFC36906.1 - 5.6e-09 36.0 0.8 1.1e-08 35.0 0.8 1.6 1 0 0 1 1 1 1 COMM domain DUF4035 PF13227.6 EFC36906.1 - 0.0012 18.5 0.0 0.0062 16.2 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4035) DUF2369 PF10179.9 EFC36907.1 - 0.0016 18.8 0.1 0.13 12.6 0.0 2.7 3 0 0 3 3 3 2 Uncharacterised conserved protein (DUF2369) Acetyltransf_CG PF14542.6 EFC36910.1 - 3.2e-05 24.0 0.0 0.00029 20.9 0.0 2.4 3 0 0 3 3 3 1 GCN5-related N-acetyl-transferase Acetyltransf_7 PF13508.7 EFC36910.1 - 0.0029 18.0 0.2 0.015 15.7 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC36910.1 - 0.0037 17.3 0.0 0.13 12.4 0.0 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC36910.1 - 0.0062 16.8 0.1 0.016 15.5 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Arf PF00025.21 EFC36911.1 - 1.1e-43 148.7 0.3 1.3e-43 148.5 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC36911.1 - 1.5e-11 44.4 0.1 2.4e-11 43.7 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFC36911.1 - 1.6e-11 44.5 0.0 2.3e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC36911.1 - 3.4e-11 43.0 0.0 3.9e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFC36911.1 - 1.2e-10 41.1 0.0 1.5e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFC36911.1 - 1.5e-10 40.8 0.7 1.2e-06 28.0 0.1 2.6 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 EFC36911.1 - 8.9e-10 38.4 0.4 3e-08 33.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC36911.1 - 4.1e-08 32.9 0.0 5.4e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFC36911.1 - 6.5e-05 22.5 2.1 0.00034 20.2 2.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EFC36911.1 - 0.003 17.4 0.0 0.6 9.8 0.0 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein cobW PF02492.19 EFC36911.1 - 0.0056 16.3 0.4 2.6 7.6 0.1 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFC36911.1 - 0.02 14.8 1.0 3.9 7.4 0.1 2.3 1 1 0 2 2 2 0 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EFC36911.1 - 0.027 14.5 0.3 0.055 13.5 0.3 1.6 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EFC36911.1 - 0.028 14.5 0.0 3 7.9 0.1 2.2 1 1 1 2 2 2 0 Dynamin family NACHT PF05729.12 EFC36911.1 - 0.04 13.8 0.1 4.4 7.2 0.1 2.1 2 0 0 2 2 2 0 NACHT domain AAA_7 PF12775.7 EFC36911.1 - 0.041 13.4 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EFC36911.1 - 0.068 12.9 0.2 0.37 10.5 0.2 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EFC36911.1 - 0.13 12.7 0.1 0.18 12.3 0.1 1.4 1 1 0 1 1 1 0 ABC transporter NOG1 PF06858.14 EFC36911.1 - 0.19 11.5 1.6 1.2 9.0 0.8 2.5 2 1 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) AAA_33 PF13671.6 EFC36911.1 - 0.2 11.8 0.1 1.1 9.4 0.0 1.9 1 1 0 2 2 2 0 AAA domain DUF676 PF05057.14 EFC36912.1 - 1.9e-36 125.6 0.0 3e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFC36912.1 - 0.0013 18.5 0.2 0.003 17.3 0.2 1.5 1 1 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EFC36912.1 - 0.0066 16.3 0.0 0.0099 15.7 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EFC36912.1 - 0.0068 16.3 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) STAS PF01740.21 EFC36912.1 - 0.011 15.4 0.1 0.024 14.3 0.1 1.5 1 0 0 1 1 1 0 STAS domain PARG_cat PF05028.14 EFC36913.1 - 1.7e-90 303.8 0.0 2.4e-90 303.3 0.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) SNF2_N PF00176.23 EFC36914.1 - 8.5e-69 231.9 0.1 2.6e-68 230.3 0.1 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC36914.1 - 3.2e-19 69.3 1.0 2.3e-18 66.5 0.0 2.9 3 1 0 3 3 3 1 Helicase conserved C-terminal domain Mu-like_Pro PF10123.9 EFC36914.1 - 0.31 10.6 6.3 0.81 9.2 5.7 1.9 2 0 0 2 2 2 0 Mu-like prophage I protein Exonuc_VII_L PF02601.15 EFC36914.1 - 0.99 8.9 8.0 2.7 7.5 8.0 1.8 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ran_BP1 PF00638.18 EFC36915.1 - 3.5e-18 66.0 0.3 8.1e-18 64.9 0.3 1.6 1 0 0 1 1 1 1 RanBP1 domain DUF2076 PF09849.9 EFC36915.1 - 0.00027 21.1 1.3 0.00027 21.1 1.3 2.1 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2076) bZIP_1 PF00170.21 EFC36915.1 - 0.029 14.4 2.0 0.079 13.1 2.0 1.7 1 0 0 1 1 1 0 bZIP transcription factor SKA1 PF07160.12 EFC36915.1 - 0.072 12.9 4.0 0.14 12.0 4.0 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 SWIM PF04434.17 EFC36916.1 - 1.1e-06 28.2 0.1 1.1e-06 28.2 0.1 2.0 2 0 0 2 2 2 1 SWIM zinc finger zf-RING_2 PF13639.6 EFC36916.1 - 0.00014 22.1 12.3 0.00014 22.1 12.3 2.2 3 0 0 3 3 3 1 Ring finger domain Rho_N PF07498.12 EFC36916.1 - 0.00048 20.0 0.0 0.00094 19.1 0.0 1.5 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain SAP PF02037.27 EFC36916.1 - 0.034 13.9 0.6 2.7 7.8 0.0 2.6 2 0 0 2 2 2 0 SAP domain EcKinase PF02958.20 EFC36916.1 - 0.084 12.2 2.9 0.13 11.6 1.5 2.0 1 1 1 2 2 2 0 Ecdysteroid kinase RINGv PF12906.7 EFC36916.1 - 0.2 11.8 11.6 0.64 10.2 11.6 1.9 1 0 0 1 1 1 0 RING-variant domain DUF5318 PF17249.2 EFC36916.1 - 0.67 9.7 3.7 0.48 10.2 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5318) Zn_ribbon_17 PF17120.5 EFC36916.1 - 1.4 8.6 10.8 0.4 10.3 7.3 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 EFC36916.1 - 2.3 8.2 13.9 5.2 7.1 13.9 1.7 1 0 0 1 1 1 0 PHD-finger F-box PF00646.33 EFC36918.1 - 2.7e-05 23.9 0.8 0.00024 20.9 0.3 2.9 2 0 0 2 2 2 1 F-box domain LRR_4 PF12799.7 EFC36918.1 - 0.0003 21.1 43.0 0.32 11.5 0.4 8.1 5 3 2 7 7 7 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC36918.1 - 0.0049 16.7 0.5 0.014 15.2 0.5 1.8 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC36918.1 - 1.7 9.5 14.2 33 5.6 0.2 6.5 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC36918.1 - 3 8.1 15.2 6.8 7.0 0.0 5.6 6 0 0 6 6 6 0 Leucine Rich repeat DUF1647 PF07801.11 EFC36918.1 - 5.6 6.7 11.3 6.7 6.5 5.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1647) RGS PF00615.19 EFC36919.1 - 6.2e-08 32.9 13.7 3.9e-07 30.3 0.5 3.1 4 0 0 4 4 4 2 Regulator of G protein signaling domain NAAA-beta PF15508.6 EFC36919.1 - 0.066 13.5 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase HMw1_D2 PF18254.1 EFC36920.1 - 0.083 13.3 0.1 0.13 12.6 0.1 1.4 1 0 0 1 1 1 0 HMW1 domain 2 Acetyltransf_2 PF00797.17 EFC36921.1 - 1.1e-37 130.1 0.0 2.5e-36 125.7 0.0 2.3 1 1 0 1 1 1 1 N-acetyltransferase RGS PF00615.19 EFC36922.1 - 7.4e-14 52.0 5.0 4.4e-06 27.0 0.8 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain SafA PF17073.5 EFC36922.1 - 0.0076 16.2 3.9 0.21 11.6 0.2 3.5 3 0 0 3 3 3 2 Two-component-system connector protein DDE_3 PF13358.6 EFC36924.1 - 1.4e-06 28.2 0.9 0.00013 21.8 0.9 2.8 1 1 0 1 1 1 1 DDE superfamily endonuclease DUF4140 PF13600.6 EFC36928.1 - 0.02 15.3 1.5 0.02 15.3 0.3 1.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Med4 PF10018.9 EFC36928.1 - 0.42 10.3 13.8 0.094 12.4 10.3 1.7 2 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Exonuc_VII_L PF02601.15 EFC36928.1 - 5.8 6.4 9.2 6.9 6.1 9.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EFC36928.1 - 6.4 6.0 7.1 8 5.7 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LRR_6 PF13516.6 EFC36929.1 - 1.3e-20 71.6 0.7 0.00042 20.2 0.0 5.8 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.7 EFC36929.1 - 1e-13 51.2 0.1 8.8e-05 22.8 0.0 4.2 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC36929.1 - 6.9e-12 45.0 0.0 1.1e-06 28.3 0.0 2.9 3 0 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EFC36929.1 - 8.9e-05 22.5 0.0 37 5.4 0.0 5.9 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC36929.1 - 0.026 14.0 0.0 0.15 11.6 0.0 2.1 1 1 0 2 2 2 0 Leucine-rich repeat DUF1340 PF07067.11 EFC36929.1 - 0.032 13.6 0.5 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1340) Dynein_heavy PF03028.15 EFC36929.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain RCC1_2 PF13540.6 EFC36930.1 - 2.8e-06 27.0 0.2 3.7e-05 23.4 0.1 2.9 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Helicase_C PF00271.31 EFC36931.1 - 2.8e-05 24.4 0.0 0.00034 20.9 0.0 2.6 2 2 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC36931.1 - 0.033 13.9 0.0 0.097 12.4 0.0 1.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase RCC1 PF00415.18 EFC36932.1 - 1.5e-06 28.8 0.0 0.0082 16.7 0.0 3.0 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC36932.1 - 3e-06 26.9 4.2 0.047 13.5 0.0 3.6 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat XET_C PF06955.12 EFC36932.1 - 0.17 11.7 1.0 0.38 10.6 1.0 1.5 1 0 0 1 1 1 0 Xyloglucan endo-transglycosylase (XET) C-terminus CitMHS PF03600.16 EFC36933.1 - 2.8e-07 30.0 23.3 4.3e-07 29.4 23.3 1.2 1 0 0 1 1 1 1 Citrate transporter Na_sulph_symp PF00939.19 EFC36933.1 - 9.6e-07 28.2 22.9 1.3e-06 27.8 22.9 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region DctM PF06808.12 EFC36933.1 - 0.0039 16.1 15.8 0.0039 16.1 15.8 1.6 1 1 1 2 2 2 1 Tripartite ATP-independent periplasmic transporter, DctM component EF-hand_7 PF13499.6 EFC36934.1 - 2.1e-19 69.7 9.7 8e-10 39.0 0.9 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC36934.1 - 8.7e-18 62.5 16.2 1.9e-05 23.9 0.5 5.0 6 0 0 6 6 6 3 EF hand EF-hand_5 PF13202.6 EFC36934.1 - 3.5e-17 61.0 12.0 0.00016 21.0 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EFC36934.1 - 6.5e-17 60.0 13.3 6.8e-05 22.5 0.4 5.7 5 1 1 6 6 6 3 EF-hand domain EF-hand_8 PF13833.6 EFC36934.1 - 8.8e-12 44.7 12.2 5.7e-06 26.1 0.4 4.8 3 2 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC36934.1 - 0.006 16.9 2.2 7 7.0 0.2 3.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 EFC36934.1 - 0.034 14.5 0.2 0.034 14.5 0.2 2.5 3 0 0 3 3 3 0 EF-hand domain p25-alpha PF05517.12 EFC36934.1 - 0.073 13.2 0.6 1.1 9.4 0.1 2.3 2 1 0 2 2 2 0 p25-alpha La PF05383.17 EFC36934.1 - 0.11 12.6 0.1 1.7 8.8 0.0 2.8 2 1 1 3 3 3 0 La domain Peptidase_S10 PF00450.22 EFC36935.1 - 4e-114 382.3 3.5 4.6e-114 382.1 3.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase FHA PF00498.26 EFC36936.1 - 2.1e-11 44.0 0.5 6.8e-11 42.4 0.2 2.0 2 1 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 EFC36936.1 - 9e-07 29.1 0.0 7.4e-06 26.2 0.0 2.4 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Mannitol_dh PF01232.23 EFC36936.1 - 7.2 6.8 9.8 2.2 8.4 6.7 1.7 2 0 0 2 2 2 0 Mannitol dehydrogenase Rossmann domain BTB_2 PF02214.22 EFC36937.1 - 0.0015 18.8 0.6 0.0098 16.2 0.1 2.3 2 1 0 2 2 2 1 BTB/POZ domain Nsp1_C PF05064.13 EFC36937.1 - 0.0045 16.8 1.3 0.0076 16.0 1.3 1.3 1 0 0 1 1 1 1 Nsp1-like C-terminal region HetR_C PF18460.1 EFC36937.1 - 0.012 15.5 0.2 0.033 14.1 0.1 1.8 1 1 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain HARP PF07443.13 EFC36937.1 - 0.065 12.9 0.9 0.28 10.9 0.9 2.0 1 1 0 1 1 1 0 HepA-related protein (HARP) ADIP PF11559.8 EFC36937.1 - 2.4 8.3 7.3 0.69 10.0 3.5 1.8 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Mst1_SARAH PF11629.8 EFC36937.1 - 3.9 7.6 6.8 2.7 8.1 0.1 3.0 3 0 0 3 3 3 0 C terminal SARAH domain of Mst1 TLD PF07534.16 EFC36938.1 - 1.6e-20 73.8 4.1 2.2e-20 73.3 4.1 1.2 1 0 0 1 1 1 1 TLD BCDHK_Adom3 PF10436.9 EFC36939.1 - 1.8e-38 131.9 0.3 3.1e-38 131.1 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFC36939.1 - 2.9e-13 50.3 0.0 6.6e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFC36939.1 - 8.8e-05 22.3 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sorb PF02208.16 EFC36939.1 - 0.18 11.7 0.3 0.56 10.1 0.0 1.9 2 0 0 2 2 2 0 Sorbin homologous domain Aminotran_1_2 PF00155.21 EFC36940.1 - 7.5e-39 133.9 0.0 1.2e-38 133.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFC36940.1 - 0.098 11.2 0.0 0.19 10.2 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF2400 PF09674.10 EFC36941.1 - 1.6 8.7 5.6 0.41 10.6 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) PHM7_cyt PF14703.6 EFC36942.1 - 2.9e-11 43.9 0.5 2.9e-11 43.9 0.5 2.1 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EFC36942.1 - 6.6e-10 39.0 4.6 6.6e-10 39.0 4.6 4.0 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport RSN1_7TM PF02714.15 EFC36942.1 - 1e-08 34.9 24.3 1e-08 34.9 24.3 4.1 2 2 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PSI PF01437.25 EFC36942.1 - 0.15 12.6 2.6 0.34 11.5 2.6 1.6 1 0 0 1 1 1 0 Plexin repeat Dynamin_N PF00350.23 EFC36943.1 - 2.8e-13 50.3 0.6 6.9e-13 49.0 0.0 2.0 2 0 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 EFC36943.1 - 5.8e-05 23.1 0.2 0.00039 20.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EFC36943.1 - 0.00028 21.4 0.2 0.0015 19.1 0.0 2.3 2 0 0 2 2 2 1 ABC transporter MMR_HSR1 PF01926.23 EFC36943.1 - 0.00043 20.3 0.0 0.004 17.2 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase LPD25 PF18840.1 EFC36943.1 - 0.028 15.0 0.1 0.15 12.6 0.1 2.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 25 YqaJ PF09588.10 EFC36943.1 - 0.18 12.0 1.5 7.7 6.7 0.2 2.6 2 0 0 2 2 2 0 YqaJ-like viral recombinase domain SPATA1_C PF15743.5 EFC36943.1 - 4.2 7.4 5.9 1.9 8.5 2.6 2.1 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus DUF713 PF05218.14 EFC36944.1 - 0.024 14.4 2.0 0.026 14.3 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF713) Syntaxin_2 PF14523.6 EFC36944.1 - 0.12 12.8 9.3 0.15 12.4 0.2 3.3 3 1 0 3 3 3 0 Syntaxin-like protein IFT20 PF14931.6 EFC36944.1 - 1.1 9.5 5.8 5 7.3 0.3 3.1 3 0 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 ZZ PF00569.17 EFC36945.1 - 2.4e-10 40.1 6.8 4.4e-10 39.2 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 EFC36945.1 - 2.5e-06 27.3 0.2 4.5e-06 26.5 0.2 1.3 1 0 0 1 1 1 1 PB1 domain DUF1015 PF06245.11 EFC36945.1 - 0.013 14.4 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) DUF4761 PF15958.5 EFC36945.1 - 0.14 12.3 0.1 0.35 11.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4761) GET2 PF08690.10 EFC36945.1 - 0.77 9.4 8.0 6 6.5 1.5 3.1 3 0 0 3 3 3 0 GET complex subunit GET2 Acylphosphatase PF00708.18 EFC36946.1 - 5.7e-06 26.7 0.1 1.2e-05 25.6 0.1 1.7 1 1 0 1 1 1 1 Acylphosphatase Pkinase PF00069.25 EFC36948.1 - 6.1e-67 225.7 0.1 7.2e-67 225.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36948.1 - 2.3e-18 66.5 0.0 3.5e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC36948.1 - 7.6e-09 35.8 0.0 1.1e-06 28.8 0.0 2.4 2 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC36948.1 - 0.0072 15.2 0.1 0.021 13.6 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 EFC36948.1 - 0.016 14.8 0.1 0.039 13.5 0.1 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EFC36948.1 - 0.023 14.1 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC36948.1 - 0.13 11.6 0.1 0.62 9.3 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Pkinase PF00069.25 EFC36951.1 - 1.4e-56 191.8 0.0 2.2e-56 191.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC36951.1 - 7.7e-26 90.9 0.0 1.1e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase GST_C_3 PF14497.6 EFC36952.1 - 9.7e-12 45.0 0.0 2.4e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC36952.1 - 1.6e-06 28.4 0.9 0.00019 21.7 0.1 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC36952.1 - 1.4e-05 25.2 0.0 3e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain CoA_binding_2 PF13380.6 EFC36952.1 - 0.15 12.5 0.0 0.27 11.8 0.0 1.3 1 0 0 1 1 1 0 CoA binding domain Guanylate_cyc PF00211.20 EFC36954.1 - 2.1e-05 24.2 0.1 4.4e-05 23.2 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC36954.1 - 0.011 15.5 0.2 0.011 15.5 0.2 1.7 2 0 0 2 2 2 0 Cache domain Phage_holin_3_6 PF07332.11 EFC36954.1 - 2.4 8.2 5.0 0.86 9.7 0.2 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III CoaE PF01121.20 EFC36956.1 - 1.3e-21 77.1 4.6 1.4e-19 70.4 1.0 2.1 2 0 0 2 2 2 2 Dephospho-CoA kinase AAA_18 PF13238.6 EFC36956.1 - 0.042 14.4 0.9 0.49 10.9 0.8 2.3 1 1 0 1 1 1 0 AAA domain STAR_dimer PF16544.5 EFC36956.1 - 0.21 11.2 1.0 12 5.6 0.0 2.7 3 0 0 3 3 3 0 Homodimerisation region of STAR domain protein RGS PF00615.19 EFC36957.1 - 7e-19 68.2 21.9 2.5e-11 43.9 4.4 4.2 4 2 1 5 5 5 2 Regulator of G protein signaling domain DEP PF00610.21 EFC36957.1 - 0.025 14.6 0.2 0.13 12.3 0.1 2.3 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ORF6C PF10552.9 EFC36957.1 - 0.054 13.6 2.2 0.12 12.4 0.9 2.3 2 0 0 2 2 2 0 ORF6C domain DUF3921 PF13060.6 EFC36957.1 - 0.056 13.5 0.2 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3921) ADH_N_2 PF16884.5 EFC36958.1 - 2.6e-21 75.5 0.0 5.4e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFC36958.1 - 7.3e-18 64.8 0.0 1.2e-17 64.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC36958.1 - 5.4e-10 40.4 0.0 1.7e-09 38.8 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Gly_kinase PF02595.15 EFC36958.1 - 0.032 13.3 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 Glycerate kinase family Terminase_6C PF17289.2 EFC36958.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.6 1 1 0 1 1 1 0 Terminase RNaseH-like domain PALP PF00291.25 EFC36958.1 - 0.17 11.2 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme WD40 PF00400.32 EFC36960.1 - 4.9e-37 125.3 18.4 5.1e-09 36.6 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36960.1 - 7.4e-14 51.8 0.1 0.017 15.4 0.0 6.4 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC36960.1 - 1.2e-05 25.3 0.0 0.0089 15.9 0.0 2.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFC36960.1 - 0.00011 21.3 1.3 1.7 7.5 0.0 3.6 2 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein CshA_NR2 PF18651.1 EFC36960.1 - 0.13 11.4 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Surface adhesin CshA non-repetitive domain 2 DUF305 PF03713.13 EFC36961.1 - 0.013 15.6 0.1 0.022 14.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF305) Vps51 PF08700.11 EFC36961.1 - 0.09 12.9 2.3 2 8.5 0.1 2.7 2 1 0 2 2 2 0 Vps51/Vps67 Pro_CA PF00484.19 EFC36963.1 - 3.3e-50 170.4 1.3 6.2e-50 169.5 1.3 1.5 1 0 0 1 1 1 1 Carbonic anhydrase SpoU_methylase PF00588.19 EFC36964.1 - 3.6e-28 98.5 0.0 3.4e-26 92.1 0.0 2.2 1 1 0 1 1 1 1 SpoU rRNA Methylase family DUF1304 PF06993.12 EFC36967.1 - 3.1e-33 114.0 10.7 4.4e-33 113.6 10.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) Ras PF00071.22 EFC36968.1 - 1.3e-19 70.4 0.0 2.6e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC36968.1 - 1.6e-06 28.3 0.0 6.2e-06 26.4 0.0 1.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ADH_zinc_N_2 PF13602.6 EFC36970.1 - 4.9e-09 37.3 0.1 6.1e-08 33.8 0.1 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC36970.1 - 0.0039 17.2 0.0 0.0074 16.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NHL PF01436.21 EFC36971.1 - 3.5e-24 83.6 9.4 1.6e-05 24.7 0.1 6.1 5 0 0 5 5 5 5 NHL repeat BTB PF00651.31 EFC36971.1 - 7.1e-11 42.3 0.4 2e-10 40.9 0.4 1.8 1 0 0 1 1 1 1 BTB/POZ domain Linker_histone PF00538.19 EFC36971.1 - 1.3e-06 28.6 1.8 9 6.7 0.0 6.4 6 0 0 6 6 6 1 linker histone H1 and H5 family Plasmo_rep PF12135.8 EFC36971.1 - 0.025 14.1 21.3 3.8 7.1 0.6 6.2 5 0 0 5 5 5 0 Plasmodium repeat family HP1451_C PF18472.1 EFC36971.1 - 0.16 12.0 0.5 7.8 6.6 0.0 3.9 5 0 0 5 5 5 0 HP1451 C-terminal domain DUF4244 PF14029.6 EFC36972.1 - 0.12 11.9 0.3 0.22 11.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) TK PF00265.18 EFC36973.1 - 1.8e-65 220.1 0.3 2.2e-65 219.8 0.3 1.1 1 0 0 1 1 1 1 Thymidine kinase UCH PF00443.29 EFC36974.1 - 5.2e-13 49.1 0.0 1e-12 48.1 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC36974.1 - 5.6e-06 26.2 0.8 6.2e-05 22.7 0.5 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase F-box-like PF12937.7 EFC36975.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 F-box-like Carbam_trans_C PF16861.5 EFC36975.1 - 0.11 12.0 0.4 0.2 11.2 0.4 1.3 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus DNA_ligase_A_M PF01068.21 EFC36977.1 - 6.6e-50 169.6 2.8 1.3e-49 168.6 1.4 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFC36977.1 - 7.3e-29 101.3 2.9 3.4e-28 99.1 2.9 2.3 1 0 0 1 1 1 1 DNA ligase N terminus Pkinase PF00069.25 EFC36977.1 - 8.8e-17 61.3 0.0 2.8e-16 59.7 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain DNA_ligase_A_C PF04679.15 EFC36977.1 - 8e-13 48.8 0.0 2.5e-12 47.3 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region GST_C_3 PF14497.6 EFC36977.1 - 4.8e-11 42.7 0.8 4.6e-10 39.6 0.0 3.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain RNA_ligase PF09414.10 EFC36977.1 - 8.8e-09 35.9 0.6 3.2e-08 34.1 0.6 2.0 1 0 0 1 1 1 1 RNA ligase GST_C PF00043.25 EFC36977.1 - 0.00024 21.3 0.0 0.0012 19.1 0.0 2.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase_Tyr PF07714.17 EFC36977.1 - 0.00026 20.4 0.0 0.00064 19.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase GST_N PF02798.20 EFC36977.1 - 0.0059 16.9 0.0 0.0059 16.9 0.0 2.8 3 0 0 3 3 2 1 Glutathione S-transferase, N-terminal domain SDA1 PF05285.12 EFC36977.1 - 0.2 11.0 59.0 0.35 10.2 19.8 2.5 2 0 0 2 2 2 0 SDA1 TfoX_C PF04994.13 EFC36977.1 - 0.39 10.8 3.4 0.84 9.8 0.1 3.1 4 0 0 4 4 4 0 TfoX C-terminal domain CDC45 PF02724.14 EFC36977.1 - 2.7 6.2 43.5 1.8 6.8 22.0 2.2 2 0 0 2 2 2 0 CDC45-like protein Velvet PF11754.8 EFC36977.1 - 3.5 7.5 11.0 1.1 9.2 3.3 2.3 2 0 0 2 2 2 0 Velvet factor Apt1 PF10351.9 EFC36977.1 - 3.9 6.2 33.6 2.4 6.9 13.5 2.5 2 0 0 2 2 2 0 Golgi-body localisation protein domain DUF4604 PF15377.6 EFC36977.1 - 5.7 7.3 61.0 1.9 8.9 29.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Presenilin PF01080.17 EFC36977.1 - 9.5 4.9 32.9 3.1 6.5 7.5 2.2 2 0 0 2 2 2 0 Presenilin Ependymin PF00811.18 EFC36979.1 - 0.026 14.8 0.2 0.073 13.3 0.0 2.0 2 1 0 2 2 2 0 Ependymin SHOCT PF09851.9 EFC36980.1 - 8.4e-21 73.1 28.5 4e-08 32.7 5.4 4.7 4 0 0 4 4 4 4 Short C-terminal domain DUF1707 PF08044.11 EFC36980.1 - 0.00034 20.6 1.1 6.2 7.0 0.1 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF1707) GvpG PF05120.12 EFC36980.1 - 0.033 14.2 19.9 0.18 11.8 1.7 3.7 3 0 0 3 3 3 0 Gas vesicle protein G CARD PF00619.21 EFC36980.1 - 1.2 9.3 8.6 1.9 8.6 0.2 3.8 3 0 0 3 3 3 0 Caspase recruitment domain GlnD_UR_UTase PF08335.11 EFC36980.1 - 1.2 9.2 11.2 6.6 6.8 0.2 3.7 3 1 1 4 4 4 0 GlnD PII-uridylyltransferase Bac_small_YrzI PF09501.10 EFC36980.1 - 7.5 6.8 7.7 27 5.0 0.9 3.8 1 1 1 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) RWP-RK PF02042.15 EFC36981.1 - 4.1e-09 36.3 0.0 1.1e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 RWP-RK domain HTH_8 PF02954.19 EFC36981.1 - 0.0081 15.9 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, Fis family HTH_psq PF05225.16 EFC36981.1 - 0.016 14.9 0.2 0.032 14.0 0.2 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_23 PF13384.6 EFC36981.1 - 0.021 14.6 0.0 0.041 13.7 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_3 PF01381.22 EFC36981.1 - 0.036 14.1 0.1 0.073 13.1 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix TRM13 PF05206.14 EFC36981.1 - 0.049 13.1 1.6 0.087 12.3 1.6 1.4 1 0 0 1 1 1 0 Methyltransferase TRM13 HTH_17 PF12728.7 EFC36981.1 - 0.097 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.15 EFC36981.1 - 0.15 12.1 0.2 0.42 10.7 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HEPN_MAE_28990 PF18737.1 EFC36981.1 - 0.2 11.5 4.2 0.14 12.1 0.8 2.1 2 1 0 2 2 2 0 MAE_28990/MAE_18760-like HEPN Sel1 PF08238.12 EFC36982.1 - 1.4e-20 73.2 6.7 2e-06 28.3 0.1 4.6 4 0 0 4 4 4 4 Sel1 repeat WD40 PF00400.32 EFC36982.1 - 9.2e-12 45.3 0.2 0.083 13.8 0.0 6.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC36982.1 - 5e-06 26.7 0.0 0.028 14.7 0.0 4.3 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Laminin_G_3 PF13385.6 EFC36983.1 - 7.9e-20 71.5 3.7 1.1e-19 71.1 3.2 1.5 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 EFC36983.1 - 0.00022 21.5 5.0 0.00022 21.5 5.0 2.2 2 0 0 2 2 2 1 EGF-like domain AAA PF00004.29 EFC36984.1 - 1.6e-08 35.1 0.2 3.5e-08 34.0 0.1 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC36984.1 - 0.0014 18.3 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain KAP_NTPase PF07693.14 EFC36984.1 - 0.0079 15.5 1.1 0.34 10.1 0.2 2.2 2 0 0 2 2 2 2 KAP family P-loop domain Vps4_C PF09336.10 EFC36984.1 - 0.057 13.4 1.5 0.099 12.7 0.1 2.1 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain EGF_2 PF07974.13 EFC36985.1 - 0.00047 20.5 5.0 0.00047 20.5 5.0 2.4 2 0 0 2 2 2 1 EGF-like domain AAA PF00004.29 EFC36986.1 - 1.5e-08 35.1 0.3 3.5e-08 34.0 0.1 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC36986.1 - 0.00085 19.1 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain KAP_NTPase PF07693.14 EFC36986.1 - 0.012 14.8 1.2 0.52 9.5 0.3 2.2 2 0 0 2 2 2 0 KAP family P-loop domain Vps4_C PF09336.10 EFC36986.1 - 0.057 13.4 1.5 0.099 12.7 0.1 2.1 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain DUF637 PF04830.13 EFC36988.1 - 5 6.9 5.7 5.6 6.7 3.6 2.1 1 1 1 2 2 2 0 Possible hemagglutinin (DUF637) Cupin_8 PF13621.6 EFC36989.1 - 0.00069 19.4 6.6 0.024 14.3 0.3 3.2 2 1 0 3 3 3 2 Cupin-like domain DUF4019 PF13211.6 EFC36989.1 - 0.0036 17.7 0.1 0.012 15.9 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4019) AAA PF00004.29 EFC36990.1 - 1e-42 145.7 0.4 2.9e-42 144.2 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 EFC36990.1 - 4.4e-20 71.4 0.6 8.3e-20 70.5 0.6 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 EFC36990.1 - 8.6e-11 41.5 0.6 2e-10 40.3 0.1 1.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 EFC36990.1 - 2.5e-06 28.0 0.7 0.00059 20.3 0.1 2.6 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFC36990.1 - 7.4e-06 26.0 0.9 3.1e-05 24.0 0.1 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFC36990.1 - 5.2e-05 23.0 0.0 0.00018 21.3 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFC36990.1 - 7e-05 23.0 0.4 0.00066 19.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFC36990.1 - 0.00013 22.2 0.4 0.021 15.1 0.1 2.6 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFC36990.1 - 0.0019 17.6 0.0 0.0062 15.9 0.0 1.8 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 EFC36990.1 - 0.0043 16.5 0.1 0.036 13.5 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_33 PF13671.6 EFC36990.1 - 0.011 15.9 0.0 0.025 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFC36990.1 - 0.013 14.7 0.0 0.027 13.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 EFC36990.1 - 0.018 14.8 0.1 0.038 13.7 0.1 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EFC36990.1 - 0.022 14.1 0.7 0.078 12.3 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_7 PF12775.7 EFC36990.1 - 0.029 13.9 0.0 0.088 12.3 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFC36990.1 - 0.036 13.8 0.0 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 EFC36990.1 - 0.042 13.6 3.6 0.096 12.4 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFC36990.1 - 0.065 12.8 1.5 0.33 10.5 0.2 2.4 2 1 1 3 3 2 0 AAA domain AAA_18 PF13238.6 EFC36990.1 - 0.068 13.7 0.2 0.29 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFC36990.1 - 0.089 12.5 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFC36990.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EFC36990.1 - 0.14 12.6 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Prot_ATP_OB_N PF17758.1 EFC36990.1 - 0.15 11.8 0.0 0.58 9.8 0.0 2.0 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_11 PF13086.6 EFC36990.1 - 0.17 11.6 2.3 0.65 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFC36990.1 - 0.23 11.3 4.9 8.5 6.2 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 EFC36990.1 - 2.4 8.7 5.6 4.4 7.8 0.0 2.9 3 1 0 3 3 2 0 ABC transporter Aminotran_1_2 PF00155.21 EFC36992.1 - 9.8e-60 202.6 0.0 1.1e-59 202.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFC36992.1 - 2e-05 23.3 0.0 3e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 EFC36992.1 - 3.6e-05 23.2 0.0 5.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 EFC36992.1 - 4.5e-05 22.9 0.0 6.5e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EFC36992.1 - 0.00023 20.2 0.0 0.00049 19.2 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V DUF262 PF03235.14 EFC36992.1 - 0.17 12.1 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF4422 PF14393.6 EFC36993.1 - 0.074 12.9 3.2 0.1 12.4 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4422) DUF778 PF05608.12 EFC36993.1 - 0.078 13.3 0.2 0.095 13.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) DUF1757 PF08560.10 EFC36994.1 - 4.7e-11 42.9 0.0 6.5e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1757) TPR_12 PF13424.6 EFC36995.1 - 3.4e-16 59.3 0.0 2.8e-13 50.0 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC36995.1 - 2e-07 30.5 0.0 0.04 13.7 0.0 3.5 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC36995.1 - 7.2e-07 28.9 0.0 0.0034 17.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC36995.1 - 2.6e-06 27.1 0.0 0.23 11.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC36995.1 - 4.8e-05 23.2 1.8 0.17 12.2 0.1 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC36995.1 - 0.0007 19.1 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region SHNi-TPR PF10516.9 EFC36995.1 - 0.0022 17.4 0.0 0.84 9.2 0.0 2.6 2 0 0 2 2 2 2 SHNi-TPR TPR_7 PF13176.6 EFC36995.1 - 0.11 12.6 0.1 31 4.9 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2811 PF10929.8 EFC36995.1 - 0.42 10.9 1.8 0.73 10.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2811) SNF2_N PF00176.23 EFC36996.1 - 6.5e-44 150.1 1.6 3.9e-43 147.5 1.6 2.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC36996.1 - 3e-18 66.2 1.2 2.6e-17 63.1 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC36996.1 - 1.1e-07 32.1 0.2 1.1e-07 32.1 0.2 3.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFC36996.1 - 0.0024 17.1 0.2 0.0024 17.1 0.2 2.7 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase Acyl-CoA_ox_N PF14749.6 EFC36996.1 - 2.9 8.5 10.5 3 8.4 1.1 4.0 4 0 0 4 4 4 0 Acyl-coenzyme A oxidase N-terminal DUF4064 PF13273.6 EFC36997.1 - 8.9 6.6 10.3 0.19 12.0 1.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) TBPIP PF07106.13 EFC36998.1 - 2e-18 66.0 0.2 8.2e-18 64.1 0.3 2.1 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 EFC36998.1 - 3.8e-08 33.3 0.1 3.8e-08 33.3 0.1 2.5 2 1 0 2 2 2 1 Leucine zipper with capping helix domain TFIIE_beta PF02186.15 EFC36998.1 - 0.16 12.2 6.3 0.26 11.6 0.1 2.9 3 1 0 3 3 3 0 TFIIE beta subunit core domain MCM_bind PF09739.9 EFC36998.1 - 0.22 9.9 9.9 0.4 9.1 9.9 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF789 PF05623.12 EFC36998.1 - 1.4 8.6 6.6 2.6 7.7 6.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) PIP49_N PF14875.6 EFC36998.1 - 4.6 7.1 8.8 9 6.1 0.2 2.7 2 2 0 2 2 2 0 N-term cysteine-rich ER, FAM69 Prenyltrans PF00432.21 EFC36999.1 - 4.8e-63 208.6 6.9 1.1e-14 53.9 0.0 5.3 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 EFC36999.1 - 0.0041 16.3 0.0 7.2 5.6 0.0 3.6 2 2 3 5 5 5 2 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 EFC36999.1 - 0.0068 15.5 0.0 0.017 14.3 0.0 1.7 1 1 0 1 1 1 1 Squalene-hopene cyclase C-terminal domain LRR_4 PF12799.7 EFC37000.1 - 6.2e-13 48.7 37.3 6.7e-05 23.2 4.2 8.0 6 1 1 7 7 7 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC37000.1 - 1.1e-06 28.2 28.9 0.026 14.6 0.4 9.5 9 0 0 9 9 9 3 Leucine Rich repeat LRR_1 PF00560.33 EFC37000.1 - 0.0091 16.4 31.2 4.4 8.2 1.6 8.7 11 0 0 11 11 11 4 Leucine Rich Repeat LRR_8 PF13855.6 EFC37000.1 - 2.5 7.9 30.7 1.2 9.0 0.2 8.3 7 2 2 9 9 9 0 Leucine rich repeat Peptidase_C1 PF00112.23 EFC37001.1 - 3.2e-32 112.4 0.9 4.7e-32 111.8 0.9 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC37001.1 - 9.6e-05 22.2 0.9 0.00017 21.4 0.9 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide MLANA PF14991.6 EFC37001.1 - 0.14 12.4 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein melan-A PLA2G12 PF06951.11 EFC37002.1 - 4.9e-21 75.4 17.1 6e-21 75.2 17.1 1.1 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Phospholip_A2_3 PF09056.11 EFC37002.1 - 0.00026 21.6 8.8 0.00061 20.4 8.8 1.7 1 1 0 1 1 1 1 Prokaryotic phospholipase A2 EGF_2 PF07974.13 EFC37003.1 - 1.2e-17 64.0 140.6 0.00044 20.6 9.5 11.0 10 1 0 10 10 10 7 EGF-like domain F-box PF00646.33 EFC37005.1 - 0.11 12.3 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 F-box domain DUF5408 PF17402.2 EFC37006.1 - 0.0056 16.5 0.0 0.12 12.3 0.0 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5408) Ras PF00071.22 EFC37007.1 - 2.1e-26 92.4 0.0 2.7e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37007.1 - 1.4e-12 47.9 0.0 2.3e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF2805 PF10985.8 EFC37008.1 - 0.08 13.3 0.1 0.24 11.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) CH PF00307.31 EFC37010.1 - 1.4e-22 79.9 0.0 2.3e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain SHOCT PF09851.9 EFC37010.1 - 6.1e-08 32.2 4.0 1.1e-07 31.4 4.0 1.4 1 0 0 1 1 1 1 Short C-terminal domain SBBP PF06739.11 EFC37010.1 - 0.52 10.4 3.9 48 4.1 0.0 3.9 4 0 0 4 4 4 0 Beta-propeller repeat NmrA PF05368.13 EFC37011.1 - 5.7e-51 173.3 0.1 7.6e-51 172.9 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC37011.1 - 1.7e-17 63.9 0.0 2.8e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC37011.1 - 7.2e-09 35.5 0.2 2.2e-08 33.9 0.2 1.8 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC37011.1 - 2.6e-06 26.6 0.1 3.7e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EFC37011.1 - 2.1e-05 24.8 0.1 4e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EFC37011.1 - 8.1e-05 22.9 0.2 0.00031 21.0 0.1 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFC37011.1 - 0.00017 21.5 0.5 0.00034 20.6 0.2 1.6 2 0 0 2 2 2 1 KR domain DapB_N PF01113.20 EFC37011.1 - 0.0021 18.1 1.4 0.016 15.3 0.2 2.4 1 1 1 2 2 2 1 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 EFC37011.1 - 0.017 15.7 0.3 0.04 14.5 0.3 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EFC37011.1 - 0.044 13.8 0.2 0.093 12.8 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EFC37011.1 - 0.061 13.8 0.2 0.15 12.5 0.1 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain EGF_2 PF07974.13 EFC37012.1 - 0.00073 19.9 20.1 0.05 14.0 4.7 2.5 2 0 0 2 2 2 2 EGF-like domain Metallothi_Euk2 PF12809.7 EFC37012.1 - 2.4 8.5 20.1 13 6.1 8.5 2.4 1 1 1 2 2 2 0 Eukaryotic metallothionein Cpn60_TCP1 PF00118.24 EFC37013.1 - 3.3e-08 32.6 0.3 4.6e-08 32.1 0.3 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family YgbA_NO PF11756.8 EFC37013.1 - 0.0019 18.5 2.9 0.024 15.0 3.0 2.5 3 0 0 3 3 3 1 Nitrous oxide-stimulated promoter BK_channel_a PF03493.18 EFC37014.1 - 5.5e-13 48.9 0.1 4.5e-11 42.8 0.0 2.9 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 EFC37014.1 - 7.9e-13 48.2 7.7 7.9e-13 48.2 7.7 2.0 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.18 EFC37014.1 - 6.4e-08 32.9 0.0 3.1e-05 24.2 0.1 2.9 2 0 0 2 2 2 2 TrkA-N domain Ion_trans PF00520.31 EFC37014.1 - 1.4e-05 24.5 9.4 3e-05 23.4 9.4 1.4 1 0 0 1 1 1 1 Ion transport protein DUF4116 PF13475.6 EFC37015.1 - 1.7e-107 351.0 16.7 3.8e-16 58.6 0.0 8.9 5 2 4 10 10 10 10 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 EFC37015.1 - 0.0014 18.7 2.0 1.2 9.3 0.0 4.3 2 2 2 4 4 4 1 Rsbr N terminal TctC PF03401.14 EFC37015.1 - 0.028 13.5 0.0 3.6 6.6 0.0 3.1 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter family receptor GidB PF02527.15 EFC37015.1 - 0.065 12.6 3.6 1.2 8.5 0.1 2.5 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G FAM194 PF14977.6 EFC37015.1 - 0.16 11.3 1.8 1.3 8.3 0.0 2.6 2 0 0 2 2 2 0 FAM194 protein Peptidase_C25_C PF03785.14 EFC37015.1 - 0.2 11.5 0.0 0.63 9.9 0.0 1.8 1 0 0 1 1 1 0 Peptidase family C25, C terminal ig-like domain N6_N4_Mtase PF01555.18 EFC37015.1 - 3.2 7.4 6.3 15 5.2 1.5 3.1 2 2 0 2 2 2 0 DNA methylase ubiquitin PF00240.23 EFC37016.1 - 4.7e-103 337.0 21.3 2.9e-33 113.4 0.7 4.9 4 1 1 5 5 5 4 Ubiquitin family Rad60-SLD PF11976.8 EFC37016.1 - 1.2e-48 162.8 17.0 6e-16 58.0 0.7 3.8 3 1 1 4 4 4 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC37016.1 - 2.5e-17 63.1 8.2 0.00025 21.4 0.1 4.8 4 3 0 4 4 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC37016.1 - 6.4e-13 48.4 2.5 0.011 15.7 0.0 3.7 3 1 1 4 4 4 3 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC37016.1 - 3.4e-11 43.4 7.4 0.0077 16.6 0.2 3.3 2 1 1 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC37016.1 - 5.9e-11 42.4 3.2 0.058 13.5 0.0 4.4 3 3 1 4 4 4 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC37016.1 - 8e-10 39.2 1.6 0.12 13.0 0.1 3.2 2 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC37016.1 - 5e-07 29.7 2.0 0.35 10.7 0.0 3.9 1 1 2 3 3 3 2 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EFC37016.1 - 7.2e-07 29.2 17.6 4.3 7.5 0.2 6.5 6 1 1 7 7 7 3 Ubiquitin-like domain DUF3861 PF12977.7 EFC37016.1 - 9.6e-05 22.5 1.6 8.7 6.6 0.0 3.5 4 0 0 4 4 3 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 EFC37016.1 - 0.00022 21.0 5.3 9.8 6.1 0.1 4.3 4 0 0 4 4 4 0 ACT domain DUF2870 PF11069.8 EFC37016.1 - 0.00057 20.2 0.1 26 5.3 0.0 4.0 3 3 0 3 3 3 0 Protein of unknown function (DUF2870) RBD PF02196.15 EFC37016.1 - 0.0011 19.0 0.0 20 5.3 0.0 3.7 3 1 1 4 4 4 0 Raf-like Ras-binding domain YcgR_2 PF12945.7 EFC37016.1 - 0.0013 18.9 4.0 19 5.5 0.1 4.0 4 0 0 4 4 4 0 Flagellar protein YcgR Tash_PEST PF07708.11 EFC37016.1 - 0.0019 18.3 11.7 14 6.0 0.2 4.4 4 0 0 4 4 4 0 Tash protein PEST motif Methyltrans_RNA PF04452.14 EFC37016.1 - 0.0022 17.4 0.2 1.1 8.5 0.0 2.5 2 0 0 2 2 2 2 RNA methyltransferase Big_7 PF17957.1 EFC37016.1 - 0.0025 18.6 0.4 1.1e+02 3.6 0.0 4.0 4 0 0 4 4 4 0 Bacterial Ig domain DUF218 PF02698.17 EFC37016.1 - 0.0041 17.1 8.4 0.23 11.5 0.0 4.1 2 2 2 4 4 4 1 DUF218 domain DUF1866 PF08952.11 EFC37016.1 - 0.005 16.7 2.8 33 4.3 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF1866) Phage_sheath_1N PF17481.2 EFC37016.1 - 0.007 16.8 6.9 8.1 7.0 2.7 4.0 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain UN_NPL4 PF11543.8 EFC37016.1 - 0.0089 16.5 4.3 38 4.9 0.0 4.1 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 UDP-g_GGTase PF06427.11 EFC37016.1 - 0.015 15.4 4.4 1.8 8.8 0.1 4.1 3 1 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase ProRS-C_2 PF09181.10 EFC37016.1 - 0.032 14.3 8.5 14 5.9 0.1 3.5 4 0 0 4 4 3 0 Prolyl-tRNA synthetase, C-terminal ACT_4 PF13291.6 EFC37016.1 - 0.065 13.8 2.0 1.2e+02 3.4 0.0 3.9 4 0 0 4 4 4 0 ACT domain PI3K_p85B PF02192.16 EFC37016.1 - 0.079 12.7 7.7 38 4.1 0.1 4.2 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain HAMP_N3 PF18575.1 EFC37016.1 - 0.67 9.6 7.1 48 3.7 0.1 3.8 4 0 0 4 4 4 0 HAMP N-terminal domain 3 Glyco_hydro_65C PF03633.15 EFC37016.1 - 7 6.6 5.8 20 5.2 0.2 3.7 4 0 0 4 4 4 0 Glycosyl hydrolase family 65, C-terminal domain AAA PF00004.29 EFC37017.1 - 1.7e-30 106.1 0.0 2.7e-30 105.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFC37017.1 - 2.9e-05 23.9 0.6 0.00019 21.2 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFC37017.1 - 3.1e-05 24.5 0.0 6.7e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC37017.1 - 4e-05 24.1 0.0 8.4e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC37017.1 - 4.1e-05 23.9 0.0 0.0001 22.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFC37017.1 - 0.0004 20.4 1.0 0.27 11.1 0.0 2.5 1 1 1 2 2 2 2 ATPase domain predominantly from Archaea TsaE PF02367.17 EFC37017.1 - 0.00096 19.2 0.0 0.0018 18.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EFC37017.1 - 0.001 19.5 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 EFC37017.1 - 0.0018 17.9 0.0 0.023 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFC37017.1 - 0.0026 17.5 0.0 0.0054 16.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 EFC37017.1 - 0.0031 17.7 0.0 0.0053 16.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFC37017.1 - 0.0033 16.6 0.1 0.027 13.6 0.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 EFC37017.1 - 0.0035 17.4 0.0 0.0089 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFC37017.1 - 0.0038 17.4 0.0 0.0093 16.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) NACHT PF05729.12 EFC37017.1 - 0.0038 17.1 0.1 0.0081 16.1 0.1 1.7 1 1 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 EFC37017.1 - 0.0053 16.3 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 EFC37017.1 - 0.0059 15.9 0.0 0.0096 15.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_28 PF13521.6 EFC37017.1 - 0.0065 16.7 0.0 0.023 14.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 EFC37017.1 - 0.0068 16.4 0.1 0.018 15.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EFC37017.1 - 0.0098 15.6 0.0 0.027 14.2 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_30 PF13604.6 EFC37017.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFC37017.1 - 0.013 15.3 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_13 PF13166.6 EFC37017.1 - 0.017 13.8 0.0 0.024 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EFC37017.1 - 0.026 14.3 0.1 0.074 12.8 0.1 1.6 1 1 0 1 1 1 0 Cytidylate kinase AAA_17 PF13207.6 EFC37017.1 - 0.03 14.8 0.0 0.056 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 EFC37017.1 - 0.038 13.3 0.0 0.1 11.9 0.0 1.7 1 1 0 1 1 1 0 KaiC AAA_19 PF13245.6 EFC37017.1 - 0.043 14.2 0.1 0.14 12.5 0.0 1.9 2 0 0 2 2 1 0 AAA domain KAP_NTPase PF07693.14 EFC37017.1 - 0.058 12.6 0.0 0.15 11.2 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain Rad17 PF03215.15 EFC37017.1 - 0.086 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 EFC37017.1 - 0.098 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_6 PF12774.7 EFC37017.1 - 0.16 10.9 0.2 0.54 9.2 0.0 1.8 1 1 1 2 2 2 0 Hydrolytic ATP binding site of dynein motor region WD40 PF00400.32 EFC37018.1 - 4.6e-17 62.1 12.0 0.003 18.3 0.1 8.7 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC37018.1 - 2.9e-10 40.3 0.0 0.06 13.6 0.0 5.3 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 EFC37018.1 - 0.00078 18.3 0.2 1.4 7.5 0.0 4.1 2 2 2 4 4 4 2 Nup133 N terminal like Vps16_N PF04841.13 EFC37018.1 - 0.0021 16.9 0.0 0.0048 15.7 0.0 1.7 1 0 0 1 1 1 1 Vps16, N-terminal region Nup160 PF11715.8 EFC37018.1 - 0.016 13.9 0.0 0.033 12.8 0.0 1.5 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Myb_DNA-binding PF00249.31 EFC37019.1 - 5.7e-07 29.6 0.3 1.3e-06 28.5 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC37019.1 - 0.006 16.5 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFC37019.1 - 0.054 13.8 0.1 0.14 12.4 0.1 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF525 PF04379.14 EFC37020.1 - 1.8e-24 85.8 0.4 4.2e-24 84.6 0.4 1.6 1 0 0 1 1 1 1 ApaG domain F-box PF00646.33 EFC37020.1 - 6.8e-08 32.2 0.4 0.0002 21.2 0.2 2.7 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.7 EFC37020.1 - 0.00018 21.3 0.9 0.0065 16.3 0.4 2.5 2 0 0 2 2 2 1 F-box-like adh_short PF00106.25 EFC37021.1 - 2.3e-08 33.7 0.6 3e-07 30.1 0.2 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC37021.1 - 2.6e-06 27.2 0.0 1.2e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Voltage_CLC PF00654.20 EFC37022.1 - 4e-95 319.1 23.9 4e-95 319.1 23.9 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 EFC37022.1 - 2.3e-08 34.3 0.0 0.012 16.0 0.0 2.6 2 0 0 2 2 2 2 CBS domain Per1 PF04080.13 EFC37022.1 - 0.033 13.9 0.5 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Per1-like family Filament PF00038.21 EFC37023.1 - 0.0049 16.5 39.5 0.1 12.1 38.9 2.9 1 1 0 1 1 1 1 Intermediate filament protein FlxA PF14282.6 EFC37023.1 - 0.024 14.6 13.1 0.024 14.6 13.1 4.2 1 1 3 4 4 4 0 FlxA-like protein DUF3584 PF12128.8 EFC37023.1 - 0.11 10.0 38.1 0.14 9.7 38.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Adeno_E1B_19K PF01691.16 EFC37023.1 - 0.13 11.8 0.2 0.13 11.8 0.2 1.8 2 0 0 2 2 2 0 Adenovirus E1B 19K protein / small t-antigen DUF948 PF06103.11 EFC37023.1 - 0.17 12.2 13.9 0.32 11.3 4.0 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) EzrA PF06160.12 EFC37023.1 - 0.82 7.8 40.7 2 6.5 38.4 1.9 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA kleA_kleC PF17383.2 EFC37023.1 - 0.98 9.8 10.6 0.55 10.6 0.2 3.3 2 1 0 3 3 3 0 Uncharacterized KorC regulated protein A FUSC PF04632.12 EFC37023.1 - 1.1 7.8 3.4 1.9 6.9 0.0 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF2894 PF11445.8 EFC37023.1 - 1.1 9.7 11.6 0.31 11.5 8.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2894) Baculo_IE-1 PF05290.11 EFC37023.1 - 2.6 8.0 8.6 0.57 10.1 2.7 2.2 1 1 1 2 2 2 0 Baculovirus immediate-early protein (IE-0) Lebercilin PF15619.6 EFC37023.1 - 2.8 7.5 40.5 32 4.1 35.5 3.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Hydrolase_6 PF13344.6 EFC37023.1 - 4.5 7.4 6.9 41 4.4 3.6 2.9 1 1 2 3 3 3 0 Haloacid dehalogenase-like hydrolase ApoO PF09769.9 EFC37023.1 - 4.6 7.2 13.5 45 4.0 1.9 3.3 1 1 1 2 2 2 0 Apolipoprotein O D123 PF07065.14 EFC37024.1 - 8.5e-16 58.0 2.9 8.5e-16 58.0 2.9 1.7 2 0 0 2 2 2 1 D123 Abhydrolase_1 PF00561.20 EFC37024.1 - 1.2e-08 35.0 0.2 0.0003 20.5 0.0 3.1 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EFC37024.1 - 4.9e-07 29.8 0.0 1.1e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 EFC37024.1 - 0.0018 17.6 0.0 0.049 12.9 0.0 3.1 4 1 0 4 4 4 1 Serine aminopeptidase, S33 R2K_3 PF14243.6 EFC37024.1 - 0.013 15.5 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EFC37024.1 - 0.02 14.8 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Peptidase_S9 PF00326.21 EFC37024.1 - 0.11 12.0 0.0 0.28 10.6 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFC37024.1 - 0.15 12.7 0.0 3.7 8.1 0.0 2.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Dyp_perox PF04261.12 EFC37025.1 - 2.9e-45 154.7 0.4 8.8e-45 153.1 0.4 1.7 1 1 0 1 1 1 1 Dyp-type peroxidase family G-alpha PF00503.20 EFC37026.1 - 3e-34 118.7 6.6 6e-34 117.8 6.6 1.4 1 0 0 1 1 1 1 G-protein alpha subunit Peptidase_M20 PF01546.28 EFC37026.1 - 2.4e-29 102.5 0.0 3.8e-29 101.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC37026.1 - 2.4e-12 46.7 0.0 6.5e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Arf PF00025.21 EFC37026.1 - 1.8e-05 24.3 0.1 4.2e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Peptidase_M42 PF05343.14 EFC37026.1 - 0.00016 20.8 0.0 0.00039 19.6 0.0 1.6 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Neuropep_like PF15161.6 EFC37026.1 - 0.12 12.0 0.9 0.27 10.9 0.2 1.9 2 0 0 2 2 2 0 Neuropeptide-like Erf4 PF10256.9 EFC37027.1 - 5.2e-05 23.3 0.2 0.0001 22.4 0.2 1.6 1 1 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family MerC PF03203.14 EFC37027.1 - 0.029 14.8 0.3 0.036 14.5 0.3 1.1 1 0 0 1 1 1 0 MerC mercury resistance protein DUF3624 PF12292.8 EFC37027.1 - 0.93 9.9 3.9 16 6.0 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3624) RCC1_2 PF13540.6 EFC37028.1 - 0.087 12.6 0.0 0.79 9.6 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat DUF5500 PF17604.2 EFC37028.1 - 0.17 12.0 0.2 0.78 9.9 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5500) DSPc PF00782.20 EFC37029.1 - 4.2e-05 23.4 1.3 4.9e-05 23.1 0.1 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC37029.1 - 9.9e-05 22.0 0.0 0.00014 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC37029.1 - 0.00016 21.4 0.1 0.0013 18.5 0.1 2.0 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EFC37029.1 - 0.0043 17.1 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFC37029.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EFC37029.1 - 0.074 12.6 0.2 0.074 12.6 0.2 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family Peptidase_S58 PF03576.14 EFC37030.1 - 3.4e-41 141.7 0.3 8.4e-41 140.4 0.3 1.6 1 1 0 1 1 1 1 Peptidase family S58 F-box-like_2 PF13013.6 EFC37030.1 - 0.13 12.3 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 F-box-like domain HATPase_c_3 PF13589.6 EFC37031.1 - 1.4e-11 44.4 0.7 1.4e-10 41.1 0.7 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFC37031.1 - 1.2e-06 29.0 0.3 3.4e-06 27.5 0.3 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ING PF12998.7 EFC37032.1 - 4.1e-10 40.1 5.0 2.1e-09 37.9 5.0 2.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 EFC37032.1 - 0.00053 19.8 8.5 0.00099 19.0 8.5 1.5 1 0 0 1 1 1 1 PHD-finger DUF2935 PF11155.8 EFC37032.1 - 0.07 13.5 0.3 1.5 9.1 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) BLOC1_2 PF10046.9 EFC37032.1 - 0.19 12.0 5.7 0.9 9.9 1.4 2.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Methyltransf_11 PF08241.12 EFC37033.1 - 1.2e-14 54.7 0.0 1.7e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC37033.1 - 3e-13 50.3 0.0 4.9e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC37033.1 - 4.1e-07 29.9 0.0 4.6e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC37033.1 - 2.2e-06 28.3 0.0 3.4e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC37033.1 - 3.8e-06 26.4 0.0 4.7e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC37033.1 - 7.9e-05 22.6 0.0 0.0001 22.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EFC37033.1 - 0.00053 18.7 0.0 0.00066 18.3 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Abhydrolase_1 PF00561.20 EFC37035.1 - 9e-08 32.1 0.0 1.5e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC37035.1 - 1.1e-06 28.1 0.0 1.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC37035.1 - 0.00058 20.5 0.0 0.00074 20.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family F-box PF00646.33 EFC37036.1 - 0.043 13.7 0.2 0.11 12.5 0.2 1.7 1 0 0 1 1 1 0 F-box domain Borrelia_orfD PF02999.14 EFC37036.1 - 0.3 11.4 10.1 2 8.8 0.5 3.3 2 1 1 3 3 3 0 Borrelia orf-D family F-box PF00646.33 EFC37037.1 - 0.0057 16.5 0.1 0.016 15.1 0.1 1.7 1 0 0 1 1 1 1 F-box domain Vps8 PF12816.7 EFC37038.1 - 7e-15 55.1 3.3 7e-15 55.1 3.3 3.4 3 1 0 3 3 3 2 Golgi CORVET complex core vacuolar protein 8 Cnd1 PF12717.7 EFC37038.1 - 6.2 6.8 11.2 24 4.9 8.2 3.3 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 YbjQ_1 PF01906.17 EFC37039.1 - 0.00078 20.1 7.9 14 6.4 0.0 6.3 4 2 0 6 6 6 1 Putative heavy-metal-binding SAM_KSR1 PF13543.6 EFC37039.1 - 0.049 13.8 10.1 5.7 7.1 0.1 4.8 2 2 3 5 5 5 0 SAM like domain present in kinase suppressor RAS 1 HPPK PF01288.20 EFC37039.1 - 0.061 13.8 0.2 1.9 9.1 0.0 2.9 1 1 1 2 2 2 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) APG17 PF04108.12 EFC37039.1 - 0.063 12.4 10.4 0.24 10.5 10.5 2.0 1 1 0 1 1 1 0 Autophagy protein Apg17 DUF4600 PF15372.6 EFC37039.1 - 1.3 9.5 13.0 4.2 7.8 0.0 4.8 3 1 0 4 4 4 0 Domain of unknown function (DUF4600) Fez1 PF06818.15 EFC37039.1 - 1.4 9.4 13.1 0.16 12.4 4.3 2.7 2 1 1 3 3 3 0 Fez1 HHH_8 PF14716.6 EFC37039.1 - 2.1 8.7 6.9 28 5.2 0.1 4.6 4 0 0 4 4 4 0 Helix-hairpin-helix domain DUF726 PF05277.12 EFC37039.1 - 4.4 6.1 9.5 2.8 6.8 6.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF726) B-block_TFIIIC PF04182.12 EFC37039.1 - 4.6 7.5 7.1 58 4.0 0.1 3.9 4 0 0 4 4 4 0 B-block binding subunit of TFIIIC Rxt3 PF08642.10 EFC37042.1 - 0.74 10.6 6.8 1.8 9.4 2.5 2.8 2 1 1 3 3 3 0 Histone deacetylation protein Rxt3 TPR_1 PF00515.28 EFC37043.1 - 4.2e-92 298.5 55.2 2e-09 36.9 0.8 18.1 17 1 1 18 18 18 17 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37043.1 - 5.9e-83 266.5 43.4 6.6e-06 25.8 1.6 18.1 17 1 1 18 18 18 16 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37043.1 - 4.9e-63 208.6 34.8 1.2e-09 37.7 0.0 16.8 7 4 11 18 18 18 15 TPR repeat TPR_8 PF13181.6 EFC37043.1 - 1e-56 184.5 44.3 0.00026 20.9 0.3 17.4 18 0 0 18 18 17 14 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37043.1 - 5.3e-45 151.8 0.4 9e-07 29.5 0.5 10.0 5 3 6 12 12 12 10 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37043.1 - 3.5e-36 123.3 23.6 5.2e-06 26.7 0.1 12.9 6 2 6 13 13 13 9 Tetratricopeptide repeat TPR_17 PF13431.6 EFC37043.1 - 1.1e-35 119.5 25.8 0.00053 20.2 0.2 14.8 16 1 1 17 17 16 7 Tetratricopeptide repeat TPR_9 PF13371.6 EFC37043.1 - 4.2e-31 106.9 0.7 0.00049 20.2 0.0 11.1 7 2 4 12 12 12 6 Tetratricopeptide repeat TPR_19 PF14559.6 EFC37043.1 - 2.5e-20 72.7 3.8 0.076 13.5 0.1 8.1 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37043.1 - 3.3e-18 65.0 25.9 4.2 8.2 0.2 15.1 16 0 0 16 16 14 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC37043.1 - 5e-16 58.0 5.3 0.22 12.5 0.0 10.8 6 4 7 13 13 13 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC37043.1 - 7.8e-16 58.1 27.5 0.00012 22.2 1.4 8.1 5 1 4 9 9 9 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFC37043.1 - 5e-13 48.1 16.6 1.6 9.0 0.0 12.6 11 2 2 13 13 13 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC37043.1 - 4.1e-12 45.4 25.2 0.4 10.2 0.1 11.5 12 0 0 12 12 12 4 SHNi-TPR TPR_15 PF13429.6 EFC37043.1 - 2.2e-07 30.4 3.9 2.6 7.2 0.0 6.7 5 2 2 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC37043.1 - 2.8e-07 30.2 30.6 0.13 12.2 0.0 12.1 14 2 2 16 16 15 2 Tetratricopeptide repeat Paf67 PF10255.9 EFC37043.1 - 7.6e-07 28.5 9.4 0.0042 16.1 0.0 5.2 2 2 2 5 5 5 2 RNA polymerase I-associated factor PAF67 DUF3856 PF12968.7 EFC37043.1 - 9.2e-05 22.5 9.1 2.1 8.4 0.0 7.1 6 3 2 8 8 7 2 Domain of Unknown Function (DUF3856) TPR_20 PF14561.6 EFC37043.1 - 0.00024 21.4 12.8 1.4 9.3 0.0 6.2 6 2 3 9 9 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC37043.1 - 0.0055 16.1 0.5 0.15 11.4 0.0 3.1 2 1 1 3 3 3 1 MalT-like TPR region BTAD PF03704.17 EFC37043.1 - 0.043 14.2 1.5 32 4.9 0.0 4.6 5 1 0 5 5 5 0 Bacterial transcriptional activator domain NARP1 PF12569.8 EFC37043.1 - 0.11 11.4 27.5 0.45 9.4 9.9 5.1 4 2 0 4 4 4 0 NMDA receptor-regulated protein 1 Fis1_TPR_C PF14853.6 EFC37043.1 - 0.22 11.6 15.5 8.6 6.5 0.3 5.5 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFC37043.1 - 0.24 11.5 23.7 4.4 7.4 0.1 9.9 11 2 2 13 13 12 0 MIT (microtubule interacting and transport) domain Scramblase PF03803.15 EFC37044.1 - 2.7e-49 167.4 0.1 3.5e-49 167.1 0.1 1.1 1 0 0 1 1 1 1 Scramblase Gate PF07670.14 EFC37046.1 - 0.21 11.9 4.4 7.3 6.9 4.4 2.6 1 1 0 1 1 1 0 Nucleoside recognition DUF5056 PF16479.5 EFC37046.1 - 0.66 10.2 5.5 0.97 9.7 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5056) RDD PF06271.12 EFC37046.1 - 2.8 8.1 6.8 0.28 11.4 0.5 2.2 2 0 0 2 2 2 0 RDD family EGF_2 PF07974.13 EFC37047.1 - 1.7e-16 60.3 260.2 0.0014 19.0 12.4 17.6 17 0 0 17 17 17 14 EGF-like domain RGS PF00615.19 EFC37047.1 - 9.2e-05 22.7 0.4 0.00026 21.2 0.4 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4748 PF15932.5 EFC37047.1 - 0.45 10.3 1.6 0.45 10.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) Metallophos PF00149.28 EFC37048.1 - 5.3e-13 49.9 0.2 1.2e-12 48.8 0.3 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC37048.1 - 0.065 13.4 0.0 0.28 11.4 0.0 2.0 3 0 0 3 3 3 0 Calcineurin-like phosphoesterase superfamily domain Pmp3 PF01679.17 EFC37049.1 - 0.2 11.9 12.6 10 6.4 12.6 2.5 1 1 0 1 1 1 0 Proteolipid membrane potential modulator GNT-I PF03071.15 EFC37050.1 - 8e-05 21.6 2.1 0.00029 19.7 2.1 1.8 1 1 0 1 1 1 1 GNT-I family AGT PF11440.8 EFC37050.1 - 0.036 13.1 0.1 0.057 12.5 0.1 1.3 1 0 0 1 1 1 0 DNA alpha-glucosyltransferase ExbD PF02472.16 EFC37050.1 - 0.16 12.2 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR DnaGprimase_HBD PF16730.5 EFC37052.1 - 0.081 13.0 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain F-box PF00646.33 EFC37053.1 - 0.00012 21.9 1.5 0.00065 19.5 0.2 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC37053.1 - 0.00018 21.3 0.0 0.00044 20.1 0.0 1.7 1 0 0 1 1 1 1 F-box-like Gemini_AL1_M PF08283.11 EFC37053.1 - 0.026 14.6 1.3 0.042 13.9 1.3 1.3 1 0 0 1 1 1 0 Geminivirus rep protein central domain Ephrin_rec_like PF07699.13 EFC37054.1 - 6.7e-64 211.5 403.5 3.7e-05 23.4 10.9 26.9 2 1 29 31 31 31 30 Putative ephrin-receptor like RGS PF00615.19 EFC37054.1 - 3.9e-09 36.8 4.5 7.2e-09 35.9 4.5 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Carbam_trans_C PF16861.5 EFC37055.1 - 0.0038 16.8 0.2 0.0038 16.8 0.2 1.8 2 0 0 2 2 2 1 Carbamoyltransferase C-terminus Phospholip_A2_2 PF05826.12 EFC37055.1 - 0.046 13.9 1.1 0.61 10.4 0.3 2.6 2 0 0 2 2 2 0 Phospholipase A2 LisH_TPL PF17814.1 EFC37055.1 - 0.095 12.4 2.1 0.24 11.1 0.1 2.6 2 0 0 2 2 2 0 LisH-like dimerisation domain LicD PF04991.13 EFC37055.1 - 1.9 8.6 8.8 2.9 8.0 8.2 1.6 1 1 0 1 1 1 0 LicD family Peptidase_C39_2 PF13529.6 EFC37056.1 - 0.15 12.6 0.1 0.41 11.2 0.0 1.7 2 0 0 2 2 2 0 Peptidase_C39 like family CAP_C PF08603.11 EFC37057.1 - 2.8e-06 27.1 1.1 4.4e-06 26.4 1.0 1.5 1 1 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EFC37057.1 - 0.0023 17.7 0.3 0.0071 16.1 0.1 1.9 1 1 0 1 1 1 1 Tubulin binding cofactor C Phage_P2_GpE PF06528.12 EFC37057.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 Phage P2 GpE RNA_lig_T4_1 PF09511.10 EFC37058.1 - 3.2e-34 118.7 2.6 3.2e-34 118.7 2.6 1.5 2 0 0 2 2 2 1 RNA ligase Esterase_phd PF10503.9 EFC37059.1 - 1.4e-07 31.3 0.3 8.7e-05 22.1 0.0 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase Stork_head PF10264.9 EFC37059.1 - 0.039 14.1 1.7 4.4 7.6 0.0 2.7 3 0 0 3 3 3 0 Winged helix Storkhead-box1 domain DUF4817 PF16087.5 EFC37059.1 - 0.1 12.4 0.0 2 8.3 0.0 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain (DUF4817) LRR_4 PF12799.7 EFC37060.1 - 2.1e-17 62.9 42.3 7.9e-07 29.3 1.3 9.3 2 2 9 11 11 11 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37060.1 - 3e-17 62.1 34.2 1.2e-08 34.5 4.2 6.3 4 1 2 7 7 7 5 Leucine rich repeat LRR_6 PF13516.6 EFC37060.1 - 6.3e-14 50.8 25.1 0.00091 19.1 0.1 10.0 9 0 0 9 9 9 5 Leucine Rich repeat LRR_9 PF14580.6 EFC37060.1 - 1.4e-05 24.7 14.4 0.00091 18.8 0.4 4.1 2 1 2 4 4 4 3 Leucine-rich repeat F-box-like PF12937.7 EFC37060.1 - 0.0018 18.2 0.0 0.0051 16.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC37060.1 - 0.003 17.9 34.8 0.8 10.5 0.3 10.6 11 1 0 11 11 11 2 Leucine Rich Repeat POC3_POC4 PF10448.9 EFC37060.1 - 0.068 13.2 0.2 0.15 12.1 0.2 1.5 1 0 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 FA_desaturase PF00487.24 EFC37062.1 - 8.4e-08 32.4 18.3 1.6e-07 31.4 18.3 1.4 1 1 0 1 1 1 1 Fatty acid desaturase Nanovirus_C8 PF05629.11 EFC37062.1 - 0.034 14.3 0.2 0.084 13.0 0.2 1.6 1 0 0 1 1 1 0 Nanovirus component 8 (C8) protein ABC_membrane PF00664.23 EFC37063.1 - 1.4e-44 152.9 20.4 2.2e-44 152.1 20.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC37063.1 - 6e-36 124.0 0.0 1.4e-35 122.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC37063.1 - 1.7e-05 24.3 2.3 0.0014 18.2 0.1 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC37063.1 - 0.0012 18.6 0.2 0.003 17.3 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFC37063.1 - 0.0022 17.3 0.0 0.006 15.9 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_15 PF13175.6 EFC37063.1 - 0.0071 16.1 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC37063.1 - 0.0092 16.3 0.1 0.12 12.6 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC37063.1 - 0.021 15.2 0.1 0.095 13.1 0.1 2.2 2 1 1 3 3 3 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFC37063.1 - 0.022 14.7 0.0 0.057 13.3 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 EFC37063.1 - 0.028 14.8 0.2 2.3 8.7 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EFC37063.1 - 0.04 13.6 0.0 0.25 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFC37063.1 - 0.049 12.8 0.0 0.15 11.2 0.0 1.5 1 1 0 1 1 1 0 G-protein alpha subunit DUF87 PF01935.17 EFC37063.1 - 0.055 13.6 0.4 0.2 11.7 0.3 2.0 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_7 PF12775.7 EFC37063.1 - 0.12 11.8 0.0 0.26 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SbcCD_C PF13558.6 EFC37063.1 - 0.16 12.2 0.4 1.4 9.2 0.4 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit E1-E2_ATPase PF00122.20 EFC37063.1 - 0.45 10.0 4.7 12 5.4 0.1 2.8 2 0 0 2 2 2 0 E1-E2 ATPase Ribosomal_S30 PF04758.14 EFC37064.1 - 0.0012 19.0 10.4 0.047 13.9 1.7 2.9 3 0 0 3 3 3 2 Ribosomal protein S30 TF_AP-2 PF03299.14 EFC37064.1 - 0.022 14.7 0.2 0.04 13.9 0.2 1.3 1 0 0 1 1 1 0 Transcription factor AP-2 CDK2AP PF09806.9 EFC37065.1 - 0.073 13.1 3.7 0.087 12.9 3.7 1.3 1 1 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Guanylate_cyc PF00211.20 EFC37066.1 - 1.5e-05 24.7 0.7 3.6e-05 23.5 0.4 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PRP9_N PF16958.5 EFC37066.1 - 0.32 11.0 5.3 0.39 10.7 0.5 2.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus MFS_1 PF07690.16 EFC37067.1 - 1e-32 113.5 55.8 2.5e-26 92.5 28.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EFC37067.1 - 2.3e-25 89.5 9.9 2.3e-25 89.5 9.9 2.5 3 0 0 3 3 3 1 Nodulin-like DUF2678 PF10856.8 EFC37067.1 - 5.4 7.0 11.3 1.4 8.9 0.5 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2678) NHL PF01436.21 EFC37068.1 - 5.6e-06 26.1 0.0 2.1 8.5 0.0 5.3 5 0 0 5 5 5 2 NHL repeat SGL PF08450.12 EFC37068.1 - 3e-05 23.7 0.0 0.32 10.5 0.0 3.4 2 1 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region cEGF PF12662.7 EFC37068.1 - 0.47 10.4 6.3 0.18 11.8 2.4 2.4 2 0 0 2 2 2 0 Complement Clr-like EGF-like FtsJ PF01728.19 EFC37069.1 - 2.4e-70 236.2 0.1 3e-70 235.9 0.1 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase E1-N PF14463.6 EFC37069.1 - 0.21 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 E1 N-terminal domain EcsC PF12787.7 EFC37071.1 - 0.034 13.8 0.3 0.86 9.2 1.3 2.8 2 1 1 3 3 3 0 EcsC protein family AdoHcyase PF05221.17 EFC37073.1 - 1.7e-140 467.4 0.0 1.9e-140 467.2 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 EFC37073.1 - 1.1e-81 272.7 4.2 1.6e-81 272.1 4.2 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFC37073.1 - 7.9e-10 38.4 0.1 1.4e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EFC37073.1 - 3.8e-05 24.1 0.4 0.00011 22.6 0.4 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding IlvN PF07991.12 EFC37073.1 - 0.0001 21.9 0.1 0.00018 21.1 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.19 EFC37073.1 - 0.00031 20.1 1.3 0.0013 18.1 1.3 1.9 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 EFC37073.1 - 0.00055 20.0 0.1 0.0012 18.9 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EFC37073.1 - 0.0026 18.0 1.7 0.0057 16.9 0.4 2.3 2 1 0 2 2 2 1 TrkA-N domain ELFV_dehydrog PF00208.21 EFC37073.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Retrotran_gag_2 PF14223.6 EFC37075.1 - 0.04 13.6 1.8 0.094 12.4 0.5 2.0 1 1 1 2 2 2 0 gag-polypeptide of LTR copia-type CENP-F_leu_zip PF10473.9 EFC37076.1 - 0.0029 17.6 3.6 0.01 15.8 3.6 1.8 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TolA_bind_tri PF16331.5 EFC37076.1 - 0.013 15.6 5.0 0.64 10.1 0.6 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Herpes_UL14 PF03580.14 EFC37076.1 - 0.013 15.7 1.6 0.33 11.2 0.3 2.1 2 0 0 2 2 2 0 Herpesvirus UL14-like protein NPV_P10 PF05531.12 EFC37076.1 - 0.019 15.4 0.3 4.9 7.7 0.0 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Snf7 PF03357.21 EFC37076.1 - 0.022 14.4 2.6 0.035 13.7 2.6 1.3 1 0 0 1 1 1 0 Snf7 DUF1664 PF07889.12 EFC37076.1 - 0.059 13.4 2.3 0.23 11.5 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HU-CCDC81_bac_2 PF18175.1 EFC37076.1 - 0.062 13.2 0.8 30 4.6 0.1 3.3 2 1 1 3 3 3 0 CCDC81-like prokaryotic HU domain 2 TMF_DNA_bd PF12329.8 EFC37076.1 - 0.086 12.9 3.6 1.9 8.6 1.3 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FPP PF05911.11 EFC37076.1 - 0.1 10.7 2.8 0.13 10.5 2.8 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil RPW8 PF05659.11 EFC37076.1 - 0.12 12.0 2.9 0.17 11.6 1.4 1.9 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 APG6_N PF17675.1 EFC37076.1 - 0.16 12.5 6.5 0.065 13.8 2.9 1.9 1 1 1 2 2 2 0 Apg6 coiled-coil region SlyX PF04102.12 EFC37076.1 - 0.39 11.4 4.2 1.5 9.5 1.8 2.4 1 1 1 2 2 2 0 SlyX LptF_LptG PF03739.14 EFC37076.1 - 2.1 7.1 4.2 2.4 6.9 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG Cpn60_TCP1 PF00118.24 EFC37077.1 - 1e-167 558.7 7.7 1.1e-167 558.5 7.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family AbbA_antirepres PF14156.6 EFC37077.1 - 0.0068 16.3 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 Antirepressor AbbA LepB_N PF18640.1 EFC37077.1 - 0.058 13.0 0.4 0.84 9.2 0.0 2.7 3 0 0 3 3 3 0 LepB N-terminal domain DLIC PF05783.11 EFC37079.1 - 4.9e-19 68.5 2.0 2.8e-17 62.7 2.0 2.1 1 1 0 1 1 1 1 Dynein light intermediate chain (DLIC) Roc PF08477.13 EFC37079.1 - 0.0082 16.4 0.5 0.039 14.2 0.5 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFC37079.1 - 0.082 12.6 0.4 1.6 8.4 0.0 2.7 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Cauli_DNA-bind PF03310.13 EFC37079.1 - 0.16 12.0 3.8 0.58 10.2 0.5 2.3 1 1 1 2 2 2 0 Caulimovirus DNA-binding protein Ribosomal_L7Ae PF01248.26 EFC37080.1 - 9.1e-14 51.0 0.2 1.2e-13 50.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF577 PF04510.12 EFC37080.1 - 0.057 13.3 0.0 0.085 12.8 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF577) DNA_photolyase PF00875.18 EFC37080.1 - 0.071 13.1 0.0 0.099 12.6 0.0 1.2 1 0 0 1 1 1 0 DNA photolyase Ribosomal_S6 PF01250.17 EFC37080.1 - 0.091 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S6 NARG2_C PF10505.9 EFC37082.1 - 1e-13 51.3 2.4 1.1e-12 47.9 0.2 2.5 2 0 0 2 2 2 1 NMDA receptor-regulated gene protein 2 C-terminus eIF-5_eIF-2B PF01873.17 EFC37082.1 - 0.0013 18.6 6.0 0.0019 18.1 0.3 3.3 1 1 2 3 3 3 1 Domain found in IF2B/IF5 NUDIX PF00293.28 EFC37082.1 - 0.032 14.3 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 NUDIX domain CpXC PF14353.6 EFC37082.1 - 0.056 13.5 1.9 3.5 7.7 0.2 3.2 1 1 1 2 2 2 0 CpXC protein SAM_KSR1 PF13543.6 EFC37082.1 - 0.07 13.3 4.1 0.046 13.9 0.6 2.7 3 0 0 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 bVLRF1 PF18826.1 EFC37083.1 - 1.1e-27 96.7 0.3 2.7e-27 95.5 0.3 1.6 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor F-box-like PF12937.7 EFC37083.1 - 0.018 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 F-box-like Glyco_transf_4 PF13439.6 EFC37083.1 - 0.15 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 NmrA PF05368.13 EFC37084.1 - 2.1e-32 112.5 0.0 2.9e-32 112.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC37084.1 - 0.00011 22.2 0.0 0.00019 21.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding LRR_2 PF07723.13 EFC37086.1 - 0.027 15.1 0.0 21 6.0 0.0 3.0 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_4 PF12799.7 EFC37086.1 - 0.33 11.5 0.1 0.33 11.5 0.1 4.0 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF1173 PF06666.11 EFC37087.1 - 0.2 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) SR-25 PF10500.9 EFC37087.1 - 5 6.7 12.7 12 5.4 12.7 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LRR_6 PF13516.6 EFC37088.1 - 2e-28 96.0 62.4 6.3e-05 22.7 0.1 16.5 17 0 0 17 17 17 11 Leucine Rich repeat LRR_4 PF12799.7 EFC37088.1 - 1.5e-14 53.9 86.6 0.00088 19.6 0.3 11.7 4 2 8 12 12 12 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37088.1 - 1.5e-12 47.1 66.5 0.019 14.7 2.6 9.6 8 2 1 9 9 9 7 Leucine rich repeat LRR_1 PF00560.33 EFC37088.1 - 2e-05 24.5 51.7 3.5 8.5 0.2 13.8 15 2 1 16 16 16 4 Leucine Rich Repeat LRR_2 PF07723.13 EFC37088.1 - 0.0067 17.1 0.8 31 5.5 0.0 5.1 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC37088.1 - 0.38 10.2 26.5 1.5 8.3 0.5 5.2 1 1 4 6 6 6 0 Leucine-rich repeat NHL PF01436.21 EFC37089.1 - 9.4e-12 44.3 8.4 0.007 16.3 0.0 7.3 7 1 0 7 7 7 3 NHL repeat DUF4934 PF16288.5 EFC37089.1 - 0.0063 16.4 0.1 0.85 9.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4934) Peptidase_C26 PF07722.13 EFC37090.1 - 6e-11 42.5 0.0 1.2e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 EFC37090.1 - 1.3e-05 25.1 0.0 3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I BTV_NS2 PF04514.12 EFC37090.1 - 0.016 14.1 0.0 0.024 13.5 0.0 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 Cytochrom_C1 PF02167.15 EFC37090.1 - 0.032 14.0 0.3 0.048 13.4 0.3 1.2 1 0 0 1 1 1 0 Cytochrome C1 family Hydrolase_4 PF12146.8 EFC37091.1 - 6.8e-15 55.0 0.0 3e-12 46.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC37091.1 - 1.2e-13 51.4 0.3 4.3e-13 49.5 0.2 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC37091.1 - 1.2e-07 32.6 0.0 1.6e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFC37091.1 - 3e-07 30.1 0.6 0.007 15.9 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Peptidase_S28 PF05577.12 EFC37091.1 - 0.028 13.2 0.0 0.042 12.6 0.0 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 BAAT_C PF08840.11 EFC37091.1 - 0.08 12.8 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 EFC37091.1 - 0.1 11.9 0.6 0.34 10.2 0.0 2.1 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.18 EFC37091.1 - 0.11 12.1 0.0 0.31 10.5 0.0 1.7 2 0 0 2 2 2 0 Dienelactone hydrolase family RCC1 PF00415.18 EFC37092.1 - 1.2e-09 38.7 0.1 0.081 13.6 0.0 4.2 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37092.1 - 4.3e-08 32.8 0.4 2.3e-05 24.1 0.0 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat WD40 PF00400.32 EFC37093.1 - 2.8e-23 81.7 8.6 0.00011 22.9 0.0 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat Sof1 PF04158.14 EFC37093.1 - 3e-17 62.6 13.5 7e-17 61.5 13.5 1.6 1 0 0 1 1 1 1 Sof1-like domain eIF2A PF08662.11 EFC37093.1 - 2.8e-05 24.1 0.1 0.00075 19.4 0.2 2.7 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 EFC37093.1 - 3.1e-05 24.0 0.2 8.9 6.4 0.0 4.5 3 2 2 5 5 5 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EFC37093.1 - 3.3e-05 24.1 0.1 1.1 9.6 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC37093.1 - 0.00045 19.6 0.3 0.13 11.6 0.0 3.4 4 0 0 4 4 4 1 WD40-like domain Nup160 PF11715.8 EFC37093.1 - 0.046 12.4 0.2 4.9 5.7 0.0 2.6 3 1 0 3 3 3 0 Nucleoporin Nup120/160 Spt5_N PF11942.8 EFC37093.1 - 1 10.4 7.6 2.8 9.0 7.6 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Tab2_like PF06485.11 EFC37094.1 - 0.012 15.1 0.0 0.015 14.8 0.0 1.1 1 0 0 1 1 1 0 RNA-binding protein Tab2/Atab2 PWI PF01480.17 EFC37095.1 - 3e-22 78.7 1.0 4.7e-22 78.1 1.0 1.3 1 0 0 1 1 1 1 PWI domain FA_desaturase PF00487.24 EFC37096.1 - 4.6e-09 36.5 10.9 8.2e-09 35.7 10.9 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Nanovirus_C8 PF05629.11 EFC37096.1 - 0.22 11.6 1.0 0.41 10.8 0.5 1.6 2 0 0 2 2 2 0 Nanovirus component 8 (C8) protein Ank_2 PF12796.7 EFC37097.1 - 1.8e-28 98.9 0.2 8.8e-11 42.3 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC37097.1 - 2.8e-19 69.2 0.3 4.5e-06 27.1 0.0 4.7 4 2 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC37097.1 - 1e-18 65.5 1.4 0.01 16.3 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 EFC37097.1 - 7.8e-17 60.9 0.2 0.023 15.1 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFC37097.1 - 1.7e-14 53.7 0.3 0.0031 17.8 0.0 5.1 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Dip PF17679.1 EFC37097.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 gp37/Dip protein DUF3447 PF11929.8 EFC37097.1 - 2.1 8.4 6.1 2 8.5 0.4 3.3 2 2 2 4 4 4 0 Domain of unknown function (DUF3447) DUF4957 PF16318.5 EFC37098.1 - 0.033 14.1 0.3 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4957) LRR_6 PF13516.6 EFC37100.1 - 3.7e-24 82.7 10.7 1.4e-05 24.7 0.0 6.5 6 1 0 6 6 6 5 Leucine Rich repeat LRR_8 PF13855.6 EFC37100.1 - 6.1e-16 57.9 9.0 2.5e-06 27.1 0.3 3.4 3 0 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC37100.1 - 1.7e-12 47.3 19.8 0.00071 19.9 7.6 5.2 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37100.1 - 3.7e-05 23.7 10.0 5.1 8.0 0.0 6.2 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC37100.1 - 0.00013 21.6 2.3 0.16 11.5 0.0 2.7 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 EFC37101.1 - 1.5e-16 59.0 0.2 0.00016 21.5 0.0 4.1 4 0 0 4 4 4 3 Leucine Rich repeat LRR_8 PF13855.6 EFC37101.1 - 5.1e-12 45.4 1.7 1.6e-07 31.0 0.1 2.8 2 1 1 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EFC37101.1 - 5.5e-08 33.0 3.5 9.5e-05 22.7 0.0 3.4 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37101.1 - 1.7e-05 24.7 1.5 1.2 10.0 0.0 4.7 3 2 0 3 3 3 1 Leucine Rich Repeat FTH PF01827.27 EFC37101.1 - 0.0033 17.2 2.5 0.0099 15.7 1.9 1.8 1 1 1 2 2 2 1 FTH domain bMG10 PF17973.1 EFC37102.1 - 4.5e-30 104.5 0.0 1.1e-29 103.2 0.0 1.7 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_BRD PF07703.14 EFC37102.1 - 3.9e-15 56.4 0.5 3.9e-15 56.4 0.5 3.1 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain MG2 PF01835.19 EFC37102.1 - 2.4e-13 50.4 0.0 1.2e-10 41.7 0.0 4.1 3 0 0 3 3 3 1 MG2 domain A2M PF00207.22 EFC37102.1 - 1.3e-11 44.2 0.0 6.6e-11 41.9 0.0 2.3 2 0 0 2 2 2 1 Alpha-2-macroglobulin family Big_5 PF13205.6 EFC37102.1 - 3.4e-07 30.9 3.7 0.07 13.8 0.0 4.2 3 0 0 3 3 3 2 Bacterial Ig-like domain bMG3 PF11974.8 EFC37102.1 - 0.0024 17.9 3.6 0.028 14.5 0.0 3.9 4 0 0 4 4 4 1 Bacterial alpha-2-macroglobulin MG3 domain ZirS_C PF16583.5 EFC37102.1 - 0.016 14.8 1.3 0.063 12.8 0.5 2.2 2 0 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain DUF11 PF01345.18 EFC37102.1 - 0.027 14.7 1.8 0.14 12.5 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF11 PurA PF04845.13 EFC37102.1 - 0.049 12.9 0.2 0.33 10.3 0.1 2.3 2 0 0 2 2 2 0 PurA ssDNA and RNA-binding protein MG4 PF17789.1 EFC37102.1 - 0.14 12.4 6.0 13 6.0 0.0 5.1 4 1 1 5 5 5 0 Macroglobulin domain MG4 DUF4198 PF10670.9 EFC37102.1 - 0.15 12.4 0.3 1 9.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4198) CarboxypepD_reg PF13620.6 EFC37102.1 - 0.17 12.2 4.0 1.6 9.1 0.5 3.5 3 0 0 3 3 3 0 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 EFC37102.1 - 0.31 11.1 10.5 0.64 10.1 0.1 5.2 6 0 0 6 6 5 0 Bacterial Ig-like domain (group 1) Aldedh PF00171.22 EFC37103.1 - 1.3e-81 274.5 0.0 1.8e-81 274.0 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Myb_DNA-binding PF00249.31 EFC37104.1 - 4.5e-05 23.5 0.0 7.9e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain ATP11 PF06644.11 EFC37104.1 - 0.0057 16.5 4.1 0.0057 16.5 4.1 3.4 4 0 0 4 4 4 1 ATP11 protein TM2 PF05154.16 EFC37105.1 - 4.3e-13 49.4 10.0 6.2e-13 48.9 10.0 1.2 1 0 0 1 1 1 1 TM2 domain Rib_recp_KP_reg PF05104.12 EFC37105.1 - 0.13 13.3 2.0 0.17 12.9 2.0 1.1 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Chromo PF00385.24 EFC37107.1 - 2.9e-10 39.9 0.1 6.1e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain WD40 PF00400.32 EFC37108.1 - 7.3e-28 96.2 15.1 4e-09 37.0 0.7 6.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC37108.1 - 2.8e-19 69.2 9.1 1.1e-07 32.1 1.2 5.3 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC37108.1 - 0.0069 15.4 0.3 0.18 10.8 0.0 2.8 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC37108.1 - 0.01 15.2 0.0 0.092 12.0 0.1 2.1 2 0 0 2 2 2 0 WD40-like domain Kinesin PF00225.23 EFC37109.1 - 2e-80 270.2 3.9 2e-80 270.2 3.9 2.7 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC37109.1 - 2.5e-32 111.9 0.2 2.5e-32 111.9 0.2 3.2 3 0 0 3 3 3 1 Microtubule binding AAA_22 PF13401.6 EFC37109.1 - 0.0034 17.7 0.1 0.047 14.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain T3SSipB PF16535.5 EFC37109.1 - 0.017 15.6 6.4 0.16 12.4 4.1 2.6 2 0 0 2 2 2 0 Type III cell invasion protein SipB AAA_16 PF13191.6 EFC37109.1 - 0.099 13.0 0.0 0.65 10.4 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain PIN_5 PF08745.11 EFC37109.1 - 0.22 10.9 3.8 0.082 12.3 0.5 1.9 2 0 0 2 2 2 0 PINc domain ribonuclease ABC_tran_CTD PF16326.5 EFC37109.1 - 0.47 10.7 6.8 8.5 6.7 3.0 2.9 2 0 0 2 2 2 0 ABC transporter C-terminal domain DivIC PF04977.15 EFC37109.1 - 4.4 7.1 8.4 4 7.3 5.5 2.5 1 1 1 2 2 2 0 Septum formation initiator LRR_6 PF13516.6 EFC37110.1 - 2.5e-13 48.9 26.8 0.034 14.2 0.4 8.0 8 0 0 8 8 8 5 Leucine Rich repeat LRR_8 PF13855.6 EFC37110.1 - 1.3e-09 37.7 27.1 0.0073 16.1 0.4 5.1 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC37110.1 - 3.3e-09 36.9 44.4 0.0049 17.2 2.5 6.9 2 2 4 7 7 7 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC37110.1 - 7.9e-05 22.5 0.1 0.00018 21.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like DUF3744 PF12558.8 EFC37110.1 - 0.013 16.2 4.5 2.3 9.1 0.2 3.8 2 1 1 3 3 3 0 ATP-binding cassette cobalt transporter LRR_9 PF14580.6 EFC37110.1 - 0.021 14.4 11.5 0.33 10.4 2.2 2.6 1 1 1 2 2 2 0 Leucine-rich repeat DUF1251 PF06856.11 EFC37110.1 - 0.11 12.2 0.4 1.2 8.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1251) F-box PF00646.33 EFC37110.1 - 0.34 10.8 5.0 1.6 8.7 2.7 3.2 2 1 0 2 2 2 0 F-box domain LRR_1 PF00560.33 EFC37110.1 - 0.56 11.0 28.5 26 5.9 0.1 8.9 9 2 0 9 9 9 0 Leucine Rich Repeat LRR_2 PF07723.13 EFC37110.1 - 3.8 8.3 0.0 3.8 8.3 0.0 6.3 8 2 2 10 10 10 0 Leucine Rich Repeat Stimulus_sens_1 PF13756.6 EFC37113.1 - 0.26 11.9 0.0 0.42 11.2 0.0 1.2 1 0 0 1 1 1 0 Stimulus-sensing domain RCC1 PF00415.18 EFC37114.1 - 1.3e-15 57.7 24.6 0.00014 22.4 0.0 9.3 9 1 0 9 9 9 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37114.1 - 7.1e-13 48.0 29.0 0.012 15.4 0.3 9.1 10 0 0 10 10 10 5 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 EFC37114.1 - 4.1e-06 26.6 0.0 1.2e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 F-box-like EGF_2 PF07974.13 EFC37114.1 - 0.0059 16.9 9.2 0.014 15.7 9.2 1.6 1 0 0 1 1 1 1 EGF-like domain Ras PF00071.22 EFC37116.1 - 3.2e-06 26.8 0.1 0.00022 20.8 0.0 2.5 1 1 1 2 2 2 1 Ras family BTB PF00651.31 EFC37116.1 - 0.00014 22.1 0.5 0.00037 20.7 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain Adenine_glyco PF03352.13 EFC37116.1 - 0.13 12.0 0.3 0.25 11.1 0.3 1.4 1 0 0 1 1 1 0 Methyladenine glycosylase CEL_III_C PF18054.1 EFC37116.1 - 0.21 11.7 1.0 0.4 10.7 0.1 1.8 2 0 0 2 2 2 0 CEL-III C-terminal Trypan_PARP PF05887.11 EFC37117.1 - 0.0032 17.4 78.4 0.2 11.6 36.3 2.3 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Peptidase_C2 PF00648.21 EFC37118.1 - 1.6e-35 122.6 7.6 1.2e-21 77.0 0.0 4.0 3 1 0 3 3 3 3 Calpain family cysteine protease SQS_PSY PF00494.19 EFC37119.1 - 6.6e-32 111.0 0.0 1.1e-31 110.3 0.0 1.3 1 1 0 1 1 1 1 Squalene/phytoene synthase Thioredoxin PF00085.20 EFC37120.1 - 2.4e-21 75.7 1.8 2.6e-20 72.3 0.1 3.0 2 1 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.6 EFC37120.1 - 0.00014 22.0 0.2 0.00076 19.6 0.1 2.3 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 EFC37120.1 - 0.0019 18.5 2.5 0.5 10.7 0.1 3.8 2 2 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFC37120.1 - 0.0028 18.1 0.2 0.1 13.0 0.2 2.8 1 1 0 1 1 1 1 Thioredoxin-like domain Fib_alpha PF08702.10 EFC37120.1 - 0.04 14.1 0.2 0.2 11.8 0.0 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family YugN PF08868.10 EFC37120.1 - 0.091 12.7 0.1 3.2 7.7 0.0 2.5 2 0 0 2 2 2 0 YugN-like family GyrI-like PF06445.15 EFC37121.1 - 2.3e-13 50.7 0.1 6.3e-13 49.3 0.1 1.7 1 1 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 EFC37121.1 - 0.00013 22.2 0.2 0.0041 17.3 0.2 2.1 1 1 0 1 1 1 1 Integron-associated effector binding protein TFIIB PF00382.19 EFC37123.1 - 3.8e-11 42.9 0.8 3.6e-05 23.7 0.3 3.7 3 1 1 4 4 4 2 Transcription factor TFIIB repeat HTH_IclR PF09339.10 EFC37123.1 - 0.047 13.5 0.4 0.11 12.3 0.4 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain DZR PF12773.7 EFC37123.1 - 0.13 12.3 1.2 0.27 11.3 1.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon ArfGap PF01412.18 EFC37123.1 - 0.3 11.2 4.3 9.6 6.3 1.4 2.7 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.12 EFC37123.1 - 0.33 10.5 3.3 0.18 11.4 0.7 2.0 2 0 0 2 2 2 0 TFIIB zinc-binding zf-ribbon_3 PF13248.6 EFC37123.1 - 1.2 8.6 4.2 3.9 7.0 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 EFC37123.1 - 1.5 8.6 4.1 8.1 6.3 0.2 2.3 1 1 1 2 2 2 0 zinc-ribbon domain AT_hook PF02178.19 EFC37125.1 - 0.0039 16.9 21.6 0.34 10.9 6.8 3.0 2 0 0 2 2 2 2 AT hook motif RBR PF17208.3 EFC37125.1 - 6.5 7.5 15.2 2 9.2 3.5 3.3 3 0 0 3 3 3 0 RNA binding Region Ank_4 PF13637.6 EFC37127.1 - 2.1e-22 79.2 0.3 2.4e-14 53.5 0.0 2.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC37127.1 - 1.3e-17 64.1 0.0 1.8e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC37127.1 - 5.1e-16 58.5 0.0 2.7e-07 30.7 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC37127.1 - 6e-09 36.0 0.0 0.0076 16.7 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFC37127.1 - 9.9e-09 34.8 0.0 0.00078 19.7 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat UCH PF00443.29 EFC37128.1 - 5.3e-40 137.5 7.1 1.1e-39 136.5 7.1 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC37128.1 - 7.7e-11 42.1 7.5 7.7e-11 42.1 7.5 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TSNAXIP1_N PF15739.5 EFC37128.1 - 0.011 16.1 3.3 0.055 13.9 3.3 2.3 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus VASP_tetra PF08776.11 EFC37128.1 - 0.024 14.2 1.0 1.2 8.8 0.3 3.4 3 0 0 3 3 3 0 VASP tetramerisation domain Baculo_PEP_C PF04513.12 EFC37128.1 - 2.3 8.3 7.9 5.9 6.9 0.3 3.6 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 EFC37128.1 - 4.2 7.4 10.5 20 5.3 8.8 2.9 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein SPATA24 PF15175.6 EFC37129.1 - 0.089 12.7 0.4 0.11 12.3 0.4 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 24 GABP-alpha PF11620.8 EFC37129.1 - 0.14 12.3 0.7 3.1 8.1 0.1 2.2 1 1 1 2 2 2 0 GA-binding protein alpha chain Adaptin_N PF01602.20 EFC37130.1 - 5.4e-95 318.9 12.7 8.6e-95 318.3 12.7 1.3 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 EFC37130.1 - 4.2e-38 130.8 4.8 1.2e-37 129.3 4.8 1.9 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 EFC37130.1 - 4.1e-22 78.5 0.3 1.3e-21 76.9 0.0 2.1 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 EFC37130.1 - 6.3e-15 55.3 0.1 0.00011 22.5 0.0 4.9 3 2 1 4 4 4 4 HEAT repeats Cnd1 PF12717.7 EFC37130.1 - 6.3e-12 45.8 12.0 0.00039 20.5 0.2 4.3 3 1 1 4 4 4 3 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EFC37130.1 - 0.0025 17.9 0.0 0.0067 16.5 0.0 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 EFC37130.1 - 0.012 15.8 1.1 58 4.3 0.1 5.2 5 0 0 5 5 5 0 HEAT repeat TAF6_C PF07571.13 EFC37130.1 - 0.035 14.4 0.1 12 6.3 0.1 3.1 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain HEAT_EZ PF13513.6 EFC37130.1 - 0.13 12.8 2.2 18 6.0 0.3 4.4 2 2 3 5 5 5 0 HEAT-like repeat eIF2A PF08662.11 EFC37131.1 - 3.6e-32 111.8 2.0 9.1e-29 100.7 0.4 3.6 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 EFC37131.1 - 0.00021 21.0 0.2 0.00065 19.5 0.2 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TF_AP-2 PF03299.14 EFC37131.1 - 0.028 14.4 1.9 0.037 14.0 1.0 1.7 2 0 0 2 2 2 0 Transcription factor AP-2 WD40 PF00400.32 EFC37131.1 - 0.092 13.7 1.0 48 5.0 0.1 4.0 4 0 0 4 4 4 0 WD domain, G-beta repeat YqeY PF09424.10 EFC37131.1 - 0.11 12.5 10.4 0.38 10.8 5.9 2.5 2 0 0 2 2 2 0 Yqey-like protein Androgen_recep PF02166.16 EFC37132.1 - 2.5 6.8 5.9 3.8 6.2 5.9 1.2 1 0 0 1 1 1 0 Androgen receptor ISG65-75 PF11727.8 EFC37133.1 - 0.029 13.6 0.1 0.03 13.6 0.1 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein NuiA PF07924.11 EFC37133.1 - 0.049 14.0 2.0 0.44 11.0 2.0 2.0 1 1 0 1 1 1 0 Nuclease A inhibitor-like protein PDDEXK_6 PF04720.12 EFC37133.1 - 0.06 13.3 0.2 0.062 13.2 0.2 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function SAP30_Sin3_bdg PF13867.6 EFC37133.1 - 0.098 13.0 0.0 0.23 11.8 0.0 1.7 1 1 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Vps53_N PF04100.12 EFC37134.1 - 3.9e-100 335.5 8.5 3.9e-100 335.5 8.5 2.6 3 1 0 3 3 3 1 Vps53-like, N-terminal Vps54_N PF10475.9 EFC37134.1 - 2.9e-08 33.4 8.8 2.9e-08 33.4 8.8 2.4 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex COG5 PF10392.9 EFC37134.1 - 0.016 15.4 2.3 0.016 15.4 2.3 2.9 3 0 0 3 3 3 0 Golgi transport complex subunit 5 DUF2110 PF09883.9 EFC37134.1 - 0.1 12.2 2.8 6.2 6.3 0.8 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) V-SNARE_C PF12352.8 EFC37134.1 - 0.25 11.7 9.4 1.3 9.3 1.1 4.1 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus DUF2570 PF10828.8 EFC37134.1 - 0.71 9.7 15.0 1.6 8.6 2.3 4.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2570) FUSC PF04632.12 EFC37134.1 - 1.2 7.5 2.2 0.72 8.3 0.4 1.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family PAH PF02671.21 EFC37134.1 - 2.8 8.2 6.4 19 5.5 0.0 4.7 5 0 0 5 5 5 0 Paired amphipathic helix repeat DUF489 PF04356.12 EFC37134.1 - 3.4 7.6 18.3 0.63 10.0 0.3 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF489) GTP_EFTU PF00009.27 EFC37134.1 - 6.1 6.3 7.0 2 7.9 0.1 2.8 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Goodbye PF17109.5 EFC37134.1 - 6.9 7.1 7.0 40 4.7 1.7 4.5 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF1539 PF07560.11 EFC37134.1 - 9.6 6.3 9.2 1.1 9.4 0.4 3.9 5 0 0 5 5 5 0 Domain of Unknown Function (DUF1539) Pkinase_Tyr PF07714.17 EFC37135.1 - 1.5e-49 168.7 0.0 4.5e-45 153.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC37135.1 - 1.6e-48 165.4 0.0 2.5e-48 164.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC37135.1 - 0.00051 18.9 0.1 0.00068 18.5 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC37135.1 - 0.0059 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EFC37135.1 - 0.09 12.0 0.0 8.8 5.4 0.0 2.3 1 1 1 2 2 2 0 Fructosamine kinase PARP PF00644.20 EFC37136.1 - 1.3e-12 47.7 5.2 1.7e-12 47.4 1.8 2.5 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain ART-PolyVal PF18760.1 EFC37136.1 - 0.061 14.4 0.6 0.9 10.6 0.0 2.7 2 1 1 3 3 3 0 ADP-Ribosyltransferase in polyvalent proteins SIR2 PF02146.17 EFC37136.1 - 0.078 12.9 0.8 1 9.3 0.5 2.5 1 1 1 2 2 2 0 Sir2 family ERM PF00769.19 EFC37136.1 - 0.41 10.4 4.7 0.86 9.4 4.7 1.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family ABC_membrane PF00664.23 EFC37137.1 - 5.6e-57 193.5 14.4 8.4e-57 192.9 14.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC37137.1 - 4.5e-36 124.4 0.4 9.1e-36 123.4 0.0 1.8 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EFC37137.1 - 3.3e-07 30.0 0.2 0.00025 20.6 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC37137.1 - 0.00066 19.4 0.0 0.0015 18.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFC37137.1 - 0.0008 19.7 0.0 0.002 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC37137.1 - 0.0022 18.4 0.3 0.0097 16.3 0.3 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EFC37137.1 - 0.0035 17.1 7.2 0.0097 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EFC37137.1 - 0.0047 16.7 0.0 0.027 14.2 0.0 2.2 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFC37137.1 - 0.015 15.2 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase DUF1764 PF08576.10 EFC37137.1 - 0.042 14.7 4.2 0.09 13.7 4.2 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) AAA_5 PF07728.14 EFC37137.1 - 0.045 13.7 0.0 0.24 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EFC37137.1 - 0.078 11.8 0.1 0.26 10.1 0.0 1.8 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_18 PF13238.6 EFC37137.1 - 0.13 12.8 0.2 0.37 11.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EFC37137.1 - 0.16 12.2 0.2 0.98 9.7 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Kelch_4 PF13418.6 EFC37138.1 - 4.7e-06 26.5 0.1 0.038 14.0 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC37138.1 - 4.9e-06 26.4 0.0 1.6e-05 24.8 0.0 2.0 1 0 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 EFC37138.1 - 0.00037 20.7 0.0 0.059 13.7 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC37138.1 - 0.006 16.8 0.4 0.044 14.1 0.0 2.6 3 0 0 3 3 3 1 Kelch motif CDC48_2 PF02933.17 EFC37138.1 - 0.014 15.2 0.0 0.12 12.2 0.1 2.4 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 RCC1_2 PF13540.6 EFC37139.1 - 0.041 13.7 2.2 0.061 13.2 0.0 2.5 4 0 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat ADH_N_2 PF16884.5 EFC37140.1 - 2e-18 66.3 0.1 1.3e-08 34.7 0.1 2.3 1 1 1 2 2 2 2 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFC37140.1 - 1.9e-13 50.5 0.0 3.2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC37140.1 - 1.3e-08 36.0 0.0 5.5e-08 33.9 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFC37140.1 - 0.00046 19.7 0.3 0.00071 19.1 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Arf PF00025.21 EFC37141.1 - 2.7e-45 153.9 0.3 3.7e-45 153.5 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC37141.1 - 2.9e-14 52.9 0.1 3.5e-14 52.6 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC37141.1 - 2.3e-13 50.4 0.1 3.8e-13 49.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC37141.1 - 6.2e-12 45.4 0.0 8.9e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC37141.1 - 1.4e-09 37.6 1.8 9.3e-08 31.6 0.5 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC37141.1 - 2.4e-08 33.6 0.1 3.2e-08 33.2 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC37141.1 - 5.7e-08 32.8 0.0 1.1e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EFC37141.1 - 0.00035 20.5 0.1 0.00056 19.9 0.1 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 EFC37141.1 - 0.00074 19.8 0.1 0.0017 18.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 EFC37141.1 - 0.0013 18.4 0.3 0.34 10.5 0.0 2.2 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFC37141.1 - 0.0072 16.2 0.3 1.1 9.2 0.1 2.7 1 1 2 3 3 3 1 RsgA GTPase Thymidylate_kin PF02223.17 EFC37141.1 - 0.0082 15.8 0.5 0.039 13.6 0.0 2.1 2 0 0 2 2 2 1 Thymidylate kinase ATP_bind_1 PF03029.17 EFC37141.1 - 0.024 14.4 0.3 2.5 7.8 0.0 2.3 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 EFC37141.1 - 0.042 14.3 0.0 0.072 13.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFC37141.1 - 0.06 13.9 0.1 0.097 13.2 0.1 1.4 1 1 0 1 1 1 0 ABC transporter VWA PF00092.28 EFC37141.1 - 0.11 12.7 1.4 0.15 12.3 0.1 1.9 3 0 0 3 3 3 0 von Willebrand factor type A domain T4_Rnl2_C PF18043.1 EFC37142.1 - 5.9e-28 96.8 0.7 5.9e-28 96.8 0.7 2.0 2 0 0 2 2 2 1 T4 RNA ligase 2 C-terminal RNA_ligase PF09414.10 EFC37142.1 - 6.5e-18 65.5 0.0 1.7e-17 64.2 0.0 1.7 1 1 0 1 1 1 1 RNA ligase DUF4268 PF14088.6 EFC37142.1 - 0.0031 17.4 0.6 0.0083 16.0 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4268) LRR_8 PF13855.6 EFC37143.1 - 6.3e-05 22.7 4.4 6.3e-05 22.7 4.4 4.0 3 1 1 4 4 4 1 Leucine rich repeat LRR_4 PF12799.7 EFC37143.1 - 0.00027 21.3 5.6 0.00027 21.3 5.6 4.9 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC37143.1 - 0.02 14.9 6.3 2.2 8.6 0.9 4.3 4 0 0 4 4 4 0 Leucine Rich repeat RCC1_2 PF13540.6 EFC37144.1 - 1.1e-06 28.2 0.1 0.00032 20.4 0.0 3.4 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37144.1 - 0.00051 20.6 0.1 0.73 10.5 0.0 2.8 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat BAH PF01426.18 EFC37144.1 - 0.021 14.7 0.0 0.061 13.2 0.0 1.8 1 0 0 1 1 1 0 BAH domain Ras PF00071.22 EFC37145.1 - 5.2e-17 61.9 0.0 8.8e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37145.1 - 1.4e-11 44.7 0.0 3.4e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF4476 PF14771.6 EFC37146.1 - 8.8e-15 54.8 0.1 2.3e-14 53.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) MFS_1 PF07690.16 EFC37147.1 - 3.4e-07 29.5 9.1 1.9e-06 27.0 9.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Cucumo_coat PF00760.18 EFC37148.1 - 0.11 12.1 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Cucumovirus coat protein Actin PF00022.19 EFC37149.1 - 6.7e-39 133.6 0.3 1.5e-19 69.9 0.0 3.1 1 1 2 3 3 3 3 Actin EF-hand_12 PF17901.1 EFC37149.1 - 0.072 13.6 0.0 0.45 11.0 0.0 2.2 3 0 0 3 3 3 0 EF-hand fold domain Vps51 PF08700.11 EFC37150.1 - 1.2 9.2 4.8 2.8 8.1 0.3 3.1 3 1 0 3 3 3 0 Vps51/Vps67 Guanylate_cyc PF00211.20 EFC37151.1 - 2.7e-19 69.5 0.0 9.2e-19 67.8 0.0 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain OpuAC PF04069.12 EFC37151.1 - 7.2e-13 48.7 0.3 1.6e-12 47.6 0.1 1.7 2 0 0 2 2 2 1 Substrate binding domain of ABC-type glycine betaine transport system Histone PF00125.24 EFC37152.1 - 1.4e-48 164.6 3.0 1.5e-48 164.5 3.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 EFC37152.1 - 0.00012 22.4 0.1 0.00018 21.9 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 EFC37152.1 - 0.00018 21.6 0.2 0.00018 21.6 0.2 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 EFC37152.1 - 0.00084 19.9 0.4 0.00096 19.8 0.4 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 EFC37152.1 - 0.0088 16.3 0.7 0.013 15.8 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFC37152.1 - 0.037 14.1 0.4 0.07 13.2 0.2 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Cation_efflux PF01545.21 EFC37153.1 - 4.8e-50 170.1 1.1 7.1e-50 169.5 1.1 1.3 1 0 0 1 1 1 1 Cation efflux family FAM176 PF14851.6 EFC37153.1 - 0.00055 19.6 6.4 0.0095 15.6 0.0 2.4 2 0 0 2 2 2 1 FAM176 family DUF5308 PF17233.2 EFC37153.1 - 0.0029 17.8 0.0 2.7 8.2 0.0 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF5308) PBP1_TM PF14812.6 EFC37153.1 - 0.0031 17.9 9.2 0.043 14.2 1.0 2.4 2 0 0 2 2 2 2 Transmembrane domain of transglycosylase PBP1 at N-terminal Connexin PF00029.19 EFC37153.1 - 0.0032 17.2 3.2 0.045 13.5 0.1 2.6 2 0 0 2 2 2 1 Connexin V_ATPase_I PF01496.19 EFC37153.1 - 0.013 13.5 0.0 0.013 13.5 0.0 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF2370 PF10176.9 EFC37153.1 - 0.015 15.0 0.6 0.27 10.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF4834 PF16118.5 EFC37153.1 - 0.1 13.6 7.2 0.19 12.7 0.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Zip PF02535.22 EFC37153.1 - 0.54 9.4 41.7 0.059 12.6 17.1 2.8 1 1 1 2 2 2 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 EFC37153.1 - 3.8 7.5 5.7 15 5.5 0.4 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TMEM210 PF15195.6 EFC37154.1 - 0.13 12.7 0.2 0.34 11.3 0.2 1.7 1 0 0 1 1 1 0 TMEM210 family Syndecan PF01034.20 EFC37154.1 - 0.89 9.5 3.7 2.5 8.1 3.7 1.7 1 0 0 1 1 1 0 Syndecan domain RGS PF00615.19 EFC37155.1 - 4.6e-09 36.6 0.2 1.2e-08 35.2 0.2 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain TPPII_N PF12583.8 EFC37155.1 - 1.7 9.2 4.4 0.32 11.6 0.8 1.6 2 0 0 2 2 2 0 Tripeptidyl peptidase II N terminal ABC_membrane PF00664.23 EFC37156.1 - 9.1e-43 146.9 18.8 1.3e-42 146.3 18.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC37156.1 - 5.9e-36 124.0 0.0 1.4e-35 122.7 0.0 1.7 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EFC37156.1 - 2.7e-06 27.0 0.2 0.00084 18.8 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 EFC37156.1 - 0.00026 21.1 0.1 0.00086 19.5 0.1 1.9 1 1 0 1 1 1 1 Helicase HerA, central domain AAA_29 PF13555.6 EFC37156.1 - 0.00077 19.2 0.1 0.0025 17.5 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 EFC37156.1 - 0.003 16.9 0.0 0.015 14.6 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 EFC37156.1 - 0.0031 17.8 0.1 0.045 14.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC37156.1 - 0.0068 16.8 1.3 0.38 11.2 0.3 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) G-alpha PF00503.20 EFC37156.1 - 0.014 14.5 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_16 PF13191.6 EFC37156.1 - 0.018 15.5 0.1 0.047 14.1 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFC37156.1 - 0.018 14.9 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 EFC37156.1 - 0.031 14.0 0.1 0.055 13.2 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 EFC37156.1 - 0.049 12.4 0.7 0.072 11.9 0.1 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_5 PF07728.14 EFC37156.1 - 0.079 13.0 0.1 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EFC37156.1 - 0.083 13.1 0.5 0.81 10.0 0.5 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 EFC37156.1 - 0.12 12.1 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain E1-E2_ATPase PF00122.20 EFC37156.1 - 0.47 10.0 9.1 0.36 10.3 0.5 2.7 3 0 0 3 3 3 0 E1-E2 ATPase TcpE PF12648.7 EFC37156.1 - 3.7 8.1 14.3 3.5 8.2 0.1 3.5 3 0 0 3 3 3 0 TcpE family C2 PF00168.30 EFC37157.1 - 1.5e-08 34.8 0.0 2.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 C2 domain Cdc6_C PF09079.11 EFC37158.1 - 0.03 14.3 0.2 0.03 14.3 0.2 1.7 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain Nudix_N_2 PF14803.6 EFC37158.1 - 0.7 9.9 3.6 1.3 9.0 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal AAA_5 PF07728.14 EFC37159.1 - 1.1e-88 294.3 0.0 3e-32 111.5 0.0 3.4 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFC37159.1 - 0.00015 21.9 1.2 0.0042 17.2 0.1 3.4 4 0 0 4 4 4 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFC37159.1 - 0.00027 21.4 0.6 24 5.2 0.0 4.9 4 1 1 5 5 5 0 AAA ATPase domain AAA PF00004.29 EFC37159.1 - 0.0036 17.7 3.6 1.5 9.3 0.0 4.2 4 1 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFC37159.1 - 0.008 15.9 0.1 6.3 6.6 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain Sigma54_activ_2 PF14532.6 EFC37159.1 - 0.033 14.3 0.1 4.8 7.3 0.0 3.0 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EFC37159.1 - 0.049 13.4 0.2 8.2 6.1 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_22 PF13401.6 EFC37159.1 - 0.1 12.9 2.5 58 4.0 0.0 4.6 3 1 1 4 4 4 0 AAA domain DUF2683 PF10884.8 EFC37159.1 - 0.38 11.1 2.7 0.79 10.0 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2683) FliJ PF02050.16 EFC37160.1 - 0.064 13.5 4.3 0.13 12.5 4.3 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein VWA_2 PF13519.6 EFC37160.1 - 0.11 13.2 0.0 0.5 11.0 0.0 2.3 1 0 0 1 1 1 0 von Willebrand factor type A domain Glu_synthase PF01645.17 EFC37161.1 - 0.029 13.5 0.3 0.05 12.7 0.3 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase Wzy_C_2 PF11846.8 EFC37161.1 - 0.19 11.6 0.2 0.26 11.2 0.2 1.2 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal Abhydrolase_1 PF00561.20 EFC37162.1 - 1.7e-12 47.5 0.0 3.2e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ank_5 PF13857.6 EFC37162.1 - 5.3e-08 33.0 0.1 1.2e-07 31.9 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC37162.1 - 1e-07 32.4 0.0 2.2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Hydrolase_4 PF12146.8 EFC37162.1 - 1.7e-07 30.8 0.0 2.8e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC37162.1 - 3.2e-06 27.9 0.0 4.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank PF00023.30 EFC37162.1 - 4.3e-05 23.8 0.1 0.00015 22.0 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EFC37162.1 - 0.00024 21.6 0.1 0.0034 17.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC37162.1 - 0.0064 16.9 0.1 0.035 14.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Glyco_transf_9 PF01075.17 EFC37162.1 - 0.12 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 9 (heptosyltransferase) DOMON PF03351.17 EFC37163.1 - 9.6e-21 74.3 2.6 3.5e-09 36.9 0.1 3.1 3 0 0 3 3 3 2 DOMON domain Ferric_reduct PF01794.19 EFC37163.1 - 4.9e-17 62.2 16.1 1.3e-16 60.8 16.1 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFC37163.1 - 4.6e-13 49.6 0.3 8.4e-10 39.0 0.3 2.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC37163.1 - 6.6e-07 29.4 0.1 1.5e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFC37163.1 - 4.5e-06 27.3 0.0 9.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PrkA PF06798.12 EFC37163.1 - 0.2 11.3 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain Lactamase_B_2 PF12706.7 EFC37164.1 - 1.9e-17 63.4 0.0 2.5e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC37164.1 - 2.6e-11 43.7 0.1 3.7e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFC37164.1 - 0.019 15.0 0.1 0.048 13.6 0.1 1.7 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Pkinase PF00069.25 EFC37165.1 - 3.3e-41 141.4 1.0 3.3e-41 141.4 1.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37165.1 - 4.6e-31 108.0 0.3 8.3e-31 107.2 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC37165.1 - 1.2e-20 73.8 0.6 3e-10 40.6 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC37165.1 - 3.2e-15 56.3 1.0 1.5e-06 28.6 0.0 3.5 3 0 0 3 3 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC37165.1 - 1.1e-14 53.1 0.7 0.0082 16.6 0.0 5.2 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 EFC37165.1 - 1.2e-09 38.1 2.4 0.19 12.3 0.0 5.1 4 1 1 5 5 4 3 Ankyrin repeat Ank_5 PF13857.6 EFC37165.1 - 1.9e-09 37.6 0.9 0.074 13.4 0.1 4.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) HECT PF00632.25 EFC37165.1 - 6.1e-08 32.5 11.0 6.1e-08 32.5 11.0 2.4 2 1 0 2 2 2 1 HECT-domain (ubiquitin-transferase) APH PF01636.23 EFC37165.1 - 0.0013 18.7 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC37165.1 - 0.011 14.6 0.0 0.021 13.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EFC37165.1 - 0.04 13.3 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NifW PF03206.14 EFC37165.1 - 0.08 13.5 0.5 2.5 8.7 0.0 2.8 2 0 0 2 2 2 0 Nitrogen fixation protein NifW Uds1 PF15456.6 EFC37165.1 - 0.21 11.8 3.6 0.29 11.3 1.6 2.3 2 0 0 2 2 2 0 Up-regulated During Septation CENP-F_leu_zip PF10473.9 EFC37165.1 - 0.25 11.4 10.2 0.81 9.7 10.2 1.8 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EFC37165.1 - 0.39 11.2 7.2 1.3 9.6 7.2 1.9 1 0 0 1 1 1 0 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 EFC37165.1 - 0.46 10.7 6.1 1.2 9.4 6.1 1.6 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Mod_r PF07200.13 EFC37165.1 - 9.5 6.3 11.9 0.49 10.5 3.2 3.1 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein KRTAP PF11759.8 EFC37166.1 - 0.00089 19.8 62.9 1.8e+04 -22.7 62.9 3.3 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 EFC37166.1 - 0.022 14.9 58.8 1.8e+04 -21.3 58.8 3.5 1 1 0 1 1 1 0 Keratin type II head RcpB PF16971.5 EFC37167.1 - 0.06 13.2 4.0 0.08 12.8 3.2 1.7 1 1 0 1 1 1 0 Rough colony protein B, tight adherence - tad - subunit HD PF01966.22 EFC37169.1 - 2.6e-10 40.6 1.6 6.4e-10 39.3 0.6 2.3 2 1 0 2 2 2 1 HD domain PDEase_I PF00233.19 EFC37169.1 - 0.023 14.4 3.4 0.24 11.1 0.5 3.0 3 0 0 3 3 3 0 3'5'-cyclic nucleotide phosphodiesterase zf_UBZ PF18439.1 EFC37170.1 - 0.054 13.1 1.7 7.5 6.3 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF3677 PF12432.8 EFC37171.1 - 1.1e-05 25.7 0.7 0.00019 21.7 0.0 3.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3677) Cullin_Nedd8 PF10557.9 EFC37171.1 - 0.033 14.2 0.5 0.49 10.5 0.1 3.0 2 0 0 2 2 2 0 Cullin protein neddylation domain Pox_EPC_I2-L1 PF12575.8 EFC37171.1 - 0.079 13.2 0.4 2.2 8.6 0.1 3.2 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Dcc1 PF09724.9 EFC37172.1 - 3.3e-42 145.0 4.6 8.6e-42 143.6 4.6 1.6 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Myosin_head PF00063.21 EFC37173.1 - 2.6e-260 865.4 6.2 3.3e-260 865.0 6.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFC37173.1 - 4.8e-34 117.7 2.4 8.9e-34 116.8 1.5 1.9 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.6 EFC37173.1 - 2.4e-16 59.3 0.1 7.4e-16 57.7 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFC37173.1 - 8.6e-16 57.3 0.1 2.1e-15 56.0 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFC37173.1 - 2.9e-13 49.3 0.0 6.2e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain AAA_10 PF12846.7 EFC37173.1 - 0.024 13.6 0.1 0.076 11.9 0.1 1.8 1 0 0 1 1 1 0 AAA-like domain AAA_16 PF13191.6 EFC37173.1 - 0.025 15.0 0.1 0.081 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Hpr_kinase_C PF07475.12 EFC37173.1 - 0.063 12.8 0.5 0.71 9.4 0.1 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain IQ PF00612.27 EFC37173.1 - 0.077 12.8 0.2 0.22 11.4 0.2 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif Zeta_toxin PF06414.12 EFC37173.1 - 0.15 11.4 0.1 0.33 10.2 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin C2 PF00168.30 EFC37175.1 - 1.9e-15 57.0 0.1 3.7e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 C2 domain FPRL1_inhibitor PF16104.5 EFC37175.1 - 0.0091 16.1 0.8 2.8 8.1 0.1 2.4 2 0 0 2 2 2 2 Formyl peptide receptor-like 1 inhibitory protein TORC_N PF12884.7 EFC37175.1 - 1.4 9.8 4.8 9.4 7.1 0.1 2.8 3 0 0 3 3 3 0 Transducer of regulated CREB activity, N terminus CRT-like PF08627.10 EFC37177.1 - 2.1e-53 181.4 32.7 2.9e-53 181.0 32.7 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 EFC37177.1 - 2.8e-07 30.3 17.2 2.8e-07 30.3 17.2 2.5 1 1 1 2 2 2 2 Solute carrier family 35 EamA PF00892.20 EFC37177.1 - 0.00012 22.3 42.2 0.00052 20.2 16.7 3.2 3 0 0 3 3 3 2 EamA-like transporter family UCH PF00443.29 EFC37178.1 - 9.2e-30 104.0 1.4 9.2e-30 104.0 1.4 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 EFC37178.1 - 5.2e-11 42.7 0.3 9.9e-11 41.8 0.3 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Pkinase PF00069.25 EFC37179.1 - 6.4e-52 176.5 1.3 9.1e-52 176.0 0.4 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37179.1 - 7.1e-52 176.2 0.1 4.3e-51 173.7 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC37179.1 - 0.02 13.7 0.0 0.044 12.6 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase Chlam_PMP PF02415.17 EFC37179.1 - 0.098 13.2 16.7 0.5 11.0 0.6 4.6 4 0 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat HEPN_Swt1 PF18731.1 EFC37180.1 - 3.1e-18 66.2 1.8 3.1e-18 66.2 1.8 2.7 2 2 0 2 2 2 1 Swt1-like HEPN HEPN_RiboL-PSP PF18735.1 EFC37180.1 - 0.0057 16.6 0.2 0.0057 16.6 0.2 1.9 1 1 1 2 2 2 1 RiboL-PSP-HEPN CTD_bind PF04818.13 EFC37180.1 - 0.012 16.5 0.1 0.048 14.5 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase II-binding domain. MAS20 PF02064.15 EFC37180.1 - 0.22 11.6 2.4 0.44 10.6 2.4 1.5 1 0 0 1 1 1 0 MAS20 protein import receptor Presenilin PF01080.17 EFC37180.1 - 1.9 7.2 4.3 2.2 6.9 4.3 1.1 1 0 0 1 1 1 0 Presenilin DUF4116 PF13475.6 EFC37181.1 - 2e-73 241.9 18.1 8.3e-13 47.8 0.2 9.8 4 2 5 10 10 10 10 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC37181.1 - 1.4e-17 64.0 0.6 7.6e-17 61.5 0.6 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37181.1 - 8.9e-11 41.5 0.1 0.00037 19.9 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase PMEI PF04043.15 EFC37181.1 - 0.01 16.2 0.1 0.019 15.3 0.1 1.4 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Mei5_like PF17021.5 EFC37181.1 - 2.9 8.0 14.8 2.7 8.1 0.9 4.3 4 1 0 4 4 4 0 Putative double-strand recombination repair-like SirA PF10747.9 EFC37182.1 - 0.0099 16.2 0.7 0.024 14.9 0.7 1.8 1 0 0 1 1 1 1 Sporulation inhibitor of replication protein SirA Adeno_E3_CR2 PF02439.15 EFC37182.1 - 3.3 7.5 9.1 7.7 6.4 9.1 1.6 1 1 0 1 1 1 0 Adenovirus E3 region protein CR2 Cas_APE2256 PF09651.10 EFC37184.1 - 0.092 12.6 0.4 0.24 11.3 0.4 1.7 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) ABC2_membrane_3 PF12698.7 EFC37185.1 - 0.071 12.2 0.1 0.072 12.2 0.1 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Internalin_N PF12354.8 EFC37185.1 - 0.16 12.1 0.4 0.27 11.3 0.4 1.3 1 0 0 1 1 1 0 Bacterial adhesion/invasion protein N terminal CbtA PF09490.10 EFC37186.1 - 0.01 15.6 1.8 0.016 15.0 1.8 1.4 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) DUF4064 PF13273.6 EFC37186.1 - 2.3 8.5 16.1 7.5 6.9 14.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF5134 PF17197.4 EFC37186.1 - 3 7.7 6.4 8.1 6.3 6.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5134) Phage_holin_3_6 PF07332.11 EFC37186.1 - 3.7 7.6 9.8 5.9 7.0 9.8 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III LRR_4 PF12799.7 EFC37187.1 - 1.4e-06 28.5 43.4 8.2e-05 22.9 3.4 8.3 4 3 4 8 8 8 3 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC37187.1 - 9.7e-06 25.3 0.2 2.6e-05 23.9 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC37187.1 - 0.0036 17.1 0.1 0.0088 15.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EFC37187.1 - 0.23 11.6 13.1 17 5.8 0.3 6.4 6 0 0 6 6 6 0 Leucine Rich repeat LRR_8 PF13855.6 EFC37187.1 - 2.7 7.8 22.8 0.89 9.4 0.5 5.9 5 1 1 6 6 6 0 Leucine rich repeat SPRY PF00622.28 EFC37188.1 - 0.005 16.9 0.3 0.008 16.3 0.3 1.4 1 0 0 1 1 1 1 SPRY domain DUF2678 PF10856.8 EFC37189.1 - 8.7e-06 25.7 4.2 8.9e-06 25.6 2.8 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2678) AA_permease_2 PF13520.6 EFC37189.1 - 0.018 13.9 8.0 0.022 13.6 8.0 1.0 1 0 0 1 1 1 0 Amino acid permease UPF0697 PF15117.6 EFC37189.1 - 0.28 11.3 0.8 0.43 10.7 0.2 1.6 1 1 1 2 2 2 0 Uncharacterised protein family UPF0697 TssN PF17555.2 EFC37189.1 - 0.43 9.9 6.2 0.53 9.6 6.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN tRNA_synthFbeta PF17759.1 EFC37190.1 - 2.8e-45 154.4 0.0 4.2e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 EFC37190.1 - 4.4e-26 91.6 0.1 7.5e-26 90.9 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain PhetRS_B1 PF18262.1 EFC37190.1 - 2.3e-24 85.4 0.8 8.8e-24 83.5 0.2 2.3 2 1 1 3 3 3 1 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 EFC37190.1 - 2.1e-20 72.8 0.0 3.4e-17 62.5 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain M_domain PF12938.7 EFC37191.1 - 0.96 9.2 5.6 1.9 8.2 5.6 1.4 1 0 0 1 1 1 0 M domain of GW182 ADH_N PF08240.12 EFC37192.1 - 5.3e-19 68.1 1.0 8.6e-19 67.4 1.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC37192.1 - 6.2e-18 65.0 0.0 1.3e-17 64.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC37192.1 - 1e-06 29.8 0.0 1.8e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFC37192.1 - 0.00027 20.3 0.0 0.00047 19.5 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EFC37192.1 - 0.0008 18.8 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Latexin PF06907.12 EFC37192.1 - 0.015 14.8 0.2 0.69 9.4 0.0 2.1 1 1 1 2 2 2 0 Latexin NAD_binding_2 PF03446.15 EFC37192.1 - 0.15 12.2 0.1 0.56 10.4 0.0 2.0 1 1 1 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 EFC37193.1 - 3.1e-17 62.9 0.1 5.2e-17 62.2 0.1 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFC37193.1 - 1.7e-08 34.8 0.2 1.1e-07 32.1 0.0 2.2 3 0 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFC37193.1 - 4.4e-07 29.4 0.0 7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Rossmann-like PF10727.9 EFC37193.1 - 1.7e-06 27.9 0.1 2.8e-06 27.2 0.1 1.3 1 0 0 1 1 1 1 Rossmann-like domain IlvN PF07991.12 EFC37193.1 - 7e-05 22.4 0.0 0.00011 21.9 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_Gly3P_dh_N PF01210.23 EFC37193.1 - 0.00099 19.1 0.6 0.066 13.2 0.6 2.3 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 EFC37193.1 - 0.007 16.3 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EFC37193.1 - 0.015 14.9 0.5 0.12 12.1 0.5 2.2 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 EFC37193.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EFC37193.1 - 0.05 14.2 0.1 0.12 13.0 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GFO_IDH_MocA PF01408.22 EFC37193.1 - 0.051 14.4 0.0 0.093 13.6 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Shikimate_DH PF01488.20 EFC37193.1 - 0.093 12.8 0.2 0.42 10.7 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 EFC37193.1 - 0.15 11.6 0.5 0.56 9.8 0.1 1.9 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Actin PF00022.19 EFC37194.1 - 1.1e-54 185.7 0.0 5.6e-30 104.3 0.0 2.1 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFC37194.1 - 0.0023 16.8 0.1 0.034 13.0 0.0 2.3 2 1 0 2 2 2 1 MreB/Mbl protein PilM_2 PF11104.8 EFC37194.1 - 0.12 11.3 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; Far-17a_AIG1 PF04750.14 EFC37195.1 - 8.1e-06 25.3 13.5 6.5e-05 22.3 8.2 2.5 1 1 1 2 2 2 2 FAR-17a/AIG1-like protein Shisa PF13908.6 EFC37195.1 - 0.018 15.3 0.0 0.2 11.8 0.0 2.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Ly49 PF08391.10 EFC37195.1 - 0.16 12.3 0.2 2.2 8.6 0.0 2.4 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF4446 PF14584.6 EFC37195.1 - 0.2 11.6 0.4 0.61 10.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) TMEM156 PF15106.6 EFC37195.1 - 0.7 9.3 3.5 1.3 8.4 3.5 1.5 1 0 0 1 1 1 0 TMEM156 protein family HemY_N PF07219.13 EFC37195.1 - 1.9 8.7 7.1 0.84 9.9 2.2 2.8 3 0 0 3 3 3 0 HemY protein N-terminus EST1 PF10374.9 EFC37196.1 - 0.026 15.2 0.2 0.11 13.1 0.1 2.0 2 0 0 2 2 2 0 Telomerase activating protein Est1 Draxin PF15550.6 EFC37196.1 - 0.037 13.9 0.8 0.063 13.2 0.8 1.3 1 0 0 1 1 1 0 Draxin Pox_A21 PF05323.12 EFC37196.1 - 0.1 13.1 1.1 1.3 9.7 0.3 2.7 2 0 0 2 2 2 0 Poxvirus A21 Protein DUF4116 PF13475.6 EFC37198.1 - 2.3e-53 177.7 26.5 4.6e-11 42.3 0.0 11.7 6 3 4 10 10 10 9 Domain of unknown function (DUF4116) DUF2247 PF10004.9 EFC37198.1 - 0.82 9.4 6.1 1.2 9.0 0.1 3.6 3 2 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2247) MFS_1 PF07690.16 EFC37199.1 - 4.7e-21 75.1 17.3 4.7e-21 75.1 17.3 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily UPF0182 PF03699.13 EFC37199.1 - 5.6 5.0 10.4 0.53 8.3 1.9 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) START PF01852.19 EFC37200.1 - 0.00041 19.8 0.0 0.0012 18.3 0.0 1.7 1 1 0 1 1 1 1 START domain RGS PF00615.19 EFC37200.1 - 0.047 14.0 0.3 0.047 14.0 0.3 3.1 3 0 0 3 3 3 0 Regulator of G protein signaling domain ZZ PF00569.17 EFC37201.1 - 5.7e-14 51.6 21.1 3.7e-08 33.0 7.0 3.5 3 0 0 3 3 3 2 Zinc finger, ZZ type C1_2 PF03107.16 EFC37201.1 - 2e-05 24.8 25.0 0.014 15.7 8.4 3.6 3 0 0 3 3 3 2 C1 domain F-box-like PF12937.7 EFC37201.1 - 0.00079 19.3 0.1 0.0016 18.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like Sgf11 PF08209.11 EFC37201.1 - 0.85 9.2 6.0 13 5.4 0.2 3.3 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) Ferric_reduct PF01794.19 EFC37202.1 - 5e-17 62.2 16.4 1.3e-16 60.8 16.4 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component DOMON PF03351.17 EFC37202.1 - 4.9e-15 55.8 1.1 1e-10 41.9 0.1 3.1 3 0 0 3 3 3 2 DOMON domain NAD_binding_6 PF08030.12 EFC37202.1 - 5.3e-13 49.4 0.4 2.5e-07 31.0 0.1 2.7 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC37202.1 - 1.2e-06 28.6 0.1 2.5e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFC37202.1 - 4.9e-06 27.2 0.0 1e-05 26.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PrkA PF06798.12 EFC37202.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain RCC1 PF00415.18 EFC37204.1 - 1.6e-06 28.6 0.0 0.0022 18.6 0.0 2.7 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Adeno_GP19K PF04881.13 EFC37204.1 - 0.057 13.4 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Adenovirus GP19K RCC1_2 PF13540.6 EFC37204.1 - 0.62 9.9 2.8 1.4 8.8 0.0 2.9 4 0 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37205.1 - 4.1e-07 29.6 0.0 0.075 12.9 0.0 3.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37205.1 - 2.3e-05 24.9 0.2 0.00013 22.5 0.1 2.4 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Lactamase_B_4 PF13691.6 EFC37205.1 - 0.029 14.0 0.0 0.091 12.4 0.0 1.8 1 0 0 1 1 1 0 tRNase Z endonuclease Pkinase PF00069.25 EFC37206.1 - 5.8e-21 75.0 4.6 1.5e-20 73.7 2.3 2.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37206.1 - 2.7e-15 56.4 0.4 5.1e-15 55.4 0.4 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HECT PF00632.25 EFC37206.1 - 6.2e-09 35.8 11.0 6.2e-09 35.8 11.0 2.8 2 2 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Kdo PF06293.14 EFC37206.1 - 0.027 13.8 0.0 0.067 12.5 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tho1_MOS11_C PF18592.1 EFC37206.1 - 0.045 13.6 3.7 1.3 8.9 0.3 2.7 2 0 0 2 2 2 0 Tho1/MOS11 C-terminal domain NPV_P10 PF05531.12 EFC37206.1 - 0.063 13.7 8.6 0.044 14.3 2.5 3.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APH PF01636.23 EFC37206.1 - 0.071 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FlaC_arch PF05377.11 EFC37206.1 - 0.54 10.7 20.3 1.5 9.3 2.9 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 EFC37206.1 - 0.8 9.0 11.6 0.098 11.9 4.9 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) Caldesmon PF02029.15 EFC37206.1 - 2 7.1 14.0 3.5 6.3 14.0 1.2 1 0 0 1 1 1 0 Caldesmon Jnk-SapK_ap_N PF09744.9 EFC37206.1 - 2.2 8.5 21.1 3.9 7.7 5.9 2.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 SlyX PF04102.12 EFC37206.1 - 2.2 8.9 10.7 2.4 8.8 1.2 4.2 4 0 0 4 4 4 0 SlyX DUF4407 PF14362.6 EFC37206.1 - 2.3 7.5 5.3 3.9 6.8 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 EFC37206.1 - 2.6 8.3 24.2 0.038 14.2 8.8 3.6 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 EFC37206.1 - 3.3 7.8 14.0 3.1 7.8 7.3 3.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3275 PF11679.8 EFC37207.1 - 0.11 12.5 1.7 0.16 12.0 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) Baculo_19 PF04798.12 EFC37208.1 - 0.067 12.9 0.8 0.098 12.4 0.2 1.5 2 0 0 2 2 2 0 Baculovirus 19 kDa protein conserved region Abhydrolase_2 PF02230.16 EFC37209.1 - 1e-44 152.9 0.0 1.4e-44 152.5 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFC37209.1 - 1.1e-08 34.6 0.0 0.0047 16.2 0.0 3.2 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC37209.1 - 6.4e-05 23.7 0.0 0.00032 21.4 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EFC37209.1 - 0.00015 21.7 0.0 0.0011 18.9 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC37209.1 - 0.00021 20.8 0.6 0.2 11.1 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase family FSH1 PF03959.13 EFC37209.1 - 0.00051 19.8 0.0 0.0037 17.0 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Asp2 PF16929.5 EFC37209.1 - 0.00084 18.4 0.6 0.0013 17.8 0.0 1.5 2 0 0 2 2 2 1 Accessory Sec system GspB-transporter DLH PF01738.18 EFC37209.1 - 0.0012 18.5 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Esterase_phd PF10503.9 EFC37209.1 - 0.0054 16.2 0.0 0.086 12.3 0.0 2.1 2 0 0 2 2 2 1 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 EFC37209.1 - 0.0069 16.1 0.7 0.47 10.0 0.4 2.7 1 1 1 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 EFC37209.1 - 0.052 12.2 0.0 0.095 11.3 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF2974 PF11187.8 EFC37209.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PhoPQ_related PF10142.9 EFC37210.1 - 4.4e-97 325.0 0.3 5.5e-97 324.7 0.3 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein EamA PF00892.20 EFC37211.1 - 4.7e-06 26.8 40.8 2.2e-05 24.7 19.8 4.3 3 1 1 4 4 4 3 EamA-like transporter family Connexin PF00029.19 EFC37211.1 - 0.0095 15.7 6.0 0.62 9.8 0.2 3.2 3 0 0 3 3 3 2 Connexin DUF1077 PF06417.12 EFC37211.1 - 0.6 10.1 6.2 3.8 7.5 4.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1077) SRA PF18491.1 EFC37211.1 - 1.2 9.3 4.9 3.5 7.7 0.3 2.8 3 0 0 3 3 3 0 SET and RING associated domain Cofilin_ADF PF00241.20 EFC37212.1 - 2.1e-23 82.4 0.7 2.4e-23 82.2 0.7 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SelP_C PF04593.14 EFC37212.1 - 0.0092 16.0 0.6 0.012 15.6 0.6 1.2 1 0 0 1 1 1 1 Selenoprotein P, C terminal region RhoGEF PF00621.20 EFC37213.1 - 6.7e-16 59.0 10.5 6.7e-16 59.0 10.5 2.6 1 1 1 2 2 2 1 RhoGEF domain PH PF00169.29 EFC37213.1 - 0.031 14.8 0.3 0.031 14.8 0.3 3.3 2 1 0 3 3 3 0 PH domain Histone PF00125.24 EFC37214.1 - 4e-19 69.3 4.3 4e-19 69.3 4.3 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFC37214.1 - 9.1e-07 29.1 0.1 2.9e-06 27.5 0.1 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GMP_synt_C PF00958.22 EFC37214.1 - 0.0034 17.4 0.1 0.0054 16.8 0.1 1.3 1 0 0 1 1 1 1 GMP synthase C terminal domain DUF3915 PF13054.6 EFC37214.1 - 2 8.4 5.6 0.42 10.6 0.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3915) FAM176 PF14851.6 EFC37214.1 - 9 6.0 10.0 0.47 10.1 1.7 2.2 2 0 0 2 2 2 0 FAM176 family DAP3 PF10236.9 EFC37215.1 - 2.5e-34 118.9 0.0 1.2e-32 113.4 0.0 2.6 1 1 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Ank_2 PF12796.7 EFC37216.1 - 8.2e-11 42.3 0.0 2e-07 31.5 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC37216.1 - 9.1e-08 31.8 0.0 2.3e-05 24.4 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFC37216.1 - 6.6e-07 29.5 0.0 6.8e-05 23.1 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFC37216.1 - 9.9e-07 29.2 0.0 0.0022 18.5 0.0 2.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC37216.1 - 0.00031 21.0 0.0 0.046 14.0 0.0 2.5 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Rif1_N PF12231.8 EFC37216.1 - 0.15 11.0 0.0 0.22 10.5 0.0 1.3 1 1 0 1 1 1 0 Rap1-interacting factor 1 N terminal NHL PF01436.21 EFC37217.1 - 1.2e-14 53.5 0.1 0.4 10.8 0.0 9.0 10 0 0 10 10 10 4 NHL repeat SGL PF08450.12 EFC37217.1 - 2.6e-06 27.2 1.3 0.082 12.5 0.1 5.8 3 2 2 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC37217.1 - 0.00034 20.7 0.2 3.2 7.6 0.0 3.4 2 1 1 3 3 3 2 Esterase-like activity of phytase CD34_antigen PF06365.12 EFC37217.1 - 0.17 11.5 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family PX PF00787.24 EFC37219.1 - 1.2e-07 31.7 1.2 2.6e-07 30.6 1.2 1.6 1 0 0 1 1 1 1 PX domain F-box PF00646.33 EFC37219.1 - 0.021 14.7 0.9 0.072 13.0 0.1 2.2 2 0 0 2 2 2 0 F-box domain SPT2 PF08243.11 EFC37219.1 - 0.11 13.1 2.5 0.28 11.7 2.5 1.7 1 0 0 1 1 1 0 SPT2 chromatin protein G-alpha PF00503.20 EFC37220.1 - 1.5e-109 366.4 10.2 1.8e-109 366.1 10.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC37220.1 - 4.2e-12 45.9 1.7 1.2e-08 34.6 0.5 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC37220.1 - 2.4e-05 23.8 1.6 0.0077 15.6 1.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC37220.1 - 0.0019 18.4 0.9 2 8.6 0.0 3.0 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC37220.1 - 0.006 16.2 1.0 0.049 13.2 0.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC37220.1 - 0.021 14.9 0.1 5.4 7.1 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC37220.1 - 0.12 12.1 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Abhydrolase_3 PF07859.13 EFC37221.1 - 4.5e-19 69.1 0.0 6e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC37221.1 - 8.1e-11 41.4 0.0 3.5e-10 39.3 0.0 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 EFC37221.1 - 4e-06 26.0 0.0 0.025 13.5 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family DUF900 PF05990.12 EFC37221.1 - 0.15 11.6 0.0 2.8 7.4 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Ank_2 PF12796.7 EFC37222.1 - 7.9e-09 36.0 0.2 0.0021 18.6 0.0 4.7 2 2 3 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC37222.1 - 0.00036 21.0 0.7 0.6 10.8 0.4 4.1 4 1 2 6 6 6 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC37222.1 - 0.00073 19.8 0.6 0.2 12.3 0.3 4.5 6 0 0 6 6 6 1 Ankyrin repeat Ank_5 PF13857.6 EFC37222.1 - 0.00085 19.6 0.3 0.38 11.1 0.1 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) RCC1_2 PF13540.6 EFC37223.1 - 2e-07 30.6 0.0 8.2e-06 25.5 0.0 2.7 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37223.1 - 0.0017 19.0 0.1 4 8.1 0.0 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat PLN_propep PF16485.5 EFC37223.1 - 0.012 15.3 0.2 0.091 12.5 0.0 2.2 2 0 0 2 2 2 0 Protealysin propeptide dCache_1 PF02743.18 EFC37223.1 - 0.11 12.3 4.9 0.26 11.0 1.6 2.6 2 0 0 2 2 2 0 Cache domain DUF4476 PF14771.6 EFC37224.1 - 2.9e-16 59.5 0.4 4.5e-16 58.9 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4476) Swm2 PF17083.5 EFC37225.1 - 0.012 15.6 1.4 0.15 12.0 0.1 2.8 2 1 1 3 3 3 0 Nucleolar protein Swm2 Zn_clus PF00172.18 EFC37226.1 - 5.4e-08 32.8 10.9 1.4e-07 31.5 10.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TERB2 PF15101.6 EFC37226.1 - 0.11 12.6 4.4 0.091 12.8 0.6 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 SPG4 PF17325.2 EFC37226.1 - 0.31 12.1 7.1 0.12 13.5 0.9 2.4 2 0 0 2 2 2 0 Stationary phase protein 4 DUF382 PF04037.13 EFC37226.1 - 0.49 10.5 3.3 15 5.8 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF382) DUF2072 PF09845.9 EFC37226.1 - 0.82 9.9 11.5 0.052 13.8 5.9 1.9 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF1178 PF06676.11 EFC37226.1 - 2.9 8.3 7.6 0.49 10.8 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) CD225 PF04505.12 EFC37227.1 - 0.15 12.2 0.4 0.61 10.3 0.0 2.0 2 0 0 2 2 2 0 Interferon-induced transmembrane protein DUF4316 PF14195.6 EFC37227.1 - 0.83 9.5 3.7 0.42 10.4 1.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4316) EGF_2 PF07974.13 EFC37228.1 - 1.2e-34 118.3 241.9 6.9e-05 23.1 7.8 15.9 15 1 1 16 16 16 12 EGF-like domain NHL PF01436.21 EFC37228.1 - 4.1e-26 89.6 3.2 0.0014 18.6 0.0 10.8 10 0 0 10 10 10 7 NHL repeat YafQ_toxin PF15738.5 EFC37229.1 - 2.1 8.7 4.4 1 9.7 0.9 2.3 2 0 0 2 2 2 0 Bacterial toxin of type II toxin-antitoxin system, YafQ Ank_2 PF12796.7 EFC37230.1 - 6.2e-06 26.7 1.4 0.25 12.0 0.1 4.7 4 1 1 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC37230.1 - 1e-05 25.5 4.9 2.3 9.0 0.3 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFC37230.1 - 0.0067 16.7 3.3 2.6 8.5 0.1 4.2 4 1 0 4 4 4 2 Ankyrin repeats (many copies) ABC_tran PF00005.27 EFC37231.1 - 4.4e-28 98.5 0.0 1e-27 97.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFC37231.1 - 0.0039 17.0 2.9 0.57 9.9 0.0 2.6 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SieB PF14163.6 EFC37231.1 - 0.0089 15.5 0.9 0.0089 15.5 0.9 3.8 4 0 0 4 4 4 1 Super-infection exclusion protein B SMC_N PF02463.19 EFC37231.1 - 0.01 15.3 0.0 0.043 13.2 0.0 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF4162 PF13732.6 EFC37231.1 - 0.015 16.0 0.2 0.015 16.0 0.2 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4162) AAA_23 PF13476.6 EFC37231.1 - 8.6 6.8 9.1 0.58 10.6 2.2 2.4 2 1 0 2 2 2 0 AAA domain F-box-like PF12937.7 EFC37232.1 - 0.067 13.1 1.2 0.24 11.3 1.2 1.9 1 1 0 1 1 1 0 F-box-like Pkinase PF00069.25 EFC37233.1 - 4.9e-07 29.4 0.1 1.4e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC37233.1 - 0.0002 20.3 0.0 0.00028 19.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 EFC37233.1 - 0.025 13.8 0.0 0.046 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein tyrosine kinase Thrombin_light PF09396.10 EFC37233.1 - 0.053 13.3 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Thrombin light chain APH PF01636.23 EFC37233.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC37233.1 - 0.13 11.8 8.4 0.088 12.4 5.1 2.5 2 1 0 2 2 2 0 Choline/ethanolamine kinase NAPRTase_N PF17767.1 EFC37234.1 - 0.12 12.8 0.1 1.8 8.9 0.1 2.2 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain RNase_H PF00075.24 EFC37235.1 - 0.002 18.3 0.1 0.0056 16.9 0.1 1.8 1 1 0 1 1 1 1 RNase H RecQ_Zn_bind PF16124.5 EFC37235.1 - 4.4 8.1 11.7 60 4.5 11.7 2.4 1 1 0 1 1 1 0 RecQ zinc-binding Aldo_ket_red PF00248.21 EFC37236.1 - 9.7e-75 251.5 0.0 1.2e-74 251.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_L2 PF00181.23 EFC37236.1 - 0.095 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain ETF PF01012.21 EFC37237.1 - 3e-34 118.5 0.0 4.1e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Toxin_10 PF05431.11 EFC37239.1 - 0.11 11.9 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Insecticidal Crystal Toxin, P42 MHC_II_beta PF00969.19 EFC37240.1 - 0.15 12.2 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Class II histocompatibility antigen, beta domain GSCFA PF08885.11 EFC37241.1 - 0.093 12.4 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 GSCFA family WTF PF03303.13 EFC37241.1 - 2.9 7.5 9.3 0.11 12.2 2.5 1.8 1 1 1 2 2 2 0 WTF protein DUF4116 PF13475.6 EFC37243.1 - 4.6e-06 26.2 26.9 3.4e-05 23.5 2.4 5.1 4 2 2 6 6 6 2 Domain of unknown function (DUF4116) F-box PF00646.33 EFC37243.1 - 0.0014 18.4 1.0 0.0046 16.8 0.4 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC37243.1 - 0.037 13.9 0.1 0.1 12.5 0.1 1.8 1 0 0 1 1 1 0 F-box-like TrmE_N PF10396.9 EFC37243.1 - 0.062 13.6 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 GTP-binding protein TrmE N-terminus Mistic PF11458.8 EFC37243.1 - 1.3 9.1 7.5 0.29 11.1 2.7 2.5 2 0 0 2 2 2 0 Membrane-integrating protein Mistic LPD11 PF18824.1 EFC37243.1 - 1.4 9.1 6.1 0.31 11.2 0.1 3.0 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 Sod_Fe_C PF02777.18 EFC37244.1 - 1.4e-37 127.9 0.9 3.5e-37 126.7 0.3 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFC37244.1 - 5.1e-25 87.8 2.1 9.4e-25 86.9 2.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF5617 PF18493.1 EFC37244.1 - 0.068 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) Gp_dh_C PF02800.20 EFC37245.1 - 1.6e-67 226.0 0.1 2.7e-67 225.3 0.1 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 EFC37245.1 - 1.8e-41 140.6 1.1 1.2e-40 137.9 0.2 2.3 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 EFC37245.1 - 0.011 15.9 0.0 0.037 14.1 0.0 2.0 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NMO PF03060.15 EFC37246.1 - 7.4e-72 242.5 0.0 8.2e-72 242.4 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFC37246.1 - 1.3e-12 47.4 0.2 3.5e-05 23.0 0.0 2.1 1 1 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain DUF561 PF04481.12 EFC37246.1 - 4.8e-08 32.5 1.8 6.5e-08 32.0 0.5 1.8 2 1 1 3 3 3 1 Protein of unknown function (DUF561) DHO_dh PF01180.21 EFC37246.1 - 2.2e-05 23.8 0.1 3e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EFC37246.1 - 9.5e-05 22.0 0.2 0.00032 20.2 0.2 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein FMN_dh PF01070.18 EFC37246.1 - 0.00025 20.2 1.1 0.00042 19.5 0.2 1.7 2 0 0 2 2 2 1 FMN-dependent dehydrogenase ThiG PF05690.14 EFC37246.1 - 0.00035 20.0 0.1 0.00058 19.2 0.1 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG NanE PF04131.14 EFC37246.1 - 0.00053 19.2 0.1 0.001 18.3 0.1 1.4 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.17 EFC37246.1 - 0.0063 15.9 0.8 0.02 14.2 0.8 1.8 1 1 0 1 1 1 1 Thiamine monophosphate synthase PEP_hydrolase PF09370.10 EFC37246.1 - 0.0078 15.5 0.2 1.4 8.1 0.2 2.1 2 0 0 2 2 2 2 Phosphoenolpyruvate hydrolase-like G3P_antiterm PF04309.12 EFC37246.1 - 0.015 14.7 0.1 0.029 13.8 0.1 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator IF2_N PF04760.15 EFC37246.1 - 0.031 14.1 0.3 1.9 8.4 0.0 3.3 4 0 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region Dus PF01207.17 EFC37246.1 - 0.12 11.4 0.1 0.48 9.5 0.0 1.9 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) VASP_tetra PF08776.11 EFC37246.1 - 5.3 6.7 12.0 0.71 9.5 3.1 3.3 3 0 0 3 3 3 0 VASP tetramerisation domain SBBP PF06739.11 EFC37247.1 - 0.022 14.8 0.0 0.066 13.2 0.0 1.9 1 0 0 1 1 1 0 Beta-propeller repeat Reg_prop PF07494.11 EFC37247.1 - 0.18 12.1 5.2 58 4.4 0.1 5.1 6 0 0 6 6 6 0 Two component regulator propeller RWP-RK PF02042.15 EFC37248.1 - 2.6e-07 30.5 0.1 9.4e-07 28.7 0.0 1.9 2 0 0 2 2 2 1 RWP-RK domain DUF4116 PF13475.6 EFC37249.1 - 7.3e-16 57.6 13.0 0.00016 21.3 0.5 6.0 2 2 5 7 7 7 5 Domain of unknown function (DUF4116) SMI1_KNR4 PF09346.10 EFC37249.1 - 0.00026 21.4 0.2 0.00085 19.7 0.1 1.9 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_6 PF14568.6 EFC37249.1 - 0.0019 18.6 0.4 0.02 15.3 0.0 2.5 2 0 0 2 2 2 1 SMI1-KNR4 cell-wall ATS PF15445.6 EFC37250.1 - 0.084 12.3 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 acidic terminal segments, variant surface antigen of PfEMP1 Hemerythrin PF01814.23 EFC37251.1 - 8.9e-15 55.5 3.4 1.2e-13 51.8 3.4 2.1 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain ScdA_N PF04405.14 EFC37251.1 - 1e-07 31.5 0.0 2.4e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Domain of Unknown function (DUF542) Cullin PF00888.22 EFC37252.1 - 7.1e-132 441.1 40.8 3.8e-125 418.9 25.4 2.3 2 1 1 3 3 3 2 Cullin family Cullin_Nedd8 PF10557.9 EFC37252.1 - 1.3e-25 89.2 2.0 1.3e-25 89.2 2.0 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain HbrB PF08539.11 EFC37252.1 - 0.0086 16.1 2.8 0.009 16.0 1.0 2.0 2 0 0 2 2 2 1 HbrB-like 2OG-FeII_Oxy_3 PF13640.6 EFC37253.1 - 5.5e-14 52.8 0.0 1.3e-13 51.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EFC37253.1 - 9.3e-05 22.2 0.1 0.00031 20.6 0.1 2.0 1 0 0 1 1 1 1 F-box-like Pox_C4_C10 PF03336.13 EFC37253.1 - 0.00046 19.4 0.0 0.00046 19.4 0.0 2.2 3 0 0 3 3 3 1 Poxvirus C4/C10 protein 2OG-FeII_Oxy_4 PF13661.6 EFC37253.1 - 0.0014 19.2 0.0 0.0033 18.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PRANC PF09372.10 EFC37253.1 - 0.0018 18.5 0.2 0.02 15.2 0.2 2.7 1 1 1 2 2 2 1 PRANC domain 2OG-FeII_Oxy PF03171.20 EFC37253.1 - 0.0049 17.3 0.0 0.013 16.0 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box PF00646.33 EFC37253.1 - 0.048 13.6 0.2 0.048 13.6 0.2 3.2 4 0 0 4 4 4 0 F-box domain DUF4116 PF13475.6 EFC37254.1 - 6.6e-87 285.1 0.6 2.5e-20 71.9 0.0 4.6 2 1 4 6 6 6 6 Domain of unknown function (DUF4116) DUF1667 PF07892.11 EFC37254.1 - 0.00019 21.4 0.4 6.1 7.0 0.0 4.0 1 1 2 4 4 4 2 Protein of unknown function (DUF1667) zf_C2H2_6 PF18450.1 EFC37254.1 - 0.0026 17.4 0.5 0.42 10.4 0.1 3.2 3 0 0 3 3 3 1 Zinc Finger domain DUF4853 PF16145.5 EFC37254.1 - 0.014 15.5 0.0 0.3 11.2 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4853) SIMPL PF04402.14 EFC37254.1 - 0.018 15.5 2.3 0.9 9.9 0.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF541) CbiG_C PF01890.16 EFC37254.1 - 0.025 15.1 1.0 4 8.0 0.1 2.4 1 1 1 2 2 2 0 Cobalamin synthesis G C-terminus F420_oxidored PF03807.17 EFC37254.1 - 0.75 10.4 2.8 16 6.2 0.8 2.8 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SURF6 PF04935.12 EFC37255.1 - 0.062 13.1 1.5 0.075 12.8 0.3 1.7 1 1 1 2 2 2 0 Surfeit locus protein 6 TMEM192 PF14802.6 EFC37255.1 - 0.068 12.3 1.4 0.1 11.7 1.4 1.4 1 0 0 1 1 1 0 TMEM192 family DUF4446 PF14584.6 EFC37255.1 - 3.4 7.6 6.2 3.8 7.5 4.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4291 PF14124.6 EFC37256.1 - 4.3e-43 147.3 2.4 2.3e-41 141.6 2.4 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4291) DUF4116 PF13475.6 EFC37257.1 - 2.2e-95 312.2 29.9 6e-16 57.9 0.1 11.2 5 2 5 12 12 12 12 Domain of unknown function (DUF4116) GABP-alpha PF11620.8 EFC37257.1 - 0.0031 17.7 0.4 7.3 6.9 0.0 3.9 4 0 0 4 4 4 1 GA-binding protein alpha chain DUF1667 PF07892.11 EFC37257.1 - 0.0042 17.1 0.1 24 5.1 0.0 4.6 3 2 1 4 4 4 1 Protein of unknown function (DUF1667) DUF3741 PF12552.8 EFC37257.1 - 0.028 14.4 0.3 0.78 9.7 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3741) DUF1800 PF08811.11 EFC37257.1 - 0.24 10.4 1.8 0.42 9.6 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) DUF3523 PF12037.8 EFC37257.1 - 0.34 10.3 3.8 23 4.3 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3523) NHL PF01436.21 EFC37258.1 - 1.8e-21 75.0 10.6 0.0019 18.1 0.1 6.5 7 0 0 7 7 7 5 NHL repeat zf-B_box PF00643.24 EFC37258.1 - 2.1e-06 27.8 2.4 2.1e-06 27.8 2.4 3.3 2 0 0 2 2 2 1 B-box zinc finger DUF5128 PF17170.4 EFC37258.1 - 0.00014 21.2 3.5 0.025 13.7 0.0 2.8 3 0 0 3 3 3 2 6-bladed beta-propeller FYVE_2 PF02318.16 EFC37258.1 - 0.0089 16.2 2.5 0.0089 16.2 2.5 3.6 2 1 1 3 3 3 2 FYVE-type zinc finger Apolipoprotein PF01442.18 EFC37258.1 - 0.022 14.6 3.4 0.037 13.9 3.4 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Lactonase PF10282.9 EFC37258.1 - 0.067 12.4 0.0 0.79 8.9 0.0 2.2 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller SICA_alpha PF12887.7 EFC37258.1 - 0.16 11.8 3.1 0.22 11.4 2.1 1.7 1 1 1 2 2 2 0 SICA extracellular alpha domain DUF745 PF05335.13 EFC37258.1 - 0.39 10.4 1.3 0.86 9.3 1.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Fib_alpha PF08702.10 EFC37258.1 - 1.1 9.4 8.4 0.33 11.1 5.2 1.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Gp-FAR-1 PF05823.12 EFC37258.1 - 2.2 8.7 5.5 1.2 9.5 2.9 1.8 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) TraE PF05309.11 EFC37261.1 - 0.23 10.8 2.3 1.1 8.6 0.4 2.0 2 0 0 2 2 2 0 TraE protein DUF4587 PF15248.6 EFC37263.1 - 0.052 14.3 3.9 0.052 14.3 3.9 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4587) bMG10 PF17973.1 EFC37264.1 - 4.2e-34 117.5 0.0 9.7e-34 116.4 0.0 1.7 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_BRD PF07703.14 EFC37264.1 - 8.4e-17 61.8 0.3 1.4e-15 57.9 0.0 3.2 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EFC37264.1 - 3.2e-16 58.9 0.0 4.5e-15 55.3 0.0 3.0 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFC37264.1 - 2e-15 57.0 0.0 3.9e-14 52.9 0.0 3.1 3 0 0 3 3 3 1 MG2 domain Big_5 PF13205.6 EFC37264.1 - 4e-07 30.7 2.0 0.0003 21.4 0.0 4.3 3 0 0 3 3 3 1 Bacterial Ig-like domain MG4 PF17789.1 EFC37264.1 - 0.0077 16.4 4.7 0.046 13.9 0.1 4.0 6 0 0 6 6 6 1 Macroglobulin domain MG4 TED_complement PF07678.14 EFC37264.1 - 0.0094 15.0 2.3 0.075 12.1 0.0 2.5 2 1 1 3 3 3 1 A-macroglobulin TED domain DUF11 PF01345.18 EFC37264.1 - 0.016 15.5 0.0 0.31 11.4 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function DUF11 Big_1 PF02369.16 EFC37264.1 - 0.023 14.7 7.1 17 5.5 0.0 5.9 7 0 0 7 7 7 0 Bacterial Ig-like domain (group 1) LRR_6 PF13516.6 EFC37265.1 - 3.6e-45 148.2 24.2 0.00037 20.3 0.1 13.2 13 0 0 13 13 13 10 Leucine Rich repeat LRR_8 PF13855.6 EFC37265.1 - 1.1e-29 102.0 18.0 2.3e-07 30.5 0.2 6.3 5 1 3 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EFC37265.1 - 1.3e-22 79.4 31.2 0.00014 22.2 0.4 8.7 2 2 5 10 10 10 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37265.1 - 3.1e-11 42.2 5.7 9.8 7.2 0.1 10.5 11 1 0 11 11 10 1 Leucine Rich Repeat PapC_C PF13953.6 EFC37265.1 - 0.022 14.6 0.3 41 4.1 0.0 4.2 4 1 0 4 4 4 0 PapC C-terminal domain YjcQ PF09639.10 EFC37265.1 - 0.046 13.9 8.2 0.069 13.4 0.5 3.7 2 1 0 3 3 3 0 YjcQ protein DUF4869 PF16163.5 EFC37265.1 - 0.067 12.9 6.1 1.1 9.0 0.1 3.8 1 1 3 5 5 5 0 Domain of unknown function (DUF4869) DUF2947 PF11163.8 EFC37265.1 - 0.13 12.2 0.4 11 5.9 0.1 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF2947) PulA_N1 PF17999.1 EFC37265.1 - 2 9.2 7.2 11 6.8 0.2 4.4 4 2 1 5 5 5 0 Pullulanase N1-terminal domain ApoB100_C PF12491.8 EFC37265.1 - 2.6 8.1 6.1 64 3.6 0.0 5.1 5 1 0 5 5 5 0 Apolipoprotein B100 C terminal NKWYS PF10364.9 EFC37265.1 - 2.9 8.0 7.7 1.2 9.3 1.2 3.2 2 1 1 3 3 3 0 Putative capsular polysaccharide synthesis protein Ribosomal_S30 PF04758.14 EFC37266.1 - 0.0082 16.3 0.2 0.0082 16.3 0.2 2.0 2 1 0 2 2 2 1 Ribosomal protein S30 Bromo_TP_like PF17027.5 EFC37266.1 - 0.096 12.8 1.7 0.13 12.4 1.7 1.3 1 1 0 1 1 1 0 Histone-fold protein TPR_1 PF00515.28 EFC37267.1 - 5.6e-08 32.3 0.2 0.0018 18.0 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37267.1 - 9.8e-08 31.6 0.1 0.00027 20.8 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37267.1 - 0.00022 21.8 0.0 0.0004 21.0 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC37267.1 - 0.0003 20.9 0.0 0.00061 19.9 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37267.1 - 0.0013 18.4 0.0 0.0034 17.0 0.0 1.8 1 0 0 1 1 1 1 TPR repeat TPR_17 PF13431.6 EFC37267.1 - 0.0035 17.6 0.2 0.015 15.6 0.2 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC37267.1 - 0.0042 17.2 0.1 0.36 11.2 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37267.1 - 0.0054 17.0 0.1 0.087 13.1 0.2 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC37267.1 - 0.014 15.9 0.0 0.031 14.8 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37267.1 - 0.055 14.1 0.1 0.61 10.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC37267.1 - 0.082 13.1 0.1 0.27 11.5 0.1 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFC37267.1 - 0.12 13.3 0.1 0.48 11.4 0.0 2.0 2 1 0 2 2 1 0 Tetratricopeptide repeat p450 PF00067.22 EFC37268.1 - 1.3e-87 294.5 0.5 2.2e-87 293.7 0.5 1.2 1 0 0 1 1 1 1 Cytochrome P450 TMEM151 PF14857.6 EFC37268.1 - 1.1e-06 27.9 1.5 1.7e-06 27.3 1.5 1.2 1 0 0 1 1 1 1 TMEM151 family MVP_shoulder PF11978.8 EFC37269.1 - 8.9e-34 116.0 0.7 2.8e-33 114.4 0.2 2.1 2 0 0 2 2 2 1 Shoulder domain Vault_3 PF17795.1 EFC37269.1 - 1.4e-16 60.3 0.5 8.6e-09 35.3 0.0 4.6 4 0 0 4 4 4 3 Major Vault Protein Repeat domain Vault_4 PF17796.1 EFC37269.1 - 1.4e-09 37.8 0.2 6.4e-08 32.6 0.1 3.3 3 0 0 3 3 3 1 Major Vault Protein repeat domain Vault PF01505.18 EFC37269.1 - 5e-08 33.0 0.3 6.6e-07 29.4 0.0 3.1 4 1 1 5 5 5 1 Major Vault Protein repeat domain Lipocalin_9 PF17186.4 EFC37269.1 - 0.0072 16.6 0.5 0.019 15.3 0.5 1.6 1 0 0 1 1 1 1 Lipocalin-like domain TPR_1 PF00515.28 EFC37270.1 - 7.5e-18 63.5 14.4 6.5e-06 25.7 0.7 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37270.1 - 6.7e-15 53.9 10.5 1.1e-05 25.2 0.2 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37270.1 - 1.1e-09 38.8 0.0 2.2e-08 34.6 0.0 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37270.1 - 2.2e-09 36.8 6.4 2.3e-05 24.0 0.4 4.0 3 1 1 4 4 4 3 TPR repeat TPR_8 PF13181.6 EFC37270.1 - 8.2e-09 35.0 7.1 0.011 15.9 0.7 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37270.1 - 9.2e-08 32.3 3.2 0.034 14.8 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC37270.1 - 1.5e-07 31.3 6.4 0.00012 22.2 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC37270.1 - 6.8e-07 29.3 0.0 0.00013 22.1 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37270.1 - 0.00036 20.8 0.2 1.6 9.0 0.1 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC37270.1 - 0.00049 20.7 0.0 4.4 8.4 0.0 3.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC37270.1 - 0.00051 20.5 0.0 0.006 17.1 0.0 2.6 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC37270.1 - 0.00053 20.2 2.5 0.035 14.3 1.5 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EFC37270.1 - 0.023 14.7 1.9 2.3 8.3 0.5 2.7 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Far-17a_AIG1 PF04750.14 EFC37271.1 - 8.5e-17 61.1 18.2 1e-16 60.9 18.2 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein COA2 PF17051.5 EFC37271.1 - 0.2 11.7 0.1 0.45 10.6 0.1 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase assembly factor 2 Band_7 PF01145.25 EFC37272.1 - 3.8e-14 53.1 0.0 3.8e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 SPFH domain / Band 7 family AAA_22 PF13401.6 EFC37273.1 - 3e-06 27.6 0.0 8.4e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFC37273.1 - 1.9e-05 24.7 0.0 4.6e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC37273.1 - 4.9e-05 23.8 0.3 0.014 15.7 0.3 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EFC37273.1 - 6.5e-05 23.1 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC37273.1 - 0.00042 20.1 0.1 0.0016 18.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC37273.1 - 0.0038 17.6 0.1 0.019 15.4 0.0 2.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EFC37273.1 - 0.013 14.7 0.0 0.027 13.7 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 EFC37273.1 - 0.019 14.5 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EFC37273.1 - 0.097 12.6 4.0 0.49 10.3 0.7 2.9 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea DUF4116 PF13475.6 EFC37274.1 - 9.4e-48 159.7 19.8 2.4e-12 46.4 0.3 9.0 3 2 7 10 10 10 9 Domain of unknown function (DUF4116) LRR_6 PF13516.6 EFC37275.1 - 1.4e-52 171.3 23.1 1.1e-05 25.0 0.1 8.5 8 0 0 8 8 8 8 Leucine Rich repeat LRR_8 PF13855.6 EFC37275.1 - 2.1e-26 91.4 43.1 1.7e-08 34.1 2.5 4.4 2 1 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC37275.1 - 4.2e-24 84.2 56.3 1.4e-05 25.3 2.2 6.2 2 1 7 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37275.1 - 2e-12 45.8 13.4 2.1 9.2 0.1 9.1 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC37275.1 - 2.2e-07 30.6 9.6 0.00051 19.6 0.8 3.8 1 1 2 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC37275.1 - 0.00048 20.0 0.9 54 3.6 0.0 5.2 1 1 3 5 5 5 0 Domain of unknown function (DUF4347) CLU_N PF15044.6 EFC37275.1 - 0.16 12.3 17.1 16 6.0 0.2 6.0 4 1 4 8 8 8 0 Mitochondrial function, CLU-N-term bZIP_C PF12498.8 EFC37275.1 - 0.21 12.6 2.3 2.5 9.1 0.5 3.0 1 1 3 4 4 4 0 Basic leucine-zipper C terminal RSN1_7TM PF02714.15 EFC37276.1 - 2.2e-24 86.2 17.4 2.2e-24 86.2 17.4 3.2 4 0 0 4 4 4 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFC37276.1 - 6.2e-07 29.3 1.2 8.3e-06 25.7 0.9 4.9 5 1 1 6 6 6 2 Late exocytosis, associated with Golgi transport FAM176 PF14851.6 EFC37276.1 - 0.00086 19.0 1.5 0.095 12.4 0.2 3.1 3 0 0 3 3 3 1 FAM176 family FAM163 PF15069.6 EFC37276.1 - 0.15 12.5 0.1 0.4 11.1 0.1 1.7 1 0 0 1 1 1 0 FAM163 family FA_hydroxylase PF04116.13 EFC37276.1 - 0.47 10.8 8.7 1.2 9.4 4.0 3.8 3 0 0 3 3 3 0 Fatty acid hydroxylase superfamily DMAP_binding PF06464.11 EFC37276.1 - 5.8 7.8 10.3 1.4 9.7 5.6 2.3 2 0 0 2 2 2 0 DMAP1-binding Domain DUF4131 PF13567.6 EFC37276.1 - 9.8 5.8 8.3 4.6 6.9 0.9 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) OAD_gamma PF04277.13 EFC37277.1 - 0.11 13.1 0.0 0.4 11.3 0.0 2.0 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain BTB PF00651.31 EFC37278.1 - 2.9e-10 40.3 0.1 1.4e-09 38.1 0.1 2.3 1 0 0 1 1 1 1 BTB/POZ domain F-box-like PF12937.7 EFC37278.1 - 8.5e-06 25.6 0.9 4.1e-05 23.4 0.1 2.6 2 0 0 2 2 2 1 F-box-like KASH_CCD PF14662.6 EFC37278.1 - 0.00025 20.9 11.6 0.00025 20.9 11.6 2.4 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH F-box PF00646.33 EFC37278.1 - 0.11 12.4 0.1 0.62 10.0 0.0 2.4 2 0 0 2 2 2 0 F-box domain bZIP_1 PF00170.21 EFC37278.1 - 1.7 8.8 5.6 1.9 8.7 2.8 2.6 1 1 1 2 2 2 0 bZIP transcription factor DUF641 PF04859.12 EFC37278.1 - 5.5 7.3 10.7 4.4 7.7 8.0 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Ank_2 PF12796.7 EFC37280.1 - 1.2e-15 57.9 0.0 2.2e-09 37.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC37280.1 - 1.9e-13 49.3 0.0 0.0092 16.4 0.0 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFC37280.1 - 3.3e-12 46.7 0.0 6.2e-07 29.9 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC37280.1 - 2e-07 31.1 0.0 0.8 10.3 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EFC37280.1 - 2.5e-06 27.6 0.0 0.33 11.3 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) DCB PF16213.5 EFC37280.1 - 0.089 12.5 0.1 3.2 7.4 0.0 2.1 1 1 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 ABC_membrane PF00664.23 EFC37281.1 - 1.4e-49 169.3 20.3 1.9e-49 168.8 20.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC37281.1 - 4.2e-35 121.2 0.0 8.3e-35 120.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC37281.1 - 6.8e-06 25.7 1.5 0.0023 17.4 1.5 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC37281.1 - 0.00031 21.1 0.0 0.001 19.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC37281.1 - 0.0012 18.5 0.2 0.0034 17.1 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFC37281.1 - 0.0066 16.7 0.4 0.05 13.9 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC37281.1 - 0.015 15.7 0.1 0.6 10.5 0.1 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFC37281.1 - 0.017 15.0 0.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain ABC_ATPase PF09818.9 EFC37281.1 - 0.018 13.8 0.0 0.034 12.9 0.0 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 EFC37281.1 - 0.02 14.6 0.0 0.075 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC37281.1 - 0.029 14.9 0.0 0.059 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFC37281.1 - 0.035 13.4 0.0 0.081 12.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 EFC37281.1 - 0.039 13.9 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 EFC37281.1 - 0.04 13.7 0.0 0.63 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EFC37281.1 - 0.067 13.2 0.0 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 EFC37281.1 - 0.16 12.3 0.2 0.96 9.7 0.2 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FeoB_C PF07664.12 EFC37281.1 - 0.45 10.2 2.9 21 4.9 2.3 3.6 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus DUF2614 PF11023.8 EFC37281.1 - 4.3 7.5 7.9 0.27 11.3 2.5 1.8 2 0 0 2 2 1 0 Zinc-ribbon containing domain Zn_clus PF00172.18 EFC37282.1 - 8.8e-07 28.9 10.9 1.5e-06 28.2 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MORN PF02493.20 EFC37283.1 - 5.4e-09 35.4 34.5 8.2e-05 22.3 1.6 7.6 8 0 0 8 8 8 3 MORN repeat CS PF04969.16 EFC37283.1 - 2.9e-06 28.2 1.2 5.8e-06 27.2 1.2 1.5 1 0 0 1 1 1 1 CS domain Presenilin PF01080.17 EFC37283.1 - 0.43 9.3 3.0 0.79 8.4 3.0 1.5 1 1 0 1 1 1 0 Presenilin FAM176 PF14851.6 EFC37283.1 - 1.1 8.9 17.6 11 5.7 2.2 4.0 4 0 0 4 4 4 0 FAM176 family RdRP PF05183.12 EFC37285.1 - 3.3e-133 445.4 0.1 4.2e-133 445.1 0.1 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Macoilin PF09726.9 EFC37286.1 - 0.08 11.5 5.2 0.072 11.6 5.2 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EFC37286.1 - 1.3 7.7 2.8 1.3 7.7 2.8 1.1 1 0 0 1 1 1 0 Presenilin NST1 PF13945.6 EFC37286.1 - 9.4 6.3 11.1 14 5.7 11.1 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator ART PF01129.18 EFC37287.1 - 0.0027 17.1 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase ADPrib_exo_Tox PF03496.14 EFC37287.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme DUF4116 PF13475.6 EFC37288.1 - 5.7e-53 176.4 29.3 1.1e-13 50.6 0.2 10.6 4 2 6 13 13 13 11 Domain of unknown function (DUF4116) MTTB PF06253.11 EFC37288.1 - 0.058 11.4 0.0 0.12 10.3 0.0 1.5 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Rad17 PF03215.15 EFC37288.1 - 0.26 11.2 2.7 16 5.3 0.1 3.5 3 1 1 4 4 4 0 Rad17 P-loop domain DTHCT PF08070.11 EFC37290.1 - 5.6 7.8 11.3 0.11 13.3 4.1 1.8 2 0 0 2 2 2 0 DTHCT (NUC029) region Pkinase PF00069.25 EFC37291.1 - 1.5e-14 54.0 1.3 3.7e-14 52.7 1.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37291.1 - 4.4e-07 29.5 0.2 1.2e-06 28.0 0.1 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase HEPN_Swt1 PF18731.1 EFC37291.1 - 0.031 14.6 0.0 2 8.8 0.0 2.5 2 0 0 2 2 2 0 Swt1-like HEPN ANAPC_CDC26 PF10471.9 EFC37292.1 - 0.024 15.5 4.0 0.047 14.5 4.0 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 NARP1 PF12569.8 EFC37292.1 - 0.1 11.5 4.5 0.12 11.3 4.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 NABP PF07990.12 EFC37292.1 - 0.19 11.3 3.1 0.21 11.1 3.1 1.0 1 0 0 1 1 1 0 Nucleic acid binding protein NABP INO80_Ies4 PF08193.11 EFC37292.1 - 0.34 10.9 6.3 0.4 10.7 6.3 1.1 1 0 0 1 1 1 0 INO80 complex subunit Ies4 DUF1068 PF06364.12 EFC37292.1 - 1.1 9.1 5.7 1.6 8.6 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) NMO PF03060.15 EFC37293.1 - 9.6e-72 242.1 0.0 1.1e-71 242.0 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 EFC37293.1 - 1.2e-12 47.5 0.2 2.3e-10 40.0 0.2 2.1 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain DUF561 PF04481.12 EFC37293.1 - 5.1e-08 32.4 2.0 6.7e-08 32.0 0.6 1.8 2 1 1 3 3 3 1 Protein of unknown function (DUF561) DHO_dh PF01180.21 EFC37293.1 - 2.2e-05 23.9 0.1 2.9e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 EFC37293.1 - 9.8e-05 21.9 0.3 0.00037 20.0 0.3 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein FMN_dh PF01070.18 EFC37293.1 - 0.00025 20.2 1.1 0.00042 19.5 0.2 1.7 2 0 0 2 2 2 1 FMN-dependent dehydrogenase ThiG PF05690.14 EFC37293.1 - 0.00035 20.0 0.1 0.00058 19.2 0.1 1.3 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG NanE PF04131.14 EFC37293.1 - 0.00057 19.1 0.1 0.0011 18.2 0.1 1.4 1 0 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase TMP-TENI PF02581.17 EFC37293.1 - 0.0063 15.9 0.8 0.02 14.2 0.8 1.8 1 1 0 1 1 1 1 Thiamine monophosphate synthase PEP_hydrolase PF09370.10 EFC37293.1 - 0.0078 15.5 0.2 1.4 8.1 0.2 2.1 2 0 0 2 2 2 2 Phosphoenolpyruvate hydrolase-like G3P_antiterm PF04309.12 EFC37293.1 - 0.015 14.7 0.1 0.029 13.8 0.1 1.4 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator IF2_N PF04760.15 EFC37293.1 - 0.031 14.1 0.3 1.9 8.4 0.0 3.4 4 0 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region Dus PF01207.17 EFC37293.1 - 0.12 11.4 0.1 0.48 9.5 0.0 1.9 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) VASP_tetra PF08776.11 EFC37293.1 - 5.2 6.7 12.0 0.71 9.5 3.1 3.3 3 0 0 3 3 3 0 VASP tetramerisation domain Gp_dh_C PF02800.20 EFC37294.1 - 6.2e-35 120.1 0.6 1.2e-34 119.2 0.6 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PH PF00169.29 EFC37294.1 - 3.6e-17 62.8 0.5 8.5e-17 61.6 0.5 1.6 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 EFC37294.1 - 2.3e-08 34.4 0.7 5e-08 33.3 0.7 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFC37294.1 - 2.1e-05 24.9 0.7 2.1e-05 24.9 0.7 2.9 3 0 0 3 3 3 1 Pleckstrin homology domain PH_6 PF15406.6 EFC37294.1 - 0.0032 17.8 0.3 0.042 14.1 0.0 2.7 3 0 0 3 3 3 1 Pleckstrin homology domain Mvb12 PF09452.10 EFC37294.1 - 0.055 13.9 0.3 0.2 12.1 0.3 2.0 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 PH_8 PF15409.6 EFC37294.1 - 0.13 12.5 5.7 0.11 12.8 2.4 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain ALMT PF11744.8 EFC37295.1 - 7.9 5.2 9.9 9.6 4.9 9.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NTP_transf_2 PF01909.23 EFC37296.1 - 0.0003 21.0 0.0 0.00088 19.5 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFC37296.1 - 0.0031 17.6 0.7 0.0031 17.6 0.7 3.0 2 1 1 3 3 3 1 Polymerase beta, Nucleotidyltransferase RlaP PF10127.9 EFC37296.1 - 0.058 13.0 0.0 0.47 10.0 0.0 2.1 2 0 0 2 2 2 0 RNA repair pathway DNA polymerase beta family Glycolytic PF00274.19 EFC37297.1 - 2.9e-144 480.1 0.4 3.3e-144 479.9 0.4 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I Sod_Fe_C PF02777.18 EFC37298.1 - 1.4e-37 127.9 0.9 3.5e-37 126.7 0.3 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFC37298.1 - 5.1e-25 87.8 2.1 9.4e-25 86.9 2.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF5617 PF18493.1 EFC37298.1 - 0.068 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) DUF4116 PF13475.6 EFC37299.1 - 0.0073 16.0 6.6 0.014 15.1 3.1 2.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4116) Mistic PF11458.8 EFC37299.1 - 0.12 12.4 5.2 0.075 13.0 3.1 1.7 2 0 0 2 2 2 0 Membrane-integrating protein Mistic TrmE_N PF10396.9 EFC37299.1 - 0.14 12.5 0.1 0.36 11.2 0.0 1.8 2 1 0 2 2 2 0 GTP-binding protein TrmE N-terminus RNA_ligase PF09414.10 EFC37301.1 - 1.9e-28 99.8 0.1 3.3e-28 99.0 0.1 1.4 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_M PF01068.21 EFC37301.1 - 0.012 15.3 0.2 0.11 12.2 0.2 2.3 1 1 0 1 1 1 0 ATP dependent DNA ligase domain AHJR-like PF18743.1 EFC37301.1 - 0.07 12.7 0.0 5.7 6.5 0.0 2.2 2 0 0 2 2 2 0 REase_AHJR-like RNA_lig_T4_1 PF09511.10 EFC37301.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 1 0 1 1 1 0 RNA ligase Ank_5 PF13857.6 EFC37302.1 - 1.3e-07 31.8 0.0 0.00027 21.2 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC37302.1 - 2.8e-06 27.8 0.0 9.7e-06 26.0 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC37302.1 - 0.00019 21.6 0.2 0.0066 16.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EFC37302.1 - 0.00025 21.6 0.0 0.0015 19.1 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC37302.1 - 0.0013 19.1 0.0 0.0069 16.8 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat DUF3447 PF11929.8 EFC37302.1 - 2.1 8.4 7.3 2.1 8.3 0.0 4.0 4 1 0 4 4 4 0 Domain of unknown function (DUF3447) SBBP PF06739.11 EFC37303.1 - 0.00034 20.5 0.0 0.00066 19.6 0.0 1.5 1 0 0 1 1 1 1 Beta-propeller repeat NHL PF01436.21 EFC37303.1 - 0.00096 19.1 0.0 0.0022 17.9 0.0 1.6 1 0 0 1 1 1 1 NHL repeat PPP1R32 PF15691.5 EFC37304.1 - 0.14 11.2 0.0 0.21 10.6 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 32 Peptidase_M1 PF01433.20 EFC37305.1 - 1.3e-42 145.9 0.4 2.6e-42 144.9 0.4 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 EFC37305.1 - 5.6e-38 129.5 0.5 1.6e-37 128.0 0.5 1.9 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 EFC37305.1 - 6.2e-22 78.7 5.7 8.1e-21 75.0 5.7 2.3 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 EFC37305.1 - 0.046 14.1 0.7 1 9.8 0.7 2.7 1 1 0 1 1 1 0 M61 glycyl aminopeptidase RGS PF00615.19 EFC37306.1 - 2e-16 60.3 11.7 4e-16 59.3 9.2 2.5 2 1 0 2 2 2 1 Regulator of G protein signaling domain START PF01852.19 EFC37306.1 - 3.1e-06 26.7 0.0 5.6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 START domain Tfb5 PF06331.12 EFC37306.1 - 0.045 13.7 0.2 0.14 12.2 0.2 1.8 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 SR-25 PF10500.9 EFC37306.1 - 0.47 10.0 9.4 0.8 9.3 9.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 EFC37306.1 - 1.5 9.4 11.4 1.1 9.9 7.8 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Ras PF00071.22 EFC37307.1 - 9.1e-16 57.9 0.1 3.5e-15 56.0 0.1 2.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37307.1 - 0.0014 18.8 0.1 0.0059 16.8 0.1 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase BAF1_ABF1 PF04684.13 EFC37307.1 - 0.0068 15.5 1.1 0.011 14.8 1.1 1.3 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor PAP2_3 PF14378.6 EFC37309.1 - 3.3e-12 46.5 2.6 3.3e-12 46.5 2.6 1.5 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 EFC37309.1 - 4.6e-05 23.2 2.8 4.6e-05 23.2 2.8 2.6 2 2 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 EFC37309.1 - 0.035 14.6 0.8 0.035 14.6 0.8 3.3 3 0 0 3 3 3 0 PAP2 superfamily C-terminal TRAM1 PF08390.11 EFC37309.1 - 0.2 11.3 0.0 0.2 11.3 0.0 2.3 2 1 1 3 3 3 0 TRAM1-like protein DUF1129 PF06570.11 EFC37309.1 - 0.41 10.1 3.3 0.84 9.1 3.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) DUF679 PF05078.12 EFC37309.1 - 1.8 8.5 7.2 3.3 7.7 1.9 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF679) Abhydrolase_1 PF00561.20 EFC37310.1 - 1.1e-15 58.0 0.0 5.3e-12 45.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC37310.1 - 1e-11 45.9 0.0 1.5e-11 45.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC37310.1 - 3.7e-05 23.1 0.0 0.0039 16.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 EFC37310.1 - 0.055 13.1 0.0 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 EFC37310.1 - 0.094 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein CHASE4 PF05228.13 EFC37311.1 - 2.5e-10 40.7 0.0 5.6e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 CHASE4 domain RGS PF00615.19 EFC37311.1 - 6.8e-10 39.3 5.6 6.8e-10 39.3 5.6 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain HAMP PF00672.25 EFC37311.1 - 0.00038 20.8 0.0 0.00078 19.8 0.0 1.5 1 0 0 1 1 1 1 HAMP domain PAS_9 PF13426.7 EFC37311.1 - 0.0015 18.7 0.2 0.0057 16.9 0.2 2.1 1 0 0 1 1 1 1 PAS domain s48_45 PF07422.13 EFC37311.1 - 0.02 15.4 2.6 1.3 9.7 0.1 3.2 2 0 0 2 2 2 0 Sexual stage antigen s48/45 domain PAS PF00989.25 EFC37311.1 - 0.024 14.7 0.3 0.095 12.7 0.0 2.2 2 1 0 2 2 2 0 PAS fold NS3_envE PF02723.14 EFC37311.1 - 5.1 7.2 8.8 8.3 6.6 3.0 2.5 2 0 0 2 2 2 0 Non-structural protein NS3/Small envelope protein E LRR_6 PF13516.6 EFC37312.1 - 6.1e-07 29.0 7.9 0.24 11.6 0.1 5.2 4 0 0 4 4 4 3 Leucine Rich repeat LRR_4 PF12799.7 EFC37312.1 - 0.00017 21.9 19.2 0.22 12.0 1.5 6.1 2 2 4 6 6 6 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC37313.1 - 0.0018 18.1 0.0 0.0049 16.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37313.1 - 0.048 13.6 1.5 0.52 10.3 0.0 3.3 3 0 0 3 3 3 0 F-box domain LRR_8 PF13855.6 EFC37313.1 - 0.52 10.1 13.0 5.9 6.7 0.0 4.7 4 1 1 5 5 5 0 Leucine rich repeat SUR7 PF06687.12 EFC37315.1 - 0.0011 18.7 0.7 0.0011 18.6 0.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family Pex14_N PF04695.13 EFC37315.1 - 0.13 12.9 1.9 0.18 12.4 1.9 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glucan_synthase PF02364.15 EFC37315.1 - 0.16 10.1 3.7 0.18 9.9 3.7 1.0 1 0 0 1 1 1 0 1,3-beta-glucan synthase component FtsX PF02687.21 EFC37315.1 - 1.8 9.1 9.3 2.4 8.7 9.3 1.1 1 0 0 1 1 1 0 FtsX-like permease family Hydrolase_4 PF12146.8 EFC37316.1 - 0.00023 20.5 0.0 0.00044 19.6 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EFC37316.1 - 0.098 12.4 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein TPR_1 PF00515.28 EFC37317.1 - 7e-35 117.4 10.2 0.00029 20.5 0.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37317.1 - 1.6e-24 84.0 8.3 0.0018 18.2 0.0 10.0 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC37317.1 - 1.4e-20 71.7 14.2 0.26 11.6 0.3 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37317.1 - 3.1e-20 71.6 10.8 0.00011 21.8 0.1 7.9 6 2 3 9 9 9 4 TPR repeat TPR_17 PF13431.6 EFC37317.1 - 1.1e-19 69.3 4.9 0.0008 19.6 0.1 7.2 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_9 PF13371.6 EFC37317.1 - 1.2e-14 54.2 0.0 0.00019 21.5 0.0 4.9 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37317.1 - 5.9e-13 48.9 4.0 0.083 13.2 0.0 6.5 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFC37317.1 - 3.1e-12 46.2 0.3 0.0095 16.7 0.1 6.2 5 3 2 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37317.1 - 2.3e-10 40.9 3.3 2.3e-05 24.9 0.0 5.1 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37317.1 - 9.7e-10 38.5 4.9 0.025 15.2 0.0 7.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC37317.1 - 5.9e-07 29.9 6.2 0.024 15.2 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC37317.1 - 0.00011 22.0 0.2 9.4 6.5 0.0 6.0 5 2 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC37317.1 - 0.0055 16.9 1.9 0.51 10.6 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EFC37317.1 - 0.006 16.9 3.6 1.2 9.5 0.0 3.2 3 0 0 3 3 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC37317.1 - 0.0065 16.5 6.8 1 9.4 0.0 4.3 5 1 1 6 6 4 2 Fis1 C-terminal tetratricopeptide repeat DUF357 PF04010.13 EFC37317.1 - 0.029 14.4 1.8 2.4 8.3 0.0 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF357) PTS_IIA PF02255.16 EFC37317.1 - 3.3 7.8 5.6 2.8 8.1 0.1 3.4 4 0 0 4 4 4 0 PTS system, Lactose/Cellobiose specific IIA subunit Sec8_exocyst PF04048.14 EFC37318.1 - 2.7e-13 50.0 3.7 2.7e-13 50.0 3.7 2.8 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain Ribosomal_L27A PF00828.19 EFC37319.1 - 7.7e-20 71.9 0.2 9.7e-20 71.5 0.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A APC_u13 PF16634.5 EFC37320.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr and SAMP PhoLip_ATPase_C PF16212.5 EFC37321.1 - 1.2e-62 212.0 13.4 1.2e-62 212.0 13.4 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC37321.1 - 1.6e-22 78.9 1.2 4.7e-22 77.4 1.2 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFC37321.1 - 4.4e-17 62.0 0.9 5.2e-15 55.3 0.0 2.9 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC37321.1 - 4.3e-13 50.0 0.2 5.5e-08 33.3 0.0 3.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFC37321.1 - 1.4e-08 34.5 0.9 1.4e-08 34.5 0.9 2.9 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFC37321.1 - 0.00019 21.2 0.5 0.00019 21.2 0.5 3.0 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase SRTM1 PF15872.5 EFC37321.1 - 0.062 13.5 0.1 0.21 11.8 0.1 1.9 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 NHL PF01436.21 EFC37322.1 - 9.7e-11 41.1 7.9 0.00068 19.5 0.0 5.6 5 0 0 5 5 5 3 NHL repeat Lactonase PF10282.9 EFC37322.1 - 0.0037 16.6 0.1 0.15 11.3 0.0 2.4 2 1 0 2 2 2 1 Lactonase, 7-bladed beta-propeller DUF1028 PF06267.12 EFC37322.1 - 0.15 11.9 1.0 0.26 11.0 1.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF1028) RGS PF00615.19 EFC37323.1 - 0.0042 17.3 1.1 0.012 15.9 1.1 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Imm9 PF15587.6 EFC37323.1 - 0.042 13.5 0.1 0.099 12.3 0.1 1.6 1 0 0 1 1 1 0 Immunity protein 9 DUF2627 PF11118.8 EFC37323.1 - 1.5 9.5 6.4 16 6.2 1.5 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2627) PEN-2 PF10251.9 EFC37323.1 - 8 7.0 10.9 2.9 8.4 2.0 3.1 3 0 0 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase NHL PF01436.21 EFC37325.1 - 5.3e-33 111.4 11.1 2.5e-07 30.4 0.1 10.5 11 0 0 11 11 11 7 NHL repeat SGL PF08450.12 EFC37325.1 - 7.3e-07 29.0 1.7 0.0042 16.7 0.0 4.2 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC37325.1 - 1.8e-06 28.2 9.1 1.8e-06 28.2 9.1 2.1 2 0 0 2 2 2 1 EGF-like domain EGF PF00008.27 EFC37325.1 - 0.00043 20.5 12.4 0.00087 19.6 6.6 3.0 2 0 0 2 2 2 1 EGF-like domain SBBP PF06739.11 EFC37325.1 - 0.002 18.1 1.5 0.016 15.2 0.4 3.4 3 0 0 3 3 3 1 Beta-propeller repeat hEGF PF12661.7 EFC37325.1 - 0.0086 16.7 7.9 0.0086 16.7 7.9 3.5 3 0 0 3 3 3 1 Human growth factor-like EGF Str_synth PF03088.16 EFC37325.1 - 0.012 15.7 0.8 35 4.6 0.0 5.3 6 0 0 6 6 6 0 Strictosidine synthase Lactonase PF10282.9 EFC37325.1 - 0.046 13.0 0.0 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Laminin_EGF PF00053.24 EFC37325.1 - 0.12 12.5 6.4 0.28 11.3 6.4 1.5 1 0 0 1 1 1 0 Laminin EGF domain cEGF PF12662.7 EFC37325.1 - 0.47 10.4 7.0 2.1 8.3 3.8 3.3 2 0 0 2 2 2 0 Complement Clr-like EGF-like Peptidase_A3 PF02160.15 EFC37325.1 - 1.6 8.2 3.3 10 5.6 0.1 2.6 3 0 0 3 3 3 0 Cauliflower mosaic virus peptidase (A3) DUF4769 PF15992.5 EFC37326.1 - 0.12 12.2 1.8 0.2 11.4 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) DUF3431 PF11913.8 EFC37328.1 - 1.1e-39 136.5 3.8 2.3e-38 132.2 3.8 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3431) SOG2 PF10428.9 EFC37329.1 - 8.8 5.4 20.8 12 4.9 20.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein RrnaAD PF00398.20 EFC37330.1 - 1.4e-46 158.7 0.0 1.7e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFC37330.1 - 0.08 13.7 0.0 0.26 12.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_PK PF05891.12 EFC37330.1 - 0.11 12.0 0.1 0.75 9.3 0.1 2.2 2 1 0 2 2 2 0 AdoMet dependent proline di-methyltransferase SRP54 PF00448.22 EFC37331.1 - 1.6e-55 187.8 0.6 1.6e-53 181.3 0.6 2.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain SRP-alpha_N PF04086.13 EFC37331.1 - 3.5e-35 122.4 30.5 5.7e-35 121.7 30.5 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 EFC37331.1 - 1.8e-09 37.7 2.2 4.8e-09 36.3 0.1 2.8 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 EFC37331.1 - 1.8e-05 23.9 0.0 0.00011 21.3 0.0 2.3 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EFC37331.1 - 3.2e-05 23.3 0.0 0.00014 21.2 0.0 2.1 1 0 0 1 1 1 1 Zeta toxin RsgA_GTPase PF03193.16 EFC37331.1 - 0.0028 17.6 0.4 0.15 12.0 0.1 3.0 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFC37331.1 - 0.0028 17.9 0.1 0.013 15.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 EFC37331.1 - 0.0037 17.3 1.7 0.05 13.7 0.2 3.3 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 EFC37331.1 - 0.0074 16.5 0.5 0.03 14.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFC37331.1 - 0.0086 16.1 1.2 0.13 12.4 0.2 3.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase NTPase_1 PF03266.15 EFC37331.1 - 0.011 15.6 0.1 2.3 8.1 0.0 2.8 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 EFC37331.1 - 0.017 15.5 0.8 0.12 12.7 0.0 2.9 3 1 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EFC37331.1 - 0.03 14.0 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 EFC37331.1 - 0.037 13.8 0.2 0.51 10.1 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 EFC37331.1 - 0.092 13.1 0.0 0.29 11.5 0.0 1.9 2 0 0 2 2 1 0 AAA ATPase domain AAA_25 PF13481.6 EFC37331.1 - 0.1 12.2 0.4 9.8 5.7 0.0 3.1 2 1 0 2 2 2 0 AAA domain Mitofilin PF09731.9 EFC37331.1 - 0.27 10.1 35.0 0.47 9.2 35.0 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein AAA PF00004.29 EFC37331.1 - 0.41 11.1 0.0 0.41 11.1 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) UBA PF00627.31 EFC37332.1 - 2.3e-06 27.4 0.1 3.1e-05 23.7 0.0 2.6 2 0 0 2 2 2 1 UBA/TS-N domain HOIP-UBA PF16678.5 EFC37332.1 - 0.00032 20.7 0.3 0.0011 19.0 0.3 1.9 1 0 0 1 1 1 1 HOIP UBA domain pair UBA_3 PF09288.10 EFC37332.1 - 0.0025 17.6 0.3 1.8 8.4 0.0 3.8 4 0 0 4 4 4 1 Fungal ubiquitin-associated domain CUE PF02845.16 EFC37332.1 - 0.0036 17.0 0.4 1.8 8.3 0.1 3.1 3 0 0 3 3 3 2 CUE domain UBA_4 PF14555.6 EFC37332.1 - 0.015 15.1 0.0 0.067 13.0 0.0 2.1 1 0 0 1 1 1 0 UBA-like domain Rad60-SLD_2 PF13881.6 EFC37332.1 - 0.18 11.9 1.6 0.29 11.2 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like SSP160 PF06933.11 EFC37332.1 - 5.1 5.2 15.7 7.9 4.5 15.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Methyltransf_FA PF12248.8 EFC37333.1 - 8e-23 80.7 0.0 2e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase Cytokin_check_N PF10407.9 EFC37333.1 - 0.087 12.8 0.7 4.4 7.3 0.4 2.7 2 0 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus TFIIA PF03153.13 EFC37334.1 - 4.4 7.2 12.8 5.2 7.0 12.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit F-box_4 PF15966.5 EFC37335.1 - 0.073 13.0 0.1 0.5 10.3 0.0 2.1 1 1 1 2 2 2 0 F-box NOB1_Zn_bind PF08772.11 EFC37335.1 - 0.099 12.8 1.0 0.2 11.8 1.0 1.5 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF4577 PF15145.6 EFC37335.1 - 0.14 12.2 0.0 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) PknG_rubred PF16919.5 EFC37335.1 - 0.19 11.9 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain SUI1 PF01253.22 EFC37336.1 - 2.7e-21 75.9 0.1 7.3e-21 74.5 0.1 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 MAPEG PF01124.18 EFC37337.1 - 2.5e-14 53.3 0.0 3.4e-14 52.8 0.0 1.3 1 1 0 1 1 1 1 MAPEG family MRJP PF03022.16 EFC37338.1 - 0.00025 20.5 0.1 4.6 6.5 0.0 3.2 3 0 0 3 3 3 3 Major royal jelly protein SGL PF08450.12 EFC37338.1 - 0.027 14.0 0.0 7.2 6.1 0.0 2.3 1 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC37338.1 - 0.1 12.8 1.5 0.54 10.5 0.0 2.7 3 0 0 3 3 3 0 Arylesterase NUMOD1 PF07453.13 EFC37338.1 - 0.67 10.3 3.1 3.4 8.0 0.2 3.4 4 0 0 4 4 4 0 NUMOD1 domain RhoGEF PF00621.20 EFC37339.1 - 7.5e-46 156.7 4.3 7.5e-46 156.7 4.3 3.5 3 2 0 3 3 3 1 RhoGEF domain Chromo_2 PF18704.1 EFC37339.1 - 0.015 15.6 0.6 0.089 13.1 0.6 2.3 1 0 0 1 1 1 0 Chromatin organization modifier domain 2 SH3_9 PF14604.6 EFC37339.1 - 0.022 14.6 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain SH3_1 PF00018.28 EFC37339.1 - 0.036 13.7 0.0 0.076 12.6 0.0 1.6 1 0 0 1 1 1 0 SH3 domain LIP PF03583.14 EFC37339.1 - 0.21 10.9 0.5 2.6 7.3 0.3 2.5 2 0 0 2 2 2 0 Secretory lipase PH PF00169.29 EFC37339.1 - 5.7 7.5 8.6 0.29 11.7 0.2 3.2 4 0 0 4 4 4 0 PH domain HSP70 PF00012.20 EFC37340.1 - 1.4e-55 188.7 2.0 1.9e-54 184.9 1.2 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 EFC37340.1 - 5.6e-13 48.4 0.6 2.3e-12 46.4 0.6 1.9 1 1 0 1 1 1 1 MreB/Mbl protein Actin PF00022.19 EFC37340.1 - 6.8e-06 24.9 0.5 0.01 14.5 0.1 2.3 1 1 0 2 2 2 2 Actin PilM_2 PF11104.8 EFC37340.1 - 0.0054 15.8 0.1 0.87 8.5 0.0 2.3 2 0 0 2 2 2 2 Type IV pilus assembly protein PilM; DUF4116 PF13475.6 EFC37342.1 - 7.8e-104 339.3 18.3 5.7e-16 58.0 0.1 10.2 5 2 3 10 10 10 10 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC37342.1 - 2.4e-26 92.7 0.0 6.1e-26 91.4 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37342.1 - 1.3e-07 31.1 0.0 4.7e-07 29.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC37342.1 - 0.0069 15.2 0.0 0.014 14.2 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase DUF4853 PF16145.5 EFC37342.1 - 0.011 15.8 0.0 5.8 7.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4853) TPR_2 PF07719.17 EFC37343.1 - 0.074 13.2 2.2 25 5.3 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5537 PF17690.1 EFC37343.1 - 0.11 12.2 0.3 16 5.1 0.1 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5537) TPR_1 PF00515.28 EFC37343.1 - 1.2 9.0 3.9 29 4.7 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Methyltransf_23 PF13489.6 EFC37344.1 - 1.5e-20 73.7 0.1 2.2e-20 73.2 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC37344.1 - 1.1e-15 58.1 0.0 2.2e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC37344.1 - 1.1e-13 51.7 0.0 2.7e-13 50.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC37344.1 - 5.6e-12 45.7 0.0 1.1e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC37344.1 - 5.6e-11 43.0 0.0 1.1e-10 42.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC37344.1 - 1.1e-08 34.8 0.0 1.6e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFC37344.1 - 1.5e-06 27.9 0.1 3.7e-06 26.6 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase small domain TehB PF03848.14 EFC37344.1 - 1.4e-05 24.6 0.3 4.1e-05 23.1 0.1 1.9 1 1 1 2 2 2 1 Tellurite resistance protein TehB Methyltransf_PK PF05891.12 EFC37344.1 - 0.00035 20.2 0.0 0.00057 19.5 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_7 PF03492.15 EFC37344.1 - 0.00055 19.2 0.2 0.37 10.0 0.0 2.3 2 0 0 2 2 2 2 SAM dependent carboxyl methyltransferase Methyltransf_32 PF13679.6 EFC37344.1 - 0.0011 18.9 0.4 0.0018 18.3 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFC37344.1 - 0.0046 15.9 0.0 0.0058 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 EFC37344.1 - 0.013 15.3 0.3 0.034 13.9 0.1 1.7 1 1 1 2 2 2 0 Lysine methyltransferase Methyltransf_18 PF12847.7 EFC37344.1 - 0.022 14.7 0.0 0.06 13.3 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain DUF276 PF03434.13 EFC37344.1 - 0.041 13.1 0.0 0.36 10.0 0.0 1.9 2 0 0 2 2 2 0 DUF276 CMAS PF02353.20 EFC37344.1 - 0.048 13.0 0.0 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase TRM13 PF05206.14 EFC37344.1 - 0.08 12.5 0.2 0.2 11.2 0.1 1.8 1 1 1 2 2 2 0 Methyltransferase TRM13 DUF2691 PF10903.8 EFC37344.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2691) PrmA PF06325.13 EFC37344.1 - 0.12 11.7 0.1 0.19 11.1 0.1 1.5 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AdoMet_MTase PF07757.13 EFC37344.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Sel1 PF08238.12 EFC37345.1 - 8.1e-58 191.6 17.9 2.2e-08 34.5 0.1 8.1 8 0 0 8 8 8 8 Sel1 repeat B12-binding_2 PF02607.17 EFC37345.1 - 0.09 13.2 0.0 0.24 11.9 0.0 1.8 1 0 0 1 1 1 0 B12 binding domain NAD_binding_10 PF13460.6 EFC37346.1 - 1.3e-22 80.6 0.0 1.5e-22 80.4 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC37346.1 - 3.4e-08 33.2 0.0 7.4e-08 32.1 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFC37346.1 - 1.6e-07 31.1 0.0 2.3e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 EFC37346.1 - 0.0011 18.4 0.0 0.003 17.0 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EFC37346.1 - 0.0023 17.4 0.1 0.037 13.4 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC37346.1 - 0.023 13.7 1.2 0.04 12.9 0.8 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 EFC37346.1 - 0.029 14.5 0.1 0.062 13.4 0.1 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ATPgrasp_ST PF14397.6 EFC37346.1 - 0.029 13.6 0.1 0.04 13.2 0.1 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF5305 PF17231.2 EFC37347.1 - 0.037 13.4 1.9 0.57 9.6 0.0 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5305) Sp38 PF07354.12 EFC37348.1 - 0.14 11.5 0.2 0.34 10.3 0.2 1.6 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Guanylate_cyc PF00211.20 EFC37349.1 - 5.4e-50 169.6 0.0 9.4e-50 168.8 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC37349.1 - 1.3e-15 57.5 0.0 3.2e-15 56.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC37349.1 - 2.8e-09 37.0 0.0 5.7e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC37349.1 - 0.0087 16.3 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC37349.1 - 0.038 13.4 0.3 0.073 12.5 0.3 1.4 1 0 0 1 1 1 0 Heme NO binding associated Pox_VLTF3 PF04947.14 EFC37349.1 - 0.14 11.9 2.3 0.3 10.8 0.2 2.5 3 0 0 3 3 3 0 Poxvirus Late Transcription Factor VLTF3 like DUF3611 PF12263.8 EFC37349.1 - 0.35 10.8 2.9 0.76 9.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) zf-MYND PF01753.18 EFC37350.1 - 2.5e-09 37.1 18.4 5.8e-09 35.9 18.2 1.8 1 1 0 1 1 1 1 MYND finger DUF4116 PF13475.6 EFC37351.1 - 2.6e-37 126.3 26.1 6.4e-09 35.4 0.0 10.7 5 3 7 12 12 12 9 Domain of unknown function (DUF4116) mTERF PF02536.14 EFC37351.1 - 0.0056 15.6 1.8 0.71 8.7 0.0 3.3 3 1 1 4 4 4 2 mTERF Esterase_phd PF10503.9 EFC37352.1 - 2e-05 24.2 1.3 0.015 14.8 0.0 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase Pneumo_ncap PF03246.13 EFC37352.1 - 0.014 14.2 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Pneumovirus nucleocapsid protein EF-hand_7 PF13499.6 EFC37353.1 - 5.2e-24 84.5 5.6 3e-12 46.8 1.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC37353.1 - 8.2e-22 75.2 12.4 4.8e-06 26.1 1.4 5.0 4 1 1 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 EFC37353.1 - 6.8e-21 72.2 15.4 6.9e-07 28.4 0.6 4.3 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 EFC37353.1 - 4.7e-14 51.2 16.3 8.4e-06 25.1 0.9 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 EFC37353.1 - 6.5e-12 45.1 9.0 0.0014 18.4 0.1 4.2 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC37353.1 - 3.6e-06 27.3 0.1 0.0029 17.9 0.0 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFC37353.1 - 0.012 15.9 0.2 1.9 8.9 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.6 EFC37353.1 - 0.059 13.2 0.7 0.76 9.7 0.1 2.8 3 0 0 3 3 3 0 EF hand BCS1_N PF08740.11 EFC37354.1 - 1.4e-05 25.2 0.2 1.9e-05 24.7 0.2 1.1 1 0 0 1 1 1 1 BCS1 N terminal KRTAP PF11759.8 EFC37354.1 - 0.0093 16.5 62.8 1.8e+04 -24.0 62.8 3.4 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 EFC37354.1 - 0.52 10.4 58.7 1.8e+04 -23.0 58.7 3.4 1 1 0 1 1 1 0 Keratin type II head Actin PF00022.19 EFC37355.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin Thiolase_N PF00108.23 EFC37356.1 - 6.4e-68 228.9 0.0 9.8e-68 228.3 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFC37356.1 - 1.7e-41 140.7 0.1 3e-41 139.9 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFC37356.1 - 1.4e-05 24.8 0.7 6.5e-05 22.6 0.4 2.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain DUF2802 PF10975.8 EFC37356.1 - 0.0036 17.4 0.0 0.82 9.8 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF2802) ACP_syn_III PF08545.10 EFC37356.1 - 0.0051 16.6 0.9 0.71 9.8 0.4 2.7 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ACP_syn_III_C PF08541.10 EFC37356.1 - 0.02 15.1 0.0 0.048 13.8 0.0 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal NAD_binding_2 PF03446.15 EFC37357.1 - 3e-23 82.7 0.0 5.4e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFC37357.1 - 2.7e-10 40.5 0.1 4.2e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 EFC37357.1 - 0.0022 18.1 0.0 0.0048 17.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GST_C_3 PF14497.6 EFC37358.1 - 2.6e-16 59.6 0.2 5.5e-16 58.6 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC37358.1 - 1.2e-07 31.9 0.1 2.5e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC37358.1 - 5.1e-05 23.4 0.1 0.00011 22.3 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC37358.1 - 9.9e-05 22.7 0.1 0.00054 20.3 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC37358.1 - 0.0014 18.6 0.0 0.003 17.5 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFC37358.1 - 0.0037 18.0 0.0 0.0064 17.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain TraE PF05309.11 EFC37358.1 - 0.088 12.2 0.1 0.3 10.4 0.0 1.8 1 1 1 2 2 2 0 TraE protein BTB PF00651.31 EFC37359.1 - 5.3e-18 65.3 0.9 3.2e-16 59.6 0.3 3.3 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EFC37359.1 - 3.1e-12 46.5 3.8 4.3e-10 39.6 0.5 3.4 3 0 0 3 3 3 2 BTB And C-terminal Kelch DUF5349 PF17298.2 EFC37359.1 - 0.45 10.2 16.0 1.6 8.4 16.0 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5349) TetR_C_8 PF14278.6 EFC37359.1 - 0.8 9.8 6.0 37 4.5 0.0 4.5 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region Serglycin PF04360.12 EFC37360.1 - 1.2 9.1 4.9 2.4 8.1 4.9 1.4 1 0 0 1 1 1 0 Serglycin DUF2306 PF10067.9 EFC37361.1 - 5.7e-21 75.3 7.1 5.7e-21 75.3 7.1 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2306) Pkinase PF00069.25 EFC37364.1 - 2e-62 210.9 0.0 2e-62 210.9 0.0 2.5 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37364.1 - 9.6e-37 126.7 0.2 4.9e-36 124.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Myb_DNA-binding PF00249.31 EFC37364.1 - 1.7e-09 37.7 0.2 4.5e-09 36.4 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Kinase-like PF14531.6 EFC37364.1 - 1.4e-05 24.6 0.0 5.6e-05 22.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFC37364.1 - 0.015 15.3 0.0 0.035 14.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family RCC1_2 PF13540.6 EFC37365.1 - 3e-19 68.3 1.4 2.5e-06 27.1 0.0 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37365.1 - 2.3e-09 37.7 0.9 0.0034 18.0 0.1 5.6 6 2 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat Pyrophosphatase PF00719.19 EFC37366.1 - 9.2e-45 152.3 1.9 1.1e-44 152.1 1.9 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase MFS_1 PF07690.16 EFC37367.1 - 7e-32 110.7 33.5 1.1e-23 83.8 15.3 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC37367.1 - 1.2e-09 37.6 4.5 1.2e-09 37.6 4.5 2.7 2 1 1 3 3 3 2 Sugar (and other) transporter MFS_3 PF05977.13 EFC37367.1 - 4.5e-05 22.0 0.8 0.00012 20.7 0.8 1.7 1 0 0 1 1 1 1 Transmembrane secretion effector DUF4094 PF13334.6 EFC37367.1 - 0.025 15.0 0.2 0.091 13.2 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF2371 PF10177.9 EFC37367.1 - 0.07 13.3 0.9 0.67 10.1 0.8 2.7 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) LRR_4 PF12799.7 EFC37368.1 - 8.7e-18 64.1 11.6 4.9e-09 36.3 0.3 4.0 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37368.1 - 1.4e-13 50.4 5.3 1.7e-05 24.5 1.3 3.6 3 1 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 EFC37368.1 - 1.5e-13 50.6 0.1 1.3e-06 28.0 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFC37368.1 - 0.2 12.3 9.2 1.1e+02 4.0 0.0 5.0 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC37368.1 - 0.42 10.8 4.9 29 5.0 0.0 4.1 4 1 0 4 4 4 0 Leucine Rich repeat Pkinase PF00069.25 EFC37369.1 - 1.7e-53 181.7 0.1 5.5e-53 180.0 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37369.1 - 2.6e-50 171.1 0.2 3.5e-49 167.4 0.2 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Chlam_PMP PF02415.17 EFC37369.1 - 5.6e-07 29.7 22.2 0.011 16.2 1.7 6.3 6 0 0 6 6 6 4 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Haspin_kinase PF12330.8 EFC37369.1 - 0.0014 17.7 1.4 0.0018 17.3 0.0 2.0 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFC37369.1 - 0.031 14.2 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EFC37369.1 - 0.098 11.8 0.0 0.46 9.6 0.0 1.9 1 1 1 2 2 2 0 Fructosamine kinase DUF2871 PF11070.8 EFC37370.1 - 4.3e-06 27.0 2.8 4.3e-06 27.0 2.8 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2871) MscS_TM PF12794.7 EFC37370.1 - 0.17 10.7 1.1 0.31 9.9 1.1 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 NHL PF01436.21 EFC37371.1 - 1.3e-37 125.9 0.0 8e-06 25.6 0.0 10.5 10 0 0 10 10 10 8 NHL repeat EGF_2 PF07974.13 EFC37371.1 - 0.023 15.1 9.4 0.056 13.8 9.4 1.7 1 0 0 1 1 1 0 EGF-like domain FlgD_ig PF13860.6 EFC37371.1 - 0.028 14.3 2.1 6.1 6.8 0.1 3.3 2 1 1 3 3 3 0 FlgD Ig-like domain Phytase-like PF13449.6 EFC37371.1 - 0.05 13.5 0.0 36 4.2 0.0 4.3 3 2 0 4 4 4 0 Esterase-like activity of phytase DUF5074 PF16819.5 EFC37371.1 - 0.11 12.6 0.2 6.4 6.9 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5074) Arg_repressor_C PF02863.18 EFC37371.1 - 1.8 8.5 5.5 54 3.7 0.1 4.3 5 0 0 5 5 5 0 Arginine repressor, C-terminal domain hEGF PF12661.7 EFC37371.1 - 3.6 8.4 7.0 10 6.9 7.0 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF WD40 PF00400.32 EFC37372.1 - 1.3e-25 89.1 0.6 9.9e-06 26.2 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC37372.1 - 1.8e-14 53.8 0.0 0.00019 21.7 0.0 4.6 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC37372.1 - 0.0013 17.8 0.8 0.053 12.5 0.0 3.1 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 EFC37372.1 - 0.019 14.9 0.0 0.081 12.9 0.0 2.1 2 0 0 2 2 2 0 PQQ enzyme repeat PQQ_2 PF13360.6 EFC37372.1 - 0.053 13.1 0.1 10 5.6 0.0 2.5 2 1 0 2 2 2 0 PQQ-like domain Coatomer_WDAD PF04053.14 EFC37372.1 - 0.067 12.2 0.0 0.14 11.1 0.0 1.5 2 0 0 2 2 2 0 Coatomer WD associated region RAB3GAP2_N PF14655.6 EFC37372.1 - 0.07 12.4 0.0 0.35 10.1 0.0 2.1 2 1 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus RCC1 PF00415.18 EFC37373.1 - 1e-26 93.3 0.2 6.6e-06 26.7 0.0 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37373.1 - 4.8e-18 64.5 11.7 0.0029 17.4 0.0 7.2 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat AAA_5 PF07728.14 EFC37374.1 - 6.9e-06 26.1 0.0 1.7e-05 24.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC37374.1 - 0.00037 20.8 0.0 0.00068 19.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC37374.1 - 0.0016 18.6 0.0 0.0034 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFC37374.1 - 0.047 13.2 0.0 0.083 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 EFC37374.1 - 0.057 12.6 0.4 0.12 11.5 0.4 1.6 1 1 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 EFC37374.1 - 0.078 12.7 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC37374.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 EFC37374.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain T2SSJ PF11612.8 EFC37375.1 - 0.097 12.9 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein J CD34_antigen PF06365.12 EFC37376.1 - 0.076 12.6 0.0 0.65 9.6 0.0 2.0 2 0 0 2 2 2 0 CD34/Podocalyxin family Methyltransf_31 PF13847.6 EFC37377.1 - 4.5e-22 78.5 0.0 6.6e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC37377.1 - 1.5e-12 48.0 0.0 3.5e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC37377.1 - 1.2e-11 45.1 0.0 3.3e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC37377.1 - 1.7e-09 38.3 0.0 3.5e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC37377.1 - 4.5e-09 36.0 0.0 1.8e-07 30.8 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC37377.1 - 2.7e-08 33.8 0.0 3.8e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 EFC37377.1 - 1.7e-05 24.4 0.1 0.00087 18.9 0.1 2.3 1 1 1 2 2 2 1 Histone methylation protein DOT1 PCMT PF01135.19 EFC37377.1 - 0.00022 21.0 0.1 0.00037 20.3 0.1 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 EFC37377.1 - 0.017 15.1 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.26 EFC37377.1 - 0.044 13.8 0.0 0.14 12.1 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase HMA PF00403.26 EFC37377.1 - 0.14 12.6 0.1 0.45 11.0 0.0 1.8 2 0 0 2 2 1 0 Heavy-metal-associated domain DUF5502 PF17606.2 EFC37377.1 - 0.32 11.7 1.8 11 6.8 0.2 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5502) Ras PF00071.22 EFC37378.1 - 3.1e-57 192.7 2.2 3.7e-57 192.4 2.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37378.1 - 1.5e-34 118.7 1.2 2.5e-34 118.0 1.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC37378.1 - 1.8e-16 60.1 1.2 2.3e-16 59.8 1.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC37378.1 - 1.5e-08 34.3 0.3 1.8e-08 34.1 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC37378.1 - 0.0001 21.9 1.4 0.00018 21.1 1.4 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC37378.1 - 0.00021 21.3 0.2 0.00039 20.5 0.2 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC37378.1 - 0.00036 20.5 1.1 0.58 10.0 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 EFC37378.1 - 0.0017 17.8 0.2 0.0022 17.5 0.2 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ArabFuran-catal PF09206.11 EFC37378.1 - 0.003 16.9 0.3 0.0054 16.1 0.2 1.4 1 1 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic PduV-EutP PF10662.9 EFC37378.1 - 0.011 15.5 0.5 0.44 10.3 0.1 2.8 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EFC37378.1 - 0.023 15.1 0.5 0.34 11.3 0.4 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC37378.1 - 0.035 14.5 0.0 0.047 14.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 EFC37378.1 - 0.058 12.6 0.1 0.13 11.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFC37378.1 - 0.071 12.6 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 EFC37378.1 - 0.14 12.1 0.0 0.29 11.1 0.0 1.5 2 0 0 2 2 2 0 NACHT domain NAP PF00956.18 EFC37379.1 - 8.7e-72 241.5 17.4 1.5e-71 240.8 17.4 1.4 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) A_deamin PF02137.18 EFC37379.1 - 1.1 8.6 4.1 0.17 11.3 0.3 1.5 2 0 0 2 2 2 0 Adenosine-deaminase (editase) domain Miga PF10265.9 EFC37380.1 - 0.033 13.2 7.3 0.038 13.0 7.3 1.1 1 0 0 1 1 1 0 Mitoguardin SMYLE_N PF18615.1 EFC37380.1 - 4.1 6.9 9.1 5.2 6.5 9.1 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Macoilin PF09726.9 EFC37380.1 - 6.2 5.3 13.7 7.6 5.0 13.7 1.2 1 0 0 1 1 1 0 Macoilin family Peptidase_M54 PF07998.11 EFC37381.1 - 1.7e-07 31.4 1.9 4.6e-07 30.0 1.3 1.9 2 0 0 2 2 2 1 Peptidase family M54 Sharpin_PH PF16764.5 EFC37381.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Sharpin PH domain Chromate_transp PF02417.15 EFC37382.1 - 2.9e-45 154.2 15.6 3e-41 141.2 10.8 2.5 3 0 0 3 3 3 2 Chromate transporter DUF5305 PF17231.2 EFC37382.1 - 0.074 12.4 0.3 5.2 6.4 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5305) Vfa1 PF08432.10 EFC37385.1 - 0.2 12.0 9.7 0.48 10.7 9.7 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Roughex PF06020.11 EFC37385.1 - 0.41 9.7 4.1 1.7 7.6 2.8 2.3 2 0 0 2 2 2 0 Drosophila roughex protein CDC45 PF02724.14 EFC37385.1 - 0.57 8.4 6.3 0.86 7.8 6.3 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 EFC37385.1 - 0.69 9.6 4.3 1.5 8.5 4.3 1.5 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 EFC37385.1 - 0.75 7.8 10.2 1.2 7.2 10.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFC37385.1 - 3.6 6.8 14.4 5.5 6.2 14.4 1.2 1 0 0 1 1 1 0 NOA36 protein SE PF08491.10 EFC37386.1 - 0.0033 16.5 0.0 0.011 14.8 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EFC37386.1 - 0.035 13.3 0.0 0.082 12.1 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFC37386.1 - 0.18 10.6 0.0 8.8 5.1 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Pkinase PF00069.25 EFC37388.1 - 2.5e-13 50.0 0.1 4.9e-12 45.8 0.1 2.4 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFC37388.1 - 0.00097 19.1 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ras PF00071.22 EFC37389.1 - 0.0031 17.1 0.0 0.0065 16.1 0.0 1.6 1 0 0 1 1 1 1 Ras family Crl PF07417.12 EFC37389.1 - 0.073 13.1 0.3 8 6.6 0.1 2.3 2 0 0 2 2 2 0 Sigma factor-binding transcriptional regulator Crl HALZ PF02183.18 EFC37390.1 - 0.01 16.1 2.1 0.025 14.8 2.1 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper DASH_Dad3 PF08656.10 EFC37390.1 - 0.021 14.9 0.4 0.054 13.6 0.4 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad3 F-box PF00646.33 EFC37390.1 - 0.024 14.5 0.0 0.075 12.9 0.0 1.8 1 0 0 1 1 1 0 F-box domain RCC1 PF00415.18 EFC37391.1 - 1.7e-39 134.2 6.3 2.5e-07 31.2 0.1 7.7 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37391.1 - 7.4e-36 121.2 6.5 1.6e-07 30.9 0.1 6.7 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC37391.1 - 2.1e-12 47.2 1.5 4.2e-09 36.6 0.4 2.8 2 0 0 2 2 2 2 BTB/POZ domain FA_hydroxylase PF04116.13 EFC37392.1 - 4.9e-28 98.1 16.6 4.9e-28 98.1 16.6 1.9 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF373 PF04123.13 EFC37392.1 - 0.24 10.8 0.1 0.39 10.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) F-box-like PF12937.7 EFC37394.1 - 4.4e-07 29.7 0.2 1.1e-06 28.4 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37394.1 - 1e-06 28.4 0.2 1e-06 28.4 0.2 2.4 3 0 0 3 3 3 1 F-box domain API5 PF05918.11 EFC37395.1 - 2.3e-81 274.2 17.1 2.9e-81 273.9 17.1 1.1 1 0 0 1 1 1 1 Apoptosis inhibitory protein 5 (API5) Cnd1 PF12717.7 EFC37395.1 - 0.0046 17.0 2.4 0.0046 17.0 2.4 2.8 2 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EFC37395.1 - 0.072 13.3 0.8 0.26 11.5 0.1 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Ribosomal_S15 PF00312.22 EFC37395.1 - 0.27 11.5 3.8 0.24 11.6 1.1 2.3 2 0 0 2 2 2 0 Ribosomal protein S15 Cofilin_ADF PF00241.20 EFC37396.1 - 7.4e-10 38.7 0.1 2.5e-09 37.0 0.1 1.9 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PRR18 PF15671.5 EFC37396.1 - 0.22 11.4 9.7 0.35 10.7 9.7 1.3 1 0 0 1 1 1 0 Proline-rich protein family 18 FAM195 PF14799.6 EFC37396.1 - 0.5 10.7 4.9 1.5 9.2 5.0 1.9 1 1 0 1 1 1 0 FAM195 family V_ATPase_I PF01496.19 EFC37396.1 - 3.3 5.5 10.0 4.7 5.0 10.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 EFC37396.1 - 6.8 6.5 19.3 1.4 8.7 6.7 3.5 2 1 1 3 3 3 0 Septum formation initiator RhoGEF PF00621.20 EFC37397.1 - 1.5e-41 142.6 1.7 5.7e-41 140.7 1.7 2.1 1 0 0 1 1 1 1 RhoGEF domain Tom22 PF04281.13 EFC37397.1 - 9.9 6.0 8.4 5.2 6.9 0.0 3.4 3 0 0 3 3 3 0 Mitochondrial import receptor subunit Tom22 DUF1664 PF07889.12 EFC37398.1 - 0.0023 18.0 1.1 0.0023 18.0 1.1 5.1 2 1 4 6 6 6 3 Protein of unknown function (DUF1664) DUF812 PF05667.11 EFC37398.1 - 0.0035 16.3 7.0 0.0035 16.3 7.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF812) SlyX PF04102.12 EFC37398.1 - 0.027 15.1 2.1 0.027 15.1 2.1 5.4 3 2 1 5 5 5 0 SlyX RraB PF06877.11 EFC37398.1 - 0.04 14.7 0.6 0.04 14.7 0.6 2.7 3 0 0 3 3 3 0 Regulator of ribonuclease activity B SF-assemblin PF06705.11 EFC37398.1 - 0.22 10.8 46.9 0.016 14.6 17.5 3.0 1 1 2 3 3 3 0 SF-assemblin/beta giardin DUF883 PF05957.13 EFC37398.1 - 0.35 11.5 10.0 0.76 10.4 0.2 4.2 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF883) Spc7 PF08317.11 EFC37398.1 - 2.5 6.9 45.7 0.31 9.9 1.1 3.6 2 1 1 3 3 3 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 EFC37398.1 - 3.1 7.8 44.3 0.56 10.2 10.4 4.7 1 1 4 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 EFC37398.1 - 5.2 7.6 31.4 0.87 10.1 0.8 4.9 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Filament PF00038.21 EFC37398.1 - 5.3 6.5 40.8 3.9 7.0 33.9 3.7 1 1 1 2 2 2 0 Intermediate filament protein Y_Y_Y PF07495.13 EFC37399.1 - 0.00098 19.0 0.3 0.0095 15.9 0.0 2.5 2 0 0 2 2 2 1 Y_Y_Y domain REJ PF02010.15 EFC37399.1 - 0.0046 15.8 1.1 0.1 11.4 0.7 2.8 2 1 1 3 3 3 1 REJ domain Big_3_5 PF16640.5 EFC37399.1 - 0.039 14.1 3.1 0.5 10.6 0.1 2.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) He_PIG PF05345.12 EFC37399.1 - 0.78 10.0 3.2 18 5.6 0.5 3.2 2 1 1 3 3 3 0 Putative Ig domain Hydrolase_4 PF12146.8 EFC37400.1 - 5.5e-08 32.4 0.0 7.2e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 EFC37400.1 - 4.5e-07 29.7 0.1 6.3e-07 29.2 0.1 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 EFC37400.1 - 3.3e-05 24.6 0.0 4e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC37400.1 - 0.0033 17.1 0.1 0.0065 16.2 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 EFC37400.1 - 0.083 12.8 0.2 0.13 12.1 0.2 1.4 1 1 0 1 1 1 0 Lipase (class 3) ubiquitin PF00240.23 EFC37403.1 - 1.7e-62 207.1 6.3 8.4e-31 105.5 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC37403.1 - 8.1e-30 102.5 8.3 1.4e-14 53.7 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC37403.1 - 1e-08 34.9 0.4 0.0019 18.1 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 EFC37403.1 - 1.3e-08 35.2 3.8 0.0024 18.3 0.5 3.0 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC37403.1 - 1.8e-08 34.4 0.4 0.0013 18.8 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC37403.1 - 3.3e-07 30.6 2.3 0.013 15.8 0.2 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC37403.1 - 7.9e-07 29.6 0.1 0.0094 16.5 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC37403.1 - 6.9e-05 22.8 7.5 2.6 8.2 0.2 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain bPH_3 PF14470.6 EFC37403.1 - 0.02 15.3 1.3 0.84 10.0 0.2 2.7 2 1 0 3 3 3 0 Bacterial PH domain DUF3861 PF12977.7 EFC37403.1 - 0.048 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) Coagulin PF02035.15 EFC37403.1 - 0.052 13.4 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin Raf1_HTH PF18579.1 EFC37403.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC37403.1 - 0.13 12.4 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC37403.1 - 0.22 11.7 1.6 2 8.6 0.3 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain ABC2_membrane PF01061.24 EFC37404.1 - 1.8e-46 158.2 21.8 1.8e-46 158.2 21.8 1.5 2 0 0 2 2 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC37404.1 - 1.1e-28 100.4 0.1 1.1e-28 100.4 0.1 2.6 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 EFC37404.1 - 1.3e-06 28.4 0.0 0.0088 15.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFC37404.1 - 3e-06 26.6 25.6 3e-06 26.6 25.6 3.1 2 1 0 2 2 2 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFC37404.1 - 1.9e-05 24.6 0.5 0.00017 21.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EFC37404.1 - 0.0015 19.0 0.0 0.0036 17.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFC37404.1 - 0.0074 16.7 0.1 0.11 13.0 0.1 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 EFC37404.1 - 0.0083 15.9 0.0 0.082 12.6 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 EFC37404.1 - 0.014 15.6 0.1 0.083 13.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_35 PF14516.6 EFC37404.1 - 0.034 13.0 0.0 0.063 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain PDR_CDR PF06422.12 EFC37404.1 - 0.041 13.8 0.3 0.13 12.2 0.3 1.9 1 0 0 1 1 1 0 CDR ABC transporter RNA_helicase PF00910.22 EFC37404.1 - 0.057 13.8 0.6 0.22 11.9 0.0 2.2 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 EFC37404.1 - 0.064 13.3 0.2 0.2 11.8 0.2 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase KAP_NTPase PF07693.14 EFC37404.1 - 0.099 11.9 0.0 0.099 11.9 0.0 1.8 2 0 0 2 2 1 0 KAP family P-loop domain AAA_28 PF13521.6 EFC37404.1 - 0.1 12.8 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC37404.1 - 0.16 12.5 0.6 0.69 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 EFC37405.1 - 4.3e-30 105.0 4.4 9.8e-30 103.8 4.4 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37405.1 - 7.2e-30 104.1 0.9 5.9e-29 101.1 0.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Hydrolase_4 PF12146.8 EFC37406.1 - 6.2e-06 25.7 0.0 1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S28 PF05577.12 EFC37406.1 - 0.0033 16.3 0.0 0.0073 15.1 0.0 1.5 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Tubulin PF00091.25 EFC37407.1 - 1.9e-55 188.1 0.1 3.5e-55 187.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC37407.1 - 1.3e-26 93.2 0.3 2e-26 92.6 0.3 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC37407.1 - 0.002 17.9 0.0 0.0039 16.9 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain TF_AP-2 PF03299.14 EFC37408.1 - 0.01 15.8 0.5 0.019 15.0 0.5 1.5 1 0 0 1 1 1 0 Transcription factor AP-2 RGS PF00615.19 EFC37410.1 - 1.4e-06 28.6 0.7 3.3e-06 27.3 0.7 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 EFC37411.1 - 2.2e-11 44.1 0.3 2.9e-11 43.7 0.3 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain DAO PF01266.24 EFC37412.1 - 7e-35 121.2 0.0 8.8e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Ribosomal_L44 PF00935.19 EFC37412.1 - 4.5e-17 62.3 6.8 1e-16 61.1 6.8 1.6 1 0 0 1 1 1 1 Ribosomal protein L44 Rieske PF00355.26 EFC37412.1 - 2.1e-14 53.2 1.7 4.1e-14 52.3 0.5 2.1 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Pyr_redox_2 PF07992.14 EFC37412.1 - 2e-06 27.2 0.2 0.00031 20.1 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC37412.1 - 6.7e-06 25.6 0.4 0.0012 18.1 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC37412.1 - 1.2e-05 24.2 0.2 0.041 12.6 0.3 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 EFC37412.1 - 2e-05 23.9 1.0 5.3e-05 22.5 0.3 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EFC37412.1 - 0.0002 21.9 0.3 0.0086 16.6 0.4 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFC37412.1 - 0.0013 18.2 0.1 0.002 17.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC37412.1 - 0.0014 17.9 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFC37412.1 - 0.0016 18.6 0.4 0.005 17.0 0.4 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 EFC37412.1 - 0.01 16.3 0.1 0.021 15.3 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Thi4 PF01946.17 EFC37412.1 - 0.011 15.1 0.1 0.03 13.6 0.1 1.7 1 0 0 1 1 1 0 Thi4 family Amino_oxidase PF01593.24 EFC37412.1 - 0.014 14.7 0.1 0.21 10.8 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase hSac2 PF12456.8 EFC37413.1 - 2.1e-05 24.2 0.0 5.6e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Inositol phosphatase DJ-1_PfpI PF01965.24 EFC37414.1 - 4.7e-38 130.6 0.0 5.6e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 EFC37414.1 - 0.0019 18.0 0.0 0.0026 17.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ThiJ_like PF17124.5 EFC37414.1 - 0.083 12.6 0.0 0.27 10.9 0.0 1.9 1 1 0 1 1 1 0 ThiJ/PfpI family-like LCAT PF02450.15 EFC37415.1 - 1.6e-33 116.5 3.1 1.3e-25 90.4 0.4 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EFC37415.1 - 0.0012 18.4 0.0 0.0025 17.4 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFC37415.1 - 0.034 13.9 0.2 0.63 9.7 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein Abhydrolase_1 PF00561.20 EFC37415.1 - 0.052 13.2 0.1 0.099 12.3 0.1 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC37415.1 - 0.097 11.9 0.0 0.18 11.0 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LRR_6 PF13516.6 EFC37416.1 - 3.1e-46 151.5 23.6 0.0011 18.8 0.0 12.4 12 0 0 12 12 12 11 Leucine Rich repeat LRR_8 PF13855.6 EFC37416.1 - 1.5e-30 104.8 30.0 1.9e-09 37.1 0.4 6.5 2 1 6 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EFC37416.1 - 1.4e-21 76.1 27.9 4.5e-06 26.9 0.0 8.5 4 2 3 9 9 9 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37416.1 - 8e-16 56.2 14.3 0.85 10.4 0.3 11.3 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC37416.1 - 0.00012 21.6 7.1 0.0032 17.0 0.9 3.7 1 1 3 4 4 4 1 Leucine-rich repeat DUF4347 PF14252.6 EFC37416.1 - 0.00019 21.3 1.1 4.5 7.1 0.1 5.2 3 2 3 6 6 6 1 Domain of unknown function (DUF4347) PapC_C PF13953.6 EFC37416.1 - 0.041 13.7 0.4 9.3 6.1 0.0 3.0 3 0 0 3 3 3 0 PapC C-terminal domain DUF836 PF05768.14 EFC37416.1 - 0.056 13.9 0.8 0.056 13.9 0.8 2.9 3 1 0 3 3 3 0 Glutaredoxin-like domain (DUF836) RNA_pol_I_TF PF04090.12 EFC37416.1 - 0.36 10.3 4.4 22 4.5 0.2 3.7 3 2 1 4 4 4 0 RNA polymerase I specific initiation factor Ribosomal_L12_N PF16320.5 EFC37416.1 - 2 8.2 4.8 4.8 7.0 0.6 3.6 3 0 0 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain NHL PF01436.21 EFC37417.1 - 0.043 13.9 3.0 3.9 7.7 0.0 3.4 4 0 0 4 4 4 0 NHL repeat BCDHK_Adom3 PF10436.9 EFC37418.1 - 1.4e-46 158.3 0.1 2e-46 157.8 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 EFC37418.1 - 2.6e-12 47.3 0.0 5.5e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFC37418.1 - 0.0019 18.0 0.0 0.0039 17.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BLM10_mid PF16507.5 EFC37419.1 - 1.9e-67 228.1 29.5 3.3e-36 125.0 4.9 3.7 4 0 0 4 4 4 2 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 EFC37419.1 - 4.1e-22 77.9 2.1 2.6e-21 75.3 0.4 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) HEAT PF02985.22 EFC37419.1 - 0.00097 19.2 0.1 1.9 9.0 0.0 5.1 4 0 0 4 4 4 1 HEAT repeat RGS PF00615.19 EFC37420.1 - 0.0002 21.6 2.8 0.0002 21.6 2.8 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain LRR_6 PF13516.6 EFC37421.1 - 0.12 12.5 12.6 0.52 10.5 0.0 5.4 5 0 0 5 5 5 0 Leucine Rich repeat LRR_8 PF13855.6 EFC37421.1 - 0.53 10.1 22.1 0.98 9.2 0.3 5.1 4 2 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.7 EFC37421.1 - 0.55 10.7 34.3 1.5 9.4 0.6 6.4 2 2 4 6 6 6 0 Leucine Rich repeats (2 copies) Gelsolin PF00626.22 EFC37422.1 - 5e-44 148.1 0.3 1e-15 57.4 0.0 3.4 3 0 0 3 3 3 3 Gelsolin repeat C2 PF00168.30 EFC37422.1 - 1.7e-16 60.3 0.0 4.3e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain VPS13_C PF16909.5 EFC37423.1 - 2.4e-44 151.2 1.3 2.4e-44 151.2 1.3 4.0 4 0 0 4 4 4 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EFC37423.1 - 5.9e-40 137.5 21.6 6.8e-40 137.3 3.1 5.7 4 2 1 6 6 6 2 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 EFC37423.1 - 1.6e-31 108.8 0.2 1.6e-31 108.8 0.2 4.0 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EFC37423.1 - 1.4e-08 34.9 0.1 9e-08 32.4 0.0 2.3 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Goodbye PF17109.5 EFC37423.1 - 0.1 13.1 4.6 0.17 12.3 0.0 3.6 3 0 0 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF4397 PF14344.6 EFC37423.1 - 0.14 13.0 2.9 2.7 8.8 0.3 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4397) NTP_transf_2 PF01909.23 EFC37426.1 - 7.1e-06 26.2 0.5 2.4e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFC37426.1 - 2.3e-05 24.4 0.2 9.3e-05 22.4 0.2 2.0 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase RlaP PF10127.9 EFC37426.1 - 0.00012 21.8 2.7 0.019 14.5 0.0 3.0 3 0 0 3 3 3 2 RNA repair pathway DNA polymerase beta family RGS PF00615.19 EFC37426.1 - 0.79 10.0 4.4 1.7 8.9 0.2 2.8 2 0 0 2 2 2 0 Regulator of G protein signaling domain adh_short PF00106.25 EFC37427.1 - 1.3e-22 80.3 0.0 7.6e-22 77.7 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC37427.1 - 9.1e-13 48.3 0.0 1.3e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC37427.1 - 1.9e-07 31.2 0.0 2.9e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFC37427.1 - 0.00067 19.2 0.2 0.0016 17.9 0.2 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Asp PF00026.23 EFC37428.1 - 8.8e-101 337.5 8.9 1.1e-100 337.1 8.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFC37428.1 - 7.6e-13 49.1 4.9 1.1e-08 35.6 0.2 2.6 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EFC37428.1 - 8e-05 22.5 0.1 0.00055 19.8 0.0 2.5 3 1 0 3 3 3 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 EFC37428.1 - 0.009 16.6 0.0 1.3 9.7 0.0 2.8 2 1 0 2 2 2 1 Aspartyl protease CHASE4 PF05228.13 EFC37429.1 - 2.1e-07 31.2 0.0 4.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 CHASE4 domain PAS_9 PF13426.7 EFC37429.1 - 0.0026 18.0 0.2 0.016 15.5 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.7 EFC37429.1 - 0.0028 17.7 0.0 0.017 15.1 0.0 2.2 2 0 0 2 2 2 1 PAS domain DUF4006 PF13179.6 EFC37429.1 - 1.4 8.9 8.1 7.8 6.5 8.1 2.4 1 1 0 1 1 1 0 Family of unknown function (DUF4006) FMN_bind_2 PF04299.12 EFC37430.1 - 3.4e-44 150.5 0.1 4.4e-44 150.2 0.1 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain DUF1152 PF06626.12 EFC37432.1 - 1.2e-17 64.0 0.0 6.7e-17 61.6 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1152) Jas PF16135.5 EFC37433.1 - 0.01 16.0 1.9 0.012 15.8 0.7 1.8 2 0 0 2 2 2 0 TPL-binding domain in jasmonate signalling Med4 PF10018.9 EFC37433.1 - 0.96 9.1 9.0 1.8 8.2 9.0 1.6 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 NAGPA PF09992.9 EFC37435.1 - 2.3e-05 24.6 0.1 6.7e-05 23.1 0.1 1.6 2 0 0 2 2 2 1 Phosphodiester glycosidase Peripla_BP_6 PF13458.6 EFC37436.1 - 1.3e-37 130.3 0.0 2.4e-10 40.6 0.0 5.0 4 1 0 4 4 4 4 Periplasmic binding protein Guanylate_cyc PF00211.20 EFC37436.1 - 5.2e-23 81.6 0.1 2.5e-22 79.4 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 EFC37436.1 - 3.1e-10 39.7 10.0 0.0031 16.7 1.9 3.8 3 1 0 3 3 3 3 Receptor family ligand binding region Glyco_hydro_cc PF11790.8 EFC37437.1 - 2.7e-54 184.3 3.3 3.2e-54 184.0 3.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_39 PF01229.17 EFC37437.1 - 0.0036 16.0 0.0 0.0056 15.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Pkinase PF00069.25 EFC37438.1 - 4.5e-25 88.5 5.5 4.5e-25 88.5 5.5 3.1 3 1 0 3 3 3 1 Protein kinase domain CNH PF00780.22 EFC37438.1 - 2.2e-16 60.3 1.1 6e-16 58.9 0.2 2.1 2 0 0 2 2 2 1 CNH domain DUF4116 PF13475.6 EFC37438.1 - 7.2e-13 48.0 1.5 7.2e-13 48.0 1.5 2.4 2 0 0 2 2 1 1 Domain of unknown function (DUF4116) Vps39_1 PF10366.9 EFC37438.1 - 5.9e-08 32.9 1.8 5.9e-08 32.9 1.8 2.5 3 0 0 3 3 2 1 Vacuolar sorting protein 39 domain 1 Pkinase_Tyr PF07714.17 EFC37438.1 - 3.3e-07 29.8 4.0 3.5e-07 29.8 0.7 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase DivIC PF04977.15 EFC37438.1 - 0.0021 17.8 1.9 0.073 12.8 2.3 3.2 2 0 0 2 2 2 1 Septum formation initiator HALZ PF02183.18 EFC37438.1 - 0.024 14.8 5.3 0.096 12.9 5.3 2.1 1 0 0 1 1 1 0 Homeobox associated leucine zipper RIO1 PF01163.22 EFC37438.1 - 0.027 14.1 0.5 0.027 14.1 0.5 2.5 3 0 0 3 3 3 0 RIO1 family Kdo PF06293.14 EFC37438.1 - 0.072 12.4 0.2 0.16 11.3 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TolA_bind_tri PF16331.5 EFC37438.1 - 0.98 9.5 4.9 1.7 8.8 3.9 2.0 1 1 0 1 1 1 0 TolA binding protein trimerisation bZIP_1 PF00170.21 EFC37438.1 - 1.3 9.2 9.7 0.62 10.2 5.7 2.7 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.12 EFC37438.1 - 4.5 7.8 13.5 0.27 11.7 5.9 3.0 3 0 0 3 3 3 0 Cell division protein ZapB Cnn_1N PF07989.11 EFC37438.1 - 4.6 7.5 13.6 6 7.1 9.3 3.4 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Csm1_N PF18504.1 EFC37438.1 - 4.8 7.6 9.6 0.71 10.3 4.1 2.6 3 0 0 3 3 2 0 Csm1 N-terminal domain EGF_2 PF07974.13 EFC37439.1 - 1.4e-30 105.3 143.0 0.00023 21.5 12.8 8.8 5 2 3 8 8 8 8 EGF-like domain hEGF PF12661.7 EFC37439.1 - 1.8e-10 41.1 119.9 0.086 13.5 5.2 9.4 8 0 0 8 8 8 8 Human growth factor-like EGF EGF PF00008.27 EFC37439.1 - 3.9e-05 23.8 129.5 0.022 15.1 9.2 8.8 8 0 0 8 8 8 6 EGF-like domain Response_reg PF00072.24 EFC37440.1 - 8.2e-21 74.3 0.2 8.4e-20 71.0 0.0 2.4 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 EFC37440.1 - 2.4e-17 63.4 0.3 1.2e-16 61.2 0.3 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NDC10_II PF16787.5 EFC37443.1 - 0.013 14.6 5.4 0.72 8.8 0.2 2.3 2 0 0 2 2 2 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 PI3Ka PF00613.20 EFC37444.1 - 1.6e-12 47.2 1.4 4e-12 45.9 1.4 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) LRR_6 PF13516.6 EFC37444.1 - 0.44 10.7 4.5 41 4.6 3.2 3.8 2 0 0 2 2 2 0 Leucine Rich repeat Pkinase PF00069.25 EFC37445.1 - 1.1e-21 77.4 0.0 2.2e-21 76.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37445.1 - 1.1e-12 47.8 0.0 4.3e-11 42.6 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC37445.1 - 6.7e-08 31.7 0.0 1.2e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Oxidored_q2 PF00420.24 EFC37446.1 - 0.012 15.3 3.5 0.12 12.0 0.0 2.8 3 1 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L LapA_dom PF06305.11 EFC37446.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.0 3 1 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF4231 PF14015.6 EFC37446.1 - 0.14 12.6 4.1 3.6 8.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) Pex24p PF06398.11 EFC37446.1 - 3 6.7 12.4 0.035 13.1 3.1 2.3 3 0 0 3 3 3 0 Integral peroxisomal membrane peroxin DUF2207 PF09972.9 EFC37446.1 - 5.8 5.6 7.4 12 4.5 0.0 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF1682 PF07946.14 EFC37447.1 - 0.001 18.4 0.4 1.1 8.4 0.1 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF1682) ODV-E18 PF10717.9 EFC37447.1 - 3 7.8 7.9 1.7 8.6 2.2 2.6 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 XRN_N PF03159.18 EFC37448.1 - 7.5e-32 110.7 1.2 3.4e-25 88.9 0.0 2.6 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus dsrm PF00035.26 EFC37448.1 - 0.0062 17.2 0.6 0.052 14.3 0.1 2.6 2 0 0 2 2 2 1 Double-stranded RNA binding motif ThiF PF00899.21 EFC37449.1 - 6.4e-60 202.5 0.0 9.6e-60 202.0 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 EFC37449.1 - 6.2e-17 61.5 0.2 1.2e-16 60.6 0.2 1.5 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 EFC37449.1 - 0.003 17.6 0.5 0.0091 16.1 0.0 2.1 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase CDtoxinA PF03498.14 EFC37449.1 - 0.1 12.2 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain Polbeta PF18765.1 EFC37450.1 - 4.3e-06 26.7 3.9 4.6e-06 26.6 0.6 2.8 3 0 0 3 3 3 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 EFC37450.1 - 0.00058 20.1 0.2 0.0021 18.3 0.2 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase domain YqzH PF14164.6 EFC37450.1 - 0.19 11.8 2.4 5.9 7.1 0.1 3.6 3 0 0 3 3 3 0 YqzH-like protein DUF4710 PF15828.5 EFC37450.1 - 0.29 11.3 2.8 7.9 6.7 1.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Integrin_b_cyt PF08725.11 EFC37450.1 - 0.53 10.0 6.3 0.17 11.6 0.7 3.1 3 0 0 3 3 3 0 Integrin beta cytoplasmic domain Clathrin PF00637.20 EFC37451.1 - 3.5e-12 46.4 3.5 3.5e-12 46.4 3.5 3.6 3 1 0 3 3 3 1 Region in Clathrin and VPS VPS11_C PF12451.8 EFC37451.1 - 8.1e-09 35.6 0.3 8.1e-09 35.6 0.3 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 EFC37451.1 - 4.5e-06 26.6 7.2 1.5e-05 25.0 7.2 2.0 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EFC37451.1 - 0.019 14.8 6.1 0.046 13.6 6.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BBS2_N PF14781.6 EFC37451.1 - 0.076 12.9 0.0 0.41 10.6 0.0 2.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal zf-RING_2 PF13639.6 EFC37451.1 - 0.1 13.0 6.4 0.26 11.7 6.4 1.8 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 EFC37451.1 - 0.25 11.4 4.1 0.66 10.1 4.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFC37451.1 - 0.94 9.8 4.3 3.6 8.0 4.3 2.0 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFC37451.1 - 1.8 8.6 6.4 5.9 6.9 6.4 2.0 1 0 0 1 1 1 0 zinc-RING finger domain Astro_capsid_p PF12226.8 EFC37451.1 - 4.9 6.2 7.7 13 4.8 7.7 1.6 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Guanylate_cyc PF00211.20 EFC37452.1 - 1.3e-17 64.0 0.4 2.8e-17 62.9 0.2 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC37452.1 - 0.017 14.9 0.5 0.017 14.9 0.5 1.9 2 0 0 2 2 2 0 Cache domain Rogdi_lz PF10259.9 EFC37453.1 - 1.1e-13 51.2 8.5 1.8e-13 50.6 5.3 2.1 1 1 1 2 2 2 1 Rogdi leucine zipper containing protein DCX PF03607.17 EFC37453.1 - 0.093 12.8 0.0 9.4 6.4 0.0 2.6 2 0 0 2 2 2 0 Doublecortin NHL PF01436.21 EFC37454.1 - 7.7e-05 22.5 0.6 0.3 11.2 0.0 4.8 5 0 0 5 5 5 2 NHL repeat SGL PF08450.12 EFC37454.1 - 0.043 13.4 0.1 9 5.8 0.0 3.0 2 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region DUF4116 PF13475.6 EFC37455.1 - 5e-78 256.7 17.2 2.3e-20 72.0 0.0 5.9 3 1 3 6 6 6 6 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 EFC37455.1 - 0.00014 22.0 0.0 4.4 7.4 0.0 4.4 1 1 4 5 5 5 1 Rsbr N terminal DUF4853 PF16145.5 EFC37455.1 - 0.0022 18.1 0.1 0.077 13.1 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4853) GLTP PF08718.11 EFC37455.1 - 0.018 15.3 1.6 1.4 9.2 0.2 3.1 1 1 2 3 3 3 0 Glycolipid transfer protein (GLTP) DUF3288 PF11691.8 EFC37455.1 - 0.091 12.8 0.2 0.33 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3288) RII_binding_1 PF10522.9 EFC37455.1 - 1.6 9.1 3.6 2.9 8.4 0.1 3.1 3 0 0 3 3 3 0 RII binding domain p450 PF00067.22 EFC37456.1 - 3.2e-54 184.4 2.4 6.2e-54 183.5 2.4 1.4 1 1 0 1 1 1 1 Cytochrome P450 GST_N PF02798.20 EFC37458.1 - 5.2e-19 68.4 0.0 8.2e-19 67.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC37458.1 - 2.4e-18 66.3 0.0 3.9e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC37458.1 - 6.5e-16 58.4 0.0 9.7e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC37458.1 - 1.9e-14 53.6 0.0 2.4e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC37458.1 - 8.5e-06 25.9 0.0 1.6e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC37458.1 - 0.0015 18.6 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase PF00069.25 EFC37459.1 - 1.5e-28 99.9 1.1 2.8e-28 99.0 1.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37459.1 - 5.4e-20 71.8 0.1 9.3e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 EFC37459.1 - 7.5e-07 29.4 0.7 1.8e-06 28.2 0.7 1.8 1 1 0 1 1 1 1 C2 domain DUF4291 PF14124.6 EFC37460.1 - 2.2e-56 190.6 0.6 3.1e-56 190.1 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) ARID PF01388.21 EFC37462.1 - 1.3e-20 73.8 0.3 6e-20 71.7 0.2 2.2 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain DUF4211 PF13926.6 EFC37462.1 - 0.0009 19.3 1.6 0.0037 17.3 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) BAF250_C PF12031.8 EFC37462.1 - 0.2 10.9 3.3 1.6 8.0 0.1 2.9 2 1 0 3 3 3 0 SWI/SNF-like complex subunit BAF250/Osa Metallophos PF00149.28 EFC37463.1 - 2e-31 110.1 0.4 3.1e-31 109.5 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 EFC37463.1 - 1.3e-20 73.5 0.8 2.1e-20 72.8 0.8 1.4 1 0 0 1 1 1 1 PPP5 TPR repeat region LRR_6 PF13516.6 EFC37464.1 - 3.5e-44 145.1 13.6 0.00041 20.2 0.0 10.4 10 0 0 10 10 10 10 Leucine Rich repeat LRR_8 PF13855.6 EFC37464.1 - 1e-27 95.7 5.3 6.9e-08 32.1 0.3 5.0 4 1 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC37464.1 - 2.1e-21 75.7 11.1 0.00055 20.3 1.7 6.9 1 1 6 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37464.1 - 2.7e-14 51.5 0.3 0.55 11.0 0.0 8.4 9 0 0 9 9 9 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC37464.1 - 2.4e-05 23.9 0.2 2.4 7.6 0.0 3.1 1 1 1 3 3 3 2 Leucine-rich repeat DUF4347 PF14252.6 EFC37464.1 - 0.0003 20.7 4.1 12 5.7 0.2 5.5 1 1 4 5 5 5 1 Domain of unknown function (DUF4347) NKWYS PF10364.9 EFC37464.1 - 0.017 15.2 0.4 3.5 7.8 0.0 3.4 3 1 1 4 4 4 0 Putative capsular polysaccharide synthesis protein NOC3p PF07540.11 EFC37464.1 - 0.15 12.6 2.3 6.7 7.2 0.2 3.6 1 1 2 4 4 4 0 Nucleolar complex-associated protein DUF4116 PF13475.6 EFC37465.1 - 1.9e-42 142.8 27.0 1.1e-09 37.9 0.1 10.6 4 2 8 12 12 12 12 Domain of unknown function (DUF4116) CoA_transf_3 PF02515.17 EFC37467.1 - 8e-35 120.6 0.0 4e-34 118.3 0.0 2.0 1 1 0 1 1 1 1 CoA-transferase family III YxiJ PF14176.6 EFC37469.1 - 0.023 15.2 2.4 0.053 14.0 2.4 1.6 1 0 0 1 1 1 0 YxiJ-like protein zf-FCS PF06467.14 EFC37469.1 - 0.17 11.8 3.6 0.5 10.3 3.6 1.8 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DUF3510 PF12022.8 EFC37469.1 - 0.87 10.0 4.0 3.7 8.0 4.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) LRR_6 PF13516.6 EFC37470.1 - 9e-58 187.5 11.1 2.3e-07 30.3 0.1 11.2 11 0 0 11 11 11 10 Leucine Rich repeat LRR_4 PF12799.7 EFC37470.1 - 1.7e-32 110.9 19.6 2e-05 24.9 0.1 7.1 2 1 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37470.1 - 2.1e-31 107.5 27.0 8.5e-09 35.1 0.3 6.1 3 2 4 7 7 7 6 Leucine rich repeat LRR_1 PF00560.33 EFC37470.1 - 5.1e-19 65.9 4.1 3.3 8.6 0.0 11.8 12 0 0 12 12 12 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC37470.1 - 2.3e-09 37.0 1.3 0.0014 18.1 0.2 4.1 1 1 4 5 5 5 5 Leucine-rich repeat DUF4347 PF14252.6 EFC37470.1 - 5.1e-05 23.2 0.5 1.6 8.6 0.0 5.1 2 2 3 5 5 5 1 Domain of unknown function (DUF4347) DUF5490 PF17593.2 EFC37470.1 - 0.0024 17.9 2.4 51 4.0 0.0 6.9 6 2 2 8 8 8 0 Family of unknown function (DUF5490) ApoB100_C PF12491.8 EFC37470.1 - 0.0053 16.7 17.6 4.9 7.2 0.1 8.5 5 3 5 10 10 10 1 Apolipoprotein B100 C terminal LRR_2 PF07723.13 EFC37470.1 - 0.059 14.1 0.1 87 4.0 0.0 4.7 5 0 0 5 5 5 0 Leucine Rich Repeat SAM_2 PF07647.17 EFC37471.1 - 0.0056 16.8 0.2 0.011 15.9 0.0 1.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC37471.1 - 0.017 15.6 0.1 0.026 15.0 0.1 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Methyltransf_25 PF13649.6 EFC37472.1 - 7.1e-14 52.3 0.0 7e-12 45.9 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC37472.1 - 7.4e-13 48.6 0.7 2.3e-12 47.0 0.3 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC37472.1 - 2e-12 47.7 0.0 2.9e-10 40.8 0.0 3.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC37472.1 - 2.1e-12 47.2 0.1 4.1e-12 46.3 0.1 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC37472.1 - 4.3e-12 46.5 0.0 3.3e-10 40.5 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Pox_MCEL PF03291.16 EFC37472.1 - 5.3e-10 38.9 2.2 6.9e-10 38.6 2.2 1.1 1 0 0 1 1 1 1 mRNA capping enzyme Ubie_methyltran PF01209.18 EFC37472.1 - 5.8e-09 35.6 1.2 4.6e-05 22.9 0.4 2.7 2 1 1 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFC37472.1 - 7.7e-06 26.0 0.1 1.5e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 EFC37472.1 - 2.3e-05 24.0 0.1 3.7e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain PCMT PF01135.19 EFC37472.1 - 0.0015 18.4 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPMT PF05724.11 EFC37472.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.5 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) DUF919 PF06034.11 EFC37472.1 - 0.015 15.1 1.9 0.031 14.1 0.5 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Methyltransf_34 PF11312.8 EFC37472.1 - 0.022 14.0 0.1 0.22 10.8 0.1 2.0 1 1 0 1 1 1 0 Putative SAM-dependent methyltransferase NNMT_PNMT_TEMT PF01234.17 EFC37472.1 - 0.058 12.6 0.0 0.099 11.8 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family G-alpha PF00503.20 EFC37473.1 - 5.4e-35 121.2 1.1 6.6e-35 120.9 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC37473.1 - 0.002 17.6 0.0 0.0038 16.7 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFC37474.1 - 7.7e-16 58.2 0.3 1.2e-15 57.6 0.0 1.4 2 0 0 2 2 2 1 G-protein alpha subunit AsnC_trans_reg PF01037.21 EFC37474.1 - 0.18 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain Phage_DsbA PF11126.8 EFC37474.1 - 0.18 12.0 0.4 4 7.7 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulator DsbA Mito_carr PF00153.27 EFC37476.1 - 2.6e-21 75.3 4.9 3.5e-09 36.5 0.1 4.1 4 0 0 4 4 4 3 Mitochondrial carrier protein DUF4116 PF13475.6 EFC37477.1 - 7.1e-58 192.1 13.2 3.4e-11 42.7 0.0 9.4 5 3 5 10 10 10 10 Domain of unknown function (DUF4116) CHASE4 PF05228.13 EFC37478.1 - 6.5e-15 55.6 0.0 1.5e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 CHASE4 domain RGS PF00615.19 EFC37478.1 - 3.2e-10 40.3 3.5 3.2e-10 40.3 3.5 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain PAS_8 PF13188.7 EFC37478.1 - 0.0024 17.9 0.0 0.0083 16.1 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EFC37478.1 - 0.0077 16.5 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain HAMP PF00672.25 EFC37478.1 - 0.0081 16.5 0.0 0.031 14.6 0.0 2.1 1 0 0 1 1 1 1 HAMP domain SP_C-Propep PF08999.10 EFC37478.1 - 0.56 10.0 4.1 3 7.7 0.6 2.3 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide DUF3433 PF11915.8 EFC37478.1 - 0.68 10.4 4.8 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3433) KIAA1430 PF13879.6 EFC37478.1 - 8.7 7.2 16.6 7.5 7.4 9.6 2.8 1 1 0 2 2 2 0 KIAA1430 homologue ORMDL PF04061.14 EFC37479.1 - 9.4e-35 119.4 5.6 2.1e-34 118.2 5.6 1.6 1 1 0 1 1 1 1 ORMDL family SSP160 PF06933.11 EFC37479.1 - 0.052 11.8 2.3 0.07 11.3 2.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3377 PF11857.8 EFC37479.1 - 0.12 12.3 0.8 1.1 9.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) SieB PF14163.6 EFC37479.1 - 0.17 11.3 2.7 0.2 11.2 0.2 2.0 2 0 0 2 2 2 0 Super-infection exclusion protein B DUF4191 PF13829.6 EFC37479.1 - 0.65 9.3 3.4 1.5 8.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Guanylate_cyc PF00211.20 EFC37480.1 - 0.0055 16.3 0.3 0.011 15.4 0.3 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CCG PF02754.16 EFC37480.1 - 0.0091 16.2 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Cysteine-rich domain MIF4G PF02854.19 EFC37481.1 - 0.0028 17.3 5.4 0.0042 16.8 4.4 1.8 2 1 0 2 2 2 1 MIF4G domain SirA PF10747.9 EFC37481.1 - 1.4 9.3 7.8 12 6.2 0.2 3.1 2 2 1 3 3 3 0 Sporulation inhibitor of replication protein SirA Ephrin_rec_like PF07699.13 EFC37482.1 - 4.3 7.2 16.0 9.3e+03 -3.5 16.0 2.8 1 1 0 1 1 1 0 Putative ephrin-receptor like Zn_clus PF00172.18 EFC37483.1 - 1.8e-09 37.6 10.9 3.7e-09 36.6 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_2 PF12796.7 EFC37484.1 - 5.7e-05 23.6 0.3 0.12 13.0 0.1 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC37484.1 - 0.00017 22.0 0.2 1.6 9.4 0.0 3.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC37484.1 - 0.00024 21.3 0.1 3 8.3 0.1 3.7 2 1 0 2 2 2 2 Ankyrin repeats (many copies) F-box PF00646.33 EFC37484.1 - 0.0052 16.6 0.1 0.016 15.0 0.1 1.9 1 0 0 1 1 1 1 F-box domain AP_endonuc_2 PF01261.24 EFC37484.1 - 0.032 13.7 0.0 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel F-box-like PF12937.7 EFC37484.1 - 0.19 11.7 0.7 0.56 10.1 0.1 2.1 2 0 0 2 2 2 0 F-box-like SR-25 PF10500.9 EFC37485.1 - 0.0058 16.3 12.7 0.011 15.4 12.7 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DUF692 PF05114.13 EFC37486.1 - 0.05 12.8 0.2 0.1 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF692) DUF5601 PF18151.1 EFC37486.1 - 0.43 10.9 9.1 2.8 8.3 1.8 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5601) DUF917 PF06032.12 EFC37487.1 - 1.1e-115 386.3 0.0 2e-115 385.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydantoinase_A PF01968.18 EFC37487.1 - 2e-34 119.2 3.3 3.3e-31 108.6 0.2 3.1 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFC37487.1 - 1.3e-25 90.1 0.1 2.3e-24 86.0 0.0 2.9 3 0 0 3 3 3 1 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 EFC37487.1 - 1.1e-07 30.8 2.4 0.0083 14.8 0.1 3.1 3 0 0 3 3 3 2 MutL protein BcrAD_BadFG PF01869.20 EFC37487.1 - 0.00018 21.1 0.1 0.098 12.1 0.0 2.5 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 EFC37487.1 - 0.00026 21.3 0.3 0.43 11.0 0.0 3.7 4 0 0 4 4 4 2 Cell division protein FtsA ROK PF00480.20 EFC37487.1 - 0.055 12.9 0.2 0.13 11.7 0.2 1.7 1 0 0 1 1 1 0 ROK family StbA PF06406.11 EFC37487.1 - 0.068 12.4 7.4 5.7 6.1 0.0 3.9 4 1 0 4 4 4 0 StbA protein FAD_binding_4 PF01565.23 EFC37487.1 - 0.13 12.0 0.0 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 FAD binding domain MreB_Mbl PF06723.13 EFC37487.1 - 0.26 10.1 4.0 5.4 5.7 0.1 3.1 3 0 0 3 3 3 0 MreB/Mbl protein PI3_PI4_kinase PF00454.27 EFC37489.1 - 1.7e-36 126.3 0.0 6.2e-36 124.5 0.0 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC37489.1 - 6e-06 25.8 4.0 6e-06 25.8 4.0 2.9 2 1 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Metallophos PF00149.28 EFC37490.1 - 1.1e-12 48.9 2.5 1.8e-12 48.2 2.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC37490.1 - 5e-08 33.3 3.4 1.4e-07 31.8 1.7 2.4 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain CBAH PF02275.18 EFC37490.1 - 0.032 13.9 1.0 0.054 13.1 0.2 1.7 2 0 0 2 2 2 0 Linear amide C-N hydrolases, choloylglycine hydrolase family GARS_N PF02844.15 EFC37490.1 - 0.049 14.4 0.0 0.15 12.9 0.0 1.8 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain RRM PF10378.9 EFC37490.1 - 0.1 12.4 0.1 0.28 10.9 0.1 1.7 1 0 0 1 1 1 0 Putative RRM domain Trypan_PARP PF05887.11 EFC37492.1 - 2.4e-06 27.6 118.6 1.8e+04 -60.4 118.6 3.5 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_S10 PF00450.22 EFC37493.1 - 3.2e-35 122.4 1.0 4.3e-35 121.9 0.2 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase EGF_2 PF07974.13 EFC37493.1 - 0.11 12.9 10.5 0.23 11.8 10.5 1.5 1 0 0 1 1 1 0 EGF-like domain UB2H PF14814.6 EFC37494.1 - 0.0021 18.0 0.6 0.012 15.6 0.0 2.5 2 0 0 2 2 2 1 Bifunctional transglycosylase second domain CHAP PF05257.16 EFC37494.1 - 0.15 12.6 1.0 0.28 11.8 0.1 1.9 2 0 0 2 2 2 0 CHAP domain SOG2 PF10428.9 EFC37494.1 - 1.8 7.7 32.7 2.2 7.4 32.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein TFIIA PF03153.13 EFC37494.1 - 5.3 6.9 18.9 6.4 6.6 18.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit HSCB_C PF07743.13 EFC37495.1 - 0.041 14.4 0.4 2.2 8.9 0.1 2.4 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain FtsH_ext PF06480.15 EFC37495.1 - 0.099 13.0 0.1 3.6 8.0 0.0 2.8 3 0 0 3 3 3 0 FtsH Extracellular Metallophos PF00149.28 EFC37496.1 - 0.0012 19.4 0.0 0.0014 19.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ras PF00071.22 EFC37497.1 - 1.4e-30 106.0 0.1 2e-30 105.5 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37497.1 - 3.9e-13 49.7 0.0 1e-12 48.3 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC37497.1 - 8.9e-11 41.5 0.0 1.3e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC37497.1 - 4e-06 26.8 0.1 0.0016 18.3 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EFC37497.1 - 0.0001 21.6 0.4 0.32 10.1 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 EFC37497.1 - 0.00022 20.8 0.1 0.00027 20.6 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC37497.1 - 0.0031 16.9 0.9 0.0073 15.7 0.9 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EFC37497.1 - 0.0089 15.6 1.4 0.88 9.1 0.2 3.1 2 1 1 3 3 3 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EFC37497.1 - 0.024 14.4 0.5 0.11 12.3 0.4 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF4375 PF14300.6 EFC37497.1 - 0.04 14.2 0.1 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) MeaB PF03308.16 EFC37497.1 - 0.087 11.8 0.2 0.31 10.0 0.1 1.8 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB LMP PF04778.12 EFC37497.1 - 0.099 12.6 4.2 0.17 11.8 4.2 1.4 1 0 0 1 1 1 0 LMP repeated region MMR_HSR1_Xtn PF16897.5 EFC37497.1 - 0.18 11.8 2.1 0.52 10.3 1.2 2.1 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 EFC37497.1 - 0.43 9.9 3.1 0.3 10.4 0.5 2.0 1 1 1 2 2 2 0 AIG1 family Sel1 PF08238.12 EFC37498.1 - 5.4e-33 112.7 16.7 4.3e-06 27.2 0.8 8.1 8 0 0 8 8 8 7 Sel1 repeat F-box-like PF12937.7 EFC37498.1 - 0.0014 18.5 0.1 0.0025 17.7 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37498.1 - 0.0034 17.2 0.0 0.0074 16.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain ZZ PF00569.17 EFC37498.1 - 0.18 11.6 22.2 0.2 11.5 14.4 2.6 1 1 1 2 2 2 0 Zinc finger, ZZ type LRR_4 PF12799.7 EFC37498.1 - 0.26 11.8 7.4 0.2 12.1 3.8 2.7 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37498.1 - 3.7 8.5 4.9 8.6 7.4 0.0 3.9 5 0 0 5 5 5 0 Leucine Rich Repeat EGF_2 PF07974.13 EFC37499.1 - 8.9e-15 54.8 151.3 0.00029 21.1 5.6 10.5 10 0 0 10 10 10 9 EGF-like domain Jacalin PF01419.17 EFC37499.1 - 0.053 13.5 3.1 0.13 12.2 3.1 1.6 1 0 0 1 1 1 0 Jacalin-like lectin domain DASH_Dad1 PF08649.10 EFC37500.1 - 0.051 13.8 0.4 0.19 11.9 0.4 2.0 1 0 0 1 1 1 0 DASH complex subunit Dad1 Zn_clus PF00172.18 EFC37500.1 - 0.76 10.0 5.8 0.13 12.4 1.7 1.9 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain NHL PF01436.21 EFC37501.1 - 4.8e-48 158.9 0.1 0.0018 18.2 0.0 12.2 12 0 0 12 12 12 11 NHL repeat EGF_2 PF07974.13 EFC37501.1 - 5e-12 46.0 37.6 3.9e-05 23.9 8.6 3.6 3 0 0 3 3 3 3 EGF-like domain Phytase-like PF13449.6 EFC37501.1 - 0.00017 21.7 0.4 1.2 9.0 0.0 4.0 3 2 1 4 4 4 2 Esterase-like activity of phytase SGL PF08450.12 EFC37501.1 - 0.0013 18.3 7.3 0.27 10.8 1.5 4.6 3 2 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region EGF PF00008.27 EFC37501.1 - 1.4 9.3 31.8 2.7 8.4 4.8 3.7 3 0 0 3 3 3 0 EGF-like domain hEGF PF12661.7 EFC37501.1 - 3.9 8.2 46.7 0.46 11.2 5.9 4.3 4 0 0 4 4 4 0 Human growth factor-like EGF APG6 PF04111.12 EFC37502.1 - 5.5e-42 143.7 0.0 1.1e-41 142.8 0.0 1.5 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 EFC37502.1 - 7.4e-08 33.0 10.2 1.5e-07 32.0 10.2 1.6 1 0 0 1 1 1 1 Apg6 coiled-coil region GFA PF04828.14 EFC37502.1 - 0.11 12.8 0.1 11 6.4 0.1 2.6 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-C4H2 PF10146.9 EFC37502.1 - 1.6 9.0 6.4 3 8.1 6.4 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein FXMRP1_C_core PF12235.8 EFC37502.1 - 2.5 8.7 6.4 1.2 9.8 2.2 2.2 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal DUF5401 PF17380.2 EFC37502.1 - 6.6 4.7 11.9 8.7 4.3 11.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Beta_helix PF13229.6 EFC37504.1 - 0.0016 18.3 17.6 0.0016 18.3 17.6 4.6 4 1 1 5 5 5 2 Right handed beta helix region HSP70 PF00012.20 EFC37505.1 - 9.5e-22 76.9 0.5 1.9e-19 69.3 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein HSP70 PF00012.20 EFC37506.1 - 7.3e-10 37.7 0.2 7.8e-10 37.6 0.2 1.0 1 0 0 1 1 1 1 Hsp70 protein PhoD PF09423.10 EFC37506.1 - 0.17 10.9 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 PhoD-like phosphatase DUF4116 PF13475.6 EFC37507.1 - 1.1e-156 508.5 82.9 8.5e-14 51.0 0.0 24.2 13 5 14 27 27 27 22 Domain of unknown function (DUF4116) NitrOD1 PF18549.1 EFC37507.1 - 0.049 13.6 0.2 18 5.4 0.0 3.8 3 0 0 3 3 3 0 Nitrosopumilus output domain 1 GLTP PF08718.11 EFC37507.1 - 0.46 10.7 5.1 37 4.6 0.0 4.7 4 1 0 5 5 5 0 Glycolipid transfer protein (GLTP) DUF1154 PF06631.11 EFC37507.1 - 3.2 7.9 7.9 1.7 8.7 0.0 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF1154) DUF4209 PF13910.6 EFC37508.1 - 4.9e-28 97.2 3.4 5.3e-24 84.3 0.2 3.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4209) Vps39_2 PF10367.9 EFC37508.1 - 8.5e-11 42.3 3.1 1.9e-10 41.2 0.3 3.1 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CdiI_2 PF18593.1 EFC37508.1 - 0.46 11.2 4.1 1.9 9.2 0.0 3.8 2 0 0 2 2 2 0 CdiI immunity protein Tropomyosin_1 PF12718.7 EFC37509.1 - 0.016 15.4 0.8 0.034 14.3 0.4 1.7 2 0 0 2 2 2 0 Tropomyosin like Laminin_II PF06009.12 EFC37509.1 - 0.018 15.0 0.5 0.018 15.0 0.5 2.5 2 1 0 2 2 2 0 Laminin Domain II PI3K_P85_iSH2 PF16454.5 EFC37509.1 - 0.071 12.7 0.4 0.12 11.9 0.4 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF5595 PF18077.1 EFC37509.1 - 0.17 12.0 0.4 4.5 7.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) DUF16 PF01519.16 EFC37509.1 - 0.31 11.6 1.9 1.1 9.7 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF16 TMF_TATA_bd PF12325.8 EFC37509.1 - 0.43 10.8 2.7 0.45 10.7 0.5 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 EFC37509.1 - 0.72 9.9 5.5 0.35 10.9 1.4 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) YojJ PF10372.9 EFC37509.1 - 2.6 8.2 5.6 84 3.4 0.1 3.5 3 1 1 4 4 4 0 Bacterial membrane-spanning protein N-terminus Abhydrolase_6 PF12697.7 EFC37510.1 - 0.025 15.2 0.0 0.046 14.3 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.12 EFC37510.1 - 0.029 13.9 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LIDHydrolase PF10230.9 EFC37510.1 - 0.033 13.7 0.1 0.087 12.4 0.0 1.7 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Pantoate_ligase PF02569.15 EFC37511.1 - 4.9e-77 258.7 0.0 6.6e-77 258.3 0.0 1.1 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Pkinase_fungal PF17667.1 EFC37513.1 - 3.2e-09 36.1 0.2 5.4e-09 35.3 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 EFC37513.1 - 1.6e-06 27.7 2.4 4e-06 26.4 2.4 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37513.1 - 0.0045 16.3 0.3 0.0084 15.4 0.3 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase TIMELESS PF04821.14 EFC37514.1 - 2e-15 56.8 13.2 2e-15 56.8 13.2 4.7 3 2 1 4 4 4 1 Timeless protein CYYR1 PF10873.8 EFC37518.1 - 0.098 13.1 5.1 0.11 13.0 3.9 1.6 1 1 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 SPRY PF00622.28 EFC37519.1 - 2.9e-07 30.6 0.2 3.8e-07 30.2 0.2 1.2 1 0 0 1 1 1 1 SPRY domain ZZ PF00569.17 EFC37520.1 - 6.8e-15 54.6 26.5 4.4e-08 32.8 7.5 3.1 3 0 0 3 3 3 2 Zinc finger, ZZ type F-box-like PF12937.7 EFC37520.1 - 0.0027 17.6 0.0 0.0068 16.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like C1_2 PF03107.16 EFC37520.1 - 0.54 10.6 29.7 0.2 12.0 10.3 3.6 3 1 0 3 3 3 0 C1 domain DUF4412 PF14371.6 EFC37520.1 - 0.61 9.9 3.1 1.5 8.6 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4412) Cyt-b5 PF00173.28 EFC37522.1 - 5.2e-13 48.9 0.2 6.8e-13 48.6 0.2 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Copine PF07002.16 EFC37523.1 - 5.2e-49 166.6 0.5 2.3e-48 164.5 0.5 2.0 1 1 0 1 1 1 1 Copine C2 PF00168.30 EFC37523.1 - 6.5e-21 74.6 0.2 1.1e-10 41.7 0.0 2.6 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFC37523.1 - 0.00026 21.1 0.1 0.002 18.3 0.0 2.3 2 0 0 2 2 2 1 vWA found in TerF C terminus Post_transc_reg PF13797.6 EFC37523.1 - 0.088 12.7 0.2 0.39 10.6 0.1 2.1 2 0 0 2 2 2 0 Post-transcriptional regulator GSAP-16 PF14959.6 EFC37524.1 - 1.2e-10 41.2 0.1 1.2e-10 41.2 0.1 2.0 2 0 0 2 2 2 1 gamma-Secretase-activating protein C-term DUF4112 PF13430.6 EFC37526.1 - 5.3e-29 100.6 2.1 6.7e-29 100.3 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DUF962 PF06127.11 EFC37527.1 - 2.4e-33 114.1 1.4 2.7e-33 113.9 1.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF962) p450 PF00067.22 EFC37528.1 - 9.2e-61 206.0 0.0 1.2e-60 205.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EFC37529.1 - 1.3e-48 165.9 0.0 1.3e-37 129.7 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 PhzC-PhzF PF02567.16 EFC37530.1 - 2.3e-53 181.5 0.0 5.4e-53 180.3 0.0 1.7 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Peptidase_S9 PF00326.21 EFC37532.1 - 1.9e-31 109.2 0.0 2.9e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC37532.1 - 1.4e-08 34.7 0.5 2.2e-07 30.8 0.6 2.4 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC37532.1 - 1.2e-07 31.3 0.1 3.5e-05 23.2 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFC37532.1 - 0.014 15.3 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Pkinase PF00069.25 EFC37533.1 - 6.3e-45 153.6 3.0 6.3e-45 153.6 3.0 4.1 4 1 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37533.1 - 9.7e-26 90.6 6.7 2e-20 73.2 0.5 4.3 4 0 0 4 4 4 2 Protein tyrosine kinase Kinesin PF00225.23 EFC37533.1 - 2.8e-18 65.9 0.1 2.8e-18 65.9 0.1 3.6 3 1 0 3 3 3 1 Kinesin motor domain SAM_2 PF07647.17 EFC37533.1 - 8.2e-14 51.5 0.2 2.7e-13 49.8 0.2 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC37533.1 - 2.3e-13 50.4 1.4 2e-12 47.3 0.2 2.9 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) Microtub_bd PF16796.5 EFC37533.1 - 5.5e-07 29.6 0.1 3.7e-06 27.0 0.1 2.6 1 0 0 1 1 1 1 Microtubule binding SAM_PNT PF02198.16 EFC37533.1 - 0.0029 17.5 0.3 0.0088 16.0 0.3 1.9 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SMC_N PF02463.19 EFC37534.1 - 1.2e-56 191.6 34.9 1.9e-56 191.0 34.9 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFC37534.1 - 3.8e-19 70.0 11.8 3.8e-19 70.0 11.8 5.1 2 1 2 4 4 4 1 AAA domain AAA_21 PF13304.6 EFC37534.1 - 3.9e-16 59.7 6.2 1.3e-08 35.0 0.5 3.5 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_hinge PF06470.13 EFC37534.1 - 3.6e-15 56.3 0.0 1.2e-14 54.6 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EFC37534.1 - 7e-10 39.1 9.3 7e-10 39.1 9.3 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 EFC37534.1 - 0.00078 19.1 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 EFC37534.1 - 0.01 15.4 0.1 0.01 15.4 0.1 4.1 5 0 0 5 5 5 0 AAA domain FtsK_SpoIIIE PF01580.18 EFC37534.1 - 0.05 13.0 0.4 0.33 10.3 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Ribosomal_L5_C PF00673.21 EFC37536.1 - 6.4e-22 77.5 0.0 9.8e-22 77.0 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 EFC37536.1 - 6.8e-18 64.7 0.0 1.3e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 EF-hand_7 PF13499.6 EFC37537.1 - 0.025 15.0 2.3 3.6 8.1 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 EFC37537.1 - 0.52 10.4 3.3 1 9.4 0.2 2.9 2 2 0 2 2 2 0 EF-hand domain dNK PF01712.19 EFC37538.1 - 6.7e-27 94.7 4.6 9.8e-27 94.1 4.6 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 EFC37538.1 - 6.5e-06 25.9 0.3 0.11 12.1 0.0 2.4 2 0 0 2 2 2 2 Thymidylate kinase AAA_17 PF13207.6 EFC37538.1 - 0.001 19.5 0.5 0.11 12.9 0.5 2.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC37538.1 - 0.0032 18.0 1.3 0.027 15.0 1.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC37538.1 - 0.0064 16.7 0.0 0.11 12.6 0.0 2.7 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EFC37538.1 - 0.034 14.2 0.2 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EFC37538.1 - 0.077 13.5 0.2 0.21 12.1 0.2 1.8 1 1 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 EFC37538.1 - 0.089 12.6 0.8 0.27 11.0 0.0 2.1 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Cytidylate_kin PF02224.18 EFC37538.1 - 0.11 12.2 0.0 0.96 9.1 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase Complex1_LYR_2 PF13233.6 EFC37538.1 - 3.8 8.3 5.3 1.6 9.5 1.9 2.5 2 2 1 3 3 3 0 Complex1_LYR-like RINGv PF12906.7 EFC37539.1 - 6.8e-17 61.3 8.3 1.2e-16 60.6 8.3 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 EFC37539.1 - 0.0082 16.5 8.1 0.014 15.7 8.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EFC37539.1 - 0.019 15.0 3.3 0.039 14.0 3.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4501 PF14946.6 EFC37539.1 - 0.27 11.3 0.9 0.83 9.7 0.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) Ctr PF04145.15 EFC37539.1 - 0.32 11.6 11.4 0.72 10.5 0.5 4.2 4 1 0 4 4 4 0 Ctr copper transporter family Baculo_IE-1 PF05290.11 EFC37539.1 - 0.57 10.1 6.0 0.17 11.9 2.4 2.0 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 EFC37539.1 - 1.9 8.3 9.1 3.5 7.5 9.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PNISR PF15996.5 EFC37539.1 - 2.3 8.4 16.8 0.28 11.4 6.2 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Tim54 PF11711.8 EFC37539.1 - 6.7 5.4 14.4 0.02 13.7 4.8 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 TB2_DP1_HVA22 PF03134.19 EFC37540.1 - 2.2e-06 27.5 8.4 2.2e-06 27.5 8.4 1.9 1 1 1 2 2 2 1 TB2/DP1, HVA22 family DASH_Duo1 PF08651.10 EFC37540.1 - 0.028 14.2 0.1 0.055 13.3 0.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Duo1 Yuri_gagarin PF15934.5 EFC37540.1 - 0.091 12.6 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Yuri gagarin ArfGap PF01412.18 EFC37541.1 - 1e-38 132.0 0.5 1e-38 132.0 0.5 2.7 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf GAGA_bind PF06217.12 EFC37541.1 - 0.15 12.3 17.5 0.17 12.2 6.8 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family TEX19 PF15553.6 EFC37541.1 - 1.9 8.5 6.0 0.83 9.6 1.9 2.4 3 0 0 3 3 3 0 Testis-expressed protein 19 WD40 PF00400.32 EFC37542.1 - 4.9e-10 39.8 11.5 0.00018 22.2 0.2 5.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC37542.1 - 0.0012 19.1 0.0 0.53 10.6 0.0 3.9 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain FBA_3 PF08268.12 EFC37542.1 - 0.027 14.4 0.0 0.34 10.9 0.0 2.3 2 0 0 2 2 2 0 F-box associated domain ELYS-bb PF16687.5 EFC37542.1 - 0.041 12.5 0.0 1.8 7.1 0.0 2.2 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin DUF5520 PF17658.1 EFC37542.1 - 0.054 12.6 0.5 0.097 11.8 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5520) DNA_pol_phi PF04931.13 EFC37542.1 - 6.7 4.7 10.6 9.1 4.2 10.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi BACK PF07707.15 EFC37543.1 - 9.4e-18 64.2 0.7 3.3e-16 59.3 0.3 2.2 2 0 0 2 2 2 1 BTB And C-terminal Kelch Zn_clus PF00172.18 EFC37543.1 - 7.2e-07 29.2 6.8 1.5e-06 28.2 6.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BTB PF00651.31 EFC37543.1 - 2.1e-05 24.7 0.0 4.6e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain HypA PF01155.19 EFC37543.1 - 0.47 10.5 3.5 1 9.4 3.5 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA FeoC PF09012.10 EFC37543.1 - 7.5 6.7 6.2 5.7 7.1 3.2 2.3 3 0 0 3 3 3 0 FeoC like transcriptional regulator Pkinase_Tyr PF07714.17 EFC37544.1 - 5.3e-49 166.8 0.0 2e-48 165.0 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC37544.1 - 2.7e-44 151.5 0.0 5e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Beta_helix PF13229.6 EFC37544.1 - 3.8e-09 36.6 22.6 6.3e-06 26.1 6.1 3.9 1 1 2 3 3 3 3 Right handed beta helix region Chlam_PMP PF02415.17 EFC37544.1 - 8.9e-08 32.2 19.3 0.059 13.9 1.1 6.3 5 0 0 5 5 5 3 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat APH PF01636.23 EFC37544.1 - 0.00094 19.2 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF5123 PF17161.4 EFC37544.1 - 5 8.2 17.4 2 9.5 1.8 4.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5123) RGS PF00615.19 EFC37545.1 - 7.5e-14 52.0 2.6 7.5e-14 52.0 2.6 2.7 2 1 1 3 3 3 1 Regulator of G protein signaling domain DUF1935 PF09149.10 EFC37545.1 - 0.056 13.8 0.3 0.27 11.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1935) LRR_6 PF13516.6 EFC37546.1 - 5.8e-09 35.3 0.2 0.15 12.2 0.0 5.4 4 0 0 4 4 4 2 Leucine Rich repeat F-box-like PF12937.7 EFC37546.1 - 0.014 15.2 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 EFC37546.1 - 0.036 14.5 6.3 6.9 7.2 0.0 5.1 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) ABC_tran PF00005.27 EFC37547.1 - 5.8e-33 114.3 0.0 8.9e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC37547.1 - 9.7e-08 31.7 0.7 6.3e-05 22.5 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC37547.1 - 9.8e-06 26.1 0.0 2.4e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC37547.1 - 0.00028 20.6 0.1 0.00062 19.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF87 PF01935.17 EFC37547.1 - 0.00074 19.7 1.1 0.065 13.3 0.1 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 EFC37547.1 - 0.0013 19.0 0.1 0.0064 16.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC37547.1 - 0.0023 18.4 0.5 0.034 14.6 0.5 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EFC37547.1 - 0.0062 16.3 0.0 0.016 15.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC37547.1 - 0.0082 16.1 0.0 0.03 14.2 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_15 PF13175.6 EFC37547.1 - 0.013 15.2 0.0 0.026 14.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EFC37547.1 - 0.028 14.4 0.1 0.14 12.2 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EFC37547.1 - 0.049 12.4 0.1 0.11 11.3 0.0 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_7 PF12775.7 EFC37547.1 - 0.057 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EFC37547.1 - 0.15 12.6 0.4 0.32 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFC37547.1 - 0.19 11.0 0.0 0.51 9.6 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin RRM_2 PF04059.12 EFC37548.1 - 1e-47 160.3 1.8 2.2e-47 159.2 1.8 1.6 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 EFC37548.1 - 4.7e-28 96.8 7.8 2.7e-12 46.3 0.5 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC37548.1 - 4e-07 29.7 0.0 1.1e-05 25.0 0.0 2.6 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC37548.1 - 4.5e-07 29.6 0.1 0.0063 16.4 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif BRAP2 PF07576.12 EFC37548.1 - 0.0071 16.5 1.6 0.071 13.3 0.3 2.6 2 0 0 2 2 2 1 BRCA1-associated protein 2 Nup35_RRM_2 PF14605.6 EFC37548.1 - 0.016 15.2 0.1 0.71 9.9 0.0 2.6 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Smg4_UPF3 PF03467.15 EFC37548.1 - 0.039 14.0 2.1 0.062 13.3 0.3 2.2 2 0 0 2 2 2 0 Smg-4/UPF3 family Limkain-b1 PF11608.8 EFC37548.1 - 0.044 13.9 0.0 0.16 12.0 0.0 2.0 1 0 0 1 1 1 0 Limkain b1 PHM7_cyt PF14703.6 EFC37548.1 - 0.07 13.4 5.1 11 6.3 3.0 3.4 2 1 1 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DbpA PF03880.15 EFC37548.1 - 0.086 12.8 1.6 0.2 11.7 0.1 2.2 2 0 0 2 2 2 0 DbpA RNA binding domain Pantoate_transf PF02548.15 EFC37549.1 - 4.3e-100 334.4 0.1 6.2e-100 333.9 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase ApbA_C PF08546.11 EFC37549.1 - 3.2e-29 101.7 1.4 7.2e-29 100.5 1.4 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 EFC37549.1 - 8.1e-17 61.3 0.2 1.7e-16 60.2 0.2 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA PEP_mutase PF13714.6 EFC37549.1 - 0.00014 21.4 0.3 0.00041 19.9 0.3 1.8 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase NAD_Gly3P_dh_N PF01210.23 EFC37549.1 - 0.00071 19.6 0.3 0.002 18.1 0.3 1.8 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.6 EFC37549.1 - 0.0013 19.1 0.1 0.0066 16.9 0.0 2.2 2 0 0 2 2 2 1 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 EFC37549.1 - 0.024 14.9 0.1 0.066 13.5 0.1 1.8 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 EFC37549.1 - 0.04 14.2 0.1 0.22 11.8 0.1 2.3 1 1 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 EFC37549.1 - 0.05 14.2 1.2 0.27 11.9 1.2 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Pox_E10 PF04805.12 EFC37552.1 - 0.015 15.1 0.1 0.029 14.2 0.1 1.4 1 0 0 1 1 1 0 E10-like protein conserved region Arginase PF00491.21 EFC37553.1 - 9.6e-55 186.0 0.0 1.4e-54 185.5 0.0 1.3 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EFC37553.1 - 0.022 15.0 0.5 2.4 8.3 0.1 2.5 1 1 1 3 3 3 0 UPF0489 domain Ca_chan_IQ PF08763.11 EFC37553.1 - 0.025 14.8 0.0 0.052 13.8 0.0 1.4 1 0 0 1 1 1 0 Voltage gated calcium channel IQ domain GRP PF07172.11 EFC37554.1 - 0.0047 17.6 28.1 0.0047 17.6 28.1 3.4 1 1 2 3 3 1 1 Glycine rich protein family Neur_chan_memb PF02932.16 EFC37554.1 - 0.0048 17.0 1.0 0.0089 16.1 1.0 1.5 1 1 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SAPS PF04499.15 EFC37554.1 - 0.011 14.6 0.1 0.012 14.4 0.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Apt1 PF10351.9 EFC37554.1 - 0.032 13.1 16.3 0.039 12.8 16.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DDHD PF02862.17 EFC37554.1 - 0.068 13.3 6.9 0.1 12.7 6.9 1.3 1 0 0 1 1 1 0 DDHD domain DUF4614 PF15391.6 EFC37554.1 - 0.076 13.0 20.2 0.14 12.1 20.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Transformer PF06495.11 EFC37554.1 - 0.15 12.2 15.2 0.24 11.5 15.2 1.4 1 0 0 1 1 1 0 Fruit fly transformer protein Zip PF02535.22 EFC37554.1 - 0.47 9.6 7.1 0.52 9.5 5.9 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter NPR3 PF03666.13 EFC37554.1 - 0.66 8.7 17.5 0.88 8.3 17.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SOBP PF15279.6 EFC37554.1 - 1.8 9.1 18.0 2.4 8.7 18.0 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 EFC37554.1 - 2.8 6.6 14.5 4.7 5.9 14.5 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EFC37554.1 - 5.2 5.6 13.9 7.2 5.2 13.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RP-C_C PF11800.8 EFC37554.1 - 9 6.3 9.0 14 5.7 9.0 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region GREB1 PF15782.5 EFC37554.1 - 9.1 3.3 15.8 11 3.0 15.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Rieske PF00355.26 EFC37555.1 - 1.2e-21 76.4 0.0 2.7e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 EFC37555.1 - 1.5e-11 44.2 0.0 3.1e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Pheophorbide a oxygenase YMF19 PF02326.15 EFC37556.1 - 0.11 13.3 2.0 0.12 13.2 0.3 2.0 2 0 0 2 2 2 0 Plant ATP synthase F0 Fibrillarin PF01269.17 EFC37557.1 - 5.5e-21 74.7 0.0 6.6e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin MTS PF05175.14 EFC37557.1 - 0.026 14.1 0.1 0.091 12.3 0.1 1.9 1 1 0 1 1 1 0 Methyltransferase small domain BTB PF00651.31 EFC37558.1 - 3.7e-17 62.5 14.1 2.6e-13 50.2 1.5 4.4 3 2 0 3 3 3 2 BTB/POZ domain NPR3 PF03666.13 EFC37559.1 - 0.3 9.8 10.0 0.42 9.4 10.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 EFC37559.1 - 0.81 8.5 10.0 1 8.2 10.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Zip PF02535.22 EFC37559.1 - 2.3 7.3 4.3 3.9 6.6 4.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter ThrE PF06738.12 EFC37560.1 - 9.8e-38 129.9 19.4 2.9e-37 128.3 3.3 2.3 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EFC37560.1 - 4.6e-11 43.0 25.9 5.2e-09 36.3 8.8 2.3 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE Ribosomal_L27 PF01016.19 EFC37560.1 - 0.0046 17.0 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal L27 protein TBCA PF02970.16 EFC37560.1 - 0.086 13.2 3.3 0.16 12.3 1.1 2.3 2 0 0 2 2 2 0 Tubulin binding cofactor A Rick_17kDa_Anti PF05433.15 EFC37560.1 - 0.19 11.6 0.6 0.39 10.6 0.6 1.5 1 0 0 1 1 1 0 Glycine zipper 2TM domain DUF2568 PF10823.8 EFC37560.1 - 6.5 7.1 7.0 1.1 9.5 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2568) CLPTM1 PF05602.12 EFC37561.1 - 9.7e-130 433.4 9.3 1.3e-129 433.0 9.3 1.2 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 EFC37561.1 - 0.00016 21.3 4.7 0.011 15.5 0.5 2.9 2 0 0 2 2 2 2 PQ loop repeat DUF4834 PF16118.5 EFC37561.1 - 0.056 14.4 1.8 13 6.8 0.0 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Mrx7 PF10906.8 EFC37561.1 - 0.094 13.0 1.9 0.25 11.6 0.2 2.5 2 0 0 2 2 2 0 MIOREX complex component 7 2TM PF13239.6 EFC37561.1 - 0.11 12.8 5.8 0.13 12.6 0.3 2.8 2 0 0 2 2 2 0 2TM domain MtN3_slv PF03083.16 EFC37561.1 - 0.99 9.5 10.6 0.83 9.7 1.6 2.6 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange LPMO_10 PF03067.15 EFC37562.1 - 4e-09 37.4 2.4 3.5e-08 34.3 2.4 2.2 1 1 1 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Smoa_sbd PF17885.1 EFC37562.1 - 0.036 14.2 0.0 0.051 13.7 0.0 1.2 1 0 0 1 1 1 0 Styrene monooxygenase A putative substrate binding domain Ribosomal_S6e PF01092.19 EFC37563.1 - 2.2e-31 108.4 0.0 4e-31 107.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S6e Mito_carr PF00153.27 EFC37565.1 - 3.5e-56 187.1 3.1 2.6e-21 75.3 0.0 4.1 2 1 1 3 3 3 3 Mitochondrial carrier protein LapA_dom PF06305.11 EFC37565.1 - 0.086 12.7 0.0 0.78 9.6 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Choline_transpo PF04515.12 EFC37566.1 - 2.3e-77 260.4 35.3 2.3e-77 260.4 35.3 3.6 4 0 0 4 4 4 1 Plasma-membrane choline transporter TMEM239 PF15841.5 EFC37566.1 - 0.011 15.7 0.6 0.011 15.7 0.6 2.8 2 0 0 2 2 2 0 Transmembrane protein 239 family UDPGT PF00201.18 EFC37567.1 - 9.2e-17 61.0 0.0 1.4e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFC37567.1 - 6.1e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Actin PF00022.19 EFC37569.1 - 2e-101 339.6 0.0 2.7e-100 335.9 0.0 1.9 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EFC37569.1 - 0.09 13.2 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Cell division protein FtsA Pkinase PF00069.25 EFC37570.1 - 5.4e-47 160.4 0.1 9.8e-47 159.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37570.1 - 4.3e-45 154.0 0.0 2.2e-40 138.6 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase NHL PF01436.21 EFC37570.1 - 4e-23 80.2 5.3 2.7e-07 30.3 0.2 8.2 8 0 0 8 8 8 6 NHL repeat EGF_2 PF07974.13 EFC37570.1 - 5.8e-12 45.8 55.9 0.0003 21.1 9.0 4.6 4 0 0 4 4 4 4 EGF-like domain SGL PF08450.12 EFC37570.1 - 0.00019 21.1 1.1 5.6 6.5 0.0 5.2 4 2 1 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region APH PF01636.23 EFC37570.1 - 0.26 11.2 0.1 0.44 10.4 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Frankia_peptide PF14407.6 EFC37571.1 - 0.18 11.8 2.8 9.1 6.3 0.0 3.3 3 0 0 3 3 3 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. 2-Hacid_dh_C PF02826.19 EFC37572.1 - 2e-46 157.6 0.0 8.9e-46 155.5 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFC37572.1 - 1.3e-25 89.6 0.0 2.1e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ABA_GPCR PF12430.8 EFC37573.1 - 0.0062 16.3 0.7 0.0093 15.7 0.7 1.2 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor RGS PF00615.19 EFC37576.1 - 1.1e-09 38.5 4.7 2.6e-09 37.4 4.7 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain TPR_2 PF07719.17 EFC37578.1 - 7.6e-37 122.5 46.9 0.0011 18.9 0.2 18.2 17 0 0 17 17 17 10 Tetratricopeptide repeat TPR_19 PF14559.6 EFC37578.1 - 1.6e-24 86.2 20.2 0.00041 20.8 0.0 13.2 8 4 3 11 11 11 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC37578.1 - 2.2e-24 84.2 54.4 9.9e-05 22.0 0.1 17.8 18 0 0 18 18 18 7 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37578.1 - 1.5e-19 70.3 0.4 0.011 16.4 0.6 8.7 8 1 1 9 9 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFC37578.1 - 5.3e-16 57.9 6.3 4.3 8.4 0.0 13.3 10 4 7 17 17 13 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37578.1 - 2.9e-15 55.7 15.4 0.0017 18.0 0.1 9.2 7 2 3 10 10 10 4 TPR repeat ANAPC3 PF12895.7 EFC37578.1 - 6.8e-13 48.6 48.3 0.0018 18.4 0.2 10.1 10 2 2 12 12 10 5 Anaphase-promoting complex, cyclosome, subunit 3 Kelch_1 PF01344.25 EFC37578.1 - 1.4e-12 47.0 6.9 5.3e-05 22.7 0.1 4.5 5 0 0 5 5 4 3 Kelch motif TPR_8 PF13181.6 EFC37578.1 - 8.3e-12 44.3 44.5 0.031 14.5 0.2 15.7 16 0 0 16 16 14 4 Tetratricopeptide repeat Kelch_3 PF13415.6 EFC37578.1 - 2e-10 40.7 0.5 2e-06 27.9 0.0 4.0 3 0 0 3 3 3 2 Galactose oxidase, central domain GRAM PF02893.20 EFC37578.1 - 4.2e-10 39.5 10.1 2.9e-05 23.9 2.5 3.5 2 0 0 2 2 2 2 GRAM domain TPR_12 PF13424.6 EFC37578.1 - 1.4e-09 38.1 29.8 0.17 12.2 2.3 12.5 11 5 2 15 15 13 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC37578.1 - 4.4e-09 36.4 0.2 0.64 10.2 0.0 6.7 5 1 1 6 6 6 2 Tetratricopeptide repeat Kelch_6 PF13964.6 EFC37578.1 - 7.3e-09 35.6 2.9 0.00056 20.1 0.0 4.4 4 0 0 4 4 4 2 Kelch motif TPR_15 PF13429.6 EFC37578.1 - 1.2e-07 31.2 12.4 0.079 12.2 0.3 6.4 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC37578.1 - 3.2e-07 29.9 8.9 0.11 12.6 0.2 9.5 12 0 0 12 12 10 1 Tetratricopeptide repeat Kelch_4 PF13418.6 EFC37578.1 - 5.7e-07 29.4 7.3 0.00095 19.1 0.1 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain DUF627 PF04781.12 EFC37578.1 - 1.5e-05 25.0 11.9 0.51 10.4 0.1 6.6 7 0 0 7 7 7 2 Protein of unknown function (DUF627) Kelch_5 PF13854.6 EFC37578.1 - 0.00027 20.9 0.7 1.4 9.0 0.0 4.4 4 0 0 4 4 4 1 Kelch motif TPR_6 PF13174.6 EFC37578.1 - 0.00056 20.4 17.3 19 6.1 0.0 11.2 12 0 0 12 12 9 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC37578.1 - 0.0048 16.3 5.1 0.85 8.9 0.0 3.5 3 1 0 3 3 3 1 MalT-like TPR region Membr_traf_MHD PF10540.9 EFC37578.1 - 0.008 16.4 0.1 0.008 16.4 0.1 4.6 4 1 1 5 5 2 2 Munc13 (mammalian uncoordinated) homology domain TPR_17 PF13431.6 EFC37578.1 - 0.029 14.8 16.2 43 4.8 0.0 9.2 10 0 0 10 10 8 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EFC37578.1 - 0.14 12.6 7.1 20 5.7 0.3 5.7 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation Kelch_2 PF07646.15 EFC37578.1 - 0.36 10.9 10.6 12 6.1 0.1 4.2 4 0 0 4 4 4 0 Kelch motif TPR_20 PF14561.6 EFC37578.1 - 0.39 11.1 7.4 14 6.1 0.2 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Kelch_3 PF13415.6 EFC37579.1 - 6.6e-10 39.0 0.0 5.6e-09 36.1 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC37579.1 - 2.1e-08 33.6 1.2 3.8e-08 32.8 1.2 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 EFC37579.1 - 5.5e-07 29.3 0.4 1.1e-06 28.3 0.4 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 EFC37579.1 - 3e-06 27.1 0.1 5.4e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC37579.1 - 5.3e-06 26.5 0.1 2.4e-05 24.5 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 EFC37579.1 - 5.5e-06 26.2 0.8 8.6e-06 25.6 0.8 1.5 1 1 0 1 1 1 1 Kelch motif F-box-like PF12937.7 EFC37580.1 - 0.001 18.9 0.4 0.0026 17.6 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37580.1 - 0.022 14.6 0.2 0.092 12.7 0.2 2.0 1 0 0 1 1 1 0 F-box domain ABC_tran PF00005.27 EFC37581.1 - 1.9e-30 106.2 1.7 2.4e-30 105.8 0.1 2.0 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 EFC37581.1 - 1.4e-12 48.1 8.6 1.5e-08 34.8 0.1 2.7 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC37581.1 - 2.1e-08 33.9 3.1 8.8e-07 28.6 1.0 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC37581.1 - 0.00045 19.9 0.0 0.0009 18.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 EFC37581.1 - 0.0015 18.5 0.7 0.0056 16.6 0.1 2.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_5 PF07728.14 EFC37581.1 - 0.0022 18.0 0.0 0.014 15.4 0.0 2.3 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EFC37581.1 - 0.0028 17.6 0.3 0.0079 16.1 0.2 1.9 2 0 0 2 2 2 1 RsgA GTPase NB-ARC PF00931.22 EFC37581.1 - 0.0076 15.5 0.1 0.021 14.0 0.1 1.7 1 1 0 1 1 1 1 NB-ARC domain AAA PF00004.29 EFC37581.1 - 0.01 16.3 1.7 0.082 13.3 0.2 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EFC37581.1 - 0.052 13.5 0.4 8.3 6.3 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_23 PF13476.6 EFC37581.1 - 3.7 8.0 17.5 0.082 13.4 5.3 2.8 1 1 1 2 2 2 0 AAA domain DUF4050 PF13259.6 EFC37582.1 - 5.5e-05 23.6 0.1 5.5e-05 23.6 0.1 4.2 1 1 2 3 3 3 2 Protein of unknown function (DUF4050) GPS PF01825.21 EFC37583.1 - 5.7e-09 36.4 6.1 1e-08 35.6 6.1 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF3382 PF11862.8 EFC37583.1 - 0.34 11.2 5.1 1.4 9.3 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) Med18 PF09637.10 EFC37584.1 - 0.051 13.4 0.1 0.073 12.9 0.1 1.2 1 0 0 1 1 1 0 Med18 protein HGTP_anticodon2 PF12745.7 EFC37584.1 - 0.11 12.0 1.1 0.16 11.4 1.1 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs SET PF00856.28 EFC37585.1 - 2.4e-09 37.8 16.3 4e-08 33.8 16.3 2.9 1 1 0 1 1 1 1 SET domain RGS PF00615.19 EFC37586.1 - 3.8e-08 33.6 2.7 7.4e-08 32.7 2.7 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain SIR2 PF02146.17 EFC37587.1 - 1.6e-30 106.4 1.6 1e-22 80.9 0.5 2.7 2 1 1 3 3 3 2 Sir2 family TPP_enzyme_M PF00205.22 EFC37587.1 - 0.0044 16.7 0.0 1.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain TF_Zn_Ribbon PF08271.12 EFC37587.1 - 0.64 9.6 5.3 1.4 8.5 4.2 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding Dickkopf_N PF04706.12 EFC37588.1 - 0.012 16.1 4.4 0.012 16.1 4.4 7.2 7 1 1 8 8 8 0 Dickkopf N-terminal cysteine-rich region Fibrinogen_C PF00147.18 EFC37589.1 - 9.5e-08 32.1 0.0 1.6e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 EFC37589.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain NUDE_C PF04880.13 EFC37589.1 - 0.12 12.9 1.8 0.25 11.8 1.8 1.5 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region FlaC_arch PF05377.11 EFC37589.1 - 0.29 11.5 1.4 5.5 7.5 0.3 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 EFC37589.1 - 0.41 11.0 3.9 0.98 9.8 3.9 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spexin PF15171.6 EFC37590.1 - 0.21 11.8 1.9 0.42 10.8 0.3 2.2 2 0 0 2 2 2 0 Neuropeptide secretory protein family, NPQ, spexin YppG PF14179.6 EFC37590.1 - 0.52 11.0 8.6 1 10.1 0.2 3.1 3 0 0 3 3 3 0 YppG-like protein RGS PF00615.19 EFC37591.1 - 0.00042 20.6 4.9 0.002 18.4 4.9 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain Kelch_4 PF13418.6 EFC37593.1 - 1.4e-40 137.0 12.9 1.1e-07 31.7 0.1 6.7 7 0 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC37593.1 - 1.1e-31 108.3 11.9 4e-07 29.9 0.0 6.7 7 0 0 7 7 7 6 Kelch motif Kelch_1 PF01344.25 EFC37593.1 - 9e-26 89.2 8.9 6.9e-05 22.3 0.1 6.0 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFC37593.1 - 1.9e-25 88.2 10.6 6.4e-05 23.1 0.1 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFC37593.1 - 1.2e-24 86.0 2.5 0.0012 19.0 0.0 7.1 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC37593.1 - 3.8e-22 77.4 11.5 2.8e-06 27.1 0.0 5.9 6 0 0 6 6 6 5 Kelch motif SANTA PF09133.10 EFC37593.1 - 0.075 13.5 0.2 5.5 7.5 0.0 2.9 3 0 0 3 3 3 0 SANTA (SANT Associated) TLD PF07534.16 EFC37594.1 - 2.6e-16 60.1 0.8 4.7e-16 59.3 0.8 1.4 1 0 0 1 1 1 1 TLD DNA_mis_repair PF01119.19 EFC37594.1 - 0.086 12.5 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain Peptidase_C1 PF00112.23 EFC37595.1 - 6.5e-60 202.9 4.7 8.5e-60 202.5 4.7 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC37595.1 - 5.5e-06 25.4 4.3 0.0027 16.5 0.5 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC37595.1 - 0.00052 19.8 0.0 0.0012 18.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide Ank_2 PF12796.7 EFC37596.1 - 3.7e-15 56.3 2.5 2.2e-11 44.2 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC37596.1 - 2.6e-12 47.0 0.3 9.9e-09 35.6 0.0 3.7 2 2 2 4 4 4 3 Ankyrin repeats (many copies) zf-MYND PF01753.18 EFC37596.1 - 6.2e-12 45.4 14.9 6.2e-12 45.4 14.9 3.6 3 1 0 3 3 3 1 MYND finger Ank PF00023.30 EFC37596.1 - 1.1e-11 44.6 2.0 0.09 13.3 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 EFC37596.1 - 2.6e-09 36.6 3.0 0.032 14.8 0.0 6.0 5 1 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 EFC37596.1 - 7.5e-08 32.5 0.7 0.13 12.7 0.0 5.0 2 2 2 4 4 4 2 Ankyrin repeats (many copies) F-box PF00646.33 EFC37598.1 - 0.00031 20.5 0.0 0.00045 20.0 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC37598.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 F-box-like DUF2393 PF09624.10 EFC37599.1 - 0.82 9.7 4.8 0.3 11.1 0.7 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2393) 2OG-FeII_Oxy_3 PF13640.6 EFC37600.1 - 3.9e-11 43.7 0.1 1.1e-10 42.3 0.1 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF3800 PF12686.7 EFC37600.1 - 2.5 8.7 5.4 72 4.0 5.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) F-box-like PF12937.7 EFC37601.1 - 1.2e-08 34.7 0.1 2.4e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37601.1 - 3.1e-05 23.7 0.4 0.00013 21.7 0.4 2.1 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EFC37601.1 - 0.004 17.5 36.5 0.0083 16.5 0.7 6.8 3 3 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC37601.1 - 0.092 12.8 7.8 12 6.3 0.1 4.5 3 0 0 3 3 3 0 Leucine Rich repeat DUF4522 PF15022.6 EFC37601.1 - 0.19 12.0 2.9 1.4 9.2 0.1 3.4 1 1 1 3 3 3 0 Protein of unknown function (DUF4522) PI3Ka PF00613.20 EFC37602.1 - 8.4e-13 48.1 3.4 1e-12 47.9 2.0 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EFC37602.1 - 0.03 14.2 0.2 0.074 13.0 0.0 1.7 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 Ras PF00071.22 EFC37603.1 - 6.9e-41 139.5 0.0 1.6e-40 138.3 0.0 1.7 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37603.1 - 2.7e-18 66.3 0.0 1.6e-17 63.8 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Kelch_4 PF13418.6 EFC37603.1 - 7.9e-12 45.0 1.1 8.2e-07 28.9 0.1 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC37603.1 - 2.1e-10 40.5 0.3 1.4e-08 34.7 0.0 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 EFC37603.1 - 3.7e-09 36.4 2.2 0.00026 20.9 0.3 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EFC37603.1 - 1.4e-08 34.4 0.2 3.1e-06 26.9 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 EFC37603.1 - 3.2e-07 29.8 0.5 5.5e-05 22.7 0.0 2.9 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 EFC37603.1 - 3e-05 24.2 0.1 0.0011 19.1 0.0 3.3 4 0 0 4 4 3 1 Galactose oxidase, central domain F-box PF00646.33 EFC37603.1 - 0.00066 19.5 0.7 0.002 18.0 0.7 1.8 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 EFC37603.1 - 0.019 15.5 2.3 0.48 11.0 0.6 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A vWA-TerF-like PF10138.9 EFC37603.1 - 0.09 12.9 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 vWA found in TerF C terminus Chromate_transp PF02417.15 EFC37604.1 - 5.2e-64 215.1 30.6 1e-42 145.9 6.0 2.8 3 0 0 3 3 3 2 Chromate transporter DUF808 PF05661.12 EFC37604.1 - 0.041 12.9 0.0 0.091 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF808) MOZART2 PF12926.7 EFC37604.1 - 0.073 12.7 0.1 0.25 11.0 0.1 1.9 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated CPP1-like PF11833.8 EFC37604.1 - 0.12 12.0 2.6 3.1 7.4 0.1 3.6 3 0 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like YlaC PF10777.9 EFC37604.1 - 0.16 11.8 1.7 0.4 10.5 0.0 2.3 2 0 0 2 2 2 0 Inner membrane protein YlaC PBP_N PF17093.5 EFC37604.1 - 0.2 11.9 0.0 0.54 10.5 0.0 1.6 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus PBP1_TM PF14812.6 EFC37604.1 - 0.51 10.7 9.8 6.2 7.3 0.2 3.8 4 0 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Orf78 PF06024.12 EFC37604.1 - 0.95 9.8 0.0 0.95 9.8 0.0 3.2 3 1 1 4 4 4 0 Orf78 (ac78) DUF3484 PF11983.8 EFC37604.1 - 8.2 7.6 9.4 27 6.0 5.0 2.6 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Sec63 PF02889.16 EFC37605.1 - 6e-140 464.7 12.8 5.3e-78 261.7 1.8 2.6 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 EFC37605.1 - 4.4e-49 166.6 4.0 4e-25 88.6 0.8 3.6 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 EFC37605.1 - 9.5e-28 97.3 3.5 8.8e-14 51.9 0.1 3.3 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC37605.1 - 8.8e-15 55.0 0.6 1.1e-06 28.9 0.0 5.1 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFC37605.1 - 1.1e-06 29.0 1.4 0.026 14.8 0.1 4.0 3 1 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EFC37605.1 - 6.4e-06 26.6 1.0 0.0031 17.8 0.5 3.0 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 EFC37605.1 - 1.9e-05 25.1 0.9 0.043 14.2 0.4 3.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EFC37605.1 - 0.00046 19.7 0.1 0.22 10.9 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein Helicase_PWI PF18149.1 EFC37605.1 - 0.0069 16.6 0.1 0.04 14.1 0.1 2.4 1 0 0 1 1 1 1 N-terminal helicase PWI domain Rpn9_C PF18261.1 EFC37605.1 - 0.086 12.4 1.5 0.24 11.0 1.5 1.8 1 0 0 1 1 1 0 Rpn9 C-terminal helix IstB_IS21 PF01695.17 EFC37605.1 - 0.1 12.3 0.1 5.4 6.7 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_11 PF13086.6 EFC37605.1 - 0.37 10.5 5.9 0.94 9.2 0.0 3.9 3 2 1 4 4 4 0 AAA domain LRR_6 PF13516.6 EFC37606.1 - 1.8e-06 27.5 38.9 0.13 12.4 0.0 9.1 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 EFC37606.1 - 0.00068 20.0 42.1 0.96 10.0 3.8 7.4 5 1 1 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37606.1 - 0.0038 17.6 33.0 2.2 9.2 0.3 9.4 8 1 0 8 8 8 4 Leucine Rich Repeat LRR_8 PF13855.6 EFC37606.1 - 3.8 7.4 40.4 0.12 12.2 1.9 7.5 5 2 0 6 6 6 0 Leucine rich repeat TPH PF13868.6 EFC37607.1 - 0.0032 16.1 151.5 0.0071 14.9 148.8 2.5 1 1 1 2 2 2 2 Trichohyalin-plectin-homology domain Tom6 PF17112.5 EFC37607.1 - 0.14 11.7 0.0 0.33 10.5 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom6, fungal VacA PF02691.15 EFC37607.1 - 0.15 9.9 0.1 0.23 9.3 0.1 1.1 1 0 0 1 1 1 0 Vacuolating cyotoxin Mito_carr PF00153.27 EFC37608.1 - 6.2e-08 32.5 0.2 0.026 14.4 0.1 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serpin PF00079.20 EFC37609.1 - 5.9e-87 292.4 6.0 6.6e-87 292.2 6.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_M8 PF01457.16 EFC37610.1 - 1.1e-68 232.2 6.8 1.1e-68 232.2 6.8 2.8 2 1 0 2 2 2 1 Leishmanolysin EGF_2 PF07974.13 EFC37610.1 - 1.5e-10 41.2 43.3 0.00023 21.5 6.8 4.3 3 0 0 3 3 3 3 EGF-like domain L27 PF02828.16 EFC37611.1 - 0.06 13.1 0.1 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 L27 domain LRR_6 PF13516.6 EFC37612.1 - 8.7e-05 22.3 7.5 1.8 8.8 0.2 6.1 5 0 0 5 5 5 2 Leucine Rich repeat YL1 PF05764.13 EFC37612.1 - 0.00022 21.4 14.0 0.00022 21.4 14.0 1.8 2 0 0 2 2 2 1 YL1 nuclear protein Redoxin PF08534.10 EFC37612.1 - 0.046 13.4 0.0 0.15 11.8 0.0 1.8 1 0 0 1 1 1 0 Redoxin Apt1 PF10351.9 EFC37612.1 - 0.41 9.4 23.2 0.37 9.6 9.1 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Asp-B-Hydro_N PF05279.11 EFC37612.1 - 0.84 9.7 14.2 1.9 8.5 14.2 1.5 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Phospholip_B PF04916.13 EFC37614.1 - 9.1e-100 334.7 3.1 1e-99 334.6 3.1 1.0 1 0 0 1 1 1 1 Phospholipase B Toxin_20 PF08089.11 EFC37614.1 - 0.034 14.3 0.1 0.058 13.5 0.1 1.3 1 0 0 1 1 1 0 Huwentoxin-II family Ras PF00071.22 EFC37615.1 - 5.8e-19 68.3 0.0 9e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37615.1 - 1.1e-18 67.5 0.0 2.2e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC37615.1 - 2.1e-06 27.3 0.1 3.3e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC37615.1 - 0.00013 22.0 0.0 0.00024 21.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC37615.1 - 0.0018 17.7 0.1 0.0027 17.1 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Peptidase_C2 PF00648.21 EFC37616.1 - 4.9e-48 163.7 0.0 2.5e-47 161.3 0.0 1.9 2 1 0 2 2 2 1 Calpain family cysteine protease VHL PF01847.16 EFC37616.1 - 8e-06 25.7 0.0 3.3e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 VHL beta domain F-box PF00646.33 EFC37617.1 - 0.0079 16.0 1.7 0.11 12.4 0.3 3.3 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EFC37617.1 - 0.27 11.2 1.1 1.6 8.7 0.2 2.4 2 0 0 2 2 2 0 F-box-like Paf1 PF03985.13 EFC37618.1 - 5.6e-30 104.7 14.4 5.6e-30 104.7 14.4 2.3 2 0 0 2 2 2 1 Paf1 Apt1 PF10351.9 EFC37618.1 - 1.8 7.3 25.6 0.042 12.7 14.8 2.4 2 0 0 2 2 2 0 Golgi-body localisation protein domain Cpn60_TCP1 PF00118.24 EFC37619.1 - 8.9e-149 496.2 2.8 1e-148 496.0 2.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family NHL PF01436.21 EFC37620.1 - 1.9e-55 182.2 8.5 7.6e-06 25.7 0.0 10.8 10 0 0 10 10 10 8 NHL repeat EGF_2 PF07974.13 EFC37620.1 - 2.7e-45 152.4 258.5 3.4e-06 27.3 9.2 19.1 18 1 1 19 19 19 15 EGF-like domain Arylesterase PF01731.20 EFC37620.1 - 2.4e-16 59.7 5.4 1.4 9.2 0.0 8.8 8 0 0 8 8 8 6 Arylesterase SGL PF08450.12 EFC37620.1 - 9e-16 58.2 2.4 1.5e-05 24.7 0.0 5.7 4 2 0 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EFC37620.1 - 1.1e-13 51.2 0.2 3.9 7.7 0.0 8.3 8 0 0 8 8 8 4 Strictosidine synthase EGF PF00008.27 EFC37620.1 - 0.0033 17.7 2.2 0.0033 17.7 2.2 17.9 17 0 0 17 17 17 6 EGF-like domain DUF4485 PF14846.6 EFC37620.1 - 0.18 11.9 0.2 17 5.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4485) MBG_2 PF18676.1 EFC37620.1 - 0.39 11.4 9.8 3.1 8.5 1.0 2.8 2 0 0 2 2 2 0 MBG domain (YGX type) NAGLU_N PF12971.7 EFC37620.1 - 3.1 7.7 5.0 38 4.1 0.1 4.6 4 0 0 4 4 4 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain DUF3487 PF11990.8 EFC37620.1 - 4.5 7.2 6.0 1.2 9.0 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) EGF_2 PF07974.13 EFC37621.1 - 7e-55 183.1 427.6 9.3e-05 22.7 15.0 22.4 21 1 1 22 22 22 21 EGF-like domain NHL PF01436.21 EFC37621.1 - 9.8e-12 44.3 0.0 6.9e-05 22.7 0.0 6.1 4 0 0 4 4 4 2 NHL repeat EGF PF00008.27 EFC37621.1 - 0.0059 16.9 4.3 0.0059 16.9 4.3 25.3 22 3 0 22 22 22 10 EGF-like domain Strabismus PF06638.11 EFC37622.1 - 0.063 11.9 2.2 0.093 11.4 2.2 1.2 1 0 0 1 1 1 0 Strabismus protein DUF2070 PF09843.9 EFC37622.1 - 0.9 7.7 5.7 0.16 10.2 2.4 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) IRK PF01007.20 EFC37622.1 - 1 9.2 9.8 0.73 9.6 6.9 2.0 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain ZapB PF06005.12 EFC37622.1 - 1.6 9.2 16.4 39 4.8 16.4 2.4 1 1 0 1 1 1 0 Cell division protein ZapB APG6_N PF17675.1 EFC37622.1 - 2.6 8.6 14.6 4.5 7.8 14.6 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4879 PF16219.5 EFC37624.1 - 0.016 15.4 2.1 0.35 11.1 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4879) TM_helix PF05552.12 EFC37624.1 - 0.019 15.0 2.9 0.047 13.7 2.9 1.6 1 0 0 1 1 1 0 Conserved TM helix PhoD PF09423.10 EFC37625.1 - 7.8e-12 44.9 1.0 9.7e-12 44.6 1.0 1.1 1 0 0 1 1 1 1 PhoD-like phosphatase Prefoldin PF02996.17 EFC37625.1 - 0.09 12.7 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 Prefoldin subunit Ras PF00071.22 EFC37626.1 - 4.8e-28 97.8 0.9 7.7e-28 97.1 0.9 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37626.1 - 4.2e-13 49.6 0.0 7.3e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC37626.1 - 5.1e-08 32.6 0.3 1e-07 31.6 0.2 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC37626.1 - 1.5e-07 31.2 0.1 5.2e-07 29.4 0.2 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC37626.1 - 0.00022 21.2 1.3 1.5 8.7 0.4 3.1 2 1 1 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC37626.1 - 0.0062 16.6 0.2 0.018 15.1 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EFC37626.1 - 0.018 14.0 0.7 1 8.3 0.0 2.2 1 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 EFC37626.1 - 0.032 14.5 0.3 0.27 11.5 0.3 2.2 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC37626.1 - 0.14 12.5 0.0 0.3 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain ATP_bind_1 PF03029.17 EFC37626.1 - 0.18 11.6 1.2 0.57 9.9 0.2 2.1 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein ResIII PF04851.15 EFC37626.1 - 1.3 9.0 5.3 35 4.3 0.4 3.0 1 1 1 3 3 3 0 Type III restriction enzyme, res subunit Cofilin_ADF PF00241.20 EFC37627.1 - 2.5e-23 82.2 0.5 2.8e-23 82.0 0.5 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SelP_C PF04593.14 EFC37627.1 - 0.012 15.6 0.6 0.016 15.2 0.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, C terminal region Ribosomal_L44 PF00935.19 EFC37628.1 - 4.7e-35 119.9 13.9 4.7e-35 119.9 13.9 1.6 2 0 0 2 2 2 1 Ribosomal protein L44 UDPGT PF00201.18 EFC37629.1 - 1.2e-16 60.7 0.2 2.2e-15 56.5 0.0 2.3 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFC37629.1 - 0.00011 22.2 0.0 0.0004 20.4 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain DUF5392 PF17370.2 EFC37629.1 - 0.059 13.5 1.5 0.18 11.9 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5392) bMG10 PF17973.1 EFC37630.1 - 7.8e-35 119.9 0.0 2e-34 118.6 0.0 1.8 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_BRD PF07703.14 EFC37630.1 - 3e-17 63.3 1.0 5.7e-16 59.1 0.0 3.4 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EFC37630.1 - 4.4e-16 58.5 0.0 5.3e-15 55.0 0.0 2.8 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFC37630.1 - 4.1e-15 56.0 0.0 7e-14 52.1 0.0 3.2 4 0 0 4 4 4 1 MG2 domain Big_5 PF13205.6 EFC37630.1 - 0.00021 21.9 0.1 0.00021 21.9 0.1 5.3 5 1 0 6 6 6 1 Bacterial Ig-like domain DUF11 PF01345.18 EFC37630.1 - 0.00043 20.5 0.4 0.049 13.9 0.0 3.6 3 0 0 3 3 3 1 Domain of unknown function DUF11 Big_1 PF02369.16 EFC37630.1 - 0.0086 16.1 13.6 0.092 12.8 0.2 5.8 5 1 1 6 6 6 2 Bacterial Ig-like domain (group 1) MG4 PF17789.1 EFC37630.1 - 0.06 13.5 2.8 0.55 10.4 0.1 3.9 3 0 0 3 3 3 0 Macroglobulin domain MG4 APH PF01636.23 EFC37631.1 - 3.9e-12 46.6 0.0 1.5e-11 44.7 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFC37631.1 - 0.013 14.8 0.1 0.025 13.9 0.1 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase Choline_kinase PF01633.20 EFC37631.1 - 0.028 14.0 0.1 0.056 13.0 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EFC37631.1 - 0.096 12.0 0.0 4.5 6.6 0.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family F-box-like PF12937.7 EFC37632.1 - 0.037 13.9 2.7 0.18 11.7 1.1 2.8 3 0 0 3 3 3 0 F-box-like LZ3wCH PF18517.1 EFC37633.1 - 0.41 10.8 3.0 11 6.2 0.1 2.4 2 0 0 2 2 2 0 Leucine zipper with capping helix domain V-SNARE_C PF12352.8 EFC37634.1 - 6.5e-06 26.3 0.4 1.7e-05 25.0 0.4 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Use1 PF09753.9 EFC37634.1 - 1.3e-05 25.1 3.3 3.1e-05 23.8 2.9 1.7 1 1 0 1 1 1 1 Membrane fusion protein Use1 Sec20 PF03908.13 EFC37634.1 - 0.0004 20.3 0.7 0.0023 17.8 0.0 2.3 2 1 0 2 2 2 1 Sec20 HIP1_clath_bdg PF16515.5 EFC37634.1 - 0.013 16.1 5.0 0.31 11.7 0.1 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Apolipoprotein PF01442.18 EFC37634.1 - 0.13 12.1 4.7 0.97 9.3 1.2 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain WXG100 PF06013.12 EFC37634.1 - 0.15 12.3 2.4 5.4 7.3 0.2 2.8 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Uds1 PF15456.6 EFC37634.1 - 0.25 11.5 4.8 1.7 8.8 1.9 2.5 2 0 0 2 2 2 0 Up-regulated During Septation MAS20 PF02064.15 EFC37634.1 - 0.33 11.0 7.1 0.4 10.8 4.2 2.1 2 0 0 2 2 2 0 MAS20 protein import receptor ING PF12998.7 EFC37634.1 - 0.36 11.5 6.1 3.4 8.3 1.5 2.9 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Herpes_UL25 PF01499.16 EFC37634.1 - 0.45 9.0 5.9 0.057 11.9 1.8 1.5 2 0 0 2 2 2 0 Herpesvirus UL25 family YkyA PF10368.9 EFC37634.1 - 0.68 9.6 16.6 0.63 9.7 10.3 2.2 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein DUF4551 PF15087.6 EFC37634.1 - 1.1 8.0 5.1 1.5 7.6 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF3958 PF13125.6 EFC37634.1 - 1.5 9.0 7.4 0.38 11.0 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3958) Tup_N PF08581.10 EFC37634.1 - 2.3 8.6 7.6 2.7 8.3 0.3 2.9 3 0 0 3 3 3 0 Tup N-terminal DUF745 PF05335.13 EFC37634.1 - 2.6 7.7 11.7 3.3 7.4 1.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF745) V-SNARE PF05008.15 EFC37634.1 - 3 8.3 8.4 2.9 8.3 3.7 2.7 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Lin-8 PF03353.15 EFC37634.1 - 3.2 7.2 10.5 26 4.2 10.5 2.0 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist Synaptobrevin PF00957.21 EFC37634.1 - 4.6 7.1 10.0 0.5 10.2 4.4 2.3 2 1 0 2 2 2 0 Synaptobrevin Fusion_gly PF00523.18 EFC37634.1 - 8.9 4.4 7.8 0.28 9.4 0.4 2.2 3 0 0 3 3 3 0 Fusion glycoprotein F0 Biopterin_H PF00351.21 EFC37635.1 - 8.1e-157 521.4 0.0 9.8e-157 521.2 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EFC37635.1 - 2.1e-05 24.2 0.0 4.3e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 ACT domain RCC1 PF00415.18 EFC37636.1 - 4.5e-32 110.4 0.2 9.7e-06 26.1 0.5 7.9 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37636.1 - 6.1e-24 83.2 18.1 1.2e-07 31.4 0.7 5.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat DUF5074 PF16819.5 EFC37636.1 - 8.7e-05 22.5 0.4 0.00098 19.1 0.0 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF5074) SH3_1 PF00018.28 EFC37636.1 - 0.082 12.5 0.1 0.24 11.0 0.0 1.8 2 0 0 2 2 2 0 SH3 domain Reg_prop PF07494.11 EFC37636.1 - 0.19 12.1 2.4 7 7.3 0.2 3.6 3 0 0 3 3 3 0 Two component regulator propeller Amidohydro_3 PF07969.11 EFC37637.1 - 3e-84 284.2 0.0 3.6e-84 283.9 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 EFC37637.1 - 2.4e-16 60.0 0.1 1.2e-09 38.0 0.1 3.3 3 0 0 3 3 3 3 Amidohydrolase family F-box-like PF12937.7 EFC37638.1 - 0.0024 17.7 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like FYDLN_acid PF09538.10 EFC37638.1 - 0.011 16.4 0.6 0.011 16.4 0.6 3.1 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Rota_NS26 PF01525.16 EFC37638.1 - 0.66 10.0 9.1 0.056 13.4 2.9 2.1 2 0 0 2 2 2 0 Rotavirus NS26 FAM176 PF14851.6 EFC37638.1 - 0.89 9.2 8.2 5.2 6.7 0.6 3.2 3 0 0 3 3 3 0 FAM176 family E1-E2_ATPase PF00122.20 EFC37639.1 - 3.6e-31 108.1 0.0 3.6e-31 108.1 0.0 3.6 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EFC37639.1 - 1.4e-11 45.1 0.0 0.00026 21.3 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC37639.1 - 1e-05 25.5 0.0 3.2e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) P5-ATPase PF12409.8 EFC37639.1 - 0.00035 20.7 4.0 0.00035 20.7 4.0 3.5 3 1 0 3 3 3 1 P5-type ATPase cation transporter Ifi-6-16 PF06140.13 EFC37640.1 - 5.1e-14 51.9 24.1 5.1e-14 51.9 24.1 2.2 2 0 0 2 2 2 1 Interferon-induced 6-16 family RGS PF00615.19 EFC37640.1 - 5.7e-06 26.6 0.1 1e-05 25.8 0.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PRANC PF09372.10 EFC37641.1 - 0.0013 19.0 0.3 0.016 15.5 0.0 3.1 2 0 0 2 2 2 1 PRANC domain aGPT-Pplase3 PF18746.1 EFC37641.1 - 0.058 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 SHS2_Rpb7-N PF03876.17 EFC37642.1 - 2.6e-16 59.8 0.0 4.1e-16 59.1 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 EFC37642.1 - 2.2e-07 31.1 0.0 4.6e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain ADP_ribosyl_GH PF03747.14 EFC37643.1 - 4.6e-26 92.2 0.0 2e-17 63.9 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylglycohydrolase B277 PF17623.2 EFC37643.1 - 0.048 12.7 0.8 0.1 11.7 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function RCC1 PF00415.18 EFC37644.1 - 2e-34 117.9 6.4 9.1e-07 29.4 0.0 7.7 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37644.1 - 1.1e-15 56.9 20.2 0.0002 21.0 1.1 6.2 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat PH PF00169.29 EFC37644.1 - 3.4e-11 43.6 0.4 1.6e-10 41.4 0.1 2.3 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFC37644.1 - 9.9e-05 22.5 0.0 0.00021 21.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFC37644.1 - 0.00056 20.3 2.9 0.0017 18.8 2.5 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 EFC37644.1 - 0.039 14.3 0.0 0.095 13.1 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Pkinase PF00069.25 EFC37645.1 - 6.1e-78 261.8 0.0 6.9e-78 261.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37645.1 - 1.5e-48 165.4 0.0 1.7e-48 165.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC37645.1 - 3.4e-06 26.6 0.1 6.8e-05 22.3 0.0 2.1 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EFC37645.1 - 6.5e-06 26.2 0.0 0.022 14.7 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC37645.1 - 1.1e-05 24.6 0.1 4.7e-05 22.5 0.1 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC37645.1 - 1.5e-05 23.9 0.1 6.3e-05 21.9 0.0 1.7 1 1 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 EFC37645.1 - 0.00014 21.5 0.1 0.00021 21.0 0.1 1.2 1 0 0 1 1 1 1 RIO1 family FTA2 PF13095.6 EFC37645.1 - 0.00039 20.1 0.1 0.0042 16.7 0.0 2.1 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EFC37645.1 - 0.0043 16.6 0.2 0.0068 16.0 0.2 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL COE1_HLH PF16423.5 EFC37645.1 - 0.045 13.5 0.4 0.28 10.9 0.2 2.2 2 0 0 2 2 2 0 Transcription factor COE1 helix-loop-helix domain Seadorna_VP7 PF07387.11 EFC37645.1 - 0.049 12.7 0.0 0.07 12.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 EFC37645.1 - 0.082 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MscS_porin PF12795.7 EFC37646.1 - 0.0087 15.6 4.0 0.0087 15.6 4.0 2.6 3 0 0 3 3 3 1 Mechanosensitive ion channel porin domain Mis14 PF08641.12 EFC37646.1 - 0.021 15.2 4.3 0.021 15.2 4.3 2.4 2 0 0 2 2 2 0 Kinetochore protein Mis14 like AsnC_trans_reg2 PF17805.1 EFC37646.1 - 0.058 13.6 0.1 0.47 10.6 0.0 2.5 2 0 0 2 2 2 0 AsnC-like ligand binding domain Glypican PF01153.19 EFC37646.1 - 0.35 9.6 8.2 0.055 12.3 2.3 2.0 1 1 1 2 2 2 0 Glypican TPR_MLP1_2 PF07926.12 EFC37646.1 - 0.72 9.9 14.4 3.3 7.8 0.8 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein GIDA_assoc PF13932.6 EFC37646.1 - 0.84 9.8 9.1 0.91 9.7 3.0 2.2 2 0 0 2 2 2 0 GidA associated domain Cob_adeno_trans PF01923.18 EFC37646.1 - 1.1 9.4 7.3 6.9 6.8 1.1 2.6 1 1 0 2 2 2 0 Cobalamin adenosyltransferase DUF3800 PF12686.7 EFC37646.1 - 1.1 9.9 4.0 19 5.9 4.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Gastrin PF00918.17 EFC37646.1 - 1.6 9.7 5.0 4.4 8.3 0.2 2.6 2 1 0 2 2 2 0 Gastrin/cholecystokinin family Med7 PF05983.11 EFC37646.1 - 4 7.5 9.5 16 5.5 0.6 2.3 1 1 1 2 2 2 0 MED7 protein Cauli_AT PF03233.13 EFC37646.1 - 4.4 7.2 16.7 0.57 10.1 5.1 2.5 2 0 0 2 2 2 0 Aphid transmission protein Cep57_MT_bd PF06657.13 EFC37646.1 - 9.9 6.7 10.8 9.1 6.8 0.0 3.4 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 OTCace_N PF02729.21 EFC37647.1 - 2.8e-40 137.8 0.0 4.8e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 EFC37647.1 - 1.9e-24 86.5 0.0 3.1e-24 85.8 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Lectin_C_term PF18022.1 EFC37647.1 - 0.093 13.2 0.0 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin C-terminal domain Agglutinin_C PF18021.1 EFC37647.1 - 0.1 13.1 0.0 0.54 10.8 0.0 2.0 2 0 0 2 2 2 0 Agglutinin C-terminal Metallophos PF00149.28 EFC37648.1 - 1e-40 140.4 0.1 1.3e-40 140.1 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFC37648.1 - 1.2e-19 70.5 2.2 1.5e-19 70.2 1.4 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Abhydrolase_2 PF02230.16 EFC37649.1 - 1.5e-07 31.5 0.0 0.00042 20.2 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Gram_pos_anchor PF00746.21 EFC37649.1 - 0.11 12.4 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif UQ_con PF00179.26 EFC37650.1 - 2e-28 98.8 0.3 2.3e-28 98.6 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC37650.1 - 4.7e-06 26.4 0.0 5.9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFC37650.1 - 0.005 16.7 0.2 0.0061 16.4 0.2 1.2 1 0 0 1 1 1 1 UEV domain UFC1 PF08694.11 EFC37650.1 - 0.067 12.8 0.1 0.32 10.6 0.0 2.0 1 1 2 3 3 3 0 Ubiquitin-fold modifier-conjugating enzyme 1 bVLRF1 PF18826.1 EFC37651.1 - 6.7e-32 110.4 0.0 1.1e-31 109.7 0.0 1.4 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor SLAIN PF15301.6 EFC37651.1 - 0.037 13.3 1.6 0.054 12.7 1.6 1.2 1 0 0 1 1 1 0 SLAIN motif-containing family Metallophos PF00149.28 EFC37652.1 - 5.6e-14 53.1 0.6 8.4e-14 52.5 0.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC37652.1 - 5.2e-11 43.0 0.0 1.6e-10 41.4 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_108 PF05838.12 EFC37653.1 - 7.5e-14 52.0 0.0 5.9e-13 49.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase 108 SH3_3 PF08239.11 EFC37653.1 - 5.8e-06 26.5 0.6 1e-05 25.7 0.6 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SlpA PF03217.14 EFC37653.1 - 0.0023 18.5 0.0 0.0048 17.5 0.0 1.6 1 0 0 1 1 1 1 Surface later protein A domain DUF4858 PF16150.5 EFC37653.1 - 0.082 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4858) Sugarporin_N PF11471.8 EFC37653.1 - 0.18 11.8 2.1 0.33 11.0 2.1 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension BTB PF00651.31 EFC37654.1 - 0.00013 22.1 1.5 0.00057 20.1 1.5 2.2 1 1 0 1 1 1 1 BTB/POZ domain RCC1 PF00415.18 EFC37654.1 - 0.00033 21.2 0.0 0.001 19.6 0.0 1.9 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37654.1 - 0.021 14.6 0.0 2.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37655.1 - 6.6e-06 26.6 0.3 0.57 10.8 0.0 3.7 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37655.1 - 0.0011 18.7 0.1 2.1 8.3 0.0 3.7 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat DUF4852 PF16144.5 EFC37655.1 - 1.6 8.9 5.9 0.61 10.2 1.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4852) Arf PF00025.21 EFC37656.1 - 2.4e-63 212.8 0.1 2.7e-63 212.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC37656.1 - 1.3e-13 50.9 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37656.1 - 4.9e-12 46.1 0.1 6.8e-12 45.7 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC37656.1 - 6.9e-12 45.2 1.7 1e-08 34.7 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC37656.1 - 1.5e-10 40.8 0.0 1.9e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC37656.1 - 1.2e-06 28.1 0.0 1.5e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC37656.1 - 0.00046 20.3 0.0 0.00071 19.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase TRAP-gamma PF07074.12 EFC37657.1 - 1.8e-18 66.7 6.6 3.7e-18 65.6 6.5 1.6 1 1 0 1 1 1 1 Translocon-associated protein, gamma subunit (TRAP-gamma) UPF0154 PF03672.13 EFC37657.1 - 0.023 14.7 0.0 0.046 13.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) DUF2207 PF09972.9 EFC37657.1 - 4.9 5.8 8.1 2.8 6.6 1.0 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) PDR_CDR PF06422.12 EFC37658.1 - 0.7 9.8 6.2 0.13 12.2 0.4 2.5 2 1 1 3 3 3 0 CDR ABC transporter DUF1700 PF08006.11 EFC37658.1 - 3.4 7.2 6.9 2.5 7.6 3.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Oxidored_q5_N PF01059.17 EFC37659.1 - 0.031 14.4 1.3 0.031 14.4 1.3 3.1 2 1 0 3 3 3 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus DUF3810 PF12725.7 EFC37659.1 - 0.051 12.9 4.1 0.03 13.7 1.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Orf78 PF06024.12 EFC37659.1 - 1.5 9.1 6.9 12 6.2 0.4 2.7 2 0 0 2 2 2 0 Orf78 (ac78) DHHC PF01529.20 EFC37659.1 - 7.7 6.6 12.5 11 6.1 6.8 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase Comm PF15957.5 EFC37660.1 - 0.039 14.3 1.2 2.5 8.5 0.1 2.4 2 0 0 2 2 2 0 Commissureless DUF3899 PF13038.6 EFC37660.1 - 0.1 13.1 3.1 0.42 11.1 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) F-box PF00646.33 EFC37661.1 - 0.066 13.1 0.8 1.6 8.7 0.1 3.3 3 1 0 3 3 3 0 F-box domain EGF_2 PF07974.13 EFC37665.1 - 4.3e-121 394.9 549.2 8.7e-06 26.0 4.4 37.2 36 1 1 37 37 37 36 EGF-like domain NHL PF01436.21 EFC37665.1 - 1.1e-23 82.0 14.6 1.1e-05 25.2 0.0 8.4 8 0 0 8 8 8 4 NHL repeat Arylesterase PF01731.20 EFC37665.1 - 5.2e-06 26.6 6.6 4.8 7.5 0.0 6.4 6 0 0 6 6 6 3 Arylesterase Str_synth PF03088.16 EFC37665.1 - 6.9e-05 22.9 0.0 6 7.1 0.0 4.6 4 0 0 4 4 4 2 Strictosidine synthase EGF PF00008.27 EFC37665.1 - 0.0048 17.2 2.2 0.0048 17.2 2.2 37.1 36 0 0 36 36 36 22 EGF-like domain ADP_ribosyl_GH PF03747.14 EFC37666.1 - 1.8e-47 162.5 0.0 2.4e-47 162.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase RTTN_N PF14726.6 EFC37666.1 - 0.028 15.2 0.2 0.22 12.3 0.0 2.4 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning GpcrRhopsn4 PF10192.9 EFC37666.1 - 0.065 12.6 1.1 0.083 12.3 0.0 1.7 2 0 0 2 2 2 0 Rhodopsin-like GPCR transmembrane domain CRT-like PF08627.10 EFC37667.1 - 2.8e-51 174.4 20.7 4.2e-51 173.9 20.7 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like SLC35F PF06027.12 EFC37667.1 - 1.3e-07 31.4 9.8 1.3e-07 31.4 9.8 2.1 2 0 0 2 2 2 1 Solute carrier family 35 UAA PF08449.11 EFC37667.1 - 8.6e-07 28.5 16.2 3.2e-05 23.3 8.9 2.2 1 1 0 2 2 2 2 UAA transporter family DDE_3 PF13358.6 EFC37668.1 - 0.0018 18.0 0.2 0.0035 17.1 0.2 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease zf-C2H2_12 PF18658.1 EFC37668.1 - 0.052 13.1 0.3 0.11 12.1 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger C2H2-type RGS PF00615.19 EFC37669.1 - 1.9e-08 34.6 0.0 3.3e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC37669.1 - 0.0022 17.7 0.1 0.0035 17.1 0.1 1.3 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain Mito_carr PF00153.27 EFC37670.1 - 2.4e-33 113.9 0.3 1.3e-12 47.4 0.0 3.6 2 1 1 3 3 3 3 Mitochondrial carrier protein Lys PF00062.20 EFC37670.1 - 0.029 14.6 6.5 0.047 13.9 0.0 2.7 3 1 0 3 3 3 0 C-type lysozyme/alpha-lactalbumin family dsRBD2 PF17842.1 EFC37670.1 - 0.07 13.3 1.6 0.38 10.9 0.2 2.5 3 0 0 3 3 3 0 Double-stranded RNA binding domain 2 Secretin_N_2 PF07655.13 EFC37670.1 - 0.38 11.3 17.5 0.2 12.2 7.4 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Dynamin_M PF01031.20 EFC37672.1 - 3.2e-34 118.5 9.5 6.8e-34 117.4 9.5 1.6 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 EFC37672.1 - 1.5e-29 103.3 0.3 1.5e-29 103.3 0.3 2.6 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFC37672.1 - 6.3e-08 32.7 0.2 8.5e-07 29.1 0.0 2.9 3 1 0 3 3 3 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFC37672.1 - 0.0005 20.5 0.6 0.089 13.2 0.0 3.4 3 1 0 3 3 3 1 AAA ATPase domain TniB PF05621.11 EFC37672.1 - 0.00092 18.7 0.1 0.0046 16.4 0.0 2.2 2 1 1 3 3 3 1 Bacterial TniB protein DUF3086 PF11285.8 EFC37672.1 - 0.019 14.1 0.3 0.066 12.3 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) ComGG PF14173.6 EFC37672.1 - 0.1 13.0 1.8 2.1 8.8 1.0 2.6 2 0 0 2 2 2 0 ComG operon protein 7 Toprim_Crpt PF13342.6 EFC37672.1 - 0.13 12.2 1.1 0.51 10.3 0.1 2.6 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase FliS PF02561.14 EFC37672.1 - 0.8 10.0 8.4 13 6.1 0.5 4.4 4 1 0 4 4 4 0 Flagellar protein FliS GSAP-16 PF14959.6 EFC37673.1 - 9.8e-28 96.2 3.1 3.2e-27 94.6 3.1 2.0 1 0 0 1 1 1 1 gamma-Secretase-activating protein C-term Hydrolase_4 PF12146.8 EFC37673.1 - 3.1e-06 26.6 0.0 5.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC37673.1 - 5.4e-06 27.2 0.0 8.6e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PPIP5K2_N PF18086.1 EFC37673.1 - 0.084 13.0 0.1 0.34 11.1 0.1 2.0 1 0 0 1 1 1 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain Abhydrolase_1 PF00561.20 EFC37673.1 - 0.087 12.4 0.0 0.32 10.6 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Transketolase_N PF00456.21 EFC37674.1 - 1.2e-128 428.8 0.0 1.7e-128 428.3 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EFC37674.1 - 7.3e-42 143.0 0.0 1.3e-41 142.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFC37674.1 - 3.9e-09 36.5 0.0 7.4e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EFC37674.1 - 0.0019 17.5 0.0 0.0034 16.6 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase DUF498 PF04430.14 EFC37674.1 - 0.0095 16.0 0.0 0.37 10.9 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF498/DUF598) E1_dh PF00676.20 EFC37674.1 - 0.11 11.4 0.0 0.26 10.2 0.0 1.6 2 0 0 2 2 2 0 Dehydrogenase E1 component Cyclin_N PF00134.23 EFC37675.1 - 6.2e-38 129.4 1.3 1.4e-37 128.2 0.5 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC37675.1 - 1.4e-12 47.8 0.1 1.4e-12 47.8 0.1 2.9 2 1 0 2 2 2 1 Cyclin, C-terminal domain Raptor_N PF14538.6 EFC37676.1 - 0.12 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain MR_MLE_C PF13378.6 EFC37677.1 - 9.7e-15 54.7 0.0 1.4e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 EFC37677.1 - 0.00041 20.5 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 EFC37677.1 - 0.002 17.3 0.0 0.024 13.8 0.0 2.2 2 0 0 2 2 2 1 Methylaspartate ammonia-lyase C-terminus Cyclin_N PF00134.23 EFC37678.1 - 2.8e-29 101.4 0.0 6.2e-29 100.3 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC37678.1 - 1.3e-07 31.7 6.2 1.1e-06 28.7 0.0 3.1 3 0 0 3 3 3 2 Cyclin, C-terminal domain TFIIA PF03153.13 EFC37678.1 - 0.47 10.4 18.3 0.64 9.9 18.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DFP PF04127.15 EFC37680.1 - 1.6e-36 125.9 0.0 4.7e-36 124.4 0.0 1.8 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Methyltransf_25 PF13649.6 EFC37680.1 - 1.5e-14 54.5 0.0 3.6e-14 53.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC37680.1 - 7.5e-14 51.9 0.0 1.5e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC37680.1 - 6.6e-11 42.7 0.0 1.6e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC37680.1 - 7e-10 38.9 0.2 2.3e-09 37.2 0.2 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC37680.1 - 6e-08 33.3 0.3 1.9e-07 31.7 0.1 2.1 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 EFC37680.1 - 4.8e-07 29.5 0.1 1.1e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EFC37680.1 - 7.8e-05 22.1 0.3 0.00019 20.9 0.3 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 EFC37680.1 - 0.00051 19.7 0.0 0.0016 18.1 0.0 1.8 1 0 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.14 EFC37680.1 - 0.0016 17.9 1.0 0.0037 16.7 1.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Pox_MCEL PF03291.16 EFC37680.1 - 0.014 14.5 0.7 0.044 12.9 0.7 1.7 1 1 0 1 1 1 0 mRNA capping enzyme Cons_hypoth95 PF03602.15 EFC37680.1 - 0.036 13.7 0.0 0.071 12.7 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Aldolase_II PF00596.21 EFC37680.1 - 0.067 13.1 0.0 12 5.7 0.0 2.5 1 1 1 2 2 2 0 Class II Aldolase and Adducin N-terminal domain MORN PF02493.20 EFC37681.1 - 4.6e-91 293.6 81.0 8.7e-08 31.6 0.3 15.1 15 0 0 15 15 15 15 MORN repeat DUF3048_C PF17479.2 EFC37681.1 - 0.00016 22.0 24.5 2.4 8.6 0.4 6.7 2 2 3 6 6 6 4 Protein of unknown function (DUF3048) C-terminal domain Peptidase_S55 PF05580.12 EFC37681.1 - 0.039 13.9 9.0 11 5.9 0.1 5.1 3 2 2 5 5 5 0 SpoIVB peptidase S55 DUF4926 PF16277.5 EFC37681.1 - 0.16 11.4 2.7 96 2.5 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF4926) Sar8_2 PF03058.14 EFC37681.1 - 0.18 12.3 0.1 24 5.6 0.0 2.7 3 0 0 3 3 3 0 Sar8.2 family PilJ_C PF18223.1 EFC37681.1 - 5.7 7.5 10.2 4.2 7.9 1.1 3.1 2 1 2 4 4 4 0 Pili PilJ C-terminal domain NUC205 PF08168.11 EFC37681.1 - 9.1 5.9 5.8 7 6.2 0.3 3.2 3 0 0 3 3 3 0 NUC205 domain Membr_traf_MHD PF10540.9 EFC37684.1 - 0.0066 16.6 0.1 0.0066 16.6 0.1 4.2 4 1 0 4 4 4 1 Munc13 (mammalian uncoordinated) homology domain CCDC32 PF14989.6 EFC37684.1 - 0.046 13.7 2.1 0.22 11.5 2.1 2.2 1 0 0 1 1 1 0 Coiled-coil domain containing 32 APC1_C PF18122.1 EFC37685.1 - 0.06 13.3 1.3 5 7.0 0.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex sub unit 1 C-terminal domain Zn_clus PF00172.18 EFC37686.1 - 5.6e-08 32.8 11.0 1.8e-07 31.2 11.0 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CD225 PF04505.12 EFC37686.1 - 0.033 14.3 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 Interferon-induced transmembrane protein ABC_membrane PF00664.23 EFC37687.1 - 6.6e-50 170.3 16.5 9.2e-50 169.8 16.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC37687.1 - 1.7e-35 122.5 0.0 1.2e-34 119.7 0.0 2.2 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EFC37687.1 - 9.9e-06 25.1 2.5 0.00058 19.4 0.1 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 EFC37687.1 - 0.00098 18.5 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EFC37687.1 - 0.0023 18.3 0.1 0.011 16.1 0.1 2.1 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFC37687.1 - 0.0031 17.2 0.2 0.0075 16.0 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 EFC37687.1 - 0.0066 16.2 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC37687.1 - 0.0097 16.2 0.3 0.11 12.7 0.3 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFC37687.1 - 0.037 13.8 0.0 0.1 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_ATPase PF09818.9 EFC37687.1 - 0.042 12.7 0.0 0.085 11.6 0.0 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EFC37687.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 EFC37687.1 - 0.079 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EFC37687.1 - 0.15 12.0 0.0 1 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Phage_holin_6_1 PF09682.10 EFC37687.1 - 3.1 8.3 6.5 2 8.9 3.1 2.5 2 1 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Pkinase PF00069.25 EFC37688.1 - 2.2e-65 220.6 0.2 8.1e-65 218.8 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37688.1 - 5.2e-34 117.7 0.0 9.2e-34 116.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC37688.1 - 1.4e-05 24.3 2.2 2.6e-05 23.4 2.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFC37688.1 - 0.0022 17.6 0.5 0.005 16.4 0.5 1.7 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFC37688.1 - 0.003 16.9 0.0 0.006 15.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC37688.1 - 0.0095 14.8 0.0 0.0095 14.8 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFC37688.1 - 0.018 14.4 0.1 0.035 13.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Transposase_24 PF03004.14 EFC37688.1 - 0.092 12.9 1.3 0.16 12.1 1.3 1.5 1 0 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) FTA2 PF13095.6 EFC37688.1 - 0.19 11.4 0.1 0.19 11.4 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF5094 PF17015.5 EFC37688.1 - 3 7.9 11.7 0.48 10.5 2.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) SAM_1 PF00536.30 EFC37689.1 - 2.8e-09 37.3 0.1 3.9e-09 36.8 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC37689.1 - 3.6e-06 27.0 0.1 6.8e-06 26.1 0.1 1.4 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EFC37689.1 - 0.031 14.5 0.2 0.046 14.0 0.2 1.3 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Ish1 PF10281.9 EFC37689.1 - 0.044 14.1 0.6 0.094 13.0 0.6 1.7 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Pkinase PF00069.25 EFC37690.1 - 8.2e-76 254.8 0.0 1e-75 254.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37690.1 - 9.8e-39 133.2 0.0 1.2e-38 132.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC37690.1 - 2.3e-06 27.1 0.0 1.5e-05 24.5 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EFC37690.1 - 2.8e-06 26.9 0.0 6.4e-06 25.7 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFC37690.1 - 0.00011 22.0 0.1 0.0067 16.1 0.0 2.3 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 EFC37690.1 - 0.0018 17.9 0.1 0.0037 16.9 0.1 1.4 1 0 0 1 1 1 1 RIO1 family COX_ARM PF06481.14 EFC37690.1 - 0.0068 16.3 0.0 4 7.4 0.0 2.4 2 0 0 2 2 2 2 COX Aromatic Rich Motif Pkinase_fungal PF17667.1 EFC37690.1 - 0.011 14.5 0.1 0.037 12.8 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EFC37690.1 - 0.014 15.3 0.0 0.13 12.1 0.0 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Peptidase_M1 PF01433.20 EFC37690.1 - 0.079 12.5 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Peptidase family M1 domain DUF433 PF04255.14 EFC37690.1 - 0.1 12.5 0.1 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF433) AAA_6 PF12774.7 EFC37691.1 - 4.7e-162 538.5 0.0 1.7e-159 530.1 0.0 3.4 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC37691.1 - 2.8e-119 398.8 17.6 2.8e-119 398.8 17.6 5.2 6 1 1 7 7 6 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EFC37691.1 - 2.5e-111 371.8 0.1 2.5e-111 371.8 0.1 2.4 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EFC37691.1 - 5.6e-102 340.5 1.8 3.6e-100 334.6 0.1 3.6 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFC37691.1 - 9.6e-66 221.0 7.3 9.6e-66 221.0 7.3 3.3 2 0 0 2 2 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFC37691.1 - 9.8e-66 220.7 0.0 1.4e-63 213.7 0.0 3.3 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC37691.1 - 1.6e-61 206.9 0.1 1.3e-60 203.9 0.0 2.8 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC37691.1 - 3.1e-43 146.7 0.0 1.9e-41 140.9 0.0 3.0 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 EFC37691.1 - 1.9e-38 132.4 14.6 4.8e-38 131.1 14.6 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 EFC37691.1 - 2.9e-22 79.1 2.7 9.4e-22 77.5 1.1 3.0 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFC37691.1 - 9e-20 71.1 0.0 7.2e-07 29.3 0.0 5.8 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFC37691.1 - 2.7e-16 59.6 0.3 2.1e-15 56.8 0.0 2.8 2 0 0 2 2 1 1 AAA+ lid domain RNA_helicase PF00910.22 EFC37691.1 - 2.3e-05 24.7 0.0 0.18 12.2 0.0 4.0 2 0 0 2 2 2 2 RNA helicase AAA PF00004.29 EFC37691.1 - 4.5e-05 23.9 0.4 1.3 9.5 0.0 4.5 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC37691.1 - 4.5e-05 23.7 0.0 0.14 12.5 0.0 4.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 EFC37691.1 - 0.00074 19.9 0.0 3 8.2 0.0 3.8 3 0 0 3 3 3 1 AAA ATPase domain Methyltransf_31 PF13847.6 EFC37691.1 - 0.055 13.3 0.1 0.51 10.1 0.1 2.8 1 0 0 1 1 1 0 Methyltransferase domain AAA_30 PF13604.6 EFC37691.1 - 0.12 12.1 0.3 2.9 7.6 0.1 2.9 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EFC37691.1 - 0.25 11.5 0.7 17 5.6 0.2 3.4 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 EFC37691.1 - 0.59 10.7 0.0 0.59 10.7 0.0 4.6 6 0 0 6 6 3 0 AAA domain AAA_14 PF13173.6 EFC37692.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain NFACT-R_1 PF05670.13 EFC37693.1 - 1.3e-33 115.9 0.0 4.3e-33 114.2 0.0 2.0 1 0 0 1 1 1 1 NFACT protein RNA binding domain FbpA PF05833.11 EFC37693.1 - 6.4e-32 110.9 24.5 3.6e-26 92.0 0.2 3.6 3 1 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-C PF11923.8 EFC37693.1 - 7.7e-20 70.8 0.0 7.7e-20 70.8 0.0 5.7 5 2 2 7 7 7 1 NFACT protein C-terminal domain ASL_C PF08328.11 EFC37693.1 - 0.9 9.7 8.9 0.4 10.8 0.6 3.6 2 1 0 2 2 2 0 Adenylosuccinate lyase C-terminal ParcG PF10274.9 EFC37694.1 - 1.8e-33 116.2 0.1 2.6e-33 115.7 0.1 1.2 1 0 0 1 1 1 1 Parkin co-regulated protein Pkinase PF00069.25 EFC37695.1 - 1.4e-68 231.1 0.1 2.1e-68 230.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37695.1 - 3e-39 134.9 0.0 5e-39 134.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EFC37695.1 - 4.2e-34 116.6 1.6 7.4e-16 58.1 0.1 3.0 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 EFC37695.1 - 2.2e-05 23.9 0.0 4.4e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC37695.1 - 0.00012 21.0 0.0 0.00012 21.0 0.0 2.3 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFC37695.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_9 PF14580.6 EFC37696.1 - 9.4e-17 61.1 3.1 9.4e-17 61.1 3.1 2.0 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EFC37696.1 - 3.8e-08 33.5 3.9 1.8e-07 31.3 0.9 3.2 2 1 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37696.1 - 7.6e-06 25.6 1.5 0.00015 21.4 0.9 2.3 1 1 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.6 EFC37696.1 - 0.0065 16.4 0.2 8.6 6.7 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat DUF948 PF06103.11 EFC37696.1 - 1.6 9.0 4.2 11 6.4 0.4 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Ribosomal_S20p PF01649.18 EFC37696.1 - 1.8 9.3 8.1 13 6.5 0.2 3.5 3 0 0 3 3 3 0 Ribosomal protein S20 VWA_2 PF13519.6 EFC37697.1 - 2.1e-21 76.6 0.0 1.2e-20 74.1 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 EFC37697.1 - 3.3e-05 23.8 0.0 7.2e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Ssl1-like UIM PF02809.20 EFC37697.1 - 0.0095 15.8 13.0 0.018 14.9 6.6 4.7 5 0 0 5 5 5 3 Ubiquitin interaction motif Mito_carr PF00153.27 EFC37698.1 - 9.7e-68 224.2 5.0 1.1e-25 89.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein VWA_2 PF13519.6 EFC37699.1 - 1.8e-11 44.6 0.0 4.6e-11 43.3 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFC37699.1 - 1.2e-08 35.4 0.0 1.9e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Med25_VWA PF11265.8 EFC37699.1 - 2.1e-05 24.5 0.0 4.4e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A TssR PF17643.1 EFC37699.1 - 0.00046 18.3 0.1 0.00075 17.6 0.1 1.3 1 0 0 1 1 1 1 Type VI secretion system, TssR VWA_3 PF13768.6 EFC37699.1 - 0.045 13.7 0.0 0.12 12.3 0.0 1.7 1 1 0 1 1 1 0 von Willebrand factor type A domain YtzH PF14165.6 EFC37699.1 - 0.072 13.5 1.7 0.12 12.7 0.7 1.9 2 0 0 2 2 2 0 YtzH-like protein WW PF00397.26 EFC37700.1 - 1.6e-12 47.3 5.7 1.6e-12 47.3 5.7 2.6 3 0 0 3 3 3 1 WW domain C9orf72-like PF15019.6 EFC37701.1 - 4.1e-23 82.2 8.8 1.1e-20 74.2 6.1 2.7 2 1 0 2 2 2 2 C9orf72-like protein family SelP_N PF04592.14 EFC37701.1 - 3.8 6.9 13.5 6.8 6.0 13.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Ras PF00071.22 EFC37702.1 - 8.9e-23 80.7 0.0 1.5e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC37702.1 - 2.3e-15 56.9 0.0 5e-15 55.8 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC37702.1 - 3.6e-13 49.4 0.1 6.4e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC37702.1 - 3.3e-05 23.3 0.0 5.1e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region F-box-like PF12937.7 EFC37702.1 - 3.6e-05 23.6 0.0 6.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37702.1 - 0.00028 20.7 0.0 0.00053 19.8 0.0 1.4 1 0 0 1 1 1 1 F-box domain ABC_tran PF00005.27 EFC37702.1 - 0.027 15.0 0.4 0.055 14.0 0.3 1.7 1 1 0 1 1 1 0 ABC transporter SMC_N PF02463.19 EFC37702.1 - 0.032 13.7 0.1 0.073 12.5 0.1 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF4987 PF16377.5 EFC37702.1 - 0.05 13.8 0.1 0.84 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function FTA2 PF13095.6 EFC37702.1 - 0.11 12.1 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 AAA_29 PF13555.6 EFC37702.1 - 0.11 12.2 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain LRR_4 PF12799.7 EFC37703.1 - 6.1e-10 39.2 28.8 0.068 13.6 1.9 8.0 4 2 1 7 7 7 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC37703.1 - 6.6e-06 25.8 19.2 0.055 13.6 0.0 8.3 9 0 0 9 9 9 2 Leucine Rich repeat LisH_TPL PF17814.1 EFC37703.1 - 0.0017 17.9 0.4 0.0077 15.9 0.4 2.1 1 0 0 1 1 1 1 LisH-like dimerisation domain F-box-like PF12937.7 EFC37703.1 - 0.011 15.7 0.7 0.022 14.6 0.7 1.5 1 0 0 1 1 1 0 F-box-like PRANC PF09372.10 EFC37703.1 - 0.034 14.5 0.1 0.25 11.7 0.0 2.5 2 0 0 2 2 2 0 PRANC domain LRR_8 PF13855.6 EFC37703.1 - 0.08 12.7 17.6 0.29 10.9 0.0 5.9 6 0 0 6 6 6 0 Leucine rich repeat LRR_2 PF07723.13 EFC37703.1 - 0.09 13.5 5.9 9.4 7.1 0.4 4.9 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_1 PF00560.33 EFC37703.1 - 1.8 9.4 21.0 15 6.6 0.0 7.6 8 2 0 8 8 8 0 Leucine Rich Repeat CWC25 PF12542.8 EFC37704.1 - 2e-16 60.7 0.7 2e-16 60.7 0.7 4.7 2 1 0 2 2 2 1 Pre-mRNA splicing factor adh_short PF00106.25 EFC37705.1 - 1.7e-16 60.2 0.1 3.3e-16 59.3 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC37705.1 - 1.9e-08 34.2 0.0 2.7e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC37705.1 - 0.00011 22.2 0.1 0.00023 21.1 0.0 1.5 1 1 0 1 1 1 1 KR domain Eno-Rase_NADH_b PF12242.8 EFC37705.1 - 0.007 16.1 0.0 0.11 12.2 0.0 2.5 3 0 0 3 3 3 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.21 EFC37705.1 - 0.16 11.4 0.1 0.5 9.8 0.0 1.8 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family Ldh_1_N PF00056.23 EFC37705.1 - 0.18 11.9 0.3 3.4 7.8 0.1 2.4 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain LRR_6 PF13516.6 EFC37706.1 - 2.5e-18 64.5 34.8 0.0017 18.2 0.0 10.7 11 0 0 11 11 11 6 Leucine Rich repeat RRM_1 PF00076.22 EFC37706.1 - 7.2e-08 32.1 0.1 3.7e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LRR_1 PF00560.33 EFC37706.1 - 7.7e-06 25.8 19.9 3.4 8.6 0.0 8.9 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.7 EFC37706.1 - 9.3e-06 25.9 35.9 0.032 14.7 3.8 8.0 3 2 5 8 8 8 4 Leucine Rich repeats (2 copies) RRM_Rrp7 PF17799.1 EFC37706.1 - 0.0019 18.0 0.4 0.038 13.8 0.1 2.5 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain LRR_9 PF14580.6 EFC37706.1 - 0.49 9.9 12.8 0.24 10.9 1.9 3.3 2 1 1 3 3 3 0 Leucine-rich repeat LRR_8 PF13855.6 EFC37706.1 - 0.67 9.8 36.8 2.7 7.8 1.9 9.0 8 3 0 8 8 8 0 Leucine rich repeat TPT PF03151.16 EFC37707.1 - 2.1e-27 96.2 21.6 2.8e-27 95.8 21.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC37707.1 - 8.9e-06 25.9 33.0 0.00042 20.5 11.6 3.0 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFC37707.1 - 7.8e-05 22.0 20.0 7.8e-05 22.0 20.0 2.0 1 1 0 2 2 2 1 UAA transporter family Frag1 PF10277.9 EFC37709.1 - 9.3e-09 35.1 22.1 9.3e-09 35.1 22.1 3.2 2 2 0 2 2 2 1 Frag1/DRAM/Sfk1 family zf-PARP PF00645.18 EFC37709.1 - 1.8e-06 28.7 0.9 1.8e-06 28.7 0.9 2.9 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region Abhydrolase_3 PF07859.13 EFC37709.1 - 3.1e-05 23.9 0.1 0.00034 20.5 0.1 2.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EFC37709.1 - 0.031 14.1 0.0 0.095 12.5 0.0 1.8 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFC37709.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF998 PF06197.13 EFC37709.1 - 0.18 11.4 1.6 0.23 11.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF998) Zf_RING PF16744.5 EFC37709.1 - 3.1 8.0 7.6 20 5.4 2.6 2.8 2 0 0 2 2 2 0 KIAA1045 RING finger PIP5K PF01504.18 EFC37710.1 - 2.4e-89 299.2 3.1 2.4e-89 299.2 3.1 2.7 2 2 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Rad17 PF03215.15 EFC37710.1 - 0.065 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain SNAP PF14938.6 EFC37711.1 - 0.03 13.7 4.9 0.059 12.8 4.9 1.4 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFC37711.1 - 0.046 14.0 0.2 0.093 13.0 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC37711.1 - 0.085 13.1 3.5 0.77 10.0 2.3 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Vac_Fusion PF02346.16 EFC37711.1 - 1.3 8.7 3.3 62 3.3 0.1 4.0 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 TPR_1 PF00515.28 EFC37711.1 - 2.2 8.2 4.3 0.51 10.2 0.2 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat EGF_2 PF07974.13 EFC37712.1 - 7.2e-29 99.8 170.1 0.00045 20.5 12.0 11.2 11 0 0 11 11 11 10 EGF-like domain EGF_2 PF07974.13 EFC37713.1 - 2.5e-52 174.9 280.0 1e-05 25.8 8.9 18.6 19 0 0 19 19 19 16 EGF-like domain REJ PF02010.15 EFC37713.1 - 4.8e-25 88.3 18.8 2.9e-22 79.1 16.6 2.6 2 1 0 2 2 2 2 REJ domain SPRY PF00622.28 EFC37714.1 - 6.6e-22 77.9 1.9 5.2e-06 26.6 0.0 4.5 4 0 0 4 4 4 4 SPRY domain Amino_oxidase PF01593.24 EFC37715.1 - 1.7e-26 93.6 0.0 2.4e-25 89.7 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC37715.1 - 8.3e-10 38.8 0.0 2.2e-09 37.4 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC37715.1 - 1.9e-07 31.0 0.0 8.2e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 EFC37715.1 - 0.00053 19.5 0.0 0.00075 19.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC37715.1 - 0.00063 19.1 0.0 0.033 13.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC37715.1 - 0.0023 17.1 0.0 0.0038 16.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 EFC37715.1 - 0.0071 15.1 0.0 0.074 11.7 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EFC37715.1 - 0.0099 15.2 0.2 0.89 8.7 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFC37715.1 - 0.013 14.8 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Thi4 family F420_oxidored PF03807.17 EFC37715.1 - 0.04 14.5 0.3 6.7 7.4 0.1 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_9 PF13454.6 EFC37715.1 - 0.095 12.7 0.5 2.6 8.0 0.1 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 EFC37715.1 - 0.15 12.6 0.4 1.8 9.2 0.1 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase D123 PF07065.14 EFC37716.1 - 1.2e-18 67.4 2.3 9.3e-18 64.4 0.8 2.1 2 0 0 2 2 2 1 D123 R2K_2 PF18299.1 EFC37716.1 - 0.00049 20.0 0.0 0.0051 16.7 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 2 HTH_54 PF18607.1 EFC37716.1 - 0.038 14.1 0.7 2.2 8.4 0.1 2.5 2 0 0 2 2 2 0 ParA helix turn helix domain DUF3755 PF12579.8 EFC37716.1 - 0.05 13.3 0.3 1.3 8.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3755) Ion_trans PF00520.31 EFC37717.1 - 5.3e-23 81.5 24.8 8.7e-23 80.8 24.8 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EFC37717.1 - 1.2e-09 38.0 7.8 1.2e-09 38.0 7.8 3.0 2 2 0 2 2 2 1 Ion channel Sensor PF13796.6 EFC37717.1 - 0.27 11.2 0.0 0.27 11.2 0.0 2.4 3 0 0 3 3 3 0 Putative sensor DUF4231 PF14015.6 EFC37717.1 - 2.2 8.8 4.9 0.62 10.6 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Cyclin_N PF00134.23 EFC37720.1 - 1.4e-18 66.9 0.2 1e-17 64.1 0.1 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC37720.1 - 3.5e-06 27.1 2.3 3.5e-06 27.1 2.3 2.6 2 1 1 3 3 3 1 Cyclin, C-terminal domain TUDOR PF00567.24 EFC37720.1 - 0.23 11.5 1.8 0.51 10.4 0.6 2.3 2 0 0 2 2 2 0 Tudor domain Polyketide_cyc PF03364.20 EFC37721.1 - 2.3e-05 24.6 0.0 3.5e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Med9 PF07544.13 EFC37722.1 - 0.62 10.2 8.4 2.4 8.3 2.0 2.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 NIT PF08376.10 EFC37723.1 - 6.2e-17 62.8 0.0 8.5e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Nitrate and nitrite sensing Ter PF05472.11 EFC37723.1 - 0.023 13.7 0.0 0.087 11.8 0.0 1.8 2 0 0 2 2 2 0 DNA replication terminus site-binding protein (Ter protein) TPR_1 PF00515.28 EFC37724.1 - 5.6e-49 162.0 12.6 7.9e-07 28.6 0.0 10.8 10 1 0 10 10 10 10 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37724.1 - 6.9e-43 141.3 2.9 9e-06 25.4 0.0 10.3 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFC37724.1 - 4.2e-31 104.5 14.6 0.0061 16.7 0.0 10.1 11 0 0 11 11 10 7 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37724.1 - 4.6e-21 74.9 0.1 0.001 19.3 0.0 7.5 7 2 0 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC37724.1 - 2.5e-20 71.3 2.2 0.00013 22.1 0.0 9.6 12 0 0 12 12 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37724.1 - 7.3e-19 67.1 0.2 0.16 12.7 0.0 9.6 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC37724.1 - 8.6e-19 67.5 0.0 6e-06 26.3 0.0 5.9 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37724.1 - 3.1e-17 62.9 0.0 0.002 18.7 0.0 6.6 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37724.1 - 4.6e-17 61.4 13.4 0.00011 21.8 0.0 9.9 10 3 2 12 12 11 2 TPR repeat TPR_14 PF13428.6 EFC37724.1 - 3.9e-16 58.3 0.0 0.0028 18.3 0.0 8.1 7 1 2 9 9 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC37724.1 - 1.5e-12 47.8 0.1 0.013 16.0 0.0 5.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_20 PF14561.6 EFC37724.1 - 8.3e-07 29.3 0.4 0.67 10.3 0.0 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC37724.1 - 9e-07 28.5 5.0 1.2 9.3 0.1 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC37724.1 - 1.8e-05 24.4 2.0 4.7 7.2 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat MIT PF04212.18 EFC37724.1 - 0.00013 21.9 4.9 0.78 9.9 0.1 5.3 7 0 0 7 7 5 1 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 EFC37724.1 - 0.00019 21.6 9.5 0.46 10.8 1.6 4.9 4 3 3 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 EFC37724.1 - 0.0094 15.9 1.7 0.12 12.4 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EFC37724.1 - 0.01 15.3 0.8 0.24 10.8 0.0 3.1 3 1 0 3 3 3 0 Coatomer epsilon subunit Pox_H7 PF04787.12 EFC37724.1 - 0.048 14.2 1.6 0.66 10.5 0.0 2.9 2 0 0 2 2 2 0 Late protein H7 MitMem_reg PF13012.6 EFC37724.1 - 0.066 13.6 4.3 0.45 10.9 1.3 3.3 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function BTAD PF03704.17 EFC37724.1 - 0.094 13.2 0.0 22 5.4 0.0 3.1 2 0 0 2 2 2 0 Bacterial transcriptional activator domain FliJ PF02050.16 EFC37724.1 - 0.098 12.9 1.5 0.53 10.5 0.2 2.8 3 0 0 3 3 3 0 Flagellar FliJ protein SMBP PF16785.5 EFC37724.1 - 0.39 10.9 2.3 18 5.6 0.0 3.5 4 0 0 4 4 4 0 Small metal-binding protein DUF5344 PF17279.2 EFC37724.1 - 0.52 10.9 4.0 15 6.2 0.2 4.3 3 1 1 4 4 4 0 Family of unknown function (DUF5344) RNase_T PF00929.24 EFC37725.1 - 3.4e-12 47.2 1.6 1.4e-11 45.2 1.1 2.4 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EFC37725.1 - 0.00077 19.2 0.6 0.0049 16.6 0.6 2.4 1 1 0 1 1 1 1 3'-5' exonuclease EloA-BP1 PF15870.5 EFC37725.1 - 0.009 16.3 2.4 0.009 16.3 2.4 2.7 2 0 0 2 2 2 1 ElonginA binding-protein 1 Phosphodiest PF01663.22 EFC37725.1 - 0.018 14.6 0.1 2.9 7.4 0.1 2.5 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase FAS_N PF17828.1 EFC37725.1 - 0.021 14.8 5.0 0.099 12.6 1.4 3.5 3 1 1 4 4 4 0 N-terminal domain in fatty acid synthase subunit beta DUF5051 PF16473.5 EFC37725.1 - 0.029 14.3 0.3 0.16 11.9 0.1 2.5 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like Spectrin_like PF18373.1 EFC37725.1 - 0.091 12.8 3.4 0.69 10.0 0.1 3.5 3 0 0 3 3 3 0 Spectrin like domain Tape_meas_lam_C PF09718.10 EFC37725.1 - 0.14 12.3 0.0 29 4.9 0.0 2.7 2 0 0 2 2 2 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) STAT_int PF02865.17 EFC37725.1 - 4.8 7.7 9.1 7.9 7.0 0.0 4.4 5 1 1 6 6 6 0 STAT protein, protein interaction domain Seryl_tRNA_N PF02403.22 EFC37726.1 - 6.3 7.1 12.2 11 6.3 5.1 2.8 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Sec62 PF03839.16 EFC37726.1 - 8.9 5.7 11.2 6.8 6.1 0.1 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 DUF1493 PF07377.12 EFC37726.1 - 9.9 6.7 6.8 3.9 8.0 2.5 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1493) Zip PF02535.22 EFC37727.1 - 2e-44 152.2 19.7 2.2e-42 145.5 19.7 2.1 1 1 0 1 1 1 1 ZIP Zinc transporter LRR_6 PF13516.6 EFC37728.1 - 6.3e-18 63.3 30.9 2.8e-05 23.8 0.4 10.7 13 0 0 13 13 13 5 Leucine Rich repeat LRR_8 PF13855.6 EFC37728.1 - 1.4e-16 60.0 24.7 5e-06 26.2 1.5 7.3 5 2 3 8 8 8 5 Leucine rich repeat LRR_4 PF12799.7 EFC37728.1 - 1.2e-13 51.0 43.6 1.3e-06 28.6 1.7 9.3 4 3 7 11 11 11 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37728.1 - 1.3e-08 34.2 35.8 0.18 12.5 0.6 10.3 11 0 0 11 11 11 5 Leucine Rich Repeat F-box-like PF12937.7 EFC37728.1 - 3e-08 33.4 0.2 2.7e-07 30.4 0.0 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC37728.1 - 1.5e-05 24.7 0.0 8.2e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 F-box domain DUF4957 PF16318.5 EFC37728.1 - 0.0085 16.0 1.8 0.027 14.4 1.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4957) Gpi1 PF05024.15 EFC37729.1 - 9.8e-47 159.5 14.2 1.9e-46 158.5 14.2 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Peptidase_C39 PF03412.15 EFC37729.1 - 0.027 14.3 0.1 3.3 7.5 0.1 2.5 2 0 0 2 2 2 0 Peptidase C39 family Pkinase PF00069.25 EFC37731.1 - 1.9e-56 191.4 0.1 3e-56 190.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37731.1 - 1.1e-31 110.1 0.0 2.1e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC37731.1 - 9.1e-05 21.4 0.3 0.00025 20.0 0.3 1.8 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC37731.1 - 0.00073 18.6 0.6 0.00073 18.6 0.6 2.3 2 1 1 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 EFC37731.1 - 0.053 12.8 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like GTA_TIM PF13547.6 EFC37731.1 - 0.14 11.4 1.3 0.28 10.4 1.3 1.4 1 0 0 1 1 1 0 GTA TIM-barrel-like domain Pkinase PF00069.25 EFC37732.1 - 7.9e-27 94.3 7.2 7.9e-27 94.3 7.2 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37732.1 - 1.2e-09 37.9 0.4 2.6e-09 36.8 0.4 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC37732.1 - 0.026 13.9 0.2 0.047 13.0 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NYD-SP28_assoc PF14775.6 EFC37732.1 - 0.12 12.5 2.9 0.5 10.5 1.0 3.0 3 0 0 3 3 3 0 Sperm tail C-terminal domain YabA PF06156.13 EFC37732.1 - 0.39 11.4 3.7 0.81 10.4 2.0 2.3 2 0 0 2 2 2 0 Initiation control protein YabA DUF4116 PF13475.6 EFC37733.1 - 1.7e-46 155.7 0.2 9.8e-17 60.4 0.0 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF4116) DP-EP PF08985.11 EFC37733.1 - 0.063 13.4 0.0 0.15 12.3 0.0 1.6 1 1 1 2 2 2 0 DP-EP family RNA_pol_Rpb2_45 PF10385.9 EFC37733.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.7 1 1 0 1 1 1 0 RNA polymerase beta subunit external 1 domain LRR_6 PF13516.6 EFC37734.1 - 1.5e-14 52.7 28.0 0.00016 21.5 0.0 11.1 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.7 EFC37734.1 - 1.9e-10 40.8 35.4 0.096 13.1 0.8 7.8 5 2 3 8 8 8 7 Leucine Rich repeats (2 copies) DUF4957 PF16318.5 EFC37734.1 - 0.0098 15.8 10.3 0.46 10.4 0.3 4.1 2 1 2 4 4 4 2 Domain of unknown function (DUF4957) LRR_8 PF13855.6 EFC37734.1 - 0.024 14.4 31.0 0.21 11.4 0.2 7.6 3 3 4 7 7 7 0 Leucine rich repeat LRR_1 PF00560.33 EFC37734.1 - 0.074 13.6 25.3 6.9 7.6 0.1 8.7 9 2 0 9 9 9 0 Leucine Rich Repeat E7R PF17467.2 EFC37734.1 - 5.6 7.2 9.3 6.1 7.1 0.0 3.7 4 0 0 4 4 4 0 Viral Protein E7 PIP5K PF01504.18 EFC37737.1 - 5.4e-54 183.3 7.3 1.6e-53 181.7 7.3 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase 7tm_2 PF00002.24 EFC37737.1 - 0.19 11.0 13.1 0.34 10.2 13.1 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) G8 PF10162.9 EFC37738.1 - 6.7e-18 64.9 0.0 1.4e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 EFC37738.1 - 0.18 11.7 15.4 0.58 10.0 0.6 3.8 3 0 0 3 3 3 0 Right handed beta helix region CPBP PF02517.16 EFC37740.1 - 1.1e-15 57.8 6.0 1.1e-15 57.8 6.0 3.2 2 1 1 3 3 3 1 CPBP intramembrane metalloprotease Spo7 PF03907.13 EFC37740.1 - 0.1 12.1 0.1 0.22 11.0 0.1 1.5 1 0 0 1 1 1 0 Spo7-like protein FtsX PF02687.21 EFC37740.1 - 0.11 13.0 0.1 0.11 13.0 0.1 3.9 3 1 0 3 3 3 0 FtsX-like permease family DUF1761 PF08570.10 EFC37740.1 - 0.44 10.8 11.0 0.12 12.6 3.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1761) DUF418 PF04235.12 EFC37740.1 - 3.9 7.4 9.5 1 9.3 0.1 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF418) TPR_1 PF00515.28 EFC37742.1 - 6.4e-10 38.4 0.3 4.8e-07 29.3 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37742.1 - 1.4e-08 34.2 0.1 0.00014 21.7 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC37742.1 - 5.8e-06 26.1 0.1 0.0016 18.5 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 EFC37742.1 - 0.006 17.0 0.0 0.012 16.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_19 PF14559.6 EFC37742.1 - 0.0088 16.5 0.1 0.018 15.5 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37742.1 - 0.01 15.5 0.3 4.7 7.0 0.0 2.8 2 1 0 2 2 2 0 TPR repeat PIF6 PF05341.11 EFC37742.1 - 0.11 12.6 0.2 0.27 11.4 0.2 1.6 1 0 0 1 1 1 0 Per os infectivity factor 6 SapB_1 PF05184.15 EFC37743.1 - 4e-24 84.3 15.4 5.5e-11 42.3 1.4 4.2 3 0 0 3 3 3 3 Saposin-like type B, region 1 SapB_2 PF03489.17 EFC37743.1 - 1.4e-18 66.6 19.7 1e-08 35.1 0.5 4.7 5 0 0 5 5 5 3 Saposin-like type B, region 2 DUF3507 PF12015.8 EFC37743.1 - 0.0042 16.8 0.0 0.0089 15.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Phospholip_A2_3 PF09056.11 EFC37743.1 - 0.016 15.8 0.1 1.6 9.3 0.0 2.6 3 0 0 3 3 3 0 Prokaryotic phospholipase A2 YmgD PF16456.5 EFC37743.1 - 0.018 15.1 0.2 6.1 7.0 0.0 2.7 2 0 0 2 2 2 0 YmgD protein Na_Ca_ex PF01699.24 EFC37744.1 - 4.5e-19 68.9 36.2 1.6e-11 44.4 15.9 3.7 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EFC37744.1 - 8.1e-16 58.5 16.7 8.1e-16 58.5 16.7 5.0 6 0 0 6 6 6 2 Inner membrane component domain GMC_oxred_N PF00732.19 EFC37745.1 - 1e-64 218.7 0.0 1.8e-64 218.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFC37745.1 - 4.6e-05 24.0 0.0 9.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 EFC37745.1 - 0.00024 21.3 0.1 0.0007 19.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFC37745.1 - 0.0046 16.2 0.0 0.0087 15.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC37745.1 - 0.0057 15.8 0.0 0.0085 15.2 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 EFC37745.1 - 0.034 13.4 0.0 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 EFC37745.1 - 0.046 12.8 0.0 0.93 8.5 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 EFC37745.1 - 0.065 12.9 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DAO PF01266.24 EFC37745.1 - 0.16 11.5 0.0 0.7 9.4 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase LRR_4 PF12799.7 EFC37746.1 - 1.9e-06 28.1 69.9 0.0018 18.6 8.5 10.2 2 2 10 13 13 13 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC37746.1 - 0.0039 17.1 39.4 0.012 15.6 0.0 9.9 11 0 0 11 11 11 3 Leucine Rich repeat LRR_9 PF14580.6 EFC37746.1 - 3.6 7.1 17.7 2.9 7.4 7.1 3.5 1 1 3 4 4 4 0 Leucine-rich repeat Actin PF00022.19 EFC37747.1 - 6.7e-87 291.7 0.0 5.2e-86 288.8 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC37747.1 - 0.0015 17.4 0.0 0.004 16.0 0.0 1.7 1 1 0 1 1 1 1 MreB/Mbl protein F-box-like PF12937.7 EFC37749.1 - 0.0019 18.0 0.2 0.011 15.6 0.0 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC37749.1 - 0.04 13.8 1.7 0.32 10.9 0.1 3.1 2 0 0 2 2 2 0 F-box domain MerR-DNA-bind PF09278.11 EFC37749.1 - 0.087 13.4 1.0 0.25 11.9 1.0 1.8 1 0 0 1 1 1 0 MerR, DNA binding WD40 PF00400.32 EFC37750.1 - 2.5e-06 28.1 1.5 0.027 15.3 0.1 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat F-box PF00646.33 EFC37750.1 - 4.3e-05 23.3 0.2 8.9e-05 22.3 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC37750.1 - 0.002 18.0 0.1 0.004 17.0 0.1 1.5 1 0 0 1 1 1 1 F-box-like Corazonin PF17308.2 EFC37750.1 - 0.073 13.4 0.0 0.57 10.5 0.0 2.2 2 0 0 2 2 2 0 Pro-corazonin DUF5125 PF17163.4 EFC37751.1 - 0.069 13.3 1.1 5.7 7.1 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5125) TMF_DNA_bd PF12329.8 EFC37752.1 - 0.14 12.2 2.9 0.43 10.6 2.9 1.9 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF2073 PF09846.9 EFC37753.1 - 0.1 12.4 0.1 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) DUF5526 PF17664.1 EFC37753.1 - 0.27 10.8 3.9 0.61 9.6 3.6 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5526) Peroxin-3 PF04882.12 EFC37753.1 - 0.35 9.8 5.2 2.1 7.2 0.7 2.1 2 0 0 2 2 2 0 Peroxin-3 Ku_C PF03730.14 EFC37754.1 - 1.7e-14 54.2 34.1 2.7e-10 40.8 33.2 3.3 1 1 1 2 2 2 1 Ku70/Ku80 C-terminal arm ORC6 PF05460.13 EFC37754.1 - 0.00078 18.8 12.5 0.0012 18.3 12.5 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Neur_chan_memb PF02932.16 EFC37754.1 - 0.0099 16.0 8.3 0.011 15.8 8.3 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region CDC27 PF09507.10 EFC37754.1 - 0.012 15.0 28.8 0.014 14.9 28.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 EFC37754.1 - 0.054 13.3 21.3 0.073 12.9 21.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4678 PF15727.5 EFC37754.1 - 0.072 12.4 11.5 0.099 11.9 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) SAPS PF04499.15 EFC37754.1 - 0.094 11.5 13.2 0.11 11.3 13.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2201_N PF13203.6 EFC37754.1 - 0.24 11.0 5.0 0.3 10.7 5.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Presenilin PF01080.17 EFC37754.1 - 0.38 9.5 15.6 0.46 9.2 15.6 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFC37754.1 - 0.56 9.4 12.5 0.77 8.9 12.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GAGA_bind PF06217.12 EFC37754.1 - 0.66 10.2 15.5 0.83 9.9 15.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family VIR_N PF15912.5 EFC37754.1 - 0.81 9.2 12.9 1 8.9 12.9 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Ndc1_Nup PF09531.10 EFC37754.1 - 1.2 7.8 6.9 1.2 7.7 6.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NPR3 PF03666.13 EFC37754.1 - 2 7.1 18.5 2.9 6.6 18.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5427 PF10310.9 EFC37754.1 - 3.3 6.6 20.7 4.1 6.3 20.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF908 PF06012.12 EFC37754.1 - 3.3 7.0 13.0 4.5 6.6 13.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Peroxin-3 PF04882.12 EFC37754.1 - 4.3 6.2 16.7 6.1 5.7 16.7 1.1 1 0 0 1 1 1 0 Peroxin-3 Asp-B-Hydro_N PF05279.11 EFC37754.1 - 6.4 6.8 25.0 7.9 6.5 25.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region XRN_M PF17846.1 EFC37754.1 - 9 5.1 19.7 10 4.9 19.7 1.3 1 1 0 1 1 1 0 Xrn1 helical domain Patatin PF01734.22 EFC37755.1 - 4.5e-26 92.3 1.0 3.3e-24 86.2 0.0 2.7 2 1 0 2 2 2 2 Patatin-like phospholipase XendoU PF09412.10 EFC37757.1 - 0.0067 15.7 0.4 0.017 14.3 0.4 1.6 1 0 0 1 1 1 1 Endoribonuclease XendoU CSN7a_helixI PF18392.1 EFC37758.1 - 4.6e-20 71.3 1.0 1e-19 70.2 1.0 1.6 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain PCI PF01399.27 EFC37758.1 - 3.8e-07 30.6 0.6 1.1e-06 29.1 0.4 1.8 1 1 0 1 1 1 1 PCI domain DUF4200 PF13863.6 EFC37758.1 - 0.0017 18.7 7.7 0.0035 17.7 2.9 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) Nsp1_C PF05064.13 EFC37758.1 - 0.024 14.5 1.4 0.069 13.0 1.4 1.8 1 0 0 1 1 1 0 Nsp1-like C-terminal region TetR_C_2 PF08361.11 EFC37758.1 - 0.032 14.3 0.2 5 7.2 0.0 2.4 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region DUF1154 PF06631.11 EFC37758.1 - 0.49 10.5 5.4 0.36 10.9 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) GIDA_assoc PF13932.6 EFC37758.1 - 2.3 8.3 6.3 12 6.1 1.9 2.1 1 1 1 2 2 2 0 GidA associated domain Nup54 PF13874.6 EFC37759.1 - 1.7e-39 135.1 0.8 1.7e-39 135.1 0.8 1.5 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 EFC37759.1 - 1.8e-05 24.5 0.7 1.8e-05 24.5 0.7 1.8 2 0 0 2 2 2 1 Nup54 C-terminal interacting domain Nucleoporin_FG2 PF15967.5 EFC37759.1 - 0.00014 20.6 28.0 0.00014 20.6 28.0 1.7 2 0 0 2 2 2 1 Nucleoporin FG repeated region Parvo_coat_N PF08398.10 EFC37759.1 - 0.2 11.8 0.9 0.39 10.9 0.1 1.9 2 0 0 2 2 2 0 Parvovirus coat protein VP1 Spectrin PF00435.21 EFC37759.1 - 0.41 11.2 6.0 1.9 9.0 0.1 2.8 1 1 2 3 3 3 0 Spectrin repeat APG6_N PF17675.1 EFC37759.1 - 0.67 10.5 5.7 0.62 10.6 3.4 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region FAM76 PF16046.5 EFC37759.1 - 0.86 8.9 5.8 0.059 12.7 0.4 1.7 2 0 0 2 2 2 0 FAM76 protein Syntaxin-6_N PF09177.11 EFC37759.1 - 4.6 7.9 6.3 16 6.1 1.0 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Carbpep_Y_N PF05388.11 EFC37759.1 - 9.7 6.7 7.4 18 5.9 3.6 2.9 2 1 0 2 2 2 0 Carboxypeptidase Y pro-peptide G-patch PF01585.23 EFC37761.1 - 4.3e-10 39.3 2.2 1e-09 38.1 2.2 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFC37761.1 - 0.00069 19.7 0.3 0.00069 19.7 0.3 4.1 3 1 0 3 3 3 1 G-patch domain YL1 PF05764.13 EFC37761.1 - 0.0085 16.2 50.9 0.014 15.5 50.9 1.4 1 0 0 1 1 1 1 YL1 nuclear protein Mpp10 PF04006.12 EFC37761.1 - 0.015 13.8 52.1 0.022 13.3 52.1 1.2 1 0 0 1 1 1 0 Mpp10 protein LRIF1 PF15741.5 EFC37761.1 - 1.8 7.0 36.0 2.3 6.7 36.0 1.2 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Mitofilin PF09731.9 EFC37761.1 - 2.9 6.6 40.1 4.3 6.1 40.1 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Lysine_decarbox PF03641.14 EFC37762.1 - 7.9e-08 32.5 0.0 1.5e-07 31.6 0.0 1.4 2 0 0 2 2 2 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFC37762.1 - 0.0046 16.6 0.0 0.0054 16.3 0.0 1.2 1 0 0 1 1 1 1 SLOG cluster4 family YmzC PF14157.6 EFC37762.1 - 0.091 12.9 0.1 0.2 11.8 0.1 1.7 1 1 0 1 1 1 0 YmzC-like protein DNA_ligase_A_C PF04679.15 EFC37763.1 - 6.7e-07 29.8 0.0 9.7e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region APH PF01636.23 EFC37764.1 - 1.5e-14 54.5 0.0 2.3e-14 53.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family HmuY PF14064.6 EFC37764.1 - 0.076 13.2 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 HmuY protein Acyl-CoA_dh_1 PF00441.24 EFC37765.1 - 8e-43 146.2 0.5 1.1e-42 145.8 0.5 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFC37765.1 - 1.8e-25 89.0 0.0 3e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 EFC37765.1 - 1.1e-23 84.1 0.0 2.7e-23 82.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 EFC37765.1 - 9.2e-15 55.1 0.0 1.3e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_transf_34 PF05637.12 EFC37767.1 - 3.3e-06 27.0 0.7 0.0026 17.5 0.1 2.1 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 EFC37767.1 - 0.0032 17.5 0.0 0.0051 16.8 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase MMR_HSR1 PF01926.23 EFC37768.1 - 1.1e-12 48.0 0.5 2.1e-12 47.1 0.5 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFC37768.1 - 2.6e-09 36.7 1.7 2.6e-09 36.7 1.7 1.7 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFC37768.1 - 1e-05 25.5 2.2 7.5e-05 22.7 0.3 2.5 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFC37768.1 - 1.5e-05 24.6 0.5 3.2e-05 23.5 0.5 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC37768.1 - 0.00016 21.8 1.4 0.025 14.6 0.3 2.5 1 1 1 2 2 2 1 Dynamin family Roc PF08477.13 EFC37768.1 - 0.0018 18.5 0.8 0.013 15.8 0.3 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC37768.1 - 0.0019 17.8 0.5 0.0085 15.7 0.2 2.2 2 1 0 2 2 1 1 Ras family RNA_helicase PF00910.22 EFC37768.1 - 0.0031 17.9 0.0 0.0079 16.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 EFC37768.1 - 0.0035 17.8 0.1 0.0061 17.1 0.1 1.5 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFC37768.1 - 0.0035 17.0 0.3 0.0094 15.7 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA PF00004.29 EFC37768.1 - 0.01 16.3 1.0 0.049 14.1 0.3 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Gtr1_RagA PF04670.12 EFC37768.1 - 0.013 14.9 0.2 0.033 13.5 0.1 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EFC37768.1 - 0.019 15.4 0.0 0.042 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFC37768.1 - 0.019 14.7 0.8 0.041 13.6 0.8 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC37768.1 - 0.036 14.3 0.0 0.06 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC37768.1 - 0.037 14.3 0.1 0.13 12.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 EFC37768.1 - 0.038 13.3 0.7 0.068 12.4 0.1 1.8 2 0 0 2 2 2 0 Septin DUF815 PF05673.13 EFC37768.1 - 0.043 13.0 0.1 0.043 13.0 0.1 2.2 3 1 0 3 3 3 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFC37768.1 - 0.047 13.2 0.0 0.1 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EFC37768.1 - 0.12 12.9 0.2 0.45 11.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain AIG1 PF04548.16 EFC37769.1 - 1.8e-12 47.0 0.6 3.2e-12 46.2 0.6 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 EFC37769.1 - 3.1e-12 46.6 0.4 7.8e-12 45.3 0.2 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase UBA_4 PF14555.6 EFC37769.1 - 1.3e-08 34.5 0.9 2.7e-08 33.5 0.9 1.6 1 0 0 1 1 1 1 UBA-like domain FeoB_N PF02421.18 EFC37769.1 - 2.4e-05 23.9 1.9 2.7e-05 23.7 0.2 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Ras PF00071.22 EFC37769.1 - 0.00063 19.4 1.7 0.006 16.2 1.6 2.6 1 1 0 1 1 1 1 Ras family IIGP PF05049.13 EFC37769.1 - 0.00095 18.3 2.3 0.001 18.2 0.2 2.1 3 0 0 3 3 3 1 Interferon-inducible GTPase (IIGP) Septin PF00735.18 EFC37769.1 - 0.0035 16.7 0.1 0.0078 15.5 0.1 1.7 1 0 0 1 1 1 1 Septin Dynamin_N PF00350.23 EFC37769.1 - 0.0094 16.0 8.3 0.091 12.8 0.6 3.3 3 0 0 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 EFC37769.1 - 0.024 14.5 3.7 0.11 12.4 0.4 2.6 1 1 1 2 2 2 0 RsgA GTPase Roc PF08477.13 EFC37769.1 - 0.026 14.7 3.6 0.08 13.2 0.1 2.9 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EFC37769.1 - 0.029 14.9 5.9 0.21 12.1 1.7 2.8 1 1 1 2 2 2 0 ABC transporter T2SSE PF00437.20 EFC37769.1 - 0.03 13.4 0.9 0.19 10.8 0.2 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein Arf PF00025.21 EFC37769.1 - 0.052 13.0 0.8 0.16 11.4 0.0 2.0 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA_29 PF13555.6 EFC37769.1 - 0.098 12.4 0.3 0.25 11.1 0.3 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Imm17 PF15562.6 EFC37769.1 - 0.19 11.6 0.1 0.36 10.7 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 17 SRPRB PF09439.10 EFC37769.1 - 0.24 10.8 6.8 0.2 11.1 1.1 2.9 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_8 PF12780.7 EFC37769.1 - 1.3 8.3 6.4 7.6 5.8 0.1 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region D4 AAA_23 PF13476.6 EFC37769.1 - 1.6 9.2 9.9 0.14 12.7 3.0 2.5 2 1 0 2 2 2 0 AAA domain Actin PF00022.19 EFC37770.1 - 1.3e-06 27.3 0.0 7.5e-06 24.8 0.0 1.9 2 0 0 2 2 2 1 Actin EGF_2 PF07974.13 EFC37771.1 - 2.6e-20 72.5 191.2 0.00031 21.1 6.8 13.9 13 1 1 14 14 14 11 EGF-like domain DUF4899 PF16240.5 EFC37771.1 - 0.061 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4899) LRR_6 PF13516.6 EFC37772.1 - 7.9e-33 109.7 11.2 8e-05 22.4 0.0 9.5 10 0 0 10 10 10 8 Leucine Rich repeat LRR_8 PF13855.6 EFC37772.1 - 3.2e-24 84.4 10.5 4.4e-08 32.8 0.1 4.4 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC37772.1 - 1.4e-19 69.8 10.7 0.00079 19.8 0.0 6.6 3 3 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37772.1 - 1.1e-12 46.6 2.2 1.9 9.4 0.0 8.8 10 0 0 10 10 10 2 Leucine Rich Repeat Rad1 PF02144.16 EFC37773.1 - 3.1e-40 138.0 0.5 3.9e-40 137.7 0.5 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 PCNA_C PF02747.15 EFC37773.1 - 0.011 15.9 1.8 0.057 13.6 0.0 2.4 3 0 0 3 3 3 0 Proliferating cell nuclear antigen, C-terminal domain Hus1 PF04005.12 EFC37773.1 - 0.037 13.1 0.5 0.69 9.0 0.1 2.3 2 1 0 2 2 2 0 Hus1-like protein Med21 PF11221.8 EFC37774.1 - 0.12 12.6 0.2 0.12 12.6 0.2 6.1 4 3 1 5 5 5 0 Subunit 21 of Mediator complex LemA PF04011.12 EFC37774.1 - 4.7 7.1 28.8 0.12 12.2 4.6 4.6 3 2 2 5 5 5 0 LemA family LRR_8 PF13855.6 EFC37775.1 - 1.5e-19 69.5 46.5 4.1e-08 32.9 4.7 6.3 4 2 1 5 5 5 3 Leucine rich repeat LRR_6 PF13516.6 EFC37775.1 - 2.2e-17 61.5 44.1 0.0037 17.2 0.1 12.2 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.7 EFC37775.1 - 8e-11 42.0 67.4 0.0008 19.8 0.4 8.6 2 2 7 10 10 10 9 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC37775.1 - 4.6e-08 32.8 0.3 1.9e-07 30.8 0.3 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC37775.1 - 1.9e-06 27.7 0.4 4.3e-06 26.5 0.4 1.6 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC37775.1 - 0.00018 21.6 55.5 0.29 11.8 0.6 12.2 12 1 1 13 13 13 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC37775.1 - 1.4 8.4 16.1 0.71 9.4 3.5 3.8 1 1 4 5 5 5 0 Leucine-rich repeat LRR_6 PF13516.6 EFC37776.1 - 2.2e-27 92.7 14.8 2.4e-05 24.0 0.0 8.2 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 EFC37776.1 - 5.5e-25 87.0 15.1 6.1e-05 23.3 0.1 5.4 4 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37776.1 - 3.1e-24 84.5 8.3 2.1e-09 37.0 0.6 4.2 4 0 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC37776.1 - 1.3e-08 34.2 7.2 5.1 8.0 0.1 8.1 8 2 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC37776.1 - 3.4e-06 26.7 6.9 0.0041 16.6 0.4 3.5 1 1 1 3 3 3 3 Leucine-rich repeat VirE_N PF08800.10 EFC37776.1 - 0.023 14.8 0.0 0.064 13.4 0.0 1.7 1 1 0 1 1 1 0 VirE N-terminal domain Ribosomal_L12_N PF16320.5 EFC37776.1 - 0.46 10.2 5.8 1.4 8.7 0.5 3.1 3 0 0 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain Hist_deacetyl PF00850.19 EFC37777.1 - 1.1e-78 264.8 0.1 2.2e-78 263.8 0.0 1.6 2 0 0 2 2 2 1 Histone deacetylase domain Fer4_17 PF13534.6 EFC37777.1 - 0.16 12.5 3.4 0.76 10.4 0.4 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain YkuD PF03734.14 EFC37778.1 - 0.00014 22.3 2.0 0.00075 19.9 1.9 2.0 1 1 0 1 1 1 1 L,D-transpeptidase catalytic domain C2 PF00168.30 EFC37782.1 - 1.9e-12 47.4 1.2 1.3e-11 44.7 1.2 2.3 1 1 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EFC37782.1 - 0.0073 15.9 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 CEP76 C2 domain CIA30 PF08547.12 EFC37782.1 - 0.075 13.0 1.7 5.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Complex I intermediate-associated protein 30 (CIA30) PBP1_TM PF14812.6 EFC37782.1 - 3.4 8.1 7.1 4.4 7.7 5.2 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2076 PF09849.9 EFC37782.1 - 9.4 6.2 12.9 0.076 13.1 1.7 2.8 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) NHL PF01436.21 EFC37783.1 - 3.9e-16 58.2 1.3 2.7e-05 24.0 0.0 3.9 3 0 0 3 3 3 3 NHL repeat BTB PF00651.31 EFC37783.1 - 4.4e-07 30.1 1.3 1.5e-06 28.4 0.1 2.4 3 0 0 3 3 3 1 BTB/POZ domain Phytase-like PF13449.6 EFC37783.1 - 0.00063 19.8 0.5 3 7.7 0.0 3.3 2 1 2 4 4 4 2 Esterase-like activity of phytase Linker_histone PF00538.19 EFC37783.1 - 0.0036 17.6 0.4 7.2 7.1 0.0 3.5 3 0 0 3 3 3 1 linker histone H1 and H5 family Plasmo_rep PF12135.8 EFC37783.1 - 0.022 14.3 11.3 1.5 8.4 0.4 3.8 3 0 0 3 3 3 0 Plasmodium repeat family YtzH PF14165.6 EFC37783.1 - 0.053 13.9 0.2 0.19 12.2 0.2 1.9 1 0 0 1 1 1 0 YtzH-like protein PCMT PF01135.19 EFC37783.1 - 0.055 13.2 0.4 2.1 8.0 0.0 3.1 1 1 2 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SBDS PF01172.18 EFC37783.1 - 0.13 12.3 1.3 0.59 10.3 1.3 2.2 1 1 0 1 1 1 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF4116 PF13475.6 EFC37784.1 - 2.6e-109 356.8 31.7 2e-16 59.4 0.1 9.0 5 1 2 9 9 9 9 Domain of unknown function (DUF4116) Ac81 PF05820.11 EFC37784.1 - 5e-05 23.0 1.1 0.71 9.4 0.0 3.5 2 1 1 3 3 3 2 Baculoviridae AC81 DUF1667 PF07892.11 EFC37784.1 - 0.0007 19.6 0.2 0.66 10.1 0.0 4.0 4 1 0 4 4 4 1 Protein of unknown function (DUF1667) CbiG_C PF01890.16 EFC37784.1 - 0.022 15.3 2.5 14 6.3 0.0 4.2 4 2 1 5 5 5 0 Cobalamin synthesis G C-terminus Cupredoxin_1 PF13473.6 EFC37784.1 - 0.11 12.6 1.0 25 5.1 0.0 3.5 2 1 1 3 3 3 0 Cupredoxin-like domain N6_N4_Mtase PF01555.18 EFC37784.1 - 0.91 9.2 8.1 1.8 8.2 1.3 3.4 1 1 0 2 2 2 0 DNA methylase MotCF PF09158.10 EFC37784.1 - 2.4 8.3 16.6 0.22 11.6 0.5 5.0 3 2 4 7 7 7 0 Bacteriophage T4 MotA, C-terminal RCC1 PF00415.18 EFC37785.1 - 8.5e-14 51.9 0.0 3.1e-06 27.7 0.0 2.9 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37785.1 - 8.3e-13 47.8 10.0 0.00014 21.6 1.5 5.4 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat NmrA PF05368.13 EFC37787.1 - 5.3e-14 52.3 0.0 1.3e-13 51.1 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 EFC37787.1 - 3.8e-07 29.8 0.1 5.9e-05 22.6 0.0 2.6 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC37787.1 - 6.5e-07 29.4 0.0 1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFC37787.1 - 6.8e-05 22.4 0.0 0.00017 21.1 0.0 1.6 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFC37787.1 - 0.00067 19.9 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short PF00106.25 EFC37787.1 - 0.00097 18.6 0.0 0.013 15.0 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase NAD_binding_4 PF07993.12 EFC37787.1 - 0.0085 15.3 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EFC37787.1 - 0.04 12.9 0.1 0.084 11.9 0.1 1.5 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 EFC37787.1 - 0.062 13.7 0.0 0.98 9.9 0.0 2.5 3 0 0 3 3 3 0 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 EFC37787.1 - 0.074 13.3 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain ABC1 PF03109.16 EFC37789.1 - 3.4e-31 107.9 0.1 9.1e-31 106.5 0.1 1.8 1 0 0 1 1 1 1 ABC1 family UBA PF00627.31 EFC37789.1 - 0.0067 16.3 0.3 0.86 9.6 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain AMP-binding PF00501.28 EFC37790.1 - 1.7e-48 165.3 0.0 4.9e-47 160.5 0.0 2.2 1 1 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFC37790.1 - 5.2e-20 71.7 0.0 9.8e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EFC37790.1 - 0.0059 16.9 0.0 0.017 15.5 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EFC37790.1 - 0.048 13.1 0.0 0.12 11.8 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Post_transc_reg PF13797.6 EFC37790.1 - 0.16 11.8 2.1 2.1 8.2 0.5 3.4 3 0 0 3 3 3 0 Post-transcriptional regulator EGF_2 PF07974.13 EFC37791.1 - 3.3e-07 30.5 48.5 0.0017 18.7 11.4 3.5 3 0 0 3 3 3 3 EGF-like domain Uroplakin_II PF07353.12 EFC37791.1 - 0.04 13.4 0.3 0.12 11.9 0.3 1.8 1 0 0 1 1 1 0 Uroplakin II Lipid_bd PF12888.7 EFC37792.1 - 0.064 13.7 1.6 0.11 13.0 1.6 1.4 1 0 0 1 1 1 0 Lipid-binding putative hydrolase Methyltransf_31 PF13847.6 EFC37793.1 - 1.1 9.0 3.0 1.4 8.7 0.5 2.5 3 1 0 3 3 3 0 Methyltransferase domain LRR_6 PF13516.6 EFC37794.1 - 1.9e-38 127.2 47.2 9e-06 25.3 0.2 13.6 14 0 0 14 14 14 10 Leucine Rich repeat LRR_4 PF12799.7 EFC37794.1 - 1.3e-19 69.9 50.4 0.00014 22.2 0.3 8.6 3 3 7 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37794.1 - 1.4e-19 69.6 36.4 5e-09 35.8 2.1 5.7 4 2 2 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 EFC37794.1 - 4.8e-09 36.0 16.4 6.2e-05 22.6 3.6 3.6 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EFC37794.1 - 0.53 11.0 38.4 12 7.0 0.0 10.6 11 2 1 12 12 12 0 Leucine Rich Repeat REJ PF02010.15 EFC37796.1 - 1.5e-34 119.6 6.4 1.5e-34 119.6 6.4 2.8 2 1 0 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC37796.1 - 3.4e-08 33.7 137.8 0.00028 21.2 13.3 11.1 10 1 1 11 11 11 6 EGF-like domain Laminin_EGF PF00053.24 EFC37796.1 - 4.6e-07 29.9 110.5 0.00096 19.2 11.9 7.2 2 2 4 6 6 6 4 Laminin EGF domain Big_3_3 PF13750.6 EFC37796.1 - 0.0025 17.5 0.2 0.0025 17.5 0.2 2.8 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 3) TMEM154 PF15102.6 EFC37796.1 - 0.0046 16.9 2.4 0.0046 16.9 2.4 2.8 2 1 0 2 2 2 1 TMEM154 protein family RRM_1 PF00076.22 EFC37797.1 - 1.6e-20 72.7 6.4 4.6e-06 26.4 0.0 5.7 6 0 0 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC37797.1 - 2.3e-17 62.7 3.7 2.1e-07 30.6 0.2 4.0 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 EFC37797.1 - 0.13 12.5 1.0 6.8 7.0 0.1 3.2 3 0 0 3 3 3 0 BRCA1-associated protein 2 Oxidored_FMN PF00724.20 EFC37799.1 - 2e-76 257.5 0.0 2.5e-76 257.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFC37799.1 - 0.0092 15.1 0.1 0.38 9.8 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) RGS PF00615.19 EFC37800.1 - 1.3e-06 28.6 1.5 3.5e-06 27.3 1.5 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain NdhL PF10716.9 EFC37800.1 - 0.15 12.0 0.1 0.15 12.0 0.1 3.8 2 1 2 4 4 4 0 NADH dehydrogenase transmembrane subunit F-box_4 PF15966.5 EFC37802.1 - 0.00014 21.7 0.3 0.00033 20.5 0.3 1.6 1 0 0 1 1 1 1 F-box F-box PF00646.33 EFC37802.1 - 0.0037 17.1 1.1 0.011 15.6 0.2 2.2 2 0 0 2 2 2 1 F-box domain Ank_2 PF12796.7 EFC37802.1 - 0.011 16.3 0.0 0.033 14.8 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC37802.1 - 0.035 14.7 0.0 14 6.4 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) RGS PF00615.19 EFC37803.1 - 9.7e-09 35.5 0.2 1.7e-08 34.8 0.2 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4282 PF14110.6 EFC37803.1 - 0.0059 17.3 5.5 0.0059 17.3 5.5 3.7 3 1 0 3 3 3 1 Domain of unknown function (DUF4282) Phasin_2 PF09361.10 EFC37803.1 - 0.068 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Phasin protein HXXEE PF13787.6 EFC37803.1 - 7 7.5 21.6 0.043 14.6 3.3 3.4 2 1 1 3 3 3 0 Protein of unknown function with HXXEE motif Actin PF00022.19 EFC37804.1 - 6.2e-73 245.7 0.0 7.5e-73 245.5 0.0 1.0 1 0 0 1 1 1 1 Actin Nefa_Nip30_N PF10187.9 EFC37805.1 - 5.9e-14 52.3 13.8 5.9e-14 52.3 13.8 2.6 2 1 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Abhydrolase_2 PF02230.16 EFC37805.1 - 1.1 9.0 3.6 0.38 10.5 0.2 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Nefa_Nip30_N PF10187.9 EFC37807.1 - 6e-14 52.3 13.8 6e-14 52.3 13.8 2.6 2 1 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Abhydrolase_2 PF02230.16 EFC37807.1 - 1 9.1 3.6 0.37 10.6 0.2 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase RCC1 PF00415.18 EFC37809.1 - 2.3e-23 82.6 3.7 6.6e-07 29.9 0.0 6.8 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37809.1 - 8.1e-20 70.1 8.8 5.1e-07 29.3 0.0 7.1 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Kelch_6 PF13964.6 EFC37809.1 - 0.025 14.8 0.1 0.22 11.9 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Pkinase PF00069.25 EFC37810.1 - 1.9e-49 168.4 0.1 3.9e-49 167.4 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37810.1 - 6.3e-21 74.8 0.0 1.5e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EFC37810.1 - 0.00021 20.9 1.8 0.0004 20.0 0.6 2.2 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 EFC37810.1 - 0.0052 16.7 0.0 0.0085 16.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Metallophos PF00149.28 EFC37811.1 - 2.5e-13 51.0 3.5 4.2e-13 50.3 3.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC37811.1 - 0.00022 21.5 3.9 0.00063 20.0 3.9 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Fer2 PF00111.27 EFC37812.1 - 3.8e-06 26.8 1.5 5e-06 26.4 1.5 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Proteasome_A_N PF10584.9 EFC37812.1 - 0.063 13.0 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 Proteasome subunit A N-terminal signature RRM_1 PF00076.22 EFC37813.1 - 1.7e-18 66.2 0.0 3.2e-18 65.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRPL52 PF18699.1 EFC37814.1 - 6.6e-12 45.5 0.0 8.9e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Mitoribosomal protein mL52 Ldh_1_N PF00056.23 EFC37815.1 - 9e-32 110.1 0.2 1.4e-31 109.5 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EFC37815.1 - 1.1e-31 110.0 0.0 1.6e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain KfrB PF18790.1 EFC37815.1 - 0.05 13.8 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 KfrB protein Sel1 PF08238.12 EFC37816.1 - 9.9e-44 146.8 14.9 1.1e-11 45.0 0.0 8.4 8 0 0 8 8 8 8 Sel1 repeat TPR_2 PF07719.17 EFC37816.1 - 2.2e-07 30.4 14.6 0.14 12.4 1.7 7.0 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC37816.1 - 2.3e-05 24.5 4.2 0.0017 18.5 0.6 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFC37816.1 - 6.3e-05 22.9 19.4 0.028 14.6 0.1 6.2 6 2 0 6 6 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC37816.1 - 8e-05 23.2 0.4 0.64 10.7 0.2 3.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC37816.1 - 0.001 18.8 15.2 0.53 10.2 0.0 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37816.1 - 0.0017 18.6 5.4 0.54 10.6 0.1 5.1 3 2 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37816.1 - 0.0082 16.7 3.3 11 6.9 0.6 4.5 6 0 0 6 6 6 1 Tetratricopeptide repeat RPN7 PF10602.9 EFC37816.1 - 0.01 15.6 0.0 0.12 12.1 0.0 2.3 1 1 0 1 1 1 0 26S proteasome subunit RPN7 DUF992 PF06186.11 EFC37816.1 - 0.097 12.5 0.1 3.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF992) TPR_11 PF13414.6 EFC37816.1 - 1.2 8.9 10.4 3.5 7.4 0.0 4.6 5 0 0 5 5 5 0 TPR repeat DUF563 PF04577.14 EFC37817.1 - 0.00042 20.5 0.0 0.00088 19.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Tubulin PF00091.25 EFC37818.1 - 3.5e-53 180.7 0.4 5.7e-53 180.0 0.4 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC37818.1 - 5.1e-27 94.5 0.0 1.1e-26 93.4 0.0 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC37818.1 - 0.0025 17.5 0.0 0.01 15.6 0.0 1.9 2 0 0 2 2 2 1 Tubulin domain DUF2719 PF10891.8 EFC37818.1 - 0.0077 16.1 0.3 0.051 13.5 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF2719) E1-E2_ATPase PF00122.20 EFC37819.1 - 1.5e-08 34.3 0.2 1.5e-08 34.3 0.2 4.6 5 1 1 6 6 6 2 E1-E2 ATPase Hydrolase_3 PF08282.12 EFC37819.1 - 1.8e-08 34.5 0.0 0.0014 18.5 0.0 2.8 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFC37819.1 - 8.8e-05 22.9 0.0 0.89 9.8 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase DUF4512 PF14975.6 EFC37819.1 - 0.19 12.5 0.3 0.63 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Ribosomal_L31e PF01198.19 EFC37820.1 - 4.3e-19 68.5 0.2 6.1e-19 68.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e DNA_pol_A_exo1 PF01612.20 EFC37821.1 - 1.4e-10 41.1 0.2 2.7e-07 30.5 0.1 3.2 2 1 0 2 2 2 1 3'-5' exonuclease Leptin PF02024.15 EFC37821.1 - 0.025 14.4 0.1 0.061 13.1 0.1 1.6 1 0 0 1 1 1 0 Leptin MscS_porin PF12795.7 EFC37821.1 - 0.042 13.4 1.3 0.08 12.5 1.3 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF1366 PF07104.11 EFC37821.1 - 0.6 9.8 4.3 0.37 10.5 0.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1366) APG6_N PF17675.1 EFC37821.1 - 3.1 8.3 9.2 0.25 11.9 3.8 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region Prefoldin_2 PF01920.20 EFC37821.1 - 7.5 6.6 9.4 0.61 10.1 0.8 3.0 3 0 0 3 3 3 0 Prefoldin subunit Mannosyl_trans3 PF11051.8 EFC37822.1 - 0.068 12.5 0.7 0.088 12.1 0.7 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative LRR_4 PF12799.7 EFC37823.1 - 4.1e-15 55.6 35.7 0.00035 20.9 4.7 6.7 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37823.1 - 5.1e-09 35.8 26.9 1.2e-05 25.0 4.1 6.1 2 2 6 8 8 8 6 Leucine rich repeat F-box-like PF12937.7 EFC37823.1 - 0.00024 20.9 0.1 0.00072 19.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC37823.1 - 0.00036 20.3 0.5 0.0013 18.5 0.0 2.3 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 EFC37823.1 - 0.0007 19.5 16.8 0.25 11.5 0.0 6.5 6 1 1 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 EFC37823.1 - 0.087 13.4 20.1 4.8 8.1 0.5 6.8 6 1 0 6 6 6 0 Leucine Rich Repeat RecO_N_2 PF13114.6 EFC37823.1 - 0.14 11.9 1.6 19 5.0 0.1 3.8 4 1 0 4 4 4 0 RecO N terminal DUF4116 PF13475.6 EFC37824.1 - 1.9e-73 242.0 15.3 1.1e-17 63.5 0.0 8.4 6 2 2 8 8 8 7 Domain of unknown function (DUF4116) BsuBI_PstI_RE PF06616.11 EFC37824.1 - 0.048 12.9 0.3 19 4.5 0.0 3.0 3 0 0 3 3 3 0 BsuBI/PstI restriction endonuclease domain MMR_HSR1 PF01926.23 EFC37825.1 - 2.3e-06 27.7 1.2 3.8e-06 26.9 0.2 1.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFC37825.1 - 9.7e-06 25.1 0.5 1.9e-05 24.1 0.5 1.5 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 EFC37825.1 - 0.00012 22.3 0.1 0.00051 20.2 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 EFC37825.1 - 0.00041 20.1 0.1 0.0041 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain Arf PF00025.21 EFC37825.1 - 0.0015 18.1 0.2 0.0047 16.4 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_22 PF13401.6 EFC37825.1 - 0.0023 18.2 0.0 0.0057 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFC37825.1 - 0.0023 18.4 1.5 0.0034 17.9 0.9 1.9 1 1 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 EFC37825.1 - 0.0038 17.3 0.0 0.0078 16.3 0.0 1.7 1 0 0 1 1 1 1 Dynamin family SRPRB PF09439.10 EFC37825.1 - 0.0049 16.3 0.0 0.016 14.6 0.0 1.9 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 EFC37825.1 - 0.0052 16.5 0.2 0.052 13.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC37825.1 - 0.0065 16.4 0.4 0.062 13.2 0.0 2.4 3 0 0 3 3 3 1 RsgA GTPase DUF758 PF05527.11 EFC37825.1 - 0.0074 16.3 0.7 0.26 11.3 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF758) G-alpha PF00503.20 EFC37825.1 - 0.0084 15.3 1.7 0.012 14.8 0.4 2.1 1 1 0 2 2 2 1 G-protein alpha subunit AAA_28 PF13521.6 EFC37825.1 - 0.0085 16.4 0.1 0.015 15.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC37825.1 - 0.0095 16.5 0.0 0.02 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFC37825.1 - 0.016 14.8 0.0 0.041 13.4 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EFC37825.1 - 0.018 14.8 0.5 4.3 7.0 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ras PF00071.22 EFC37825.1 - 0.023 14.3 3.7 0.18 11.4 0.8 2.9 1 1 1 2 2 2 0 Ras family cobW PF02492.19 EFC37825.1 - 0.024 14.2 0.3 0.081 12.5 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EFC37825.1 - 0.026 14.9 0.0 0.062 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 EFC37825.1 - 0.06 13.4 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFC37825.1 - 0.088 12.6 0.0 0.34 10.6 0.0 2.0 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 EFC37825.1 - 0.095 12.0 0.3 0.22 10.9 0.1 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_33 PF13671.6 EFC37825.1 - 0.11 12.6 0.1 0.74 10.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 EFC37825.1 - 0.17 10.9 0.2 0.27 10.3 0.2 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 EFC37825.1 - 0.75 10.3 6.2 3.2 8.2 6.2 2.2 1 1 0 1 1 1 0 AAA domain RNase_H PF00075.24 EFC37826.1 - 1.7e-17 63.9 1.7 4.6e-17 62.5 1.7 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EFC37826.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase-like Adeno_GP19K PF04881.13 EFC37826.1 - 0.012 15.6 0.1 0.027 14.5 0.1 1.5 1 0 0 1 1 1 0 Adenovirus GP19K zf-RVT PF13966.6 EFC37826.1 - 0.05 14.3 4.1 0.074 13.8 1.6 2.7 2 1 0 2 2 2 0 zinc-binding in reverse transcriptase dCMP_cyt_deam_1 PF00383.23 EFC37826.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DSPc PF00782.20 EFC37827.1 - 2.8e-08 33.6 0.0 4.2e-08 33.1 0.0 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC37827.1 - 4e-06 26.6 0.0 5.3e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFC37827.1 - 0.013 15.6 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Actin PF00022.19 EFC37829.1 - 7.5e-148 492.5 0.0 3e-147 490.5 0.0 1.7 1 1 0 1 1 1 1 Actin Methyltransf_29 PF03141.16 EFC37829.1 - 0.14 10.6 0.0 0.33 9.4 0.0 1.6 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase REJ PF02010.15 EFC37830.1 - 8.6e-17 61.1 6.0 8.6e-17 61.1 6.0 4.1 2 2 2 4 4 4 1 REJ domain EGF_2 PF07974.13 EFC37830.1 - 2.6e-16 59.7 74.2 0.00023 21.5 10.0 5.9 5 0 0 5 5 5 5 EGF-like domain TMEM132D_C PF15706.5 EFC37830.1 - 0.094 12.5 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Laminin_G_3 PF13385.6 EFC37832.1 - 1.9e-16 60.6 2.1 3.7e-16 59.6 0.4 2.5 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Ephrin_rec_like PF07699.13 EFC37832.1 - 1.1e-07 31.5 4.5 1.1e-07 31.5 4.5 4.2 2 1 1 3 3 3 2 Putative ephrin-receptor like Pentaxin PF00354.17 EFC37832.1 - 2.4e-05 24.1 0.0 7.6e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Pentaxin family OSTbeta PF15048.6 EFC37832.1 - 0.028 14.6 0.1 0.082 13.1 0.1 1.8 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein TIG_2 PF18020.1 EFC37832.1 - 0.066 13.8 0.7 70 4.1 0.0 5.2 4 0 0 4 4 4 0 TIG domain found in plexin Pox_A14 PF05767.12 EFC37832.1 - 0.17 12.0 0.0 0.17 12.0 0.0 3.7 4 0 0 4 4 4 0 Poxvirus virion envelope protein A14 SAM_2 PF07647.17 EFC37834.1 - 0.0058 16.7 0.5 4.9 7.3 0.0 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Chordopox_A15 PF05846.12 EFC37834.1 - 0.079 13.2 0.8 2.6 8.3 0.1 2.9 2 0 0 2 2 2 0 Chordopoxvirus A15 protein Dynamin_M PF01031.20 EFC37834.1 - 0.18 11.0 2.6 0.15 11.2 0.3 2.0 2 0 0 2 2 2 0 Dynamin central region PEMT PF04191.13 EFC37835.1 - 1.4e-15 57.5 1.8 1.4e-15 57.5 1.8 1.7 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 EFC37835.1 - 3.3e-09 37.0 0.7 4.4e-09 36.6 0.1 1.6 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ERG4_ERG24 PF01222.17 EFC37835.1 - 0.0015 17.4 0.7 0.0018 17.1 0.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFC37835.1 - 0.0039 16.7 0.6 0.0047 16.5 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 EFC37835.1 - 0.0043 16.6 0.1 0.0051 16.3 0.1 1.3 1 1 0 1 1 1 1 NnrU protein Rootletin PF15035.6 EFC37836.1 - 0.051 13.6 3.6 0.11 12.6 3.6 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Pim PF16765.5 EFC37838.1 - 3.4 7.9 7.9 0.78 9.9 3.0 2.5 2 0 0 2 2 2 0 Pesticin immunity protein DUF4116 PF13475.6 EFC37839.1 - 1.4e-139 453.7 18.4 4e-13 48.9 0.0 12.2 4 3 12 16 16 16 16 Domain of unknown function (DUF4116) CwsA PF10814.8 EFC37839.1 - 0.11 12.6 1.1 1.1 9.4 0.1 3.1 4 0 0 4 4 4 0 Cell wall synthesis protein CwsA PreAtp-grasp PF18604.1 EFC37839.1 - 0.17 11.5 0.1 60 3.3 0.0 4.1 5 0 0 5 5 5 0 Pre ATP-grasp domain DUF1154 PF06631.11 EFC37839.1 - 0.44 10.6 1.8 0.83 9.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) CBFD_NFYB_HMF PF00808.23 EFC37840.1 - 4.1e-11 43.0 0.1 6.9e-11 42.3 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFC37840.1 - 0.00024 21.4 2.9 0.00024 21.4 2.9 2.6 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 DUF4719 PF15843.5 EFC37840.1 - 0.055 13.6 1.8 0.083 13.0 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) DUF5427 PF10310.9 EFC37840.1 - 3 6.7 9.1 0.075 12.0 1.9 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5427) MBOAT PF03062.19 EFC37843.1 - 6.2e-26 91.6 15.4 6.2e-26 91.6 15.4 2.4 1 1 1 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family YjeF_N PF03853.15 EFC37844.1 - 5.4e-34 117.5 0.0 6.4e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus NHL PF01436.21 EFC37845.1 - 2.2e-22 77.9 17.1 1.6e-05 24.7 0.0 6.1 6 0 0 6 6 6 5 NHL repeat PQQ PF01011.21 EFC37845.1 - 0.0071 16.2 0.1 3.5 7.7 0.1 3.2 3 0 0 3 3 3 2 PQQ enzyme repeat DUF5128 PF17170.4 EFC37845.1 - 0.017 14.3 0.4 1.2 8.3 0.0 2.4 2 0 0 2 2 2 0 6-bladed beta-propeller Shugoshin_N PF07558.11 EFC37845.1 - 0.05 13.5 0.3 0.13 12.2 0.3 1.7 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Lactonase PF10282.9 EFC37845.1 - 0.099 11.9 0.1 0.68 9.1 0.1 2.3 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller BmKX PF09132.10 EFC37845.1 - 0.23 11.5 1.1 0.47 10.5 1.1 1.5 1 0 0 1 1 1 0 BmKX SOG2 PF10428.9 EFC37846.1 - 1.5 7.9 26.0 2.6 7.1 26.0 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Hid1 PF12722.7 EFC37846.1 - 3 5.9 16.9 5.2 5.1 16.9 1.5 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4611 PF15387.6 EFC37847.1 - 3.7 7.8 6.8 20 5.4 4.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 EFC37847.1 - 7.8 7.0 14.0 43 4.6 10.1 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain LRR_6 PF13516.6 EFC37848.1 - 1.6e-19 68.2 10.5 5.6e-05 22.9 0.0 6.2 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 EFC37848.1 - 5.9e-16 58.0 7.6 6.8e-07 29.0 1.0 3.8 2 2 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC37848.1 - 1.2e-10 41.5 12.5 0.00046 20.5 1.0 4.6 2 2 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37848.1 - 2.5e-09 36.4 1.8 0.71 10.6 0.1 6.4 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC37848.1 - 0.00032 20.2 3.0 0.0043 16.6 0.1 2.2 1 1 1 2 2 2 2 Leucine-rich repeat F-box-like PF12937.7 EFC37848.1 - 0.034 14.1 0.3 0.067 13.1 0.3 1.5 1 0 0 1 1 1 0 F-box-like DUF1647 PF07801.11 EFC37848.1 - 0.054 13.2 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) HU-CCDC81_euk_2 PF18289.1 EFC37848.1 - 0.099 12.8 0.3 0.21 11.8 0.3 1.5 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 F-box PF00646.33 EFC37848.1 - 0.12 12.3 1.7 0.36 10.8 1.7 1.9 1 1 0 1 1 1 0 F-box domain RCC1_2 PF13540.6 EFC37850.1 - 1.5e-19 69.3 31.1 0.0011 18.7 0.0 9.9 10 0 0 10 10 10 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37850.1 - 1.2e-16 61.1 29.6 1.6e-07 31.8 0.0 9.7 10 0 0 10 10 10 4 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC37850.1 - 3.4e-06 27.3 5.4 9.2e-06 25.9 5.4 1.7 1 0 0 1 1 1 1 EGF-like domain EGF_Tenascin PF18720.1 EFC37850.1 - 0.002 18.1 3.5 0.0056 16.7 3.5 1.8 1 0 0 1 1 1 1 Tenascin EGF domain EGF PF00008.27 EFC37850.1 - 0.11 12.9 2.2 0.31 11.4 2.2 1.8 1 0 0 1 1 1 0 EGF-like domain HSA PF07529.13 EFC37852.1 - 0.037 14.3 0.1 0.21 11.9 0.1 2.1 1 1 0 1 1 1 0 HSA DUF676 PF05057.14 EFC37854.1 - 8.4e-22 77.8 1.3 2.4e-21 76.2 1.3 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EFC37854.1 - 1.3e-05 25.2 0.0 3.6e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Nodulin PF02451.15 EFC37854.1 - 0.001 18.6 0.2 0.045 13.2 0.0 2.4 2 0 0 2 2 2 1 Nodulin DUF3657 PF12394.8 EFC37854.1 - 0.0012 19.3 0.3 0.011 16.3 0.3 2.8 1 1 0 1 1 1 1 Protein FAM135 PGAP1 PF07819.13 EFC37854.1 - 0.0023 17.7 0.0 0.0048 16.6 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein D123 PF07065.14 EFC37855.1 - 1.3e-12 47.5 1.2 3.1e-12 46.3 1.1 1.7 1 1 0 1 1 1 1 D123 E1_UFD PF09358.10 EFC37855.1 - 0.00086 20.0 2.8 0.002 18.8 0.7 2.5 2 0 0 2 2 2 1 Ubiquitin fold domain HATPase_c PF02518.26 EFC37856.1 - 2e-22 79.8 0.1 5.4e-22 78.4 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC37856.1 - 5.7e-15 55.5 0.1 1.3e-14 54.3 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC37856.1 - 3.1e-08 33.5 0.1 7.9e-08 32.2 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain DUF2207 PF09972.9 EFC37857.1 - 0.0038 16.1 0.1 0.0039 16.0 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Jiraiya PF15038.6 EFC37857.1 - 1.4 8.3 8.2 3.1 7.2 8.3 1.4 1 1 0 1 1 1 0 Jiraiya zf-RING_UBOX PF13445.6 EFC37858.1 - 0.00033 20.6 9.6 0.0024 17.8 9.6 2.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC37858.1 - 0.0014 18.4 11.6 0.0014 18.4 11.6 2.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC37858.1 - 0.0019 18.1 10.6 0.0019 18.1 10.6 2.8 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFC37858.1 - 0.0028 17.5 7.9 0.0028 17.5 7.9 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC37858.1 - 0.0052 17.1 11.3 0.0052 17.1 11.3 2.3 2 0 0 2 2 2 1 Ring finger domain zf-TRAF PF02176.18 EFC37858.1 - 0.01 16.5 0.7 0.01 16.5 0.7 2.1 2 0 0 2 2 1 0 TRAF-type zinc finger zf-C3HC4_4 PF15227.6 EFC37858.1 - 0.02 15.0 8.7 0.02 15.0 8.7 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EFC37858.1 - 0.029 14.3 11.9 0.029 14.3 11.9 2.8 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) BTB_2 PF02214.22 EFC37858.1 - 0.096 13.1 0.2 0.35 11.3 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain TMPIT PF07851.13 EFC37858.1 - 0.65 9.2 3.3 1 8.5 3.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein Exonuc_VII_L PF02601.15 EFC37858.1 - 0.9 9.0 3.7 1.2 8.7 3.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TssC PF17541.2 EFC37858.1 - 0.91 8.3 5.2 0.16 10.7 1.3 1.7 2 0 0 2 2 2 0 Type VI secretion system, TssC, VipB zf-RING_6 PF14835.6 EFC37858.1 - 2.4 8.1 9.9 0.66 9.9 6.1 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3H2C3 PF17122.5 EFC37858.1 - 4.9 7.3 15.0 2 8.5 12.3 1.8 2 0 0 2 2 2 0 Zinc-finger DUF1272 PF06906.11 EFC37858.1 - 5.9 7.1 12.0 2 8.6 8.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-Nse PF11789.8 EFC37858.1 - 6.5 6.7 10.4 44 4.0 10.4 2.5 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit M11L PF11099.8 EFC37859.1 - 0.023 15.0 1.4 0.023 15.0 1.4 2.3 2 0 0 2 2 2 0 Apoptosis regulator M11L like Zn_clus PF00172.18 EFC37860.1 - 0.00068 19.7 16.0 0.0012 18.9 16.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_8 PF13188.7 EFC37860.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 PAS domain RCC1 PF00415.18 EFC37861.1 - 1.2e-20 73.8 4.4 0.012 16.2 0.0 8.4 7 2 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37861.1 - 3.6e-18 64.9 18.3 8.8e-06 25.4 0.0 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PB1 PF00564.24 EFC37862.1 - 0.016 15.1 0.9 0.14 12.1 0.5 2.4 2 0 0 2 2 2 0 PB1 domain GST_N_3 PF13417.6 EFC37863.1 - 7.6e-16 58.3 0.0 1.4e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC37863.1 - 9.3e-15 54.7 0.0 1.8e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFC37863.1 - 1.4e-14 54.2 0.0 2.4e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC37863.1 - 8.9e-14 51.5 0.0 1.2e-13 51.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC37863.1 - 1.1e-06 28.5 0.0 2.3e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC37863.1 - 3.5e-06 27.1 0.0 6.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain polyprenyl_synt PF00348.17 EFC37864.1 - 3.5e-69 232.7 0.0 4.5e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 EFC37864.1 - 0.0017 18.0 0.1 0.0031 17.1 0.1 1.4 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 VIT PF08487.10 EFC37865.1 - 4.8e-18 65.4 0.3 1.4e-17 63.9 0.3 1.9 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2135 PF09906.9 EFC37865.1 - 3.5e-08 33.6 0.2 9.5e-08 32.2 0.2 1.8 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2135) TPR_9 PF13371.6 EFC37865.1 - 0.017 15.3 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37865.1 - 0.034 14.5 0.0 0.077 13.3 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat YkyA PF10368.9 EFC37865.1 - 0.045 13.4 2.9 0.12 12.0 2.9 1.7 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein TPR_14 PF13428.6 EFC37865.1 - 0.081 13.8 0.1 0.28 12.1 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC37865.1 - 0.09 12.7 0.1 6.5 6.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat CTD_bind PF04818.13 EFC37865.1 - 0.12 13.2 0.2 0.37 11.7 0.2 1.8 1 0 0 1 1 1 0 RNA polymerase II-binding domain. TPR_1 PF00515.28 EFC37865.1 - 0.16 11.9 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat NHL PF01436.21 EFC37866.1 - 2.4e-35 118.8 8.0 2.2e-06 27.4 0.1 6.7 6 0 0 6 6 6 6 NHL repeat Linker_histone PF00538.19 EFC37866.1 - 9.3e-08 32.3 0.0 15 6.0 0.0 5.1 5 0 0 5 5 5 0 linker histone H1 and H5 family TGT_C2 PF14810.6 EFC37866.1 - 0.00039 20.5 0.0 32 4.8 0.0 4.7 5 0 0 5 5 5 0 Patch-forming domain C2 of tRNA-guanine transglycosylase MJ1316 PF04457.12 EFC37866.1 - 0.00041 21.0 1.1 79 4.1 0.0 4.7 5 0 0 5 5 5 0 MJ1316 RNA cyclic group end recognition domain ParBc_2 PF08857.11 EFC37866.1 - 0.0026 17.9 0.0 3.1 7.8 0.0 4.2 1 1 1 2 2 2 1 Putative ParB-like nuclease MHC_I_3 PF16497.5 EFC37866.1 - 0.0059 16.1 0.0 0.66 9.4 0.0 2.8 3 0 0 3 3 3 1 MHC-I family domain Plasmo_rep PF12135.8 EFC37866.1 - 0.011 15.2 33.0 1.7 8.3 0.3 7.9 9 0 0 9 9 9 0 Plasmodium repeat family potato_inhibit PF00280.18 EFC37866.1 - 0.049 14.3 1.8 64 4.3 0.0 4.3 5 0 0 5 5 5 0 Potato inhibitor I family DUF4792 PF16040.5 EFC37866.1 - 0.066 13.1 1.7 25 4.8 0.1 3.6 2 2 2 4 4 4 0 Domain of unknown function (DUF4792) NPH-II PF12011.8 EFC37866.1 - 0.1 12.5 5.0 25 4.7 0.0 4.2 1 1 2 5 5 5 0 RNA helicase NPH-II Coatomer_WDAD PF04053.14 EFC37866.1 - 0.39 9.7 6.8 11 4.9 0.2 3.4 1 1 2 4 4 4 0 Coatomer WD associated region Sua5_yciO_yrdC PF01300.18 EFC37866.1 - 0.7 9.4 2.8 96 2.4 0.0 3.7 5 0 0 5 5 5 0 Telomere recombination YdfZ PF14001.6 EFC37866.1 - 3.2 8.2 12.4 94 3.5 0.1 5.0 5 0 0 5 5 5 0 YdfZ protein BTB PF00651.31 EFC37867.1 - 6.3e-10 39.3 3.5 8.5e-10 38.9 0.4 2.7 3 0 0 3 3 3 1 BTB/POZ domain Clathrin-link PF09268.10 EFC37867.1 - 4.2 6.8 4.7 2.6 7.5 1.2 2.2 2 0 0 2 2 2 0 Clathrin, heavy-chain linker NmrA PF05368.13 EFC37868.1 - 2.5e-42 145.0 1.0 3.1e-42 144.7 1.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC37868.1 - 2.1e-20 73.4 0.4 5.4e-20 72.1 0.2 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC37868.1 - 1.6e-08 34.4 0.2 1.7e-07 31.0 0.1 2.3 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EFC37868.1 - 8.8e-07 29.1 3.4 1e-06 28.9 0.5 2.3 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.20 EFC37868.1 - 4.2e-06 26.9 0.4 9e-06 25.8 0.4 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 EFC37868.1 - 2.1e-05 23.7 0.1 4.2e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC37868.1 - 0.00018 21.0 0.9 0.17 11.3 0.1 3.0 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 EFC37868.1 - 0.00038 20.9 0.1 0.00083 19.8 0.1 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EFC37868.1 - 0.0015 17.8 1.3 0.0035 16.5 0.3 2.1 2 1 0 2 2 2 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 EFC37868.1 - 0.0017 18.7 1.4 0.0023 18.2 0.3 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GARS_N PF02844.15 EFC37868.1 - 0.0019 18.9 0.2 0.0068 17.2 0.1 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain DXP_reductoisom PF02670.16 EFC37868.1 - 0.0038 17.9 3.1 0.35 11.6 0.6 2.3 2 0 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Ldh_1_N PF00056.23 EFC37868.1 - 0.011 15.8 0.5 0.026 14.6 0.5 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain KR PF08659.10 EFC37868.1 - 0.02 14.8 0.5 0.045 13.7 0.5 1.6 1 0 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 EFC37868.1 - 0.025 13.7 0.8 1.7 7.7 0.2 2.7 2 1 1 3 3 3 0 Polysaccharide biosynthesis protein Peptidase_M4_C PF02868.15 EFC37868.1 - 0.11 12.3 0.9 0.56 10.1 0.9 2.1 1 1 0 1 1 1 0 Thermolysin metallopeptidase, alpha-helical domain DUF211 PF02680.14 EFC37868.1 - 0.17 12.0 1.9 0.89 9.8 0.2 2.4 2 1 0 2 2 2 0 Uncharacterized ArCR, COG1888 Sel1 PF08238.12 EFC37869.1 - 1e-61 204.0 44.2 2.2e-08 34.5 0.5 9.2 9 0 0 9 9 9 8 Sel1 repeat TPR_16 PF13432.6 EFC37869.1 - 1e-05 26.0 9.9 0.58 10.9 0.2 5.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC37869.1 - 1.2e-05 25.0 8.2 0.58 10.3 0.1 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37869.1 - 0.0019 18.2 0.8 0.0019 18.2 0.8 7.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37869.1 - 0.003 17.8 11.4 0.48 10.8 0.0 4.9 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC37869.1 - 0.0073 16.1 0.9 0.0073 16.1 0.9 8.2 11 0 0 11 11 11 2 Tetratricopeptide repeat MIT PF04212.18 EFC37869.1 - 0.014 15.5 18.2 0.096 12.8 0.6 5.0 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 EFC37869.1 - 0.022 15.6 2.9 3.1 8.9 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37869.1 - 0.024 15.3 20.1 0.57 10.9 0.1 7.2 6 2 2 8 8 8 0 Tetratricopeptide repeat CEBP_ZZ PF16366.5 EFC37869.1 - 0.39 11.0 2.6 0.98 9.7 2.6 1.6 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain PatG_D PF18047.1 EFC37869.1 - 0.55 10.7 4.0 3.9 8.0 0.2 3.4 4 0 0 4 4 4 0 PatG Domain DUF512 PF04459.12 EFC37869.1 - 0.65 9.2 7.2 7.2 5.8 0.1 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF512) ZZ PF00569.17 EFC37869.1 - 0.79 9.6 4.2 2 8.3 4.2 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type TPR_17 PF13431.6 EFC37869.1 - 3.2 8.3 13.8 4.8 7.8 0.1 5.4 4 2 2 6 6 6 0 Tetratricopeptide repeat Acyltransferase PF01553.21 EFC37870.1 - 3.6e-16 59.0 0.1 7.7e-16 57.9 0.1 1.6 1 0 0 1 1 1 1 Acyltransferase OFeT_1 PF16955.5 EFC37870.1 - 0.046 13.4 0.0 0.078 12.7 0.0 1.3 1 0 0 1 1 1 0 Ferrous iron uptake permease, iron-lead transporter DUF3169 PF11368.8 EFC37870.1 - 0.11 12.0 1.6 0.58 9.6 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Wzy_C PF04932.15 EFC37870.1 - 0.14 11.8 0.3 0.21 11.2 0.3 1.3 1 0 0 1 1 1 0 O-Antigen ligase Baculo_11_kDa PF06143.11 EFC37870.1 - 0.17 11.4 0.9 0.44 10.2 0.2 2.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family Lin-8 PF03353.15 EFC37871.1 - 0.0069 16.0 3.7 0.014 15.0 3.7 1.4 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Leo1 PF04004.13 EFC37872.1 - 4.3e-10 39.7 21.0 3.9e-09 36.6 18.2 3.2 1 1 1 2 2 2 1 Leo1-like protein Ig_3 PF13927.6 EFC37872.1 - 7 7.3 9.6 5.4 7.7 0.3 3.6 4 0 0 4 4 4 0 Immunoglobulin domain EAP30 PF04157.16 EFC37873.1 - 7.7e-70 234.8 0.2 8.7e-70 234.7 0.2 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family CTNNBL PF08216.11 EFC37873.1 - 0.32 11.2 3.6 1.1 9.4 1.0 2.2 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear AAA_18 PF13238.6 EFC37874.1 - 2.1e-05 25.1 0.0 3.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFC37874.1 - 0.0012 18.6 0.0 0.0037 17.0 0.0 1.6 1 1 1 2 2 2 1 Cytidylate kinase AAA_33 PF13671.6 EFC37874.1 - 0.0033 17.6 0.0 0.0035 17.5 0.0 1.3 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 EFC37874.1 - 0.0039 17.3 0.0 0.006 16.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate kinase Rad17 PF03215.15 EFC37874.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 EFC37874.1 - 0.021 15.0 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFC37874.1 - 0.023 14.0 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin CoaE PF01121.20 EFC37874.1 - 0.041 13.6 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase dNK PF01712.19 EFC37874.1 - 0.06 13.2 0.0 0.14 12.0 0.0 1.6 2 0 0 2 2 2 0 Deoxynucleoside kinase Meth_synt_2 PF01717.18 EFC37875.1 - 4.9e-160 532.1 0.0 2.4e-153 510.1 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 EFC37875.1 - 1.5e-120 402.5 0.0 4.9e-111 371.2 0.0 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain TPR_2 PF07719.17 EFC37876.1 - 0.019 15.1 0.1 0.047 13.8 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC37876.1 - 0.37 11.5 1.8 0.96 10.2 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4832 PF16116.5 EFC37877.1 - 3.9e-07 30.2 0.1 5.7e-07 29.6 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) DUF4874 PF16173.5 EFC37877.1 - 3.9e-06 26.6 0.0 7.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4874) Amino_oxidase PF01593.24 EFC37878.1 - 0.0026 17.1 0.0 0.0066 15.8 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Trans_coact PF16805.5 EFC37878.1 - 0.13 12.4 0.1 2 8.5 0.0 2.5 2 0 0 2 2 2 0 Phage late-transcription coactivator F-box-like PF12937.7 EFC37879.1 - 2.4e-09 36.9 2.4 0.00076 19.3 0.3 2.5 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EFC37879.1 - 4.2e-06 26.5 1.5 0.014 15.3 0.1 3.2 2 1 1 3 3 3 2 F-box domain GCR1_C PF12550.8 EFC37879.1 - 0.11 12.9 0.5 0.33 11.3 0.5 1.8 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes Cellulase PF00150.18 EFC37881.1 - 5.5e-51 173.6 0.3 6.2e-51 173.5 0.3 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Tektin PF03148.14 EFC37882.1 - 0.007 15.2 0.8 0.013 14.3 0.8 1.3 1 0 0 1 1 1 1 Tektin family Imm5 PF14423.6 EFC37882.1 - 0.025 14.8 0.5 0.08 13.2 0.4 1.9 1 1 0 1 1 1 0 Immunity protein Imm5 TSC22 PF01166.18 EFC37882.1 - 0.54 10.6 5.1 18 5.7 0.6 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family TPR_2 PF07719.17 EFC37883.1 - 3.5e-09 36.1 1.3 0.035 14.2 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC37883.1 - 1.3e-07 31.2 6.3 0.038 13.8 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37883.1 - 1e-05 25.7 0.3 0.00074 19.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat F-box-like PF12937.7 EFC37883.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 F-box-like SHNi-TPR PF10516.9 EFC37883.1 - 0.021 14.3 0.1 6.2 6.4 0.0 2.6 2 0 0 2 2 2 0 SHNi-TPR OB_NTP_bind PF07717.16 EFC37883.1 - 0.11 12.8 0.0 0.32 11.4 0.0 1.8 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold F-box PF00646.33 EFC37883.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 F-box domain TPR_8 PF13181.6 EFC37883.1 - 1.1 9.6 3.3 16 6.0 0.0 3.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 EFC37884.1 - 4.5e-19 68.7 1.1 9.3e-15 54.6 0.1 3.2 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase PF00069.25 EFC37884.1 - 1.6e-18 67.1 0.1 4e-18 65.7 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC37884.1 - 0.027 13.3 0.0 0.047 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Shisa PF13908.6 EFC37884.1 - 0.045 14.0 0.1 0.091 13.0 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator VirB3 PF05101.13 EFC37884.1 - 0.098 12.9 0.9 0.23 11.7 0.9 1.5 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein LRR_6 PF13516.6 EFC37885.1 - 4.8e-15 54.3 5.5 0.0013 18.7 0.1 5.2 5 1 0 5 5 5 3 Leucine Rich repeat LRR_8 PF13855.6 EFC37885.1 - 2.8e-07 30.2 3.3 0.00024 20.8 0.8 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFC37885.1 - 1.1e-05 25.7 15.4 0.00014 22.1 2.2 3.8 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37885.1 - 0.097 13.3 7.8 3.8 8.4 0.1 4.3 4 2 0 4 4 4 0 Leucine Rich Repeat Guanylate_cyc PF00211.20 EFC37886.1 - 6.7e-17 61.7 0.3 1.3e-16 60.8 0.3 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC37886.1 - 1.5e-07 31.6 0.6 1.1e-06 28.9 0.1 2.6 2 0 0 2 2 2 1 PAS domain HNOBA PF07701.14 EFC37886.1 - 0.024 14.1 0.1 0.062 12.7 0.1 1.7 1 0 0 1 1 1 0 Heme NO binding associated PAS PF00989.25 EFC37886.1 - 0.027 14.5 0.0 0.069 13.2 0.0 1.8 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 EFC37886.1 - 0.049 13.7 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain PFK PF00365.20 EFC37886.1 - 0.051 12.9 1.0 0.33 10.2 0.1 2.2 2 0 0 2 2 2 0 Phosphofructokinase Osmo_CC PF08946.10 EFC37886.1 - 0.11 12.7 2.1 4 7.8 0.2 2.9 2 0 0 2 2 2 0 Osmosensory transporter coiled coil CTK3 PF12243.8 EFC37886.1 - 0.68 9.9 3.2 15 5.6 0.6 3.4 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 Hemerythrin PF01814.23 EFC37887.1 - 2.9e-05 24.7 0.1 5.4e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain Actin PF00022.19 EFC37888.1 - 1.4e-88 297.3 0.0 5.3e-88 295.4 0.0 1.7 1 1 0 1 1 1 1 Actin RCC1_2 PF13540.6 EFC37889.1 - 8.5e-29 98.7 19.5 4.7e-07 29.4 0.1 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC37889.1 - 4.3e-23 81.7 9.2 9.9e-08 32.5 0.1 7.3 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Ribonuc_L-PSP PF01042.21 EFC37889.1 - 0.12 12.4 0.0 0.37 10.8 0.0 1.8 1 0 0 1 1 1 0 Endoribonuclease L-PSP Kelch_5 PF13854.6 EFC37889.1 - 0.46 10.5 5.3 0.82 9.7 0.4 3.3 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 EFC37889.1 - 1.6 9.2 3.9 2.3 8.6 0.3 3.1 4 0 0 4 4 4 0 Kelch motif DUF1634 PF07843.11 EFC37890.1 - 0.059 13.4 3.3 0.24 11.5 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1634) Prominin PF05478.11 EFC37890.1 - 0.073 11.0 0.1 0.096 10.6 0.1 1.1 1 0 0 1 1 1 0 Prominin Tmpp129 PF10272.9 EFC37890.1 - 0.08 12.2 0.7 0.099 11.9 0.7 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor NPCC PF08058.11 EFC37890.1 - 0.24 11.5 2.0 0.43 10.6 0.0 2.0 1 1 1 2 2 2 0 Nuclear pore complex component DHHC PF01529.20 EFC37890.1 - 0.33 11.0 4.2 1.2 9.3 0.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase UPF0489 PF12640.7 EFC37891.1 - 6.6e-08 33.0 3.3 2.6e-07 31.0 3.3 2.0 1 1 0 1 1 1 1 UPF0489 domain NHL PF01436.21 EFC37892.1 - 1.3e-38 129.0 1.1 1.1e-06 28.4 0.0 9.9 9 0 0 9 9 9 7 NHL repeat SGL PF08450.12 EFC37892.1 - 3.6e-09 36.6 7.2 0.27 10.8 0.0 7.3 5 3 2 9 9 9 3 SMP-30/Gluconolactonase/LRE-like region RGS PF00615.19 EFC37892.1 - 7.8e-08 32.6 2.0 2.8e-07 30.8 2.0 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain EGF_2 PF07974.13 EFC37892.1 - 5.1e-07 29.9 25.8 0.00048 20.4 6.5 2.7 2 0 0 2 2 2 2 EGF-like domain GPS PF01825.21 EFC37892.1 - 1.1e-06 29.1 6.0 2.9e-06 27.7 6.0 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Phytase-like PF13449.6 EFC37892.1 - 0.076 12.9 0.0 1.9 8.3 0.0 2.6 2 0 0 2 2 2 0 Esterase-like activity of phytase TGT_C2 PF14810.6 EFC37892.1 - 0.11 12.7 0.1 11 6.2 0.0 3.6 3 0 0 3 3 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase Arylesterase PF01731.20 EFC37892.1 - 0.17 12.1 2.6 7.2 6.9 0.0 4.9 4 0 0 4 4 4 0 Arylesterase K1 PF02960.14 EFC37892.1 - 0.46 10.6 5.6 0.13 12.3 0.7 2.8 2 0 0 2 2 1 0 K1 glycoprotein Bac_export_2 PF01312.19 EFC37892.1 - 3.1 6.9 16.7 0.75 9.0 12.9 1.8 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family SBBP PF06739.11 EFC37892.1 - 3.8 7.6 10.5 9.8 6.3 1.2 4.8 4 0 0 4 4 4 0 Beta-propeller repeat DUF3082 PF11282.8 EFC37892.1 - 8.7 6.7 9.6 0.51 10.6 0.2 3.7 3 0 0 3 3 2 0 Protein of unknown function (DUF3082) RGS PF00615.19 EFC37893.1 - 1.3e-08 35.1 4.3 1.7e-08 34.8 1.1 2.8 2 1 0 2 2 2 1 Regulator of G protein signaling domain CHASE4 PF05228.13 EFC37893.1 - 1.7e-08 34.8 0.2 4.9e-08 33.3 0.1 1.9 2 0 0 2 2 2 1 CHASE4 domain Qua1 PF16274.5 EFC37893.1 - 0.044 13.6 0.0 0.14 12.0 0.0 1.9 1 0 0 1 1 1 0 Qua1 domain Tetraspanin PF00335.20 EFC37893.1 - 0.057 13.1 1.8 0.44 10.2 0.4 2.3 2 0 0 2 2 2 0 Tetraspanin family DUF4267 PF14087.6 EFC37893.1 - 0.17 12.0 0.0 0.42 10.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4267) Pox_H7 PF04787.12 EFC37893.1 - 0.25 11.8 5.0 1.5 9.4 0.1 3.1 3 0 0 3 3 3 0 Late protein H7 KMP11 PF03037.16 EFC37893.1 - 2.9 8.7 9.7 0.18 12.6 1.4 2.9 3 0 0 3 3 3 0 Kinetoplastid membrane protein 11 Peptidase_C1 PF00112.23 EFC37894.1 - 3.9e-55 187.3 3.1 5.8e-55 186.7 3.1 1.2 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFC37894.1 - 1.5e-37 128.6 0.4 2.6e-37 127.7 0.4 1.4 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EFC37894.1 - 0.00062 18.7 1.1 0.0015 17.3 0.1 2.0 2 0 0 2 2 2 1 Peptidase C1-like family Amino_oxidase PF01593.24 EFC37895.1 - 2.6e-31 109.4 0.0 2.9e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HECW_N PF16562.5 EFC37897.1 - 0.0073 16.1 0.9 0.018 14.9 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 DUF2779 PF11074.8 EFC37899.1 - 0.0062 17.0 1.0 0.022 15.2 0.2 2.5 2 1 0 2 2 2 1 Domain of unknown function(DUF2779) SseB PF07179.12 EFC37899.1 - 0.045 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 SseB protein N-terminal domain DUF4116 PF13475.6 EFC37901.1 - 8.3e-34 115.1 5.8 3.8e-16 58.5 0.0 4.6 4 1 1 5 5 5 4 Domain of unknown function (DUF4116) DUF3666 PF12408.8 EFC37901.1 - 0.012 14.9 2.3 10 5.4 0.0 4.2 4 0 0 4 4 4 0 Ribose-5-phosphate isomerase DNA_gyraseA_C PF03989.13 EFC37901.1 - 0.051 13.1 0.1 6.5 6.3 0.0 3.4 3 1 1 4 4 4 0 DNA gyrase C-terminal domain, beta-propeller Lgl_C PF08596.10 EFC37901.1 - 0.053 12.2 0.0 0.077 11.7 0.0 1.3 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal Pox_A3L PF05288.11 EFC37901.1 - 2.9 7.9 5.6 4.7 7.3 0.0 3.5 3 2 1 4 4 4 0 Poxvirus A3L Protein TPR_1 PF00515.28 EFC37903.1 - 4.3e-05 23.2 4.8 0.098 12.5 0.5 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC37903.1 - 0.0002 21.2 6.9 0.41 10.9 0.0 4.5 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC37903.1 - 0.00028 20.5 1.3 3.9 7.2 0.1 3.8 3 0 0 3 3 3 1 TPR repeat ANAPC3 PF12895.7 EFC37903.1 - 0.0016 18.6 2.6 1.8 8.8 0.0 3.6 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC37903.1 - 0.0017 18.8 0.1 17 6.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC37903.1 - 0.0029 17.8 0.6 2.9 8.3 0.1 3.7 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC37903.1 - 0.022 15.5 0.0 5.9 8.0 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EFC37903.1 - 0.026 15.0 0.0 0.11 12.9 0.0 2.0 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_6 PF13174.6 EFC37903.1 - 0.039 14.6 0.7 15 6.5 0.0 4.4 5 1 0 5 5 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC37903.1 - 0.047 13.1 0.1 0.17 11.4 0.0 2.1 2 0 0 2 2 2 0 SHNi-TPR TPR_7 PF13176.6 EFC37903.1 - 0.19 11.8 3.1 4.8 7.4 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC37903.1 - 0.45 11.0 6.9 0.44 11.0 0.8 3.6 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC37903.1 - 7.5 7.0 12.2 18 5.8 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF778 PF05608.12 EFC37904.1 - 9.8e-29 101.1 4.2 5.3e-21 75.8 0.1 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF778) DUF4796 PF16044.5 EFC37904.1 - 0.00011 21.9 0.2 0.00011 21.9 0.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4796) Peptidase_C97 PF05903.14 EFC37904.1 - 0.0065 16.3 3.2 0.014 15.2 3.2 1.5 1 0 0 1 1 1 1 PPPDE putative peptidase domain CDC45 PF02724.14 EFC37904.1 - 0.028 12.7 0.1 0.029 12.7 0.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Pex14_N PF04695.13 EFC37904.1 - 0.035 14.8 0.0 0.055 14.1 0.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CorA PF01544.18 EFC37905.1 - 0.0015 17.9 0.1 0.0025 17.2 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein CPSase_L_D2 PF02786.17 EFC37906.1 - 1.5e-103 344.8 0.1 4.8e-82 274.6 0.1 3.3 3 0 0 3 3 3 3 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 EFC37906.1 - 6.5e-45 152.1 0.0 2.1e-44 150.4 0.0 2.0 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 EFC37906.1 - 2.1e-41 141.8 0.1 6.8e-41 140.1 0.1 2.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_L_D3 PF02787.19 EFC37906.1 - 5.3e-30 104.3 1.8 3.9e-29 101.5 1.8 2.6 1 1 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 EFC37906.1 - 5.8e-12 45.5 0.0 7.4e-07 28.9 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFC37906.1 - 3.6e-10 39.7 0.4 8.9e-06 25.4 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 EFC37906.1 - 9.2e-05 22.2 0.0 0.0025 17.5 0.0 2.6 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 EFC37906.1 - 0.017 15.2 0.3 0.083 12.9 0.1 2.2 2 0 0 2 2 2 0 ATP-grasp domain CDPS PF16715.5 EFC37906.1 - 0.028 14.1 0.2 0.059 13.0 0.2 1.5 1 0 0 1 1 1 0 Cyclodipeptide synthase Peptidase_C26 PF07722.13 EFC37906.1 - 0.032 14.0 0.3 0.18 11.5 0.3 2.4 1 1 0 1 1 1 0 Peptidase C26 Kinesin PF00225.23 EFC37907.1 - 6.4e-89 298.2 4.8 6.4e-89 298.2 4.8 2.9 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC37907.1 - 1.9e-22 79.8 0.2 1.9e-22 79.8 0.2 3.6 2 0 0 2 2 2 1 Microtubule binding U62_UL91 PF17442.2 EFC37907.1 - 0.1 12.6 0.4 0.57 10.2 0.1 2.4 2 0 0 2 2 2 0 Functional domain of U62 and UL91 proteins WD40_alt PF14077.6 EFC37907.1 - 4.9 7.1 7.0 11 6.0 1.1 3.1 3 0 0 3 3 3 0 Alternative WD40 repeat motif WD40 PF00400.32 EFC37908.1 - 1.5e-32 111.1 23.4 0.0059 17.4 0.1 11.7 13 0 0 13 13 13 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC37908.1 - 2.2e-17 63.1 0.2 0.024 15.0 0.0 7.7 3 3 4 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC37908.1 - 0.00021 20.7 5.5 0.83 8.9 0.1 4.1 4 0 0 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 EFC37908.1 - 0.039 12.9 0.1 6.9 5.5 0.0 3.4 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 EFC37908.1 - 0.041 14.4 0.8 24 5.6 0.0 5.0 6 0 0 6 6 6 0 PQQ-like domain DUF4116 PF13475.6 EFC37909.1 - 2e-140 456.4 89.8 1.5e-15 56.7 0.1 21.6 10 7 10 23 23 23 22 Domain of unknown function (DUF4116) DUF5615 PF18480.1 EFC37909.1 - 0.0012 18.6 0.5 0.18 11.6 0.0 4.7 6 0 0 6 6 6 1 Domain of unknown function (DUF5615) ROQ_II PF18386.1 EFC37909.1 - 0.34 10.8 3.0 56 3.7 0.1 4.6 5 0 0 5 5 5 0 Roquin II domain Actin PF00022.19 EFC37910.1 - 1.4e-97 326.9 0.1 1.2e-80 271.1 0.0 3.0 1 1 1 2 2 2 2 Actin FtsA PF14450.6 EFC37910.1 - 0.13 12.7 0.0 7.7 7.0 0.0 2.5 2 1 0 2 2 2 0 Cell division protein FtsA MreB_Mbl PF06723.13 EFC37910.1 - 0.15 10.8 0.0 0.37 9.6 0.0 1.6 2 0 0 2 2 2 0 MreB/Mbl protein VCBS PF13517.6 EFC37911.1 - 0.058 14.0 0.1 0.37 11.4 0.0 2.3 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella B12D PF06522.11 EFC37911.1 - 0.09 12.6 0.0 1.3 8.8 0.1 2.3 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit AAA_12 PF13087.6 EFC37912.1 - 7.2e-47 159.6 0.2 7.2e-47 159.6 0.2 2.3 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.6 EFC37912.1 - 8.6e-30 104.4 5.9 1.2e-13 51.4 0.0 3.7 3 1 1 4 4 4 2 AAA domain AAA_19 PF13245.6 EFC37912.1 - 3.7e-11 43.6 0.4 3.6e-08 33.8 0.0 3.7 3 1 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFC37912.1 - 4.7e-10 39.5 0.0 3.5e-09 36.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 EFC37912.1 - 0.00054 19.5 0.0 0.011 15.2 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 EFC37912.1 - 0.0014 18.7 0.0 0.0014 18.7 0.0 2.8 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 EFC37912.1 - 0.002 17.7 0.7 0.028 13.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region UvrD-helicase PF00580.21 EFC37912.1 - 0.0026 17.4 0.0 0.0026 17.4 0.0 3.3 4 1 0 4 4 3 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EFC37912.1 - 0.0028 17.9 0.1 0.99 9.7 0.0 3.9 4 0 0 4 4 4 1 AAA domain DEAD PF00270.29 EFC37912.1 - 0.0095 15.7 0.0 0.043 13.6 0.0 2.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_25 PF13481.6 EFC37912.1 - 0.018 14.7 0.0 0.042 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFC37912.1 - 0.024 15.1 0.0 0.14 12.6 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) HSP70 PF00012.20 EFC37913.1 - 8.9e-85 285.1 0.0 1.1e-84 284.8 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Beta_helix PF13229.6 EFC37914.1 - 2.4e-11 43.7 37.5 1.3e-09 38.1 23.0 4.7 2 1 3 5 5 5 4 Right handed beta helix region Macin PF14865.6 EFC37914.1 - 0.016 15.7 0.2 0.041 14.4 0.2 1.7 1 0 0 1 1 1 0 Macin Sec23_trunk PF04811.15 EFC37915.1 - 9.3e-61 205.5 0.0 2.7e-60 204.0 0.0 1.7 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFC37915.1 - 5e-28 97.7 0.2 1.2e-27 96.5 0.2 1.7 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 EFC37915.1 - 3.6e-23 81.3 0.1 7.4e-23 80.3 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 EFC37915.1 - 3.9e-13 49.2 2.7 8.7e-13 48.1 2.7 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 EFC37915.1 - 1.2e-08 34.7 0.0 3.1e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat WGG PF10273.9 EFC37916.1 - 1.2e-12 48.3 0.5 1.2e-12 48.3 0.5 1.6 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 eIF-3_zeta PF05091.12 EFC37917.1 - 0.025 13.6 0.3 0.033 13.2 0.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) BRCT_2 PF16589.5 EFC37917.1 - 0.03 14.7 0.1 0.064 13.7 0.1 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain GTP_EFTU PF00009.27 EFC37918.1 - 1.7e-54 184.3 0.1 3.1e-54 183.5 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC37918.1 - 1.9e-39 134.4 0.1 4.4e-39 133.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC37918.1 - 1.6e-13 50.9 0.1 5.9e-13 49.0 0.1 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC37918.1 - 7.6e-09 35.7 0.5 7.1e-06 26.1 0.0 2.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase NIF3 PF01784.18 EFC37918.1 - 0.0019 17.9 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Roc PF08477.13 EFC37918.1 - 0.011 15.9 1.0 0.078 13.2 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 EFC37918.1 - 0.012 15.5 0.5 0.038 13.9 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 SRPRB PF09439.10 EFC37918.1 - 0.013 14.9 0.1 0.037 13.4 0.1 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC37918.1 - 0.16 11.6 1.6 0.23 11.0 0.1 1.9 2 0 0 2 2 2 0 Ras family Glutaredoxin PF00462.24 EFC37919.1 - 3.2e-16 59.3 0.1 1.5e-15 57.2 0.0 1.9 2 0 0 2 2 2 1 Glutaredoxin GST_N_2 PF13409.6 EFC37919.1 - 0.00016 21.9 0.0 0.00027 21.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_2 PF13098.6 EFC37919.1 - 0.0016 18.9 0.3 0.0062 17.0 0.1 2.0 1 1 1 2 2 2 1 Thioredoxin-like domain DUF836 PF05768.14 EFC37919.1 - 0.0041 17.5 0.0 0.0076 16.6 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 EFC37919.1 - 0.011 15.8 0.0 0.022 14.8 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin domain Thioredoxin PF00085.20 EFC37919.1 - 0.036 14.0 0.0 0.052 13.5 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin Thioredoxin_9 PF14595.6 EFC37919.1 - 0.053 13.3 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin E3_UbLigase_RBR PF18091.1 EFC37919.1 - 0.069 13.3 0.3 7.4 6.8 0.0 2.2 2 0 0 2 2 2 0 E3 Ubiquitin Ligase RBR C-terminal domain GST_N_3 PF13417.6 EFC37919.1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain TraF PF13728.6 EFC37919.1 - 0.13 12.1 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Pkinase PF00069.25 EFC37920.1 - 2.4e-55 187.8 0.3 5.8e-55 186.5 0.1 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37920.1 - 1.4e-34 119.6 0.1 2.3e-34 118.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC37920.1 - 0.00029 20.2 0.1 0.015 14.6 0.0 2.6 2 1 1 3 3 3 1 Kinase-like APH PF01636.23 EFC37920.1 - 0.024 14.6 0.0 0.21 11.5 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family FtsX PF02687.21 EFC37921.1 - 0.00025 21.4 2.8 0.51 10.8 0.2 2.6 2 0 0 2 2 2 2 FtsX-like permease family Guanylate_cyc PF00211.20 EFC37921.1 - 0.0034 17.0 0.0 0.0072 16.0 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Wzz PF02706.15 EFC37921.1 - 0.15 12.4 3.9 9.8 6.6 0.2 2.6 2 0 0 2 2 2 0 Chain length determinant protein F-box PF00646.33 EFC37922.1 - 0.034 14.0 0.1 0.081 12.8 0.1 1.6 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC37922.1 - 0.045 13.6 0.3 0.12 12.2 0.3 1.7 1 0 0 1 1 1 0 F-box-like IglC PF11550.8 EFC37922.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Intracellular growth locus C protein DUF1406 PF07190.11 EFC37923.1 - 0.075 13.0 0.5 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1406) FTA2 PF13095.6 EFC37924.1 - 0.11 12.1 0.2 0.23 11.1 0.2 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 SPX PF03105.19 EFC37924.1 - 3.7 7.4 32.7 8.8 6.1 27.2 2.2 2 0 0 2 2 2 0 SPX domain AT_hook PF02178.19 EFC37925.1 - 0.0009 18.9 2.1 0.0029 17.3 2.1 1.9 1 0 0 1 1 1 1 AT hook motif Phage_TAC_5 PF08890.11 EFC37925.1 - 0.17 11.9 1.3 0.24 11.4 1.3 1.2 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC AT_hook PF02178.19 EFC37926.1 - 0.0017 18.0 2.7 0.0035 17.0 2.7 1.6 1 0 0 1 1 1 1 AT hook motif ketoacyl-synt PF00109.26 EFC37927.1 - 6.1e-59 199.6 0.0 1.6e-58 198.3 0.0 1.7 2 0 0 2 2 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFC37927.1 - 9.6e-47 160.0 0.0 2.1e-46 158.9 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFC37927.1 - 6.4e-42 143.5 0.0 3.1e-41 141.2 0.0 2.1 2 0 0 2 2 2 1 KR domain Ketoacyl-synt_C PF02801.22 EFC37927.1 - 2.7e-36 124.1 0.1 5.4e-36 123.2 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 EFC37927.1 - 7.5e-32 110.8 0.0 1.2e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 EFC37927.1 - 2.6e-18 66.5 0.0 7.6e-18 65.0 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 EFC37927.1 - 1.4e-16 61.0 0.0 1.3e-15 58.0 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain PP-binding PF00550.25 EFC37927.1 - 1.5e-12 47.6 0.3 4.1e-12 46.3 0.3 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 EFC37927.1 - 3e-11 43.4 0.0 1.1e-10 41.6 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC37927.1 - 7.9e-08 32.9 0.0 6e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain LCM PF04072.14 EFC37927.1 - 3.3e-07 30.4 0.0 7.3e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Methyltransf_11 PF08241.12 EFC37927.1 - 1.8e-06 28.5 0.0 1.1e-05 26.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC37927.1 - 4.3e-06 26.7 0.0 9.5e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Thioesterase PF00975.20 EFC37927.1 - 7.9e-06 26.1 0.0 1.9e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Thioesterase domain adh_short PF00106.25 EFC37927.1 - 0.00052 19.5 0.0 0.0012 18.3 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Hydrolase_4 PF12146.8 EFC37927.1 - 0.0087 15.4 0.0 0.14 11.4 0.0 2.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 EFC37927.1 - 0.037 13.9 0.0 0.49 10.2 0.0 2.7 2 0 0 2 2 2 0 Lipase (class 3) Methyltransf_16 PF10294.9 EFC37927.1 - 0.1 12.3 0.0 0.37 10.5 0.0 2.0 1 0 0 1 1 1 0 Lysine methyltransferase MINDY_DUB PF04424.13 EFC37927.1 - 0.41 10.7 2.7 8 6.5 0.1 3.6 3 0 0 3 3 3 0 MINDY deubiquitinase TLD PF07534.16 EFC37928.1 - 1.3e-17 64.4 0.3 2.4e-17 63.4 0.3 1.5 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFC37928.1 - 0.00048 20.4 0.0 0.00089 19.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 EFC37928.1 - 0.0019 18.3 0.0 0.0054 16.8 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain zf-C3HC4_2 PF13923.6 EFC37928.1 - 0.016 15.1 11.2 0.016 15.1 11.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Lar_restr_allev PF14354.6 EFC37928.1 - 0.065 13.6 0.9 0.065 13.6 0.9 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-C3H2C3 PF17122.5 EFC37928.1 - 0.07 13.2 8.4 0.22 11.6 8.4 1.9 1 0 0 1 1 1 0 Zinc-finger zf-TRAF PF02176.18 EFC37928.1 - 0.096 13.4 1.2 0.096 13.4 1.2 2.6 4 0 0 4 4 2 0 TRAF-type zinc finger E6 PF00518.17 EFC37928.1 - 0.1 13.0 3.7 0.26 11.7 3.7 1.6 1 0 0 1 1 1 0 Early Protein (E6) zf-C3HC4_3 PF13920.6 EFC37928.1 - 0.64 9.9 14.5 0.042 13.7 6.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Mu-like_Com PF10122.9 EFC37928.1 - 0.73 9.3 6.2 0.28 10.7 0.6 2.3 2 0 0 2 2 2 0 Mu-like prophage protein Com zf_C2H2_13 PF18508.1 EFC37928.1 - 1.5 8.5 8.1 0.17 11.5 2.6 2.3 2 0 0 2 2 2 0 Zinc finger domain zf-C2HC5 PF06221.13 EFC37928.1 - 1.6 8.8 14.9 0.27 11.3 0.8 3.1 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type zf-RING_2 PF13639.6 EFC37928.1 - 5 7.5 16.4 0.79 10.1 8.7 2.8 2 0 0 2 2 2 0 Ring finger domain DUF1272 PF06906.11 EFC37928.1 - 5.4 7.2 13.2 0.66 10.1 6.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-C3HC4_4 PF15227.6 EFC37928.1 - 6.8 6.9 13.3 1.1 9.5 7.1 2.9 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING NHL PF01436.21 EFC37929.1 - 1.7e-94 305.4 14.6 6.4e-08 32.2 0.0 16.6 16 0 0 16 16 16 14 NHL repeat SGL PF08450.12 EFC37929.1 - 1.8e-12 47.4 13.2 0.00042 20.0 0.6 6.9 1 1 7 8 8 8 7 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC37929.1 - 9.2e-12 45.5 4.9 0.35 10.8 0.1 10.5 6 4 3 12 12 12 2 Esterase-like activity of phytase Str_synth PF03088.16 EFC37929.1 - 1.9e-05 24.7 2.7 3.4 7.9 0.0 7.8 9 1 0 9 9 9 1 Strictosidine synthase DUF4431 PF14485.6 EFC37929.1 - 0.14 11.9 4.7 85 3.1 0.0 6.1 9 0 0 9 9 9 0 Domain of unknown function (DUF4431) Linker_histone PF00538.19 EFC37929.1 - 3.9 7.9 14.6 80 3.7 0.0 7.9 11 0 0 11 11 11 0 linker histone H1 and H5 family SIR2 PF02146.17 EFC37931.1 - 2.4e-12 47.1 0.0 8.7e-12 45.3 0.0 1.9 2 0 0 2 2 2 1 Sir2 family BTB PF00651.31 EFC37932.1 - 6.3e-07 29.6 6.0 8.7e-06 25.9 0.2 3.5 2 2 2 4 4 4 2 BTB/POZ domain STD1 PF17235.2 EFC37932.1 - 0.02 14.6 5.4 0.095 12.3 0.2 2.6 2 1 0 2 2 2 0 STD1/MTH1 DUF4024 PF13216.6 EFC37932.1 - 3.2 7.8 5.3 3.2 7.8 2.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) ZZ PF00569.17 EFC37934.1 - 2.2e-15 56.2 24.5 3.2e-08 33.2 7.8 3.1 3 0 0 3 3 3 2 Zinc finger, ZZ type C1_2 PF03107.16 EFC37934.1 - 0.0067 16.7 31.3 0.012 15.9 10.6 4.2 4 1 0 4 4 4 2 C1 domain DUF726 PF05277.12 EFC37934.1 - 0.063 12.2 0.0 0.096 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Sgf11 PF08209.11 EFC37934.1 - 0.55 9.9 5.3 12 5.6 0.0 3.4 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) RCC1 PF00415.18 EFC37935.1 - 7.5e-32 109.7 1.1 1.2e-09 38.6 0.0 5.6 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC37935.1 - 7.4e-14 51.1 4.6 0.0039 16.9 0.0 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC37935.1 - 0.003 17.7 0.1 0.16 12.3 0.0 3.0 3 1 0 3 3 3 1 Putative heavy-metal chelation WW PF00397.26 EFC37937.1 - 2.1e-05 24.5 19.7 8.5 6.6 0.2 8.3 8 0 0 8 8 8 5 WW domain PBCV_basic_adap PF08789.10 EFC37937.1 - 1.1 9.5 4.5 14 5.9 0.8 3.0 3 0 0 3 3 3 0 PBCV-specific basic adaptor domain NmrA PF05368.13 EFC37938.1 - 3.9e-20 72.4 0.2 4.8e-20 72.1 0.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC37938.1 - 7e-15 55.4 0.0 9.2e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFC37938.1 - 0.00021 20.5 0.1 0.00045 19.4 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 EFC37938.1 - 0.0016 17.6 0.0 0.9 8.6 0.0 2.4 2 0 0 2 2 2 2 RmlD substrate binding domain Semialdhyde_dh PF01118.24 EFC37938.1 - 0.003 18.0 0.0 0.0056 17.1 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EFC37938.1 - 0.0055 15.9 0.3 0.16 11.1 0.0 2.3 1 1 1 2 2 2 1 Male sterility protein DUF676 PF05057.14 EFC37938.1 - 0.025 14.1 0.0 0.039 13.5 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DXP_reductoisom PF02670.16 EFC37938.1 - 0.032 15.0 0.1 0.068 13.9 0.1 1.6 1 1 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase ABC2_membrane_3 PF12698.7 EFC37938.1 - 0.034 13.3 0.1 0.046 12.8 0.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein GDP_Man_Dehyd PF16363.5 EFC37938.1 - 0.035 13.5 0.0 1.1 8.5 0.0 2.6 2 1 1 3 3 3 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC37938.1 - 0.15 11.5 0.0 0.47 9.9 0.0 1.9 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family LRR_6 PF13516.6 EFC37939.1 - 1.5e-21 74.5 10.2 0.00032 20.5 0.1 7.4 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.7 EFC37939.1 - 2.1e-19 69.3 10.9 2.2e-05 24.7 0.1 4.7 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37939.1 - 2.7e-19 68.7 13.2 4.5e-10 39.1 2.7 4.0 3 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC37939.1 - 6.3e-11 41.2 6.2 3.5 8.5 0.1 7.3 6 1 1 7 7 7 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC37939.1 - 4.5e-05 23.0 3.6 0.0041 16.7 0.5 2.2 1 1 1 2 2 2 2 Leucine-rich repeat F-box PF00646.33 EFC37939.1 - 0.0077 16.1 0.2 0.019 14.8 0.2 1.8 1 1 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC37939.1 - 0.021 14.7 0.1 0.042 13.7 0.1 1.5 1 0 0 1 1 1 0 F-box-like 14-3-3 PF00244.20 EFC37940.1 - 3.8e-29 101.8 0.3 4.2e-29 101.7 0.3 1.0 1 0 0 1 1 1 1 14-3-3 protein AlbA_2 PF04326.14 EFC37942.1 - 3.7e-11 43.4 0.0 1.4e-10 41.6 0.0 2.0 1 0 0 1 1 1 1 Putative DNA-binding domain BTB_2 PF02214.22 EFC37942.1 - 5.1e-05 23.5 0.1 0.00017 21.9 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain LRR_6 PF13516.6 EFC37943.1 - 1.9e-30 102.3 22.3 0.0033 17.4 0.0 10.6 10 0 0 10 10 10 9 Leucine Rich repeat LRR_8 PF13855.6 EFC37943.1 - 3.9e-25 87.4 22.3 3.8e-10 39.4 1.0 5.0 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC37943.1 - 1.1e-16 60.6 42.0 0.00022 21.5 0.6 8.0 2 2 9 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC37943.1 - 5.4e-09 35.4 16.1 9.4 7.2 0.0 10.3 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC37943.1 - 4.8e-05 22.9 12.3 0.082 12.4 2.8 3.6 1 1 3 4 4 4 4 Leucine-rich repeat F-box-like PF12937.7 EFC37943.1 - 0.0022 17.8 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 F-box-like Spore_YhaL PF14147.6 EFC37943.1 - 0.036 13.8 0.3 12 5.7 0.0 4.0 4 0 0 4 4 4 0 Sporulation protein YhaL F-box PF00646.33 EFC37943.1 - 0.064 13.2 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 F-box domain YmcE_antitoxin PF15939.5 EFC37943.1 - 0.074 13.2 0.0 15 5.8 0.0 2.9 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system RNA_pol_I_TF PF04090.12 EFC37943.1 - 0.29 10.6 8.1 1.3 8.5 0.2 3.8 2 2 2 4 4 4 0 RNA polymerase I specific initiation factor DUF1462 PF07315.11 EFC37943.1 - 1.7 9.0 4.1 29 5.0 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1462) Thioredoxin PF00085.20 EFC37944.1 - 8e-50 167.1 7.9 1.3e-15 57.2 0.0 4.2 3 1 0 3 3 3 3 Thioredoxin Thioredoxin_2 PF13098.6 EFC37944.1 - 5.1e-07 30.1 3.7 0.61 10.6 0.0 5.3 3 3 1 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFC37944.1 - 2e-06 27.4 3.7 0.14 11.4 0.1 3.3 1 1 2 3 3 3 3 OST3 / OST6 family, transporter family eIF-3_zeta PF05091.12 EFC37944.1 - 0.0047 16.0 2.0 0.0086 15.1 2.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NTNH_C PF08470.10 EFC37944.1 - 0.0051 16.7 0.5 0.016 15.1 0.1 1.9 2 0 0 2 2 2 1 Nontoxic nonhaemagglutinin C-terminal HyaE PF07449.11 EFC37944.1 - 0.0059 16.6 0.0 3.2 7.8 0.0 3.4 4 0 0 4 4 4 1 Hydrogenase-1 expression protein HyaE Coilin_N PF15862.5 EFC37944.1 - 0.022 14.6 0.0 92 2.8 0.0 2.9 2 1 0 2 2 2 0 Coilin N-terminus Glutaredoxin PF00462.24 EFC37944.1 - 0.046 14.0 0.4 0.46 10.7 0.1 2.6 2 1 0 2 2 2 0 Glutaredoxin CCDC32 PF14989.6 EFC37945.1 - 0.13 12.2 1.1 1.4 8.9 0.2 2.1 1 1 1 2 2 2 0 Coiled-coil domain containing 32 DUF4116 PF13475.6 EFC37946.1 - 3.1e-34 116.4 7.4 1.2e-10 40.9 0.1 6.7 3 2 4 7 7 7 6 Domain of unknown function (DUF4116) dCache_1 PF02743.18 EFC37947.1 - 3.2e-05 23.8 2.2 8.1e-05 22.5 2.2 1.7 1 0 0 1 1 1 1 Cache domain Guanylate_cyc PF00211.20 EFC37947.1 - 0.0012 18.5 0.2 0.0033 17.1 0.1 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain RL11D PF11088.8 EFC37947.1 - 0.74 10.1 3.6 54 4.2 0.0 4.3 2 1 3 5 5 5 0 Glycoprotein encoding membrane proteins RL5A and RL6 Ras PF00071.22 EFC37948.1 - 8.5e-43 145.8 0.0 2.3e-42 144.4 0.0 1.8 1 0 0 1 1 1 1 Ras family BTB PF00651.31 EFC37948.1 - 2.8e-22 79.0 7.6 2.4e-17 63.1 0.2 4.2 3 1 0 3 3 3 2 BTB/POZ domain Roc PF08477.13 EFC37948.1 - 2.8e-19 69.5 0.0 9.7e-19 67.8 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC37948.1 - 8e-05 22.2 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family BACK PF07707.15 EFC37948.1 - 0.0037 17.3 0.0 0.67 10.1 0.0 2.5 2 0 0 2 2 2 2 BTB And C-terminal Kelch BTB PF00651.31 EFC37949.1 - 3.8e-19 69.0 0.8 1.3e-17 64.1 0.2 2.4 2 0 0 2 2 2 1 BTB/POZ domain Trypan_PARP PF05887.11 EFC37949.1 - 0.00083 19.3 94.7 0.16 11.9 36.4 3.2 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) BACK PF07707.15 EFC37949.1 - 0.0017 18.5 0.0 0.38 10.9 0.0 2.4 2 0 0 2 2 2 2 BTB And C-terminal Kelch Abhydrolase_2 PF02230.16 EFC37950.1 - 3e-31 108.9 0.0 3.4e-31 108.7 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFC37950.1 - 1.5e-08 34.2 0.0 0.00054 19.3 0.0 2.0 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC37950.1 - 1.8e-05 24.3 0.0 0.029 13.9 0.0 2.1 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EFC37950.1 - 2.3e-05 24.3 0.0 0.00027 20.9 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 EFC37950.1 - 0.00025 20.7 0.0 0.00036 20.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Asp2 PF16929.5 EFC37950.1 - 0.00041 19.5 0.0 0.00057 19.0 0.0 1.1 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter Esterase_phd PF10503.9 EFC37950.1 - 0.00091 18.8 0.0 0.03 13.8 0.0 2.0 2 0 0 2 2 2 1 Esterase PHB depolymerase FSH1 PF03959.13 EFC37950.1 - 0.0039 16.9 0.0 0.008 15.9 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) BAAT_C PF08840.11 EFC37950.1 - 0.0097 15.8 0.2 1.5 8.7 0.0 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal AXE1 PF05448.12 EFC37950.1 - 0.026 13.2 0.0 0.042 12.5 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 EFC37950.1 - 0.031 13.9 0.7 4.5 6.8 0.3 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold DUF2974 PF11187.8 EFC37950.1 - 0.042 13.4 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Esterase PF00756.20 EFC37950.1 - 0.083 12.5 0.0 0.085 12.5 0.0 1.2 1 0 0 1 1 1 0 Putative esterase PGAP1 PF07819.13 EFC37950.1 - 0.16 11.6 0.0 0.36 10.5 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein EGF_2 PF07974.13 EFC37951.1 - 1.1e-20 73.7 180.4 0.0032 17.8 6.4 12.7 12 0 0 12 12 12 11 EGF-like domain REJ PF02010.15 EFC37951.1 - 2.2e-13 49.8 15.3 2.2e-13 49.8 15.3 4.5 4 1 0 4 4 4 2 REJ domain Orthoreo_P10 PF07204.11 EFC37951.1 - 0.0073 16.2 0.8 0.0073 16.2 0.8 2.3 2 0 0 2 2 2 1 Orthoreovirus membrane fusion protein p10 DUF3180 PF11377.8 EFC37951.1 - 0.11 12.7 0.5 0.17 12.0 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3180) Phi-29_GP4 PF05464.11 EFC37952.1 - 0.31 11.3 2.7 4.2 7.7 0.1 3.0 3 1 1 4 4 4 0 Phi-29-like late genes activator (early protein GP4) adh_short PF00106.25 EFC37953.1 - 8.5e-20 71.0 0.1 1.2e-18 67.3 0.1 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC37953.1 - 1.2e-12 48.0 0.0 8.9e-12 45.1 0.0 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFC37953.1 - 0.00061 19.3 0.0 0.00081 18.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family p450 PF00067.22 EFC37955.1 - 1.7e-74 251.2 0.0 2.1e-74 251.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PAS_9 PF13426.7 EFC37956.1 - 1.1e-15 57.7 0.2 4.4e-15 55.8 0.2 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC37956.1 - 8.4e-06 25.8 0.0 2.2e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC37956.1 - 0.0019 17.7 1.4 0.0025 17.3 0.1 1.9 2 0 0 2 2 2 1 Heme NO binding associated PAS_4 PF08448.10 EFC37956.1 - 0.061 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 EFC37956.1 - 0.07 13.2 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 PAS domain NIDO PF06119.14 EFC37956.1 - 0.13 13.3 0.7 1.6 9.7 0.0 3.2 3 0 0 3 3 3 0 Nidogen-like PsbH PF00737.20 EFC37956.1 - 6.9 6.5 9.9 26 4.6 0.6 3.2 2 0 0 2 2 2 0 Photosystem II 10 kDa phosphoprotein Guanylate_cyc PF00211.20 EFC37957.1 - 6.1e-45 153.1 0.2 7.3e-45 152.8 0.2 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain GST_C_3 PF14497.6 EFC37958.1 - 4.8e-21 74.8 0.3 7.3e-21 74.2 0.3 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC37958.1 - 5.4e-11 42.6 0.1 8.7e-11 41.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC37958.1 - 4.2e-08 33.4 0.1 2.1e-07 31.2 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC37958.1 - 7.5e-06 26.3 0.0 1.6e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC37958.1 - 9.6e-05 22.6 0.0 0.00019 21.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC37958.1 - 0.00016 21.6 0.0 0.00042 20.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 EFC37958.1 - 0.007 16.7 0.2 0.017 15.4 0.0 1.7 2 0 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EFC37958.1 - 0.011 16.4 0.0 0.029 15.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Pox_A11 PF05061.13 EFC37959.1 - 0.052 12.8 0.1 0.074 12.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus A11 Protein Erf4 PF10256.9 EFC37959.1 - 0.075 13.1 1.2 0.38 10.9 0.9 2.3 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family FAD_binding_7 PF03441.14 EFC37960.1 - 2.5e-60 203.5 0.1 3.7e-60 202.9 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EFC37960.1 - 1.6e-28 99.8 0.0 2.4e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 DNA photolyase HSP70 PF00012.20 EFC37961.1 - 1.6e-207 690.4 3.6 2e-207 690.1 3.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC37961.1 - 7.7e-17 61.1 0.7 6.7e-15 54.7 0.1 2.9 2 2 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EFC37961.1 - 1.1e-05 25.7 0.5 0.18 12.2 0.0 3.6 3 2 0 3 3 3 2 Cell division protein FtsA FGGY_C PF02782.16 EFC37961.1 - 0.0011 18.7 0.2 0.0034 17.1 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EFC37961.1 - 0.037 13.5 0.0 7.7 5.9 0.0 3.0 2 1 1 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family RuvX PF03652.15 EFC37961.1 - 0.18 12.2 0.7 0.95 9.8 0.0 2.5 3 0 0 3 3 3 0 Holliday junction resolvase Raco_middle PF17651.1 EFC37961.1 - 0.25 11.0 1.8 1.4 8.6 0.0 2.8 3 0 0 3 3 3 0 RACo middle region Sel1 PF08238.12 EFC37963.1 - 5.1e-23 81.0 5.2 8.9e-06 26.2 0.1 4.4 4 0 0 4 4 4 4 Sel1 repeat BTB_2 PF02214.22 EFC37965.1 - 2.6e-12 46.9 0.7 1.7e-10 41.1 0.7 2.7 1 1 0 1 1 1 1 BTB/POZ domain Cation_efflux PF01545.21 EFC37966.1 - 1.9e-21 76.8 11.5 3.2e-21 76.0 11.5 1.4 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFC37966.1 - 1.3e-09 38.1 0.0 2.7e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Fer2 PF00111.27 EFC37967.1 - 2.5e-09 36.9 1.3 1.1e-08 34.9 1.3 1.9 1 1 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer2_4 PF13510.6 EFC37967.1 - 0.032 14.3 0.2 0.13 12.4 0.1 1.9 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain DUF588 PF04535.12 EFC37968.1 - 0.47 10.2 1.6 1.6 8.5 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF588) Apolipoprotein PF01442.18 EFC37969.1 - 0.0054 16.6 0.5 0.0092 15.9 0.5 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EFC37969.1 - 0.14 12.2 0.8 0.29 11.2 0.3 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus STAT_alpha PF01017.20 EFC37969.1 - 0.32 10.9 12.8 0.029 14.3 6.6 2.5 3 0 0 3 3 3 0 STAT protein, all-alpha domain PRESAN PF09687.10 EFC37969.1 - 3 8.4 26.3 2.1 8.9 7.6 3.9 4 0 0 4 4 4 0 Plasmodium RESA N-terminal Exonuc_VII_L PF02601.15 EFC37969.1 - 3.5 7.1 6.2 1.3 8.5 3.1 1.8 2 0 0 2 2 2 0 Exonuclease VII, large subunit PIN_8 PF18476.1 EFC37969.1 - 5 6.9 11.2 1.8 8.4 7.5 2.1 2 1 0 2 2 2 0 PIN like domain KxDL PF10241.9 EFC37969.1 - 7.6 6.9 13.2 6.5 7.1 1.9 4.4 3 1 1 4 4 4 0 Uncharacterized conserved protein AAA_16 PF13191.6 EFC37970.1 - 0.043 14.2 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Imm6 PF14434.6 EFC37970.1 - 0.14 12.1 0.6 0.33 10.9 0.1 1.8 2 0 0 2 2 2 0 Immunity protein Imm6 USP7_ICP0_bdg PF12436.8 EFC37971.1 - 4e-65 219.5 0.1 4e-65 219.5 0.1 2.9 4 0 0 4 4 4 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH PF00443.29 EFC37971.1 - 7e-46 156.8 4.4 2e-45 155.3 4.4 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EFC37971.1 - 2.7e-41 141.6 8.3 2.7e-41 141.6 8.3 2.9 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH_1 PF13423.6 EFC37971.1 - 1e-24 87.7 0.4 4.9e-24 85.5 0.4 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFC37971.1 - 0.00011 21.9 1.0 0.23 11.2 0.0 3.6 3 0 0 3 3 3 2 Ubiquitin family Macoilin PF09726.9 EFC37972.1 - 0.079 11.5 4.9 0.1 11.1 4.9 1.2 1 0 0 1 1 1 0 Macoilin family NHL PF01436.21 EFC37973.1 - 0.0017 18.3 0.0 0.095 12.8 0.0 3.1 3 0 0 3 3 3 1 NHL repeat HlyIII PF03006.20 EFC37974.1 - 1.8e-24 86.7 22.9 5.2e-15 55.8 16.0 2.1 2 0 0 2 2 2 2 Haemolysin-III related Kazal_2 PF07648.15 EFC37975.1 - 1e-09 38.4 21.8 4.9e-08 33.0 5.9 3.7 4 0 0 4 4 4 2 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 EFC37975.1 - 0.002 18.1 6.9 0.002 18.1 6.9 4.3 4 0 0 4 4 4 2 Kazal-type serine protease inhibitor domain LRR_6 PF13516.6 EFC37976.1 - 1.1e-17 62.5 0.0 0.0037 17.2 0.0 4.5 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 EFC37976.1 - 9.4e-11 41.8 0.1 0.00073 19.9 0.0 2.7 3 0 0 3 3 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC37976.1 - 1.9e-09 37.2 0.3 0.0039 16.9 0.1 3.2 2 1 0 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EFC37976.1 - 8.9e-05 22.5 0.0 92 4.2 0.0 5.1 5 0 0 5 5 5 0 Leucine Rich Repeat CLU_N PF15044.6 EFC37976.1 - 0.036 14.4 0.3 19 5.7 0.0 3.4 1 1 0 2 2 2 0 Mitochondrial function, CLU-N-term HydF_dimer PF18128.1 EFC37976.1 - 0.037 14.1 0.1 9.8 6.3 0.0 2.2 2 0 0 2 2 2 0 Hydrogen maturase F dimerization domain ApoB100_C PF12491.8 EFC37976.1 - 0.044 13.8 2.8 22 5.1 0.1 4.1 2 2 2 4 4 4 0 Apolipoprotein B100 C terminal SAS-6_N PF16531.5 EFC37976.1 - 0.047 14.3 5.5 0.053 14.1 4.2 1.9 2 1 0 2 2 2 0 Centriolar protein SAS N-terminal Pep_deformylase PF01327.21 EFC37976.1 - 0.06 13.0 0.9 2.4 7.7 0.1 2.5 1 1 0 2 2 2 0 Polypeptide deformylase Dynein_heavy PF03028.15 EFC37976.1 - 0.063 13.4 0.4 0.12 12.4 0.4 1.5 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain F-box-like PF12937.7 EFC37976.1 - 0.21 11.5 0.5 0.35 10.8 0.5 1.3 1 0 0 1 1 1 0 F-box-like UPF0193 PF05250.11 EFC37976.1 - 0.45 10.3 2.8 13 5.5 0.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0193) Lipase_GDSL_2 PF13472.6 EFC37977.1 - 1.5e-06 28.7 0.0 3.4e-06 27.6 0.0 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CE2_N PF17996.1 EFC37977.1 - 0.0012 18.8 0.4 0.76 9.8 0.0 2.7 3 0 0 3 3 3 2 Carbohydrate esterase 2 N-terminal Lipase_GDSL PF00657.22 EFC37977.1 - 0.0054 16.7 0.0 0.0098 15.9 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Biotin_lipoyl PF00364.22 EFC37978.1 - 7.7e-10 38.5 0.0 1.4e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme UQ_con PF00179.26 EFC37979.1 - 3.2e-46 156.5 0.0 4.1e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC37979.1 - 0.0019 17.9 0.0 0.0029 17.3 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFC37979.1 - 0.0053 16.6 0.3 0.01 15.7 0.3 1.4 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 EFC37979.1 - 0.0065 16.7 0.9 0.016 15.5 0.7 1.8 1 1 0 1 1 1 1 RWD domain Cytomega_UL84 PF06284.11 EFC37979.1 - 0.087 11.3 0.7 0.095 11.2 0.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Tubulin PF00091.25 EFC37980.1 - 6.6e-49 166.8 0.4 1.4e-48 165.8 0.2 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC37980.1 - 1.9e-20 73.3 0.3 3.3e-20 72.5 0.3 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC37980.1 - 6.5e-05 23.2 0.0 0.00012 22.3 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFC37980.1 - 0.00018 21.3 0.0 0.00034 20.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain DUF3842 PF12953.7 EFC37980.1 - 0.22 11.9 0.0 0.66 10.4 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3842) Hemerythrin PF01814.23 EFC37982.1 - 2.8e-05 24.7 0.1 5.1e-05 23.9 0.1 1.4 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain HSP70 PF00012.20 EFC37983.1 - 4.8e-62 210.0 9.8 6.2e-62 209.6 9.8 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC37983.1 - 8.8e-12 44.5 0.2 5.3e-10 38.6 0.1 2.9 2 1 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 EFC37983.1 - 0.0001 22.7 0.1 0.0097 16.3 0.0 3.0 2 2 0 2 2 2 1 Cell division protein FtsA StbA PF06406.11 EFC37983.1 - 0.0017 17.6 1.1 0.0093 15.2 0.0 2.7 2 2 0 2 2 2 1 StbA protein Methyltransf_32 PF13679.6 EFC37983.1 - 0.03 14.3 0.5 0.087 12.8 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.32 EFC37984.1 - 8.4e-22 77.1 20.1 6.5e-06 26.8 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC37984.1 - 4.8e-07 30.0 0.0 3.9 7.8 0.0 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC37984.1 - 3.1e-05 24.0 0.0 0.38 10.6 0.0 3.2 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Zn_clus PF00172.18 EFC37985.1 - 2.4e-07 30.8 13.2 4.3e-07 29.9 13.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 EFC37986.1 - 1.3e-07 31.6 11.2 2.6e-07 30.6 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5052 PF16475.5 EFC37987.1 - 0.014 15.0 1.8 0.03 13.9 1.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5052) FYVE PF01363.21 EFC37987.1 - 0.12 12.5 3.5 0.53 10.5 3.5 2.1 1 1 0 1 1 1 0 FYVE zinc finger NHL PF01436.21 EFC37987.1 - 0.38 10.9 6.5 3.9 7.7 0.0 4.1 4 0 0 4 4 4 0 NHL repeat BRCT_2 PF16589.5 EFC37987.1 - 0.79 10.2 4.7 0.37 11.2 0.6 2.3 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Ntox50 PF15542.6 EFC37987.1 - 2.1 9.2 12.6 2.1 9.2 0.9 3.0 3 0 0 3 3 3 0 Bacterial toxin 50 SAP130_C PF16014.5 EFC37989.1 - 0.055 12.6 3.9 0.067 12.3 3.9 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus zf-CCCH_2 PF14608.6 EFC37989.1 - 1.5 9.4 19.8 1.1 9.9 1.0 3.8 3 2 0 3 3 3 0 RNA-binding, Nab2-type zinc finger PolyA_pol PF01743.20 EFC37990.1 - 6e-09 36.4 0.0 2.2e-08 34.6 0.0 2.0 2 0 0 2 2 2 1 Poly A polymerase head domain zf-CCCH_4 PF18044.1 EFC37990.1 - 0.0069 16.2 23.3 0.24 11.3 0.1 5.3 5 0 0 5 5 5 3 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFC37990.1 - 0.023 14.7 21.7 0.71 10.0 0.2 5.2 4 0 0 4 4 4 0 Zinc finger domain zf-CCHH PF10283.9 EFC37990.1 - 0.04 13.9 28.5 0.72 9.9 0.3 5.3 4 1 1 5 5 5 0 PBZ domain zf-CCCH PF00642.24 EFC37990.1 - 0.75 9.8 21.0 9 6.3 0.6 5.3 5 0 0 5 5 5 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) p450 PF00067.22 EFC37991.1 - 2.2e-54 184.9 1.6 4.4e-54 184.0 1.6 1.4 1 1 0 1 1 1 1 Cytochrome P450 DUF840 PF05801.11 EFC37991.1 - 0.048 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Lagovirus protein of unknown function (DUF840) Rhomboid PF01694.22 EFC37992.1 - 4.5e-23 81.9 7.1 8.5e-23 81.0 7.1 1.4 1 0 0 1 1 1 1 Rhomboid family Ycf66_N PF07444.11 EFC37992.1 - 0.087 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Ycf66 protein N-terminus Pkinase PF00069.25 EFC37993.1 - 2.9e-09 36.7 0.1 3.1e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC37993.1 - 0.031 13.6 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase RIO1 PF01163.22 EFC37993.1 - 0.06 12.9 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 RIO1 family BAMBI PF06211.12 EFC37993.1 - 0.17 12.2 0.0 0.24 11.7 0.0 1.2 1 0 0 1 1 1 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain PEMT PF04191.13 EFC37994.1 - 1.6e-56 189.2 15.6 8.3e-34 116.2 1.2 3.1 3 0 0 3 3 3 2 Phospholipid methyltransferase ICMT PF04140.14 EFC37994.1 - 0.25 11.8 4.1 3 8.3 0.6 3.3 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family F5_F8_type_C PF00754.25 EFC37995.1 - 3.8e-17 62.6 0.1 2.1e-07 31.1 0.0 3.2 3 0 0 3 3 3 3 F5/8 type C domain LRR_6 PF13516.6 EFC37996.1 - 4.1e-35 116.8 0.4 0.0052 16.7 0.0 8.6 9 0 0 9 9 9 8 Leucine Rich repeat LRR_8 PF13855.6 EFC37996.1 - 1.2e-24 85.8 0.1 8.2e-08 31.9 0.1 3.4 2 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC37996.1 - 2.9e-22 78.4 2.5 0.00053 20.3 0.0 5.6 1 1 4 6 6 6 6 Leucine Rich repeats (2 copies) RHH_3 PF12651.7 EFC37996.1 - 3.7e-14 52.4 0.2 0.17 11.8 0.0 7.3 1 1 7 8 8 8 3 Ribbon-helix-helix domain LRR_1 PF00560.33 EFC37996.1 - 4.2e-13 47.9 0.0 37 5.4 0.0 8.3 8 1 0 8 8 8 0 Leucine Rich Repeat Spidroin_N PF16763.5 EFC37996.1 - 0.0011 19.0 4.9 57 3.8 0.0 6.6 1 1 5 7 7 7 0 Major ampullate spidroin 1, spider silk protein 1, N-term UPF0193 PF05250.11 EFC37996.1 - 0.0029 17.4 9.8 1.5 8.6 0.2 3.9 1 1 3 4 4 4 2 Uncharacterised protein family (UPF0193) DUF4368 PF14287.6 EFC37996.1 - 0.011 16.1 5.1 17 5.8 0.1 4.7 4 1 0 4 4 4 0 Domain of unknown function (DUF4368) F-box-like PF12937.7 EFC37997.1 - 0.00012 21.8 0.1 0.00029 20.6 0.0 1.7 2 0 0 2 2 2 1 F-box-like DUF2315 PF10231.9 EFC37997.1 - 0.059 13.5 2.1 5 7.2 0.5 2.8 2 0 0 2 2 2 0 Apoptogenic protein 1 NHL PF01436.21 EFC37998.1 - 4.6e-31 105.3 5.1 2.3e-05 24.2 0.0 12.1 11 0 0 11 11 11 8 NHL repeat EGF_2 PF07974.13 EFC37998.1 - 1.5e-29 102.0 232.4 0.00013 22.3 10.1 15.1 14 0 0 14 14 14 12 EGF-like domain Arylesterase PF01731.20 EFC37998.1 - 9.3e-07 29.0 9.7 0.39 10.9 0.0 7.1 6 0 0 6 6 6 3 Arylesterase Str_synth PF03088.16 EFC37998.1 - 2.3e-05 24.4 2.1 18 5.6 0.0 7.0 7 0 0 7 7 7 1 Strictosidine synthase SBBP PF06739.11 EFC37998.1 - 0.16 12.0 20.9 0.53 10.3 0.1 6.1 7 0 0 7 7 7 0 Beta-propeller repeat PD40 PF07676.12 EFC37998.1 - 0.31 11.0 4.8 1.1 9.3 0.2 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat REJ PF02010.15 EFC37999.1 - 1.9e-40 139.1 19.4 1.2e-38 133.2 10.4 3.2 1 1 0 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC37999.1 - 0.0012 19.2 27.2 0.0017 18.7 6.5 43.3 42 9 5 47 47 47 17 EGF-like domain LVIVD PF08309.11 EFC37999.1 - 0.038 13.3 2.7 5.3 6.5 0.1 3.0 2 0 0 2 2 2 0 LVIVD repeat Bap31 PF05529.12 EFC38000.1 - 3.2e-10 40.0 6.7 4.7e-10 39.4 6.7 1.4 1 1 0 1 1 1 1 Bap31/Bap29 transmembrane region MFS_2 PF13347.6 EFC38000.1 - 0.025 13.1 2.1 0.032 12.8 2.1 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein ASFV_L11L PF05293.11 EFC38000.1 - 0.031 14.6 2.9 0.04 14.2 2.6 1.4 1 1 0 1 1 1 0 African swine fever virus (ASFV) L11L protein MFS_1 PF07690.16 EFC38000.1 - 0.033 13.1 4.8 0.9 8.4 4.8 2.0 1 1 0 1 1 1 0 Major Facilitator Superfamily Ndc1_Nup PF09531.10 EFC38000.1 - 0.039 12.6 0.4 0.042 12.5 0.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ETRAMP PF09716.10 EFC38000.1 - 0.046 13.8 0.7 0.046 13.8 0.7 2.1 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) YrhC PF14143.6 EFC38000.1 - 0.089 12.9 3.1 0.15 12.2 1.4 2.3 2 1 0 2 2 2 0 YrhC-like protein DUF485 PF04341.12 EFC38000.1 - 0.2 11.6 5.3 0.093 12.7 2.9 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF485 DUF898 PF05987.13 EFC38000.1 - 0.21 10.6 4.1 0.28 10.2 4.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) OAD_gamma PF04277.13 EFC38000.1 - 0.95 10.1 0.0 0.95 10.1 0.0 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF4131 PF13567.6 EFC38000.1 - 2.6 7.6 7.3 3.9 7.1 7.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) EI24 PF07264.11 EFC38000.1 - 3.6 7.8 9.6 25 5.1 9.6 1.9 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Snf7 PF03357.21 EFC38002.1 - 1e-27 96.9 43.5 1.4e-27 96.4 39.0 2.0 1 1 1 2 2 2 1 Snf7 Sulfotransfer_4 PF17784.1 EFC38002.1 - 1 9.1 5.0 8.1 6.2 4.9 2.1 1 1 0 1 1 1 0 Sulfotransferase domain Peptidase_S46 PF10459.9 EFC38002.1 - 1 7.9 20.8 1.2 7.7 20.8 1.0 1 0 0 1 1 1 0 Peptidase S46 hDGE_amylase PF14701.6 EFC38002.1 - 2.1 7.3 11.7 3 6.9 11.7 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF5352 PF17303.2 EFC38002.1 - 2.4 8.0 11.2 0.87 9.4 1.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5352) T2SSF PF00482.23 EFC38002.1 - 3.7 7.5 6.7 3.9 7.5 2.9 2.3 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein F DUF1771 PF08590.10 EFC38003.1 - 3.7e-10 40.0 4.2 7.2e-10 39.1 4.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 EFC38003.1 - 9.8e-10 38.7 0.0 2.3e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Smr domain KH_1 PF00013.29 EFC38003.1 - 5.8e-07 29.2 0.1 1.5e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 KH domain PspA_IM30 PF04012.12 EFC38003.1 - 0.00036 20.2 4.8 0.00071 19.2 4.8 1.5 1 0 0 1 1 1 1 PspA/IM30 family KH_2 PF07650.17 EFC38003.1 - 0.0017 18.2 0.0 0.0017 18.2 0.0 2.5 3 0 0 3 3 3 1 KH domain DUF4834 PF16118.5 EFC38003.1 - 0.17 12.9 0.0 0.17 12.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) PhoU PF01895.19 EFC38003.1 - 0.17 12.4 0.6 0.5 10.9 0.2 2.1 1 1 0 1 1 1 0 PhoU domain DUF2935 PF11155.8 EFC38003.1 - 0.88 9.9 4.9 1.8 8.9 3.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) SMBP PF16785.5 EFC38003.1 - 0.97 9.7 5.3 0.41 10.9 2.1 2.1 2 0 0 2 2 2 0 Small metal-binding protein OmpH PF03938.14 EFC38003.1 - 6.5 7.1 15.9 6.4 7.1 10.8 3.0 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Zn_clus PF00172.18 EFC38004.1 - 0.0027 17.8 2.2 0.0066 16.5 2.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Actin PF00022.19 EFC38005.1 - 2.2e-60 204.4 0.8 1.5e-40 139.1 0.1 2.9 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFC38005.1 - 0.014 14.2 0.0 0.68 8.7 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein SR-25 PF10500.9 EFC38006.1 - 5.4 6.6 13.7 11 5.5 13.7 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Toxin_8 PF07365.12 EFC38007.1 - 0.015 15.5 0.9 0.049 13.8 0.9 1.9 1 0 0 1 1 1 0 Alpha conotoxin precursor Ion_trans PF00520.31 EFC38007.1 - 0.041 13.1 0.0 0.067 12.4 0.0 1.4 1 1 0 1 1 1 0 Ion transport protein G-alpha PF00503.20 EFC38009.1 - 7.6e-13 48.3 4.7 1.2e-11 44.4 4.7 2.5 1 1 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC38009.1 - 0.067 13.3 0.3 0.59 10.2 0.0 2.5 3 0 0 3 3 3 0 50S ribosome-binding GTPase Sel1 PF08238.12 EFC38010.1 - 5e-35 119.2 21.9 1.7e-08 34.9 1.1 7.5 6 1 0 6 6 6 5 Sel1 repeat TPR_6 PF13174.6 EFC38010.1 - 0.053 14.2 5.5 49 4.9 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EFC38010.1 - 0.1 12.7 1.0 23 5.2 0.0 2.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_1 PF00515.28 EFC38010.1 - 0.15 11.9 9.1 8.5 6.4 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38010.1 - 0.57 10.5 7.3 9.7 6.7 0.8 4.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38010.1 - 7 7.0 8.3 20 5.6 0.6 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat FAM76 PF16046.5 EFC38011.1 - 3.6e-05 23.3 2.2 3.6e-05 23.3 2.2 1.5 2 0 0 2 2 2 1 FAM76 protein DUF2353 PF09789.9 EFC38011.1 - 0.00032 20.2 0.9 0.00032 20.2 0.9 2.1 3 0 0 3 3 3 1 Uncharacterized coiled-coil protein (DUF2353) DUF4795 PF16043.5 EFC38011.1 - 0.0054 16.4 2.6 0.0054 16.4 2.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4795) YPEB PF14620.6 EFC38011.1 - 0.009 15.4 4.7 0.012 15.0 3.2 1.8 2 0 0 2 2 2 1 YpeB sporulation SKA2 PF16740.5 EFC38011.1 - 0.015 15.1 4.8 0.055 13.3 4.8 1.9 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DivIC PF04977.15 EFC38011.1 - 0.022 14.5 9.2 0.075 12.8 9.2 1.9 1 0 0 1 1 1 0 Septum formation initiator Interferon PF00143.19 EFC38011.1 - 0.03 14.5 3.8 0.19 11.9 2.5 2.5 2 0 0 2 2 2 0 Interferon alpha/beta domain HemX PF04375.14 EFC38011.1 - 0.033 13.5 3.1 0.062 12.6 3.1 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase KfrA_N PF11740.8 EFC38011.1 - 0.037 14.7 1.7 0.069 13.8 1.7 1.4 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DUF1664 PF07889.12 EFC38011.1 - 0.051 13.6 0.8 0.051 13.6 0.8 2.1 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) DUF4140 PF13600.6 EFC38011.1 - 0.079 13.4 1.7 0.15 12.5 0.9 1.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) APG6_N PF17675.1 EFC38011.1 - 0.3 11.6 19.6 5.4 7.6 15.5 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF3251 PF11622.8 EFC38011.1 - 0.34 10.5 3.1 0.71 9.5 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) CENP-H PF05837.12 EFC38011.1 - 0.65 10.4 11.5 0.18 12.2 6.8 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) USP8_interact PF08941.10 EFC38011.1 - 0.79 9.5 6.2 1.6 8.5 6.2 1.5 1 0 0 1 1 1 0 USP8 interacting Spore_II_R PF09551.10 EFC38011.1 - 1.2 9.5 6.4 10 6.6 0.1 2.5 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) DUF4404 PF14357.6 EFC38011.1 - 1.4 9.6 12.6 0.1 13.2 5.9 2.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4404) MRPL52 PF18699.1 EFC38011.1 - 2.1 8.6 10.9 1.9 8.7 8.2 2.4 2 0 0 2 2 2 0 Mitoribosomal protein mL52 YlqD PF11068.8 EFC38011.1 - 2.3 8.6 17.5 0.11 12.9 10.9 2.1 3 0 0 3 3 2 0 YlqD protein DUF883 PF05957.13 EFC38011.1 - 2.5 8.8 5.1 3.3 8.4 3.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) LMBR1 PF04791.16 EFC38011.1 - 3 6.6 6.7 0.16 10.8 0.4 1.7 1 1 0 1 1 1 0 LMBR1-like membrane protein Occludin_ELL PF07303.13 EFC38011.1 - 4.2 8.2 11.1 1.6 9.5 5.4 2.7 3 0 0 3 3 3 0 Occludin homology domain TMPIT PF07851.13 EFC38011.1 - 4.5 6.4 8.0 0.23 10.7 2.1 1.7 2 0 0 2 2 2 0 TMPIT-like protein bZIP_1 PF00170.21 EFC38011.1 - 4.9 7.3 13.7 0.26 11.4 6.4 2.6 2 1 0 2 2 2 0 bZIP transcription factor Cwf_Cwc_15 PF04889.12 EFC38011.1 - 7.3 6.2 16.5 0.056 13.2 6.1 2.2 3 0 0 3 3 2 0 Cwf15/Cwc15 cell cycle control protein NCD3G PF07562.14 EFC38012.1 - 0.017 15.1 5.1 0.08 12.9 1.3 2.4 1 1 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 EFC38012.1 - 0.66 9.8 13.2 6.3 6.7 12.7 2.4 1 1 0 1 1 1 0 Putative ephrin-receptor like TNFR_c6 PF00020.18 EFC38012.1 - 1 9.8 10.2 39 4.7 10.2 2.5 1 1 0 1 1 1 0 TNFR/NGFR cysteine-rich region IQ PF00612.27 EFC38013.1 - 4.9e-22 75.6 119.6 0.7 9.9 0.7 40.7 48 0 0 48 48 48 20 IQ calmodulin-binding motif Thioredoxin PF00085.20 EFC38014.1 - 9.2e-12 44.9 0.1 1.3e-11 44.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 EFC38014.1 - 0.00077 18.9 0.1 0.0011 18.4 0.1 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HyaE PF07449.11 EFC38014.1 - 0.0014 18.6 0.0 0.0023 17.8 0.0 1.4 1 1 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Phosducin PF02114.16 EFC38014.1 - 0.038 12.9 0.0 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 Phosducin Thioredoxin_2 PF13098.6 EFC38014.1 - 0.14 12.6 0.0 0.2 12.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Ras PF00071.22 EFC38016.1 - 9.3e-14 51.3 0.0 1.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38016.1 - 7.4e-07 29.4 0.0 1.7e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase LEAP-2 PF07359.11 EFC38017.1 - 0.77 9.6 9.4 0.072 12.9 0.9 3.3 2 1 1 3 3 3 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) RUN PF02759.19 EFC38018.1 - 0.39 10.7 5.2 0.35 10.8 1.9 2.8 2 1 0 2 2 2 0 RUN domain COMM_domain PF07258.14 EFC38019.1 - 2.3e-16 59.7 0.0 5.8e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 COMM domain CSN5_C PF18323.1 EFC38019.1 - 0.044 14.7 0.4 0.13 13.2 0.1 1.9 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain RusA PF05866.11 EFC38019.1 - 0.12 12.9 0.3 1.1 9.9 0.1 2.1 2 0 0 2 2 2 0 Endodeoxyribonuclease RusA LRR_4 PF12799.7 EFC38020.1 - 0.053 14.0 6.4 3.6 8.2 0.6 3.7 3 1 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF2536 PF10750.9 EFC38020.1 - 0.071 13.0 0.1 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2536) UvsW PF11637.8 EFC38020.1 - 0.087 12.9 0.3 0.98 9.6 0.1 2.6 2 1 0 2 2 2 0 ATP-dependant DNA helicase UvsW LRR_8 PF13855.6 EFC38020.1 - 0.32 10.8 2.8 6.7 6.6 0.5 3.2 2 1 0 2 2 2 0 Leucine rich repeat EGF_2 PF07974.13 EFC38021.1 - 1.1e-41 140.9 173.9 1.2e-05 25.6 7.5 11.8 11 0 0 11 11 11 11 EGF-like domain NHL PF01436.21 EFC38021.1 - 1.9e-19 68.6 0.3 0.0033 17.4 0.0 7.2 7 0 0 7 7 7 5 NHL repeat EGF PF00008.27 EFC38021.1 - 0.00084 19.6 4.1 0.00084 19.6 4.1 13.2 11 1 1 12 12 12 9 EGF-like domain SGL PF08450.12 EFC38021.1 - 0.0058 16.2 0.4 1.4 8.5 0.0 3.2 2 2 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC38021.1 - 0.017 15.3 0.0 5.1 7.4 0.0 3.9 3 1 1 4 4 4 0 Arylesterase DUF4408 PF14364.6 EFC38021.1 - 0.4 10.5 6.2 0.064 13.0 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4408) Pkinase PF00069.25 EFC38022.1 - 2.9e-52 177.6 6.6 3.2e-35 121.8 0.8 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38022.1 - 2e-26 92.8 0.4 5.5e-19 68.5 0.3 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC38022.1 - 0.00028 19.8 1.4 0.00036 19.4 0.1 1.7 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 EFC38022.1 - 0.016 14.8 1.1 2.5 7.7 0.1 2.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFC38022.1 - 0.024 14.0 0.3 0.1 11.9 0.1 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ERG4_ERG24 PF01222.17 EFC38024.1 - 5.3e-114 381.3 25.3 6.3e-114 381.1 25.3 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Chromate_transp PF02417.15 EFC38024.1 - 0.61 10.2 7.1 0.8 9.8 0.0 2.9 2 1 0 2 2 2 0 Chromate transporter Spore_YhaL PF14147.6 EFC38024.1 - 1.4 8.7 5.9 0.15 11.7 0.6 2.2 2 0 0 2 2 2 0 Sporulation protein YhaL DUF1516 PF07457.11 EFC38024.1 - 2.9 8.1 7.4 0.55 10.5 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) HSP70 PF00012.20 EFC38025.1 - 4.3e-43 147.4 1.5 4.3e-43 147.4 1.5 2.1 3 0 0 3 3 3 1 Hsp70 protein StbA PF06406.11 EFC38025.1 - 2.4e-05 23.7 0.0 0.015 14.6 0.0 3.0 2 1 0 3 3 3 2 StbA protein MreB_Mbl PF06723.13 EFC38025.1 - 6.1e-05 22.0 0.0 0.053 12.3 0.0 3.2 3 0 0 3 3 3 1 MreB/Mbl protein DUF3695 PF12494.8 EFC38025.1 - 0.00018 21.3 1.4 0.00064 19.5 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF3695) DUF1722 PF08349.11 EFC38025.1 - 0.0056 17.0 0.2 0.27 11.5 0.0 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1722) RdgC PF04381.12 EFC38025.1 - 0.012 14.8 0.3 0.022 14.0 0.3 1.4 1 0 0 1 1 1 0 Putative exonuclease, RdgC Spore_GerAC PF05504.11 EFC38025.1 - 0.026 14.7 0.3 0.026 14.7 0.3 3.0 2 0 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal ApoLp-III PF07464.11 EFC38025.1 - 0.044 13.9 0.1 0.044 13.9 0.1 2.6 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Fibrillarin PF01269.17 EFC38026.1 - 0.076 12.1 0.0 3.9 6.5 0.0 3.1 3 0 0 3 3 3 0 Fibrillarin FYVE PF01363.21 EFC38026.1 - 0.097 12.8 38.1 0.32 11.2 8.3 3.6 1 1 2 3 3 3 0 FYVE zinc finger Tnp_zf-ribbon_2 PF13842.6 EFC38026.1 - 0.16 12.8 41.3 0.42 11.5 7.9 3.9 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon Amidase PF01425.21 EFC38026.1 - 0.49 9.3 2.5 0.77 8.7 2.5 1.2 1 0 0 1 1 1 0 Amidase zf-AN1 PF01428.16 EFC38026.1 - 1.4 9.1 38.4 2.2 8.5 7.4 4.0 3 1 0 3 3 3 0 AN1-like Zinc finger Exo_endo_phos PF03372.23 EFC38027.1 - 6.2e-17 61.9 0.0 9.1e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCCH PF00642.24 EFC38027.1 - 0.048 13.6 11.5 3.7 7.6 0.6 4.1 3 0 0 3 3 3 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RdRP PF05183.12 EFC38028.1 - 1.6e-81 274.8 0.1 4.5e-81 273.3 0.0 1.8 2 0 0 2 2 2 1 RNA dependent RNA polymerase Sel1 PF08238.12 EFC38028.1 - 1.7e-34 117.4 10.5 1.7e-07 31.7 0.1 7.9 8 0 0 8 8 8 5 Sel1 repeat TPR_12 PF13424.6 EFC38028.1 - 1.9e-06 28.1 2.0 0.1 12.9 0.2 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38028.1 - 5.1e-05 23.1 20.4 0.013 15.6 0.1 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38028.1 - 0.00023 21.3 3.5 0.0059 16.9 0.1 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC38028.1 - 0.0009 19.8 0.4 0.6 10.8 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38028.1 - 0.0014 18.7 17.0 0.0024 17.9 1.5 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC38028.1 - 0.0015 18.4 4.8 1.2 9.4 0.0 4.0 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38028.1 - 0.004 16.9 19.6 0.0055 16.5 2.9 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC38028.1 - 0.03 15.1 0.6 17 6.5 0.4 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38028.1 - 0.047 13.6 3.0 0.38 10.7 0.2 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC38028.1 - 0.1 12.3 0.1 0.1 12.3 0.1 4.7 6 0 0 6 6 5 0 TPR repeat YlbE PF14003.6 EFC38028.1 - 0.12 12.8 2.4 0.42 11.1 2.4 1.9 1 0 0 1 1 1 0 YlbE-like protein MIT PF04212.18 EFC38028.1 - 0.32 11.1 13.4 1.2 9.2 0.2 6.4 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 EFC38028.1 - 0.75 10.3 3.3 43 4.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PRD PF00874.20 EFC38028.1 - 5 7.5 8.6 19 5.6 0.8 4.4 3 0 0 3 3 3 0 PRD domain TPR_6 PF13174.6 EFC38028.1 - 6.9 7.5 10.0 0.42 11.3 1.7 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat LRR_6 PF13516.6 EFC38029.1 - 1.3e-31 105.9 18.5 0.0018 18.2 0.0 11.2 11 0 0 11 11 11 10 Leucine Rich repeat LRR_8 PF13855.6 EFC38029.1 - 3.4e-25 87.6 12.8 6.2e-07 29.1 0.8 5.2 2 2 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC38029.1 - 6.2e-20 71.0 21.5 5.4e-05 23.5 0.8 6.9 3 1 6 9 9 9 7 Leucine Rich repeats (2 copies) Peptidase_C39_2 PF13529.6 EFC38029.1 - 1.1e-10 42.2 0.0 2e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase_C39 like family LRR_1 PF00560.33 EFC38029.1 - 3.3e-07 29.9 12.1 8.8 7.3 0.0 10.1 12 0 0 12 12 12 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC38029.1 - 6.1e-05 22.6 3.8 0.12 11.9 0.5 2.5 1 1 1 2 2 2 2 Leucine-rich repeat BioY PF02632.14 EFC38030.1 - 1.9e-25 89.5 10.5 1.9e-25 89.5 10.5 1.9 2 0 0 2 2 2 1 BioY family PBECR3 PF18812.1 EFC38030.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.4 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 STIMATE PF12400.8 EFC38030.1 - 1.3 9.5 6.4 3.1 8.3 0.4 2.5 2 1 0 2 2 2 0 STIMATE family RGS PF00615.19 EFC38031.1 - 3e-09 37.2 7.8 3e-09 37.2 7.8 2.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 EFC38031.1 - 2.8e-08 33.7 1.7 5e-07 29.7 0.8 3.0 2 1 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) HSP70 PF00012.20 EFC38032.1 - 7.4e-87 291.9 0.0 1.1e-86 291.3 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC38032.1 - 1.3e-06 27.5 0.0 2.1e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein FAE1_CUT1_RppA PF08392.12 EFC38032.1 - 0.12 11.6 0.1 3.9 6.7 0.0 2.7 3 0 0 3 3 3 0 FAE1/Type III polyketide synthase-like protein TRAM_LAG1_CLN8 PF03798.16 EFC38033.1 - 1.9e-35 122.4 28.6 3.2e-35 121.7 28.6 1.4 1 0 0 1 1 1 1 TLC domain F-box-like PF12937.7 EFC38034.1 - 0.00022 21.0 0.9 0.0046 16.8 0.2 3.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC38034.1 - 0.011 15.7 0.1 0.011 15.7 0.1 3.7 3 0 0 3 3 3 0 F-box domain BTB PF00651.31 EFC38035.1 - 2.1e-10 40.8 0.0 7.4e-10 39.0 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 EFC38035.1 - 0.023 14.8 0.3 0.15 12.2 0.2 2.2 2 0 0 2 2 2 0 BTB And C-terminal Kelch Ribosomal_L6e PF01159.19 EFC38036.1 - 5.4e-34 117.1 0.2 5.4e-34 117.1 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein L6e ZnuA PF01297.17 EFC38038.1 - 0.58 9.5 2.8 7.6 5.8 0.1 2.8 2 1 1 3 3 3 0 Zinc-uptake complex component A periplasmic DUF1043 PF06295.12 EFC38038.1 - 0.61 10.1 11.7 3.7 7.6 2.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) H-kinase_dim PF02895.14 EFC38038.1 - 3.4 8.1 7.0 0.85 10.1 0.6 3.2 3 2 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain DUF3841 PF12952.7 EFC38039.1 - 0.01 15.7 0.0 8.8 6.1 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3841) DUF1007 PF06226.13 EFC38039.1 - 0.053 13.5 0.0 0.27 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1007) CH PF00307.31 EFC38040.1 - 4.4e-25 88.0 11.6 1e-17 64.3 1.6 3.3 3 1 0 3 3 3 2 Calponin homology (CH) domain AAA_13 PF13166.6 EFC38040.1 - 4.8e-06 25.5 27.2 4.8e-06 25.5 27.2 2.2 3 0 0 3 3 3 1 AAA domain CAMSAP_CH PF11971.8 EFC38040.1 - 0.048 13.5 0.0 7.1 6.5 0.0 2.9 2 0 0 2 2 2 0 CAMSAP CH domain RPA_interact_C PF14768.6 EFC38040.1 - 0.093 13.3 1.7 0.37 11.4 1.7 2.1 1 0 0 1 1 1 0 Replication protein A interacting C-terminal DUF3450 PF11932.8 EFC38040.1 - 1.5 8.0 33.6 0.72 9.1 17.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ABC2_membrane_3 PF12698.7 EFC38040.1 - 2.4 7.2 5.4 5.3 6.0 5.4 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF4510 PF14971.6 EFC38040.1 - 2.6 8.4 9.4 0.81 10.0 0.5 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4510) AI-2E_transport PF01594.16 EFC38040.1 - 3 6.9 6.0 0.53 9.4 0.9 2.4 4 0 0 4 4 4 0 AI-2E family transporter DUF3584 PF12128.8 EFC38040.1 - 3.2 5.1 35.4 8.4 3.8 35.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 EFC38040.1 - 9.9 6.6 44.6 0.28 11.6 35.4 2.5 2 1 0 2 2 2 0 Fez1 Baculo_11_kDa PF06143.11 EFC38041.1 - 0.056 13.0 3.4 0.1 12.2 3.4 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family LRR_6 PF13516.6 EFC38042.1 - 4.6e-36 119.8 1.2 0.00028 20.7 0.0 7.1 7 0 0 7 7 7 7 Leucine Rich repeat LRR_8 PF13855.6 EFC38042.1 - 1.3e-34 117.7 8.1 8.2e-10 38.3 0.2 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC38042.1 - 2.6e-21 75.4 0.4 1.4e-05 25.3 0.0 4.2 2 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38042.1 - 1.7e-14 52.1 0.0 5.5 7.9 0.0 7.1 7 0 0 7 7 7 4 Leucine Rich Repeat RHH_3 PF12651.7 EFC38042.1 - 1.2e-13 50.8 0.0 0.029 14.3 0.0 5.9 3 2 3 6 6 6 4 Ribbon-helix-helix domain UPF0193 PF05250.11 EFC38042.1 - 0.017 15.0 2.4 1.9 8.2 0.2 2.6 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0193) LRR_6 PF13516.6 EFC38043.1 - 1.5e-27 93.2 0.6 0.00039 20.2 0.0 6.2 6 0 0 6 6 6 6 Leucine Rich repeat LRR_4 PF12799.7 EFC38043.1 - 1.2e-22 79.6 12.3 0.0001 22.6 0.0 3.8 1 1 4 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38043.1 - 1.1e-19 69.9 0.1 1.3e-08 34.4 0.0 2.6 1 1 0 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFC38043.1 - 4.4e-13 47.8 0.0 3 8.8 0.0 6.4 6 0 0 6 6 6 3 Leucine Rich Repeat RHH_3 PF12651.7 EFC38043.1 - 4.2e-11 42.6 0.0 0.018 15.0 0.0 5.1 2 1 3 5 5 5 4 Ribbon-helix-helix domain LRR_9 PF14580.6 EFC38043.1 - 0.026 14.0 0.0 0.14 11.6 0.0 1.8 1 1 0 1 1 1 0 Leucine-rich repeat UPF0193 PF05250.11 EFC38043.1 - 0.16 11.8 2.0 2.1 8.1 0.2 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0193) Hemerythrin PF01814.23 EFC38044.1 - 2.9e-05 24.7 0.1 5.4e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain Tail_spike_N PF18668.1 EFC38045.1 - 0.045 13.6 0.0 9.5 6.2 0.0 3.1 3 0 0 3 3 3 0 Tail spike TSP1/Gp66 receptor binding N-terminal domain Hydrolase_4 PF12146.8 EFC38046.1 - 6.7e-06 25.5 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 malic PF00390.19 EFC38048.1 - 1.1e-44 152.5 0.0 2e-44 151.6 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain MULE PF10551.9 EFC38049.1 - 0.07 13.6 0.2 0.14 12.5 0.2 1.6 1 0 0 1 1 1 0 MULE transposase domain Cloacin_immun PF03513.14 EFC38050.1 - 0.2 12.0 4.0 2.6 8.4 0.1 3.2 3 0 0 3 3 3 0 Cloacin immunity protein Guanylate_cyc PF00211.20 EFC38051.1 - 3.2e-10 39.9 0.3 6.5e-10 38.9 0.3 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain BTB_2 PF02214.22 EFC38052.1 - 0.0011 19.3 0.3 0.31 11.4 0.1 2.6 1 1 1 2 2 2 2 BTB/POZ domain DUF1681 PF07933.14 EFC38052.1 - 0.039 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) Ank_2 PF12796.7 EFC38053.1 - 1.7e-06 28.5 0.0 1.1e-05 26.0 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC38053.1 - 4.1e-05 23.6 0.0 5.1 8.0 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 EFC38053.1 - 8.4e-05 22.8 0.0 0.16 12.5 0.2 3.5 2 1 0 2 2 2 2 Ankyrin repeat BRAP2 PF07576.12 EFC38053.1 - 0.039 14.2 0.1 0.09 13.0 0.1 1.7 1 0 0 1 1 1 0 BRCA1-associated protein 2 RRM_1 PF00076.22 EFC38053.1 - 0.11 12.3 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUZ PF12752.7 EFC38053.1 - 2.9 8.7 5.3 49 4.8 0.1 2.7 2 0 0 2 2 2 0 SUZ domain GPS PF01825.21 EFC38054.1 - 9.7e-08 32.4 3.5 3.6e-07 30.6 3.5 2.1 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif NHL PF01436.21 EFC38054.1 - 2e-05 24.4 4.6 1.7 8.8 0.0 5.9 7 0 0 7 7 7 3 NHL repeat EGF_2 PF07974.13 EFC38054.1 - 7.4e-05 23.0 27.6 0.011 16.1 8.2 2.8 2 0 0 2 2 2 2 EGF-like domain Alpha-E PF04168.12 EFC38054.1 - 0.0089 15.8 0.1 0.015 15.1 0.1 1.2 1 0 0 1 1 1 1 A predicted alpha-helical domain with a conserved ER motif. EGF PF00008.27 EFC38054.1 - 0.049 13.9 13.5 0.72 10.2 2.8 2.8 2 0 0 2 2 2 0 EGF-like domain DUF2569 PF10754.9 EFC38054.1 - 0.11 13.0 2.4 0.44 11.0 2.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) LapA_dom PF06305.11 EFC38055.1 - 0.019 14.7 0.1 0.038 13.8 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Ank_2 PF12796.7 EFC38057.1 - 3.4e-13 50.0 3.0 1.3e-06 28.9 0.3 2.2 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC38057.1 - 2.1e-08 34.3 0.3 5.9e-07 29.6 0.3 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC38057.1 - 7.8e-05 23.2 0.2 0.001 19.6 0.1 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC38057.1 - 0.00013 22.1 0.3 0.081 13.5 0.1 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 EFC38057.1 - 0.021 15.3 0.1 0.27 11.7 0.1 2.5 3 0 0 3 3 3 0 Ankyrin repeat Vpu PF00558.19 EFC38058.1 - 0.021 14.6 0.3 0.038 13.7 0.3 1.4 1 0 0 1 1 1 0 Vpu protein DUF2701 PF10857.8 EFC38058.1 - 0.062 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) DUF4957 PF16318.5 EFC38059.1 - 0.0044 17.0 2.9 0.026 14.4 0.3 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4957) HEPN_AbiA_CTD PF18732.1 EFC38059.1 - 0.0058 16.6 1.2 0.0058 16.6 1.2 1.8 2 0 0 2 2 2 1 HEPN like, Abia C-terminal domain SapB_1 PF05184.15 EFC38060.1 - 2.4e-27 94.6 33.3 3e-09 36.7 3.2 7.2 7 0 0 7 7 7 5 Saposin-like type B, region 1 SapB_2 PF03489.17 EFC38060.1 - 3.7e-24 84.5 40.5 5.6e-10 39.2 1.0 6.9 6 0 0 6 6 6 5 Saposin-like type B, region 2 SLATT_2 PF18183.1 EFC38060.1 - 0.085 12.6 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 2 DNA_topoisoIV PF00521.20 EFC38062.1 - 0.14 11.0 1.9 0.15 10.9 0.1 1.9 2 1 0 2 2 2 0 DNA gyrase/topoisomerase IV, subunit A EGF_2 PF07974.13 EFC38063.1 - 3.1e-07 30.6 56.4 0.0066 16.8 11.0 4.7 4 0 0 4 4 4 3 EGF-like domain DUF295 PF03478.18 EFC38063.1 - 0.01 15.4 0.6 0.13 11.9 0.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF295) DUF5074 PF16819.5 EFC38063.1 - 0.016 15.2 0.0 0.016 15.2 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF5074) Lipoprotein_X PF03305.13 EFC38063.1 - 0.61 9.8 10.9 0.028 14.2 2.4 2.7 2 0 0 2 2 2 0 Mycoplasma MG185/MG260 protein AAA_14 PF13173.6 EFC38064.1 - 3.5e-07 30.3 2.3 2.6e-05 24.3 0.2 3.4 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFC38064.1 - 6.2e-05 23.3 0.2 0.0015 18.8 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC38064.1 - 0.028 14.8 0.0 0.19 12.1 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFC38064.1 - 0.14 12.7 0.0 0.36 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain RGS PF00615.19 EFC38064.1 - 1.5 9.1 5.7 4.5 7.6 0.1 3.0 3 0 0 3 3 3 0 Regulator of G protein signaling domain Centro_C10orf90 PF17730.1 EFC38065.1 - 0.00033 19.6 0.1 0.00065 18.6 0.1 1.4 1 0 0 1 1 1 1 Centrosomal C10orf90 PRMT5 PF05185.16 EFC38065.1 - 0.092 12.6 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Paramecium_SA PF01508.16 EFC38066.1 - 8.8 6.8 73.6 20 5.7 17.6 4.9 1 1 3 4 4 4 0 Paramecium surface antigen domain GFO_IDH_MocA PF01408.22 EFC38067.1 - 4.5e-10 40.4 0.4 8.7e-10 39.5 0.4 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 EFC38067.1 - 0.00012 22.1 0.0 0.00026 21.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Pox_TAA1 PF03295.14 EFC38067.1 - 0.021 14.7 0.1 0.049 13.5 0.1 1.6 1 0 0 1 1 1 0 Poxvirus trans-activator protein A1 C-terminal RGS PF00615.19 EFC38068.1 - 0.00026 21.2 2.6 0.00026 21.2 2.6 2.7 2 1 0 2 2 2 1 Regulator of G protein signaling domain Borrelia_orfA PF02414.15 EFC38068.1 - 0.046 13.4 3.3 0.11 12.2 3.3 1.6 1 0 0 1 1 1 0 Borrelia ORF-A Exo_endo_phos PF03372.23 EFC38069.1 - 4.8e-08 32.8 0.0 1.3e-07 31.4 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NHL PF01436.21 EFC38070.1 - 1.3e-06 28.1 2.5 0.04 14.0 0.1 4.4 4 0 0 4 4 4 2 NHL repeat Lactonase PF10282.9 EFC38070.1 - 0.00067 19.0 0.0 0.13 11.5 0.0 2.8 3 0 0 3 3 3 2 Lactonase, 7-bladed beta-propeller DUF5128 PF17170.4 EFC38070.1 - 0.00079 18.7 1.7 0.79 8.8 0.0 2.9 2 1 0 2 2 2 2 6-bladed beta-propeller Utp8 PF10395.9 EFC38070.1 - 0.0033 16.0 0.2 0.0042 15.7 0.2 1.2 1 0 0 1 1 1 1 Utp8 family Spore_III_AB PF09548.10 EFC38071.1 - 0.08 13.0 3.2 0.23 11.5 3.2 1.8 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF948 PF06103.11 EFC38071.1 - 0.19 12.0 1.6 0.64 10.3 1.6 2.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) BRE1 PF08647.11 EFC38071.1 - 2.6 8.2 22.0 0.055 13.6 9.5 2.8 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase RCC1_2 PF13540.6 EFC38072.1 - 1e-05 25.2 0.0 2.8 7.8 0.0 4.4 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Inhibitor_I9 PF05922.16 EFC38072.1 - 0.085 13.5 0.0 0.23 12.1 0.0 1.7 1 0 0 1 1 1 0 Peptidase inhibitor I9 RCC1 PF00415.18 EFC38072.1 - 0.18 12.4 1.4 9.5 6.9 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Metallophos_2 PF12850.7 EFC38073.1 - 3.4e-11 43.6 0.0 5.1e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFC38073.1 - 3.3e-05 24.5 2.5 0.0044 17.5 0.6 2.2 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase DDRGK PF09756.9 EFC38074.1 - 6.1e-52 176.0 34.4 6.1e-52 176.0 34.4 2.0 2 0 0 2 2 2 1 DDRGK domain Nop53 PF07767.11 EFC38074.1 - 0.0088 15.5 36.5 0.013 14.9 36.5 1.4 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) FeoC PF09012.10 EFC38074.1 - 0.011 15.8 0.1 0.9 9.7 0.0 2.8 2 0 0 2 2 2 0 FeoC like transcriptional regulator DUF755 PF05501.11 EFC38074.1 - 0.021 15.1 1.5 0.021 15.1 1.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF755) HTH_24 PF13412.6 EFC38074.1 - 0.062 12.9 0.3 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding LRR_4 PF12799.7 EFC38075.1 - 7.2e-07 29.4 40.0 0.078 13.4 2.1 8.8 3 2 7 10 10 10 5 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC38075.1 - 0.00043 20.1 1.1 0.0011 18.8 0.1 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC38075.1 - 0.0016 18.3 0.0 0.0033 17.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like FTH PF01827.27 EFC38075.1 - 0.0078 16.0 19.6 0.27 11.0 0.1 4.4 4 1 0 4 4 4 3 FTH domain LRR_1 PF00560.33 EFC38075.1 - 2.6 8.9 23.7 4.8 8.1 0.4 8.4 8 1 0 8 8 8 0 Leucine Rich Repeat AKAP28 PF14469.6 EFC38076.1 - 0.00012 21.8 0.1 0.00017 21.3 0.1 1.3 1 0 0 1 1 1 1 28 kDa A-kinase anchor DUF4825 PF16107.5 EFC38076.1 - 0.06 13.5 0.1 0.28 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4825) Hep_59 PF07052.11 EFC38077.1 - 1.2e-10 42.1 8.4 1.2e-10 42.1 8.4 2.6 2 0 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 Epimerase PF01370.21 EFC38078.1 - 6.1e-43 147.0 0.4 2.6e-41 141.7 0.0 2.0 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC38078.1 - 5.6e-14 52.3 0.0 1.1e-13 51.3 0.0 1.5 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC38078.1 - 4.6e-06 25.8 0.0 8.3e-06 25.0 0.0 1.4 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFC38078.1 - 9.4e-06 25.0 0.3 0.00094 18.4 0.0 3.0 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Zn_clus PF00172.18 EFC38080.1 - 0.0028 17.8 11.8 0.007 16.5 11.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KIAA1430 PF13879.6 EFC38080.1 - 0.034 14.9 1.3 0.089 13.6 0.1 2.3 2 0 0 2 2 2 0 KIAA1430 homologue DUF2379 PF09543.10 EFC38080.1 - 0.16 12.1 0.0 3.3 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) DUF4116 PF13475.6 EFC38082.1 - 5.2e-68 224.6 15.0 4.5e-16 58.3 0.0 7.8 4 2 5 9 9 9 9 Domain of unknown function (DUF4116) DUF3107 PF11305.8 EFC38082.1 - 0.048 13.9 1.6 6 7.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3107) DUF1611_N PF17396.2 EFC38082.1 - 0.13 12.5 0.3 8.3 6.7 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1611_N) Rossmann-like domain DUF1154 PF06631.11 EFC38082.1 - 2.4 8.3 8.9 0.15 12.1 1.3 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1154) Guanylate_cyc PF00211.20 EFC38083.1 - 1.9e-51 174.3 0.0 5.2e-51 172.9 0.0 1.8 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38083.1 - 1.8e-13 50.6 0.2 9.4e-13 48.3 0.1 2.4 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC38083.1 - 3.9e-07 30.1 0.0 1.1e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC38083.1 - 0.0016 18.4 0.0 0.005 16.8 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC38083.1 - 0.011 16.0 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC38083.1 - 0.11 11.9 0.1 0.28 10.6 0.1 1.7 1 0 0 1 1 1 0 Heme NO binding associated GATA PF00320.27 EFC38084.1 - 1.9e-10 40.1 5.5 7.5e-10 38.2 5.5 2.1 1 0 0 1 1 1 1 GATA zinc finger PHD PF00628.29 EFC38084.1 - 6.9e-06 25.9 12.3 6.9e-06 25.9 12.3 2.9 2 1 0 3 3 3 1 PHD-finger C1_1 PF00130.22 EFC38084.1 - 0.00015 21.6 3.8 0.00015 21.6 3.8 2.6 1 1 1 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) NAPRTase_C PF17956.1 EFC38084.1 - 0.04 14.4 0.1 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain PHD_2 PF13831.6 EFC38084.1 - 2.1 8.0 9.5 2.5 7.7 6.6 2.6 2 0 0 2 2 2 0 PHD-finger DUF4116 PF13475.6 EFC38085.1 - 4.7e-75 247.1 21.7 1.9e-17 62.7 0.0 9.6 4 2 6 11 11 11 11 Domain of unknown function (DUF4116) UPF0223 PF05256.12 EFC38085.1 - 0.025 14.9 0.2 0.074 13.4 0.2 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0223) POTRA PF07244.15 EFC38085.1 - 0.11 13.1 0.1 0.43 11.2 0.1 2.1 1 0 0 1 1 1 0 Surface antigen variable number repeat Glyco_transf_10 PF00852.19 EFC38086.1 - 5.3e-26 91.4 0.0 1e-25 90.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term CotJB PF12652.7 EFC38086.1 - 2.7 8.3 5.3 12 6.2 0.3 3.2 3 0 0 3 3 3 0 CotJB protein Trypsin PF00089.26 EFC38088.1 - 5.7e-37 127.7 3.6 8e-37 127.2 3.6 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC38088.1 - 0.0099 16.8 0.3 0.017 16.0 0.3 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1643 PF07799.12 EFC38088.1 - 0.13 12.4 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) Mid2 PF04478.12 EFC38089.1 - 0.023 14.6 0.2 0.06 13.2 0.2 1.7 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor SCIMP PF15050.6 EFC38089.1 - 0.088 13.3 4.1 4.8 7.7 0.0 3.3 3 0 0 3 3 3 0 SCIMP protein CYYR1 PF10873.8 EFC38090.1 - 0.0037 17.7 0.3 0.011 16.2 0.3 1.7 1 0 0 1 1 1 1 Cysteine and tyrosine-rich protein 1 DUF4131 PF13567.6 EFC38090.1 - 0.061 13.0 0.2 1.3 8.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) FtsK_4TM PF13491.6 EFC38090.1 - 0.078 12.7 0.2 0.078 12.7 0.2 2.2 2 1 0 2 2 2 0 4TM region of DNA translocase FtsK/SpoIIIE TMEM52 PF14979.6 EFC38090.1 - 2.1 8.2 7.3 0.14 12.1 0.3 2.2 2 0 0 2 2 2 0 Transmembrane 52 Exostosin PF03016.15 EFC38091.1 - 1e-17 64.3 2.7 1.7e-15 57.0 0.7 2.9 2 1 0 2 2 2 2 Exostosin family Fz PF01392.22 EFC38092.1 - 6.4e-07 30.0 2.6 1.9e-06 28.4 2.6 1.8 1 0 0 1 1 1 1 Fz domain FA_desaturase PF00487.24 EFC38093.1 - 5.1e-18 65.8 18.3 5.8e-18 65.7 17.3 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Pyr_redox_2 PF07992.14 EFC38094.1 - 2.2e-27 96.1 0.0 2.9e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC38094.1 - 3.3e-08 34.0 0.0 6.7e-05 23.4 0.0 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC38094.1 - 6.9e-06 25.5 0.0 0.0033 16.7 0.0 2.4 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC38094.1 - 0.0001 21.5 0.0 0.00065 19.0 0.0 2.0 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 EFC38094.1 - 0.00079 19.6 0.0 0.0025 18.0 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC38094.1 - 0.0045 16.6 5.8 0.046 13.3 0.0 2.8 2 1 1 3 3 3 1 FAD dependent oxidoreductase ApbA PF02558.16 EFC38094.1 - 0.0092 15.6 0.0 0.2 11.3 0.0 2.8 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 EFC38094.1 - 0.015 14.1 0.7 0.31 9.7 0.0 3.2 4 1 0 4 4 4 0 HI0933-like protein Lycopene_cycl PF05834.12 EFC38094.1 - 0.083 11.9 0.0 7.5 5.5 0.0 2.4 2 1 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 EFC38094.1 - 0.1 11.5 0.0 0.46 9.3 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.22 EFC38094.1 - 0.11 11.6 0.0 7.3 5.6 0.0 2.5 2 0 0 2 2 2 0 Glucose inhibited division protein A TrkA_N PF02254.18 EFC38094.1 - 0.13 12.5 0.0 3.6 7.9 0.0 2.7 2 0 0 2 2 2 0 TrkA-N domain Glyco_transf_10 PF00852.19 EFC38095.1 - 1.8e-26 93.0 0.0 4.2e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Aspzincin_M35 PF14521.6 EFC38095.1 - 0.0031 18.1 0.7 0.27 11.8 0.0 2.9 3 0 0 3 3 3 1 Lysine-specific metallo-endopeptidase ABC2_membrane_3 PF12698.7 EFC38095.1 - 0.11 11.6 0.2 0.16 11.1 0.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3562 PF12085.8 EFC38095.1 - 0.17 11.5 0.0 1.4 8.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3562) FRG1 PF06229.12 EFC38096.1 - 4.2e-31 108.1 0.0 3.9e-09 36.5 0.0 5.1 1 1 4 5 5 5 5 FRG1-like domain Fascin PF06268.13 EFC38096.1 - 2.9e-26 91.9 0.0 1.6e-08 34.7 0.0 4.0 1 1 3 4 4 4 4 Fascin domain FGF PF00167.18 EFC38096.1 - 2.7e-05 24.3 0.0 0.11 12.6 0.0 2.7 1 1 2 3 3 3 2 Fibroblast growth factor Ribosomal_L37ae PF01780.19 EFC38096.1 - 0.035 14.2 0.0 2.6 8.2 0.0 3.4 3 2 0 4 4 4 0 Ribosomal L37ae protein family BRCA2 PF00634.18 EFC38096.1 - 0.22 11.3 0.9 97 2.8 0.0 3.6 5 0 0 5 5 5 0 BRCA2 repeat Exostosin PF03016.15 EFC38097.1 - 5.3e-08 32.4 1.6 1.7e-07 30.8 1.6 1.8 1 1 0 1 1 1 1 Exostosin family Gal_GalNac_35kD PF17337.2 EFC38097.1 - 0.00065 19.8 0.8 0.002 18.2 0.0 2.1 2 1 0 2 2 2 1 Galactose-inhibitable lectin 35 kDa subunit Zn_clus PF00172.18 EFC38098.1 - 3.6e-06 27.0 11.2 6.2e-06 26.2 11.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Bin3 PF06859.12 EFC38098.1 - 1.2 9.8 4.3 0.61 10.7 0.9 2.2 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) zf-C4pol PF14260.6 EFC38099.1 - 0.38 11.3 4.9 14 6.2 0.6 2.6 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta DUF4811 PF16069.5 EFC38099.1 - 0.84 9.5 12.6 2.5 7.9 6.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) Mitofilin PF09731.9 EFC38099.1 - 1.9 7.2 5.8 0.48 9.2 2.5 1.6 2 0 0 2 2 2 0 Mitochondrial inner membrane protein SR-25 PF10500.9 EFC38100.1 - 0.18 11.4 9.9 0.28 10.7 9.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Noggin PF05806.12 EFC38100.1 - 1.2 9.0 6.8 2.8 7.8 0.1 2.1 1 1 1 2 2 2 0 Noggin SR-25 PF10500.9 EFC38101.1 - 0.011 15.4 10.1 0.019 14.6 10.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein VWA_2 PF13519.6 EFC38103.1 - 1.5e-11 44.9 0.0 3.2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC38103.1 - 2.8e-09 37.5 0.0 5.1e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain TssR PF17643.1 EFC38103.1 - 0.05 11.5 0.0 0.076 11.0 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssR VWA_3 PF13768.6 EFC38103.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF4761 PF15958.5 EFC38104.1 - 0.083 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4761) TMEM52 PF14979.6 EFC38105.1 - 0.094 12.6 0.3 8.8 6.2 0.1 2.5 2 0 0 2 2 2 0 Transmembrane 52 GST_C PF00043.25 EFC38106.1 - 1.4e-12 47.7 0.0 1.8e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC38106.1 - 4.3e-12 46.1 0.0 4.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC38106.1 - 6e-11 42.2 0.0 7.4e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 EFC38106.1 - 0.007 16.1 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 EFC38106.1 - 0.11 13.1 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.13 EFC38106.1 - 0.16 11.8 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_N PF02798.20 EFC38107.1 - 1.8e-18 66.6 0.0 2.4e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC38107.1 - 5.2e-15 55.6 0.0 6.3e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC38107.1 - 4.1e-14 52.6 0.0 5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain PSII_Pbs31 PF18240.1 EFC38107.1 - 0.11 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Photosystem II Psb31 protein TPR_1 PF00515.28 EFC38108.1 - 5.6e-28 95.6 2.3 4.4e-05 23.1 0.0 6.5 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38108.1 - 1.4e-21 74.8 0.3 0.018 15.1 0.0 7.1 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFC38108.1 - 6.4e-16 57.8 5.3 8.4e-05 22.2 0.0 6.1 5 1 1 6 6 6 4 TPR repeat TPR_8 PF13181.6 EFC38108.1 - 2e-12 46.3 6.8 0.11 12.7 0.1 7.0 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38108.1 - 4.2e-11 42.7 0.1 3.1 8.6 0.0 6.8 6 1 2 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38108.1 - 5.7e-09 35.8 3.5 0.009 16.3 0.0 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC38108.1 - 1.3e-07 31.6 0.0 0.015 15.4 0.0 4.2 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC38108.1 - 0.0003 21.4 0.0 0.11 13.1 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38108.1 - 0.00032 20.9 0.5 13 6.2 0.1 4.8 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC38108.1 - 0.00053 19.8 1.4 0.08 13.0 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC38108.1 - 0.17 12.0 2.8 18 5.5 0.0 3.8 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat GAGA_bind PF06217.12 EFC38108.1 - 0.69 10.1 5.0 1.1 9.5 5.0 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 EFC38108.1 - 8 5.1 10.3 11 4.7 10.3 1.1 1 0 0 1 1 1 0 Presenilin NOT2_3_5 PF04153.18 EFC38109.1 - 0.32 11.1 3.4 9.7 6.3 2.2 2.3 2 0 0 2 2 2 0 NOT2 / NOT3 / NOT5 family DUF2614 PF11023.8 EFC38109.1 - 4 7.6 7.0 0.25 11.5 0.4 2.2 3 0 0 3 3 3 0 Zinc-ribbon containing domain Pkinase PF00069.25 EFC38110.1 - 1.1e-67 228.2 0.0 2.1e-67 227.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38110.1 - 2.5e-42 145.0 0.0 4.5e-42 144.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC38110.1 - 9e-07 28.5 0.0 4.1e-06 26.3 0.0 2.1 2 0 0 2 2 2 1 Kinase-like DUF3782 PF12644.7 EFC38110.1 - 0.032 14.4 0.0 0.12 12.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) YrbL-PhoP_reg PF10707.9 EFC38110.1 - 0.052 13.1 0.1 0.13 11.7 0.1 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL LRR_6 PF13516.6 EFC38111.1 - 6e-41 135.0 23.5 8e-06 25.5 0.2 11.0 11 0 0 11 11 11 9 Leucine Rich repeat LRR_8 PF13855.6 EFC38111.1 - 3.8e-32 109.8 34.8 1.2e-07 31.4 4.3 5.1 2 2 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC38111.1 - 1.8e-20 72.7 27.7 0.00013 22.3 2.4 6.8 1 1 7 9 9 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38111.1 - 3.9e-11 41.9 17.0 3.7 8.5 0.0 9.9 10 1 0 10 10 10 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC38111.1 - 1.5e-05 24.5 1.2 1 8.9 0.3 3.2 1 1 2 3 3 3 3 Leucine-rich repeat GGGtGRT PF14057.6 EFC38111.1 - 0.077 11.9 0.1 0.44 9.5 0.0 2.0 1 1 1 2 2 2 0 GGGtGRT protein DUF563 PF04577.14 EFC38113.1 - 1.7e-24 87.1 0.2 2.9e-24 86.4 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF563) Pyr_redox_2 PF07992.14 EFC38114.1 - 1.8e-36 125.9 0.0 3e-36 125.2 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC38114.1 - 1.1e-09 38.7 3.8 1.1e-06 29.1 0.1 3.4 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC38114.1 - 7.7e-08 32.5 0.0 0.0013 18.8 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 EFC38114.1 - 2.2e-07 30.8 0.0 0.002 17.8 0.0 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFC38114.1 - 0.00096 18.5 9.4 3.4 6.8 0.0 4.1 2 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC38114.1 - 0.0015 18.7 0.1 0.055 13.7 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFC38114.1 - 0.0077 15.3 0.0 0.72 8.8 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EFC38114.1 - 0.022 13.6 0.4 0.12 11.2 0.1 2.1 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_3 PF01494.19 EFC38114.1 - 0.024 13.9 0.0 5.6 6.1 0.0 2.8 3 0 0 3 3 3 0 FAD binding domain Thi4 PF01946.17 EFC38114.1 - 0.036 13.3 0.0 0.54 9.4 0.0 2.2 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.21 EFC38114.1 - 0.043 13.1 0.1 0.5 9.6 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 EFC38114.1 - 0.13 12.5 0.2 20 5.5 0.0 2.6 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 EFC38114.1 - 0.23 11.9 0.6 28 5.2 0.1 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding EGF_2 PF07974.13 EFC38115.1 - 3.5e-20 72.1 70.7 2.7e-05 24.4 7.9 5.5 5 0 0 5 5 5 5 EGF-like domain RGS PF00615.19 EFC38115.1 - 3.7e-09 36.9 0.9 1.1e-08 35.4 0.9 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain EGF PF00008.27 EFC38115.1 - 0.093 13.1 67.0 0.083 13.2 6.5 6.2 6 0 0 6 6 6 0 EGF-like domain MPP6 PF10175.9 EFC38115.1 - 2.6 8.5 6.4 26 5.3 0.4 3.0 2 1 0 2 2 2 0 M-phase phosphoprotein 6 EGF_2 PF07974.13 EFC38116.1 - 3.9e-23 81.5 132.1 0.00013 22.3 9.8 9.1 9 0 0 9 9 9 8 EGF-like domain B_lectin PF01453.24 EFC38116.1 - 0.007 16.9 0.0 5.4 7.6 0.0 2.3 1 1 1 2 2 2 2 D-mannose binding lectin GNAT_acetyltran PF12746.7 EFC38117.1 - 0.082 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase HHV-5_US34A PF17087.5 EFC38117.1 - 0.13 12.5 0.8 2.4 8.4 0.1 2.4 2 0 0 2 2 2 0 Herpesvirus US34A protein family Mid2 PF04478.12 EFC38117.1 - 0.68 9.7 6.4 0.24 11.2 0.6 2.5 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor DUF4003 PF13170.6 EFC38120.1 - 0.007 15.8 1.5 0.011 15.1 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4003) Guanylate_cyc PF00211.20 EFC38121.1 - 4.3e-53 179.7 0.0 8.4e-53 178.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38121.1 - 7.5e-18 64.7 0.5 8.4e-17 61.3 0.1 2.8 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC38121.1 - 1.4e-11 44.3 0.0 6.8e-11 42.2 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC38121.1 - 8.6e-07 28.8 0.0 0.00019 21.4 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EFC38121.1 - 0.0012 19.1 0.0 0.0022 18.2 0.0 1.4 1 0 0 1 1 1 1 PAS fold Rap_GAP PF02145.15 EFC38122.1 - 8e-52 175.5 0.1 1.9e-51 174.3 0.1 1.7 1 0 0 1 1 1 1 Rap/ran-GAP DUF1722 PF08349.11 EFC38122.1 - 0.019 15.2 0.2 0.095 13.0 0.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) Pkinase PF00069.25 EFC38123.1 - 8.3e-45 153.2 2.8 6.1e-40 137.2 0.4 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38123.1 - 4.8e-25 88.3 0.9 1.2e-22 80.4 0.1 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC38123.1 - 5.2e-05 22.3 0.3 5.2e-05 22.3 0.3 2.9 2 1 1 3 3 3 1 Haspin like kinase domain Kinase-like PF14531.6 EFC38123.1 - 0.0001 21.8 0.0 0.00021 20.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC38123.1 - 0.032 14.2 0.5 0.05 13.5 0.5 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M16 PF00675.20 EFC38123.1 - 0.1 12.6 0.5 0.24 11.3 0.5 1.6 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) RIO1 PF01163.22 EFC38123.1 - 0.19 11.3 4.0 0.066 12.8 0.4 2.0 2 0 0 2 2 2 0 RIO1 family NAD_binding_2 PF03446.15 EFC38124.1 - 1.8e-42 145.2 0.6 2.9e-42 144.5 0.6 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 EFC38124.1 - 1e-33 116.2 0.1 1.6e-33 115.5 0.1 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 EFC38124.1 - 1.1e-07 32.3 0.1 2.5e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EFC38124.1 - 1.2e-06 28.7 0.0 2.3e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFC38124.1 - 2.2e-05 23.9 0.0 4e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFC38124.1 - 0.0052 16.1 0.3 0.0097 15.2 0.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 EFC38124.1 - 0.0091 15.9 0.1 0.015 15.2 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Folate_rec PF03024.14 EFC38125.1 - 2.1e-07 31.0 10.0 6.2e-07 29.4 7.5 2.4 1 1 1 2 2 2 1 Folate receptor family Oxidored_FMN PF00724.20 EFC38127.1 - 1.1e-88 297.9 0.0 1.2e-88 297.6 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF4021 PF13213.6 EFC38127.1 - 0.00087 19.2 0.5 0.0022 17.9 0.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4021) Pkinase PF00069.25 EFC38128.1 - 4.2e-55 187.0 2.0 6e-55 186.4 2.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38128.1 - 3.6e-37 128.1 0.1 1.2e-36 126.4 0.3 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase NHL PF01436.21 EFC38128.1 - 7.2e-17 60.5 0.1 0.00025 20.9 0.0 6.2 5 0 0 5 5 5 3 NHL repeat Pkinase_fungal PF17667.1 EFC38128.1 - 4.3e-06 25.8 0.0 8.4e-06 24.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase SGL PF08450.12 EFC38128.1 - 0.0005 19.7 1.7 0.15 11.6 1.3 3.6 3 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region YrbL-PhoP_reg PF10707.9 EFC38128.1 - 0.01 15.4 0.1 0.025 14.1 0.1 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.14 EFC38128.1 - 0.11 11.8 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFC38129.1 - 1.8e-43 148.8 0.0 2.6e-43 148.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38129.1 - 1.4e-24 86.8 0.0 2e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC38129.1 - 8e-16 58.1 130.3 9.1e-05 22.7 4.5 9.5 9 0 0 9 9 9 6 EGF-like domain NHL PF01436.21 EFC38129.1 - 6.4e-15 54.3 3.0 0.00087 19.2 0.0 8.3 8 0 0 8 8 8 3 NHL repeat Kdo PF06293.14 EFC38129.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family EGF PF00008.27 EFC38129.1 - 0.0028 17.9 15.4 0.0032 17.7 4.4 8.5 9 0 0 9 9 9 4 EGF-like domain DUF4536 PF15055.6 EFC38129.1 - 0.055 13.7 0.0 0.15 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) PQQ_2 PF13360.6 EFC38129.1 - 0.2 11.2 0.3 20 4.6 0.0 3.1 3 0 0 3 3 3 0 PQQ-like domain APO_RNA-bind PF05634.11 EFC38130.1 - 0.048 13.0 0.9 0.063 12.6 0.9 1.2 1 0 0 1 1 1 0 APO RNA-binding Tubulin PF00091.25 EFC38131.1 - 7.2e-67 225.4 0.0 1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC38131.1 - 1.4e-49 167.5 0.1 2.3e-49 166.8 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC38131.1 - 0.0086 15.8 0.0 0.024 14.3 0.0 1.8 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 EFC38131.1 - 0.23 10.6 0.3 0.39 9.9 0.3 1.2 1 0 0 1 1 1 0 Tubulin like DUF4116 PF13475.6 EFC38132.1 - 5e-13 48.6 23.2 0.006 16.3 0.0 9.1 7 2 1 8 8 8 7 Domain of unknown function (DUF4116) DUF3658 PF12395.8 EFC38132.1 - 0.0041 17.0 0.1 2.3 8.2 0.0 4.0 5 0 0 5 5 5 1 Protein of unknown function Abhydrolase_1 PF00561.20 EFC38133.1 - 8.1e-05 22.4 1.4 0.00029 20.6 0.6 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EFC38133.1 - 0.019 14.5 0.4 0.033 13.7 0.4 1.4 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Ndr PF03096.14 EFC38133.1 - 0.02 13.6 0.2 0.049 12.3 0.2 1.7 1 1 0 1 1 1 0 Ndr family Hydrolase_4 PF12146.8 EFC38133.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Utp8 PF10395.9 EFC38134.1 - 0.0028 16.3 0.3 0.02 13.4 0.1 1.9 1 1 1 2 2 2 1 Utp8 family NHL PF01436.21 EFC38134.1 - 0.021 14.9 0.2 0.81 9.8 0.0 2.8 3 0 0 3 3 3 0 NHL repeat PQQ PF01011.21 EFC38134.1 - 0.047 13.6 0.8 7.9 6.6 0.0 3.1 3 0 0 3 3 3 0 PQQ enzyme repeat PseudoU_synth_2 PF00849.22 EFC38135.1 - 3.4e-22 79.2 0.0 1.3e-21 77.3 0.0 2.0 2 0 0 2 2 2 1 RNA pseudouridylate synthase zf-RING_2 PF13639.6 EFC38136.1 - 8.2e-10 38.9 11.4 1.3e-09 38.3 11.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFC38136.1 - 5.4e-07 29.8 11.0 1.4e-06 28.5 11.0 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFC38136.1 - 2e-06 27.7 10.5 3.2e-06 27.0 10.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFC38136.1 - 2.3e-06 27.3 10.8 4e-06 26.6 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC38136.1 - 8.3e-06 25.7 8.0 1.6e-05 24.8 8.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC38136.1 - 7.1e-05 22.6 10.5 0.00015 21.5 10.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC38136.1 - 0.00016 21.3 11.0 0.00031 20.4 11.0 1.5 1 0 0 1 1 1 1 RING-like zinc finger Prok-RING_4 PF14447.6 EFC38136.1 - 0.00045 20.0 7.7 0.0016 18.2 7.8 1.8 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 EFC38136.1 - 0.00083 19.2 8.3 0.0013 18.5 8.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFC38136.1 - 0.00099 19.2 6.2 0.0021 18.1 6.2 1.6 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 EFC38136.1 - 0.0021 18.1 6.1 0.014 15.5 6.1 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFC38136.1 - 0.028 14.2 6.3 0.054 13.3 6.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 EFC38136.1 - 0.038 14.2 10.3 0.27 11.5 10.3 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-HC5HC2H_2 PF13832.6 EFC38136.1 - 0.1 12.8 4.9 0.21 11.8 4.9 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 EFC38136.1 - 0.17 12.2 7.6 0.4 11.0 7.6 1.6 1 1 0 1 1 1 0 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 EFC38136.1 - 0.32 10.6 9.2 0.63 9.7 9.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 EFC38136.1 - 0.87 9.8 10.5 1.5 9.0 10.5 1.4 1 0 0 1 1 1 0 RING-variant domain zf-Di19 PF05605.12 EFC38136.1 - 1.8 8.9 8.9 1.1 9.6 0.3 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-RING-like PF08746.11 EFC38136.1 - 5.3 7.4 10.1 9.9 6.6 10.1 1.5 1 0 0 1 1 1 0 RING-like domain Pkinase PF00069.25 EFC38137.1 - 3.5e-61 206.9 0.0 4.9e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38137.1 - 1.5e-37 129.3 0.0 2e-37 128.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC38137.1 - 6.5e-06 25.7 0.1 0.00024 20.5 0.1 2.7 2 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC38137.1 - 0.0026 16.8 1.2 0.0085 15.1 0.0 2.3 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFC38137.1 - 0.0031 17.5 0.0 0.0079 16.1 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC38137.1 - 0.0054 15.6 0.0 0.0089 14.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC38137.1 - 0.011 15.1 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFC38137.1 - 0.017 14.7 1.6 0.9 9.1 0.0 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 EFC38137.1 - 0.052 13.2 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family RNA_lig_T4_1 PF09511.10 EFC38139.1 - 1.1e-26 94.0 0.9 3.2e-25 89.3 0.2 2.6 2 1 0 2 2 2 1 RNA ligase GnsAB_toxin PF08178.11 EFC38139.1 - 0.038 13.9 0.6 0.11 12.4 0.6 1.8 1 0 0 1 1 1 0 GnsA/GnsB toxin of bacterial toxin-antitoxin system F-box-like PF12937.7 EFC38140.1 - 0.1 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 F-box-like DUF1771 PF08590.10 EFC38141.1 - 1.8e-16 60.2 1.5 4.1e-16 59.1 1.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) KH_1 PF00013.29 EFC38141.1 - 1e-09 38.1 0.0 1.9e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 KH domain Smr PF01713.21 EFC38141.1 - 9.4e-09 35.5 0.0 2.4e-08 34.2 0.0 1.7 2 0 0 2 2 2 1 Smr domain KH_2 PF07650.17 EFC38141.1 - 0.022 14.6 0.1 0.099 12.5 0.0 2.2 2 0 0 2 2 2 0 KH domain AJAP1_PANP_C PF15298.6 EFC38141.1 - 0.068 13.4 10.9 0.11 12.7 10.9 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF4250 PF14056.6 EFC38141.1 - 0.13 12.2 0.3 0.49 10.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) DUF2379 PF09543.10 EFC38141.1 - 0.26 11.5 0.1 0.26 11.5 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2379) MIG-14_Wnt-bd PF06664.12 EFC38142.1 - 5.2e-58 196.6 30.8 6.3e-58 196.3 26.6 2.0 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF3382 PF11862.8 EFC38142.1 - 0.022 15.0 4.8 0.69 10.2 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3382) DUF2140 PF09911.9 EFC38142.1 - 0.065 12.8 0.2 1.6 8.2 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) FtsH_ext PF06480.15 EFC38142.1 - 0.95 9.8 6.0 0.54 10.6 1.2 3.0 3 0 0 3 3 3 0 FtsH Extracellular DUF21 PF01595.20 EFC38143.1 - 7.2e-28 97.5 0.2 1.5e-27 96.4 0.2 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EFC38143.1 - 2.3e-08 34.4 0.1 0.0015 18.9 0.0 2.8 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 EFC38143.1 - 6.2e-06 26.2 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DC_STAMP PF07782.13 EFC38143.1 - 0.098 12.5 0.2 0.39 10.5 0.0 2.2 2 0 0 2 2 2 0 DC-STAMP-like protein LRR_4 PF12799.7 EFC38144.1 - 1.8 9.1 19.5 6 7.4 0.9 6.0 3 3 0 4 4 4 0 Leucine Rich repeats (2 copies) GTP_EFTU PF00009.27 EFC38145.1 - 4.6e-22 78.5 0.0 6.5e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC38145.1 - 1.1e-15 57.9 0.0 5.8e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC38145.1 - 0.00053 20.3 0.1 0.0024 18.2 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 G-alpha PF00503.20 EFC38145.1 - 0.024 13.8 0.1 0.034 13.3 0.1 1.3 1 0 0 1 1 1 0 G-protein alpha subunit SRPRB PF09439.10 EFC38145.1 - 0.032 13.6 0.3 0.18 11.2 0.3 2.1 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NTPase_1 PF03266.15 EFC38145.1 - 0.033 14.1 0.1 0.11 12.4 0.1 1.9 1 1 0 1 1 1 0 NTPase MMR_HSR1 PF01926.23 EFC38145.1 - 0.04 14.0 0.1 0.14 12.2 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 EFC38145.1 - 0.14 12.8 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PARM PF17061.5 EFC38146.1 - 5.9 7.0 24.7 1.2 9.2 17.7 2.1 2 0 0 2 2 2 0 PARM DASH_Dad4 PF08650.10 EFC38146.1 - 7.2 6.7 6.1 7.3 6.6 0.3 3.3 3 1 0 3 3 3 0 DASH complex subunit Dad4 DUF4116 PF13475.6 EFC38147.1 - 2.8e-68 225.5 12.8 8.9e-17 60.6 0.0 7.6 4 2 5 9 9 9 8 Domain of unknown function (DUF4116) DUF3107 PF11305.8 EFC38147.1 - 0.25 11.6 1.3 39 4.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3107) DUF1154 PF06631.11 EFC38147.1 - 0.31 11.1 5.8 0.16 12.0 1.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1154) DUF3134 PF11332.8 EFC38149.1 - 7.2 7.0 10.9 0.13 12.6 1.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3134) SR-25 PF10500.9 EFC38150.1 - 0.017 14.7 11.5 0.033 13.8 11.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pre-SET PF05033.16 EFC38153.1 - 0.00035 21.2 6.8 0.0006 20.4 6.8 1.3 1 0 0 1 1 1 1 Pre-SET motif SH3_1 PF00018.28 EFC38156.1 - 1.3e-15 56.7 0.1 2.4e-15 55.9 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFC38156.1 - 1.6e-11 43.9 0.0 2.7e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFC38156.1 - 3.2e-11 42.7 0.0 5.4e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 EFC38156.1 - 1.9e-07 31.1 1.4 1.9e-07 31.1 1.4 2.8 2 1 1 3 3 3 2 BAR domain of APPL family Arfaptin PF06456.13 EFC38156.1 - 0.00095 18.8 0.5 0.0019 17.8 0.0 1.7 2 0 0 2 2 2 1 Arfaptin-like domain BAR PF03114.18 EFC38156.1 - 0.02 14.6 0.1 0.02 14.6 0.1 2.0 2 0 0 2 2 2 0 BAR domain RCC1 PF00415.18 EFC38157.1 - 3.8e-14 53.1 0.4 0.07 13.8 0.0 6.3 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC38157.1 - 7.2e-07 28.9 10.7 0.00024 20.8 0.5 5.7 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Treacle PF03546.14 EFC38157.1 - 0.11 11.3 0.4 0.15 10.8 0.4 1.1 1 0 0 1 1 1 0 Treacher Collins syndrome protein Treacle DUF1343 PF07075.11 EFC38158.1 - 9.2e-104 347.6 0.0 1.1e-103 347.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1343) GDP_Man_Dehyd PF16363.5 EFC38159.1 - 6.1e-155 515.6 0.0 6.9e-155 515.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC38159.1 - 9.1e-71 238.1 0.0 1.1e-70 237.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFC38159.1 - 0.00062 19.0 0.0 0.0009 18.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFC38159.1 - 0.012 14.7 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFC38159.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding IMCp PF12314.8 EFC38160.1 - 0.00044 20.5 4.5 0.00085 19.6 4.5 1.5 1 0 0 1 1 1 1 Inner membrane complex protein FtsH_ext PF06480.15 EFC38160.1 - 0.024 15.0 0.2 0.082 13.3 0.2 1.9 1 1 0 1 1 1 0 FtsH Extracellular Gti1_Pac2 PF09729.9 EFC38160.1 - 0.065 13.3 0.6 0.11 12.6 0.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3591 PF12157.8 EFC38161.1 - 7.6e-92 308.3 7.3 7.6e-92 308.3 7.3 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) ddrB-ParB PF18763.1 EFC38161.1 - 0.41 10.8 6.0 0.68 10.0 2.9 3.0 3 0 0 3 3 3 0 ddrB-like ParB superfamily domain HAP1_N PF04849.13 EFC38162.1 - 0.00037 19.8 17.9 0.0019 17.5 17.9 1.9 1 1 0 1 1 1 1 HAP1 N-terminal conserved region MAD PF05557.13 EFC38162.1 - 0.0038 15.7 14.8 0.0059 15.0 14.8 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein HIP1_clath_bdg PF16515.5 EFC38162.1 - 0.021 15.4 15.6 0.039 14.6 13.9 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4535 PF15054.6 EFC38162.1 - 0.2 11.4 2.7 1.7 8.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4535) ARD PF03079.14 EFC38162.1 - 0.23 11.6 7.4 0.52 10.5 7.4 1.5 1 0 0 1 1 1 0 ARD/ARD' family TPR_MLP1_2 PF07926.12 EFC38162.1 - 0.29 11.2 18.4 0.56 10.3 18.4 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Phlebovirus_NSM PF07246.11 EFC38162.1 - 0.52 9.6 14.1 0.88 8.9 14.1 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M HALZ PF02183.18 EFC38162.1 - 0.94 9.8 7.8 4 7.7 0.6 3.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper Exonuc_VII_L PF02601.15 EFC38162.1 - 1 8.9 9.3 0.15 11.6 5.4 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit YabA PF06156.13 EFC38162.1 - 2 9.1 16.5 12 6.6 1.3 3.5 1 1 2 3 3 3 0 Initiation control protein YabA TMPIT PF07851.13 EFC38162.1 - 3.7 6.7 12.0 6.2 6.0 12.0 1.3 1 0 0 1 1 1 0 TMPIT-like protein Prominin PF05478.11 EFC38162.1 - 4.3 5.2 9.1 6 4.7 9.1 1.1 1 0 0 1 1 1 0 Prominin DUF4407 PF14362.6 EFC38162.1 - 4.4 6.6 11.5 52 3.1 11.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 EFC38162.1 - 6 6.7 24.3 3.2 7.6 3.1 3.4 1 1 2 3 3 3 0 Septum formation initiator THOC7 PF05615.13 EFC38162.1 - 7.1 6.9 22.8 2.4 8.4 11.4 3.4 2 1 1 3 3 3 0 Tho complex subunit 7 IQ PF00612.27 EFC38163.1 - 0.039 13.7 1.0 0.13 12.1 1.0 2.0 1 0 0 1 1 1 0 IQ calmodulin-binding motif LPP PF04728.13 EFC38163.1 - 0.3 11.5 4.6 2.7 8.5 0.0 3.8 3 1 0 3 3 3 0 Lipoprotein leucine-zipper F5_F8_type_C PF00754.25 EFC38165.1 - 2.9e-21 75.9 0.5 3.3e-21 75.7 0.5 1.0 1 0 0 1 1 1 1 F5/8 type C domain Glyco_transf_18 PF15024.6 EFC38166.1 - 1.2e-09 37.4 5.8 1.8e-09 36.8 5.8 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 Glyco_transf_54 PF04666.13 EFC38166.1 - 2.3e-05 23.4 0.3 4.4e-05 22.5 0.3 1.5 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Imm58 PF15581.6 EFC38166.1 - 0.072 13.2 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 58 Armet PF10208.9 EFC38166.1 - 0.11 12.5 3.5 5.4 7.0 0.3 2.5 2 0 0 2 2 2 0 Degradation arginine-rich protein for mis-folding TerB PF05099.13 EFC38166.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TerB Metallophos PF00149.28 EFC38168.1 - 2.8e-34 119.4 0.3 3.9e-34 118.9 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFC38168.1 - 0.088 13.3 0.1 0.24 11.9 0.1 1.8 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain TipAS PF07739.13 EFC38169.1 - 0.0084 16.6 0.9 0.017 15.7 0.9 1.5 1 0 0 1 1 1 1 TipAS antibiotic-recognition domain TMF_TATA_bd PF12325.8 EFC38169.1 - 0.13 12.4 7.9 0.33 11.2 7.9 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FapA PF03961.13 EFC38169.1 - 6.7 5.2 10.3 16 3.9 10.3 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A HMG-CoA_red PF00368.18 EFC38170.1 - 1.3e-141 471.9 2.0 1.8e-141 471.5 2.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase NTP_transferase PF00483.23 EFC38171.1 - 7.5e-54 182.9 0.0 1.2e-53 182.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EFC38171.1 - 7.5e-13 47.7 5.2 8.3e-11 41.2 2.0 2.5 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFC38171.1 - 1.9e-10 41.3 0.0 2.4e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EFC38171.1 - 0.00014 21.5 3.1 0.0003 20.5 1.7 2.3 2 0 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EFC38171.1 - 0.0021 17.1 0.5 0.0086 15.1 0.2 2.1 2 1 1 3 3 3 1 L-fucokinase DUF4387 PF14330.6 EFC38171.1 - 0.013 16.1 0.1 0.17 12.6 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4387) CTP_transf_3 PF02348.19 EFC38171.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Cytidylyltransferase Epimerase PF01370.21 EFC38172.1 - 4.5e-45 154.0 0.0 5.9e-45 153.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC38172.1 - 2.4e-13 50.2 0.0 5.4e-13 49.0 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC38172.1 - 5.6e-06 25.7 0.1 0.0018 17.5 0.0 2.8 3 1 1 4 4 4 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFC38172.1 - 5.8e-06 25.5 0.1 1.8e-05 23.9 0.0 1.7 1 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFC38172.1 - 5.1e-05 22.5 0.0 0.00011 21.4 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain Glyco_transf_10 PF00852.19 EFC38173.1 - 1.3e-29 103.2 0.6 7.9e-29 100.6 0.3 2.3 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DUF2681 PF10883.8 EFC38173.1 - 0.0009 19.6 2.9 0.0043 17.4 3.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2681) FucT_N PF18025.1 EFC38173.1 - 0.079 13.4 1.7 4.5 7.8 0.0 3.1 3 0 0 3 3 3 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain DUF4446 PF14584.6 EFC38173.1 - 0.12 12.3 2.3 0.26 11.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) ORF6C PF10552.9 EFC38173.1 - 0.43 10.7 7.0 0.097 12.8 2.7 2.2 2 0 0 2 2 2 0 ORF6C domain GDP_Man_Dehyd PF16363.5 EFC38174.1 - 5.7e-154 512.4 0.0 6.5e-154 512.3 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC38174.1 - 2.6e-72 243.2 0.0 3.3e-72 242.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFC38174.1 - 2.5e-05 23.5 0.0 3.6e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFC38174.1 - 0.00056 19.1 0.0 0.00078 18.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFC38174.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding Glyco_transf_10 PF00852.19 EFC38175.1 - 9.1e-25 87.4 1.0 1.6e-24 86.6 1.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term TINF2_N PF14973.6 EFC38175.1 - 0.042 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus IPK PF03770.16 EFC38176.1 - 1.2e-39 136.3 1.9 5.3e-39 134.1 0.4 2.8 2 1 0 2 2 2 1 Inositol polyphosphate kinase F-box PF00646.33 EFC38176.1 - 2.8e-06 27.1 0.5 6.3e-06 25.9 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC38176.1 - 0.00023 21.0 0.2 0.00072 19.4 0.2 1.9 1 0 0 1 1 1 1 F-box-like Cas_Csy2 PF09614.10 EFC38176.1 - 0.07 12.5 0.7 0.14 11.5 0.7 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy2) ENTH PF01417.20 EFC38177.1 - 2e-10 40.7 0.8 2.3e-05 24.4 0.1 2.3 2 0 0 2 2 2 2 ENTH domain ANTH PF07651.16 EFC38177.1 - 2.9e-07 29.8 1.9 1.8e-05 23.9 0.4 2.2 2 0 0 2 2 2 2 ANTH domain HEAT PF02985.22 EFC38177.1 - 0.0041 17.3 0.2 4.8 7.7 0.0 3.6 3 0 0 3 3 3 1 HEAT repeat SYCP2_ARLD PF18581.1 EFC38177.1 - 0.051 13.6 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Synaptonemal complex 2 armadillo-repeat-like domain VHS PF00790.19 EFC38177.1 - 0.099 12.5 0.5 0.59 10.0 0.1 2.4 2 0 0 2 2 2 0 VHS domain Cnd1 PF12717.7 EFC38177.1 - 0.1 12.6 0.1 10 6.1 0.0 2.4 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF908 PF06012.12 EFC38177.1 - 0.25 10.7 7.1 0.5 9.7 6.5 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) RNA_pol PF00940.19 EFC38178.1 - 2.9e-165 550.1 0.0 9.3e-165 548.5 0.0 1.8 1 1 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 EFC38178.1 - 2.4e-56 191.6 0.1 4.7e-56 190.6 0.1 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal DUF3368 PF11848.8 EFC38178.1 - 0.067 13.0 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) V-SNARE PF05008.15 EFC38178.1 - 0.076 13.4 2.7 0.26 11.7 2.7 1.9 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus ATP-synt_D PF01813.17 EFC38179.1 - 1.9e-68 230.2 5.2 2.6e-68 229.7 5.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit D GIDA_assoc PF13932.6 EFC38179.1 - 0.011 15.9 3.4 0.012 15.8 2.7 1.4 1 1 0 1 1 1 0 GidA associated domain AAA_31 PF13614.6 EFC38179.1 - 0.21 11.5 3.6 0.44 10.4 0.1 2.4 2 1 1 3 3 3 0 AAA domain DUF4672 PF15716.5 EFC38179.1 - 0.25 11.0 3.0 0.26 10.9 0.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4672) Latarcin PF10279.9 EFC38179.1 - 3.3 8.2 6.6 0.66 10.4 2.1 2.2 2 1 1 3 3 3 0 Latarcin precursor DENN PF02141.21 EFC38180.1 - 3.8e-50 170.4 6.9 3.8e-50 170.4 6.9 1.9 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 EFC38180.1 - 3e-18 66.3 0.1 1.4e-17 64.2 0.1 2.3 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 EFC38180.1 - 8.2e-10 38.5 4.5 2.3e-09 37.1 4.5 1.9 1 0 0 1 1 1 1 dDENN domain DUF928 PF06051.12 EFC38180.1 - 0.093 12.6 0.2 0.18 11.7 0.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) F5_F8_type_C PF00754.25 EFC38181.1 - 0.01 16.0 0.3 0.018 15.1 0.3 1.4 1 0 0 1 1 1 0 F5/8 type C domain EGF_2 PF07974.13 EFC38182.1 - 1.5e-22 79.7 57.1 2.5e-06 27.7 9.5 4.5 4 0 0 4 4 4 4 EGF-like domain UPF0020 PF01170.18 EFC38182.1 - 9.2e-13 48.3 0.0 1.4e-11 44.5 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 EFC38182.1 - 5.2e-09 36.1 0.0 1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC38182.1 - 5.3e-07 30.2 0.0 1.3e-06 29.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC38182.1 - 1.8e-06 28.6 0.0 5.3e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC38182.1 - 0.00014 21.3 0.0 0.0002 20.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family AviRa PF11599.8 EFC38182.1 - 0.00077 19.0 0.0 0.0038 16.7 0.0 1.8 1 1 1 2 2 2 1 RRNA methyltransferase AviRa MTS PF05175.14 EFC38182.1 - 0.00084 18.9 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 EFC38182.1 - 0.022 14.6 0.0 0.063 13.1 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain EGF PF00008.27 EFC38182.1 - 0.025 14.9 43.1 0.36 11.2 5.7 5.0 4 0 0 4 4 4 0 EGF-like domain Met_10 PF02475.16 EFC38182.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein hEGF PF12661.7 EFC38182.1 - 2.2 9.1 53.5 0.46 11.2 6.1 5.0 4 0 0 4 4 4 0 Human growth factor-like EGF P34-Arc PF04045.14 EFC38183.1 - 7e-60 202.7 0.0 1.9e-59 201.3 0.0 1.6 2 0 0 2 2 2 1 Arp2/3 complex, 34 kD subunit p34-Arc Bactofilin PF04519.13 EFC38184.1 - 1.7e-10 41.0 12.3 0.00031 21.0 0.7 5.2 2 2 4 6 6 6 3 Polymer-forming cytoskeletal S4 PF01479.25 EFC38184.1 - 0.16 11.7 0.0 1.3 8.8 0.0 2.5 3 0 0 3 3 3 0 S4 domain YceI PF04264.13 EFC38184.1 - 0.49 11.0 4.9 8.6 6.9 1.9 4.0 1 1 2 3 3 3 0 YceI-like domain YabP PF07873.11 EFC38184.1 - 2.6 7.9 12.4 23 4.8 0.0 5.7 5 2 1 6 6 6 0 YabP family Transglycosylas PF06737.14 EFC38184.1 - 3.2 8.5 4.3 12 6.6 1.4 2.4 1 1 1 2 2 2 0 Transglycosylase-like domain FapA PF03961.13 EFC38184.1 - 4.9 5.7 8.5 0.89 8.1 3.4 2.2 2 1 0 2 2 2 0 Flagellar Assembly Protein A MmoB_DmpM PF02406.17 EFC38185.1 - 0.082 13.1 0.3 0.66 10.2 0.0 2.1 2 0 0 2 2 2 0 MmoB/DmpM family DUF188 PF02639.14 EFC38185.1 - 0.15 11.8 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Pkinase PF00069.25 EFC38186.1 - 1.6e-09 37.6 4.2 2.2e-09 37.1 4.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC38186.1 - 1.4e-06 27.3 0.5 2.8e-06 26.4 0.5 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC38186.1 - 0.00015 21.2 0.1 0.00025 20.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EFC38186.1 - 0.00055 19.3 0.8 0.00078 18.8 0.8 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFC38186.1 - 0.001 18.7 0.4 0.0024 17.5 0.4 1.6 1 0 0 1 1 1 1 RIO1 family EcKinase PF02958.20 EFC38186.1 - 0.0029 17.0 1.0 0.0052 16.1 1.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 EFC38186.1 - 0.12 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cyclin PF08613.11 EFC38187.1 - 1.2e-22 81.0 28.0 8.9e-21 74.9 25.3 3.8 1 1 1 2 2 2 1 Cyclin Cyclin_N PF00134.23 EFC38187.1 - 0.00011 21.9 0.1 0.00021 21.1 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Speriolin_N PF15058.6 EFC38189.1 - 0.011 15.8 1.4 0.011 15.8 1.4 5.7 5 2 2 7 7 7 0 Speriolin N terminus TM2 PF05154.16 EFC38190.1 - 6e-13 48.9 8.8 9.2e-13 48.3 8.8 1.3 1 0 0 1 1 1 1 TM2 domain DUF4252 PF14060.6 EFC38191.1 - 0.21 11.5 0.6 0.69 9.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) NADH_4Fe-4S PF10589.9 EFC38191.1 - 0.51 10.5 5.4 3.1 7.9 1.1 2.9 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region DUF2529 PF10740.9 EFC38192.1 - 0.063 12.9 0.3 7.8 6.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF2529) Androgen_recep PF02166.16 EFC38192.1 - 0.22 10.3 0.5 0.3 9.9 0.5 1.1 1 0 0 1 1 1 0 Androgen receptor Guanylate_cyc PF00211.20 EFC38193.1 - 3e-11 43.3 0.4 7.2e-11 42.0 0.4 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3852 PF12963.7 EFC38193.1 - 5.1 7.5 7.9 1 9.7 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) Sigma70_r4 PF04545.16 EFC38194.1 - 0.078 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 MAT1 PF06391.13 EFC38194.1 - 1.3 8.8 9.4 0.17 11.7 5.3 1.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 DUF563 PF04577.14 EFC38195.1 - 4.1e-39 134.9 1.0 5.7e-39 134.4 1.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) NHL PF01436.21 EFC38197.1 - 4.3e-43 143.2 5.4 3.1e-06 26.9 0.2 10.8 11 0 0 11 11 11 9 NHL repeat SGL PF08450.12 EFC38197.1 - 1.2e-08 34.9 0.4 0.048 13.2 0.0 5.1 2 2 2 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC38197.1 - 0.00013 22.1 2.9 7.9 6.8 0.0 5.9 6 1 0 6 6 6 1 Arylesterase SprB PF13573.6 EFC38197.1 - 0.016 14.9 0.3 0.062 13.1 0.3 2.1 1 0 0 1 1 1 0 SprB repeat GPS PF01825.21 EFC38197.1 - 0.023 15.2 0.1 0.042 14.4 0.1 1.5 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC38198.1 - 7.7e-32 109.3 245.8 0.0016 18.8 9.7 16.1 15 1 1 16 16 16 14 EGF-like domain REJ PF02010.15 EFC38198.1 - 1.6e-16 60.2 28.5 6.4e-16 58.2 15.6 4.2 3 1 1 4 4 4 2 REJ domain SIT PF15330.6 EFC38198.1 - 0.014 15.8 1.0 0.49 10.9 0.0 3.5 3 1 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT EGF_2 PF07974.13 EFC38199.1 - 1.9e-58 194.5 431.5 6.6e-05 23.2 6.7 27.9 27 0 0 27 27 27 25 EGF-like domain NHL PF01436.21 EFC38199.1 - 5.5e-44 146.1 13.9 6.3e-05 22.8 0.0 18.0 17 0 0 17 17 17 8 NHL repeat REJ PF02010.15 EFC38199.1 - 1.1e-24 87.1 15.4 1.3e-17 63.8 5.8 2.4 2 0 0 2 2 2 2 REJ domain DsrH PF04077.12 EFC38199.1 - 0.033 14.3 0.1 0.12 12.5 0.1 1.9 1 0 0 1 1 1 0 DsrH like protein EGF_2 PF07974.13 EFC38200.1 - 6.9e-25 87.1 142.3 0.00048 20.4 3.2 11.9 11 0 0 11 11 11 9 EGF-like domain NHL PF01436.21 EFC38200.1 - 4.6e-23 80.0 0.6 2.1e-05 24.3 0.0 7.2 6 0 0 6 6 6 4 NHL repeat REJ PF02010.15 EFC38200.1 - 1.1e-19 70.6 10.7 2.5e-19 69.4 10.7 1.5 1 0 0 1 1 1 1 REJ domain EGF PF00008.27 EFC38200.1 - 2.9e-05 24.3 128.0 0.089 13.1 2.0 12.7 12 0 0 12 12 12 8 EGF-like domain SGL PF08450.12 EFC38200.1 - 0.00029 20.5 0.3 5 6.6 0.0 3.7 2 1 2 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region DUF4834 PF16118.5 EFC38200.1 - 0.029 15.3 2.8 0.066 14.2 2.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Arylesterase PF01731.20 EFC38200.1 - 0.03 14.5 0.4 0.69 10.1 0.0 2.9 3 0 0 3 3 3 0 Arylesterase TMEM154 PF15102.6 EFC38200.1 - 0.044 13.7 0.5 0.1 12.5 0.5 1.6 1 0 0 1 1 1 0 TMEM154 protein family DAG1 PF05454.11 EFC38200.1 - 1.8 7.8 4.3 0.77 9.1 1.3 1.8 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF3774 PF12609.8 EFC38201.1 - 0.84 10.7 7.2 0.14 13.1 1.9 2.0 2 0 0 2 2 2 0 Wound-induced protein RWP-RK PF02042.15 EFC38205.1 - 0.00094 19.1 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 RWP-RK domain HTH_30 PF13556.6 EFC38205.1 - 0.042 13.7 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Sigma70_r4_2 PF08281.12 EFC38205.1 - 0.15 11.7 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 Pkinase PF00069.25 EFC38206.1 - 3.3e-11 43.1 0.9 9.2e-11 41.6 0.9 1.7 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFC38206.1 - 0.00024 20.5 0.2 0.00055 19.3 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC38206.1 - 0.00062 19.8 0.1 0.0012 18.8 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ank_2 PF12796.7 EFC38207.1 - 4.2e-14 52.9 4.1 7.5e-10 39.3 0.7 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC38207.1 - 1.3e-12 47.6 0.5 4.8e-09 36.3 0.2 3.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) VWA PF00092.28 EFC38207.1 - 6.1e-11 42.9 0.0 1.7e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Ank_3 PF13606.6 EFC38207.1 - 1.8e-10 40.1 2.4 0.00052 20.3 0.1 5.6 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 EFC38207.1 - 2e-10 41.0 2.0 1.4e-06 28.7 0.2 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC38207.1 - 9.3e-08 32.2 4.0 2.1e-05 24.7 0.4 3.6 3 0 0 3 3 3 1 Ankyrin repeat VWA_2 PF13519.6 EFC38207.1 - 4.7e-06 27.2 0.0 1.3e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-Nse PF11789.8 EFC38207.1 - 0.0004 20.1 1.8 0.0004 20.1 1.8 2.3 3 0 0 3 3 2 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 EFC38207.1 - 0.00055 20.1 0.1 0.0031 17.6 0.0 2.2 2 0 0 2 2 2 1 U-box domain zf-RING_UBOX PF13445.6 EFC38207.1 - 0.0064 16.5 0.6 0.019 15.0 0.6 1.9 1 0 0 1 1 1 1 RING-type zinc-finger VWA_3 PF13768.6 EFC38207.1 - 0.0074 16.2 0.0 0.019 14.9 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC38207.1 - 0.015 14.7 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein zf-C3HC4_4 PF15227.6 EFC38207.1 - 2.2 8.5 6.1 5.4 7.3 6.1 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFC38207.1 - 2.7 8.4 6.7 1.2 9.5 3.5 2.2 2 0 0 2 2 2 0 Ring finger domain Guanylate_cyc PF00211.20 EFC38208.1 - 8.7e-51 172.1 0.1 2.1e-50 170.9 0.1 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38208.1 - 1.1e-13 51.3 0.3 2.8e-13 50.0 0.3 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC38208.1 - 8.8e-07 28.9 0.0 2.1e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC38208.1 - 0.0074 16.3 0.0 0.023 14.7 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC38208.1 - 0.022 15.0 0.0 0.042 14.1 0.0 1.4 1 0 0 1 1 1 0 PAS fold DUF3487 PF11990.8 EFC38208.1 - 0.099 12.5 0.0 0.099 12.5 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF3487) RasGEF PF00617.19 EFC38209.1 - 1.2e-53 181.9 0.1 1.2e-53 181.9 0.1 2.9 3 0 0 3 3 3 1 RasGEF domain DOCK-C2 PF14429.6 EFC38209.1 - 1.6e-32 112.9 2.1 7.7e-32 110.7 0.1 3.2 3 0 0 3 3 3 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC38209.1 - 2.6e-22 79.0 1.5 2.6e-22 79.0 1.5 4.4 4 0 0 4 4 4 1 RasGEF N-terminal motif Hexapep PF00132.24 EFC38210.1 - 3.4e-14 51.9 22.0 2.8e-08 33.2 2.1 4.2 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFC38210.1 - 2.2e-06 27.3 3.8 2.2e-06 27.3 3.8 3.4 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase LRR_9 PF14580.6 EFC38211.1 - 9.7e-12 44.7 0.4 3.8e-11 42.8 0.1 2.0 1 1 1 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EFC38211.1 - 6.2e-08 32.8 0.2 4.1e-06 27.0 0.1 3.1 1 1 2 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38211.1 - 0.012 15.4 0.1 0.029 14.1 0.1 1.7 1 0 0 1 1 1 0 Leucine rich repeat Glyco_transf_10 PF00852.19 EFC38212.1 - 3.1e-27 95.4 0.1 5.6e-27 94.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_10 PF00852.19 EFC38213.1 - 2e-30 105.8 0.2 4.1e-30 104.8 0.2 1.5 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_transf_18 PF15024.6 EFC38214.1 - 4.9e-12 45.2 5.2 7.1e-12 44.7 5.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 STALD PF18185.1 EFC38214.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family WD40 PF00400.32 EFC38215.1 - 2.2e-21 75.8 17.2 0.003 18.4 0.0 10.8 11 0 0 11 11 11 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC38215.1 - 4.5e-13 49.3 0.4 0.002 18.4 0.0 6.6 4 3 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC38215.1 - 1.6e-08 34.2 11.1 0.00098 18.5 3.2 4.2 3 2 0 3 3 3 3 WD40-like domain PQQ_2 PF13360.6 EFC38215.1 - 9e-06 25.4 0.2 0.0057 16.3 0.0 3.2 2 1 1 3 3 3 2 PQQ-like domain Cytochrom_D1 PF02239.16 EFC38215.1 - 0.00066 18.3 0.8 0.48 8.9 0.0 3.9 4 0 0 4 4 4 1 Cytochrome D1 heme domain PQQ PF01011.21 EFC38215.1 - 0.0011 18.8 1.2 0.087 12.8 0.0 4.0 4 0 0 4 4 4 1 PQQ enzyme repeat PQQ_3 PF13570.6 EFC38215.1 - 0.016 15.7 1.8 5.8 7.5 0.1 5.3 6 0 0 6 6 6 0 PQQ-like domain Lyase_1 PF00206.20 EFC38216.1 - 9.9e-106 353.6 0.0 1.3e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 EFC38216.1 - 6.4e-22 77.7 0.0 1.6e-21 76.4 0.0 1.8 1 0 0 1 1 1 1 Fumarase C C-terminus UPF0020 PF01170.18 EFC38217.1 - 2e-13 50.5 0.1 6.6e-12 45.5 0.0 2.7 2 1 0 2 2 2 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 EFC38217.1 - 6.4e-09 35.8 0.0 1.5e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC38217.1 - 2.5e-07 31.3 0.0 7e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC38217.1 - 5.6e-07 30.1 0.0 1.4e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC38217.1 - 1.6e-05 24.3 0.0 2.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFC38217.1 - 0.0017 17.9 0.0 0.0037 16.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain AviRa PF11599.8 EFC38217.1 - 0.0018 17.8 0.0 0.0057 16.2 0.0 1.7 1 1 1 2 2 2 1 RRNA methyltransferase AviRa THUMP PF02926.17 EFC38217.1 - 0.0029 17.7 0.1 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 THUMP domain Methyltransf_23 PF13489.6 EFC38217.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain HSP70 PF00012.20 EFC38218.1 - 8.8e-250 830.0 15.7 1e-249 829.8 15.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC38218.1 - 3.1e-18 65.7 0.5 6.6e-15 54.8 0.1 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 EFC38218.1 - 0.0011 18.7 0.0 0.0081 15.9 0.0 2.4 3 0 0 3 3 3 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 EFC38218.1 - 0.0079 15.5 0.5 0.23 10.7 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase FtsA PF14450.6 EFC38218.1 - 0.033 14.6 4.1 0.8 10.2 0.4 3.2 3 2 0 3 3 3 0 Cell division protein FtsA DUF4268 PF14088.6 EFC38218.1 - 0.6 10.0 12.4 0.22 11.4 2.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4268) Peptidase_C48 PF02902.19 EFC38219.1 - 1.4e-29 103.5 0.3 1.4e-29 103.5 0.3 2.3 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain ATP-cone PF03477.16 EFC38219.1 - 0.074 13.6 6.3 3.5 8.3 1.6 2.6 2 0 0 2 2 2 0 ATP cone domain NHL PF01436.21 EFC38220.1 - 0.00033 20.5 0.1 0.017 15.1 0.0 2.9 3 0 0 3 3 3 1 NHL repeat LuxC PF05893.14 EFC38220.1 - 0.11 11.6 0.1 0.2 10.7 0.0 1.4 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) DUF4246 PF14033.6 EFC38222.1 - 4.7e-65 220.5 31.1 4.7e-44 151.3 0.3 4.5 1 1 1 4 4 4 3 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 EFC38222.1 - 0.11 12.9 0.0 0.44 11.0 0.0 2.1 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase DUF2722 PF10846.8 EFC38222.1 - 0.28 10.1 9.7 0.011 14.7 3.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2722) DUF1993 PF09351.10 EFC38222.1 - 0.51 10.5 1.7 0.72 10.0 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) BUD22 PF09073.10 EFC38222.1 - 0.88 8.8 24.1 0.028 13.8 15.0 2.1 2 0 0 2 2 2 0 BUD22 SelP_N PF04592.14 EFC38222.1 - 5.1 6.4 12.7 0.13 11.7 5.4 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DUF1647 PF07801.11 EFC38224.1 - 6.3e-06 26.0 11.9 9e-06 25.5 0.1 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF1647) Aconitase PF00330.20 EFC38225.1 - 1.1e-182 608.2 0.0 1.5e-182 607.7 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFC38225.1 - 1.2e-40 138.8 0.0 3.5e-40 137.4 0.0 1.8 1 0 0 1 1 1 1 Aconitase C-terminal domain BTB PF00651.31 EFC38226.1 - 6.7e-10 39.2 0.9 1.3e-09 38.3 0.9 1.5 1 0 0 1 1 1 1 BTB/POZ domain Death PF00531.22 EFC38226.1 - 0.08 13.1 0.1 0.24 11.6 0.1 1.8 1 0 0 1 1 1 0 Death domain DMP12 PF16779.5 EFC38226.1 - 0.093 12.7 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 DNA-mimic protein DTHCT PF08070.11 EFC38226.1 - 0.96 10.2 14.1 0.11 13.3 8.5 2.2 2 0 0 2 2 2 0 DTHCT (NUC029) region DUF2722 PF10846.8 EFC38226.1 - 3.9 6.3 7.3 6.1 5.7 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) NHL PF01436.21 EFC38228.1 - 1.5e-20 72.1 0.5 8.2e-06 25.6 0.0 7.3 7 0 0 7 7 7 3 NHL repeat GPS PF01825.21 EFC38228.1 - 0.0012 19.4 0.3 0.003 18.0 0.3 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Shisa PF13908.6 EFC38228.1 - 0.002 18.4 0.7 0.0053 17.0 0.7 1.7 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator YajC PF02699.15 EFC38228.1 - 0.0028 17.5 0.8 0.01 15.7 0.8 2.0 1 0 0 1 1 1 1 Preprotein translocase subunit TMEM154 PF15102.6 EFC38228.1 - 0.0067 16.3 3.0 0.019 14.8 3.0 1.7 1 0 0 1 1 1 1 TMEM154 protein family Amnionless PF14828.6 EFC38228.1 - 0.007 15.3 0.7 0.011 14.6 0.7 1.2 1 0 0 1 1 1 1 Amnionless RIFIN PF02009.16 EFC38228.1 - 0.0089 16.0 5.4 0.014 15.3 5.4 1.4 1 1 0 1 1 1 1 Rifin EphA2_TM PF14575.6 EFC38228.1 - 0.0097 16.8 1.3 0.063 14.2 0.4 2.3 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 EFC38228.1 - 0.012 15.1 3.0 0.023 14.1 3.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Stevor PF17410.2 EFC38228.1 - 0.013 15.0 2.1 0.029 13.9 2.1 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Orf78 PF06024.12 EFC38228.1 - 0.022 15.0 1.2 0.057 13.7 1.2 1.6 1 0 0 1 1 1 0 Orf78 (ac78) Protocadherin PF08374.11 EFC38228.1 - 0.037 14.0 0.6 0.075 13.0 0.6 1.5 1 0 0 1 1 1 0 Protocadherin SKG6 PF08693.10 EFC38228.1 - 0.045 13.2 9.3 0.096 12.1 9.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Sigma_reg_N PF13800.6 EFC38228.1 - 0.047 14.0 2.5 0.084 13.2 0.2 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF4577 PF15145.6 EFC38228.1 - 0.065 13.3 2.8 0.2 11.7 1.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4577) MpPF26 PF07666.11 EFC38228.1 - 0.066 13.3 5.2 0.13 12.4 1.8 2.5 2 0 0 2 2 2 0 M penetrans paralogue family 26 DAG1 PF05454.11 EFC38228.1 - 0.09 12.1 0.7 0.14 11.6 0.7 1.3 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) SP_C-Propep PF08999.10 EFC38228.1 - 0.098 12.5 0.5 0.59 9.9 0.3 2.2 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide DUF3278 PF11683.8 EFC38228.1 - 0.97 9.5 4.4 0.46 10.6 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3278) DUF4006 PF13179.6 EFC38228.1 - 2.6 8.0 6.6 0.83 9.6 0.5 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF4006) Baculo_11_kDa PF06143.11 EFC38228.1 - 3 7.5 6.8 0.36 10.4 1.7 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF3377 PF11857.8 EFC38228.1 - 4.4 7.3 5.6 0.4 10.6 0.6 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF3377) EGF_2 PF07974.13 EFC38229.1 - 6.9e-49 163.9 257.6 1.3e-05 25.4 5.0 17.9 17 1 0 17 17 17 13 EGF-like domain REJ PF02010.15 EFC38229.1 - 3.8e-23 82.0 19.2 7.2e-20 71.2 13.6 2.9 2 2 0 2 2 2 2 REJ domain PKD_2 PF16407.5 EFC38229.1 - 0.015 15.5 15.1 0.16 12.1 0.1 5.2 3 2 1 5 5 5 0 PKD-like family Chordopox_A13L PF05961.11 EFC38229.1 - 0.12 12.6 0.2 0.33 11.2 0.2 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Trypan_PARP PF05887.11 EFC38230.1 - 1.8e-06 27.9 98.8 0.0081 16.1 36.8 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) Pkinase_Tyr PF07714.17 EFC38231.1 - 9.5e-23 80.8 0.0 1.4e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC38231.1 - 5.8e-20 71.8 0.0 9.3e-20 71.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Adeno_E1B_55K PF01696.17 EFC38231.1 - 0.0088 14.8 0.2 0.015 14.0 0.2 1.3 1 0 0 1 1 1 1 Adenovirus EB1 55K protein / large t-antigen DUF4436 PF14494.6 EFC38231.1 - 0.0092 15.3 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4436) Fructosamin_kin PF03881.14 EFC38231.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Fructosamine kinase Chlam_PMP PF02415.17 EFC38231.1 - 0.26 11.8 0.1 0.26 11.8 0.1 5.8 7 0 0 7 7 7 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pkinase PF00069.25 EFC38232.1 - 2.1e-13 50.3 0.0 3.3e-13 49.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38232.1 - 7.1e-12 45.1 0.1 4.7e-05 22.8 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase WD40 PF00400.32 EFC38233.1 - 4.4e-32 109.6 30.8 0.00067 20.4 0.1 11.2 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC38233.1 - 2.5e-16 59.7 4.8 4e-07 30.3 0.0 7.9 2 2 6 9 9 9 3 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 EFC38233.1 - 2.2e-08 33.8 0.0 6.1e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 HELP motif Reg_prop PF07494.11 EFC38233.1 - 0.00066 19.6 0.0 7 7.2 0.1 4.6 4 0 0 4 4 4 2 Two component regulator propeller PQQ_3 PF13570.6 EFC38233.1 - 0.45 11.1 7.3 20 5.8 0.4 4.9 5 0 0 5 5 5 0 PQQ-like domain EamA PF00892.20 EFC38234.1 - 8.2e-20 71.4 39.7 5.2e-12 46.1 19.5 3.2 2 1 0 2 2 2 2 EamA-like transporter family YtpI PF14007.6 EFC38234.1 - 0.37 11.0 5.5 4 7.6 0.9 4.0 3 0 0 3 3 3 0 YtpI-like protein TssO PF17561.2 EFC38234.1 - 0.67 10.1 3.2 6.3 6.9 0.0 3.2 3 0 0 3 3 3 0 Type VI secretion system, TssO Peptidase_U4 PF03419.13 EFC38234.1 - 3.2 7.0 19.8 0.073 12.4 6.7 2.8 3 0 0 3 3 3 0 Sporulation factor SpoIIGA PhyH PF05721.13 EFC38236.1 - 1.6e-06 28.5 0.0 3.6e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 EFC38236.1 - 0.025 15.0 0.0 0.067 13.6 0.0 1.7 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Pkinase PF00069.25 EFC38238.1 - 5.6e-68 229.2 0.5 1.9e-67 227.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38238.1 - 1.1e-53 182.2 0.0 3.1e-53 180.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC38238.1 - 0.0011 18.3 0.4 0.0026 17.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFC38238.1 - 0.039 13.9 0.0 0.12 12.3 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Med19 PF10278.9 EFC38238.1 - 0.12 12.2 9.3 0.36 10.7 9.3 1.7 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Arm PF00514.23 EFC38239.1 - 2.5e-14 52.7 1.9 0.12 12.4 0.0 7.5 7 1 0 7 7 7 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC38239.1 - 0.00083 19.8 0.0 0.73 10.4 0.0 3.5 3 0 0 3 3 3 1 HEAT-like repeat RICTOR_V PF14668.6 EFC38239.1 - 0.0046 17.2 0.6 1.1 9.6 0.0 3.8 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 GRAB PF10375.9 EFC38239.1 - 0.035 14.0 0.0 0.19 11.6 0.0 2.4 1 0 0 1 1 1 0 GRIP-related Arf-binding domain HEAT PF02985.22 EFC38239.1 - 0.15 12.4 0.1 27 5.4 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat Cauli_VI PF01693.16 EFC38240.1 - 3e-12 46.6 0.7 7.9e-12 45.3 0.7 1.8 1 0 0 1 1 1 1 Caulimovirus viroplasmin Myb_DNA-binding PF00249.31 EFC38240.1 - 8.1e-11 41.9 0.2 1.5e-10 41.1 0.2 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-CCCH_4 PF18044.1 EFC38240.1 - 1.8e-06 27.6 8.3 3.5e-06 26.7 8.3 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EFC38240.1 - 0.00026 20.8 5.4 0.00026 20.8 5.4 1.8 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFC38240.1 - 0.056 13.5 8.3 0.14 12.3 8.3 1.7 1 0 0 1 1 1 0 Zinc finger domain PP1 PF07430.11 EFC38240.1 - 0.13 12.3 0.1 0.27 11.3 0.1 1.5 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain zf-CCCH_2 PF14608.6 EFC38240.1 - 0.26 11.8 6.8 0.73 10.4 6.8 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EFC38240.1 - 0.48 11.1 6.8 0.18 12.5 0.8 3.1 2 0 0 2 2 2 0 Torus domain Peptidase_M24 PF00557.24 EFC38241.1 - 8.2e-39 133.5 0.2 1e-38 133.1 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 PAP2_3 PF14378.6 EFC38242.1 - 8.9e-09 35.3 13.1 0.0013 18.5 3.1 3.6 3 1 0 3 3 3 3 PAP2 superfamily PAP2 PF01569.21 EFC38242.1 - 0.0001 22.1 1.0 0.00021 21.1 1.0 1.6 1 0 0 1 1 1 1 PAP2 superfamily Cas_Csy4 PF09618.10 EFC38243.1 - 0.031 14.4 0.0 0.079 13.1 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) CTD_bind PF04818.13 EFC38244.1 - 4.8e-13 49.7 0.2 4.8e-13 49.7 0.2 3.5 5 0 0 5 5 5 1 RNA polymerase II-binding domain. CREPT PF16566.5 EFC38244.1 - 0.0072 16.5 1.6 0.0072 16.5 1.6 2.9 2 1 1 3 3 3 1 Cell-cycle alteration and expression-elevated protein in tumour DUF3763 PF12592.8 EFC38244.1 - 0.06 13.4 0.4 0.14 12.2 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3763) DUF5101 PF17031.5 EFC38244.1 - 0.68 10.1 5.7 2.2 8.4 4.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5101) BAF250_C PF12031.8 EFC38244.1 - 2.8 7.2 5.6 3.9 6.7 0.7 2.5 3 0 0 3 3 3 0 SWI/SNF-like complex subunit BAF250/Osa SSP160 PF06933.11 EFC38244.1 - 2.9 6.0 8.7 4 5.5 8.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Fib_alpha PF08702.10 EFC38244.1 - 6.4 6.9 12.6 2.6 8.2 1.3 3.0 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Cytomega_gL PF01801.16 EFC38245.1 - 0.0094 15.4 0.2 0.089 12.2 0.0 2.1 1 1 1 2 2 2 1 Cytomegalovirus glycoprotein L DUF1011 PF06237.12 EFC38246.1 - 3.6e-07 30.4 8.0 3.6e-07 30.4 8.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1011) DUF4231 PF14015.6 EFC38246.1 - 0.46 11.0 0.1 0.46 11.0 0.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF4231) Spore_YhaL PF14147.6 EFC38246.1 - 0.76 9.5 3.9 9.5 6.0 0.0 3.2 3 0 0 3 3 3 0 Sporulation protein YhaL DUF4131 PF13567.6 EFC38246.1 - 1 9.0 5.3 6.2 6.5 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) UL41A PF17591.2 EFC38246.1 - 4.1 7.6 5.4 1.6 8.9 0.0 2.9 3 0 0 3 3 3 0 Herpesvirus UL41A MCRS_N PF13325.6 EFC38246.1 - 5.9 6.8 7.3 0.63 10.0 0.6 2.1 2 0 0 2 2 2 0 N-terminal region of micro-spherule protein PAP2 PF01569.21 EFC38247.1 - 2.1e-11 43.7 0.0 4e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily VCPO_N PF17897.1 EFC38247.1 - 0.0018 18.1 0.0 0.0069 16.2 0.0 2.0 2 0 0 2 2 2 1 Vanadium chloroperoxidase N-terminal domain NAD_binding_10 PF13460.6 EFC38248.1 - 7.6e-06 25.9 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 EFC38248.1 - 4.9e-05 23.7 0.0 0.00012 22.5 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EFC38248.1 - 0.00014 21.4 0.0 0.00027 20.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFC38248.1 - 0.014 15.0 0.0 0.034 13.7 0.0 1.8 1 1 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.18 EFC38248.1 - 0.017 15.4 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 EFC38248.1 - 0.074 13.2 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DXP_reductoisom PF02670.16 EFC38248.1 - 0.12 13.1 0.0 0.33 11.7 0.0 1.8 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Adaptin_N PF01602.20 EFC38249.1 - 4.6e-116 388.4 11.0 5.9e-116 388.1 11.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 EFC38249.1 - 2.4e-21 76.0 0.0 7.5e-21 74.4 0.0 1.9 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 EFC38249.1 - 1e-11 45.1 0.0 3e-11 43.6 0.0 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain HEAT_2 PF13646.6 EFC38249.1 - 2.8e-06 27.6 0.8 1.9 8.9 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EFC38249.1 - 0.00067 19.7 0.3 2.7 8.5 0.1 3.9 3 0 0 3 3 3 1 HEAT repeat Coatomer_g_Cpla PF16381.5 EFC38249.1 - 0.0019 18.3 0.1 0.067 13.3 0.0 3.0 3 0 0 3 3 3 1 Coatomer subunit gamma-1 C-terminal appendage platform Vac14_Fab1_bd PF12755.7 EFC38249.1 - 0.038 14.6 0.6 0.47 11.1 0.4 3.0 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region B2-adapt-app_C PF09066.10 EFC38249.1 - 0.046 13.8 0.3 0.42 10.7 0.3 2.4 1 1 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain RasGEF_N_2 PF14663.6 EFC38249.1 - 0.073 13.5 0.3 9.5 6.7 0.0 3.2 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTP1_C1 PF10363.9 EFC38249.1 - 0.074 13.2 1.2 0.23 11.6 0.4 2.3 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 ELMO_CED12 PF04727.13 EFC38251.1 - 2e-34 119.2 2.4 2e-34 119.2 2.4 2.5 2 1 0 2 2 2 1 ELMO/CED-12 family TPR_2 PF07719.17 EFC38252.1 - 0.002 18.1 1.5 8.5 6.8 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38252.1 - 0.067 13.5 0.2 7.2 7.0 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38252.1 - 0.71 10.2 7.4 21 5.6 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Zn_clus PF00172.18 EFC38253.1 - 5.3e-09 36.0 10.7 1.6e-08 34.5 10.7 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_12 PF13424.6 EFC38253.1 - 0.01 16.1 0.1 0.031 14.5 0.1 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38253.1 - 0.012 15.4 2.7 0.044 13.6 1.7 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38253.1 - 0.077 13.1 2.2 0.25 11.6 1.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38253.1 - 0.45 10.9 3.1 7.2 7.1 1.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Guanylate_cyc PF00211.20 EFC38254.1 - 7.3e-32 110.5 0.4 4.6e-31 107.8 0.1 2.5 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38254.1 - 4.4e-15 55.8 0.2 1.2e-14 54.4 0.2 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC38254.1 - 3.6e-08 33.4 0.0 1.1e-07 31.9 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC38254.1 - 0.052 13.8 0.0 0.096 12.9 0.0 1.4 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC38254.1 - 0.084 12.3 1.3 0.16 11.4 0.0 2.1 2 0 0 2 2 2 0 Heme NO binding associated Guanylate_cyc PF00211.20 EFC38255.1 - 1.6e-05 24.6 0.0 2.5e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ODV-E18 PF10717.9 EFC38256.1 - 0.056 13.3 2.4 0.065 13.1 1.1 1.8 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Thioesterase PF00975.20 EFC38256.1 - 0.11 12.6 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 Thioesterase domain ZFYVE21_C PF16696.5 EFC38256.1 - 0.17 11.8 0.0 2.3 8.1 0.0 2.2 1 1 1 2 2 2 0 Zinc finger FYVE domain-containing protein 21 C-terminus Cyt-b5 PF00173.28 EFC38258.1 - 8.6e-21 73.9 0.2 1.1e-20 73.5 0.2 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain EFP_N PF08207.12 EFC38258.1 - 0.015 15.3 0.1 0.034 14.2 0.1 1.5 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Amnionless PF14828.6 EFC38258.1 - 0.12 11.2 0.1 0.12 11.1 0.1 1.0 1 0 0 1 1 1 0 Amnionless DUF3450 PF11932.8 EFC38259.1 - 0.0077 15.6 3.3 0.0077 15.6 3.3 5.3 2 2 4 6 6 6 2 Protein of unknown function (DUF3450) ATG16 PF08614.11 EFC38259.1 - 1.2 9.3 65.3 0.016 15.4 24.1 4.6 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) MAD PF05557.13 EFC38259.1 - 2.2 6.5 68.4 4.6 5.5 68.3 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein Linker_histone PF00538.19 EFC38260.1 - 1.8e-22 79.5 0.6 4.5e-22 78.2 0.6 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family Radial_spoke PF04712.12 EFC38260.1 - 0.00082 18.4 5.5 0.00087 18.4 5.5 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein CPSF100_C PF13299.6 EFC38260.1 - 0.024 14.8 7.6 0.037 14.2 7.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal MerR_1 PF13411.6 EFC38260.1 - 0.034 14.2 0.1 0.084 13.0 0.1 1.7 1 0 0 1 1 1 0 MerR HTH family regulatory protein MMU163 PF17119.5 EFC38260.1 - 0.075 12.2 6.0 0.1 11.8 6.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis FAM176 PF14851.6 EFC38260.1 - 0.2 11.3 5.2 0.3 10.8 5.2 1.4 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 EFC38260.1 - 0.21 9.8 14.0 0.24 9.7 14.0 1.1 1 0 0 1 1 1 0 CDC45-like protein GOLD_2 PF13897.6 EFC38260.1 - 0.25 11.8 3.2 0.42 11.1 3.2 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF913 PF06025.12 EFC38260.1 - 0.31 10.0 5.7 0.37 9.7 5.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.14 EFC38260.1 - 0.47 10.9 7.1 0.65 10.4 7.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.17 EFC38260.1 - 1.2 9.2 6.0 1.3 9.1 6.0 1.2 1 0 0 1 1 1 0 DDHD domain AAA_11 PF13086.6 EFC38260.1 - 2.2 8.0 9.9 2.5 7.8 9.9 1.2 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 EFC38260.1 - 3 6.6 10.3 3.4 6.4 10.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 EFC38260.1 - 3.7 6.2 7.4 4.1 6.1 7.4 1.1 1 0 0 1 1 1 0 Presenilin TPR_12 PF13424.6 EFC38261.1 - 6.7e-19 68.0 2.6 1.6e-07 31.5 0.1 4.5 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38261.1 - 4.5e-17 60.8 9.9 0.00037 20.5 0.0 6.2 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC38261.1 - 1.3e-15 56.2 4.5 0.0088 16.0 0.1 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38261.1 - 3.2e-14 52.1 5.2 0.0039 17.0 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38261.1 - 4.7e-13 48.2 4.4 0.04 14.0 0.0 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38261.1 - 1.5e-06 28.4 3.9 0.29 11.9 0.0 5.0 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38261.1 - 9.8e-06 25.3 0.0 0.11 12.4 0.0 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC38261.1 - 2.9e-05 24.5 0.0 11 7.2 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC38261.1 - 0.00027 20.4 0.2 0.63 9.4 0.0 2.3 1 1 0 2 2 2 2 MalT-like TPR region TPR_11 PF13414.6 EFC38261.1 - 0.0019 17.9 0.4 5.8 6.7 0.1 3.7 3 0 0 3 3 3 2 TPR repeat TPR_17 PF13431.6 EFC38261.1 - 0.002 18.4 0.0 3.1 8.4 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC38261.1 - 0.0064 16.7 5.0 1.3 9.2 0.5 3.8 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC38261.1 - 0.021 15.3 0.4 1.3 9.6 0.1 3.6 4 1 1 5 5 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC38261.1 - 0.026 14.2 10.4 0.16 11.7 0.1 4.1 3 1 1 4 4 4 0 26S proteasome subunit RPN7 TPR_9 PF13371.6 EFC38261.1 - 0.065 13.4 0.0 0.37 11.0 0.0 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 EFC38261.1 - 0.074 13.3 2.0 26 5.3 0.0 4.6 4 0 0 4 4 4 0 PPR repeat DSBA PF01323.20 EFC38261.1 - 0.079 12.7 0.9 1.6 8.5 0.1 2.7 2 1 1 3 3 3 0 DSBA-like thioredoxin domain TPR_16 PF13432.6 EFC38261.1 - 0.1 13.3 0.0 8.1 7.2 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat Peripla_BP_2 PF01497.18 EFC38261.1 - 0.15 11.6 1.5 6.9 6.2 0.1 3.0 2 1 1 3 3 3 0 Periplasmic binding protein Pkinase PF00069.25 EFC38262.1 - 9.9e-19 67.7 0.8 6.1e-18 65.1 0.5 1.9 1 1 1 2 2 2 1 Protein kinase domain Choline_kinase PF01633.20 EFC38262.1 - 9.4e-07 28.6 0.1 1.2e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 EFC38262.1 - 3.9e-05 23.1 0.0 5.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_DNA-binding PF00249.31 EFC38263.1 - 1.3e-09 38.0 3.0 4.8e-09 36.3 0.5 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain ZZ PF00569.17 EFC38263.1 - 8.9e-09 35.0 8.1 1.9e-08 33.9 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 EFC38263.1 - 0.00015 22.0 5.4 0.00034 20.8 0.5 2.8 3 0 0 3 3 3 1 Myb-like DNA-binding domain SWIRM PF04433.17 EFC38263.1 - 0.0016 18.7 2.7 0.0081 16.5 0.0 3.1 3 1 0 3 3 3 1 SWIRM domain C1_2 PF03107.16 EFC38263.1 - 2.1 8.8 14.0 0.087 13.2 8.1 1.8 2 0 0 2 2 2 0 C1 domain Cu-oxidase_2 PF07731.14 EFC38264.1 - 5.7e-20 71.4 1.6 2.7e-13 49.9 2.5 3.1 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFC38264.1 - 6.7e-14 51.9 0.4 6.1e-08 32.7 0.0 3.5 2 1 0 2 2 2 2 Multicopper oxidase TENA_THI-4 PF03070.16 EFC38265.1 - 0.0015 18.4 0.5 0.0039 17.0 0.5 1.7 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Paz_1 PF18349.1 EFC38265.1 - 0.06 13.3 0.3 0.18 11.8 0.3 1.9 1 0 0 1 1 1 0 PAZ domain 6PF2K PF01591.18 EFC38265.1 - 1.1 8.5 8.7 0.19 11.0 1.0 2.7 3 0 0 3 3 3 0 6-phosphofructo-2-kinase CitMHS PF03600.16 EFC38266.1 - 2.8e-52 177.8 21.3 2.8e-52 177.8 21.3 2.1 2 0 0 2 2 2 1 Citrate transporter Na_sulph_symp PF00939.19 EFC38266.1 - 8.1e-16 58.1 39.1 5.6e-11 42.2 15.2 2.7 2 1 0 2 2 2 2 Sodium:sulfate symporter transmembrane region ArsB PF02040.15 EFC38266.1 - 8.3e-10 38.6 30.8 5.3e-06 26.0 6.7 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein DUF4710 PF15828.5 EFC38267.1 - 0.039 14.1 1.5 0.039 14.1 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) TPR_8 PF13181.6 EFC38268.1 - 9.6e-10 37.9 0.0 0.0028 17.7 0.0 3.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38268.1 - 9.5e-09 34.7 0.2 0.00053 19.9 0.0 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38268.1 - 5e-08 32.4 0.0 0.00029 20.5 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC38268.1 - 3e-05 23.6 0.1 0.0023 17.6 0.0 2.9 2 0 0 2 2 2 1 TPR repeat TPR_14 PF13428.6 EFC38268.1 - 0.00063 20.4 0.0 0.035 14.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38268.1 - 0.00081 19.6 0.0 2.6 8.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC38268.1 - 0.0046 16.9 0.0 1.1 9.5 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC38268.1 - 0.0065 17.0 0.0 1.1 9.8 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC38268.1 - 0.01 15.9 0.0 5.9 7.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38268.1 - 0.018 15.6 0.1 2 9.2 0.1 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38268.1 - 0.019 15.3 1.1 16 6.2 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat PhoU_div PF01865.16 EFC38268.1 - 0.034 13.5 0.3 0.11 11.8 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF47 TPR_16 PF13432.6 EFC38268.1 - 0.038 14.7 0.0 11 6.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC38268.1 - 0.077 13.1 1.3 18 5.5 0.1 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat NTP_transf_2 PF01909.23 EFC38270.1 - 1.3e-05 25.4 0.1 4.2e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFC38270.1 - 0.00059 19.9 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase PAP_assoc PF03828.19 EFC38270.1 - 0.0072 16.5 0.1 0.0072 16.5 0.1 2.7 3 0 0 3 3 3 1 Cid1 family poly A polymerase RNA_lig_T4_1 PF09511.10 EFC38271.1 - 2.8e-18 66.6 0.0 2.8e-18 66.6 0.0 2.7 3 0 0 3 3 3 1 RNA ligase Penicillinase_R PF03965.16 EFC38271.1 - 1.1 9.6 6.3 2.9 8.3 0.1 2.6 2 1 0 2 2 2 0 Penicillinase repressor DGF-1_C PF11040.8 EFC38271.1 - 7 6.7 9.1 4.8 7.3 1.0 3.3 3 0 0 3 3 3 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus Sh_2 PF17512.2 EFC38272.1 - 0.023 14.5 7.1 0.14 12.0 2.1 2.5 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein DUF1910 PF08928.10 EFC38272.1 - 0.17 11.9 4.4 0.086 12.8 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) Ninjurin PF04923.12 EFC38272.1 - 0.84 9.6 6.0 0.085 12.8 0.6 2.1 2 0 0 2 2 2 0 Ninjurin Fer4_23 PF18009.1 EFC38274.1 - 0.034 14.5 0.0 0.065 13.7 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron-sulfur cluster binding domain RCC1 PF00415.18 EFC38276.1 - 2.3e-26 92.1 13.7 1.1e-08 35.5 0.1 7.2 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Trypsin PF00089.26 EFC38276.1 - 1e-22 81.1 0.2 3.1e-22 79.5 0.0 1.9 2 0 0 2 2 2 1 Trypsin RCC1_2 PF13540.6 EFC38276.1 - 1.4e-14 53.4 16.3 0.0028 17.4 0.2 6.6 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Trypsin_2 PF13365.6 EFC38276.1 - 0.034 15.0 0.0 0.12 13.3 0.0 2.0 2 0 0 2 2 2 0 Trypsin-like peptidase domain DUF2694 PF10904.8 EFC38276.1 - 0.17 11.9 0.0 0.39 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) DSPc PF00782.20 EFC38277.1 - 5e-10 39.3 0.4 5e-10 39.3 0.4 3.3 3 2 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC38277.1 - 0.00048 19.8 0.6 0.0012 18.5 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase C2 PF00168.30 EFC38278.1 - 1.1e-24 86.7 3.4 2.4e-11 43.8 0.0 3.2 3 1 0 3 3 3 2 C2 domain Biotin_lipoyl_2 PF13533.6 EFC38278.1 - 0.0011 18.7 0.1 56 3.7 0.0 4.3 4 0 0 4 4 4 0 Biotin-lipoyl like FRD2 PF03197.13 EFC38278.1 - 0.18 12.1 5.3 12 6.3 0.0 3.3 3 0 0 3 3 3 0 Bacteriophage FRD2 protein PRP1_N PF06424.12 EFC38278.1 - 0.54 10.7 5.6 1.2 9.5 5.6 1.6 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF4820 PF16091.5 EFC38278.1 - 3.6 6.9 7.4 5.5 6.3 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Rcd1 PF04078.13 EFC38279.1 - 0.0014 18.0 0.2 0.56 9.4 0.1 2.3 2 0 0 2 2 2 2 Cell differentiation family, Rcd1-like ANAPC3 PF12895.7 EFC38279.1 - 0.11 12.7 1.8 27 5.1 0.0 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC38279.1 - 0.15 12.5 0.4 1 9.9 0.2 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Com_YlbF PF06133.11 EFC38279.1 - 0.21 12.2 8.3 4.1 8.1 3.8 2.6 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA TPR_1 PF00515.28 EFC38279.1 - 1 9.3 9.7 6.1 6.8 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38279.1 - 5.6 7.3 12.1 3.1 8.2 0.1 5.0 5 2 2 7 7 7 0 Tetratricopeptide repeat Ank_4 PF13637.6 EFC38280.1 - 1.6e-07 31.7 0.1 0.0014 19.2 0.0 4.6 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC38280.1 - 8.7e-05 23.0 0.2 0.22 12.1 0.0 4.4 3 1 1 4 4 4 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC38280.1 - 0.02 15.4 0.0 1.2 9.9 0.0 3.9 3 0 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.6 EFC38280.1 - 0.13 12.6 0.0 9 6.8 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) DUF1951 PF09188.10 EFC38280.1 - 0.48 10.4 4.8 0.35 10.8 0.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1951) BRAP2 PF07576.12 EFC38281.1 - 3e-33 114.0 1.8 4e-33 113.6 0.3 2.0 2 0 0 2 2 2 1 BRCA1-associated protein 2 zf-UBP PF02148.19 EFC38281.1 - 1e-19 70.6 7.5 3.2e-19 69.0 7.5 1.9 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 EFC38281.1 - 2.3e-08 34.2 7.4 2.3e-08 34.2 7.4 2.4 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC38281.1 - 8.7e-07 28.7 7.3 2.4e-06 27.3 7.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC38281.1 - 1.4e-05 24.8 6.2 5.3e-05 23.0 6.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC38281.1 - 0.00033 20.3 3.9 0.00033 20.3 3.9 2.1 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EFC38281.1 - 0.00068 19.9 10.5 0.0031 17.8 10.5 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain UPF0242 PF06785.11 EFC38281.1 - 0.013 15.6 27.3 0.013 15.6 27.3 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus zf-ANAPC11 PF12861.7 EFC38281.1 - 0.02 14.9 8.4 0.057 13.5 8.4 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFC38281.1 - 0.11 12.6 9.6 0.18 11.8 6.5 2.5 1 1 1 2 2 2 0 RING-type zinc-finger DUF885 PF05960.11 EFC38281.1 - 0.22 11.1 6.9 0.36 10.4 6.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Hepar_II_III_N PF16889.5 EFC38282.1 - 3e-96 322.7 3.1 4e-96 322.3 3.1 1.2 1 0 0 1 1 1 1 Heparinase II/III N-terminus Hepar_II_III PF07940.13 EFC38282.1 - 1.3e-22 80.6 0.0 2.2e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Heparinase II/III-like protein EGF_2 PF07974.13 EFC38282.1 - 0.0093 16.3 9.3 0.0093 16.3 9.3 1.9 2 0 0 2 2 2 1 EGF-like domain DUF4446 PF14584.6 EFC38283.1 - 0.047 13.7 3.4 0.17 11.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) EphA2_TM PF14575.6 EFC38283.1 - 0.081 13.8 3.9 1.5 9.8 1.3 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 EFC38283.1 - 0.082 13.1 5.9 0.23 11.7 3.5 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF3139 PF11337.8 EFC38283.1 - 0.11 13.2 3.9 0.85 10.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) GAPT PF11770.8 EFC38283.1 - 0.2 11.5 4.0 2.9 7.7 1.1 2.2 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) OAD_gamma PF04277.13 EFC38283.1 - 0.55 10.9 2.1 7.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NHL PF01436.21 EFC38284.1 - 7.2e-39 129.9 2.6 1.4e-05 24.9 0.2 10.2 10 0 0 10 10 10 8 NHL repeat SGL PF08450.12 EFC38284.1 - 1.3e-10 41.3 1.2 0.0039 16.8 0.0 7.0 4 2 3 7 7 7 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC38284.1 - 7.5e-07 29.3 10.8 0.26 11.5 0.0 7.1 7 1 2 9 9 9 2 Arylesterase GPS PF01825.21 EFC38284.1 - 0.00021 21.7 0.9 0.00039 20.9 0.9 1.5 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Lactonase PF10282.9 EFC38284.1 - 0.0077 15.5 0.1 32 3.6 0.0 4.2 3 1 0 4 4 4 0 Lactonase, 7-bladed beta-propeller Shisa PF13908.6 EFC38284.1 - 1.1 9.4 5.9 0.15 12.3 1.8 1.6 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator TMEM210 PF15195.6 EFC38284.1 - 1.4 9.3 3.4 4 7.9 3.4 1.8 1 0 0 1 1 1 0 TMEM210 family DUF4116 PF13475.6 EFC38285.1 - 1.4e-19 69.5 29.3 0.00022 20.9 0.0 9.2 7 1 0 8 8 8 8 Domain of unknown function (DUF4116) zf-C2H2 PF00096.26 EFC38286.1 - 1.3e-16 60.0 17.7 1.9e-05 24.8 1.4 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFC38286.1 - 6.7e-16 57.9 17.7 2.8e-06 27.5 0.1 4.6 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFC38286.1 - 7.9e-06 26.3 28.1 0.0045 17.7 1.2 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2HE PF16278.5 EFC38286.1 - 0.00017 21.9 0.1 0.00078 19.8 0.1 2.2 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 EFC38286.1 - 0.0011 18.7 8.1 1.2 9.0 0.1 3.7 3 0 0 3 3 3 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 EFC38286.1 - 0.046 13.7 9.3 1.1 9.3 0.4 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 EFC38286.1 - 0.067 13.0 2.7 5.7 6.8 0.1 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-met PF12874.7 EFC38286.1 - 0.071 13.5 3.5 2.3 8.7 0.1 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-TRAF PF02176.18 EFC38286.1 - 0.3 11.8 6.9 0.096 13.4 1.6 2.2 1 1 1 2 2 2 0 TRAF-type zinc finger Zn-ribbon_8 PF09723.10 EFC38286.1 - 9.5 6.4 6.0 1.2 9.3 0.8 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Acetyltransf_1 PF00583.25 EFC38287.1 - 6.5e-09 36.1 0.0 9.8e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC38287.1 - 7.1e-08 32.4 0.1 1.1e-07 31.9 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC38287.1 - 7.1e-06 26.4 0.0 1.1e-05 25.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC38287.1 - 8.9e-05 22.6 0.1 0.00014 21.9 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC38287.1 - 9.4e-05 22.3 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFC38287.1 - 0.012 15.7 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 EFC38287.1 - 0.027 14.1 0.0 0.049 13.2 0.0 1.5 1 0 0 1 1 1 0 GNAT acetyltransferase PNMA PF14893.6 EFC38287.1 - 0.16 11.4 0.3 0.22 10.9 0.3 1.1 1 0 0 1 1 1 0 PNMA Myb_DNA-binding PF00249.31 EFC38289.1 - 7.2e-07 29.3 0.2 1.5e-06 28.2 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Guanylate_cyc PF00211.20 EFC38290.1 - 3.2e-52 176.8 0.0 6.1e-52 175.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38290.1 - 5.1e-15 55.6 0.2 1.4e-14 54.2 0.2 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC38290.1 - 4.8e-08 33.0 0.0 1.2e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC38290.1 - 0.055 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 PAS fold PAS_10 PF13596.6 EFC38290.1 - 0.098 13.3 0.2 1.4 9.5 0.0 2.8 2 0 0 2 2 2 0 PAS domain DUF3886 PF13025.6 EFC38290.1 - 0.12 12.6 5.4 0.43 10.8 5.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) HNOBA PF07701.14 EFC38290.1 - 0.17 11.3 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Heme NO binding associated TSNAXIP1_N PF15739.5 EFC38290.1 - 4.7 7.6 8.6 43 4.5 3.0 3.5 2 1 1 3 3 3 0 Translin-associated factor X-interacting N-terminus TMV_coat PF00721.21 EFC38291.1 - 0.015 15.2 0.1 0.018 14.9 0.1 1.3 1 0 0 1 1 1 0 Virus coat protein (TMV like) DUF4849 PF16141.5 EFC38291.1 - 0.043 13.1 0.2 0.055 12.7 0.2 1.2 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 RhoGEF PF00621.20 EFC38293.1 - 3.2e-14 53.6 8.1 4.2e-14 53.2 8.1 1.1 1 0 0 1 1 1 1 RhoGEF domain DUF2202 PF09968.9 EFC38293.1 - 0.013 15.3 1.9 2.5 8.0 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) Nitrate_red_del PF02613.15 EFC38293.1 - 0.037 14.0 0.7 0.11 12.5 0.2 2.0 2 1 0 2 2 2 0 Nitrate reductase delta subunit DUF3486 PF11985.8 EFC38293.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) P4Ha_N PF08336.11 EFC38293.1 - 0.39 10.7 6.9 0.11 12.4 1.0 2.6 1 1 2 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FCH PF00611.23 EFC38293.1 - 0.41 11.0 4.6 2.4 8.5 0.1 2.8 2 2 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Ion_trans_2 PF07885.16 EFC38294.1 - 8.3e-32 109.0 28.9 4.3e-17 61.8 5.0 3.3 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EFC38294.1 - 5.4e-10 38.9 28.1 1.3e-05 24.5 11.7 2.5 1 1 1 2 2 2 2 Ion transport protein Lig_chan PF00060.26 EFC38294.1 - 0.77 9.6 6.6 0.72 9.7 1.6 2.6 1 1 1 2 2 2 0 Ligand-gated ion channel G-alpha PF00503.20 EFC38295.1 - 1.3e-29 103.5 4.7 1.3e-29 103.5 4.7 1.9 2 0 0 2 2 2 1 G-protein alpha subunit LRR_4 PF12799.7 EFC38295.1 - 8e-05 22.9 6.9 0.0012 19.1 1.7 3.7 2 2 1 3 3 3 2 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC38295.1 - 0.0015 18.4 0.2 0.57 10.1 0.0 3.2 2 0 0 2 2 2 2 F-box domain Pkinase PF00069.25 EFC38296.1 - 2.1e-32 112.5 0.3 3.6e-32 111.8 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38296.1 - 8.3e-26 90.8 0.0 1.3e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC38296.1 - 3.7e-06 27.4 0.0 1.9e-05 25.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Pkinase_fungal PF17667.1 EFC38296.1 - 0.00012 21.0 0.0 0.00021 20.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Ank_3 PF13606.6 EFC38296.1 - 0.0021 18.4 0.2 0.028 14.9 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFC38296.1 - 0.015 15.9 0.0 0.083 13.5 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC38296.1 - 0.019 15.2 0.0 0.15 12.4 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Kdo PF06293.14 EFC38296.1 - 0.084 12.2 0.0 0.31 10.4 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mfa_like_2 PF15415.6 EFC38297.1 - 0.058 12.3 0.5 0.35 9.7 0.1 2.2 2 1 1 3 3 3 0 Fimbrillin-like BTB PF00651.31 EFC38299.1 - 8e-07 29.3 0.6 1.9e-06 28.1 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain LPAM_1 PF08139.12 EFC38299.1 - 0.0052 17.2 1.2 0.0052 17.2 1.2 2.6 3 0 0 3 3 3 1 Prokaryotic membrane lipoprotein lipid attachment site Cytochrom_C1 PF02167.15 EFC38300.1 - 1.5e-84 283.1 0.0 1.9e-84 282.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrom_C PF00034.21 EFC38300.1 - 0.0017 19.5 0.0 0.004 18.3 0.0 1.7 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EFC38300.1 - 0.0019 18.5 0.0 0.006 16.9 0.0 1.9 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III polyprenyl_synt PF00348.17 EFC38301.1 - 7.2e-39 133.4 0.0 8.6e-39 133.1 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase LRR_6 PF13516.6 EFC38302.1 - 2.8e-40 132.9 29.5 0.00036 20.3 0.2 12.3 12 0 0 12 12 12 9 Leucine Rich repeat LRR_8 PF13855.6 EFC38302.1 - 1.8e-28 98.1 36.1 2.5e-09 36.7 0.5 5.9 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC38302.1 - 1.5e-26 92.0 26.5 0.00043 20.6 0.3 8.3 1 1 10 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38302.1 - 4.9e-12 44.6 13.3 9.1 7.3 0.0 10.5 11 1 0 11 11 11 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC38302.1 - 6.7e-05 22.5 9.4 0.24 10.9 0.2 3.8 1 1 4 5 5 5 5 Leucine-rich repeat VirE_N PF08800.10 EFC38302.1 - 0.071 13.2 0.0 1.5 9.0 0.0 2.7 3 1 0 3 3 3 0 VirE N-terminal domain DUF4419 PF14388.6 EFC38303.1 - 2.1e-100 336.1 0.2 2.4e-100 335.8 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) YmdB PF13277.6 EFC38303.1 - 0.0086 15.4 0.0 0.017 14.4 0.0 1.4 1 1 0 1 1 1 1 YmdB-like protein SET PF00856.28 EFC38304.1 - 7.2e-12 46.0 3.5 9.8e-12 45.6 1.2 2.5 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 EFC38304.1 - 9e-05 22.5 11.9 9e-05 22.5 11.9 2.3 2 0 0 2 2 2 1 MYND finger TPR_2 PF07719.17 EFC38304.1 - 0.043 14.0 0.0 1 9.7 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TMF_TATA_bd PF12325.8 EFC38305.1 - 0.0046 17.2 19.5 0.0046 17.2 19.5 12.6 3 1 10 13 13 13 4 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 EFC38305.1 - 0.012 14.5 199.5 0.037 12.9 16.3 8.4 1 1 8 9 9 9 0 Spc7 kinetochore protein Filament PF00038.21 EFC38305.1 - 1.3 8.5 177.1 0.041 13.4 57.2 4.9 1 1 3 4 4 4 0 Intermediate filament protein Tubulin PF00091.25 EFC38306.1 - 2.3e-38 132.4 0.1 3.1e-37 128.7 0.1 2.5 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC38306.1 - 1.8e-18 66.9 1.3 2.7e-18 66.3 1.3 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC38306.1 - 0.00031 20.5 0.0 0.0014 18.3 0.0 2.1 2 0 0 2 2 2 1 Tubulin domain Sec2p PF06428.11 EFC38306.1 - 0.0067 16.4 0.7 0.14 12.1 0.0 2.3 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Pkinase PF00069.25 EFC38307.1 - 1.7e-71 240.7 0.0 2.5e-71 240.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38307.1 - 2.8e-31 108.7 0.0 8.1e-31 107.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC38307.1 - 8.6e-05 22.0 0.0 0.00022 20.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC38307.1 - 0.00063 18.8 17.5 0.00063 18.8 17.5 2.9 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFC38307.1 - 0.0022 17.4 1.3 0.0028 17.0 0.3 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Macoilin PF09726.9 EFC38307.1 - 1 7.8 45.3 0.0046 15.6 16.3 2.1 2 0 0 2 2 2 0 Macoilin family FAD_binding_1 PF00667.20 EFC38308.1 - 7.8e-42 143.3 0.0 2e-40 138.8 0.0 2.2 1 1 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFC38308.1 - 6.7e-25 88.0 0.0 2.2e-20 73.3 0.0 2.4 1 1 1 2 2 2 2 Flavodoxin NAD_binding_1 PF00175.21 EFC38308.1 - 6.6e-14 52.5 0.0 1.6e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFC38308.1 - 0.042 14.1 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Flavodoxin domain Flavodoxin_3 PF12641.7 EFC38308.1 - 0.058 13.1 0.0 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 Flavodoxin domain DUF667 PF05018.13 EFC38309.1 - 9.4e-77 256.9 1.4 1.6e-76 256.2 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Ank_4 PF13637.6 EFC38309.1 - 1.6e-21 76.4 0.1 2e-12 47.4 0.0 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC38309.1 - 3.3e-15 56.4 0.7 2.5e-14 53.6 0.4 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC38309.1 - 8.5e-13 48.3 0.0 1.8e-08 34.5 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC38309.1 - 5.3e-11 41.8 0.1 0.00013 22.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFC38309.1 - 2.4e-09 37.2 0.1 0.0031 17.9 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat UPF0640 PF15114.6 EFC38309.1 - 0.0029 17.4 0.6 0.0062 16.3 0.6 1.5 1 0 0 1 1 1 1 Uncharacterised protein family UPF0640 RGS PF00615.19 EFC38310.1 - 2.7e-11 43.8 1.6 1.6e-10 41.3 1.5 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain HAMP PF00672.25 EFC38310.1 - 7e-06 26.3 0.0 1.5e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 HAMP domain CHASE4 PF05228.13 EFC38310.1 - 0.0046 17.2 0.0 0.013 15.7 0.0 1.8 1 0 0 1 1 1 1 CHASE4 domain MitMem_reg PF13012.6 EFC38310.1 - 0.43 11.0 2.8 1.3 9.4 0.1 3.1 2 1 1 3 3 3 0 Maintenance of mitochondrial structure and function Fib_alpha PF08702.10 EFC38310.1 - 2 8.6 7.4 3.7 7.7 0.5 3.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AAA PF00004.29 EFC38311.1 - 1.8e-94 313.2 0.5 6.1e-48 162.6 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC38311.1 - 1.4e-27 95.2 0.1 1.4e-13 50.4 0.1 3.1 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 EFC38311.1 - 1e-14 54.6 0.0 4.8e-07 29.7 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFC38311.1 - 1.1e-13 51.6 0.0 2.2e-05 24.6 0.0 3.1 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFC38311.1 - 2.2e-13 50.9 0.7 0.00035 21.0 0.0 5.0 4 2 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 EFC38311.1 - 2.9e-11 43.8 4.0 0.0098 16.2 0.0 5.7 4 2 2 6 6 5 3 AAA domain TIP49 PF06068.13 EFC38311.1 - 3e-11 43.1 0.1 6.8e-06 25.5 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_5 PF07728.14 EFC38311.1 - 1.9e-10 40.9 2.0 0.00077 19.5 0.0 4.1 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 EFC38311.1 - 8.9e-10 38.4 0.1 0.00018 21.4 0.0 3.1 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain AAA_33 PF13671.6 EFC38311.1 - 2.1e-09 37.7 0.0 0.001 19.3 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EFC38311.1 - 3.2e-09 36.9 0.0 0.0016 18.4 0.0 3.3 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EFC38311.1 - 3.5e-09 37.0 0.0 0.0064 16.9 0.0 3.3 3 0 0 3 3 2 2 RNA helicase AAA_18 PF13238.6 EFC38311.1 - 4.1e-08 33.8 0.3 0.0098 16.4 0.0 3.5 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EFC38311.1 - 5.4e-08 32.5 0.2 0.0072 15.7 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EFC38311.1 - 1.4e-07 31.3 1.5 1.4 8.4 0.0 4.7 4 1 1 5 5 4 2 AAA domain NACHT PF05729.12 EFC38311.1 - 6e-07 29.5 0.2 0.015 15.2 0.0 3.5 4 0 0 4 4 3 2 NACHT domain AAA_28 PF13521.6 EFC38311.1 - 1.2e-06 28.9 0.0 0.05 13.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 EFC38311.1 - 2e-06 27.7 0.0 0.077 12.7 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 EFC38311.1 - 4.4e-06 26.7 0.0 0.16 11.9 0.0 2.7 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EFC38311.1 - 4.6e-06 27.2 6.7 0.023 15.2 0.0 4.2 3 1 0 3 3 2 2 ABC transporter Zeta_toxin PF06414.12 EFC38311.1 - 1e-05 24.9 0.1 0.2 10.9 0.0 2.7 2 0 0 2 2 2 2 Zeta toxin Rad17 PF03215.15 EFC38311.1 - 2e-05 24.6 0.3 0.38 10.6 0.0 3.6 2 2 1 3 3 3 2 Rad17 P-loop domain NB-ARC PF00931.22 EFC38311.1 - 3e-05 23.3 0.1 0.23 10.6 0.0 3.1 3 0 0 3 3 3 2 NB-ARC domain Sigma54_activat PF00158.26 EFC38311.1 - 6.8e-05 22.6 0.0 0.23 11.2 0.0 3.4 4 0 0 4 4 3 1 Sigma-54 interaction domain ATPase_2 PF01637.18 EFC38311.1 - 0.00011 22.2 7.9 0.79 9.6 0.0 5.0 3 2 1 4 4 4 2 ATPase domain predominantly from Archaea AAA_24 PF13479.6 EFC38311.1 - 0.00026 20.8 0.0 0.39 10.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain Cytidylate_kin2 PF13189.6 EFC38311.1 - 0.00029 21.0 0.2 0.04 14.1 0.0 3.0 3 0 0 3 3 3 1 Cytidylate kinase-like family AAA_3 PF07726.11 EFC38311.1 - 0.00029 20.7 0.0 0.74 9.7 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 EFC38311.1 - 0.00042 20.1 3.4 1 9.1 0.0 3.4 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase Parvo_NS1 PF01057.17 EFC38311.1 - 0.00045 19.4 0.1 0.94 8.5 0.0 2.5 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EFC38311.1 - 0.0009 18.8 0.2 1.6 8.2 0.0 3.1 3 1 0 3 3 2 2 P-loop containing dynein motor region ATPase PF06745.13 EFC38311.1 - 0.001 18.5 3.3 0.93 8.8 0.0 3.8 4 0 0 4 4 4 2 KaiC Macoilin PF09726.9 EFC38311.1 - 0.0018 17.0 12.9 0.0018 17.0 12.9 1.9 2 0 0 2 2 2 1 Macoilin family DUF815 PF05673.13 EFC38311.1 - 0.0061 15.8 0.0 1 8.5 0.0 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 EFC38311.1 - 0.0062 16.3 0.0 5.1 6.8 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Bac_DnaA PF00308.18 EFC38311.1 - 0.0067 16.3 0.0 5.2 6.8 0.0 2.7 2 1 0 2 2 2 0 Bacterial dnaA protein Sigma54_activ_2 PF14532.6 EFC38311.1 - 0.0067 16.5 0.0 0.67 10.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NTPase_1 PF03266.15 EFC38311.1 - 0.0069 16.3 0.7 11 5.9 0.0 4.3 3 1 1 4 4 4 0 NTPase CPT PF07931.12 EFC38311.1 - 0.0076 16.1 0.0 0.57 10.0 0.0 2.5 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 EFC38311.1 - 0.011 16.2 12.5 0.29 11.5 0.0 4.6 4 2 0 4 4 3 0 AAA domain AFG1_ATPase PF03969.16 EFC38311.1 - 0.021 13.7 0.0 0.63 8.9 0.0 2.6 2 1 0 2 2 2 0 AFG1-like ATPase Nucleolin_bd PF16725.5 EFC38311.1 - 0.029 14.0 0.5 0.27 10.9 0.0 2.5 2 0 0 2 2 2 0 Nucleolin binding domain PhoH PF02562.16 EFC38311.1 - 0.032 13.7 0.4 10 5.5 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein SKI PF01202.22 EFC38311.1 - 0.056 13.6 1.8 9.1 6.4 0.0 3.3 3 0 0 3 3 3 0 Shikimate kinase MMR_HSR1 PF01926.23 EFC38311.1 - 0.065 13.3 0.1 12 6.0 0.0 3.5 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_19 PF13245.6 EFC38311.1 - 0.14 12.5 1.1 18 5.7 0.1 2.8 2 1 0 2 2 2 0 AAA domain FeoB_N PF02421.18 EFC38311.1 - 0.63 9.5 3.7 3.7 7.1 0.0 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B Menin PF05053.13 EFC38311.1 - 3.7 5.8 14.1 7 4.9 14.1 1.4 1 0 0 1 1 1 0 Menin Hydin_ADK PF17213.3 EFC38311.1 - 5.2 7.3 22.8 6.1 7.1 0.0 4.0 4 0 0 4 4 3 0 Hydin Adenylate kinase-like domain JAB PF01398.21 EFC38312.1 - 1.4e-13 50.9 0.2 3.4e-13 49.6 0.1 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFC38312.1 - 0.00061 20.2 4.6 0.00061 20.2 4.6 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Cnn_1N PF07989.11 EFC38312.1 - 0.45 10.7 4.8 0.14 12.4 1.4 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 UPF0449 PF15136.6 EFC38312.1 - 1.3 9.5 4.7 0.51 10.8 1.4 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 GATA PF00320.27 EFC38313.1 - 0.00014 21.4 9.0 0.0028 17.2 0.2 2.8 3 0 0 3 3 3 2 GATA zinc finger Tir_receptor_C PF07489.11 EFC38313.1 - 0.099 12.6 6.0 0.03 14.3 3.6 1.4 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus Dicty_REP PF05086.12 EFC38313.1 - 0.15 10.0 4.8 0.17 9.8 4.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SWIRM-assoc_2 PF16496.5 EFC38313.1 - 0.51 9.1 5.2 0.64 8.8 5.2 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Integrin_alpha PF00357.20 EFC38313.1 - 2.4 8.3 5.5 0.62 10.2 1.7 2.1 2 0 0 2 2 2 0 Integrin alpha cytoplasmic region VirB3 PF05101.13 EFC38314.1 - 1.6 9.0 3.6 0.9 9.8 0.2 2.0 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein Ank_3 PF13606.6 EFC38315.1 - 0.019 15.4 0.2 44 5.1 0.0 4.8 4 0 0 4 4 4 0 Ankyrin repeat DUF2838 PF10998.8 EFC38315.1 - 0.065 13.5 0.0 0.25 11.6 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2838) RRM_2 PF04059.12 EFC38315.1 - 0.24 11.6 1.6 20 5.5 0.0 3.3 3 0 0 3 3 3 0 RNA recognition motif 2 Acetyltransf_1 PF00583.25 EFC38316.1 - 1.8e-15 57.2 0.0 2.2e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC38316.1 - 3.9e-12 46.4 0.1 5.4e-12 46.0 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC38316.1 - 1e-11 44.9 0.0 1.7e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC38316.1 - 1.1e-06 29.4 0.0 1.3e-06 29.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC38316.1 - 7e-06 26.3 0.2 4e-05 23.8 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC38316.1 - 3.7e-05 23.8 0.0 7.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EFC38316.1 - 6.1e-05 22.6 1.7 0.00018 21.0 1.7 1.9 1 1 0 1 1 1 1 Putative acetyl-transferase FR47 PF08445.10 EFC38316.1 - 0.0003 20.7 0.0 0.00058 19.8 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 EFC38316.1 - 0.00049 19.8 0.0 0.00085 19.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ LRR_5 PF13306.6 EFC38316.1 - 0.0023 17.9 0.5 0.0036 17.3 0.5 1.3 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Acetyltransf_9 PF13527.7 EFC38316.1 - 0.0035 17.4 0.3 0.0091 16.1 0.2 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain zf-P11 PF03854.14 EFC38316.1 - 0.018 14.7 0.2 0.048 13.3 0.2 1.7 1 0 0 1 1 1 0 P-11 zinc finger Mss4 PF04421.13 EFC38316.1 - 0.043 14.0 0.7 0.11 12.6 0.2 1.8 1 1 0 2 2 2 0 Mss4 protein GNAT_acetyltran PF12746.7 EFC38316.1 - 0.045 13.3 0.1 0.085 12.4 0.1 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase LppA PF16708.5 EFC38316.1 - 0.058 13.3 0.0 0.091 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium PNKP_ligase PF16542.5 EFC38316.1 - 0.068 12.7 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain HTH_25 PF13413.6 EFC38317.1 - 0.015 15.1 1.3 0.56 10.1 0.0 3.1 2 1 2 4 4 4 0 Helix-turn-helix domain F-box-like PF12937.7 EFC38317.1 - 0.015 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like Put_Phosphatase PF06888.12 EFC38317.1 - 0.029 13.7 0.5 0.029 13.7 0.5 2.0 2 0 0 2 2 2 0 Putative Phosphatase F-box PF00646.33 EFC38317.1 - 0.04 13.8 0.9 0.062 13.2 0.1 1.7 2 0 0 2 2 2 0 F-box domain PRANC PF09372.10 EFC38317.1 - 0.055 13.8 0.1 0.055 13.8 0.1 2.7 3 1 0 3 3 3 0 PRANC domain Glyco_hydro_79n PF03662.14 EFC38317.1 - 0.083 11.8 0.1 0.12 11.3 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain HD_2 PF12917.7 EFC38317.1 - 0.34 10.7 6.6 0.042 13.6 2.1 1.7 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme CENP-F_leu_zip PF10473.9 EFC38317.1 - 2.2 8.3 21.3 0.14 12.1 3.2 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 EFC38317.1 - 9 6.8 12.3 0.84 10.1 2.3 3.1 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) PCRF PF03462.18 EFC38317.1 - 9.3 6.1 11.9 4e+02 0.7 11.9 2.1 1 1 0 1 1 1 0 PCRF domain DSPc PF00782.20 EFC38319.1 - 4.1e-22 78.4 0.1 4.1e-22 78.4 0.1 3.2 3 1 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Lipase_3 PF01764.25 EFC38319.1 - 1.7e-16 60.4 0.0 4.4e-16 59.0 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Y_phosphatase PF00102.27 EFC38319.1 - 3.6e-05 23.4 0.0 7.9e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF2974 PF11187.8 EFC38319.1 - 0.00062 19.4 0.0 0.0017 17.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) CDKN3 PF05706.12 EFC38319.1 - 0.048 13.3 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Pdase_C33_assoc PF14756.6 EFC38319.1 - 0.06 13.3 0.2 0.19 11.6 0.2 1.9 1 0 0 1 1 1 0 Peptidase_C33-associated domain Init_tRNA_PT PF04179.12 EFC38319.1 - 0.067 13.5 0.1 0.33 11.3 0.0 2.2 2 0 0 2 2 2 0 Rit1 DUSP-like domain HipN PF18253.1 EFC38320.1 - 7.1e-09 35.2 0.1 1.8e-08 33.9 0.1 1.7 1 0 0 1 1 1 1 Hsp70-interacting protein N N-terminal domain TPR_2 PF07719.17 EFC38320.1 - 3.9e-08 32.8 2.9 0.14 12.4 0.3 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38320.1 - 4.3e-08 32.6 6.3 0.11 12.3 1.4 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38320.1 - 4.4e-06 26.7 0.4 0.0026 18.0 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat HECW1_helix PF18436.1 EFC38320.1 - 0.0011 19.1 0.6 0.065 13.3 0.1 3.4 3 0 0 3 3 3 1 Helical box domain of E3 ubiquitin-protein ligase HECW1 STI1 PF17830.1 EFC38320.1 - 0.0036 17.2 0.3 0.016 15.1 0.0 2.3 2 0 0 2 2 2 1 STI1 domain TPR_11 PF13414.6 EFC38320.1 - 0.0047 16.6 6.3 0.017 14.8 0.6 2.4 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.6 EFC38320.1 - 0.0057 17.3 0.1 0.073 13.7 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38320.1 - 0.014 15.6 4.9 0.65 10.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Neur_chan_memb PF02932.16 EFC38320.1 - 1.6 8.8 10.3 0.19 11.7 1.8 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CCDC84 PF14968.6 EFC38320.1 - 4 7.0 13.6 0.074 12.7 3.3 2.1 2 0 0 2 2 2 0 Coiled coil protein 84 NHL PF01436.21 EFC38321.1 - 8e-26 88.7 11.0 8e-05 22.5 0.1 6.7 6 0 0 6 6 6 6 NHL repeat SGL PF08450.12 EFC38321.1 - 8e-10 38.7 1.9 2.5e-06 27.3 0.4 3.0 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC38321.1 - 0.00096 19.3 0.7 0.29 11.3 0.0 3.9 5 0 0 5 5 5 1 Arylesterase DUF5074 PF16819.5 EFC38321.1 - 0.0019 18.2 0.1 0.3 11.1 0.0 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF5074) Lactonase PF10282.9 EFC38321.1 - 0.0038 16.5 0.0 0.33 10.2 0.0 2.8 3 0 0 3 3 3 1 Lactonase, 7-bladed beta-propeller Reg_prop PF07494.11 EFC38321.1 - 0.0056 16.7 4.7 15 6.2 0.0 6.0 4 2 2 6 6 6 1 Two component regulator propeller Str_synth PF03088.16 EFC38321.1 - 0.012 15.7 0.0 18 5.5 0.0 3.7 4 0 0 4 4 4 0 Strictosidine synthase Phytase-like PF13449.6 EFC38321.1 - 0.029 14.3 0.0 8.9 6.2 0.0 3.3 2 1 1 3 3 3 0 Esterase-like activity of phytase TRL PF13146.6 EFC38321.1 - 0.029 14.6 2.9 10 6.5 0.0 3.7 3 0 0 3 3 3 0 TRL-like protein family LVIVD PF08309.11 EFC38321.1 - 0.045 13.1 10.5 0.096 12.0 0.1 4.6 5 0 0 5 5 5 0 LVIVD repeat DUF1571 PF07608.11 EFC38322.1 - 0.011 15.2 0.1 0.015 14.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1571) AF-4 PF05110.13 EFC38322.1 - 0.63 8.0 8.8 0.78 7.8 8.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SNF2_N PF00176.23 EFC38323.1 - 2.9e-28 98.6 0.0 7.8e-28 97.2 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain zf-GRF PF06839.12 EFC38323.1 - 1.4e-14 53.9 29.8 8.9e-11 41.7 4.2 2.9 3 0 0 3 3 3 2 GRF zinc finger Helicase_C PF00271.31 EFC38323.1 - 1.4e-09 38.3 0.4 2.5e-08 34.2 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC38323.1 - 5.4e-06 26.5 0.0 5.4e-06 26.5 0.0 4.1 3 1 0 3 3 3 2 Type III restriction enzyme, res subunit TetR_C_27 PF17935.1 EFC38323.1 - 0.021 14.9 0.4 0.087 12.9 0.0 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RasGEF PF00617.19 EFC38324.1 - 4.7e-46 157.2 10.4 3.3e-45 154.4 2.8 3.5 4 0 0 4 4 4 2 RasGEF domain RasGEF_N PF00618.20 EFC38324.1 - 1.9e-14 53.8 0.4 1.9e-14 53.8 0.4 3.9 3 1 0 3 3 3 1 RasGEF N-terminal motif TPALS PF18178.1 EFC38324.1 - 0.0045 16.4 0.0 0.0084 15.6 0.0 1.3 1 0 0 1 1 1 1 TIR- and PNP-associating SLOG family Macoilin PF09726.9 EFC38325.1 - 0.16 10.5 23.4 0.18 10.3 23.4 1.1 1 0 0 1 1 1 0 Macoilin family PPR_2 PF13041.6 EFC38326.1 - 3.7e-16 59.0 19.8 8e-12 45.2 0.3 6.3 6 1 1 7 7 7 3 PPR repeat family PPR PF01535.20 EFC38326.1 - 4.5e-13 48.5 11.1 2.9e-05 24.0 0.0 6.2 6 0 0 6 6 6 4 PPR repeat PPR_3 PF13812.6 EFC38326.1 - 7.8e-06 25.9 25.5 1.2e-05 25.3 0.3 7.1 6 2 2 8 8 8 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC38326.1 - 7.4e-05 22.4 0.4 7.4e-05 22.4 0.4 5.8 8 0 0 8 8 8 1 PPR repeat PPR_long PF17177.4 EFC38326.1 - 0.00021 20.7 2.1 0.3 10.4 0.0 3.6 2 2 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP DAG_kinase_N PF14513.6 EFC38326.1 - 1.5 9.0 6.2 0.75 10.0 0.3 2.8 3 0 0 3 3 3 0 Diacylglycerol kinase N-terminus RNA_lig_T4_1 PF09511.10 EFC38327.1 - 1.5e-35 123.0 2.9 2.4e-35 122.4 2.9 1.3 1 0 0 1 1 1 1 RNA ligase HPD PF05044.12 EFC38327.1 - 0.016 15.1 2.7 0.4 10.5 0.4 2.7 2 0 0 2 2 2 0 Homeo-prospero domain Mistic PF11458.8 EFC38327.1 - 2.6 8.1 5.6 1.5 8.8 0.3 3.0 3 1 0 3 3 3 0 Membrane-integrating protein Mistic ABC_tran PF00005.27 EFC38328.1 - 7.8e-28 97.7 0.0 1.8e-27 96.5 0.0 1.6 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC38328.1 - 1.9e-07 30.7 0.3 1.8e-05 24.3 0.0 2.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFC38328.1 - 0.00031 20.6 1.0 0.00091 19.1 0.6 1.8 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFC38328.1 - 0.00077 19.5 0.0 0.002 18.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC38328.1 - 0.043 13.6 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFC38328.1 - 0.082 13.4 1.0 0.16 12.5 1.0 1.5 1 1 0 1 1 1 0 AAA domain SNF2_N PF00176.23 EFC38329.1 - 4.3e-40 137.5 0.1 1.3e-39 135.9 0.1 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC38329.1 - 5.2e-16 59.0 0.3 2.2e-15 57.0 0.3 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC38329.1 - 4.2e-14 52.9 7.6 7.2e-14 52.2 0.0 3.7 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFC38329.1 - 5.3e-07 28.8 0.2 1.3e-06 27.6 0.2 1.6 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 SWI2_SNF2 PF18766.1 EFC38329.1 - 2e-06 27.7 0.1 2e-06 27.7 0.1 3.0 3 1 0 3 3 3 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 EFC38329.1 - 4.6e-06 26.0 1.5 4.6e-06 26.0 1.5 2.9 3 0 0 3 3 3 2 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EFC38329.1 - 0.00049 19.4 2.2 0.0022 17.2 2.2 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DUF2716 PF10898.8 EFC38329.1 - 0.39 11.1 6.5 4.3 7.7 0.5 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2716) Pox_A21 PF05323.12 EFC38329.1 - 6.3 7.4 5.7 2.9 8.5 0.3 3.2 3 1 1 4 4 4 0 Poxvirus A21 Protein Coatomer_E PF04733.14 EFC38331.1 - 0.039 13.3 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 Coatomer epsilon subunit EF-hand_1 PF00036.32 EFC38333.1 - 9.1e-28 93.7 17.0 6.4e-09 34.7 0.5 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFC38333.1 - 5.1e-26 90.9 7.2 2e-13 50.6 1.9 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC38333.1 - 2.2e-22 77.0 11.1 4.4e-08 32.4 0.2 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFC38333.1 - 7.3e-21 73.8 11.8 2e-10 40.3 0.9 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EFC38333.1 - 4.7e-13 48.0 14.5 1.4e-06 27.5 0.4 4.6 4 1 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EFC38333.1 - 1.6e-11 44.3 0.1 2.8e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SurA_N_3 PF13624.6 EFC38333.1 - 1e-05 25.4 3.9 0.038 13.8 0.5 2.2 1 1 1 2 2 2 2 SurA N-terminal domain Dockerin_1 PF00404.18 EFC38333.1 - 0.0012 19.0 1.5 6.9 6.9 0.1 3.2 3 0 0 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 EFC38333.1 - 0.0029 17.5 5.8 0.084 12.8 0.2 3.1 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand FlgD PF03963.14 EFC38333.1 - 0.0038 17.5 2.7 0.041 14.2 0.9 2.4 2 1 0 2 2 2 1 Flagellar hook capping protein - N-terminal region SurA_N_2 PF13623.6 EFC38333.1 - 0.0082 16.0 4.0 0.73 9.7 0.3 2.8 1 1 1 2 2 2 2 SurA N-terminal domain EF-hand_14 PF17959.1 EFC38333.1 - 0.0089 16.3 1.7 2.6 8.4 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain DUF3911 PF13050.6 EFC38333.1 - 0.012 15.7 2.8 3.3 7.9 0.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3911) SCF PF02404.15 EFC38333.1 - 0.027 13.8 0.4 0.043 13.1 0.4 1.3 1 0 0 1 1 1 0 Stem cell factor EFhand_Ca_insen PF08726.10 EFC38333.1 - 0.085 13.0 0.4 0.74 9.9 0.1 2.6 3 1 0 3 3 3 0 Ca2+ insensitive EF hand Caleosin PF05042.13 EFC38333.1 - 0.1 12.5 0.8 15 5.5 0.0 3.1 1 1 3 4 4 4 0 Caleosin related protein DUF4093 PF13331.6 EFC38333.1 - 0.11 13.0 0.9 1.7 9.1 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4093) DUF3008 PF11450.8 EFC38333.1 - 0.57 10.4 0.0 0.57 10.4 0.0 2.5 3 0 0 3 3 3 0 Protein of unknwon function (DUF3008) SRI PF08236.11 EFC38333.1 - 0.9 9.8 4.1 1.7 8.9 0.1 2.9 3 1 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain PPR PF01535.20 EFC38334.1 - 0.00079 19.5 0.0 0.18 12.2 0.0 2.6 2 0 0 2 2 2 1 PPR repeat PPR_3 PF13812.6 EFC38334.1 - 0.0016 18.5 0.3 0.0035 17.4 0.1 1.7 2 0 0 2 2 2 1 Pentatricopeptide repeat domain TPR_8 PF13181.6 EFC38334.1 - 0.012 15.7 0.1 0.89 9.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR_2 PF13041.6 EFC38334.1 - 0.03 14.5 0.2 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 PPR repeat family TPR_19 PF14559.6 EFC38334.1 - 0.063 13.8 0.1 0.2 12.2 0.0 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38334.1 - 0.082 13.6 0.2 31 5.5 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat FF PF01846.19 EFC38335.1 - 8.9e-28 96.2 27.9 2.3e-07 30.9 0.3 6.0 6 0 0 6 6 6 5 FF domain WD40 PF00400.32 EFC38336.1 - 3.2e-18 65.7 13.5 0.00066 20.4 0.5 7.8 7 1 0 7 7 7 4 WD domain, G-beta repeat BBS2_Mid PF14783.6 EFC38336.1 - 0.00016 21.7 0.0 0.14 12.2 0.0 2.9 2 1 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EFC38336.1 - 0.00018 21.8 0.7 0.11 12.8 0.1 4.5 3 3 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain AAA-ATPase_like PF09820.9 EFC38337.1 - 3.4e-20 72.6 1.4 6.3e-20 71.7 1.4 1.5 1 0 0 1 1 1 1 Predicted AAA-ATPase Coagulin PF02035.15 EFC38337.1 - 0.21 11.5 1.9 3.6 7.4 0.8 2.3 2 0 0 2 2 2 0 Coagulin RCC1_2 PF13540.6 EFC38338.1 - 3.8e-19 68.0 15.8 1.9e-05 24.3 0.8 6.3 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC38338.1 - 6.1e-18 65.2 0.3 0.0002 21.9 0.1 6.6 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.14 EFC38338.1 - 0.0044 16.8 1.2 4.8 7.1 0.0 3.6 4 0 0 4 4 4 2 Peptidase family C25, C terminal ig-like domain Lipase_GDSL PF00657.22 EFC38339.1 - 1.7e-06 28.1 0.0 3.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EFC38339.1 - 1.9e-06 28.4 0.0 3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family RWP-RK PF02042.15 EFC38340.1 - 5.8e-23 80.6 0.4 1.2e-22 79.5 0.4 1.6 1 0 0 1 1 1 1 RWP-RK domain BTB PF00651.31 EFC38341.1 - 1.4e-11 44.6 0.4 2.2e-11 44.0 0.4 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 EFC38341.1 - 0.0064 16.7 0.2 0.013 15.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Guanylate_cyc PF00211.20 EFC38342.1 - 1.2e-10 41.3 0.8 2.8e-10 40.1 0.8 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain EGF_2 PF07974.13 EFC38343.1 - 3.9e-17 62.3 158.1 2.3e-06 27.9 6.6 12.6 12 0 0 12 12 12 8 EGF-like domain Jacalin PF01419.17 EFC38343.1 - 6.5e-08 32.6 0.4 2.4e-07 30.8 0.4 2.0 1 0 0 1 1 1 1 Jacalin-like lectin domain Orf78 PF06024.12 EFC38343.1 - 2e-05 24.8 0.1 4.4e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Orf78 (ac78) TMEM154 PF15102.6 EFC38343.1 - 0.00043 20.2 0.1 0.0016 18.3 0.1 2.0 1 0 0 1 1 1 1 TMEM154 protein family EGF PF00008.27 EFC38343.1 - 0.0095 16.2 6.0 0.0095 16.2 6.0 9.9 9 1 0 9 9 9 4 EGF-like domain U-box PF04564.15 EFC38344.1 - 4.1e-06 26.9 0.1 1.7e-05 24.9 0.1 2.2 1 0 0 1 1 1 1 U-box domain CotJB PF12652.7 EFC38344.1 - 2.7 8.3 4.4 8 6.8 0.3 3.3 3 0 0 3 3 3 0 CotJB protein SSP160 PF06933.11 EFC38345.1 - 10 4.2 7.7 15 3.6 7.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ADK PF00406.22 EFC38346.1 - 2.9e-36 124.8 0.0 1.1e-35 123.0 0.0 1.9 2 0 0 2 2 2 1 Adenylate kinase AAA_17 PF13207.6 EFC38346.1 - 3.6e-23 82.5 0.1 4.5e-22 78.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFC38346.1 - 5.9e-05 23.6 1.9 0.00075 20.0 0.2 3.4 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFC38346.1 - 0.00032 20.9 0.9 0.0089 16.2 0.9 2.6 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 EFC38346.1 - 0.00052 20.3 0.1 0.33 11.2 0.0 2.4 1 1 1 2 2 2 2 Hydin Adenylate kinase-like domain RRF PF01765.19 EFC38346.1 - 0.02 14.8 0.1 0.069 13.1 0.1 1.9 1 0 0 1 1 1 0 Ribosome recycling factor Thymidylate_kin PF02223.17 EFC38346.1 - 0.031 13.9 0.2 4.7 6.8 0.0 2.8 2 0 0 2 2 2 0 Thymidylate kinase AAA PF00004.29 EFC38346.1 - 0.1 13.0 0.5 0.6 10.5 0.1 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 EFC38346.1 - 0.14 12.4 0.1 0.35 11.1 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC38346.1 - 0.19 12.0 0.5 25 5.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain Radical_SAM PF04055.21 EFC38347.1 - 7e-17 62.3 0.0 1.1e-16 61.7 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily BATS PF06968.13 EFC38347.1 - 0.0051 16.9 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Pkinase PF00069.25 EFC38348.1 - 2.4e-46 158.2 0.2 6.4e-46 156.9 0.2 1.8 1 0 0 1 1 1 1 Protein kinase domain DOCK-C2 PF14429.6 EFC38348.1 - 2.7e-28 99.1 0.3 2.7e-28 99.1 0.3 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins Pkinase_Tyr PF07714.17 EFC38348.1 - 3.5e-27 95.3 3.6 1.5e-25 90.0 0.1 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 EFC38348.1 - 0.012 15.0 0.0 0.072 12.4 0.0 2.3 1 1 0 1 1 1 0 Kinase-like V-set_2 PF15910.5 EFC38348.1 - 0.016 15.3 0.5 0.097 12.8 0.5 2.4 1 0 0 1 1 1 0 ICOS V-set domain APH PF01636.23 EFC38348.1 - 0.06 13.3 0.0 7.8 6.3 0.0 2.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family HSP20 PF00011.21 EFC38349.1 - 3e-23 81.9 0.8 3.5e-23 81.7 0.8 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC38349.1 - 1.4e-05 24.6 0.0 2.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Vps26 PF03643.15 EFC38349.1 - 0.0066 15.5 0.5 0.008 15.2 0.5 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 F-box-like PF12937.7 EFC38350.1 - 1.1e-08 34.9 0.1 3e-08 33.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC38350.1 - 0.0031 17.4 0.2 0.01 15.7 0.2 1.9 1 0 0 1 1 1 1 F-box domain DUF4116 PF13475.6 EFC38352.1 - 1.7e-45 152.5 16.9 4.6e-15 55.1 0.0 7.2 2 2 4 8 8 8 7 Domain of unknown function (DUF4116) DUF3666 PF12408.8 EFC38352.1 - 0.041 13.1 1.8 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Ribose-5-phosphate isomerase Beta_helix PF13229.6 EFC38353.1 - 1e-40 139.2 155.5 1.5e-21 76.9 8.2 10.7 5 4 4 10 10 10 6 Right handed beta helix region Pkinase_Tyr PF07714.17 EFC38353.1 - 7.7e-20 71.3 0.0 1.6e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC38353.1 - 9.4e-17 61.2 0.0 1.9e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain HOCHOB PF17943.1 EFC38353.1 - 0.096 13.4 0.8 3.9 8.2 0.0 3.0 3 0 0 3 3 3 0 Homeobox-cysteine loop-homeobox MFS_1 PF07690.16 EFC38354.1 - 1.3e-15 57.2 25.8 1.3e-15 57.2 25.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC38354.1 - 8.8e-08 31.4 33.0 1.1e-07 31.1 33.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter Bacteriocin_IId PF09221.10 EFC38354.1 - 0.18 12.0 7.9 0.84 9.9 0.4 3.3 3 0 0 3 3 3 0 Bacteriocin class IId cyclical uberolysin-like PARP PF00644.20 EFC38355.1 - 1.1e-26 93.6 2.5 1.1e-26 93.6 2.5 3.0 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Ank_2 PF12796.7 EFC38355.1 - 8.1e-15 55.2 0.1 8.1e-15 55.2 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC38355.1 - 2.3e-11 42.9 0.4 6.9e-05 23.0 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFC38355.1 - 6.3e-11 42.3 0.2 0.00043 20.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC38355.1 - 1.1e-10 41.4 0.3 0.00054 20.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC38355.1 - 8.4e-09 35.8 0.0 0.0011 19.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) RGS PF00615.19 EFC38356.1 - 2.1e-08 34.4 3.3 6.5e-08 32.9 3.3 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 EFC38357.1 - 4.6e-10 39.8 3.1 1e-08 35.4 3.1 2.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain Arrestin_C PF02752.22 EFC38357.1 - 0.061 13.8 0.9 0.13 12.7 0.9 1.5 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain p450 PF00067.22 EFC38358.1 - 2e-83 280.7 0.0 2.3e-83 280.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Exo_endo_phos PF03372.23 EFC38359.1 - 3.4e-06 26.7 0.0 1.8e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Inhibitor_G39P PF11417.8 EFC38360.1 - 0.074 13.6 0.7 0.27 11.8 0.7 2.0 1 1 0 1 1 1 0 Loader and inhibitor of phage G40P GSHPx PF00255.19 EFC38361.1 - 1.3e-41 140.5 1.0 1.8e-41 140.1 1.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EFC38361.1 - 2.5e-09 37.1 0.2 4e-09 36.4 0.2 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC38361.1 - 2.5e-06 27.3 0.2 6.6e-06 25.9 0.2 1.8 1 1 0 1 1 1 1 Redoxin Mistic PF11458.8 EFC38362.1 - 0.038 14.0 0.2 1.3 9.1 0.1 2.9 2 0 0 2 2 2 0 Membrane-integrating protein Mistic Pkinase PF00069.25 EFC38363.1 - 1.1e-44 152.8 0.7 3.5e-44 151.2 0.5 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38363.1 - 2.9e-34 118.5 0.5 1.5e-33 116.2 0.4 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase NHL PF01436.21 EFC38363.1 - 6.1e-18 63.9 4.2 0.00038 20.4 0.0 8.3 8 0 0 8 8 8 4 NHL repeat EGF_2 PF07974.13 EFC38363.1 - 3.1e-12 46.7 123.5 8.3e-06 26.1 9.8 8.8 8 0 0 8 8 8 5 EGF-like domain EGF PF00008.27 EFC38363.1 - 0.00033 20.9 95.6 0.011 16.0 7.9 8.7 9 0 0 9 9 9 5 EGF-like domain SGL PF08450.12 EFC38363.1 - 0.0014 18.3 0.8 0.0042 16.7 0.1 2.3 3 0 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Kdo PF06293.14 EFC38363.1 - 0.0033 16.8 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family hEGF PF12661.7 EFC38363.1 - 0.0055 17.3 8.6 0.0055 17.3 8.6 10.8 12 0 0 12 12 12 3 Human growth factor-like EGF EGF_Tenascin PF18720.1 EFC38363.1 - 0.0096 15.9 3.6 0.0096 15.9 3.6 7.2 6 0 0 6 6 6 1 Tenascin EGF domain Insulin_TMD PF17870.1 EFC38363.1 - 0.2 11.7 1.6 0.66 10.1 1.1 2.1 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment NHL PF01436.21 EFC38364.1 - 6.9e-11 41.6 0.1 0.014 15.4 0.0 4.5 5 0 0 5 5 5 3 NHL repeat Arylesterase PF01731.20 EFC38364.1 - 2.3e-05 24.5 0.1 0.98 9.7 0.0 4.1 2 1 2 4 4 4 2 Arylesterase Lactonase PF10282.9 EFC38364.1 - 0.12 11.6 0.0 5.9 6.0 0.0 2.5 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller DUF5128 PF17170.4 EFC38364.1 - 0.29 10.3 9.2 0.089 11.9 0.3 3.0 1 1 2 3 3 3 0 6-bladed beta-propeller RVP_2 PF08284.11 EFC38366.1 - 0.12 12.1 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease Guanylate_cyc PF00211.20 EFC38368.1 - 8.2e-54 182.0 0.0 1.7e-53 181.0 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38368.1 - 2.1e-12 47.2 0.4 8.4e-12 45.3 0.4 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC38368.1 - 5.7e-09 36.0 0.0 1.5e-08 34.7 0.0 1.7 1 0 0 1 1 1 1 PAS fold Methyltransf_25 PF13649.6 EFC38368.1 - 1.4e-05 25.7 0.0 5.4e-05 23.8 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC38368.1 - 0.0001 22.1 0.0 0.00026 20.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC38368.1 - 0.00015 22.5 0.0 0.00062 20.5 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFC38368.1 - 0.00035 20.1 0.4 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_23 PF13489.6 EFC38368.1 - 0.00052 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC38368.1 - 0.002 17.7 0.0 0.0046 16.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Sec3_C_2 PF15278.6 EFC38368.1 - 0.0058 16.9 0.1 0.041 14.2 0.1 2.5 1 0 0 1 1 1 1 Sec3 exocyst complex subunit Methyltransf_11 PF08241.12 EFC38368.1 - 0.021 15.5 0.0 0.18 12.5 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain HNOBA PF07701.14 EFC38368.1 - 0.38 10.1 2.1 0.68 9.3 0.2 2.2 2 0 0 2 2 2 0 Heme NO binding associated NHL PF01436.21 EFC38369.1 - 4.1e-22 77.0 2.6 9e-06 25.5 0.1 6.5 6 0 0 6 6 6 5 NHL repeat EGF_2 PF07974.13 EFC38369.1 - 6.5e-10 39.2 52.7 5.4e-05 23.5 4.0 4.5 4 0 0 4 4 4 3 EGF-like domain EGF PF00008.27 EFC38369.1 - 7.8e-05 22.9 34.2 0.27 11.6 2.2 4.2 3 0 0 3 3 3 3 EGF-like domain SGL PF08450.12 EFC38369.1 - 0.00044 19.9 0.7 0.13 11.8 0.0 3.8 2 2 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region SdiA-regulated PF06977.11 EFC38369.1 - 0.15 11.3 0.7 4.7 6.4 0.0 2.7 3 0 0 3 3 3 0 SdiA-regulated DUF975 PF06161.11 EFC38370.1 - 0.0047 16.7 0.5 0.0047 16.7 0.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF975) DUF1218 PF06749.12 EFC38370.1 - 0.015 15.8 0.8 0.03 14.8 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) ATLF PF07737.11 EFC38371.1 - 0.021 14.1 0.2 0.026 13.8 0.2 1.2 1 0 0 1 1 1 0 Anthrax toxin lethal factor, N- and C-terminal domain Baculo_LEF5 PF04838.12 EFC38371.1 - 0.053 13.6 0.4 0.075 13.1 0.4 1.4 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 PhoPQ_related PF10142.9 EFC38372.1 - 4e-92 308.7 2.6 7.8e-92 307.7 2.6 1.4 1 1 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein SHS2_FTSA PF02491.20 EFC38373.1 - 0.14 12.6 0.0 1.6 9.2 0.0 2.4 2 0 0 2 2 2 0 SHS2 domain inserted in FTSA Pyr_redox_2 PF07992.14 EFC38374.1 - 1.4e-24 86.9 0.7 2.2e-24 86.2 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC38374.1 - 0.00034 19.8 0.0 0.0017 17.5 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 EFC38374.1 - 0.0012 19.4 0.9 0.37 11.4 0.0 3.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 EFC38374.1 - 0.011 15.6 0.3 0.93 9.5 0.0 3.0 2 0 0 2 2 2 0 Rubredoxin NAD+ reductase C-terminal domain K_oxygenase PF13434.6 EFC38374.1 - 0.017 14.3 0.2 3.9 6.5 0.0 2.9 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) DUF5345 PF17280.2 EFC38374.1 - 1.3 9.1 3.6 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5345) APG12 PF04110.13 EFC38375.1 - 4.6e-25 87.8 0.0 6.1e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 EFC38375.1 - 0.06 13.6 0.0 0.074 13.3 0.0 1.2 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like UBX PF00789.20 EFC38376.1 - 1e-05 25.6 0.3 4.9e-05 23.4 0.1 2.4 2 0 0 2 2 2 1 UBX domain NLRC4_HD PF17889.1 EFC38376.1 - 0.24 11.8 2.5 0.61 10.4 0.5 2.3 2 0 0 2 2 2 0 NLRC4 helical domain Jnk-SapK_ap_N PF09744.9 EFC38376.1 - 3.2 8.0 18.3 1.4 9.2 12.7 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DnaI_N PF07319.11 EFC38376.1 - 4.4 8.0 9.3 0.14 12.8 1.4 2.5 2 1 1 3 3 3 0 Primosomal protein DnaI N-terminus YqaJ PF09588.10 EFC38377.1 - 2.2e-09 37.6 1.4 1.2e-07 32.0 1.4 3.2 1 1 0 1 1 1 1 YqaJ-like viral recombinase domain ACP_syn_III_C PF08541.10 EFC38378.1 - 2.2e-25 88.6 0.2 1.3e-24 86.2 0.0 2.3 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 EFC38378.1 - 3.4e-14 52.4 0.1 3.4e-13 49.2 0.0 2.5 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Chal_sti_synt_N PF00195.19 EFC38378.1 - 1.2e-05 24.9 0.1 2.6e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Chalcone and stilbene synthases, N-terminal domain SpoVAD PF07451.11 EFC38378.1 - 0.0013 17.5 0.1 0.012 14.4 0.0 2.1 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) Thiolase_N PF00108.23 EFC38378.1 - 0.0025 17.2 0.4 0.033 13.5 0.0 2.3 1 1 1 2 2 2 1 Thiolase, N-terminal domain PCMT PF01135.19 EFC38378.1 - 0.093 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PARP PF00644.20 EFC38379.1 - 1.1e-20 74.1 0.1 2.2e-20 73.1 0.1 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain RicinB_lectin_2 PF14200.6 EFC38379.1 - 6.1e-14 52.5 4.1 3e-08 34.3 1.3 2.6 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like VWA PF00092.28 EFC38381.1 - 9.1e-09 35.8 0.3 3e-08 34.1 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC38381.1 - 6.9e-07 29.9 0.1 3.2e-06 27.8 0.1 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.9 EFC38381.1 - 0.00091 19.4 0.1 0.004 17.3 0.0 2.1 2 0 0 2 2 2 1 VWA-like domain (DUF2201) VWA_CoxE PF05762.14 EFC38381.1 - 0.00094 18.6 0.1 0.0018 17.7 0.1 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF2828 PF11443.8 EFC38381.1 - 0.0024 16.1 1.7 0.076 11.1 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF2828) HJURP_C PF12347.8 EFC38381.1 - 0.1 12.6 0.1 0.28 11.3 0.1 1.7 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat Beta_protein PF14350.6 EFC38381.1 - 0.11 11.8 1.6 0.4 10.0 0.4 2.3 2 1 0 2 2 2 0 Beta protein FlxA PF14282.6 EFC38381.1 - 0.13 12.3 2.5 0.31 11.1 0.1 2.7 2 0 0 2 2 2 0 FlxA-like protein LMBR1 PF04791.16 EFC38381.1 - 1.7 7.5 10.8 0.21 10.4 2.6 2.3 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF2607 PF10795.9 EFC38382.1 - 0.019 15.1 0.1 0.066 13.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2607) PgaD PF13994.6 EFC38382.1 - 0.037 14.1 0.2 0.037 14.1 0.2 2.2 3 0 0 3 3 3 0 PgaD-like protein S1FA PF04689.13 EFC38382.1 - 0.29 11.3 2.5 1.1 9.5 0.1 2.7 2 0 0 2 2 2 0 DNA binding protein S1FA Pedibin PF08182.11 EFC38383.1 - 0.41 10.5 1.8 0.91 9.4 1.8 1.6 1 0 0 1 1 1 0 Pedibin/Hym-346 family LRR_4 PF12799.7 EFC38384.1 - 0.13 12.8 15.6 0.94 10.0 0.9 5.8 2 1 5 7 7 7 0 Leucine Rich repeats (2 copies) Tubulin PF00091.25 EFC38385.1 - 7.5e-72 241.7 0.1 3.2e-71 239.6 0.0 1.9 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC38385.1 - 1.9e-36 125.0 0.1 2.9e-36 124.4 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC38385.1 - 3.1e-07 30.7 0.0 6.4e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain cEGF PF12662.7 EFC38385.1 - 0.14 12.1 0.6 0.29 11.1 0.6 1.5 1 0 0 1 1 1 0 Complement Clr-like EGF-like Fn3-like PF14310.6 EFC38386.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 Fibronectin type III-like domain zf-4CXXC_R1 PF10497.9 EFC38388.1 - 2.9e-05 24.2 9.6 0.00011 22.4 9.6 2.0 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 EZH2_WD-Binding PF11616.8 EFC38389.1 - 0.025 14.7 0.4 0.11 12.7 0.4 2.2 1 0 0 1 1 1 0 WD repeat binding protein EZH2 HycH PF07450.11 EFC38389.1 - 0.053 13.9 5.5 0.073 13.5 1.5 2.9 3 0 0 3 3 3 0 Formate hydrogenlyase maturation protein HycH DUF1281 PF06924.11 EFC38389.1 - 0.07 12.7 6.0 4.1 6.9 0.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1281) FAM176 PF14851.6 EFC38389.1 - 2.7 7.6 7.2 7.1 6.3 4.9 2.6 2 0 0 2 2 2 0 FAM176 family EGF_2 PF07974.13 EFC38390.1 - 2.1e-12 47.2 155.5 2.5e-05 24.5 6.6 12.8 11 2 2 13 13 13 8 EGF-like domain EGF PF00008.27 EFC38390.1 - 0.0019 18.5 3.8 0.0019 18.5 3.8 9.9 9 2 0 9 9 9 4 EGF-like domain BpuSI_N PF15516.6 EFC38390.1 - 0.017 15.0 0.6 0.93 9.4 0.1 2.9 2 0 0 2 2 2 0 BpuSI N-terminal domain ANAPC1 PF12859.7 EFC38390.1 - 0.1 13.2 0.0 0.1 13.2 0.0 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 1 DUF3244 PF11589.8 EFC38390.1 - 7.4 6.7 9.6 5.4 7.2 0.7 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3244) F-box-like PF12937.7 EFC38391.1 - 0.023 14.6 0.0 0.049 13.5 0.0 1.5 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC38391.1 - 0.035 14.0 0.0 0.078 12.9 0.0 1.6 1 0 0 1 1 1 0 F-box domain Homeobox_KN PF05920.11 EFC38393.1 - 5e-18 64.7 1.4 5e-18 64.7 1.4 1.8 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFC38393.1 - 7.6e-08 32.1 0.6 1.8e-07 30.9 0.6 1.6 1 0 0 1 1 1 1 Homeodomain FAM176 PF14851.6 EFC38393.1 - 7.2 6.3 9.3 13 5.4 9.3 1.4 1 0 0 1 1 1 0 FAM176 family ADH_zinc_N PF00107.26 EFC38394.1 - 1.3e-24 86.6 0.2 2.6e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC38394.1 - 3.1e-20 73.6 0.0 5.4e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC38394.1 - 5.6e-09 35.9 0.0 1.8e-08 34.2 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFC38394.1 - 0.0047 16.2 0.0 0.0086 15.4 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EFC38394.1 - 0.039 14.4 0.0 0.064 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding BATS PF06968.13 EFC38395.1 - 6.2e-24 84.0 0.0 1.4e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 EFC38395.1 - 1.4e-06 28.8 0.3 4.8e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Sigma70_r4 PF04545.16 EFC38395.1 - 0.049 13.2 1.5 9.1 5.9 0.0 2.7 2 0 0 2 2 2 0 Sigma-70, region 4 MYO10_CC PF16735.5 EFC38395.1 - 0.7 10.0 4.3 1.1 9.4 0.1 2.8 2 0 0 2 2 2 0 Unconventional myosin-X coiled coil domain Aldo_ket_red PF00248.21 EFC38396.1 - 5.7e-78 262.1 0.1 6.4e-78 261.9 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HpuA PF16960.5 EFC38396.1 - 0.02 14.0 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter AhpC-TSA PF00578.21 EFC38397.1 - 0.0043 16.9 0.0 0.0059 16.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family RAP PF08373.10 EFC38398.1 - 0.029 14.4 0.5 0.087 12.9 0.5 1.8 1 0 0 1 1 1 0 RAP domain DUF3989 PF13150.6 EFC38399.1 - 0.41 10.4 0.1 0.41 10.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) Virul_fac_BrkB PF03631.15 EFC38399.1 - 0.8 9.3 31.1 0.014 15.0 8.5 2.9 1 1 1 2 2 2 0 Virulence factor BrkB F-box-like PF12937.7 EFC38400.1 - 0.00045 20.1 0.1 0.00084 19.2 0.1 1.4 1 0 0 1 1 1 1 F-box-like SPRY PF00622.28 EFC38400.1 - 0.0038 17.3 0.2 0.0078 16.3 0.1 1.6 2 0 0 2 2 2 1 SPRY domain F-box PF00646.33 EFC38400.1 - 0.019 14.9 0.0 0.039 13.8 0.0 1.5 1 0 0 1 1 1 0 F-box domain PARP PF00644.20 EFC38401.1 - 2.3e-26 92.6 2.3 2.3e-26 92.6 2.3 2.9 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Ank_2 PF12796.7 EFC38401.1 - 1.1e-25 90.0 0.6 6.7e-14 52.2 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC38401.1 - 4.6e-14 51.1 0.9 0.00089 19.5 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 EFC38401.1 - 5.4e-12 46.0 0.2 9.9e-05 22.8 0.0 3.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC38401.1 - 5.8e-12 45.6 0.1 0.0082 16.4 0.0 3.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC38401.1 - 4.8e-11 42.6 3.7 0.022 15.2 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat ERM PF00769.19 EFC38401.1 - 2 8.1 41.3 0.12 12.2 9.1 3.3 2 1 1 3 3 3 0 Ezrin/radixin/moesin family Spc7 PF08317.11 EFC38401.1 - 6.8 5.5 71.7 0.0076 15.2 20.0 4.2 3 1 0 4 4 4 0 Spc7 kinetochore protein G-alpha PF00503.20 EFC38402.1 - 3.5e-118 394.8 7.5 4.3e-118 394.5 7.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC38402.1 - 2.7e-16 59.5 1.7 2.9e-11 43.1 0.3 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC38402.1 - 7.3e-06 25.5 0.9 0.039 13.3 0.2 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC38402.1 - 0.0064 16.7 4.2 2.3 8.4 0.1 3.4 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC38402.1 - 0.012 15.7 0.0 0.95 9.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC38402.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Wtap PF17098.5 EFC38403.1 - 3e-05 24.0 4.0 3e-05 24.0 4.0 2.3 2 1 0 2 2 2 1 WTAP/Mum2p family SNARE PF05739.19 EFC38403.1 - 3.3e-05 23.8 0.5 9.9e-05 22.3 0.5 1.9 1 0 0 1 1 1 1 SNARE domain DUF885 PF05960.11 EFC38403.1 - 0.00013 21.8 0.0 0.00064 19.5 0.0 1.8 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF885) APG6_N PF17675.1 EFC38403.1 - 0.00029 21.3 20.0 0.0054 17.3 6.0 2.5 2 0 0 2 2 2 2 Apg6 coiled-coil region DUF2207 PF09972.9 EFC38403.1 - 0.0045 15.8 0.3 0.0045 15.8 0.3 2.1 1 1 1 2 2 1 1 Predicted membrane protein (DUF2207) TarH PF02203.15 EFC38403.1 - 0.0055 16.7 4.9 0.17 11.8 0.1 3.3 3 0 0 3 3 3 1 Tar ligand binding domain homologue SKA2 PF16740.5 EFC38403.1 - 0.012 15.4 13.4 0.63 9.8 0.2 3.3 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Sulfatase_C PF14707.6 EFC38403.1 - 0.035 14.8 3.4 1.9 9.2 0.3 2.9 2 2 0 2 2 2 0 C-terminal region of aryl-sulfatase DUF1664 PF07889.12 EFC38403.1 - 0.052 13.6 17.8 0.21 11.6 3.0 3.6 2 2 2 4 4 3 0 Protein of unknown function (DUF1664) Sec20 PF03908.13 EFC38403.1 - 0.053 13.4 0.2 0.053 13.4 0.2 4.0 2 2 0 4 4 4 0 Sec20 DUF1729 PF08354.10 EFC38403.1 - 0.075 11.9 0.2 0.075 11.9 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1729) CYTL1 PF15153.6 EFC38403.1 - 0.088 12.8 2.4 11 6.0 0.1 2.9 3 0 0 3 3 3 0 Cytokine-like protein 1 DUF2721 PF11026.8 EFC38403.1 - 0.096 12.6 0.8 0.48 10.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) TMPIT PF07851.13 EFC38403.1 - 0.12 11.6 16.1 0.069 12.4 5.0 2.6 2 1 0 2 2 2 0 TMPIT-like protein V-SNARE_C PF12352.8 EFC38403.1 - 0.19 12.1 4.9 0.097 13.0 2.1 2.0 2 0 0 2 2 1 0 Snare region anchored in the vesicle membrane C-terminus DUF948 PF06103.11 EFC38403.1 - 0.25 11.6 5.7 15 5.9 0.7 3.8 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1465 PF07323.12 EFC38403.1 - 0.25 11.2 6.7 0.14 12.0 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) BLOC1_2 PF10046.9 EFC38403.1 - 0.48 10.8 13.7 0.25 11.6 0.9 3.7 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAP206 PF12018.8 EFC38403.1 - 0.5 9.8 12.7 0.61 9.6 3.8 2.6 2 1 1 3 3 3 0 Domain of unknown function Hypoth_Ymh PF09509.10 EFC38403.1 - 0.6 10.0 4.2 0.31 10.9 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (Hypoth_ymh) Snapin_Pallidin PF14712.6 EFC38403.1 - 0.74 10.3 14.7 0.9 10.0 3.9 3.4 3 0 0 3 3 3 0 Snapin/Pallidin Laminin_II PF06009.12 EFC38403.1 - 0.81 9.7 13.5 0.19 11.7 2.1 3.1 2 1 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 EFC38403.1 - 0.87 8.4 26.1 1 8.2 8.9 2.5 1 1 0 2 2 2 0 Spc7 kinetochore protein Sec34 PF04136.15 EFC38403.1 - 0.92 9.4 21.9 0.22 11.4 3.6 3.5 2 2 1 3 3 3 0 Sec34-like family KxDL PF10241.9 EFC38403.1 - 1.3 9.3 14.3 1.3 9.3 3.6 3.2 2 1 1 3 3 3 0 Uncharacterized conserved protein SpecificRecomb PF10136.9 EFC38403.1 - 1.9 6.7 5.6 0.44 8.8 2.1 1.6 2 0 0 2 2 2 0 Site-specific recombinase DUF2203 PF09969.9 EFC38403.1 - 2.2 9.0 13.2 1.4 9.7 1.2 3.2 1 1 3 4 4 4 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.12 EFC38403.1 - 2.7 8.7 8.3 7.6 7.2 0.0 3.4 3 2 0 3 3 2 0 SlyX CENP-H PF05837.12 EFC38403.1 - 3.3 8.1 20.4 4.6 7.7 4.4 3.4 2 2 1 3 3 3 0 Centromere protein H (CENP-H) Jnk-SapK_ap_N PF09744.9 EFC38403.1 - 5.4 7.2 22.8 0.11 12.7 5.4 2.9 3 1 0 3 3 2 0 JNK_SAPK-associated protein-1 DUF2935 PF11155.8 EFC38403.1 - 6 7.2 8.0 3.7 7.9 1.7 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) Plk4_PB2 PF18409.1 EFC38403.1 - 6.1 7.6 11.5 1.9 9.2 0.7 3.4 2 2 1 3 3 3 0 Polo-like Kinase 4 Polo Box 2 YlqD PF11068.8 EFC38403.1 - 8 6.8 16.0 4.2 7.8 0.5 3.4 2 2 1 3 3 3 0 YlqD protein Syntaxin_2 PF14523.6 EFC38403.1 - 8.2 6.9 25.5 0.19 12.1 7.6 3.5 3 2 1 4 4 3 0 Syntaxin-like protein Spectrin PF00435.21 EFC38403.1 - 9.9 6.7 17.0 5.6 7.5 0.2 4.0 2 2 2 4 4 4 0 Spectrin repeat G8 PF10162.9 EFC38404.1 - 5.7e-28 97.5 1.7 8e-28 97.0 0.1 2.1 2 0 0 2 2 2 1 G8 domain RGM_C PF06534.13 EFC38404.1 - 1.5e-07 31.1 0.2 3e-07 30.1 0.2 1.5 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus fn3 PF00041.21 EFC38404.1 - 0.00014 22.2 0.4 0.00062 20.1 0.4 2.1 1 0 0 1 1 1 1 Fibronectin type III domain EGF_2 PF07974.13 EFC38404.1 - 0.00072 19.9 66.4 0.00079 19.7 9.1 4.7 5 0 0 5 5 5 3 EGF-like domain EGF_Tenascin PF18720.1 EFC38404.1 - 0.005 16.9 9.6 0.005 16.9 9.6 4.5 4 0 0 4 4 4 2 Tenascin EGF domain DUF4950 PF16308.5 EFC38404.1 - 4.5 7.2 8.2 8.2 6.4 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4950) Insulin_TMD PF17870.1 EFC38404.1 - 6.3 7.0 10.7 17 5.5 10.7 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Glyco_transf_10 PF00852.19 EFC38405.1 - 1.6e-29 102.9 0.0 4.1e-29 101.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term SBP_bac_3 PF00497.20 EFC38406.1 - 8.7e-11 41.7 0.2 1.6e-10 40.8 0.1 1.4 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 WAK PF08488.11 EFC38406.1 - 0.11 13.0 0.7 2.1 8.9 0.1 2.4 2 0 0 2 2 2 0 Wall-associated kinase Choline_transpo PF04515.12 EFC38407.1 - 2e-45 155.4 39.3 2e-45 155.4 39.3 2.6 2 1 0 3 3 3 1 Plasma-membrane choline transporter EPL1 PF10513.9 EFC38407.1 - 0.0066 16.8 1.7 0.021 15.2 1.7 1.8 1 0 0 1 1 1 1 Enhancer of polycomb-like Ycf70 PF17382.2 EFC38407.1 - 0.017 15.5 0.1 0.14 12.6 0.1 2.6 1 0 0 1 1 1 0 Uncharacterized Ycf70-like Pex14_N PF04695.13 EFC38407.1 - 0.58 10.8 5.4 23 5.6 0.0 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CAP PF00188.26 EFC38408.1 - 2.5e-08 34.8 0.0 2.5e-08 34.8 0.0 2.8 2 0 0 2 2 2 1 Cysteine-rich secretory protein family EGF_2 PF07974.13 EFC38408.1 - 6.5e-08 32.8 73.2 0.00036 20.8 13.8 4.5 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 EFC38408.1 - 0.6 10.8 53.4 0.26 12.0 9.1 5.2 4 0 0 4 4 4 0 Human growth factor-like EGF DUF2922 PF11148.8 EFC38408.1 - 2.7 7.8 5.4 0.7 9.7 0.9 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2922) p450 PF00067.22 EFC38409.1 - 1.1e-73 248.6 1.1 1.4e-73 248.2 1.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_6 PF13516.6 EFC38410.1 - 4.5e-22 76.2 23.3 4e-06 26.5 0.1 7.2 7 0 0 7 7 7 6 Leucine Rich repeat LRR_8 PF13855.6 EFC38410.1 - 1.7e-19 69.3 23.3 8.7e-07 28.6 8.9 3.8 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC38410.1 - 9.5e-14 51.3 31.2 5.7e-06 26.6 3.0 5.0 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38410.1 - 5.7e-05 23.1 15.7 1.7 9.5 0.2 6.6 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC38410.1 - 0.00098 18.7 5.6 0.19 11.2 1.8 2.4 1 1 1 2 2 2 2 Leucine-rich repeat NKWYS PF10364.9 EFC38410.1 - 0.0047 17.1 4.1 0.18 11.9 1.0 2.3 1 1 1 2 2 2 2 Putative capsular polysaccharide synthesis protein DUF5471 PF17565.2 EFC38410.1 - 0.079 13.3 0.6 0.31 11.3 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5471) DUF424 PF04242.13 EFC38410.1 - 0.28 11.5 3.4 2.8 8.3 0.1 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF424) HALZ PF02183.18 EFC38411.1 - 0.076 13.2 3.0 0.17 12.1 3.0 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper BTB PF00651.31 EFC38413.1 - 1.7e-06 28.2 0.8 1e-05 25.7 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain DUF2247 PF10004.9 EFC38413.1 - 0.025 14.3 4.5 0.037 13.8 0.1 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) Trypan_PARP PF05887.11 EFC38414.1 - 6.9e-09 35.8 80.0 2.9e-05 24.0 34.6 2.9 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) Aminotran_5 PF00266.19 EFC38415.1 - 0.0023 16.9 0.0 0.0046 15.9 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class-V Folate_carrier PF01770.18 EFC38415.1 - 0.11 11.2 0.2 0.12 11.1 0.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier SPOUT_MTase PF02590.17 EFC38415.1 - 0.13 12.3 1.0 12 5.9 0.3 2.1 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase GET2 PF08690.10 EFC38415.1 - 0.16 11.7 6.0 0.2 11.3 6.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 MOSC PF03473.17 EFC38416.1 - 4.5e-21 75.2 0.0 6.8e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 MOSC domain Dicer_dimer PF03368.14 EFC38417.1 - 0.064 13.4 0.2 0.12 12.5 0.2 1.5 1 0 0 1 1 1 0 Dicer dimerisation domain BSP_II PF05432.11 EFC38417.1 - 3.1 7.4 19.8 0.028 14.1 10.9 1.8 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) DUF5578 PF17741.1 EFC38418.1 - 1.2e-19 70.8 3.6 1.6e-19 70.4 0.1 2.3 2 0 0 2 2 2 1 Family of unknown function (DUF5578) Peptidase_M1 PF01433.20 EFC38418.1 - 0.0089 15.6 0.3 0.0089 15.6 0.3 2.1 1 1 1 2 2 2 1 Peptidase family M1 domain Hamartin PF04388.12 EFC38418.1 - 0.056 12.1 14.7 0.073 11.7 14.7 1.1 1 0 0 1 1 1 0 Hamartin protein LRR_9 PF14580.6 EFC38420.1 - 1e-08 34.9 0.3 1.7e-08 34.2 0.3 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC38420.1 - 0.00015 22.1 3.3 0.0016 18.8 0.5 2.7 2 2 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38420.1 - 0.14 11.9 1.7 2.7 7.8 0.9 2.7 2 1 0 2 2 2 0 Leucine rich repeat Glyco_tran_WecB PF03808.13 EFC38420.1 - 0.16 11.9 0.0 0.19 11.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family MT PF12777.7 EFC38421.1 - 0.014 14.4 0.5 0.019 14.0 0.5 1.1 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor DUF4061 PF13270.6 EFC38421.1 - 0.089 13.1 3.2 0.4 11.0 3.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4061) DUF883 PF05957.13 EFC38421.1 - 0.14 12.8 0.5 0.62 10.7 0.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Prominin PF05478.11 EFC38421.1 - 0.17 9.8 2.7 0.23 9.4 2.7 1.1 1 0 0 1 1 1 0 Prominin YabA PF06156.13 EFC38421.1 - 0.21 12.2 5.2 0.52 11.0 3.0 2.2 2 0 0 2 2 2 0 Initiation control protein YabA DUF3552 PF12072.8 EFC38421.1 - 0.32 10.4 6.4 0.64 9.4 6.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) V_ATPase_I PF01496.19 EFC38421.1 - 2.8 5.8 7.9 1.3 6.9 5.4 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM76 PF16046.5 EFC38421.1 - 5.5 6.2 10.6 8.8 5.6 10.6 1.4 1 0 0 1 1 1 0 FAM76 protein EF-hand_1 PF00036.32 EFC38422.1 - 4.8e-25 85.2 14.8 1.1e-07 30.9 0.0 4.9 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 EFC38422.1 - 6.3e-21 72.9 14.5 6.2e-08 31.8 0.1 4.8 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EFC38422.1 - 1.3e-20 71.5 10.3 1e-05 25.0 0.1 4.8 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 EFC38422.1 - 5.6e-18 65.2 10.8 2e-13 50.6 0.4 3.5 2 1 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 EFC38422.1 - 1.1e-14 54.0 13.3 1e-08 34.9 0.1 3.8 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC38422.1 - 1.3e-05 25.4 1.7 0.0031 17.8 0.1 3.0 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC38422.1 - 0.00017 21.5 6.5 0.7 9.9 0.0 4.1 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFC38422.1 - 0.0038 17.5 0.2 2.9 8.3 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain Sec23_trunk PF04811.15 EFC38423.1 - 0.011 15.3 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain SGL PF08450.12 EFC38423.1 - 0.077 12.6 0.0 2.9 7.4 0.0 2.1 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Methyltransf_16 PF10294.9 EFC38424.1 - 6.9e-12 45.4 0.3 8.1e-11 42.0 0.3 2.0 1 1 0 1 1 1 1 Lysine methyltransferase DUF3721 PF12518.8 EFC38424.1 - 0.093 12.6 0.1 0.23 11.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function Cpn60_TCP1 PF00118.24 EFC38425.1 - 2.2e-85 287.1 5.9 2.6e-85 286.9 5.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HTH_40 PF14493.6 EFC38425.1 - 0.077 13.5 0.7 0.57 10.7 0.2 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain Prefoldin_2 PF01920.20 EFC38427.1 - 3.9e-07 30.0 12.1 5.2e-07 29.6 12.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit RVT_3 PF13456.6 EFC38427.1 - 0.32 10.8 2.0 0.46 10.3 0.1 1.9 2 0 0 2 2 2 0 Reverse transcriptase-like Ly49 PF08391.10 EFC38427.1 - 1.2 9.5 7.7 0.67 10.3 0.8 2.1 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region Translin PF01997.16 EFC38428.1 - 4.2e-51 173.9 1.7 5.6e-51 173.4 1.7 1.2 1 0 0 1 1 1 1 Translin family FXMRP1_C_core PF12235.8 EFC38428.1 - 0.039 14.6 3.8 0.067 13.8 3.8 1.3 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Ric8 PF10165.9 EFC38428.1 - 0.059 12.4 0.7 0.12 11.4 0.7 1.5 1 1 0 1 1 1 0 Guanine nucleotide exchange factor synembryn PRP1_N PF06424.12 EFC38428.1 - 0.068 13.6 1.1 0.14 12.6 1.1 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal SCVP PF17619.2 EFC38428.1 - 4 8.4 5.7 25 5.8 0.3 3.2 3 1 0 3 3 3 0 Secreted clade V proteins PrmA PF06325.13 EFC38429.1 - 1.1e-10 41.4 0.0 1.6e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 EFC38429.1 - 4.5e-09 36.1 0.2 1.3e-05 24.8 0.2 2.2 1 1 1 2 2 2 2 Methyltransferase small domain Cons_hypoth95 PF03602.15 EFC38429.1 - 1.1e-08 35.0 0.1 1.8e-06 27.7 0.1 2.2 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 EFC38429.1 - 3.6e-06 27.6 0.2 1e-05 26.1 0.2 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC38429.1 - 5.1e-06 26.3 1.3 9.7e-06 25.5 1.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC38429.1 - 0.00012 21.9 0.0 0.00024 21.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 EFC38429.1 - 0.00063 19.5 0.8 0.0011 18.7 0.2 1.7 2 1 0 2 2 2 1 Lysine methyltransferase UPF0020 PF01170.18 EFC38429.1 - 0.0017 18.1 0.2 0.1 12.3 0.2 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MetW PF07021.12 EFC38429.1 - 0.003 17.2 0.7 0.0054 16.3 0.7 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_11 PF08241.12 EFC38429.1 - 0.014 16.1 0.0 0.029 15.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 EFC38429.1 - 0.017 15.3 0.0 0.024 14.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_12 PF08242.12 EFC38429.1 - 0.028 15.2 0.3 0.13 13.1 0.3 2.1 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFC38429.1 - 0.034 14.1 0.1 0.071 13.1 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain zf-C4H2 PF10146.9 EFC38429.1 - 0.069 13.5 0.3 0.13 12.6 0.3 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein PCMT PF01135.19 EFC38429.1 - 0.092 12.5 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) OAM_alpha PF16552.5 EFC38429.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 D-ornithine 4,5-aminomutase alpha-subunit Pkinase PF00069.25 EFC38430.1 - 1.1e-44 152.8 0.3 1.7e-44 152.2 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38430.1 - 4.5e-26 91.7 0.1 6.4e-26 91.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC38430.1 - 0.008 15.6 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC38430.1 - 0.018 13.9 0.0 0.029 13.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ion_trans PF00520.31 EFC38433.1 - 1.8e-10 40.4 12.8 1.8e-10 40.4 12.8 2.3 2 0 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 EFC38433.1 - 4.8e-10 38.7 13.3 4.8e-10 38.7 13.3 1.7 2 0 0 2 2 2 1 Polycystin cation channel DUF3989 PF13150.6 EFC38433.1 - 0.02 14.6 0.9 0.05 13.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) Reticulon PF02453.17 EFC38433.1 - 1.4 8.9 10.6 3 7.8 0.3 3.4 3 0 0 3 3 3 0 Reticulon WD40 PF00400.32 EFC38435.1 - 9.6e-22 76.9 12.1 0.00031 21.5 0.1 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC38435.1 - 3.3e-10 40.1 0.4 0.14 12.5 0.0 5.9 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC38435.1 - 0.00027 20.9 0.1 2.8 7.8 0.0 3.5 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_Mid PF14783.6 EFC38435.1 - 0.0008 19.4 0.3 0.47 10.5 0.0 3.4 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 EFC38435.1 - 0.0019 17.2 0.0 0.97 8.3 0.0 2.9 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 EFC38435.1 - 0.14 12.2 0.0 2.1 8.4 0.0 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat WD40_like PF17005.5 EFC38435.1 - 0.2 11.0 6.7 7.8 5.7 0.1 3.6 3 1 0 3 3 3 0 WD40-like domain Hira PF07569.11 EFC38435.1 - 0.3 10.8 1.1 19 4.9 0.0 2.8 3 0 0 3 3 3 0 TUP1-like enhancer of split PsaF PF17550.2 EFC38438.1 - 0.083 12.4 0.3 0.16 11.5 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function ALMT PF11744.8 EFC38439.1 - 2.5 6.8 9.2 3.4 6.4 9.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter FAD_binding_3 PF01494.19 EFC38441.1 - 4.1e-06 26.3 0.1 0.037 13.3 0.1 2.9 1 1 1 2 2 2 2 FAD binding domain Thi4 PF01946.17 EFC38441.1 - 0.0033 16.7 0.0 0.009 15.3 0.0 1.7 2 0 0 2 2 2 1 Thi4 family Mqo PF06039.15 EFC38441.1 - 0.043 12.4 0.0 0.06 11.9 0.0 1.2 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Pyr_redox_3 PF13738.6 EFC38441.1 - 0.052 12.8 0.1 0.11 11.8 0.1 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC38441.1 - 0.052 13.1 0.0 0.078 12.5 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC38441.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ephrin_rec_like PF07699.13 EFC38442.1 - 0.0052 16.5 7.7 0.0052 16.5 7.7 3.3 1 1 2 3 3 3 1 Putative ephrin-receptor like DIM PF08194.12 EFC38442.1 - 0.51 10.6 3.4 1.1 9.5 3.4 1.6 1 0 0 1 1 1 0 DIM protein TNFR_c6 PF00020.18 EFC38442.1 - 1.2 9.6 10.9 0.8 10.2 1.6 2.9 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region Cupin_5 PF06172.11 EFC38444.1 - 4e-34 117.8 0.0 9.5e-34 116.6 0.0 1.6 1 1 0 1 1 1 1 Cupin superfamily (DUF985) BTB PF00651.31 EFC38445.1 - 5.4e-17 62.0 5.8 1.2e-09 38.4 0.8 4.5 3 1 0 3 3 3 2 BTB/POZ domain Kelch_4 PF13418.6 EFC38445.1 - 3.8e-10 39.6 0.2 2.4e-06 27.4 0.0 3.0 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC38445.1 - 3.2e-09 36.5 0.2 7.7e-05 22.6 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 EFC38445.1 - 4e-05 23.7 0.1 0.12 12.7 0.0 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFC38445.1 - 4.6e-05 23.6 0.0 0.0089 16.3 0.0 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC38445.1 - 5.5e-05 23.0 0.9 0.0027 17.6 0.2 2.7 2 0 0 2 2 2 1 Kelch motif Yippee-Mis18 PF03226.14 EFC38446.1 - 1.6e-21 76.5 0.0 2.9e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Fez1 PF06818.15 EFC38446.1 - 0.042 14.3 2.3 0.071 13.6 2.3 1.3 1 0 0 1 1 1 0 Fez1 RIG-I_C-RD PF11648.8 EFC38446.1 - 0.056 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 C-terminal domain of RIG-I Spectrin PF00435.21 EFC38446.1 - 0.16 12.5 2.6 0.28 11.7 1.8 1.7 1 1 0 1 1 1 0 Spectrin repeat TFIIS_C PF01096.18 EFC38446.1 - 0.31 10.9 0.1 0.31 10.9 0.1 1.7 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) ECH_1 PF00378.20 EFC38447.1 - 2.3e-40 138.5 0.0 2.9e-38 131.6 0.0 2.0 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC38447.1 - 2.9e-21 76.4 0.0 9.8e-17 61.4 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase PknG_rubred PF16919.5 EFC38448.1 - 0.89 9.7 0.0 0.89 9.7 0.0 3.5 4 0 0 4 4 4 0 Protein kinase G rubredoxin domain Cnn_1N PF07989.11 EFC38449.1 - 0.032 14.4 0.8 0.094 12.9 0.8 1.7 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 TMF_DNA_bd PF12329.8 EFC38449.1 - 0.14 12.2 3.8 0.43 10.6 3.8 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Ribosomal_L31 PF01197.18 EFC38449.1 - 2.3 8.5 10.6 4 7.7 0.8 3.4 2 1 0 2 2 2 0 Ribosomal protein L31 PX PF00787.24 EFC38450.1 - 8.5e-10 38.6 1.0 8.5e-10 38.6 1.0 2.8 3 0 0 3 3 3 1 PX domain DUF2543 PF10820.8 EFC38450.1 - 0.024 14.8 0.2 0.11 12.7 0.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2543) DUF2603 PF10788.9 EFC38450.1 - 0.07 13.2 2.1 0.081 13.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2603) Peptidase_M75 PF09375.10 EFC38450.1 - 0.27 10.7 1.9 0.3 10.5 0.1 1.9 2 0 0 2 2 2 0 Imelysin DASH_Dad2 PF08654.10 EFC38450.1 - 0.34 11.4 5.5 0.15 12.5 0.4 3.1 4 0 0 4 4 4 0 DASH complex subunit Dad2 VWD PF00094.25 EFC38452.1 - 9.5e-07 29.2 1.0 1.6e-06 28.4 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type D domain DUF1805 PF08827.11 EFC38452.1 - 3.2 8.2 8.5 0.68 10.3 1.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1805) zf-RING_6 PF14835.6 EFC38453.1 - 0.0074 16.1 7.8 0.024 14.5 7.8 1.8 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 EFC38453.1 - 0.014 15.6 9.0 0.034 14.3 8.5 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFC38453.1 - 0.016 15.1 11.1 0.025 14.4 11.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Malectin_like PF12819.7 EFC38453.1 - 0.016 14.4 0.2 0.019 14.2 0.2 1.1 1 0 0 1 1 1 0 Malectin-like domain zf-RING_UBOX PF13445.6 EFC38453.1 - 0.026 14.5 6.3 0.047 13.7 6.1 1.6 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_10 PF16685.5 EFC38453.1 - 0.095 12.9 8.2 0.16 12.1 8.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-C3HC4 PF00097.25 EFC38453.1 - 0.23 11.3 11.8 0.4 10.6 11.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC38453.1 - 0.4 10.7 10.9 1.1 9.3 11.1 1.6 1 1 1 2 2 2 0 zinc-RING finger domain zf-P11 PF03854.14 EFC38453.1 - 6 6.6 14.8 15 5.4 14.8 1.7 1 1 0 1 1 1 0 P-11 zinc finger zf-B_box PF00643.24 EFC38454.1 - 1.9e-11 43.9 23.2 1.4e-08 34.7 5.5 2.4 2 0 0 2 2 2 2 B-box zinc finger zf-C2H2_11 PF16622.5 EFC38454.1 - 8.1 6.3 10.2 3.5e+02 1.1 10.2 2.8 1 1 0 1 1 1 0 zinc-finger C2H2-type E1-E2_ATPase PF00122.20 EFC38455.1 - 1.1e-43 148.9 1.2 1.1e-43 148.9 1.2 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC38455.1 - 6.8e-42 144.1 0.6 1.1e-41 143.4 0.6 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFC38455.1 - 7e-09 36.0 0.4 6.5e-08 32.9 0.1 2.4 2 0 0 2 2 2 1 Heavy-metal-associated domain HAD PF12710.7 EFC38455.1 - 6.1e-05 23.5 0.0 0.00019 21.9 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC38455.1 - 0.001 18.8 13.4 0.014 15.1 0.1 3.9 3 1 0 4 4 4 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFC38455.1 - 0.014 15.5 0.1 0.014 15.5 0.1 2.6 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Macoilin PF09726.9 EFC38455.1 - 9.6 4.6 20.1 15 4.0 20.1 1.2 1 0 0 1 1 1 0 Macoilin family Form_Nir_trans PF01226.17 EFC38456.1 - 7.1e-67 225.2 21.4 8.9e-67 224.9 21.4 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter 2OG-FeII_Oxy_3 PF13640.6 EFC38457.1 - 1.7e-11 44.8 0.0 3.6e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFC38457.1 - 2.1e-05 23.8 0.0 5.7e-05 22.4 0.0 1.7 1 1 0 1 1 1 1 Poxvirus C4/C10 protein PRANC PF09372.10 EFC38457.1 - 0.0071 16.7 1.7 0.024 15.0 1.2 2.1 1 1 0 1 1 1 1 PRANC domain F-box PF00646.33 EFC38457.1 - 0.01 15.7 0.8 0.021 14.7 0.8 1.6 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC38457.1 - 0.015 15.2 0.3 0.044 13.7 0.3 1.9 1 0 0 1 1 1 0 F-box-like F-box_4 PF15966.5 EFC38457.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 F-box Kelch_6 PF13964.6 EFC38458.1 - 0.0032 17.7 0.1 0.012 15.8 0.1 1.9 2 0 0 2 2 2 1 Kelch motif Mut7-C PF01927.16 EFC38458.1 - 2.1 8.5 5.6 4.5 7.4 0.6 2.4 2 0 0 2 2 2 0 Mut7-C RNAse domain Metallophos PF00149.28 EFC38460.1 - 4.4e-21 76.3 1.9 6.8e-21 75.7 1.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC38460.1 - 4.8e-05 23.6 0.1 0.00049 20.3 0.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD PF09423.10 EFC38460.1 - 0.0011 18.1 1.9 0.42 9.6 0.3 2.2 2 0 0 2 2 2 2 PhoD-like phosphatase RCC1_2 PF13540.6 EFC38461.1 - 1.9e-06 27.5 2.4 0.016 15.0 0.1 2.8 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat DUF3870 PF12986.7 EFC38461.1 - 0.025 14.8 0.5 30 4.9 0.0 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3870) RCC1 PF00415.18 EFC38461.1 - 0.38 11.4 1.0 39 5.0 0.0 3.5 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat RNA_pol_Rpb2_6 PF00562.28 EFC38462.1 - 1.4e-106 356.9 0.1 3.7e-106 355.5 0.1 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_3 PF04565.16 EFC38462.1 - 9.4e-23 80.2 0.1 2.1e-22 79.1 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 EFC38462.1 - 7.5e-21 74.3 0.1 2e-20 72.9 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_1 PF04563.15 EFC38462.1 - 3.8e-13 49.4 0.0 4.7e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpa2_4 PF06883.12 EFC38462.1 - 3.5e-12 46.1 0.0 8.6e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 EFC38462.1 - 0.00033 20.3 0.1 0.0036 17.0 0.1 2.5 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 EFC38462.1 - 0.0024 18.1 0.0 0.007 16.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 Ribosomal_L17 PF01196.19 EFC38462.1 - 0.18 12.7 0.0 0.8 10.6 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L17 G-alpha PF00503.20 EFC38463.1 - 6.4e-35 120.9 0.0 8e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_21 PF13304.6 EFC38463.1 - 0.011 15.6 0.1 0.014 15.3 0.1 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFC38463.1 - 0.016 14.9 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFC38463.1 - 0.031 14.8 0.2 0.043 14.3 0.3 1.5 1 1 0 1 1 1 0 ABC transporter Luteo_coat PF00894.18 EFC38463.1 - 0.045 13.6 0.1 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Luteovirus coat protein AAA_29 PF13555.6 EFC38463.1 - 0.048 13.4 0.1 0.091 12.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Amidohydro_2 PF04909.14 EFC38467.1 - 1.8e-62 211.8 0.0 2e-62 211.6 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase 4HBT_2 PF13279.6 EFC38468.1 - 3.8e-13 50.0 0.0 5.1e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 EFC38468.1 - 7.6e-05 22.1 0.9 0.00023 20.5 0.4 1.9 2 0 0 2 2 2 1 Acyl-ACP thioesterase 4HBT PF03061.22 EFC38468.1 - 0.027 14.8 0.0 0.048 14.0 0.0 1.3 1 0 0 1 1 1 0 Thioesterase superfamily RasGEF PF00617.19 EFC38469.1 - 8.7e-31 107.5 5.4 2.2e-30 106.1 5.1 1.9 2 0 0 2 2 2 1 RasGEF domain Gag_spuma PF03276.14 EFC38469.1 - 0.16 10.4 0.0 0.23 9.8 0.0 1.1 1 0 0 1 1 1 0 Spumavirus gag protein Tim54 PF11711.8 EFC38469.1 - 0.18 10.5 3.0 0.33 9.7 3.0 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CENP-B_dimeris PF09026.10 EFC38469.1 - 0.59 10.6 11.7 1.5 9.3 11.7 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CobT PF06213.12 EFC38469.1 - 0.69 9.3 10.4 1.4 8.2 10.4 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 EFC38469.1 - 1.3 8.2 9.9 2.3 7.4 9.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MPM1 PF17234.2 EFC38469.1 - 1.4 9.2 8.7 1.7 8.9 4.7 2.5 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 DUF4820 PF16091.5 EFC38469.1 - 1.6 8.1 5.0 3.2 7.1 5.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Nop14 PF04147.12 EFC38469.1 - 1.6 6.8 15.9 3 5.9 15.9 1.3 1 0 0 1 1 1 0 Nop14-like family MMR_HSR1 PF01926.23 EFC38470.1 - 6.6e-07 29.4 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC38470.1 - 6.7e-07 29.4 0.4 0.0091 15.9 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC38470.1 - 1.2e-05 25.0 0.6 0.0016 18.0 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 EFC38470.1 - 0.00014 22.2 0.1 0.00047 20.5 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Septin PF00735.18 EFC38470.1 - 0.00048 19.5 0.1 0.00099 18.5 0.0 1.6 1 1 0 1 1 1 1 Septin AAA_22 PF13401.6 EFC38470.1 - 0.0021 18.3 0.1 0.033 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC38470.1 - 0.0047 17.3 0.0 0.0069 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFC38470.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 EFC38470.1 - 0.039 13.1 0.0 0.095 11.9 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 EFC38470.1 - 0.057 14.0 0.0 0.13 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 EFC38470.1 - 0.061 13.7 0.1 0.26 11.7 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFC38470.1 - 0.063 12.8 0.3 0.13 11.8 0.1 1.6 1 1 1 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 EFC38470.1 - 0.084 12.6 0.0 0.2 11.3 0.0 1.6 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 EFC38470.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 EFC38470.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Roc PF08477.13 EFC38470.1 - 0.13 12.4 0.4 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GREB1 PF15782.5 EFC38471.1 - 3.2e-18 64.4 35.5 4e-09 34.3 0.0 5.2 5 0 0 5 5 5 4 Gene regulated by oestrogen in breast cancer DDHD PF02862.17 EFC38471.1 - 0.039 14.1 8.3 1.4 9.0 7.9 2.9 2 0 0 2 2 2 0 DDHD domain SF3A3 PF16837.5 EFC38471.1 - 1.1 9.8 5.0 1.1 9.8 1.8 2.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Presenilin PF01080.17 EFC38471.1 - 1.8 7.3 15.3 3.2 6.4 15.3 1.3 1 0 0 1 1 1 0 Presenilin TEX19 PF15553.6 EFC38471.1 - 3.3 7.7 10.0 3.3 7.7 0.2 2.6 2 0 0 2 2 2 0 Testis-expressed protein 19 SWI-SNF_Ssr4 PF08549.10 EFC38471.1 - 3.7 6.1 15.9 6.4 5.3 15.9 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) LcrG PF07216.12 EFC38472.1 - 0.027 14.4 0.7 0.027 14.4 0.7 2.3 2 0 0 2 2 2 0 LcrG protein LPAM_2 PF13627.6 EFC38474.1 - 0.68 9.8 4.8 1.6 8.7 4.8 1.6 1 0 0 1 1 1 0 Prokaryotic lipoprotein-attachment site CytochromB561_N PF09786.9 EFC38475.1 - 6.8e-16 58.4 16.8 2.9e-15 56.3 16.8 2.0 1 1 0 1 1 1 1 Cytochrome B561, N terminal Secretin_N_2 PF07655.13 EFC38476.1 - 0.017 15.7 3.0 0.017 15.7 3.0 5.3 4 1 0 4 4 4 0 Secretin N-terminal domain ASH PF15780.5 EFC38478.1 - 1.8e-07 31.2 13.6 0.0081 16.3 0.2 6.9 6 1 1 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 EFC38478.1 - 0.00012 22.1 0.2 0.33 11.1 0.1 3.4 4 0 0 4 4 4 2 Flagellar-associated PapD-like ABC_tran_CTD PF16326.5 EFC38478.1 - 0.0077 16.5 4.4 0.026 14.8 4.4 1.9 1 0 0 1 1 1 1 ABC transporter C-terminal domain IMD PF08397.11 EFC38478.1 - 0.09 12.1 3.8 0.057 12.8 1.2 1.9 2 0 0 2 2 2 0 IRSp53/MIM homology domain TMEM131_like PF12371.8 EFC38478.1 - 0.1 12.8 0.0 0.1 12.8 0.0 5.9 6 1 1 7 7 7 0 Transmembrane protein 131-like CLZ PF16526.5 EFC38478.1 - 0.58 10.5 3.5 2.5 8.5 3.5 2.1 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMEM131_like PF12371.8 EFC38479.1 - 0.0044 17.2 1.9 1.3 9.3 0.0 2.4 2 0 0 2 2 2 2 Transmembrane protein 131-like Secretin_N_2 PF07655.13 EFC38479.1 - 0.12 12.9 14.1 0.26 11.9 14.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain CRAL_TRIO PF00650.20 EFC38480.1 - 2.6e-30 105.2 0.0 4e-30 104.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC38480.1 - 0.067 13.4 0.2 0.3 11.3 0.0 2.2 2 1 0 2 2 2 0 CRAL/TRIO, N-terminal domain G-alpha PF00503.20 EFC38481.1 - 3.9e-94 315.7 12.4 4.7e-94 315.4 12.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC38481.1 - 5.3e-16 58.6 0.4 1.4e-10 40.9 0.2 3.1 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EFC38481.1 - 8.4e-06 26.0 0.1 0.059 13.6 0.1 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC38481.1 - 4.7e-05 23.0 1.3 0.0097 15.5 0.3 2.5 2 1 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 EFC38481.1 - 0.0025 17.9 0.1 3 8.0 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC38481.1 - 0.0065 15.9 4.4 0.17 11.2 0.2 2.7 2 2 0 2 2 2 2 Gtr1/RagA G protein conserved region DNA_pol_A_exo1 PF01612.20 EFC38481.1 - 0.0092 15.7 0.7 0.087 12.5 0.1 2.3 1 1 0 2 2 2 1 3'-5' exonuclease ATP_bind_1 PF03029.17 EFC38481.1 - 0.04 13.7 2.7 1.5 8.5 2.7 2.6 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EFC38481.1 - 0.11 12.0 0.1 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B eIF-6 PF01912.18 EFC38482.1 - 6.9e-78 260.6 0.2 9.2e-78 260.2 0.2 1.2 1 0 0 1 1 1 1 eIF-6 family DUF3232 PF11554.8 EFC38483.1 - 8.7 6.7 13.2 4.5 7.7 0.5 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3232) QIL1 PF15884.5 EFC38484.1 - 0.17 12.5 0.9 1.6 9.4 0.1 2.4 1 1 1 2 2 2 0 MICOS complex subunit MIC13, QIL1 p450 PF00067.22 EFC38485.1 - 1.2e-72 245.2 1.8 5.2e-63 213.4 0.3 2.1 2 0 0 2 2 2 2 Cytochrome P450 AAA_11 PF13086.6 EFC38485.1 - 0.044 13.6 2.9 0.11 12.3 2.2 2.0 2 1 0 2 2 2 0 AAA domain FtsH_ext PF06480.15 EFC38485.1 - 0.25 11.7 4.9 9.6 6.6 0.4 2.7 2 0 0 2 2 2 0 FtsH Extracellular RL PF17797.1 EFC38486.1 - 0.063 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 RL domain PLAC8 PF04749.17 EFC38487.1 - 1.6e-08 35.5 23.2 2.1e-08 35.0 23.2 1.4 1 1 0 1 1 1 1 PLAC8 family GP67 PF17634.2 EFC38487.1 - 0.29 11.6 5.7 0.49 10.8 5.7 1.4 1 0 0 1 1 1 0 Gene product 67 WD40 PF00400.32 EFC38488.1 - 6.1e-34 115.5 9.8 0.0099 16.7 0.0 12.5 12 0 0 12 12 12 9 WD domain, G-beta repeat VirDNA-topo-I_N PF09266.10 EFC38488.1 - 0.0014 18.8 1.0 0.0091 16.1 0.3 2.7 1 1 1 2 2 2 1 Viral DNA topoisomerase I, N-terminal BBS2_Mid PF14783.6 EFC38488.1 - 0.0032 17.5 2.9 5.8 7.0 0.2 4.9 5 0 0 5 5 5 1 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 EFC38488.1 - 0.0047 17.2 4.0 17 5.8 0.0 6.2 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain SMRP1 PF15181.6 EFC38488.1 - 0.059 13.0 0.1 0.14 11.8 0.1 1.7 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 Ribosomal_L11 PF00298.19 EFC38489.1 - 1.4e-11 44.8 0.0 2.4e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EFC38489.1 - 0.0039 17.0 0.0 0.0073 16.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain DUF2817 PF10994.8 EFC38490.1 - 6.6e-33 114.5 0.2 1.1e-32 113.9 0.2 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2817) FOXP-CC PF16159.5 EFC38491.1 - 0.12 13.1 0.1 0.21 12.2 0.1 1.4 1 0 0 1 1 1 0 FOXP coiled-coil domain DUF2313 PF10076.9 EFC38491.1 - 0.14 12.0 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2313) Ras PF00071.22 EFC38492.1 - 5.8e-24 84.5 0.1 1.1e-23 83.7 0.1 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38492.1 - 1.3e-10 41.5 0.0 2.7e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC38492.1 - 3.8e-10 39.6 0.1 5.5e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC38492.1 - 5.3e-09 35.8 0.1 9.2e-09 35.0 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC38492.1 - 1.7e-05 24.3 1.2 2.6e-05 23.7 0.2 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFC38492.1 - 0.0001 22.3 0.3 0.62 10.0 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EFC38492.1 - 0.0028 17.7 1.8 0.0077 16.2 1.6 1.9 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EFC38492.1 - 0.0093 16.0 0.2 0.021 14.9 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF494 PF04361.13 EFC38492.1 - 0.011 15.6 0.3 0.045 13.7 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF494) Sacchrp_dh_NADP PF03435.18 EFC38492.1 - 0.043 14.1 0.1 0.091 13.0 0.1 1.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F-box PF00646.33 EFC38492.1 - 0.071 13.0 0.0 0.2 11.6 0.0 1.8 1 0 0 1 1 1 0 F-box domain CM_1 PF07736.11 EFC38492.1 - 0.1 13.0 0.2 0.3 11.5 0.2 1.8 1 0 0 1 1 1 0 Chorismate mutase type I PglD_N PF17836.1 EFC38492.1 - 0.12 13.1 0.6 0.92 10.2 0.0 2.5 2 1 1 3 3 3 0 PglD N-terminal domain CbiA PF01656.23 EFC38492.1 - 1.7 8.7 4.4 6 6.9 0.2 2.4 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain WH2 PF02205.20 EFC38493.1 - 1.2e-07 31.3 0.1 3.3e-07 29.9 0.1 1.8 1 0 0 1 1 1 1 WH2 motif CAP_N PF01213.19 EFC38493.1 - 0.0075 15.8 3.4 0.0075 15.8 3.4 5.5 2 1 2 4 4 4 1 Adenylate cyclase associated (CAP) N terminal RGS PF00615.19 EFC38494.1 - 1.3e-07 31.9 0.8 0.00017 21.8 0.0 2.9 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF900 PF05990.12 EFC38495.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Glyco_hydro_30 PF02055.16 EFC38496.1 - 1.1e-90 304.1 1.3 1.3e-90 303.9 1.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EFC38496.1 - 8.5e-11 41.9 0.0 2.1e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain DUF563 PF04577.14 EFC38497.1 - 1.6e-36 126.4 0.6 2.5e-36 125.8 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) BolA PF01722.18 EFC38498.1 - 1.5e-23 82.9 0.2 1.5e-23 82.9 0.2 1.4 2 0 0 2 2 2 1 BolA-like protein Frankia_peptide PF14407.6 EFC38498.1 - 0.066 13.2 0.5 0.098 12.7 0.5 1.2 1 0 0 1 1 1 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. Corona_NSP4_C PF16348.5 EFC38499.1 - 0.011 16.6 0.2 2.6 8.9 0.1 2.5 2 0 0 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus Alba PF01918.21 EFC38500.1 - 7.9e-19 67.2 0.0 1.6e-18 66.3 0.0 1.5 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 EFC38500.1 - 7.2e-05 22.8 2.3 7.2e-05 22.8 2.3 3.4 3 2 0 3 3 3 1 Rpp20 subunit of nuclear RNase MRP and P Dicty_REP PF05086.12 EFC38500.1 - 0.049 11.6 8.3 0.076 11.0 8.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Serpin PF00079.20 EFC38501.1 - 2.9e-37 128.9 7.0 3.7e-37 128.5 7.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) B2-adapt-app_C PF09066.10 EFC38502.1 - 3.6e-12 46.3 0.6 3.6e-12 46.3 0.6 1.8 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain ArdA PF07275.11 EFC38502.1 - 0.015 15.8 4.0 0.024 15.2 4.0 1.2 1 0 0 1 1 1 0 Antirestriction protein (ArdA) RabGAP-TBC PF00566.18 EFC38502.1 - 0.052 13.2 3.8 0.078 12.6 3.8 1.4 1 0 0 1 1 1 0 Rab-GTPase-TBC domain PhoLip_ATPase_C PF16212.5 EFC38504.1 - 2e-47 162.1 23.2 2e-47 162.1 23.2 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EFC38504.1 - 3.8e-14 53.5 0.0 1.6e-07 31.9 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFC38504.1 - 2.3e-10 40.3 2.8 2.6e-10 40.1 0.0 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFC38504.1 - 4.9e-06 26.5 0.0 3.3e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC38504.1 - 0.0033 17.2 0.6 0.017 14.9 0.0 2.4 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Sgf11 PF08209.11 EFC38505.1 - 0.0014 18.2 0.3 0.0026 17.3 0.3 1.4 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) ResIII PF04851.15 EFC38505.1 - 7.7 6.5 7.7 11 6.0 3.7 3.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit FAM76 PF16046.5 EFC38506.1 - 0.0028 17.0 1.7 0.0028 17.0 1.7 2.6 2 1 1 3 3 3 1 FAM76 protein Prominin PF05478.11 EFC38506.1 - 0.0055 14.7 0.6 0.66 7.9 0.2 2.2 2 0 0 2 2 2 2 Prominin TMEM192 PF14802.6 EFC38506.1 - 0.0097 15.0 0.2 0.015 14.4 0.2 1.3 1 0 0 1 1 1 1 TMEM192 family DUF2183 PF09949.9 EFC38506.1 - 0.042 14.2 1.7 0.38 11.1 0.4 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) APG6_N PF17675.1 EFC38506.1 - 0.049 14.2 0.6 0.1 13.1 0.6 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF16 PF01519.16 EFC38506.1 - 0.049 14.1 0.1 0.14 12.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF16 FlaC_arch PF05377.11 EFC38506.1 - 0.18 12.3 2.3 0.51 10.8 2.3 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) ABC_membrane PF00664.23 EFC38507.1 - 8.6e-58 196.2 14.6 1.2e-57 195.7 14.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC38507.1 - 6e-35 120.7 0.0 1.3e-34 119.6 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC38507.1 - 1.2e-06 28.2 0.1 0.00075 19.0 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC38507.1 - 0.00074 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFC38507.1 - 0.00077 19.7 0.0 0.0021 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC38507.1 - 0.0019 18.6 0.2 0.012 16.0 0.5 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 EFC38507.1 - 0.0021 17.8 3.8 0.011 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EFC38507.1 - 0.0027 17.5 0.0 0.016 15.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain DUF1764 PF08576.10 EFC38507.1 - 0.012 16.4 4.7 0.025 15.5 4.7 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) RsgA_GTPase PF03193.16 EFC38507.1 - 0.016 15.1 0.0 0.044 13.7 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 EFC38507.1 - 0.069 13.2 0.0 0.25 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EFC38507.1 - 0.11 11.3 0.1 0.29 9.9 0.0 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DUF3382 PF11862.8 EFC38507.1 - 0.12 12.6 2.7 1.5 9.1 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3382) SbcCD_C PF13558.6 EFC38507.1 - 0.14 12.4 0.3 0.84 9.9 0.3 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 EFC38507.1 - 0.91 9.3 5.5 1.2 8.9 0.1 2.8 2 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFC38507.1 - 1.1 9.8 0.0 1.1 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain RCC1_2 PF13540.6 EFC38508.1 - 0.0051 16.6 0.0 0.025 14.4 0.0 2.1 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat TPR_2 PF07719.17 EFC38509.1 - 2.6e-17 61.5 11.7 5e-06 26.2 0.0 5.4 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38509.1 - 5.3e-16 57.7 11.2 3.2e-07 29.9 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38509.1 - 2.2e-13 50.3 3.7 3.3e-06 27.3 0.3 2.7 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38509.1 - 3.7e-07 29.8 13.1 0.0039 17.3 0.1 5.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC38509.1 - 1.5e-05 25.6 0.1 0.39 11.4 0.0 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38509.1 - 0.00039 20.9 2.2 2.5 8.9 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC38509.1 - 0.0045 17.5 0.1 0.12 12.9 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC38509.1 - 0.0046 16.9 3.8 1.4 9.1 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC38509.1 - 0.0069 16.6 4.0 0.4 10.9 0.2 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFC38509.1 - 0.0094 16.1 0.1 0.099 12.8 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Chordopox_A30L PF06015.12 EFC38509.1 - 0.048 13.5 3.2 0.14 12.0 0.4 2.6 2 0 0 2 2 2 0 Chordopoxvirus A30L protein F-box PF00646.33 EFC38509.1 - 0.073 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 F-box domain FAM76 PF16046.5 EFC38510.1 - 0.0011 18.4 6.2 0.0018 17.7 6.2 1.3 1 0 0 1 1 1 1 FAM76 protein Cnn_1N PF07989.11 EFC38510.1 - 2.5 8.3 11.4 33 4.7 11.3 2.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 UPF0242 PF06785.11 EFC38511.1 - 0.012 15.8 6.2 0.017 15.2 6.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 EFC38511.1 - 0.094 12.3 1.2 0.11 12.0 1.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MFMR PF07777.11 EFC38511.1 - 0.13 12.8 1.0 0.96 10.0 0.2 2.3 2 0 0 2 2 2 0 G-box binding protein MFMR DUF573 PF04504.14 EFC38511.1 - 0.17 12.6 9.0 12 6.6 6.8 3.2 1 1 1 2 2 2 0 Protein of unknown function, DUF573 FlaC_arch PF05377.11 EFC38511.1 - 0.98 9.9 8.0 0.57 10.6 4.1 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 EFC38511.1 - 1.6 9.3 12.4 0.51 10.8 7.2 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.7 EFC38511.1 - 1.8 8.7 15.8 0.19 11.9 11.2 1.7 2 0 0 2 2 2 0 Tropomyosin like FAM76 PF16046.5 EFC38512.1 - 0.00038 19.9 3.8 0.0006 19.3 3.8 1.3 1 0 0 1 1 1 1 FAM76 protein GPS2_interact PF15784.5 EFC38512.1 - 0.0028 18.1 4.2 0.0061 17.0 4.2 1.6 1 0 0 1 1 1 1 G-protein pathway suppressor 2-interacting domain V-set_2 PF15910.5 EFC38512.1 - 0.056 13.5 3.7 0.057 13.5 0.8 2.4 1 1 1 2 2 2 0 ICOS V-set domain YabA PF06156.13 EFC38512.1 - 0.13 12.9 3.7 0.42 11.3 1.4 2.5 2 0 0 2 2 2 0 Initiation control protein YabA Baculo_LEF-10 PF07206.11 EFC38512.1 - 0.2 11.8 2.6 2.4 8.4 1.2 2.4 1 1 1 2 2 2 0 Baculovirus late expression factor 10 (LEF-10) SlyX PF04102.12 EFC38513.1 - 0.004 17.7 1.2 0.0075 16.9 1.2 1.4 1 0 0 1 1 1 1 SlyX RP-C_C PF11800.8 EFC38513.1 - 0.0076 16.4 0.3 0.011 15.9 0.3 1.3 1 0 0 1 1 1 1 Replication protein C C-terminal region UPF0242 PF06785.11 EFC38513.1 - 0.024 14.7 0.5 0.036 14.2 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EFC38513.1 - 0.051 13.7 2.6 0.082 13.0 2.6 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DivIC PF04977.15 EFC38513.1 - 0.069 12.9 1.1 0.12 12.1 1.1 1.4 1 0 0 1 1 1 0 Septum formation initiator Cofilin_ADF PF00241.20 EFC38514.1 - 2.7e-10 40.1 0.4 1.1e-09 38.2 0.4 2.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ras PF00071.22 EFC38515.1 - 2.2e-19 69.6 0.0 3.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC38515.1 - 9.3e-06 25.2 0.0 1.5e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC38515.1 - 1.3e-05 25.4 0.0 2.5e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC38515.1 - 0.027 14.4 1.2 0.027 14.4 1.2 2.5 3 0 0 3 3 3 0 F-box domain LRR_6 PF13516.6 EFC38516.1 - 4.5e-49 160.3 38.3 1.4e-05 24.8 0.0 15.5 17 0 0 17 17 17 11 Leucine Rich repeat LRR_8 PF13855.6 EFC38516.1 - 1.1e-31 108.4 37.9 6.1e-09 35.5 0.1 6.8 2 2 3 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC38516.1 - 1.9e-24 85.3 42.8 0.00031 21.1 0.3 9.4 2 1 8 12 12 12 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC38516.1 - 3.4e-08 33.2 13.7 0.035 13.6 0.4 4.0 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EFC38516.1 - 4.1e-08 32.7 25.8 30 5.7 0.0 12.6 12 3 1 13 13 13 1 Leucine Rich Repeat DUF5471 PF17565.2 EFC38516.1 - 0.092 13.0 1.0 0.85 10.0 0.0 3.1 4 1 1 5 5 5 0 Family of unknown function (DUF5471) p450 PF00067.22 EFC38517.1 - 1e-75 255.3 0.2 1.1e-75 255.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 Lipoprotein_2 PF00921.17 EFC38517.1 - 0.068 12.7 0.6 0.1 12.1 0.6 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein Shisa PF13908.6 EFC38518.1 - 0.03 14.6 8.9 0.048 13.9 6.6 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Shisa PF13908.6 EFC38519.1 - 0.011 15.9 8.4 0.011 15.9 8.4 1.7 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator ETRAMP PF09716.10 EFC38519.1 - 0.12 12.4 2.4 0.42 10.7 2.4 1.9 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Prominin PF05478.11 EFC38519.1 - 0.78 7.6 8.7 1.2 7.0 8.7 1.2 1 0 0 1 1 1 0 Prominin RIFIN PF02009.16 EFC38519.1 - 0.82 9.5 6.6 1.6 8.6 2.1 2.1 2 0 0 2 2 2 0 Rifin EphA2_TM PF14575.6 EFC38519.1 - 2.3 9.2 5.1 0.63 11.0 1.4 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Gtr1_RagA PF04670.12 EFC38521.1 - 3.9e-79 265.3 0.6 5.2e-79 264.9 0.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFC38521.1 - 1.7e-10 40.6 0.4 3.6e-10 39.6 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EFC38521.1 - 7.7e-08 32.6 0.0 2.4e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC38521.1 - 4.9e-06 26.2 0.2 1.1e-05 25.0 0.0 1.7 2 1 0 2 2 2 1 Ras family SRPRB PF09439.10 EFC38521.1 - 2.7e-05 23.7 0.1 5.4e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EFC38521.1 - 0.019 15.5 0.9 0.053 14.0 0.9 2.1 1 1 0 1 1 1 0 ABC transporter SMC_N PF02463.19 EFC38521.1 - 0.15 11.5 0.0 0.39 10.1 0.0 1.7 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain G-alpha PF00503.20 EFC38521.1 - 0.24 10.5 9.6 0.63 9.1 3.3 2.8 1 1 1 2 2 2 0 G-protein alpha subunit DUF4711 PF15829.5 EFC38522.1 - 0.0098 15.9 0.1 0.017 15.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4711) CRA PF06589.11 EFC38522.1 - 0.06 13.5 0.8 0.19 11.8 0.0 2.1 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) DUF4448 PF14610.6 EFC38522.1 - 0.11 12.2 0.1 0.11 12.2 0.1 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF4448) CbtA PF09490.10 EFC38522.1 - 1 9.1 6.1 1.8 8.2 0.0 2.9 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) DUF5305 PF17231.2 EFC38522.1 - 2.8 7.3 6.1 12 5.2 0.2 3.3 3 1 1 4 4 4 0 Family of unknown function (DUF5305) CYYR1 PF10873.8 EFC38523.1 - 0.0094 16.4 0.1 0.0094 16.4 0.1 2.1 3 0 0 3 3 3 1 Cysteine and tyrosine-rich protein 1 DarT PF14487.6 EFC38523.1 - 0.018 14.9 5.1 0.2 11.5 1.5 2.2 1 1 1 2 2 2 0 ssDNA thymidine ADP-ribosyltransferase, DarT Glyco_hydro_25 PF01183.20 EFC38524.1 - 7.5e-17 62.1 3.1 8.3e-17 61.9 3.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Stevor PF17410.2 EFC38525.1 - 0.035 13.6 0.3 0.035 13.6 0.3 1.5 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame Amastin PF07344.11 EFC38525.1 - 0.14 12.0 0.7 0.25 11.2 0.7 1.3 1 0 0 1 1 1 0 Amastin surface glycoprotein Phage_holin_3_6 PF07332.11 EFC38525.1 - 0.22 11.6 1.8 0.39 10.8 1.8 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DctQ PF04290.12 EFC38525.1 - 0.22 11.4 1.7 0.32 10.9 1.7 1.2 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component TraL PF07178.11 EFC38525.1 - 1.7 9.1 4.6 0.77 10.3 0.6 2.1 1 1 1 2 2 2 0 TraL protein NHL PF01436.21 EFC38526.1 - 2.4e-67 219.8 12.6 2.6e-06 27.2 0.2 13.1 12 0 0 12 12 12 12 NHL repeat SGL PF08450.12 EFC38526.1 - 2.9e-12 46.7 4.6 2.8e-05 23.9 0.5 6.1 4 3 0 5 5 5 4 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC38526.1 - 2.2e-10 40.7 94.6 4.7e-05 23.7 7.5 6.7 7 0 0 7 7 7 5 EGF-like domain SBBP PF06739.11 EFC38526.1 - 9e-09 35.2 31.2 0.064 13.3 3.2 8.3 7 0 0 7 7 7 5 Beta-propeller repeat RcsF PF16358.5 EFC38527.1 - 0.057 13.5 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 RcsF lipoprotein Menin PF05053.13 EFC38528.1 - 2.7 6.2 9.3 4.1 5.7 9.3 1.1 1 0 0 1 1 1 0 Menin EGF_2 PF07974.13 EFC38529.1 - 1.9e-12 47.3 40.2 0.0001 22.6 8.6 3.5 3 0 0 3 3 3 3 EGF-like domain UPF0669 PF17065.5 EFC38529.1 - 4.6e-07 29.8 1.2 2.9e-06 27.2 0.1 2.8 4 0 0 4 4 4 1 Putative cytokine, C6ORF120 LRR_4 PF12799.7 EFC38530.1 - 0.43 11.1 6.4 2.6 8.6 0.2 3.2 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF262 PF03235.14 EFC38531.1 - 3.6e-21 76.4 4.2 4.2e-21 76.1 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF262 G8 PF10162.9 EFC38532.1 - 0.066 13.3 0.0 1.9 8.6 0.0 2.8 3 0 0 3 3 3 0 G8 domain RimK PF08443.11 EFC38533.1 - 1.4e-41 142.1 0.0 2.1e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 EFC38533.1 - 9.9e-14 51.2 2.6 6.5e-06 25.6 0.1 3.4 2 1 2 4 4 4 3 Sugar-transfer associated ATP-grasp GSH-S_ATP PF02955.16 EFC38533.1 - 1.5e-10 40.7 0.0 2.5e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATPgrasp_YheCD PF14398.6 EFC38533.1 - 1.4e-08 34.3 0.2 0.00017 20.9 0.2 3.0 1 1 0 1 1 1 1 YheC/D like ATP-grasp TTL PF03133.15 EFC38533.1 - 2.6e-07 30.1 0.1 0.00079 18.6 0.1 2.3 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATP-grasp_3 PF02655.14 EFC38533.1 - 3.9e-07 30.3 0.1 7.7e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Rimk_N PF18030.1 EFC38533.1 - 6e-07 29.8 0.0 1.4e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 RimK PreATP-grasp domain Synapsin_C PF02750.14 EFC38533.1 - 1.3e-05 24.8 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain ATP-grasp PF02222.22 EFC38533.1 - 0.00035 20.2 0.0 0.00054 19.6 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFC38533.1 - 0.012 15.2 0.0 0.064 12.8 0.0 2.0 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus SBP_bac_3 PF00497.20 EFC38534.1 - 0.00015 21.3 1.5 0.00021 20.8 0.3 1.6 1 1 1 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 RCC1 PF00415.18 EFC38535.1 - 1.2e-31 109.1 3.8 2.7e-07 31.1 0.1 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC38535.1 - 7.3e-20 70.3 21.4 5e-06 26.2 0.4 6.6 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC38535.1 - 4.5e-10 39.3 5.7 0.00017 21.4 0.4 4.9 4 0 0 4 4 4 2 Kelch motif Fibrinogen_C PF00147.18 EFC38535.1 - 0.00019 21.3 0.0 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Kelch_6 PF13964.6 EFC38535.1 - 0.048 14.0 11.8 0.29 11.5 0.0 5.2 6 0 0 6 6 6 0 Kelch motif RloB PF13707.6 EFC38535.1 - 0.13 12.4 0.1 0.22 11.7 0.1 1.3 1 0 0 1 1 1 0 RloB-like protein Ribosomal_S5 PF00333.20 EFC38535.1 - 0.17 11.8 1.1 0.29 11.2 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein S5, N-terminal domain PAP2_C PF14360.6 EFC38536.1 - 3.9e-23 81.8 14.2 3.9e-23 81.8 14.2 2.8 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EFC38536.1 - 3.4e-08 33.3 8.0 3.4e-08 33.3 8.0 2.5 1 1 1 2 2 2 1 PAP2 superfamily CoxIIa PF08113.11 EFC38536.1 - 0.011 15.5 3.4 0.027 14.3 0.4 3.0 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IIa family PAP2_3 PF14378.6 EFC38536.1 - 0.04 13.6 18.4 0.02 14.6 15.0 2.2 1 1 0 1 1 1 0 PAP2 superfamily MFS_1 PF07690.16 EFC38536.1 - 0.28 10.1 17.9 0.053 12.4 4.5 2.1 1 1 0 2 2 2 0 Major Facilitator Superfamily DUF1516 PF07457.11 EFC38536.1 - 0.61 10.3 15.4 0.06 13.6 2.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1516) DUF2157 PF09925.9 EFC38536.1 - 5 6.9 11.7 0.47 10.2 1.8 2.5 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Trypan_PARP PF05887.11 EFC38537.1 - 5.8e-05 23.1 95.4 0.025 14.5 37.7 3.0 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) Ly49 PF08391.10 EFC38539.1 - 0.021 15.2 0.1 0.033 14.5 0.1 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Podoplanin PF05808.11 EFC38539.1 - 0.5 10.5 8.7 0.081 13.0 4.6 1.7 2 0 0 2 2 2 0 Podoplanin TctA PF01970.16 EFC38539.1 - 0.71 8.5 5.2 0.96 8.1 5.2 1.1 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family Glycophorin_A PF01102.18 EFC38539.1 - 0.75 10.0 3.7 0.86 9.9 2.6 1.7 1 1 0 1 1 1 0 Glycophorin A FA_hydroxylase PF04116.13 EFC38540.1 - 2.9e-20 72.9 13.5 2.9e-20 72.9 13.5 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily PTEN_C2 PF10409.9 EFC38540.1 - 0.038 13.7 0.0 0.088 12.6 0.0 1.5 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein LisH PF08513.11 EFC38541.1 - 8.2e-06 25.6 0.9 7e-05 22.6 0.1 2.7 2 0 0 2 2 2 1 LisH WD40 PF00400.32 EFC38541.1 - 1.9 9.5 4.1 6.7 7.8 0.0 3.6 4 0 0 4 4 4 0 WD domain, G-beta repeat Pyr_redox_3 PF13738.6 EFC38542.1 - 0.057 12.7 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFC38542.1 - 0.064 12.5 0.0 5.3 6.2 0.0 2.4 2 0 0 2 2 2 0 FAD binding domain Rtf2 PF04641.12 EFC38543.1 - 3.6e-55 187.1 13.4 4e-55 187.0 13.4 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 EFC38543.1 - 0.0055 16.8 0.2 0.017 15.2 0.0 1.9 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein Flag1_repress PF03614.13 EFC38543.1 - 0.085 12.6 0.2 0.14 12.0 0.2 1.4 1 0 0 1 1 1 0 Repressor of phase-1 flagellin zf-RING_5 PF14634.6 EFC38543.1 - 0.12 12.3 3.7 0.39 10.7 3.7 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-Nse PF11789.8 EFC38543.1 - 0.21 11.4 0.0 0.21 11.4 0.0 3.0 3 1 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit Vps39_2 PF10367.9 EFC38543.1 - 3.8 8.0 7.1 1.7 9.1 0.5 2.7 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 RIF5_SNase_2 PF18189.1 EFC38544.1 - 0.0028 17.5 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 TbRIF5 SNase domain 2 Ribosomal_L27A PF00828.19 EFC38545.1 - 2.3e-34 118.9 0.6 3.5e-34 118.3 0.1 1.5 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Mrr_N PF14338.6 EFC38545.1 - 0.031 14.4 0.0 0.4 10.8 0.0 2.4 2 1 0 2 2 2 0 Mrr N-terminal domain Peptidase_M48_N PF16491.5 EFC38546.1 - 3.9e-30 105.1 23.4 1.9e-20 73.6 0.1 3.3 3 1 1 4 4 4 2 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 EFC38546.1 - 1.4e-29 103.3 0.0 2.3e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 DUF2268 PF10026.9 EFC38546.1 - 0.03 13.9 0.4 0.077 12.6 0.1 1.7 2 0 0 2 2 2 0 Predicted Zn-dependent protease (DUF2268) Yop-YscD_cpl PF16697.5 EFC38546.1 - 0.033 14.5 0.0 0.077 13.3 0.0 1.6 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DUF872 PF05915.12 EFC38546.1 - 0.04 14.1 0.4 0.26 11.5 0.0 2.5 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) DUF2371 PF10177.9 EFC38546.1 - 0.11 12.6 0.1 0.33 11.1 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) RRM_1 PF00076.22 EFC38547.1 - 1.5e-30 104.8 11.3 1e-07 31.7 0.2 6.5 5 1 1 6 6 6 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFC38547.1 - 6.6e-05 22.9 5.1 0.27 11.3 0.0 4.3 4 0 0 4 4 4 2 RNA binding motif tRNA-synt_1c PF00749.21 EFC38547.1 - 0.0062 15.5 1.6 0.015 14.2 0.3 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain Nup35_RRM_2 PF14605.6 EFC38547.1 - 0.014 15.4 1.3 10 6.2 0.0 4.4 4 1 0 4 4 4 0 Nup53/35/40-type RNA recognition motif SET_assoc PF11767.8 EFC38547.1 - 0.023 14.3 0.7 9.6 5.9 0.3 2.9 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated GMP_PDE_delta PF05351.11 EFC38548.1 - 3.6e-61 205.8 2.6 4.2e-61 205.6 2.6 1.0 1 0 0 1 1 1 1 GMP-PDE, delta subunit DUF4821 PF16092.5 EFC38549.1 - 2.8e-33 115.7 6.1 8.8e-33 114.1 0.2 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4821) Pyr_redox_2 PF07992.14 EFC38549.1 - 0.00096 18.5 0.0 0.18 11.0 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase SlyX PF04102.12 EFC38551.1 - 0.048 14.3 0.2 0.048 14.3 0.2 6.5 3 3 2 5 5 5 0 SlyX Spc7 PF08317.11 EFC38551.1 - 0.056 12.3 66.4 0.082 11.8 6.5 3.3 1 1 2 3 3 3 0 Spc7 kinetochore protein LPP PF04728.13 EFC38551.1 - 1.3 9.5 8.7 1.6 9.2 0.0 4.6 4 1 1 5 5 5 0 Lipoprotein leucine-zipper APG6_N PF17675.1 EFC38551.1 - 4.4 7.8 70.7 0.081 13.4 11.9 4.6 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF2937 PF11157.8 EFC38551.1 - 7.4 6.3 5.4 1.1 8.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) SRP54 PF00448.22 EFC38552.1 - 3.8e-73 245.3 0.7 5.8e-73 244.7 0.7 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFC38552.1 - 1.3e-28 99.5 3.2 1.3e-28 99.5 3.2 2.3 3 0 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 EFC38552.1 - 1.1e-13 51.1 1.5 3.4e-13 49.6 0.2 2.4 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain AAA_17 PF13207.6 EFC38552.1 - 2.6e-05 24.7 0.1 6.9e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 EFC38552.1 - 8.6e-05 22.2 0.6 0.00072 19.2 0.6 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EFC38552.1 - 0.0006 19.6 0.0 0.001 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 EFC38552.1 - 0.00072 19.6 0.0 0.0023 18.0 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EFC38552.1 - 0.0071 16.6 0.0 0.026 14.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain Fe-ADH PF00465.19 EFC38552.1 - 0.019 13.8 0.0 0.04 12.7 0.0 1.5 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase ResIII PF04851.15 EFC38552.1 - 0.027 14.5 0.1 0.06 13.4 0.1 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 EFC38552.1 - 0.045 13.9 0.0 0.089 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EFC38552.1 - 0.05 13.7 0.3 0.15 12.1 0.3 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase CobN-Mg_chel PF02514.16 EFC38552.1 - 0.055 11.2 0.1 0.082 10.6 0.1 1.2 1 0 0 1 1 1 0 CobN/Magnesium Chelatase DUF373 PF04123.13 EFC38552.1 - 0.062 12.7 1.0 0.1 12.0 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Herpes_V23 PF01802.17 EFC38552.1 - 0.18 11.2 0.7 1.3 8.3 0.7 2.2 1 1 0 1 1 1 0 Herpesvirus VP23 like capsid protein eIF3_subunit PF08597.10 EFC38553.1 - 1e-27 97.6 27.6 1e-27 97.6 27.6 2.1 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit MaoC_dehydratas PF01575.19 EFC38553.1 - 2.1e-17 62.8 0.0 6e-17 61.4 0.0 1.7 1 0 0 1 1 1 1 MaoC like domain PPR_2 PF13041.6 EFC38553.1 - 2.8e-07 30.6 1.8 9.7e-07 28.9 0.1 2.7 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.6 EFC38553.1 - 1.3e-06 28.3 0.8 0.00033 20.7 0.2 3.3 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC38553.1 - 0.00021 20.7 0.6 0.00068 19.1 0.6 1.9 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP MaoC_dehydrat_N PF13452.6 EFC38553.1 - 0.00053 20.1 0.0 0.0027 17.9 0.0 2.2 2 0 0 2 2 2 1 N-terminal half of MaoC dehydratase PPR PF01535.20 EFC38553.1 - 0.021 15.0 0.7 28 5.3 0.2 3.9 3 0 0 3 3 3 0 PPR repeat DUF768 PF05589.11 EFC38553.1 - 0.65 10.0 2.6 2.3 8.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF768) Nas2_N PF18265.1 EFC38553.1 - 4.3 7.3 7.4 0.17 11.8 0.4 2.3 2 0 0 2 2 2 0 Nas2 N_terminal domain SNF2_N PF00176.23 EFC38554.1 - 3.9e-26 91.6 1.5 7.7e-22 77.5 0.1 2.5 1 1 1 2 2 2 2 SNF2 family N-terminal domain DUF1086 PF06461.11 EFC38554.1 - 2.7e-19 69.4 0.0 8e-19 67.9 0.0 1.8 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1086) Chromo PF00385.24 EFC38554.1 - 5.3e-06 26.2 1.5 0.00023 21.0 0.0 3.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain CHDCT2 PF08074.11 EFC38554.1 - 1.3e-05 25.5 1.1 0.0001 22.6 0.1 2.9 2 0 0 2 2 2 1 CHDCT2 (NUC038) domain ResIII PF04851.15 EFC38554.1 - 0.00093 19.2 0.0 0.00093 19.2 0.0 3.8 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit Ras PF00071.22 EFC38555.1 - 3.9e-35 120.8 0.0 4.8e-35 120.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38555.1 - 3.1e-13 50.0 0.0 6.4e-13 49.0 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC38555.1 - 0.00015 21.3 0.0 0.00039 19.9 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF5388 PF17363.2 EFC38556.1 - 0.2 11.9 1.5 25 5.2 0.1 3.1 2 0 0 2 2 2 0 Family of unknown function (DUF5388) Bac_surface_Ag PF01103.23 EFC38558.1 - 2.7e-33 115.9 3.4 3.8e-33 115.3 3.4 1.2 1 0 0 1 1 1 1 Surface antigen TRAM_LAG1_CLN8 PF03798.16 EFC38560.1 - 1.4e-21 77.1 16.9 1.4e-21 77.1 16.9 2.0 1 1 1 2 2 2 1 TLC domain Pkinase PF00069.25 EFC38561.1 - 8.5e-52 176.1 0.0 9.8e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38561.1 - 8.1e-33 113.8 0.0 1e-32 113.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC38561.1 - 4.3e-08 32.3 0.0 5.8e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC38561.1 - 3.8e-05 23.2 0.0 5.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EFC38561.1 - 0.013 14.6 0.0 0.017 14.2 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EFC38561.1 - 0.016 14.1 0.2 0.021 13.8 0.2 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFC38561.1 - 0.028 13.8 0.1 0.067 12.5 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CTP_transf_3 PF02348.19 EFC38561.1 - 0.052 13.5 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 Cytidylyltransferase YrbL-PhoP_reg PF10707.9 EFC38561.1 - 0.11 12.0 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kelch_5 PF13854.6 EFC38562.1 - 1.5e-40 136.6 4.1 2e-09 37.2 0.1 6.7 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFC38562.1 - 1.2e-38 130.9 3.6 1.8e-06 27.9 0.0 7.0 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC38562.1 - 3.5e-28 96.9 2.0 0.00011 21.8 0.0 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFC38562.1 - 1.2e-27 95.6 8.6 3.2e-09 36.9 0.1 7.4 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC38562.1 - 2.5e-25 87.8 5.0 0.00023 21.3 0.0 6.4 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EFC38562.1 - 5.8e-17 60.9 8.5 0.00065 19.6 0.2 6.6 6 0 0 6 6 6 5 Kelch motif SAM_1 PF00536.30 EFC38562.1 - 1.5e-16 60.6 0.0 2.9e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC38562.1 - 1.2e-12 47.7 0.0 2.5e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF2048 PF09752.9 EFC38562.1 - 0.12 11.4 0.0 14 4.6 0.0 2.4 2 0 0 2 2 2 0 Abhydrolase domain containing 18 Occludin_ELL PF07303.13 EFC38562.1 - 0.18 12.5 0.9 3.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Occludin homology domain RCC1 PF00415.18 EFC38563.1 - 8.7e-24 83.9 5.1 6.5e-05 23.5 0.1 7.1 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC38563.1 - 1.9e-16 59.4 27.1 8.1e-05 22.3 1.6 7.5 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat Amidase PF01425.21 EFC38564.1 - 7.2e-79 265.9 0.0 2.2e-78 264.3 0.0 1.7 1 1 0 1 1 1 1 Amidase Pkinase PF00069.25 EFC38565.1 - 6e-60 202.8 0.8 2.5e-58 197.5 0.0 3.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38565.1 - 1.8e-33 115.9 0.2 9.8e-32 110.2 0.0 2.8 3 0 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC38565.1 - 2.3e-06 27.2 0.0 6.3e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC38565.1 - 0.075 13.0 0.0 2.4 8.0 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFC38565.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family XRN1_D2_D3 PF18334.1 EFC38565.1 - 0.27 11.5 0.9 2.3 8.5 0.0 2.8 3 0 0 3 3 3 0 Exoribonuclease Xrn1 D2/D3 domain Sec34 PF04136.15 EFC38565.1 - 1.1 9.1 9.4 0.094 12.6 3.2 2.4 2 0 0 2 2 2 0 Sec34-like family tRNA-synt_1d PF00750.19 EFC38568.1 - 1.6e-93 313.5 3.7 3.8e-92 308.9 3.7 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFC38568.1 - 5.2e-06 26.6 1.3 0.00029 21.0 0.1 2.6 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 EFC38568.1 - 0.0042 17.6 0.0 0.023 15.3 0.0 2.3 2 0 0 2 2 2 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1e PF01406.19 EFC38568.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Circo_capsid PF02443.15 EFC38568.1 - 0.093 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Circovirus capsid protein DUF5601 PF18151.1 EFC38568.1 - 0.1 12.9 0.2 4.5 7.7 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) FHA PF00498.26 EFC38569.1 - 1.2e-14 54.3 0.6 3e-14 53.1 0.6 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_2 PF13639.6 EFC38569.1 - 8.3e-10 38.9 13.2 1.8e-09 37.8 13.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFC38569.1 - 8.6e-10 38.3 9.5 1.5e-09 37.5 9.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC38569.1 - 8e-09 35.2 12.8 8e-09 35.2 12.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC38569.1 - 4.1e-08 32.9 13.6 1e-07 31.7 13.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC38569.1 - 6.2e-08 32.5 11.4 1.5e-07 31.3 11.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFC38569.1 - 1.4e-07 31.5 14.3 3.2e-07 30.4 14.3 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFC38569.1 - 2.9e-06 27.0 9.3 6.5e-06 25.9 9.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Yop-YscD_cpl PF16697.5 EFC38569.1 - 2.1e-05 24.8 0.0 5.7e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 EFC38569.1 - 4.3e-05 23.4 14.0 0.00014 21.8 14.0 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 EFC38569.1 - 4.6e-05 23.6 12.9 0.00026 21.2 12.9 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain U-box PF04564.15 EFC38569.1 - 0.00061 19.9 0.0 0.0034 17.5 0.0 2.1 2 0 0 2 2 2 1 U-box domain zf-RING_10 PF16685.5 EFC38569.1 - 0.0032 17.6 11.0 0.0075 16.4 11.0 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 EFC38569.1 - 0.0038 17.2 3.6 0.012 15.6 3.6 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF1640 PF07798.11 EFC38569.1 - 0.032 14.3 0.5 0.032 14.3 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) zf-RING_4 PF14570.6 EFC38569.1 - 4.5 7.1 15.2 0.038 13.8 5.9 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 EFC38569.1 - 9.9 6.4 11.3 5.1 7.3 5.1 2.8 2 1 0 2 2 2 0 Zinc-binding RING-finger PMC2NT PF08066.12 EFC38570.1 - 2.8 8.7 8.7 0.27 12.0 0.7 3.4 3 1 1 4 4 4 0 PMC2NT (NUC016) domain GTP_EFTU PF00009.27 EFC38571.1 - 5.6e-41 140.2 0.5 2.1e-40 138.4 0.2 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC38571.1 - 2.3e-22 79.4 0.3 1.3e-21 77.0 0.2 2.3 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFC38571.1 - 5.7e-06 26.4 0.2 3.7e-05 23.8 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFC38571.1 - 0.00055 20.3 2.7 0.00076 19.8 1.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu domain 2 bMG3 PF11974.8 EFC38571.1 - 0.015 15.3 0.1 0.063 13.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain GTP_EFTU_D4 PF14578.6 EFC38571.1 - 0.1 12.5 0.7 0.5 10.3 0.4 2.2 2 0 0 2 2 2 0 Elongation factor Tu domain 4 ABC2_membrane PF01061.24 EFC38572.1 - 1.2e-41 142.4 19.7 1.6e-41 142.1 19.7 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC38572.1 - 5.5e-15 56.1 0.2 2.6e-14 53.9 0.1 2.0 2 0 0 2 2 2 1 ABC transporter ABC2_membrane_3 PF12698.7 EFC38572.1 - 2.9e-07 29.9 9.6 3.9e-07 29.5 9.6 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFC38572.1 - 7.4e-05 22.7 0.1 0.0002 21.3 0.1 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_35 PF14516.6 EFC38572.1 - 0.00017 20.6 0.1 0.03 13.2 0.0 2.7 3 0 0 3 3 3 1 AAA-like domain AAA_16 PF13191.6 EFC38572.1 - 0.0011 19.4 0.1 0.003 17.9 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EFC38572.1 - 0.0094 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC38572.1 - 0.022 14.9 0.1 0.071 13.3 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC38572.1 - 0.03 14.6 0.0 0.11 12.8 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC38572.1 - 0.039 14.5 0.1 0.1 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EFC38572.1 - 0.04 13.7 0.0 0.081 12.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 EFC38572.1 - 0.076 13.1 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase BCDHK_Adom3 PF10436.9 EFC38572.1 - 0.079 12.8 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase AAA_23 PF13476.6 EFC38572.1 - 0.11 13.0 0.1 0.47 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFC38572.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 EFC38572.1 - 0.14 12.4 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFC38572.1 - 0.15 11.8 0.1 0.4 10.4 0.1 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein cobW PF02492.19 EFC38572.1 - 0.16 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EFC38572.1 - 0.16 11.6 0.3 0.77 9.4 0.1 2.2 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.6 EFC38572.1 - 0.17 11.4 0.2 0.42 10.1 0.1 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 EFC38572.1 - 0.18 11.1 0.0 0.34 10.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DRMBL PF07522.14 EFC38573.1 - 9.7e-13 48.3 1.4 2.3e-12 47.1 0.2 2.4 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 EFC38573.1 - 0.0028 17.7 3.1 0.45 10.5 1.9 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily RMMBL PF07521.12 EFC38573.1 - 0.0097 15.8 0.0 0.033 14.1 0.0 1.9 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain DNA_ligase_IV PF11411.8 EFC38575.1 - 0.042 14.0 0.1 3.4 7.8 0.0 2.7 2 0 0 2 2 2 0 DNA ligase IV Pyr_redox_2 PF07992.14 EFC38576.1 - 3.5e-43 147.9 0.1 5.8e-43 147.2 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFC38576.1 - 1.7e-26 92.6 0.0 3.1e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFC38576.1 - 1.5e-10 41.4 0.1 1.5e-10 41.4 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC38576.1 - 1.3e-06 27.9 0.1 1.3e-06 27.9 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EFC38576.1 - 0.011 15.6 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glucokinase PF02685.16 EFC38576.1 - 0.054 12.5 0.0 8.1 5.3 0.0 2.8 3 0 0 3 3 3 0 Glucokinase GIDA PF01134.22 EFC38576.1 - 0.085 11.9 0.0 2.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A MCM PF00493.23 EFC38577.1 - 2.4e-104 347.3 0.2 4.2e-104 346.5 0.2 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC38577.1 - 3.7e-36 123.8 0.4 7e-36 122.9 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFC38577.1 - 1.2e-24 86.5 0.2 3e-24 85.2 0.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFC38577.1 - 3.2e-11 43.0 0.1 6.3e-09 35.5 0.0 2.9 2 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFC38577.1 - 1.4e-07 31.6 0.0 1e-06 28.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) MCM_N PF14551.6 EFC38577.1 - 5.6e-07 30.1 3.5 1e-06 29.3 0.2 2.9 3 0 0 3 3 3 1 MCM N-terminal domain MCM2_N PF12619.8 EFC38577.1 - 7.9e-06 26.2 24.9 7.9e-06 26.2 24.9 3.6 4 1 0 4 4 3 1 Mini-chromosome maintenance protein 2 AAA_3 PF07726.11 EFC38577.1 - 1.6e-05 24.8 0.1 0.00048 20.0 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 EFC38577.1 - 0.0019 18.6 1.3 0.014 15.8 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC38577.1 - 0.002 17.9 0.1 0.017 14.9 0.1 2.2 1 1 0 1 1 1 1 Sigma-54 interaction domain Colicin-DNase PF12639.7 EFC38577.1 - 0.031 15.1 0.2 0.031 15.1 0.2 3.0 3 0 0 3 3 3 0 DNase/tRNase domain of colicin-like bacteriocin AAA_16 PF13191.6 EFC38577.1 - 0.066 13.6 1.0 0.45 10.9 0.1 2.7 3 1 0 3 3 3 0 AAA ATPase domain AAA_30 PF13604.6 EFC38577.1 - 0.13 12.0 2.0 0.17 11.6 0.2 2.1 3 0 0 3 3 3 0 AAA domain Sigma54_activ_2 PF14532.6 EFC38577.1 - 0.13 12.3 0.0 0.48 10.5 0.0 1.9 1 0 0 1 1 1 0 Sigma-54 interaction domain Sel1 PF08238.12 EFC38578.1 - 1.6e-55 184.3 18.2 6e-09 36.3 0.0 11.4 11 0 0 11 11 11 10 Sel1 repeat TPR_7 PF13176.6 EFC38578.1 - 5.9e-09 35.3 4.2 0.43 10.7 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38578.1 - 1.7e-07 30.9 13.9 0.0037 17.1 0.8 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38578.1 - 1.1e-05 25.6 11.2 0.0022 18.3 1.3 5.2 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38578.1 - 2e-05 24.2 28.4 0.00065 19.4 1.0 8.4 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38578.1 - 4.6e-05 23.2 23.2 0.0073 16.3 0.9 8.4 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38578.1 - 0.0026 18.3 7.9 22 5.9 0.3 6.3 6 1 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC38578.1 - 0.0028 17.8 1.9 0.22 11.8 0.5 3.0 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFC38578.1 - 0.0047 17.0 18.0 1.6 9.1 0.4 7.4 6 2 0 6 6 6 2 Tetratricopeptide repeat DUF5112 PF17139.4 EFC38578.1 - 0.0076 15.8 0.7 0.021 14.3 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF5112) TPR_17 PF13431.6 EFC38578.1 - 0.024 15.0 17.9 18 6.0 3.8 7.3 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC38578.1 - 0.087 12.8 0.6 1.7 8.7 0.6 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC38578.1 - 0.38 11.4 0.1 0.38 11.4 0.1 4.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC38578.1 - 5.2 7.7 7.4 2 9.0 0.2 3.7 5 0 0 5 5 4 0 Tetratricopeptide repeat TAFII55_N PF04658.13 EFC38579.1 - 1.2e-18 67.4 8.6 3.6e-18 65.8 3.8 3.6 3 1 1 4 4 4 2 TAFII55 protein conserved region Arc PF03869.14 EFC38579.1 - 0.0019 18.0 0.3 0.0044 16.8 0.3 1.5 1 0 0 1 1 1 1 Arc-like DNA binding domain RHH_1 PF01402.21 EFC38579.1 - 0.021 14.8 0.3 0.075 13.0 0.3 1.9 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family ATP_bind_3 PF01171.20 EFC38580.1 - 4.3e-31 108.1 0.0 6.2e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 PP-loop family AAA PF00004.29 EFC38581.1 - 0.13 12.6 0.2 0.13 12.6 0.2 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Cpn60_TCP1 PF00118.24 EFC38582.1 - 8.4e-145 483.1 8.2 9.5e-145 483.0 8.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF356 PF04009.12 EFC38582.1 - 0.045 14.0 0.2 0.5 10.7 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF356) DUF892 PF05974.12 EFC38582.1 - 0.11 12.5 0.8 0.75 9.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF892) RimK PF08443.11 EFC38583.1 - 1.2e-46 158.7 0.0 1.7e-46 158.2 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 EFC38583.1 - 2.3e-14 53.2 0.1 3.8e-14 52.5 0.1 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain Rimk_N PF18030.1 EFC38583.1 - 7.6e-14 51.9 0.0 1.6e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 RimK PreATP-grasp domain ATP-grasp_3 PF02655.14 EFC38583.1 - 3.3e-10 40.2 0.0 7.4e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EFC38583.1 - 2.5e-09 36.8 0.6 0.0014 17.9 0.6 3.2 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp PF02222.22 EFC38583.1 - 4.6e-06 26.3 0.1 2e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_YheCD PF14398.6 EFC38583.1 - 1.5e-05 24.4 1.2 0.022 14.0 1.2 3.2 1 1 0 1 1 1 1 YheC/D like ATP-grasp TTL PF03133.15 EFC38583.1 - 8.3e-05 21.8 2.0 0.0096 15.1 0.1 2.8 3 0 0 3 3 3 2 Tubulin-tyrosine ligase family Dala_Dala_lig_C PF07478.13 EFC38583.1 - 0.00011 21.8 0.1 0.0017 17.9 0.1 2.3 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 EFC38583.1 - 0.026 14.0 0.0 0.046 13.2 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Synapsin_C PF02750.14 EFC38583.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Synapsin, ATP binding domain DUF302 PF03625.14 EFC38584.1 - 0.17 11.8 0.0 30 4.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function DUF302 Ras PF00071.22 EFC38585.1 - 1.4e-36 125.5 0.1 1.7e-36 125.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38585.1 - 6.4e-34 116.7 0.0 9e-34 116.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC38585.1 - 9.6e-11 41.4 0.0 1.2e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC38585.1 - 4.1e-06 26.9 0.0 5.9e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC38585.1 - 3.4e-05 23.5 0.0 0.00033 20.3 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC38585.1 - 4.9e-05 22.8 0.0 6e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EFC38585.1 - 0.00023 21.0 0.0 0.013 15.3 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EFC38585.1 - 0.00057 19.4 0.0 0.00093 18.7 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFC38585.1 - 0.0025 17.7 0.1 2.2 8.1 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase Beta_elim_lyase PF01212.21 EFC38585.1 - 0.0096 15.2 0.0 0.014 14.6 0.0 1.2 1 1 0 1 1 1 1 Beta-eliminating lyase TniB PF05621.11 EFC38585.1 - 0.016 14.6 0.0 0.036 13.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 EFC38585.1 - 0.069 13.5 0.0 0.16 12.4 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain RusA PF05866.11 EFC38585.1 - 0.11 13.1 0.2 0.26 11.8 0.2 1.6 1 1 0 1 1 1 0 Endodeoxyribonuclease RusA DEAD PF00270.29 EFC38586.1 - 2.1e-20 73.2 0.0 2.7e-09 37.0 0.0 2.6 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC38586.1 - 5.7e-05 23.4 0.1 0.00035 20.9 0.1 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Oxidored_nitro PF00148.19 EFC38586.1 - 0.12 11.1 0.0 0.34 9.6 0.0 1.7 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase tRNA-synt_1e PF01406.19 EFC38587.1 - 8e-109 363.6 5.3 1.1e-108 363.2 5.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFC38587.1 - 5.7e-20 71.4 2.7 5.5e-12 45.1 0.9 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFC38587.1 - 0.0015 16.9 0.0 0.0056 15.0 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Terminase_4 PF05119.12 EFC38587.1 - 0.063 13.7 0.1 0.3 11.6 0.1 2.1 1 1 0 1 1 1 0 Phage terminase, small subunit IF-2B PF01008.17 EFC38588.1 - 1.3e-73 247.7 1.1 1.3e-73 247.7 1.1 1.8 2 1 0 2 2 2 1 Initiation factor 2 subunit family CdhD PF03599.16 EFC38588.1 - 0.0042 15.9 0.1 0.008 14.9 0.1 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit DUF3759 PF12585.8 EFC38588.1 - 0.36 10.9 7.0 0.79 9.8 6.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3759) FAM76 PF16046.5 EFC38588.1 - 0.88 8.9 18.4 1.5 8.1 18.4 1.3 1 0 0 1 1 1 0 FAM76 protein Ax_dynein_light PF10211.9 EFC38590.1 - 0.0002 21.4 14.0 0.0002 21.4 14.0 3.2 3 0 0 3 3 3 1 Axonemal dynein light chain Tubulin-binding PF00418.19 EFC38590.1 - 0.49 10.5 2.6 1 9.4 0.7 2.6 2 0 0 2 2 2 0 Tau and MAP protein, tubulin-binding repeat DUF4407 PF14362.6 EFC38590.1 - 1.3 8.4 6.2 3 7.1 6.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 EFC38590.1 - 6.8 7.4 12.8 0.37 11.5 4.1 3.3 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) IATP PF04568.12 EFC38591.1 - 0.098 13.1 3.3 1 9.8 0.1 3.3 3 0 0 3 3 3 0 Mitochondrial ATPase inhibitor, IATP Prominin PF05478.11 EFC38591.1 - 3.8 5.3 8.7 0.15 10.0 1.6 2.0 2 0 0 2 2 2 0 Prominin GCD14 PF08704.10 EFC38593.1 - 3.2e-77 259.5 2.1 7.3e-47 160.1 0.1 3.2 2 1 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EFC38593.1 - 3.4e-06 27.0 0.0 5.3e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFC38593.1 - 7.5e-06 25.8 0.0 1.7e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFC38593.1 - 0.0087 15.5 0.3 0.031 13.7 0.0 2.1 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_25 PF13649.6 EFC38593.1 - 0.017 15.8 0.0 0.072 13.8 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain GCD14_N PF14801.6 EFC38593.1 - 0.024 14.5 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term Methyltr_RsmB-F PF01189.17 EFC38593.1 - 0.11 12.2 0.0 3.3 7.3 0.0 2.6 3 0 0 3 3 3 0 16S rRNA methyltransferase RsmB/F SNARE PF05739.19 EFC38594.1 - 0.00014 21.8 0.8 0.00014 21.8 0.8 3.3 3 0 0 3 3 3 1 SNARE domain Latrophilin PF02354.16 EFC38594.1 - 0.037 13.1 2.7 0.053 12.6 2.7 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region Synaptonemal_3 PF15191.6 EFC38594.1 - 0.039 13.7 5.6 0.76 9.6 0.0 3.7 2 1 0 3 3 3 0 Synaptonemal complex central element protein 3 MscS_porin PF12795.7 EFC38594.1 - 0.77 9.3 21.2 0.22 11.0 3.2 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain TMPIT PF07851.13 EFC38594.1 - 0.97 8.6 19.1 0.11 11.7 1.7 2.4 2 0 0 2 2 2 0 TMPIT-like protein DUF3149 PF11346.8 EFC38594.1 - 1.3 8.7 4.0 3.1 7.5 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Prominin PF05478.11 EFC38594.1 - 1.7 6.5 21.8 0.023 12.7 3.5 2.1 1 1 1 2 2 2 0 Prominin PDDEXK_6 PF04720.12 EFC38594.1 - 6.7 6.6 11.9 15 5.4 0.1 2.3 2 0 0 2 2 2 0 PDDEXK-like family of unknown function UME PF08064.13 EFC38595.1 - 0.0069 16.3 0.9 1.4 8.9 0.2 3.3 3 1 0 3 3 3 2 UME (NUC010) domain Herpes_UL69 PF05459.12 EFC38596.1 - 0.038 13.3 2.1 0.5 9.7 0.1 2.6 1 1 1 2 2 2 0 Herpesvirus transcriptional regulator family hSH3 PF14603.6 EFC38596.1 - 0.054 13.9 0.1 0.15 12.5 0.1 1.8 1 0 0 1 1 1 0 Helically-extended SH3 domain DEAD PF00270.29 EFC38597.1 - 1.4e-40 138.9 0.7 6e-39 133.6 0.0 2.9 2 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC38597.1 - 5.7e-20 71.7 0.5 2e-19 70.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFC38597.1 - 2.2e-12 47.0 0.1 4.8e-12 45.9 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFC38597.1 - 0.0054 16.7 0.0 0.0054 16.7 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFC38597.1 - 0.032 13.6 0.1 0.032 13.6 0.1 3.2 2 1 0 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit DUF4116 PF13475.6 EFC38597.1 - 0.089 12.5 2.9 6.2 6.6 0.0 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF4116) GvpG PF05120.12 EFC38597.1 - 1.6 8.8 5.3 2.3 8.3 3.4 2.4 1 1 0 1 1 1 0 Gas vesicle protein G Pox_H7 PF04787.12 EFC38597.1 - 3.9 8.0 10.5 1.3 9.5 0.4 2.8 1 1 0 2 2 2 0 Late protein H7 SR-25 PF10500.9 EFC38598.1 - 0.26 10.9 22.8 0.6 9.7 11.8 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4337 PF14235.6 EFC38598.1 - 1.9 8.6 5.7 0.23 11.5 1.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Cullin PF00888.22 EFC38599.1 - 3.4e-89 300.1 19.8 3.4e-89 300.1 19.8 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EFC38599.1 - 1.4e-22 79.4 1.9 1.4e-22 79.4 1.9 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain YmgB PF10798.8 EFC38599.1 - 0.064 13.1 1.1 0.39 10.6 0.3 2.5 2 0 0 2 2 2 0 Biofilm development protein YmgB/AriR Spo0A_C PF08769.11 EFC38599.1 - 0.11 12.6 3.4 14 5.9 0.0 3.8 4 1 0 5 5 5 0 Sporulation initiation factor Spo0A C terminal KH_6 PF15985.5 EFC38600.1 - 2e-15 56.9 0.0 3.3e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 EFC38600.1 - 0.0021 18.0 0.4 0.0053 16.7 0.0 1.9 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain ECR1_N PF14382.6 EFC38600.1 - 0.11 12.3 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 Exosome complex exonuclease RRP4 N-terminal region Actin PF00022.19 EFC38601.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin SR-25 PF10500.9 EFC38602.1 - 0.12 12.0 24.1 0.016 14.8 12.0 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein G-alpha PF00503.20 EFC38603.1 - 1.4e-96 323.8 11.5 1.7e-96 323.5 11.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC38603.1 - 9.6e-12 44.7 1.0 1.4e-08 34.4 0.2 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC38603.1 - 2.4e-05 23.8 5.4 0.0011 18.3 0.2 2.8 1 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 EFC38603.1 - 0.0029 17.3 0.1 0.011 15.4 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFC38603.1 - 0.015 15.4 1.2 5.1 7.2 0.0 3.1 3 1 0 3 3 3 0 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC38603.1 - 0.041 14.2 0.1 0.12 12.7 0.1 1.8 1 0 0 1 1 1 0 AAA domain Ribosomal_S8e PF01201.22 EFC38605.1 - 9.3e-47 158.6 0.9 1.4e-46 158.0 0.9 1.3 1 1 0 1 1 1 1 Ribosomal protein S8e Myb_DNA-binding PF00249.31 EFC38606.1 - 4.8e-24 84.3 5.7 1.7e-13 50.5 1.3 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC38606.1 - 2.9e-20 72.3 9.1 9.9e-14 51.3 3.8 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain PhaP_Bmeg PF09602.10 EFC38606.1 - 0.0025 17.8 0.4 0.0054 16.7 0.4 1.6 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF722 PF05263.11 EFC38606.1 - 0.15 12.3 0.2 0.15 12.3 0.2 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF722) CBS PF00571.28 EFC38607.1 - 1e-31 109.1 2.3 2.2e-09 37.6 0.1 4.5 4 0 0 4 4 4 4 CBS domain Imm5 PF14423.6 EFC38607.1 - 0.11 12.8 1.2 6.5 6.9 0.1 2.4 2 0 0 2 2 2 0 Immunity protein Imm5 Rft-1 PF04506.13 EFC38608.1 - 2.4e-104 349.9 44.9 3e-104 349.6 44.9 1.0 1 0 0 1 1 1 1 Rft protein tRNA-synt_His PF13393.6 EFC38609.1 - 2.5e-41 142.0 0.0 5.5e-41 140.8 0.0 1.5 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 EFC38609.1 - 3.3e-08 33.7 0.0 8.7e-08 32.3 0.0 1.6 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFC38609.1 - 7.1e-06 26.1 0.2 2.2e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2d PF01409.20 EFC38609.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) EF-hand_11 PF08976.11 EFC38610.1 - 0.0018 19.1 0.1 3.8 8.4 0.0 2.5 1 1 1 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC38610.1 - 0.0019 17.6 0.4 0.036 13.6 0.3 2.8 2 0 0 2 2 2 1 EF hand DUF5582 PF17819.1 EFC38610.1 - 0.0064 16.9 0.3 0.017 15.6 0.3 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5582) EF-hand_8 PF13833.6 EFC38610.1 - 0.0086 15.9 0.4 0.063 13.1 0.0 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 EFC38610.1 - 0.012 16.1 0.4 0.32 11.5 0.1 2.7 1 1 1 2 2 2 0 EF-hand domain pair DUF5586 PF17824.1 EFC38610.1 - 0.019 14.1 0.7 0.029 13.5 0.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5586) EF-hand_6 PF13405.6 EFC38610.1 - 0.071 13.1 0.5 0.46 10.5 0.1 2.6 3 0 0 3 3 3 0 EF-hand domain Macro PF01661.21 EFC38611.1 - 7.9e-19 67.8 0.0 4.7e-18 65.4 0.0 2.0 1 1 0 1 1 1 1 Macro domain FRB_dom PF08771.11 EFC38611.1 - 0.061 13.7 0.2 0.1 13.0 0.2 1.4 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain AAA PF00004.29 EFC38612.1 - 3.2e-13 50.3 0.2 1.7e-05 25.2 0.0 2.8 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC38612.1 - 7e-11 42.8 0.5 0.0003 21.2 0.0 3.0 2 1 1 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 EFC38612.1 - 7.8e-07 29.7 1.2 0.011 16.3 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.6 EFC38612.1 - 7.9e-07 29.4 2.7 0.058 13.7 0.1 3.5 2 1 1 3 3 3 2 AAA domain DUF815 PF05673.13 EFC38612.1 - 2e-05 23.9 0.2 0.0043 16.2 0.0 2.8 4 0 0 4 4 3 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 EFC38612.1 - 2.5e-05 24.3 1.2 0.078 13.0 0.1 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 EFC38612.1 - 5.1e-05 23.8 0.4 0.21 12.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter RNA_helicase PF00910.22 EFC38612.1 - 5.7e-05 23.4 0.9 0.22 11.9 0.1 3.3 3 0 0 3 3 2 2 RNA helicase IstB_IS21 PF01695.17 EFC38612.1 - 0.00015 21.6 0.7 1 9.1 0.1 3.2 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 EFC38612.1 - 0.00017 21.2 0.2 0.57 9.7 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region NACHT PF05729.12 EFC38612.1 - 0.00023 21.1 2.4 0.24 11.3 0.2 3.3 3 0 0 3 3 3 1 NACHT domain AAA_33 PF13671.6 EFC38612.1 - 0.00029 21.0 0.3 0.24 11.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EFC38612.1 - 0.00034 20.6 0.0 0.41 10.6 0.0 3.0 2 1 1 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 EFC38612.1 - 0.0007 19.4 0.4 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 EFC38612.1 - 0.0017 18.1 0.1 0.99 9.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Sigma54_activat PF00158.26 EFC38612.1 - 0.0021 17.8 0.1 4 7.1 0.0 3.1 2 1 1 3 3 3 1 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 EFC38612.1 - 0.0022 18.1 0.0 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 EFC38612.1 - 0.0023 17.2 0.1 0.012 14.9 0.0 2.1 2 0 0 2 2 2 1 Zeta toxin RsgA_GTPase PF03193.16 EFC38612.1 - 0.0034 17.3 0.7 0.92 9.4 0.3 2.5 2 0 0 2 2 2 1 RsgA GTPase AFG1_ATPase PF03969.16 EFC38612.1 - 0.0034 16.3 0.2 4.5 6.1 0.0 3.1 2 1 0 3 3 3 1 AFG1-like ATPase AAA_14 PF13173.6 EFC38612.1 - 0.0085 16.1 2.6 0.95 9.5 0.0 2.9 3 0 0 3 3 2 1 AAA domain APS_kinase PF01583.20 EFC38612.1 - 0.012 15.5 0.1 0.074 12.9 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase SRP54 PF00448.22 EFC38612.1 - 0.013 15.1 0.2 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_30 PF13604.6 EFC38612.1 - 0.014 15.2 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFC38612.1 - 0.014 15.3 1.0 7.4 6.5 0.4 2.9 2 1 1 3 3 3 0 Rad17 P-loop domain RuvB_N PF05496.12 EFC38612.1 - 0.02 14.6 0.0 7.8 6.2 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EFC38612.1 - 0.025 14.8 0.7 3 8.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EFC38612.1 - 0.033 14.1 0.8 8.5 6.3 0.0 2.8 3 0 0 3 3 3 0 NTPase AAA_19 PF13245.6 EFC38612.1 - 0.043 14.2 0.3 3.9 7.8 0.0 3.1 2 1 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EFC38612.1 - 0.048 12.8 0.7 4.9 6.3 0.1 2.7 2 1 1 3 3 3 0 NB-ARC domain AAA_25 PF13481.6 EFC38612.1 - 0.061 12.9 0.6 8.7 5.9 0.2 2.3 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 EFC38612.1 - 0.15 11.5 0.0 12 5.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein Roc PF08477.13 EFC38612.1 - 0.19 11.9 1.0 11 6.3 0.1 2.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Cytidylate_kin PF02224.18 EFC38612.1 - 0.25 11.1 0.2 16 5.1 0.0 3.0 3 0 0 3 3 3 0 Cytidylate kinase cobW PF02492.19 EFC38612.1 - 0.34 10.5 2.1 47 3.5 0.2 3.3 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Mg_chelatase PF01078.21 EFC38612.1 - 0.77 9.1 1.8 2.4 7.5 0.4 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 EFC38612.1 - 1.4 9.4 8.4 4.5 7.7 0.1 3.6 2 1 1 3 3 3 0 AAA domain LCAT PF02450.15 EFC38613.1 - 0.00072 18.8 0.0 0.0025 17.0 0.0 1.9 3 0 0 3 3 3 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 EFC38613.1 - 0.00073 19.1 0.0 0.063 12.8 0.0 2.3 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 EFC38613.1 - 0.097 11.9 0.0 0.39 10.0 0.0 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_8 PF06259.12 EFC38613.1 - 0.15 11.7 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase FOP_dimer PF09398.10 EFC38614.1 - 4.3e-13 49.3 1.0 9.9e-13 48.2 0.1 2.0 2 0 0 2 2 2 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 EFC38614.1 - 1.2e-06 27.4 0.1 2e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 LisH DUF3349 PF11829.8 EFC38614.1 - 0.043 14.6 1.4 0.95 10.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) EnY2 PF10163.9 EFC38614.1 - 0.11 12.8 1.4 2.1 8.7 0.3 2.4 2 0 0 2 2 2 0 Transcription factor e(y)2 Muted PF14942.6 EFC38614.1 - 0.6 10.5 10.2 2.2 8.6 3.1 3.1 2 2 0 2 2 2 0 Organelle biogenesis, Muted-like protein Hexapep PF00132.24 EFC38615.1 - 7.3e-13 47.7 13.4 5.5e-09 35.4 4.5 2.7 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFC38615.1 - 0.00013 21.6 5.9 0.00013 21.6 5.9 3.7 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase SATase_N PF06426.14 EFC38615.1 - 0.0044 17.4 0.0 0.014 15.8 0.0 1.8 2 0 0 2 2 2 1 Serine acetyltransferase, N-terminal EF-hand_1 PF00036.32 EFC38616.1 - 1.6e-15 55.4 7.4 0.00043 19.6 0.0 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC38616.1 - 3.8e-15 54.5 4.2 0.00011 21.9 0.3 3.8 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 EFC38616.1 - 3e-11 43.6 6.7 8.9e-09 35.7 1.4 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC38616.1 - 2.3e-09 36.3 4.9 0.031 13.8 0.4 3.7 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 EFC38616.1 - 5.6e-06 26.2 4.2 0.23 11.4 0.1 3.5 2 1 2 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_8 PF13833.6 EFC38616.1 - 0.00019 21.2 12.6 0.25 11.2 0.4 3.8 3 1 1 4 4 4 3 EF-hand domain pair Dockerin_1 PF00404.18 EFC38616.1 - 0.091 13.0 0.1 11 6.3 0.0 2.9 3 0 0 3 3 3 0 Dockerin type I domain TMEM214 PF10151.9 EFC38616.1 - 0.58 8.5 1.8 0.46 8.9 0.1 1.6 2 0 0 2 2 2 0 TMEM214, C-terminal, caspase 4 activator MORN PF02493.20 EFC38617.1 - 9e-39 129.1 51.5 6.2e-07 28.9 0.4 10.3 9 1 1 10 10 10 10 MORN repeat DNA_ligase_A_M PF01068.21 EFC38618.1 - 3.4e-63 213.0 0.3 3.4e-63 213.0 0.3 2.5 2 1 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFC38618.1 - 1.5e-38 132.8 0.5 3.6e-38 131.6 0.5 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 EFC38618.1 - 3.4e-24 85.3 0.0 1.2e-23 83.5 0.0 2.0 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EFC38618.1 - 9.2e-06 26.1 0.1 2e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 RNA ligase IU_nuc_hydro PF01156.19 EFC38618.1 - 0.043 13.4 0.2 0.093 12.3 0.0 1.7 2 0 0 2 2 2 0 Inosine-uridine preferring nucleoside hydrolase DNA_ligase_OB_2 PF14743.6 EFC38618.1 - 0.09 12.8 0.4 13 5.9 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain Presenilin PF01080.17 EFC38618.1 - 0.1 11.3 3.3 0.15 10.8 3.3 1.2 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 EFC38618.1 - 0.23 10.9 7.8 0.52 9.8 7.8 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 DUF5401 PF17380.2 EFC38618.1 - 1.7 6.6 17.8 2.5 6.1 17.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) BUD22 PF09073.10 EFC38618.1 - 2.3 7.5 21.7 4 6.7 21.7 1.3 1 0 0 1 1 1 0 BUD22 rRNA_proc-arch PF13234.6 EFC38619.1 - 1.3e-52 179.4 8.8 1.7e-52 179.1 7.1 2.1 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 EFC38619.1 - 1.5e-48 164.6 0.7 4.6e-48 163.0 0.7 1.9 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EFC38619.1 - 6.8e-19 68.3 0.0 2.2e-18 66.7 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC38619.1 - 1.1e-07 32.1 0.0 1.7e-06 28.3 0.0 2.7 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC38619.1 - 7.4e-05 22.8 0.0 0.00025 21.1 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFC38619.1 - 0.025 14.8 0.0 0.11 12.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFC38619.1 - 0.033 14.1 1.3 0.3 11.0 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 EFC38619.1 - 0.13 11.3 0.6 0.44 9.6 0.0 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein Cnd2 PF05786.14 EFC38620.1 - 8.4e-97 325.7 26.3 1.6e-96 324.8 24.5 2.0 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 EFC38620.1 - 0.0003 21.0 0.0 0.0018 18.4 0.0 2.4 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal CTU2 PF10288.9 EFC38620.1 - 0.077 13.2 0.1 0.077 13.2 0.1 4.0 5 0 0 5 5 5 0 Cytoplasmic tRNA 2-thiolation protein 2 ORF6C PF10552.9 EFC38621.1 - 0.036 14.1 0.2 0.06 13.4 0.2 1.2 1 0 0 1 1 1 0 ORF6C domain RRN3 PF05327.11 EFC38622.1 - 1.6e-74 251.5 13.7 1.6e-74 251.5 13.7 2.3 2 1 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 AIP3 PF03915.13 EFC38622.1 - 9.2 5.2 9.7 1.3 8.1 0.8 2.2 2 0 0 2 2 2 0 Actin interacting protein 3 PI31_Prot_N PF11566.8 EFC38623.1 - 5.1e-13 49.2 0.2 3.6e-12 46.4 0.2 2.2 1 1 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 EFC38623.1 - 1.6e-08 35.6 12.1 1.6e-08 35.6 12.1 2.7 3 0 0 3 3 3 1 PI31 proteasome regulator AAA_31 PF13614.6 EFC38623.1 - 0.08 12.8 1.5 0.17 11.8 1.5 1.4 1 0 0 1 1 1 0 AAA domain GPS PF01825.21 EFC38624.1 - 3.5e-09 37.0 2.6 8e-09 35.9 2.6 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif RhoGAP PF00620.27 EFC38625.1 - 1.4e-33 115.9 1.7 2.6e-33 115.0 1.7 1.4 1 0 0 1 1 1 1 RhoGAP domain MORN PF02493.20 EFC38625.1 - 1.3e-28 97.2 41.3 1.2e-06 28.1 1.3 8.5 8 0 0 8 8 8 8 MORN repeat MMU163 PF17119.5 EFC38625.1 - 0.28 10.3 2.6 0.73 8.9 2.6 1.7 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis LVIVD PF08309.11 EFC38625.1 - 0.57 9.6 2.5 0.75 9.2 0.3 2.1 2 0 0 2 2 2 0 LVIVD repeat Folliculin PF11704.8 EFC38625.1 - 1.7 8.5 6.0 0.65 9.9 1.5 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF3048_C PF17479.2 EFC38625.1 - 2 8.8 6.4 51 4.3 0.1 3.8 1 1 2 3 3 3 0 Protein of unknown function (DUF3048) C-terminal domain WD40 PF00400.32 EFC38627.1 - 6.1e-17 61.7 3.7 0.11 13.4 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC38627.1 - 1.2e-07 31.9 0.4 5.3 7.4 0.0 5.1 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFC38627.1 - 0.00015 21.7 2.2 0.26 11.3 0.1 4.6 3 2 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Hairpins PF04877.12 EFC38627.1 - 0.0028 17.4 0.2 0.0046 16.6 0.2 1.3 1 0 0 1 1 1 1 HrpZ PQQ PF01011.21 EFC38627.1 - 0.037 14.0 0.3 35 4.6 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat LRR_4 PF12799.7 EFC38628.1 - 1.5e-14 53.9 59.9 9e-05 22.8 2.2 7.8 7 1 1 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38628.1 - 2.9e-10 39.8 45.6 3.2e-05 23.6 8.6 5.8 4 2 2 6 6 6 5 Leucine rich repeat IQ PF00612.27 EFC38628.1 - 9.3e-10 37.4 9.9 0.00055 19.5 0.1 3.6 3 0 0 3 3 3 2 IQ calmodulin-binding motif LRR_9 PF14580.6 EFC38628.1 - 4.8e-08 32.7 24.2 9.8e-05 21.9 4.6 4.5 1 1 2 3 3 3 3 Leucine-rich repeat Adeno_E3_CR2 PF02439.15 EFC38628.1 - 0.19 11.5 1.4 0.38 10.5 1.4 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Arch_flagellin PF01917.16 EFC38628.1 - 0.77 9.9 6.1 2.1 8.5 6.1 1.7 1 0 0 1 1 1 0 Archaebacterial flagellin SKG6 PF08693.10 EFC38628.1 - 1.1 8.7 5.5 2.2 7.8 5.5 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RhoGEF PF00621.20 EFC38629.1 - 7.2e-20 72.0 4.5 7.2e-20 72.0 4.5 2.2 2 0 0 2 2 2 1 RhoGEF domain LRR_8 PF13855.6 EFC38629.1 - 1.9e-19 69.2 19.9 6e-10 38.7 1.7 3.7 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC38629.1 - 4.5e-10 39.6 19.2 0.00022 21.5 7.0 4.0 3 0 0 3 3 3 3 Leucine Rich repeats (2 copies) PH PF00169.29 EFC38629.1 - 0.065 13.7 3.2 1.4 9.4 0.1 3.3 3 0 0 3 3 3 0 PH domain LRR_1 PF00560.33 EFC38629.1 - 0.26 12.0 18.9 2 9.3 0.2 6.5 6 1 1 7 7 7 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC38629.1 - 0.3 11.2 11.9 4.7 7.5 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeat OTU PF02338.19 EFC38630.1 - 6.4e-11 42.8 0.4 6.4e-11 42.8 0.4 3.6 3 1 0 3 3 3 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFC38630.1 - 1.5e-06 27.9 8.5 9e-05 22.0 0.1 3.2 1 1 1 3 3 3 2 Peptidase C65 Otubain Sporozoite_P67 PF05642.11 EFC38630.1 - 0.94 7.5 9.8 1.3 7.0 9.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FUSC-like PF12805.7 EFC38630.1 - 2.9 6.9 8.0 0.3 10.1 2.5 2.0 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS SMC_N PF02463.19 EFC38631.1 - 2.8e-62 210.0 29.6 3e-61 206.7 29.6 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFC38631.1 - 1.1e-18 67.6 2.0 1.4e-18 67.3 0.4 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EFC38631.1 - 2.1e-16 60.6 15.2 2.1e-16 60.6 15.2 3.2 1 1 2 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 EFC38631.1 - 3.8e-15 56.5 6.2 4.3e-08 33.3 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFC38631.1 - 1.1e-11 45.6 28.8 1.1e-11 45.6 28.8 5.5 2 2 2 4 4 4 1 AAA domain AAA_29 PF13555.6 EFC38631.1 - 2.7e-05 23.8 0.1 7.8e-05 22.3 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EFC38631.1 - 0.0059 17.1 0.1 0.14 12.7 0.0 5.5 3 1 1 4 4 4 2 ABC transporter MHB PF16525.5 EFC38631.1 - 0.13 12.5 0.3 0.7 10.2 0.1 2.4 2 0 0 2 2 2 0 Haemophore, haem-binding SNCAIP_SNCA_bd PF16700.5 EFC38631.1 - 0.93 9.3 5.9 18 5.1 1.6 3.1 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain PhzC-PhzF PF02567.16 EFC38632.1 - 6.8e-52 176.7 0.0 1.3e-50 172.4 0.0 2.0 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein UBA_3 PF09288.10 EFC38632.1 - 0.078 12.8 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain TPR_12 PF13424.6 EFC38633.1 - 4.4e-06 26.9 1.5 49 4.3 0.0 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38633.1 - 0.00018 21.3 0.3 1.6 8.7 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38633.1 - 0.00022 20.9 3.6 2.7 7.9 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38633.1 - 0.00022 21.1 3.5 1.9 8.8 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat IQ PF00612.27 EFC38633.1 - 0.00082 19.0 0.6 0.002 17.7 0.6 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif TPR_8 PF13181.6 EFC38633.1 - 0.0041 17.2 5.8 25 5.4 0.1 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat DASH_Dam1 PF08653.10 EFC38633.1 - 1.1 9.2 4.3 27 4.7 0.1 3.9 4 1 0 4 4 4 0 DASH complex subunit Dam1 PseudoU_synth_2 PF00849.22 EFC38634.1 - 1.9e-24 86.6 0.0 2.8e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Zn_ribbon_17 PF17120.5 EFC38635.1 - 2.1e-10 40.0 11.7 5.1e-10 38.8 11.7 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 EFC38635.1 - 3e-08 34.2 29.3 0.00076 20.2 0.2 7.1 8 0 0 8 8 8 3 WD domain, G-beta repeat zinc_ribbon_16 PF17034.5 EFC38635.1 - 3e-08 33.9 8.0 1.8e-07 31.4 8.0 2.4 1 0 0 1 1 1 1 Zinc-ribbon like family RWD PF05773.22 EFC38635.1 - 0.0048 17.2 0.4 0.0048 17.2 0.4 2.6 2 1 0 2 2 2 1 RWD domain ZirS_C PF16583.5 EFC38635.1 - 0.015 14.9 0.2 0.074 12.6 0.2 2.2 1 0 0 1 1 1 0 Zinc-regulated secreted antivirulence protein C-terminal domain zf-RING_2 PF13639.6 EFC38635.1 - 0.047 14.0 7.4 0.17 12.3 7.4 2.0 1 0 0 1 1 1 0 Ring finger domain zinc_ribbon_15 PF17032.5 EFC38635.1 - 0.052 14.3 3.1 0.22 12.3 3.1 2.2 1 0 0 1 1 1 0 zinc-ribbon family Zn_clus PF00172.18 EFC38636.1 - 2.5e-07 30.7 14.7 3.9e-07 30.1 14.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 EFC38636.1 - 0.3 11.1 1.6 0.59 10.2 1.6 1.5 1 0 0 1 1 1 0 AT hook motif APC_N_CC PF16689.5 EFC38637.1 - 0.0022 18.0 13.8 0.0078 16.3 6.8 5.8 4 2 1 5 5 5 2 Coiled-coil N-terminus of APC, dimerisation domain CENP-K PF11802.8 EFC38637.1 - 0.0025 17.4 20.5 0.0025 17.4 20.5 4.1 1 1 3 4 4 4 2 Centromere-associated protein K ATG16 PF08614.11 EFC38637.1 - 0.019 15.2 12.1 0.019 15.2 12.1 5.6 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 EFC38637.1 - 0.083 12.9 89.9 1.2 9.1 17.1 4.9 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lipoprotein_19 PF13617.6 EFC38637.1 - 3.9 7.3 6.4 3.8 7.4 0.3 3.6 3 0 0 3 3 3 0 YnbE-like lipoprotein MbeD_MobD PF04899.12 EFC38637.1 - 5.1 7.3 23.1 0.67 10.1 0.8 5.3 4 2 1 5 5 5 0 MbeD/MobD like RPN1_RPN2_N PF17781.1 EFC38639.1 - 0.016 14.7 0.6 0.028 13.9 0.6 1.3 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain Ribosomal_L22 PF00237.19 EFC38639.1 - 0.099 12.9 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e DNA_primase_S PF01896.19 EFC38640.1 - 1.9e-40 138.8 0.4 3.6e-40 137.9 0.4 1.5 1 0 0 1 1 1 1 DNA primase small subunit DUF1810 PF08837.11 EFC38640.1 - 0.04 13.7 0.1 10 5.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1810) VWD PF00094.25 EFC38641.1 - 3.8e-12 46.8 3.5 6e-05 23.4 0.0 3.5 3 0 0 3 3 3 2 von Willebrand factor type D domain DUF3553 PF12073.8 EFC38641.1 - 0.042 13.6 0.3 15 5.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3553) DUF3343 PF11823.8 EFC38641.1 - 0.5 9.9 2.1 40 3.8 0.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) Ferritin PF00210.24 EFC38641.1 - 0.61 10.0 8.5 0.4 10.6 0.4 3.9 3 1 0 3 3 3 0 Ferritin-like domain Ribonuc_red_sm PF00268.21 EFC38642.1 - 4.8e-121 403.5 1.4 6e-121 403.2 1.4 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Haem_oxygenas_2 PF14518.6 EFC38642.1 - 0.069 12.9 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Iron-containing redox enzyme COX14 PF14880.6 EFC38643.1 - 0.036 13.9 0.1 0.055 13.3 0.1 1.4 1 1 0 1 1 1 0 Cytochrome oxidase c assembly DUF2418 PF10332.9 EFC38643.1 - 0.055 14.0 0.0 0.076 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) Mac PF12464.8 EFC38643.1 - 0.11 12.8 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Maltose acetyltransferase WD40 PF00400.32 EFC38644.1 - 2.1e-23 82.2 20.7 2.6e-05 24.9 0.2 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat NLE PF08154.12 EFC38644.1 - 1.6e-16 60.6 0.2 3.8e-16 59.3 0.2 1.7 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 EFC38644.1 - 6.2e-09 36.0 2.5 0.03 14.6 0.0 4.4 4 0 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC38644.1 - 6.4e-05 21.8 6.2 0.039 12.6 0.4 4.0 2 1 1 4 4 4 3 Nucleoporin Nup120/160 E1_dh PF00676.20 EFC38645.1 - 9.2e-97 323.6 0.0 1.2e-96 323.2 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EFC38645.1 - 0.0083 15.4 0.0 0.018 14.3 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase YpM PF09144.10 EFC38645.1 - 0.039 14.1 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Yersinia pseudo-tuberculosis mitogen DUF3461 PF11944.8 EFC38646.1 - 1.4 9.1 7.6 3.6 7.7 0.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3461) Kinesin PF00225.23 EFC38647.1 - 5.2e-43 147.2 16.2 1e-30 106.8 4.4 2.9 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 EFC38647.1 - 6.3e-13 48.9 7.5 6.3e-13 48.9 7.5 3.3 2 1 0 2 2 2 1 Microtubule binding T2SSE PF00437.20 EFC38647.1 - 0.00012 21.3 0.1 0.0002 20.5 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.22 EFC38647.1 - 0.0012 19.2 0.6 0.0074 16.7 0.1 2.6 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 EFC38647.1 - 0.0077 16.6 0.0 0.18 12.2 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EFC38647.1 - 0.0091 16.4 0.1 0.17 12.3 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 EFC38647.1 - 0.027 14.5 1.4 0.083 12.9 0.1 2.5 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit CSN8_PSD8_EIF3K PF10075.9 EFC38648.1 - 3.4e-29 101.7 0.1 4.1e-29 101.4 0.1 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EFC38648.1 - 0.0015 18.0 0.0 0.0016 17.9 0.0 1.1 1 0 0 1 1 1 1 SAC3/GANP family PCI PF01399.27 EFC38648.1 - 0.0082 16.6 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 PCI domain Pkinase PF00069.25 EFC38649.1 - 1.1e-31 110.2 0.0 1.4e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38649.1 - 2.9e-15 56.3 0.0 3.4e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC38649.1 - 8.8e-08 31.3 0.0 1.1e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC38649.1 - 0.0013 18.7 0.0 0.01 15.8 0.0 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC38649.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF410 PF04190.13 EFC38650.1 - 3.7e-56 190.8 3.9 4.7e-56 190.4 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF5076 PF16826.5 EFC38650.1 - 0.014 15.3 0.3 0.058 13.3 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5076) Skp1_POZ PF03931.15 EFC38650.1 - 0.031 14.4 0.5 0.069 13.3 0.5 1.6 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain FAM221 PF14753.6 EFC38651.1 - 0.029 14.0 0.0 0.041 13.4 0.0 1.5 1 1 0 1 1 1 0 Protein FAM221A/B JIP_LZII PF16471.5 EFC38652.1 - 0.017 15.3 1.4 0.017 15.3 1.4 3.1 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II ZapB PF06005.12 EFC38652.1 - 0.048 14.1 4.2 0.048 14.1 4.2 3.7 2 1 1 3 3 3 0 Cell division protein ZapB Ribosomal_L29 PF00831.23 EFC38652.1 - 2.9 7.9 14.1 4.4 7.4 1.0 3.2 2 1 1 3 3 3 0 Ribosomal L29 protein CobA_CobO_BtuR PF02572.15 EFC38652.1 - 5.2 7.3 7.3 23 5.2 0.4 2.5 1 1 1 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Laminin_G_3 PF13385.6 EFC38653.1 - 1.1e-20 74.3 1.3 1.5e-20 73.9 1.3 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 EFC38653.1 - 5.8e-07 30.1 0.0 1e-06 29.3 0.0 1.4 1 0 0 1 1 1 1 Laminin G domain Laminin_G_1 PF00054.23 EFC38653.1 - 0.038 14.2 0.0 0.071 13.3 0.0 1.4 1 0 0 1 1 1 0 Laminin G domain DUF5348 PF17295.2 EFC38654.1 - 0.11 12.4 0.5 0.99 9.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) PET117 PF15786.5 EFC38654.1 - 2.2 8.6 5.8 5.2 7.4 5.8 1.6 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial C2 PF00168.30 EFC38656.1 - 5.5e-17 61.9 0.3 1.1e-16 61.0 0.3 1.5 1 0 0 1 1 1 1 C2 domain Zn_clus PF00172.18 EFC38657.1 - 0.0025 17.9 2.3 0.0052 16.9 2.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CRAL_TRIO PF00650.20 EFC38658.1 - 4.4e-28 98.0 0.0 1.1e-27 96.7 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC38658.1 - 6.1e-07 29.5 0.8 6.1e-07 29.5 0.8 2.1 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 EFC38658.1 - 0.05 13.8 0.0 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain Aa_trans PF01490.18 EFC38659.1 - 1.1e-11 44.1 14.2 5e-08 32.1 0.5 2.2 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein DUF1955 PF09205.10 EFC38659.1 - 0.23 11.2 0.2 0.36 10.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) YmdB PF13277.6 EFC38660.1 - 0.0014 18.0 0.0 0.0027 17.1 0.0 1.5 2 0 0 2 2 2 1 YmdB-like protein FUN14 PF04930.15 EFC38660.1 - 0.57 10.6 3.8 2.5 8.6 3.8 2.1 1 1 0 1 1 1 0 FUN14 family RdRP PF05183.12 EFC38661.1 - 6.1e-15 54.9 0.0 7.8e-15 54.5 0.0 1.4 1 1 0 1 1 1 1 RNA dependent RNA polymerase ThrE PF06738.12 EFC38662.1 - 1.6e-24 86.6 1.7 1.7e-22 80.0 1.7 2.3 1 1 0 1 1 1 1 Putative threonine/serine exporter ECF_trnsprt PF12822.7 EFC38662.1 - 0.0028 17.8 5.0 0.0042 17.2 5.0 1.3 1 0 0 1 1 1 1 ECF transporter, substrate-specific component ETRAMP PF09716.10 EFC38662.1 - 0.4 10.8 2.2 0.88 9.7 0.0 2.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TssN PF17555.2 EFC38662.1 - 0.68 9.3 7.8 1.1 8.6 7.8 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN Hist_deacetyl PF00850.19 EFC38663.1 - 6.7e-71 239.3 0.7 7.3e-70 235.9 0.0 2.1 1 1 1 2 2 2 1 Histone deacetylase domain DUF1256 PF06866.11 EFC38663.1 - 0.041 13.3 0.0 0.12 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) BID PF06393.11 EFC38664.1 - 0.0046 16.5 4.5 0.017 14.7 4.2 2.1 2 0 0 2 2 2 1 BH3 interacting domain (BID) DUF842 PF05811.13 EFC38664.1 - 0.48 10.1 11.4 3.7 7.3 4.1 2.4 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Uds1 PF15456.6 EFC38664.1 - 1.9 8.6 5.7 7.4 6.8 5.1 2.4 2 1 0 2 2 2 0 Up-regulated During Septation DUF4208 PF13907.6 EFC38664.1 - 4.8 7.7 9.3 0.85 10.1 2.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) DUF4419 PF14388.6 EFC38665.1 - 9.6e-103 343.7 0.7 1.1e-102 343.5 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) PRESAN PF09687.10 EFC38667.1 - 1.3 9.6 12.3 1.6 9.3 0.9 3.3 3 0 0 3 3 3 0 Plasmodium RESA N-terminal Biotin_lipoyl_2 PF13533.6 EFC38668.1 - 8.3e-05 22.3 0.0 0.0002 21.1 0.0 1.6 1 0 0 1 1 1 1 Biotin-lipoyl like HlyD_D23 PF16576.5 EFC38668.1 - 0.00065 19.0 0.1 0.00076 18.8 0.1 1.2 1 0 0 1 1 1 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl PF00364.22 EFC38668.1 - 0.0062 16.4 0.0 0.0095 15.7 0.0 1.4 1 1 0 1 1 1 1 Biotin-requiring enzyme Ras PF00071.22 EFC38669.1 - 8e-20 71.1 0.0 1.3e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38669.1 - 6.6e-19 68.3 0.0 1.4e-18 67.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC38669.1 - 0.00014 21.3 0.0 0.00024 20.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFC38669.1 - 0.00016 21.1 0.0 0.00026 20.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 EFC38669.1 - 0.0004 20.2 0.2 0.00089 19.1 0.2 1.6 1 0 0 1 1 1 1 F-box-like AAA_16 PF13191.6 EFC38669.1 - 0.036 14.4 0.0 0.22 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 EFC38669.1 - 0.053 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EFC38669.1 - 0.16 11.9 0.0 0.38 10.7 0.0 1.8 1 1 0 1 1 1 0 NACHT domain DUF2076 PF09849.9 EFC38669.1 - 0.19 11.7 2.9 0.14 12.2 1.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF553 PF04473.12 EFC38670.1 - 2.9e-05 23.6 0.1 5e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Transglutaminase-like domain Transglut_core PF01841.19 EFC38670.1 - 0.00048 20.6 0.0 0.0033 17.8 0.0 2.0 1 1 0 1 1 1 1 Transglutaminase-like superfamily Muraidase PF11860.8 EFC38670.1 - 0.054 13.7 0.0 0.43 10.8 0.0 2.0 2 0 0 2 2 2 0 N-acetylmuramidase NmrA PF05368.13 EFC38672.1 - 4.9e-17 62.3 0.1 8.5e-17 61.5 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC38672.1 - 1.8e-09 37.8 0.0 2.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC38672.1 - 4.1e-05 23.2 0.0 0.00026 20.5 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFC38672.1 - 0.0002 20.6 0.0 0.00032 19.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EFC38672.1 - 0.0002 20.4 0.1 0.00065 18.8 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC38672.1 - 0.00095 18.7 0.1 0.0052 16.2 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EFC38672.1 - 0.0017 17.8 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 EFC38672.1 - 0.009 15.2 0.8 0.031 13.4 0.1 1.9 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EFC38672.1 - 0.0098 16.2 0.0 0.03 14.6 0.0 1.9 3 0 0 3 3 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFC38672.1 - 0.015 15.2 0.0 0.049 13.5 0.0 2.0 2 1 0 2 2 2 0 KR domain Semialdhyde_dh PF01118.24 EFC38672.1 - 0.015 15.7 0.0 0.044 14.2 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EFC38672.1 - 0.025 14.7 0.0 0.062 13.4 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.18 EFC38672.1 - 0.028 14.7 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain AcylCoA_dehyd_C PF12186.8 EFC38672.1 - 0.059 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal RmlD_sub_bind PF04321.17 EFC38672.1 - 0.086 11.9 0.1 0.61 9.1 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain GFO_IDH_MocA PF01408.22 EFC38672.1 - 0.11 13.4 0.0 0.22 12.4 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ribosomal_S3_C PF00189.20 EFC38674.1 - 8.6e-23 80.7 3.9 1.4e-22 80.0 2.7 2.0 3 0 0 3 3 3 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 EFC38674.1 - 8.7e-14 51.1 0.7 1.9e-13 50.0 0.7 1.6 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 EFC38674.1 - 0.13 12.8 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Ins_P5_2-kin PF06090.12 EFC38675.1 - 4.2e-81 273.0 2.0 1.1e-80 271.6 2.0 1.6 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DUF603 PF04645.12 EFC38675.1 - 0.0041 16.8 0.2 1.1 8.9 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function, DUF603 SPG48 PF14764.6 EFC38675.1 - 0.016 15.7 0.4 4.5 7.8 0.1 3.2 3 0 0 3 3 3 0 AP-5 complex subunit, vesicle trafficking Trans_coact PF16805.5 EFC38675.1 - 0.017 15.2 0.1 1.1 9.4 0.0 2.7 2 1 0 2 2 2 0 Phage late-transcription coactivator zf-piccolo PF05715.13 EFC38675.1 - 0.62 10.3 4.7 6.7 6.9 0.0 2.8 3 0 0 3 3 3 0 Piccolo Zn-finger F-box PF00646.33 EFC38676.1 - 3.2e-07 30.1 0.1 7.4e-07 28.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC38676.1 - 5.6e-06 26.1 0.1 1.2e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like HPS3_N PF14761.6 EFC38677.1 - 8.3e-05 22.2 0.1 0.00018 21.1 0.1 1.6 1 0 0 1 1 1 1 Hermansky-Pudlak syndrome 3 DUF3295 PF11702.8 EFC38677.1 - 0.043 13.2 1.5 0.065 12.6 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Astro_capsid_p PF12226.8 EFC38677.1 - 0.074 12.2 4.8 0.12 11.5 4.8 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein ANAPC4_WD40 PF12894.7 EFC38677.1 - 0.085 13.2 0.3 6 7.2 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DNA_pol_phi PF04931.13 EFC38677.1 - 6.5 4.7 11.0 10 4.1 11.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi DHOase PF12890.7 EFC38678.1 - 0.035 14.0 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Dihydro-orotase-like CENP-T_C PF15511.6 EFC38679.1 - 2.7e-10 40.3 0.1 3.3e-10 40.0 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFC38679.1 - 2.3e-05 24.8 0.1 2.6e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EFC38679.1 - 7.3e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFC38679.1 - 0.00012 22.3 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFC38679.1 - 0.00014 22.1 0.2 0.00017 21.9 0.2 1.3 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EFC38679.1 - 0.00054 20.0 0.0 0.00066 19.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFC38679.1 - 0.007 16.3 0.1 0.0099 15.9 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated Ribosomal_S17e PF00833.18 EFC38679.1 - 0.029 14.3 0.2 0.035 14.0 0.2 1.2 1 0 0 1 1 1 0 Ribosomal S17 F-box PF00646.33 EFC38680.1 - 0.00065 19.5 0.6 0.0017 18.1 0.6 1.7 1 0 0 1 1 1 1 F-box domain adh_short PF00106.25 EFC38681.1 - 1.1e-32 113.1 0.3 1.4e-32 112.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC38681.1 - 1.3e-25 90.4 0.0 1.5e-25 90.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC38681.1 - 6.6e-08 32.7 0.1 8.5e-08 32.3 0.1 1.1 1 0 0 1 1 1 1 KR domain Terminase_3 PF04466.13 EFC38681.1 - 0.0059 16.1 0.0 0.009 15.6 0.0 1.2 1 0 0 1 1 1 1 Phage terminase large subunit NAD_binding_10 PF13460.6 EFC38681.1 - 0.011 15.7 0.0 0.016 15.1 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFC38681.1 - 0.012 15.1 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFC38681.1 - 0.02 14.1 0.7 0.1 11.7 0.1 2.1 1 1 0 2 2 2 0 Male sterility protein DUF2120 PF09893.9 EFC38681.1 - 0.038 14.1 0.1 0.063 13.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) NmrA PF05368.13 EFC38681.1 - 0.086 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family PseudoU_synth_2 PF00849.22 EFC38682.1 - 2.7e-15 56.8 0.0 4.8e-15 56.0 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase DUF4116 PF13475.6 EFC38683.1 - 1.6e-122 399.1 48.5 2e-17 62.6 0.1 9.9 2 2 10 12 12 12 12 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC38683.1 - 2.5e-26 92.6 4.9 2.5e-26 92.6 4.9 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38683.1 - 2.1e-09 37.1 0.2 4.7e-09 35.9 0.2 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase CBM60 PF16841.5 EFC38683.1 - 4e-05 23.9 3.7 0.11 13.0 0.1 5.0 3 2 2 5 5 5 1 Ca-dependent carbohydrate-binding module xylan-binding FTA2 PF13095.6 EFC38683.1 - 0.0015 18.2 1.2 0.21 11.2 0.1 2.9 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EFC38683.1 - 0.0024 17.2 0.0 0.0069 15.7 0.0 1.7 2 0 0 2 2 2 1 Kinase-like CPT_N PF16484.5 EFC38683.1 - 0.003 17.5 0.0 31 4.6 0.0 5.2 4 2 2 6 6 6 0 Carnitine O-palmitoyltransferase N-terminus FapA PF03961.13 EFC38683.1 - 0.0092 14.6 13.9 0.011 14.4 11.7 2.3 2 0 0 2 2 2 1 Flagellar Assembly Protein A RNA_pol_Rpb2_45 PF10385.9 EFC38683.1 - 0.05 13.9 1.2 2.5 8.4 0.1 3.6 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain FlxA PF14282.6 EFC38683.1 - 0.086 12.8 10.7 0.25 11.4 10.7 1.7 1 0 0 1 1 1 0 FlxA-like protein JAKMIP_CC3 PF16034.5 EFC38683.1 - 0.22 11.5 18.9 0.1 12.5 11.4 2.6 1 1 1 2 2 2 0 JAKMIP CC3 domain DUF3450 PF11932.8 EFC38683.1 - 0.23 10.7 8.1 0.46 9.8 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) NYD-SP28_assoc PF14775.6 EFC38683.1 - 0.52 10.5 17.2 1.5 9.0 6.4 4.2 2 2 2 4 4 4 0 Sperm tail C-terminal domain APG6_N PF17675.1 EFC38683.1 - 1.8 9.1 14.6 17 5.9 14.6 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Tropomyosin_1 PF12718.7 EFC38683.1 - 1.9 8.6 19.3 1.7 8.8 15.1 3.0 2 1 0 2 2 2 0 Tropomyosin like HAUS6_N PF14661.6 EFC38683.1 - 2.3 7.7 9.9 6.7 6.2 8.6 2.5 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TRAF_BIRC3_bd PF16673.5 EFC38683.1 - 2.5 7.9 11.5 3.4 7.5 0.1 3.2 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain AAA_11 PF13086.6 EFC38683.1 - 3.3 7.4 6.6 12 5.5 6.6 1.9 1 0 0 1 1 1 0 AAA domain Swi5 PF07061.11 EFC38683.1 - 3.5 7.8 14.6 0.88 9.7 6.6 3.2 2 0 0 2 2 2 0 Swi5 SlyX PF04102.12 EFC38683.1 - 7.3 7.3 8.7 50 4.6 1.2 3.0 1 1 0 1 1 1 0 SlyX AHSP PF09236.10 EFC38684.1 - 0.0044 17.4 0.4 0.075 13.5 0.1 2.6 2 0 0 2 2 2 1 Alpha-haemoglobin stabilising protein CorA PF01544.18 EFC38685.1 - 6.2e-34 117.6 2.2 4.4e-32 111.6 2.2 2.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein MIS13 PF08202.11 EFC38685.1 - 0.012 14.9 0.2 0.02 14.2 0.2 1.3 1 0 0 1 1 1 0 Mis12-Mtw1 protein family Ligase_CoA PF00549.19 EFC38685.1 - 0.012 15.4 0.0 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 CoA-ligase MotA_ExbB PF01618.16 EFC38685.1 - 0.035 13.9 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family JTB PF05439.12 EFC38685.1 - 0.12 12.4 1.5 0.23 11.5 0.1 2.3 2 0 0 2 2 2 0 Jumping translocation breakpoint protein (JTB) HECW1_helix PF18436.1 EFC38686.1 - 0.04 14.0 0.2 0.79 9.9 0.1 2.4 2 0 0 2 2 2 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 DUF2116 PF09889.9 EFC38686.1 - 0.063 13.3 4.6 0.39 10.7 0.4 3.1 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) MASE4 PF17158.4 EFC38686.1 - 0.069 12.4 23.3 0.092 12.0 8.3 2.8 1 1 2 3 3 3 0 Membrane-associated sensor, integral membrane domain SLATT_1 PF18181.1 EFC38686.1 - 0.18 11.7 1.2 4.5 7.2 0.5 2.8 2 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 EMP70 PF02990.16 EFC38686.1 - 1.4 7.5 20.3 2.1 6.9 20.3 1.3 1 0 0 1 1 1 0 Endomembrane protein 70 LRR_6 PF13516.6 EFC38687.1 - 3.3e-47 154.6 20.2 6.7e-06 25.7 0.0 11.7 12 0 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC38687.1 - 4.3e-29 100.1 9.4 1.6e-07 31.0 0.5 4.8 3 1 0 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC38687.1 - 2.5e-24 84.9 14.2 0.00015 22.1 0.1 7.8 2 2 8 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38687.1 - 2.1e-15 54.9 9.5 0.57 10.9 0.0 10.9 10 1 1 11 11 11 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC38687.1 - 8.1e-09 35.2 0.1 0.00012 21.7 0.0 3.6 1 1 1 3 3 3 2 Leucine-rich repeat F-box-like PF12937.7 EFC38687.1 - 8.7e-08 31.9 0.0 1.9e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC38687.1 - 2.3e-05 24.1 0.2 6.9e-05 22.6 0.2 1.8 1 0 0 1 1 1 1 F-box domain DUF5537 PF17690.1 EFC38687.1 - 0.14 11.8 0.2 0.31 10.7 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5537) RelB_leu_zip PF16180.5 EFC38687.1 - 0.71 9.9 2.0 29 4.8 0.1 3.4 2 1 2 4 4 4 0 RelB leucine zipper G-alpha PF00503.20 EFC38689.1 - 1.7e-51 175.5 5.1 2.4e-51 175.0 5.1 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC38689.1 - 3.1e-10 39.8 0.0 6.1e-06 25.8 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_29 PF13555.6 EFC38689.1 - 0.00061 19.5 0.0 0.0017 18.1 0.0 1.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain SRPRB PF09439.10 EFC38689.1 - 0.00063 19.2 0.0 0.021 14.3 0.0 2.3 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 EFC38689.1 - 0.0015 19.1 0.0 0.0053 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFC38689.1 - 0.0034 17.4 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFC38689.1 - 0.0035 17.9 0.1 0.0083 16.6 0.1 1.9 1 1 0 1 1 1 1 ABC transporter ATPase_2 PF01637.18 EFC38689.1 - 0.011 15.7 0.1 0.038 13.9 0.0 2.0 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Roc PF08477.13 EFC38689.1 - 0.095 12.9 0.0 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC38689.1 - 0.15 11.4 2.1 20 4.5 0.1 3.3 3 1 1 4 4 4 0 Gtr1/RagA G protein conserved region LpxD PF04613.14 EFC38690.1 - 0.0048 16.6 0.3 0.017 14.9 0.3 1.9 1 0 0 1 1 1 1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD CDC27 PF09507.10 EFC38690.1 - 0.068 12.5 38.0 0.084 12.3 38.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hamartin PF04388.12 EFC38690.1 - 0.31 9.7 17.1 0.32 9.6 17.1 1.0 1 0 0 1 1 1 0 Hamartin protein DUF4045 PF13254.6 EFC38690.1 - 7.1 6.2 33.0 9.7 5.7 33.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) VIR_N PF15912.5 EFC38690.1 - 7.8 6.0 19.3 10 5.6 19.3 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Metallophos PF00149.28 EFC38691.1 - 4.2e-12 47.0 0.4 7.4e-12 46.2 0.4 1.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC38691.1 - 1.2e-08 35.3 0.1 8.9e-07 29.2 0.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF3642 PF12182.8 EFC38691.1 - 0.21 11.9 1.2 0.59 10.4 0.0 2.3 3 0 0 3 3 3 0 Bacterial lipoprotein DUF4116 PF13475.6 EFC38693.1 - 4.1e-39 132.1 49.8 1.3e-07 31.2 0.4 11.0 7 3 4 11 11 11 11 Domain of unknown function (DUF4116) Snf7 PF03357.21 EFC38695.1 - 6.2e-31 107.3 21.4 6.2e-31 107.3 21.4 2.0 1 1 1 2 2 2 1 Snf7 DUF5082 PF16888.5 EFC38695.1 - 0.0015 18.8 7.2 0.0015 18.8 7.2 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF5082) PspA_IM30 PF04012.12 EFC38695.1 - 0.0086 15.7 18.3 0.019 14.5 16.9 2.0 1 1 0 1 1 1 1 PspA/IM30 family DUF3243 PF11588.8 EFC38695.1 - 0.014 15.7 0.2 0.092 13.1 0.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3243) WXG100 PF06013.12 EFC38695.1 - 0.032 14.5 4.0 2.8 8.3 0.8 2.8 1 1 0 2 2 2 0 Proteins of 100 residues with WXG DUF3573 PF12097.8 EFC38695.1 - 0.052 12.4 3.3 0.068 12.0 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF3138 PF11336.8 EFC38695.1 - 0.067 11.8 1.7 0.09 11.4 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DUF3791 PF12668.7 EFC38695.1 - 0.082 13.0 0.8 0.22 11.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) Synaptobrevin PF00957.21 EFC38695.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.7 2 1 0 2 2 2 0 Synaptobrevin RNA_pol_Rpb1_5 PF04998.17 EFC38695.1 - 5.5 6.3 8.0 8.3 5.7 8.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 DUF948 PF06103.11 EFC38695.1 - 9.6 6.5 9.1 2.8e+02 1.9 9.0 2.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) NHL PF01436.21 EFC38696.1 - 1.1e-38 129.3 11.9 0.00027 20.8 0.0 14.5 14 0 0 14 14 14 9 NHL repeat EGF_2 PF07974.13 EFC38696.1 - 1.2e-16 60.7 54.8 0.00018 21.8 6.5 4.8 4 0 0 4 4 4 4 EGF-like domain SGL PF08450.12 EFC38696.1 - 9.9e-10 38.4 10.8 0.0033 17.0 0.2 6.5 4 3 1 6 6 6 3 SMP-30/Gluconolactonase/LRE-like region GPS PF01825.21 EFC38696.1 - 5.8e-05 23.5 0.0 5.8e-05 23.5 0.0 2.5 2 0 0 2 2 1 1 GPCR proteolysis site, GPS, motif Phytase-like PF13449.6 EFC38696.1 - 0.0035 17.3 0.4 9 6.1 0.0 4.6 2 2 1 3 3 3 1 Esterase-like activity of phytase DAG1 PF05454.11 EFC38696.1 - 0.0075 15.7 4.1 0.017 14.5 4.1 1.6 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) GSDH PF07995.11 EFC38696.1 - 0.024 14.0 0.0 0.068 12.5 0.0 1.9 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase Arylesterase PF01731.20 EFC38696.1 - 0.1 12.8 6.8 5.9 7.2 0.1 5.5 5 0 0 5 5 5 0 Arylesterase EGF PF00008.27 EFC38696.1 - 0.1 12.9 44.5 0.052 13.9 2.0 5.3 5 0 0 5 5 4 0 EGF-like domain RIFIN PF02009.16 EFC38696.1 - 0.21 11.4 6.1 0.36 10.7 6.1 1.4 1 0 0 1 1 1 0 Rifin Syndecan PF01034.20 EFC38696.1 - 0.38 10.7 3.0 1.3 9.0 3.0 2.0 1 0 0 1 1 1 0 Syndecan domain DUF4116 PF13475.6 EFC38697.1 - 4.3e-28 96.8 0.3 3.5e-11 42.6 0.0 5.4 4 1 0 5 5 5 5 Domain of unknown function (DUF4116) SipA PF09052.10 EFC38698.1 - 0.062 12.9 0.3 0.097 12.3 0.3 1.3 1 0 0 1 1 1 0 SipA N-terminal domain HNH_5 PF14279.6 EFC38699.1 - 0.01 15.7 0.1 2.6 8.0 0.0 2.9 2 0 0 2 2 2 0 HNH endonuclease Neur_chan_memb PF02932.16 EFC38699.1 - 2.6 8.0 27.7 0.037 14.1 4.0 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region ADK_lid PF05191.14 EFC38699.1 - 4.2 7.4 9.0 1.1 9.3 0.0 3.2 3 0 0 3 3 3 0 Adenylate kinase, active site lid Ank_2 PF12796.7 EFC38700.1 - 0.0043 17.6 0.0 0.011 16.3 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC38700.1 - 0.0056 17.2 0.0 0.12 13.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC38700.1 - 0.031 14.8 0.1 0.36 11.5 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Alpha_kinase PF02816.18 EFC38701.1 - 2.2e-07 31.2 0.0 2.2e-07 31.2 0.0 2.7 3 1 1 4 4 4 1 Alpha-kinase family OmdA PF13376.6 EFC38701.1 - 0.14 12.1 0.0 18 5.4 0.1 2.7 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated DUF1451 PF07295.11 EFC38701.1 - 1.3 9.1 5.3 1.1 9.3 3.1 2.0 2 0 0 2 2 2 0 Zinc-ribbon containing domain PIN_4 PF13638.6 EFC38701.1 - 9.8 6.5 14.5 0.07 13.4 0.7 3.5 3 1 1 4 4 4 0 PIN domain Peptidase_M20 PF01546.28 EFC38702.1 - 1.1e-17 64.4 0.3 2.3e-17 63.4 0.3 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC38702.1 - 3.6e-06 26.9 0.0 7.8e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M50B PF13398.6 EFC38703.1 - 4.6e-42 143.9 16.6 7.7e-42 143.2 16.6 1.3 1 0 0 1 1 1 1 Peptidase M50B-like HPS3_Mid PF14762.6 EFC38703.1 - 1.5e-32 112.8 11.1 5.2e-19 68.3 2.1 3.5 2 1 2 4 4 4 3 Hermansky-Pudlak syndrome 3, middle region HPS3_N PF14761.6 EFC38703.1 - 0.00011 21.8 2.3 0.16 11.5 1.5 2.9 2 1 0 2 2 2 2 Hermansky-Pudlak syndrome 3 RNase_P_pop3 PF08228.11 EFC38703.1 - 0.065 13.3 0.0 0.22 11.6 0.0 1.9 1 0 0 1 1 1 0 RNase P subunit Pop3 ABC1 PF03109.16 EFC38704.1 - 2.9e-30 104.9 0.3 7.8e-30 103.5 0.3 1.8 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 EFC38704.1 - 0.00062 19.4 0.7 0.0012 18.5 0.1 1.7 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 EFC38704.1 - 0.0014 18.1 0.3 0.0042 16.5 0.3 1.8 1 0 0 1 1 1 1 Protein kinase domain SAM_2 PF07647.17 EFC38706.1 - 0.00048 20.2 0.0 0.00068 19.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Acylphosphatase PF00708.18 EFC38706.1 - 0.11 12.9 0.0 0.59 10.6 0.0 1.9 2 0 0 2 2 2 0 Acylphosphatase Aldo_ket_red PF00248.21 EFC38707.1 - 4.7e-82 275.5 0.1 5.4e-82 275.3 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Thioredoxin PF00085.20 EFC38708.1 - 4.9e-06 26.5 0.1 8.3e-05 22.5 0.0 2.4 2 1 0 2 2 2 1 Thioredoxin TssO PF17561.2 EFC38708.1 - 0.095 12.8 1.0 0.18 11.9 1.0 1.4 1 0 0 1 1 1 0 Type VI secretion system, TssO Wzz PF02706.15 EFC38708.1 - 2.3 8.5 6.0 7 7.0 6.0 1.9 1 1 0 1 1 1 0 Chain length determinant protein DUF5408 PF17402.2 EFC38710.1 - 0.0033 17.3 0.0 0.048 13.5 0.0 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5408) TRI5 PF06330.11 EFC38710.1 - 0.061 12.2 0.1 0.095 11.5 0.1 1.2 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) PUB PF09409.10 EFC38713.1 - 2.8e-17 62.4 0.1 6.5e-17 61.3 0.1 1.5 1 0 0 1 1 1 1 PUB domain LRRFIP PF09738.9 EFC38713.1 - 0.00033 20.2 4.6 0.00033 20.2 4.6 1.6 2 0 0 2 2 2 1 LRRFIP family SR-25 PF10500.9 EFC38713.1 - 0.0018 17.9 13.2 0.0026 17.4 13.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Folliculin PF11704.8 EFC38713.1 - 0.009 15.9 0.8 0.016 15.1 0.8 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport Pro_dh PF01619.18 EFC38713.1 - 0.028 14.0 0.2 0.036 13.6 0.2 1.1 1 0 0 1 1 1 0 Proline dehydrogenase Med12-LCEWAV PF12145.8 EFC38713.1 - 0.088 11.6 5.4 0.15 10.9 5.4 1.3 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain RGS PF00615.19 EFC38714.1 - 6.6e-10 39.3 8.8 1.1e-09 38.6 6.6 2.5 3 0 0 3 3 3 1 Regulator of G protein signaling domain GPS PF01825.21 EFC38714.1 - 3e-06 27.7 4.8 6.3e-06 26.6 4.8 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Bac_DNA_binding PF00216.21 EFC38714.1 - 0.59 10.4 2.5 5.7 7.2 0.2 2.6 2 0 0 2 2 2 0 Bacterial DNA-binding protein Fringe PF02434.16 EFC38715.1 - 2.4e-08 33.7 0.1 0.004 16.6 0.0 2.3 2 0 0 2 2 2 2 Fringe-like CAP_N PF01213.19 EFC38715.1 - 0.0088 15.6 0.1 0.016 14.7 0.1 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal HU-CCDC81_bac_2 PF18175.1 EFC38717.1 - 0.41 10.6 5.2 16 5.5 3.9 2.3 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 DUF3137 PF11335.8 EFC38718.1 - 0.0021 18.0 0.4 0.0073 16.2 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3137) CCD PF07860.11 EFC38718.1 - 1 9.4 6.2 2 8.5 1.5 2.3 2 0 0 2 2 2 0 WisP family C-Terminal Region USP8_dimer PF08969.11 EFC38719.1 - 0.0014 18.8 1.4 0.0044 17.2 1.4 1.9 1 0 0 1 1 1 1 USP8 dimerisation domain DUF445 PF04286.12 EFC38719.1 - 0.025 14.4 3.1 0.02 14.8 1.8 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF445) AIM3 PF17096.5 EFC38719.1 - 0.03 15.3 2.0 0.03 15.3 2.0 4.8 2 1 2 4 4 4 0 Altered inheritance of mitochondria protein 3 FlgN PF05130.12 EFC38720.1 - 0.015 15.9 4.9 0.015 15.9 4.9 2.8 1 1 1 2 2 2 0 FlgN protein DUF4279 PF14106.6 EFC38720.1 - 0.049 13.9 0.3 0.1 12.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) Mvb12 PF09452.10 EFC38720.1 - 0.21 12.0 1.8 1.1 9.8 0.2 2.5 2 2 0 2 2 2 0 ESCRT-I subunit Mvb12 DUF4407 PF14362.6 EFC38720.1 - 0.45 9.8 6.7 0.43 9.9 5.6 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Cob_adeno_trans PF01923.18 EFC38720.1 - 1.1 9.4 6.5 3.8 7.6 1.9 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase RapH_N PF18801.1 EFC38720.1 - 1.9 8.6 7.5 2 8.6 0.1 3.2 3 1 1 4 4 4 0 response regulator aspartate phosphatase H, N terminal IFT57 PF10498.9 EFC38720.1 - 2.3 7.1 17.7 0.082 11.9 11.1 1.7 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Exonuc_VII_L PF02601.15 EFC38720.1 - 6.6 6.2 13.5 14 5.1 13.5 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Malic_M PF03949.15 EFC38721.1 - 7.9e-86 287.5 0.0 1.1e-85 287.1 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFC38721.1 - 2.2e-46 157.9 0.3 4.6e-46 156.9 0.1 1.6 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Shikimate_DH PF01488.20 EFC38721.1 - 0.17 12.0 0.5 0.6 10.2 0.1 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_synthase PF02540.17 EFC38722.1 - 0.029 13.5 1.5 0.094 11.8 1.5 1.8 1 0 0 1 1 1 0 NAD synthase Kelch_4 PF13418.6 EFC38723.1 - 1.2e-22 79.7 1.9 4.1e-07 29.9 0.0 7.5 7 1 0 7 7 7 3 Galactose oxidase, central domain RhoGAP PF00620.27 EFC38723.1 - 1.1e-18 67.5 1.0 2e-18 66.7 1.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Kelch_3 PF13415.6 EFC38723.1 - 1.3e-18 66.8 4.8 0.0053 17.0 0.4 7.4 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC38723.1 - 5.4e-12 45.1 4.8 6.1e-07 28.9 0.0 5.6 6 1 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 EFC38723.1 - 7.4e-11 41.9 15.5 0.0021 18.3 1.7 7.5 5 2 1 6 6 6 3 Kelch motif Kelch_5 PF13854.6 EFC38723.1 - 1.7e-10 40.7 10.6 0.016 15.2 0.1 6.4 7 1 0 7 7 7 3 Kelch motif Kelch_2 PF07646.15 EFC38723.1 - 4.4e-06 26.5 8.4 0.18 11.9 0.1 5.8 6 0 0 6 6 6 2 Kelch motif RAG2 PF03089.14 EFC38723.1 - 0.071 12.1 0.0 0.22 10.5 0.0 1.8 2 0 0 2 2 2 0 Recombination activating protein 2 Mito_carr PF00153.27 EFC38724.1 - 1.7e-50 168.9 4.8 7.1e-16 57.9 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF637 PF04830.13 EFC38724.1 - 0.069 13.0 0.2 9.5 6.0 0.0 2.6 3 0 0 3 3 3 0 Possible hemagglutinin (DUF637) MmgE_PrpD PF03972.14 EFC38725.1 - 4.6 5.7 4.4 6.6 5.1 4.4 1.1 1 0 0 1 1 1 0 MmgE/PrpD family Kelch_3 PF13415.6 EFC38726.1 - 1.2e-11 44.6 4.1 0.0047 17.2 0.0 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC38726.1 - 1.4e-05 25.2 12.4 0.77 10.1 0.1 5.7 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 EFC38726.1 - 3.5e-05 23.7 11.4 0.49 10.4 0.1 5.7 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC38726.1 - 0.012 15.6 9.5 7.7 6.7 0.1 5.1 6 0 0 6 6 6 0 Kelch motif Kelch_5 PF13854.6 EFC38726.1 - 0.052 13.6 14.8 2.4 8.3 0.1 5.4 6 0 0 6 6 6 0 Kelch motif Kelch_1 PF01344.25 EFC38726.1 - 0.16 11.6 9.1 0.9 9.2 0.0 4.6 5 0 0 5 5 5 0 Kelch motif Cofilin_ADF PF00241.20 EFC38727.1 - 5.1e-19 68.3 0.0 5.5e-19 68.2 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ParBc_2 PF08857.11 EFC38728.1 - 2.1e-45 154.7 0.0 2.7e-45 154.4 0.0 1.1 1 0 0 1 1 1 1 Putative ParB-like nuclease SUKH_6 PF14568.6 EFC38728.1 - 0.027 14.9 0.5 0.054 13.9 0.5 1.5 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Staphostatin_B PF09023.10 EFC38728.1 - 0.065 13.3 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Staphostatin B F5_F8_type_C PF00754.25 EFC38729.1 - 0.002 18.2 0.0 0.003 17.7 0.0 1.2 1 0 0 1 1 1 1 F5/8 type C domain Sad1_UNC PF07738.13 EFC38729.1 - 0.0028 17.7 0.0 0.0042 17.1 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MAPEG PF01124.18 EFC38730.1 - 1.5e-06 28.2 0.7 2.3e-06 27.5 0.7 1.4 1 0 0 1 1 1 1 MAPEG family Mito_carr PF00153.27 EFC38731.1 - 2e-54 181.5 4.2 3.4e-18 65.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Patched PF02460.18 EFC38732.1 - 7.8e-73 245.9 32.8 1.1e-72 245.4 32.1 1.5 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 EFC38732.1 - 3e-49 166.8 10.8 3e-49 166.8 10.8 2.7 3 0 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 EFC38732.1 - 2e-06 27.0 34.5 0.00012 21.2 5.7 3.1 3 0 0 3 3 3 2 MMPL family Pep1_7 PF17232.2 EFC38732.1 - 0.16 12.4 0.0 8.8 6.9 0.0 2.8 3 0 0 3 3 3 0 Elicitor peptide 1-7 Bac_rhamnosid_C PF17390.2 EFC38733.1 - 4.9e-14 51.9 0.4 1.3e-13 50.6 0.4 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 EFC38733.1 - 1.7e-13 50.6 0.7 3.9e-10 39.5 0.1 2.9 2 1 0 2 2 2 2 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Laminin_G_3 PF13385.6 EFC38733.1 - 0.014 15.5 1.9 0.02 15.1 0.1 2.3 2 0 0 2 2 2 0 Concanavalin A-like lectin/glucanases superfamily GST_N_2 PF13409.6 EFC38734.1 - 1.4e-19 70.1 0.0 3.7e-19 68.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC38734.1 - 1.2e-09 38.0 0.0 5.2e-09 36.0 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC38734.1 - 1.6e-06 28.2 0.0 2.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC38734.1 - 0.0038 17.6 0.1 0.091 13.2 0.1 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain MatE PF01554.18 EFC38735.1 - 1.2e-45 155.1 41.7 5.6e-25 87.9 12.9 2.9 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 EFC38735.1 - 0.009 16.1 14.0 0.009 16.1 14.0 4.0 3 1 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain MscS_TM PF12794.7 EFC38735.1 - 0.012 14.5 0.6 0.012 14.5 0.6 3.2 3 1 1 4 4 4 0 Mechanosensitive ion channel inner membrane domain 1 MAP17 PF15807.5 EFC38735.1 - 0.088 13.0 0.1 0.088 13.0 0.1 1.9 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Vpu PF00558.19 EFC38735.1 - 0.22 11.3 1.4 0.77 9.6 1.4 1.9 1 0 0 1 1 1 0 Vpu protein AlaE PF06610.13 EFC38735.1 - 0.71 9.9 7.2 0.23 11.5 2.1 2.6 3 0 0 3 3 3 0 L-alanine exporter Adeno_E3B PF03376.14 EFC38735.1 - 0.82 9.9 6.2 13 6.1 0.7 3.0 2 0 0 2 2 2 0 Adenovirus E3B protein Sel1 PF08238.12 EFC38736.1 - 2e-15 56.9 13.7 8.6e-08 32.6 0.8 6.2 7 0 0 7 7 7 2 Sel1 repeat LRR_8 PF13855.6 EFC38736.1 - 0.038 13.8 1.6 0.39 10.5 0.2 2.8 2 1 0 2 2 2 0 Leucine rich repeat TPR_8 PF13181.6 EFC38736.1 - 0.16 12.3 5.4 11 6.6 0.0 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat LRR_4 PF12799.7 EFC38736.1 - 0.19 12.2 4.5 0.2 12.1 0.4 2.9 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) TPR_11 PF13414.6 EFC38736.1 - 0.31 10.8 4.6 3.6 7.4 0.3 4.0 4 0 0 4 4 4 0 TPR repeat TPR_1 PF00515.28 EFC38736.1 - 0.8 9.6 5.1 15 5.6 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SET PF00856.28 EFC38737.1 - 1.5e-08 35.2 0.0 4.7e-08 33.6 0.0 1.8 1 1 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 EFC38737.1 - 4.9e-07 30.5 0.2 9.2e-07 29.6 0.2 1.5 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Staphylokinase PF02821.16 EFC38737.1 - 0.23 11.9 2.5 0.35 11.3 0.0 2.4 3 0 0 3 3 3 0 Staphylokinase/Streptokinase family NHL PF01436.21 EFC38738.1 - 1.6e-21 75.2 16.8 6.8e-05 22.7 0.4 6.1 5 1 1 6 6 6 5 NHL repeat DUF5128 PF17170.4 EFC38738.1 - 1.6e-15 57.1 13.3 3.9e-08 32.8 0.6 3.4 2 1 1 4 4 4 3 6-bladed beta-propeller Arylesterase PF01731.20 EFC38738.1 - 4.7e-05 23.5 0.1 1.7 8.9 0.0 3.6 3 1 1 4 4 4 2 Arylesterase TolB_like PF15869.5 EFC38738.1 - 7e-05 22.2 0.3 0.051 12.8 0.0 2.8 2 1 1 3 3 3 2 TolB-like 6-blade propeller-like DUF4934 PF16288.5 EFC38738.1 - 0.00026 20.8 0.8 0.0092 15.9 0.1 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4934) SGL PF08450.12 EFC38738.1 - 0.0036 16.9 0.2 8.7 5.8 0.0 3.5 1 1 3 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region DUF87 PF01935.17 EFC38738.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain SH3_7 PF12914.7 EFC38738.1 - 0.15 12.2 0.0 3.5 7.8 0.0 2.6 3 0 0 3 3 3 0 SH3 domain of SH3b2 type Catalase PF00199.19 EFC38739.1 - 2.3e-196 652.4 0.3 2.8e-196 652.1 0.3 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EFC38739.1 - 8.3e-22 77.2 0.1 1.9e-21 76.0 0.1 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive PHD PF00628.29 EFC38740.1 - 1.5e-06 28.0 4.2 0.0016 18.3 0.1 2.5 2 0 0 2 2 2 2 PHD-finger E7 PF00527.18 EFC38740.1 - 0.13 12.5 0.3 0.39 11.0 0.3 1.8 1 0 0 1 1 1 0 E7 protein, Early protein Raftlin PF15250.6 EFC38740.1 - 1.1 7.9 7.9 2 7.1 7.9 1.4 1 0 0 1 1 1 0 Raftlin zf_UBZ PF18439.1 EFC38740.1 - 4.2 7.1 5.5 23 4.7 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger PRKCSH PF07915.13 EFC38741.1 - 2.8e-14 53.9 2.1 2.8e-14 53.9 2.1 2.8 3 1 0 3 3 3 1 Glucosidase II beta subunit-like protein CttA_N PF18244.1 EFC38741.1 - 0.012 16.1 1.1 0.08 13.4 1.1 2.4 1 0 0 1 1 1 0 Cellulose-binding protein CttA N-terminal domain DUF2845 PF11006.8 EFC38741.1 - 0.14 12.3 0.3 0.14 12.3 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2845) Carboxyl_trans PF01039.22 EFC38742.1 - 4.6e-183 609.4 0.5 5.4e-183 609.1 0.5 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EFC38742.1 - 0.029 13.9 0.2 0.22 11.0 0.0 2.1 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Polyketide_cyc2 PF10604.9 EFC38743.1 - 2.6e-12 47.2 0.0 3.1e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EFC38743.1 - 0.03 14.5 0.0 0.034 14.3 0.0 1.3 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport F-box-like PF12937.7 EFC38744.1 - 1.5e-07 31.2 0.1 3.2e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like TPR_11 PF13414.6 EFC38744.1 - 0.0033 17.1 0.1 3.2 7.5 0.0 2.9 2 0 0 2 2 2 2 TPR repeat F-box PF00646.33 EFC38744.1 - 0.0052 16.6 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 F-box domain VIR_N PF15912.5 EFC38744.1 - 0.013 15.1 17.4 0.034 13.7 17.4 1.7 1 0 0 1 1 1 0 Virilizer, N-terminal Euplotes_phero PF05842.11 EFC38744.1 - 0.26 11.8 14.1 0.67 10.5 3.0 4.5 2 1 1 3 3 3 0 Euplotes octocarinatus mating pheromone protein TPR_17 PF13431.6 EFC38744.1 - 0.29 11.6 6.0 7.7 7.2 0.3 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38744.1 - 0.39 11.1 6.3 23 5.5 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38744.1 - 0.65 10.3 4.4 1e+02 3.4 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF1477 PF07346.11 EFC38744.1 - 1.2 9.4 6.9 0.25 11.6 2.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1477) NAM-associated PF14303.6 EFC38744.1 - 6 7.6 22.1 0.02 15.6 10.9 2.6 3 0 0 3 3 3 0 No apical meristem-associated C-terminal domain GST_N_3 PF13417.6 EFC38745.1 - 1.2e-14 54.4 0.0 2.5e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC38745.1 - 1.6e-11 44.3 0.0 3.3e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFC38745.1 - 5.9e-10 39.3 0.0 1.1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_4 PF17172.4 EFC38745.1 - 0.011 16.4 0.0 0.021 15.6 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Glutaredoxin PF00462.24 EFC38745.1 - 0.015 15.5 0.0 0.39 11.0 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin GST_C_2 PF13410.6 EFC38745.1 - 0.076 13.1 0.0 0.18 11.8 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC38745.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ependymin PF00811.18 EFC38746.1 - 2.3e-12 47.3 0.0 3.4e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Ependymin DUF778 PF05608.12 EFC38747.1 - 1.4e-32 113.6 4.4 8.8e-22 78.4 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF778) DUF4796 PF16044.5 EFC38747.1 - 0.00099 18.8 0.2 0.0016 18.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4796) Peptidase_C97 PF05903.14 EFC38747.1 - 0.0057 16.5 1.9 0.0087 15.9 1.9 1.3 1 0 0 1 1 1 1 PPPDE putative peptidase domain Actin PF00022.19 EFC38748.1 - 1.1e-98 330.5 0.0 1.5e-97 326.8 0.0 1.9 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EFC38748.1 - 0.0088 16.4 0.0 0.24 11.8 0.0 2.4 2 1 0 2 2 2 1 Cell division protein FtsA RCC1_2 PF13540.6 EFC38749.1 - 2.1e-10 40.1 2.0 1.5e-05 24.7 0.0 4.6 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat FR47 PF08445.10 EFC38749.1 - 0.17 11.9 0.0 0.62 10.1 0.0 1.9 2 0 0 2 2 2 0 FR47-like protein RNase_H PF00075.24 EFC38750.1 - 0.00024 21.3 0.0 0.00063 19.9 0.0 1.8 1 0 0 1 1 1 1 RNase H Tim44 PF04280.15 EFC38751.1 - 2.3e-05 24.5 3.3 3.5e-05 24.0 2.8 1.5 1 1 0 1 1 1 1 Tim44-like domain Atg14 PF10186.9 EFC38751.1 - 1.2 8.1 8.1 2.8 6.9 8.1 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PH PF00169.29 EFC38755.1 - 7.7e-16 58.5 0.7 1.9e-15 57.3 0.7 1.7 1 0 0 1 1 1 1 PH domain Ribosomal_L34e PF01199.18 EFC38755.1 - 0.037 14.4 0.3 0.095 13.0 0.3 1.7 1 0 0 1 1 1 0 Ribosomal protein L34e NAPRTase_C PF17956.1 EFC38755.1 - 0.084 13.3 0.1 0.24 11.8 0.1 1.7 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain PH_11 PF15413.6 EFC38755.1 - 0.39 11.2 9.0 0.093 13.2 3.9 2.6 3 1 0 3 3 3 0 Pleckstrin homology domain Peptidase_S9_N PF02897.15 EFC38756.1 - 1e-64 218.9 15.6 2.1e-64 217.9 15.6 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 EFC38756.1 - 3e-55 187.0 0.0 5e-55 186.3 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFC38756.1 - 0.077 12.6 0.1 0.21 11.1 0.0 1.8 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Bactofilin PF04519.13 EFC38757.1 - 4.5e-18 65.4 33.4 0.026 14.8 8.0 8.3 1 1 7 8 8 8 7 Polymer-forming cytoskeletal RRM_DME PF15628.6 EFC38757.1 - 0.012 15.8 7.5 60 3.9 0.0 6.7 5 2 2 8 8 8 0 RRM in Demeter ADAM_spacer1 PF05986.14 EFC38757.1 - 0.014 15.4 11.4 20 5.3 0.0 6.6 6 2 3 9 9 9 0 ADAM-TS Spacer 1 DUF1495 PF07381.11 EFC38757.1 - 0.054 13.3 3.9 11 6.0 0.1 3.9 4 0 0 4 4 4 0 Winged helix DNA-binding domain (DUF1495) DUF3927 PF13064.6 EFC38757.1 - 0.17 11.9 1.3 0.49 10.4 1.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) tRNA_anti-like PF12869.7 EFC38757.1 - 0.5 10.0 2.9 34 4.0 0.1 3.6 4 0 0 4 4 4 0 tRNA_anti-like RhoGAP PF00620.27 EFC38758.1 - 1.8e-40 138.2 0.1 4.1e-40 137.1 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain C2 PF00168.30 EFC38758.1 - 2.8e-20 72.5 0.0 5.5e-20 71.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain PH PF00169.29 EFC38758.1 - 2.7e-06 27.8 1.3 6.5e-06 26.6 0.3 2.3 3 0 0 3 3 3 1 PH domain PH_13 PF16652.5 EFC38758.1 - 0.0089 15.8 1.7 0.76 9.6 1.3 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain EF-hand_1 PF00036.32 EFC38759.1 - 6.7e-40 131.7 20.6 1.9e-11 42.7 0.2 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFC38759.1 - 7.2e-34 116.1 8.7 1.6e-16 60.5 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC38759.1 - 1.4e-31 105.6 12.6 2e-09 36.6 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFC38759.1 - 6.7e-29 99.5 17.0 4.1e-12 45.8 0.7 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EFC38759.1 - 2.1e-28 96.5 19.0 1.8e-08 33.5 0.1 4.5 4 1 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EFC38759.1 - 4.2e-14 52.6 0.1 3.9e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC38759.1 - 1.8e-08 34.7 0.7 0.0025 18.1 0.1 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC38759.1 - 1.7e-06 27.9 8.5 0.0042 17.0 0.5 3.1 2 2 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EFC38759.1 - 6e-05 23.0 3.0 0.26 11.2 0.2 3.6 1 1 2 3 3 3 1 Caleosin related protein UPF0154 PF03672.13 EFC38759.1 - 0.0005 20.0 0.1 0.012 15.6 0.1 2.5 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0154) EF-hand_14 PF17959.1 EFC38759.1 - 0.0011 19.3 0.7 1.3 9.4 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 EFC38759.1 - 0.0051 17.7 0.2 1.3 9.9 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain DUF2666 PF10869.8 EFC38759.1 - 0.028 14.6 0.2 3.5 7.8 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) p25-alpha PF05517.12 EFC38759.1 - 0.045 13.9 0.5 0.73 10.0 0.2 2.8 1 1 2 3 3 3 0 p25-alpha SurA_N_2 PF13623.6 EFC38759.1 - 0.048 13.5 0.7 0.083 12.7 0.5 1.6 1 1 0 1 1 1 0 SurA N-terminal domain EFhand_Ca_insen PF08726.10 EFC38759.1 - 0.056 13.6 0.9 0.09 12.9 0.2 1.9 2 1 0 2 2 2 0 Ca2+ insensitive EF hand TerB PF05099.13 EFC38759.1 - 0.075 13.0 0.1 0.93 9.4 0.0 2.3 1 1 1 3 3 3 0 Tellurite resistance protein TerB DUF4497 PF14924.6 EFC38759.1 - 0.11 12.9 0.0 14 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) SUB1_ProdP9 PF18213.1 EFC38759.1 - 0.12 12.2 1.3 0.36 10.7 0.2 2.2 1 1 0 2 2 2 0 SUB1 protease Prodomain ProdP9 Glyco_hydro_56 PF01630.18 EFC38759.1 - 0.14 11.1 0.0 0.26 10.2 0.0 1.4 1 1 0 1 1 1 0 Hyaluronidase EF-hand_10 PF14788.6 EFC38759.1 - 0.29 11.0 7.6 2 8.4 0.4 3.4 2 2 1 3 3 3 0 EF hand Mst1_SARAH PF11629.8 EFC38759.1 - 1.1 9.4 5.2 1.6 8.9 0.2 3.3 3 1 1 4 4 4 0 C terminal SARAH domain of Mst1 DUF4834 PF16118.5 EFC38759.1 - 2.1 9.4 7.6 2.1 9.4 3.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) SUI1 PF01253.22 EFC38760.1 - 3.9e-18 65.8 0.4 4.8e-18 65.4 0.4 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF4534 PF15049.6 EFC38761.1 - 0.024 14.4 0.2 0.061 13.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4534) Syndecan PF01034.20 EFC38761.1 - 0.036 14.0 0.1 0.036 14.0 0.1 2.1 3 0 0 3 3 3 0 Syndecan domain PIN_4 PF13638.6 EFC38762.1 - 7.5e-07 29.5 0.1 8.9e-07 29.3 0.1 1.1 1 0 0 1 1 1 1 PIN domain Guanylate_cyc PF00211.20 EFC38763.1 - 3.6e-45 153.8 0.1 6.3e-45 153.0 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC38763.1 - 4.1e-12 46.3 0.0 4.6e-11 42.9 0.0 2.6 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC38763.1 - 0.00019 21.4 0.0 0.00044 20.2 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC38763.1 - 0.00048 20.3 0.0 0.001 19.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC38763.1 - 0.013 14.9 0.5 0.013 14.9 0.5 1.8 2 0 0 2 2 2 0 Heme NO binding associated DUF3546 PF12066.8 EFC38763.1 - 0.22 11.7 5.6 2.5 8.3 5.6 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3546) YqfD PF06898.11 EFC38764.1 - 0.0064 15.4 1.7 0.007 15.2 1.7 1.0 1 0 0 1 1 1 1 Putative stage IV sporulation protein YqfD COMPASS-Shg1 PF05205.12 EFC38764.1 - 0.6 10.8 7.7 0.35 11.6 3.8 2.1 2 1 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 UQ_con PF00179.26 EFC38765.1 - 1.8e-10 40.6 0.0 4.6e-08 32.8 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme P5-ATPase PF12409.8 EFC38766.1 - 0.016 15.3 0.6 0.02 15.0 0.6 1.2 1 0 0 1 1 1 0 P5-type ATPase cation transporter Tetraspanin PF00335.20 EFC38768.1 - 0.0017 18.1 0.2 0.0023 17.7 0.2 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF3561 PF12084.8 EFC38768.1 - 0.0022 18.0 0.4 0.0041 17.1 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3561) Pox_A14 PF05767.12 EFC38768.1 - 0.011 15.9 1.3 0.02 15.0 1.3 1.4 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 PITH PF06201.13 EFC38768.1 - 0.012 15.8 1.0 0.026 14.7 1.0 1.5 1 0 0 1 1 1 0 PITH domain POC3_POC4 PF10448.9 EFC38768.1 - 0.018 15.1 1.2 0.029 14.4 0.3 1.7 2 0 0 2 2 2 0 20S proteasome chaperone assembly proteins 3 and 4 NEMP PF10225.9 EFC38768.1 - 0.031 14.0 0.6 0.05 13.3 0.6 1.4 1 0 0 1 1 1 0 NEMP family DUF2207 PF09972.9 EFC38768.1 - 0.052 12.3 2.6 0.069 11.9 2.5 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) CRPA PF05745.11 EFC38768.1 - 0.057 13.4 0.6 0.084 12.9 0.6 1.3 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) Vpu PF00558.19 EFC38768.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.0 2 0 0 2 2 1 0 Vpu protein Pro_sub2 PF18513.1 EFC38768.1 - 2 8.7 6.5 0.72 10.1 0.6 2.6 2 1 1 3 3 3 0 Prodomain subtilisin 2 DUF2721 PF11026.8 EFC38768.1 - 5.8 6.8 5.8 1.2 9.0 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Lipase_3 PF01764.25 EFC38769.1 - 7.7e-25 87.4 0.5 2.2e-24 85.9 0.0 1.9 2 0 0 2 2 2 1 Lipase (class 3) DUF2974 PF11187.8 EFC38769.1 - 5.8e-05 22.8 0.2 0.00014 21.5 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PE-PPE PF08237.11 EFC38769.1 - 0.018 14.6 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain TraD_N PF12615.8 EFC38771.1 - 0.00027 21.7 0.8 0.2 12.5 0.0 2.2 2 0 0 2 2 2 2 F sex factor protein N terminal DUF996 PF06195.13 EFC38771.1 - 0.0029 17.9 1.6 0.0041 17.4 1.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF996) DUF3413 PF11893.8 EFC38771.1 - 0.006 15.8 3.1 0.0095 15.1 3.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3413) GpcrRhopsn4 PF10192.9 EFC38771.1 - 0.014 14.8 4.3 0.014 14.8 4.3 1.6 1 1 1 2 2 2 0 Rhodopsin-like GPCR transmembrane domain DUF5383 PF17355.2 EFC38771.1 - 0.021 15.2 0.0 0.52 10.7 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5383) DUF1772 PF08592.11 EFC38771.1 - 0.044 14.1 0.5 0.065 13.5 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) CD225 PF04505.12 EFC38771.1 - 0.36 11.0 4.4 0.69 10.1 3.7 1.8 1 1 0 1 1 1 0 Interferon-induced transmembrane protein zf-LITAF-like PF10601.9 EFC38771.1 - 5.1 7.4 5.2 2.2 8.6 0.1 2.5 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain C2 PF00168.30 EFC38772.1 - 0.00039 20.7 0.0 0.0011 19.3 0.0 1.6 1 1 1 2 2 2 1 C2 domain C2 PF00168.30 EFC38773.1 - 1.5e-23 83.0 0.0 2.3e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 EFC38774.1 - 3.3e-25 88.3 0.0 4.6e-25 87.9 0.0 1.2 1 0 0 1 1 1 1 C2 domain C2 PF00168.30 EFC38776.1 - 1.2e-23 83.4 0.0 1.7e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 C2 domain Pro-rich PF15240.6 EFC38776.1 - 0.0019 18.5 36.5 0.0024 18.2 36.5 1.2 1 0 0 1 1 1 1 Proline-rich HATPase_c PF02518.26 EFC38778.1 - 5.6e-21 75.1 0.7 2.5e-20 73.0 0.7 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC38778.1 - 2.6e-20 72.6 1.8 6.3e-18 65.0 0.2 3.1 3 0 0 3 3 3 2 Response regulator receiver domain HisKA PF00512.25 EFC38778.1 - 5.9e-12 45.4 0.2 1.7e-11 44.0 0.1 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Laminin_G_3 PF13385.6 EFC38779.1 - 4.9e-07 30.0 0.2 1.1e-06 28.9 0.2 1.6 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Oxidored_FMN PF00724.20 EFC38780.1 - 6.1e-78 262.5 0.0 7e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFC38780.1 - 0.0025 17.0 0.1 0.38 9.8 0.0 2.9 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) 3Beta_HSD PF01073.19 EFC38781.1 - 3.6e-05 22.9 0.0 4.4e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 EFC38781.1 - 7e-05 23.1 0.0 0.00011 22.4 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 EFC38781.1 - 0.0019 17.7 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC38781.1 - 0.0043 16.5 0.1 0.096 12.1 0.1 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFC38781.1 - 0.091 13.0 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pentapeptide PF00805.22 EFC38782.1 - 2.1e-40 135.9 57.8 2e-09 36.9 4.0 7.1 3 2 6 9 9 9 9 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC38782.1 - 3.8e-31 107.1 44.1 2.1e-12 47.1 5.5 4.9 1 1 3 5 5 5 5 Pentapeptide repeats (9 copies) TLD PF07534.16 EFC38782.1 - 4.6e-18 65.8 0.6 4.6e-18 65.8 0.6 2.5 2 0 0 2 2 2 1 TLD Pentapeptide_3 PF13576.6 EFC38782.1 - 4.6e-14 52.3 28.3 4e-05 23.7 2.1 5.9 3 1 2 5 5 5 5 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC38782.1 - 0.00073 19.8 0.1 0.0021 18.3 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain CfAFP PF05264.11 EFC38782.1 - 0.61 10.1 9.1 1.9 8.5 2.9 2.7 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) DUF4476 PF14771.6 EFC38783.1 - 7.6e-33 112.7 3.1 9.9e-24 83.5 0.4 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) PHA_synth_III_E PF09712.10 EFC38783.1 - 0.49 9.4 5.4 2.9 6.9 1.6 2.2 1 1 1 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) RGS PF00615.19 EFC38784.1 - 5.4e-05 23.5 2.7 0.00014 22.1 2.7 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF1958 PF09211.10 EFC38784.1 - 0.079 13.3 0.3 0.19 12.1 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1958) Guanylin PF02058.15 EFC38784.1 - 0.29 11.6 2.7 0.31 11.5 0.2 2.4 3 0 0 3 3 3 0 Guanylin precursor TRAM_LAG1_CLN8 PF03798.16 EFC38785.1 - 6.2e-25 88.1 23.5 6.2e-25 88.1 23.5 1.4 2 0 0 2 2 2 1 TLC domain UPF0242 PF06785.11 EFC38785.1 - 0.069 13.3 1.4 0.39 10.8 0.0 2.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF2207 PF09972.9 EFC38785.1 - 0.18 10.5 12.4 9.8 4.8 12.3 2.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) BUD22 PF09073.10 EFC38786.1 - 0.82 8.9 40.3 1.2 8.5 40.3 1.2 1 0 0 1 1 1 0 BUD22 Trypan_PARP PF05887.11 EFC38787.1 - 2e-05 24.5 59.7 0.00043 20.3 36.5 2.1 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Presenilin PF01080.17 EFC38787.1 - 6.8 5.3 15.9 6.5 5.4 15.9 1.1 1 0 0 1 1 1 0 Presenilin Trypsin_2 PF13365.6 EFC38788.1 - 0.022 15.7 0.0 0.081 13.8 0.0 1.9 1 1 0 1 1 1 0 Trypsin-like peptidase domain DUF3298 PF11738.8 EFC38788.1 - 0.17 12.9 0.2 30 5.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3298) MFS_1 PF07690.16 EFC38789.1 - 5.4e-23 81.5 12.1 2.3e-13 49.8 5.2 2.9 3 0 0 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFC38789.1 - 2.3e-10 39.6 29.8 2.2e-09 36.4 1.6 3.6 3 1 1 4 4 4 2 MFS/sugar transport protein PUCC PF03209.15 EFC38789.1 - 0.0012 17.9 7.0 0.074 12.0 0.0 3.0 3 1 0 3 3 3 2 PUCC protein Malic_M PF03949.15 EFC38791.1 - 4e-90 301.6 0.5 5.4e-90 301.1 0.5 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 EFC38791.1 - 3.1e-71 238.9 0.0 8.2e-71 237.6 0.0 1.7 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain Csm1 PF12539.8 EFC38791.1 - 0.0035 17.9 1.0 0.0084 16.7 0.0 2.2 3 0 0 3 3 3 1 Chromosome segregation protein Csm1/Pcs1 DUF3796 PF12676.7 EFC38791.1 - 0.055 13.9 0.2 0.11 13.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3796) p450 PF00067.22 EFC38792.1 - 6.8e-18 64.7 0.2 9.2e-18 64.2 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF4290 PF14123.6 EFC38792.1 - 0.067 12.7 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) UPF0203 PF05254.12 EFC38793.1 - 0.057 13.7 0.6 0.11 12.8 0.6 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) Myb_DNA-binding PF00249.31 EFC38794.1 - 9.5e-20 70.5 9.6 2.3e-07 30.9 0.4 3.8 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC38794.1 - 3.1e-19 69.0 11.1 1.4e-06 28.5 1.1 3.7 3 0 0 3 3 3 3 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFC38794.1 - 0.0031 17.7 5.5 1.4 9.1 0.0 3.7 1 1 2 3 3 3 2 SANT/Myb-like domain of DAMP1 MVP_shoulder PF11978.8 EFC38794.1 - 0.087 12.8 0.6 12 5.9 0.0 3.1 3 0 0 3 3 3 0 Shoulder domain p450 PF00067.22 EFC38795.1 - 4.2e-34 118.1 0.1 4.5e-34 118.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PAS_8 PF13188.7 EFC38795.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 PAS domain QueF_N PF14819.6 EFC38795.1 - 0.15 12.4 0.0 1.6 9.1 0.0 2.4 3 0 0 3 3 3 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term SIR2 PF02146.17 EFC38796.1 - 2.2e-35 122.1 0.0 3.2e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EFC38796.1 - 0.00051 19.8 0.0 0.39 10.5 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain zf-RING_5 PF14634.6 EFC38797.1 - 4.2e-09 36.2 5.3 8.5e-09 35.2 5.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFC38797.1 - 2.9e-07 30.7 8.6 6.6e-07 29.6 8.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFC38797.1 - 4.9e-05 23.1 8.2 0.00018 21.3 8.2 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC38797.1 - 9.9e-05 22.1 6.5 0.0001 22.1 4.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC38797.1 - 0.00034 20.4 7.6 0.0011 18.8 7.6 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC38797.1 - 0.00058 19.8 0.9 0.00058 19.8 0.9 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 EFC38797.1 - 0.0012 18.6 6.4 0.0053 16.5 3.1 2.6 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 EFC38797.1 - 0.03 14.2 13.2 0.073 12.9 8.3 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFC38797.1 - 0.049 13.7 5.0 0.29 11.2 4.7 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFC38797.1 - 0.5 10.2 5.3 1.4 8.8 5.3 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EFC38797.1 - 0.78 9.9 6.4 0.73 10.0 4.2 2.1 1 1 0 1 1 1 0 RING-variant domain zf-rbx1 PF12678.7 EFC38797.1 - 3.7 7.9 10.7 12 6.3 8.6 2.4 1 1 1 2 2 2 0 RING-H2 zinc finger domain Peptidase_C1 PF00112.23 EFC38799.1 - 1e-41 143.4 4.0 1.3e-41 143.1 4.0 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC38799.1 - 0.0016 18.3 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide RGS PF00615.19 EFC38800.1 - 3.7e-06 27.2 0.8 1.4e-05 25.3 0.8 2.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain p450 PF00067.22 EFC38801.1 - 4.9e-55 187.1 0.0 8.6e-38 130.3 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Histone PF00125.24 EFC38803.1 - 1.1e-40 139.0 4.2 1.1e-40 139.0 4.2 2.0 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFC38803.1 - 0.0038 17.3 0.1 0.008 16.3 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 EFC38803.1 - 0.022 15.0 0.1 0.053 13.8 0.1 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Hamartin PF04388.12 EFC38803.1 - 0.028 13.1 9.6 0.029 13.0 9.6 1.1 1 0 0 1 1 1 0 Hamartin protein TFIID-31kDa PF02291.15 EFC38803.1 - 0.041 13.9 0.2 0.069 13.2 0.2 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 EFC38803.1 - 0.1 13.0 0.1 0.18 12.2 0.1 1.3 1 0 0 1 1 1 0 CENP-S protein Nucleo_P87 PF07267.11 EFC38803.1 - 0.33 9.8 8.9 0.34 9.7 8.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ndc1_Nup PF09531.10 EFC38803.1 - 1.8 7.2 6.2 1.7 7.3 6.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF908 PF06012.12 EFC38803.1 - 2.3 7.6 9.1 2.5 7.4 9.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) RGS PF00615.19 EFC38805.1 - 1.7e-08 34.8 4.1 4.4e-08 33.4 4.1 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Thioredoxin_8 PF13905.6 EFC38805.1 - 0.0027 18.0 0.3 0.39 11.1 0.1 3.0 2 0 0 2 2 2 2 Thioredoxin-like Pkinase PF00069.25 EFC38807.1 - 7e-11 42.0 2.0 2.2e-10 40.4 2.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38807.1 - 0.0086 15.4 1.6 0.059 12.7 1.6 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase DUF5327 PF17261.2 EFC38807.1 - 0.12 13.1 0.2 0.4 11.5 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5327) FAM83 PF07894.12 EFC38808.1 - 0.12 11.9 3.4 0.22 11.1 3.4 1.4 1 0 0 1 1 1 0 FAM83 A-H BTHB PF18410.1 EFC38808.1 - 0.4 10.5 3.4 0.14 12.0 0.5 1.7 2 0 0 2 2 2 0 Basic tilted helix bundle domain F-box-like PF12937.7 EFC38809.1 - 0.075 12.9 0.1 0.2 11.5 0.0 1.8 2 0 0 2 2 2 0 F-box-like PB1 PF00564.24 EFC38810.1 - 0.0089 15.9 0.0 0.031 14.2 0.1 1.9 2 0 0 2 2 2 1 PB1 domain SBP_bac_3 PF00497.20 EFC38813.1 - 4.2e-13 49.2 0.0 5.4e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Put_Phosphatase PF06888.12 EFC38813.1 - 0.021 14.2 0.0 0.033 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative Phosphatase zf-RING_7 PF02591.15 EFC38813.1 - 0.044 14.0 0.5 5.6 7.2 0.0 2.3 2 0 0 2 2 2 0 C4-type zinc ribbon domain DapH_N PF08503.10 EFC38813.1 - 0.098 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate succinyltransferase N-terminal RGS PF00615.19 EFC38815.1 - 1.3e-06 28.7 7.0 3.8e-06 27.2 6.5 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF3137 PF11335.8 EFC38815.1 - 0.0042 17.0 1.7 0.02 14.8 1.7 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3137) DUF4231 PF14015.6 EFC38815.1 - 0.062 13.8 0.1 0.22 12.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) COX_ARM PF06481.14 EFC38815.1 - 0.084 12.8 0.8 0.85 9.6 0.2 2.6 2 0 0 2 2 2 0 COX Aromatic Rich Motif DUF5013 PF16405.5 EFC38817.1 - 0.00036 20.8 1.2 0.7 10.2 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF5013) Peptidase_S8_N PF16361.5 EFC38817.1 - 0.046 14.2 0.2 0.085 13.4 0.2 1.4 1 0 0 1 1 1 0 N-terminal of Subtilase family NHL PF01436.21 EFC38818.1 - 9.3e-10 38.0 5.2 0.0012 18.8 0.1 5.3 6 0 0 6 6 6 2 NHL repeat ELH PF02323.15 EFC38818.1 - 0.095 12.1 0.6 0.15 11.4 0.6 1.2 1 0 0 1 1 1 0 Egg-laying hormone precursor RHSP PF07999.11 EFC38818.1 - 0.1 11.4 0.1 0.15 10.8 0.1 1.2 1 0 0 1 1 1 0 Retrotransposon hot spot protein DUF4211 PF13926.6 EFC38819.1 - 3.9e-28 98.3 2.8 3.9e-28 98.3 2.8 4.3 4 2 0 4 4 4 1 Domain of unknown function (DUF4211) RNA_lig_T4_1 PF09511.10 EFC38820.1 - 4.6e-16 59.3 0.4 2.5e-15 56.9 0.4 2.2 1 1 0 1 1 1 1 RNA ligase ApoLp-III PF07464.11 EFC38820.1 - 0.047 13.8 4.6 0.074 13.1 2.0 2.4 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) ORF_2_N PF18492.1 EFC38820.1 - 0.083 13.1 0.0 0.21 11.8 0.0 1.7 1 0 0 1 1 1 0 Open reading frame 2 N-terminal domain Guanylate_cyc PF00211.20 EFC38821.1 - 3.8e-53 179.8 0.0 7.3e-53 178.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC38821.1 - 0.021 14.8 0.0 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 PAS fold HNOBA PF07701.14 EFC38821.1 - 0.049 13.1 0.3 0.19 11.1 0.1 2.0 2 0 0 2 2 2 0 Heme NO binding associated DUF3698 PF12479.8 EFC38821.1 - 0.19 12.3 0.7 6.2 7.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) PH PF00169.29 EFC38822.1 - 1.4e-12 48.1 1.1 8.5e-12 45.5 1.1 2.4 1 0 0 1 1 1 1 PH domain UDPGT PF00201.18 EFC38823.1 - 4.4e-06 25.8 0.0 0.00018 20.5 0.0 2.2 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 EFC38823.1 - 4e-05 23.7 0.0 9e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Pkinase PF00069.25 EFC38824.1 - 2.9e-52 177.6 4.8 7.4e-27 94.4 0.7 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38824.1 - 2.3e-43 148.4 5.1 1.1e-21 77.3 0.4 4.3 4 0 0 4 4 4 3 Protein tyrosine kinase LRR_6 PF13516.6 EFC38824.1 - 4e-06 26.5 3.5 0.017 15.2 0.0 4.8 4 0 0 4 4 4 2 Leucine Rich repeat LRR_8 PF13855.6 EFC38824.1 - 0.00079 19.1 0.7 0.00079 19.1 0.7 4.0 3 1 1 4 4 4 2 Leucine rich repeat DUF4135 PF13575.6 EFC38824.1 - 0.0058 16.0 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) LRR_4 PF12799.7 EFC38824.1 - 0.14 12.7 0.1 0.14 12.7 0.1 6.3 6 1 1 7 7 7 0 Leucine Rich repeats (2 copies) Apo-CIII PF05778.12 EFC38824.1 - 0.42 10.3 1.6 2.6 7.7 0.1 2.9 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) DUF5439 PF17507.2 EFC38824.1 - 0.63 10.3 3.5 0.87 9.9 1.2 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5439) DUF3671 PF12420.8 EFC38825.1 - 0.67 10.0 13.2 11 6.2 11.7 2.3 1 1 0 1 1 1 0 Protein of unknown function 2TM PF13239.6 EFC38825.1 - 6.2 7.2 9.0 51 4.3 9.0 2.3 1 1 0 1 1 1 0 2TM domain Sacchrp_dh_C PF16653.5 EFC38826.1 - 1.7e-69 234.9 0.0 6.6e-69 232.9 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 EFC38826.1 - 1.8e-21 76.8 0.1 2.7e-21 76.2 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFC38826.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 EFC38826.1 - 0.0046 17.5 0.0 0.0096 16.5 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AAA PF00004.29 EFC38827.1 - 7.4e-22 78.2 0.6 2.8e-20 73.1 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFC38827.1 - 1.9e-15 56.6 0.2 7.3e-15 54.7 0.1 2.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFC38827.1 - 4.6e-08 32.7 0.0 1.1e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFC38827.1 - 0.071 13.1 0.1 0.43 10.6 0.1 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Acyl-CoA_dh_M PF02770.19 EFC38828.1 - 1.4e-17 63.7 0.0 2.4e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFC38828.1 - 7.3e-10 39.2 0.0 1.8e-09 38.0 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ACOX PF01756.19 EFC38828.1 - 6.5e-08 32.3 0.2 1.3e-07 31.3 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase DUF3379 PF11859.8 EFC38828.1 - 0.026 13.9 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) Med31 PF05669.12 EFC38829.1 - 0.031 14.3 0.3 0.1 12.6 0.3 2.0 1 0 0 1 1 1 0 SOH1 POTRA PF07244.15 EFC38829.1 - 0.14 12.8 2.6 1.8 9.2 0.8 2.5 1 1 1 2 2 2 0 Surface antigen variable number repeat MALT1_Ig PF18703.1 EFC38829.1 - 0.16 11.9 3.0 0.22 11.5 1.8 1.8 1 1 1 2 2 2 0 MALT1 Ig-like domain XLF PF09302.11 EFC38829.1 - 3.9 7.6 11.0 0.31 11.2 3.4 2.3 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF805 PF05656.14 EFC38830.1 - 2.9 8.3 5.7 5 7.6 5.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF805) DUF4116 PF13475.6 EFC38831.1 - 7.9e-72 236.8 18.3 3.3e-15 55.5 0.3 6.7 6 1 0 6 6 6 5 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC38831.1 - 4.5e-25 88.5 7.1 4.5e-25 88.5 7.1 3.3 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38831.1 - 2.2e-08 33.7 0.2 6.9e-08 32.1 0.2 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase LOH1CR12 PF10158.9 EFC38831.1 - 0.081 12.9 2.3 0.36 10.9 0.0 2.9 3 0 0 3 3 3 0 Tumour suppressor protein RIO1 PF01163.22 EFC38832.1 - 1.2e-75 253.3 1.1 3.5e-75 251.8 1.1 1.9 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFC38832.1 - 0.0022 18.0 0.0 0.033 14.1 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Peptidase_M24_C PF16188.5 EFC38832.1 - 0.043 13.9 0.1 6.5 6.9 0.1 3.4 4 0 0 4 4 4 0 C-terminal region of peptidase_M24 Pkinase_fungal PF17667.1 EFC38832.1 - 0.36 9.5 7.0 0.027 13.3 1.2 2.3 2 1 0 2 2 2 0 Fungal protein kinase TauE PF01925.19 EFC38833.1 - 2.8e-27 95.9 23.4 4.2e-14 52.8 0.0 2.3 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE DUF3487 PF11990.8 EFC38833.1 - 0.044 13.7 0.3 0.044 13.7 0.3 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3487) Baculo_11_kDa PF06143.11 EFC38833.1 - 3.1 7.4 8.2 15 5.2 0.3 2.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family QCR10 PF09796.9 EFC38833.1 - 9.5 6.4 9.7 1.5 8.9 0.8 3.3 2 1 1 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) PIG-P PF08510.12 EFC38834.1 - 0.022 14.7 5.0 0.034 14.1 5.0 1.6 1 1 0 1 1 1 0 PIG-P SURF6 PF04935.12 EFC38835.1 - 0.39 10.5 24.3 0.052 13.4 8.2 2.4 2 0 0 2 2 2 0 Surfeit locus protein 6 PBP1_TM PF14812.6 EFC38835.1 - 8.1 6.9 12.5 3.3 8.2 3.6 2.8 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_C26 PF07722.13 EFC38836.1 - 9.1e-15 55.0 0.0 6.9e-14 52.1 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 EFC38836.1 - 8.2e-09 35.5 0.0 1.3e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I LRR_6 PF13516.6 EFC38837.1 - 1e-09 37.7 7.3 9.5e-05 22.2 0.1 5.5 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 EFC38837.1 - 3.5e-08 33.6 17.9 0.077 13.5 0.6 4.9 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38837.1 - 0.0032 17.2 16.8 0.41 10.5 3.5 5.1 1 1 3 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC38837.1 - 0.0099 16.3 6.8 4.7 8.2 0.0 4.9 3 1 0 3 3 3 2 Leucine Rich Repeat Pyrid_oxidase_2 PF13883.6 EFC38838.1 - 0.12 12.4 3.7 0.2 11.6 3.5 1.5 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Mito_carr PF00153.27 EFC38839.1 - 2.5e-47 158.7 3.2 2.8e-18 65.6 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Thioredoxin PF00085.20 EFC38840.1 - 2.9e-37 126.8 1.5 1.3e-27 95.8 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EFC38840.1 - 1.8e-08 34.5 2.4 1.8e-08 34.5 2.4 1.7 1 1 1 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EFC38840.1 - 2.4e-08 33.7 4.2 0.0022 17.4 2.5 2.4 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFC38840.1 - 2.6e-08 34.3 1.4 2.8e-07 31.0 0.0 2.6 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFC38840.1 - 0.00084 19.6 0.5 0.18 12.1 0.0 3.4 2 1 1 3 3 3 1 Thioredoxin-like Glutaredoxin PF00462.24 EFC38840.1 - 0.071 13.3 1.4 0.63 10.3 0.5 2.9 2 1 0 2 2 2 0 Glutaredoxin Thioredoxin_7 PF13899.6 EFC38840.1 - 0.13 12.5 0.7 0.36 11.1 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin-like Voltage_CLC PF00654.20 EFC38841.1 - 1.2e-44 153.1 27.9 3.2e-44 151.6 27.9 1.6 1 1 0 1 1 1 1 Voltage gated chloride channel Sfi1 PF08457.10 EFC38843.1 - 1.8e-06 26.8 77.2 0.001 17.7 33.7 5.1 2 1 2 4 4 4 4 Sfi1 spindle body protein Radial_spoke PF04712.12 EFC38844.1 - 0.21 10.5 13.7 0.8 8.6 13.0 2.3 1 1 0 1 1 1 0 Radial spokehead-like protein YqfQ PF14181.6 EFC38844.1 - 1.4 9.1 6.0 2 8.6 6.0 1.2 1 0 0 1 1 1 0 YqfQ-like protein DUF489 PF04356.12 EFC38847.1 - 0.026 14.6 0.5 0.062 13.3 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF489) Gly_acyl_tr_C PF08444.10 EFC38847.1 - 0.17 12.1 0.4 1.2 9.4 0.0 2.6 2 1 1 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region DUF641 PF04859.12 EFC38848.1 - 0.79 10.1 16.5 0.24 11.7 1.0 3.2 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) RasGAP PF00616.19 EFC38849.1 - 8.2e-28 97.5 0.8 3.4e-24 85.7 0.0 4.3 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EFC38849.1 - 5.7e-19 68.6 2.3 5.7e-19 68.6 2.3 3.1 3 0 0 3 3 3 1 Divergent CRAL/TRIO domain DUF4047 PF13256.6 EFC38849.1 - 0.13 12.5 3.4 0.81 9.9 0.9 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) UNC45-central PF11701.8 EFC38849.1 - 1.4 8.8 8.4 0.76 9.7 0.4 4.5 5 0 0 5 5 5 0 Myosin-binding striated muscle assembly central ERAP1_C PF11838.8 EFC38850.1 - 1.6e-18 67.4 0.0 1.8e-18 67.2 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain LRR_6 PF13516.6 EFC38851.1 - 1.1e-32 109.2 3.2 3.8e-05 23.4 0.1 6.3 6 0 0 6 6 6 6 Leucine Rich repeat LRR_4 PF12799.7 EFC38851.1 - 1.8e-20 72.7 13.8 3e-05 24.3 0.3 4.6 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38851.1 - 5.6e-18 64.4 3.1 4.8e-09 35.8 0.5 3.2 2 1 1 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EFC38851.1 - 5.2e-12 44.6 0.1 8.5 7.4 0.0 6.7 7 0 0 7 7 7 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC38851.1 - 2.7e-06 27.0 0.1 0.054 13.0 0.0 2.0 1 1 1 2 2 2 2 Leucine-rich repeat ApoB100_C PF12491.8 EFC38851.1 - 0.00014 21.7 5.1 4.4 7.4 0.0 5.1 4 2 2 6 6 6 1 Apolipoprotein B100 C terminal CLU_N PF15044.6 EFC38851.1 - 0.00085 19.6 3.5 3.8 7.9 0.1 4.0 1 1 4 5 5 5 1 Mitochondrial function, CLU-N-term DUF4347 PF14252.6 EFC38851.1 - 0.0013 18.7 0.2 24 4.7 0.0 4.6 1 1 5 6 6 6 0 Domain of unknown function (DUF4347) DUF1825 PF08855.10 EFC38851.1 - 0.0059 16.5 2.4 1.9 8.5 0.1 2.9 2 1 0 2 2 2 2 Domain of unknown function (DUF1825) CBM32 PF18344.1 EFC38851.1 - 0.0089 15.9 3.3 36 4.3 0.1 5.1 5 1 1 6 6 6 0 Carbohydrate binding module family 32 DUF244 PF03112.14 EFC38851.1 - 0.03 14.2 0.1 0.13 12.1 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized protein family (ORF7) DUF 2OG-FeII_Oxy_3 PF13640.6 EFC38852.1 - 3e-07 31.2 0.0 6.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RNase_J_C PF17770.1 EFC38852.1 - 0.76 10.9 0.0 0.76 10.9 0.0 3.5 2 1 0 2 2 2 0 Ribonuclease J C-terminal domain SOBP PF15279.6 EFC38852.1 - 5 7.6 11.2 11 6.5 11.2 1.5 1 0 0 1 1 1 0 Sine oculis-binding protein AAA_11 PF13086.6 EFC38852.1 - 6.1 6.5 20.1 1.8 8.3 16.7 1.8 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EFC38853.1 - 3e-106 353.8 0.0 4.4e-106 353.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 EFC38853.1 - 5.1e-42 142.6 0.0 1e-41 141.6 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 EFC38853.1 - 2.7e-16 59.8 2.8 2.7e-16 59.8 2.8 2.3 2 1 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Sad1_UNC PF07738.13 EFC38854.1 - 6.6e-28 97.4 0.9 2.3e-27 95.6 0.9 2.0 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 EFC38854.1 - 3.9e-05 23.8 0.1 0.00031 20.8 0.0 2.6 2 0 0 2 2 2 1 F5/8 type C domain Fur_reg_FbpB PF13040.6 EFC38854.1 - 0.35 10.4 5.2 5.1 6.7 0.1 2.9 2 0 0 2 2 2 0 Fur-regulated basic protein B T6PP_N PF18572.1 EFC38854.1 - 3.6 7.5 13.2 5.4 6.9 0.6 3.2 3 0 0 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Ac76 PF05814.11 EFC38854.1 - 5.1 7.2 11.5 0.24 11.4 0.5 3.4 3 0 0 3 3 3 0 Orf76 (Ac76) LRR_6 PF13516.6 EFC38855.1 - 1.5e-25 87.0 0.0 1.7e-05 24.5 0.0 4.1 4 0 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 EFC38855.1 - 8.4e-12 45.1 1.1 1.2e-05 25.5 0.0 2.8 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC38855.1 - 2.4e-11 43.2 4.2 4.6e-08 32.7 0.5 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFC38855.1 - 2.1e-07 30.5 0.0 2.2 9.2 0.0 4.1 4 0 0 4 4 4 2 Leucine Rich Repeat ApoB100_C PF12491.8 EFC38855.1 - 0.028 14.4 2.7 12 6.0 0.2 3.2 1 1 2 3 3 3 0 Apolipoprotein B100 C terminal Spidroin_N PF16763.5 EFC38855.1 - 0.069 13.2 0.8 5 7.2 0.1 2.5 1 1 1 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term NKWYS PF10364.9 EFC38855.1 - 0.085 13.0 0.2 0.53 10.4 0.1 1.9 1 1 1 2 2 2 0 Putative capsular polysaccharide synthesis protein m04gp34like PF12216.8 EFC38856.1 - 0.012 15.2 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 Immune evasion protein DUF3117 PF11314.8 EFC38856.1 - 0.045 13.6 0.2 0.083 12.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3117) DUF5367 PF17329.2 EFC38856.1 - 0.072 13.2 1.1 0.13 12.4 1.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5367) Insulin_TMD PF17870.1 EFC38856.1 - 1.9 8.6 6.0 4.7 7.4 6.0 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Aa_trans PF01490.18 EFC38857.1 - 8.4e-50 169.7 32.1 1.5e-49 168.8 32.1 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1129 PF06570.11 EFC38857.1 - 0.057 12.9 0.2 0.057 12.9 0.2 4.4 4 1 0 4 4 4 0 Protein of unknown function (DUF1129) SLATT_1 PF18181.1 EFC38857.1 - 1.2 9.0 4.5 15 5.5 0.0 3.1 4 0 0 4 4 4 0 SMODS and SLOG-associating 2TM effector domain 1 Orf78 PF06024.12 EFC38857.1 - 1.6 9.1 5.4 2.2 8.6 0.1 3.4 3 0 0 3 3 3 0 Orf78 (ac78) WD40 PF00400.32 EFC38858.1 - 9.9e-28 95.8 19.5 2.1e-06 28.3 0.2 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC38858.1 - 1.7e-14 53.9 2.0 0.0073 16.6 0.0 4.4 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC38858.1 - 6e-09 35.7 2.7 0.19 11.0 0.0 4.3 3 1 1 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 EFC38858.1 - 1.1e-05 24.6 1.1 0.053 12.5 0.1 2.7 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFC38858.1 - 0.0014 17.3 1.1 1.3 7.6 0.1 2.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 TGBp3 PF02495.17 EFC38858.1 - 0.13 11.9 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 Triple gene block 3 PKD PF00801.20 EFC38858.1 - 0.15 11.9 1.4 0.71 9.8 0.1 2.5 2 0 0 2 2 2 0 PKD domain F-box-like PF12937.7 EFC38860.1 - 0.001 18.9 0.6 0.0022 17.9 0.6 1.5 1 0 0 1 1 1 1 F-box-like Ras PF00071.22 EFC38861.1 - 5.1e-61 205.0 0.1 6e-61 204.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38861.1 - 1.7e-32 112.2 0.0 2.7e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC38861.1 - 2.2e-13 50.0 0.0 2.7e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC38861.1 - 4.2e-05 23.6 0.0 7.8e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC38861.1 - 4.3e-05 23.1 0.1 0.0016 18.0 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC38861.1 - 0.00038 19.9 0.0 0.00048 19.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFC38861.1 - 0.0013 18.6 0.1 1.1 9.2 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EFC38861.1 - 0.006 16.4 0.0 0.17 11.6 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EFC38861.1 - 0.023 14.1 0.0 0.067 12.6 0.0 1.6 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EFC38861.1 - 0.026 14.8 0.1 0.073 13.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain TetR_C_16 PF17920.1 EFC38861.1 - 0.098 12.9 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain NACHT PF05729.12 EFC38861.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF1863 PF08937.11 EFC38861.1 - 0.12 12.7 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) AAA_16 PF13191.6 EFC38861.1 - 0.19 12.1 0.0 0.28 11.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain EF-hand_1 PF00036.32 EFC38862.1 - 0.00032 20.0 8.4 0.00046 19.5 0.9 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFC38862.1 - 0.00074 19.3 1.5 0.011 15.5 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 EFC38862.1 - 0.0018 18.6 1.3 0.014 15.8 0.1 2.2 2 1 0 2 2 2 1 EF-hand domain pair Cas_Csy1 PF09611.10 EFC38862.1 - 0.16 11.0 0.1 0.22 10.6 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy1) EF-hand_5 PF13202.6 EFC38862.1 - 2.2 7.9 5.8 0.4 10.3 0.4 2.2 2 0 0 2 2 2 0 EF hand Strumpellin PF10266.9 EFC38863.1 - 0 1346.8 43.6 0 1036.1 18.5 3.1 2 1 1 3 3 3 3 Hereditary spastic paraplegia protein strumpellin NOD PF06816.13 EFC38863.1 - 0.056 13.1 0.0 1.3 8.7 0.0 2.6 2 0 0 2 2 2 0 NOTCH protein GPI2 PF06432.11 EFC38864.1 - 0.042 13.3 0.0 9.8 5.5 0.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase START PF01852.19 EFC38865.1 - 3.7e-10 39.6 0.0 5.8e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 START domain RGS PF00615.19 EFC38865.1 - 9.3e-10 38.8 5.8 9.3e-10 38.8 5.8 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF1298 PF06974.13 EFC38868.1 - 1.5e-34 119.0 0.0 3.5e-34 117.8 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 EFC38868.1 - 0.012 15.4 0.0 0.28 10.9 0.0 2.5 2 1 0 2 2 2 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 EFC38868.1 - 0.015 14.0 0.0 0.062 12.0 0.1 1.8 2 0 0 2 2 2 0 Condensation domain FGFR3_TM PF18123.1 EFC38868.1 - 0.2 11.2 3.4 0.54 9.8 3.4 1.8 1 0 0 1 1 1 0 Fibroblast growth factor receptor 3 transmembrane domain LRR_4 PF12799.7 EFC38869.1 - 3.4 8.2 10.9 58 4.3 0.1 5.0 4 1 0 5 5 5 0 Leucine Rich repeats (2 copies) Polbeta PF18765.1 EFC38870.1 - 0.012 15.7 0.2 0.1 12.7 0.2 2.6 1 1 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Pkinase PF00069.25 EFC38871.1 - 8.7e-10 38.4 8.5 2.4e-09 37.0 8.5 1.8 1 1 0 1 1 1 1 Protein kinase domain MMR_HSR1 PF01926.23 EFC38872.1 - 1.1e-05 25.5 0.2 7e-05 22.9 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC38872.1 - 0.0066 15.9 0.1 0.04 13.3 0.0 2.2 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFC38872.1 - 0.033 13.7 0.0 0.066 12.7 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B Med25 PF11232.8 EFC38872.1 - 7.9 6.4 10.5 0.079 12.9 1.2 2.4 3 1 0 3 3 3 0 Mediator complex subunit 25 PTOV activation and synapsin 2 DUF2263 PF10021.9 EFC38873.1 - 2.9e-12 47.2 0.0 5.5e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) RGS PF00615.19 EFC38874.1 - 6.1e-12 45.9 1.5 6.1e-12 45.9 1.5 2.0 2 1 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC38874.1 - 0.017 14.8 0.1 0.036 13.8 0.1 1.6 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Adipogenin PF15202.6 EFC38874.1 - 0.19 11.8 1.2 0.84 9.7 1.2 2.1 1 0 0 1 1 1 0 Adipogenin DUF4116 PF13475.6 EFC38875.1 - 8.8e-52 172.6 30.8 3e-10 39.7 0.1 8.5 6 2 2 8 8 8 8 Domain of unknown function (DUF4116) S_layer_C PF05124.12 EFC38875.1 - 0.18 11.8 3.0 6.6 6.7 0.1 2.4 2 0 0 2 2 2 0 S-layer like family, C-terminal region ubiquitin PF00240.23 EFC38876.1 - 9.5e-24 83.0 0.1 1.7e-23 82.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC38876.1 - 4.6e-10 39.2 0.1 7.7e-10 38.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFC38876.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC38876.1 - 0.12 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain RGS PF00615.19 EFC38877.1 - 4.5e-07 30.1 4.1 1.5e-06 28.4 4.1 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Phospholamban PF04272.14 EFC38877.1 - 1.1 8.8 6.3 0.32 10.5 0.5 2.6 2 0 0 2 2 2 0 Phospholamban Gln-synt_C PF00120.24 EFC38879.1 - 2.2e-93 313.0 0.0 2.6e-93 312.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EFC38879.1 - 5.8e-09 35.6 1.3 4.8e-08 32.6 0.0 2.6 2 1 1 3 3 3 1 Glutamine synthetase, beta-Grasp domain Sel1 PF08238.12 EFC38880.1 - 3.3e-64 211.9 24.8 3.2e-09 37.2 0.3 8.3 8 0 0 8 8 8 8 Sel1 repeat DUF5344 PF17279.2 EFC38880.1 - 0.011 16.3 1.0 12 6.5 0.2 4.1 2 1 2 4 4 4 0 Family of unknown function (DUF5344) TPR_16 PF13432.6 EFC38880.1 - 0.011 16.4 2.2 0.24 12.1 0.1 3.2 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38880.1 - 0.037 14.7 1.3 3.7 8.4 0.0 4.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC38880.1 - 1.1 9.0 11.2 7.3 6.4 0.2 5.1 5 2 0 5 5 5 0 TPR repeat TPR_10 PF13374.6 EFC38880.1 - 8.5 6.4 5.3 73 3.4 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat EF-hand_7 PF13499.6 EFC38881.1 - 4.2e-08 33.5 0.7 7.7e-08 32.7 0.7 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFC38881.1 - 5.8e-08 31.7 0.0 0.0001 21.6 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFC38881.1 - 2.3e-06 27.1 0.2 0.001 18.8 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_3 PF09069.11 EFC38881.1 - 2.8e-06 27.7 0.1 0.00015 22.2 0.1 2.4 1 1 0 1 1 1 1 EF-hand EF-hand_5 PF13202.6 EFC38881.1 - 0.0001 21.6 0.1 0.13 11.8 0.0 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC38881.1 - 0.039 13.8 0.0 11 6.0 0.0 2.8 3 0 0 3 3 3 0 EF-hand domain pair p450 PF00067.22 EFC38882.1 - 1.8e-60 205.0 0.1 1.8e-60 205.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 VWD PF00094.25 EFC38883.1 - 4.3e-06 27.1 0.7 9.4e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type D domain Ferritin PF00210.24 EFC38883.1 - 0.098 12.6 0.1 0.098 12.6 0.1 3.7 2 2 2 4 4 4 0 Ferritin-like domain MitMem_reg PF13012.6 EFC38883.1 - 0.61 10.5 13.0 0.51 10.8 0.1 3.4 2 1 0 3 3 3 0 Maintenance of mitochondrial structure and function TPR_2 PF07719.17 EFC38884.1 - 2.4e-13 49.1 18.5 2.5e-06 27.1 0.5 8.6 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC38884.1 - 1.1e-09 38.8 0.0 3.6e-05 24.3 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38884.1 - 3.9e-09 36.7 6.4 2.2e-07 31.1 0.3 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38884.1 - 7e-09 35.8 2.6 0.0082 16.7 0.2 5.7 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC38884.1 - 7.2e-09 36.0 0.5 0.00011 22.6 0.1 4.7 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38884.1 - 4e-08 32.8 25.7 0.00024 21.1 0.5 8.0 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC38884.1 - 6.1e-07 29.5 0.0 0.0015 18.6 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC38884.1 - 6.4e-07 29.0 3.9 0.0044 16.9 0.0 6.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38884.1 - 6.5e-07 28.9 25.8 2e-06 27.3 0.5 7.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38884.1 - 6.6e-07 29.3 10.3 0.00037 20.7 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC38884.1 - 6.6e-05 23.4 0.5 2.3 9.3 0.1 5.5 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38884.1 - 7.4e-05 22.5 6.8 0.066 13.1 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC38884.1 - 0.00021 21.5 11.6 0.0021 18.2 0.6 4.4 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 EFC38884.1 - 0.0039 17.0 0.4 0.02 14.7 0.1 2.2 2 0 0 2 2 2 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_11 PF13414.6 EFC38884.1 - 1.2 8.9 8.9 0.49 10.1 0.2 4.2 5 0 0 5 5 5 0 TPR repeat Fis1_TPR_C PF14853.6 EFC38884.1 - 4.2 7.5 8.7 4.5 7.4 0.1 4.1 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat DUF2314 PF10077.9 EFC38885.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2314) Ras PF00071.22 EFC38887.1 - 4.7e-51 172.6 0.1 6e-51 172.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38887.1 - 1.8e-17 63.6 0.0 2.9e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC38887.1 - 1.3e-11 44.2 0.0 1.6e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC38887.1 - 1.1e-05 25.1 0.0 2.3e-05 24.0 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain G-alpha PF00503.20 EFC38887.1 - 0.048 12.8 0.1 3.7 6.6 0.1 2.2 1 1 1 2 2 2 0 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC38887.1 - 0.049 13.7 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC38887.1 - 0.12 12.3 0.4 8.4 6.3 0.4 2.3 1 1 0 2 2 2 0 RsgA GTPase NHL PF01436.21 EFC38888.1 - 5.2e-16 57.8 10.3 2.9e-05 23.9 0.3 5.5 5 0 0 5 5 5 4 NHL repeat PQQ PF01011.21 EFC38888.1 - 3.6e-06 26.6 1.0 0.15 12.0 0.2 3.1 3 0 0 3 3 3 2 PQQ enzyme repeat DUF5128 PF17170.4 EFC38888.1 - 3.4e-05 23.2 1.2 0.0095 15.1 0.1 2.6 2 1 0 2 2 2 2 6-bladed beta-propeller SGL PF08450.12 EFC38888.1 - 0.0001 22.0 0.1 0.27 10.8 0.0 2.6 2 1 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region PQQ_3 PF13570.6 EFC38888.1 - 0.0011 19.4 0.1 0.076 13.5 0.1 2.7 2 0 0 2 2 2 1 PQQ-like domain Arylesterase PF01731.20 EFC38888.1 - 0.0048 17.1 0.0 0.14 12.4 0.0 2.6 2 0 0 2 2 2 1 Arylesterase PQQ_2 PF13360.6 EFC38888.1 - 0.017 14.7 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 PQQ-like domain Lactonase PF10282.9 EFC38888.1 - 0.025 13.9 0.0 1.9 7.6 0.0 2.9 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller His_Phos_1 PF00300.22 EFC38889.1 - 5.3e-42 143.7 0.0 6.5e-42 143.4 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) LRR_6 PF13516.6 EFC38890.1 - 4.4e-22 76.2 10.0 7.9e-05 22.4 0.0 11.2 12 0 0 12 12 12 5 Leucine Rich repeat LRR_8 PF13855.6 EFC38890.1 - 3.4e-18 65.2 27.9 1.4e-05 24.8 2.9 6.2 5 2 1 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 EFC38890.1 - 4.7e-14 52.3 35.0 0.005 17.2 2.5 8.4 2 2 6 9 9 9 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38890.1 - 7.3e-05 22.8 11.1 8.9 7.3 0.1 8.1 10 0 0 10 10 10 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC38890.1 - 0.0013 18.2 9.3 0.26 10.8 0.1 3.9 1 1 3 4 4 4 3 Leucine-rich repeat TypeIII_RM_meth PF12564.8 EFC38890.1 - 0.0038 17.3 2.3 0.56 10.4 0.2 3.3 3 0 0 3 3 3 1 Type III restriction/modification enzyme methylation subunit DUF5347 PF17282.2 EFC38890.1 - 0.085 13.2 0.0 0.54 10.6 0.0 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF5347) Sel1 PF08238.12 EFC38891.1 - 2.7e-21 75.5 1.3 3.9e-07 30.5 0.0 5.4 5 0 0 5 5 5 4 Sel1 repeat TPR_2 PF07719.17 EFC38891.1 - 0.0045 17.0 0.2 1.6 9.1 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38891.1 - 0.011 16.1 0.1 0.99 9.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38891.1 - 0.091 12.7 0.0 5.4 7.0 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC38891.1 - 0.11 13.4 0.0 16 6.6 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38891.1 - 0.12 12.2 0.0 19 5.3 0.0 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat NOA36 PF06524.12 EFC38891.1 - 1.9 7.7 9.1 3.3 7.0 9.1 1.4 1 0 0 1 1 1 0 NOA36 protein TrmO PF01980.16 EFC38892.1 - 2.4e-36 124.5 0.0 5.2e-36 123.4 0.0 1.6 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 EFC38892.1 - 8.8e-06 25.7 1.0 2.4e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 TrmO C-terminal domain DehI PF10778.9 EFC38892.1 - 0.063 13.4 3.6 8.4 6.5 0.1 2.9 3 0 0 3 3 3 0 Halocarboxylic acid dehydrogenase DehI NCBP3 PF10309.9 EFC38892.1 - 0.13 12.1 0.1 0.33 10.9 0.1 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 DDE_Tnp_IS240 PF13610.6 EFC38892.1 - 0.35 11.1 3.1 0.45 10.7 0.7 2.4 2 1 0 2 2 2 0 DDE domain Cwf_Cwc_15 PF04889.12 EFC38892.1 - 3.4 7.3 17.8 8.3 6.1 17.8 1.7 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PP2C PF00481.21 EFC38894.1 - 2.2e-50 171.7 10.0 1.7e-46 158.9 0.9 3.1 2 1 1 3 3 3 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFC38894.1 - 9e-05 22.2 0.0 0.00033 20.4 0.0 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C QueC PF06508.13 EFC38894.1 - 0.15 11.5 1.2 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC SMN PF06003.12 EFC38894.1 - 0.47 9.7 8.6 0.49 9.6 6.7 1.9 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) DTHCT PF08070.11 EFC38894.1 - 2.3 9.0 9.5 0.37 11.5 4.5 2.2 2 0 0 2 2 2 0 DTHCT (NUC029) region UQ_con PF00179.26 EFC38895.1 - 2.4e-22 79.1 0.3 5.4e-22 77.9 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box-like PF12937.7 EFC38895.1 - 6.9e-09 35.5 0.1 1.3e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC38895.1 - 9.4e-07 28.6 0.1 3e-06 27.0 0.1 1.9 1 0 0 1 1 1 1 F-box domain RWD PF05773.22 EFC38895.1 - 0.0019 18.5 0.1 0.0076 16.5 0.1 2.1 1 0 0 1 1 1 1 RWD domain F-box_4 PF15966.5 EFC38895.1 - 0.058 13.3 0.1 0.93 9.4 0.0 2.4 2 0 0 2 2 2 0 F-box EF-hand_6 PF13405.6 EFC38896.1 - 1.4e-11 43.3 24.8 0.1 12.6 0.1 9.7 10 0 0 10 10 10 4 EF-hand domain PRK PF00485.18 EFC38896.1 - 2e-09 37.5 0.1 6.7e-09 35.8 0.0 2.0 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family EF-hand_11 PF08976.11 EFC38896.1 - 1.3e-08 35.7 27.9 0.034 15.0 0.1 8.2 8 0 0 8 8 8 3 EF-hand domain AAA_18 PF13238.6 EFC38896.1 - 0.00053 20.5 0.0 0.0053 17.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain EF-hand_7 PF13499.6 EFC38896.1 - 0.0011 19.4 0.8 0.0011 19.4 0.8 8.8 5 3 5 10 10 10 1 EF-hand domain pair ATP_bind_1 PF03029.17 EFC38896.1 - 0.0024 17.7 0.1 0.0091 15.8 0.0 2.1 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein EF-hand_1 PF00036.32 EFC38896.1 - 0.0032 16.9 22.7 1.7 8.4 0.1 8.3 9 0 0 9 9 8 2 EF hand AAA_22 PF13401.6 EFC38896.1 - 0.0036 17.6 0.0 0.082 13.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC38896.1 - 0.0078 16.6 0.1 0.12 12.8 0.0 2.9 4 0 0 4 4 4 1 AAA ATPase domain FGAR-AT_linker PF18072.1 EFC38896.1 - 0.016 15.8 2.6 18 6.0 0.0 5.1 5 0 0 5 5 5 0 Formylglycinamide ribonucleotide amidotransferase linker domain RST PF12174.8 EFC38896.1 - 0.022 14.7 11.4 2.8 7.9 0.2 6.8 7 2 2 9 9 9 0 RCD1-SRO-TAF4 (RST) plant domain DUF5446 PF17522.2 EFC38896.1 - 5.7 7.2 6.5 8.6 6.6 0.1 4.0 4 0 0 4 4 3 0 Family of unknown function (DUF5446) Helicase_C PF00271.31 EFC38897.1 - 2.8e-05 24.4 0.0 8.4e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC38897.1 - 0.00028 20.7 0.0 0.0065 16.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4116 PF13475.6 EFC38898.1 - 5.7e-38 128.4 22.1 1.3e-09 37.7 0.0 9.0 7 1 3 10 10 10 5 Domain of unknown function (DUF4116) AAA_22 PF13401.6 EFC38899.1 - 0.062 13.6 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 EFC38901.1 - 3.3e-40 132.7 17.8 0.00029 20.6 0.0 10.7 11 0 0 11 11 11 9 Leucine Rich repeat LRR_8 PF13855.6 EFC38901.1 - 3.8e-26 90.6 17.4 8.8e-10 38.2 0.6 4.8 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC38901.1 - 2.2e-22 78.8 20.9 2e-06 28.0 0.1 7.0 3 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38901.1 - 2.3e-13 48.7 6.1 6.6 7.7 0.3 10.0 10 0 0 10 10 10 3 Leucine Rich Repeat F-box PF00646.33 EFC38901.1 - 0.00055 19.7 3.1 0.0016 18.2 3.2 1.8 1 1 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC38901.1 - 0.004 17.0 0.7 0.01 15.7 0.2 1.9 1 1 0 1 1 1 1 F-box-like Beta_helix PF13229.6 EFC38901.1 - 9.9 6.0 21.6 3.2 7.6 1.3 2.9 1 1 0 2 2 2 0 Right handed beta helix region Pep_deformylase PF01327.21 EFC38902.1 - 9.5e-27 93.6 0.0 7.9e-26 90.6 0.0 2.1 1 1 0 1 1 1 1 Polypeptide deformylase UCH PF00443.29 EFC38903.1 - 9.3e-45 153.1 2.0 9.3e-45 153.1 2.0 3.0 4 1 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC38903.1 - 1.6e-17 64.1 0.2 1.6e-17 64.1 0.2 3.4 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase DUF5106 PF17127.4 EFC38903.1 - 6.1 7.1 9.3 7.3 6.8 0.1 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5106) INO80_Ies4 PF08193.11 EFC38904.1 - 0.58 10.1 4.5 1 9.3 4.5 1.3 1 0 0 1 1 1 0 INO80 complex subunit Ies4 Ipi1_N PF12333.8 EFC38904.1 - 2.3 8.9 5.8 0.43 11.2 0.2 2.8 3 1 1 4 4 4 0 Rix1 complex component involved in 60S ribosome maturation Methyltrn_RNA_2 PF04013.12 EFC38905.1 - 0.15 11.7 2.3 0.26 11.0 2.3 1.3 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase YPEB PF14620.6 EFC38905.1 - 0.2 10.9 6.1 0.35 10.2 6.2 1.3 1 1 0 1 1 1 0 YpeB sporulation RSRP PF17069.5 EFC38905.1 - 0.65 9.5 4.5 8.5 5.9 3.0 2.1 2 0 0 2 2 2 0 Arginine/Serine-Rich protein 1 MAS20 PF02064.15 EFC38905.1 - 5.3 7.1 8.0 12 6.0 8.0 1.6 1 0 0 1 1 1 0 MAS20 protein import receptor Tubulin PF00091.25 EFC38906.1 - 3.2e-63 213.5 0.0 4.6e-63 213.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC38906.1 - 1.1e-24 87.0 0.1 2.3e-24 86.0 0.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 EFC38906.1 - 0.001 18.3 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 EFC38906.1 - 0.0035 17.6 0.1 0.054 13.8 0.0 2.5 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFC38906.1 - 0.018 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain TnpV PF14198.6 EFC38906.1 - 0.13 12.2 1.4 0.47 10.4 0.0 2.2 2 0 0 2 2 2 0 Transposon-encoded protein TnpV LRR_4 PF12799.7 EFC38907.1 - 5.4e-10 39.4 43.0 0.024 15.1 3.3 10.0 6 3 5 11 11 11 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC38907.1 - 5.6e-05 22.9 20.1 0.34 11.1 0.0 9.5 11 0 0 11 11 11 2 Leucine Rich repeat LRR_8 PF13855.6 EFC38907.1 - 0.0024 17.6 25.4 0.017 14.8 0.7 7.9 6 2 1 7 7 7 2 Leucine rich repeat CLP1_P PF16575.5 EFC38908.1 - 4.2e-19 69.1 0.1 8.5e-19 68.1 0.1 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Pox_Ag35 PF03286.14 EFC38908.1 - 5.3 6.8 11.7 10 5.9 11.7 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Hamartin PF04388.12 EFC38909.1 - 0.42 9.2 46.7 0.7 8.5 46.7 1.3 1 0 0 1 1 1 0 Hamartin protein Torus PF16131.5 EFC38910.1 - 7.5e-06 26.6 1.6 7.5e-06 26.6 1.6 2.1 2 0 0 2 2 2 1 Torus domain Med26 PF08711.11 EFC38910.1 - 0.00031 20.7 0.4 0.00096 19.1 0.4 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain zf_CCCH_4 PF18345.1 EFC38910.1 - 0.00048 20.1 4.9 0.00088 19.2 4.9 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFC38910.1 - 0.001 18.8 3.1 0.0018 18.0 3.1 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 EFC38910.1 - 0.0055 16.6 2.9 0.01 15.7 2.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PBP1_TM PF14812.6 EFC38910.1 - 0.012 16.0 1.2 0.029 14.7 1.2 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LMBR1 PF04791.16 EFC38910.1 - 0.18 10.7 5.8 0.28 10.0 5.8 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein QIL1 PF15884.5 EFC38910.1 - 0.42 11.2 5.0 1.6 9.4 0.2 3.2 3 0 0 3 3 3 0 MICOS complex subunit MIC13, QIL1 zf-CCCH_2 PF14608.6 EFC38910.1 - 1.3 9.7 4.3 2.3 8.8 4.3 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF4661 PF15576.6 EFC38910.1 - 6 6.7 5.9 11 5.8 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Rhodanese PF00581.20 EFC38911.1 - 9.6e-16 58.2 0.1 3.8e-15 56.3 0.0 2.1 2 0 0 2 2 2 1 Rhodanese-like domain IQ PF00612.27 EFC38912.1 - 0.0055 16.4 0.3 0.0055 16.4 0.3 4.0 4 0 0 4 4 4 2 IQ calmodulin-binding motif G-alpha PF00503.20 EFC38913.1 - 1.8e-08 33.9 4.9 3.6e-06 26.4 4.9 2.0 1 1 0 1 1 1 1 G-protein alpha subunit ATPase_2 PF01637.18 EFC38913.1 - 1.6e-05 25.0 0.2 1.9e-05 24.7 0.2 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EFC38913.1 - 0.011 15.7 0.1 0.027 14.4 0.1 1.7 1 0 0 1 1 1 0 RsgA GTPase DUF815 PF05673.13 EFC38913.1 - 0.043 13.0 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 EFC38913.1 - 0.2 12.1 0.8 0.44 11.1 0.8 1.6 1 1 0 1 1 1 0 ABC transporter RNA_pol_Rpb1_7 PF04990.12 EFC38915.1 - 0.083 12.9 0.6 0.13 12.2 0.6 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 SVA PF05326.11 EFC38915.1 - 0.46 10.5 7.3 0.36 10.8 4.6 1.9 1 1 1 2 2 2 0 Seminal vesicle autoantigen (SVA) Pkinase PF00069.25 EFC38916.1 - 1.3e-23 83.7 5.7 2.1e-23 83.1 5.7 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38916.1 - 1.4e-11 44.2 0.5 2.4e-11 43.4 0.5 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC38916.1 - 0.00083 18.2 0.0 0.0017 17.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DUF3986 PF13143.6 EFC38916.1 - 0.049 14.6 4.7 8.4 7.4 1.8 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3986) DUF4116 PF13475.6 EFC38917.1 - 1.4e-54 181.6 7.4 3.3e-16 58.7 0.0 6.4 5 1 1 7 7 7 4 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC38917.1 - 5.4e-24 85.0 3.1 5.4e-24 85.0 3.1 3.2 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38917.1 - 3.6e-10 39.6 0.2 1.6e-08 34.1 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase Csm1_N PF18504.1 EFC38917.1 - 0.27 11.6 8.0 0.24 11.7 4.7 2.8 2 0 0 2 2 2 0 Csm1 N-terminal domain APC_N_CC PF16689.5 EFC38917.1 - 0.52 10.4 8.3 0.42 10.7 4.8 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Rab_bind PF16704.5 EFC38917.1 - 1.1 9.3 6.6 0.34 11.0 2.6 2.3 2 0 0 2 2 2 0 Rab binding domain YabA PF06156.13 EFC38917.1 - 4.8 7.9 8.9 17 6.1 5.0 3.0 2 0 0 2 2 2 0 Initiation control protein YabA DUF5638 PF18688.1 EFC38917.1 - 7.2 7.0 12.4 0.3 11.4 2.5 3.9 4 0 0 4 4 4 0 Family of unknown function (DUF5638) ABC_tran PF00005.27 EFC38918.1 - 1.5e-49 168.0 2.6 3.4e-29 102.1 0.7 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFC38918.1 - 1.1e-41 143.3 40.7 3.7e-27 95.7 18.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region RsgA_GTPase PF03193.16 EFC38918.1 - 5.8e-06 26.3 1.0 0.038 13.9 0.1 2.8 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 EFC38918.1 - 2.3e-05 23.9 12.2 0.098 12.1 4.5 4.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFC38918.1 - 6.1e-05 23.1 0.0 0.086 12.9 0.0 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_16 PF13191.6 EFC38918.1 - 8e-05 23.1 0.2 0.0052 17.2 0.1 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_7 PF12775.7 EFC38918.1 - 0.00043 19.8 0.1 0.048 13.2 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFC38918.1 - 0.00045 20.5 0.2 0.029 14.6 0.3 3.3 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFC38918.1 - 0.0014 18.3 0.7 0.055 13.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain Roc PF08477.13 EFC38918.1 - 0.0063 16.7 0.0 0.2 11.9 0.0 3.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase DUF87 PF01935.17 EFC38918.1 - 0.012 15.7 4.2 0.075 13.1 0.1 3.0 2 0 0 2 2 2 0 Helicase HerA, central domain RNA_helicase PF00910.22 EFC38918.1 - 0.029 14.8 0.1 2.1 8.8 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Viral_helicase1 PF01443.18 EFC38918.1 - 0.046 13.5 0.0 0.76 9.5 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.18 EFC38918.1 - 0.05 12.9 0.0 0.17 11.2 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_21 PF13304.6 EFC38918.1 - 0.05 13.4 6.2 2.5 7.9 0.0 3.9 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 EFC38918.1 - 0.099 12.4 1.2 2.6 7.7 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein AAA_24 PF13479.6 EFC38918.1 - 0.16 11.6 0.6 3.1 7.5 0.2 2.6 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EFC38918.1 - 0.19 11.6 0.5 3.2 7.7 0.0 3.1 3 0 0 3 3 3 0 NACHT domain TrwB_AAD_bind PF10412.9 EFC38918.1 - 0.65 8.8 3.7 0.3 10.0 0.1 2.3 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 EFC38918.1 - 0.95 9.5 11.9 2 8.4 0.2 3.9 3 2 0 3 3 3 0 Dynamin family Ras PF00071.22 EFC38919.1 - 1.1e-22 80.4 0.1 1.6e-22 79.8 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38919.1 - 1.2e-10 41.7 0.0 2.3e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC38919.1 - 1.2e-05 25.0 0.0 0.049 13.2 0.1 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC38919.1 - 9.8e-05 22.4 0.0 0.00019 21.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EFC38919.1 - 0.00023 21.4 0.1 0.19 11.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 EFC38919.1 - 0.00052 20.0 0.0 0.48 10.3 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EFC38919.1 - 0.012 15.6 0.1 0.03 14.3 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 EFC38919.1 - 0.018 14.4 0.0 0.034 13.5 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 EFC38919.1 - 0.074 12.8 0.0 5 6.8 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 EFC38919.1 - 0.11 12.3 0.1 1.3 8.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EFC38919.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein cobW PF02492.19 EFC38919.1 - 0.15 11.7 0.1 12 5.5 0.0 2.3 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EFC38919.1 - 0.24 11.9 3.9 0.41 11.1 0.1 2.6 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFC38922.1 - 0.0047 16.9 0.1 0.029 14.3 0.1 2.1 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFC38922.1 - 0.0064 16.8 0.0 0.44 10.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC38922.1 - 0.0072 16.7 0.0 0.016 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RGS PF00615.19 EFC38923.1 - 2.3e-21 76.3 5.2 2.3e-21 76.3 5.2 2.3 3 0 0 3 3 3 1 Regulator of G protein signaling domain CybS PF05328.12 EFC38923.1 - 0.14 11.8 0.1 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 CybS, succinate dehydrogenase cytochrome B small subunit HSP70 PF00012.20 EFC38925.1 - 7.2e-261 866.6 8.7 8.3e-261 866.4 8.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC38925.1 - 1.8e-18 66.5 5.0 3.9e-17 62.1 0.0 3.0 3 0 0 3 3 3 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC38925.1 - 0.0048 16.2 0.1 0.031 13.5 0.1 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase FtsA PF14450.6 EFC38925.1 - 0.033 14.6 0.7 12 6.4 0.0 3.4 3 1 0 3 3 3 0 Cell division protein FtsA DDR PF08841.10 EFC38925.1 - 0.034 13.1 1.3 0.46 9.4 0.1 2.6 3 0 0 3 3 3 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 EFC38925.1 - 0.068 12.6 0.0 4 6.8 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family EAP30 PF04157.16 EFC38925.1 - 0.95 8.7 5.8 3.8 6.7 2.5 2.4 2 1 0 2 2 2 0 EAP30/Vps36 family Cys_rich_FGFR PF00839.17 EFC38925.1 - 1.5 9.1 6.0 14 5.9 1.6 2.8 2 0 0 2 2 2 0 Cysteine rich repeat UPF0242 PF06785.11 EFC38925.1 - 3.4 7.7 7.5 6.7 6.8 7.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Erp_C PF06780.11 EFC38925.1 - 4.8 7.2 12.1 2.4 8.2 9.0 2.1 3 0 0 3 3 3 0 Erp protein C-terminus RsgA_GTPase PF03193.16 EFC38926.1 - 0.00065 19.7 0.0 0.93 9.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC38926.1 - 0.045 13.8 0.0 0.075 13.1 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Reoviridae_Vp9 PF08978.10 EFC38926.1 - 0.074 12.2 0.0 0.78 8.9 0.0 2.1 2 0 0 2 2 2 0 Reoviridae VP9 Nup192 PF11894.8 EFC38927.1 - 5.8e-107 358.6 54.1 4.8e-74 249.5 31.4 2.6 1 1 1 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 Pkinase PF00069.25 EFC38927.1 - 2.9e-47 161.3 0.4 7.1e-47 160.0 0.4 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38927.1 - 4.5e-36 124.5 1.7 2.5e-34 118.7 1.7 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC38927.1 - 4.7e-22 76.8 6.8 0.0029 17.5 0.0 9.5 10 0 0 10 10 10 5 NHL repeat SGL PF08450.12 EFC38927.1 - 4.2e-06 26.5 0.4 2 7.9 0.0 4.7 3 2 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC38927.1 - 2.5e-05 24.6 29.8 0.016 15.6 11.2 2.7 2 0 0 2 2 2 2 EGF-like domain Str_synth PF03088.16 EFC38927.1 - 0.016 15.3 0.1 0.4 10.8 0.0 3.6 3 0 0 3 3 3 0 Strictosidine synthase EGF PF00008.27 EFC38927.1 - 4.7 7.6 17.4 0.02 15.2 3.2 2.9 2 0 0 2 2 2 0 EGF-like domain FtsX PF02687.21 EFC38928.1 - 0.3 11.6 7.5 6.5 7.3 3.9 2.6 2 0 0 2 2 2 0 FtsX-like permease family DUF3487 PF11990.8 EFC38928.1 - 3 7.7 5.0 6 6.8 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) LpxI_N PF17930.1 EFC38929.1 - 0.18 11.7 0.0 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain LRR_4 PF12799.7 EFC38930.1 - 5.1e-15 55.3 42.9 1.8e-05 25.0 0.6 9.9 11 1 0 11 11 11 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC38930.1 - 7.9e-12 44.2 29.4 0.002 18.0 0.0 11.0 12 0 0 12 12 12 4 Leucine Rich repeat F-box-like PF12937.7 EFC38930.1 - 0.00043 20.1 0.0 0.0014 18.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 EFC38930.1 - 0.0014 18.4 27.7 0.063 13.0 1.4 7.7 7 2 1 8 8 8 3 Leucine rich repeat LRR_1 PF00560.33 EFC38930.1 - 0.0018 18.5 18.5 6.4 7.7 0.1 8.9 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC38930.1 - 0.09 12.3 10.8 5.7 6.4 0.1 4.2 3 1 1 4 4 4 0 Leucine-rich repeat DSPc PF00782.20 EFC38931.1 - 1.5e-30 105.7 0.1 1.3e-28 99.5 0.1 2.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC38931.1 - 3.4e-06 26.8 0.1 3.2e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFC38931.1 - 0.022 15.0 0.0 0.039 14.2 0.0 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain UCH PF00443.29 EFC38932.1 - 0.044 13.3 0.3 0.048 13.1 0.3 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Staphostatin_B PF09023.10 EFC38932.1 - 0.061 13.4 1.0 0.18 11.9 0.6 2.1 2 0 0 2 2 2 0 Staphostatin B LptF_LptG PF03739.14 EFC38932.1 - 0.18 10.6 0.2 0.2 10.4 0.2 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG OSCP PF00213.18 EFC38934.1 - 4.3e-08 33.5 0.0 1.1e-07 32.1 0.0 1.8 2 1 0 2 2 2 1 ATP synthase delta (OSCP) subunit CTP_synth_N PF06418.14 EFC38935.1 - 2.3e-119 397.6 0.2 3.2e-119 397.1 0.2 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 EFC38935.1 - 3.7e-49 167.1 0.1 7.4e-49 166.1 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFC38935.1 - 4.1e-05 23.4 0.4 0.0039 17.0 0.2 2.7 1 1 1 2 2 2 1 Peptidase C26 PRMT5 PF05185.16 EFC38935.1 - 0.0072 16.2 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase CbiA PF01656.23 EFC38935.1 - 0.074 13.1 0.0 0.2 11.7 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Act-Frag_cataly PF09192.10 EFC38936.1 - 2.9e-34 118.7 5.3 2e-33 116.0 5.3 2.0 1 1 0 1 1 1 1 Actin-fragmin kinase, catalytic PI3_PI4_kinase PF00454.27 EFC38936.1 - 0.0039 17.0 0.3 0.0073 16.1 0.3 1.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF5595 PF18077.1 EFC38937.1 - 0.00044 20.3 0.5 0.39 10.8 0.2 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF5595) GTP_EFTU PF00009.27 EFC38938.1 - 1.7e-10 40.8 0.0 1.6e-09 37.6 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC38938.1 - 2.1e-08 34.4 0.0 5.2e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC38938.1 - 4.1e-08 33.5 0.2 9.1e-08 32.4 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFC38938.1 - 0.00033 20.5 1.8 0.0007 19.5 1.8 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 4 RsgA_GTPase PF03193.16 EFC38938.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC38938.1 - 0.0056 16.4 0.1 0.014 15.1 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 EFC38938.1 - 0.0059 17.1 0.0 0.012 16.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 EFC38938.1 - 0.029 14.5 0.1 0.11 12.5 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF3198 PF11433.8 EFC38938.1 - 0.083 12.8 0.4 12 5.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3198) AAA_22 PF13401.6 EFC38938.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFC38938.1 - 0.13 12.0 0.6 6.7 6.5 0.2 3.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 EFC38938.1 - 0.15 12.0 0.9 0.29 11.1 0.9 1.7 1 1 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 EFC38938.1 - 0.17 12.3 0.0 0.29 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Flavodoxin_2 PF02525.17 EFC38939.1 - 1.4e-38 132.7 0.1 1.6e-38 132.4 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EFC38939.1 - 0.00016 21.4 0.0 0.00023 21.0 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase FBA_2 PF07735.17 EFC38939.1 - 0.12 12.6 3.8 21 5.3 2.0 3.8 3 1 1 4 4 4 0 F-box associated CBFD_NFYB_HMF PF00808.23 EFC38943.1 - 4.4e-22 78.1 0.4 8.2e-22 77.3 0.4 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFC38943.1 - 3.1e-06 27.6 0.1 3.1e-06 27.6 0.1 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFC38943.1 - 0.0052 16.9 0.0 0.0079 16.3 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAN_3 PF08277.12 EFC38943.1 - 0.012 15.4 1.9 0.012 15.4 1.9 1.9 2 1 0 2 2 2 0 PAN-like domain DUF3362 PF11842.8 EFC38943.1 - 0.035 14.4 0.7 0.07 13.5 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) Anticodon_1 PF08264.13 EFC38944.1 - 1.1e-07 31.9 1.0 3.5e-07 30.3 0.5 2.1 1 1 1 2 2 2 1 Anticodon-binding domain of tRNA LRR_6 PF13516.6 EFC38945.1 - 2.5e-23 80.1 35.1 0.018 15.0 1.1 12.8 13 0 0 13 13 13 8 Leucine Rich repeat LRR_8 PF13855.6 EFC38945.1 - 1.2e-15 57.0 39.4 0.00036 20.2 0.3 5.8 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC38945.1 - 1.7e-14 53.7 53.9 0.059 13.8 0.2 8.7 1 1 8 10 10 10 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC38945.1 - 2.7e-05 23.7 13.2 0.16 11.5 0.0 4.3 1 1 4 5 5 5 2 Leucine-rich repeat Rtf2 PF04641.12 EFC38945.1 - 0.0024 17.3 2.2 0.12 11.8 0.4 2.4 1 1 1 2 2 2 2 Rtf2 RING-finger F-box-like PF12937.7 EFC38945.1 - 0.0052 16.7 0.8 0.011 15.7 0.8 1.4 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC38945.1 - 0.14 12.8 26.0 16 6.5 0.1 9.6 10 2 0 10 10 10 0 Leucine Rich Repeat C2 PF00168.30 EFC38946.1 - 5e-15 55.6 0.2 1.4e-14 54.2 0.2 1.7 1 0 0 1 1 1 1 C2 domain LRR_6 PF13516.6 EFC38947.1 - 4.9e-26 88.5 5.1 0.00079 19.3 0.1 8.2 8 0 0 8 8 8 7 Leucine Rich repeat LRR_8 PF13855.6 EFC38947.1 - 2.6e-15 55.9 6.5 5.1e-07 29.3 0.6 4.2 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC38947.1 - 6.2e-15 55.1 7.4 0.0017 18.7 1.0 4.9 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC38947.1 - 0.00021 21.4 4.5 23 6.1 0.1 6.3 7 1 0 7 7 7 0 Leucine Rich Repeat FTH PF01827.27 EFC38947.1 - 0.00064 19.5 0.1 0.0061 16.3 0.0 2.1 1 1 1 2 2 2 1 FTH domain Phage_CI_C PF16452.5 EFC38947.1 - 0.0007 19.8 0.3 0.81 10.0 0.1 3.5 1 1 3 4 4 4 1 Bacteriophage CI repressor C-terminal domain RecO_N_2 PF13114.6 EFC38947.1 - 0.0014 18.2 1.0 0.47 10.2 0.0 3.2 4 0 0 4 4 4 2 RecO N terminal ApoB100_C PF12491.8 EFC38947.1 - 0.06 13.3 2.3 25 4.9 0.0 4.3 3 1 1 4 4 4 0 Apolipoprotein B100 C terminal Dynamin_N PF00350.23 EFC38948.1 - 1.9e-22 80.1 5.5 3.9e-10 40.0 0.0 4.1 3 1 1 4 4 4 2 Dynamin family MMR_HSR1 PF01926.23 EFC38948.1 - 1.9e-13 50.5 0.6 6.9e-13 48.7 0.0 2.4 3 0 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC38948.1 - 1.1e-08 34.9 0.7 5.4e-08 32.6 0.2 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC38948.1 - 1.9e-06 27.9 0.5 0.05 13.5 0.1 3.1 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EFC38948.1 - 0.00074 19.1 0.0 0.85 9.1 0.0 2.6 2 0 0 2 2 2 2 Ferrous iron transport protein B Roc PF08477.13 EFC38948.1 - 0.0014 18.8 0.0 0.0072 16.5 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFC38948.1 - 0.0018 18.0 0.0 0.0083 15.9 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Phage_HK97_TLTM PF06120.11 EFC38948.1 - 0.0034 16.6 0.3 0.0034 16.6 0.3 2.7 3 0 0 3 3 3 1 Tail length tape measure protein YtxH PF12732.7 EFC38948.1 - 0.025 15.1 0.4 1.4 9.5 0.1 3.3 2 1 0 2 2 2 0 YtxH-like protein Retinin_C PF04527.12 EFC38948.1 - 0.088 13.1 2.1 0.19 12.0 2.1 1.5 1 0 0 1 1 1 0 Drosophila Retinin like protein Tweety PF04906.13 EFC38948.1 - 0.29 9.8 1.6 3.9 6.0 0.0 2.2 2 0 0 2 2 2 0 Tweety Occludin_ELL PF07303.13 EFC38948.1 - 1.7 9.4 17.2 5.9 7.7 2.1 4.2 3 1 1 4 4 4 0 Occludin homology domain zf-TFIIIC PF12660.7 EFC38949.1 - 0.0035 17.3 0.3 0.012 15.6 0.1 1.7 1 1 1 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex AT_hook PF02178.19 EFC38949.1 - 0.0086 15.8 3.7 0.015 15.1 3.7 1.4 1 0 0 1 1 1 1 AT hook motif p450 PF00067.22 EFC38950.1 - 5.2e-73 246.4 8.5 2.6e-70 237.5 0.1 3.1 3 1 1 4 4 4 2 Cytochrome P450 TPR_2 PF07719.17 EFC38950.1 - 2.7e-05 23.9 0.2 0.0013 18.7 0.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Sel1 PF08238.12 EFC38950.1 - 0.00048 20.7 0.1 0.0032 18.1 0.0 2.5 3 0 0 3 3 3 1 Sel1 repeat TPR_6 PF13174.6 EFC38950.1 - 0.00058 20.3 0.4 8.5 7.2 0.1 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TipAS PF07739.13 EFC38950.1 - 0.019 15.5 2.2 13 6.4 0.0 3.7 4 0 0 4 4 4 0 TipAS antibiotic-recognition domain TPR_7 PF13176.6 EFC38950.1 - 0.028 14.4 0.0 0.24 11.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC38950.1 - 0.038 13.8 0.2 0.97 9.4 0.3 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38950.1 - 0.071 13.4 0.8 0.32 11.3 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat MCR_C PF04609.12 EFC38950.1 - 0.2 10.7 0.5 0.52 9.3 0.5 1.6 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C DUF4363 PF14276.6 EFC38950.1 - 0.39 10.8 5.4 0.19 11.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) SRP1_TIP1 PF00660.17 EFC38951.1 - 0.061 13.4 0.4 0.33 11.0 0.1 2.3 2 0 0 2 2 2 0 Seripauperin and TIP1 family ADH_zinc_N PF00107.26 EFC38953.1 - 3.7e-19 69.0 0.0 6.7e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFC38953.1 - 4.6e-17 61.9 0.0 1.1e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 EFC38953.1 - 2.5e-09 38.3 0.0 7.2e-09 36.8 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase SGTA_dimer PF16546.5 EFC38954.1 - 0.058 13.2 0.2 0.34 10.7 0.0 2.4 3 0 0 3 3 3 0 Homodimerisation domain of SGTA Ras PF00071.22 EFC38955.1 - 4.9e-32 110.8 0.0 8e-32 110.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC38955.1 - 3.5e-18 65.9 0.0 7.1e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC38955.1 - 0.00017 21.1 0.0 0.00025 20.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC38955.1 - 0.0018 17.7 0.0 0.0046 16.4 0.0 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFC38955.1 - 0.0057 16.6 0.0 0.024 14.5 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase Tfb2_C PF18307.1 EFC38955.1 - 0.021 15.2 0.0 0.32 11.5 0.0 2.4 2 0 0 2 2 2 0 Transcription factor Tfb2 (p52) C-terminal domain DUF4939 PF16297.5 EFC38956.1 - 0.027 14.3 0.1 0.054 13.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4939) HSP70 PF00012.20 EFC38957.1 - 5.7e-261 867.0 8.6 6.5e-261 866.8 8.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC38957.1 - 1.8e-18 66.5 5.0 3.9e-17 62.1 0.0 3.0 3 0 0 3 3 3 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC38957.1 - 0.0047 16.2 0.1 0.031 13.5 0.1 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase EAP30 PF04157.16 EFC38957.1 - 0.025 13.8 2.2 0.25 10.6 0.5 2.4 2 0 0 2 2 2 0 EAP30/Vps36 family FtsA PF14450.6 EFC38957.1 - 0.031 14.7 0.6 12 6.4 0.0 3.4 3 1 0 3 3 3 0 Cell division protein FtsA DDR PF08841.10 EFC38957.1 - 0.033 13.2 1.5 0.46 9.4 0.1 2.7 3 0 0 3 3 3 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 EFC38957.1 - 0.069 12.6 0.0 4 6.8 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Cys_rich_FGFR PF00839.17 EFC38957.1 - 1.1 9.5 6.1 14 5.9 1.6 2.8 2 0 0 2 2 2 0 Cysteine rich repeat AT_hook PF02178.19 EFC38958.1 - 0.0055 16.4 3.9 0.0096 15.7 3.9 1.4 1 0 0 1 1 1 1 AT hook motif RGS PF00615.19 EFC38959.1 - 9.9e-06 25.8 4.9 2.1e-05 24.8 4.9 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain adh_short PF00106.25 EFC38962.1 - 2e-16 60.1 0.0 9.9e-15 54.5 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC38962.1 - 1.3e-11 44.5 0.0 2.3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC38962.1 - 2.1e-05 24.5 0.0 5.3e-05 23.2 0.0 1.7 1 1 1 2 2 2 1 KR domain PAE PF03283.13 EFC38962.1 - 0.0024 17.0 0.0 0.0034 16.6 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase BTB_2 PF02214.22 EFC38963.1 - 4.3e-18 65.4 3.3 2.5e-09 37.4 0.1 4.6 2 1 0 2 2 2 2 BTB/POZ domain G-patch PF01585.23 EFC38963.1 - 8.8e-11 41.5 0.6 1.8e-10 40.5 0.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFC38963.1 - 0.0049 16.9 0.1 0.019 15.0 0.1 2.1 1 0 0 1 1 1 1 G-patch domain NT-C2 PF10358.9 EFC38964.1 - 5.4e-11 42.4 4.6 5.4e-11 42.4 4.6 2.2 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins DIL PF01843.19 EFC38964.1 - 2.6e-06 27.7 0.2 2.6e-06 27.7 0.2 2.7 2 0 0 2 2 2 1 DIL domain Tropomyosin PF00261.20 EFC38964.1 - 0.0005 19.5 56.4 0.0005 19.5 56.4 2.3 3 0 0 3 3 3 1 Tropomyosin DUF4201 PF13870.6 EFC38964.1 - 0.0084 15.9 16.7 0.0084 15.9 16.7 4.3 3 1 0 3 3 3 2 Domain of unknown function (DUF4201) TPR_1 PF00515.28 EFC38965.1 - 3.2e-24 83.7 14.1 1.3e-07 31.1 0.0 7.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38965.1 - 3.2e-22 76.8 10.5 8.6e-05 22.4 0.0 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38965.1 - 2.9e-13 49.2 11.4 0.056 13.8 0.0 6.7 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFC38965.1 - 5.6e-11 42.9 0.0 0.017 15.8 0.0 4.4 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38965.1 - 1e-10 41.8 8.7 0.00016 21.9 0.6 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC38965.1 - 2e-10 40.7 0.1 0.0071 16.5 0.0 3.9 2 1 1 4 4 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38965.1 - 4e-08 33.4 4.1 0.041 14.5 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC38965.1 - 1.2e-07 32.1 0.2 0.023 15.2 0.0 3.9 3 1 0 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38965.1 - 1.4e-07 31.2 12.6 0.061 13.6 0.0 6.3 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC38965.1 - 2.3e-07 30.4 7.8 0.0019 17.8 0.3 5.3 1 1 4 5 5 5 2 TPR repeat TPR_14 PF13428.6 EFC38965.1 - 3.6e-05 24.2 0.0 1.1 10.2 0.0 3.6 3 1 0 3 3 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC38965.1 - 9.9e-05 22.5 9.9 0.00031 20.9 3.5 3.2 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFC38965.1 - 0.00023 20.9 3.1 1.9 8.7 0.0 5.0 4 1 0 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC38965.1 - 0.019 15.0 5.7 6.9 6.8 0.1 4.8 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Presenilin PF01080.17 EFC38965.1 - 2.4 6.8 12.2 3.8 6.2 12.2 1.3 1 0 0 1 1 1 0 Presenilin TPR_10 PF13374.6 EFC38965.1 - 3 7.8 4.7 59 3.7 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat VWD PF00094.25 EFC38966.1 - 0.0001 22.6 0.1 0.00026 21.3 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type D domain DUF4979 PF16351.5 EFC38966.1 - 0.059 13.6 0.2 0.1 12.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4979) DUF2383 PF09537.10 EFC38966.1 - 2.3 8.6 14.1 0.27 11.6 1.7 3.3 2 2 0 2 2 2 0 Domain of unknown function (DUF2383) AAA_2 PF07724.14 EFC38967.1 - 6.8e-36 124.0 4.6 2.4e-30 105.9 0.0 3.3 4 0 0 4 4 4 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFC38967.1 - 2.2e-13 50.7 0.0 3.9e-06 27.3 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFC38967.1 - 6.4e-06 26.2 2.4 0.00021 21.3 0.0 4.0 4 1 0 4 4 4 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFC38967.1 - 0.00031 20.2 0.2 0.0038 16.6 0.0 2.5 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI MCM PF00493.23 EFC38967.1 - 0.0016 17.6 0.2 0.07 12.2 0.0 2.6 2 0 0 2 2 2 1 MCM P-loop domain Zeta_toxin PF06414.12 EFC38967.1 - 0.004 16.5 0.0 0.0089 15.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin ClpB_D2-small PF10431.9 EFC38967.1 - 0.004 17.2 0.0 0.018 15.1 0.0 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_22 PF13401.6 EFC38967.1 - 0.0094 16.2 0.0 0.053 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 EFC38967.1 - 0.025 14.3 0.0 0.085 12.6 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EFC38967.1 - 0.027 15.0 0.1 0.19 12.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC38967.1 - 0.042 14.2 0.0 0.19 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 EFC38967.1 - 0.056 13.6 0.0 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFC38967.1 - 0.063 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFC38967.1 - 0.063 13.0 0.0 0.46 10.2 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFC38967.1 - 0.077 13.5 0.0 0.077 13.5 0.0 2.3 2 1 0 2 2 1 0 ABC transporter Hydrolase_3 PF08282.12 EFC38967.1 - 1.9 8.1 9.7 16 5.1 9.6 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase RGS PF00615.19 EFC38968.1 - 2.2e-07 31.2 5.5 4.2e-07 30.3 5.5 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Sirohm_synth_C PF14823.6 EFC38968.1 - 0.065 12.9 0.5 0.18 11.5 0.2 1.9 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal REJ PF02010.15 EFC38970.1 - 3e-47 161.4 17.6 3e-47 161.4 17.6 2.9 2 1 1 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC38970.1 - 2.1e-20 72.7 313.8 0.0001 22.6 8.8 21.4 19 2 0 19 19 19 14 EGF-like domain Com_YlbF PF06133.11 EFC38971.1 - 0.027 15.1 5.0 0.43 11.2 1.7 2.5 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA TPR_1 PF00515.28 EFC38971.1 - 0.59 10.1 7.4 5.9 6.9 0.3 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat RRP7 PF12923.7 EFC38971.1 - 3.2 7.9 6.4 10 6.3 2.1 2.4 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF3896 PF13035.6 EFC38971.1 - 4.5 7.5 6.7 28 4.9 0.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) RGS PF00615.19 EFC38972.1 - 1.4e-06 28.5 4.7 2.9e-06 27.6 4.7 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain C12orf66_like PF09404.10 EFC38972.1 - 0.052 12.4 0.4 0.083 11.7 0.4 1.2 1 0 0 1 1 1 0 KICSTOR complex C12orf66 like Form_Nir_trans PF01226.17 EFC38974.1 - 4e-07 29.6 1.1 5.1e-07 29.3 1.1 1.2 1 0 0 1 1 1 1 Formate/nitrite transporter EIF4E-T PF10477.9 EFC38974.1 - 2.1 7.0 14.7 2.7 6.7 14.7 1.0 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E TMEM43 PF07787.12 EFC38974.1 - 2.2 7.6 9.1 3.4 7.0 9.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 Ald_Xan_dh_C2 PF02738.18 EFC38975.1 - 2.8e-25 88.8 0.0 3.9e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase Ald_Xan_dh_C PF01315.22 EFC38975.1 - 5.7e-21 74.9 0.0 1e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain FAD_binding_5 PF00941.21 EFC38975.1 - 1.7e-20 73.4 0.0 1.2e-19 70.7 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 EFC38975.1 - 4.9e-18 65.2 0.0 1.2e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 EFC38975.1 - 4e-08 33.2 0.0 7.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 [2Fe-2S] binding domain DUF3481 PF11980.8 EFC38975.1 - 0.32 10.7 5.7 2.6 7.8 0.3 3.4 3 0 0 3 3 3 0 C-terminal domain of neuropilin glycoprotein Lipase_3 PF01764.25 EFC38977.1 - 1.4e-18 67.1 0.0 3.3e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) EGF_2 PF07974.13 EFC38977.1 - 5.2e-05 23.5 19.9 0.00026 21.3 5.2 11.6 12 0 0 12 12 12 3 EGF-like domain DUF2974 PF11187.8 EFC38977.1 - 0.00078 19.1 0.4 0.0038 16.8 0.4 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Y_Y_Y PF07495.13 EFC38977.1 - 0.03 14.3 3.6 2.8 8.0 0.2 3.5 3 0 0 3 3 3 0 Y_Y_Y domain DUF4572 PF15139.6 EFC38977.1 - 0.13 12.1 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4572) DUF2306 PF10067.9 EFC38978.1 - 1.4e-22 80.5 7.7 1.4e-22 80.5 7.7 2.3 2 1 0 2 2 2 1 Predicted membrane protein (DUF2306) Metallophos PF00149.28 EFC38980.1 - 1.8e-13 51.5 0.7 3.1e-13 50.7 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC38980.1 - 1.1e-10 41.9 0.1 4.1e-10 40.1 0.1 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF4116 PF13475.6 EFC38981.1 - 1.6e-106 347.9 20.1 6.2e-19 67.5 0.0 10.4 8 2 2 11 11 11 9 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC38981.1 - 2.5e-24 86.0 0.8 2.5e-24 86.0 0.8 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC38981.1 - 7e-11 41.9 0.1 9.9e-09 34.9 0.1 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC38981.1 - 0.0038 16.1 0.1 0.006 15.4 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF3523 PF12037.8 EFC38981.1 - 0.0048 16.3 0.9 0.92 8.8 0.1 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF3523) DUF4853 PF16145.5 EFC38981.1 - 0.07 13.3 0.0 5.5 7.1 0.0 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4853) AvrPtoB_bdg PF16847.5 EFC38981.1 - 0.097 13.2 0.3 2.2 8.8 0.0 2.5 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain DUF1667 PF07892.11 EFC38981.1 - 0.099 12.7 0.0 63 3.7 0.0 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF1667) zf_C2H2_6 PF18450.1 EFC38981.1 - 1.4 8.7 5.4 7.5 6.4 0.0 4.1 5 0 0 5 5 5 0 Zinc Finger domain Ank_2 PF12796.7 EFC38982.1 - 3.9e-23 81.9 2.6 6.1e-08 33.2 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 EFC38982.1 - 7.4e-21 74.7 4.2 7.4e-21 74.7 4.2 2.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_3 PF13606.6 EFC38982.1 - 1.6e-16 58.7 3.2 0.00056 20.2 0.0 6.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFC38982.1 - 6.1e-16 58.3 1.2 0.0027 18.0 0.0 5.5 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC38982.1 - 1.9e-15 57.0 2.5 1.6e-08 34.9 0.0 4.6 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC38982.1 - 1.1e-12 47.7 1.2 0.0017 18.7 0.0 5.8 5 0 0 5 5 5 3 Ankyrin repeat DUF2852 PF11014.8 EFC38983.1 - 3.6 7.8 10.8 29 4.8 8.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2852) SSP160 PF06933.11 EFC38983.1 - 7.6 4.6 15.9 11 4.1 15.9 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 CSG2 PF16965.5 EFC38983.1 - 8.8 5.2 8.2 7.9 5.3 7.1 1.4 1 1 0 1 1 1 0 Ceramide synthase regulator EGF_2 PF07974.13 EFC38984.1 - 7.4e-51 170.2 357.7 0.00047 20.5 6.8 22.8 22 0 0 22 22 22 21 EGF-like domain Pkinase PF00069.25 EFC38984.1 - 2.7e-31 108.9 4.1 4.6e-31 108.2 4.1 1.4 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC38984.1 - 3.5e-23 80.4 3.6 1.7e-05 24.6 0.0 6.1 5 0 0 5 5 5 4 NHL repeat Pkinase_Tyr PF07714.17 EFC38984.1 - 1.9e-17 63.4 0.9 4.2e-17 62.3 0.9 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase TMEM154 PF15102.6 EFC38984.1 - 0.00065 19.6 0.2 0.0015 18.4 0.2 1.5 1 0 0 1 1 1 1 TMEM154 protein family Syndecan PF01034.20 EFC38984.1 - 0.0083 16.0 1.1 0.02 14.8 1.1 1.5 1 0 0 1 1 1 1 Syndecan domain MA3 PF02847.17 EFC38984.1 - 0.035 14.1 0.4 0.12 12.4 0.4 2.0 1 0 0 1 1 1 0 MA3 domain DUF5385 PF17359.2 EFC38984.1 - 0.069 12.7 1.7 0.12 11.9 1.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) TMEM51 PF15345.6 EFC38984.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4381 PF14316.6 EFC38984.1 - 0.12 12.6 0.1 0.23 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Orthoreo_P17 PF07272.11 EFC38984.1 - 0.13 12.3 0.8 4.4 7.3 0.2 2.7 2 0 0 2 2 2 0 Orthoreovirus P17 protein EGF PF00008.27 EFC38984.1 - 9.7 6.6 253.5 0.088 13.1 1.7 22.8 22 0 0 22 22 21 0 EGF-like domain DMPK_coil PF08826.10 EFC38985.1 - 0.77 9.9 6.2 1.7 8.8 2.4 2.2 1 1 1 2 2 2 0 DMPK coiled coil domain like DUF4864 PF16156.5 EFC38986.1 - 0.17 12.6 2.2 2.5 8.8 0.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4864) tRNA-synt_2e PF02091.15 EFC38986.1 - 0.64 9.2 10.5 0.51 9.5 0.4 2.9 1 1 2 3 3 3 0 Glycyl-tRNA synthetase alpha subunit DUF4116 PF13475.6 EFC38988.1 - 1.3e-31 108.1 3.8 2.5e-14 52.7 0.1 3.1 2 1 1 3 3 3 3 Domain of unknown function (DUF4116) CbiG_C PF01890.16 EFC38988.1 - 0.028 15.0 0.2 0.32 11.6 0.0 2.1 1 1 1 2 2 2 0 Cobalamin synthesis G C-terminus Pox_C4_C10 PF03336.13 EFC38988.1 - 0.039 13.1 0.4 0.042 13.0 0.4 1.0 1 0 0 1 1 1 0 Poxvirus C4/C10 protein Swm2 PF17083.5 EFC38988.1 - 0.039 14.0 0.7 0.14 12.1 0.6 1.8 1 1 0 1 1 1 0 Nucleolar protein Swm2 Bac_DnaA_C PF08299.11 EFC38988.1 - 0.08 13.0 0.4 0.27 11.3 0.3 1.9 1 1 1 2 2 2 0 Bacterial dnaA protein helix-turn-helix IBR PF01485.21 EFC38989.1 - 3.7e-15 55.9 50.7 3e-09 37.0 12.2 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFC38989.1 - 0.0055 16.6 9.1 0.0055 16.6 9.1 4.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC38989.1 - 0.016 15.2 5.8 0.016 15.2 5.8 3.4 3 0 0 3 3 3 0 RING-type zinc-finger zf-ribbon_3 PF13248.6 EFC38989.1 - 7.5 6.1 14.8 7.5 6.1 0.5 4.4 3 0 0 3 3 3 0 zinc-ribbon domain DUF2263 PF10021.9 EFC38990.1 - 6.1e-40 136.9 0.1 1e-39 136.2 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) DUF1820 PF08850.11 EFC38990.1 - 0.028 14.9 0.1 0.058 13.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1820) PARP PF00644.20 EFC38991.1 - 2.4e-26 92.5 2.2 2.4e-26 92.5 2.2 2.6 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain IZUMO PF15005.6 EFC38991.1 - 0.52 10.8 0.0 0.52 10.8 0.0 4.5 4 1 2 6 6 6 0 Izumo sperm-egg fusion, Ig domain-associated ISG65-75 PF11727.8 EFC38991.1 - 0.87 8.8 14.0 4.4 6.5 13.5 2.4 2 0 0 2 2 2 0 Invariant surface glycoprotein Epimerase PF01370.21 EFC38992.1 - 2.2e-15 56.8 0.1 3.2e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC38992.1 - 1.1e-14 54.1 0.7 4.7e-14 52.0 0.7 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC38992.1 - 2.3e-13 49.9 0.1 3e-13 49.5 0.1 1.1 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFC38992.1 - 1.5e-08 34.5 0.5 3.4e-08 33.3 0.5 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFC38992.1 - 1.2e-06 28.6 0.0 0.0056 16.6 0.0 2.9 2 1 1 3 3 3 2 NAD(P)H-binding NmrA PF05368.13 EFC38992.1 - 0.00013 21.6 0.0 0.00064 19.3 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family Roc PF08477.13 EFC38993.1 - 1.4e-09 38.2 0.0 1.6e-09 38.0 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC38993.1 - 1.7e-07 31.0 0.0 2.1e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFC38993.1 - 0.017 14.5 0.0 0.024 14.0 0.0 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF962 PF06127.11 EFC38994.1 - 1.2e-08 34.9 0.3 1.7e-08 34.4 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF962) Acetyltransf_7 PF13508.7 EFC38995.1 - 1.5e-05 25.3 0.0 3.7e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC38995.1 - 2.2e-05 24.4 0.0 5.1e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC38995.1 - 4.1e-05 23.8 0.0 8.5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFC38995.1 - 0.00033 20.6 0.0 0.00078 19.4 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFC38995.1 - 0.0018 18.4 0.0 0.0035 17.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EFC38995.1 - 0.023 14.2 0.0 0.077 12.5 0.0 1.7 2 0 0 2 2 2 0 Putative acetyl-transferase Acetyltransf_13 PF13880.6 EFC38995.1 - 0.073 13.1 0.0 0.34 10.9 0.0 2.3 2 1 0 2 2 2 0 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.7 EFC38995.1 - 0.1 13.2 0.0 0.2 12.3 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain MMR_HSR1 PF01926.23 EFC38996.1 - 1.9e-06 28.0 0.0 2.9e-06 27.3 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase IIGP PF05049.13 EFC38996.1 - 0.0009 18.4 0.0 0.002 17.3 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Dynamin_N PF00350.23 EFC38996.1 - 0.0016 18.5 0.1 0.0048 17.0 0.0 1.8 2 1 0 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.18 EFC38996.1 - 0.014 14.8 0.0 0.034 13.5 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family Roc PF08477.13 EFC38996.1 - 0.016 15.4 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC38996.1 - 0.022 13.9 0.0 0.036 13.2 0.0 1.5 1 1 0 1 1 1 0 G-protein alpha subunit AAA_24 PF13479.6 EFC38996.1 - 0.024 14.4 0.0 0.055 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC38996.1 - 0.038 14.3 0.0 0.45 10.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EFC38996.1 - 0.063 13.0 0.5 0.07 12.8 0.5 1.3 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EFC38996.1 - 0.068 12.4 0.2 0.18 11.1 0.0 1.8 3 0 0 3 3 3 0 Septin Ras PF00071.22 EFC38996.1 - 0.096 12.3 0.0 1 8.9 0.0 2.2 1 1 1 2 2 2 0 Ras family Antimicrobial19 PF08225.11 EFC38996.1 - 4.3 7.1 5.1 1.4 8.6 0.5 2.2 2 0 0 2 2 2 0 Pseudin antimicrobial peptide MMR_HSR1 PF01926.23 EFC38997.1 - 3.3e-05 23.9 0.0 3.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 EFC38997.1 - 0.00017 21.3 0.0 0.033 13.8 0.0 2.0 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 EFC38997.1 - 0.00022 21.6 0.0 0.00028 21.2 0.0 1.1 1 0 0 1 1 1 1 RNA helicase Roc PF08477.13 EFC38997.1 - 0.0036 17.5 0.0 0.0041 17.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC38997.1 - 0.0049 16.1 0.2 0.053 12.7 0.1 2.0 1 1 1 2 2 2 1 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EFC38997.1 - 0.0066 15.8 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AIG1 PF04548.16 EFC38997.1 - 0.0099 15.2 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.6 EFC38997.1 - 0.021 15.1 0.0 0.023 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EFC38997.1 - 0.022 14.8 0.0 0.072 13.1 0.0 1.8 2 0 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 EFC38997.1 - 0.03 14.7 0.0 0.031 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 EFC38997.1 - 0.056 12.5 0.0 0.077 12.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein CbiA PF01656.23 EFC38997.1 - 0.091 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain TniB PF05621.11 EFC38997.1 - 0.14 11.5 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein DUF815 PF05673.13 EFC38997.1 - 0.16 11.1 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) VirE PF05272.11 EFC38997.1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.4 1 1 0 1 1 1 0 Virulence-associated protein E DUF4874 PF16173.5 EFC38998.1 - 0.11 12.2 3.8 4.2 7.0 0.1 3.6 3 1 0 4 4 4 0 Domain of unknown function (DUF4874) TPR_1 PF00515.28 EFC38999.1 - 7.9e-27 91.9 10.4 1.2e-05 24.9 0.2 7.8 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC38999.1 - 4.1e-26 88.9 1.1 0.00033 20.5 0.1 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC38999.1 - 1.5e-17 62.3 3.7 0.015 15.4 0.1 6.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC38999.1 - 5.1e-17 61.9 0.1 0.00038 20.7 0.0 6.3 4 2 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC38999.1 - 7.1e-13 48.0 4.8 0.014 15.0 0.0 6.0 5 1 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 EFC38999.1 - 1.7e-10 40.2 0.2 0.27 11.4 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC38999.1 - 1.1e-09 38.7 0.0 8.5e-05 23.0 0.0 3.6 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC38999.1 - 1e-08 35.2 0.2 4.3 8.2 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC38999.1 - 1.1e-08 35.1 3.4 0.017 15.3 0.0 4.9 3 1 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFC38999.1 - 1.3e-08 35.4 0.0 0.0027 18.3 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC38999.1 - 8.6e-08 32.4 0.0 0.11 13.3 0.0 5.3 3 1 3 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC38999.1 - 5.4e-06 26.4 0.2 4.5 7.9 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC38999.1 - 5e-05 23.0 0.0 23 5.0 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC38999.1 - 0.00071 19.7 0.0 1.2 9.3 0.0 4.0 3 1 2 5 5 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC38999.1 - 0.0038 17.3 0.2 3.6 7.7 0.0 4.2 4 1 1 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat DUF5113 PF17140.4 EFC38999.1 - 0.0044 16.9 1.8 1.5 8.6 0.0 3.7 3 1 1 4 4 4 1 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 EFC38999.1 - 0.01 15.3 0.0 0.12 11.7 0.0 2.7 2 1 1 3 3 3 0 MalT-like TPR region DUF2959 PF11172.8 EFC38999.1 - 0.019 15.1 0.2 8.2 6.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2959) NARP1 PF12569.8 EFC38999.1 - 0.022 13.7 0.3 0.4 9.5 0.1 2.4 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 MIT PF04212.18 EFC38999.1 - 0.11 12.6 0.7 1e+02 3.1 0.0 4.7 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 EFC38999.1 - 0.2 12.0 3.0 1.5e+02 3.0 0.0 4.6 5 0 0 5 5 4 0 PPR repeat Pkinase PF00069.25 EFC39002.1 - 4.7e-75 252.4 0.0 5.4e-75 252.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39002.1 - 3e-34 118.5 0.0 3.9e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC39002.1 - 2.2e-06 26.9 0.5 6.3e-05 22.1 0.5 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC39002.1 - 0.00043 19.7 0.2 0.00066 19.1 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC39002.1 - 0.0031 16.9 0.3 0.27 10.5 0.0 2.3 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EFC39002.1 - 0.0042 16.7 0.1 0.0066 16.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFC39002.1 - 0.011 15.7 0.0 0.021 14.7 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC39002.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase RCC1 PF00415.18 EFC39003.1 - 4.6e-10 40.0 0.0 1.6e-06 28.6 0.0 3.7 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39003.1 - 0.005 16.6 4.5 1.2 9.0 0.1 3.6 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat PI3Ka PF00613.20 EFC39004.1 - 7.5e-13 48.3 1.1 1.9e-12 47.0 1.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) LRR_9 PF14580.6 EFC39004.1 - 0.085 12.4 8.0 0.21 11.1 0.4 3.1 1 1 2 3 3 3 0 Leucine-rich repeat LRR_4 PF12799.7 EFC39004.1 - 0.16 12.5 20.9 0.061 13.8 2.9 6.0 3 3 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39004.1 - 0.23 11.3 9.6 0.23 11.2 1.2 3.9 2 1 1 4 4 4 0 Leucine rich repeat DUF676 PF05057.14 EFC39005.1 - 1.9e-24 86.4 0.0 4.1e-24 85.3 0.0 1.5 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EFC39005.1 - 1.3e-05 25.1 0.0 4.2e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) PGAP1 PF07819.13 EFC39005.1 - 0.0011 18.8 0.1 0.0026 17.5 0.0 1.7 2 0 0 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 EFC39005.1 - 0.012 15.5 0.0 0.028 14.2 0.0 1.8 1 1 0 1 1 1 0 Palmitoyl protein thioesterase DUF432 PF04254.13 EFC39005.1 - 0.08 13.1 0.1 2.7 8.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF432) Kelch_4 PF13418.6 EFC39007.1 - 1.4e-24 85.8 5.7 8.1e-07 29.0 0.2 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC39007.1 - 3.9e-19 68.2 11.3 4.3e-05 23.6 0.0 6.2 5 1 1 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFC39007.1 - 5.1e-16 58.5 0.5 0.0042 17.3 0.1 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC39007.1 - 1.2e-13 50.4 9.2 0.0003 20.3 0.4 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFC39007.1 - 1.6e-11 43.7 11.0 0.00025 20.9 0.3 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 EFC39007.1 - 2.3e-09 37.1 11.9 0.00045 20.2 0.3 5.5 6 0 0 6 6 6 3 Kelch motif Nop14 PF04147.12 EFC39007.1 - 4.4 5.4 12.0 5.3 5.1 12.0 1.0 1 0 0 1 1 1 0 Nop14-like family Metallophos PF00149.28 EFC39008.1 - 1.9e-12 48.1 1.4 3.2e-12 47.4 1.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC39008.1 - 1.6e-09 38.1 0.0 4.1e-09 36.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Zn_clus PF00172.18 EFC39009.1 - 7.4e-08 32.4 10.1 1.4e-07 31.5 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2OG-FeII_Oxy_3 PF13640.6 EFC39010.1 - 2e-08 35.0 0.0 3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EFC39010.1 - 0.022 15.4 0.1 0.059 14.0 0.1 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PAD PF03068.15 EFC39010.1 - 0.052 12.5 0.0 0.073 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) LRR_4 PF12799.7 EFC39011.1 - 6.6e-09 35.9 47.7 0.0019 18.5 5.2 9.5 5 4 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39011.1 - 0.0011 18.7 25.5 0.036 13.8 0.3 6.5 4 1 1 5 5 5 3 Leucine rich repeat Phage_spike_2 PF18781.1 EFC39011.1 - 0.058 13.4 0.3 0.3 11.1 0.0 2.3 2 0 0 2 2 2 0 Phage spike trimer DUF4332 PF14229.6 EFC39011.1 - 0.16 12.3 1.8 1.9 8.7 0.4 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4332) NHL PF01436.21 EFC39012.1 - 0.019 15.0 0.2 34 4.7 0.1 3.7 3 0 0 3 3 3 0 NHL repeat Abhydrolase_3 PF07859.13 EFC39013.1 - 6.6e-09 35.9 0.0 4.6e-08 33.2 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC39013.1 - 1.1e-07 31.0 1.1 1.6e-07 30.6 1.1 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Plavaka PF18759.1 EFC39013.1 - 0.0078 15.5 0.1 0.013 14.8 0.1 1.3 1 0 0 1 1 1 1 Plavaka transposase LIDHydrolase PF10230.9 EFC39013.1 - 0.024 14.2 0.0 0.077 12.5 0.0 1.8 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_2 PF02230.16 EFC39013.1 - 0.026 14.3 0.0 0.085 12.6 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Phage_min_cap2 PF06152.11 EFC39013.1 - 0.06 12.2 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 Peptidase_S9 PF00326.21 EFC39013.1 - 0.14 11.6 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Prolyl oligopeptidase family XRN_N PF03159.18 EFC39014.1 - 1.3e-93 312.9 0.1 1.3e-93 312.9 0.1 2.5 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFC39014.1 - 1.7e-31 109.7 0.1 1.7e-31 109.7 0.1 2.8 2 1 1 3 3 3 1 Xrn1 helical domain XRN1_D1 PF18332.1 EFC39014.1 - 1.1e-20 74.2 0.0 1.1e-20 74.2 0.0 2.9 3 0 0 3 3 3 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 EFC39014.1 - 1.1e-13 51.0 0.4 2.1e-13 50.1 0.4 1.5 1 0 0 1 1 1 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 EFC39014.1 - 6.2e-09 36.0 0.0 3e-08 33.7 0.0 2.3 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain FH2 PF02181.23 EFC39015.1 - 7.5e-61 206.3 18.4 7.5e-61 206.3 18.4 2.9 3 0 0 3 3 3 1 Formin Homology 2 Domain DUF3800 PF12686.7 EFC39015.1 - 0.38 11.4 4.3 1.4e+02 3.1 4.2 4.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) CdiI_2 PF18593.1 EFC39015.1 - 0.53 11.0 3.8 7.5 7.3 0.1 3.8 3 0 0 3 3 3 0 CdiI immunity protein FH2 PF02181.23 EFC39016.1 - 2.9e-60 204.4 17.3 2.9e-60 204.4 17.3 4.1 3 2 1 4 4 4 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFC39016.1 - 1.5e-09 37.7 2.7 1.5e-09 37.7 2.7 4.0 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFC39016.1 - 5.3e-07 29.4 1.2 5.3e-07 29.4 1.2 4.2 2 1 1 3 3 3 1 Diaphanous FH3 Domain DUF866 PF05907.13 EFC39017.1 - 1.2e-37 129.2 4.7 1.4e-37 129.0 4.7 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) zinc_ribbon_4 PF13717.6 EFC39017.1 - 0.084 12.8 2.4 0.17 11.8 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 EFC39017.1 - 0.21 11.6 5.6 0.82 9.7 5.6 1.9 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Sgf11 PF08209.11 EFC39017.1 - 0.49 10.0 4.7 11 5.7 0.4 2.5 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) E7 PF00527.18 EFC39017.1 - 4.2 7.6 6.4 19 5.5 0.3 2.7 2 1 1 3 3 3 0 E7 protein, Early protein SBP_bac_3 PF00497.20 EFC39018.1 - 1.9e-11 43.8 0.1 3.2e-11 43.1 0.1 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 BTB PF00651.31 EFC39019.1 - 1.3e-09 38.3 1.9 3.7e-09 36.8 0.4 2.6 3 0 0 3 3 3 1 BTB/POZ domain Ank_2 PF12796.7 EFC39019.1 - 1.9e-07 31.6 0.0 5.2e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC39019.1 - 0.00012 22.3 0.0 0.0004 20.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC39019.1 - 0.00028 21.4 0.0 0.00081 19.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC39019.1 - 0.0016 18.8 0.1 0.0055 17.1 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.30 EFC39019.1 - 0.0043 17.4 0.1 0.013 16.0 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeat adh_short_C2 PF13561.6 EFC39020.1 - 9e-62 208.7 0.0 1.2e-61 208.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC39020.1 - 6.2e-50 169.4 0.0 7.9e-50 169.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC39020.1 - 7.6e-10 39.0 0.0 1.1e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC39020.1 - 0.0022 17.2 0.0 0.003 16.7 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 EFC39020.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Hydantoinase_B PF02538.14 EFC39020.1 - 0.048 12.1 0.1 0.063 11.7 0.1 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase GDP_Man_Dehyd PF16363.5 EFC39020.1 - 0.082 12.3 0.1 0.11 11.9 0.1 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF1776 PF08643.10 EFC39020.1 - 0.16 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF4115 PF13464.6 EFC39021.1 - 0.0083 16.3 0.7 0.94 9.7 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4115) Laminin_I PF06008.14 EFC39021.1 - 0.12 12.1 14.5 0.16 11.6 14.5 1.1 1 0 0 1 1 1 0 Laminin Domain I TM2 PF05154.16 EFC39021.1 - 0.35 11.3 1.9 0.54 10.6 1.9 1.3 1 0 0 1 1 1 0 TM2 domain LMBR1 PF04791.16 EFC39021.1 - 3.2 6.6 7.0 4.2 6.2 7.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein NHL PF01436.21 EFC39022.1 - 1.6e-29 100.4 8.1 2e-05 24.4 0.1 5.8 5 1 0 5 5 5 5 NHL repeat TGT_C2 PF14810.6 EFC39022.1 - 0.00014 21.9 0.0 3.3 7.9 0.0 4.4 5 0 0 5 5 5 1 Patch-forming domain C2 of tRNA-guanine transglycosylase DUF1236 PF06823.12 EFC39022.1 - 0.0019 18.1 0.2 60 3.6 0.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1236) adh_short PF00106.25 EFC39023.1 - 2.2e-16 59.9 0.0 9.8e-15 54.5 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39023.1 - 1.3e-11 44.6 0.0 2.3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39023.1 - 2.1e-05 24.5 0.0 5.2e-05 23.2 0.0 1.7 1 1 1 2 2 2 1 KR domain PAE PF03283.13 EFC39023.1 - 0.0025 17.0 0.0 0.0035 16.5 0.0 1.2 1 0 0 1 1 1 1 Pectinacetylesterase cEGF PF12662.7 EFC39024.1 - 4.5 7.3 10.9 24 5.0 3.7 3.3 3 0 0 3 3 3 0 Complement Clr-like EGF-like DUF641 PF04859.12 EFC39025.1 - 0.0022 18.3 8.1 0.0022 18.3 8.1 1.9 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Phage_GPO PF05929.11 EFC39025.1 - 0.03 14.0 5.3 0.061 12.9 5.3 1.5 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HMMR_N PF15905.5 EFC39025.1 - 1.8 7.9 20.6 0.034 13.6 13.1 1.8 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Fes1 PF08609.10 EFC39025.1 - 1.9 9.4 14.4 0.68 10.9 5.0 2.9 3 1 0 3 3 3 0 Nucleotide exchange factor Fes1 CCDC106 PF15794.5 EFC39025.1 - 2.6 7.7 16.2 0.031 14.0 7.2 2.3 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 106 Csm1_N PF18504.1 EFC39025.1 - 2.8 8.3 18.2 0.079 13.3 3.0 3.3 2 1 1 3 3 3 0 Csm1 N-terminal domain Seryl_tRNA_N PF02403.22 EFC39025.1 - 4.1 7.7 15.1 0.62 10.3 10.8 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SlyX PF04102.12 EFC39025.1 - 4.7 7.9 9.7 1.5 9.5 6.2 2.0 2 0 0 2 2 2 0 SlyX NHL PF01436.21 EFC39026.1 - 5.7e-29 98.7 19.0 3e-08 33.3 0.6 7.1 8 0 0 8 8 8 4 NHL repeat SGL PF08450.12 EFC39026.1 - 1.3e-05 25.0 0.3 0.029 14.0 0.0 4.2 2 1 3 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region DUF4934 PF16288.5 EFC39026.1 - 5.2e-05 23.1 3.8 0.21 11.5 0.0 4.0 3 1 1 4 4 4 2 Domain of unknown function (DUF4934) DUF5128 PF17170.4 EFC39026.1 - 7.5e-05 22.0 17.0 0.016 14.4 1.0 4.5 3 1 1 5 5 5 2 6-bladed beta-propeller zf-B_box PF00643.24 EFC39026.1 - 0.00069 19.7 13.4 0.00069 19.7 13.4 2.4 2 0 0 2 2 2 1 B-box zinc finger Phytase-like PF13449.6 EFC39026.1 - 0.0011 19.0 0.0 0.1 12.5 0.0 2.8 1 1 1 2 2 2 1 Esterase-like activity of phytase PQQ_3 PF13570.6 EFC39026.1 - 0.13 12.8 0.2 4.7 7.8 0.0 3.0 2 0 0 2 2 2 0 PQQ-like domain YkyA PF10368.9 EFC39026.1 - 5.5 6.6 12.0 44 3.7 8.5 2.4 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein TLD PF07534.16 EFC39027.1 - 8.9e-22 77.8 0.3 1.3e-21 77.2 0.3 1.3 1 0 0 1 1 1 1 TLD DUF4834 PF16118.5 EFC39027.1 - 0.11 13.5 0.7 0.23 12.4 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MSP1a PF11670.8 EFC39027.1 - 0.23 10.7 1.0 0.35 10.1 1.0 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) TPK_catalytic PF04263.16 EFC39028.1 - 0.11 12.5 0.0 0.37 10.8 0.0 1.9 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain LBP_C PF17386.2 EFC39028.1 - 0.84 9.6 3.7 42 4.1 1.8 2.9 2 0 0 2 2 2 0 Lacto-N-biose phosphorylase C-terminal domain DUF563 PF04577.14 EFC39031.1 - 3.7e-32 112.2 0.1 5.2e-32 111.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) SPRY PF00622.28 EFC39033.1 - 0.00028 21.0 0.2 0.0019 18.3 0.1 2.4 2 0 0 2 2 2 1 SPRY domain F-box-like PF12937.7 EFC39033.1 - 0.069 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 F-box-like Pes-10 PF07149.11 EFC39033.1 - 1.8 7.6 14.4 3.7 6.5 14.4 1.5 1 0 0 1 1 1 0 Pes-10 Trypsin_2 PF13365.6 EFC39034.1 - 0.006 17.5 0.0 0.015 16.2 0.0 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain Ephrin_rec_like PF07699.13 EFC39034.1 - 0.016 14.9 0.7 0.5 10.2 0.7 2.6 1 1 0 1 1 1 0 Putative ephrin-receptor like EGF_2 PF07974.13 EFC39035.1 - 3e-93 305.8 629.7 0.0001 22.6 7.4 36.0 34 2 2 36 36 36 35 EGF-like domain RGS PF00615.19 EFC39035.1 - 1.7e-05 25.1 0.2 6.3e-05 23.2 0.2 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain EGF PF00008.27 EFC39035.1 - 0.00086 19.6 15.6 0.0011 19.2 6.3 36.7 37 0 0 37 37 37 21 EGF-like domain Arm_vescicular PF18770.1 EFC39036.1 - 0.19 11.7 0.1 0.48 10.4 0.1 1.6 1 0 0 1 1 1 0 Armadillo tether-repeat of vescicular transport factor CelTOS PF18659.1 EFC39036.1 - 0.66 10.4 4.2 0.45 11.0 0.1 2.7 3 0 0 3 3 3 0 Cell-traversal protein for ookinetes and sporozoites Csm2_III-A PF03750.13 EFC39036.1 - 2 9.3 4.7 1.6 9.6 0.1 3.1 3 1 1 4 4 4 0 Csm2 Type III-A Trypan_PARP PF05887.11 EFC39037.1 - 5e-06 26.5 89.4 1.8e+04 -26.9 89.4 3.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Bac_A_amyl_C PF18612.1 EFC39038.1 - 0.029 14.1 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain PRP1_N PF06424.12 EFC39038.1 - 0.17 12.3 12.6 0.37 11.2 12.6 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal PMSI1 PF15322.6 EFC39038.1 - 0.88 9.0 4.5 1.3 8.4 4.5 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Presenilin PF01080.17 EFC39038.1 - 1 8.1 6.2 1.1 8.0 6.2 1.2 1 0 0 1 1 1 0 Presenilin PIEZO PF15917.5 EFC39038.1 - 1.2 8.6 9.7 2 7.8 9.7 1.3 1 0 0 1 1 1 0 Piezo CAC1F_C PF16885.5 EFC39038.1 - 2 8.0 9.5 0.074 12.7 3.1 1.7 1 1 1 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term LRIF1 PF15741.5 EFC39038.1 - 2.1 6.8 16.6 2 6.9 12.6 2.0 1 1 0 2 2 2 0 Ligand-dependent nuclear receptor-interacting factor 1 dCMP_cyt_deam_1 PF00383.23 EFC39039.1 - 7.2e-27 93.2 1.8 1.2e-26 92.5 1.8 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFC39039.1 - 3.2e-26 91.7 2.3 7.8e-26 90.5 2.3 1.7 1 1 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 EFC39039.1 - 2.3e-05 24.5 0.5 5.9e-05 23.2 0.1 1.8 2 0 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 EFC39039.1 - 0.00075 19.6 0.1 0.0013 18.8 0.1 1.4 1 0 0 1 1 1 1 APOBEC2 APOBEC3 PF18771.1 EFC39039.1 - 0.00083 19.5 0.2 0.0016 18.6 0.2 1.4 1 0 0 1 1 1 1 APOBEC3 Inv-AAD PF18785.1 EFC39039.1 - 0.0015 18.4 0.2 0.0032 17.3 0.2 1.5 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase NAD1 PF18778.1 EFC39039.1 - 0.0024 18.0 0.5 0.0038 17.3 0.1 1.6 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC4_like PF18774.1 EFC39039.1 - 0.005 16.8 0.1 0.011 15.7 0.1 1.6 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase NAD2 PF18782.1 EFC39039.1 - 0.012 15.7 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 Bd3614-deam PF14439.6 EFC39039.1 - 0.034 14.2 2.0 0.13 12.3 2.0 1.9 1 1 0 1 1 1 0 Bd3614-like deaminase zf-RING_11 PF17123.5 EFC39040.1 - 1.3e-06 28.0 1.1 1.3e-06 28.0 1.1 2.7 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFC39040.1 - 0.0057 16.5 7.2 0.0057 16.5 7.2 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC39040.1 - 0.094 13.1 18.3 0.022 15.1 14.3 2.2 2 0 0 2 2 2 0 Ring finger domain zf-ANAPC11 PF12861.7 EFC39040.1 - 0.1 12.7 5.6 0.25 11.4 5.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EFC39040.1 - 0.15 12.1 14.8 0.084 12.8 11.3 2.4 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.25 EFC39040.1 - 0.94 9.4 16.2 0.3 11.0 12.0 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) EIF_2_alpha PF07541.12 EFC39040.1 - 2.9 8.0 5.5 3.2 7.9 0.4 3.8 4 1 0 4 4 4 0 Eukaryotic translation initiation factor 2 alpha subunit Zip PF02535.22 EFC39041.1 - 6.6e-29 101.2 13.9 5.8e-27 94.8 13.9 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter DUF1398 PF07166.11 EFC39042.1 - 2.1e-10 40.7 0.0 2.7e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1398) Zn_clus PF00172.18 EFC39043.1 - 3.5e-08 33.5 10.8 7.6e-08 32.4 10.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_12 PF13424.6 EFC39043.1 - 0.074 13.4 0.6 0.18 12.1 0.6 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SIR2 PF02146.17 EFC39044.1 - 4.3e-05 23.5 5.2 0.00076 19.5 4.6 2.2 1 1 1 2 2 2 2 Sir2 family Peptidase_M1 PF01433.20 EFC39045.1 - 1.3e-22 80.4 0.1 2.2e-22 79.7 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EFC39045.1 - 1.4e-19 71.0 8.0 1.4e-19 71.0 8.0 2.6 2 1 0 2 2 2 1 Peptidase M1 N-terminal domain DUF4171 PF13775.6 EFC39045.1 - 0.081 13.4 11.6 0.039 14.4 7.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4171) SNF2_N PF00176.23 EFC39046.1 - 5.1e-67 226.1 1.5 5.1e-67 226.1 1.5 2.9 3 1 0 3 3 3 1 SNF2 family N-terminal domain SLIDE PF09111.10 EFC39046.1 - 2.4e-39 133.9 3.6 2.4e-39 133.9 3.6 4.5 5 2 0 5 5 5 1 SLIDE Helicase_C PF00271.31 EFC39046.1 - 7.4e-21 74.6 2.2 1.8e-20 73.3 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC39046.1 - 1.7e-05 24.6 0.2 0.0006 19.6 0.0 2.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 EFC39046.1 - 0.00035 20.7 8.2 0.036 14.3 0.0 3.2 3 0 0 3 3 3 2 Myb-like DNA-binding domain ABC_membrane PF00664.23 EFC39047.1 - 4.8e-53 180.6 17.6 6.3e-53 180.2 17.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC39047.1 - 2.3e-32 112.4 0.0 4.2e-32 111.5 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC39047.1 - 9.5e-07 28.5 1.7 0.00025 20.6 1.7 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC39047.1 - 0.00082 19.1 0.7 0.0028 17.4 0.2 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC39047.1 - 0.003 18.0 0.1 0.01 16.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EFC39047.1 - 0.0086 15.8 0.0 0.023 14.4 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 EFC39047.1 - 0.01 15.5 0.1 0.16 11.6 0.0 2.6 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 EFC39047.1 - 0.017 15.0 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 EFC39047.1 - 0.034 14.6 0.5 1.4 9.3 0.5 2.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 EFC39047.1 - 0.047 12.5 0.4 0.099 11.4 0.0 1.6 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_22 PF13401.6 EFC39047.1 - 0.065 13.5 0.2 0.45 10.8 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFC39047.1 - 0.097 12.8 0.3 1 9.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EFC39047.1 - 0.12 12.1 0.1 2.7 7.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 EFC39047.1 - 0.13 11.8 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF5131 PF07505.11 EFC39048.1 - 0.0023 17.4 0.4 0.0029 17.1 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF5131) RRM_1 PF00076.22 EFC39049.1 - 0.00016 21.4 0.2 0.00024 20.8 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_31 PF13614.6 EFC39049.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain Abhydrolase_3 PF07859.13 EFC39050.1 - 6.2e-44 150.4 0.0 8.1e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFC39050.1 - 1.3e-13 50.7 0.2 8.3e-13 48.0 0.2 2.0 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EFC39050.1 - 8.4e-07 28.2 0.2 2.4e-06 26.7 0.1 1.6 1 1 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 EFC39050.1 - 7.7e-06 25.0 0.0 1.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EFC39050.1 - 1.6e-05 24.1 0.0 2.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase PAF-AH_p_II PF03403.13 EFC39050.1 - 0.036 12.6 0.0 0.063 11.8 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Esterase PF00756.20 EFC39050.1 - 0.14 11.8 0.0 14 5.2 0.0 2.2 2 0 0 2 2 2 0 Putative esterase HEAT PF02985.22 EFC39051.1 - 2.7e-06 27.2 2.4 0.043 14.1 0.0 4.4 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 EFC39051.1 - 1.1e-05 25.8 0.2 0.11 12.9 0.2 3.8 2 1 1 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 EFC39051.1 - 0.11 13.1 9.1 0.47 11.1 0.2 5.4 5 1 1 6 6 6 0 Vacuolar 14 Fab1-binding region UPF0524 PF15823.5 EFC39051.1 - 0.15 11.4 7.8 0.79 9.1 7.8 2.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 RTP1_C1 PF10363.9 EFC39051.1 - 0.27 11.4 5.0 0.5 10.6 0.4 3.9 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 EFC39051.1 - 0.3 11.4 2.4 7.1 7.0 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Zn_ribbon_2 PF12674.7 EFC39051.1 - 2.6 8.8 5.3 1.7 9.4 0.1 3.7 3 0 0 3 3 3 0 Putative zinc ribbon domain ADH_zinc_N PF00107.26 EFC39052.1 - 7.7e-27 93.8 0.1 1.2e-26 93.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC39052.1 - 8.8e-13 49.5 0.0 1.5e-12 48.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC39052.1 - 2.6e-07 30.5 0.8 1.5e-06 28.0 0.1 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFC39052.1 - 0.00011 21.6 0.1 0.00017 21.0 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Eno-Rase_NADH_b PF12242.8 EFC39052.1 - 0.0036 17.0 0.3 0.0088 15.8 0.3 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase adh_short PF00106.25 EFC39052.1 - 0.013 15.0 0.9 0.017 14.6 0.1 1.6 2 0 0 2 2 2 0 short chain dehydrogenase ELFV_dehydrog PF00208.21 EFC39052.1 - 0.015 15.1 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pkinase PF00069.25 EFC39053.1 - 4.9e-15 55.6 0.5 1.1e-14 54.5 0.5 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39053.1 - 1.4e-07 31.1 0.1 2.4e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Cofilin_ADF PF00241.20 EFC39053.1 - 0.0087 15.9 0.0 0.025 14.4 0.0 1.8 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF4116 PF13475.6 EFC39055.1 - 9.4e-55 182.1 2.7 1.8e-16 59.5 0.1 4.3 2 2 2 4 4 4 4 Domain of unknown function (DUF4116) zf_C2H2_6 PF18450.1 EFC39055.1 - 0.0018 17.9 0.0 2.2 8.1 0.0 3.0 3 0 0 3 3 3 2 Zinc Finger domain GA-like PF17573.2 EFC39055.1 - 0.1 12.5 0.0 10 6.1 0.1 2.4 1 1 1 2 2 2 0 GA-like domain Hpr_kinase_N PF02603.16 EFC39055.1 - 0.11 12.5 0.0 0.72 9.9 0.0 2.1 1 1 1 2 2 2 0 HPr Serine kinase N terminus CDKN3 PF05706.12 EFC39056.1 - 4.3e-14 52.5 0.4 1e-13 51.3 0.1 1.6 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) DSPc PF00782.20 EFC39056.1 - 9.6e-07 28.7 0.1 2.2e-06 27.5 0.1 1.7 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC39056.1 - 7.9e-06 25.6 1.3 0.00011 21.8 0.3 2.1 1 1 1 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFC39056.1 - 0.00025 21.1 0.0 0.00036 20.6 0.0 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFC39056.1 - 0.0003 20.9 0.0 0.00046 20.3 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Rhodanese PF00581.20 EFC39056.1 - 0.0023 18.4 0.0 0.059 13.9 0.0 2.2 1 1 1 2 2 2 1 Rhodanese-like domain Init_tRNA_PT PF04179.12 EFC39056.1 - 0.011 16.0 0.1 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 Rit1 DUSP-like domain DUF1256 PF06866.11 EFC39056.1 - 0.053 12.9 0.1 1.8 8.0 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1256) GSP_synth PF03738.14 EFC39056.1 - 0.1 11.8 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Glutathionylspermidine synthase preATP-grasp DAGK_cat PF00781.24 EFC39056.1 - 0.15 11.7 0.0 1.1 8.8 0.0 2.0 1 1 1 2 2 2 0 Diacylglycerol kinase catalytic domain V-SNARE PF05008.15 EFC39057.1 - 3.8e-16 59.2 3.5 3.8e-16 59.2 3.5 2.4 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 EFC39057.1 - 8.9e-13 48.3 5.2 2.5e-12 46.9 2.4 2.3 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFC39057.1 - 5.1e-07 29.5 6.4 1.4e-06 28.1 0.2 3.6 2 2 3 5 5 5 1 Sec20 DUF4407 PF14362.6 EFC39057.1 - 0.00034 20.1 0.7 0.00048 19.6 0.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF5089 PF17002.5 EFC39057.1 - 0.00063 19.7 0.4 0.00063 19.7 0.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF5089) DUF5534 PF17686.1 EFC39057.1 - 0.016 15.5 1.1 0.025 14.9 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5534) Atg14 PF10186.9 EFC39057.1 - 0.025 13.7 10.0 0.043 12.9 10.0 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CCDC-167 PF15188.6 EFC39057.1 - 0.029 14.7 1.7 0.029 14.7 1.7 3.2 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 COOH-NH2_lig PF14395.6 EFC39057.1 - 0.032 13.5 0.1 0.064 12.5 0.0 1.4 2 0 0 2 2 2 0 Phage phiEco32-like COOH.NH2 ligase-type 2 Fusion_gly PF00523.18 EFC39057.1 - 0.058 11.6 3.9 1.8 6.7 0.0 2.7 3 0 0 3 3 3 0 Fusion glycoprotein F0 MetOD2 PF18548.1 EFC39057.1 - 0.081 13.0 5.0 5 7.3 0.1 2.9 2 1 1 3 3 3 0 Metanogen output domain 2 DUF883 PF05957.13 EFC39057.1 - 0.17 12.5 7.8 0.17 12.5 0.7 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF2721 PF11026.8 EFC39057.1 - 0.2 11.6 2.1 0.27 11.1 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) THOC7 PF05615.13 EFC39057.1 - 0.32 11.3 9.1 0.34 11.2 3.2 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 DUF2205 PF10224.9 EFC39057.1 - 0.6 10.1 5.6 1.2 9.2 0.2 3.2 1 1 3 4 4 4 0 Short coiled-coil protein Enkurin PF13864.6 EFC39057.1 - 0.65 10.5 10.8 0.038 14.4 4.1 2.1 2 1 0 2 2 2 0 Calmodulin-binding PRKG1_interact PF15898.5 EFC39057.1 - 1 10.3 14.2 0.52 11.2 7.4 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YlqD PF11068.8 EFC39057.1 - 1.8 8.9 11.1 0.22 11.9 3.1 2.3 2 1 0 2 2 2 0 YlqD protein KxDL PF10241.9 EFC39057.1 - 2.5 8.4 10.8 0.47 10.8 1.0 3.3 2 2 1 3 3 3 0 Uncharacterized conserved protein Sigma_reg_N PF13800.6 EFC39057.1 - 2.6 8.4 6.5 5.2 7.4 6.5 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal TMF_DNA_bd PF12329.8 EFC39057.1 - 4.8 7.2 15.2 0.37 10.8 6.6 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Syndecan PF01034.20 EFC39057.1 - 6.8 6.7 6.1 18 5.3 6.1 1.7 1 0 0 1 1 1 0 Syndecan domain DUF2207 PF09972.9 EFC39057.1 - 8 5.1 10.8 53 2.4 10.8 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) OmpH PF03938.14 EFC39057.1 - 8.6 6.7 12.6 5.2 7.4 6.9 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Collagen PF01391.18 EFC39059.1 - 1e-06 28.4 16.6 1e-06 28.4 16.6 3.4 3 0 0 3 3 3 1 Collagen triple helix repeat (20 copies) Kelch_5 PF13854.6 EFC39060.1 - 2.5e-32 110.3 0.5 6.5e-06 26.0 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFC39060.1 - 1e-30 105.5 4.3 8.9e-06 25.6 0.1 6.3 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC39060.1 - 4.4e-26 90.3 5.8 4.6e-05 23.5 0.1 5.7 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFC39060.1 - 2.3e-23 82.0 1.1 7.8e-05 22.9 0.0 7.0 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC39060.1 - 4.4e-23 80.6 0.0 0.00023 20.7 0.1 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EFC39060.1 - 8.9e-16 57.2 6.3 0.00089 19.1 0.0 5.8 5 0 0 5 5 5 5 Kelch motif DUF1700 PF08006.11 EFC39060.1 - 0.034 13.7 0.4 0.07 12.7 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) F-box-like PF12937.7 EFC39060.1 - 0.046 13.6 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 F-box-like Syntaxin_2 PF14523.6 EFC39060.1 - 0.79 10.1 6.1 2.3 8.7 0.1 3.1 2 1 0 2 2 2 0 Syntaxin-like protein DASH_Dad3 PF08656.10 EFC39060.1 - 1.4 9.0 4.1 0.45 10.6 0.2 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad3 BTB PF00651.31 EFC39061.1 - 1.7e-15 57.2 0.4 1.7e-15 57.2 0.4 1.8 2 0 0 2 2 2 1 BTB/POZ domain ANAPC3 PF12895.7 EFC39063.1 - 0.005 17.0 0.9 4.3 7.6 0.1 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC39063.1 - 0.044 14.3 0.1 4.2 8.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39063.1 - 0.064 13.4 0.8 23 5.4 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat LRR_4 PF12799.7 EFC39065.1 - 0.0052 17.2 22.2 0.34 11.4 0.1 8.1 4 3 1 6 6 6 3 Leucine Rich repeats (2 copies) Sigma70_ner PF04546.13 EFC39066.1 - 0.19 11.6 0.2 0.34 10.8 0.2 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4116 PF13475.6 EFC39067.1 - 7e-20 70.5 6.8 2.9e-10 39.7 0.0 5.3 3 1 0 4 4 4 3 Domain of unknown function (DUF4116) Med11 PF10280.9 EFC39068.1 - 0.0089 16.5 0.1 0.023 15.2 0.1 1.6 1 0 0 1 1 1 1 Mediator complex protein AATF-Che1 PF13339.6 EFC39068.1 - 2 9.1 5.2 1.7 9.3 0.3 2.1 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor Got1 PF04178.12 EFC39069.1 - 1.3e-27 96.5 19.9 2.2e-27 95.7 19.9 1.4 1 0 0 1 1 1 1 Got1/Sft2-like family DUF5024 PF16427.5 EFC39069.1 - 0.024 15.0 0.6 0.056 13.8 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5024) tRNA-synt_2 PF00152.20 EFC39070.1 - 3.6e-30 105.1 0.2 6.8e-30 104.2 0.2 1.4 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFC39070.1 - 8.1e-05 22.5 0.1 0.00015 21.7 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Epimerase PF01370.21 EFC39071.1 - 2.6e-10 40.2 0.0 9.5e-09 35.1 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC39071.1 - 1.5e-06 27.8 0.1 0.0095 15.4 0.0 2.4 3 0 0 3 3 3 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC39071.1 - 0.00012 21.2 0.0 0.00048 19.2 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 EFC39071.1 - 0.00071 19.2 0.0 0.013 15.0 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 EFC39071.1 - 0.0013 18.6 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 EFC39071.1 - 0.0023 18.1 0.0 0.0039 17.3 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 EFC39071.1 - 0.045 12.8 0.0 0.27 10.3 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain ADH_zinc_N PF00107.26 EFC39071.1 - 0.17 11.8 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Lactamase_B PF00753.27 EFC39072.1 - 7.6e-05 22.8 0.0 0.00038 20.5 0.0 2.1 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily YL1 PF05764.13 EFC39072.1 - 0.21 11.7 0.4 0.35 10.9 0.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Zn-ribbon_8 PF09723.10 EFC39072.1 - 0.6 10.3 4.4 2.1 8.5 0.4 2.6 2 0 0 2 2 2 0 Zinc ribbon domain SGL PF08450.12 EFC39073.1 - 6.2e-21 75.1 0.0 7.6e-21 74.8 0.0 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EFC39073.1 - 1.9e-14 52.8 1.3 0.00083 19.3 0.0 5.5 6 1 0 6 6 6 3 NHL repeat SBBP PF06739.11 EFC39073.1 - 0.00085 19.3 0.6 0.0086 16.1 0.0 2.9 3 0 0 3 3 3 1 Beta-propeller repeat Str_synth PF03088.16 EFC39073.1 - 0.0031 17.6 0.1 0.099 12.8 0.0 3.2 2 2 1 3 3 3 1 Strictosidine synthase Penicil_amidase PF01804.18 EFC39075.1 - 8.5e-154 514.1 0.0 1.1e-153 513.8 0.0 1.0 1 0 0 1 1 1 1 Penicillin amidase DUF1634 PF07843.11 EFC39075.1 - 0.0019 18.2 1.3 0.0044 17.1 0.1 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1634) PFO_beta_C PF12367.8 EFC39075.1 - 0.047 13.8 0.1 0.71 10.0 0.0 2.6 2 0 0 2 2 2 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal DUF2721 PF11026.8 EFC39075.1 - 0.15 12.0 2.5 0.27 11.1 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) GWT1 PF06423.12 EFC39075.1 - 0.41 10.8 5.1 0.16 12.1 1.6 2.0 1 1 1 2 2 2 0 GWT1 Orf78 PF06024.12 EFC39075.1 - 0.6 10.4 10.5 0.41 11.0 0.5 2.9 1 1 2 3 3 3 0 Orf78 (ac78) DUF2207 PF09972.9 EFC39075.1 - 1.8 7.2 9.7 3 6.5 5.4 2.7 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) Synaptobrevin PF00957.21 EFC39075.1 - 4.8 7.0 6.2 4.4 7.2 0.1 3.4 3 0 0 3 3 3 0 Synaptobrevin DUF2828 PF11443.8 EFC39076.1 - 1.6e-148 495.7 1.2 2e-148 495.3 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) VWA_CoxE PF05762.14 EFC39076.1 - 0.071 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein ATG27 PF09451.10 EFC39078.1 - 1.2e-11 45.0 0.2 1.4e-11 44.7 0.2 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFC39078.1 - 1.5e-05 24.2 4.3 3.5e-05 23.0 4.3 1.5 1 1 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 EFC39078.1 - 0.00065 19.8 2.8 0.6 10.2 0.4 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat DUF4013 PF13197.6 EFC39078.1 - 0.0094 15.8 0.7 0.0094 15.8 0.7 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF4013) Pkinase PF00069.25 EFC39079.1 - 4.5e-26 91.8 0.1 6.8e-26 91.2 0.1 1.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39079.1 - 7.7e-18 64.7 0.0 9.1e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC39079.1 - 1.1e-05 24.5 0.0 1.5e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC39079.1 - 0.00067 18.7 0.0 0.0012 17.8 0.0 1.4 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFC39079.1 - 0.0097 15.9 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC39079.1 - 0.023 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFC39079.1 - 0.087 12.4 0.7 0.13 11.8 0.1 1.5 2 0 0 2 2 2 0 Choline/ethanolamine kinase SH PF01445.17 EFC39080.1 - 0.097 12.7 1.6 0.76 9.8 0.2 2.8 2 0 0 2 2 2 0 Viral small hydrophobic protein DUF2207 PF09972.9 EFC39080.1 - 3.8 6.2 17.8 20 3.8 0.1 3.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) SRA1 PF07304.11 EFC39081.1 - 0.032 14.0 0.6 0.3 10.9 0.0 2.6 2 1 0 2 2 2 0 Steroid receptor RNA activator (SRA1) LRR_6 PF13516.6 EFC39082.1 - 5.1e-25 85.4 27.2 0.0011 18.8 0.1 11.4 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.7 EFC39082.1 - 1.5e-14 53.9 45.2 0.00011 22.5 0.3 8.4 7 2 2 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39082.1 - 1.5e-09 37.4 35.4 0.013 15.3 2.1 8.5 4 4 5 9 9 9 7 Leucine rich repeat F-box PF00646.33 EFC39082.1 - 7.1e-06 25.8 0.4 4.9e-05 23.1 0.1 2.7 2 0 0 2 2 2 1 F-box domain LRR_1 PF00560.33 EFC39082.1 - 1.2e-05 25.2 23.0 20 6.2 0.0 10.5 11 1 0 11 11 11 1 Leucine Rich Repeat F-box-like PF12937.7 EFC39082.1 - 0.00019 21.2 1.1 0.00033 20.5 0.1 1.9 2 0 0 2 2 2 1 F-box-like zf-rbx1 PF12678.7 EFC39083.1 - 3.3e-08 33.7 0.7 3.3e-08 33.7 0.7 2.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFC39083.1 - 1.3e-07 31.8 1.8 1.3e-07 31.8 1.8 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC39083.1 - 1.9e-06 27.6 2.9 1.9e-06 27.6 2.9 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC39083.1 - 1.3e-05 25.1 1.2 1.3e-05 25.1 1.2 2.2 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFC39083.1 - 1.6e-05 24.7 0.4 1.6e-05 24.7 0.4 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFC39083.1 - 3.4e-05 23.6 7.6 4.4e-05 23.2 6.0 2.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC39083.1 - 0.00039 20.2 5.9 0.0007 19.4 0.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC39083.1 - 0.0007 19.6 0.2 0.0007 19.6 0.2 2.3 3 0 0 3 3 2 1 RING-type zinc-finger zf-RING_11 PF17123.5 EFC39083.1 - 0.0028 17.4 8.7 0.0077 16.0 0.4 3.0 3 0 0 3 3 3 2 RING-like zinc finger zf-ANAPC11 PF12861.7 EFC39083.1 - 0.0043 17.1 0.2 0.011 15.8 0.2 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger LepB_GAP_C PF18227.1 EFC39083.1 - 0.048 14.2 0.1 0.15 12.6 0.1 1.9 1 0 0 1 1 1 0 LepB GAP domain C-terminal subdomain zf-RING_4 PF14570.6 EFC39083.1 - 3.6 7.5 5.8 0.51 10.2 1.1 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 EFC39083.1 - 5 6.8 10.0 0.038 13.6 1.7 1.8 2 0 0 2 2 1 0 Zinc-ribbon, C4HC2 type SelR PF01641.18 EFC39086.1 - 7.8e-48 161.5 0.3 9.9e-48 161.2 0.3 1.1 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 EFC39086.1 - 0.00026 21.1 0.9 0.0016 18.6 0.9 2.1 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_10 PF10058.9 EFC39086.1 - 0.007 16.1 1.0 0.027 14.2 0.2 2.0 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein HECT_2 PF09814.9 EFC39086.1 - 0.11 11.4 0.6 2 7.2 0.6 2.1 1 1 0 1 1 1 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Lar_restr_allev PF14354.6 EFC39086.1 - 0.19 12.1 1.2 9.5 6.7 1.2 2.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-B_box PF00643.24 EFC39087.1 - 1.1e-06 28.6 4.2 1.1e-06 28.6 4.2 3.1 2 1 0 2 2 2 1 B-box zinc finger Golgin_A5 PF09787.9 EFC39087.1 - 0.0024 17.4 4.0 0.0034 16.9 4.0 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Apolipoprotein PF01442.18 EFC39087.1 - 0.12 12.2 1.9 0.18 11.7 1.9 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Nup54 PF13874.6 EFC39087.1 - 0.85 9.7 4.8 2.4 8.2 4.7 1.9 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 MUG113 PF13455.6 EFC39087.1 - 3.8 8.3 5.8 3.3 8.4 0.9 2.4 2 1 0 2 2 2 0 Meiotically up-regulated gene 113 TPT PF03151.16 EFC39088.1 - 2.6e-18 66.4 20.2 3e-11 43.2 4.0 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 EFC39088.1 - 1.4e-06 28.6 4.2 1.4e-06 28.6 4.2 3.9 3 1 0 3 3 3 1 EamA-like transporter family UAA PF08449.11 EFC39088.1 - 2.5e-05 23.6 24.4 0.00023 20.5 5.7 2.3 2 0 0 2 2 2 2 UAA transporter family PUNUT PF16913.5 EFC39088.1 - 0.00016 21.0 9.6 0.00016 21.0 9.6 2.4 2 1 0 2 2 2 2 Purine nucleobase transmembrane transport SUB1_ProdP9 PF18213.1 EFC39088.1 - 0.34 10.8 3.0 0.9 9.4 3.0 1.7 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 DUF2244 PF10003.9 EFC39088.1 - 6.9 6.3 6.8 13 5.5 1.8 2.7 2 0 0 2 2 2 0 Integral membrane protein (DUF2244) TM2 PF05154.16 EFC39089.1 - 5.4e-19 68.3 6.1 7.6e-19 67.8 6.1 1.2 1 0 0 1 1 1 1 TM2 domain DUF212 PF02681.14 EFC39090.1 - 0.063 13.4 0.9 0.1 12.7 0.9 1.3 1 0 0 1 1 1 0 Divergent PAP2 family Peptidase_C2 PF00648.21 EFC39091.1 - 3e-69 233.3 0.0 2.3e-68 230.4 0.0 2.1 2 0 0 2 2 2 1 Calpain family cysteine protease TPR_1 PF00515.28 EFC39091.1 - 1.7e-15 56.1 9.8 4.6e-05 23.1 0.0 8.0 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39091.1 - 1.1e-13 50.1 1.2 0.0014 18.6 0.0 7.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC39091.1 - 1.6e-11 43.5 8.1 0.0086 16.2 0.1 7.2 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC39091.1 - 2e-10 40.8 2.0 0.028 14.7 0.0 6.1 5 1 2 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC39091.1 - 6.4e-10 38.7 0.4 0.00074 19.7 0.0 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC39091.1 - 7.2e-08 32.0 4.4 0.11 12.2 0.0 5.9 5 2 1 6 6 6 2 TPR repeat TPR_9 PF13371.6 EFC39091.1 - 4.2e-07 30.0 0.0 0.011 15.8 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat Calpain_III PF01067.22 EFC39091.1 - 8.3e-07 29.4 0.1 9.9e-06 25.9 0.0 2.7 3 0 0 3 3 2 1 Calpain large subunit, domain III TPR_19 PF14559.6 EFC39091.1 - 1.1e-06 29.0 0.0 7.2e-05 23.2 0.0 3.8 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC39091.1 - 8e-05 23.2 0.0 0.63 11.0 0.0 4.6 4 1 1 5 5 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 EFC39091.1 - 0.00017 21.9 0.1 0.0017 18.7 0.1 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC39091.1 - 0.0026 18.3 0.1 3.5 8.5 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC39091.1 - 0.0047 16.3 0.2 6.2 6.4 0.0 3.4 3 0 0 3 3 3 1 SHNi-TPR DUF4437 PF14499.6 EFC39091.1 - 0.0094 15.1 0.0 0.63 9.1 0.0 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF4437) TPR_10 PF13374.6 EFC39091.1 - 0.011 15.6 0.3 3.1 7.8 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat CNOT11 PF10155.9 EFC39091.1 - 0.09 12.9 1.4 2.7 8.1 0.1 3.3 4 0 0 4 4 3 0 CCR4-NOT transcription complex subunit 11 MIT PF04212.18 EFC39091.1 - 0.1 12.7 2.6 5 7.3 0.1 4.3 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 EFC39091.1 - 0.12 13.0 0.0 28 5.5 0.0 3.6 2 1 0 3 3 3 0 Tetratricopeptide repeat PD40 PF07676.12 EFC39091.1 - 0.14 12.1 2.4 0.81 9.7 0.2 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF2263 PF10021.9 EFC39092.1 - 1.5e-25 90.3 0.0 3.3e-25 89.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) ERG4_ERG24 PF01222.17 EFC39093.1 - 1.8e-87 293.9 19.5 1.9e-87 293.8 19.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFC39093.1 - 0.0003 20.4 0.2 0.0013 18.3 0.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PI3K_rbd PF00794.18 EFC39094.1 - 0.047 13.8 2.7 0.087 13.0 0.1 2.4 2 1 0 2 2 2 0 PI3-kinase family, ras-binding domain DAPG_hydrolase PF18089.1 EFC39094.1 - 0.057 13.0 0.0 0.095 12.2 0.0 1.4 1 0 0 1 1 1 0 DAPG hydrolase PhiG domain HTH_Tnp_1 PF01527.20 EFC39094.1 - 0.087 13.1 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Transposase ESM4 PF15952.5 EFC39095.1 - 0.59 10.5 35.3 0.05 14.0 13.7 2.0 1 1 1 2 2 2 0 Enhancer of split M4 family Sin3a_C PF16879.5 EFC39095.1 - 2.1 8.0 20.7 2.5 7.7 20.7 1.0 1 0 0 1 1 1 0 C-terminal domain of Sin3a protein EGF_2 PF07974.13 EFC39096.1 - 4.6e-47 158.1 226.4 0.0001 22.6 10.2 12.4 12 0 0 12 12 12 12 EGF-like domain Bacteriocin_IId PF09221.10 EFC39096.1 - 0.00039 20.5 0.1 0.11 12.8 0.0 3.3 3 0 0 3 3 3 1 Bacteriocin class IId cyclical uberolysin-like RGS PF00615.19 EFC39096.1 - 0.0024 18.2 0.3 0.0067 16.7 0.3 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4413 PF14372.6 EFC39096.1 - 0.013 15.8 0.5 3.9 7.9 0.2 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4413) CelTOS PF18659.1 EFC39096.1 - 0.17 12.4 5.2 0.2 12.1 2.9 2.2 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Pkinase PF00069.25 EFC39097.1 - 6.2e-52 176.6 0.6 1.4e-51 175.4 0.1 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39097.1 - 3.1e-46 157.7 0.3 3.2e-39 134.8 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFC39097.1 - 0.0038 17.2 0.0 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC39097.1 - 0.026 13.8 0.0 0.065 12.5 0.0 1.6 1 0 0 1 1 1 0 Kinase-like Chlam_PMP PF02415.17 EFC39097.1 - 2.6 8.7 24.4 3.3 8.4 0.6 6.8 6 0 0 6 6 6 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Carb_anhydrase PF00194.21 EFC39098.1 - 4.6e-33 114.8 3.4 8.9e-32 110.6 3.4 2.0 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Sec7_N PF12783.7 EFC39099.1 - 0.0042 17.0 0.3 0.0093 15.9 0.3 1.6 1 1 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mito_carr PF00153.27 EFC39100.1 - 2.1e-30 104.5 3.4 5.7e-16 58.2 0.4 3.5 2 1 1 3 3 3 3 Mitochondrial carrier protein LRR_6 PF13516.6 EFC39101.1 - 1.2e-52 171.5 29.1 0.00011 21.9 0.0 14.3 14 0 0 14 14 14 11 Leucine Rich repeat LRR_8 PF13855.6 EFC39101.1 - 6e-40 134.8 44.6 6.5e-08 32.2 0.8 6.2 4 1 4 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC39101.1 - 7.7e-27 92.9 32.0 0.00017 21.9 0.1 8.3 2 2 5 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39101.1 - 9.3e-16 56.0 21.9 5.2 8.0 0.0 13.6 14 1 1 15 15 15 5 Leucine Rich Repeat LRR_9 PF14580.6 EFC39101.1 - 6.5e-09 35.5 7.3 0.00066 19.2 1.8 3.9 1 1 3 4 4 4 3 Leucine-rich repeat F-box-like PF12937.7 EFC39101.1 - 0.0012 18.7 1.9 0.0019 18.1 0.8 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC39101.1 - 0.0079 16.0 1.1 0.027 14.3 1.0 2.0 1 1 1 2 2 2 1 F-box domain LEA_2 PF03168.13 EFC39102.1 - 0.016 15.7 0.1 0.032 14.7 0.1 1.6 2 0 0 2 2 2 0 Late embryogenesis abundant protein PEP-utilizers_C PF02896.18 EFC39103.1 - 4.3e-88 295.2 0.1 6.8e-88 294.6 0.1 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 EFC39103.1 - 1.3e-58 198.9 0.1 1.3e-45 156.1 0.0 2.4 1 1 1 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain ADK PF00406.22 EFC39103.1 - 8.6e-49 165.5 0.0 3.2e-48 163.7 0.0 2.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFC39103.1 - 3.5e-34 118.2 0.2 2.7e-33 115.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain PEP-utilizers PF00391.23 EFC39103.1 - 8.1e-22 76.7 0.2 2e-21 75.5 0.2 1.7 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain AAA_18 PF13238.6 EFC39103.1 - 8.3e-10 39.3 0.0 3.5e-09 37.3 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC39103.1 - 4.2e-06 27.0 0.0 5.4e-05 23.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EFC39103.1 - 0.00082 19.1 1.2 0.46 10.1 0.0 3.0 2 0 0 2 2 2 2 Thymidylate kinase HpcH_HpaI PF03328.14 EFC39103.1 - 0.0066 15.6 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family HTH_48 PF17906.1 EFC39103.1 - 0.014 15.5 0.1 5.8 7.1 0.0 3.0 3 0 0 3 3 3 0 HTH domain in Mos1 transposase RB_A PF01858.17 EFC39103.1 - 0.036 13.9 2.4 0.1 12.4 0.3 2.5 2 0 0 2 2 2 0 Retinoblastoma-associated protein A domain DUF4142 PF13628.6 EFC39103.1 - 0.045 14.0 1.8 0.063 13.5 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) Cytidylate_kin PF02224.18 EFC39103.1 - 0.11 12.2 0.1 0.61 9.8 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase CE2_N PF17996.1 EFC39104.1 - 0.024 14.6 0.1 0.057 13.4 0.1 1.7 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal SAM_1 PF00536.30 EFC39104.1 - 0.057 13.9 1.1 0.23 11.9 0.0 2.7 4 1 0 4 4 4 0 SAM domain (Sterile alpha motif) AF-4 PF05110.13 EFC39105.1 - 0.15 10.1 75.5 0.09 10.9 0.5 2.4 2 0 0 2 2 2 0 AF-4 proto-oncoprotein SSP160 PF06933.11 EFC39105.1 - 1.7 6.8 15.1 0.15 10.2 9.3 2.1 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 zf-Nse PF11789.8 EFC39106.1 - 2.7e-14 52.7 0.0 5.5e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 EFC39106.1 - 0.0016 18.2 0.3 0.0031 17.2 0.3 1.6 1 1 0 1 1 1 1 MIZ/SP-RING zinc finger ORC6 PF05460.13 EFC39109.1 - 7 5.8 11.0 0.61 9.3 3.8 2.3 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) DUF4116 PF13475.6 EFC39111.1 - 1.4e-40 136.8 15.5 3.8e-09 36.1 0.1 7.7 3 3 5 8 8 8 8 Domain of unknown function (DUF4116) RNaseH_C PF09293.10 EFC39111.1 - 0.11 12.8 0.4 0.51 10.7 0.0 2.1 2 0 0 2 2 2 0 T4 RNase H, C terminal Zn_clus PF00172.18 EFC39112.1 - 6.1e-07 29.5 11.9 1.4e-06 28.3 11.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_2 PF07719.17 EFC39113.1 - 6e-06 26.0 1.1 0.13 12.4 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC39113.1 - 0.0022 17.7 6.5 0.27 11.1 0.0 4.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC39113.1 - 0.0035 17.5 0.0 0.064 13.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Cnn_1N PF07989.11 EFC39113.1 - 0.017 15.3 1.0 0.37 11.0 0.0 2.7 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 TPR_8 PF13181.6 EFC39113.1 - 0.017 15.3 10.3 4.9 7.6 0.6 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA_16 PF13191.6 EFC39113.1 - 0.087 13.2 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Gal-bind_lectin PF00337.22 EFC39113.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Galactoside-binding lectin TAL_FSA PF00923.19 EFC39114.1 - 1.3e-64 218.3 0.1 2.3e-64 217.5 0.1 1.4 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase EF-hand_1 PF00036.32 EFC39114.1 - 4e-12 44.7 4.4 1.9e-05 23.9 1.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC39114.1 - 1.5e-11 44.6 2.5 1.5e-11 44.6 2.5 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC39114.1 - 1.2e-09 37.3 1.4 0.00087 19.0 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFC39114.1 - 1.3e-08 34.5 2.6 8e-05 22.4 0.8 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC39114.1 - 9.6e-07 28.0 4.1 0.0061 16.0 0.6 2.7 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 EFC39114.1 - 0.00029 20.8 6.3 0.2 11.6 2.3 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF853 PF05872.12 EFC39114.1 - 0.0072 15.0 0.3 0.013 14.1 0.1 1.4 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF853) EF-hand_9 PF14658.6 EFC39114.1 - 0.026 14.8 0.3 0.13 12.6 0.2 2.3 2 1 0 2 2 2 0 EF-hand domain DUF1002 PF06207.11 EFC39114.1 - 1.8 8.0 7.9 0.11 12.0 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1002) Pkinase PF00069.25 EFC39115.1 - 1.7e-39 135.8 0.5 5.1e-39 134.2 0.5 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39115.1 - 3.6e-24 85.4 0.2 7.7e-24 84.4 0.2 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC39115.1 - 6.5e-09 35.1 2.5 1.8e-08 33.6 2.4 1.8 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC39115.1 - 0.029 14.3 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Lin-8 PF03353.15 EFC39115.1 - 2.1 7.9 10.1 0.37 10.3 6.0 1.8 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist OST3_OST6 PF04756.13 EFC39116.1 - 5.7e-14 52.2 11.7 5.7e-14 52.2 11.7 2.8 1 1 1 2 2 2 1 OST3 / OST6 family, transporter family SpoIIIAH PF12685.7 EFC39116.1 - 0.00041 20.3 0.5 0.00041 20.3 0.5 2.1 2 0 0 2 2 2 1 SpoIIIAH-like protein LptF_LptG PF03739.14 EFC39116.1 - 0.0019 17.1 0.0 0.47 9.3 0.0 2.3 2 0 0 2 2 2 2 Lipopolysaccharide export system permease LptF/LptG DUF2370 PF10176.9 EFC39116.1 - 0.0046 16.6 1.1 0.0046 16.6 1.1 2.5 3 0 0 3 3 2 1 Protein of unknown function (DUF2370) Connexin PF00029.19 EFC39116.1 - 0.0073 16.1 1.3 0.083 12.6 0.5 2.2 2 0 0 2 2 2 1 Connexin Ureide_permease PF07168.11 EFC39116.1 - 0.013 14.3 0.5 0.059 12.1 0.3 1.9 2 0 0 2 2 2 0 Ureide permease Kei1 PF08552.11 EFC39116.1 - 0.023 14.6 1.9 0.06 13.2 0.2 2.1 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 EOS1 PF12326.8 EFC39116.1 - 0.026 14.5 0.7 1.9 8.4 0.1 2.2 2 0 0 2 2 2 0 N-glycosylation protein DUF3464 PF11947.8 EFC39116.1 - 0.042 13.6 0.2 0.56 9.9 0.1 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF4337 PF14235.6 EFC39116.1 - 0.048 13.8 0.6 1.2 9.2 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Mpp10 PF04006.12 EFC39116.1 - 0.059 11.8 17.1 0.12 10.7 5.4 2.0 2 0 0 2 2 2 0 Mpp10 protein DUF4746 PF15928.5 EFC39116.1 - 0.22 10.9 7.2 0.11 11.8 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) ORC_WH_C PF18137.1 EFC39116.1 - 0.28 11.2 5.1 1.2 9.2 5.1 1.9 1 1 0 1 1 1 0 Origin recognition complex winged helix C-terminal DHHC PF01529.20 EFC39116.1 - 0.7 10.0 16.1 1.6 8.8 5.0 3.3 1 1 2 3 3 3 0 DHHC palmitoyltransferase HCO3_cotransp PF00955.21 EFC39116.1 - 2 7.1 19.9 0.09 11.6 6.7 2.1 1 1 0 2 2 2 0 HCO3- transporter family DUF4820 PF16091.5 EFC39116.1 - 2.6 7.4 8.5 0.34 10.2 3.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Peroxin-13_N PF04088.13 EFC39116.1 - 2.7 8.3 7.4 53 4.1 0.0 2.7 2 1 0 2 2 2 0 Peroxin 13, N-terminal region FAM176 PF14851.6 EFC39116.1 - 3.2 7.4 6.5 0.68 9.6 1.9 2.0 2 0 0 2 2 2 0 FAM176 family RP-C_C PF11800.8 EFC39116.1 - 4 7.5 5.1 6 6.9 1.0 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region Jak1_Phl PF17887.1 EFC39116.1 - 5.8 6.9 11.5 0.9 9.5 0.2 2.3 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain SPC12 PF06645.13 EFC39116.1 - 6.4 6.9 15.6 0.077 13.1 2.4 3.0 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Cellulose_synt PF03552.14 EFC39116.1 - 7.5 4.9 12.7 0.031 12.8 2.3 1.9 1 1 1 2 2 2 0 Cellulose synthase Shisa PF13908.6 EFC39116.1 - 8.4 6.6 8.7 8.9 6.5 1.9 3.2 1 1 2 3 3 3 0 Wnt and FGF inhibitory regulator DASH_Dad4 PF08650.10 EFC39117.1 - 0.011 15.6 2.6 1.3 9.1 0.0 3.1 2 0 0 2 2 2 0 DASH complex subunit Dad4 Vps52 PF04129.12 EFC39118.1 - 2.7e-96 323.4 33.7 3.9e-96 322.8 33.7 1.2 1 0 0 1 1 1 1 Vps52 / Sac2 family GIT_CC PF16559.5 EFC39118.1 - 0.026 14.4 2.5 0.19 11.6 2.5 2.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor V-SNARE PF05008.15 EFC39118.1 - 0.052 13.9 2.6 0.37 11.2 2.6 2.6 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus COG2 PF06148.11 EFC39118.1 - 0.15 12.2 7.9 0.14 12.3 4.3 2.8 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PRRSV_2b PF07069.11 EFC39118.1 - 0.39 11.3 1.5 8.6 6.9 0.4 2.6 2 0 0 2 2 2 0 Porcine reproductive and respiratory syndrome virus 2b Gly_radical PF01228.21 EFC39118.1 - 1.3 9.6 4.3 7.3 7.2 2.1 3.0 3 0 0 3 3 3 0 Glycine radical DUF1664 PF07889.12 EFC39118.1 - 1.5 8.8 8.6 0.82 9.7 1.6 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) STAR_dimer PF16544.5 EFC39118.1 - 1.8 8.2 5.8 0.63 9.7 0.1 3.4 3 1 1 4 4 4 0 Homodimerisation region of STAR domain protein DUF4208 PF13907.6 EFC39118.1 - 8.7 6.9 8.5 12 6.4 0.3 4.1 4 2 2 6 6 6 0 Domain of unknown function (DUF4208) E1-E2_ATPase PF00122.20 EFC39119.1 - 2e-17 63.3 0.0 2e-15 56.7 0.0 2.7 1 1 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFC39119.1 - 6.8e-07 29.3 1.2 3.3e-06 27.1 0.1 2.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC39119.1 - 0.022 15.1 0.0 0.16 12.2 0.0 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase LRRNT PF01462.18 EFC39119.1 - 0.16 11.7 0.8 0.62 9.8 0.4 2.2 2 0 0 2 2 2 0 Leucine rich repeat N-terminal domain Acetyltransf_1 PF00583.25 EFC39120.1 - 4.4e-14 52.7 0.0 5.5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC39120.1 - 1.5e-07 31.4 0.1 4e-07 30.0 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC39120.1 - 7.1e-07 29.6 0.1 1.9e-06 28.2 0.0 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC39120.1 - 0.023 14.8 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EFC39120.1 - 0.031 13.8 0.3 0.042 13.3 0.3 1.4 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_4 PF13420.7 EFC39120.1 - 0.039 14.1 0.2 0.077 13.1 0.2 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFC39120.1 - 0.051 13.3 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rieske PF00355.26 EFC39121.1 - 1.4e-20 73.0 0.0 2.9e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain PaO PF08417.12 EFC39121.1 - 8.8e-12 45.0 0.0 1.9e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Pheophorbide a oxygenase Ring_hydroxyl_A PF00848.19 EFC39121.1 - 0.0045 17.0 0.0 0.18 11.7 0.0 2.3 2 0 0 2 2 2 1 Ring hydroxylating alpha subunit (catalytic domain) BTB PF00651.31 EFC39123.1 - 2.1e-24 85.9 5.7 7.1e-16 58.4 0.2 3.0 2 1 1 3 3 3 2 BTB/POZ domain DUF3342 PF11822.8 EFC39123.1 - 0.0016 18.6 1.0 0.0035 17.5 0.2 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) MgtE_N PF03448.17 EFC39123.1 - 0.047 14.3 2.7 3 8.5 0.0 3.2 3 1 0 3 3 3 0 MgtE intracellular N domain EcsC PF12787.7 EFC39123.1 - 0.062 13.0 2.4 0.095 12.4 0.1 2.1 2 1 0 2 2 2 0 EcsC protein family DUF3219 PF11514.8 EFC39123.1 - 1.6 8.8 6.7 2.5 8.2 0.1 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF3219) PrsW-protease PF13367.6 EFC39124.1 - 2.3e-09 37.0 11.5 7.1e-09 35.4 7.9 2.7 2 1 1 3 3 3 1 PrsW family intramembrane metalloprotease Ribosomal_L22 PF00237.19 EFC39125.1 - 5.5e-35 119.7 0.4 8.6e-35 119.1 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e FlaA PF04620.12 EFC39125.1 - 0.12 12.0 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Flagellar filament outer layer protein Flaa ABC_membrane PF00664.23 EFC39126.1 - 1.3e-53 182.5 14.2 1.9e-53 181.9 14.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC39126.1 - 3.8e-32 111.7 0.0 1.1e-31 110.2 0.0 1.9 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC39126.1 - 2.2e-07 30.5 1.6 0.00014 21.4 0.0 2.9 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC39126.1 - 0.00055 19.6 0.0 0.0013 18.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC39126.1 - 0.00064 19.5 0.0 0.0027 17.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC39126.1 - 0.00071 20.0 0.7 0.0028 18.1 0.7 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EFC39126.1 - 0.0016 18.2 1.1 0.0039 16.9 0.0 2.1 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFC39126.1 - 0.0029 17.9 0.0 0.0087 16.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC39126.1 - 0.0076 16.2 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 EFC39126.1 - 0.022 15.2 0.3 1.9 8.9 0.3 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 EFC39126.1 - 0.035 13.9 0.0 0.71 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EFC39126.1 - 0.036 14.1 0.2 0.24 11.4 0.0 2.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EFC39126.1 - 0.047 12.5 0.0 0.092 11.5 0.0 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_18 PF13238.6 EFC39126.1 - 0.082 13.5 0.0 0.25 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC39126.1 - 0.12 11.9 0.1 0.38 10.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EFC39126.1 - 0.15 11.3 0.0 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin Mlh1_C PF16413.5 EFC39127.1 - 1e-56 192.3 9.2 9.2e-56 189.2 2.1 3.1 2 2 0 2 2 2 1 DNA mismatch repair protein Mlh1 C-terminus HATPase_c_3 PF13589.6 EFC39127.1 - 8e-13 48.4 0.0 3e-12 46.5 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 EFC39127.1 - 2.6e-06 27.1 2.6 0.0011 18.7 0.4 2.6 1 1 1 2 2 2 2 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 EFC39127.1 - 2.1e-05 25.0 0.0 5.7e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase AAA_22 PF13401.6 EFC39128.1 - 0.0028 17.9 0.0 0.019 15.3 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC39128.1 - 0.012 16.0 0.0 0.054 13.9 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain HHH_3 PF12836.7 EFC39128.1 - 0.023 14.9 0.0 0.069 13.4 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif AAA_19 PF13245.6 EFC39128.1 - 0.075 13.4 0.0 0.2 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain KilA-N PF04383.13 EFC39128.1 - 0.23 11.3 1.9 0.4 10.6 0.7 2.1 2 1 0 2 2 2 0 KilA-N domain ATP-synt_C PF00137.21 EFC39129.1 - 6.4e-29 100.1 31.3 7.1e-19 67.9 11.0 2.2 2 0 0 2 2 2 2 ATP synthase subunit C EMP24_GP25L PF01105.24 EFC39130.1 - 4.8e-23 82.0 0.1 5.2e-23 81.9 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MIF4G PF02854.19 EFC39131.1 - 8.1e-44 149.8 9.8 8.1e-44 149.8 9.8 3.3 3 0 0 3 3 3 2 MIF4G domain TFIIA PF03153.13 EFC39131.1 - 0.057 13.4 31.8 0.012 15.6 17.7 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit OsmC PF02566.19 EFC39132.1 - 1e-15 58.0 0.0 1.8e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 OsmC-like protein META PF03724.16 EFC39132.1 - 0.017 15.1 0.3 0.49 10.4 0.1 2.1 1 1 1 2 2 2 0 META domain MukF_M PF17192.4 EFC39133.1 - 0.069 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 MukF middle domain DUF1479 PF07350.12 EFC39135.1 - 5.1e-11 42.0 0.1 0.00014 20.8 0.1 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 EFC39135.1 - 0.00027 21.3 0.0 1.3 9.3 0.0 3.1 3 0 0 3 3 3 2 Phytanoyl-CoA dioxygenase (PhyH) UBA_6 PF18039.1 EFC39135.1 - 0.026 14.5 0.3 0.17 11.8 0.1 2.5 2 1 0 2 2 2 0 UBA-like domain DUF2097 PF09870.9 EFC39135.1 - 0.036 14.3 0.5 0.083 13.1 0.5 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2097) MCRA PF06100.11 EFC39135.1 - 0.098 11.4 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 MCRA family Peptidase_M16 PF00675.20 EFC39136.1 - 2.1e-17 63.5 1.1 6.3e-17 61.9 1.1 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFC39136.1 - 1.8e-14 54.2 2.3 5.3e-11 42.9 0.1 3.5 3 0 0 3 3 3 2 Peptidase M16 inactive domain TLD PF07534.16 EFC39137.1 - 8.5e-11 42.2 2.2 8.8e-11 42.2 0.4 2.0 2 1 0 2 2 2 1 TLD DUF4773 PF15998.5 EFC39139.1 - 0.0067 17.0 0.1 0.01 16.4 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4773) HRXXH PF13933.6 EFC39139.1 - 0.033 13.7 0.1 0.051 13.1 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family BAR_3 PF16746.5 EFC39141.1 - 0.021 14.5 0.2 0.049 13.3 0.2 1.6 1 1 0 1 1 1 0 BAR domain of APPL family DUF4116 PF13475.6 EFC39142.1 - 1.2e-18 66.5 5.0 3.5e-05 23.5 0.0 4.9 1 1 3 5 5 5 5 Domain of unknown function (DUF4116) Pkinase_Tyr PF07714.17 EFC39142.1 - 2.2e-06 27.2 3.1 4.1e-06 26.3 0.5 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFC39142.1 - 3.2e-06 26.7 0.6 3.2e-06 26.7 0.6 3.0 3 0 0 3 3 3 1 Protein kinase domain CIDR1_gamma PF18562.1 EFC39142.1 - 2.2 8.4 11.3 4.6 7.4 0.4 3.9 4 0 0 4 4 4 0 Cysteine-Rich Interdomain Region 1 gamma IF-2B PF01008.17 EFC39143.1 - 1.1e-50 172.4 0.0 1.3e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Catalase_C PF18011.1 EFC39143.1 - 0.056 13.1 0.0 0.12 12.0 0.0 1.6 1 1 0 1 1 1 0 C-terminal domain found in long catalases SH3_9 PF14604.6 EFC39144.1 - 0.12 12.2 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Copine PF07002.16 EFC39145.1 - 1.6e-52 178.1 0.2 6.4e-52 176.2 0.2 1.9 1 1 0 1 1 1 1 Copine C2 PF00168.30 EFC39145.1 - 3.7e-19 68.9 0.1 6.8e-09 36.0 0.0 2.7 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFC39145.1 - 0.00081 19.5 0.0 0.0019 18.4 0.0 1.6 1 1 0 1 1 1 1 vWA found in TerF C terminus Pro_isomerase PF00160.21 EFC39146.1 - 5.1e-50 169.8 2.2 5.1e-50 169.8 0.1 2.1 3 0 0 3 3 3 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ANAPC4_WD40 PF12894.7 EFC39146.1 - 7.3e-05 23.0 0.0 0.0096 16.2 0.0 3.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC39146.1 - 0.001 19.8 2.7 31 5.7 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat SR-25 PF10500.9 EFC39146.1 - 0.0024 17.5 14.3 0.0024 17.5 14.3 2.6 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein NHL PF01436.21 EFC39147.1 - 4.8e-35 117.8 11.1 1.6e-09 37.3 0.1 6.3 6 0 0 6 6 6 5 NHL repeat DUF5128 PF17170.4 EFC39147.1 - 2e-19 69.9 12.6 1.3e-09 37.7 0.1 3.8 1 1 3 4 4 4 4 6-bladed beta-propeller SGL PF08450.12 EFC39147.1 - 1.6e-12 47.6 0.1 2.1e-10 40.6 0.1 3.7 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC39147.1 - 3e-08 33.8 0.6 0.0074 16.5 0.0 4.9 4 1 1 5 5 5 1 Arylesterase DUF4934 PF16288.5 EFC39147.1 - 4.8e-06 26.4 0.5 0.044 13.7 0.0 3.2 3 1 0 3 3 3 2 Domain of unknown function (DUF4934) TolB_like PF15869.5 EFC39147.1 - 2.4e-05 23.7 0.1 0.015 14.5 0.0 2.9 2 1 2 4 4 4 2 TolB-like 6-blade propeller-like m04gp34like PF12216.8 EFC39147.1 - 0.001 18.7 0.4 6.3 6.3 0.0 3.1 3 0 0 3 3 3 2 Immune evasion protein He_PIG PF05345.12 EFC39147.1 - 0.0025 18.0 0.3 10 6.4 0.0 4.0 4 0 0 4 4 4 1 Putative Ig domain Str_synth PF03088.16 EFC39147.1 - 0.008 16.3 1.4 2.1 8.5 0.0 3.9 5 0 0 5 5 5 1 Strictosidine synthase SBBP PF06739.11 EFC39147.1 - 0.031 14.3 1.4 1.7 8.7 0.0 3.4 3 0 0 3 3 3 0 Beta-propeller repeat Phytase-like PF13449.6 EFC39147.1 - 0.032 14.2 0.0 15 5.4 0.0 3.0 2 1 1 3 3 3 0 Esterase-like activity of phytase DUF839 PF05787.13 EFC39147.1 - 0.11 11.6 0.1 8 5.5 0.1 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF839) CDP-OH_P_transf PF01066.21 EFC39148.1 - 2.2e-15 57.2 0.6 2.2e-15 57.2 0.6 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF4448 PF14610.6 EFC39148.1 - 0.18 11.6 0.5 0.56 9.9 0.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) DUF4240 PF14024.6 EFC39149.1 - 0.00014 22.0 0.7 0.00042 20.5 0.7 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF4240) F-box-like PF12937.7 EFC39149.1 - 0.00049 19.9 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC39149.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 F-box domain Trp_dioxygenase PF03301.13 EFC39150.1 - 9.6e-60 202.7 7.5 5.8e-38 131.1 2.2 2.2 2 0 0 2 2 2 2 Tryptophan 2,3-dioxygenase Gp_UL130 PF11668.8 EFC39150.1 - 0.12 12.3 0.0 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 HCMV glycoprotein pUL130 Pkinase PF00069.25 EFC39151.1 - 9.4e-64 215.3 0.2 1.2e-63 214.9 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39151.1 - 5.7e-38 130.7 0.0 8.4e-38 130.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC39151.1 - 3.2e-05 22.9 0.0 4.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC39151.1 - 0.048 13.0 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC39151.1 - 0.067 13.1 0.0 0.099 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RICH PF05062.12 EFC39151.1 - 0.44 10.9 4.0 2.2 8.7 0.4 2.5 2 0 0 2 2 2 0 RICH domain Rad50_zn_hook PF04423.14 EFC39152.1 - 0.00062 19.5 0.2 0.0017 18.1 0.2 1.7 1 0 0 1 1 1 1 Rad50 zinc hook motif CCDC24 PF15669.5 EFC39152.1 - 2.5 7.9 8.2 0.23 11.3 3.7 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family LCAT PF02450.15 EFC39153.1 - 2.6e-17 63.1 0.2 3.7e-17 62.6 0.2 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 EFC39153.1 - 2.2e-08 34.1 0.1 1.9e-06 27.8 0.0 2.5 3 0 0 3 3 3 1 PGAP1-like protein DUF900 PF05990.12 EFC39153.1 - 0.0022 17.5 0.0 0.0037 16.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Lipase_2 PF01674.18 EFC39153.1 - 0.0036 16.8 0.9 0.0073 15.8 0.3 1.8 2 0 0 2 2 2 1 Lipase (class 2) DUF676 PF05057.14 EFC39153.1 - 0.085 12.3 0.1 0.16 11.5 0.1 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Nodulin_late PF07127.11 EFC39153.1 - 0.21 11.9 0.2 0.21 11.9 0.2 2.2 2 0 0 2 2 2 0 Late nodulin protein BEN PF10523.9 EFC39154.1 - 0.055 13.7 0.1 0.3 11.3 0.0 2.2 2 0 0 2 2 2 0 BEN domain AAA_assoc_2 PF16193.5 EFC39154.1 - 0.2 12.0 0.9 2.5 8.5 0.6 2.7 1 1 1 2 2 2 0 AAA C-terminal domain LMBR1 PF04791.16 EFC39155.1 - 0.49 9.3 2.8 0.28 10.1 0.6 1.6 2 0 0 2 2 2 0 LMBR1-like membrane protein Palm_thioest PF02089.15 EFC39157.1 - 1.1e-56 192.4 1.9 1.2e-56 192.2 1.9 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 EFC39157.1 - 4.1e-05 23.0 0.0 8.2e-05 22.0 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC39157.1 - 0.00014 21.6 0.0 0.00021 21.0 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 EFC39157.1 - 0.00083 18.8 0.3 0.0016 17.9 0.1 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 EFC39157.1 - 0.0088 16.7 0.0 0.012 16.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family SLAC1 PF03595.17 EFC39158.1 - 0.005 16.2 4.9 0.015 14.6 0.1 2.5 2 0 0 2 2 2 1 Voltage-dependent anion channel DUF5337 PF17272.2 EFC39158.1 - 0.032 14.1 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5337) Y_Y_Y PF07495.13 EFC39158.1 - 6.3 6.8 11.8 0.26 11.3 1.5 3.5 3 0 0 3 3 3 0 Y_Y_Y domain G-alpha PF00503.20 EFC39160.1 - 1.2e-17 64.2 16.9 7.7e-09 35.2 0.9 4.6 4 2 0 4 4 4 4 G-protein alpha subunit TniB PF05621.11 EFC39160.1 - 0.13 11.6 0.7 2.1 7.7 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein PDZ_assoc PF10600.9 EFC39160.1 - 1.2 10.0 7.8 0.15 12.9 1.6 2.8 2 0 0 2 2 2 0 PDZ-associated domain of NMDA receptors CBP_BcsQ PF06564.12 EFC39162.1 - 0.012 15.1 3.5 0.012 15.1 3.5 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ DUF4200 PF13863.6 EFC39162.1 - 1.8 9.0 37.9 9.4 6.7 6.5 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) MHC2-interact PF09307.10 EFC39162.1 - 4.6 7.3 8.5 4.7 7.3 3.7 2.7 2 0 0 2 2 2 0 CLIP, MHC2 interacting MerR-DNA-bind PF09278.11 EFC39162.1 - 4.9 7.8 9.9 20 5.8 3.0 3.0 2 0 0 2 2 2 0 MerR, DNA binding DUF4407 PF14362.6 EFC39162.1 - 5.3 6.3 19.9 3.5 6.9 10.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 EFC39162.1 - 7.4 7.1 28.9 0.82 10.2 15.5 3.3 1 1 1 3 3 3 0 Protein of unknown function DUF16 DUF4116 PF13475.6 EFC39163.1 - 1.5e-16 59.8 5.7 1.7e-06 27.7 0.0 5.0 3 1 3 6 6 6 4 Domain of unknown function (DUF4116) B9-C2 PF07162.11 EFC39164.1 - 1.1e-38 133.1 0.1 1.4e-38 132.7 0.1 1.1 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein ELO PF01151.18 EFC39165.1 - 2.6e-55 187.7 20.7 3.1e-55 187.4 20.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family PspB PF06667.12 EFC39165.1 - 0.37 10.9 2.3 2.9 8.0 0.0 2.7 2 0 0 2 2 2 0 Phage shock protein B LRR_6 PF13516.6 EFC39167.1 - 2.7e-05 23.9 2.2 3.5 7.9 0.1 5.1 5 0 0 5 5 5 2 Leucine Rich repeat PriX PF18689.1 EFC39167.1 - 0.023 15.0 0.1 6.2 7.2 0.0 3.2 3 1 0 3 3 3 0 Primase X LRR_4 PF12799.7 EFC39167.1 - 0.15 12.5 15.1 1.2 9.6 0.2 4.6 4 1 2 6 6 6 0 Leucine Rich repeats (2 copies) Zn_clus PF00172.18 EFC39168.1 - 1.6e-07 31.3 16.8 3.6e-07 30.2 16.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_2 PF12796.7 EFC39169.1 - 7.8e-15 55.2 0.1 3.8e-14 53.0 0.1 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC39169.1 - 5.3e-12 44.8 0.2 1.9e-05 24.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EFC39169.1 - 7.6e-10 38.8 0.2 0.00083 19.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFC39169.1 - 1.7e-09 37.7 0.0 0.0014 18.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC39169.1 - 4.2e-09 36.8 0.0 0.0042 17.6 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) DnaA_N PF11638.8 EFC39169.1 - 0.02 14.6 1.6 7.9 6.3 0.0 3.5 4 0 0 4 4 4 0 DnaA N-terminal domain Paramyxo_ncap PF00973.19 EFC39169.1 - 0.11 11.4 7.1 0.16 10.9 7.1 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DDHD PF02862.17 EFC39169.1 - 0.21 11.7 4.0 0.28 11.3 4.0 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EFC39169.1 - 4.8 5.8 11.1 6 5.5 11.1 1.1 1 0 0 1 1 1 0 Presenilin RasGEF PF00617.19 EFC39172.1 - 1.3e-31 110.2 7.8 1e-30 107.3 1.4 3.1 2 0 0 2 2 2 2 RasGEF domain DOCK-C2 PF14429.6 EFC39172.1 - 1.5e-26 93.4 1.0 1.5e-26 93.4 1.0 2.6 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC39172.1 - 0.0028 17.8 0.9 0.0028 17.8 0.9 4.8 7 0 0 7 7 7 1 RasGEF N-terminal motif p450 PF00067.22 EFC39173.1 - 2.6e-61 207.8 0.1 3.3e-61 207.5 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 G-alpha PF00503.20 EFC39174.1 - 5.1e-40 137.7 12.0 6.8e-40 137.3 12.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC39174.1 - 0.00011 21.7 1.2 0.019 14.5 0.1 2.9 2 1 1 3 3 3 2 ADP-ribosylation factor family GDA1_CD39 PF01150.17 EFC39174.1 - 0.005 15.6 0.2 0.55 8.8 0.0 2.2 2 0 0 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family ASXH PF13919.6 EFC39174.1 - 0.043 13.8 0.0 0.17 11.9 0.0 1.9 2 0 0 2 2 2 0 Asx homology domain DUF1623 PF07785.11 EFC39174.1 - 0.043 14.0 0.9 5.8 7.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1623) Plavaka PF18759.1 EFC39175.1 - 0.0049 16.1 2.2 0.1 11.8 2.2 2.2 1 1 0 1 1 1 1 Plavaka transposase Thioredoxin_4 PF13462.6 EFC39177.1 - 5.3e-07 29.9 0.0 9.2e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Nitroreductase PF00881.24 EFC39178.1 - 1.2e-05 25.5 0.0 0.0079 16.3 0.0 3.0 3 1 0 3 3 3 2 Nitroreductase family DUF1186 PF06685.11 EFC39180.1 - 0.011 15.1 0.4 0.015 14.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1186) Mod_r PF07200.13 EFC39180.1 - 0.39 10.8 9.9 15 5.7 9.9 2.3 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Adap_comp_sub PF00928.21 EFC39181.1 - 8.9e-84 281.0 0.2 1.1e-83 280.7 0.2 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFC39181.1 - 5.4e-06 26.4 0.6 1.1e-05 25.4 0.3 1.7 2 0 0 2 2 2 1 Clathrin adaptor complex small chain Longin PF13774.6 EFC39181.1 - 0.0027 17.7 0.4 0.0071 16.4 0.4 1.7 1 0 0 1 1 1 1 Regulated-SNARE-like domain GTP_EFTU PF00009.27 EFC39184.1 - 2.9e-29 102.0 0.0 4.6e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC39184.1 - 7.7e-19 68.1 0.0 1.5e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC39184.1 - 1.6e-10 41.2 1.4 4e-10 39.9 1.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Gtr1_RagA PF04670.12 EFC39184.1 - 1.4e-05 24.6 0.0 2.9e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC39184.1 - 0.00022 21.3 0.3 0.0019 18.3 0.3 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EFC39184.1 - 0.0012 18.7 0.6 0.0033 17.3 0.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 4 NTPase_1 PF03266.15 EFC39184.1 - 0.0065 16.4 0.2 0.012 15.6 0.2 1.4 1 0 0 1 1 1 1 NTPase AAA_33 PF13671.6 EFC39184.1 - 0.015 15.4 0.0 0.032 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFC39184.1 - 0.11 12.4 0.2 9.6 6.1 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase Erf4 PF10256.9 EFC39185.1 - 0.00031 20.8 0.4 0.0012 18.9 0.0 2.2 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family G-alpha PF00503.20 EFC39186.1 - 7.4e-100 334.5 13.7 9.1e-100 334.3 13.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC39186.1 - 8.4e-11 41.6 3.5 4.2e-08 32.9 0.5 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC39186.1 - 6.2e-05 22.5 3.8 0.11 11.8 1.2 2.4 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC39186.1 - 0.00014 21.9 0.1 0.073 13.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Roc PF08477.13 EFC39186.1 - 0.0024 18.1 2.5 0.62 10.3 0.0 2.9 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EFC39186.1 - 0.0052 17.3 0.3 0.0097 16.4 0.3 1.8 1 1 0 1 1 1 1 ABC transporter Nop PF01798.18 EFC39186.1 - 0.018 14.5 0.3 0.039 13.4 0.1 1.8 2 0 0 2 2 2 0 snoRNA binding domain, fibrillarin AAA_29 PF13555.6 EFC39186.1 - 0.043 13.6 0.1 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CLASP_N PF12348.8 EFC39187.1 - 0.054 13.0 1.6 0.091 12.3 1.6 1.3 1 0 0 1 1 1 0 CLASP N terminal HOOK PF05622.12 EFC39189.1 - 0.23 9.6 0.0 0.35 9.0 0.0 1.2 1 0 0 1 1 1 0 HOOK protein HEAT PF02985.22 EFC39191.1 - 5.1e-06 26.3 0.4 10 6.7 0.0 6.5 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 EFC39191.1 - 1.9e-05 25.1 0.7 15 6.2 0.0 6.6 7 0 0 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 EFC39191.1 - 0.00071 19.9 0.1 67 4.0 0.0 6.3 6 1 0 6 6 6 0 HEAT repeats Vac14_Fab1_bd PF12755.7 EFC39191.1 - 0.0056 17.3 0.6 1 10.0 0.0 5.1 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region RYDR_ITPR PF01365.21 EFC39191.1 - 0.031 13.7 3.9 0.17 11.3 0.1 3.7 4 0 0 4 4 4 0 RIH domain CcmH PF03918.14 EFC39191.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein Cnd1 PF12717.7 EFC39191.1 - 0.14 12.2 11.3 0.77 9.8 0.4 5.3 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 IF4E PF01652.18 EFC39192.1 - 6.7e-50 169.0 0.1 1e-49 168.4 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Ndc1_Nup PF09531.10 EFC39192.1 - 0.27 9.9 3.6 0.29 9.8 3.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EFC39192.1 - 0.38 9.3 6.7 0.34 9.4 6.7 1.2 1 0 0 1 1 1 0 Macoilin family SAGA-Tad1 PF12767.7 EFC39192.1 - 3.5 7.3 17.0 60 3.3 17.0 2.0 1 1 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Dicty_REP PF05086.12 EFC39192.1 - 4.3 5.2 15.4 6.3 4.6 15.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Snapin_Pallidin PF14712.6 EFC39193.1 - 0.029 14.8 3.0 0.029 14.8 3.0 2.9 1 1 0 2 2 2 0 Snapin/Pallidin MtrB PF05440.12 EFC39193.1 - 0.12 12.8 2.5 17 5.9 0.1 3.8 3 1 1 4 4 4 0 Tetrahydromethanopterin S-methyltransferase subunit B MORN PF02493.20 EFC39193.1 - 0.18 11.7 1.0 0.29 11.1 0.1 1.8 2 0 0 2 2 2 0 MORN repeat DUF4164 PF13747.6 EFC39193.1 - 0.36 11.2 9.7 0.48 10.7 2.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) Cytochrom_B562 PF07361.11 EFC39193.1 - 0.39 11.4 8.6 1.4 9.7 8.6 2.0 1 0 0 1 1 1 0 Cytochrome b562 Apolipoprotein PF01442.18 EFC39193.1 - 0.75 9.6 15.5 1.9 8.3 15.5 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 EFC39193.1 - 0.84 9.7 12.7 0.97 9.5 5.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SAP PF02037.27 EFC39194.1 - 3.8e-06 26.5 0.4 0.00062 19.5 0.5 2.5 2 0 0 2 2 2 2 SAP domain SAM_3 PF18016.1 EFC39195.1 - 0.023 14.5 0.1 0.073 12.9 0.1 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Thiolase_N PF00108.23 EFC39196.1 - 2.7e-67 226.9 0.1 6.2e-67 225.7 0.1 1.6 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFC39196.1 - 1.7e-35 121.3 0.0 5e-35 119.8 0.0 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFC39196.1 - 7.9e-05 22.3 0.1 0.0002 21.1 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain FAE1_CUT1_RppA PF08392.12 EFC39196.1 - 0.18 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 FAE1/Type III polyketide synthase-like protein Pro_isomerase PF00160.21 EFC39197.1 - 7.6e-38 130.3 0.0 1.1e-37 129.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_C2 PF00648.21 EFC39198.1 - 3e-34 118.4 0.0 5.1e-34 117.6 0.0 1.4 1 0 0 1 1 1 1 Calpain family cysteine protease Sec16_C PF12931.7 EFC39198.1 - 0.06 13.0 0.1 0.14 11.8 0.1 1.5 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 DUF2369 PF10179.9 EFC39198.1 - 0.22 11.9 2.3 7.5 7.0 0.0 3.7 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) SARAF PF06682.12 EFC39199.1 - 8.1e-46 157.2 13.4 3.8e-45 155.0 13.4 1.8 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis RCR PF12273.8 EFC39199.1 - 0.11 13.1 11.7 0.077 13.7 3.9 2.9 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red DUF2530 PF10745.9 EFC39199.1 - 0.2 11.9 0.1 1.9 8.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) DUF5518 PF17647.1 EFC39199.1 - 0.23 11.6 0.1 0.23 11.6 0.1 2.2 3 0 0 3 3 3 0 Family of unknown function (DUF5518) Lipase_3 PF01764.25 EFC39200.1 - 0.083 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 3) LRR_6 PF13516.6 EFC39201.1 - 3.5e-45 148.2 34.5 0.0003 20.6 0.2 14.7 15 0 0 15 15 15 12 Leucine Rich repeat LRR_8 PF13855.6 EFC39201.1 - 8.2e-34 115.2 26.8 8.3e-08 31.9 3.4 6.7 2 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC39201.1 - 3.1e-27 94.2 34.3 0.0016 18.8 0.1 9.1 4 3 5 10 10 10 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39201.1 - 6.1e-20 68.7 6.6 7.1 7.6 0.0 12.9 14 0 0 14 14 14 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC39201.1 - 3.5e-06 26.6 1.8 0.7 9.4 0.1 4.1 1 1 2 5 5 5 4 Leucine-rich repeat DUF424 PF04242.13 EFC39201.1 - 0.41 10.9 3.0 1.3 9.3 0.1 3.2 3 2 1 4 4 4 0 Protein of unknown function (DUF424) TM2 PF05154.16 EFC39202.1 - 1.5e-13 50.8 9.8 2.1e-13 50.4 9.8 1.2 1 0 0 1 1 1 1 TM2 domain C2 PF00168.30 EFC39203.1 - 0.0022 18.3 0.2 0.0054 17.0 0.3 1.6 2 0 0 2 2 2 1 C2 domain PARG_cat PF05028.14 EFC39204.1 - 7.8e-75 252.2 2.7 1.1e-74 251.7 2.7 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) 14-3-3 PF00244.20 EFC39205.1 - 8.6e-38 130.0 0.1 1.1e-37 129.8 0.1 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF4771 PF15995.5 EFC39208.1 - 0.028 14.7 3.1 0.14 12.4 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4771) Guanylate_cyc PF00211.20 EFC39209.1 - 1.2e-25 90.2 0.1 3.2e-25 88.8 0.1 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 EFC39209.1 - 1.3e-24 87.4 0.0 4.3e-24 85.8 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain Pkinase PF00069.25 EFC39209.1 - 3.6e-22 79.0 0.0 1.8e-21 76.7 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39209.1 - 6.1e-12 45.4 0.0 2.5e-11 43.3 0.0 2.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC39209.1 - 0.0016 17.8 0.0 0.0039 16.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NB-ARC PF00931.22 EFC39209.1 - 0.0099 15.1 0.0 0.049 12.8 0.0 2.2 1 1 0 1 1 1 1 NB-ARC domain SpoVT_C PF15714.5 EFC39209.1 - 0.025 14.6 0.1 0.15 12.1 0.0 2.3 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor TniB PF05621.11 EFC39209.1 - 0.05 13.0 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Phostensin PF13914.6 EFC39209.1 - 0.07 13.8 0.0 0.2 12.3 0.0 1.7 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region Zeta_toxin PF06414.12 EFC39209.1 - 0.12 11.6 0.0 0.36 10.1 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin GAF PF01590.26 EFC39209.1 - 0.15 12.7 0.0 0.38 11.4 0.0 1.7 1 0 0 1 1 1 0 GAF domain LRR_8 PF13855.6 EFC39210.1 - 2.8e-32 110.3 46.9 1.2e-06 28.1 4.5 7.1 3 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC39210.1 - 3.1e-26 91.0 59.0 1.1e-05 25.7 6.3 9.5 6 2 4 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39210.1 - 4.6e-05 23.4 49.2 0.94 10.3 1.8 12.6 11 3 0 11 11 11 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC39210.1 - 0.00011 21.8 20.7 0.014 14.9 1.1 4.3 2 1 3 5 5 5 3 Leucine-rich repeat AT_hook PF02178.19 EFC39211.1 - 0.039 13.8 3.4 0.072 13.0 3.4 1.5 1 0 0 1 1 1 0 AT hook motif Pyridoxal_deC PF00282.19 EFC39212.1 - 1.4e-22 80.0 0.0 3.8e-22 78.5 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain LRRNT_2 PF08263.12 EFC39215.1 - 0.001 19.3 0.1 0.0026 18.0 0.1 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 EFC39215.1 - 0.0099 15.6 0.2 0.14 11.9 0.2 2.1 1 1 1 2 2 2 2 Leucine rich repeat Zn_clus PF00172.18 EFC39216.1 - 1.2e-07 31.7 16.2 1.2e-07 31.7 16.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IMUP PF15761.5 EFC39216.1 - 0.0067 17.1 7.1 0.018 15.8 7.1 1.6 1 0 0 1 1 1 1 Immortalisation up-regulated protein SR-25 PF10500.9 EFC39216.1 - 0.71 9.4 10.1 1.4 8.5 10.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RBR PF17208.3 EFC39216.1 - 2.3 9.0 11.8 3.1 8.6 10.1 2.1 1 1 0 1 1 1 0 RNA binding Region F-box-like PF12937.7 EFC39217.1 - 0.0053 16.6 0.0 0.0053 16.6 0.0 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC39217.1 - 0.014 15.3 0.4 0.045 13.6 0.4 1.8 1 0 0 1 1 1 0 F-box domain DUF4116 PF13475.6 EFC39218.1 - 2e-12 46.6 1.5 1.9e-06 27.5 1.0 3.3 3 0 0 3 3 3 2 Domain of unknown function (DUF4116) Sel1 PF08238.12 EFC39219.1 - 2.9e-56 186.6 25.4 3.2e-07 30.8 0.1 12.6 13 0 0 13 13 13 11 Sel1 repeat TPR_10 PF13374.6 EFC39219.1 - 0.003 17.4 0.2 35 4.4 0.0 5.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4618 PF15397.6 EFC39219.1 - 0.061 12.7 1.2 0.11 11.9 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) TPR_7 PF13176.6 EFC39219.1 - 0.069 13.2 10.2 6.7 7.0 0.1 7.2 9 1 0 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC39219.1 - 0.074 13.4 15.2 12 6.2 0.4 7.4 7 3 1 8 8 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC39219.1 - 0.076 13.3 8.5 2.3 8.5 0.2 4.5 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFC39219.1 - 0.44 11.2 11.7 4.5 8.0 0.4 4.8 4 2 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC39219.1 - 0.76 9.7 32.7 3.3 7.7 1.6 9.9 11 0 0 11 11 11 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39219.1 - 1.1 9.6 30.6 1.7 9.0 1.6 9.7 12 0 0 12 12 12 0 Tetratricopeptide repeat WD40 PF00400.32 EFC39220.1 - 2.6e-12 47.0 14.5 0.0081 17.0 0.2 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC39220.1 - 0.0024 18.1 1.1 5.9 7.3 0.0 4.2 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EFC39220.1 - 0.014 15.9 5.4 22 5.7 0.1 5.1 4 1 1 5 5 5 0 PQQ-like domain Abhydrolase_3 PF07859.13 EFC39221.1 - 3.8e-21 75.9 0.0 4.7e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC39221.1 - 6e-10 38.5 0.0 1e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EFC39221.1 - 0.006 15.9 0.0 0.0098 15.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC39221.1 - 0.0076 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC39221.1 - 0.087 13.4 0.0 0.12 12.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family SPRY PF00622.28 EFC39223.1 - 0.0037 17.4 1.5 0.013 15.7 0.4 2.0 2 0 0 2 2 2 1 SPRY domain F-box_4 PF15966.5 EFC39223.1 - 0.0074 16.2 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 F-box EF-hand_1 PF00036.32 EFC39224.1 - 2.2e-07 29.9 7.0 2.3e-06 26.7 1.9 3.6 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 EFC39224.1 - 3e-07 30.2 2.6 7.5e-07 28.9 1.6 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC39224.1 - 1.3e-05 24.7 6.6 0.002 17.9 0.4 4.4 4 1 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 EFC39224.1 - 4.4e-05 23.8 5.1 8.9e-05 22.9 1.3 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 EFC39224.1 - 0.0019 17.6 2.6 0.002 17.5 0.5 2.1 2 0 0 2 2 2 1 EF hand PP2C PF00481.21 EFC39225.1 - 3.5e-53 180.9 0.1 6.1e-53 180.1 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 EFC39225.1 - 0.00085 19.0 0.0 0.0019 17.9 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C Ntox50 PF15542.6 EFC39226.1 - 0.13 13.1 3.2 0.23 12.3 2.6 1.8 1 1 0 1 1 1 0 Bacterial toxin 50 DUF1292 PF06949.11 EFC39227.1 - 0.049 14.6 0.4 0.27 12.2 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1292) Pkinase PF00069.25 EFC39228.1 - 1.3e-09 37.8 0.0 2.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SPRY PF00622.28 EFC39228.1 - 8.2e-09 35.6 0.1 7e-08 32.6 0.0 2.6 2 0 0 2 2 2 1 SPRY domain Pkinase_Tyr PF07714.17 EFC39228.1 - 0.0014 18.0 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Peptidase_C26 PF07722.13 EFC39229.1 - 9.6e-17 61.5 0.0 2.6e-16 60.1 0.0 1.7 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 EFC39229.1 - 2.7e-09 37.1 0.0 4.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Synapsin_C PF02750.14 EFC39231.1 - 6.8e-33 113.9 0.0 1.1e-32 113.3 0.0 1.3 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 EFC39231.1 - 4.1e-14 52.7 0.1 3.7e-13 49.6 0.0 2.3 2 0 0 2 2 2 1 Synapsin, N-terminal domain Eapp_C PF10238.9 EFC39231.1 - 0.02 15.0 2.2 0.043 13.9 2.2 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein BILBO1_N PF18281.1 EFC39231.1 - 0.027 14.9 0.5 0.12 12.8 0.5 2.3 1 0 0 1 1 1 0 BILBO1 N-terminal domain PQ-loop PF04193.14 EFC39232.1 - 4.5e-24 84.0 11.6 1.7e-14 53.3 2.9 3.3 4 0 0 4 4 4 2 PQ loop repeat Nucleoside_tran PF01733.18 EFC39232.1 - 0.0016 17.9 3.2 0.0035 16.8 3.2 1.6 1 0 0 1 1 1 1 Nucleoside transporter 7TM_GPCR_Srv PF10323.9 EFC39232.1 - 0.0026 17.1 3.5 0.0026 17.1 3.5 1.7 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF2615 PF11027.8 EFC39232.1 - 0.0054 16.9 5.3 6.5 6.9 0.1 3.9 2 1 2 4 4 4 3 Protein of unknown function (DUF2615) Peptidase_M56 PF05569.11 EFC39232.1 - 0.022 14.0 3.2 0.038 13.2 3.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 Alveol-reg_P311 PF11092.8 EFC39232.1 - 0.11 12.7 0.1 0.35 11.0 0.1 1.8 1 0 0 1 1 1 0 Neuronal protein 3.1 (p311) ER_lumen_recept PF00810.18 EFC39232.1 - 0.2 12.5 13.6 2.7 8.8 0.0 3.9 1 1 2 3 3 3 0 ER lumen protein retaining receptor LRR_6 PF13516.6 EFC39234.1 - 1.1e-29 99.9 30.0 0.00019 21.2 0.1 9.0 9 0 0 9 9 9 7 Leucine Rich repeat LRR_8 PF13855.6 EFC39234.1 - 7.9e-18 64.0 25.0 0.00027 20.6 0.5 5.6 3 2 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC39234.1 - 3.7e-13 49.4 29.7 9.4e-05 22.7 0.3 7.0 2 1 6 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39234.1 - 3.3e-05 23.8 16.5 9 7.3 0.6 7.9 6 2 0 6 6 6 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC39234.1 - 0.001 18.6 10.0 0.51 9.8 0.3 4.1 1 1 3 5 5 5 3 Leucine-rich repeat COesterase PF00135.28 EFC39235.1 - 1.6e-101 340.7 0.2 2e-101 340.4 0.2 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFC39235.1 - 1.1e-08 35.2 0.2 9.5e-08 32.1 0.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC39235.1 - 0.033 13.7 0.0 0.065 12.7 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Myosin_head PF00063.21 EFC39236.1 - 3.8e-262 871.4 8.0 3.8e-262 871.4 8.0 3.3 4 0 0 4 4 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 EFC39236.1 - 9.1e-14 50.3 287.1 6.9e-09 34.1 95.8 5.1 1 1 4 5 5 5 3 Myosin tail EzrA PF06160.12 EFC39236.1 - 6.1e-06 24.7 26.8 6.1e-06 24.7 26.8 8.1 2 2 4 7 7 5 2 Septation ring formation regulator, EzrA Myosin_N PF02736.19 EFC39236.1 - 2.5e-05 24.0 0.4 2.5e-05 24.0 0.4 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain ADIP PF11559.8 EFC39236.1 - 9.6e-05 22.5 21.9 9.6e-05 22.5 21.9 14.7 3 2 11 15 15 14 2 Afadin- and alpha -actinin-Binding Filament PF00038.21 EFC39236.1 - 0.00039 20.1 54.2 0.00039 20.1 54.2 9.9 2 2 4 7 7 7 5 Intermediate filament protein ATG16 PF08614.11 EFC39236.1 - 0.00072 19.8 24.5 0.00072 19.8 24.5 11.3 1 1 10 11 11 9 4 Autophagy protein 16 (ATG16) Fez1 PF06818.15 EFC39236.1 - 0.00099 19.6 59.8 0.0027 18.2 22.7 8.9 2 1 5 9 9 8 4 Fez1 SKA2 PF16740.5 EFC39236.1 - 0.0015 18.3 5.1 0.0015 18.3 5.1 13.5 1 1 10 13 13 9 2 Spindle and kinetochore-associated protein 2 Laminin_II PF06009.12 EFC39236.1 - 0.0042 17.1 9.5 0.0042 17.1 9.5 14.3 3 2 11 15 15 13 5 Laminin Domain II Spc7 PF08317.11 EFC39236.1 - 0.025 13.5 267.7 0.037 12.9 32.3 9.4 1 1 8 9 9 9 0 Spc7 kinetochore protein AAA_19 PF13245.6 EFC39236.1 - 2.1 8.7 6.0 1.4 9.3 0.1 3.3 2 1 0 2 2 2 0 AAA domain BRI3BP PF14965.6 EFC39236.1 - 3.8 7.0 9.1 0.47 10.0 0.1 3.7 3 0 0 3 3 3 0 Negative regulator of p53/TP53 DUF4116 PF13475.6 EFC39237.1 - 2.9e-35 119.7 30.2 2.1e-08 33.7 1.0 10.5 4 4 5 9 9 9 9 Domain of unknown function (DUF4116) Clathrin-link PF09268.10 EFC39237.1 - 0.14 11.6 0.0 0.5 9.8 0.0 2.1 1 0 0 1 1 1 0 Clathrin, heavy-chain linker Sterol_MT_C PF08498.10 EFC39238.1 - 1.1e-24 86.5 0.2 2e-24 85.6 0.2 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal CMAS PF02353.20 EFC39238.1 - 5.7e-12 45.5 0.3 8.1e-12 45.0 0.3 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EFC39238.1 - 1.5e-11 44.8 0.0 2.6e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC39238.1 - 3.9e-09 36.5 0.0 5.6e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC39238.1 - 1.6e-08 35.1 0.0 4e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC39238.1 - 1.9e-07 31.7 0.0 2.9e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC39238.1 - 2.4e-07 30.7 0.0 5.6e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFC39238.1 - 0.07 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) EF-hand_7 PF13499.6 EFC39240.1 - 6.5e-12 45.7 0.2 8.2e-12 45.4 0.2 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC39240.1 - 3.8e-11 42.0 0.1 0.00027 20.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC39240.1 - 9.9e-10 37.3 0.1 0.0017 17.8 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC39240.1 - 1.2e-06 28.3 0.5 3.1e-05 23.7 0.2 1.7 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC39240.1 - 0.00014 22.1 0.1 0.00019 21.7 0.1 1.1 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 EFC39240.1 - 0.026 14.0 0.0 3.9 7.1 0.0 2.3 2 0 0 2 2 2 0 EF hand DUF2813 PF11398.8 EFC39240.1 - 0.094 12.0 0.3 0.12 11.6 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Pro-rich PF15240.6 EFC39240.1 - 2.2 8.6 41.4 3.5 7.9 41.4 1.5 1 1 0 1 1 1 0 Proline-rich TLD PF07534.16 EFC39241.1 - 7.9e-19 68.3 6.1 7.9e-19 68.3 6.1 2.3 2 0 0 2 2 2 1 TLD Pentapeptide_4 PF13599.6 EFC39241.1 - 1.3e-10 41.3 32.3 7.2e-06 26.1 2.9 4.6 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC39241.1 - 2.3e-05 24.4 24.1 7.9e-05 22.7 1.2 5.1 4 2 1 5 5 5 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 EFC39241.1 - 4.1e-05 23.1 14.0 0.1 12.3 0.8 5.7 4 1 1 5 5 5 2 Pentapeptide repeats (8 copies) BTB_2 PF02214.22 EFC39241.1 - 5.3e-05 23.5 0.1 0.00019 21.7 0.1 2.0 1 0 0 1 1 1 1 BTB/POZ domain Pur_ac_phosph_N PF16656.5 EFC39242.1 - 6.5e-06 26.6 0.5 2.4e-05 24.8 0.0 2.2 2 1 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 EFC39242.1 - 0.072 13.5 0.7 0.2 12.0 0.0 2.1 2 0 0 2 2 2 0 Fibronectin type III domain PfkB PF00294.24 EFC39242.1 - 1.1 8.5 4.6 1.8 7.8 4.6 1.3 1 0 0 1 1 1 0 pfkB family carbohydrate kinase HSP33 PF01430.19 EFC39243.1 - 9e-34 117.1 0.0 5.3e-32 111.3 0.0 2.0 1 1 0 1 1 1 1 Hsp33 protein CpXC PF14353.6 EFC39243.1 - 0.042 13.9 0.3 0.11 12.6 0.2 1.7 2 0 0 2 2 2 0 CpXC protein Nop PF01798.18 EFC39244.1 - 1.4e-83 279.9 3.6 2.6e-83 279.0 0.1 2.3 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFC39244.1 - 6.2e-20 71.4 2.8 1.8e-19 69.9 2.8 1.9 1 0 0 1 1 1 1 NOP5NT (NUC127) domain MMR_HSR1_Xtn PF16897.5 EFC39245.1 - 5.3e-41 138.9 0.1 1.2e-40 137.8 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 EFC39245.1 - 4.2e-21 75.1 0.0 9.3e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 EFC39245.1 - 3.6e-20 71.7 0.1 6.2e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 EFC39245.1 - 2.7e-10 40.0 0.1 6.7e-10 38.7 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC39245.1 - 0.00018 21.6 0.1 0.18 11.8 0.0 2.5 1 1 1 2 2 2 2 Dynamin family MeaB PF03308.16 EFC39245.1 - 0.0016 17.4 0.0 0.0035 16.4 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EFC39245.1 - 0.021 14.4 0.2 13 5.3 0.0 3.8 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain KTI12 PF08433.10 EFC39245.1 - 0.049 13.1 0.2 1.4 8.3 0.0 2.6 3 0 0 3 3 3 0 Chromatin associated protein KTI12 NB-ARC PF00931.22 EFC39245.1 - 0.052 12.7 0.0 0.088 12.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AIG1 PF04548.16 EFC39245.1 - 0.06 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 AIG1 family BRCT_2 PF16589.5 EFC39246.1 - 0.12 12.8 4.9 0.15 12.5 3.5 1.8 1 1 1 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain PX PF00787.24 EFC39247.1 - 6.3e-14 51.9 2.4 6.3e-14 51.9 2.4 1.5 2 0 0 2 2 2 1 PX domain Plant_NMP1 PF06694.11 EFC39247.1 - 0.015 14.4 1.2 0.035 13.2 0.5 1.7 1 1 1 2 2 2 0 Plant nuclear matrix protein 1 (NMP1) WD40 PF00400.32 EFC39248.1 - 6.5e-38 128.1 12.4 5e-07 30.3 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat adh_short PF00106.25 EFC39248.1 - 1.1e-26 93.5 0.0 2.1e-26 92.6 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase ANAPC4_WD40 PF12894.7 EFC39248.1 - 1.8e-18 66.6 3.1 0.0016 18.7 0.0 6.0 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain adh_short_C2 PF13561.6 EFC39248.1 - 5e-18 65.5 0.1 1.4e-17 64.1 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39248.1 - 1.3e-06 28.5 0.0 2.5e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 KR domain Nucleoporin_N PF08801.11 EFC39248.1 - 4.1e-05 22.5 6.2 0.024 13.4 0.4 3.5 2 1 0 3 3 3 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 EFC39248.1 - 0.0001 21.0 0.1 0.32 9.5 0.0 3.1 1 1 2 3 3 3 2 Cytochrome D1 heme domain HPS3_N PF14761.6 EFC39248.1 - 0.0009 18.8 0.1 2.9 7.4 0.0 3.5 3 1 0 3 3 3 1 Hermansky-Pudlak syndrome 3 Polysacc_synt_2 PF02719.15 EFC39248.1 - 0.0013 18.0 0.0 0.0028 16.8 0.0 1.7 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Ge1_WD40 PF16529.5 EFC39248.1 - 0.0048 15.9 4.2 3 6.7 0.2 4.0 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC39248.1 - 0.0098 15.2 13.2 0.071 12.4 0.6 4.0 4 1 0 4 4 4 2 WD40-like domain Frtz PF11768.8 EFC39248.1 - 0.055 11.8 3.0 0.67 8.2 0.1 3.0 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 EFC39248.1 - 0.096 12.4 0.2 3.2 7.4 0.1 2.8 1 1 2 3 3 3 0 TUP1-like enhancer of split DUF1829 PF08862.10 EFC39248.1 - 0.13 12.7 1.3 18 5.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF1829 Clathrin-link PF09268.10 EFC39248.1 - 5 6.6 8.1 0.99 8.8 1.0 2.8 3 0 0 3 3 3 0 Clathrin, heavy-chain linker Ras PF00071.22 EFC39250.1 - 2.9e-21 75.7 0.1 1.2e-17 64.0 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC39250.1 - 6.7e-07 29.6 0.0 0.013 15.7 0.1 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC39250.1 - 6.6e-05 22.9 0.0 0.36 10.7 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC39250.1 - 0.0023 17.5 0.0 0.17 11.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFC39250.1 - 0.02 14.4 0.0 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFC39250.1 - 0.022 14.8 0.0 0.035 14.2 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC39250.1 - 0.053 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC39250.1 - 0.075 13.4 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFC39250.1 - 0.084 12.6 0.0 3.9 7.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain Guanylate_cyc PF00211.20 EFC39251.1 - 1.5e-15 57.3 0.1 4.4e-10 39.5 0.0 2.6 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain Bac_DnaA PF00308.18 EFC39251.1 - 0.011 15.6 0.4 1.7 8.5 0.3 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_16 PF13191.6 EFC39251.1 - 0.05 14.0 0.0 0.17 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain TPR_2 PF07719.17 EFC39251.1 - 0.081 13.1 0.3 0.41 10.9 0.3 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF1363 PF07101.11 EFC39251.1 - 0.095 13.0 0.2 1.5 9.1 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1363) DUF4639 PF15479.6 EFC39251.1 - 5.9 5.7 8.9 9.4 5.1 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) DUF4209 PF13910.6 EFC39252.1 - 1.5e-25 89.3 2.4 1.1e-23 83.2 0.2 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF4209) HSL_N PF06350.12 EFC39252.1 - 0.045 12.7 0.1 0.09 11.7 0.1 1.4 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus NmrA PF05368.13 EFC39253.1 - 9.2e-42 143.2 1.2 1.1e-41 142.9 1.2 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC39253.1 - 6.4e-20 71.8 0.4 1.8e-19 70.4 0.2 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC39253.1 - 2e-08 34.0 0.1 2e-07 30.7 0.1 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 EFC39253.1 - 1.8e-06 28.1 0.4 1.8e-06 28.1 0.4 2.0 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.20 EFC39253.1 - 7.6e-06 26.0 1.3 9.8e-06 25.7 0.4 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 EFC39253.1 - 0.00031 20.3 1.2 0.16 11.4 0.1 3.0 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 EFC39253.1 - 0.00052 20.4 0.1 0.0012 19.3 0.1 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFC39253.1 - 0.00097 19.4 1.3 0.0017 18.6 0.3 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 EFC39253.1 - 0.0013 17.9 0.9 0.0032 16.7 0.2 2.0 2 1 0 2 2 2 1 Male sterility protein GARS_N PF02844.15 EFC39253.1 - 0.003 18.3 0.9 0.01 16.6 0.1 2.2 2 1 0 3 3 2 1 Phosphoribosylglycinamide synthetase, N domain DXP_reductoisom PF02670.16 EFC39253.1 - 0.0045 17.7 3.4 0.23 12.2 0.7 2.3 2 0 0 2 2 2 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Ldh_1_N PF00056.23 EFC39253.1 - 0.013 15.6 0.4 0.034 14.2 0.4 1.7 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFC39253.1 - 0.021 14.0 0.9 1.5 7.9 0.2 2.7 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein DUF211 PF02680.14 EFC39253.1 - 0.023 14.8 2.7 0.15 12.2 0.3 2.6 2 1 0 2 2 2 0 Uncharacterized ArCR, COG1888 KR PF08659.10 EFC39253.1 - 0.046 13.6 1.5 0.052 13.5 0.4 1.7 2 0 0 2 2 2 0 KR domain Pet191_N PF10203.9 EFC39254.1 - 0.016 15.5 6.2 0.016 15.5 6.2 3.5 4 1 0 4 4 4 0 Cytochrome c oxidase assembly protein PET191 Rhomboid PF01694.22 EFC39255.1 - 6.5e-10 39.2 10.3 2.8e-09 37.1 10.3 1.9 1 1 0 1 1 1 1 Rhomboid family DER1 PF04511.15 EFC39255.1 - 2.5e-06 27.6 2.6 2.5e-06 27.6 2.6 2.0 2 0 0 2 2 2 1 Der1-like family DEAD PF00270.29 EFC39256.1 - 1e-14 54.7 0.0 1.5e-14 54.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase LRR_8 PF13855.6 EFC39257.1 - 9.3e-16 57.3 43.5 7.7e-06 25.6 6.9 6.9 3 2 5 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 EFC39257.1 - 1.1e-14 54.3 37.3 6.6e-05 23.2 0.4 9.2 3 2 9 12 12 12 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC39257.1 - 2.2e-10 39.8 25.7 0.096 12.8 0.2 9.4 8 0 0 8 8 8 5 Leucine Rich repeat LRR_9 PF14580.6 EFC39257.1 - 3.6e-06 26.6 8.0 0.00052 19.6 1.5 3.8 1 1 2 4 4 4 3 Leucine-rich repeat FA_desaturase PF00487.24 EFC39258.1 - 6.4 6.5 6.1 8.6 6.1 5.5 1.5 1 1 0 1 1 1 0 Fatty acid desaturase FH2 PF02181.23 EFC39259.1 - 1.4e-50 172.5 24.5 4.6e-50 170.8 24.5 2.0 1 0 0 1 1 1 1 Formin Homology 2 Domain LRR_4 PF12799.7 EFC39259.1 - 0.00022 21.6 21.0 0.002 18.5 3.9 4.9 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC39259.1 - 0.00059 19.4 2.6 0.00059 19.4 2.6 4.7 3 2 2 5 5 5 2 Leucine-rich repeat LRR_8 PF13855.6 EFC39259.1 - 0.0042 16.8 3.6 0.0042 16.8 3.6 4.0 2 2 2 4 4 4 1 Leucine rich repeat Ago_N_1 PF18351.1 EFC39259.1 - 0.88 10.0 4.4 2.8 8.4 0.2 3.0 2 0 0 2 2 2 0 Fungal Argonaute N-terminal domain Tma16 PF11176.8 EFC39259.1 - 2.2 8.1 7.4 0.66 9.8 1.0 3.3 3 0 0 3 3 3 0 Translation machinery-associated protein 16 ECH_1 PF00378.20 EFC39260.1 - 2e-44 151.8 0.0 3e-44 151.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC39260.1 - 5.9e-14 52.3 0.0 3.5e-13 49.7 0.0 2.0 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Toxin_3 PF00537.18 EFC39260.1 - 8.1 6.7 9.0 1.1 9.5 2.1 2.7 3 0 0 3 3 3 0 Scorpion toxin-like domain Pkinase PF00069.25 EFC39261.1 - 9e-50 169.5 0.0 1.4e-49 168.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39261.1 - 2.8e-34 118.6 0.0 4.2e-34 118.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 EFC39261.1 - 0.071 12.2 0.1 0.13 11.3 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 PBP1_TM PF14812.6 EFC39261.1 - 0.47 10.9 6.7 0.2 12.1 2.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aldo_ket_red PF00248.21 EFC39262.1 - 9.7e-78 261.3 0.0 1.1e-77 261.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HpuA PF16960.5 EFC39262.1 - 0.06 12.5 0.0 0.087 12.0 0.0 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter 2OG-FeII_Oxy_3 PF13640.6 EFC39264.1 - 4e-14 53.3 0.1 1e-13 52.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFC39264.1 - 2e-06 27.2 0.7 5e-05 22.6 0.0 2.8 3 0 0 3 3 3 1 Poxvirus C4/C10 protein F-box-like PF12937.7 EFC39264.1 - 9.6e-05 22.2 0.3 0.00022 21.1 0.3 1.7 1 0 0 1 1 1 1 F-box-like 2OG-FeII_Oxy PF03171.20 EFC39264.1 - 0.00014 22.3 0.0 0.00051 20.5 0.0 2.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EFC39264.1 - 0.0013 19.3 0.0 0.0031 18.1 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 EFC39266.1 - 8.3e-17 62.0 0.0 1.4e-15 58.0 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC39266.1 - 0.0045 17.4 0.1 0.013 15.9 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily TetR_C_27 PF17935.1 EFC39266.1 - 0.12 12.4 0.0 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4834 PF16118.5 EFC39267.1 - 0.067 14.2 1.5 0.067 14.2 1.5 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) UBA_2 PF08587.11 EFC39268.1 - 0.047 13.8 0.1 0.58 10.3 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) IL4_i_Ig PF18258.1 EFC39269.1 - 0.15 12.3 0.3 0.51 10.6 0.3 2.0 1 0 0 1 1 1 0 Interleukin-4 inducing immunoglobulin-binding domain KOG2701 PF09762.9 EFC39269.1 - 5.1 7.3 9.2 0.28 11.4 2.2 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein (DUF2037) SAM_1 PF00536.30 EFC39271.1 - 3.2e-08 33.9 0.9 1.1e-07 32.2 0.9 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RGS PF00615.19 EFC39271.1 - 7.2e-05 23.0 13.7 0.0047 17.2 8.6 3.1 2 1 0 2 2 2 1 Regulator of G protein signaling domain SAM_2 PF07647.17 EFC39271.1 - 0.0017 18.4 0.3 0.0041 17.2 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LacI PF00356.21 EFC39271.1 - 0.064 13.1 0.2 0.28 11.0 0.1 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Tctex-1 PF03645.13 EFC39271.1 - 0.31 11.3 5.0 1.5 9.1 2.4 2.4 2 0 0 2 2 2 0 Tctex-1 family VSG_B PF13206.6 EFC39271.1 - 0.46 9.7 6.1 0.82 8.9 6.1 1.4 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF87 PF01935.17 EFC39271.1 - 3.1 7.8 8.9 5.6 7.0 4.6 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain TPR_12 PF13424.6 EFC39272.1 - 6.2e-09 36.0 5.0 0.02 15.2 0.1 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC39272.1 - 0.00095 19.0 0.1 0.0077 16.1 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat OmpH PF03938.14 EFC39272.1 - 0.0016 18.8 3.1 0.0016 18.8 3.1 3.5 3 0 0 3 3 3 1 Outer membrane protein (OmpH-like) TPR_19 PF14559.6 EFC39272.1 - 0.036 14.6 3.8 12 6.5 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF883 PF05957.13 EFC39272.1 - 0.038 14.6 7.6 0.065 13.8 0.4 3.6 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF883) TrmO_C PF18389.1 EFC39272.1 - 0.07 13.3 0.1 0.26 11.4 0.1 2.0 1 0 0 1 1 1 0 TrmO C-terminal domain TPR_14 PF13428.6 EFC39272.1 - 0.091 13.6 1.6 0.97 10.4 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Peripla_BP_2 PF01497.18 EFC39272.1 - 0.24 10.9 3.3 13 5.3 0.0 2.9 3 0 0 3 3 3 0 Periplasmic binding protein PMC2NT PF08066.12 EFC39272.1 - 0.33 11.7 2.7 8.2 7.2 0.0 3.3 3 0 0 3 3 3 0 PMC2NT (NUC016) domain TipAS PF07739.13 EFC39272.1 - 0.35 11.4 0.1 0.35 11.4 0.1 3.3 3 0 0 3 3 3 0 TipAS antibiotic-recognition domain TPR_7 PF13176.6 EFC39272.1 - 2.9 8.1 12.1 1.5 9.0 0.0 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC39272.1 - 5 7.1 10.7 53 3.9 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat Abhydrolase_1 PF00561.20 EFC39273.1 - 1.8e-06 27.8 0.0 0.032 13.9 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC39273.1 - 0.062 12.6 0.0 6.2 6.0 0.0 2.3 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Esterase PF00756.20 EFC39273.1 - 0.069 12.8 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 EFC39274.1 - 2.3e-10 40.2 0.4 1.2e-08 34.5 0.4 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC39274.1 - 5e-07 30.6 0.1 8.9e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 EFC39274.1 - 1.1e-05 25.0 0.1 0.008 15.7 0.1 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC39274.1 - 0.00032 20.4 0.1 0.38 10.3 0.2 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 EFC39274.1 - 0.005 15.6 0.4 0.065 11.9 0.1 2.1 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) PAP2_3 PF14378.6 EFC39274.1 - 0.053 13.2 0.3 0.094 12.4 0.3 1.3 1 0 0 1 1 1 0 PAP2 superfamily Acyl_transf_2 PF02273.15 EFC39274.1 - 0.054 12.7 0.0 0.084 12.1 0.0 1.3 1 0 0 1 1 1 0 Acyl transferase NAAA-beta PF15508.6 EFC39275.1 - 2.1e-09 37.6 0.4 4.1e-09 36.6 0.4 1.5 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase HECT PF00632.25 EFC39276.1 - 3.9e-85 286.0 2.6 6e-85 285.4 0.1 2.3 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) WD40 PF00400.32 EFC39276.1 - 2.8e-20 72.3 6.5 2.6e-08 34.4 0.0 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat Nucleoporin_N PF08801.11 EFC39276.1 - 1.6e-05 23.8 0.8 0.0077 15.0 0.2 2.4 1 1 0 2 2 2 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 EFC39276.1 - 5.7e-05 23.3 0.6 0.15 12.4 0.2 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC39276.1 - 0.021 13.5 7.6 0.042 12.5 0.3 3.2 3 1 1 4 4 4 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EFC39276.1 - 0.022 15.3 0.0 25 5.5 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain PTR2 PF00854.21 EFC39277.1 - 0.021 13.7 0.5 0.093 11.5 0.1 1.9 2 0 0 2 2 2 0 POT family PTR2 PF00854.21 EFC39278.1 - 0.037 12.9 0.1 0.053 12.4 0.1 1.2 1 0 0 1 1 1 0 POT family SKI PF01202.22 EFC39279.1 - 7.3e-07 29.4 0.2 6.1e-06 26.4 0.2 2.1 1 1 0 1 1 1 1 Shikimate kinase AAA_18 PF13238.6 EFC39279.1 - 1.6e-05 25.5 0.9 3.3e-05 24.4 0.9 1.5 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.20 EFC39279.1 - 4e-05 23.6 0.0 6.3e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 EFC39279.1 - 0.00052 20.2 0.0 0.0011 19.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain 6PF2K PF01591.18 EFC39279.1 - 0.00056 19.3 0.0 0.00095 18.5 0.0 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase ABC_tran PF00005.27 EFC39279.1 - 0.0047 17.4 0.1 0.0081 16.7 0.1 1.7 1 1 0 1 1 1 1 ABC transporter KTI12 PF08433.10 EFC39279.1 - 0.0077 15.7 0.1 0.047 13.1 0.0 2.1 2 1 0 2 2 2 1 Chromatin associated protein KTI12 PRK PF00485.18 EFC39279.1 - 0.012 15.4 0.0 0.028 14.2 0.0 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 EFC39279.1 - 0.023 14.0 0.0 0.18 11.1 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 EFC39279.1 - 0.026 14.9 0.0 0.06 13.7 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EFC39279.1 - 0.029 14.8 0.4 0.12 12.8 0.1 2.2 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) CPT PF07931.12 EFC39279.1 - 0.048 13.5 0.0 0.2 11.4 0.0 1.9 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein dNK PF01712.19 EFC39279.1 - 0.059 13.2 0.2 0.2 11.5 0.2 1.9 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_23 PF13476.6 EFC39279.1 - 0.47 10.9 3.0 0.93 10.0 3.0 1.7 1 1 0 1 1 1 0 AAA domain YdjM PF04307.14 EFC39280.1 - 9.7e-16 57.5 1.4 2e-15 56.5 1.4 1.4 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase PAT1 PF09770.9 EFC39280.1 - 0.051 11.9 0.2 0.089 11.1 0.2 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 La PF05383.17 EFC39281.1 - 4.9e-27 93.8 0.2 9.1e-27 92.9 0.2 1.5 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFC39281.1 - 6.5e-08 32.3 1.1 1e-06 28.4 0.2 2.9 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3993 PF13158.6 EFC39281.1 - 0.12 12.6 0.1 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) G-alpha PF00503.20 EFC39283.1 - 3.9e-36 124.9 14.2 1.9e-35 122.7 14.2 1.8 1 1 0 1 1 1 1 G-protein alpha subunit T2SSE PF00437.20 EFC39283.1 - 0.045 12.8 0.0 0.065 12.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3450 PF11932.8 EFC39284.1 - 0.024 13.9 0.2 0.041 13.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) UvrD-helicase PF00580.21 EFC39285.1 - 8.2e-36 124.1 1.8 8.8e-17 61.6 0.2 2.8 1 1 1 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 EFC39285.1 - 1.8e-26 93.4 0.5 3.9e-15 56.1 0.0 3.2 2 1 1 3 3 3 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 EFC39285.1 - 1.8e-26 93.2 0.0 3e-24 86.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EFC39285.1 - 3e-15 55.8 0.0 6.4e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 EFC39285.1 - 1.7e-10 40.9 0.0 3.6e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFC39285.1 - 3.8e-10 39.9 1.0 3e-05 23.9 0.1 3.8 3 1 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 EFC39285.1 - 3.2e-07 30.2 3.7 1.1e-05 25.2 0.0 3.8 3 1 1 4 4 4 1 AAA domain DEAD PF00270.29 EFC39285.1 - 0.0025 17.6 0.2 0.011 15.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_14 PF13173.6 EFC39285.1 - 0.0038 17.3 1.0 0.019 15.0 1.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC39285.1 - 0.19 12.0 1.7 2.7 8.3 1.0 2.8 2 1 0 2 2 2 0 AAA domain ResIII PF04851.15 EFC39285.1 - 2.9 7.9 7.3 7.6 6.5 0.0 3.3 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 EFC39286.1 - 3.1e-07 30.3 2.8 3.1e-07 30.3 2.8 3.7 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFC39286.1 - 1.9e-06 27.9 3.2 1.9e-06 27.9 3.2 4.6 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFC39286.1 - 5e-06 26.3 3.5 5e-06 26.3 3.5 3.6 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC39286.1 - 5.2e-06 26.2 3.2 5.2e-06 26.2 3.2 4.0 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 EFC39286.1 - 0.00015 21.8 6.3 0.00015 21.8 6.3 5.1 6 0 0 6 6 6 1 B-box zinc finger zf-C3HC4_3 PF13920.6 EFC39286.1 - 0.00062 19.6 2.5 0.00062 19.6 2.5 3.9 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC39286.1 - 0.0045 17.3 3.0 0.0045 17.3 3.0 4.2 5 0 0 5 5 5 2 Ring finger domain Prok-RING_4 PF14447.6 EFC39286.1 - 0.0097 15.7 2.8 0.0097 15.7 2.8 4.1 4 0 0 4 4 4 1 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EFC39286.1 - 0.028 14.6 2.4 0.028 14.6 2.4 3.5 4 0 0 4 4 4 0 zinc RING finger of MSL2 U-box PF04564.15 EFC39286.1 - 0.056 13.6 0.1 1.2 9.4 0.0 2.7 3 0 0 3 3 3 0 U-box domain Serpin PF00079.20 EFC39288.1 - 4.7e-82 276.2 9.0 5.5e-82 276.0 9.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_C3 PF00548.20 EFC39288.1 - 0.063 13.2 1.2 0.12 12.3 0.5 1.8 2 0 0 2 2 2 0 3C cysteine protease (picornain 3C) T3RM_EcoP15I_C PF18273.1 EFC39288.1 - 0.26 11.6 4.1 1 9.7 0.8 2.8 1 1 0 2 2 2 0 Type III R-M EcoP15I C-terminal domain AT_hook PF02178.19 EFC39289.1 - 0.0016 18.1 2.7 0.0035 17.1 2.7 1.6 1 0 0 1 1 1 1 AT hook motif RFX5_DNA_bdg PF14621.6 EFC39289.1 - 0.045 13.5 2.3 0.065 13.0 2.3 1.2 1 0 0 1 1 1 0 RFX5 DNA-binding domain Hydrolase_3 PF08282.12 EFC39289.1 - 0.07 12.9 4.1 0.088 12.5 4.1 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4116 PF13475.6 EFC39290.1 - 2.2e-35 120.1 2.3 1.9e-15 56.3 0.0 3.7 2 1 2 4 4 4 4 Domain of unknown function (DUF4116) ubiquitin PF00240.23 EFC39290.1 - 0.0047 16.6 0.1 0.021 14.6 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin family LRR_6 PF13516.6 EFC39291.1 - 8.1e-22 75.4 9.6 0.0023 17.8 0.0 7.1 7 0 0 7 7 7 6 Leucine Rich repeat LRR_8 PF13855.6 EFC39291.1 - 2.4e-17 62.5 4.5 6.9e-06 25.7 0.3 3.6 1 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC39291.1 - 7.3e-11 42.1 20.3 0.0017 18.7 0.6 5.6 4 1 3 7 7 7 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39291.1 - 1.4e-06 28.1 0.6 55 4.9 0.0 7.2 7 0 0 7 7 7 0 Leucine Rich Repeat F-box-like PF12937.7 EFC39291.1 - 0.012 15.5 0.1 0.025 14.5 0.1 1.4 1 0 0 1 1 1 0 F-box-like PI-TkoII_IV PF18714.1 EFC39291.1 - 0.044 13.3 0.1 0.095 12.2 0.1 1.6 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV DUF4347 PF14252.6 EFC39291.1 - 0.048 13.5 0.0 5.6 6.8 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4347) FAD_binding_3 PF01494.19 EFC39294.1 - 5.7e-24 85.0 0.2 7.3e-23 81.4 0.2 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFC39294.1 - 1.9e-06 28.0 0.1 3.8e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFC39294.1 - 0.00012 21.4 0.0 0.0033 16.7 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFC39294.1 - 0.001 18.4 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EFC39294.1 - 0.001 17.8 0.0 0.003 16.3 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFC39294.1 - 0.0015 18.2 0.0 0.0072 15.9 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC39294.1 - 0.0046 16.2 0.0 0.011 15.0 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC39294.1 - 0.0058 17.2 0.0 0.015 15.8 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 EFC39294.1 - 0.007 15.4 0.0 1.4 7.9 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase Amino_oxidase PF01593.24 EFC39294.1 - 0.023 14.0 0.0 0.77 9.0 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 EFC39294.1 - 0.025 14.6 0.0 0.076 13.0 0.0 1.8 2 0 0 2 2 2 0 FAD-NAD(P)-binding Filo_VP35 PF02097.15 EFC39294.1 - 0.034 13.2 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 Filoviridae VP35 NAD_Gly3P_dh_N PF01210.23 EFC39294.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.12 EFC39294.1 - 0.13 11.3 0.0 0.53 9.3 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 EFC39294.1 - 0.2 11.5 0.1 0.35 10.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF4116 PF13475.6 EFC39295.1 - 1.3e-163 530.7 60.9 1.2e-15 56.9 0.0 21.5 8 4 10 22 22 22 22 Domain of unknown function (DUF4116) DUF2229 PF09989.9 EFC39295.1 - 0.026 14.2 1.4 0.63 9.7 0.1 2.7 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) UPF0181 PF03701.14 EFC39295.1 - 0.085 12.5 0.3 9.3 6.0 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) ESP PF16590.5 EFC39295.1 - 0.37 11.1 7.3 5.3 7.4 0.0 4.7 4 1 1 5 5 5 0 Exocrine gland-secreting peptide OTU PF02338.19 EFC39296.1 - 1e-14 55.1 0.0 2.5e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease EGF_2 PF07974.13 EFC39296.1 - 5.5e-07 29.9 40.9 0.00051 20.3 9.3 3.6 3 0 0 3 3 3 3 EGF-like domain NHL PF01436.21 EFC39296.1 - 0.0028 17.6 0.0 0.67 10.1 0.0 3.8 3 0 0 3 3 3 1 NHL repeat Peptidase_C65 PF10275.9 EFC39296.1 - 0.0031 17.0 7.8 0.066 12.7 0.1 3.4 3 0 0 3 3 3 2 Peptidase C65 Otubain LMBR1 PF04791.16 EFC39296.1 - 0.014 14.3 2.7 0.024 13.5 2.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ASC PF00858.24 EFC39296.1 - 0.027 13.5 0.2 0.027 13.5 0.2 4.2 3 1 1 4 4 3 0 Amiloride-sensitive sodium channel SGL PF08450.12 EFC39296.1 - 0.041 13.5 0.1 13 5.3 0.0 3.3 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region TrkH PF02386.16 EFC39296.1 - 0.043 12.3 0.0 0.068 11.6 0.0 1.2 1 0 0 1 1 1 0 Cation transport protein EGF PF00008.27 EFC39296.1 - 0.099 13.0 31.1 0.095 13.0 8.5 3.6 3 0 0 3 3 3 0 EGF-like domain MSL1_dimer PF16801.5 EFC39296.1 - 1.1 9.0 4.3 2.7 7.8 4.3 1.6 1 0 0 1 1 1 0 Dimerisation domain of Male-specific-Lethal 1 DUF3446 PF11928.8 EFC39296.1 - 1.4 9.3 20.9 0.11 12.8 2.3 3.0 2 0 0 2 2 2 0 Early growth response N-terminal domain NHL PF01436.21 EFC39297.1 - 9.3e-28 94.8 12.4 3e-07 30.1 0.1 6.7 7 0 0 7 7 7 5 NHL repeat BTB PF00651.31 EFC39297.1 - 8.1e-14 51.8 0.5 1.6e-13 50.8 0.5 1.5 1 0 0 1 1 1 1 BTB/POZ domain SGL PF08450.12 EFC39297.1 - 0.0028 17.3 0.1 2.2 7.8 0.1 3.9 2 2 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC39297.1 - 0.021 15.0 2.5 22 5.4 0.1 5.0 5 1 1 6 6 6 0 Arylesterase YqzH PF14164.6 EFC39297.1 - 0.034 14.2 0.6 0.034 14.2 0.6 1.9 2 0 0 2 2 2 0 YqzH-like protein MACPF PF01823.19 EFC39298.1 - 8e-08 32.6 0.3 2.4e-07 31.0 0.3 1.8 1 1 0 1 1 1 1 MAC/Perforin domain WD40 PF00400.32 EFC39299.1 - 2.8e-07 31.1 3.4 0.0059 17.4 0.2 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC39299.1 - 3.2e-07 30.5 0.0 0.018 15.3 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC39299.1 - 0.0024 16.9 2.8 0.97 8.3 0.1 2.8 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CNH PF00780.22 EFC39299.1 - 0.019 14.6 0.1 0.68 9.5 0.0 2.1 2 0 0 2 2 2 0 CNH domain BBS2_N PF14781.6 EFC39299.1 - 0.071 13.0 0.3 2 8.4 0.0 3.0 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal WD40_like PF17005.5 EFC39299.1 - 0.11 11.8 3.9 2.2 7.6 0.1 2.9 3 0 0 3 3 3 0 WD40-like domain Pinin_SDK_memA PF04696.13 EFC39301.1 - 0.0076 16.3 5.8 0.019 15.0 5.8 1.6 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region Gp-FAR-1 PF05823.12 EFC39301.1 - 0.016 15.6 0.3 0.29 11.5 0.3 2.5 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) DUF4870 PF09685.10 EFC39302.1 - 0.024 14.8 3.1 0.036 14.2 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) SUR7 PF06687.12 EFC39302.1 - 0.5 10.0 5.4 0.63 9.6 5.4 1.1 1 0 0 1 1 1 0 SUR7/PalI family DUF2207 PF09972.9 EFC39302.1 - 0.72 8.6 4.4 1.1 7.9 4.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2367 PF10164.9 EFC39302.1 - 2.5 8.6 6.9 6.4 7.3 6.9 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) DUF4013 PF13197.6 EFC39302.1 - 4.9 7.0 16.2 1.7 8.5 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4013) TetR_C_22 PF17928.1 EFC39303.1 - 0.024 15.0 0.1 0.9 9.9 0.0 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF3452 PF11934.8 EFC39303.1 - 0.049 13.2 0.5 0.049 13.2 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) Phg_2220_C PF09524.10 EFC39303.1 - 0.56 10.3 7.6 25 5.0 0.7 4.4 4 0 0 4 4 4 0 Conserved phage C-terminus (Phg_2220_C) EF-hand_2 PF09068.11 EFC39303.1 - 3.5 7.8 5.6 8.4 6.6 5.6 1.8 1 1 0 1 1 1 0 EF hand SPRY PF00622.28 EFC39304.1 - 0.00049 20.2 0.1 0.12 12.5 0.0 2.3 2 0 0 2 2 2 2 SPRY domain Big_9 PF17963.1 EFC39305.1 - 1.6e-91 301.2 190.7 1.1e-18 67.8 10.9 15.2 13 3 2 15 15 15 14 Bacterial Ig domain Cadherin_4 PF17803.1 EFC39305.1 - 3.8e-55 184.4 140.5 6.3e-10 39.5 2.5 14.6 13 1 0 13 13 13 12 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFC39305.1 - 3.5e-17 62.2 108.0 3.6e-07 30.1 0.5 14.6 12 3 4 16 16 16 8 Cadherin-like domain VWA PF00092.28 EFC39305.1 - 8.8e-16 58.6 0.2 5.2e-15 56.1 0.1 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC39305.1 - 1.7e-09 38.3 0.4 1.1e-08 35.7 0.2 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain RNase_H PF00075.24 EFC39306.1 - 1.4e-06 28.6 2.1 1.8e-06 28.2 0.6 1.9 2 0 0 2 2 2 1 RNase H zf-RVT PF13966.6 EFC39306.1 - 0.017 15.8 0.5 0.064 14.0 0.1 2.2 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase Trypan_PARP PF05887.11 EFC39307.1 - 1.6e-06 28.1 115.1 0.0069 16.4 35.3 3.8 1 1 3 4 4 4 3 Procyclic acidic repetitive protein (PARP) Presenilin PF01080.17 EFC39307.1 - 1.7 7.3 10.9 1.7 7.3 10.9 1.2 1 0 0 1 1 1 0 Presenilin NopRA1 PF16201.5 EFC39308.1 - 0.00041 20.0 1.6 0.86 9.1 0.0 3.0 3 0 0 3 3 3 2 Nucleolar pre-ribosomal-associated protein 1 CSN7a_helixI PF18392.1 EFC39308.1 - 0.034 14.1 0.3 0.073 13.0 0.3 1.5 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain Copine PF07002.16 EFC39309.1 - 7.6e-17 61.5 0.0 1.9e-16 60.2 0.0 1.7 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFC39309.1 - 0.00093 19.4 0.7 0.0064 16.6 0.2 2.4 2 0 0 2 2 2 1 vWA found in TerF C terminus C2 PF00168.30 EFC39309.1 - 0.047 14.0 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 C2 domain DUF5127 PF17168.4 EFC39309.1 - 0.085 12.6 0.3 0.19 11.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5127) DUF3007 PF11460.8 EFC39310.1 - 0.72 10.1 3.2 0.43 10.9 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3007) DUF433 PF04255.14 EFC39311.1 - 0.085 12.7 0.0 0.33 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF433) Ribosomal_S10 PF00338.22 EFC39312.1 - 6.8e-27 93.6 0.7 8.3e-27 93.3 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e CinA_KH PF18146.1 EFC39312.1 - 0.12 12.6 0.4 0.33 11.1 0.3 1.8 2 0 0 2 2 2 0 Damage-inducible protein CinA KH domain SMK-1 PF04802.15 EFC39313.1 - 7.2e-60 202.1 12.9 7.2e-60 202.1 12.9 2.6 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 DUF4116 PF13475.6 EFC39314.1 - 1.3e-46 156.1 28.2 7.3e-12 44.8 0.2 10.3 5 1 7 12 12 12 11 Domain of unknown function (DUF4116) DUF4296 PF14129.6 EFC39314.1 - 0.083 13.5 0.1 0.2 12.3 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) ACP_PD PF04336.12 EFC39314.1 - 0.083 13.3 0.1 0.98 9.9 0.0 2.5 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase Fe-S_biosyn PF01521.20 EFC39314.1 - 0.1 12.8 0.1 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Iron-sulphur cluster biosynthesis KIP1 PF07765.12 EFC39314.1 - 0.36 11.0 2.3 1.4 9.1 0.2 2.9 2 1 1 3 3 3 0 KIP1-like protein Collagen PF01391.18 EFC39315.1 - 0.00016 21.3 16.3 0.00016 21.3 16.3 4.7 2 2 0 3 3 3 1 Collagen triple helix repeat (20 copies) NHL PF01436.21 EFC39316.1 - 2.3e-60 197.7 9.4 5.2e-07 29.4 0.1 13.2 14 0 0 14 14 14 10 NHL repeat Arylesterase PF01731.20 EFC39316.1 - 9.3e-17 61.0 4.2 0.047 13.9 0.0 7.9 8 2 2 10 10 10 4 Arylesterase EGF_2 PF07974.13 EFC39316.1 - 1.2e-09 38.3 102.4 0.00065 20.0 9.1 6.1 6 0 0 6 6 6 5 EGF-like domain Linker_histone PF00538.19 EFC39316.1 - 0.0001 22.6 0.3 1.8e+02 2.6 0.0 7.0 7 0 0 7 7 7 0 linker histone H1 and H5 family EGF PF00008.27 EFC39316.1 - 0.0019 18.5 72.4 0.11 12.8 7.1 5.9 5 0 0 5 5 5 3 EGF-like domain GTP1_OBG PF01018.22 EFC39316.1 - 0.39 10.3 11.4 6 6.4 0.1 5.0 3 1 3 6 6 6 0 GTP1/OBG hEGF PF12661.7 EFC39316.1 - 2 9.2 80.7 0.05 14.3 6.4 6.6 7 0 0 7 7 7 0 Human growth factor-like EGF PPC PF04151.15 EFC39316.1 - 3.5 8.8 5.3 44 5.3 0.6 4.3 3 0 0 3 3 3 0 Bacterial pre-peptidase C-terminal domain SBDS PF01172.18 EFC39316.1 - 5.9 7.0 7.9 1.3e+02 2.7 0.0 5.1 7 0 0 7 7 7 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein UQ_con PF00179.26 EFC39319.1 - 5.8e-40 136.2 0.0 8.7e-40 135.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF4171 PF13775.6 EFC39319.1 - 0.00081 19.8 11.6 0.0012 19.3 11.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4171) RWD PF05773.22 EFC39319.1 - 0.0055 17.0 0.1 0.0055 17.0 0.1 2.4 1 1 0 2 2 2 1 RWD domain PP1c_bdg PF10488.9 EFC39319.1 - 0.034 13.6 8.1 0.046 13.2 8.1 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region DUF755 PF05501.11 EFC39319.1 - 0.06 13.6 9.7 0.097 12.9 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Prok-E2_B PF14461.6 EFC39319.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B Cwf_Cwc_15 PF04889.12 EFC39319.1 - 0.3 10.8 13.9 0.41 10.3 13.9 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DDHD PF02862.17 EFC39319.1 - 0.53 10.4 4.7 0.72 10.0 4.7 1.2 1 0 0 1 1 1 0 DDHD domain PAF PF15715.5 EFC39319.1 - 1.8 9.1 13.3 2.7 8.6 13.3 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain BING4CT PF08149.11 EFC39322.1 - 7.9e-32 108.9 1.4 5.9e-29 99.7 0.0 3.2 3 0 0 3 3 3 2 BING4CT (NUC141) domain WD40 PF00400.32 EFC39322.1 - 1.1e-06 29.2 4.3 0.0016 19.2 0.0 4.7 5 0 0 5 5 5 1 WD domain, G-beta repeat MMS1_N PF10433.9 EFC39322.1 - 0.00023 19.9 0.0 0.00059 18.6 0.0 1.5 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term ANAPC4_WD40 PF12894.7 EFC39322.1 - 0.00091 19.5 0.0 22 5.5 0.0 4.2 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Metallophos PF00149.28 EFC39323.1 - 1.2e-20 74.9 2.3 1.9e-20 74.3 2.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFC39323.1 - 1.2e-12 48.2 2.2 1.9e-12 47.6 0.1 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFC39323.1 - 4.5e-12 46.7 0.1 1.6e-11 44.9 0.1 2.0 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 EFC39323.1 - 0.00021 21.5 0.0 0.00081 19.6 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD_N PF16655.5 EFC39323.1 - 0.067 13.7 0.2 0.31 11.6 0.0 2.2 2 1 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain Soyouz_module PF14313.6 EFC39323.1 - 0.13 12.0 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) adh_short PF00106.25 EFC39324.1 - 5.2e-10 39.1 0.6 4.5e-09 36.1 0.8 2.3 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39324.1 - 2.3e-05 24.1 0.1 7.5e-05 22.4 0.1 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39324.1 - 0.00012 22.0 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 KR domain EF1G PF00647.19 EFC39324.1 - 0.057 13.5 0.1 0.19 11.8 0.1 1.9 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain DUF3830 PF12903.7 EFC39324.1 - 0.15 11.8 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) RWP-RK PF02042.15 EFC39325.1 - 7.5e-07 29.0 0.2 1.5e-06 28.1 0.2 1.5 1 0 0 1 1 1 1 RWP-RK domain Pinin_SDK_memA PF04696.13 EFC39325.1 - 0.11 12.5 2.0 0.21 11.6 1.7 1.5 1 1 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF3053 PF11254.8 EFC39326.1 - 0.02 14.5 0.5 0.025 14.1 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) DUF1477 PF07346.11 EFC39326.1 - 0.044 14.0 0.2 0.098 12.9 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1477) Anti-adapt_IraP PF10796.9 EFC39326.1 - 0.19 12.3 4.7 0.18 12.4 0.9 2.4 2 1 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein YtxC PF08812.11 EFC39327.1 - 0.0067 16.1 0.3 0.0081 15.8 0.3 1.0 1 0 0 1 1 1 1 YtxC-like family Bac_DNA_binding PF00216.21 EFC39327.1 - 0.016 15.4 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial DNA-binding protein lci PF12197.8 EFC39327.1 - 0.13 12.1 1.7 1.8 8.4 0.7 2.2 2 0 0 2 2 2 0 Bacillus cereus group antimicrobial protein Lactonase PF10282.9 EFC39328.1 - 0.066 12.5 0.0 0.12 11.6 0.0 1.4 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Vps39_2 PF10367.9 EFC39329.1 - 5.2e-24 84.8 1.1 5.2e-24 84.8 1.1 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EFC39329.1 - 0.002 18.0 7.5 0.011 15.7 0.1 4.2 3 1 0 3 3 3 1 Region in Clathrin and VPS DUF2175 PF09943.9 EFC39329.1 - 0.0066 16.7 0.8 0.049 13.9 0.1 2.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) DUF2685 PF10886.8 EFC39329.1 - 0.097 12.9 0.1 3.1 8.1 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2685) Vps39_1 PF10366.9 EFC39329.1 - 4.1 7.7 6.8 1.2 9.5 1.0 3.0 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 Zn_clus PF00172.18 EFC39330.1 - 2.2e-08 34.1 9.8 2.2e-08 34.1 9.8 1.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Myosin_TH1 PF06017.13 EFC39332.1 - 1.6e-20 73.6 1.6 5.7e-11 42.4 0.9 3.2 1 1 1 2 2 2 2 Unconventional myosin tail, actin- and lipid-binding RUN PF02759.19 EFC39332.1 - 4.5e-12 46.1 11.8 8.6e-09 35.5 0.0 4.3 4 1 0 4 4 4 2 RUN domain PH PF00169.29 EFC39332.1 - 2.1e-10 41.0 9.6 4.4e-06 27.1 0.5 4.7 4 0 0 4 4 4 2 PH domain ESSS PF10183.9 EFC39333.1 - 1.4e-07 31.7 0.0 2.5e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) FA_desaturase PF00487.24 EFC39333.1 - 0.0024 17.8 1.0 0.0027 17.6 1.0 1.1 1 0 0 1 1 1 1 Fatty acid desaturase MCRS_N PF13325.6 EFC39334.1 - 2.4e-57 194.2 0.7 3.6e-57 193.6 0.7 1.3 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein Tsp45I PF06300.12 EFC39335.1 - 0.006 16.1 0.6 0.0098 15.5 0.4 1.4 1 1 0 1 1 1 1 Tsp45I type II restriction enzyme Pox_G5 PF04599.12 EFC39335.1 - 0.032 13.2 3.5 0.042 12.9 3.5 1.3 1 0 0 1 1 1 0 Poxvirus G5 protein DUF4710 PF15828.5 EFC39335.1 - 0.56 10.4 5.1 1.7 8.8 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4710) Kinesin PF00225.23 EFC39336.1 - 7.6e-109 363.7 2.1 7.6e-109 363.7 2.1 3.1 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC39336.1 - 3.2e-27 95.3 0.3 3.2e-27 95.3 0.3 3.1 3 0 0 3 3 3 1 Microtubule binding HpaB_N PF11794.8 EFC39336.1 - 0.071 12.8 0.7 0.41 10.3 0.0 2.5 3 0 0 3 3 3 0 4-hydroxyphenylacetate 3-hydroxylase N terminal HisKA_3 PF07730.13 EFC39336.1 - 0.15 12.6 1.9 0.4 11.2 0.3 2.6 2 0 0 2 2 2 0 Histidine kinase Pdase_M17_N2 PF18295.1 EFC39336.1 - 0.99 9.7 5.2 15 5.9 0.3 3.2 3 0 0 3 3 3 0 M17 aminopeptidase N-terminal domain 2 QRPTase_C PF01729.19 EFC39336.1 - 1.4 8.6 7.3 1 9.1 1.8 2.7 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain ECH_2 PF16113.5 EFC39337.1 - 7.9e-76 255.7 0.0 1.2e-75 255.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFC39337.1 - 1.5e-17 63.8 0.0 4.4e-17 62.2 0.0 1.7 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Pepdidase_M14_N PF18027.1 EFC39337.1 - 4.6e-16 59.1 1.7 1e-15 58.0 1.7 1.6 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain Peptidase_M14 PF00246.24 EFC39337.1 - 4.6e-12 46.3 0.0 1.3e-11 44.8 0.0 1.7 1 1 0 1 1 1 1 Zinc carboxypeptidase AstE_AspA PF04952.14 EFC39337.1 - 0.032 13.3 0.0 0.052 12.6 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family DUF3430 PF11912.8 EFC39338.1 - 0.0012 19.0 15.0 0.0081 16.2 15.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3430) Cyt-b5 PF00173.28 EFC39339.1 - 2.6e-15 56.3 0.1 3.1e-15 56.1 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LMWPc PF01451.21 EFC39340.1 - 2.6e-38 131.6 0.0 2.9e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase R3H PF01424.22 EFC39341.1 - 0.00095 19.1 0.0 0.0054 16.7 0.0 2.2 2 0 0 2 2 2 1 R3H domain MRI PF15325.6 EFC39341.1 - 2.7 9.1 9.0 2.5 9.2 0.1 3.1 3 0 0 3 3 3 0 Modulator of retrovirus infection PH PF00169.29 EFC39342.1 - 1.6e-07 31.8 2.9 7.3e-07 29.7 0.1 3.2 3 2 1 4 4 3 1 PH domain PH_8 PF15409.6 EFC39342.1 - 0.0014 18.9 0.3 0.0063 16.8 0.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain CENP-F_leu_zip PF10473.9 EFC39342.1 - 0.0033 17.4 13.0 0.0033 17.4 13.0 2.8 3 0 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FAM209 PF15206.6 EFC39342.1 - 0.014 15.2 4.8 0.03 14.1 1.2 2.8 1 1 2 3 3 3 0 FAM209 family Baculo_PEP_C PF04513.12 EFC39342.1 - 0.021 14.9 6.0 0.69 10.0 0.8 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Dad1 PF08649.10 EFC39342.1 - 0.1 12.8 0.6 0.1 12.8 0.6 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad1 DUF1664 PF07889.12 EFC39342.1 - 0.23 11.5 15.9 2.9 8.0 0.8 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 EFC39342.1 - 0.43 11.1 27.2 0.16 12.5 13.0 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region PH_11 PF15413.6 EFC39342.1 - 0.85 10.1 0.1 0.85 10.1 0.1 3.8 3 2 1 4 4 4 0 Pleckstrin homology domain bZIP_1 PF00170.21 EFC39342.1 - 2.3 8.4 19.4 0.04 14.0 4.1 4.1 2 2 2 4 4 4 0 bZIP transcription factor DUF812 PF05667.11 EFC39342.1 - 6.1 5.6 29.1 12 4.7 29.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Spc7 PF08317.11 EFC39342.1 - 7.5 5.3 24.5 1.6 7.5 13.5 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein ZapB PF06005.12 EFC39342.1 - 7.8 7.0 31.6 0.17 12.3 13.5 4.4 3 2 2 5 5 5 0 Cell division protein ZapB Dpy-30 PF05186.13 EFC39344.1 - 6.4e-16 57.8 0.1 1.3e-15 56.8 0.1 1.5 1 0 0 1 1 1 1 Dpy-30 motif ADK PF00406.22 EFC39344.1 - 2.8e-10 40.5 0.2 3.8e-07 30.3 0.0 3.1 3 1 0 3 3 3 2 Adenylate kinase AAA_17 PF13207.6 EFC39344.1 - 5.2e-07 30.2 13.3 1.3e-05 25.7 0.9 3.5 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.6 EFC39344.1 - 0.00055 20.1 6.9 0.0016 18.6 0.0 3.5 2 1 1 3 3 3 1 AAA domain G-alpha PF00503.20 EFC39344.1 - 0.00074 18.8 1.3 0.00074 18.8 1.3 1.9 2 0 0 2 2 2 1 G-protein alpha subunit BUD22 PF09073.10 EFC39344.1 - 0.0012 18.3 7.1 0.0012 18.3 7.1 2.2 2 0 0 2 2 2 1 BUD22 AAA_24 PF13479.6 EFC39344.1 - 0.0024 17.6 0.2 0.007 16.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain DDHD PF02862.17 EFC39344.1 - 0.076 13.2 6.0 2.5 8.2 0.9 2.2 2 0 0 2 2 2 0 DDHD domain AAA_22 PF13401.6 EFC39344.1 - 0.11 12.8 2.8 2.5 8.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain TERB2 PF15101.6 EFC39344.1 - 3.3 7.7 18.3 0.63 10.1 4.9 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 SET PF00856.28 EFC39344.1 - 3.6 7.9 5.7 15 5.9 0.3 2.7 3 0 0 3 3 3 0 SET domain PseudoU_synth_2 PF00849.22 EFC39346.1 - 1.8e-12 47.6 0.0 3.2e-12 46.8 0.0 1.5 1 1 0 1 1 1 1 RNA pseudouridylate synthase 2OG-FeII_Oxy_2 PF13532.6 EFC39347.1 - 4.4e-10 40.1 0.0 5.8e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C3HC4_3 PF13920.6 EFC39348.1 - 4.2e-16 58.5 11.0 6.6e-16 57.9 11.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC39348.1 - 1.1e-08 34.7 11.6 2e-08 34.0 11.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SPRY PF00622.28 EFC39348.1 - 3.3e-06 27.2 0.1 5.7e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-RING_2 PF13639.6 EFC39348.1 - 0.00014 22.1 11.9 0.00024 21.4 11.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC39348.1 - 0.007 16.2 13.1 0.014 15.2 13.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC39348.1 - 0.014 15.3 12.6 0.029 14.3 12.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain GAS PF13851.6 EFC39348.1 - 0.026 13.9 17.3 0.049 13.0 17.3 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Cgr1 PF03879.14 EFC39348.1 - 0.3 11.5 6.6 0.54 10.6 6.6 1.3 1 0 0 1 1 1 0 Cgr1 family zf-RING_4 PF14570.6 EFC39348.1 - 0.42 10.5 8.3 0.9 9.4 8.3 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RGS PF00615.19 EFC39349.1 - 5.5e-09 36.3 1.2 0.0013 19.0 0.3 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain WD40 PF00400.32 EFC39351.1 - 0.00041 21.1 6.0 5 8.2 0.2 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat RSN1_7TM PF02714.15 EFC39352.1 - 2.7e-29 102.4 28.8 2.7e-29 102.4 28.8 2.4 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFC39352.1 - 5.8e-07 29.4 0.6 5.8e-07 29.4 0.6 6.4 6 2 2 8 8 8 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 EFC39352.1 - 4.6e-06 27.0 1.1 1.5e-05 25.3 1.1 1.9 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF4834 PF16118.5 EFC39352.1 - 0.0092 16.9 1.0 0.0092 16.9 1.0 5.8 7 0 0 7 7 7 1 Domain of unknown function (DUF4834) DUF4820 PF16091.5 EFC39352.1 - 0.027 13.8 1.5 0.048 13.0 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Dynamin_N PF00350.23 EFC39352.1 - 0.094 12.8 0.9 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Dynamin family Shisa PF13908.6 EFC39352.1 - 0.16 12.2 0.0 0.16 12.2 0.0 2.9 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator FAM176 PF14851.6 EFC39352.1 - 4.6 6.9 10.5 2 8.1 0.7 3.2 3 0 0 3 3 3 0 FAM176 family SAM_2 PF07647.17 EFC39353.1 - 0.0039 17.3 0.0 0.01 15.9 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ish1 PF10281.9 EFC39353.1 - 0.029 14.6 1.2 0.12 12.7 1.2 2.1 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein SAM_1 PF00536.30 EFC39353.1 - 0.035 14.5 0.0 0.075 13.5 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) p450 PF00067.22 EFC39354.1 - 2.6e-61 207.8 1.0 3.4e-61 207.4 1.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Nodulin-like PF06813.13 EFC39355.1 - 1.3e-28 100.2 9.7 1.3e-28 100.2 9.7 2.2 2 0 0 2 2 2 1 Nodulin-like MFS_1 PF07690.16 EFC39355.1 - 1.3e-27 96.7 31.7 6.5e-15 54.9 13.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex14_N PF04695.13 EFC39355.1 - 0.0063 17.2 0.6 0.46 11.1 0.4 2.5 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4116 PF13475.6 EFC39357.1 - 5.8e-16 57.9 24.2 1.3e-05 24.8 1.8 6.2 5 2 3 8 8 8 5 Domain of unknown function (DUF4116) SMI1_KNR4 PF09346.10 EFC39357.1 - 0.00091 19.6 0.0 0.0023 18.4 0.0 1.8 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) SUKH_5 PF14567.6 EFC39357.1 - 0.0058 16.4 0.2 0.03 14.1 0.0 2.3 2 0 0 2 2 2 1 SMI1-KNR4 cell-wall PX PF00787.24 EFC39358.1 - 2.6e-08 33.8 1.2 6e-08 32.7 1.2 1.6 1 0 0 1 1 1 1 PX domain F-box PF00646.33 EFC39358.1 - 0.027 14.4 0.0 0.054 13.4 0.0 1.5 1 0 0 1 1 1 0 F-box domain DUF2482 PF10655.9 EFC39358.1 - 7.4 7.2 8.7 0.41 11.2 1.1 2.8 3 0 0 3 3 3 0 Hypothetical protein of unknown function (DUF2482) Shisa PF13908.6 EFC39359.1 - 0.0031 17.8 0.2 0.0053 17.0 0.2 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Peptidase_M56 PF05569.11 EFC39359.1 - 0.038 13.2 0.0 0.076 12.2 0.0 1.4 1 0 0 1 1 1 0 BlaR1 peptidase M56 EphA2_TM PF14575.6 EFC39359.1 - 0.062 14.2 0.1 0.22 12.4 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain KH_1 PF00013.29 EFC39360.1 - 1.9e-09 37.2 0.1 4.2e-09 36.1 0.1 1.6 1 0 0 1 1 1 1 KH domain LETM1 PF07766.13 EFC39360.1 - 0.05 12.9 0.1 0.11 11.9 0.1 1.5 1 0 0 1 1 1 0 LETM1-like protein PB1 PF00564.24 EFC39361.1 - 0.021 14.7 0.2 0.066 13.1 0.0 1.9 2 0 0 2 2 2 0 PB1 domain BUD22 PF09073.10 EFC39361.1 - 0.83 8.9 26.6 1.1 8.5 26.6 1.1 1 0 0 1 1 1 0 BUD22 Pan3_PK PF18101.1 EFC39362.1 - 7e-11 42.3 0.3 1.3e-10 41.4 0.3 1.5 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 EFC39362.1 - 2.2e-06 27.2 0.0 1.1e-05 25.0 0.0 1.9 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39362.1 - 0.032 13.5 0.0 0.11 11.7 0.0 1.8 1 1 1 2 2 2 0 Protein tyrosine kinase Serpin PF00079.20 EFC39363.1 - 9.4e-70 235.8 9.8 1e-69 235.7 9.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RCC1_2 PF13540.6 EFC39364.1 - 6.8e-12 44.9 10.7 0.00013 21.6 0.0 5.8 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC39364.1 - 0.0018 18.9 8.5 0.25 12.0 0.5 4.4 5 1 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat PHTB1_N PF14727.6 EFC39364.1 - 0.026 13.9 0.0 0.92 8.8 0.0 2.1 2 0 0 2 2 2 0 PTHB1 N-terminus Y_phosphatase3 PF13350.6 EFC39365.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family VRP3 PF03536.15 EFC39366.1 - 0.004 16.7 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 2 Salmonella virulence-associated 28kDa protein PYST-C1 PF09690.10 EFC39366.1 - 7.3 6.4 16.8 1.6 8.6 12.7 2.0 2 0 0 2 2 2 0 Plasmodium yoelii subtelomeric region (PYST-C1) SAM_3 PF18016.1 EFC39367.1 - 0.0071 16.1 2.4 0.25 11.2 0.0 3.5 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) Ish1 PF10281.9 EFC39367.1 - 0.055 13.8 0.3 0.055 13.8 0.3 2.6 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein DUF1508 PF07411.12 EFC39368.1 - 0.036 13.9 0.2 0.097 12.5 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1508) DHR-2 PF06920.13 EFC39369.1 - 3.7e-76 256.9 38.5 1.1e-43 149.7 14.2 5.8 5 1 0 5 5 5 3 Dock homology region 2 DOCK-C2 PF14429.6 EFC39369.1 - 3.5e-22 79.2 2.8 1.8e-21 76.9 2.8 2.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DUF5638 PF18688.1 EFC39369.1 - 0.22 11.8 7.9 26 5.2 0.5 4.7 3 0 0 3 3 3 0 Family of unknown function (DUF5638) Pkinase PF00069.25 EFC39370.1 - 3.6e-69 233.1 0.0 5.9e-69 232.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39370.1 - 1.4e-27 96.6 2.2 3.1e-27 95.5 0.1 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC39370.1 - 0.00014 21.0 0.2 0.00014 21.0 0.2 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFC39370.1 - 0.00038 19.9 0.1 0.00065 19.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4611 PF15387.6 EFC39370.1 - 0.42 10.9 5.8 57 4.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) RGS PF00615.19 EFC39371.1 - 2.3e-09 37.6 7.7 4.1e-09 36.7 7.7 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF4420 PF14390.6 EFC39371.1 - 0.0022 17.3 0.1 0.0043 16.4 0.1 1.4 1 0 0 1 1 1 1 Putative PD-(D/E)XK family member, (DUF4420) C12orf66_like PF09404.10 EFC39371.1 - 0.005 15.7 0.1 0.0059 15.5 0.1 1.2 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like NicO PF03824.16 EFC39371.1 - 0.033 13.5 0.0 0.059 12.7 0.0 1.3 1 1 0 1 1 1 0 High-affinity nickel-transport protein COX16 PF14138.6 EFC39371.1 - 5.5 7.6 6.4 6.7e+02 0.9 6.4 2.9 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 RCC1_2 PF13540.6 EFC39372.1 - 1.4e-18 66.1 5.5 0.00042 20.0 0.1 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC39372.1 - 4.4e-07 30.4 3.2 0.011 16.3 0.0 5.0 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat CCDC158 PF15921.5 EFC39373.1 - 0.11 10.3 0.0 0.13 10.0 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 DUF3551 PF12071.8 EFC39374.1 - 0.091 12.8 0.3 0.091 12.8 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3551) PhoLip_ATPase_C PF16212.5 EFC39376.1 - 3.4e-42 144.9 12.2 3.4e-42 144.9 12.2 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC39376.1 - 4.9e-26 90.2 8.5 1.4e-25 88.8 8.5 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFC39376.1 - 2.3e-08 33.8 0.0 7e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase DUF4360 PF14273.6 EFC39376.1 - 0.017 15.0 1.9 0.017 15.0 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4360) ChapFlgA_N PF17656.1 EFC39376.1 - 0.15 12.3 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 FlgA N-terminal domain PhoLip_ATPase_C PF16212.5 EFC39377.1 - 1.9e-85 286.6 22.2 1.9e-85 286.6 22.2 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC39377.1 - 8.9e-24 83.0 9.1 8.9e-24 83.0 9.1 2.4 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFC39377.1 - 2.5e-11 43.4 0.0 6.2e-11 42.1 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFC39377.1 - 3.7e-11 43.0 0.2 3.5e-10 39.8 0.0 2.6 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC39377.1 - 6.1e-10 39.7 0.0 1.8e-06 28.4 0.0 3.1 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase DUF4360 PF14273.6 EFC39377.1 - 0.015 15.1 1.7 0.027 14.3 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4360) APH PF01636.23 EFC39378.1 - 9.8e-07 28.9 0.2 1.6e-06 28.3 0.2 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 EFC39378.1 - 1e-05 25.1 0.0 1.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Choline_kinase PF01633.20 EFC39378.1 - 1.4e-05 24.8 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 EFC39378.1 - 0.025 14.2 0.0 0.046 13.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family DotA PF11388.8 EFC39378.1 - 0.036 14.3 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 Phagosome trafficking protein DotA Baculo_ODV-E27 PF05314.11 EFC39378.1 - 0.037 13.2 0.3 0.061 12.5 0.3 1.3 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Pkinase_fungal PF17667.1 EFC39378.1 - 0.04 12.7 0.0 0.06 12.1 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Androgen_recep PF02166.16 EFC39379.1 - 0.0044 15.9 0.6 0.0063 15.4 0.6 1.2 1 0 0 1 1 1 1 Androgen receptor Ribosomal_60s PF00428.19 EFC39379.1 - 0.14 12.7 0.4 0.36 11.4 0.4 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Actin PF00022.19 EFC39380.1 - 2.6e-140 467.7 0.0 1e-139 465.7 0.0 1.7 1 1 0 1 1 1 1 Actin OST3_OST6 PF04756.13 EFC39382.1 - 2.3e-12 46.9 0.6 2.7e-12 46.6 0.6 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family ADH_zinc_N_2 PF13602.6 EFC39383.1 - 1.7e-11 45.3 0.0 2.8e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC39383.1 - 5.4e-10 39.1 0.1 9.9e-09 35.1 0.0 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC39383.1 - 6.2e-10 39.2 0.0 1.2e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EFC39383.1 - 5.7e-06 26.3 0.0 7.6e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) ADH_N_2 PF16884.5 EFC39383.1 - 0.003 17.4 0.0 0.0062 16.4 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Eno-Rase_NADH_b PF12242.8 EFC39383.1 - 0.011 15.5 0.1 0.024 14.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADK PF00406.22 EFC39384.1 - 6.6e-54 182.1 0.0 7.9e-54 181.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFC39384.1 - 3.6e-24 85.7 0.0 6.3e-24 84.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 EFC39384.1 - 8.3e-15 54.5 0.0 1.5e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid Hydin_ADK PF17213.3 EFC39384.1 - 1.2e-06 29.0 0.0 4.6e-06 27.0 0.0 1.8 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain AAA_33 PF13671.6 EFC39384.1 - 1.2e-05 25.6 0.0 1.9e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC39384.1 - 0.0034 17.9 0.0 0.011 16.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFC39384.1 - 0.017 14.8 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase PARG_cat PF05028.14 EFC39385.1 - 2.5e-99 332.8 0.0 3.2e-99 332.4 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Ca_chan_IQ PF08763.11 EFC39385.1 - 0.092 13.0 0.1 2.9 8.1 0.0 2.9 2 1 1 3 3 3 0 Voltage gated calcium channel IQ domain NUDIX PF00293.28 EFC39386.1 - 2.7e-06 27.4 0.0 1.5e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 NUDIX domain Beta-Casp PF10996.8 EFC39387.1 - 7.1e-32 110.0 0.0 2.6e-31 108.1 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.27 EFC39387.1 - 4.1e-22 79.2 0.3 6.1e-22 78.6 0.3 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 EFC39387.1 - 1.2e-19 70.6 0.1 1e-18 67.5 0.0 2.6 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EFC39387.1 - 1.3e-16 60.2 0.0 2.8e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain CPSF73-100_C PF11718.8 EFC39387.1 - 1.4e-16 60.7 1.6 9.6e-16 58.0 1.0 2.6 2 1 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Lactamase_B_2 PF12706.7 EFC39387.1 - 1.5e-07 31.1 0.4 4e-07 29.7 0.4 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC39387.1 - 6.3e-05 22.9 0.2 0.00034 20.5 0.2 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 EFC39387.1 - 0.0049 16.1 0.0 0.013 14.7 0.0 1.7 2 0 0 2 2 2 1 Putative beta-lactamase-like family DUF229 PF02995.17 EFC39388.1 - 1.1e-37 129.8 14.8 5.7e-37 127.5 14.8 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF229) Sigma_reg_N PF13800.6 EFC39388.1 - 0.018 15.3 2.1 0.13 12.6 0.0 2.9 2 0 0 2 2 2 0 Sigma factor regulator N-terminal ABC2_membrane_3 PF12698.7 EFC39388.1 - 0.05 12.7 4.3 0.11 11.6 4.3 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein Orf78 PF06024.12 EFC39388.1 - 0.051 13.9 0.1 0.051 13.9 0.1 2.6 3 0 0 3 3 3 0 Orf78 (ac78) SH2 PF00017.24 EFC39389.1 - 1.4e-07 31.5 0.1 3.3e-06 27.1 0.1 2.7 1 1 1 2 2 2 2 SH2 domain Cbl_N2 PF02761.14 EFC39389.1 - 0.0045 17.7 1.5 0.033 14.9 0.3 2.7 2 0 0 2 2 2 1 CBL proto-oncogene N-terminus, EF hand-like domain Rer1 PF03248.13 EFC39390.1 - 2e-63 213.2 0.2 2.4e-63 212.9 0.2 1.1 1 0 0 1 1 1 1 Rer1 family DUF1538 PF07556.11 EFC39390.1 - 0.2 10.9 2.7 0.27 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1538) Pkinase PF00069.25 EFC39391.1 - 1.7e-19 70.2 0.2 2.3e-19 69.8 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39391.1 - 3.7e-11 42.8 0.2 4.7e-11 42.5 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ELO PF01151.18 EFC39392.1 - 6.7e-55 186.3 25.6 7.8e-55 186.1 25.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Lig_chan PF00060.26 EFC39392.1 - 0.06 13.2 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Ligand-gated ion channel zf-Di19 PF05605.12 EFC39393.1 - 0.036 14.4 0.1 0.12 12.7 0.1 1.9 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding ABC_trans_N PF14510.6 EFC39393.1 - 7.8 7.2 5.9 2.6 8.7 0.5 2.7 2 1 0 2 2 2 0 ABC-transporter N-terminal DUF3560 PF12083.8 EFC39393.1 - 9.3 6.4 10.0 2.4 8.3 0.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3560) EF-hand_7 PF13499.6 EFC39394.1 - 1.4e-20 73.5 7.0 6.8e-12 45.7 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC39394.1 - 2.8e-17 60.9 14.0 1.2e-08 33.9 0.8 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC39394.1 - 3.8e-16 57.6 13.4 1e-07 31.3 0.3 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EFC39394.1 - 3.4e-13 49.2 2.8 2.4e-10 40.1 0.1 3.9 2 2 3 5 5 5 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC39394.1 - 1.5e-08 33.8 8.9 1.3e-06 27.6 0.5 3.0 3 0 0 3 3 3 2 EF hand HTH_57 PF18679.1 EFC39394.1 - 0.0077 16.5 0.3 1.1 9.6 0.0 2.3 1 1 1 2 2 2 1 ThcOx helix turn helix domain SPARC_Ca_bdg PF10591.9 EFC39394.1 - 0.028 14.7 3.2 1.9 8.8 0.2 2.9 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 EFC39394.1 - 0.053 14.4 0.3 0.88 10.5 0.1 2.5 2 1 0 2 2 2 0 EF-hand domain EF-hand_4 PF12763.7 EFC39394.1 - 0.073 13.0 4.9 8.4 6.4 0.2 3.2 1 1 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EFC39394.1 - 0.081 12.8 2.0 9.9 6.0 0.1 3.0 2 2 1 3 3 3 0 Caleosin related protein Dockerin_1 PF00404.18 EFC39394.1 - 0.18 12.0 2.6 14 5.9 0.0 3.0 3 1 1 4 4 4 0 Dockerin type I domain DUF3887 PF13026.6 EFC39394.1 - 0.21 12.4 5.0 11 7.0 0.2 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF3887) Mito_carr PF00153.27 EFC39395.1 - 9.8e-49 163.2 3.5 5.7e-17 61.4 0.1 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein MRP-L46 PF11788.8 EFC39396.1 - 1.8e-06 28.7 1.8 4.5e-06 27.4 1.8 1.7 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 Condensation PF00668.20 EFC39397.1 - 0.0011 17.8 1.1 0.0011 17.8 1.1 2.2 2 0 0 2 2 2 2 Condensation domain Transferase PF02458.15 EFC39397.1 - 0.0013 17.4 0.2 0.0041 15.8 0.2 1.7 1 1 0 1 1 1 1 Transferase family SPRY PF00622.28 EFC39398.1 - 1.3e-10 41.4 0.5 2.6e-09 37.2 0.1 2.5 2 0 0 2 2 2 1 SPRY domain Ank_3 PF13606.6 EFC39398.1 - 5.1e-09 35.6 1.8 0.0029 18.0 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EFC39398.1 - 9.9e-07 29.3 0.1 1.8e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC39398.1 - 4.2e-06 27.2 0.1 0.016 15.8 0.1 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC39398.1 - 7.1e-06 26.2 0.2 0.0015 18.8 0.3 2.7 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 EFC39398.1 - 7.2e-06 26.2 2.5 0.00031 21.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Vma12 PF11712.8 EFC39399.1 - 1.8e-09 37.8 0.0 2.9e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase MFS_2 PF13347.6 EFC39399.1 - 0.0054 15.4 0.0 0.0065 15.1 0.0 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein Polysacc_synt_C PF14667.6 EFC39399.1 - 0.048 13.7 1.9 0.066 13.3 1.9 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain GDP_Man_Dehyd PF16363.5 EFC39401.1 - 4e-48 164.5 0.5 3.7e-43 148.2 0.2 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC39401.1 - 1.5e-42 145.7 0.1 1.1e-37 129.8 0.0 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC39401.1 - 2.5e-09 36.7 0.3 3.7e-05 23.0 0.1 3.3 3 0 0 3 3 3 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFC39401.1 - 2.8e-09 36.4 0.7 5.7e-07 28.8 0.5 2.4 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC39401.1 - 0.00012 21.3 0.0 0.04 13.1 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 EFC39401.1 - 0.017 14.2 0.0 5.7 5.9 0.0 2.5 1 1 1 2 2 2 0 RmlD substrate binding domain DUF5315 PF17242.2 EFC39401.1 - 0.02 14.7 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 Disordered region of unknown function (DUF5315) Pkinase PF00069.25 EFC39402.1 - 1.1e-55 188.8 2.0 2e-55 188.0 2.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39402.1 - 9.6e-47 159.4 0.8 1.6e-46 158.7 0.8 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC39402.1 - 7.4e-05 21.7 0.9 0.00025 19.9 0.2 2.0 2 0 0 2 2 2 1 Fungal protein kinase Acetyltransf_1 PF00583.25 EFC39402.1 - 0.0019 18.4 0.0 0.0049 17.1 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Kinase-like PF14531.6 EFC39402.1 - 0.0035 16.7 0.1 0.018 14.4 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EFC39402.1 - 0.0035 16.4 0.1 0.0073 15.4 0.1 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 Acetyltransf_10 PF13673.7 EFC39402.1 - 0.012 15.5 0.0 0.038 13.9 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC39402.1 - 0.014 15.8 0.0 0.039 14.4 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Kdo PF06293.14 EFC39402.1 - 0.02 14.3 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC39402.1 - 0.19 11.7 0.0 0.47 10.3 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family UvrB_inter PF17757.1 EFC39403.1 - 0.046 13.9 0.0 0.15 12.2 0.0 2.0 1 0 0 1 1 1 0 UvrB interaction domain Pyr_redox_2 PF07992.14 EFC39404.1 - 6.6e-43 147.0 0.1 1e-42 146.4 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_5 PF13202.6 EFC39404.1 - 1.2e-11 43.6 2.8 4.6e-05 22.7 0.2 2.6 2 0 0 2 2 2 2 EF hand Pyr_redox PF00070.27 EFC39404.1 - 3.7e-11 43.4 0.6 7.4e-10 39.3 0.7 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 EFC39404.1 - 4.1e-11 41.6 1.5 0.00018 20.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC39404.1 - 1.1e-10 41.8 0.2 0.00082 19.8 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC39404.1 - 1.2e-08 34.2 1.3 0.0012 18.6 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFC39404.1 - 0.00013 21.7 0.1 0.29 11.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair Dockerin_1 PF00404.18 EFC39404.1 - 0.0016 18.6 0.1 0.009 16.2 0.2 2.3 1 1 1 2 2 2 2 Dockerin type I domain SPARC_Ca_bdg PF10591.9 EFC39404.1 - 0.013 15.8 3.2 2.6 8.4 0.1 2.9 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC39404.1 - 0.023 14.7 0.1 17 5.5 0.0 3.4 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand PBP_sp32 PF07222.12 EFC39405.1 - 7.1 6.0 18.7 0.37 10.2 0.3 3.2 2 1 1 3 3 3 0 Proacrosin binding protein sp32 EGF_2 PF07974.13 EFC39406.1 - 2.7e-143 465.9 1047.5 5.7e-05 23.4 6.1 66.2 64 2 2 66 66 66 64 EGF-like domain FMO-like PF00743.19 EFC39407.1 - 3.6e-45 154.4 0.0 4.9e-45 153.9 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFC39407.1 - 4.3e-21 75.5 0.0 8.8e-18 64.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC39407.1 - 3.3e-12 46.2 0.0 3.2e-10 39.7 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFC39407.1 - 2.3e-11 43.5 0.0 1.3e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC39407.1 - 8e-07 29.5 0.2 0.00068 20.1 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC39407.1 - 4.4e-06 26.8 0.1 0.00016 21.8 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC39407.1 - 0.0077 15.8 0.0 3.2 7.2 0.0 3.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFC39407.1 - 0.018 15.0 0.1 7 6.6 0.1 3.6 3 1 0 3 3 3 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 EFC39407.1 - 0.021 14.2 0.0 5.6 6.2 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase SNase PF00565.17 EFC39408.1 - 6.4e-47 158.5 24.2 3.8e-12 46.6 0.2 6.5 5 1 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 EFC39408.1 - 2.6e-18 66.2 0.0 5.2e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 EFC39408.1 - 6.8e-06 25.5 0.9 1.4e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 Survival motor neuron protein (SMN) Kinesin_assoc PF16183.5 EFC39408.1 - 0.00014 22.1 1.3 0.00034 20.8 0.2 2.3 2 0 0 2 2 2 1 Kinesin-associated Agenet PF05641.12 EFC39408.1 - 0.0047 17.4 0.0 0.07 13.6 0.0 3.0 3 0 0 3 3 3 1 Agenet domain SH3_11 PF18103.1 EFC39408.1 - 0.053 13.7 0.1 11 6.3 0.0 3.1 3 0 0 3 3 3 0 Retroviral integrase C-terminal SH3 domain SAWADEE PF16719.5 EFC39408.1 - 0.093 12.7 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 SAWADEE domain Rtt106 PF08512.12 EFC39409.1 - 3.4e-23 81.9 0.3 7.8e-23 80.7 0.3 1.7 1 0 0 1 1 1 1 Histone chaperone Rttp106-like POB3_N PF17292.2 EFC39409.1 - 2.6e-22 79.0 1.8 2.4e-17 63.1 0.2 2.8 2 1 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 EFC39409.1 - 3e-17 62.3 0.0 1.2e-16 60.3 0.0 2.1 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) EF-hand_1 PF00036.32 EFC39410.1 - 2e-20 70.8 5.7 4.4e-06 25.8 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC39410.1 - 2.4e-16 59.9 1.6 2e-10 40.9 0.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC39410.1 - 2.7e-16 58.1 4.1 0.00033 20.3 0.1 4.0 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFC39410.1 - 1.4e-13 49.6 8.4 8e-05 22.0 0.0 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFC39410.1 - 7.6e-13 48.1 7.1 5.2e-06 26.2 0.1 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EFC39410.1 - 2e-05 24.5 2.9 0.39 10.7 0.1 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFC39410.1 - 0.14 12.5 0.1 5.2 7.5 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain Ninjurin PF04923.12 EFC39411.1 - 0.11 12.4 1.1 2.1 8.4 0.1 2.7 2 0 0 2 2 2 0 Ninjurin DUF883 PF05957.13 EFC39411.1 - 6.4 7.5 8.0 4.4 8.0 0.9 3.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) Sec7 PF01369.20 EFC39412.1 - 1e-42 145.9 2.7 5.6e-42 143.5 2.7 2.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EFC39412.1 - 1.6e-20 73.6 7.1 1.6e-20 73.6 7.1 5.5 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EFC39412.1 - 8.5e-15 54.4 6.7 8.5e-12 44.8 0.3 6.1 5 0 0 5 5 5 2 Domain of unknown function (DUF1981) DCB PF16213.5 EFC39412.1 - 4.7e-14 52.4 6.4 4.7e-14 52.4 6.4 4.3 4 1 1 5 5 5 1 Dimerisation and cyclophilin-binding domain of Mon2 LRR_4 PF12799.7 EFC39413.1 - 1.1e-08 35.2 26.4 0.00063 20.1 1.5 5.4 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC39413.1 - 0.00013 21.8 0.5 0.00013 21.8 0.5 2.3 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 EFC39413.1 - 0.00016 21.5 25.1 1.7 8.9 0.1 7.5 8 0 0 8 8 8 5 Leucine Rich repeat F-box PF00646.33 EFC39413.1 - 0.00094 19.0 0.2 0.0034 17.2 0.2 2.0 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 EFC39413.1 - 0.0038 16.9 25.6 0.009 15.8 3.9 4.4 2 2 1 3 3 3 1 Leucine rich repeat LRR_2 PF07723.13 EFC39413.1 - 0.024 15.3 1.7 4.1 8.2 0.2 3.3 2 0 0 2 2 2 0 Leucine Rich Repeat AHD PF17793.1 EFC39413.1 - 0.029 14.2 0.1 0.28 11.0 0.1 2.3 2 0 0 2 2 2 0 ANC1 homology domain (AHD) LRR_3 PF07725.12 EFC39413.1 - 0.79 9.7 3.9 0.97 9.4 1.1 2.8 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_4 PF12799.7 EFC39414.1 - 8.4e-17 61.0 40.1 1.4e-05 25.3 1.1 6.9 5 2 2 7 7 7 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC39414.1 - 1.7e-15 55.6 40.9 0.0073 16.3 0.8 9.5 11 0 0 11 11 11 7 Leucine Rich repeat LRR_8 PF13855.6 EFC39414.1 - 1.3e-10 40.9 40.2 7.5e-05 22.4 9.7 6.3 4 1 3 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 EFC39414.1 - 3.3e-06 26.7 8.8 0.14 11.7 2.7 3.8 1 1 1 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EFC39414.1 - 0.0001 22.3 31.2 0.34 11.6 0.5 8.6 7 3 0 7 7 7 2 Leucine Rich Repeat CRT-like PF08627.10 EFC39415.1 - 1.1e-19 70.6 25.9 1.4e-19 70.2 25.9 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like Toxin_21 PF08091.11 EFC39415.1 - 0.38 10.7 3.6 1.1 9.3 3.6 1.7 1 0 0 1 1 1 0 Spider insecticidal peptide DUF5406 PF17400.2 EFC39416.1 - 0.11 12.9 2.5 0.34 11.3 2.5 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5406) ABC2_membrane PF01061.24 EFC39417.1 - 7.8e-40 136.5 22.5 1.1e-39 136.0 22.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC39417.1 - 7.2e-27 94.6 0.3 3.7e-26 92.3 0.1 2.4 3 0 0 3 3 3 1 ABC transporter ABC2_membrane_3 PF12698.7 EFC39417.1 - 3.7e-06 26.3 17.1 3.7e-06 26.3 17.1 2.5 2 1 0 3 3 3 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFC39417.1 - 0.0015 18.4 0.2 0.093 12.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC39417.1 - 0.013 14.9 0.0 0.032 13.7 0.0 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC39417.1 - 0.017 15.0 0.1 0.017 15.0 0.1 2.5 3 0 0 3 3 3 0 RsgA GTPase AAA_22 PF13401.6 EFC39417.1 - 0.021 15.1 0.5 1 9.6 0.1 3.2 3 0 0 3 3 3 0 AAA domain AAA_35 PF14516.6 EFC39417.1 - 0.022 13.6 0.4 0.053 12.4 0.1 1.8 2 0 0 2 2 2 0 AAA-like domain OTU PF02338.19 EFC39418.1 - 7.3e-07 29.7 0.0 1.5e-06 28.7 0.0 1.6 2 0 0 2 2 2 1 OTU-like cysteine protease AAA_assoc_2 PF16193.5 EFC39418.1 - 0.068 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA C-terminal domain Inhibitor_I48 PF10467.9 EFC39419.1 - 0.029 14.3 0.0 0.049 13.5 0.0 1.3 1 1 0 1 1 1 0 Peptidase inhibitor clitocypin Arm PF00514.23 EFC39419.1 - 0.077 13.1 0.0 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Arm PF00514.23 EFC39420.1 - 1.3e-07 31.4 0.0 0.0077 16.2 0.0 3.7 3 1 0 3 3 3 2 Armadillo/beta-catenin-like repeat Ribonuc_red_sm PF00268.21 EFC39420.1 - 0.0059 16.1 0.4 0.016 14.7 0.2 1.8 1 1 1 2 2 2 1 Ribonucleotide reductase, small chain DUF3361 PF11841.8 EFC39420.1 - 0.026 14.5 9.1 0.13 12.2 1.5 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Atx10homo_assoc PF09759.9 EFC39420.1 - 0.039 14.0 4.8 0.38 10.8 0.6 3.0 2 1 2 4 4 4 0 Spinocerebellar ataxia type 10 protein domain CCD48 PF15799.5 EFC39420.1 - 0.1 10.9 0.1 0.18 10.1 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 HEAT PF02985.22 EFC39420.1 - 0.17 12.3 0.1 61 4.3 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat MSP7_C PF12948.7 EFC39420.1 - 2.8 8.6 6.5 2.5 8.8 0.4 2.8 1 1 2 3 3 3 0 MSP7-like protein C-terminal domain Oxysterol_BP PF01237.18 EFC39421.1 - 5.8e-44 150.4 3.5 1.2e-41 142.8 3.5 2.3 1 1 0 1 1 1 1 Oxysterol-binding protein Glyco_hydro2_C5 PF18565.1 EFC39422.1 - 0.002 17.9 0.2 0.0065 16.3 0.1 2.0 2 0 0 2 2 2 1 Glycoside hydrolase family 2 C-terminal domain 5 MG4 PF17789.1 EFC39422.1 - 0.08 13.1 3.4 0.18 12.0 0.4 2.7 2 1 0 2 2 2 0 Macroglobulin domain MG4 TMEM173 PF15009.6 EFC39422.1 - 0.14 11.3 1.8 0.17 11.0 0.5 1.7 2 0 0 2 2 2 0 Transmembrane protein 173 DUF2626 PF11117.8 EFC39423.1 - 0.13 13.0 0.8 0.24 12.2 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2626) HATPase_c PF02518.26 EFC39424.1 - 9.5e-24 84.1 0.0 1.5e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC39424.1 - 7.7e-13 48.3 0.2 2.4e-12 46.7 0.2 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EFC39424.1 - 0.0056 16.6 0.9 0.029 14.3 0.1 2.6 2 1 0 2 2 2 1 GHKL domain Antistasin PF02822.14 EFC39425.1 - 1.4e-12 48.0 25.1 3.1e-07 30.9 7.9 2.4 2 0 0 2 2 2 2 Antistasin family Ank_2 PF12796.7 EFC39426.1 - 4.8e-08 33.5 0.0 1.2e-07 32.2 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC39426.1 - 3e-07 30.2 0.1 0.0044 17.4 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC39426.1 - 3e-07 30.9 0.2 6.4e-05 23.4 0.1 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC39426.1 - 1.2e-06 28.7 0.2 0.016 15.5 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC39426.1 - 0.00026 21.3 0.1 0.16 12.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat MTD PF01993.18 EFC39426.1 - 0.092 12.1 0.0 15 4.8 0.0 2.5 3 0 0 3 3 3 0 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase LRR_6 PF13516.6 EFC39428.1 - 1.7e-27 93.1 46.4 0.0025 17.7 0.5 13.2 13 0 0 13 13 13 10 Leucine Rich repeat LRR_4 PF12799.7 EFC39428.1 - 4.5e-13 49.1 48.5 0.0028 18.0 0.1 8.9 2 1 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39428.1 - 4.2e-08 32.7 34.9 1.1 10.0 0.3 11.7 12 1 0 12 12 12 5 Leucine Rich Repeat LRR_8 PF13855.6 EFC39428.1 - 0.0038 17.0 49.4 3 7.7 6.4 9.1 3 2 5 8 8 8 4 Leucine rich repeat F-box-like PF12937.7 EFC39428.1 - 0.0099 15.8 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like YjcQ PF09639.10 EFC39428.1 - 0.31 11.3 6.9 1.5 9.0 0.2 4.2 3 2 1 4 4 4 0 YjcQ protein Asparaginase_2 PF01112.18 EFC39429.1 - 1.2e-77 260.9 0.3 3.4e-69 233.2 0.2 2.0 1 1 1 2 2 2 2 Asparaginase G_glu_transpept PF01019.21 EFC39429.1 - 0.00037 19.4 0.0 0.00054 18.9 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Thiolase_C PF02803.18 EFC39429.1 - 0.093 12.4 0.1 26 4.5 0.1 2.9 3 0 0 3 3 3 0 Thiolase, C-terminal domain DUF5633 PF18656.1 EFC39429.1 - 6.5 6.7 7.8 51 3.9 0.3 3.7 4 0 0 4 4 4 0 Family of unknown function (DUF5633) p450 PF00067.22 EFC39430.1 - 1.3e-60 205.5 0.8 2e-60 204.9 0.8 1.3 1 0 0 1 1 1 1 Cytochrome P450 Ras PF00071.22 EFC39431.1 - 1.6e-30 105.8 0.0 4.3e-30 104.4 0.0 1.8 1 0 0 1 1 1 1 Ras family BTB PF00651.31 EFC39431.1 - 5.3e-18 65.3 4.5 2.6e-13 50.2 0.3 3.5 3 0 0 3 3 3 2 BTB/POZ domain Roc PF08477.13 EFC39431.1 - 1.1e-11 45.0 0.0 3.2e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AF-4 PF05110.13 EFC39432.1 - 0.048 11.8 5.7 0.077 11.1 5.7 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TLD PF07534.16 EFC39433.1 - 3.2e-11 43.6 0.3 5.6e-11 42.8 0.3 1.4 1 0 0 1 1 1 1 TLD ZapB PF06005.12 EFC39433.1 - 0.071 13.6 0.5 0.12 12.8 0.5 1.3 1 0 0 1 1 1 0 Cell division protein ZapB FlxA PF14282.6 EFC39433.1 - 0.76 9.8 4.9 1.3 9.0 4.9 1.3 1 0 0 1 1 1 0 FlxA-like protein E2F_CC-MB PF16421.5 EFC39434.1 - 0.06 13.7 3.1 0.088 13.2 1.6 2.1 1 1 1 2 2 2 0 E2F transcription factor CC-MB domain zf-GRF PF06839.12 EFC39435.1 - 4.1e-21 74.8 26.4 2e-12 47.0 2.9 3.0 3 0 0 3 3 3 2 GRF zinc finger F-box-like PF12937.7 EFC39435.1 - 0.012 15.5 0.1 0.027 14.3 0.1 1.6 1 0 0 1 1 1 0 F-box-like SDA1 PF05285.12 EFC39435.1 - 0.029 13.8 21.6 0.045 13.2 21.6 1.3 1 0 0 1 1 1 0 SDA1 NIT PF08376.10 EFC39436.1 - 3.2e-23 83.4 0.0 4.7e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Nitrate and nitrite sensing Guanylate_cyc PF00211.20 EFC39436.1 - 5.2e-21 75.1 0.0 1.1e-20 74.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RGS PF00615.19 EFC39437.1 - 1.3e-09 38.4 1.4 1.3e-09 38.4 1.4 2.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain NHL PF01436.21 EFC39437.1 - 1.8e-05 24.5 0.1 5.8e-05 22.9 0.1 2.0 1 0 0 1 1 1 1 NHL repeat EGF_2 PF07974.13 EFC39437.1 - 2.8e-05 24.4 29.1 0.00089 19.6 6.0 2.6 2 0 0 2 2 2 2 EGF-like domain Kdo PF06293.14 EFC39437.1 - 0.0026 17.1 0.1 0.0049 16.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Cna_B PF05738.13 EFC39437.1 - 0.014 16.0 0.0 0.12 13.0 0.0 2.6 2 0 0 2 2 2 0 Cna protein B-type domain Eco57I PF07669.11 EFC39437.1 - 0.069 13.7 0.1 0.3 11.6 0.1 2.1 1 0 0 1 1 1 0 Eco57I restriction-modification methylase DUF4972 PF16342.5 EFC39437.1 - 0.35 10.5 2.4 0.69 9.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) Str_synth PF03088.16 EFC39438.1 - 1.7e-20 72.9 0.1 4.8e-20 71.5 0.1 1.8 1 0 0 1 1 1 1 Strictosidine synthase SGL PF08450.12 EFC39438.1 - 1.5e-17 64.0 0.0 7e-17 61.8 0.0 1.9 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EFC39438.1 - 0.00081 19.3 0.1 2.8 8.2 0.0 4.1 4 0 0 4 4 4 1 NHL repeat Arylesterase PF01731.20 EFC39438.1 - 0.0088 16.2 0.1 0.042 14.1 0.1 2.2 1 1 1 2 2 2 1 Arylesterase STT3_PglB_C PF18527.1 EFC39438.1 - 0.17 12.0 1.7 11 6.3 0.0 3.1 4 0 0 4 4 4 0 STT3/PglB C-terminal beta-barrel domain PQQ_3 PF13570.6 EFC39438.1 - 2 9.0 4.2 8.6 7.0 0.0 3.5 3 1 1 4 4 4 0 PQQ-like domain ABC2_membrane PF01061.24 EFC39439.1 - 4e-24 85.2 21.4 6.6e-24 84.5 21.4 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC39439.1 - 2.1e-11 44.5 0.0 6.5e-11 42.9 0.0 1.9 1 0 0 1 1 1 1 ABC transporter PDR_CDR PF06422.12 EFC39439.1 - 0.00067 19.5 1.7 0.0021 17.9 1.7 1.8 1 0 0 1 1 1 1 CDR ABC transporter ABC_ATPase PF09818.9 EFC39439.1 - 0.0035 16.2 0.2 0.0057 15.5 0.2 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class AAA_21 PF13304.6 EFC39439.1 - 0.0051 16.7 0.7 0.26 11.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SH3_1 PF00018.28 EFC39440.1 - 4.8e-34 115.7 0.4 6.2e-18 64.1 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EFC39440.1 - 3.9e-29 100.3 0.1 3.7e-14 52.3 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EFC39440.1 - 2.4e-22 78.3 0.0 2.2e-10 40.0 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain BAR PF03114.18 EFC39440.1 - 9e-16 58.2 13.4 1.6e-15 57.4 13.4 1.3 1 0 0 1 1 1 1 BAR domain BAR_3 PF16746.5 EFC39440.1 - 4.5e-10 39.6 16.0 6.9e-10 39.0 16.0 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Arfaptin PF06456.13 EFC39440.1 - 1.8e-08 34.2 11.7 2e-08 34.1 10.8 1.5 1 1 0 1 1 1 1 Arfaptin-like domain Med3 PF11593.8 EFC39440.1 - 0.05 12.8 7.4 0.071 12.3 7.4 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Dak1 PF02733.17 EFC39442.1 - 1.9e-73 247.1 0.3 6.3e-73 245.4 0.1 2.0 2 1 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 EFC39442.1 - 2.3e-35 122.1 0.0 3.8e-35 121.3 0.0 1.4 1 0 0 1 1 1 1 DAK2 domain ArfGap PF01412.18 EFC39444.1 - 2.9e-25 88.6 2.5 3.7e-25 88.3 1.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BTB PF00651.31 EFC39444.1 - 3.9e-09 36.7 5.3 1.8e-08 34.6 5.3 2.2 1 1 0 1 1 1 1 BTB/POZ domain ATG27 PF09451.10 EFC39445.1 - 1.7e-18 67.5 0.0 2.2e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFC39445.1 - 2.1e-07 30.3 0.1 1.5e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Mannose-6-phosphate receptor CIMR PF00878.18 EFC39445.1 - 0.0093 16.0 0.0 0.066 13.3 0.1 2.0 2 0 0 2 2 2 1 Cation-independent mannose-6-phosphate receptor repeat DUF1344 PF07076.11 EFC39445.1 - 0.15 11.9 0.2 4.3 7.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) Kelch_4 PF13418.6 EFC39446.1 - 4.5e-17 61.8 17.0 3.9e-07 30.0 0.3 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain BTB PF00651.31 EFC39446.1 - 3.6e-16 59.4 0.6 1.1e-14 54.7 0.0 3.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_3 PF13415.6 EFC39446.1 - 2.9e-14 52.9 4.4 6.7e-06 26.3 0.1 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC39446.1 - 5.9e-12 45.0 7.0 1.1e-06 28.1 0.1 4.3 5 0 0 5 5 5 2 Kelch motif RWD PF05773.22 EFC39446.1 - 3.9e-11 43.3 0.8 3.9e-11 43.3 0.8 2.5 2 0 0 2 2 2 1 RWD domain Kelch_2 PF07646.15 EFC39446.1 - 1.3e-10 40.8 5.5 1.5e-05 24.8 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFC39446.1 - 3.4e-10 39.7 10.5 0.00013 21.8 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 EFC39446.1 - 1.6e-07 31.4 13.4 0.0035 17.6 0.2 5.3 6 0 0 6 6 6 2 Kelch motif FlaC_arch PF05377.11 EFC39447.1 - 0.03 14.7 1.1 2.4 8.6 0.2 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Esterase_phd PF10503.9 EFC39448.1 - 2.6e-09 36.9 0.1 0.0008 19.0 0.0 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase Esterase PF00756.20 EFC39448.1 - 0.00083 19.1 0.1 0.017 14.7 0.1 2.3 2 1 0 2 2 2 1 Putative esterase Abhydrolase_2 PF02230.16 EFC39448.1 - 0.00099 19.0 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase zf-B_box PF00643.24 EFC39449.1 - 1.3e-08 34.8 8.7 1.3e-08 34.8 8.7 2.9 3 0 0 3 3 3 1 B-box zinc finger MATH PF00917.26 EFC39449.1 - 1.5e-08 34.8 0.1 1.5e-08 34.8 0.1 2.3 3 0 0 3 3 3 1 MATH domain zf-C3HC4_3 PF13920.6 EFC39449.1 - 2.4e-07 30.5 13.1 2.4e-07 30.5 13.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF1351 PF07083.11 EFC39449.1 - 0.00086 19.1 7.1 0.0028 17.5 7.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF1351) zf-RING_2 PF13639.6 EFC39449.1 - 0.0065 16.8 17.0 0.0065 16.8 17.0 2.4 2 0 0 2 2 2 1 Ring finger domain Pkinase PF00069.25 EFC39450.1 - 2.7e-46 158.1 0.2 5.7e-46 157.0 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39450.1 - 6.4e-36 124.0 0.2 7.3e-34 117.2 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC39450.1 - 1.1e-24 85.1 16.3 2.7e-05 24.0 0.3 11.1 11 0 0 11 11 11 6 NHL repeat EGF_2 PF07974.13 EFC39450.1 - 5.8e-07 29.8 55.4 0.0034 17.7 10.0 4.7 4 0 0 4 4 4 3 EGF-like domain Haspin_kinase PF12330.8 EFC39450.1 - 0.00029 19.9 0.2 0.00063 18.8 0.2 1.5 1 0 0 1 1 1 1 Haspin like kinase domain EGF PF00008.27 EFC39450.1 - 0.0013 19.0 31.3 0.13 12.6 3.3 4.0 3 0 0 3 3 3 2 EGF-like domain SGL PF08450.12 EFC39450.1 - 0.0027 17.3 0.1 1.4 8.4 0.0 4.2 4 0 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region Seadorna_VP7 PF07387.11 EFC39450.1 - 0.0055 15.8 0.1 0.011 14.8 0.1 1.4 1 0 0 1 1 1 1 Seadornavirus VP7 TMEM154 PF15102.6 EFC39450.1 - 0.068 13.1 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family Kinase-like PF14531.6 EFC39450.1 - 0.099 11.9 0.0 0.16 11.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFC39450.1 - 0.17 11.7 0.1 0.35 10.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SLIDE PF09111.10 EFC39450.1 - 0.19 11.7 0.5 0.47 10.5 0.5 1.6 1 0 0 1 1 1 0 SLIDE EGF_Tenascin PF18720.1 EFC39450.1 - 1 9.5 33.6 0.92 9.6 1.3 4.0 3 0 0 3 3 3 0 Tenascin EGF domain Cation_efflux PF01545.21 EFC39451.1 - 7.8e-20 71.5 12.0 3.5e-19 69.3 12.0 1.8 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFC39451.1 - 2e-12 47.0 0.1 5.9e-12 45.5 0.1 1.7 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter GP67 PF17634.2 EFC39451.1 - 0.072 13.5 1.1 7.8 7.0 0.8 2.6 2 0 0 2 2 2 0 Gene product 67 Orf78 PF06024.12 EFC39451.1 - 1.2 9.5 7.9 9.5 6.6 0.3 2.9 2 0 0 2 2 2 0 Orf78 (ac78) UDPGT PF00201.18 EFC39452.1 - 1.1e-13 50.9 0.1 1.8e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFC39452.1 - 8e-05 22.7 0.0 0.0002 21.4 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain Phage_T4_gp19 PF06841.12 EFC39452.1 - 0.054 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 T4-like virus tail tube protein gp19 Pkinase PF00069.25 EFC39453.1 - 3.1e-48 164.5 0.0 6.9e-48 163.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39453.1 - 4.3e-45 154.0 0.2 3.2e-43 147.9 0.2 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC39453.1 - 6.4e-19 67.0 0.0 0.0015 18.5 0.0 7.9 7 0 0 7 7 7 5 NHL repeat EGF_2 PF07974.13 EFC39453.1 - 8.9e-09 35.6 60.3 0.00068 20.0 11.3 4.9 4 0 0 4 4 4 3 EGF-like domain SGL PF08450.12 EFC39453.1 - 0.0018 17.9 0.4 0.069 12.7 0.0 3.7 4 1 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region APH PF01636.23 EFC39453.1 - 0.0044 17.0 0.0 0.0087 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC39453.1 - 0.01 14.8 2.0 0.028 13.4 0.1 2.5 2 1 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC39453.1 - 0.022 13.6 0.0 0.033 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SIT PF15330.6 EFC39453.1 - 0.047 14.1 0.1 0.13 12.7 0.1 1.8 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Arylesterase PF01731.20 EFC39453.1 - 0.074 13.3 0.4 7.2 6.9 0.0 3.9 3 1 1 4 4 4 0 Arylesterase GSDH PF07995.11 EFC39453.1 - 0.094 12.0 0.0 0.27 10.5 0.0 1.8 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase PALP PF00291.25 EFC39454.1 - 4.5e-63 213.4 2.3 1.4e-50 172.4 0.5 2.1 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 EFC39454.1 - 1.1e-06 28.3 0.0 2.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 EFC39454.1 - 0.0079 16.8 0.0 0.02 15.5 0.0 1.6 1 0 0 1 1 1 1 ACT domain SH3_12 PF18129.1 EFC39454.1 - 0.076 13.1 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 Xrn1 SH3-like domain TLD PF07534.16 EFC39455.1 - 1.9e-20 73.5 0.2 1.9e-20 73.5 0.2 2.0 2 0 0 2 2 2 1 TLD BTB PF00651.31 EFC39455.1 - 2.5e-17 63.1 2.3 4.5e-14 52.6 1.3 4.0 1 1 1 2 2 2 2 BTB/POZ domain BACK PF07707.15 EFC39455.1 - 6.4e-10 39.1 5.2 2.6e-07 30.7 0.3 3.3 3 0 0 3 3 3 2 BTB And C-terminal Kelch FMO-like PF00743.19 EFC39456.1 - 1e-101 341.0 0.3 1.2e-101 340.8 0.3 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 EFC39456.1 - 8.3e-16 58.1 0.4 2.5e-12 46.7 0.0 2.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC39456.1 - 2.8e-12 46.4 0.0 2.1e-10 40.3 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 EFC39456.1 - 7.1e-10 38.6 0.0 1.8e-07 30.7 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Prenylcys_lyase PF07156.14 EFC39456.1 - 0.033 13.3 0.1 0.066 12.3 0.1 1.5 1 0 0 1 1 1 0 Prenylcysteine lyase Shikimate_DH PF01488.20 EFC39456.1 - 0.16 12.0 0.2 0.8 9.8 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Big_9 PF17963.1 EFC39457.1 - 4.8e-126 411.8 194.7 1.6e-11 44.8 0.3 27.1 26 1 1 27 27 27 24 Bacterial Ig domain Cadherin_5 PF17892.1 EFC39457.1 - 1.2e-57 192.0 120.2 1.7e-06 27.9 0.9 23.3 19 3 5 24 24 24 16 Cadherin-like domain Cadherin_4 PF17803.1 EFC39457.1 - 2.2e-56 188.4 132.4 8.9e-09 35.9 0.2 21.6 20 1 1 21 21 21 14 Bacterial cadherin-like domain EGF_2 PF07974.13 EFC39457.1 - 9.6e-46 153.8 453.5 0.00019 21.7 15.3 22.3 20 1 2 22 22 22 20 EGF-like domain VWA PF00092.28 EFC39457.1 - 5.5e-23 82.1 0.2 1.9e-22 80.4 0.2 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC39457.1 - 1.1e-11 45.3 0.3 3.6e-11 43.7 0.3 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2712 PF10916.8 EFC39457.1 - 0.22 12.2 1.5 2.3 9.0 0.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2712) DUF2808 PF10989.8 EFC39457.1 - 4.6 7.2 7.5 1.6 8.7 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2808) LRR_6 PF13516.6 EFC39458.1 - 2e-16 58.5 61.1 0.0022 17.9 0.9 15.3 18 0 0 18 18 18 9 Leucine Rich repeat LRR_4 PF12799.7 EFC39458.1 - 4.5e-11 42.8 71.2 6.9e-06 26.3 2.0 11.3 6 3 6 13 13 13 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39458.1 - 0.00011 21.9 55.9 0.0029 17.3 3.4 9.5 6 4 4 10 10 10 7 Leucine rich repeat LRR_2 PF07723.13 EFC39458.1 - 0.067 13.9 7.1 2 9.2 0.2 6.6 6 0 0 6 6 6 0 Leucine Rich Repeat F-box-like PF12937.7 EFC39458.1 - 0.078 12.9 0.5 0.23 11.4 0.1 2.0 2 0 0 2 2 2 0 F-box-like PTH2 PF01981.16 EFC39459.1 - 6.6e-07 29.6 1.4 7.6e-07 29.4 0.2 1.7 2 0 0 2 2 2 1 Peptidyl-tRNA hydrolase PTH2 Astro_capsid_p PF12226.8 EFC39459.1 - 0.0022 17.2 14.1 0.0026 17.0 14.1 1.0 1 0 0 1 1 1 1 Turkey astrovirus capsid protein Zip PF02535.22 EFC39459.1 - 0.0024 17.2 0.2 0.0026 17.1 0.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Med13_C PF06333.12 EFC39459.1 - 0.051 12.8 0.6 0.055 12.7 0.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Pes-10 PF07149.11 EFC39459.1 - 0.11 11.6 8.5 0.12 11.5 8.5 1.1 1 0 0 1 1 1 0 Pes-10 Cwf_Cwc_15 PF04889.12 EFC39459.1 - 0.17 11.6 11.1 0.2 11.3 11.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.8 EFC39459.1 - 0.27 11.5 14.2 0.33 11.2 14.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 EFC39459.1 - 0.29 11.2 6.6 0.38 10.8 6.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Dicty_REP PF05086.12 EFC39459.1 - 0.35 8.8 5.5 0.46 8.4 5.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DNA_pol_phi PF04931.13 EFC39459.1 - 0.58 8.2 13.2 0.64 8.0 13.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFC39459.1 - 0.66 9.3 15.3 0.38 10.0 10.8 2.0 2 0 0 2 2 2 0 NOA36 protein DUF4820 PF16091.5 EFC39459.1 - 0.7 9.2 3.4 0.87 8.9 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF3439 PF11921.8 EFC39459.1 - 2.7 8.0 7.5 4 7.4 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Nop14 PF04147.12 EFC39459.1 - 2.9 6.0 11.6 3.2 5.9 11.6 1.0 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 EFC39459.1 - 3 7.0 6.4 3.5 6.8 6.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.9 EFC39459.1 - 3.4 6.7 15.7 4 6.5 15.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 EFC39459.1 - 3.6 5.8 8.9 4.2 5.5 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein GST_C_3 PF14497.6 EFC39460.1 - 4.6e-19 68.4 0.1 7.6e-19 67.7 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC39460.1 - 3.1e-10 40.1 0.0 5.2e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC39460.1 - 7.2e-06 26.3 0.0 1.7e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC39460.1 - 2.8e-05 24.0 0.0 5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC39460.1 - 0.0043 17.4 0.0 0.0098 16.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFC39460.1 - 0.087 12.6 0.1 8 6.3 0.0 2.4 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC39460.1 - 0.14 12.5 0.0 0.46 10.8 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain TPR_1 PF00515.28 EFC39461.1 - 3.4e-16 58.3 5.2 4.7e-08 32.5 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39461.1 - 3.9e-15 54.7 10.0 1.8e-06 27.6 0.0 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC39461.1 - 2e-10 40.0 8.2 0.00044 20.2 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC39461.1 - 1e-08 35.4 6.3 5.1e-05 23.5 0.4 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC39461.1 - 2e-06 28.1 0.2 0.2 12.4 0.0 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC39461.1 - 0.0014 19.2 0.0 1.6 9.5 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC39461.1 - 0.0023 18.0 0.0 0.021 15.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC39461.1 - 0.0024 17.8 1.4 2.9 8.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC39461.1 - 0.036 14.3 3.2 2 8.7 0.5 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC39461.1 - 0.055 13.9 3.1 2 9.0 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat F-box PF00646.33 EFC39461.1 - 0.11 12.4 2.8 0.1 12.5 0.5 2.2 3 0 0 3 3 3 0 F-box domain SHOCT PF09851.9 EFC39462.1 - 5.4e-08 32.3 3.0 1.1e-07 31.3 3.0 1.6 1 0 0 1 1 1 1 Short C-terminal domain RCC1 PF00415.18 EFC39463.1 - 3.6e-11 43.5 0.0 0.0013 19.3 0.0 5.0 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39463.1 - 4.5e-10 39.1 13.4 5.8e-05 22.8 0.9 5.1 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat HA2 PF04408.23 EFC39464.1 - 1.9e-12 47.4 0.0 1.9e-12 47.4 0.0 2.0 2 0 0 2 2 1 1 Helicase associated domain (HA2) IBR PF01485.21 EFC39464.1 - 4.9e-12 45.9 27.4 1.8e-07 31.2 6.9 4.6 4 0 0 4 4 2 2 IBR domain, a half RING-finger domain Kelch_6 PF13964.6 EFC39464.1 - 4e-11 42.8 1.7 8e-05 22.8 0.1 3.1 2 1 1 3 3 2 2 Kelch motif OB_NTP_bind PF07717.16 EFC39464.1 - 7.5e-10 39.0 0.1 3.1e-09 37.1 0.0 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Kelch_3 PF13415.6 EFC39464.1 - 1.3e-06 28.5 0.1 0.041 14.2 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC39464.1 - 2.9e-06 27.2 0.2 0.00041 20.3 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC39464.1 - 3.8e-06 26.4 4.4 0.043 13.4 0.1 3.7 4 0 0 4 4 4 2 Kelch motif KH_1 PF00013.29 EFC39464.1 - 5.4e-05 22.9 0.6 0.0034 17.2 0.5 3.2 2 0 0 2 2 2 1 KH domain zf-RING_UBOX PF13445.6 EFC39464.1 - 0.00041 20.3 13.6 0.00041 20.3 13.6 3.9 3 0 0 3 3 2 1 RING-type zinc-finger Kelch_2 PF07646.15 EFC39464.1 - 0.0073 16.3 0.2 2.3 8.3 0.1 3.0 2 0 0 2 2 2 1 Kelch motif SLS PF14611.6 EFC39464.1 - 0.0074 16.1 8.9 0.071 12.9 0.4 3.9 4 1 0 4 4 4 2 Mitochondrial inner-membrane-bound regulator zf-C3HC4_3 PF13920.6 EFC39464.1 - 0.0083 16.0 11.6 0.0083 16.0 11.6 4.8 3 1 1 4 4 2 1 Zinc finger, C3HC4 type (RING finger) Kelch_5 PF13854.6 EFC39464.1 - 0.087 12.8 0.0 7.2 6.7 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Actin PF00022.19 EFC39465.1 - 6.2e-123 410.4 0.0 3.5e-122 407.9 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC39465.1 - 0.0037 16.1 0.0 0.048 12.5 0.0 2.2 2 0 0 2 2 2 1 MreB/Mbl protein CENP-T_C PF15511.6 EFC39466.1 - 2.7e-10 40.3 0.1 3.3e-10 40.0 0.1 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFC39466.1 - 2.3e-05 24.8 0.1 2.6e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EFC39466.1 - 7.3e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFC39466.1 - 0.00012 22.3 0.0 0.00017 21.8 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFC39466.1 - 0.00014 22.1 0.2 0.00017 21.9 0.2 1.3 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EFC39466.1 - 0.00054 20.0 0.0 0.00066 19.7 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFC39466.1 - 0.007 16.3 0.1 0.0099 15.9 0.1 1.2 1 0 0 1 1 1 1 Bromodomain associated Ribosomal_S17e PF00833.18 EFC39466.1 - 0.029 14.3 0.2 0.035 14.0 0.2 1.2 1 0 0 1 1 1 0 Ribosomal S17 SIR2 PF02146.17 EFC39467.1 - 2e-52 177.6 0.6 2.4e-51 174.2 0.0 2.2 2 0 0 2 2 2 1 Sir2 family zf-UBP PF02148.19 EFC39467.1 - 7.8e-17 61.4 17.8 7.8e-17 61.4 17.8 2.0 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Milton PF12448.8 EFC39467.1 - 0.22 11.6 0.0 0.49 10.5 0.0 1.6 2 0 0 2 2 2 0 Kinesin associated protein DDE_3 PF13358.6 EFC39468.1 - 0.059 13.1 0.4 0.15 11.8 0.3 1.7 1 1 0 1 1 1 0 DDE superfamily endonuclease GTP_EFTU PF00009.27 EFC39469.1 - 1.6e-58 197.5 0.1 5.1e-58 195.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFC39469.1 - 3.3e-21 75.1 0.0 9.2e-21 73.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFC39469.1 - 6e-20 71.2 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EFC39469.1 - 4.1e-13 49.2 0.0 8.9e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFC39469.1 - 1.1e-10 41.8 0.0 3e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFC39469.1 - 0.0005 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFC39469.1 - 0.0075 16.3 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MycE_N PF17843.1 EFC39469.1 - 0.13 12.8 0.1 30 5.1 0.0 2.5 2 0 0 2 2 2 0 MycE methyltransferase N-terminal Abhydrolase_1 PF00561.20 EFC39470.1 - 0.00051 19.8 0.0 0.00086 19.0 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Popeye PF04831.13 EFC39470.1 - 0.0079 16.4 3.8 0.0079 16.4 3.8 2.1 2 0 0 2 2 2 1 Popeye protein conserved region Hydrolase_4 PF12146.8 EFC39470.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ndr PF03096.14 EFC39470.1 - 0.033 12.9 0.0 0.06 12.0 0.0 1.3 1 0 0 1 1 1 0 Ndr family Sperm_Ag_HE2 PF05324.13 EFC39470.1 - 0.077 13.5 0.0 0.35 11.3 0.0 2.1 2 0 0 2 2 2 0 Sperm antigen HE2 OAD_gamma PF04277.13 EFC39470.1 - 1.1 9.8 4.0 14 6.3 0.9 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Glucan_synthase PF02364.15 EFC39472.1 - 1.2e-32 113.1 10.5 1.1e-31 109.9 10.5 2.3 1 1 0 1 1 1 1 1,3-beta-glucan synthase component 2OG-FeII_Oxy_3 PF13640.6 EFC39473.1 - 1.2e-15 58.1 0.0 3.1e-15 56.9 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 EFC39473.1 - 1.2e-09 38.6 0.0 3.2e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EFC39473.1 - 0.018 15.4 0.0 0.049 14.0 0.0 1.7 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase PhyH PF05721.13 EFC39473.1 - 0.025 14.8 1.2 0.069 13.4 0.0 2.3 2 1 0 2 2 2 0 Phytanoyl-CoA dioxygenase (PhyH) YL1 PF05764.13 EFC39473.1 - 6 6.9 16.6 12 5.9 16.6 1.5 1 0 0 1 1 1 0 YL1 nuclear protein DUF4717 PF15838.5 EFC39473.1 - 7.9 6.6 9.0 1.3 9.1 4.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4717) Radical_SAM PF04055.21 EFC39474.1 - 6.2e-13 49.5 0.0 1.7e-12 48.0 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily HemN_C PF06969.16 EFC39474.1 - 1.5e-06 28.1 0.1 5.4e-06 26.4 0.1 2.0 2 0 0 2 2 2 1 HemN C-terminal domain MarR PF01047.22 EFC39474.1 - 0.012 15.6 0.2 0.063 13.2 0.0 2.2 2 0 0 2 2 2 0 MarR family HTH_27 PF13463.6 EFC39474.1 - 0.11 13.0 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain RGS PF00615.19 EFC39475.1 - 0.023 15.0 3.8 0.068 13.5 3.8 1.8 1 0 0 1 1 1 0 Regulator of G protein signaling domain Arylesterase PF01731.20 EFC39475.1 - 0.037 14.2 0.2 0.2 11.9 0.2 2.3 1 0 0 1 1 1 0 Arylesterase zf-AN1 PF01428.16 EFC39475.1 - 1.6 9.0 3.8 4.1 7.7 0.5 2.5 2 0 0 2 2 2 0 AN1-like Zinc finger Rxt3 PF08642.10 EFC39478.1 - 4.1e-11 43.8 0.1 2.1e-06 28.5 0.0 2.5 1 1 1 2 2 2 2 Histone deacetylation protein Rxt3 LCCL PF03815.19 EFC39478.1 - 3.5e-08 33.4 0.0 7.2e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 LCCL domain SEP PF08059.13 EFC39479.1 - 9.1e-25 87.0 0.7 1.5e-23 83.2 0.0 2.5 2 0 0 2 2 2 1 SEP domain UBX PF00789.20 EFC39479.1 - 5.8e-14 52.0 0.0 1.1e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 EFC39479.1 - 5e-12 45.4 0.7 1e-11 44.4 0.2 1.9 2 0 0 2 2 2 1 UBA-like domain TAP_C PF03943.13 EFC39479.1 - 0.04 13.6 0.0 0.083 12.5 0.0 1.6 1 0 0 1 1 1 0 TAP C-terminal domain Spore_GerAC PF05504.11 EFC39479.1 - 0.12 12.6 0.6 0.38 11.0 0.0 2.0 2 0 0 2 2 2 0 Spore germination B3/ GerAC like, C-terminal Inp1 PF12634.7 EFC39479.1 - 2.5 8.1 4.9 23 5.0 0.0 3.0 3 0 0 3 3 3 0 Inheritance of peroxisomes protein 1 DUF966 PF06136.13 EFC39479.1 - 4.3 7.0 14.3 0.81 9.3 4.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) NYN_YacP PF05991.11 EFC39480.1 - 2.3e-06 27.7 0.0 2.3e-06 27.7 0.0 2.7 3 0 0 3 3 3 1 YacP-like NYN domain PIN_9 PF18477.1 EFC39480.1 - 0.0022 18.3 1.1 0.037 14.3 0.0 2.9 3 0 0 3 3 3 1 PIN like domain SPT6_acidic PF14632.6 EFC39480.1 - 0.015 15.9 4.8 0.015 15.9 4.8 2.0 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Helicase_RecD PF05127.14 EFC39480.1 - 0.021 14.7 0.7 0.052 13.4 0.1 1.9 1 1 0 1 1 1 0 Helicase Toprim_Crpt PF13342.6 EFC39480.1 - 0.76 9.8 4.1 1 9.4 1.3 2.5 2 1 0 2 2 2 0 C-terminal repeat of topoisomerase Minor_capsid_1 PF10665.9 EFC39480.1 - 2.1 8.6 5.5 3.1 8.0 0.2 2.8 3 0 0 3 3 3 0 Minor capsid protein Kelch_1 PF01344.25 EFC39482.1 - 4.2e-11 42.3 0.3 0.011 15.3 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 EFC39482.1 - 2.5e-10 40.2 0.3 0.25 11.4 0.0 5.9 5 2 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC39482.1 - 4.9e-07 29.9 1.4 0.00037 20.7 0.0 4.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC39482.1 - 9.9e-07 28.5 0.6 0.88 9.7 0.0 4.8 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFC39482.1 - 3e-06 27.1 2.0 2.1 8.4 0.0 4.8 4 1 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EFC39482.1 - 0.00024 21.3 0.8 1 9.7 0.0 5.3 4 2 1 5 5 5 1 Kelch motif ADK PF00406.22 EFC39484.1 - 2.8e-11 43.7 0.1 1.1e-10 41.8 0.1 2.2 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFC39484.1 - 1.1e-07 32.3 0.0 3e-07 31.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFC39484.1 - 0.0093 16.5 0.0 0.024 15.2 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EFC39484.1 - 0.026 15.1 0.0 0.072 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain Retrotrans_gag PF03732.17 EFC39486.1 - 0.095 13.0 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Retrotransposon gag protein FAD_binding_4 PF01565.23 EFC39487.1 - 1.7e-26 92.6 0.0 2.8e-26 91.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFC39487.1 - 7.9e-07 29.1 1.2 1.6e-06 28.1 0.4 2.0 2 0 0 2 2 2 1 Berberine and berberine like LRR_6 PF13516.6 EFC39488.1 - 1.5e-38 127.5 31.3 0.00011 22.0 0.0 15.0 15 0 0 15 15 15 10 Leucine Rich repeat LRR_8 PF13855.6 EFC39488.1 - 3.7e-32 109.9 22.2 8.1e-07 28.7 0.7 7.4 3 2 6 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EFC39488.1 - 1.2e-25 89.2 37.8 0.0014 19.0 0.4 10.6 3 1 10 13 13 13 12 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39488.1 - 4.1e-08 32.7 21.4 3.6 8.5 0.3 12.7 14 2 1 15 15 15 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC39488.1 - 7.7e-07 28.8 13.8 0.031 13.8 0.5 5.1 1 1 3 5 5 5 3 Leucine-rich repeat DUF424 PF04242.13 EFC39488.1 - 1.8 8.9 7.2 2.6 8.4 0.1 4.1 4 2 1 5 5 5 0 Protein of unknown function (DUF424) DUF3430 PF11912.8 EFC39489.1 - 0.0017 18.4 21.1 0.0077 16.3 21.2 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3430) DUF4841 PF16129.5 EFC39489.1 - 0.084 13.1 1.1 11 6.3 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4841) C2 PF00168.30 EFC39490.1 - 2e-12 47.3 0.0 4.1e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 C2 domain Rho_GDI PF02115.17 EFC39492.1 - 1.9e-53 181.1 0.2 2.1e-53 181.0 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Ras PF00071.22 EFC39493.1 - 2.4e-47 160.6 0.0 2.7e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC39493.1 - 8.3e-18 64.7 0.0 1.3e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC39493.1 - 8.2e-11 41.7 0.0 9.8e-11 41.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Band_7 PF01145.25 EFC39495.1 - 5.8e-25 88.3 0.2 5.8e-25 88.3 0.2 1.9 1 1 1 2 2 2 1 SPFH domain / Band 7 family LBP_M PF17385.2 EFC39495.1 - 0.0097 15.4 0.8 0.017 14.7 0.8 1.3 1 0 0 1 1 1 1 Lacto-N-biose phosphorylase central domain Band_7_1 PF13421.6 EFC39495.1 - 0.011 15.4 0.2 0.011 15.4 0.2 1.7 2 0 0 2 2 2 0 SPFH domain-Band 7 family DUF724 PF05266.14 EFC39495.1 - 0.038 13.8 9.9 0.062 13.1 9.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF5449 PF17528.2 EFC39495.1 - 0.33 10.7 2.8 0.88 9.3 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5449) ICA69 PF04629.14 EFC39495.1 - 0.84 9.9 6.1 1.2 9.4 6.1 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain Big_9 PF17963.1 EFC39496.1 - 4.6e-112 367.0 254.2 7.4e-12 45.9 8.3 25.1 21 6 5 26 26 26 21 Bacterial Ig domain Cadherin_4 PF17803.1 EFC39496.1 - 6.6e-66 218.9 172.4 6.6e-09 36.3 7.5 21.1 20 1 0 21 21 21 17 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFC39496.1 - 1.8e-46 156.1 144.5 3.9e-09 36.4 2.1 21.9 17 3 6 23 23 23 15 Cadherin-like domain VWA PF00092.28 EFC39496.1 - 6.8e-20 72.0 1.3 2.2e-19 70.4 0.7 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC39496.1 - 1.1e-09 38.8 0.7 5e-09 36.8 0.7 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Cadherin_3 PF16184.5 EFC39496.1 - 0.0063 16.5 7.7 0.18 11.8 0.2 6.6 7 0 0 7 7 7 1 Cadherin-like Spo0M PF07070.11 EFC39496.1 - 0.13 11.8 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 SpoOM protein TLD PF07534.16 EFC39498.1 - 1.5e-19 70.6 0.6 2.6e-19 69.8 0.6 1.4 1 0 0 1 1 1 1 TLD Kelch_4 PF13418.6 EFC39498.1 - 0.0089 16.0 0.0 0.018 15.1 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain PseudoU_synth_1 PF01416.20 EFC39499.1 - 5.2e-09 36.5 0.0 3.2e-08 34.0 0.0 2.3 2 2 0 2 2 2 1 tRNA pseudouridine synthase SR-25 PF10500.9 EFC39499.1 - 0.0063 16.1 5.6 0.0092 15.6 5.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Repressor_Mnt PF11423.8 EFC39499.1 - 0.046 13.5 0.2 0.094 12.5 0.2 1.5 1 0 0 1 1 1 0 Regulatory protein Mnt Colicin-DNase PF12639.7 EFC39499.1 - 0.95 10.3 8.1 2.4 9.0 0.0 2.6 2 0 0 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin Presenilin PF01080.17 EFC39499.1 - 1.5 7.5 6.3 2 7.1 6.3 1.2 1 0 0 1 1 1 0 Presenilin Thioredoxin PF00085.20 EFC39500.1 - 5.5e-07 29.5 0.1 2.6e-05 24.1 0.1 3.1 2 0 0 2 2 2 1 Thioredoxin DUF2040 PF09745.9 EFC39501.1 - 3.7e-13 49.6 15.2 3.7e-13 49.6 15.2 3.7 3 1 0 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) F-box-like PF12937.7 EFC39502.1 - 6.1e-06 26.0 0.0 1.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC39502.1 - 7.6e-06 25.7 0.0 3.1e-05 23.7 0.0 2.1 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EFC39502.1 - 0.069 13.5 0.3 0.069 13.5 0.3 3.8 4 0 0 4 4 4 0 PRANC domain FRB_dom PF08771.11 EFC39502.1 - 0.34 11.3 3.6 2.4 8.6 0.2 3.2 3 1 0 3 3 3 0 FKBP12-rapamycin binding domain VWA PF00092.28 EFC39503.1 - 9.6e-21 74.8 0.7 3e-20 73.2 0.7 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Methyltransf_12 PF08242.12 EFC39503.1 - 9.8e-11 42.3 0.0 2.3e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain VWA_2 PF13519.6 EFC39503.1 - 6.8e-10 39.5 0.7 6.8e-10 39.5 0.7 1.9 2 0 0 2 2 1 1 von Willebrand factor type A domain Methyltransf_23 PF13489.6 EFC39503.1 - 7.9e-10 38.8 0.0 1.3e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC39503.1 - 1.1e-09 38.9 0.0 4.8e-09 36.8 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC39503.1 - 5e-08 33.5 0.0 2e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC39503.1 - 1.2e-05 25.2 0.0 2.6e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 EFC39503.1 - 0.00016 21.3 0.0 0.00037 20.1 0.0 1.6 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase MTS PF05175.14 EFC39503.1 - 0.014 14.9 0.2 0.12 12.0 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase small domain DREV PF05219.12 EFC39503.1 - 0.083 12.0 0.2 0.25 10.4 0.0 1.8 2 0 0 2 2 2 0 DREV methyltransferase ATP_synth_reg PF14960.6 EFC39503.1 - 0.086 12.3 0.2 15 5.2 0.1 2.5 2 0 0 2 2 2 0 ATP synthase regulation LRR_8 PF13855.6 EFC39504.1 - 0.00043 20.0 3.6 0.002 17.9 0.2 3.6 4 0 0 4 4 4 1 Leucine rich repeat LRR_4 PF12799.7 EFC39504.1 - 0.001 19.4 14.7 0.0039 17.6 0.7 6.1 4 3 1 5 5 5 1 Leucine Rich repeats (2 copies) ECH_1 PF00378.20 EFC39505.1 - 5.3e-37 127.5 0.0 8.5e-37 126.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC39505.1 - 4.5e-25 88.8 0.1 8.1e-25 88.0 0.1 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SPT16 PF08644.11 EFC39505.1 - 0.057 13.6 1.8 0.1 12.7 1.8 1.4 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) YliH PF10799.8 EFC39505.1 - 0.31 11.0 2.8 0.67 9.9 2.3 1.7 1 1 0 1 1 1 0 Biofilm formation protein (YliH/bssR) Thioredoxin_4 PF13462.6 EFC39507.1 - 2.6e-13 50.5 0.0 3.4e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 EFC39507.1 - 7.6e-06 25.8 0.0 0.0031 17.3 0.0 2.5 1 1 0 1 1 1 1 DSBA-like thioredoxin domain Pkinase PF00069.25 EFC39508.1 - 1.7e-52 178.4 0.7 2.7e-52 177.8 0.7 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39508.1 - 7.6e-30 104.0 0.2 1.2e-29 103.5 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC39508.1 - 2.7e-28 96.6 0.6 0.00079 19.3 0.0 9.3 8 0 0 8 8 8 5 NHL repeat SGL PF08450.12 EFC39508.1 - 3e-06 27.0 1.3 0.19 11.3 0.0 5.9 5 2 1 7 7 7 1 SMP-30/Gluconolactonase/LRE-like region Pkinase_fungal PF17667.1 EFC39508.1 - 7.3e-05 21.7 0.0 0.00014 20.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase SBBP PF06739.11 EFC39508.1 - 9.6e-05 22.3 1.3 0.065 13.2 0.0 4.6 3 0 0 3 3 3 1 Beta-propeller repeat TMEM154 PF15102.6 EFC39508.1 - 0.0014 18.5 0.4 0.0035 17.2 0.4 1.6 1 0 0 1 1 1 1 TMEM154 protein family 7TM_GPCR_Srw PF10324.9 EFC39508.1 - 0.0029 16.9 1.1 0.0062 15.8 1.1 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw DUF5385 PF17359.2 EFC39508.1 - 0.0055 16.3 3.5 0.011 15.2 3.5 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5385) RIFIN PF02009.16 EFC39508.1 - 0.0079 16.1 0.8 0.0079 16.1 0.8 1.8 2 0 0 2 2 2 1 Rifin RIO1 PF01163.22 EFC39508.1 - 0.012 15.2 1.8 0.027 14.1 0.7 2.0 2 0 0 2 2 2 0 RIO1 family Stevor PF17410.2 EFC39508.1 - 0.017 14.7 0.4 0.037 13.6 0.4 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame FixQ PF05545.11 EFC39508.1 - 0.018 15.0 0.2 0.039 13.9 0.2 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DPM3 PF08285.11 EFC39508.1 - 0.033 14.4 0.1 0.083 13.1 0.1 1.7 1 0 0 1 1 1 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) PspB PF06667.12 EFC39508.1 - 0.034 14.2 0.4 0.074 13.1 0.4 1.5 1 0 0 1 1 1 0 Phage shock protein B CD20 PF04103.15 EFC39508.1 - 0.045 13.8 0.1 0.11 12.6 0.1 1.6 1 0 0 1 1 1 0 CD20-like family YrbL-PhoP_reg PF10707.9 EFC39508.1 - 0.062 12.8 0.3 0.15 11.6 0.3 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Ly49 PF08391.10 EFC39508.1 - 0.073 13.4 0.4 0.28 11.6 0.4 1.9 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Orf78 PF06024.12 EFC39508.1 - 0.081 13.2 0.3 0.2 12.0 0.3 1.6 1 0 0 1 1 1 0 Orf78 (ac78) TMCCDC2 PF15844.5 EFC39508.1 - 0.18 11.7 2.9 0.61 10.0 0.7 2.4 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 EGF_Tenascin PF18720.1 EFC39508.1 - 0.26 11.4 4.8 0.98 9.5 4.8 2.1 1 0 0 1 1 1 0 Tenascin EGF domain ASFV_J13L PF05568.11 EFC39508.1 - 0.32 10.7 2.6 0.7 9.6 2.6 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein EGF_2 PF07974.13 EFC39508.1 - 0.37 11.2 12.6 0.97 9.9 12.6 1.8 1 0 0 1 1 1 0 EGF-like domain MRJP PF03022.16 EFC39508.1 - 0.95 8.8 6.7 1.3 8.4 0.2 3.8 2 1 2 4 4 4 0 Major royal jelly protein SKG6 PF08693.10 EFC39508.1 - 6.8 6.2 8.4 18 4.8 8.4 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Exonuc_VII_L PF02601.15 EFC39509.1 - 0.006 16.2 2.2 0.016 14.8 2.2 1.7 1 0 0 1 1 1 1 Exonuclease VII, large subunit FliD_C PF07195.12 EFC39509.1 - 0.017 14.5 0.8 0.017 14.5 0.8 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus zf-C2H2_4 PF13894.6 EFC39509.1 - 0.065 14.1 0.5 0.065 14.1 0.5 7.9 7 1 0 7 7 7 0 C2H2-type zinc finger PGAP1 PF07819.13 EFC39509.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein SlyX PF04102.12 EFC39509.1 - 0.38 11.4 2.5 0.67 10.6 0.9 2.3 2 0 0 2 2 2 0 SlyX ZapB PF06005.12 EFC39509.1 - 6.8 7.2 15.8 13 6.3 4.9 2.9 2 0 0 2 2 2 0 Cell division protein ZapB FWWh PF14922.6 EFC39510.1 - 0.071 13.0 0.3 0.071 13.0 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function Abhydrolase_6 PF12697.7 EFC39510.1 - 0.074 13.6 0.0 0.087 13.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Prefoldin PF02996.17 EFC39511.1 - 2.2e-12 46.9 0.9 2.2e-12 46.9 0.9 2.5 3 0 0 3 3 3 1 Prefoldin subunit Prefoldin_3 PF13758.6 EFC39511.1 - 0.00045 20.2 0.8 0.00045 20.2 0.8 3.0 2 1 0 2 2 2 1 Prefoldin subunit PMSI1 PF15322.6 EFC39511.1 - 0.29 10.5 8.4 0.11 11.9 3.3 2.2 2 1 0 2 2 2 0 Protein missing in infertile sperm 1, putative Glyco_hydro_44 PF12891.7 EFC39512.1 - 1.6e-68 231.2 1.5 1.6e-68 231.2 1.5 1.7 2 0 0 2 2 2 1 Glycoside hydrolase family 44 EGF_2 PF07974.13 EFC39512.1 - 8.5e-21 74.0 66.3 7.7e-05 23.0 7.5 5.4 5 0 0 5 5 5 5 EGF-like domain Pmp3 PF01679.17 EFC39513.1 - 2.1e-05 24.6 6.3 5.3e-05 23.3 6.3 1.6 1 1 0 1 1 1 1 Proteolipid membrane potential modulator DUF872 PF05915.12 EFC39513.1 - 0.041 14.0 0.0 0.055 13.6 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) Flavi_NS2B PF01002.19 EFC39513.1 - 0.26 11.1 1.4 0.45 10.4 0.2 1.8 1 1 0 2 2 2 0 Flavivirus non-structural protein NS2B FGAR-AT_N PF18076.1 EFC39514.1 - 0.066 13.2 0.1 0.094 12.7 0.1 1.3 1 0 0 1 1 1 0 Formylglycinamide ribonucleotide amidotransferase N-terminal Syntaxin PF00804.25 EFC39514.1 - 0.098 12.3 2.0 0.13 12.0 2.0 1.1 1 0 0 1 1 1 0 Syntaxin 4HBT PF03061.22 EFC39515.1 - 9.9e-13 48.3 0.0 3.1e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily DUF2306 PF10067.9 EFC39516.1 - 9.9e-21 74.5 11.7 1.6e-20 73.8 11.7 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2306) Guanylate_cyc PF00211.20 EFC39517.1 - 2.5e-29 102.2 0.0 5.6e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC39517.1 - 1.6e-05 24.8 3.9 8.8e-05 22.4 3.9 2.3 1 1 0 1 1 1 1 Cache domain TPR_2 PF07719.17 EFC39517.1 - 0.0011 18.9 0.1 0.0029 17.6 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC39517.1 - 0.033 14.0 0.1 0.11 12.4 0.1 1.9 1 1 0 1 1 1 0 Tetratricopeptide repeat TBK1_CCD1 PF18394.1 EFC39517.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 TPR_9 PF13371.6 EFC39517.1 - 0.7 10.1 2.5 0.38 10.9 0.3 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat RGS PF00615.19 EFC39518.1 - 2.2e-05 24.7 0.8 0.0002 21.6 0.1 2.7 2 1 0 2 2 2 1 Regulator of G protein signaling domain BACK PF07707.15 EFC39520.1 - 9.5e-19 67.4 0.6 3.2e-17 62.5 0.1 2.6 1 1 1 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 EFC39520.1 - 2.6e-11 43.7 1.5 1.4e-10 41.3 1.5 2.3 1 1 0 1 1 1 1 BTB/POZ domain SPRY PF00622.28 EFC39520.1 - 1.2e-06 28.6 0.3 2.8e-06 27.4 0.3 1.6 1 0 0 1 1 1 1 SPRY domain DUF4116 PF13475.6 EFC39521.1 - 1.3e-09 37.6 5.0 0.0091 15.7 0.3 4.4 2 1 0 3 3 3 3 Domain of unknown function (DUF4116) RNaseH_C PF09293.10 EFC39521.1 - 0.0079 16.5 0.3 0.24 11.8 0.0 2.8 3 0 0 3 3 3 1 T4 RNase H, C terminal Tenui_NCP PF04876.12 EFC39521.1 - 0.12 12.0 1.6 0.56 9.8 0.1 2.3 2 0 0 2 2 2 0 Tenuivirus major non-capsid protein Pkinase_Tyr PF07714.17 EFC39522.1 - 6.5e-52 176.4 0.5 4.5e-51 173.6 0.5 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC39522.1 - 1.8e-49 168.5 0.1 3.3e-49 167.6 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFC39522.1 - 0.0093 15.9 0.1 0.015 15.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC39522.1 - 0.1 11.4 0.2 0.16 10.7 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase Beta_helix PF13229.6 EFC39522.1 - 0.22 11.4 28.4 0.11 12.3 14.8 5.0 2 1 1 3 3 3 0 Right handed beta helix region Pentapeptide_3 PF13576.6 EFC39522.1 - 6.5 7.0 9.6 17 5.6 0.2 5.1 4 1 1 5 5 5 0 Pentapeptide repeats (9 copies) RGS PF00615.19 EFC39523.1 - 4.5e-07 30.1 1.2 9.7e-07 29.1 1.2 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Phage_NinH PF06322.11 EFC39523.1 - 0.0094 15.8 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 1 Phage NinH protein Deltameth_res PF16020.5 EFC39523.1 - 0.45 10.4 1.9 0.59 10.0 0.6 1.9 2 0 0 2 2 2 0 Deltamethrin resistance LRR_4 PF12799.7 EFC39524.1 - 1.1e-22 79.7 25.9 7.9e-08 32.5 4.0 6.7 3 2 5 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC39524.1 - 1.7e-21 74.3 28.1 0.0029 17.5 0.0 8.1 8 0 0 8 8 8 7 Leucine Rich repeat LRR_8 PF13855.6 EFC39524.1 - 2.2e-21 75.3 23.5 7.9e-07 28.7 0.1 5.9 6 2 1 8 8 8 3 Leucine rich repeat LRR_1 PF00560.33 EFC39524.1 - 9.7e-10 37.6 21.9 2.5 9.0 0.0 8.5 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_5 PF13306.6 EFC39524.1 - 2.7e-05 24.1 3.9 0.0029 17.6 0.4 2.3 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EFC39524.1 - 0.00077 19.0 8.1 0.4 10.2 3.3 3.5 1 1 2 3 3 3 3 Leucine-rich repeat MgtE_N PF03448.17 EFC39524.1 - 0.088 13.4 0.0 0.22 12.2 0.0 1.6 1 0 0 1 1 1 0 MgtE intracellular N domain MukF_C PF17193.4 EFC39524.1 - 0.098 12.8 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 MukF C-terminal domain Metallophos PF00149.28 EFC39525.1 - 1.8e-08 35.1 0.1 2.4e-08 34.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RhoGAP PF00620.27 EFC39526.1 - 6.2e-24 84.5 0.1 6.2e-24 84.5 0.1 2.8 3 1 0 3 3 3 1 RhoGAP domain F-box-like PF12937.7 EFC39527.1 - 0.0054 16.6 0.0 0.0083 16.0 0.0 1.2 1 0 0 1 1 1 1 F-box-like DUF5098 PF17023.5 EFC39527.1 - 0.038 13.0 14.2 0.05 12.6 3.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5098) Synapsin PF02078.16 EFC39527.1 - 0.057 13.7 0.9 0.09 13.1 0.9 1.3 1 0 0 1 1 1 0 Synapsin, N-terminal domain F-box PF00646.33 EFC39527.1 - 0.1 12.5 0.8 0.14 12.0 0.1 1.6 2 0 0 2 2 2 0 F-box domain FAM184 PF15665.5 EFC39527.1 - 0.11 12.3 16.6 0.65 9.7 16.7 1.8 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B SKA2 PF16740.5 EFC39527.1 - 0.23 11.2 12.2 0.1 12.4 7.9 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Seryl_tRNA_N PF02403.22 EFC39527.1 - 0.43 10.8 18.6 0.91 9.8 3.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PRANC PF09372.10 EFC39527.1 - 1.2 9.5 7.5 1.6 9.1 0.1 3.2 2 1 1 3 3 3 0 PRANC domain DUF1664 PF07889.12 EFC39527.1 - 2.2 8.3 13.0 2.8 8.0 3.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1053 PF06327.14 EFC39527.1 - 3.5 8.2 11.2 0.87 10.2 1.9 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1053) YlqD PF11068.8 EFC39527.1 - 4.6 7.6 21.0 2 8.8 9.6 2.1 1 1 0 2 2 2 0 YlqD protein Fib_alpha PF08702.10 EFC39527.1 - 8.4 6.6 13.7 6.4 7.0 11.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Guanylate_cyc PF00211.20 EFC39528.1 - 1.6e-21 76.7 0.7 1.6e-21 76.7 0.7 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain EI24 PF07264.11 EFC39529.1 - 0.037 14.3 0.3 0.057 13.7 0.3 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) HeH PF12949.7 EFC39530.1 - 0.00015 21.4 0.0 0.00063 19.4 0.0 2.1 1 0 0 1 1 1 1 HeH/LEM domain PTCRA PF15028.6 EFC39530.1 - 0.044 13.5 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Pre-T-cell antigen receptor SRP54 PF00448.22 EFC39531.1 - 5e-61 205.8 0.0 8.2e-61 205.1 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFC39531.1 - 2.5e-21 76.1 0.8 7.1e-21 74.7 0.1 2.1 2 0 0 2 2 1 1 Signal peptide binding domain SRP54_N PF02881.19 EFC39531.1 - 1.6e-12 47.5 4.1 1.6e-12 47.5 4.1 2.7 3 0 0 3 3 3 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 EFC39531.1 - 0.00041 20.5 0.0 0.00074 19.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EFC39531.1 - 0.00082 18.4 0.1 0.0026 16.8 0.0 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB 6PF2K PF01591.18 EFC39531.1 - 0.0038 16.6 0.0 0.0099 15.2 0.0 1.8 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Glyco_hydro_53 PF07745.13 EFC39531.1 - 0.004 16.2 0.1 0.0072 15.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 APS_kinase PF01583.20 EFC39531.1 - 0.011 15.7 0.1 0.036 13.9 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_16 PF13191.6 EFC39531.1 - 0.012 16.0 0.0 0.032 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EFC39531.1 - 0.015 14.9 1.0 0.34 10.5 1.0 2.4 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EFC39531.1 - 0.018 15.3 0.3 0.06 13.6 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EFC39531.1 - 0.051 13.6 0.2 0.15 12.1 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EFC39531.1 - 0.057 13.3 1.4 1.7 8.5 0.1 2.7 1 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFC39531.1 - 0.066 12.9 0.2 0.19 11.4 0.2 1.9 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFC39531.1 - 0.075 12.7 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EFC39531.1 - 0.082 13.3 2.3 0.11 12.9 0.4 2.2 2 1 0 2 2 1 0 AAA domain ATP_bind_1 PF03029.17 EFC39531.1 - 0.11 12.3 1.1 0.23 11.2 0.2 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Xpo1 PF08389.12 EFC39531.1 - 0.13 12.4 1.2 0.19 11.8 0.2 1.8 2 0 0 2 2 2 0 Exportin 1-like protein ArgoMid PF16487.5 EFC39531.1 - 0.13 12.6 0.2 0.44 10.8 0.2 1.9 1 0 0 1 1 1 0 Mid domain of argonaute AAA_25 PF13481.6 EFC39531.1 - 0.14 11.7 0.1 3.4 7.2 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFC39531.1 - 0.81 10.1 3.6 1.1 9.7 0.3 2.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) GPS PF01825.21 EFC39532.1 - 7.3e-08 32.8 6.4 7.3e-08 32.8 6.4 2.4 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC39532.1 - 4e-07 30.3 77.1 0.042 14.2 9.0 6.1 6 0 0 6 6 6 5 EGF-like domain RGS PF00615.19 EFC39532.1 - 6.1e-06 26.5 6.2 9.4e-06 25.9 0.2 3.7 2 1 0 3 3 3 1 Regulator of G protein signaling domain RSB_motif PF16294.5 EFC39532.1 - 0.54 10.6 9.8 1.1 9.5 9.8 1.4 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif Claudin_2 PF13903.6 EFC39532.1 - 7.7 6.2 13.3 0.056 13.2 0.6 3.1 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Syntaxin-18_N PF10496.9 EFC39533.1 - 0.014 15.6 0.2 0.091 13.0 0.0 2.1 1 1 1 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Pkinase PF00069.25 EFC39534.1 - 3.1e-57 193.9 5.7 3.9e-39 134.6 0.0 2.9 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39534.1 - 3.4e-44 151.1 3.2 4.3e-28 98.3 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase RCC1 PF00415.18 EFC39534.1 - 0.00044 20.8 0.0 0.11 13.2 0.0 3.4 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat CBFB_NFYA PF02045.15 EFC39535.1 - 7.2e-21 74.6 5.0 7.2e-21 74.6 5.0 2.3 2 0 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B zf-RING_2 PF13639.6 EFC39536.1 - 9e-19 67.5 32.6 4.5e-10 39.7 12.6 2.5 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 EFC39536.1 - 7.7e-15 54.6 33.8 9.5e-08 31.9 14.3 2.5 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFC39536.1 - 6.4e-13 48.5 25.0 5.8e-07 29.4 6.1 3.5 2 2 1 3 3 3 2 RING-type zinc-finger zf-RING_11 PF17123.5 EFC39536.1 - 5e-11 42.1 25.0 1.5e-05 24.7 10.0 2.8 2 0 0 2 2 2 2 RING-like zinc finger zf-ANAPC11 PF12861.7 EFC39536.1 - 1.3e-10 41.1 14.8 8.5e-07 28.9 3.7 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EFC39536.1 - 1e-09 38.1 27.5 5.6e-05 22.9 10.8 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFC39536.1 - 1.4e-09 38.1 27.3 6.1e-05 23.2 10.2 2.9 2 1 0 2 2 2 2 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFC39536.1 - 2.3e-09 36.9 31.1 7.7e-05 22.5 12.5 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC39536.1 - 1.2e-08 34.7 35.0 3.1e-05 23.7 14.3 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 EFC39536.1 - 0.00021 21.2 9.8 0.00021 21.2 9.8 3.9 2 2 1 3 3 3 1 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 EFC39536.1 - 0.0003 20.6 34.3 0.037 13.9 14.5 4.2 2 2 2 4 4 4 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EFC39536.1 - 0.00036 20.1 25.7 0.00084 18.9 8.0 2.8 2 1 1 3 3 3 2 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EFC39536.1 - 0.011 15.9 30.3 0.068 13.3 9.9 3.2 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING IQ PF00612.27 EFC39536.1 - 0.024 14.4 1.1 0.037 13.8 0.0 1.9 2 0 0 2 2 2 0 IQ calmodulin-binding motif zf-RING-like PF08746.11 EFC39536.1 - 0.04 14.2 11.2 0.04 14.2 11.2 3.2 2 1 1 3 3 3 0 RING-like domain DUF2779 PF11074.8 EFC39536.1 - 0.16 12.4 1.1 0.85 10.1 0.2 2.2 1 1 0 2 2 2 0 Domain of unknown function(DUF2779) Zf_RING PF16744.5 EFC39536.1 - 0.39 10.9 26.4 0.064 13.4 4.6 3.5 3 2 1 4 4 4 0 KIAA1045 RING finger PHD PF00628.29 EFC39536.1 - 4.4 7.3 27.4 0.43 10.5 9.4 2.9 2 1 0 2 2 2 0 PHD-finger FANCL_C PF11793.8 EFC39536.1 - 5.7 7.2 29.7 4.2 7.6 10.2 3.4 2 2 1 3 3 3 0 FANCL C-terminal domain TraD_N PF12615.8 EFC39537.1 - 0.063 14.0 0.2 0.2 12.5 0.2 1.8 1 0 0 1 1 1 0 F sex factor protein N terminal DUF4116 PF13475.6 EFC39538.1 - 0 1114.5 114.0 1.7e-15 56.4 0.0 36.7 22 6 14 40 40 40 40 Domain of unknown function (DUF4116) DUF1667 PF07892.11 EFC39538.1 - 2.3e-06 27.6 0.1 2.8 8.1 0.0 7.5 9 1 1 10 10 10 2 Protein of unknown function (DUF1667) DUF4853 PF16145.5 EFC39538.1 - 0.074 13.2 4.0 1.2e+02 2.8 0.0 6.2 5 1 1 6 6 6 0 Domain of unknown function (DUF4853) CholecysA-Rec_N PF09193.10 EFC39538.1 - 0.15 12.0 0.0 0.91 9.6 0.0 2.4 1 0 0 1 1 1 0 Cholecystokinin A receptor, N-terminal IL6 PF00489.17 EFC39538.1 - 0.48 10.0 16.8 0.52 9.9 0.1 6.4 6 0 0 6 6 6 0 Interleukin-6/G-CSF/MGF family NHL PF01436.21 EFC39539.1 - 9e-15 53.9 0.0 0.051 13.6 0.0 6.3 6 0 0 6 6 6 4 NHL repeat RGS PF00615.19 EFC39539.1 - 2.6e-09 37.4 1.6 8.6e-09 35.7 1.6 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain GPS PF01825.21 EFC39539.1 - 8.1e-09 35.9 4.5 2.1e-08 34.5 4.5 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif SGL PF08450.12 EFC39539.1 - 6.9e-06 25.8 0.0 0.00022 20.9 0.0 2.8 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 EFC39539.1 - 0.0046 16.3 0.0 0.016 14.5 0.0 1.8 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Arylesterase PF01731.20 EFC39539.1 - 0.012 15.8 0.0 0.2 11.9 0.0 3.2 3 0 0 3 3 3 0 Arylesterase EGF_2 PF07974.13 EFC39539.1 - 0.059 13.8 9.3 0.16 12.4 9.3 1.7 1 0 0 1 1 1 0 EGF-like domain DUF2321 PF10083.9 EFC39539.1 - 0.073 12.7 0.3 0.3 10.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) Str_synth PF03088.16 EFC39539.1 - 0.078 13.1 0.0 0.81 9.8 0.0 2.8 2 0 0 2 2 2 0 Strictosidine synthase PD40 PF07676.12 EFC39539.1 - 0.12 12.3 0.1 0.64 10.0 0.0 2.2 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Actin PF00022.19 EFC39540.1 - 3.3e-98 329.0 0.0 1.8e-97 326.5 0.0 1.8 1 1 0 1 1 1 1 Actin MAPEG PF01124.18 EFC39541.1 - 3.1e-13 49.8 0.4 4.8e-13 49.1 0.4 1.4 1 0 0 1 1 1 1 MAPEG family ABC_membrane_3 PF13748.6 EFC39541.1 - 0.022 14.0 0.1 0.029 13.6 0.1 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region DCAF17 PF15802.5 EFC39542.1 - 0.0048 15.6 0.0 0.0078 15.0 0.0 1.2 1 0 0 1 1 1 1 DDB1- and CUL4-associated factor 17 ANAPC4_WD40 PF12894.7 EFC39542.1 - 0.072 13.4 0.0 0.45 10.8 0.0 2.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain UvrD_C PF13361.6 EFC39543.1 - 1.6e-32 113.2 10.5 3e-19 69.6 0.0 2.9 2 1 1 3 3 3 2 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 EFC39543.1 - 4.2e-30 105.4 13.2 1.2e-20 74.2 5.9 3.4 3 2 1 4 4 4 2 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 EFC39543.1 - 6.6e-24 84.9 0.1 2.3e-23 83.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 EFC39543.1 - 9.4e-12 44.6 0.4 1.2e-10 41.0 0.4 2.3 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain PhoH PF02562.16 EFC39543.1 - 0.001 18.5 0.1 0.054 12.9 0.0 3.3 4 0 0 4 4 4 1 PhoH-like protein AAA_30 PF13604.6 EFC39543.1 - 0.0015 18.3 0.0 0.062 13.0 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EFC39543.1 - 0.0015 18.2 5.9 0.016 14.8 0.0 3.2 3 1 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 EFC39543.1 - 0.0049 16.6 0.2 22 4.7 0.0 4.0 3 2 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 EFC39543.1 - 0.006 16.4 3.0 0.0076 16.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF2373 PF10180.9 EFC39543.1 - 0.013 15.3 0.2 0.13 12.2 0.2 2.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) AAA_22 PF13401.6 EFC39543.1 - 0.031 14.5 1.1 2.5 8.4 0.1 2.9 1 1 1 2 2 2 0 AAA domain AAA_26 PF13500.6 EFC39543.1 - 0.043 13.6 0.6 1.4 8.7 0.4 2.6 2 0 0 2 2 2 0 AAA domain HTH_38 PF13936.6 EFC39543.1 - 0.052 13.3 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4200 PF13863.6 EFC39543.1 - 0.053 13.9 0.8 0.053 13.9 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Hydrolase_6 PF13344.6 EFC39543.1 - 0.089 12.9 0.2 6.3 7.0 0.0 3.5 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase PseudoU_synth_2 PF00849.22 EFC39543.1 - 0.09 12.9 3.5 0.043 13.9 0.6 1.9 2 0 0 2 2 2 0 RNA pseudouridylate synthase ResIII PF04851.15 EFC39543.1 - 0.28 11.1 7.7 0.028 14.4 1.5 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit HALZ PF02183.18 EFC39544.1 - 0.033 14.4 3.2 0.17 12.1 3.2 2.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper Pkinase PF00069.25 EFC39545.1 - 4.7e-41 140.9 0.1 4.7e-41 140.9 0.1 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39545.1 - 2.5e-32 112.2 0.0 5.6e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC39545.1 - 0.00079 18.8 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC39545.1 - 0.0012 18.3 0.0 0.0077 15.6 0.0 2.0 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC39545.1 - 0.042 12.6 0.1 0.042 12.6 0.1 2.7 3 0 0 3 3 3 0 Fungal protein kinase Mvb12 PF09452.10 EFC39545.1 - 0.22 12.0 3.3 2.2 8.7 2.0 2.7 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 DUF4834 PF16118.5 EFC39545.1 - 6.4 7.8 9.7 41 5.2 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) tRNA_anti-codon PF01336.25 EFC39546.1 - 0.011 15.7 0.1 0.02 14.9 0.1 1.4 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain CDP-OH_P_transf PF01066.21 EFC39547.1 - 1.2e-12 48.4 0.4 1.2e-12 48.4 0.4 2.6 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase CRISPR_Cas2 PF09827.9 EFC39549.1 - 0.11 12.7 0.2 0.22 11.7 0.2 1.5 1 0 0 1 1 1 0 CRISPR associated protein Cas2 RCC1 PF00415.18 EFC39550.1 - 1.3e-09 38.6 0.0 0.011 16.3 0.0 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39550.1 - 6.5e-05 22.6 3.1 3.4 7.6 0.1 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat ATPase_gene1 PF09527.10 EFC39551.1 - 0.011 15.9 0.7 0.011 15.9 0.7 2.4 2 1 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Imp-YgjV PF10688.9 EFC39551.1 - 0.014 15.2 3.5 0.014 15.2 3.5 1.6 1 1 0 1 1 1 0 Bacterial inner membrane protein DUF2534 PF10749.9 EFC39551.1 - 0.058 13.6 0.7 0.058 13.6 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2534) Metallophos PF00149.28 EFC39552.1 - 5.1e-14 53.3 1.4 7.3e-14 52.7 1.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase E3_UFM1_ligase PF09743.9 EFC39553.1 - 2.4e-70 237.2 12.8 2.4e-70 237.2 12.8 2.3 3 0 0 3 3 3 1 E3 UFM1-protein ligase 1 NHL PF01436.21 EFC39555.1 - 2.9e-09 36.5 0.1 0.00027 20.8 0.0 3.0 2 0 0 2 2 2 2 NHL repeat EGF_2 PF07974.13 EFC39555.1 - 6e-06 26.5 68.7 0.015 15.6 13.1 5.3 5 0 0 5 5 5 4 EGF-like domain Ras PF00071.22 EFC39555.1 - 5.6e-05 22.8 0.0 9.6e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Ras family EGF PF00008.27 EFC39555.1 - 5.7e-05 23.3 52.5 0.0013 19.0 10.5 5.0 4 0 0 4 4 4 3 EGF-like domain hEGF PF12661.7 EFC39555.1 - 0.023 15.3 26.2 0.031 14.9 9.1 5.9 7 0 0 7 7 7 0 Human growth factor-like EGF Arylesterase PF01731.20 EFC39555.1 - 0.14 12.3 0.1 0.68 10.2 0.0 2.1 1 1 1 2 2 2 0 Arylesterase DPCD PF14913.6 EFC39556.1 - 7.7e-67 224.4 2.7 9.5e-67 224.0 2.7 1.1 1 0 0 1 1 1 1 DPCD protein family Pih1_fungal_CS PF18482.1 EFC39556.1 - 0.91 10.1 5.7 2.2 8.9 0.7 2.7 2 1 1 3 3 3 0 Fungal Pih1 CS domain Lipocalin_4 PF13648.6 EFC39556.1 - 4.8 8.2 7.7 0.93 10.5 1.3 2.6 1 1 1 2 2 2 0 Lipocalin-like domain IFT46_B_C PF12317.8 EFC39557.1 - 3.1e-79 265.6 1.7 4.8e-79 265.0 1.7 1.2 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal RabGAP-TBC PF00566.18 EFC39558.1 - 2.4e-46 158.1 6.9 6.6e-46 156.7 6.9 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 EFC39558.1 - 1.1e-07 32.3 6.0 8.3e-05 23.1 0.9 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFC39558.1 - 2.1e-06 27.9 0.4 0.84 10.2 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFC39558.1 - 2.5e-06 27.7 0.4 0.00037 20.7 0.1 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC39558.1 - 3e-05 24.5 0.2 1.9 9.2 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC39558.1 - 0.00029 21.0 0.8 3 8.7 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat LRR_6 PF13516.6 EFC39559.1 - 5.7e-49 160.0 31.6 0.00026 20.8 0.1 15.0 16 0 0 16 16 16 11 Leucine Rich repeat LRR_8 PF13855.6 EFC39559.1 - 5.4e-28 96.5 30.8 3e-07 30.1 0.6 6.5 2 2 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC39559.1 - 1.1e-27 95.6 42.1 7.6e-05 23.0 0.2 9.0 6 3 2 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC39559.1 - 9.8e-08 31.7 8.6 0.044 13.3 0.4 4.2 1 1 1 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EFC39559.1 - 3.3e-07 29.9 23.8 14 6.8 0.0 11.4 11 2 0 11 11 11 1 Leucine Rich Repeat DUF4347 PF14252.6 EFC39559.1 - 6.2e-07 29.4 2.5 0.39 10.5 0.1 6.0 1 1 4 7 7 7 2 Domain of unknown function (DUF4347) Apo-VLDL-II PF05418.11 EFC39559.1 - 0.00035 21.1 0.3 7.1 7.3 0.0 4.6 4 1 1 5 5 5 1 Apovitellenin I (Apo-VLDL-II) RNA_pol_I_TF PF04090.12 EFC39559.1 - 0.94 8.9 12.0 11 5.5 0.1 4.8 1 1 2 5 5 5 0 RNA polymerase I specific initiation factor SF3A3 PF16837.5 EFC39559.1 - 1.3 9.6 11.4 2.2 8.8 0.2 4.6 3 1 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 DUF4869 PF16163.5 EFC39559.1 - 2.4 7.9 11.9 4 7.2 0.9 4.1 2 1 4 6 6 6 0 Domain of unknown function (DUF4869) zf-CCCH PF00642.24 EFC39560.1 - 4.7e-06 26.4 1.7 8.3e-06 25.6 1.7 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFC39560.1 - 0.0021 18.1 3.3 0.0033 17.4 3.3 1.3 1 0 0 1 1 1 1 Zinc finger domain PDEase_II PF02112.15 EFC39563.1 - 0.02 14.1 1.0 0.033 13.3 1.0 1.3 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II DUF1264 PF06884.11 EFC39564.1 - 1.3e-62 210.4 2.2 1.7e-62 210.0 2.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) zf-nanos PF05741.13 EFC39564.1 - 0.037 14.2 0.6 0.074 13.3 0.2 1.9 1 1 0 1 1 1 0 Nanos RNA binding domain HSP70 PF00012.20 EFC39565.1 - 1e-260 866.1 8.1 1.2e-260 865.9 8.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC39565.1 - 1.8e-18 66.5 5.0 3.9e-17 62.1 0.0 3.0 3 0 0 3 3 3 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC39565.1 - 0.0048 16.2 0.1 0.031 13.5 0.1 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase CPL PF08144.11 EFC39565.1 - 0.011 16.1 0.1 0.048 14.0 0.0 2.1 2 0 0 2 2 2 0 CPL (NUC119) domain EAP30 PF04157.16 EFC39565.1 - 0.023 14.0 2.0 0.24 10.6 0.5 2.4 2 0 0 2 2 2 0 EAP30/Vps36 family FtsA PF14450.6 EFC39565.1 - 0.03 14.7 0.6 12 6.4 0.0 3.4 3 1 0 3 3 3 0 Cell division protein FtsA DDR PF08841.10 EFC39565.1 - 0.033 13.2 1.5 0.47 9.4 0.1 2.7 3 0 0 3 3 3 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 EFC39565.1 - 0.069 12.6 0.0 4 6.8 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Cys_rich_FGFR PF00839.17 EFC39565.1 - 0.53 10.5 5.1 14 5.9 1.6 2.8 2 0 0 2 2 2 0 Cysteine rich repeat Erp_C PF06780.11 EFC39565.1 - 5.6 7.0 11.5 2.8 7.9 8.3 2.1 3 0 0 3 3 3 0 Erp protein C-terminus DDE_3 PF13358.6 EFC39566.1 - 4e-20 72.1 0.0 7.3e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease GHL13 PF14883.6 EFC39566.1 - 0.044 12.9 0.0 0.072 12.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 Hydrolase_6 PF13344.6 EFC39566.1 - 0.14 12.3 0.0 1.8 8.7 0.1 2.2 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase LRR_6 PF13516.6 EFC39567.1 - 1.3e-31 105.9 8.5 0.00066 19.5 0.0 8.8 9 0 0 9 9 9 7 Leucine Rich repeat LRR_8 PF13855.6 EFC39567.1 - 1.5e-23 82.3 8.3 2e-10 40.3 0.5 5.3 4 2 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC39567.1 - 1.8e-15 56.8 14.1 6.8e-05 23.2 0.2 6.6 2 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39567.1 - 1.3e-06 28.1 3.1 4.9 8.1 0.0 7.0 8 1 0 8 8 8 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC39567.1 - 1.2e-05 24.9 1.6 0.19 11.2 0.1 3.7 1 1 3 4 4 4 3 Leucine-rich repeat LRR_5 PF13306.6 EFC39567.1 - 0.00085 19.3 3.0 0.014 15.3 0.1 3.1 1 1 1 3 3 3 1 BspA type Leucine rich repeat region (6 copies) FTH PF01827.27 EFC39567.1 - 0.015 15.1 1.2 1.3 8.9 0.7 2.8 2 1 1 3 3 3 0 FTH domain F-box-like PF12937.7 EFC39567.1 - 0.094 12.6 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 F-box-like DUF3557 PF12078.8 EFC39568.1 - 2.1 8.3 10.1 3.9 7.4 7.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF3557) Ribosomal_S17_N PF16205.5 EFC39569.1 - 2.2e-32 111.2 3.2 1.1e-31 108.9 1.4 2.3 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 EFC39569.1 - 5.9e-26 90.4 2.4 8.8e-26 89.8 2.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 DUF4773 PF15998.5 EFC39570.1 - 0.0007 20.1 1.9 0.027 15.0 0.1 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4773) Fuseless PF15993.5 EFC39571.1 - 4e-12 45.9 12.5 3.7e-07 29.7 4.1 2.2 2 0 0 2 2 2 2 Fuseless DUF1700 PF08006.11 EFC39571.1 - 0.077 12.5 0.1 0.077 12.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) RNA_ligase PF09414.10 EFC39572.1 - 2.3e-07 31.2 0.0 5.9e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 RNA ligase Herpes_heli_pri PF05774.11 EFC39572.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component DUF5329 PF17263.2 EFC39573.1 - 0.081 13.1 0.1 1.9 8.7 0.0 3.0 4 0 0 4 4 4 0 Family of unknown function (DUF5329) Methyltransf_11 PF08241.12 EFC39575.1 - 4.1e-08 33.8 0.0 8.1e-07 29.6 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC39575.1 - 1.2e-07 31.7 0.1 2.3e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 EFC39575.1 - 7.1e-07 28.1 0.0 1.2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_25 PF13649.6 EFC39575.1 - 1.4e-05 25.7 0.0 6.8e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC39575.1 - 6.5e-05 22.8 0.3 0.00026 20.8 0.0 2.1 2 1 1 3 3 3 1 Methyltransferase domain DIOX_N PF14226.6 EFC39575.1 - 0.0019 19.0 0.1 0.028 15.2 0.0 2.7 3 0 0 3 3 3 1 non-haem dioxygenase in morphine synthesis N-terminal TFIID_NTD2 PF04494.15 EFC39575.1 - 0.0036 17.5 4.1 0.3 11.3 0.2 2.8 2 0 0 2 2 2 2 WD40 associated region in TFIID subunit, NTD2 domain Methyltransf_PK PF05891.12 EFC39575.1 - 0.0046 16.5 0.0 0.017 14.7 0.0 1.9 2 0 0 2 2 2 1 AdoMet dependent proline di-methyltransferase Methyltransf_12 PF08242.12 EFC39575.1 - 0.0077 16.9 0.0 0.033 14.9 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain PRELI PF04707.14 EFC39575.1 - 0.013 15.3 0.8 0.04 13.7 0.8 1.8 1 0 0 1 1 1 0 PRELI-like family Ubie_methyltran PF01209.18 EFC39575.1 - 0.024 14.0 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SAS-6_N PF16531.5 EFC39576.1 - 2.7e-23 82.3 0.3 4.7e-23 81.6 0.3 1.3 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal LRR_6 PF13516.6 EFC39578.1 - 5.6e-17 60.3 46.3 0.016 15.2 0.3 10.5 10 0 0 10 10 10 8 Leucine Rich repeat LRR_8 PF13855.6 EFC39578.1 - 1.5e-15 56.7 57.0 4.2e-07 29.6 11.6 5.3 1 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC39578.1 - 4.7e-13 49.1 62.0 0.00012 22.4 6.5 6.8 3 2 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC39578.1 - 0.00026 20.5 8.4 0.0023 17.5 5.8 2.7 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFC39578.1 - 0.013 16.0 47.7 1.1 10.1 1.0 10.3 9 1 0 9 9 9 0 Leucine Rich Repeat YjcQ PF09639.10 EFC39578.1 - 0.04 14.1 4.6 5.6 7.3 0.6 3.6 2 2 1 3 3 3 0 YjcQ protein PX PF00787.24 EFC39579.1 - 0.41 10.6 0.0 0.41 10.6 0.0 3.0 3 1 0 3 3 3 0 PX domain TFIIA PF03153.13 EFC39579.1 - 4.9 7.1 36.7 6.7 6.6 36.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Polyketide_cyc2 PF10604.9 EFC39580.1 - 8.2e-20 71.5 0.0 1e-19 71.2 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EFC39580.1 - 0.001 19.3 0.1 0.0013 19.0 0.1 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport LPAM_1 PF08139.12 EFC39581.1 - 0.0046 17.4 1.4 0.0066 16.9 1.4 1.2 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site Mfp-3 PF04202.13 EFC39581.1 - 0.03 14.7 5.3 0.03 14.7 5.3 3.3 1 1 1 2 2 2 0 Foot protein 3 C2 PF00168.30 EFC39583.1 - 3.1e-12 46.7 0.0 9.5e-12 45.1 0.0 1.9 1 0 0 1 1 1 1 C2 domain DiSB-ORF2_chro PF16506.5 EFC39583.1 - 0.043 13.8 0.9 6.2 6.9 0.2 2.6 2 0 0 2 2 2 0 Putative virion glycoprotein of insect viruses Desmo_N PF06771.11 EFC39584.1 - 0.051 13.9 0.1 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 Viral Desmoplakin N-terminus Cofilin_ADF PF00241.20 EFC39585.1 - 1.2e-29 102.6 0.0 1.5e-14 53.9 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Retinal PF15449.6 EFC39585.1 - 0.03 12.1 5.7 0.037 11.8 5.7 1.1 1 0 0 1 1 1 0 Retinal protein Herpes_pp85 PF04637.12 EFC39585.1 - 3.9 5.8 6.5 5.4 5.3 6.5 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF5391 PF17369.2 EFC39586.1 - 0.0041 17.2 0.9 0.0055 16.7 0.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5391) Response_reg PF00072.24 EFC39587.1 - 9.7e-18 64.4 1.4 3.8e-17 62.5 0.1 2.6 3 1 1 4 4 4 1 Response regulator receiver domain HATPase_c PF02518.26 EFC39587.1 - 6.1e-16 58.9 0.0 2e-15 57.2 0.0 2.0 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC39587.1 - 1.5e-07 31.4 1.3 1.2e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PhosphMutase PF10143.9 EFC39588.1 - 1.5e-49 168.1 0.0 2.6e-49 167.4 0.0 1.4 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 EFC39588.1 - 7.2e-31 107.4 0.0 8.9e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 EFC39588.1 - 0.00025 20.8 0.0 0.025 14.2 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFC39588.1 - 0.022 14.2 0.0 0.31 10.4 0.0 2.1 2 0 0 2 2 2 0 Sulfatase Pkinase PF00069.25 EFC39589.1 - 1.1e-28 100.3 1.4 2.3e-28 99.3 1.4 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39589.1 - 3.6e-19 69.1 0.1 7.4e-19 68.0 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4116 PF13475.6 EFC39589.1 - 1.9e-08 33.9 44.8 0.00022 20.9 1.7 8.7 7 2 1 8 8 8 5 Domain of unknown function (DUF4116) Kdo PF06293.14 EFC39589.1 - 0.045 13.1 0.0 0.082 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_4C PF11975.8 EFC39589.1 - 0.14 12.2 1.4 0.35 10.9 0.0 2.4 3 0 0 3 3 3 0 Family 4 glycosyl hydrolase C-terminal domain Actin PF00022.19 EFC39590.1 - 1.1e-120 403.0 0.0 4.7e-120 400.9 0.0 1.9 1 1 0 1 1 1 1 Actin Arf PF00025.21 EFC39591.1 - 2.4e-65 219.2 0.2 2.7e-65 219.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC39591.1 - 5e-14 52.2 0.0 5.5e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC39591.1 - 1.5e-13 50.6 1.6 5.1e-11 42.3 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC39591.1 - 8e-13 48.2 0.1 1e-12 47.9 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC39591.1 - 1.7e-12 47.6 0.2 2.5e-12 47.1 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC39591.1 - 3.1e-09 36.5 0.1 3.9e-09 36.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC39591.1 - 0.00057 19.9 0.0 0.00084 19.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1015 PF06245.11 EFC39591.1 - 0.068 12.0 0.1 0.083 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) Vmethyltransf PF01660.17 EFC39591.1 - 0.13 11.1 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase adh_short PF00106.25 EFC39592.1 - 7.5e-18 64.7 0.1 2.8e-09 36.7 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39592.1 - 1e-07 31.8 0.0 0.00014 21.5 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39592.1 - 0.0083 16.1 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 KR domain Arf PF00025.21 EFC39593.1 - 4.2e-68 228.2 0.2 7.6e-68 227.4 0.2 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC39593.1 - 1.8e-12 47.0 0.0 1.8e-12 47.0 0.0 1.6 2 0 0 2 2 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC39593.1 - 3e-12 46.4 0.5 8.9e-12 44.9 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC39593.1 - 2.3e-11 43.9 1.7 2.7e-11 43.7 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC39593.1 - 2.8e-09 36.6 7.1 9.8e-08 31.5 0.0 3.1 2 1 1 3 3 3 2 G-protein alpha subunit BTB PF00651.31 EFC39593.1 - 0.00015 22.0 0.1 0.00045 20.4 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain MMR_HSR1 PF01926.23 EFC39593.1 - 0.00031 20.8 2.0 0.00045 20.3 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF3391 PF11871.8 EFC39593.1 - 0.13 12.8 2.9 0.34 11.4 2.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) GTP_EFTU PF00009.27 EFC39593.1 - 0.28 10.7 0.0 0.28 10.7 0.0 2.1 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain DUF2971 PF11185.8 EFC39593.1 - 5.6 8.2 0.0 5.6 8.2 0.0 3.4 2 1 0 2 2 1 0 Protein of unknown function (DUF2971) DUF3464 PF11947.8 EFC39593.1 - 7.3 6.3 7.4 15 5.3 7.4 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 A_deaminase PF00962.22 EFC39594.1 - 1.2e-57 195.7 0.0 7e-39 134.1 0.0 3.1 2 1 1 3 3 3 3 Adenosine/AMP deaminase Methyltransf_25 PF13649.6 EFC39595.1 - 6.4e-05 23.6 0.0 0.00011 22.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 EFC39595.1 - 0.051 13.0 0.3 0.075 12.4 0.3 1.2 1 0 0 1 1 1 0 Spermine/spermidine synthase domain Cofilin_ADF PF00241.20 EFC39596.1 - 2.6e-23 82.1 0.7 2.9e-23 81.9 0.7 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SelP_C PF04593.14 EFC39596.1 - 0.0029 17.6 0.5 0.0037 17.3 0.5 1.2 1 0 0 1 1 1 1 Selenoprotein P, C terminal region HBS1_N PF08938.10 EFC39597.1 - 0.08 13.3 0.8 0.26 11.6 0.8 1.9 1 0 0 1 1 1 0 HBS1 N-terminus zf-RING_2 PF13639.6 EFC39601.1 - 3.6e-10 40.0 10.6 6e-10 39.3 10.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC39601.1 - 1.3e-07 31.3 9.8 2.2e-07 30.6 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC39601.1 - 1.1e-06 28.5 4.9 1.1e-06 28.5 4.9 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFC39601.1 - 3.3e-06 27.3 11.1 9.1e-06 25.9 11.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFC39601.1 - 4.8e-06 26.3 10.4 7.9e-06 25.6 10.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC39601.1 - 1.2e-05 25.0 6.8 1.8e-05 24.5 6.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC39601.1 - 1.9e-05 24.3 6.4 1.9e-05 24.3 6.4 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 EFC39601.1 - 0.00076 19.5 2.2 0.0016 18.4 2.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EFC39601.1 - 0.0073 16.2 9.6 0.012 15.5 9.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 EFC39601.1 - 0.038 13.6 5.4 0.066 12.9 5.4 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EFC39601.1 - 0.25 11.2 8.9 0.9 9.4 9.1 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 EFC39601.1 - 0.3 11.0 10.4 20 5.2 11.9 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Zf_RING PF16744.5 EFC39601.1 - 0.33 11.1 4.9 1.1 9.4 4.9 1.8 1 1 1 2 2 2 0 KIAA1045 RING finger FANCL_C PF11793.8 EFC39601.1 - 0.66 10.2 8.5 7.6 6.8 8.7 2.2 1 1 1 2 2 2 0 FANCL C-terminal domain PHD PF00628.29 EFC39601.1 - 0.86 9.5 8.0 1.7 8.6 8.0 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 EFC39601.1 - 0.92 9.7 10.3 1.9 8.7 10.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 EFC39601.1 - 0.95 9.8 7.4 2.5 8.5 7.4 1.8 1 1 0 1 1 1 0 RING-like domain RINGv PF12906.7 EFC39601.1 - 2 8.6 9.5 4 7.6 9.5 1.5 1 0 0 1 1 1 0 RING-variant domain Rad50_zn_hook PF04423.14 EFC39601.1 - 2.2 8.2 7.1 1.3 8.9 0.2 2.9 2 1 1 3 3 3 0 Rad50 zinc hook motif HhH-GPD PF00730.25 EFC39602.1 - 2.2e-19 69.9 0.1 7.4e-19 68.2 0.0 2.0 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 EFC39602.1 - 9.1e-11 41.7 0.1 2.7e-09 37.0 0.1 2.5 1 1 0 1 1 1 1 NUDIX domain HHH PF00633.23 EFC39602.1 - 2.2e-08 33.5 0.0 6.7e-08 32.0 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 EFC39602.1 - 0.00021 21.5 7.6 0.00038 20.7 7.6 1.4 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HHH_5 PF14520.6 EFC39602.1 - 0.048 14.3 0.0 0.86 10.3 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain PrgU PF09627.10 EFC39602.1 - 0.074 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 PrgU-like protein DUF3391 PF11871.8 EFC39602.1 - 3.8 8.1 12.4 6.2 7.4 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) LRR_6 PF13516.6 EFC39603.1 - 2.7e-36 120.5 16.4 0.00096 19.0 0.0 9.7 10 0 0 10 10 10 9 Leucine Rich repeat LRR_4 PF12799.7 EFC39603.1 - 8.5e-19 67.4 22.9 0.0025 18.2 0.3 6.6 3 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39603.1 - 7.9e-18 64.0 22.6 1.2e-06 28.2 0.4 5.7 4 2 2 6 6 6 5 Leucine rich repeat LRR_1 PF00560.33 EFC39603.1 - 7.8e-05 22.7 11.4 44 5.2 0.1 8.8 9 1 0 9 9 9 0 Leucine Rich Repeat YqbF PF14553.6 EFC39603.1 - 0.037 13.9 0.4 0.12 12.2 0.2 2.0 1 1 1 2 2 2 0 YqbF, hypothetical protein domain LRR_9 PF14580.6 EFC39603.1 - 0.038 13.5 5.2 6.8 6.2 0.1 3.7 1 1 4 5 5 5 0 Leucine-rich repeat FtsK_SpoIIIE PF01580.18 EFC39604.1 - 3.5 6.9 8.0 0.29 10.4 1.0 2.5 2 1 1 3 3 3 0 FtsK/SpoIIIE family DUF1664 PF07889.12 EFC39604.1 - 7.2 6.7 50.1 0.29 11.2 8.4 5.2 2 2 2 5 5 5 0 Protein of unknown function (DUF1664) Big_9 PF17963.1 EFC39606.1 - 6.7e-27 94.1 15.0 4.9e-13 49.6 1.1 3.5 3 0 0 3 3 3 3 Bacterial Ig domain Cadherin_5 PF17892.1 EFC39606.1 - 2e-13 50.1 7.7 9e-07 28.8 1.8 2.3 2 0 0 2 2 2 2 Cadherin-like domain Cadherin_4 PF17803.1 EFC39606.1 - 6.6e-13 49.1 12.1 4.4e-09 36.8 0.6 3.7 3 0 0 3 3 3 3 Bacterial cadherin-like domain Vps16_C PF04840.12 EFC39606.1 - 0.066 12.2 0.0 0.093 11.7 0.0 1.1 1 0 0 1 1 1 0 Vps16, C-terminal region Beta-lactamase PF00144.24 EFC39607.1 - 1.7e-65 221.4 0.0 1.1e-36 126.8 0.0 2.3 2 0 0 2 2 2 2 Beta-lactamase DUF4715 PF15835.5 EFC39607.1 - 0.044 13.8 0.0 0.099 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) Beta-lactamase2 PF13354.6 EFC39607.1 - 0.064 12.9 0.0 17 4.9 0.0 3.1 3 0 0 3 3 3 0 Beta-lactamase enzyme family FAM194 PF14977.6 EFC39607.1 - 0.071 12.4 0.1 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 FAM194 protein Arf PF00025.21 EFC39608.1 - 4.8e-37 127.1 0.1 8.7e-32 110.0 0.2 3.3 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 EFC39608.1 - 1.5e-08 34.9 0.0 4.2e-08 33.4 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC39608.1 - 1.7e-07 30.8 2.3 5.9e-07 29.0 0.2 2.5 1 1 1 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC39608.1 - 3.2e-05 23.4 0.3 0.00047 19.6 0.3 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 EFC39608.1 - 5.1e-05 22.9 0.0 9.8e-05 22.0 0.0 1.5 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFC39608.1 - 0.0014 18.1 0.1 0.022 14.2 0.1 2.3 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC39608.1 - 0.016 15.3 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Peptidase_M60 PF13402.6 EFC39610.1 - 7.8e-54 183.0 0.2 1.6e-53 182.0 0.2 1.5 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like DUF4493 PF14900.6 EFC39610.1 - 0.049 13.5 3.7 0.057 13.3 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4493) Big_9 PF17963.1 EFC39611.1 - 4e-77 255.1 131.1 2.9e-12 47.2 5.2 13.8 12 1 0 12 12 12 12 Bacterial Ig domain Cadherin_4 PF17803.1 EFC39611.1 - 1.4e-42 144.2 104.8 6.2e-10 39.6 4.2 12.9 11 2 0 11 11 11 10 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFC39611.1 - 4.6e-22 77.8 73.1 8.6e-06 25.6 1.9 13.6 10 3 3 13 13 13 10 Cadherin-like domain VWA PF00092.28 EFC39611.1 - 3.9e-13 50.0 0.0 1.2e-12 48.4 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC39611.1 - 3.7e-10 40.4 0.0 1e-09 39.0 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain p450 PF00067.22 EFC39612.1 - 6.6e-85 285.6 2.2 7.7e-85 285.4 2.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 RGS PF00615.19 EFC39613.1 - 2e-09 37.8 3.6 2.8e-09 37.3 0.5 2.3 1 1 1 2 2 2 1 Regulator of G protein signaling domain YukD PF08817.10 EFC39613.1 - 0.2 12.4 0.1 3.8 8.3 0.0 2.3 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD PPR_2 PF13041.6 EFC39615.1 - 1e-16 60.8 11.3 2.9e-06 27.4 0.5 6.5 5 1 2 7 7 7 4 PPR repeat family PPR_1 PF12854.7 EFC39615.1 - 1.5e-16 59.8 3.2 4e-07 29.6 0.0 4.7 4 0 0 4 4 4 3 PPR repeat PPR PF01535.20 EFC39615.1 - 6.6e-14 51.1 11.9 3.2e-05 23.9 0.2 6.1 7 0 0 7 7 7 3 PPR repeat PPR_long PF17177.4 EFC39615.1 - 7.4e-08 32.0 0.0 1.6e-06 27.7 0.0 2.5 2 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP RPN6_N PF18055.1 EFC39615.1 - 0.00047 20.5 1.6 0.00079 19.8 1.1 1.7 1 1 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain PPR_3 PF13812.6 EFC39615.1 - 0.0021 18.1 6.9 0.028 14.5 0.0 4.2 5 1 0 5 5 5 1 Pentatricopeptide repeat domain ATP13 PF12921.7 EFC39615.1 - 0.016 15.0 0.3 0.17 11.8 0.0 2.6 2 1 1 3 3 3 0 Mitochondrial ATPase expression Hydantoinase_B PF02538.14 EFC39615.1 - 0.052 12.0 0.0 0.076 11.4 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase EF-G-binding_N PF07299.11 EFC39615.1 - 0.064 13.8 0.4 0.25 11.9 0.4 2.1 1 0 0 1 1 1 0 Elongation factor G-binding protein, N-terminal DUF4427 PF14468.6 EFC39615.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4427) DNA_mis_repair PF01119.19 EFC39616.1 - 4.4e-14 52.2 0.1 1.2e-13 50.8 0.1 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 EFC39616.1 - 1.3e-13 51.0 0.3 1.3e-13 51.0 0.3 2.2 2 1 1 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFC39616.1 - 4.8e-06 27.1 0.4 1.1e-05 25.9 0.4 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PEARLI-4 PF05278.12 EFC39616.1 - 0.57 9.7 8.0 0.25 10.9 5.3 1.8 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Macoilin PF09726.9 EFC39616.1 - 1.2 7.6 22.5 1.7 7.1 22.5 1.3 1 0 0 1 1 1 0 Macoilin family NOA36 PF06524.12 EFC39616.1 - 2.1 7.6 12.5 1.6 8.0 10.9 1.5 2 0 0 2 2 2 0 NOA36 protein Ras PF00071.22 EFC39618.1 - 3.3e-29 101.6 0.0 1.3e-28 99.6 0.0 2.1 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFC39618.1 - 5.4e-09 36.3 0.4 5.8e-07 29.8 0.0 3.2 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC39618.1 - 0.0019 18.1 0.4 0.0019 18.1 0.4 2.3 3 0 0 3 3 3 1 F-box domain MIT_C PF16565.5 EFC39618.1 - 0.022 14.7 0.5 0.06 13.3 0.5 1.7 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT Arf PF00025.21 EFC39618.1 - 0.029 13.8 0.0 0.1 12.1 0.0 1.9 1 1 1 2 2 2 0 ADP-ribosylation factor family F-box-like PF12937.7 EFC39618.1 - 0.043 13.7 0.5 0.11 12.5 0.1 1.9 2 0 0 2 2 2 0 F-box-like DUF4597 PF15366.6 EFC39618.1 - 0.19 11.5 1.2 0.3 10.8 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) NDUFB11 PF17250.2 EFC39619.1 - 0.002 18.7 0.6 0.0027 18.3 0.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase 11 kDa subunit End_beta_barrel PF12195.8 EFC39619.1 - 0.05 13.5 0.2 0.075 13.0 0.2 1.2 1 0 0 1 1 1 0 Beta barrel domain of bacteriophage endosialidase PAF-AH_p_II PF03403.13 EFC39619.1 - 0.11 10.9 0.6 0.2 10.2 0.2 1.6 1 1 1 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II PCI PF01399.27 EFC39620.1 - 2.2 8.8 6.0 1.2 9.7 1.0 3.1 3 1 0 3 3 3 0 PCI domain Zn_clus PF00172.18 EFC39621.1 - 5.3e-07 29.7 10.5 1.8e-06 28.0 10.5 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CD225 PF04505.12 EFC39621.1 - 0.03 14.5 0.2 0.064 13.4 0.2 1.5 1 0 0 1 1 1 0 Interferon-induced transmembrane protein TPR_12 PF13424.6 EFC39621.1 - 0.14 12.5 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat PARP PF00644.20 EFC39622.1 - 1.1e-27 96.9 2.3 7.7e-27 94.1 2.3 2.2 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain NPP PF08384.10 EFC39623.1 - 0.05 13.7 0.3 0.098 12.7 0.3 1.4 1 0 0 1 1 1 0 Pro-opiomelanocortin, N-terminal region Arf PF00025.21 EFC39624.1 - 7.4e-55 185.1 0.1 1.5e-54 184.1 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC39624.1 - 5.9e-11 42.6 0.0 1.2e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC39624.1 - 5.2e-10 39.1 0.0 9.5e-10 38.3 0.0 1.5 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFC39624.1 - 5.4e-10 39.0 0.0 9.1e-10 38.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC39624.1 - 8.8e-10 38.3 9.3 4.4e-06 26.1 0.1 2.8 2 1 1 3 3 3 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC39624.1 - 4e-07 29.6 0.7 1.5e-06 27.7 0.0 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region BTB PF00651.31 EFC39624.1 - 8.8e-07 29.1 0.3 1.6e-06 28.3 0.3 1.5 1 0 0 1 1 1 1 BTB/POZ domain MMR_HSR1 PF01926.23 EFC39624.1 - 2.5e-06 27.5 0.0 5.7e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFC39624.1 - 0.057 13.5 0.1 1.4 9.0 0.0 2.4 1 1 1 2 2 2 0 Dynamin family F-box-like PF12937.7 EFC39625.1 - 0.0002 21.2 0.0 0.00043 20.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC39625.1 - 0.00027 20.7 0.1 0.00069 19.4 0.0 1.7 2 0 0 2 2 2 1 F-box domain F-box PF00646.33 EFC39626.1 - 9.4e-05 22.2 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC39626.1 - 0.0055 16.6 0.0 0.015 15.1 0.0 1.6 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 EFC39626.1 - 0.065 13.1 0.1 1.2 9.1 0.0 2.3 1 1 0 2 2 2 0 F-box Chromate_transp PF02417.15 EFC39627.1 - 5.2e-69 231.4 32.4 5.7e-37 127.3 13.0 2.3 2 0 0 2 2 2 2 Chromate transporter Flavi_NS4A PF01350.17 EFC39627.1 - 0.11 12.5 1.1 0.26 11.2 1.1 1.6 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A Phage_holin_5_2 PF16079.5 EFC39627.1 - 7.6 6.9 16.3 5.8 7.3 0.0 4.6 4 1 1 5 5 5 0 Phage holin family Hol44, in holin superfamily V adh_short PF00106.25 EFC39628.1 - 8.3e-18 64.5 0.1 3.2e-11 43.0 0.0 2.4 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39628.1 - 4.9e-13 49.2 0.0 2.4e-05 24.0 0.0 2.4 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase Pho88 PF10032.9 EFC39628.1 - 0.026 13.8 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 Phosphate transport (Pho88) ANAPC4 PF12896.7 EFC39628.1 - 0.054 13.0 1.1 0.087 12.3 0.3 1.9 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 KR PF08659.10 EFC39628.1 - 0.11 12.4 0.0 0.27 11.1 0.0 1.6 2 0 0 2 2 2 0 KR domain Sel1 PF08238.12 EFC39629.1 - 4.9e-69 227.2 18.3 4.2e-11 43.1 0.3 7.9 8 0 0 8 8 8 7 Sel1 repeat TPR_17 PF13431.6 EFC39629.1 - 5.5e-06 26.4 10.4 0.92 10.0 0.1 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC39629.1 - 0.001 19.6 1.4 5.1 8.0 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC39629.1 - 0.0075 16.5 11.7 0.059 13.7 0.0 5.8 6 2 1 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC39629.1 - 0.0091 15.8 0.2 0.0091 15.8 0.2 8.1 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39629.1 - 0.062 13.4 0.1 0.062 13.4 0.1 7.8 8 2 2 10 10 10 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC39629.1 - 0.23 11.4 13.8 14 5.7 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC39629.1 - 0.36 11.1 5.5 55 4.1 4.1 3.6 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFC39629.1 - 8.4 6.2 26.9 2.8 7.7 2.7 6.2 5 1 1 6 6 6 0 TPR repeat G-alpha PF00503.20 EFC39630.1 - 5.3e-57 193.6 28.5 5.3e-57 193.6 28.5 2.0 2 1 0 2 2 2 1 G-protein alpha subunit Pkinase PF00069.25 EFC39630.1 - 2.4e-44 151.7 0.2 9.9e-44 149.7 0.2 2.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39630.1 - 1.8e-26 93.0 0.2 2.6e-24 85.9 0.2 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Arf PF00025.21 EFC39630.1 - 1.7e-07 30.9 0.4 9.7e-07 28.4 0.4 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC39630.1 - 0.00035 20.6 0.8 0.21 11.7 0.2 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC39630.1 - 0.0013 18.1 3.4 0.0085 15.5 2.0 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EFC39630.1 - 0.0058 17.1 1.2 0.0058 17.1 1.2 2.8 2 1 0 2 2 2 1 ABC transporter GTP_EFTU PF00009.27 EFC39630.1 - 0.028 13.9 0.5 0.074 12.6 0.2 2.0 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EFC39630.1 - 0.073 12.8 0.0 0.24 11.2 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain APH PF01636.23 EFC39630.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RNA_helicase PF00910.22 EFC39630.1 - 3.5 8.1 6.3 7.1 7.1 0.5 3.4 3 1 0 3 3 3 0 RNA helicase RAG1_imp_bd PF12560.8 EFC39631.1 - 0.039 13.5 1.0 0.04 13.5 1.0 1.2 1 0 0 1 1 1 0 RAG1 importin binding Rad51 PF08423.11 EFC39632.1 - 1.7e-14 53.7 0.5 4.4e-14 52.4 0.5 1.6 1 1 0 1 1 1 1 Rad51 ATPase PF06745.13 EFC39632.1 - 8.4e-08 31.8 0.3 1.8e-07 30.8 0.3 1.5 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 EFC39632.1 - 9.8e-05 22.0 0.0 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 EFC39632.1 - 0.0082 15.6 0.0 1.5 8.3 0.0 2.4 2 1 0 2 2 2 2 recA bacterial DNA recombination protein CobU PF02283.16 EFC39632.1 - 0.19 11.3 0.2 2.5 7.6 0.2 2.2 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase LRR_4 PF12799.7 EFC39632.1 - 8.9 6.9 33.5 1.4 9.4 0.2 8.7 8 1 0 8 8 8 0 Leucine Rich repeats (2 copies) AMP-binding PF00501.28 EFC39633.1 - 6.5e-60 202.9 0.0 1.1e-59 202.1 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC39633.1 - 2.7e-05 25.0 0.2 5.8e-05 24.0 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_C42 PF05533.12 EFC39633.1 - 0.015 15.3 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 PhoPQ_related PF10142.9 EFC39634.1 - 7.7e-79 265.0 0.4 1.1e-78 264.5 0.4 1.2 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Trypsin PF00089.26 EFC39634.1 - 9.8e-35 120.4 5.7 2.2e-34 119.2 5.7 1.6 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC39634.1 - 0.0004 21.3 0.2 0.0011 19.8 0.2 1.8 1 0 0 1 1 1 1 Trypsin-like peptidase domain ANAPC4_WD40 PF12894.7 EFC39635.1 - 0.012 15.9 0.0 0.95 9.8 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain NHL PF01436.21 EFC39635.1 - 0.65 10.1 2.1 1.1 9.4 0.1 2.5 3 0 0 3 3 3 0 NHL repeat adh_short PF00106.25 EFC39636.1 - 7.9e-16 58.1 0.0 3.1e-14 52.9 0.2 2.3 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39636.1 - 1.2e-11 44.7 0.0 1.9e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39636.1 - 2.3e-06 27.7 0.1 4e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 KR domain PAE PF03283.13 EFC39636.1 - 0.003 16.8 0.1 0.004 16.3 0.1 1.2 1 0 0 1 1 1 1 Pectinacetylesterase NAD_binding_10 PF13460.6 EFC39636.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.6 1 1 0 1 1 1 0 NAD(P)H-binding DUF4379 PF14311.6 EFC39637.1 - 0.04 14.3 0.2 0.04 14.3 0.2 1.9 2 0 0 2 2 2 0 Probable Zinc-ribbon domain CHCH PF06747.13 EFC39637.1 - 0.062 13.5 2.0 0.062 13.5 2.0 2.3 2 0 0 2 2 2 0 CHCH domain NAD_binding_1 PF00175.21 EFC39638.1 - 5.7e-09 36.6 0.0 1.7e-08 35.1 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Putative_PNPOx PF01243.20 EFC39638.1 - 9.1e-09 35.4 0.0 2.4e-07 30.9 0.0 2.5 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase FAD_binding_6 PF00970.24 EFC39638.1 - 6.2e-06 26.5 0.1 0.00081 19.7 0.0 2.9 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFC39638.1 - 6.5e-05 23.1 0.1 0.0005 20.2 0.0 2.2 1 1 1 2 2 2 1 Ferric reductase NAD binding domain ThiF PF00899.21 EFC39639.1 - 1.4e-46 158.9 0.1 2.1e-46 158.3 0.1 1.2 1 0 0 1 1 1 1 ThiF family NAD_binding_7 PF13241.6 EFC39639.1 - 0.021 15.2 0.0 0.12 12.8 0.0 2.2 2 1 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_2 PF03446.15 EFC39639.1 - 0.044 13.9 0.1 0.11 12.7 0.1 1.7 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFC39639.1 - 0.17 11.2 0.6 0.45 9.9 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ASL_C PF08328.11 EFC39639.1 - 1.2 9.3 4.3 0.54 10.4 1.1 2.1 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminal Sacchrp_dh_NADP PF03435.18 EFC39639.1 - 1.5 9.0 5.2 24 5.2 2.2 2.9 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain bZIP_2 PF07716.15 EFC39639.1 - 5.4 7.2 8.3 16 5.7 8.3 1.8 1 0 0 1 1 1 0 Basic region leucine zipper UDPG_MGDP_dh_N PF03721.14 EFC39639.1 - 8.5 5.9 8.7 0.15 11.6 0.9 2.2 3 1 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GBP_C PF02841.14 EFC39639.1 - 9.2 5.6 16.1 2 7.8 5.2 2.9 3 0 0 3 3 3 0 Guanylate-binding protein, C-terminal domain RhoGAP PF00620.27 EFC39641.1 - 6.6e-35 120.2 0.0 1.5e-34 119.0 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain Pkinase PF00069.25 EFC39642.1 - 3.1e-34 118.5 2.4 3.1e-34 118.5 2.4 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39642.1 - 3e-17 62.8 0.1 5.5e-17 61.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SPRY PF00622.28 EFC39642.1 - 0.00041 20.4 0.0 0.0011 19.0 0.0 1.7 1 0 0 1 1 1 1 SPRY domain YrbL-PhoP_reg PF10707.9 EFC39642.1 - 0.076 12.5 0.1 0.22 11.0 0.1 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL EVI2A PF05399.11 EFC39642.1 - 2.9 7.4 5.1 9.7 5.7 5.1 1.8 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) FAM199X PF15814.5 EFC39643.1 - 0.023 13.8 2.5 0.038 13.1 2.5 1.4 1 0 0 1 1 1 0 Protein family FAM199X SR-25 PF10500.9 EFC39643.1 - 2.6 7.6 25.2 0.083 12.5 17.4 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Med3 PF11593.8 EFC39643.1 - 3.3 6.8 17.7 5.2 6.2 17.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal ABC_tran PF00005.27 EFC39644.1 - 3.5e-33 115.0 0.0 6e-33 114.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC39644.1 - 2e-07 30.7 2.0 0.0001 21.8 0.1 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC39644.1 - 0.00017 21.3 0.1 0.00044 19.9 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 EFC39644.1 - 0.00038 20.9 0.3 0.15 12.5 0.1 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFC39644.1 - 0.0005 20.0 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFC39644.1 - 0.00066 20.1 0.9 0.0041 17.5 0.9 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC39644.1 - 0.0022 18.3 0.3 0.097 12.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFC39644.1 - 0.0039 16.9 1.1 0.11 12.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 EFC39644.1 - 0.004 16.9 0.0 0.0088 15.8 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 EFC39644.1 - 0.0054 16.7 0.2 0.093 12.7 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 EFC39644.1 - 0.011 15.7 0.1 0.13 12.1 0.0 2.4 3 0 0 3 3 3 0 Rad17 P-loop domain ABC_ATPase PF09818.9 EFC39644.1 - 0.013 14.4 0.6 0.018 13.8 0.0 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Zeta_toxin PF06414.12 EFC39644.1 - 0.015 14.6 0.0 0.11 11.7 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 EFC39644.1 - 0.015 15.8 0.5 0.037 14.6 0.1 2.0 2 1 0 2 2 1 0 AAA domain AAA_21 PF13304.6 EFC39644.1 - 0.018 14.8 0.4 1.3 8.8 0.2 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 EFC39644.1 - 0.027 14.6 0.2 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EFC39644.1 - 0.043 13.3 0.1 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region G-alpha PF00503.20 EFC39644.1 - 0.047 12.8 0.0 0.088 12.0 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit AAA_24 PF13479.6 EFC39644.1 - 0.073 12.8 0.2 0.35 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 EFC39644.1 - 0.086 13.1 0.6 0.59 10.4 0.6 2.1 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 EFC39644.1 - 0.1 12.1 0.2 4 7.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFC39644.1 - 0.11 12.4 0.1 0.93 9.4 0.0 2.3 2 0 0 2 2 2 0 Adenylylsulphate kinase GTP_EFTU PF00009.27 EFC39645.1 - 9.5e-29 100.3 0.0 1.4e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC39645.1 - 4.4e-19 68.8 0.0 9e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC39645.1 - 1.9e-10 41.0 0.4 2e-09 37.7 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 EFC39645.1 - 0.001 19.0 0.1 0.002 18.0 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 EFC39645.1 - 0.0021 18.1 0.0 0.0068 16.5 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase PSCyt3 PF07627.11 EFC39647.1 - 0.015 15.5 4.0 0.015 15.5 4.0 2.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1588) tRNA-synt_1 PF00133.22 EFC39648.1 - 1.1e-91 308.0 0.0 1.3e-91 307.7 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFC39648.1 - 0.0013 17.5 0.5 0.054 12.2 0.3 2.3 2 1 0 2 2 2 2 tRNA synthetases class I (M) Acetyltransf_1 PF00583.25 EFC39649.1 - 9.4e-10 38.7 0.1 1.6e-09 38.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFC39649.1 - 5.1e-07 29.8 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC39649.1 - 5.2e-07 29.5 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EFC39649.1 - 9.9e-06 25.5 0.0 1.9e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC39649.1 - 3.2e-05 24.3 0.0 5.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC39649.1 - 0.00087 18.8 0.2 0.0018 17.8 0.2 1.6 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 EFC39649.1 - 0.0074 16.4 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 EFC39649.1 - 0.011 16.5 0.0 0.019 15.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ubiquitin PF00240.23 EFC39650.1 - 6e-34 115.6 1.2 8.6e-34 115.1 0.7 1.5 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 EFC39650.1 - 1.4e-19 69.9 5.9 1.4e-19 69.9 5.9 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 EFC39650.1 - 1.2e-16 60.3 0.7 1.8e-16 59.7 0.7 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC39650.1 - 2.3e-05 24.7 0.2 9e-05 22.9 0.2 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC39650.1 - 2.9e-05 24.1 1.3 0.00019 21.5 1.0 2.2 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC39650.1 - 0.0032 17.4 0.1 0.0049 16.8 0.1 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC39650.1 - 0.0033 17.7 1.7 0.0035 17.6 0.2 1.8 1 1 1 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 EFC39650.1 - 0.0038 17.7 0.8 0.0053 17.3 0.8 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC39650.1 - 0.0041 17.1 2.9 1.8 8.7 0.2 2.9 3 0 0 3 3 3 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC39650.1 - 0.0082 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain TFIIA PF03153.13 EFC39651.1 - 1.3e-50 173.6 11.7 1.9e-36 127.0 10.5 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Sigma70_ner PF04546.13 EFC39651.1 - 1.3 8.8 7.5 2.4 8.0 7.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 EFC39651.1 - 2.5 6.2 13.7 3.5 5.7 13.7 1.1 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 EFC39651.1 - 2.6 7.5 11.8 0.5 9.9 6.8 1.9 2 0 0 2 2 2 0 PPP4R2 CDC45 PF02724.14 EFC39651.1 - 3.4 5.8 11.2 5.2 5.2 11.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 EFC39651.1 - 5.2 5.0 19.7 7.4 4.5 19.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi VapB_antitoxin PF09957.9 EFC39652.1 - 0.054 13.4 0.5 0.16 11.9 0.2 1.9 2 0 0 2 2 2 0 Bacterial antitoxin of type II TA system, VapB Sep15_SelM PF08806.11 EFC39652.1 - 0.062 13.5 0.2 4.5 7.5 0.1 3.2 3 0 0 3 3 3 0 Sep15/SelM redox domain dCache_1 PF02743.18 EFC39653.1 - 1.5e-05 24.9 2.7 4e-05 23.5 2.7 1.7 1 0 0 1 1 1 1 Cache domain Guanylate_cyc PF00211.20 EFC39653.1 - 3.7e-05 23.4 0.2 0.0023 17.6 0.1 2.4 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain ATP_bind_1 PF03029.17 EFC39653.1 - 0.054 13.3 0.1 0.15 11.8 0.1 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein Baculo_11_kDa PF06143.11 EFC39653.1 - 0.067 12.8 0.5 0.19 11.3 0.5 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family RP-C_C PF11800.8 EFC39653.1 - 0.77 9.8 3.0 0.39 10.8 0.2 1.8 2 0 0 2 2 2 0 Replication protein C C-terminal region LPAM_1 PF08139.12 EFC39654.1 - 0.0012 19.2 1.6 0.0019 18.5 1.6 1.3 1 0 0 1 1 1 1 Prokaryotic membrane lipoprotein lipid attachment site YvfG PF09628.10 EFC39654.1 - 0.13 12.7 0.5 0.23 11.9 0.5 1.3 1 0 0 1 1 1 0 YvfG protein RAMP PF04901.13 EFC39656.1 - 0.065 13.2 1.1 0.28 11.2 0.0 2.4 2 1 0 2 2 2 0 Receptor activity modifying family Glucan_synthase PF02364.15 EFC39656.1 - 0.24 9.5 6.3 0.029 12.6 2.5 1.3 2 0 0 2 2 2 0 1,3-beta-glucan synthase component DUF5090 PF17009.5 EFC39656.1 - 6.6 6.7 15.5 9.6 6.1 15.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) TssN PF17555.2 EFC39656.1 - 8.7 5.6 15.6 13 5.1 15.6 1.3 1 0 0 1 1 1 0 Type VI secretion system, TssN Laminin_G_3 PF13385.6 EFC39657.1 - 5.3e-18 65.6 0.0 8e-18 65.0 0.0 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF1080 PF06439.11 EFC39657.1 - 0.021 14.9 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) Pentaxin PF00354.17 EFC39657.1 - 0.073 12.7 0.2 0.29 10.8 0.2 2.0 1 1 0 1 1 1 0 Pentaxin family adh_short PF00106.25 EFC39658.1 - 8.5e-37 126.5 0.0 4.8e-26 91.4 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39658.1 - 6e-24 84.9 0.0 2e-18 66.8 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39658.1 - 0.0013 18.7 0.1 0.012 15.5 0.1 2.0 2 0 0 2 2 2 1 KR domain Peptidase_S8 PF00082.22 EFC39659.1 - 1.9e-38 132.4 6.7 7.9e-38 130.4 6.7 1.9 1 1 0 1 1 1 1 Subtilase family YdaT_toxin PF06254.11 EFC39660.1 - 0.026 15.1 0.1 0.059 14.0 0.1 1.6 1 0 0 1 1 1 0 Putative bacterial toxin ydaT Arf PF00025.21 EFC39661.1 - 5.3e-64 214.9 0.1 6e-64 214.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC39661.1 - 4.8e-14 52.3 0.0 5.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC39661.1 - 3.4e-12 46.6 0.1 4.7e-12 46.2 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC39661.1 - 1.2e-11 44.4 1.7 1.6e-08 34.1 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC39661.1 - 2.3e-10 40.2 0.0 2.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC39661.1 - 5.3e-07 29.2 0.0 6.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC39661.1 - 0.00037 20.5 0.0 0.00057 19.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arabinose_Iso_C PF11762.8 EFC39661.1 - 0.18 11.7 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 L-arabinose isomerase C-terminal domain Pkinase PF00069.25 EFC39662.1 - 3.6e-11 43.0 0.1 1e-10 41.5 0.1 1.8 1 0 0 1 1 1 1 Protein kinase domain DUF4116 PF13475.6 EFC39662.1 - 2e-07 30.6 44.7 0.0074 16.0 2.3 9.3 7 3 1 8 8 8 4 Domain of unknown function (DUF4116) RCC1_2 PF13540.6 EFC39662.1 - 1e-05 25.2 0.1 2.1e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 EFC39662.1 - 6.3e-05 22.4 0.0 0.00011 21.5 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase SopA PF13981.6 EFC39662.1 - 0.012 16.0 1.7 2.7 8.5 0.1 2.8 2 0 0 2 2 2 0 SopA-like central domain RCC1 PF00415.18 EFC39662.1 - 0.046 14.3 0.6 1.9 9.2 0.1 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Glyco_hydro_4C PF11975.8 EFC39662.1 - 0.12 12.4 0.4 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 Family 4 glycosyl hydrolase C-terminal domain EF-G-binding_N PF07299.11 EFC39662.1 - 2.6 8.6 10.3 4.8 7.8 0.3 4.2 4 0 0 4 4 4 0 Elongation factor G-binding protein, N-terminal REJ PF02010.15 EFC39663.1 - 8.4e-45 153.4 7.9 8.4e-45 153.4 7.9 3.4 3 1 0 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC39663.1 - 1.1e-27 96.1 338.1 0.00013 22.3 7.7 23.3 21 2 0 21 21 21 16 EGF-like domain Cullin PF00888.22 EFC39663.1 - 0.14 10.8 0.2 0.2 10.2 0.2 1.1 1 0 0 1 1 1 0 Cullin family Guanylate_cyc PF00211.20 EFC39664.1 - 3.8e-34 117.9 1.0 9.9e-34 116.6 1.0 1.7 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC39664.1 - 2.7e-20 72.5 0.0 4.2e-11 42.8 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC39664.1 - 6.4e-15 55.3 1.1 8e-09 35.7 0.1 3.3 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 EFC39664.1 - 4.1e-09 36.7 0.0 0.00015 22.0 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_10 PF13596.6 EFC39664.1 - 0.00064 20.3 0.0 2.8 8.6 0.0 3.1 2 0 0 2 2 2 2 PAS domain DUF4778 PF16008.5 EFC39664.1 - 0.0033 17.5 2.7 0.0064 16.6 2.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4778) PAS_8 PF13188.7 EFC39664.1 - 0.032 14.3 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 PAS domain PAS_2 PF08446.11 EFC39664.1 - 0.046 14.4 0.2 0.51 11.0 0.0 2.7 3 0 0 3 3 3 0 PAS fold DUF2263 PF10021.9 EFC39665.1 - 1.2e-27 97.1 0.7 6.3e-27 94.7 0.0 2.4 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2263) Pkinase PF00069.25 EFC39666.1 - 3.2e-65 220.1 0.0 4.4e-65 219.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39666.1 - 2.5e-30 105.6 0.0 4.7e-30 104.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 EFC39666.1 - 4.8e-24 84.5 2.4 4.8e-24 84.5 2.4 1.6 2 0 0 2 2 2 1 PH domain FTA2 PF13095.6 EFC39666.1 - 0.0015 18.2 0.8 0.27 10.8 0.4 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EFC39666.1 - 0.06 12.7 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Sushi_2 PF09014.10 EFC39666.1 - 0.08 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain Pkinase_fungal PF17667.1 EFC39666.1 - 0.084 11.6 0.0 0.14 10.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 EFC39666.1 - 0.16 11.9 0.0 0.48 10.3 0.0 1.6 1 1 0 2 2 2 0 Phosphotransferase enzyme family Med21 PF11221.8 EFC39667.1 - 0.01 16.1 2.2 0.032 14.5 2.2 1.8 1 1 1 2 2 2 0 Subunit 21 of Mediator complex Amidase PF01425.21 EFC39667.1 - 0.018 14.0 0.0 0.045 12.7 0.0 1.5 2 0 0 2 2 2 0 Amidase SlyX PF04102.12 EFC39667.1 - 1.6 9.4 10.4 5.1 7.8 1.9 3.3 2 1 1 3 3 3 0 SlyX FlxA PF14282.6 EFC39667.1 - 2.7 8.1 8.5 8.2 6.5 1.3 2.6 2 1 0 2 2 2 0 FlxA-like protein zf-CCCH PF00642.24 EFC39668.1 - 3.7e-05 23.5 11.8 0.00041 20.2 0.3 2.8 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFC39668.1 - 0.0045 16.7 12.0 0.28 11.0 5.5 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFC39668.1 - 2.6 8.2 12.0 2.2 8.4 1.2 3.1 2 1 0 2 2 2 0 Zinc finger domain DUF2868 PF11067.8 EFC39668.1 - 5.9 6.3 4.9 5.4 6.4 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2868) Ku PF02735.16 EFC39669.1 - 2.2e-43 148.4 0.1 4.7e-43 147.3 0.1 1.6 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_PK_bind PF08785.11 EFC39669.1 - 2.1e-41 140.8 2.9 5.5e-41 139.5 2.9 1.8 1 0 0 1 1 1 1 Ku C terminal domain like Ku_N PF03731.15 EFC39669.1 - 1.6e-15 57.5 0.3 1.6e-15 57.5 0.3 2.4 3 0 0 3 3 3 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 EFC39669.1 - 2.6e-06 28.0 0.2 1.5e-05 25.6 0.2 2.4 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm DUF3105 PF11303.8 EFC39670.1 - 0.019 15.1 0.0 0.042 14.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3105) LRR_4 PF12799.7 EFC39671.1 - 2.5e-09 37.2 4.8 4.3e-05 23.8 0.7 3.1 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39671.1 - 4.2e-09 36.0 2.7 0.0004 20.1 0.0 2.5 2 1 0 2 2 2 2 Leucine rich repeat LRR_6 PF13516.6 EFC39671.1 - 6e-08 32.1 1.9 0.033 14.2 0.0 4.2 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 EFC39671.1 - 0.00035 20.7 3.7 3.5 8.5 0.0 4.2 3 1 0 3 3 3 2 Leucine Rich Repeat cobW PF02492.19 EFC39671.1 - 0.079 12.5 0.5 0.093 12.3 0.5 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain EGF_2 PF07974.13 EFC39672.1 - 1.8e-90 296.9 642.0 0.00013 22.2 8.0 40.5 39 1 1 40 40 40 39 EGF-like domain APH PF01636.23 EFC39673.1 - 7e-36 124.3 0.0 1.3e-35 123.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_1 PF00441.24 EFC39673.1 - 5.1e-34 117.6 4.0 8.3e-34 117.0 4.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFC39673.1 - 7.7e-17 61.3 0.0 2.2e-16 59.8 0.0 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFC39673.1 - 2.1e-12 47.4 3.9 1.4e-11 44.8 4.1 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFC39673.1 - 3.1e-12 47.2 0.0 6.5e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain EcKinase PF02958.20 EFC39673.1 - 1.1e-06 28.2 0.2 2.5e-06 27.0 0.2 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 EFC39673.1 - 0.0037 16.9 0.2 0.0085 15.7 0.2 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase DHR-2 PF06920.13 EFC39674.1 - 9.2e-24 84.0 27.1 5.3e-23 81.5 27.1 2.3 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 EFC39674.1 - 2.4e-05 24.2 1.4 2.4e-05 24.2 1.4 3.1 3 0 0 3 3 3 1 C2 domain in Dock180 and Zizimin proteins SEA PF01390.20 EFC39674.1 - 0.0071 16.4 0.7 0.064 13.4 0.7 2.7 1 0 0 1 1 1 1 SEA domain Guanylate_cyc PF00211.20 EFC39675.1 - 4.7e-53 179.5 0.1 1.4e-52 178.0 0.1 1.9 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC39675.1 - 4.9e-12 46.0 1.2 2.1e-11 44.0 0.2 2.7 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 EFC39675.1 - 2.9e-05 24.0 0.0 5.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC39675.1 - 0.0066 15.9 0.2 0.0066 15.9 0.2 2.1 2 0 0 2 2 2 1 Heme NO binding associated PAS_10 PF13596.6 EFC39675.1 - 0.013 16.1 0.1 0.058 14.0 0.0 2.1 2 0 0 2 2 2 0 PAS domain zf-AD PF07776.15 EFC39675.1 - 0.058 13.6 0.9 25 5.2 0.2 4.0 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) TIM21 PF08294.11 EFC39675.1 - 0.33 10.8 2.7 12 5.8 0.3 2.8 2 0 0 2 2 2 0 TIM21 Fibrinogen_C PF00147.18 EFC39678.1 - 2.5e-06 27.5 0.0 6.2e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.13 EFC39678.1 - 0.00036 20.9 6.3 0.00036 20.9 6.3 3.0 2 1 0 2 2 2 1 EGF-like domain EFG_C PF00679.24 EFC39678.1 - 0.15 12.1 0.0 0.51 10.4 0.0 1.9 1 0 0 1 1 1 0 Elongation factor G C-terminus RGS PF00615.19 EFC39681.1 - 3.9e-06 27.1 3.1 1.1e-05 25.6 3.1 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain DDE_Tnp_1_5 PF13737.6 EFC39681.1 - 0.044 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Transposase DDE domain DUF563 PF04577.14 EFC39682.1 - 6.8e-18 65.6 1.3 1.3e-17 64.7 0.7 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF563) Ipi1_N PF12333.8 EFC39683.1 - 0.088 13.4 1.1 6.8 7.4 0.0 2.5 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation G-alpha PF00503.20 EFC39685.1 - 1.9e-06 27.3 3.0 1.9e-06 27.3 3.0 4.2 2 1 0 2 2 2 1 G-protein alpha subunit Metallopep PF12044.8 EFC39686.1 - 9e-63 212.3 0.2 1.2e-62 211.9 0.2 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 EFC39686.1 - 0.0018 18.5 0.9 0.0058 16.8 0.0 2.4 3 0 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EFC39686.1 - 0.026 15.1 0.0 0.091 13.3 0.0 2.0 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like AAT PF03417.16 EFC39687.1 - 3.9e-18 66.0 0.0 9.1e-18 64.8 0.0 1.6 1 1 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Helicase_C PF00271.31 EFC39688.1 - 1.1e-06 29.0 1.5 0.0005 20.4 0.1 3.0 3 1 0 3 3 3 2 Helicase conserved C-terminal domain DEAD PF00270.29 EFC39688.1 - 0.00083 19.2 0.1 0.0023 17.7 0.1 1.8 1 1 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 EFC39688.1 - 0.13 11.6 0.0 0.34 10.2 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 EFC39689.1 - 1.5e-05 24.8 0.0 2.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC39689.1 - 0.0016 18.8 0.9 0.014 15.7 0.1 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EFC39689.1 - 0.03 13.7 0.1 0.14 11.4 0.0 1.9 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Macoilin PF09726.9 EFC39691.1 - 0.49 8.9 20.7 0.63 8.5 20.7 1.1 1 0 0 1 1 1 0 Macoilin family RGS PF00615.19 EFC39692.1 - 1.4e-15 57.6 1.5 7.8e-14 52.0 0.9 3.4 2 1 0 2 2 2 1 Regulator of G protein signaling domain START PF01852.19 EFC39692.1 - 2e-06 27.4 0.0 3.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 START domain Ank_2 PF12796.7 EFC39693.1 - 2.4e-11 44.0 0.6 4.6e-05 23.9 0.0 4.7 3 1 2 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC39693.1 - 2e-06 28.2 0.0 0.0099 16.4 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC39693.1 - 0.0018 18.6 0.0 6 7.8 0.0 4.5 5 0 0 5 5 5 1 Ankyrin repeat CHASE PF03924.13 EFC39695.1 - 0.00021 21.3 0.0 0.00042 20.3 0.0 1.4 1 0 0 1 1 1 1 CHASE domain PAS_8 PF13188.7 EFC39695.1 - 0.015 15.3 0.0 0.037 14.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain Peptidase_C1 PF00112.23 EFC39696.1 - 2.8e-55 187.7 10.2 3.5e-55 187.5 10.2 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC39696.1 - 1e-05 24.5 2.7 0.012 14.4 0.0 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC39696.1 - 0.0026 17.6 0.0 0.0055 16.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide WD40 PF00400.32 EFC39697.1 - 1.9e-17 63.3 0.3 7.6e-05 23.4 0.0 5.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC39697.1 - 0.00035 20.8 0.0 2.7 8.4 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain G-alpha PF00503.20 EFC39698.1 - 9.6e-11 41.4 11.9 1.5e-10 40.8 11.9 1.2 1 0 0 1 1 1 1 G-protein alpha subunit PhnJ PF06007.11 EFC39698.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnJ RGS PF00615.19 EFC39699.1 - 4.5e-16 59.2 7.8 8.4e-16 58.3 7.8 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain TBCC PF07986.12 EFC39699.1 - 0.023 14.4 0.7 0.049 13.4 0.5 1.7 1 1 0 1 1 1 0 Tubulin binding cofactor C DUF5644 PF18712.1 EFC39699.1 - 0.056 13.4 0.8 0.14 12.2 0.3 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5644) IBN_N PF03810.19 EFC39699.1 - 0.062 13.2 5.1 0.088 12.7 0.3 2.7 3 0 0 3 3 3 0 Importin-beta N-terminal domain BLUF PF04940.12 EFC39700.1 - 6.4e-23 80.7 0.2 1.5e-22 79.5 0.1 1.7 2 0 0 2 2 2 1 Sensors of blue-light using FAD Guanylate_cyc PF00211.20 EFC39700.1 - 1.6e-22 80.0 1.1 2.4e-22 79.4 1.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pneumovirus_M2 PF06436.11 EFC39700.1 - 0.07 12.6 0.2 0.14 11.6 0.2 1.5 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) START PF01852.19 EFC39701.1 - 0.00021 20.8 0.0 0.0011 18.4 0.0 2.0 1 1 0 1 1 1 1 START domain Reprolysin_2 PF13574.6 EFC39702.1 - 0.16 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Cofilin_ADF PF00241.20 EFC39703.1 - 5e-22 78.0 0.3 5.7e-22 77.8 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein C2 PF00168.30 EFC39704.1 - 3.6e-16 59.3 0.1 4.5e-16 59.0 0.1 1.1 1 0 0 1 1 1 1 C2 domain UPF0060 PF02694.15 EFC39706.1 - 0.075 13.3 2.6 0.13 12.5 2.6 1.4 1 0 0 1 1 1 0 Uncharacterised BCR, YnfA/UPF0060 family TPR_12 PF13424.6 EFC39707.1 - 0.00054 20.2 0.0 1.3 9.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat SoxE PF06525.11 EFC39707.1 - 0.00089 18.8 0.4 0.002 17.7 0.4 1.5 1 0 0 1 1 1 1 Sulfocyanin (SoxE) domain TPR_1 PF00515.28 EFC39707.1 - 0.084 12.7 0.6 34 4.5 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat IQ PF00612.27 EFC39707.1 - 0.32 10.9 4.0 0.35 10.8 1.6 2.2 2 0 0 2 2 2 0 IQ calmodulin-binding motif MT-A70 PF05063.14 EFC39708.1 - 1.3e-36 126.1 0.2 2.6e-36 125.1 0.2 1.5 1 0 0 1 1 1 1 MT-A70 CDRT4 PF15213.6 EFC39708.1 - 0.014 16.0 2.4 0.014 16.0 2.4 2.9 3 0 0 3 3 3 0 CMT1A duplicated region transcript 4 protein YL1 PF05764.13 EFC39708.1 - 0.38 10.8 30.4 2.3 8.2 1.7 2.4 2 0 0 2 2 2 0 YL1 nuclear protein BUD22 PF09073.10 EFC39708.1 - 2.5 7.3 37.7 0.37 10.1 3.4 2.2 2 0 0 2 2 2 0 BUD22 NST1 PF13945.6 EFC39708.1 - 4.4 7.4 31.9 0.72 9.9 3.4 2.8 3 0 0 3 3 3 0 Salt tolerance down-regulator DUF4116 PF13475.6 EFC39709.1 - 7.2e-86 281.8 37.6 1.2e-11 44.1 0.1 14.5 6 5 7 13 13 13 13 Domain of unknown function (DUF4116) HBB PF06777.11 EFC39709.1 - 0.075 12.7 0.5 0.22 11.2 0.5 1.9 1 1 0 1 1 1 0 Helical and beta-bridge domain DUF2968 PF11180.8 EFC39710.1 - 0.0042 16.7 6.9 0.0079 15.8 6.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2968) MCPsignal PF00015.21 EFC39710.1 - 0.0057 16.5 0.5 0.0057 16.5 0.5 2.1 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Phage_Mu_Gam PF07352.12 EFC39710.1 - 0.0098 15.8 1.1 0.0098 15.8 1.1 2.3 3 0 0 3 3 3 1 Bacteriophage Mu Gam like protein FlaC_arch PF05377.11 EFC39710.1 - 0.06 13.8 0.5 0.06 13.8 0.5 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 EFC39710.1 - 0.085 12.9 14.4 0.067 13.2 3.5 2.3 1 1 1 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.15 EFC39710.1 - 0.38 10.3 6.3 0.56 9.7 6.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit SLED PF12140.8 EFC39710.1 - 1.2 9.7 5.2 0.72 10.4 0.7 2.5 1 1 1 2 2 2 0 SLED domain zf-CRD PF17979.1 EFC39710.1 - 1.9 8.6 7.5 0.56 10.3 0.7 2.5 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions LMBR1 PF04791.16 EFC39710.1 - 4 6.2 8.4 11 4.8 8.6 1.7 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF948 PF06103.11 EFC39710.1 - 8.5 6.7 8.9 1.8 8.9 1.6 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) RCC1_2 PF13540.6 EFC39711.1 - 1.9e-05 24.3 0.0 4.8e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RGS PF00615.19 EFC39711.1 - 7.2e-05 23.0 2.9 0.00014 22.2 1.1 2.4 3 0 0 3 3 3 1 Regulator of G protein signaling domain RCC1 PF00415.18 EFC39711.1 - 8.5e-05 23.1 0.1 0.74 10.5 0.0 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat DUF5023 PF16426.5 EFC39711.1 - 0.083 12.5 0.3 0.14 11.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5023) Pyr_redox_2 PF07992.14 EFC39712.1 - 1.3e-46 159.2 0.0 1.8e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC39712.1 - 1.6e-12 47.8 0.1 1e-10 42.0 0.0 2.9 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Clp1 PF06807.14 EFC39712.1 - 0.006 17.0 0.1 0.014 15.8 0.1 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 DAO PF01266.24 EFC39712.1 - 0.046 13.3 0.0 0.17 11.4 0.0 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 EFC39712.1 - 0.48 9.6 6.1 6.4 5.9 0.2 3.1 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase TPR_12 PF13424.6 EFC39715.1 - 0.05 13.9 0.0 0.49 10.7 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat IalB PF06776.12 EFC39715.1 - 0.064 13.3 0.0 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 Invasion associated locus B (IalB) protein Chromo PF00385.24 EFC39716.1 - 3.7e-13 49.2 0.7 8.3e-13 48.0 0.7 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain QLQ PF08880.11 EFC39716.1 - 0.00044 19.9 0.1 0.0009 19.0 0.1 1.5 1 0 0 1 1 1 1 QLQ CdiA_C PF18451.1 EFC39717.1 - 1.5 9.1 7.7 0.36 11.1 1.9 2.6 2 1 1 3 3 3 0 Contact-dependent growth inhibition CdiA C-terminal domain DUF4724 PF15852.5 EFC39717.1 - 4.6 7.8 14.3 0.065 13.7 1.5 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4724) Methyltransf_25 PF13649.6 EFC39719.1 - 2.2e-12 47.5 1.2 2e-07 31.6 0.1 2.9 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFC39719.1 - 5.2e-12 46.3 0.4 3e-09 37.4 0.2 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC39719.1 - 8.9e-11 41.9 0.0 3.9e-10 39.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC39719.1 - 3.1e-10 40.7 1.2 2.3e-08 34.7 0.3 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC39719.1 - 2.6e-09 37.1 1.7 1.6e-07 31.2 1.7 2.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC39719.1 - 0.00028 20.3 0.0 0.018 14.4 0.0 2.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFC39719.1 - 0.0031 17.0 0.0 0.052 13.0 0.0 2.5 2 1 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EFC39719.1 - 0.024 14.2 0.1 1.8 8.1 0.0 2.5 1 1 1 2 2 2 0 Methyltransferase small domain TPMT PF05724.11 EFC39719.1 - 0.053 13.2 0.0 0.15 11.7 0.0 1.8 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) ABC_membrane PF00664.23 EFC39720.1 - 4.7e-57 193.7 33.6 4.3e-31 108.6 21.8 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFC39720.1 - 5.6e-49 166.2 0.2 1.3e-29 103.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFC39720.1 - 6.1e-07 29.1 11.4 0.0005 19.6 0.2 3.8 2 2 0 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC39720.1 - 4.6e-06 26.6 0.0 0.03 14.3 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC39720.1 - 7.9e-06 25.9 1.0 0.15 12.2 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC39720.1 - 1.5e-05 24.6 1.8 0.16 11.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC39720.1 - 0.0011 19.4 0.1 0.31 11.4 0.0 2.9 3 0 0 3 3 2 1 AAA ATPase domain AAA_21 PF13304.6 EFC39720.1 - 0.0014 18.5 6.5 0.082 12.7 0.5 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 EFC39720.1 - 0.0029 17.4 0.3 0.46 10.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFC39720.1 - 0.0066 16.7 0.4 4.7 7.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_23 PF13476.6 EFC39720.1 - 0.0083 16.7 9.1 0.15 12.5 0.3 3.2 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 EFC39720.1 - 0.0094 16.3 0.3 32 5.0 0.0 3.8 3 0 0 3 3 3 0 RNA helicase Roc PF08477.13 EFC39720.1 - 0.011 15.9 1.2 6.5 7.0 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFC39720.1 - 0.019 15.0 1.8 1 9.4 0.0 2.8 2 0 0 2 2 2 0 Dynamin family AAA_7 PF12775.7 EFC39720.1 - 0.025 14.1 0.1 3.5 7.1 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region RdRP PF05183.12 EFC39720.1 - 0.08 11.6 0.1 0.14 10.7 0.1 1.3 1 0 0 1 1 1 0 RNA dependent RNA polymerase DEAD PF00270.29 EFC39720.1 - 0.11 12.3 0.1 19 5.0 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_5 PF07728.14 EFC39720.1 - 0.12 12.3 0.3 25 4.9 0.0 3.5 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 EFC39720.1 - 0.13 12.2 0.1 19 5.1 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EFC39720.1 - 0.13 11.8 0.0 16 5.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFC39720.1 - 0.13 11.9 0.0 4.2 7.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 EFC39720.1 - 2 8.4 9.5 4.7 7.2 0.1 3.7 3 1 1 4 4 4 0 Helicase HerA, central domain 2OG-FeII_Oxy_2 PF13532.6 EFC39721.1 - 6.1e-31 108.1 0.0 4.4e-29 102.1 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_hydro_15 PF00723.21 EFC39722.1 - 0.063 12.0 0.1 0.73 8.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl hydrolases family 15 Aldedh PF00171.22 EFC39723.1 - 2.5e-170 567.0 0.1 2.9e-170 566.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pkinase_Tyr PF07714.17 EFC39724.1 - 3.8e-50 170.6 0.2 4.6e-48 163.8 0.1 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFC39724.1 - 9.2e-47 159.6 0.2 1.7e-46 158.7 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Beta_helix PF13229.6 EFC39724.1 - 1.1e-13 51.4 32.5 3.9e-09 36.5 17.5 3.9 1 1 2 3 3 3 3 Right handed beta helix region NosD PF05048.13 EFC39724.1 - 3.3e-07 29.8 37.7 9.4e-06 25.1 19.3 3.3 1 1 3 4 4 4 3 Periplasmic copper-binding protein (NosD) Haspin_kinase PF12330.8 EFC39724.1 - 1.7e-05 24.0 0.2 4e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC39724.1 - 0.03 14.2 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3808 PF10300.9 EFC39725.1 - 0.036 12.8 0.0 0.042 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Pkinase PF00069.25 EFC39726.1 - 6.8e-51 173.2 1.1 1.5e-50 172.0 1.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39726.1 - 2.5e-34 118.8 0.4 4.6e-34 117.9 0.4 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC39726.1 - 0.0043 16.4 0.4 0.01 15.2 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC39726.1 - 0.0066 15.3 0.0 0.0066 15.3 0.0 2.5 2 1 0 2 2 2 1 Fungal protein kinase DUF3874 PF12990.7 EFC39726.1 - 0.1 13.0 0.6 0.31 11.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknonw function from B. Theta Gene description (DUF3874) SF3A3 PF16837.5 EFC39726.1 - 0.15 12.6 0.7 0.88 10.1 0.0 2.6 3 0 0 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 CTP_transf_like PF01467.26 EFC39727.1 - 1.3e-43 148.6 0.2 3.5e-26 92.1 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 EFC39727.1 - 2.8e-07 30.6 2.0 0.0066 16.4 0.1 3.4 2 1 0 2 2 2 2 FAD synthetase DUF4209 PF13910.6 EFC39729.1 - 2.2e-27 95.1 2.4 2.5e-26 91.7 0.3 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF4209) cNMP_binding PF00027.29 EFC39730.1 - 2.6e-12 46.7 0.0 1.4e-08 34.7 0.1 4.0 3 1 0 3 3 3 2 Cyclic nucleotide-binding domain HEAT_EZ PF13513.6 EFC39731.1 - 1.8e-28 98.6 3.0 9.7e-13 48.3 0.0 10.2 9 1 1 10 10 10 3 HEAT-like repeat HEAT PF02985.22 EFC39731.1 - 1.1e-15 56.4 9.0 0.29 11.5 0.0 10.4 10 0 0 10 10 10 3 HEAT repeat Cnd1 PF12717.7 EFC39731.1 - 2.9e-10 40.4 0.0 0.033 14.2 0.0 4.7 3 1 2 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC39731.1 - 5e-09 36.4 0.0 0.00084 19.7 0.0 5.7 4 2 0 5 5 5 1 HEAT repeats IBN_N PF03810.19 EFC39731.1 - 1.3e-08 34.6 1.9 1.6e-07 31.1 0.1 3.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 EFC39731.1 - 7.3e-08 32.9 0.2 0.0016 19.0 0.0 5.4 4 3 1 5 5 5 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFC39731.1 - 4.7e-06 26.3 0.0 1.3 8.6 0.0 4.4 3 2 0 3 3 3 2 CLASP N terminal Arm PF00514.23 EFC39731.1 - 1.4e-05 24.9 2.3 4.6 7.4 0.0 6.4 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 EFC39731.1 - 9.4e-05 21.2 0.9 1.3 7.5 0.2 3.9 3 2 1 4 4 4 3 Adaptin N terminal region DUF3437 PF11919.8 EFC39731.1 - 0.0004 20.2 0.0 0.094 12.6 0.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) TFCD_C PF12612.8 EFC39731.1 - 0.043 13.6 0.0 18 5.1 0.0 3.0 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal Xpo1 PF08389.12 EFC39731.1 - 0.57 10.2 4.7 13 5.8 0.5 4.5 4 1 0 4 4 4 0 Exportin 1-like protein E1-E2_ATPase PF00122.20 EFC39732.1 - 0.81 9.2 11.0 0.088 12.3 5.0 2.1 2 0 0 2 2 2 0 E1-E2 ATPase START PF01852.19 EFC39733.1 - 1.2e-12 47.7 0.1 1.5e-12 47.4 0.1 1.0 1 0 0 1 1 1 1 START domain Polyketide_cyc PF03364.20 EFC39733.1 - 0.058 13.6 0.2 0.53 10.5 0.2 2.0 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport DUF996 PF06195.13 EFC39734.1 - 9.8 6.5 12.6 2.2 8.6 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF996) RPEL PF02755.15 EFC39735.1 - 1.4e-07 31.0 6.2 4.7e-06 26.1 0.3 3.6 3 0 0 3 3 3 3 RPEL repeat Peptidase_C97 PF05903.14 EFC39736.1 - 8.9e-23 80.8 0.0 1.8e-22 79.8 0.0 1.5 1 1 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EFC39736.1 - 0.012 15.9 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 Lecithin retinol acyltransferase SVIP PF15811.5 EFC39736.1 - 0.058 13.8 0.1 0.1 13.0 0.1 1.4 1 0 0 1 1 1 0 Small VCP/p97-interacting protein WLM PF08325.10 EFC39736.1 - 0.45 10.6 1.6 0.52 10.4 0.4 1.6 2 0 0 2 2 2 0 WLM domain F-box-like PF12937.7 EFC39737.1 - 0.00046 20.0 0.2 0.0022 17.9 0.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC39737.1 - 0.0043 16.9 1.1 0.02 14.8 0.1 2.7 3 0 0 3 3 3 1 F-box domain LRR_6 PF13516.6 EFC39737.1 - 0.83 9.9 9.6 11 6.4 0.0 4.4 5 0 0 5 5 5 0 Leucine Rich repeat LRR_4 PF12799.7 EFC39737.1 - 5.1 7.7 21.2 0.88 10.1 2.5 5.1 2 2 3 5 5 5 0 Leucine Rich repeats (2 copies) Biopterin_H PF00351.21 EFC39738.1 - 1.7e-157 523.7 0.0 2.1e-157 523.4 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EFC39738.1 - 0.12 12.2 0.1 0.29 11.0 0.1 1.6 1 0 0 1 1 1 0 ACT domain DCP1 PF06058.13 EFC39740.1 - 1.6e-33 115.1 0.4 2.6e-33 114.4 0.4 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family DUF1825 PF08855.10 EFC39740.1 - 0.16 11.9 2.8 2.2 8.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) Aldedh PF00171.22 EFC39741.1 - 5.3e-130 434.0 0.1 6.7e-130 433.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFC39741.1 - 0.077 12.0 2.1 0.67 8.9 2.0 2.2 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) PGK PF00162.19 EFC39742.1 - 2.4e-146 487.5 0.2 2.8e-146 487.3 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase LRR_4 PF12799.7 EFC39743.1 - 1e-12 48.1 47.6 4.8e-05 23.6 1.0 9.8 4 3 8 12 12 12 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39743.1 - 8.4e-09 35.1 40.3 0.0039 16.9 0.1 7.9 4 2 5 9 9 9 8 Leucine rich repeat LRR_6 PF13516.6 EFC39743.1 - 1.7e-07 30.7 24.9 0.047 13.8 0.4 9.7 11 1 0 11 11 11 3 Leucine Rich repeat LRR_9 PF14580.6 EFC39743.1 - 5.1e-06 26.1 12.3 0.00042 19.9 3.0 3.7 2 1 1 3 3 3 2 Leucine-rich repeat F-box-like PF12937.7 EFC39743.1 - 0.027 14.3 0.1 0.07 13.0 0.1 1.7 1 0 0 1 1 1 0 F-box-like LRR_1 PF00560.33 EFC39743.1 - 0.086 13.4 22.0 11 7.0 0.1 9.5 10 0 0 10 10 10 0 Leucine Rich Repeat DUF3899 PF13038.6 EFC39744.1 - 0.045 14.3 0.0 0.045 14.3 0.0 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) Acyltransferase PF01553.21 EFC39745.1 - 2.4e-22 79.0 0.0 6.5e-22 77.6 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase WD40 PF00400.32 EFC39746.1 - 1.6e-50 167.9 15.4 2.8e-10 40.6 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 EFC39746.1 - 1e-37 129.2 5.9 2.2e-37 128.2 5.9 1.6 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 EFC39746.1 - 4e-14 52.7 0.2 0.0073 16.6 0.0 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC39746.1 - 6.1e-06 25.2 4.4 0.021 13.5 0.0 3.7 3 1 0 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFC39746.1 - 0.00017 20.7 0.1 6.9 5.5 0.0 4.1 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH PF08513.11 EFC39746.1 - 0.0099 15.8 0.1 0.024 14.6 0.1 1.7 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 EFC39746.1 - 0.011 15.1 0.0 6 6.1 0.0 3.4 3 1 1 4 4 4 0 WD40-like domain Cwf_Cwc_15 PF04889.12 EFC39746.1 - 3.3 7.4 13.6 0.025 14.3 4.5 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TFIIF_alpha PF05793.12 EFC39746.1 - 5.7 5.4 15.6 0.023 13.3 6.7 1.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BRCT_2 PF16589.5 EFC39747.1 - 3.4e-10 40.2 0.3 2.3e-09 37.5 0.3 2.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 EFC39747.1 - 3e-09 36.9 0.2 0.00075 19.5 0.0 3.0 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 EFC39747.1 - 4.1e-08 33.5 0.8 4.1e-08 33.5 0.8 3.6 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Afi1 PF07792.12 EFC39748.1 - 5 7.6 9.6 3.9 8.0 2.5 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TMEM214 PF10151.9 EFC39749.1 - 0.12 10.8 11.8 0.17 10.3 11.8 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Presenilin PF01080.17 EFC39749.1 - 0.18 10.6 5.5 0.2 10.4 5.5 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 EFC39749.1 - 0.85 8.0 11.3 1.1 7.7 11.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 CFIA_Pcf11 PF11526.8 EFC39749.1 - 0.91 10.1 15.7 0.066 13.7 8.7 2.0 1 1 1 2 2 2 0 Subunit of cleavage factor IA Pcf11 Synaptobrevin PF00957.21 EFC39750.1 - 4.8e-19 67.9 7.1 4.8e-19 67.9 7.1 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 EFC39750.1 - 4.4e-05 23.4 0.0 6.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain LMBR1 PF04791.16 EFC39750.1 - 0.0011 18.0 1.3 0.0012 17.9 1.3 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF2207 PF09972.9 EFC39750.1 - 0.0025 16.6 0.7 0.003 16.4 0.7 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF1676 PF07898.13 EFC39750.1 - 0.003 17.6 0.5 0.0049 16.9 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1676) NACHT PF05729.12 EFC39750.1 - 0.022 14.7 0.2 5 7.0 0.1 2.2 2 0 0 2 2 2 0 NACHT domain Sigma_reg_N PF13800.6 EFC39750.1 - 0.034 14.4 6.6 0.064 13.6 6.6 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal GAT PF03127.14 EFC39750.1 - 0.052 13.9 2.9 0.069 13.5 2.0 1.7 1 1 0 1 1 1 0 GAT domain EMC3_TMCO1 PF01956.16 EFC39750.1 - 0.066 12.9 3.4 0.2 11.4 3.4 1.7 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like YHS PF04945.13 EFC39750.1 - 0.12 12.5 0.2 0.29 11.3 0.2 1.6 1 0 0 1 1 1 0 YHS domain Shisa PF13908.6 EFC39750.1 - 0.22 11.8 0.2 0.35 11.1 0.2 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TPPK_C PF12555.8 EFC39750.1 - 0.73 9.9 4.6 1.5 8.9 4.6 1.5 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal DUF2749 PF10907.8 EFC39750.1 - 1.5 9.0 3.7 3.9 7.7 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) ODV-E18 PF10717.9 EFC39750.1 - 1.6 8.6 5.8 3.1 7.7 5.8 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF4834 PF16118.5 EFC39750.1 - 8.9 7.4 9.3 6 7.9 6.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) LRR_6 PF13516.6 EFC39751.1 - 1.8e-22 77.4 18.0 9.4e-06 25.3 0.0 9.4 9 0 0 9 9 9 5 Leucine Rich repeat LRR_8 PF13855.6 EFC39751.1 - 1.8e-15 56.4 16.6 3.3e-05 23.6 0.7 5.0 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC39751.1 - 8.8e-14 51.4 27.6 0.0063 16.9 1.2 7.2 4 3 4 8 8 8 6 Leucine Rich repeats (2 copies) Lip_prot_lig_C PF10437.9 EFC39751.1 - 2.1e-12 46.9 0.1 6.5e-12 45.3 0.1 1.9 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus LRR_1 PF00560.33 EFC39751.1 - 9.1e-05 22.5 13.5 1.9 9.3 2.2 7.2 6 1 0 6 6 6 2 Leucine Rich Repeat BPL_LplA_LipB PF03099.19 EFC39751.1 - 0.0011 18.9 0.0 0.0079 16.1 0.0 2.2 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family ING PF12998.7 EFC39751.1 - 0.15 12.7 3.5 1.2 9.7 0.2 3.2 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding RhoGEF PF00621.20 EFC39752.1 - 1.4e-36 126.5 2.8 1.4e-36 126.5 2.8 2.5 2 1 0 2 2 2 1 RhoGEF domain GIIM PF08388.11 EFC39752.1 - 0.061 13.4 0.1 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 Group II intron, maturase-specific domain HA PF03457.14 EFC39752.1 - 0.078 13.3 0.0 0.24 11.7 0.0 1.8 1 0 0 1 1 1 0 Helicase associated domain Ribo_biogen_C PF04034.13 EFC39753.1 - 1.8e-54 182.9 0.0 2.8e-54 182.2 0.0 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 EFC39753.1 - 5.5e-09 35.7 0.1 1.3e-08 34.5 0.1 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI GAGA_bind PF06217.12 EFC39753.1 - 0.073 13.3 11.9 0.12 12.7 11.9 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family Nop14 PF04147.12 EFC39753.1 - 3 6.0 45.4 0.091 11.0 26.3 2.0 2 0 0 2 2 2 0 Nop14-like family SID-1_RNA_chan PF13965.6 EFC39753.1 - 8.2 4.7 10.3 12 4.1 10.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hid1 PF12722.7 EFC39753.1 - 9 4.3 15.7 15 3.6 15.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RGCC PF15151.6 EFC39754.1 - 0.97 9.7 8.6 2.6 8.3 8.6 1.7 1 0 0 1 1 1 0 Response gene to complement 32 protein family Gly_transf_sug PF04488.15 EFC39755.1 - 4.5e-12 46.5 1.2 7.4e-12 45.8 1.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif LRR_6 PF13516.6 EFC39758.1 - 4.1e-13 48.2 10.7 0.0047 16.9 0.2 6.9 7 0 0 7 7 7 5 Leucine Rich repeat LRR_4 PF12799.7 EFC39758.1 - 7.2e-13 48.5 15.2 6e-07 29.7 0.7 5.1 2 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39758.1 - 1.8e-12 46.8 9.6 0.00016 21.4 0.6 4.2 3 1 0 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EFC39758.1 - 0.014 15.9 12.3 5.3 8.0 0.1 5.5 4 1 0 4 4 4 0 Leucine Rich Repeat Stn1_C PF12659.7 EFC39758.1 - 0.19 11.7 0.8 22 5.0 0.1 3.0 3 1 0 3 3 3 0 Telomere capping C-terminal wHTH Tup_N PF08581.10 EFC39759.1 - 0.00038 20.7 11.1 0.00038 20.7 11.1 5.1 2 1 3 5 5 5 2 Tup N-terminal Cnn_1N PF07989.11 EFC39759.1 - 0.0059 16.7 44.8 0.038 14.1 4.9 4.8 2 2 3 5 5 5 3 Centrosomin N-terminal motif 1 Vip3A_N PF12495.8 EFC39759.1 - 0.27 11.1 20.0 1.2 9.0 11.0 2.8 1 1 0 2 2 2 0 Vegetative insecticide protein 3A N terminal CENP-F_leu_zip PF10473.9 EFC39759.1 - 3.8 7.5 53.5 0.59 10.1 6.2 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UPF0242 PF06785.11 EFC39759.1 - 9.9 6.2 51.9 3.7 7.6 14.0 3.1 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF547 PF04784.14 EFC39760.1 - 3e-25 88.6 0.1 7.8e-25 87.3 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF547 QIL1 PF15884.5 EFC39760.1 - 0.061 13.9 0.1 0.29 11.7 0.1 2.2 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 RGS PF00615.19 EFC39760.1 - 0.081 13.2 16.6 0.047 14.0 10.1 3.7 3 1 0 3 3 3 0 Regulator of G protein signaling domain DUF285 PF03382.14 EFC39760.1 - 0.23 11.2 8.6 2.2 8.1 8.2 2.5 1 1 1 2 2 2 0 Mycoplasma protein of unknown function, DUF285 LuxT_C PF18285.1 EFC39760.1 - 0.53 10.9 5.1 1.4 9.5 0.0 3.3 2 1 2 4 4 4 0 Tetracycline repressor LuxT C-terminal domain Tubulin PF00091.25 EFC39761.1 - 6.5e-70 235.4 0.0 1.2e-69 234.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC39761.1 - 3.6e-41 140.3 0.1 5.5e-41 139.7 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC39761.1 - 3.6e-05 24.1 0.0 9.8e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EFC39761.1 - 0.00063 19.0 0.0 0.0029 16.9 0.0 1.9 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 EFC39761.1 - 0.0011 18.6 0.0 0.0022 17.7 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain RGS PF00615.19 EFC39762.1 - 4.3e-16 59.2 1.3 1.4e-15 57.6 1.3 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain Serpin PF00079.20 EFC39763.1 - 4.3e-78 263.2 10.7 5.5e-78 262.9 10.7 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DHHA1 PF02272.19 EFC39763.1 - 1.9 8.9 5.0 3.5 8.0 1.3 2.6 2 1 0 2 2 2 0 DHHA1 domain Pkinase PF00069.25 EFC39765.1 - 5e-55 186.7 7.0 7.9e-55 186.0 7.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39765.1 - 2.6e-32 112.1 1.9 3.9e-32 111.6 1.9 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC39765.1 - 5.2e-16 57.8 5.6 0.00026 20.9 0.0 7.6 8 0 0 8 8 7 4 NHL repeat Pkinase_fungal PF17667.1 EFC39765.1 - 5.1e-07 28.8 0.1 8.6e-07 28.1 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFC39765.1 - 0.0044 16.6 1.3 0.011 15.3 1.3 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.22 EFC39765.1 - 0.0055 16.3 2.3 0.013 15.1 2.3 1.6 1 0 0 1 1 1 1 RIO1 family ComR_TPR PF18710.1 EFC39765.1 - 0.0072 15.9 5.4 0.022 14.3 5.4 1.8 1 0 0 1 1 1 1 ComR tetratricopeptide EGF_2 PF07974.13 EFC39765.1 - 0.0078 16.6 7.5 0.017 15.5 7.5 1.6 1 0 0 1 1 1 1 EGF-like domain Kinase-like PF14531.6 EFC39765.1 - 0.071 12.4 0.3 0.12 11.7 0.3 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 EFC39765.1 - 0.072 12.4 0.8 0.13 11.6 0.8 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family EGF PF00008.27 EFC39765.1 - 0.28 11.5 3.9 0.82 10.0 3.9 1.8 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 EFC39765.1 - 3.8 8.3 5.8 10 7.0 5.8 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF LRR_4 PF12799.7 EFC39766.1 - 0.022 15.2 2.8 7.8 7.1 0.0 4.5 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) CHZ PF09649.10 EFC39767.1 - 0.00011 21.5 0.1 0.00031 20.1 0.1 1.8 1 0 0 1 1 1 1 Histone chaperone domain CHZ Pkinase PF00069.25 EFC39768.1 - 6.8e-54 183.0 1.0 1.1e-53 182.3 1.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39768.1 - 8.2e-31 107.2 0.3 1.2e-30 106.6 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC39768.1 - 5.9e-07 28.6 0.1 1.1e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EFC39768.1 - 0.003 17.5 2.2 0.006 16.5 2.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family DUF3377 PF11857.8 EFC39768.1 - 0.011 15.6 3.6 0.029 14.3 3.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) EGF_2 PF07974.13 EFC39768.1 - 0.033 14.5 21.6 0.82 10.1 8.7 2.7 2 0 0 2 2 2 0 EGF-like domain Kdo PF06293.14 EFC39768.1 - 0.061 12.7 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NHL PF01436.21 EFC39768.1 - 0.063 13.3 7.6 11 6.3 0.0 5.6 7 0 0 7 7 7 0 NHL repeat DUF5074 PF16819.5 EFC39768.1 - 0.087 12.9 3.8 7.2 6.7 0.0 4.8 4 2 1 5 5 5 0 Domain of unknown function (DUF5074) Tmemb_9 PF05434.11 EFC39768.1 - 0.087 12.7 0.8 0.19 11.6 0.8 1.5 1 0 0 1 1 1 0 TMEM9 YrbL-PhoP_reg PF10707.9 EFC39768.1 - 0.091 12.3 0.1 0.26 10.8 0.1 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ECSCR PF15820.5 EFC39768.1 - 0.16 11.8 6.1 0.11 12.3 3.2 2.1 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator ASFV_J13L PF05568.11 EFC39768.1 - 0.58 9.9 3.1 1.1 9.0 3.1 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF4389 PF14333.6 EFC39768.1 - 1.8 8.5 4.3 4.5 7.3 4.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) NHL PF01436.21 EFC39769.1 - 6.4e-14 51.2 1.2 5.6e-05 23.0 0.0 3.5 3 0 0 3 3 3 3 NHL repeat G8 PF10162.9 EFC39770.1 - 1.5e-20 73.5 0.1 3.9e-20 72.2 0.1 1.7 1 0 0 1 1 1 1 G8 domain NosD PF05048.13 EFC39770.1 - 0.0047 16.2 10.5 0.0081 15.5 0.5 4.0 4 0 0 4 4 4 2 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 EFC39770.1 - 0.0052 16.7 7.9 0.0052 16.7 7.9 4.5 4 2 0 4 4 4 2 Right handed beta helix region CHRD PF07452.12 EFC39770.1 - 0.027 15.5 0.0 0.076 14.0 0.0 1.8 1 0 0 1 1 1 0 CHRD domain SIR2 PF02146.17 EFC39772.1 - 6.1e-52 176.1 0.0 8.3e-52 175.7 0.0 1.2 1 0 0 1 1 1 1 Sir2 family Desulfoferrod_N PF06397.12 EFC39772.1 - 0.0027 17.3 1.1 0.0027 17.3 1.1 1.8 2 0 0 2 2 2 1 Desulfoferrodoxin, N-terminal domain PHD_4 PF16866.5 EFC39772.1 - 0.14 12.3 3.0 0.34 11.0 3.0 1.7 1 0 0 1 1 1 0 PHD-finger XPA_N PF01286.18 EFC39772.1 - 0.48 10.5 3.1 0.42 10.7 0.3 2.2 2 0 0 2 2 2 0 XPA protein N-terminal PIGA PF08288.12 EFC39773.1 - 0.069 13.7 0.1 0.15 12.6 0.1 1.5 1 0 0 1 1 1 0 PIGA (GPI anchor biosynthesis) Duffy_binding PF05424.11 EFC39774.1 - 0.081 13.0 2.8 0.22 11.6 2.8 1.7 1 0 0 1 1 1 0 Duffy binding domain RGS PF00615.19 EFC39775.1 - 9.8e-12 45.2 2.8 9.8e-12 45.2 2.8 2.7 3 0 0 3 3 3 1 Regulator of G protein signaling domain Abhydrolase_1 PF00561.20 EFC39776.1 - 3e-14 53.3 0.0 5.3e-13 49.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC39776.1 - 5.7e-13 48.7 0.0 2.6e-12 46.5 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC39776.1 - 2.3e-06 28.4 0.0 3.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 EFC39776.1 - 0.0024 17.5 0.0 0.078 12.5 0.0 2.4 2 0 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 EFC39776.1 - 0.019 14.4 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family BAAT_C PF08840.11 EFC39776.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Chlorophyllase2 PF12740.7 EFC39776.1 - 0.15 11.0 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme RINGv PF12906.7 EFC39777.1 - 3.5e-11 43.1 7.3 7.2e-11 42.0 7.3 1.6 1 0 0 1 1 1 1 RING-variant domain Hist_deacetyl PF00850.19 EFC39778.1 - 1.1e-31 110.5 0.1 6.6e-31 107.9 0.1 2.2 1 1 0 1 1 1 1 Histone deacetylase domain NIL PF09383.10 EFC39778.1 - 0.13 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 NIL domain RCC1_2 PF13540.6 EFC39779.1 - 0.0035 17.1 1.9 0.078 12.8 0.0 3.6 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Imm45 PF15572.6 EFC39779.1 - 0.096 13.1 0.6 1.1 9.7 0.2 2.6 1 1 1 2 2 2 0 Immunity protein 45 Tyr-DNA_phospho PF06087.12 EFC39779.1 - 0.11 11.3 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase F_actin_bund_C PF18060.1 EFC39781.1 - 1.7e-30 105.0 20.1 1.7e-30 105.0 20.1 2.1 2 0 0 2 2 2 1 F actin bundling C terminal DUF4407 PF14362.6 EFC39781.1 - 8 5.7 9.3 9.9 5.4 7.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) EamA PF00892.20 EFC39783.1 - 1.3e-07 31.9 15.5 1.3e-07 31.9 15.5 3.6 1 1 2 3 3 3 1 EamA-like transporter family VWA PF00092.28 EFC39784.1 - 1e-17 64.9 0.0 4.1e-17 63.0 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC39784.1 - 9e-11 42.4 0.0 2.9e-10 40.7 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC39784.1 - 1.9e-05 24.7 0.0 0.00018 21.5 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain Arrestin_C PF02752.22 EFC39784.1 - 0.028 14.9 0.2 0.082 13.4 0.2 1.7 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain DUF1013 PF06242.11 EFC39784.1 - 0.043 13.9 1.2 0.045 13.8 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1013) Ocnus PF05005.15 EFC39784.1 - 0.056 13.6 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) MOZART1 PF12554.8 EFC39784.1 - 0.059 13.2 0.2 3.5 7.5 0.0 2.9 3 0 0 3 3 3 0 Mitotic-spindle organizing gamma-tubulin ring associated ASH PF15780.5 EFC39784.1 - 0.073 13.3 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin ChiC PF06483.11 EFC39784.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Chitinase C RsgA_GTPase PF03193.16 EFC39784.1 - 0.12 12.3 0.3 3.6 7.5 0.1 2.6 2 0 0 2 2 2 0 RsgA GTPase Sacchrp_dh_NADP PF03435.18 EFC39785.1 - 4.5e-16 59.3 0.0 7.9e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EFC39785.1 - 1.8e-09 37.1 0.0 2.8e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EFC39785.1 - 0.00018 21.4 0.0 0.00029 20.8 0.0 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EFC39785.1 - 0.0033 16.5 0.0 0.0051 15.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC39785.1 - 0.0099 15.4 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 EFC39785.1 - 0.032 14.3 0.0 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 EFC39785.1 - 0.1 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase LRR_6 PF13516.6 EFC39786.1 - 3e-34 114.2 24.1 1.7e-05 24.5 0.0 11.4 11 1 0 11 11 11 9 Leucine Rich repeat LRR_8 PF13855.6 EFC39786.1 - 4.9e-25 87.1 21.1 6.3e-08 32.3 0.3 5.6 2 2 4 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC39786.1 - 1e-15 57.6 43.2 0.0012 19.2 1.8 8.5 3 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39786.1 - 1e-06 28.4 17.5 20 6.2 0.0 10.2 12 0 0 12 12 12 0 Leucine Rich Repeat DUF4347 PF14252.6 EFC39786.1 - 0.00078 19.3 0.3 0.58 10.0 0.1 4.3 2 2 3 5 5 5 1 Domain of unknown function (DUF4347) Mannitol_dh PF01232.23 EFC39786.1 - 0.057 13.6 0.4 4.9 7.3 0.0 2.8 1 1 2 3 3 3 0 Mannitol dehydrogenase Rossmann domain F-box-like PF12937.7 EFC39786.1 - 0.092 12.7 0.1 0.24 11.3 0.0 1.7 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 EFC39786.1 - 0.14 12.0 0.5 0.38 10.7 0.2 1.9 2 0 0 2 2 2 0 F-box domain VirE_N PF08800.10 EFC39786.1 - 0.16 12.1 0.0 9.2 6.4 0.0 2.3 2 0 0 2 2 2 0 VirE N-terminal domain Zn_clus PF00172.18 EFC39787.1 - 8.2e-09 35.4 13.6 8.2e-09 35.4 13.6 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 EFC39788.1 - 2.7e-10 40.0 0.0 5.3e-10 39.0 0.0 1.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC39788.1 - 6.4e-05 22.7 0.3 0.00052 19.8 0.0 2.5 2 1 0 2 2 2 1 F-box domain F-box_5 PF18511.1 EFC39788.1 - 0.11 12.1 0.0 0.64 9.6 0.0 2.4 2 1 0 2 2 2 0 F-box Arm PF00514.23 EFC39789.1 - 2.9e-36 122.4 8.1 4.5e-06 26.5 0.2 9.1 9 0 0 9 9 9 7 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC39789.1 - 7.7e-09 35.9 0.1 0.072 13.6 0.0 5.2 4 2 1 5 5 5 3 HEAT-like repeat RICTOR_V PF14668.6 EFC39789.1 - 0.00024 21.3 2.2 5.3 7.4 0.0 5.7 6 1 1 7 7 7 1 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 EFC39789.1 - 0.002 18.1 0.2 1 9.4 0.0 3.1 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain Phage_NinH PF06322.11 EFC39789.1 - 0.14 12.1 0.0 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Phage NinH protein DUF4868 PF16162.5 EFC39789.1 - 0.22 11.4 0.2 0.22 11.4 0.2 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4868) Nucleotid_trans PF03407.16 EFC39790.1 - 1.4e-19 70.9 0.6 6.1e-19 68.8 0.6 1.8 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_transf_8 PF01501.20 EFC39790.1 - 0.0077 15.8 0.6 0.011 15.3 0.6 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF3695 PF12494.8 EFC39790.1 - 0.057 13.3 0.2 0.76 9.7 0.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3695) DUF5395 PF17373.2 EFC39790.1 - 0.081 13.6 0.4 16 6.2 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5395) Kelch_3 PF13415.6 EFC39791.1 - 4.6e-41 138.4 1.7 5.2e-08 33.0 0.1 6.7 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC39791.1 - 8.2e-36 121.4 12.3 2.9e-08 33.5 0.4 7.1 7 0 0 7 7 7 6 Kelch motif Kelch_1 PF01344.25 EFC39791.1 - 7.6e-34 115.0 6.4 8.1e-09 34.9 0.3 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFC39791.1 - 1.1e-33 115.0 5.7 2.8e-08 33.6 0.3 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC39791.1 - 1.5e-31 107.6 9.9 5.5e-08 32.8 0.2 6.3 6 0 0 6 6 6 5 Kelch motif BTB PF00651.31 EFC39791.1 - 1.4e-30 105.8 0.6 1.2e-19 70.5 0.2 3.9 2 2 1 3 3 3 3 BTB/POZ domain Kelch_2 PF07646.15 EFC39791.1 - 2.3e-24 84.4 3.6 5.8e-05 22.9 0.1 6.8 6 0 0 6 6 6 6 Kelch motif BTB_3 PF16017.5 EFC39791.1 - 0.00026 21.0 0.3 1.8 8.7 0.0 3.3 3 0 0 3 3 3 2 BTB/POZ domain RAG2 PF03089.14 EFC39791.1 - 0.00068 18.7 0.1 0.0038 16.3 0.0 2.2 1 1 1 2 2 2 1 Recombination activating protein 2 BACK PF07707.15 EFC39791.1 - 0.001 19.1 0.3 0.071 13.2 0.1 2.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Glycos_transf_1 PF00534.20 EFC39792.1 - 2.2e-11 43.6 0.0 1.8e-10 40.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFC39792.1 - 3.6e-10 40.4 0.0 8.6e-10 39.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFC39792.1 - 0.0011 19.4 0.0 0.0024 18.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFC39792.1 - 0.015 15.3 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase Family 4 INCENP_ARK-bind PF03941.15 EFC39792.1 - 0.17 11.9 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region Arm PF00514.23 EFC39793.1 - 4e-08 33.0 12.3 0.0014 18.6 0.0 6.9 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat SIL1 PF16782.5 EFC39793.1 - 0.0004 19.7 2.0 0.033 13.4 0.0 2.7 2 1 1 3 3 3 2 Nucleotide exchange factor SIL1 CK2S PF15011.6 EFC39793.1 - 0.0035 17.2 2.1 8 6.3 0.0 3.4 3 0 0 3 3 3 2 Casein Kinase 2 substrate DUF3361 PF11841.8 EFC39793.1 - 0.021 14.8 7.4 0.039 13.9 0.6 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) DUF5578 PF17741.1 EFC39793.1 - 0.063 12.7 6.8 0.077 12.4 1.0 3.4 3 1 0 3 3 3 0 Family of unknown function (DUF5578) RTP1_C1 PF10363.9 EFC39793.1 - 0.14 12.4 2.1 2.8 8.1 0.3 3.2 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 REV1_C PF16727.5 EFC39793.1 - 0.6 10.5 2.1 2.1 8.8 0.1 2.8 3 0 0 3 3 3 0 DNA repair protein REV1 C-terminal domain SYCP2_ARLD PF18581.1 EFC39793.1 - 0.6 10.1 11.8 0.26 11.3 3.5 3.1 2 1 1 3 3 3 0 Synaptonemal complex 2 armadillo-repeat-like domain Reticulon PF02453.17 EFC39794.1 - 2.1e-32 112.3 8.9 2.7e-32 111.9 8.9 1.1 1 0 0 1 1 1 1 Reticulon Bombolitin PF08096.11 EFC39794.1 - 0.86 10.0 3.7 5.7 7.4 0.8 3.0 3 0 0 3 3 3 0 Bombolitin family BCS1_N PF08740.11 EFC39795.1 - 7.1e-36 123.9 0.0 1e-35 123.4 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EFC39795.1 - 4.9e-15 56.1 0.0 1.6e-13 51.2 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC39795.1 - 0.00022 21.6 0.0 0.00044 20.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFC39795.1 - 0.0018 18.3 0.0 0.0036 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_6 PF12774.7 EFC39795.1 - 0.002 17.1 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DUF815 PF05673.13 EFC39795.1 - 0.0024 17.1 0.0 0.004 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 EFC39795.1 - 0.0049 16.7 0.0 0.008 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC39795.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC39795.1 - 0.017 14.6 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 EFC39795.1 - 0.046 14.1 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 EFC39795.1 - 0.046 14.2 0.0 0.39 11.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter RuvB_N PF05496.12 EFC39795.1 - 0.051 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC39795.1 - 0.062 13.6 0.0 0.18 12.1 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 EFC39795.1 - 0.075 13.6 0.0 0.25 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EFC39795.1 - 0.093 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 KaiC AAA_28 PF13521.6 EFC39795.1 - 0.11 12.7 0.1 0.23 11.7 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFC39795.1 - 0.21 11.3 0.0 0.35 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pentapeptide PF00805.22 EFC39796.1 - 7.2e-38 127.8 46.3 4e-10 39.1 4.3 6.8 6 1 1 7 7 7 5 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC39796.1 - 2.3e-28 98.2 43.2 1.3e-12 47.7 1.2 5.5 2 1 4 6 6 6 5 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC39796.1 - 1.5e-13 50.6 34.7 3.9e-07 30.1 0.9 5.6 5 2 2 7 7 7 4 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC39796.1 - 1.8e-05 25.0 0.2 0.00017 21.9 0.0 2.6 2 0 0 2 2 2 1 BTB/POZ domain RGS PF00615.19 EFC39796.1 - 0.0024 18.1 0.7 0.0024 18.1 0.7 3.2 3 0 0 3 3 3 1 Regulator of G protein signaling domain Prefoldin PF02996.17 EFC39796.1 - 7.8 6.4 9.9 0.1 12.5 0.5 2.7 4 0 0 4 4 4 0 Prefoldin subunit RCC1_2 PF13540.6 EFC39797.1 - 0.0009 19.0 0.2 0.0027 17.5 0.2 1.9 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC39797.1 - 0.0021 18.6 0.1 0.09 13.4 0.0 3.2 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Abhydrolase_3 PF07859.13 EFC39798.1 - 8.8e-13 48.6 0.1 3.8e-12 46.5 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC39798.1 - 1.9e-10 40.2 0.0 2e-09 36.8 0.0 2.1 1 1 0 1 1 1 1 Steryl acetyl hydrolase DUF2235 PF09994.9 EFC39798.1 - 0.00032 20.1 0.0 0.00056 19.4 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Lipase_3 PF01764.25 EFC39798.1 - 0.0051 16.7 0.0 0.02 14.8 0.0 2.0 1 0 0 1 1 1 1 Lipase (class 3) Peptidase_S9 PF00326.21 EFC39798.1 - 0.014 14.9 0.1 0.032 13.7 0.1 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFC39798.1 - 0.024 13.9 0.0 0.072 12.4 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF3089 PF11288.8 EFC39798.1 - 0.048 13.2 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) UPF0227 PF05728.12 EFC39798.1 - 0.05 13.6 0.0 6.4 6.7 0.0 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0227) F-box PF00646.33 EFC39799.1 - 2.7e-05 23.9 1.5 8.9e-05 22.3 1.5 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC39799.1 - 0.0039 17.0 0.6 0.0086 16.0 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFC39799.1 - 0.023 14.6 1.0 0.053 13.4 1.0 1.6 1 0 0 1 1 1 0 F-box adh_short PF00106.25 EFC39801.1 - 5.3e-37 127.2 0.0 8.3e-37 126.6 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39801.1 - 1.3e-17 64.1 0.0 1.7e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39801.1 - 1.7e-10 41.1 0.0 2.8e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC39801.1 - 0.0019 17.4 0.1 0.003 16.7 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein EF-hand_1 PF00036.32 EFC39803.1 - 1.3e-09 36.9 1.2 1.1e-05 24.6 0.1 3.9 3 1 1 4 4 4 2 EF hand EF-hand_7 PF13499.6 EFC39803.1 - 6.3e-09 36.2 5.1 9.7e-09 35.6 1.7 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC39803.1 - 2.4e-08 33.2 10.2 7.2e-06 25.5 0.2 4.1 2 1 2 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EFC39803.1 - 1.9e-05 23.9 7.3 0.0031 16.9 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC39803.1 - 0.019 14.8 2.7 0.019 14.8 2.7 2.8 2 1 1 3 3 3 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC39803.1 - 0.13 12.6 0.2 2.2 8.7 0.2 2.3 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Grp7_allergen PF16984.5 EFC39803.1 - 0.14 12.2 0.0 0.49 10.4 0.0 1.7 2 0 0 2 2 2 0 Group 7 allergen DUF3467 PF11950.8 EFC39804.1 - 0.0028 17.8 0.3 0.021 15.0 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3467) RNA_pol_Rpb4 PF03874.16 EFC39804.1 - 0.011 16.1 1.3 0.011 16.1 1.3 5.3 6 0 0 6 6 6 0 RNA polymerase Rpb4 TPR_2 PF07719.17 EFC39804.1 - 0.064 13.4 0.0 0.63 10.3 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Methyltransf_14 PF08484.11 EFC39804.1 - 0.074 12.9 0.2 0.35 10.7 0.0 2.2 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain DUF1858 PF08984.11 EFC39804.1 - 0.12 12.6 1.1 5.3 7.3 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1858) YnfE PF17452.2 EFC39804.1 - 0.52 10.6 5.5 2.9 8.2 0.0 4.7 6 0 0 6 6 6 0 Uncharacterized YnfE-like TM2 PF05154.16 EFC39805.1 - 1.4e-10 41.3 14.2 3.2e-10 40.2 14.2 1.5 1 0 0 1 1 1 1 TM2 domain PPR_2 PF13041.6 EFC39805.1 - 4.5e-07 29.9 0.1 1.5e-06 28.3 0.1 2.0 1 0 0 1 1 1 1 PPR repeat family PPR_3 PF13812.6 EFC39805.1 - 0.00019 21.5 0.1 0.0013 18.8 0.0 2.5 2 0 0 2 2 2 1 Pentatricopeptide repeat domain LMP PF04778.12 EFC39805.1 - 0.0011 18.9 13.0 0.0011 18.9 13.0 6.1 4 2 1 6 6 6 1 LMP repeated region PPR PF01535.20 EFC39805.1 - 0.2 12.0 0.8 3.9 7.9 0.1 3.3 3 0 0 3 3 3 0 PPR repeat KI67R PF08065.12 EFC39805.1 - 9.9 6.8 11.6 2.2 8.8 6.0 3.0 3 0 0 3 3 3 0 KI67R (NUC007) repeat Actin PF00022.19 EFC39806.1 - 7.8e-72 242.1 0.0 4e-71 239.8 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC39806.1 - 2.8e-06 26.4 0.0 0.00083 18.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein PilM_2 PF11104.8 EFC39806.1 - 0.12 11.4 0.0 0.32 10.0 0.0 1.7 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Glyco_hydro_15 PF00723.21 EFC39807.1 - 1.7e-46 158.9 0.0 5e-46 157.4 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 TLD PF07534.16 EFC39808.1 - 1.4e-11 44.7 0.9 2.8e-11 43.8 0.9 1.5 1 1 0 1 1 1 1 TLD RRM_1 PF00076.22 EFC39809.1 - 3e-07 30.1 0.3 4.7e-07 29.5 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC39809.1 - 0.019 14.8 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFC39809.1 - 0.097 12.7 0.1 0.2 11.7 0.1 1.5 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif TP6A_N PF04406.14 EFC39811.1 - 5.4e-13 48.7 0.8 1.4e-12 47.4 0.5 1.9 2 0 0 2 2 2 1 Type IIB DNA topoisomerase DUF775 PF05603.12 EFC39812.1 - 6.9e-40 136.7 0.5 9e-40 136.3 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF775) P22_AR_N PF10547.9 EFC39812.1 - 0.056 13.8 0.1 0.094 13.1 0.1 1.3 1 0 0 1 1 1 0 P22_AR N-terminal domain ASF1_hist_chap PF04729.13 EFC39813.1 - 4.4e-05 23.5 0.7 5.5e-05 23.2 0.7 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone PRP3 PF08572.10 EFC39814.1 - 9.8e-43 146.5 19.9 9.8e-43 146.5 19.9 2.5 2 1 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 EFC39814.1 - 6.3e-26 91.2 0.0 6.3e-26 91.2 0.0 4.1 4 1 0 4 4 4 1 Protein of unknown function (DUF1115) TPR_MLP1_2 PF07926.12 EFC39815.1 - 0.0016 18.5 13.9 0.0016 18.5 13.9 4.1 4 1 1 5 5 5 1 TPR/MLP1/MLP2-like protein YvfG PF09628.10 EFC39815.1 - 0.058 13.8 0.2 1.7 9.1 0.0 3.1 2 0 0 2 2 2 0 YvfG protein PilJ PF13675.6 EFC39815.1 - 0.14 12.1 6.8 4 7.5 1.5 3.0 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term HOOK PF05622.12 EFC39815.1 - 2.8 6.0 50.6 0.59 8.2 9.9 3.5 2 1 1 3 3 3 0 HOOK protein RGS PF00615.19 EFC39816.1 - 4e-14 52.9 3.5 4e-14 52.9 3.5 3.3 3 0 0 3 3 3 2 Regulator of G protein signaling domain SLX9 PF15341.6 EFC39816.1 - 3.1e-11 43.8 22.1 3.1e-11 43.8 22.1 4.8 4 1 0 4 4 4 1 Ribosome biogenesis protein SLX9 Androgen_recep PF02166.16 EFC39816.1 - 0.21 10.4 7.0 0.39 9.5 7.0 1.4 1 0 0 1 1 1 0 Androgen receptor SHIPPO-rpt PF07004.12 EFC39817.1 - 1.8e-13 50.7 54.4 0.05 14.5 0.5 10.7 9 2 1 10 10 10 9 Sperm-tail PG-rich repeat HMMR_N PF15905.5 EFC39817.1 - 9.1 5.6 10.7 4.3 6.7 0.9 3.4 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal Pirin PF02678.16 EFC39818.1 - 6.5e-29 100.1 0.1 1.5e-28 98.9 0.0 1.7 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 EFC39818.1 - 2.2e-24 85.8 0.2 1e-23 83.6 0.2 2.0 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Pkinase PF00069.25 EFC39819.1 - 1.1e-11 44.7 0.0 2e-11 43.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 EFC39819.1 - 6.3e-07 29.9 0.0 0.00067 20.2 0.0 4.1 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Pkinase_Tyr PF07714.17 EFC39819.1 - 2.7e-05 23.6 0.0 4.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RCC1_2 PF13540.6 EFC39819.1 - 0.00027 20.7 2.8 1.1 9.1 0.1 4.5 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat EF-hand_1 PF00036.32 EFC39820.1 - 6.7e-21 72.2 9.9 4.9e-07 28.8 0.5 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFC39820.1 - 4e-20 72.0 17.1 1.7e-11 44.4 3.2 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFC39820.1 - 4.2e-18 64.9 10.2 2.4e-06 27.3 0.5 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC39820.1 - 1.4e-17 62.0 12.0 1e-05 25.1 0.5 3.7 3 1 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 EFC39820.1 - 4.5e-16 57.5 6.9 4.8e-05 22.7 0.2 3.3 3 0 0 3 3 3 3 EF hand EF-hand_4 PF12763.7 EFC39820.1 - 4.1e-07 29.9 12.7 0.0019 18.1 0.8 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC39820.1 - 0.001 19.3 9.2 0.0058 16.9 6.4 2.7 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region PolC_DP2 PF03833.13 EFC39820.1 - 0.011 13.6 0.7 0.013 13.4 0.7 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Vps23_core PF09454.10 EFC39820.1 - 0.043 13.8 0.2 1 9.4 0.0 2.8 3 0 0 3 3 3 0 Vps23 core domain EF-hand_9 PF14658.6 EFC39820.1 - 0.1 13.0 0.2 14 6.1 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain Caleosin PF05042.13 EFC39820.1 - 0.24 11.3 7.5 3.7 7.4 0.3 2.9 2 1 0 3 3 3 0 Caleosin related protein DUF4061 PF13270.6 EFC39821.1 - 0.015 15.6 2.8 0.015 15.6 2.8 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4061) KxDL PF10241.9 EFC39821.1 - 0.025 14.8 3.0 0.025 14.8 3.0 3.7 1 1 2 4 4 4 0 Uncharacterized conserved protein IL2 PF00715.17 EFC39821.1 - 2.5 8.0 15.8 1.4 8.9 5.6 2.5 1 1 1 2 2 2 0 Interleukin 2 PC4 PF02229.16 EFC39822.1 - 8e-15 54.2 1.1 2.9e-14 52.4 1.2 1.9 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) DEK_C PF08766.11 EFC39822.1 - 4.5e-13 48.9 5.4 1e-12 47.8 5.4 1.6 1 0 0 1 1 1 1 DEK C terminal domain Cytochrom_C1 PF02167.15 EFC39822.1 - 0.028 14.2 0.5 0.032 13.9 0.5 1.1 1 0 0 1 1 1 0 Cytochrome C1 family MPM1 PF17234.2 EFC39822.1 - 0.039 14.2 12.1 0.052 13.8 12.1 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 PI3K_1B_p101 PF10486.9 EFC39822.1 - 0.058 11.2 5.9 0.058 11.2 5.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MID_MedPIWI PF18296.1 EFC39822.1 - 0.11 12.3 3.4 0.11 12.3 3.4 1.1 1 0 0 1 1 1 0 MID domain of medPIWI DUF3323 PF11796.8 EFC39822.1 - 0.13 12.2 0.2 0.16 11.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) Peptidase_S24 PF00717.23 EFC39822.1 - 0.14 12.2 1.4 0.21 11.6 0.4 1.8 2 0 0 2 2 2 0 Peptidase S24-like AIF_C PF14721.6 EFC39822.1 - 0.21 12.0 4.4 0.26 11.6 4.4 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RP-C_C PF11800.8 EFC39822.1 - 0.22 11.6 2.5 0.24 11.5 2.5 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region CDC45 PF02724.14 EFC39822.1 - 0.3 9.3 10.3 0.31 9.3 10.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 EFC39822.1 - 1.3 8.1 3.1 1.3 8.2 3.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EFC39822.1 - 1.3 7.7 4.6 1.3 7.7 4.6 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 EFC39822.1 - 1.6 7.5 9.3 1.7 7.4 9.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3298 PF11738.8 EFC39822.1 - 3.4 8.8 5.4 8.4 7.5 5.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3298) DUF4530 PF15039.6 EFC39822.1 - 6.6 6.9 8.8 21 5.3 8.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4530) NAD_binding_1 PF00175.21 EFC39823.1 - 2.8e-25 89.1 0.0 4.3e-25 88.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFC39823.1 - 2.9e-23 82.1 0.0 7e-23 80.9 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFC39823.1 - 4.7e-07 30.0 0.0 1.1e-05 25.6 0.0 2.1 1 1 1 2 2 2 1 Ferric reductase NAD binding domain LCAT PF02450.15 EFC39824.1 - 7.4e-06 25.4 0.1 2.1e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EFC39824.1 - 0.00076 19.1 0.1 0.025 14.1 0.0 2.4 1 1 0 2 2 2 1 Putative serine esterase (DUF676) DUF1749 PF08538.10 EFC39824.1 - 0.0037 16.4 0.0 0.0091 15.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) DUF2974 PF11187.8 EFC39824.1 - 0.0059 16.2 0.0 0.018 14.6 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PGAP1 PF07819.13 EFC39824.1 - 0.015 15.1 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Nop PF01798.18 EFC39824.1 - 0.055 12.9 3.2 0.14 11.6 3.2 1.6 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin Abhydrolase_1 PF00561.20 EFC39824.1 - 0.089 12.4 0.0 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold partial_CstF PF15861.5 EFC39824.1 - 0.53 10.1 4.9 0.22 11.3 1.1 2.2 2 0 0 2 2 2 0 Partial cleavage stimulation factor domain RMI1_N PF08585.12 EFC39824.1 - 0.76 9.5 8.1 0.35 10.6 5.0 2.0 2 0 0 2 2 2 0 RecQ mediated genome instability protein RP-C_C PF11800.8 EFC39824.1 - 3.7 7.6 5.7 7 6.7 5.7 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4820 PF16091.5 EFC39824.1 - 7.7 5.8 7.3 14 4.9 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Pkinase PF00069.25 EFC39825.1 - 1.2e-28 100.2 2.7 1.2e-28 100.2 2.7 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39825.1 - 2e-20 73.2 0.8 3.4e-20 72.4 0.8 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4116 PF13475.6 EFC39825.1 - 7.1e-06 25.6 0.3 7.1e-06 25.6 0.3 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF4116) RIO1 PF01163.22 EFC39825.1 - 0.0045 16.6 0.4 0.0045 16.6 0.4 2.1 2 0 0 2 2 2 1 RIO1 family Telomere_reg-2 PF10193.9 EFC39825.1 - 0.019 15.4 1.3 0.28 11.6 0.2 2.8 2 0 0 2 2 2 0 Telomere length regulation protein Kinase-like PF14531.6 EFC39825.1 - 0.046 13.0 0.0 0.076 12.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Mg_trans_NIPA PF05653.14 EFC39827.1 - 5.7e-12 45.4 29.6 7.1e-12 45.0 29.6 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA CAF1A PF12253.8 EFC39827.1 - 0.41 10.9 3.9 0.7 10.1 3.9 1.3 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A EamA PF00892.20 EFC39828.1 - 9.7e-08 32.3 44.2 0.00039 20.6 5.6 3.2 3 0 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 EFC39828.1 - 2.1e-07 30.5 6.9 2.1e-07 30.5 6.9 2.3 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport Sugar_transport PF06800.12 EFC39828.1 - 0.00092 18.6 20.0 0.0019 17.6 4.4 3.3 3 0 0 3 3 3 3 Sugar transport protein Orf78 PF06024.12 EFC39828.1 - 0.059 13.7 1.6 0.26 11.6 0.3 2.7 2 0 0 2 2 2 0 Orf78 (ac78) Neurensin PF14927.6 EFC39828.1 - 0.33 10.7 0.0 0.33 10.7 0.0 2.3 2 1 0 2 2 2 0 Neurensin PhoD PF09423.10 EFC39829.1 - 8.7e-16 57.9 2.9 5.6e-15 55.2 2.9 1.9 1 1 0 1 1 1 1 PhoD-like phosphatase C2 PF00168.30 EFC39829.1 - 6.3e-15 55.3 0.2 2e-12 47.3 0.2 2.7 1 1 0 1 1 1 1 C2 domain 2OG-FeII_Oxy_3 PF13640.6 EFC39829.1 - 8.2e-07 29.8 0.0 2.4e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EFC39829.1 - 0.0021 17.9 0.1 0.0062 16.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like Actin PF00022.19 EFC39829.1 - 0.025 13.2 0.0 2.2 6.8 0.0 2.2 1 1 1 2 2 2 0 Actin F-box PF00646.33 EFC39829.1 - 0.086 12.8 0.1 0.31 11.0 0.1 2.1 1 0 0 1 1 1 0 F-box domain PepSY_like PF11396.8 EFC39830.1 - 0.031 14.8 1.9 8.1 7.1 0.0 3.6 2 1 1 3 3 3 0 Putative beta-lactamase-inhibitor-like, PepSY-like ABC_membrane PF00664.23 EFC39831.1 - 7.6e-51 173.4 40.8 2.7e-31 109.2 19.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFC39831.1 - 9.8e-48 162.2 0.7 3.9e-27 95.4 0.1 2.8 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 EFC39831.1 - 2.6e-06 27.4 0.3 0.0012 18.8 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 EFC39831.1 - 3.5e-06 27.3 0.6 0.11 12.5 0.0 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_29 PF13555.6 EFC39831.1 - 1.4e-05 24.7 5.2 0.023 14.4 0.8 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFC39831.1 - 3.4e-05 23.9 3.0 0.14 12.2 0.1 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 EFC39831.1 - 9.4e-05 21.6 0.1 0.025 13.6 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Dynamin_N PF00350.23 EFC39831.1 - 0.00022 21.3 1.4 0.13 12.4 0.0 3.1 2 0 0 2 2 2 1 Dynamin family SMC_N PF02463.19 EFC39831.1 - 0.00024 20.6 13.2 0.0038 16.7 0.1 3.7 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFC39831.1 - 0.0015 18.8 0.3 2.9 8.1 0.2 2.8 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 EFC39831.1 - 0.0016 17.7 0.5 1.6 7.8 0.0 2.7 3 0 0 3 3 3 2 NB-ARC domain AAA_16 PF13191.6 EFC39831.1 - 0.0023 18.3 0.1 2.3 8.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 EFC39831.1 - 0.0036 16.9 0.1 0.54 9.8 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 EFC39831.1 - 0.0062 16.5 0.0 2.9 7.8 0.0 2.6 2 0 0 2 2 2 1 NACHT domain FtsK_SpoIIIE PF01580.18 EFC39831.1 - 0.0081 15.5 0.7 1.6 8.0 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family Roc PF08477.13 EFC39831.1 - 0.012 15.9 0.7 6.2 7.1 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 EFC39831.1 - 0.012 15.2 0.0 5.6 6.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFC39831.1 - 0.022 14.5 0.9 1.7 8.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFC39831.1 - 0.022 15.1 0.2 4.1 7.8 0.0 3.1 3 0 0 3 3 2 0 RNA helicase Septin PF00735.18 EFC39831.1 - 0.042 13.1 1.3 9.1 5.5 0.0 3.0 3 0 0 3 3 3 0 Septin AAA_30 PF13604.6 EFC39831.1 - 0.047 13.4 0.1 7.3 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFC39831.1 - 0.055 14.0 12.0 0.084 13.4 0.6 3.8 4 0 0 4 4 3 0 AAA domain AAA_21 PF13304.6 EFC39831.1 - 0.1 12.4 4.8 4.5 7.0 0.1 3.3 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Viral_helicase1 PF01443.18 EFC39831.1 - 0.11 12.2 0.1 20 4.9 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 EFC39831.1 - 0.12 11.4 0.2 4.2 6.3 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 EFC39831.1 - 0.17 11.1 1.1 5.6 6.2 0.0 2.7 3 0 0 3 3 2 0 Zeta toxin cobW PF02492.19 EFC39831.1 - 0.29 10.7 2.4 13 5.3 0.2 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EFC39831.1 - 0.56 9.9 6.2 5.6 6.7 0.0 3.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 EFC39831.1 - 6.7 6.6 6.6 14 5.6 0.2 3.1 4 0 0 4 4 2 0 NTPase AMP-binding PF00501.28 EFC39832.1 - 6e-79 265.6 0.0 7.7e-79 265.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SRF-TF PF00319.18 EFC39833.1 - 1.3e-21 75.8 0.1 2.1e-21 75.1 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) MRI PF15325.6 EFC39833.1 - 1.7 9.8 5.9 2.7 9.1 0.2 2.9 2 1 1 3 3 3 0 Modulator of retrovirus infection G-alpha PF00503.20 EFC39834.1 - 7.5e-43 147.0 13.6 2e-41 142.3 13.6 2.1 1 1 0 1 1 1 1 G-protein alpha subunit DUF3619 PF12279.8 EFC39835.1 - 0.076 13.3 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) Rhodanese PF00581.20 EFC39836.1 - 3.3e-13 50.1 0.0 3.8e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain NDK PF00334.19 EFC39837.1 - 9.7e-56 187.5 0.0 1.1e-55 187.3 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Arrestin_N PF00339.29 EFC39838.1 - 9.2e-07 29.0 0.1 2.1e-06 27.8 0.1 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFC39838.1 - 9.8e-05 22.8 1.3 0.0034 17.8 0.1 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain HSP90 PF00183.18 EFC39839.1 - 1.5e-228 759.9 33.2 1.9e-228 759.6 33.2 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFC39839.1 - 2.3e-13 50.6 0.0 4.4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFC39839.1 - 9.2e-09 35.2 0.0 2.6e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 EFC39839.1 - 0.021 14.8 0.1 0.053 13.5 0.1 1.8 1 1 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN ProQ PF04352.13 EFC39839.1 - 0.07 13.0 0.3 0.27 11.2 0.1 2.2 2 0 0 2 2 2 0 ProQ/FINO family TipAS PF07739.13 EFC39839.1 - 2.7 8.6 7.4 1.1 9.9 0.1 3.7 3 1 0 3 3 3 0 TipAS antibiotic-recognition domain GOLD_2 PF13897.6 EFC39839.1 - 8 7.0 6.5 4.9 7.7 1.5 2.9 3 0 0 3 3 3 0 Golgi-dynamics membrane-trafficking RCC1 PF00415.18 EFC39840.1 - 7.8e-29 100.1 0.3 0.0017 19.0 0.0 10.2 10 0 0 10 10 10 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39840.1 - 1.4e-11 43.8 28.2 2.3e-05 24.0 0.0 7.8 10 0 0 10 10 10 3 Regulator of chromosome condensation (RCC1) repeat Ephrin_rec_like PF07699.13 EFC39840.1 - 7.7e-09 35.2 6.8 7.7e-09 35.2 6.8 4.5 3 1 1 4 4 4 2 Putative ephrin-receptor like AcrZ PF10766.9 EFC39840.1 - 0.16 11.6 2.6 0.45 10.1 2.6 1.7 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ LapA_dom PF06305.11 EFC39840.1 - 1.1 9.2 15.1 1 9.3 2.7 3.3 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF4834 PF16118.5 EFC39840.1 - 2.8 8.9 7.6 35 5.5 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) LRR_4 PF12799.7 EFC39841.1 - 0.00012 22.4 16.8 0.053 14.0 4.6 6.2 3 2 5 8 8 8 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39841.1 - 0.0093 15.7 11.2 0.9 9.3 3.9 4.3 3 1 0 3 3 3 2 Leucine rich repeat FNIP PF05725.12 EFC39841.1 - 0.016 15.3 6.7 0.032 14.4 1.6 3.4 3 0 0 3 3 3 0 FNIP Repeat DUF1699 PF08004.11 EFC39841.1 - 0.03 14.0 1.0 0.47 10.1 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1699) LRR_6 PF13516.6 EFC39841.1 - 0.066 13.3 7.1 4.3 7.6 0.0 4.9 5 0 0 5 5 5 0 Leucine Rich repeat AAA_16 PF13191.6 EFC39842.1 - 9.9e-07 29.3 0.1 6.3e-06 26.7 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain UPF0231 PF06062.11 EFC39842.1 - 0.00011 22.5 1.4 0.00011 22.5 1.4 3.3 3 1 1 4 4 4 1 Uncharacterised protein family (UPF0231) cobW PF02492.19 EFC39842.1 - 0.0012 18.5 0.2 0.0034 17.0 0.2 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 EFC39842.1 - 0.0074 16.0 0.1 0.017 14.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 EFC39842.1 - 0.0094 16.5 3.4 0.0094 16.5 3.4 3.4 4 1 0 4 4 4 1 ABC transporter T2SSE PF00437.20 EFC39842.1 - 0.011 14.8 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EFC39842.1 - 0.017 14.5 0.7 0.28 10.5 0.0 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family NTPase_1 PF03266.15 EFC39842.1 - 0.022 14.7 0.1 0.078 12.9 0.1 2.0 1 0 0 1 1 1 0 NTPase NACHT PF05729.12 EFC39842.1 - 0.024 14.6 0.0 0.088 12.7 0.0 2.0 1 0 0 1 1 1 0 NACHT domain TrwB_AAD_bind PF10412.9 EFC39842.1 - 0.025 13.5 0.6 0.053 12.4 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 EFC39842.1 - 0.026 14.6 2.3 0.13 12.3 0.3 3.2 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC39842.1 - 0.027 14.7 1.5 0.32 11.2 0.5 3.0 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFC39842.1 - 0.039 13.7 0.3 0.1 12.3 0.3 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain HATPase_c_5 PF14501.6 EFC39842.1 - 0.065 13.1 2.6 0.13 12.2 0.6 2.6 2 1 0 2 2 2 0 GHKL domain AAA PF00004.29 EFC39842.1 - 0.069 13.6 0.6 1.7 9.1 0.1 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 EFC39842.1 - 0.099 12.5 0.4 0.3 11.0 0.1 2.0 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 EFC39842.1 - 0.12 12.6 0.0 0.39 10.9 0.0 2.0 1 0 0 1 1 1 0 AAA domain MitMem_reg PF13012.6 EFC39842.1 - 0.71 10.3 4.8 1.4 9.4 0.5 3.3 2 2 0 2 2 2 0 Maintenance of mitochondrial structure and function Sigma54_activ_2 PF14532.6 EFC39842.1 - 0.78 9.9 2.9 1.2 9.2 0.0 2.9 4 0 0 4 4 3 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 EFC39842.1 - 5.5 6.7 7.0 15 5.3 0.1 3.0 1 1 2 3 3 3 0 Viral (Superfamily 1) RNA helicase Glucokinase PF02685.16 EFC39843.1 - 3.4e-28 98.6 0.0 9e-28 97.2 0.0 1.5 1 1 0 1 1 1 1 Glucokinase NAD_binding_1 PF00175.21 EFC39844.1 - 0.00043 20.9 0.0 0.00097 19.8 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFC39844.1 - 0.052 13.7 0.3 0.28 11.3 0.3 2.3 1 1 0 1 1 1 0 Ferric reductase NAD binding domain RasGEF PF00617.19 EFC39846.1 - 5.4e-42 144.0 1.6 1.1e-41 143.0 1.6 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFC39846.1 - 3.5e-17 62.5 3.9 1.6e-16 60.4 0.1 3.4 3 1 1 4 4 4 1 RasGEF N-terminal motif F-box PF00646.33 EFC39847.1 - 0.006 16.4 0.1 0.012 15.5 0.1 1.5 1 0 0 1 1 1 1 F-box domain Stm1_N PF09598.10 EFC39847.1 - 0.0072 17.1 0.1 0.015 16.1 0.1 1.6 1 0 0 1 1 1 1 Stm1 AHD PF17793.1 EFC39847.1 - 0.059 13.2 1.5 3.1 7.6 0.0 3.2 3 0 0 3 3 3 0 ANC1 homology domain (AHD) HTH_22 PF13309.6 EFC39847.1 - 0.28 11.3 1.5 8.8 6.5 0.4 2.8 2 0 0 2 2 2 0 HTH domain BtpA PF03437.15 EFC39848.1 - 5.3e-09 35.9 0.2 1.2e-08 34.7 0.1 1.6 2 0 0 2 2 2 1 BtpA family zf-RanBP PF00641.18 EFC39848.1 - 3.2 7.1 11.8 7.4 6.0 11.8 1.6 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others NFACT-R_1 PF05670.13 EFC39849.1 - 2.4e-20 73.2 0.4 3e-20 72.9 0.4 1.1 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-R_2 PF18297.1 EFC39849.1 - 4.8e-07 29.9 0.1 9.6e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 NFACT protein RNA binding domain Baculo_IE-1 PF05290.11 EFC39849.1 - 0.027 14.4 0.1 0.048 13.6 0.1 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) EGF_2 PF07974.13 EFC39850.1 - 2.2e-55 184.7 285.9 2.7e-05 24.5 7.6 17.7 17 0 0 17 17 17 17 EGF-like domain RGS PF00615.19 EFC39850.1 - 1.4e-09 38.2 0.7 4e-09 36.8 0.7 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain B_lectin PF01453.24 EFC39850.1 - 0.013 16.1 0.0 0.74 10.4 0.0 3.6 3 0 0 3 3 3 0 D-mannose binding lectin DUF5565 PF17720.1 EFC39851.1 - 9e-44 149.6 2.2 1.2e-43 149.3 2.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5565) Methyltransf_28 PF02636.17 EFC39851.1 - 0.042 13.5 0.2 0.064 12.9 0.2 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF3663 PF12404.8 EFC39851.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 Peptidase NLPC_P60 PF00877.19 EFC39853.1 - 0.085 12.9 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 NlpC/P60 family ubiquitin PF00240.23 EFC39854.1 - 1.4e-68 226.6 6.6 8.6e-34 115.1 0.7 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC39854.1 - 5.9e-34 115.7 6.8 1.8e-16 59.7 0.7 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC39854.1 - 9.9e-13 48.4 2.2 8.2e-05 23.0 0.2 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC39854.1 - 7.9e-09 35.8 1.1 0.0038 17.5 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC39854.1 - 9.6e-09 35.1 0.4 0.0048 16.8 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC39854.1 - 6.8e-08 32.6 0.7 0.02 15.0 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC39854.1 - 1.4e-06 28.8 0.1 0.038 14.5 0.2 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC39854.1 - 4e-06 26.8 8.6 1.8 8.7 0.2 4.0 4 0 0 4 4 4 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC39854.1 - 5.4e-06 26.3 0.0 0.1 12.4 0.0 2.1 2 0 0 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain DUF3861 PF12977.7 EFC39854.1 - 0.0028 17.8 0.2 3.5 7.9 0.0 2.2 2 0 0 2 2 2 2 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 EFC39854.1 - 0.0079 16.6 0.1 8.8 6.8 0.0 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF2870) ACT_5 PF13710.6 EFC39854.1 - 0.0083 15.9 0.7 4.3 7.3 0.1 2.4 2 0 0 2 2 2 2 ACT domain YcgR_2 PF12945.7 EFC39854.1 - 0.017 15.3 0.4 7.6 6.8 0.1 2.2 2 0 0 2 2 2 0 Flagellar protein YcgR ProRS-C_2 PF09181.10 EFC39854.1 - 0.021 14.9 1.8 6.2 7.0 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 EFC39854.1 - 0.035 14.3 2.2 6.9 7.0 0.2 2.4 2 0 0 2 2 2 0 Tash protein PEST motif RBD PF02196.15 EFC39854.1 - 0.039 14.0 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Raf-like Ras-binding domain UDP-g_GGTase PF06427.11 EFC39854.1 - 0.046 13.8 1.2 0.8 9.9 0.1 2.5 3 0 0 3 3 3 0 UDP-glucose:Glycoprotein Glucosyltransferase UN_NPL4 PF11543.8 EFC39854.1 - 0.047 14.2 0.3 13 6.3 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 DUF1866 PF08952.11 EFC39854.1 - 0.073 12.9 0.1 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) NETI PF14044.6 EFC39854.1 - 0.088 12.6 1.0 19 5.1 0.0 3.0 2 2 2 4 4 4 0 NETI protein FERM_f0 PF16511.5 EFC39854.1 - 0.15 12.4 1.7 31 5.0 0.1 3.2 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM Plexin_cytopl PF08337.12 EFC39854.1 - 0.16 10.6 3.7 5.9 5.4 0.4 2.9 3 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain PI3K_p85B PF02192.16 EFC39854.1 - 0.22 11.3 1.7 17 5.3 0.1 2.3 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain HAMP_N3 PF18575.1 EFC39854.1 - 0.32 10.6 1.1 24 4.6 0.1 2.3 2 0 0 2 2 2 0 HAMP N-terminal domain 3 LRR_9 PF14580.6 EFC39855.1 - 3.1e-15 56.1 1.1 1.6e-08 34.3 0.1 2.5 1 1 1 2 2 2 2 Leucine-rich repeat CAP_GLY PF01302.25 EFC39855.1 - 5.3e-14 52.0 0.1 1.2e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 EFC39855.1 - 2.5e-13 49.9 15.3 0.0015 18.8 0.4 5.6 3 2 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39855.1 - 3.5e-12 45.9 17.1 0.00013 21.6 0.1 4.7 3 2 2 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 EFC39855.1 - 0.00016 21.5 8.1 3.6 7.9 0.2 6.5 7 0 0 7 7 7 2 Leucine Rich repeat Ubiquitin_2 PF14560.6 EFC39855.1 - 0.00092 19.6 0.0 0.0027 18.1 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_1 PF00560.33 EFC39855.1 - 6.1 7.8 5.3 99 4.1 0.1 4.5 5 0 0 5 5 5 0 Leucine Rich Repeat hSac2 PF12456.8 EFC39856.1 - 2.4e-07 30.5 0.1 6.7e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 Inositol phosphatase Arm PF00514.23 EFC39856.1 - 0.00037 20.4 0.2 5.8 7.1 0.0 4.9 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat DUF4259 PF14078.6 EFC39856.1 - 0.17 12.6 1.4 9.4 7.0 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4259) LRR_4 PF12799.7 EFC39857.1 - 0.17 12.4 15.6 28 5.3 0.0 5.7 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) Pkinase PF00069.25 EFC39859.1 - 1.8e-36 125.9 1.5 4.1e-36 124.7 1.5 1.6 1 0 0 1 1 1 1 Protein kinase domain DUF4116 PF13475.6 EFC39859.1 - 3e-25 87.7 7.1 9.8e-12 44.4 0.0 6.4 6 1 1 7 7 7 3 Domain of unknown function (DUF4116) Sel1 PF08238.12 EFC39859.1 - 6.9e-22 77.4 22.5 4.6e-07 30.3 0.3 7.5 9 0 0 9 9 9 3 Sel1 repeat Pkinase_Tyr PF07714.17 EFC39859.1 - 1.4e-17 63.9 4.7 2.3e-16 59.9 1.3 2.9 2 1 0 2 2 2 1 Protein tyrosine kinase PX PF00787.24 EFC39859.1 - 5.9e-10 39.1 5.9 1.3e-09 38.0 4.5 2.3 2 0 0 2 2 2 1 PX domain TPR_8 PF13181.6 EFC39859.1 - 0.00013 21.9 3.9 0.16 12.3 0.4 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC39859.1 - 0.0014 18.4 5.6 0.15 11.9 0.3 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC39859.1 - 0.0043 17.3 1.0 10 6.5 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39859.1 - 0.025 14.7 8.1 2.2 8.6 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC39859.1 - 0.043 13.9 1.9 0.16 12.1 0.1 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat G-alpha PF00503.20 EFC39860.1 - 0.00014 21.1 6.6 0.0002 20.7 6.6 1.2 1 0 0 1 1 1 1 G-protein alpha subunit GIY-YIG PF01541.24 EFC39860.1 - 0.011 16.0 1.1 5.3 7.4 0.0 2.8 2 0 0 2 2 2 0 GIY-YIG catalytic domain OCRL_clath_bd PF16726.5 EFC39860.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Inositol polyphosphate 5-phosphatase clathrin binding domain Ank_2 PF12796.7 EFC39861.1 - 9.7e-09 35.7 0.0 1.6e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC39861.1 - 3.7e-08 33.5 0.1 7.3e-08 32.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 EFC39861.1 - 7e-08 32.6 0.0 1.3e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC39861.1 - 2.3e-06 27.5 0.0 1.1e-05 25.4 0.0 2.1 1 1 1 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EFC39861.1 - 1.1e-05 25.9 0.0 2.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) CMD PF02627.20 EFC39863.1 - 4.8e-06 26.5 0.0 9.7e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Pou PF00157.17 EFC39863.1 - 0.02 14.8 0.2 0.16 11.9 0.0 2.4 3 0 0 3 3 3 0 Pou domain - N-terminal to homeobox domain EF-hand_8 PF13833.6 EFC39863.1 - 0.082 12.8 0.3 1.3 8.9 0.0 2.6 3 0 0 3 3 3 0 EF-hand domain pair DUF2929 PF11151.8 EFC39863.1 - 0.17 12.2 0.0 1.4 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) LRR_6 PF13516.6 EFC39864.1 - 8.9e-06 25.4 4.6 1.2 9.4 0.1 4.6 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 EFC39864.1 - 0.0011 19.2 0.7 59 4.8 0.0 4.8 3 0 0 3 3 3 0 Leucine Rich Repeat SlyX PF04102.12 EFC39864.1 - 0.049 14.2 7.6 0.34 11.6 7.6 2.6 1 0 0 1 1 1 0 SlyX NAAA-beta PF15508.6 EFC39864.1 - 0.12 12.6 0.0 0.38 11.1 0.0 1.8 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Tweety PF04906.13 EFC39864.1 - 0.5 9.0 4.4 0.83 8.3 4.4 1.3 1 0 0 1 1 1 0 Tweety FAA_hydro_N_2 PF18288.1 EFC39864.1 - 1.7 9.1 4.0 10 6.6 1.6 2.6 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 SNARE PF05739.19 EFC39865.1 - 1.3e-05 25.0 0.7 3.6e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EFC39865.1 - 0.017 14.8 30.0 0.024 14.3 0.2 3.2 2 1 1 3 3 3 0 Syntaxin T2SSF PF00482.23 EFC39865.1 - 0.066 13.2 0.9 0.27 11.2 0.0 2.3 2 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Ras PF00071.22 EFC39866.1 - 5.7e-33 113.8 0.0 1e-32 113.0 0.0 1.4 1 0 0 1 1 1 1 Ras family Kelch_4 PF13418.6 EFC39866.1 - 1.3e-22 79.5 0.0 5.5e-06 26.3 0.0 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC39866.1 - 3.1e-21 75.2 0.0 2.6e-05 24.4 0.0 5.5 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC39866.1 - 2.7e-19 68.7 0.4 0.0025 17.8 0.0 5.4 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EFC39866.1 - 3.2e-14 52.6 0.6 0.0015 18.8 0.0 5.8 5 0 0 5 5 5 2 Kelch motif Roc PF08477.13 EFC39866.1 - 8.9e-14 51.7 0.0 1.9e-13 50.7 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Kelch_1 PF01344.25 EFC39866.1 - 2.5e-13 49.4 0.9 0.00012 21.6 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EFC39866.1 - 2.1e-08 33.8 4.7 0.076 13.0 0.0 5.6 7 0 0 7 7 7 3 Kelch motif F-box PF00646.33 EFC39866.1 - 7.3e-05 22.5 1.9 0.00022 21.0 1.9 1.8 1 0 0 1 1 1 1 F-box domain GTP_EFTU PF00009.27 EFC39866.1 - 0.0014 18.2 0.0 0.0026 17.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 EFC39866.1 - 0.003 17.4 0.3 0.0073 16.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like PduV-EutP PF10662.9 EFC39866.1 - 0.018 14.8 0.0 0.5 10.1 0.0 2.5 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CH PF00307.31 EFC39867.1 - 4.7e-22 78.2 0.0 7.4e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain SHOCT PF09851.9 EFC39867.1 - 5.8e-10 38.6 6.1 1.1e-09 37.7 6.1 1.5 1 0 0 1 1 1 1 Short C-terminal domain DUF2847 PF11009.8 EFC39867.1 - 0.034 14.0 2.1 0.18 11.7 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2847) Ras PF00071.22 EFC39869.1 - 7e-30 103.8 0.0 1.2e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC39869.1 - 2.6e-21 76.1 0.0 5e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC39869.1 - 1.6e-07 30.9 0.0 3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC39869.1 - 0.00025 20.5 0.0 0.00057 19.3 0.0 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC39869.1 - 0.00027 21.0 0.0 0.00049 20.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EFC39869.1 - 0.00082 19.1 0.1 0.0024 17.6 0.0 1.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFC39869.1 - 0.0039 16.9 0.1 0.0065 16.2 0.1 1.5 1 1 0 1 1 1 1 AAA domain F-box-like PF12937.7 EFC39869.1 - 0.014 15.3 0.1 0.033 14.1 0.1 1.6 1 0 0 1 1 1 0 F-box-like ATP_bind_1 PF03029.17 EFC39869.1 - 0.019 14.7 0.0 0.058 13.2 0.0 1.7 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein Sigma54_activat PF00158.26 EFC39869.1 - 0.028 14.1 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EFC39869.1 - 0.038 14.3 0.0 0.14 12.4 0.0 2.0 1 1 1 2 2 2 0 AAA domain RuvB_N PF05496.12 EFC39869.1 - 0.056 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 EFC39869.1 - 0.086 12.2 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 EFC39869.1 - 0.18 12.2 0.0 0.43 10.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain SBP_bac_3 PF00497.20 EFC39870.1 - 1.8e-14 53.8 0.0 2.5e-12 46.7 0.0 2.1 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 Pkinase PF00069.25 EFC39871.1 - 3.3e-28 98.8 0.9 4.3e-25 88.6 0.9 3.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39871.1 - 8.4e-17 61.3 0.1 4.5e-14 52.4 0.0 3.1 1 1 2 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC39871.1 - 9.9e-09 34.5 0.0 1.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC39871.1 - 0.0021 17.5 0.1 0.0057 16.0 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EFC39871.1 - 0.011 15.2 0.0 0.022 14.3 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kinase-like PF14531.6 EFC39871.1 - 0.022 14.1 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFC39871.1 - 0.032 14.2 0.0 0.081 12.8 0.0 1.6 1 1 0 2 2 2 0 Phosphotransferase enzyme family TEX33 PF15400.6 EFC39871.1 - 0.065 13.7 0.1 0.12 12.9 0.1 1.5 1 0 0 1 1 1 0 Testis-expressed sequence 33 protein family LRR_6 PF13516.6 EFC39872.1 - 1.4e-91 292.9 29.7 1.1e-05 25.0 0.0 18.3 18 0 0 18 18 18 18 Leucine Rich repeat LRR_8 PF13855.6 EFC39872.1 - 4.4e-51 170.5 17.5 8.5e-08 31.9 1.0 7.9 7 1 1 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC39872.1 - 7.2e-45 150.2 27.7 1.2e-05 25.6 0.9 10.8 4 3 10 14 14 14 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC39872.1 - 1.2e-25 86.1 2.3 3.6 8.5 0.0 15.2 16 0 0 16 16 16 5 Leucine Rich Repeat LRR_9 PF14580.6 EFC39872.1 - 6.6e-10 38.8 11.1 0.055 13.0 0.7 5.6 1 1 4 6 6 6 6 Leucine-rich repeat DUF4347 PF14252.6 EFC39872.1 - 5.1e-09 36.2 2.1 2.9 7.7 0.0 7.9 1 1 5 9 9 9 2 Domain of unknown function (DUF4347) DUF424 PF04242.13 EFC39872.1 - 0.00066 19.9 16.1 8.7 6.7 0.1 8.1 2 2 3 8 8 8 1 Protein of unknown function (DUF424) Beta_helix PF13229.6 EFC39872.1 - 0.018 14.9 23.3 0.059 13.2 3.1 3.6 1 1 2 3 3 3 0 Right handed beta helix region ApoB100_C PF12491.8 EFC39872.1 - 0.29 11.1 20.5 9.6 6.3 0.0 8.8 8 5 4 12 12 12 0 Apolipoprotein B100 C terminal bZIP_C PF12498.8 EFC39872.1 - 0.83 10.6 4.1 15 6.6 0.1 4.4 1 1 4 6 6 6 0 Basic leucine-zipper C terminal Pkinase_Tyr PF07714.17 EFC39873.1 - 6.7e-52 176.3 0.1 7.2e-48 163.1 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC39873.1 - 1.2e-44 152.7 0.1 2.5e-44 151.6 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFC39873.1 - 0.026 14.4 0.0 0.042 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cass2 PF14526.6 EFC39875.1 - 4.3e-18 65.9 1.0 5.2e-18 65.6 1.0 1.0 1 0 0 1 1 1 1 Integron-associated effector binding protein GyrI-like PF06445.15 EFC39875.1 - 2.2e-08 34.5 0.3 2.8e-08 34.2 0.3 1.1 1 0 0 1 1 1 1 GyrI-like small molecule binding domain HlyIII PF03006.20 EFC39876.1 - 5.4e-51 173.5 22.8 7.5e-51 173.0 22.8 1.2 1 0 0 1 1 1 1 Haemolysin-III related SelP_N PF04592.14 EFC39876.1 - 1.5 8.2 12.4 2.3 7.6 12.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Slx4 PF09494.10 EFC39877.1 - 0.072 13.1 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Slx4 endonuclease Alanine_zipper PF11839.8 EFC39878.1 - 0.006 16.9 7.5 0.006 16.9 7.5 6.7 3 2 4 7 7 7 2 Alanine-zipper, major outer membrane lipoprotein HisKA_3 PF07730.13 EFC39878.1 - 3.2 8.3 27.2 8 7.1 0.2 6.3 2 2 2 6 6 6 0 Histidine kinase DUF2564 PF10819.8 EFC39878.1 - 5.6 7.4 55.6 2.6 8.5 8.7 6.0 3 2 2 6 6 6 0 Protein of unknown function (DUF2564) Presenilin PF01080.17 EFC39879.1 - 1.9 7.1 7.4 0.17 10.6 2.9 1.5 2 0 0 2 2 2 0 Presenilin DUF4498 PF14926.6 EFC39881.1 - 7.9e-17 61.4 7.2 5.6e-16 58.6 7.2 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4498) CdiI_4 PF18624.1 EFC39881.1 - 0.025 15.0 0.1 0.11 13.0 0.1 2.1 2 0 0 2 2 2 0 CDI immunity protein RWP-RK PF02042.15 EFC39882.1 - 3e-11 43.1 0.0 1.1e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 RWP-RK domain CTP_transf_like PF01467.26 EFC39883.1 - 0.00062 20.0 0.0 0.39 10.9 0.0 2.9 2 0 0 2 2 2 2 Cytidylyltransferase-like DUF4263 PF14082.6 EFC39883.1 - 0.05 13.9 0.4 0.92 9.8 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4263) FumaraseC_C PF10415.9 EFC39883.1 - 0.15 12.5 0.0 0.36 11.3 0.0 1.7 1 0 0 1 1 1 0 Fumarase C C-terminus MTS PF05175.14 EFC39884.1 - 9.4e-11 41.5 0.0 2.2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFC39884.1 - 2.1e-06 27.4 0.1 4.6e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) N6_Mtase PF02384.16 EFC39884.1 - 0.00025 20.4 0.4 0.00053 19.3 0.4 1.5 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_16 PF10294.9 EFC39884.1 - 0.00042 20.1 0.1 0.0012 18.6 0.1 1.7 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 EFC39884.1 - 0.00073 20.2 0.0 0.0019 18.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC39884.1 - 0.0011 18.8 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC39884.1 - 0.0013 18.5 0.1 0.003 17.4 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC39884.1 - 0.012 16.3 0.0 0.054 14.2 0.0 2.2 1 0 0 1 1 1 0 Methyltransferase domain Maf1 PF09174.10 EFC39885.1 - 9.3e-39 133.4 1.6 1.7e-38 132.5 1.6 1.5 1 0 0 1 1 1 1 Maf1 regulator YfkB PF08756.10 EFC39885.1 - 0.034 13.9 0.2 0.17 11.7 0.0 2.0 2 0 0 2 2 2 0 YfkB-like domain DUF3873 PF12989.7 EFC39885.1 - 0.19 12.1 1.9 2.4 8.6 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3873) Invasin_D3 PF09134.10 EFC39886.1 - 0.00061 20.0 0.2 0.0023 18.2 0.1 2.1 2 0 0 2 2 2 1 Invasin, domain 3 Filamin PF00630.19 EFC39886.1 - 0.1 13.4 0.1 0.3 11.9 0.0 1.8 2 0 0 2 2 2 0 Filamin/ABP280 repeat RNase_J_C PF17770.1 EFC39887.1 - 0.037 15.1 0.5 27 5.9 0.0 3.9 4 0 0 4 4 4 0 Ribonuclease J C-terminal domain RWP-RK PF02042.15 EFC39888.1 - 4e-05 23.5 0.0 0.00015 21.7 0.0 1.9 2 0 0 2 2 2 1 RWP-RK domain SR-25 PF10500.9 EFC39888.1 - 0.027 14.1 5.3 0.037 13.6 5.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ACOX PF01756.19 EFC39889.1 - 5e-27 94.6 0.0 1e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFC39889.1 - 1.1e-16 60.8 0.0 1.7e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFC39889.1 - 0.0013 18.9 0.1 0.0053 17.0 0.1 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 EFC39889.1 - 0.0051 17.4 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal DUF4773 PF15998.5 EFC39890.1 - 0.0028 18.2 0.7 0.0051 17.3 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4773) Pkinase PF00069.25 EFC39891.1 - 2e-09 37.2 0.0 4.3e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39891.1 - 0.055 12.7 0.0 0.086 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Copine PF07002.16 EFC39893.1 - 1.9e-72 243.3 0.0 2.6e-72 242.8 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFC39893.1 - 4.6e-21 75.0 2.9 1.8e-09 37.8 1.5 3.3 2 1 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFC39893.1 - 0.00052 20.2 0.0 0.0014 18.8 0.0 1.7 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA_3 PF13768.6 EFC39893.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain CN_hydrolase PF00795.22 EFC39894.1 - 6.9e-52 176.4 0.0 8.9e-52 176.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF2267 PF10025.9 EFC39894.1 - 0.014 15.6 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) DUF3377 PF11857.8 EFC39894.1 - 0.51 10.3 2.3 1.1 9.3 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DCD PF06559.11 EFC39895.1 - 0.017 13.9 0.0 0.092 11.5 0.0 1.9 1 1 1 2 2 2 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) dUTPase PF00692.19 EFC39895.1 - 0.032 13.9 0.0 0.062 13.0 0.0 1.5 1 0 0 1 1 1 0 dUTPase SelP_N PF04592.14 EFC39896.1 - 0.36 10.2 11.3 0.53 9.7 11.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Cullin PF00888.22 EFC39897.1 - 1e-164 549.6 19.8 1.4e-164 549.1 19.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFC39897.1 - 8e-25 86.7 2.6 8e-25 86.7 2.6 3.0 3 0 0 3 3 3 1 Cullin protein neddylation domain DHHA2 PF02833.14 EFC39897.1 - 0.0082 16.3 1.6 0.063 13.5 0.0 3.2 3 1 1 4 4 4 1 DHHA2 domain UPF0167 PF03691.14 EFC39897.1 - 0.012 15.4 0.0 0.045 13.5 0.0 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) Pkinase PF00069.25 EFC39898.1 - 4.1e-48 164.0 1.7 5.3e-27 94.8 1.5 3.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39898.1 - 2.2e-23 82.9 1.1 3.7e-18 65.8 0.8 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EFC39898.1 - 0.0025 17.2 0.1 0.0062 15.9 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC39898.1 - 0.023 14.6 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family CtnDOT_TraJ PF07863.11 EFC39898.1 - 3.7 8.3 6.0 0.66 10.7 0.3 2.7 3 0 0 3 3 3 0 Homologues of TraJ from Bacteroides conjugative transposon SR-25 PF10500.9 EFC39899.1 - 0.00021 21.0 22.1 0.0003 20.5 22.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MAP65_ASE1 PF03999.12 EFC39899.1 - 0.0069 15.2 13.9 0.0082 14.9 13.9 1.0 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Chorion_2 PF03964.15 EFC39899.1 - 0.014 16.2 5.3 0.019 15.8 5.3 1.3 1 0 0 1 1 1 0 Chorion family 2 Sec62 PF03839.16 EFC39899.1 - 0.23 10.9 6.1 0.3 10.6 6.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Apt1 PF10351.9 EFC39899.1 - 0.32 9.8 14.8 0.33 9.8 14.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EFC39899.1 - 0.51 8.8 19.1 0.57 8.7 19.1 1.0 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 EFC39899.1 - 0.52 8.4 11.4 0.59 8.2 11.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NUC194 PF08163.12 EFC39899.1 - 0.83 8.5 10.5 0.98 8.3 10.5 1.1 1 0 0 1 1 1 0 NUC194 domain CDK2AP PF09806.9 EFC39899.1 - 1 9.3 12.4 1.4 9.0 12.4 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein FAM70 PF14967.6 EFC39899.1 - 1.8 7.9 6.1 2.2 7.7 6.1 1.1 1 0 0 1 1 1 0 FAM70 protein PAP1 PF08601.10 EFC39899.1 - 2.9 7.5 21.9 3.6 7.2 21.9 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Miga PF10265.9 EFC39899.1 - 3.2 6.6 12.0 3.6 6.5 12.0 1.1 1 0 0 1 1 1 0 Mitoguardin Shisa PF13908.6 EFC39899.1 - 3.3 7.9 7.7 4.3 7.5 7.7 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator FAM220 PF15487.6 EFC39899.1 - 3.8 7.1 19.7 32 4.0 19.7 1.9 1 1 0 1 1 1 0 FAM220 family Herpes_pp85 PF04637.12 EFC39899.1 - 4 5.7 13.7 4.7 5.5 13.7 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RCC1_2 PF13540.6 EFC39900.1 - 0.058 13.2 1.7 0.92 9.4 0.0 3.1 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat CitMHS PF03600.16 EFC39901.1 - 0.02 14.1 3.6 0.025 13.8 3.6 1.3 1 0 0 1 1 1 0 Citrate transporter DUF2070 PF09843.9 EFC39901.1 - 1 7.6 14.3 1.1 7.5 14.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Kelch_4 PF13418.6 EFC39902.1 - 2.2e-27 94.8 17.1 1.7e-08 34.4 0.1 6.2 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC39902.1 - 1.8e-17 63.2 15.3 0.00029 21.0 0.1 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC39902.1 - 3.5e-15 55.7 10.9 0.017 15.4 0.3 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 EFC39902.1 - 2.5e-14 52.9 11.5 0.00032 20.6 0.2 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EFC39902.1 - 1.1e-09 37.9 7.7 0.024 14.6 0.1 4.8 4 1 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EFC39902.1 - 1.7e-08 33.9 16.8 0.0053 16.3 0.2 5.3 6 0 0 6 6 6 3 Kelch motif RCC1_2 PF13540.6 EFC39902.1 - 0.014 15.2 1.7 0.042 13.7 1.7 1.8 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat DUF4476 PF14771.6 EFC39903.1 - 3.8e-24 84.8 8.7 8.6e-23 80.5 5.4 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) OMP_b-brl_2 PF13568.6 EFC39903.1 - 0.023 14.7 7.1 0.083 12.9 3.3 2.6 1 1 2 3 3 3 0 Outer membrane protein beta-barrel domain OMP_b-brl PF13505.6 EFC39903.1 - 0.18 11.9 7.9 0.45 10.6 7.8 1.6 1 1 0 1 1 1 0 Outer membrane protein beta-barrel domain DUF3769 PF12600.8 EFC39903.1 - 0.71 8.7 4.4 0.81 8.5 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3769) Pericardin_rpt PF07054.11 EFC39903.1 - 7.4 6.8 8.2 4.2 7.6 1.3 3.1 3 0 0 3 3 3 0 Pericardin like repeat EcKinase PF02958.20 EFC39904.1 - 1.8e-16 60.3 2.3 4.9e-16 58.9 2.4 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EFC39904.1 - 1.5e-09 37.2 5.8 3.3e-08 32.8 5.8 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.23 EFC39904.1 - 3.6e-07 30.4 0.0 5.4e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC39904.1 - 0.00015 21.4 1.6 0.00032 20.3 1.6 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF2207 PF09972.9 EFC39905.1 - 0.0002 20.3 3.5 0.00026 19.9 3.5 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) GRP PF07172.11 EFC39905.1 - 0.023 15.4 16.2 0.062 14.0 16.2 1.8 1 0 0 1 1 1 0 Glycine rich protein family Shisa PF13908.6 EFC39905.1 - 0.041 14.1 0.1 0.069 13.4 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator PseudoU_synth_2 PF00849.22 EFC39906.1 - 1e-28 100.5 0.7 1.3e-27 96.9 0.0 2.6 3 0 0 3 3 3 1 RNA pseudouridylate synthase PPR_2 PF13041.6 EFC39907.1 - 1.6e-45 153.1 12.8 5.5e-13 48.9 0.0 8.9 7 2 2 9 9 9 5 PPR repeat family PPR PF01535.20 EFC39907.1 - 3.5e-37 124.0 16.7 0.00078 19.5 0.0 12.3 12 0 0 12 12 12 9 PPR repeat DYW_deaminase PF14432.6 EFC39907.1 - 1.9e-29 102.1 1.9 2.9e-29 101.5 0.7 1.9 2 0 0 2 2 2 1 DYW family of nucleic acid deaminases PPR_3 PF13812.6 EFC39907.1 - 3.5e-25 87.9 10.3 9.5e-10 38.4 0.0 6.1 5 2 2 7 7 7 4 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC39907.1 - 2.8e-14 53.0 0.0 2.9e-09 36.6 0.0 3.4 3 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFC39907.1 - 1.3e-10 40.8 13.9 0.02 14.6 0.1 8.3 8 1 1 9 9 9 3 PPR repeat AEP1 PF17049.5 EFC39907.1 - 0.0009 18.4 2.2 0.28 10.2 0.0 3.1 2 1 1 3 3 3 2 ATPase expression protein 1 RPN7 PF10602.9 EFC39907.1 - 0.0053 16.5 0.9 14 5.4 0.0 5.1 4 3 3 7 7 7 1 26S proteasome subunit RPN7 TPR_14 PF13428.6 EFC39907.1 - 0.0058 17.3 0.0 34 5.6 0.0 4.8 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC39907.1 - 0.007 16.5 5.7 28 5.3 0.3 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Aldo_ket_red PF00248.21 EFC39907.1 - 0.035 13.3 0.0 0.067 12.4 0.0 1.4 1 0 0 1 1 1 0 Aldo/keto reductase family CCDC85 PF10226.9 EFC39907.1 - 0.16 11.6 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 CCDC85 family ABC_tran PF00005.27 EFC39908.1 - 2.8e-29 102.4 0.0 1.2e-28 100.3 0.0 2.0 2 0 0 2 2 2 1 ABC transporter ABC2_membrane PF01061.24 EFC39908.1 - 2.1e-17 63.2 10.4 2.1e-17 63.2 10.4 1.9 2 0 0 2 2 2 1 ABC-2 type transporter AAA_21 PF13304.6 EFC39908.1 - 0.00012 22.0 0.9 0.04 13.7 0.2 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC39908.1 - 0.00052 19.9 0.1 0.0011 18.9 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC39908.1 - 0.00097 18.8 0.4 0.0027 17.4 0.4 1.8 1 1 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFC39908.1 - 0.001 18.6 0.1 0.0072 15.8 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF4446 PF14584.6 EFC39908.1 - 0.0055 16.7 1.1 0.016 15.2 1.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) AAA_23 PF13476.6 EFC39908.1 - 0.014 15.9 0.2 0.014 15.9 0.2 2.8 2 1 1 3 3 3 0 AAA domain EGF PF00008.27 EFC39908.1 - 0.072 13.4 17.3 0.29 11.5 3.7 4.5 3 1 1 4 4 4 0 EGF-like domain cEGF PF12662.7 EFC39908.1 - 0.14 12.1 5.4 2.1 8.3 0.1 3.2 2 0 0 2 2 2 0 Complement Clr-like EGF-like AAA_16 PF13191.6 EFC39908.1 - 0.18 12.2 0.0 0.33 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain hEGF PF12661.7 EFC39908.1 - 5.4 7.8 28.1 0.045 14.4 4.5 4.5 5 0 0 5 5 5 0 Human growth factor-like EGF RCC1 PF00415.18 EFC39909.1 - 1.6e-35 121.5 1.1 1.1e-11 45.1 0.0 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39909.1 - 8.3e-21 73.3 12.8 0.00034 20.3 0.1 7.1 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat ZZ PF00569.17 EFC39910.1 - 5.2e-10 39.0 7.5 9.2e-10 38.2 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 EFC39910.1 - 4.9e-07 29.6 0.0 1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 PB1 domain FPN1 PF06963.12 EFC39911.1 - 1e-101 340.7 18.0 1.2e-101 340.4 18.0 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) F-box-like PF12937.7 EFC39912.1 - 0.0013 18.6 0.7 0.0033 17.3 0.3 1.9 2 0 0 2 2 2 1 F-box-like SGT1 PF07093.11 EFC39913.1 - 1.5e-74 251.5 14.5 1.9e-74 251.2 14.5 1.1 1 0 0 1 1 1 1 SGT1 protein Pentapeptide_4 PF13599.6 EFC39915.1 - 3.3e-20 72.0 64.8 6.9e-05 22.9 11.2 6.6 1 1 3 5 5 5 4 Pentapeptide repeats (9 copies) TLD PF07534.16 EFC39915.1 - 7.8e-17 61.8 3.1 7.8e-17 61.8 3.1 3.4 3 0 0 3 3 3 1 TLD Pentapeptide PF00805.22 EFC39915.1 - 8.2e-11 41.3 31.7 4e-05 23.2 0.6 8.0 5 2 1 7 7 7 3 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 EFC39915.1 - 2.1e-09 37.4 56.2 0.00061 19.9 8.4 7.5 4 2 4 8 8 8 6 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC39915.1 - 0.00031 21.0 0.1 0.0016 18.8 0.1 2.3 1 0 0 1 1 1 1 BTB/POZ domain Beta_helix PF13229.6 EFC39915.1 - 0.0097 15.8 2.9 0.0097 15.8 2.9 2.9 1 1 1 2 2 2 2 Right handed beta helix region CENP-B_dimeris PF09026.10 EFC39915.1 - 0.016 15.6 2.3 0.029 14.7 2.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-RING_6 PF14835.6 EFC39915.1 - 0.024 14.5 3.1 0.11 12.4 3.1 2.2 1 0 0 1 1 1 0 zf-RING of BARD1-type protein RNA_pol_3_Rpc31 PF11705.8 EFC39915.1 - 0.038 14.2 5.9 0.059 13.6 5.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 HTH_40 PF14493.6 EFC39915.1 - 0.062 13.8 0.5 2.6 8.5 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain FYDLN_acid PF09538.10 EFC39915.1 - 0.43 11.3 7.2 0.092 13.4 3.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF4116 PF13475.6 EFC39916.1 - 3.1e-30 103.7 28.6 1.4e-09 37.6 0.0 9.5 9 1 1 10 10 10 8 Domain of unknown function (DUF4116) LRR_6 PF13516.6 EFC39917.1 - 5.2e-07 29.2 40.8 0.052 13.6 0.3 10.9 12 0 0 12 12 12 5 Leucine Rich repeat LRR_8 PF13855.6 EFC39917.1 - 4.3e-05 23.2 46.9 0.088 12.6 7.8 9.0 6 3 2 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EFC39917.1 - 0.00019 21.8 69.8 0.062 13.7 0.6 10.6 5 3 6 11 11 11 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC39917.1 - 0.0034 17.3 0.0 0.011 15.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like LRR_9 PF14580.6 EFC39917.1 - 0.82 9.2 29.3 0.18 11.3 0.9 5.0 2 2 3 6 6 6 0 Leucine-rich repeat G8 PF10162.9 EFC39918.1 - 1.5e-14 54.2 0.2 5.2e-14 52.4 0.2 2.0 1 0 0 1 1 1 1 G8 domain EGF_2 PF07974.13 EFC39918.1 - 3.5e-11 43.3 60.6 1.3e-05 25.4 6.4 4.9 4 0 0 4 4 4 4 EGF-like domain EGF PF00008.27 EFC39918.1 - 0.0022 18.2 2.2 0.0022 18.2 2.2 5.2 5 0 0 5 5 5 2 EGF-like domain EGF_Tenascin PF18720.1 EFC39918.1 - 0.016 15.2 1.3 0.016 15.2 1.3 3.5 4 0 0 4 4 4 0 Tenascin EGF domain CHRD PF07452.12 EFC39918.1 - 0.1 13.5 0.0 0.22 12.5 0.0 1.6 1 0 0 1 1 1 0 CHRD domain Beta_helix PF13229.6 EFC39918.1 - 3.5 7.5 26.4 0.19 11.5 11.7 4.2 3 1 0 3 3 3 0 Right handed beta helix region zf-A20 PF01754.16 EFC39920.1 - 1.2e-07 31.6 12.0 2.1e-07 30.8 12.0 1.4 1 0 0 1 1 1 1 A20-like zinc finger F-box-like PF12937.7 EFC39920.1 - 2.8e-05 23.9 0.0 5.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 F-box-like PRORP PF16953.5 EFC39920.1 - 0.0011 18.5 0.9 0.087 12.3 0.3 2.3 2 0 0 2 2 2 1 Protein-only RNase P DUF16 PF01519.16 EFC39920.1 - 0.018 15.6 2.8 0.16 12.5 2.9 2.4 3 0 0 3 3 3 0 Protein of unknown function DUF16 F-box PF00646.33 EFC39920.1 - 0.018 14.9 0.0 0.031 14.2 0.0 1.5 1 0 0 1 1 1 0 F-box domain Fmp27_SW PF10305.9 EFC39920.1 - 0.11 13.2 1.2 0.32 11.7 1.2 1.7 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Holin_SPP1 PF04688.13 EFC39920.1 - 0.15 12.2 0.6 0.38 10.9 0.1 1.9 2 0 0 2 2 2 0 SPP1 phage holin EMC3_TMCO1 PF01956.16 EFC39920.1 - 0.24 11.1 0.5 0.42 10.3 0.5 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ArfGap PF01412.18 EFC39920.1 - 1.2 9.3 4.5 0.98 9.5 0.8 2.4 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf PALP PF00291.25 EFC39921.1 - 1.1e-62 212.1 0.1 1.2e-62 212.0 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 EFC39921.1 - 0.069 13.1 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase RCC1 PF00415.18 EFC39922.1 - 3.5e-20 72.3 0.3 0.0013 19.3 0.0 8.0 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39922.1 - 6.4e-15 54.5 0.8 0.00027 20.6 0.0 4.9 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat FucT_N PF18025.1 EFC39922.1 - 0.088 13.3 1.5 9.9 6.7 0.1 2.9 2 0 0 2 2 2 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain Aminotran_3 PF00202.21 EFC39923.1 - 2.5e-79 266.8 0.0 3.2e-79 266.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III adh_short PF00106.25 EFC39924.1 - 2.4e-20 72.8 0.0 1.3e-17 63.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39924.1 - 9.7e-10 38.4 0.0 3.8e-09 36.5 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39924.1 - 3.8e-08 33.5 0.0 5e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC39924.1 - 0.014 14.9 0.0 0.038 13.4 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC39924.1 - 0.16 11.3 0.0 0.34 10.3 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Ntox44 PF15607.6 EFC39925.1 - 0.092 13.1 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial toxin 44 LRR_8 PF13855.6 EFC39926.1 - 5.5e-11 42.1 16.0 1e-08 34.8 6.5 5.5 3 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC39926.1 - 6.3e-09 36.0 39.3 1.3e-05 25.4 2.6 7.4 1 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC39926.1 - 0.0017 17.9 1.6 0.0017 17.9 1.6 2.7 2 2 0 2 2 2 1 Leucine-rich repeat F-box-like PF12937.7 EFC39926.1 - 0.015 15.2 0.9 0.015 15.2 0.9 1.9 2 0 0 2 2 2 0 F-box-like LRR_6 PF13516.6 EFC39926.1 - 0.024 14.7 22.4 0.33 11.1 0.2 6.5 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 EFC39926.1 - 0.9 10.3 29.9 3.4 8.6 0.1 7.2 7 2 0 7 7 7 0 Leucine Rich Repeat ubiquitin PF00240.23 EFC39927.1 - 2e-120 392.7 16.4 3.3e-33 113.2 0.7 4.0 3 1 1 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EFC39927.1 - 3.3e-57 190.2 16.8 6.7e-16 57.9 0.7 4.0 3 1 1 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC39927.1 - 2.3e-20 72.9 9.1 0.00028 21.3 0.2 5.4 3 3 1 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC39927.1 - 5.4e-17 61.5 0.9 0.015 15.2 0.1 4.2 3 1 1 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC39927.1 - 2.9e-15 56.4 7.3 0.013 15.8 0.1 4.1 1 1 3 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC39927.1 - 1.7e-13 50.7 3.4 0.065 13.3 0.0 5.0 3 3 1 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC39927.1 - 1.9e-12 47.6 1.6 0.035 14.7 0.1 4.1 1 1 2 4 4 4 3 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC39927.1 - 2.1e-08 34.1 20.6 4.7 7.3 0.2 7.9 7 1 1 8 8 8 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC39927.1 - 2.5e-07 30.7 0.1 0.4 10.5 0.0 3.7 2 1 2 4 4 4 2 Silencing defective 2 N-terminal ubiquitin domain DUF3861 PF12977.7 EFC39927.1 - 5.6e-05 23.2 1.0 9.3 6.5 0.0 4.0 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 EFC39927.1 - 6.3e-05 23.3 0.3 28 5.2 0.0 4.8 4 3 0 4 4 4 0 Protein of unknown function (DUF2870) UDP-g_GGTase PF06427.11 EFC39927.1 - 0.00067 19.8 0.8 2 8.6 0.1 2.8 2 0 0 2 2 2 2 UDP-glucose:Glycoprotein Glucosyltransferase Methyltrans_RNA PF04452.14 EFC39927.1 - 0.00081 18.8 0.3 1.2 8.4 0.0 2.3 2 0 0 2 2 2 2 RNA methyltransferase ACT_5 PF13710.6 EFC39927.1 - 0.0019 18.0 2.8 11 6.0 0.1 3.4 3 0 0 3 3 3 0 ACT domain ProRS-C_2 PF09181.10 EFC39927.1 - 0.0022 18.1 9.2 15 5.8 0.1 4.2 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal UN_NPL4 PF11543.8 EFC39927.1 - 0.0024 18.3 1.6 42 4.7 0.0 4.1 3 1 1 4 4 4 0 Nuclear pore localisation protein NPL4 DUF218 PF02698.17 EFC39927.1 - 0.0032 17.5 2.1 1.3 9.0 0.0 3.3 1 1 1 3 3 3 1 DUF218 domain RBD PF02196.15 EFC39927.1 - 0.0035 17.4 0.0 37 4.5 0.0 3.6 3 0 0 3 3 3 0 Raf-like Ras-binding domain DUF969 PF06149.12 EFC39927.1 - 0.011 15.2 0.0 21 4.4 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF969) YcgR_2 PF12945.7 EFC39927.1 - 0.012 15.7 2.7 21 5.4 0.1 3.4 3 0 0 3 3 3 0 Flagellar protein YcgR Tash_PEST PF07708.11 EFC39927.1 - 0.016 15.3 6.8 15 5.9 0.2 3.4 3 0 0 3 3 3 0 Tash protein PEST motif Big_7 PF17957.1 EFC39927.1 - 0.04 14.7 0.0 1.3e+02 3.4 0.0 3.7 4 0 0 4 4 4 0 Bacterial Ig domain ACT_4 PF13291.6 EFC39927.1 - 0.071 13.7 0.4 1.2e+02 3.3 0.0 3.4 3 0 0 3 3 3 0 ACT domain ORF11CD3 PF10549.9 EFC39927.1 - 0.13 12.5 0.0 87 3.4 0.0 3.8 3 0 0 3 3 3 0 ORF11CD3 domain Phage_sheath_1N PF17481.2 EFC39927.1 - 0.18 12.3 3.6 88 3.7 3.6 3.2 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain HAMP_N3 PF18575.1 EFC39927.1 - 0.28 10.8 4.4 51 3.5 0.1 3.4 3 0 0 3 3 3 0 HAMP N-terminal domain 3 PI3K_p85B PF02192.16 EFC39927.1 - 0.73 9.6 8.4 41 4.0 0.1 4.0 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain DUF4116 PF13475.6 EFC39928.1 - 9.6e-136 441.4 5.9 2.3e-15 56.1 0.0 11.3 4 2 10 15 15 15 15 Domain of unknown function (DUF4116) AfsA PF03756.13 EFC39928.1 - 0.0028 17.6 0.3 1.5 8.8 0.0 3.5 3 0 0 3 3 3 2 A-factor biosynthesis hotdog domain VWA_2 PF13519.6 EFC39928.1 - 0.069 13.8 0.1 0.33 11.6 0.1 2.2 1 0 0 1 1 1 0 von Willebrand factor type A domain EGF_2 PF07974.13 EFC39929.1 - 0.00054 20.3 7.3 0.00054 20.3 7.3 2.3 2 0 0 2 2 2 1 EGF-like domain NHL PF01436.21 EFC39929.1 - 0.0037 17.2 0.0 0.38 10.9 0.0 3.2 3 0 0 3 3 3 1 NHL repeat EGF PF00008.27 EFC39929.1 - 7.2 7.0 9.2 5.3 7.4 4.1 2.6 1 1 1 2 2 2 0 EGF-like domain hEGF PF12661.7 EFC39929.1 - 9.6 7.0 14.1 6.5 7.5 7.2 2.8 2 0 0 2 2 2 0 Human growth factor-like EGF NHL PF01436.21 EFC39930.1 - 1.3e-39 132.3 7.8 5.2e-05 23.1 0.0 10.8 11 0 0 11 11 11 9 NHL repeat SGL PF08450.12 EFC39930.1 - 6.4e-06 25.9 0.3 1.8 8.1 0.0 4.8 3 1 1 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC39930.1 - 0.56 10.4 8.0 25 5.2 0.0 5.0 6 0 0 6 6 6 0 Arylesterase 2OG-FeII_Oxy_3 PF13640.6 EFC39931.1 - 8.2e-08 33.0 0.0 1.7e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lipase_GDSL_2 PF13472.6 EFC39933.1 - 1.6e-10 41.7 0.0 1.8e-10 41.5 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFC39933.1 - 0.00015 21.8 0.0 0.00017 21.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Mito_carr PF00153.27 EFC39934.1 - 2.5e-44 149.1 3.6 6e-23 80.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein ThiF PF00899.21 EFC39935.1 - 0.082 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 ThiF family DUF4116 PF13475.6 EFC39937.1 - 6.2e-51 169.9 10.4 5.4e-17 61.3 0.0 7.5 4 3 4 8 8 8 6 Domain of unknown function (DUF4116) Herpes_heli_pri PF05774.11 EFC39937.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus helicase-primase complex component Pep1_7 PF17232.2 EFC39937.1 - 0.67 10.5 4.6 0.51 10.8 0.1 2.8 3 0 0 3 3 3 0 Elicitor peptide 1-7 Pescadillo_N PF06732.11 EFC39938.1 - 2.7e-88 296.1 7.1 2.7e-88 296.1 7.1 2.1 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 EFC39938.1 - 1e-06 29.0 3.0 1.1e-06 28.9 0.0 2.6 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PS_pyruv_trans PF04230.13 EFC39938.1 - 0.69 9.8 3.0 0.48 10.3 0.4 2.0 2 0 0 2 2 2 0 Polysaccharide pyruvyl transferase BCAS2 PF05700.11 EFC39939.1 - 3.5e-10 39.9 19.6 7.2e-09 35.6 16.7 2.4 2 1 0 2 2 2 1 Breast carcinoma amplified sequence 2 (BCAS2) Thioredoxin_8 PF13905.6 EFC39939.1 - 0.034 14.5 1.4 0.08 13.3 1.4 1.8 1 1 0 1 1 1 0 Thioredoxin-like Jnk-SapK_ap_N PF09744.9 EFC39939.1 - 0.91 9.7 26.0 0.11 12.7 1.7 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 EFC39939.1 - 1.8 7.9 6.7 3.2 7.0 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2681 PF10883.8 EFC39939.1 - 5.4 7.5 15.4 0.16 12.4 4.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) PGAP1 PF07819.13 EFC39940.1 - 2.7e-48 164.7 0.0 5.1e-48 163.8 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein DUF915 PF06028.11 EFC39940.1 - 0.00069 19.0 0.0 0.039 13.3 0.0 2.4 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 EFC39940.1 - 0.00087 18.9 0.0 0.002 17.7 0.0 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 EFC39940.1 - 0.0012 19.5 0.0 0.002 18.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EFC39940.1 - 0.021 14.7 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 EFC39940.1 - 0.071 12.4 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RhoGEF PF00621.20 EFC39941.1 - 0.7 10.1 8.1 0.58 10.4 1.5 2.9 2 1 0 2 2 2 0 RhoGEF domain AAA_33 PF13671.6 EFC39942.1 - 8.1e-20 71.4 0.0 7.5e-09 35.9 0.0 2.1 1 1 1 2 2 2 2 AAA domain KTI12 PF08433.10 EFC39942.1 - 5.8e-08 32.5 0.9 0.00025 20.6 0.0 2.1 1 1 1 2 2 2 2 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 EFC39942.1 - 2.3e-06 27.0 0.0 0.0016 17.8 0.0 2.1 1 1 1 2 2 2 2 Zeta toxin 6PF2K PF01591.18 EFC39942.1 - 6.9e-06 25.5 0.0 0.0046 16.3 0.0 2.1 1 1 0 2 2 2 2 6-phosphofructo-2-kinase AAA_18 PF13238.6 EFC39942.1 - 9.9e-06 26.1 0.3 0.00014 22.4 0.3 2.2 1 1 0 1 1 1 1 AAA domain tRNA_lig_kinase PF08303.11 EFC39942.1 - 0.001 19.2 0.7 0.0036 17.4 0.7 1.9 1 1 0 1 1 1 1 tRNA ligase kinase domain AAA_22 PF13401.6 EFC39942.1 - 0.0012 19.1 0.1 0.002 18.4 0.1 1.7 1 1 0 1 1 1 1 AAA domain Sushi_2 PF09014.10 EFC39942.1 - 0.0061 16.4 0.2 0.014 15.3 0.2 1.8 1 1 0 1 1 1 1 Beta-2-glycoprotein-1 fifth domain Viral_helicase1 PF01443.18 EFC39942.1 - 0.02 14.7 0.1 0.035 13.8 0.1 1.4 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase SKI PF01202.22 EFC39942.1 - 0.023 14.8 0.4 0.41 10.7 0.1 2.1 1 1 1 2 2 2 0 Shikimate kinase AAA_17 PF13207.6 EFC39942.1 - 0.044 14.2 0.1 0.14 12.6 0.0 1.8 1 1 1 2 2 2 0 AAA domain dNK PF01712.19 EFC39942.1 - 0.079 12.8 0.2 1.5 8.6 0.1 2.4 1 1 1 2 2 2 0 Deoxynucleoside kinase RNA_helicase PF00910.22 EFC39942.1 - 0.096 13.1 0.2 0.22 11.9 0.0 1.7 2 0 0 2 2 2 0 RNA helicase RCC1 PF00415.18 EFC39943.1 - 4.8e-10 39.9 0.3 0.0078 16.8 0.0 4.5 3 1 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC39943.1 - 1.9e-09 37.1 1.5 0.0001 22.0 0.1 2.8 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat TauE PF01925.19 EFC39944.1 - 1.8e-37 129.2 16.3 1e-20 74.4 9.0 2.1 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE Gly-zipper_Omp PF13488.6 EFC39944.1 - 0.056 13.5 0.1 0.056 13.5 0.1 3.4 4 0 0 4 4 4 0 Glycine zipper PRCH PF03967.13 EFC39944.1 - 0.21 11.8 0.0 0.45 10.7 0.0 1.5 1 0 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region PAP2 PF01569.21 EFC39944.1 - 0.24 11.2 3.3 2.2 8.1 1.7 2.6 2 0 0 2 2 2 0 PAP2 superfamily Alpha-2-MRAP_C PF06401.11 EFC39945.1 - 0.0072 16.3 4.3 0.0085 16.1 4.3 1.1 1 0 0 1 1 1 1 Alpha-2-macroglobulin RAP, C-terminal domain U62_UL91 PF17442.2 EFC39945.1 - 0.028 14.4 1.1 0.052 13.6 0.3 1.9 2 1 0 2 2 2 0 Functional domain of U62 and UL91 proteins DrrA_P4M PF14860.6 EFC39945.1 - 0.26 11.2 9.1 0.29 11.0 5.2 2.0 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Lipoprotein_20 PF13942.6 EFC39945.1 - 0.44 10.5 5.5 1.5 8.7 1.6 2.0 1 1 1 2 2 2 0 YfhG lipoprotein DUF1282 PF06930.12 EFC39946.1 - 2.2 8.0 23.1 0.16 11.7 3.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1282) RNA_ligase PF09414.10 EFC39947.1 - 1.9e-24 86.8 1.4 1.9e-24 86.8 1.4 1.5 2 0 0 2 2 2 1 RNA ligase T4_Rnl2_C PF18043.1 EFC39947.1 - 9.2e-24 83.4 0.7 9.2e-24 83.4 0.7 2.1 2 0 0 2 2 2 1 T4 RNA ligase 2 C-terminal Trehalase PF01204.18 EFC39947.1 - 0.0078 15.1 0.2 0.011 14.6 0.2 1.4 1 0 0 1 1 1 1 Trehalase DUF3437 PF11919.8 EFC39947.1 - 0.05 13.5 0.0 0.33 10.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) DUF2286 PF10051.9 EFC39947.1 - 0.18 11.6 4.0 0.22 11.3 2.6 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2286) NmrA PF05368.13 EFC39948.1 - 3.6e-08 33.3 0.0 4.6e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 EFC39948.1 - 8e-05 22.9 0.0 0.00017 21.9 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 EFC39948.1 - 0.00065 19.6 0.0 0.00096 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 EFC39948.1 - 0.0011 19.1 0.0 0.011 15.9 0.0 2.2 1 1 1 2 2 2 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 EFC39948.1 - 0.0053 15.8 0.1 0.01 14.9 0.1 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC39948.1 - 0.17 11.0 0.0 0.43 9.7 0.0 1.6 2 0 0 2 2 2 0 Male sterility protein Pox_A_type_inc PF04508.12 EFC39948.1 - 0.39 10.7 2.5 1.1 9.2 0.7 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Ras PF00071.22 EFC39949.1 - 2.3e-23 82.6 0.0 4.1e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC39949.1 - 2.6e-14 53.5 0.0 7.9e-14 51.9 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC39949.1 - 1.3e-08 34.5 0.0 2.5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 EFC39949.1 - 0.00046 20.0 0.0 0.001 18.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC39949.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 F-box-like Hist_deacetyl PF00850.19 EFC39949.1 - 0.38 10.2 1.8 4.6 6.6 1.8 2.2 1 1 0 1 1 1 0 Histone deacetylase domain SH3_3 PF08239.11 EFC39950.1 - 1.6e-09 37.9 1.8 1.1e-08 35.2 0.1 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_4 PF06347.13 EFC39950.1 - 0.036 13.9 0.1 0.11 12.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial SH3 domain Ins145_P3_rec PF08709.11 EFC39952.1 - 1.7e-26 92.7 7.0 2.8e-25 88.8 4.8 3.5 3 1 0 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor RYDR_ITPR PF01365.21 EFC39952.1 - 3.1e-25 88.8 12.8 2e-16 60.1 0.5 4.2 3 1 0 3 3 3 2 RIH domain RIH_assoc PF08454.11 EFC39952.1 - 3.2e-22 78.3 0.5 3.2e-22 78.3 0.5 5.2 6 0 0 6 6 6 1 RyR and IP3R Homology associated MIR PF02815.19 EFC39952.1 - 1e-11 45.0 12.2 4e-10 39.8 0.0 3.4 2 1 1 3 3 3 2 MIR domain Ion_trans PF00520.31 EFC39952.1 - 1.2e-05 24.7 26.6 4e-05 23.0 26.6 2.0 1 1 0 1 1 1 1 Ion transport protein SPT6_acidic PF14632.6 EFC39953.1 - 0.084 13.5 5.2 0.6 10.7 1.7 2.3 2 0 0 2 2 2 0 Acidic N-terminal SPT6 tRNA-synt_2c PF01411.19 EFC39954.1 - 4.4e-05 22.2 0.0 7.7e-05 21.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFC39954.1 - 0.00012 22.0 0.1 0.00029 20.9 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain baeRF_family7 PF18849.1 EFC39954.1 - 0.0075 16.5 0.8 1.1 9.5 0.3 2.3 2 0 0 2 2 2 2 Bacterial archaeo-eukaryotic release factor family 7 TSNAXIP1_N PF15739.5 EFC39955.1 - 6.3e-06 26.5 5.4 6.3e-06 26.5 5.4 4.7 4 1 0 4 4 4 1 Translin-associated factor X-interacting N-terminus Peptidase_S24 PF00717.23 EFC39957.1 - 5.3e-11 42.3 0.0 7.8e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like TPR_1 PF00515.28 EFC39959.1 - 2.6e-08 33.3 12.1 0.037 13.9 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC39959.1 - 3.2e-05 24.1 3.3 0.02 15.2 0.2 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC39959.1 - 0.0064 16.5 16.6 2.2 8.6 0.1 5.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC39959.1 - 0.036 14.3 10.8 23 5.5 0.0 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC39959.1 - 0.081 12.6 4.6 0.71 9.6 0.7 3.6 4 0 0 4 4 4 0 TPR repeat TPR_17 PF13431.6 EFC39959.1 - 0.094 13.1 1.9 11 6.6 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat PARP PF00644.20 EFC39960.1 - 1.6e-13 50.7 0.1 3.6e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ARTD15_N PF18084.1 EFC39960.1 - 1.7e-08 34.6 0.0 3.9e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 ARTD15 N-terminal domain Rep_2 PF01719.17 EFC39960.1 - 0.048 13.5 2.1 2.5 7.9 0.1 3.1 2 1 1 3 3 3 0 Plasmid replication protein Glyco_hydro_38N PF01074.22 EFC39960.1 - 0.058 12.8 1.8 1.4 8.2 0.3 2.4 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 N-terminal domain Trypan_PARP PF05887.11 EFC39961.1 - 3.8e-07 30.1 114.7 0.022 14.7 37.2 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) Antistasin PF02822.14 EFC39962.1 - 2.1e-18 66.6 46.1 4.4e-07 30.4 9.9 3.4 3 0 0 3 3 3 3 Antistasin family PRCC PF10253.9 EFC39962.1 - 0.28 11.9 6.3 0.58 10.9 6.3 1.5 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF2052 PF09747.9 EFC39964.1 - 4.7 7.3 70.6 0.74 9.9 23.0 3.2 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) C2 PF00168.30 EFC39965.1 - 1.7e-19 70.0 0.4 3e-19 69.2 0.4 1.4 1 0 0 1 1 1 1 C2 domain DOCK-C2 PF14429.6 EFC39965.1 - 0.021 14.6 1.2 0.036 13.9 0.4 1.7 1 1 1 2 2 2 0 C2 domain in Dock180 and Zizimin proteins DUF393 PF04134.12 EFC39967.1 - 8.7e-29 101.2 0.0 1.2e-28 100.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF393 Guanylate_cyc PF00211.20 EFC39969.1 - 2.8e-51 173.7 0.1 5.5e-51 172.8 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC39969.1 - 1.7e-14 53.9 0.1 7.7e-14 51.8 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC39969.1 - 5.2e-09 36.1 0.0 1.3e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC39969.1 - 0.012 15.8 0.0 0.025 14.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 EFC39969.1 - 0.012 15.6 0.0 0.043 13.9 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_10 PF13596.6 EFC39969.1 - 0.025 15.1 0.3 0.15 12.7 0.0 2.5 2 0 0 2 2 2 0 PAS domain DUF3084 PF11283.8 EFC39969.1 - 0.11 12.5 0.0 5.3 7.1 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3084) PAS_2 PF08446.11 EFC39969.1 - 0.12 13.0 0.0 0.85 10.3 0.0 2.5 2 0 0 2 2 2 0 PAS fold DEAD PF00270.29 EFC39970.1 - 4.7e-19 68.8 0.1 4.1e-18 65.8 0.0 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC39970.1 - 5.6e-12 46.0 0.1 5.6e-12 46.0 0.1 3.3 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC39970.1 - 0.00072 19.9 0.0 0.0064 16.8 0.0 2.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DNA_pack_N PF02500.15 EFC39970.1 - 0.0012 18.8 1.4 1.2 9.0 0.0 3.0 2 0 0 2 2 2 2 Probable DNA packing protein, N-terminus DUF2075 PF09848.9 EFC39970.1 - 0.027 13.7 0.2 0.35 10.0 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Rep_fac-A_3 PF08661.11 EFC39970.1 - 0.26 11.7 1.7 4.6 7.7 0.0 3.2 3 0 0 3 3 3 0 Replication factor A protein 3 Chalcone_3 PF16036.5 EFC39970.1 - 0.26 11.4 1.7 0.97 9.5 1.1 2.3 2 0 0 2 2 2 0 Chalcone isomerase-like F-box-like PF12937.7 EFC39971.1 - 2.8e-05 23.9 0.0 6.4e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFC39971.1 - 8.6e-05 22.8 52.1 0.13 12.7 3.3 9.2 6 4 3 9 9 9 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC39971.1 - 0.00067 19.5 0.1 0.00067 19.5 0.1 10.1 12 0 0 12 12 12 4 Leucine Rich repeat LRR_8 PF13855.6 EFC39971.1 - 0.0018 18.0 0.9 0.0018 18.0 0.9 8.7 7 3 1 8 8 8 2 Leucine rich repeat FTH PF01827.27 EFC39971.1 - 0.003 17.4 10.5 0.41 10.4 0.0 4.4 3 1 1 4 4 4 2 FTH domain UPF0061 PF02696.14 EFC39972.1 - 9.1e-115 384.1 7.5 9.4e-113 377.4 7.5 2.1 1 1 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Ank_4 PF13637.6 EFC39973.1 - 3.7e-09 36.9 0.0 5.3e-05 23.7 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC39973.1 - 2.6e-08 34.3 1.1 0.0007 20.1 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC39973.1 - 1.6e-06 28.0 0.1 1.3 9.8 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFC39973.1 - 0.071 13.4 0.1 39 4.7 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeats (many copies) dCache_1 PF02743.18 EFC39974.1 - 1.8e-05 24.7 4.6 4.9e-05 23.2 4.5 1.8 1 1 0 1 1 1 1 Cache domain Guanylate_cyc PF00211.20 EFC39974.1 - 0.0035 17.0 0.0 0.0074 15.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DSPc PF00782.20 EFC39975.1 - 5.9e-19 68.2 1.2 1.3e-17 63.8 0.4 3.1 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC39975.1 - 0.0062 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC39975.1 - 0.0079 15.9 0.2 0.52 10.0 0.0 2.4 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Init_tRNA_PT PF04179.12 EFC39975.1 - 0.015 15.6 0.0 0.078 13.3 0.0 2.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFC39975.1 - 0.017 15.2 0.1 0.13 12.3 0.0 2.4 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EFC39975.1 - 0.042 13.4 0.1 0.11 12.1 0.1 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family TauE PF01925.19 EFC39976.1 - 1.8e-29 103.1 31.0 1.1e-15 57.9 2.7 2.6 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE SCAMP PF04144.13 EFC39977.1 - 1.7e-25 90.3 25.7 2.1e-25 90.0 25.7 1.1 1 0 0 1 1 1 1 SCAMP family Topoisom_bac PF01131.20 EFC39978.1 - 1.2e-110 370.4 0.0 1.7e-110 369.9 0.0 1.2 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 EFC39978.1 - 2.1e-17 63.2 0.0 6.2e-17 61.7 0.0 1.8 2 0 0 2 2 2 1 Toprim domain zf-C4_Topoisom PF01396.19 EFC39978.1 - 8.8e-10 38.2 1.8 8.8e-10 38.2 1.8 4.2 6 0 0 6 6 6 2 Topoisomerase DNA binding C4 zinc finger zf-GRF PF06839.12 EFC39978.1 - 4e-08 33.2 7.5 4e-08 33.2 7.5 3.7 3 0 0 3 3 3 1 GRF zinc finger DPM3 PF08285.11 EFC39979.1 - 6.4 7.0 14.3 26 5.1 7.4 3.1 2 1 1 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Glyco_hydro_1 PF00232.18 EFC39980.1 - 0.024 13.1 0.3 0.027 12.9 0.3 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Glyco_hydro_31 PF01055.26 EFC39982.1 - 2.1e-50 172.2 7.8 3.2e-50 171.6 7.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 C2 PF00168.30 EFC39983.1 - 1.5e-16 60.6 0.1 6.8e-16 58.4 0.0 2.1 2 1 1 3 3 3 1 C2 domain Shisa PF13908.6 EFC39984.1 - 0.013 15.8 4.7 0.51 10.6 0.8 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator FtsX PF02687.21 EFC39984.1 - 0.034 14.6 3.7 5.9 7.4 0.9 2.9 2 1 0 2 2 2 0 FtsX-like permease family TPR_1 PF00515.28 EFC39984.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat SCF PF02404.15 EFC39984.1 - 0.25 10.7 6.5 0.82 9.0 0.2 2.6 2 1 0 2 2 2 0 Stem cell factor TerC PF03741.16 EFC39984.1 - 0.7 9.5 6.0 0.1 12.3 1.2 1.9 2 0 0 2 2 2 0 Integral membrane protein TerC family RCC1_2 PF13540.6 EFC39985.1 - 0.00024 20.8 1.5 0.072 12.9 0.0 4.1 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC39985.1 - 0.00051 20.6 0.0 3.2 8.4 0.0 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Y1_Tnp PF01797.16 EFC39985.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Transposase IS200 like LRR_6 PF13516.6 EFC39986.1 - 8.4e-17 59.7 20.1 3e-05 23.7 0.1 8.5 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 EFC39986.1 - 1.6e-10 41.1 32.3 0.0012 19.2 1.3 5.7 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC39986.1 - 8.5e-07 28.7 31.7 0.056 13.2 9.5 6.7 2 1 3 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 EFC39986.1 - 0.00063 19.9 23.5 1.7 9.5 0.1 7.3 7 3 0 7 7 7 3 Leucine Rich Repeat EGF_2 PF07974.13 EFC39987.1 - 1.6e-05 25.2 27.6 0.0084 16.5 12.2 2.7 2 0 0 2 2 2 2 EGF-like domain GPS PF01825.21 EFC39987.1 - 0.00048 20.6 0.0 0.00048 20.6 0.0 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif hEGF PF12661.7 EFC39987.1 - 0.059 14.0 20.5 0.63 10.8 7.7 3.4 2 0 0 2 2 2 0 Human growth factor-like EGF EGF PF00008.27 EFC39987.1 - 9.3 6.7 17.9 7.1 7.0 7.4 2.7 2 0 0 2 2 2 0 EGF-like domain Pkinase PF00069.25 EFC39988.1 - 1.2e-40 139.6 0.5 8.7e-40 136.7 0.5 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC39988.1 - 2.3e-11 43.5 0.7 1.9e-10 40.5 0.7 2.6 1 1 0 1 1 1 1 Protein tyrosine kinase 7tm_4 PF13853.6 EFC39988.1 - 0.049 13.4 0.1 0.098 12.4 0.1 1.5 1 1 0 1 1 1 0 Olfactory receptor LRR_4 PF12799.7 EFC39989.1 - 1.9e-06 28.1 25.2 0.079 13.4 0.4 7.8 6 3 3 9 9 9 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC39989.1 - 0.00039 20.3 0.4 0.00086 19.1 0.4 1.6 1 0 0 1 1 1 1 F-box-like RAMP PF04901.13 EFC39989.1 - 0.00082 19.4 0.6 0.022 14.8 0.4 2.5 2 0 0 2 2 2 1 Receptor activity modifying family F-box PF00646.33 EFC39989.1 - 0.03 14.2 0.6 0.11 12.4 0.6 2.1 1 0 0 1 1 1 0 F-box domain Glyco_transf_8 PF01501.20 EFC39990.1 - 5.5e-11 42.5 0.7 6.4e-09 35.7 0.7 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 zf-GRF PF06839.12 EFC39991.1 - 2.8e-05 24.1 8.8 0.009 16.1 1.8 2.9 2 0 0 2 2 2 2 GRF zinc finger F-box PF00646.33 EFC39991.1 - 2.9e-05 23.8 0.0 8.3e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC39991.1 - 5.7e-05 22.9 1.0 9.3e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 F-box-like HSP20 PF00011.21 EFC39991.1 - 0.0024 18.0 0.1 0.0064 16.6 0.1 1.7 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC39991.1 - 0.0032 17.0 0.0 0.0065 16.0 0.0 1.5 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFC39991.1 - 0.033 15.2 0.7 0.087 13.9 0.7 1.7 1 0 0 1 1 1 0 CS domain Mss4 PF04421.13 EFC39993.1 - 0.022 14.9 2.2 0.048 13.8 1.3 2.1 1 1 0 1 1 1 0 Mss4 protein DUF4685 PF15737.5 EFC39993.1 - 0.035 14.6 1.1 0.035 14.6 1.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) BCOR PF15808.5 EFC39993.1 - 0.039 14.2 4.6 0.052 13.8 4.6 1.2 1 0 0 1 1 1 0 BCL-6 co-repressor, non-ankyrin-repeat region Glyoxalase PF00903.25 EFC39994.1 - 8.8e-13 48.6 0.0 2.2e-12 47.3 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EFC39994.1 - 3.8e-06 26.8 0.0 5.1e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EFC39994.1 - 6.1e-05 23.8 0.0 8.5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain DUF962 PF06127.11 EFC39995.1 - 2.4e-22 78.8 0.0 4.4e-22 78.0 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Insulin_TMD PF17870.1 EFC39995.1 - 0.089 12.9 7.8 0.39 10.8 3.2 3.0 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment EPL1 PF10513.9 EFC39996.1 - 5.4e-09 36.6 1.8 5.4e-09 36.6 1.8 6.9 3 2 1 4 4 4 1 Enhancer of polycomb-like ADH_N PF08240.12 EFC39997.1 - 2.9e-18 65.8 2.1 5e-18 65.0 2.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC39997.1 - 2.1e-16 60.1 0.0 4e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC39997.1 - 3.6e-08 34.5 0.0 6.3e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFC39997.1 - 7.7e-06 25.4 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EFC39997.1 - 0.0016 17.8 0.0 0.004 16.5 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFC39997.1 - 0.076 13.2 0.1 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short PF00106.25 EFC39998.1 - 6.4e-31 107.3 0.8 1.5e-25 89.8 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC39998.1 - 3.7e-23 82.3 0.0 5.4e-18 65.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC39998.1 - 0.00067 19.6 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 KR domain ERp29 PF07749.12 EFC39998.1 - 0.1 13.5 0.9 9.9 7.1 0.1 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain SNF PF00209.18 EFC39999.1 - 3.2e-105 352.8 44.7 2.8e-70 237.5 20.1 3.1 2 1 1 3 3 3 3 Sodium:neurotransmitter symporter family UCMA PF17085.5 EFC39999.1 - 1.7 8.7 5.9 4.3 7.3 5.9 1.7 1 0 0 1 1 1 0 Unique cartilage matrix associated protein Rhodanese PF00581.20 EFC40000.1 - 4.8e-26 91.4 0.0 1.2e-12 48.3 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Pkinase PF00069.25 EFC40001.1 - 4.6e-19 68.8 0.2 1.6e-18 67.1 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40001.1 - 3.9e-15 55.8 0.0 9.8e-15 54.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase SPRY PF00622.28 EFC40002.1 - 0.0023 18.0 0.1 0.0039 17.3 0.1 1.3 1 0 0 1 1 1 1 SPRY domain CBM39 PF15886.5 EFC40002.1 - 0.034 14.1 0.3 1 9.3 0.0 2.3 2 0 0 2 2 2 0 Carbohydrate binding domain (family 32) DEAD PF00270.29 EFC40005.1 - 7.7e-22 77.9 0.2 9.1e-22 77.7 0.2 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 EFC40005.1 - 0.0051 16.2 0.2 0.02 14.2 0.2 1.8 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit Ras PF00071.22 EFC40006.1 - 2.3e-24 85.8 0.1 3.7e-24 85.1 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40006.1 - 1.3e-14 54.4 0.5 4.7e-14 52.6 0.2 2.0 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40006.1 - 3e-11 43.1 0.1 2.2e-10 40.2 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family F-box PF00646.33 EFC40006.1 - 1.1e-06 28.4 0.0 3.2e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 EFC40006.1 - 1.2e-05 24.8 0.4 2.3e-05 23.9 0.4 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region F-box-like PF12937.7 EFC40006.1 - 5e-05 23.1 0.0 0.00017 21.4 0.0 1.9 2 0 0 2 2 2 1 F-box-like PRANC PF09372.10 EFC40006.1 - 0.011 16.0 1.7 0.045 14.1 1.7 2.1 1 0 0 1 1 1 0 PRANC domain F-box_4 PF15966.5 EFC40006.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 F-box Ribosomal_L28e PF01778.17 EFC40007.1 - 1e-15 58.5 3.3 1.2e-15 58.3 3.3 1.0 1 0 0 1 1 1 1 Ribosomal L28e protein family H-kinase_dim PF02895.14 EFC40007.1 - 0.1 13.0 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain Peptidase_S49 PF01343.18 EFC40008.1 - 4.9e-65 218.2 0.1 2.1e-39 135.0 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 SDH_sah PF01972.16 EFC40008.1 - 1.4e-05 24.2 0.0 0.00022 20.3 0.0 2.3 2 0 0 2 2 2 1 Serine dehydrogenase proteinase CLP_protease PF00574.23 EFC40008.1 - 0.00043 20.2 0.0 0.0019 18.1 0.0 2.0 2 0 0 2 2 2 1 Clp protease SAC3 PF12209.8 EFC40008.1 - 0.0014 18.8 1.9 0.077 13.2 0.3 3.1 2 0 0 2 2 2 1 Leucine permease transcriptional regulator helical domain THF_DHG_CYH PF00763.23 EFC40008.1 - 0.012 15.9 0.1 1.2 9.4 0.0 2.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain BBS2_C PF14782.6 EFC40009.1 - 0.026 13.3 0.5 0.038 12.8 0.0 1.4 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal Trimer_CC PF08954.11 EFC40009.1 - 0.054 13.1 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 Trimerisation motif Hepar_II_III PF07940.13 EFC40010.1 - 3.4e-05 23.6 0.1 0.0015 18.2 0.1 2.4 2 1 0 2 2 2 2 Heparinase II/III-like protein DLH PF01738.18 EFC40011.1 - 1.5e-23 83.5 0.0 1.9e-23 83.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 EFC40011.1 - 8.4e-05 22.3 0.0 0.0016 18.1 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC40011.1 - 0.0044 17.7 0.0 0.0049 17.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC40011.1 - 0.014 14.6 0.0 2.7 7.2 0.0 2.1 1 1 1 2 2 2 0 Serine aminopeptidase, S33 LRR_6 PF13516.6 EFC40012.1 - 3.9e-74 238.5 15.9 1e-05 25.1 0.1 15.0 15 0 0 15 15 15 14 Leucine Rich repeat LRR_8 PF13855.6 EFC40012.1 - 2.6e-46 155.2 22.2 6.7e-10 38.6 0.0 6.2 2 2 4 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC40012.1 - 1.4e-44 149.3 11.1 2.9e-05 24.3 0.0 8.5 2 1 11 13 13 13 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40012.1 - 8.8e-24 80.4 0.0 14 6.7 0.0 13.9 15 0 0 15 15 15 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC40012.1 - 1.6e-07 31.0 0.3 0.44 10.0 0.0 3.8 1 1 3 5 5 5 3 Leucine-rich repeat CLU_N PF15044.6 EFC40012.1 - 0.00026 21.3 9.3 9.4 6.7 0.1 7.8 4 3 5 9 9 9 1 Mitochondrial function, CLU-N-term RHH_3 PF12651.7 EFC40012.1 - 0.00038 20.3 0.1 52 3.9 0.1 5.5 3 2 2 5 5 5 0 Ribbon-helix-helix domain DUF4368 PF14287.6 EFC40012.1 - 0.0032 17.8 10.9 18 5.7 0.0 6.4 5 2 2 7 7 7 1 Domain of unknown function (DUF4368) ApoB100_C PF12491.8 EFC40012.1 - 0.12 12.3 12.1 63 3.6 0.0 8.2 6 3 6 12 12 12 0 Apolipoprotein B100 C terminal FA_desaturase PF00487.24 EFC40013.1 - 1.7e-25 90.3 13.6 1.7e-25 90.3 13.6 1.5 1 1 1 2 2 2 2 Fatty acid desaturase Lipid_DES PF08557.10 EFC40013.1 - 6.1e-17 60.8 1.8 1.1e-16 60.1 1.8 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Gly_transf_sug PF04488.15 EFC40014.1 - 1.7e-10 41.4 2.8 2.7e-10 40.7 0.4 2.4 1 1 1 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif PDH_E1_M PF17831.1 EFC40014.1 - 0.018 14.6 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 Pyruvate dehydrogenase E1 component middle domain TcdA_TcdB PF12919.7 EFC40014.1 - 0.027 13.8 0.9 0.052 12.8 0.0 1.8 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain RGS PF00615.19 EFC40015.1 - 1.5e-08 34.9 0.1 3.6e-08 33.7 0.1 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC40015.1 - 0.026 14.2 1.6 0.039 13.7 0.0 1.9 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain MLANA PF14991.6 EFC40015.1 - 3.3 8.0 5.6 2 8.7 0.1 3.1 3 0 0 3 3 3 0 Protein melan-A Pro-kuma_activ PF09286.11 EFC40019.1 - 3.1e-18 66.4 0.1 1.8e-17 63.9 0.2 2.1 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFC40019.1 - 1.6e-05 24.3 0.4 2.5e-05 23.7 0.4 1.2 1 0 0 1 1 1 1 Subtilase family C2 PF00168.30 EFC40020.1 - 1.4e-20 73.5 0.1 3.5e-20 72.2 0.1 1.7 1 0 0 1 1 1 1 C2 domain YbjQ_1 PF01906.17 EFC40020.1 - 2.2e-05 25.0 0.7 0.13 12.9 0.0 3.7 3 1 1 4 4 4 2 Putative heavy-metal-binding DUF5497 PF17601.2 EFC40020.1 - 0.089 13.1 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5497) Sin_N PF04801.13 EFC40021.1 - 1.7e-105 353.7 5.6 1.7e-105 353.7 5.6 1.6 2 0 0 2 2 2 1 Sin-like protein conserved region Prefoldin_2 PF01920.20 EFC40022.1 - 7.3e-12 45.2 3.1 7.3e-12 45.2 3.1 1.6 1 1 1 2 2 2 1 Prefoldin subunit Pyr_redox_2 PF07992.14 EFC40023.1 - 1.9e-47 161.9 0.0 2.7e-47 161.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 EFC40023.1 - 9.3e-21 74.5 6.5 1.1e-09 38.8 0.0 3.1 2 1 1 3 3 3 2 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 EFC40023.1 - 7.9e-12 45.6 0.1 2.7e-09 37.5 0.0 2.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC40023.1 - 3.2e-09 36.5 3.3 9.9e-09 34.9 0.6 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC40023.1 - 2.7e-05 24.2 0.1 0.068 13.2 0.0 3.6 2 1 0 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.14 EFC40023.1 - 0.0011 17.8 0.0 1.7 7.3 0.0 3.1 3 1 0 3 3 3 2 HI0933-like protein Reductase_C PF14759.6 EFC40023.1 - 0.0018 18.8 0.1 3.3 8.3 0.0 2.9 2 1 1 3 3 3 2 Reductase C-terminal Amino_oxidase PF01593.24 EFC40023.1 - 0.0041 16.5 0.1 0.013 14.9 0.1 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase OxoGdeHyase_C PF16870.5 EFC40023.1 - 0.025 14.3 0.1 0.085 12.5 0.1 1.9 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase C-terminal DAO PF01266.24 EFC40023.1 - 0.046 13.3 0.1 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF2201 PF09967.9 EFC40023.1 - 0.088 13.0 0.0 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 VWA-like domain (DUF2201) SpoIIE PF07228.12 EFC40025.1 - 2.3e-06 27.6 0.0 5.5e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EFC40025.1 - 0.022 14.4 0.0 0.98 9.0 0.0 2.2 2 0 0 2 2 2 0 Protein phosphatase 2C PP2C_2 PF13672.6 EFC40025.1 - 0.052 13.2 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C DUF3573 PF12097.8 EFC40025.1 - 0.072 11.9 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Ribosomal_S9 PF00380.19 EFC40026.1 - 2.9e-40 137.6 0.0 1.4e-39 135.4 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein S9/S16 SRP1_TIP1 PF00660.17 EFC40026.1 - 0.021 14.9 0.4 7.8 6.6 0.0 3.0 2 0 0 2 2 2 0 Seripauperin and TIP1 family Fibrillarin PF01269.17 EFC40027.1 - 1.6e-101 338.2 0.0 1.9e-101 337.9 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 EFC40027.1 - 0.0035 17.1 0.0 0.0054 16.4 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 EFC40027.1 - 0.063 13.0 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EFC40027.1 - 0.15 12.2 0.0 0.34 11.0 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase NUDIX PF00293.28 EFC40028.1 - 2.8e-10 40.3 0.2 4.8e-10 39.6 0.2 1.4 1 0 0 1 1 1 1 NUDIX domain DEAD PF00270.29 EFC40029.1 - 1.7e-23 83.3 0.0 2.2e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase TniB PF05621.11 EFC40029.1 - 0.0055 16.1 0.0 0.014 14.9 0.0 1.7 1 1 0 1 1 1 1 Bacterial TniB protein AAA_22 PF13401.6 EFC40029.1 - 0.099 12.9 0.1 0.37 11.1 0.0 1.9 2 1 1 3 3 3 0 AAA domain FAD_binding_3 PF01494.19 EFC40030.1 - 1.4e-07 31.1 0.0 2.1e-06 27.2 0.0 2.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC40030.1 - 9.9e-07 28.3 0.1 0.00089 18.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC40030.1 - 2.9e-06 27.1 0.0 0.00062 19.4 0.0 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFC40030.1 - 0.00041 20.9 0.4 0.012 16.2 0.0 3.1 2 2 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFC40030.1 - 0.0018 17.2 0.1 3.8 6.3 0.0 3.1 3 0 0 3 3 3 2 Tryptophan halogenase NAD_binding_8 PF13450.6 EFC40030.1 - 0.0065 16.7 0.0 0.013 15.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DUF1188 PF06690.11 EFC40030.1 - 0.011 15.3 0.2 0.059 12.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) HI0933_like PF03486.14 EFC40030.1 - 0.02 13.6 0.1 0.28 9.9 0.0 2.4 2 0 0 2 2 2 0 HI0933-like protein Peptidase_M28 PF04389.17 EFC40031.1 - 1.7e-08 34.4 0.0 3.2e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 EFC40031.1 - 1.6e-05 24.8 0.0 3.3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 PA domain PAS PF00989.25 EFC40033.1 - 5.8e-24 84.3 0.0 7.7e-13 48.4 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC40033.1 - 4.1e-23 81.6 0.3 9.2e-12 45.1 0.0 2.8 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 EFC40033.1 - 1.4e-11 44.6 0.0 3.5e-05 24.0 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 EFC40033.1 - 9e-10 38.4 0.0 0.0001 22.2 0.0 2.3 2 0 0 2 2 2 2 PAS domain PB1 PF00564.24 EFC40033.1 - 3e-06 27.0 0.2 1e-05 25.4 0.1 1.9 2 0 0 2 2 2 1 PB1 domain PAS_3 PF08447.12 EFC40033.1 - 6.1e-05 23.2 0.0 0.65 10.3 0.0 2.6 2 0 0 2 2 2 2 PAS fold Vitellogenin_N PF01347.22 EFC40033.1 - 0.01 14.3 0.2 0.017 13.5 0.2 1.3 1 0 0 1 1 1 0 Lipoprotein amino terminal region SAM_1 PF00536.30 EFC40033.1 - 0.15 12.5 0.2 0.35 11.3 0.2 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) NINJA_B PF16136.5 EFC40033.1 - 0.34 11.3 2.8 3.6 8.0 0.0 2.8 3 0 0 3 3 3 0 Putative nuclear localisation signal DUF3720 PF12517.8 EFC40033.1 - 8.8 7.3 8.4 0.62 11.0 3.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3720) Complex1_LYR PF05347.15 EFC40034.1 - 0.00099 19.1 0.0 0.0026 17.8 0.0 1.8 1 1 0 1 1 1 1 Complex 1 protein (LYR family) F-box PF00646.33 EFC40035.1 - 0.087 12.7 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC40035.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.6 1 0 0 1 1 1 0 F-box-like DUF1082 PF06449.11 EFC40035.1 - 0.26 11.2 1.6 0.48 10.3 0.3 2.1 2 0 0 2 2 2 0 Mitochondrial domain of unknown function (DUF1082) Sas10_Utp3 PF04000.15 EFC40036.1 - 4.7e-20 72.0 3.4 4.7e-20 72.0 3.4 4.0 4 1 0 4 4 4 1 Sas10/Utp3/C1D family Sas10 PF09368.10 EFC40036.1 - 4.9e-13 49.3 7.3 4.9e-13 49.3 7.3 4.8 4 1 1 5 5 5 1 Sas10 C-terminal domain zf-CCCH_7 PF18586.1 EFC40036.1 - 2 8.8 4.6 7.2 7.0 0.4 3.1 2 1 1 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Ribosomal_S3Ae PF01015.18 EFC40037.1 - 6.9e-33 113.9 4.3 8.7e-33 113.6 4.3 1.2 1 0 0 1 1 1 1 Ribosomal S3Ae family Cytokin_check_N PF10407.9 EFC40037.1 - 0.11 12.5 1.7 0.16 11.9 0.2 2.1 2 0 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus F-box-like PF12937.7 EFC40037.1 - 0.16 11.9 0.1 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 F-box-like DUF3836 PF12930.7 EFC40037.1 - 0.41 10.4 7.5 0.72 9.6 1.7 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF3836) Keratin_assoc PF09775.9 EFC40038.1 - 5.6e-22 77.8 9.8 1e-21 76.9 9.8 1.4 1 1 0 1 1 1 1 Keratinocyte-associated protein 2 Dehyd-heme_bind PF09098.10 EFC40039.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding DDA1 PF10172.9 EFC40041.1 - 0.0002 21.5 3.7 0.0002 21.5 3.7 2.7 2 1 0 2 2 2 1 Det1 complexing ubiquitin ligase Ank_2 PF12796.7 EFC40043.1 - 6.7e-14 52.2 0.0 1.3e-07 32.1 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC40043.1 - 1.3e-11 43.6 0.3 0.032 14.8 0.0 5.7 5 1 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFC40043.1 - 1.6e-06 28.6 0.0 0.0021 18.6 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC40043.1 - 1.5e-05 25.1 0.0 0.019 15.2 0.0 3.9 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC40043.1 - 6e-05 23.3 0.0 0.022 15.2 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Fibrinogen_C PF00147.18 EFC40044.1 - 2.7e-06 27.3 0.0 5.7e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Syntaxin-6_N PF09177.11 EFC40044.1 - 0.0062 17.1 0.2 0.012 16.1 0.2 1.4 1 0 0 1 1 1 1 Syntaxin 6, N-terminal DUF1018 PF06252.12 EFC40044.1 - 0.028 15.4 0.0 0.047 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) HATPase_c PF02518.26 EFC40046.1 - 4.4e-19 69.0 0.2 2e-18 66.9 0.0 2.2 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC40046.1 - 1.4e-18 67.1 1.1 1.4e-18 67.1 1.1 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFC40046.1 - 2.3e-11 43.6 0.9 7.8e-11 41.9 0.7 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain RCC1_2 PF13540.6 EFC40047.1 - 7.7e-05 22.4 0.9 0.53 10.2 0.0 3.7 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC40047.1 - 0.0082 16.7 2.1 7.1 7.3 0.1 4.1 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Ras PF00071.22 EFC40049.1 - 9.9e-45 152.0 0.2 4.9e-44 149.8 0.0 2.0 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC40049.1 - 8.4e-20 71.2 0.2 2.9e-19 69.4 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC40049.1 - 2.4e-11 43.6 0.0 8.2e-11 41.8 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC40049.1 - 1.2e-09 37.8 0.0 2.3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC40049.1 - 0.00057 19.9 0.0 0.0013 18.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC40049.1 - 0.00087 18.7 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region CRISPR_Cas9_WED PF18061.1 EFC40049.1 - 0.03 14.4 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 CRISPR-Cas9 WED domain DUF4763 PF15960.5 EFC40051.1 - 0.042 13.1 0.4 6.7 5.9 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) UCR_14kD PF02271.16 EFC40052.1 - 1.2e-27 95.8 0.9 1.8e-27 95.3 0.9 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit RCC1_2 PF13540.6 EFC40053.1 - 2.2e-17 62.4 6.8 2.7e-06 27.0 0.1 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC40053.1 - 2.3e-14 53.7 0.5 0.02 15.5 0.0 5.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Phytochelatin PF05023.14 EFC40054.1 - 8.6e-92 306.2 0.0 1.4e-91 305.5 0.0 1.4 1 0 0 1 1 1 1 Phytochelatin synthase DUF3638 PF12340.8 EFC40055.1 - 5e-30 104.5 0.1 1.3e-29 103.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EFC40055.1 - 5.7e-16 57.6 0.0 1.2e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) DUF3638 PF12340.8 EFC40056.1 - 4.2e-13 49.2 0.4 1.2e-12 47.7 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) AAA_17 PF13207.6 EFC40056.1 - 0.12 12.8 0.1 0.68 10.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain pRN1_helical PF13010.6 EFC40057.1 - 0.5 10.3 3.8 6 6.8 0.6 2.7 2 0 0 2 2 2 0 Primase helical domain Ank_4 PF13637.6 EFC40058.1 - 0.011 16.3 0.0 0.039 14.6 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC40058.1 - 0.012 16.2 0.0 0.029 15.0 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank PF00023.30 EFC40058.1 - 0.12 12.9 0.0 0.3 11.6 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeat DUF547 PF04784.14 EFC40059.1 - 7.5e-26 90.6 0.0 2.9e-25 88.7 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function, DUF547 RGS PF00615.19 EFC40059.1 - 3.3e-19 69.3 0.6 3.3e-19 69.3 0.6 4.2 4 0 0 4 4 4 1 Regulator of G protein signaling domain DEP PF00610.21 EFC40059.1 - 6.1e-08 32.6 0.2 2.2e-07 30.8 0.2 2.0 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Trypsin_2 PF13365.6 EFC40059.1 - 0.00093 20.1 0.0 0.0023 18.8 0.0 1.7 1 0 0 1 1 1 1 Trypsin-like peptidase domain EGF_2 PF07974.13 EFC40060.1 - 3.1e-21 75.4 105.0 0.00017 21.8 6.2 7.6 7 0 0 7 7 7 7 EGF-like domain RIFIN PF02009.16 EFC40060.1 - 0.0043 17.0 1.0 0.0074 16.2 1.0 1.3 1 0 0 1 1 1 1 Rifin ECSCR PF15820.5 EFC40060.1 - 0.014 15.2 1.9 0.045 13.6 1.9 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF5385 PF17359.2 EFC40060.1 - 0.24 11.0 0.3 0.36 10.4 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) EGF PF00008.27 EFC40060.1 - 0.32 11.3 76.1 0.22 11.9 2.0 7.9 7 0 0 7 7 7 0 EGF-like domain Arm PF00514.23 EFC40061.1 - 1.2e-21 75.9 14.5 5.9e-12 45.2 0.0 8.5 10 1 0 10 10 10 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC40061.1 - 1.6e-10 41.2 0.0 3.6e-05 24.2 0.0 3.0 2 0 0 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.6 EFC40061.1 - 7.8e-08 32.6 0.0 0.0093 16.3 0.0 3.8 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 EFC40061.1 - 1.5e-06 28.0 0.6 0.016 15.4 0.0 4.0 3 0 0 3 3 3 2 HEAT repeat RICTOR_V PF14668.6 EFC40061.1 - 0.00013 22.1 6.6 1.7 9.0 0.3 4.7 5 1 1 6 6 6 3 Rapamycin-insensitive companion of mTOR, domain 5 EF-hand_4 PF12763.7 EFC40061.1 - 0.073 13.0 1.7 4.9 7.1 0.0 2.9 3 0 0 3 3 3 0 Cytoskeletal-regulatory complex EF hand HEAT_PBS PF03130.16 EFC40061.1 - 0.085 13.6 0.2 3.3 8.6 0.0 3.7 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat PI31_Prot_C PF08577.11 EFC40062.1 - 0.0067 17.6 0.3 0.015 16.5 0.3 1.7 1 0 0 1 1 1 1 PI31 proteasome regulator Arf PF00025.21 EFC40063.1 - 2e-62 209.7 0.0 2.2e-62 209.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC40063.1 - 4.1e-14 52.8 0.0 5.8e-14 52.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC40063.1 - 9.7e-14 51.2 0.0 1.2e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC40063.1 - 5.5e-13 48.8 2.6 1.6e-10 40.7 0.6 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 EFC40063.1 - 2.6e-12 46.6 0.0 2.8e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFC40063.1 - 1.6e-11 44.0 0.1 2e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC40063.1 - 8.9e-05 22.6 0.0 0.00014 22.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 EFC40063.1 - 0.0012 18.8 0.3 0.066 13.1 0.0 2.1 2 0 0 2 2 2 1 NACHT domain MeaB PF03308.16 EFC40063.1 - 0.0049 15.9 0.0 0.013 14.5 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 EFC40063.1 - 0.0097 16.3 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 EFC40063.1 - 0.022 14.6 0.2 0.074 12.8 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFC40063.1 - 0.032 14.2 0.2 2.9 7.8 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase cobW PF02492.19 EFC40063.1 - 0.033 13.8 0.4 3.7 7.1 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 EFC40063.1 - 0.15 12.4 0.1 0.45 10.9 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain Peptidase_M20 PF01546.28 EFC40064.1 - 1.5e-28 99.9 0.0 2.1e-28 99.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC40064.1 - 8.8e-10 38.5 0.1 3e-09 36.8 0.1 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFC40064.1 - 0.11 12.1 0.1 0.53 9.9 0.0 1.9 2 1 0 2 2 2 0 Peptidase family M28 Tubulin PF00091.25 EFC40066.1 - 8e-39 133.9 0.4 8e-39 133.9 0.4 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC40066.1 - 0.11 12.7 1.6 0.27 11.4 1.6 1.7 1 0 0 1 1 1 0 Tubulin C-terminal domain DUF4116 PF13475.6 EFC40068.1 - 7.1e-18 64.1 7.5 5.4e-08 32.4 0.2 3.9 3 1 0 3 3 3 3 Domain of unknown function (DUF4116) DUF4384 PF14326.6 EFC40069.1 - 0.015 15.4 0.0 0.025 14.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) RNA_POL_M_15KD PF02150.16 EFC40070.1 - 2.9e-09 36.7 3.5 2.9e-09 36.7 3.5 2.5 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 EFC40070.1 - 0.00059 19.6 11.9 0.00067 19.5 1.3 3.7 3 1 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.7 EFC40070.1 - 0.0028 17.7 6.9 0.026 14.6 0.4 2.8 2 1 0 2 2 2 1 Double zinc ribbon DUF2757 PF10955.8 EFC40070.1 - 0.012 15.9 1.8 3.8 7.8 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) PhnA_Zn_Ribbon PF08274.12 EFC40070.1 - 0.044 13.8 3.4 0.13 12.2 0.0 3.0 3 0 0 3 3 3 0 PhnA Zinc-Ribbon Zn_Tnp_IS1595 PF12760.7 EFC40070.1 - 0.074 13.0 8.8 1.6 8.8 1.2 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-C4_Topoisom PF01396.19 EFC40070.1 - 0.14 12.0 4.7 0.16 11.8 0.0 2.7 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Zn-ribbon_8 PF09723.10 EFC40070.1 - 0.22 11.7 10.6 7.6 6.7 0.3 3.8 4 0 0 4 4 4 0 Zinc ribbon domain Lar_restr_allev PF14354.6 EFC40070.1 - 0.28 11.6 0.4 0.28 11.6 0.4 2.4 2 1 0 2 2 2 0 Restriction alleviation protein Lar zinc_ribbon_10 PF10058.9 EFC40070.1 - 0.48 10.2 11.7 0.45 10.3 2.2 3.2 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein zinc_ribbon_4 PF13717.6 EFC40070.1 - 0.6 10.1 8.2 15 5.6 0.1 3.9 4 0 0 4 4 4 0 zinc-ribbon domain PADR1 PF08063.12 EFC40070.1 - 1.3 8.8 10.3 2.2 8.1 1.2 2.9 2 2 0 2 2 2 0 PADR1 (NUC008) domain zf-ribbon_3 PF13248.6 EFC40070.1 - 1.4 8.4 11.9 2.6 7.6 0.6 3.4 4 0 0 4 4 4 0 zinc-ribbon domain Rpr2 PF04032.16 EFC40070.1 - 2.2 8.6 6.6 7.3 6.9 6.6 2.3 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain A2L_zn_ribbon PF08792.10 EFC40070.1 - 4.9 7.0 11.1 23 4.8 0.1 4.1 4 0 0 4 4 4 0 A2L zinc ribbon domain DUF1610 PF07754.11 EFC40070.1 - 6 6.9 9.9 8.4 6.5 0.8 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) zf-H2C2_5 PF13909.6 EFC40070.1 - 9.6 6.1 12.1 0.56 10.0 4.4 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DEAD PF00270.29 EFC40071.1 - 3e-22 79.2 0.2 3.5e-22 79.0 0.2 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 EFC40071.1 - 0.0015 17.9 0.1 0.0022 17.4 0.1 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 EFC40071.1 - 0.13 12.2 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF3490 PF11995.8 EFC40072.1 - 0.19 11.6 3.9 0.51 10.1 3.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) FAM199X PF15814.5 EFC40072.1 - 0.49 9.4 10.4 0.94 8.5 10.4 1.4 1 0 0 1 1 1 0 Protein family FAM199X AF-4 PF05110.13 EFC40072.1 - 1.4 6.9 12.6 2.1 6.3 12.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF3340 PF11818.8 EFC40072.1 - 1.6 8.8 16.6 0.32 11.1 8.2 2.4 1 1 1 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) SPRY PF00622.28 EFC40073.1 - 0.0055 16.8 0.3 0.0092 16.1 0.3 1.3 1 0 0 1 1 1 1 SPRY domain LRR_6 PF13516.6 EFC40074.1 - 3.2e-29 98.5 20.3 1.4e-05 24.7 0.2 9.9 10 0 0 10 10 10 8 Leucine Rich repeat LRR_8 PF13855.6 EFC40074.1 - 6.3e-18 64.3 23.0 1.1e-06 28.3 3.6 4.6 2 2 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC40074.1 - 1.1e-11 44.8 28.0 0.00034 20.9 0.6 5.7 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40074.1 - 7.1e-07 28.9 15.7 9.4 7.2 0.0 8.4 9 0 0 9 9 9 4 Leucine Rich Repeat F-box-like PF12937.7 EFC40074.1 - 0.0037 17.1 0.2 0.0074 16.2 0.2 1.5 1 0 0 1 1 1 1 F-box-like DUF4869 PF16163.5 EFC40074.1 - 2.2 8.0 9.2 1.9 8.2 0.5 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4869) Ras PF00071.22 EFC40075.1 - 4.5e-23 81.6 0.1 9.9e-23 80.5 0.0 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC40075.1 - 3.2e-11 43.5 0.0 5.7e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40075.1 - 5.2e-10 39.1 0.0 7.7e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC40075.1 - 9.8e-09 34.9 0.1 1.4e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region F-box PF00646.33 EFC40075.1 - 1.7e-07 30.9 0.2 4e-07 29.7 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC40075.1 - 7.6e-05 22.5 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 EFC40075.1 - 0.00066 19.7 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC40075.1 - 0.0023 17.6 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC40075.1 - 0.0053 16.7 0.0 0.021 14.7 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 EFC40075.1 - 0.0092 16.5 0.0 0.021 15.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 EFC40075.1 - 0.016 14.7 0.0 0.037 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 EFC40075.1 - 0.017 15.4 0.0 0.061 13.6 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFC40075.1 - 0.017 15.2 0.0 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain F-box_4 PF15966.5 EFC40075.1 - 0.018 14.9 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 F-box AAA_16 PF13191.6 EFC40075.1 - 0.029 14.7 0.0 0.05 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain PRANC PF09372.10 EFC40075.1 - 0.054 13.8 0.7 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 PRANC domain AFG1_ATPase PF03969.16 EFC40075.1 - 0.1 11.5 0.0 0.19 10.6 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase NB-ARC PF00931.22 EFC40075.1 - 0.11 11.7 0.0 0.2 10.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain Deltameth_res PF16020.5 EFC40076.1 - 0.17 11.8 1.4 1.2 9.1 0.1 2.3 1 1 1 2 2 2 0 Deltamethrin resistance TPR_2 PF07719.17 EFC40077.1 - 6.9e-05 22.7 0.1 0.088 13.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40077.1 - 0.002 17.8 1.0 0.059 13.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40077.1 - 0.0073 16.8 0.0 0.29 11.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40077.1 - 0.011 16.0 0.2 3 8.2 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40077.1 - 0.015 14.9 0.8 0.04 13.6 0.2 2.0 2 0 0 2 2 2 0 TPR repeat TPR_8 PF13181.6 EFC40077.1 - 0.031 14.5 3.7 0.49 10.7 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_5 PF12688.7 EFC40077.1 - 0.1 12.9 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat DUF2859 PF11072.8 EFC40078.1 - 0.0049 16.6 0.0 0.0063 16.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2859) DUF3482 PF11981.8 EFC40079.1 - 0.045 13.2 0.3 0.045 13.2 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3482) DDE_Tnp_1_3 PF13612.6 EFC40079.1 - 0.11 12.4 4.5 0.18 11.8 0.4 2.4 2 0 0 2 2 2 0 Transposase DDE domain DHC PF09626.10 EFC40079.1 - 1.7 9.6 4.3 3.7 8.5 0.2 3.0 3 0 0 3 3 3 0 Dihaem cytochrome c Pkinase PF00069.25 EFC40080.1 - 9e-56 189.1 0.2 1.9e-55 188.0 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40080.1 - 4.4e-33 114.7 0.1 8e-33 113.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC40080.1 - 0.00053 19.0 1.7 0.0008 18.5 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC40080.1 - 0.0037 16.1 0.0 0.0067 15.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC40080.1 - 0.0049 16.8 0.2 0.14 12.1 0.1 2.6 3 0 0 3 3 3 1 Phosphotransferase enzyme family DRIM PF07539.12 EFC40080.1 - 0.0053 15.1 0.2 0.008 14.5 0.2 1.2 1 0 0 1 1 1 1 Down-regulated in metastasis FTA2 PF13095.6 EFC40080.1 - 0.0086 15.7 0.1 0.8 9.3 0.0 2.4 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Band_7 PF01145.25 EFC40081.1 - 7.9e-07 29.2 0.1 7.9e-07 29.2 0.1 3.0 3 0 0 3 3 3 1 SPFH domain / Band 7 family DUF896 PF05979.12 EFC40081.1 - 0.41 10.6 5.6 1.9 8.4 0.4 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF896) Ribosomal_S30 PF04758.14 EFC40082.1 - 0.034 14.3 0.6 0.034 14.3 0.6 1.9 2 0 0 2 2 2 0 Ribosomal protein S30 p450 PF00067.22 EFC40084.1 - 2e-71 241.1 2.2 3e-71 240.6 2.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF1430 PF07242.11 EFC40084.1 - 0.066 13.5 6.7 0.15 12.3 6.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) VPS28 PF03997.12 EFC40085.1 - 1.9e-67 226.7 2.0 2.4e-67 226.3 2.0 1.1 1 0 0 1 1 1 1 VPS28 protein ATG16 PF08614.11 EFC40085.1 - 0.0047 17.2 1.9 0.45 10.7 0.2 2.4 2 1 1 3 3 3 2 Autophagy protein 16 (ATG16) PAP_central PF04928.17 EFC40085.1 - 0.066 12.2 0.1 0.08 11.9 0.1 1.2 1 0 0 1 1 1 0 Poly(A) polymerase central domain WD40 PF00400.32 EFC40086.1 - 9.8e-35 118.0 1.3 1.4e-06 28.9 0.1 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Katanin_con80 PF13925.6 EFC40086.1 - 1.9e-31 109.3 1.7 3.4e-31 108.4 1.7 1.4 1 0 0 1 1 1 1 con80 domain of Katanin ANAPC4_WD40 PF12894.7 EFC40086.1 - 2.1e-16 60.0 0.3 5e-07 29.9 0.0 4.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC40086.1 - 6.4e-06 26.2 0.3 0.0066 16.3 0.1 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFC40086.1 - 0.0082 15.1 0.1 0.14 11.1 0.0 2.7 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 EFC40086.1 - 0.027 13.2 0.0 0.57 8.9 0.0 2.6 2 1 0 3 3 3 0 Nup133 N terminal like Nup160 PF11715.8 EFC40086.1 - 0.062 11.9 0.1 1.7 7.2 0.0 2.7 1 1 2 3 3 3 0 Nucleoporin Nup120/160 NAD_binding_10 PF13460.6 EFC40087.1 - 6.8e-09 35.9 0.0 9.9e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFC40087.1 - 1.1e-07 31.2 0.4 1.7e-07 30.6 0.4 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC40087.1 - 3.2e-07 30.1 0.0 7.5e-07 28.8 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFC40087.1 - 0.00014 21.5 0.0 0.0009 18.9 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 EFC40087.1 - 0.00033 20.6 0.0 0.00048 20.1 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 EFC40087.1 - 0.00089 18.8 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 EFC40087.1 - 0.00099 18.6 0.0 0.0022 17.4 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 EFC40087.1 - 0.0074 16.4 0.1 0.013 15.7 0.1 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.20 EFC40087.1 - 0.059 13.4 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase RmlD_sub_bind PF04321.17 EFC40087.1 - 0.16 11.0 0.0 0.33 10.0 0.0 1.5 1 0 0 1 1 1 0 RmlD substrate binding domain vWA-TerF-like PF10138.9 EFC40088.1 - 0.047 13.8 1.5 0.33 11.0 0.1 2.1 1 1 1 2 2 2 0 vWA found in TerF C terminus UBX PF00789.20 EFC40089.1 - 1.7e-10 40.9 0.1 3.2e-10 40.1 0.1 1.4 1 0 0 1 1 1 1 UBX domain RR_TM4-6 PF06459.12 EFC40089.1 - 0.21 11.4 13.9 0.3 10.9 13.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tox-ODYAM1 PF15642.6 EFC40089.1 - 0.36 9.7 5.5 0.44 9.5 5.5 1.1 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus Perilipin PF03036.16 EFC40089.1 - 0.65 9.0 9.1 0.86 8.6 9.1 1.2 1 0 0 1 1 1 0 Perilipin family DUF874 PF05917.11 EFC40089.1 - 1.6 7.7 12.7 2.2 7.2 12.7 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Paramyxo_ncap PF00973.19 EFC40089.1 - 1.8 7.4 10.1 2 7.2 9.5 1.3 1 1 0 1 1 1 0 Paramyxovirus nucleocapsid protein Presenilin PF01080.17 EFC40089.1 - 2.2 6.9 9.2 2.8 6.6 9.2 1.2 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 EFC40089.1 - 4 6.7 14.7 5.3 6.3 14.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PSK_trans_fac PF07704.11 EFC40090.1 - 0.0014 19.3 1.8 0.28 12.0 0.1 2.1 1 1 1 2 2 2 2 Rv0623-like transcription factor HD_4 PF13328.6 EFC40090.1 - 0.078 12.7 1.3 0.13 12.0 1.3 1.7 1 1 0 1 1 1 0 HD domain DUF2408 PF10303.9 EFC40090.1 - 0.14 12.7 11.3 0.32 11.6 11.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) TraG-D_C PF12696.7 EFC40090.1 - 0.64 10.0 9.0 0.26 11.3 5.3 2.1 2 1 0 2 2 2 0 TraM recognition site of TraD and TraG DUF913 PF06025.12 EFC40090.1 - 0.7 8.8 8.6 0.82 8.6 8.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF749 PF05370.11 EFC40090.1 - 0.78 9.9 11.5 0.8 9.8 7.3 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF749) DASH_Dad3 PF08656.10 EFC40090.1 - 6.1 7.0 9.1 1.4e+02 2.7 9.1 2.6 1 1 0 1 1 1 0 DASH complex subunit Dad3 DUF4116 PF13475.6 EFC40092.1 - 8.5e-48 159.9 35.0 1.7e-09 37.2 0.1 10.7 6 4 4 11 11 11 10 Domain of unknown function (DUF4116) VWA_2 PF13519.6 EFC40093.1 - 2.7e-13 50.5 0.2 9.8e-13 48.7 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFC40093.1 - 6e-10 39.6 0.2 1.2e-09 38.6 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain TssR PF17643.1 EFC40093.1 - 0.00086 17.4 0.8 0.001 17.1 0.0 1.4 2 0 0 2 2 2 1 Type VI secretion system, TssR VWA_3 PF13768.6 EFC40093.1 - 0.039 13.9 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain Aldedh PF00171.22 EFC40094.1 - 2.1e-126 422.2 0.6 2.8e-126 421.7 0.6 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MKT1_C PF12246.8 EFC40095.1 - 3.2e-40 137.9 1.4 4.9e-40 137.3 1.4 1.3 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 EFC40095.1 - 2.8e-21 75.7 0.0 8.9e-21 74.1 0.0 2.0 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 EFC40095.1 - 1.9e-12 47.5 0.0 8.2e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EFC40095.1 - 4.8e-05 23.6 0.0 0.00014 22.2 0.0 1.8 1 0 0 1 1 1 1 XPG I-region DUF1744 PF08490.12 EFC40096.1 - 8.3e-83 278.2 8.4 7.2e-82 275.1 8.4 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 EFC40096.1 - 1.5e-65 221.6 7.8 1.5e-65 221.6 7.8 2.4 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 EFC40096.1 - 1.1e-18 67.2 11.7 4e-17 62.1 6.3 4.4 3 1 0 3 3 3 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 EFC40096.1 - 3.6e-07 30.1 0.6 2.9e-06 27.1 0.6 2.6 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 EFC40096.1 - 0.00033 20.7 0.0 0.0023 18.0 0.0 2.5 1 0 0 1 1 1 1 RNase_H superfamily DUF1818 PF08848.11 EFC40096.1 - 0.072 13.2 0.2 0.31 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1818) F-box-like_2 PF13013.6 EFC40096.1 - 0.079 12.9 0.5 0.37 10.8 0.5 2.1 1 0 0 1 1 1 0 F-box-like domain CENP-B_dimeris PF09026.10 EFC40096.1 - 4.9 7.6 6.3 20 5.7 6.3 2.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Actin PF00022.19 EFC40097.1 - 8.6e-65 218.9 0.0 6.5e-64 216.0 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC40097.1 - 0.033 13.0 0.0 0.92 8.3 0.0 2.3 2 0 0 2 2 2 0 MreB/Mbl protein tRNA-synt_2b PF00587.25 EFC40098.1 - 2.6e-39 135.0 0.0 6e-39 133.9 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFC40098.1 - 2.8e-17 62.7 0.3 1.2e-16 60.7 0.1 2.1 2 0 0 2 2 2 1 Anticodon binding domain tRNA_SAD PF07973.14 EFC40098.1 - 2.4e-13 49.9 0.0 5.7e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DUF3106 PF11304.8 EFC40098.1 - 0.036 14.5 0.4 0.13 12.8 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) INT_SG_DDX_CT_C PF15300.6 EFC40098.1 - 0.045 13.5 1.9 0.18 11.7 0.0 2.6 2 0 0 2 2 2 0 INTS6/SAGE1/DDX26B/CT45 C-terminus Tubulin PF00091.25 EFC40099.1 - 2.8e-35 122.3 1.1 2.8e-35 122.3 1.1 1.9 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EFC40099.1 - 0.00093 18.5 1.8 0.0012 18.1 1.1 1.6 1 1 0 1 1 1 1 Tubulin like Spaetzle PF16077.5 EFC40099.1 - 0.0036 17.8 0.4 0.013 16.1 0.4 1.9 1 0 0 1 1 1 1 Spaetzle Phage-A118_gp45 PF10653.9 EFC40099.1 - 0.018 15.1 2.7 0.25 11.4 0.2 3.2 2 1 1 3 3 3 0 Protein gp45 of Bacteriophage A118 Pkinase PF00069.25 EFC40100.1 - 3e-24 85.8 2.2 3.7e-24 85.5 0.3 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40100.1 - 2.2e-15 56.7 0.1 4.1e-15 55.8 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_8 PF13181.6 EFC40100.1 - 3.5e-14 51.7 7.0 0.00074 19.5 0.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC40100.1 - 1.9e-12 46.3 5.8 0.0038 17.2 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40100.1 - 3.6e-11 42.4 11.8 0.00012 21.7 0.1 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40100.1 - 1.7e-07 31.1 1.7 0.0027 18.0 0.0 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40100.1 - 6.5e-05 23.1 0.0 14 6.0 0.0 4.2 3 1 0 4 4 4 1 Tetratricopeptide repeat Pkinase_fungal PF17667.1 EFC40100.1 - 0.00065 18.6 0.1 0.0016 17.3 0.1 1.6 1 0 0 1 1 1 1 Fungal protein kinase TPR_7 PF13176.6 EFC40100.1 - 0.0011 18.8 0.1 22 5.4 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC40100.1 - 0.0012 19.4 0.6 7.3 7.5 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat RPW8 PF05659.11 EFC40100.1 - 0.16 11.7 7.7 3 7.5 0.3 2.8 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TPR_11 PF13414.6 EFC40100.1 - 0.17 11.6 0.5 1.2 8.8 0.0 2.7 3 0 0 3 3 3 0 TPR repeat IFT57 PF10498.9 EFC40101.1 - 0.00071 18.6 14.5 0.00071 18.6 14.5 5.6 2 2 3 5 5 5 2 Intra-flagellar transport protein 57 DUF4200 PF13863.6 EFC40101.1 - 0.0084 16.5 16.9 0.0084 16.5 16.9 6.7 4 1 2 6 6 6 1 Domain of unknown function (DUF4200) kleA_kleC PF17383.2 EFC40101.1 - 0.039 14.3 0.1 0.039 14.3 0.1 5.8 6 1 1 7 7 7 0 Uncharacterized KorC regulated protein A TRM PF02005.16 EFC40103.1 - 2e-132 441.9 0.3 2.7e-132 441.5 0.3 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 EFC40103.1 - 0.0055 16.5 0.1 0.019 14.7 0.1 1.8 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_16 PF10294.9 EFC40103.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase TFIIA PF03153.13 EFC40103.1 - 2.4 8.0 29.5 0.081 12.9 9.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit SAP PF02037.27 EFC40104.1 - 3.8e-07 29.7 1.6 7.6e-07 28.7 1.6 1.5 1 0 0 1 1 1 1 SAP domain Phi-29_GP16_7 PF06720.11 EFC40104.1 - 0.00026 20.8 1.3 0.00077 19.3 1.3 1.7 1 0 0 1 1 1 1 Bacteriophage phi-29 early protein GP16.7 ETF_alpha PF00766.19 EFC40105.1 - 9.4e-34 115.3 0.1 1.7e-33 114.4 0.1 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 EFC40105.1 - 1.1e-18 67.8 0.0 1.7e-18 67.2 0.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain SBDS PF01172.18 EFC40105.1 - 0.015 15.4 0.4 0.044 13.9 0.3 1.8 1 1 0 1 1 1 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein YhdB PF14148.6 EFC40105.1 - 0.48 10.6 2.8 0.44 10.7 0.9 1.9 2 0 0 2 2 2 0 YhdB-like protein ACOX PF01756.19 EFC40106.1 - 5.7e-23 81.4 1.6 1.1e-22 80.4 1.6 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFC40106.1 - 8.5e-15 54.7 0.0 1.8e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFC40106.1 - 1.2e-09 38.6 0.7 3.7e-09 37.0 0.1 2.2 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain DUF1953 PF09196.10 EFC40106.1 - 0.052 13.4 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1953) Pkinase PF00069.25 EFC40107.1 - 1.5e-43 149.1 0.2 2.7e-43 148.2 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40107.1 - 8e-33 113.8 0.0 1.8e-32 112.7 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC40107.1 - 2.3e-05 23.3 0.0 3.5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIFIN PF02009.16 EFC40107.1 - 3.1e-05 24.0 1.5 9.2e-05 22.5 1.5 1.8 1 0 0 1 1 1 1 Rifin GPS PF01825.21 EFC40107.1 - 0.00024 21.5 0.7 0.00055 20.4 0.7 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DAG1 PF05454.11 EFC40107.1 - 0.0012 18.3 1.0 0.0023 17.3 1.0 1.4 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Syndecan PF01034.20 EFC40107.1 - 0.0021 18.0 1.4 0.005 16.7 1.4 1.6 1 0 0 1 1 1 1 Syndecan domain TMEM154 PF15102.6 EFC40107.1 - 0.0065 16.4 2.7 0.0065 16.4 2.7 2.5 1 1 1 2 2 2 1 TMEM154 protein family DUF5385 PF17359.2 EFC40107.1 - 0.011 15.3 2.1 0.021 14.4 2.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) ASFV_J13L PF05568.11 EFC40107.1 - 0.019 14.8 0.2 0.049 13.4 0.2 1.8 1 0 0 1 1 1 0 African swine fever virus J13L protein ECSCR PF15820.5 EFC40107.1 - 0.023 14.5 0.6 0.085 12.7 0.6 2.0 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Orf78 PF06024.12 EFC40107.1 - 0.023 15.0 0.4 0.023 15.0 0.4 1.9 2 0 0 2 2 1 0 Orf78 (ac78) Shisa PF13908.6 EFC40107.1 - 0.024 14.9 2.8 0.06 13.6 2.8 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Stevor PF17410.2 EFC40107.1 - 0.034 13.7 1.9 0.14 11.7 1.9 2.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame APH PF01636.23 EFC40107.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1043 PF06295.12 EFC40107.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) EphA2_TM PF14575.6 EFC40107.1 - 0.17 12.8 0.9 0.42 11.5 0.2 2.0 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.6 EFC40107.1 - 0.24 11.1 2.2 0.39 10.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF3377 PF11857.8 EFC40107.1 - 0.36 10.8 4.7 0.064 13.2 0.8 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF3377) FeoB_associated PF12669.7 EFC40107.1 - 0.56 10.6 4.9 1.2 9.6 4.9 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein EMC3_TMCO1 PF01956.16 EFC40107.1 - 8.5 6.1 8.9 0.28 10.9 0.8 2.4 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like TSCPD PF12637.7 EFC40108.1 - 0.094 13.0 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 TSCPD domain Alginate_lyase2 PF08787.11 EFC40109.1 - 1.3e-32 113.5 1.8 1.5e-32 113.3 1.8 1.0 1 0 0 1 1 1 1 Alginate lyase Na_Ca_ex PF01699.24 EFC40110.1 - 0.0027 17.7 0.3 0.0027 17.7 0.3 2.0 2 1 0 2 2 2 1 Sodium/calcium exchanger protein DUF5077 PF16871.5 EFC40110.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 1 0 2 2 2 0 Domain of unknown function (DUF5077) PTP_tm PF18861.1 EFC40110.1 - 0.15 12.0 1.8 0.3 11.1 1.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Hydrolase_4 PF12146.8 EFC40111.1 - 2.5e-09 36.7 0.0 1.7e-06 27.5 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC40111.1 - 2.3e-08 34.0 0.0 2e-07 30.9 0.0 1.9 1 1 1 2 2 2 1 alpha/beta hydrolase fold UPF0227 PF05728.12 EFC40111.1 - 7.3e-07 29.3 0.0 9.9e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_5 PF12695.7 EFC40111.1 - 0.012 15.4 0.0 0.067 12.9 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family BTB PF00651.31 EFC40112.1 - 0.0013 18.9 0.6 0.0034 17.6 0.6 1.8 1 0 0 1 1 1 1 BTB/POZ domain Zn_clus PF00172.18 EFC40112.1 - 0.0014 18.7 13.1 0.003 17.6 13.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Spore_Cse60 PF10957.8 EFC40112.1 - 0.4 10.8 2.8 0.79 9.8 0.1 2.6 2 0 0 2 2 2 0 Sporulation protein Cse60 Peptidase_S15 PF02129.18 EFC40113.1 - 3.9e-42 144.7 0.0 7.5e-42 143.8 0.0 1.5 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EFC40113.1 - 2.1e-22 80.2 0.0 4.5e-22 79.1 0.0 1.4 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S9 PF00326.21 EFC40113.1 - 0.00056 19.4 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC40113.1 - 0.0016 18.1 0.0 0.0036 17.0 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC40113.1 - 0.002 17.4 0.0 0.0076 15.5 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 LRR_4 PF12799.7 EFC40114.1 - 0.012 16.1 15.0 0.67 10.5 0.1 6.9 6 2 2 8 8 8 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40114.1 - 0.034 14.7 3.9 32 5.6 0.1 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat C2 PF00168.30 EFC40116.1 - 5.7e-23 81.2 1.3 5.8e-23 81.1 0.1 1.6 2 0 0 2 2 2 1 C2 domain CitMHS PF03600.16 EFC40118.1 - 4.1e-48 164.1 0.0 3.2e-40 138.2 0.0 2.2 1 1 1 2 2 2 2 Citrate transporter TrkA_C PF02080.21 EFC40118.1 - 2.4e-05 24.1 0.0 0.0049 16.7 0.0 2.7 2 0 0 2 2 2 2 TrkA-C domain RNA_pol_Rpb5_C PF01191.19 EFC40118.1 - 0.11 12.3 0.1 0.35 10.8 0.1 1.8 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain DUF2730 PF10805.8 EFC40119.1 - 0.0056 16.8 0.2 0.017 15.2 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2730) Baculo_PEP_C PF04513.12 EFC40119.1 - 0.026 14.6 0.6 0.053 13.6 0.6 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4709 PF15821.5 EFC40119.1 - 0.056 13.7 4.7 0.94 9.8 0.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4709) Tsg PF04668.12 EFC40119.1 - 2.1 9.0 8.1 9.2 6.9 0.2 2.9 3 0 0 3 3 3 0 Twisted gastrulation (Tsg) protein conserved region TMIE PF16038.5 EFC40119.1 - 2.5 8.0 6.5 0.68 9.8 2.5 2.1 2 0 0 2 2 2 0 TMIE protein Peptidase_C1 PF00112.23 EFC40120.1 - 4e-74 249.4 6.6 5.6e-74 248.9 6.6 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFC40120.1 - 5.4e-08 33.2 0.6 1.1e-07 32.2 0.6 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFC40120.1 - 7.8e-05 21.6 0.6 0.055 12.2 0.1 2.5 3 0 0 3 3 3 2 Peptidase C1-like family Ibs_toxin PF13956.6 EFC40120.1 - 0.42 10.7 1.8 0.77 9.8 1.8 1.4 1 0 0 1 1 1 0 Toxin Ibs, type I toxin-antitoxin system Lactamase_B PF00753.27 EFC40121.1 - 1.9e-19 70.5 1.1 2.3e-19 70.2 1.1 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC40121.1 - 0.033 13.7 1.8 0.047 13.2 1.8 1.4 1 1 0 1 1 1 0 Beta-lactamase superfamily domain SpoIIID PF12116.8 EFC40121.1 - 0.14 12.2 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Stage III sporulation protein D BACK PF07707.15 EFC40122.1 - 3.2e-19 69.0 0.9 3.3e-17 62.5 0.1 2.8 3 0 0 3 3 3 2 BTB And C-terminal Kelch BTB PF00651.31 EFC40122.1 - 1.6e-14 54.1 0.1 5.1e-14 52.5 0.1 2.0 1 0 0 1 1 1 1 BTB/POZ domain Guanylate_cyc PF00211.20 EFC40123.1 - 8.9e-57 191.7 0.2 2.1e-56 190.5 0.2 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40123.1 - 2.2e-14 53.6 0.0 9.3e-14 51.6 0.0 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC40123.1 - 3.1e-10 40.0 0.0 8e-10 38.7 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC40123.1 - 0.024 14.9 0.0 0.049 13.9 0.0 1.4 1 0 0 1 1 1 0 PAS fold Ras PF00071.22 EFC40124.1 - 6.7e-11 42.0 0.0 9.7e-11 41.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40124.1 - 0.00029 21.0 0.0 0.00058 20.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF562 PF04763.12 EFC40124.1 - 0.087 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF562) Aa_trans PF01490.18 EFC40125.1 - 9.5e-65 218.9 26.6 1.5e-45 155.6 17.4 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein DUF1348 PF07080.11 EFC40127.1 - 1.2e-61 206.4 8.2 1.3e-61 206.2 8.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1348) SnoaL_2 PF12680.7 EFC40127.1 - 1.6e-06 28.7 0.0 2.1e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 EFC40127.1 - 0.00017 21.9 0.0 0.00022 21.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) DUF2604 PF10790.9 EFC40127.1 - 0.0071 16.6 0.9 0.048 14.0 0.2 2.3 2 1 1 3 3 3 1 Protein of Unknown function (DUF2604) UPF0270 PF06794.12 EFC40128.1 - 0.15 12.2 0.0 0.41 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) YMF19 PF02326.15 EFC40128.1 - 0.61 10.9 5.4 1.6 9.6 5.4 1.8 1 0 0 1 1 1 0 Plant ATP synthase F0 Ferric_reduct PF01794.19 EFC40130.1 - 1.9e-19 70.0 12.9 1.9e-19 70.0 12.9 2.3 2 1 0 2 2 2 1 Ferric reductase like transmembrane component DOMON PF03351.17 EFC40130.1 - 3e-18 66.3 0.3 1.7e-17 63.8 0.0 2.4 3 0 0 3 3 3 1 DOMON domain NAD_binding_6 PF08030.12 EFC40130.1 - 6.9e-16 58.7 0.7 1e-13 51.7 0.7 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC40130.1 - 1.4e-12 47.7 0.2 4.2e-12 46.1 0.2 1.8 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFC40130.1 - 1.2e-06 29.1 0.0 2.3e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Lyase_1 PF00206.20 EFC40131.1 - 2.7e-18 66.4 0.0 4.2e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 EFC40131.1 - 3.8e-15 56.2 0.2 9.4e-15 54.9 0.2 1.7 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus GluR_Homer-bdg PF10606.9 EFC40131.1 - 0.13 12.4 0.4 0.37 11.0 0.4 1.7 1 0 0 1 1 1 0 Homer-binding domain of metabotropic glutamate receptor UCH PF00443.29 EFC40132.1 - 3.9e-54 183.8 4.2 3.9e-54 183.8 4.2 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC40132.1 - 9.1e-21 74.8 9.9 9.1e-21 74.8 9.9 3.4 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase IFRD PF05004.13 EFC40132.1 - 0.00098 18.3 0.5 0.0029 16.8 0.5 1.7 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) FYVE PF01363.21 EFC40132.1 - 0.0013 18.9 9.9 56 4.0 0.0 3.9 3 2 0 3 3 3 0 FYVE zinc finger Zn_ribbon_SprT PF17283.2 EFC40132.1 - 0.55 10.2 10.0 12 5.9 0.1 4.5 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf-ribbon_3 PF13248.6 EFC40132.1 - 2.6 7.6 18.4 1 8.9 0.2 4.5 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_L7Ae PF01248.26 EFC40133.1 - 1e-20 73.3 0.0 1.2e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Hydrolase_6 PF13344.6 EFC40133.1 - 0.095 12.8 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pro_isomerase PF00160.21 EFC40134.1 - 1.3e-48 165.3 0.2 1.4e-48 165.1 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PI31_Prot_C PF08577.11 EFC40136.1 - 3.3e-13 50.6 7.3 3.3e-13 50.6 7.3 1.9 2 0 0 2 2 2 1 PI31 proteasome regulator DUF2505 PF10698.9 EFC40137.1 - 0.00046 20.3 0.0 0.00089 19.4 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2505) GTP_EFTU PF00009.27 EFC40138.1 - 1.6e-58 197.5 0.1 5.1e-58 195.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFC40138.1 - 3.3e-21 75.1 0.0 9.2e-21 73.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFC40138.1 - 6e-20 71.2 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EFC40138.1 - 9.5e-13 48.0 0.0 2.1e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFC40138.1 - 1.8e-10 41.0 0.0 5.5e-10 39.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFC40138.1 - 0.0008 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFC40138.1 - 0.0074 16.4 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MycE_N PF17843.1 EFC40138.1 - 0.13 12.8 0.1 30 5.1 0.0 2.5 2 0 0 2 2 2 0 MycE methyltransferase N-terminal Pkinase PF00069.25 EFC40140.1 - 2.2e-55 187.9 1.2 3.5e-55 187.2 1.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40140.1 - 8.9e-31 107.1 0.3 1.4e-30 106.5 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC40140.1 - 2.9e-14 52.3 3.6 0.001 19.0 0.0 8.4 8 0 0 8 8 8 2 NHL repeat Pkinase_fungal PF17667.1 EFC40140.1 - 1.9e-06 27.0 0.0 3.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF5074 PF16819.5 EFC40140.1 - 1.8e-05 24.7 2.7 8.4 6.5 0.3 6.4 6 0 0 6 6 6 1 Domain of unknown function (DUF5074) EGF_2 PF07974.13 EFC40140.1 - 2.5e-05 24.5 17.0 0.0016 18.8 6.5 2.7 2 0 0 2 2 2 2 EGF-like domain YrbL-PhoP_reg PF10707.9 EFC40140.1 - 0.016 14.7 0.1 0.046 13.2 0.1 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL SGL PF08450.12 EFC40140.1 - 0.027 14.1 0.1 12 5.4 0.1 4.0 2 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region EGF PF00008.27 EFC40140.1 - 0.34 11.3 9.0 0.65 10.4 2.3 2.6 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 EFC40140.1 - 1.1 9.4 13.9 5.1 7.3 6.1 2.4 2 0 0 2 2 2 0 Laminin EGF domain DUF3676 PF12429.8 EFC40142.1 - 0.0018 18.1 2.7 0.0035 17.2 2.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3676) Actin PF00022.19 EFC40143.1 - 2.4e-84 283.3 0.0 2.5e-83 280.0 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC40143.1 - 0.061 12.1 0.0 0.2 10.4 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein Ank_2 PF12796.7 EFC40144.1 - 7.6e-19 68.1 5.9 5.7e-11 42.9 0.5 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC40144.1 - 2.8e-10 40.5 0.1 9e-10 38.9 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC40144.1 - 4.4e-09 36.4 0.6 9.4e-06 25.8 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC40144.1 - 5.1e-08 32.6 0.6 0.0022 18.3 0.1 3.2 2 0 0 2 2 2 2 Ankyrin repeat RGS PF00615.19 EFC40144.1 - 2.4e-06 27.8 2.4 6.8e-06 26.3 2.4 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ank PF00023.30 EFC40144.1 - 5.5e-06 26.6 0.9 0.085 13.3 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeat NMT1 PF09084.11 EFC40144.1 - 0.0001 22.4 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 NMT1/THI5 like SBP_bac_3 PF00497.20 EFC40144.1 - 0.0079 15.6 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 DPM2 PF07297.12 EFC40144.1 - 0.79 10.1 12.2 0.3 11.4 6.4 2.8 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) NUDE_C PF04880.13 EFC40145.1 - 1.5 9.3 7.4 3.6 8.0 7.4 1.6 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Peripla_BP_6 PF13458.6 EFC40146.1 - 4.1e-27 95.8 0.0 2.1e-24 86.8 0.0 2.9 3 0 0 3 3 3 2 Periplasmic binding protein Guanylate_cyc PF00211.20 EFC40146.1 - 5.6e-17 62.0 0.0 1.3e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain FeoB_associated PF12669.7 EFC40146.1 - 8.5 6.9 8.3 0.36 11.3 1.2 2.4 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein PBP_like_2 PF12849.7 EFC40147.1 - 2.5e-24 86.4 2.6 3.3e-24 86.0 2.6 1.1 1 0 0 1 1 1 1 PBP superfamily domain LRR_6 PF13516.6 EFC40148.1 - 4.5e-29 98.0 3.7 0.00011 22.0 0.0 6.5 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC40148.1 - 8.4e-20 70.3 2.4 2.2e-09 37.0 0.0 3.7 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC40148.1 - 2e-13 50.3 15.7 2e-05 24.9 0.0 5.2 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40148.1 - 6.8e-11 41.1 0.6 15 6.6 0.0 7.1 8 0 0 8 8 8 4 Leucine Rich Repeat ApoB100_C PF12491.8 EFC40148.1 - 0.00036 20.4 7.3 1.4 8.9 0.0 6.0 3 1 5 8 8 8 2 Apolipoprotein B100 C terminal LRR_9 PF14580.6 EFC40148.1 - 0.016 14.7 4.4 0.079 12.5 0.2 3.1 1 1 3 4 4 4 0 Leucine-rich repeat F-box-like PF12937.7 EFC40149.1 - 1.2e-06 28.3 0.1 2.7e-06 27.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC40149.1 - 6.6e-05 22.7 0.1 0.00017 21.4 0.1 1.8 1 0 0 1 1 1 1 F-box domain DUF1963 PF09234.10 EFC40149.1 - 0.13 12.7 1.9 0.5 10.8 1.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1963) Paramyxo_C PF01692.18 EFC40150.1 - 0.15 11.4 7.6 0.42 9.9 7.6 1.6 2 0 0 2 2 2 0 Paramyxovirus non-structural protein C Apt1 PF10351.9 EFC40150.1 - 4.9 5.9 11.1 6.8 5.4 11.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ndc1_Nup PF09531.10 EFC40150.1 - 6.1 5.4 8.7 0.34 9.6 3.6 1.4 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 EFC40150.1 - 6.9 5.1 8.2 9.2 4.7 8.2 1.2 1 0 0 1 1 1 0 Macoilin family Trypsin PF00089.26 EFC40151.1 - 2.3e-40 138.7 0.8 2.9e-40 138.4 0.8 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC40151.1 - 4.9e-05 24.3 0.2 0.00021 22.2 0.2 2.0 1 1 0 1 1 1 1 Trypsin-like peptidase domain CorA PF01544.18 EFC40152.1 - 4 6.7 7.3 0.55 9.5 1.5 2.2 1 1 0 2 2 2 0 CorA-like Mg2+ transporter protein ANATO PF01821.18 EFC40152.1 - 6.4 7.7 17.3 12 6.9 1.0 4.3 4 0 0 4 4 4 0 Anaphylotoxin-like domain Clp_N PF02861.20 EFC40152.1 - 6.6 7.0 7.5 15 5.8 0.3 3.7 3 0 0 3 3 3 0 Clp amino terminal domain, pathogenicity island component RWP-RK PF02042.15 EFC40153.1 - 8.7e-07 28.8 0.0 2.1e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 RWP-RK domain HTH_23 PF13384.6 EFC40153.1 - 0.088 12.6 0.2 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain RWP-RK PF02042.15 EFC40154.1 - 1.8e-08 34.2 0.1 3.3e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 RWP-RK domain Sigma70_r4_2 PF08281.12 EFC40154.1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Mga PF08280.11 EFC40154.1 - 0.23 11.5 2.3 0.38 10.8 0.6 2.2 2 1 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain Isochorismatase PF00857.20 EFC40155.1 - 7.9e-21 75.0 0.0 1e-20 74.7 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family Glyco_transf_11 PF01531.16 EFC40155.1 - 0.043 13.0 0.0 0.049 12.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase family 11 Mito_carr PF00153.27 EFC40156.1 - 3.1e-57 190.5 2.2 3.5e-19 68.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFC40156.1 - 0.01 15.0 0.6 0.45 9.6 0.0 2.9 2 1 1 3 3 3 0 Gammaproteobacterial serine protease BTB PF00651.31 EFC40157.1 - 8.4e-24 83.9 1.7 1.1e-22 80.3 0.0 2.7 3 0 0 3 3 3 1 BTB/POZ domain BACK PF07707.15 EFC40157.1 - 3.9e-15 55.8 3.2 5.1e-15 55.4 2.2 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch AAA_9 PF12781.7 EFC40157.1 - 0.027 13.6 2.6 0.084 12.0 0.1 2.2 2 0 0 2 2 2 0 ATP-binding dynein motor region BTB_2 PF02214.22 EFC40157.1 - 0.047 14.1 0.1 0.13 12.6 0.1 1.7 1 0 0 1 1 1 0 BTB/POZ domain Post_transc_reg PF13797.6 EFC40157.1 - 0.15 11.9 2.2 0.14 12.0 0.5 1.8 2 0 0 2 2 2 0 Post-transcriptional regulator Porin_3 PF01459.22 EFC40158.1 - 4.3e-27 95.3 7.3 4.8e-27 95.1 7.3 1.0 1 0 0 1 1 1 1 Eukaryotic porin MAPEG PF01124.18 EFC40159.1 - 2e-10 40.7 3.0 2e-10 40.7 3.0 2.5 2 1 0 2 2 2 1 MAPEG family ATP-synt_8 PF00895.20 EFC40159.1 - 0.21 12.1 0.2 0.21 12.1 0.2 2.2 2 0 0 2 2 2 0 ATP synthase protein 8 WD40 PF00400.32 EFC40160.1 - 4.8e-11 43.0 4.8 2.5 9.1 0.0 9.7 12 0 0 12 12 12 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC40160.1 - 1.5e-05 25.2 0.4 0.41 11.0 0.1 5.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_6 PF13405.6 EFC40160.1 - 0.019 14.9 0.3 0.37 10.8 0.2 2.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.6 EFC40160.1 - 0.024 14.5 1.3 0.048 13.5 0.4 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.6 EFC40160.1 - 0.15 12.5 4.2 0.2 12.1 0.5 3.1 2 1 0 2 2 2 0 EF-hand domain pair PAN_3 PF08277.12 EFC40160.1 - 0.57 10.0 3.5 4.8 7.1 0.0 3.5 2 1 1 3 3 3 0 PAN-like domain CBS PF00571.28 EFC40161.1 - 2.3e-27 95.2 4.6 1.2e-14 54.5 0.5 2.1 2 0 0 2 2 2 2 CBS domain 2_5_RNA_ligase2 PF13563.6 EFC40162.1 - 1.8e-29 102.7 0.0 2.2e-29 102.3 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EFC40162.1 - 0.0011 19.1 0.0 0.047 13.9 0.0 2.3 2 0 0 2 2 2 1 LigT like Phosphoesterase 2OG-FeII_Oxy_3 PF13640.6 EFC40163.1 - 6.2e-12 46.3 0.1 9.6e-12 45.6 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 EFC40163.1 - 0.0088 16.3 0.0 0.023 15.0 0.0 1.6 1 1 1 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Peptidase_C1 PF00112.23 EFC40164.1 - 4.6e-43 147.8 0.8 6.3e-43 147.4 0.8 1.1 1 0 0 1 1 1 1 Papain family cysteine protease PALP PF00291.25 EFC40165.1 - 3.4e-63 213.8 0.0 3.9e-63 213.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_C1 PF00112.23 EFC40166.1 - 1.9e-50 172.0 1.8 2.2e-50 171.7 1.8 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Sortilin_C PF15901.5 EFC40166.1 - 0.14 12.5 1.7 0.22 11.8 1.7 1.3 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, C-terminal LRR_6 PF13516.6 EFC40167.1 - 4.1e-11 42.0 11.5 0.00047 20.0 0.2 3.9 3 0 0 3 3 3 3 Leucine Rich repeat LRR_4 PF12799.7 EFC40167.1 - 0.00065 20.0 5.0 0.00065 20.0 5.0 2.8 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) VIGSSK PF14773.6 EFC40167.1 - 0.087 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Helicase-associated putative binding domain, C-terminal LRR_1 PF00560.33 EFC40167.1 - 0.85 10.4 9.1 6.3 7.8 0.3 3.6 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC40167.1 - 2.7 7.8 17.6 0.82 9.5 10.0 3.2 2 2 0 2 2 2 0 Leucine rich repeat TPR_1 PF00515.28 EFC40169.1 - 1.7e-12 46.6 7.2 9.4e-06 25.2 0.3 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC40169.1 - 1.2e-11 43.8 3.8 7.2e-05 22.6 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40169.1 - 5.5e-07 29.2 1.4 0.0082 15.8 0.1 3.1 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 EFC40169.1 - 1.6e-06 28.5 0.0 0.00019 21.8 0.1 2.6 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40169.1 - 4.7e-06 26.6 0.3 0.033 14.6 0.0 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC40169.1 - 9.4e-06 26.2 0.1 0.0079 16.8 0.2 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40169.1 - 0.00018 22.0 0.0 0.036 14.9 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC40169.1 - 0.00041 20.5 1.2 0.0011 19.2 1.2 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFC40169.1 - 0.0021 18.0 0.0 4.2 7.6 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40169.1 - 0.0023 18.0 0.1 0.0023 18.0 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40169.1 - 0.0062 16.8 0.6 0.094 13.0 0.4 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat NARP1 PF12569.8 EFC40169.1 - 0.0063 15.5 1.8 0.0079 15.2 0.1 1.8 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 DUF983 PF06170.12 EFC40172.1 - 0.035 14.5 5.9 0.075 13.4 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF983) PhoR PF11808.8 EFC40172.1 - 0.14 12.6 1.2 0.3 11.5 1.2 1.5 1 0 0 1 1 1 0 Phosphate regulon sensor protein PhoR AOX PF01786.17 EFC40174.1 - 1.4e-74 250.3 0.2 1.8e-74 250.0 0.2 1.1 1 0 0 1 1 1 1 Alternative oxidase Peptidase_M24 PF00557.24 EFC40175.1 - 4.1e-35 121.4 0.2 5.5e-35 121.0 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 CdiI_2 PF18593.1 EFC40175.1 - 0.18 12.5 0.5 0.6 10.8 0.1 2.0 2 0 0 2 2 2 0 CdiI immunity protein ATP-synt_E PF05680.12 EFC40175.1 - 7.3 7.0 9.1 0.92 9.9 3.4 2.2 2 0 0 2 2 2 0 ATP synthase E chain Imm15 PF15561.6 EFC40177.1 - 0.35 11.1 6.0 0.11 12.8 0.7 2.2 1 1 0 2 2 2 0 Immunity protein 15 EF-hand_7 PF13499.6 EFC40178.1 - 4.2e-18 65.5 0.4 2.5e-08 34.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC40178.1 - 4.7e-17 60.2 0.4 1.9e-06 27.0 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC40178.1 - 5.5e-16 57.1 0.1 2.1e-06 27.2 0.1 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_9 PF14658.6 EFC40178.1 - 1.2e-09 38.3 0.0 1.2e-06 28.8 0.0 2.7 1 1 2 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EFC40178.1 - 1.4e-09 37.6 2.0 0.0011 18.8 0.1 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFC40178.1 - 1e-06 28.0 1.9 8e-05 22.0 0.2 3.0 3 0 0 3 3 3 1 EF hand OST-HTH PF12872.7 EFC40178.1 - 0.029 14.2 0.0 2.9 7.8 0.0 2.7 3 0 0 3 3 3 0 OST-HTH/LOTUS domain EF-hand_4 PF12763.7 EFC40178.1 - 0.03 14.3 0.6 4 7.4 0.1 2.5 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand Peptidase_C97 PF05903.14 EFC40179.1 - 0.00034 20.5 0.1 0.00091 19.1 0.1 1.7 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF3853 PF12964.7 EFC40179.1 - 0.029 14.5 0.2 0.062 13.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) ASL_C PF08328.11 EFC40179.1 - 0.081 13.0 0.3 1.7 8.7 0.0 3.0 2 1 2 4 4 4 0 Adenylosuccinate lyase C-terminal Tox-MPTase3 PF15639.6 EFC40179.1 - 0.11 12.3 0.6 0.43 10.5 0.2 2.1 2 0 0 2 2 2 0 Metallopeptidase toxin 3 LRAT PF04970.13 EFC40179.1 - 0.72 10.2 8.4 0.36 11.1 1.6 3.2 3 1 0 3 3 3 0 Lecithin retinol acyltransferase SGL PF08450.12 EFC40181.1 - 0.0089 15.6 1.2 0.029 14.0 1.2 2.0 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Lactonase PF10282.9 EFC40181.1 - 0.016 14.5 0.2 1.2 8.3 0.0 2.4 1 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Keratin_2_head PF16208.5 EFC40181.1 - 0.59 10.3 43.8 1.8e+04 -9.7 43.8 3.2 1 1 0 1 1 1 0 Keratin type II head KRTAP PF11759.8 EFC40181.1 - 1.7 9.3 51.7 1.7e+04 -3.6 0.1 3.1 2 1 0 2 2 2 0 Keratin-associated matrix Kinesin PF00225.23 EFC40182.1 - 5.3e-25 88.0 0.1 5.3e-25 88.0 0.1 3.6 3 2 0 3 3 2 1 Kinesin motor domain PH PF00169.29 EFC40182.1 - 6.1e-12 46.0 2.1 1.3e-11 44.9 0.2 2.7 2 0 0 2 2 2 1 PH domain Microtub_bd PF16796.5 EFC40182.1 - 2.6e-11 43.7 0.0 2.6e-11 43.7 0.0 3.7 3 1 1 4 4 4 1 Microtubule binding PH_11 PF15413.6 EFC40182.1 - 1.1e-05 25.7 0.1 1.1e-05 25.7 0.1 4.4 3 2 1 4 4 4 1 Pleckstrin homology domain Spc7 PF08317.11 EFC40182.1 - 3.4e-05 22.9 35.2 3.4e-05 22.9 35.2 4.4 3 2 0 4 4 4 2 Spc7 kinetochore protein PH_9 PF15410.6 EFC40182.1 - 0.00011 22.5 0.0 0.00011 22.5 0.0 3.6 3 0 0 3 3 2 1 Pleckstrin homology domain zf-C4H2 PF10146.9 EFC40182.1 - 0.003 17.9 19.0 0.003 17.9 19.0 5.2 1 1 2 4 4 2 1 Zinc finger-containing protein SlyX PF04102.12 EFC40182.1 - 0.0062 17.1 1.6 0.0062 17.1 1.6 8.1 4 2 4 8 8 7 1 SlyX PH_8 PF15409.6 EFC40182.1 - 0.017 15.4 0.1 0.017 15.4 0.1 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain FUSC PF04632.12 EFC40182.1 - 0.12 10.9 6.8 0.67 8.4 1.0 2.3 2 1 0 2 2 2 0 Fusaric acid resistance protein family Surfac_D-trimer PF09006.11 EFC40182.1 - 3.6 7.5 10.1 0.53 10.2 0.1 3.9 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation Laminin_II PF06009.12 EFC40182.1 - 8.1 6.5 69.0 0.023 14.7 10.2 5.7 1 1 3 5 5 4 0 Laminin Domain II Response_reg PF00072.24 EFC40183.1 - 7.4e-19 68.0 0.2 1.8e-18 66.7 0.2 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EFC40183.1 - 1.9e-17 63.8 0.0 2.1e-16 60.4 0.0 2.4 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC40183.1 - 2.2e-07 30.8 0.1 6.7e-07 29.3 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain NTPase_I-T PF01931.18 EFC40184.1 - 1.6e-53 180.9 0.1 1.8e-53 180.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF84 AT_hook PF02178.19 EFC40185.1 - 0.4 10.7 7.7 0.97 9.5 7.7 1.7 1 0 0 1 1 1 0 AT hook motif Cation_efflux PF01545.21 EFC40186.1 - 1.1e-11 44.9 12.7 6.4e-11 42.4 12.7 1.9 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFC40186.1 - 2.7e-09 37.0 0.0 6.8e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Peptidase_S10 PF00450.22 EFC40187.1 - 9.1e-101 338.3 1.4 9.1e-101 338.3 1.4 1.5 2 0 0 2 2 2 1 Serine carboxypeptidase His_biosynth PF00977.21 EFC40187.1 - 0.013 15.0 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein Ras PF00071.22 EFC40188.1 - 3e-10 40.0 0.0 5.7e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40188.1 - 8.2e-08 32.5 0.0 1.7e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Metallophos PF00149.28 EFC40188.1 - 0.0069 16.9 0.8 0.028 14.9 0.8 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_29 PF13555.6 EFC40188.1 - 0.019 14.7 0.0 0.041 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFC40188.1 - 0.22 12.0 0.4 0.56 10.7 0.3 1.6 1 1 0 1 1 1 0 ABC transporter Ion_trans PF00520.31 EFC40190.1 - 0.011 15.0 0.6 0.089 12.0 0.1 2.4 2 1 0 2 2 2 0 Ion transport protein DUF2207 PF09972.9 EFC40190.1 - 0.011 14.5 1.0 0.11 11.3 0.3 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF1198 PF06711.11 EFC40190.1 - 0.058 13.4 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) DUF3377 PF11857.8 EFC40190.1 - 0.073 13.0 0.1 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) bPH_3 PF14470.6 EFC40190.1 - 0.096 13.1 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial PH domain Pkinase PF00069.25 EFC40191.1 - 5e-45 153.9 0.0 5.5e-33 114.5 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40191.1 - 2.4e-43 148.3 0.0 4.1e-43 147.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Beta_helix PF13229.6 EFC40191.1 - 4.4e-25 88.4 28.7 1.9e-14 53.8 9.9 3.4 3 1 1 4 4 4 2 Right handed beta helix region NosD PF05048.13 EFC40191.1 - 2e-15 56.8 19.3 3.8e-10 39.5 5.5 3.3 1 1 1 3 3 3 2 Periplasmic copper-binding protein (NosD) APH PF01636.23 EFC40191.1 - 0.016 15.2 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Guanylate_cyc PF00211.20 EFC40192.1 - 4e-50 170.0 0.0 7.3e-50 169.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40192.1 - 1e-12 48.2 0.3 3.2e-12 46.6 0.3 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC40192.1 - 1.4e-06 28.3 0.0 2.7e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 PAS fold DUF3377 PF11857.8 EFC40192.1 - 0.0013 18.6 7.1 0.0075 16.2 0.4 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF3377) PAS_8 PF13188.7 EFC40192.1 - 0.0083 16.1 0.0 0.04 14.0 0.0 2.1 2 0 0 2 2 2 1 PAS domain HNOBA PF07701.14 EFC40192.1 - 0.074 12.5 0.4 0.16 11.4 0.4 1.5 1 0 0 1 1 1 0 Heme NO binding associated YgaB PF14182.6 EFC40192.1 - 0.082 13.3 0.2 0.78 10.2 0.3 2.7 2 0 0 2 2 2 0 YgaB-like protein UCH PF00443.29 EFC40193.1 - 6.7e-37 127.4 0.8 8.7e-37 127.0 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC40193.1 - 1.2e-17 64.5 0.7 1.9e-17 63.9 0.7 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RecG_N PF17190.4 EFC40194.1 - 0.0091 16.7 0.7 0.0091 16.7 0.7 1.9 2 0 0 2 2 2 1 RecG N-terminal helical domain AAA_23 PF13476.6 EFC40194.1 - 0.44 11.0 4.9 0.57 10.7 4.9 1.1 1 0 0 1 1 1 0 AAA domain ALS_ss_C PF10369.9 EFC40195.1 - 0.0066 16.6 0.2 0.0098 16.1 0.2 1.3 1 0 0 1 1 1 1 Small subunit of acetolactate synthase CRS1_YhbY PF01985.21 EFC40195.1 - 0.12 12.6 0.1 0.15 12.2 0.1 1.4 1 1 0 1 1 1 0 CRS1 / YhbY (CRM) domain Pirin PF02678.16 EFC40196.1 - 1.6e-28 98.8 0.1 7e-28 96.8 0.1 1.9 2 0 0 2 2 2 1 Pirin Cupin_2 PF07883.11 EFC40196.1 - 2.4e-06 27.1 0.1 1.8e-05 24.4 0.1 2.2 2 0 0 2 2 2 1 Cupin domain Pirin_C_2 PF17954.1 EFC40196.1 - 7.8e-06 26.0 0.0 0.00029 21.0 0.0 2.4 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain PH_4 PF15404.6 EFC40196.1 - 0.047 13.5 0.1 0.31 10.8 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain AAA PF00004.29 EFC40197.1 - 3.6e-48 163.3 0.0 2.1e-37 128.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC40197.1 - 2.8e-09 36.6 0.1 1.1e-08 34.7 0.1 2.0 1 1 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EFC40197.1 - 1.9e-07 31.4 1.9 0.012 15.9 0.6 3.7 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 EFC40197.1 - 1e-06 28.3 0.2 0.0046 16.2 0.1 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_2 PF07724.14 EFC40197.1 - 8.5e-06 26.0 0.0 0.00011 22.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EFC40197.1 - 1.7e-05 24.9 0.1 0.059 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EFC40197.1 - 6.2e-05 22.8 0.1 0.0088 15.8 0.0 2.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC40197.1 - 9.9e-05 22.4 0.0 0.00053 20.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) TsaE PF02367.17 EFC40197.1 - 0.00018 21.5 0.0 0.039 13.9 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EFC40197.1 - 0.0002 21.4 1.2 0.14 12.1 0.1 2.9 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 EFC40197.1 - 0.0002 20.8 0.0 0.00081 18.8 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 EFC40197.1 - 0.00036 20.3 0.1 0.0018 18.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC40197.1 - 0.00045 20.6 0.1 0.03 14.7 0.0 3.1 3 1 0 3 3 3 1 AAA ATPase domain AAA_3 PF07726.11 EFC40197.1 - 0.0012 18.7 0.0 0.0035 17.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFC40197.1 - 0.006 17.0 0.0 0.11 13.0 0.0 3.0 2 0 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 EFC40197.1 - 0.012 15.1 0.2 0.04 13.4 0.2 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region DNA_pol3_delta2 PF13177.6 EFC40197.1 - 0.014 15.2 0.0 4.4 7.1 0.0 2.8 2 0 0 2 2 2 0 DNA polymerase III, delta subunit IstB_IS21 PF01695.17 EFC40197.1 - 0.017 14.8 0.1 0.16 11.7 0.1 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Vps4_C PF09336.10 EFC40197.1 - 0.019 15.0 0.2 0.019 15.0 0.2 2.3 3 0 0 3 3 1 0 Vps4 C terminal oligomerisation domain Sigma54_activat PF00158.26 EFC40197.1 - 0.039 13.6 0.1 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_18 PF13238.6 EFC40197.1 - 0.044 14.3 0.0 0.23 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain CDC48_N PF02359.18 EFC40197.1 - 0.046 13.9 0.0 0.19 11.9 0.0 2.1 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain AAA_33 PF13671.6 EFC40197.1 - 0.063 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFC40197.1 - 0.067 13.1 0.1 1.1 9.1 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_19 PF13245.6 EFC40197.1 - 0.075 13.4 0.7 0.19 12.1 0.7 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFC40197.1 - 0.095 12.6 0.1 0.7 9.8 0.1 2.4 1 1 0 1 1 1 0 NACHT domain Parvo_NS1 PF01057.17 EFC40197.1 - 0.15 11.1 0.0 0.34 10.0 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 EFC40197.1 - 0.23 11.2 0.1 0.49 10.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFC40197.1 - 0.61 9.6 3.0 3 7.4 0.0 2.9 3 0 0 3 3 3 0 AAA domain Methyltransf_15 PF09445.10 EFC40198.1 - 1.8e-05 24.4 0.0 5.5e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase DUF4727 PF15856.5 EFC40199.1 - 0.059 13.0 0.1 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4727) Nup54_C PF18437.1 EFC40199.1 - 0.21 11.5 2.5 0.53 10.2 2.5 1.7 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain Syntaxin-6_N PF09177.11 EFC40199.1 - 0.81 10.3 13.2 1 9.9 1.0 4.1 4 0 0 4 4 4 0 Syntaxin 6, N-terminal TSC22 PF01166.18 EFC40199.1 - 8.6 6.8 6.8 4.5 7.7 0.2 3.5 3 0 0 3 3 3 0 TSC-22/dip/bun family Ribosomal_S2 PF00318.20 EFC40201.1 - 8.4e-25 87.3 6.1 7.5e-15 54.7 0.4 2.5 2 1 1 3 3 3 2 Ribosomal protein S2 SBP_bac_8 PF13416.6 EFC40201.1 - 0.00018 21.4 0.0 0.00023 21.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein PGM1_C PF18105.1 EFC40201.1 - 0.11 12.0 0.5 0.25 10.9 0.5 1.5 1 0 0 1 1 1 0 PGM1 C-terminal domain Pecanex_C PF05041.15 EFC40202.1 - 1.3e-84 283.3 0.1 2e-84 282.7 0.1 1.3 1 0 0 1 1 1 1 Pecanex protein (C-terminus) Sbi-IV PF11621.8 EFC40203.1 - 0.078 13.3 1.0 0.16 12.4 0.1 1.9 2 0 0 2 2 2 0 C3 binding domain 4 of IgG-bind protein SBI Helicase_C PF00271.31 EFC40204.1 - 1.3e-10 41.6 2.3 2.7e-10 40.6 0.1 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain SUV3_C PF12513.8 EFC40204.1 - 4.6e-10 39.3 2.7 4.6e-10 39.3 2.7 2.3 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal AAA_22 PF13401.6 EFC40204.1 - 0.0001 22.6 0.1 0.00058 20.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Suv3_C_1 PF18147.1 EFC40204.1 - 0.00039 20.2 0.0 0.00077 19.3 0.0 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 TK PF00265.18 EFC40204.1 - 0.011 15.6 0.2 0.17 11.7 0.0 2.8 3 0 0 3 3 3 0 Thymidine kinase PhoH PF02562.16 EFC40204.1 - 0.04 13.4 0.0 0.15 11.5 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 EFC40204.1 - 0.1 12.6 0.7 0.46 10.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF29 PF01724.16 EFC40204.1 - 1.6 9.0 5.6 0.43 10.8 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF29 DUF4476 PF14771.6 EFC40205.1 - 1.2e-20 73.6 7.4 2.8e-15 56.4 1.4 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) InPase PF18823.1 EFC40205.1 - 0.023 14.4 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Inorganic Pyrophosphatase FAM75 PF14650.6 EFC40205.1 - 0.78 9.2 15.2 1.3 8.5 15.2 1.3 1 0 0 1 1 1 0 FAM75 family LRR_6 PF13516.6 EFC40206.1 - 2.8e-42 139.2 4.8 0.00012 21.9 0.0 8.4 8 0 0 8 8 8 8 Leucine Rich repeat LRR_8 PF13855.6 EFC40206.1 - 1.4e-25 88.8 16.5 2.4e-07 30.4 0.6 4.7 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC40206.1 - 3.1e-19 68.7 17.9 8.6e-05 22.8 0.1 6.0 2 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40206.1 - 3.5e-14 51.2 0.0 25 5.9 0.0 8.9 9 0 0 9 9 9 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC40206.1 - 3.8e-05 23.3 0.9 0.11 12.0 0.1 3.1 1 1 2 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC40206.1 - 0.0056 16.6 0.8 17 5.2 0.0 4.9 1 1 5 6 6 6 1 Domain of unknown function (DUF4347) Spidroin_N PF16763.5 EFC40206.1 - 0.013 15.5 4.4 77 3.3 0.0 6.2 3 2 4 7 7 7 0 Major ampullate spidroin 1, spider silk protein 1, N-term ApoB100_C PF12491.8 EFC40206.1 - 0.026 14.5 15.2 22 5.1 0.1 7.9 4 2 4 9 9 9 0 Apolipoprotein B100 C terminal Dynein_heavy PF03028.15 EFC40206.1 - 0.083 13.0 0.2 0.17 12.0 0.2 1.5 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain Beta_helix PF13229.6 EFC40206.1 - 6.3 6.6 19.7 23 4.8 7.1 3.1 1 1 1 2 2 2 0 Right handed beta helix region EGF_2 PF07974.13 EFC40207.1 - 2e-37 127.2 241.8 0.00012 22.3 9.4 14.9 15 0 0 15 15 15 14 EGF-like domain EGF PF00008.27 EFC40207.1 - 3.8e-06 27.1 160.7 0.0088 16.3 7.0 15.0 14 0 0 14 14 14 11 EGF-like domain NHL PF01436.21 EFC40207.1 - 0.0056 16.7 0.0 0.3 11.2 0.0 3.7 3 0 0 3 3 3 1 NHL repeat ABC_membrane PF00664.23 EFC40208.1 - 9.3e-44 150.1 11.3 2.4e-42 145.5 11.3 2.1 1 1 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC40208.1 - 1.3e-36 126.1 0.3 2.9e-36 125.0 0.3 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC40208.1 - 3.7e-05 23.3 4.6 0.0013 18.2 4.6 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 EFC40208.1 - 0.0013 18.5 1.4 0.0076 16.0 1.4 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFC40208.1 - 0.0014 18.3 0.1 0.003 17.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC40208.1 - 0.004 17.6 0.4 0.012 16.0 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain G-alpha PF00503.20 EFC40208.1 - 0.02 14.1 0.1 0.064 12.4 0.0 1.8 2 0 0 2 2 2 0 G-protein alpha subunit Zeta_toxin PF06414.12 EFC40208.1 - 0.021 14.1 0.0 0.058 12.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin ABC_ATPase PF09818.9 EFC40208.1 - 0.025 13.4 1.4 0.031 13.1 0.0 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class SbcCD_C PF13558.6 EFC40208.1 - 0.046 14.0 0.3 0.43 10.8 0.3 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Semialdhyde_dhC PF02774.18 EFC40208.1 - 0.16 12.0 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, dimerisation domain AAA_22 PF13401.6 EFC40208.1 - 0.3 11.3 1.1 3.3 8.0 1.1 2.5 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EFC40208.1 - 0.39 10.4 1.5 0.32 10.6 0.1 1.6 2 0 0 2 2 2 0 AAA ATPase domain SR-25 PF10500.9 EFC40209.1 - 0.041 13.5 7.0 0.054 13.1 7.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LRR_6 PF13516.6 EFC40210.1 - 3e-46 151.6 2.9 5.8e-05 22.8 0.0 9.6 10 0 0 10 10 10 8 Leucine Rich repeat LRR_8 PF13855.6 EFC40210.1 - 2.7e-26 91.1 17.2 5.7e-06 26.0 0.1 5.6 2 1 5 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC40210.1 - 2.4e-23 81.8 8.9 0.001 19.4 0.0 6.5 2 1 5 8 8 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40210.1 - 1.6e-14 52.2 2.0 4.7 8.2 0.0 9.4 11 0 0 11 11 10 1 Leucine Rich Repeat PulA_N1 PF17999.1 EFC40210.1 - 0.0022 18.7 4.9 0.22 12.3 0.4 3.8 2 2 2 4 4 4 1 Pullulanase N1-terminal domain DUF4347 PF14252.6 EFC40210.1 - 0.0067 16.3 0.3 89 2.9 0.0 5.5 1 1 4 6 6 6 0 Domain of unknown function (DUF4347) Cas6 PF09559.10 EFC40210.1 - 0.012 15.6 2.1 0.1 12.5 0.2 2.5 1 1 1 3 3 3 0 Cas6 Crispr AlphaC_N PF08829.10 EFC40210.1 - 0.02 14.9 1.3 11 6.1 0.1 3.4 1 1 3 4 4 4 0 Alpha C protein N terminal Spidroin_N PF16763.5 EFC40210.1 - 0.022 14.8 4.9 45 4.1 0.0 5.7 4 2 4 8 8 8 0 Major ampullate spidroin 1, spider silk protein 1, N-term Dynein_heavy PF03028.15 EFC40210.1 - 0.022 14.8 0.4 0.05 13.7 0.4 1.5 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain PapC_C PF13953.6 EFC40210.1 - 0.2 11.5 0.2 23 4.9 0.0 3.8 3 1 1 4 4 4 0 PapC C-terminal domain HGTP_anticodon PF03129.20 EFC40211.1 - 9.4e-16 57.8 0.3 1.4e-14 54.0 0.1 2.6 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFC40211.1 - 1.3 8.9 4.3 3.3 7.6 3.1 2.5 2 1 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) Patatin PF01734.22 EFC40212.1 - 1.5e-22 80.8 0.0 3.6e-22 79.6 0.0 1.7 1 1 0 1 1 1 1 Patatin-like phospholipase DUF4672 PF15716.5 EFC40212.1 - 0.17 11.5 2.3 0.34 10.5 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) DUF3456 PF11938.8 EFC40212.1 - 0.22 12.0 3.7 0.21 12.1 1.5 2.2 2 0 0 2 2 2 0 TLR4 regulator and MIR-interacting MSAP Trypsin PF00089.26 EFC40213.1 - 3.5e-28 98.9 0.0 4e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin BESS PF02944.20 EFC40213.1 - 0.2 11.5 0.1 0.35 10.8 0.1 1.3 1 0 0 1 1 1 0 BESS motif LapA_dom PF06305.11 EFC40214.1 - 0.021 14.6 0.1 0.021 14.6 0.1 2.6 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain GTP_EFTU PF00009.27 EFC40215.1 - 1.6e-58 197.5 0.1 5.1e-58 195.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFC40215.1 - 3.3e-21 75.1 0.0 9.2e-21 73.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFC40215.1 - 6e-20 71.2 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EFC40215.1 - 9.6e-13 48.0 0.0 2.1e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFC40215.1 - 1.1e-10 41.8 0.0 3e-10 40.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFC40215.1 - 0.00081 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFC40215.1 - 0.0075 16.4 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MycE_N PF17843.1 EFC40215.1 - 0.13 12.8 0.1 30 5.1 0.0 2.5 2 0 0 2 2 2 0 MycE methyltransferase N-terminal DUF2505 PF10698.9 EFC40216.1 - 0.00055 20.1 0.0 0.00099 19.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2505) PI31_Prot_C PF08577.11 EFC40217.1 - 8.1e-13 49.4 8.7 1.8e-12 48.2 8.7 1.6 1 0 0 1 1 1 1 PI31 proteasome regulator G-alpha PF00503.20 EFC40218.1 - 6.6e-31 107.7 1.9 9.3e-31 107.3 1.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 EFC40218.1 - 0.00074 19.7 0.1 0.21 11.8 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40218.1 - 0.00084 18.8 0.0 0.004 16.6 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC40218.1 - 0.0011 19.1 0.1 0.057 13.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EFC40218.1 - 0.0039 16.8 0.1 2 8.0 0.1 2.4 2 0 0 2 2 2 2 Ras family RCC1 PF00415.18 EFC40219.1 - 1.4e-43 147.3 2.7 1.1e-14 54.8 0.1 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC40219.1 - 6.5e-16 57.7 20.6 2.5e-06 27.1 1.3 4.9 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC40219.1 - 0.14 12.4 0.7 24 5.2 0.0 3.6 4 0 0 4 4 4 0 Putative heavy-metal chelation Nt_Gln_amidase PF09764.9 EFC40220.1 - 1.5e-39 135.5 0.1 1.8e-39 135.3 0.1 1.1 1 0 0 1 1 1 1 N-terminal glutamine amidase SET PF00856.28 EFC40221.1 - 1.4e-21 77.6 1.0 3.1e-21 76.5 0.3 1.9 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 EFC40221.1 - 2.3e-14 54.0 11.9 5.1e-13 49.6 5.2 2.6 2 0 0 2 2 2 2 Pre-SET motif F-box-like PF12937.7 EFC40221.1 - 0.0013 18.6 2.6 0.002 18.0 1.0 2.1 2 0 0 2 2 2 1 F-box-like Ras PF00071.22 EFC40222.1 - 1.4e-25 89.8 0.1 2.8e-25 88.8 0.1 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40222.1 - 2.1e-13 50.5 0.0 4.7e-13 49.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC40222.1 - 1.4e-08 34.6 0.0 2.7e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC40222.1 - 3e-08 33.3 0.2 9.8e-08 31.6 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC40222.1 - 1.8e-05 24.2 0.4 3.2e-05 23.4 0.4 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFC40222.1 - 2.4e-05 24.3 0.1 0.18 11.7 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EFC40222.1 - 0.0011 18.2 2.4 0.053 12.7 0.0 2.6 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC40222.1 - 0.0047 17.0 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC40222.1 - 0.02 14.7 0.1 0.087 12.6 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MCM PF00493.23 EFC40222.1 - 0.028 13.5 0.0 0.056 12.5 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 EFC40222.1 - 0.11 12.3 0.2 0.52 10.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain LPP20 PF02169.16 EFC40222.1 - 1.8 9.0 3.7 1.7 9.0 1.2 2.0 2 0 0 2 2 2 0 LPP20 lipoprotein RNA_polI_A34 PF08208.11 EFC40223.1 - 0.043 13.9 9.8 0.18 11.8 0.4 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Peptidase_S49_N PF08496.10 EFC40223.1 - 1.3 9.1 7.6 6.8 6.7 1.9 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal vATP-synt_AC39 PF01992.16 EFC40224.1 - 2.4e-88 296.9 3.3 2.7e-88 296.7 3.3 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Ank_2 PF12796.7 EFC40225.1 - 6.8e-28 97.1 6.3 9.8e-08 32.5 0.0 4.5 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC40225.1 - 2.9e-22 78.4 0.2 0.0051 17.1 0.0 6.6 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC40225.1 - 6.1e-21 74.5 2.4 0.00081 19.9 0.1 7.0 3 2 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC40225.1 - 4.9e-17 60.3 3.8 0.002 18.4 0.0 7.9 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 EFC40225.1 - 4.2e-15 55.4 0.3 0.039 14.4 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat START PF01852.19 EFC40225.1 - 1e-08 34.8 0.0 2e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 START domain RGS PF00615.19 EFC40225.1 - 8.1e-07 29.3 7.7 8.1e-07 29.3 7.7 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF4116 PF13475.6 EFC40226.1 - 5.6e-28 96.4 13.0 1.3e-09 37.6 0.0 6.6 2 2 6 8 8 8 7 Domain of unknown function (DUF4116) DUF1016_N PF17761.1 EFC40226.1 - 0.0012 19.0 0.6 0.0042 17.2 0.0 2.2 2 1 0 2 2 2 1 DUF1016 N-terminal domain Importin_rep_3 PF18806.1 EFC40226.1 - 0.056 13.5 0.1 0.28 11.3 0.0 2.1 2 0 0 2 2 2 0 Importin 13 repeat GTP_EFTU PF00009.27 EFC40228.1 - 8.5e-05 22.2 0.2 9.4e-05 22.0 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Ras PF00071.22 EFC40228.1 - 0.012 15.2 0.3 0.017 14.7 0.3 1.1 1 0 0 1 1 1 0 Ras family MMR_HSR1_Xtn PF16897.5 EFC40228.1 - 0.025 14.6 0.4 0.099 12.7 0.4 1.9 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain LPP20 PF02169.16 EFC40228.1 - 0.17 12.2 1.2 0.27 11.6 1.2 1.3 1 0 0 1 1 1 0 LPP20 lipoprotein Mannosyl_trans2 PF04188.13 EFC40230.1 - 4.8e-61 207.4 27.7 5.5e-61 207.2 27.7 1.0 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) Mut7-C PF01927.16 EFC40231.1 - 3.1e-29 102.0 4.5 1.8e-28 99.5 4.5 2.0 1 1 0 1 1 1 1 Mut7-C RNAse domain E6 PF00518.17 EFC40231.1 - 0.026 15.0 0.3 0.071 13.6 0.3 1.8 1 0 0 1 1 1 0 Early Protein (E6) Spore_coat_CotO PF14153.6 EFC40231.1 - 0.53 10.2 18.3 0.017 15.0 7.4 2.2 2 0 0 2 2 2 0 Spore coat protein CotO ARL2_Bind_BART PF11527.8 EFC40232.1 - 0.18 11.9 4.1 0.18 11.9 0.6 2.6 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART Pkinase PF00069.25 EFC40233.1 - 3.2e-56 190.6 3.6 4.7e-56 190.1 3.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40233.1 - 1.2e-32 113.2 0.4 2.2e-32 112.4 0.4 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC40233.1 - 4.7e-17 61.1 9.0 8.1e-05 22.5 0.1 6.7 6 0 0 6 6 6 4 NHL repeat Pkinase_fungal PF17667.1 EFC40233.1 - 1.1e-06 27.7 0.1 1.8e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EFC40233.1 - 2.4e-06 27.5 0.2 5e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 TMEM154 protein family YrbL-PhoP_reg PF10707.9 EFC40233.1 - 0.0001 21.9 0.3 0.00028 20.5 0.3 1.7 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL EGF_2 PF07974.13 EFC40233.1 - 0.00099 19.4 12.3 0.002 18.4 12.3 1.6 1 0 0 1 1 1 1 EGF-like domain Arylesterase PF01731.20 EFC40233.1 - 0.018 15.2 0.2 0.6 10.3 0.0 3.6 1 1 1 2 2 2 0 Arylesterase Kdo PF06293.14 EFC40233.1 - 0.043 13.2 0.2 0.079 12.3 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFC40233.1 - 0.062 12.9 0.2 0.14 11.8 0.2 1.5 1 0 0 1 1 1 0 RIO1 family FixQ PF05545.11 EFC40233.1 - 0.095 12.7 0.3 0.25 11.3 0.3 1.7 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF5074 PF16819.5 EFC40233.1 - 0.17 11.9 5.0 1.1 9.4 0.0 4.9 6 0 0 6 6 6 0 Domain of unknown function (DUF5074) ECSCR PF15820.5 EFC40233.1 - 0.25 11.2 2.5 0.59 10.0 2.5 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator hEGF PF12661.7 EFC40233.1 - 0.25 12.0 7.8 0.73 10.6 7.8 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF DUF3377 PF11857.8 EFC40233.1 - 0.77 9.7 4.8 1.9 8.5 4.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) SKG6 PF08693.10 EFC40233.1 - 5 6.6 7.8 11 5.5 7.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Kelch_6 PF13964.6 EFC40235.1 - 2e-26 91.3 1.9 6.7e-07 29.4 0.0 5.9 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFC40235.1 - 2.6e-24 84.5 0.3 3.2e-07 29.8 0.0 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 EFC40235.1 - 3.3e-22 78.2 0.0 2.2e-07 30.8 0.0 5.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC40235.1 - 1.3e-21 76.2 0.1 6.2e-07 29.3 0.0 4.8 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EFC40235.1 - 3.2e-21 74.4 2.3 5e-06 26.3 0.0 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 EFC40235.1 - 1.2e-18 66.9 0.0 1.4e-05 25.2 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain DUF5074 PF16819.5 EFC40235.1 - 0.67 10.0 7.9 0.5 10.4 0.1 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF5074) Bcl-2 PF00452.19 EFC40236.1 - 0.0088 16.7 0.5 0.029 15.0 0.1 2.0 2 0 0 2 2 2 1 Apoptosis regulator proteins, Bcl-2 family Ras PF00071.22 EFC40237.1 - 3.3e-31 108.1 0.0 4.9e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40237.1 - 4.1e-15 56.0 0.0 8.8e-15 55.0 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40237.1 - 1.7e-06 27.6 0.3 1.8e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family F-box PF00646.33 EFC40237.1 - 0.0052 16.6 0.5 0.012 15.5 0.5 1.6 1 0 0 1 1 1 1 F-box domain AAA_7 PF12775.7 EFC40237.1 - 0.032 13.7 0.0 0.057 12.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 EFC40237.1 - 0.11 12.0 0.0 0.24 10.8 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit SprT-like PF10263.9 EFC40238.1 - 4.3e-19 68.5 0.2 8.9e-19 67.4 0.2 1.6 1 0 0 1 1 1 1 SprT-like family Chromo PF00385.24 EFC40238.1 - 7.7e-14 51.3 4.7 2.9e-13 49.5 4.7 2.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Zn_ribbon_SprT PF17283.2 EFC40238.1 - 4.8e-08 32.8 1.9 1.2e-07 31.5 1.9 1.7 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 EFC40238.1 - 1.3e-05 25.5 0.5 1.3e-05 25.5 0.5 2.8 4 0 0 4 4 4 1 HMG (high mobility group) box YABBY PF04690.13 EFC40238.1 - 0.0073 16.9 0.1 0.0073 16.9 0.1 3.8 2 2 1 4 4 4 1 YABBY protein L51_S25_CI-B8 PF05047.16 EFC40238.1 - 0.037 13.9 0.7 0.53 10.3 0.3 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Tudor-knot PF11717.8 EFC40238.1 - 0.04 13.8 5.8 0.029 14.3 3.3 2.0 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Zn-ribbon_8 PF09723.10 EFC40238.1 - 0.048 13.8 0.6 0.17 12.0 0.6 2.0 1 0 0 1 1 1 0 Zinc ribbon domain DUF3246 PF11596.8 EFC40238.1 - 1.6 8.1 12.8 1.4 8.3 8.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Phospholip_B PF04916.13 EFC40239.1 - 4.6e-159 530.4 5.2 5.8e-159 530.1 5.2 1.0 1 0 0 1 1 1 1 Phospholipase B SLC3A2_N PF16028.5 EFC40239.1 - 0.011 15.3 0.1 0.057 13.0 0.0 2.2 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus LRR_8 PF13855.6 EFC40240.1 - 1.4e-16 60.0 32.5 3.5e-06 26.7 0.9 5.6 3 2 1 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 EFC40240.1 - 9.5e-10 37.7 21.2 0.025 14.6 0.1 8.9 9 1 1 10 10 10 3 Leucine Rich repeat LRR_4 PF12799.7 EFC40240.1 - 2.9e-05 24.4 46.7 0.0033 17.8 4.3 8.1 1 1 4 7 7 7 4 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC40240.1 - 0.00024 20.9 0.2 0.00059 19.7 0.0 1.8 2 0 0 2 2 2 1 F-box-like LRR_9 PF14580.6 EFC40240.1 - 0.0007 19.1 3.5 0.0007 19.1 3.5 3.6 1 1 3 4 4 4 1 Leucine-rich repeat LRR_1 PF00560.33 EFC40240.1 - 0.018 15.5 23.9 17 6.4 0.1 8.2 8 1 0 8 8 8 0 Leucine Rich Repeat F-box PF00646.33 EFC40240.1 - 0.021 14.7 0.2 0.18 11.7 0.0 2.5 3 0 0 3 3 3 0 F-box domain DUF4116 PF13475.6 EFC40241.1 - 1.2e-25 89.0 20.6 1.9e-08 33.9 0.7 6.4 4 2 3 7 7 7 7 Domain of unknown function (DUF4116) B2 PF11473.8 EFC40241.1 - 0.0088 15.8 0.0 0.87 9.4 0.0 3.2 2 1 1 3 3 3 1 RNA binding protein B2 RGS PF00615.19 EFC40242.1 - 2.7e-12 47.0 0.4 2.7e-12 47.0 0.4 2.2 3 0 0 3 3 3 1 Regulator of G protein signaling domain RdRP PF05183.12 EFC40243.1 - 1.3e-60 205.7 2.5 2.1e-60 205.0 2.5 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase LRR_6 PF13516.6 EFC40244.1 - 2.4e-19 67.7 2.5 2.1e-05 24.2 0.0 4.4 4 1 0 4 4 4 4 Leucine Rich repeat LRR_4 PF12799.7 EFC40244.1 - 4.9e-11 42.7 2.1 4.8e-05 23.7 0.1 3.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC40244.1 - 4.2e-10 39.2 2.7 9.2e-06 25.3 0.6 2.1 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 EFC40244.1 - 1.2e-05 25.1 0.0 6.5 7.7 0.0 4.1 4 0 0 4 4 4 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC40244.1 - 0.0055 16.2 0.1 1.1 8.8 0.0 2.0 1 1 1 2 2 2 2 Leucine-rich repeat UPF0193 PF05250.11 EFC40244.1 - 0.026 14.4 1.3 0.17 11.7 0.4 2.1 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0193) DUF5490 PF17593.2 EFC40244.1 - 0.11 12.5 0.0 36 4.5 0.0 3.1 3 1 1 4 4 4 0 Family of unknown function (DUF5490) ApoB100_C PF12491.8 EFC40244.1 - 0.13 12.3 0.7 4.9 7.2 0.1 3.2 1 1 2 3 3 3 0 Apolipoprotein B100 C terminal RapA_C PF12137.8 EFC40244.1 - 0.14 11.2 0.0 2.1 7.3 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase recycling family C-terminal LRR_6 PF13516.6 EFC40245.1 - 4.4e-36 119.9 7.9 1.4e-05 24.7 0.1 8.4 8 0 0 8 8 8 7 Leucine Rich repeat LRR_4 PF12799.7 EFC40245.1 - 2.7e-25 88.0 4.0 1.2e-05 25.6 0.1 4.9 2 1 2 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC40245.1 - 2.1e-22 78.6 11.8 2e-07 30.6 0.2 4.0 2 1 3 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 EFC40245.1 - 5.4e-10 38.4 2.3 16 6.5 0.0 8.0 8 1 0 8 8 8 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC40245.1 - 2.3e-07 30.5 0.6 0.014 14.9 0.0 3.4 1 1 2 3 3 3 3 Leucine-rich repeat UPF0193 PF05250.11 EFC40245.1 - 0.025 14.4 8.7 0.27 11.0 0.2 3.7 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0193) eIF2A PF08662.11 EFC40246.1 - 6.7e-53 179.5 1.4 3.6e-52 177.1 0.1 2.8 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Pallilysin PF18663.1 EFC40246.1 - 0.11 12.4 0.1 0.44 10.5 0.1 2.1 1 1 0 1 1 1 0 Pallilysin beta barrel domain TPR_2 PF07719.17 EFC40248.1 - 1e-11 44.0 9.9 0.035 14.2 0.3 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40248.1 - 1.3e-08 34.3 8.6 0.047 13.5 0.0 6.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40248.1 - 0.00036 20.5 16.7 1.1 9.6 1.6 5.8 5 0 0 5 5 5 3 Tetratricopeptide repeat DUF4116 PF13475.6 EFC40249.1 - 4e-55 183.3 33.2 4.9e-10 39.0 0.2 10.5 6 3 5 11 11 11 10 Domain of unknown function (DUF4116) TPR_2 PF07719.17 EFC40250.1 - 1.7e-10 40.2 2.0 0.0091 16.0 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40250.1 - 1e-08 35.3 0.3 1.6e-05 25.1 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40250.1 - 1.1e-07 31.3 7.2 0.00079 19.1 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC40250.1 - 0.0005 19.9 2.5 1.1 9.2 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC40250.1 - 0.0017 18.4 0.0 0.016 15.4 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40250.1 - 0.012 15.3 4.6 3.8 7.3 0.0 5.0 6 0 0 6 6 6 0 TPR repeat TPR_8 PF13181.6 EFC40250.1 - 0.023 14.9 4.3 0.51 10.7 0.0 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC40250.1 - 0.023 14.4 0.3 0.023 14.4 0.3 2.3 3 0 0 3 3 3 0 26S proteasome subunit RPN7 Dis3l2_C_term PF17877.1 EFC40251.1 - 0.15 12.4 1.2 0.57 10.5 1.2 2.0 1 0 0 1 1 1 0 DIS3-like exonuclease 2 C terminal Dickkopf_N PF04706.12 EFC40252.1 - 0.042 14.3 0.5 0.042 14.3 0.5 2.5 2 0 0 2 2 2 0 Dickkopf N-terminal cysteine-rich region EB PF01683.18 EFC40252.1 - 1.4 9.3 15.6 1.8 8.9 5.3 2.3 1 1 1 2 2 2 0 EB module Ras PF00071.22 EFC40254.1 - 2.5e-13 49.9 0.1 5.2e-13 48.9 0.1 1.5 1 1 0 1 1 1 1 Ras family F-box PF00646.33 EFC40254.1 - 0.00012 21.8 0.2 0.00036 20.3 0.2 1.8 1 0 0 1 1 1 1 F-box domain Roc PF08477.13 EFC40254.1 - 0.004 17.4 0.0 0.0072 16.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC40254.1 - 0.11 12.4 0.2 0.27 11.2 0.2 1.7 1 0 0 1 1 1 0 F-box-like EGF_2 PF07974.13 EFC40255.1 - 3e-16 59.5 104.5 0.00044 20.6 12.2 7.1 7 0 0 7 7 7 6 EGF-like domain GPS PF01825.21 EFC40255.1 - 1.1e-08 35.4 7.5 1.1e-08 35.4 7.5 2.8 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif RGS PF00615.19 EFC40255.1 - 3.3e-05 24.1 1.9 3.3e-05 24.1 1.9 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain Chordopox_A13L PF05961.11 EFC40255.1 - 0.18 12.1 4.6 1.4 9.2 0.7 3.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Suv3_N PF18114.1 EFC40256.1 - 0.048 13.8 1.0 0.49 10.5 0.6 2.8 2 0 0 2 2 2 0 Suv3 helical N-terminal domain LMBR1 PF04791.16 EFC40259.1 - 0.18 10.7 5.4 0.2 10.5 5.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exo_endo_phos_2 PF14529.6 EFC40260.1 - 9.7e-05 22.2 0.7 9.7e-05 22.2 0.7 2.4 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Cast PF10174.9 EFC40260.1 - 0.002 16.5 3.0 0.0036 15.6 3.0 1.3 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone L27 PF02828.16 EFC40260.1 - 0.13 12.1 0.3 0.28 11.0 0.3 1.5 1 0 0 1 1 1 0 L27 domain COesterase PF00135.28 EFC40261.1 - 2.1e-97 327.1 0.9 2.5e-97 326.9 0.9 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFC40261.1 - 7.2e-07 29.3 0.0 0.0039 17.1 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC40261.1 - 0.0023 17.4 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family LRR_8 PF13855.6 EFC40262.1 - 5.9e-26 90.0 14.0 1.4e-10 40.7 1.0 4.3 3 2 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC40262.1 - 5.1e-23 80.8 26.2 2.2e-06 27.9 1.2 7.7 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC40262.1 - 1.5e-22 77.7 22.5 0.01 15.8 0.1 9.6 9 0 0 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.33 EFC40262.1 - 2.1e-11 42.7 13.7 4.5 8.2 0.4 10.0 10 0 0 10 10 10 3 Leucine Rich Repeat F-box-like PF12937.7 EFC40262.1 - 0.0071 16.2 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC40262.1 - 0.049 13.5 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 F-box domain Beta_helix PF13229.6 EFC40262.1 - 0.14 12.0 7.7 0.35 10.7 3.4 2.6 2 1 2 4 4 4 0 Right handed beta helix region Guanylate_cyc PF00211.20 EFC40264.1 - 3e-52 176.9 0.2 5.9e-52 175.9 0.2 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40264.1 - 2.1e-13 50.4 0.1 7.5e-13 48.6 0.1 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC40264.1 - 1.5e-05 25.0 0.1 7e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold dsDNA_bind PF01984.20 EFC40264.1 - 0.0076 16.5 0.1 0.022 15.0 0.1 1.8 1 0 0 1 1 1 1 Double-stranded DNA-binding domain HNOBA PF07701.14 EFC40264.1 - 0.0091 15.4 0.9 0.02 14.3 0.2 2.0 2 0 0 2 2 2 1 Heme NO binding associated TM_helix PF05552.12 EFC40264.1 - 0.099 12.6 3.8 0.82 9.7 0.2 2.7 2 0 0 2 2 2 0 Conserved TM helix UNC45-central PF11701.8 EFC40264.1 - 0.1 12.5 0.9 2.9 7.9 0.2 2.8 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central Peptidase_C1 PF00112.23 EFC40265.1 - 1.2e-37 130.1 1.1 1.5e-37 129.8 1.1 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Glyco_hydro_19 PF00182.19 EFC40266.1 - 9.3e-15 55.1 0.5 4.2e-14 53.0 0.4 2.1 1 1 1 2 2 2 1 Chitinase class I SH3_3 PF08239.11 EFC40266.1 - 2.9e-06 27.5 0.2 7.2e-06 26.2 0.1 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain MAPEG PF01124.18 EFC40267.1 - 1.8e-11 44.1 0.4 2.8e-11 43.4 0.4 1.3 1 0 0 1 1 1 1 MAPEG family TIC20 PF16166.5 EFC40267.1 - 0.89 9.3 8.0 1.4 8.7 8.0 1.3 1 0 0 1 1 1 0 Chloroplast import apparatus Tic20-like RWP-RK PF02042.15 EFC40268.1 - 8.4e-07 28.9 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 RWP-RK domain AARP2CN PF08142.12 EFC40268.1 - 0.079 13.1 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 AARP2CN (NUC121) domain DUF4773 PF15998.5 EFC40269.1 - 0.0024 18.4 0.1 0.0039 17.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4773) TPR_2 PF07719.17 EFC40270.1 - 5e-28 94.9 9.9 2.5e-05 24.0 0.2 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40270.1 - 2.5e-26 90.4 11.4 4.2e-06 26.4 1.0 8.0 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40270.1 - 3.7e-19 68.1 3.5 4.1e-06 26.4 0.5 7.7 5 2 3 8 8 8 3 TPR repeat TPR_12 PF13424.6 EFC40270.1 - 2.3e-18 66.2 9.4 1.5e-05 25.2 0.1 6.1 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40270.1 - 1.9e-15 56.0 7.6 0.00044 20.4 0.0 6.6 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40270.1 - 1.6e-14 52.8 14.9 0.042 14.1 0.3 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40270.1 - 2.6e-11 43.9 0.0 0.0014 19.1 0.1 4.4 2 2 2 4 4 4 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC40270.1 - 7.7e-11 42.1 10.0 0.00014 22.0 0.0 4.4 2 1 3 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFC40270.1 - 6.1e-10 39.1 0.2 1.1 10.2 0.0 6.0 3 2 4 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC40270.1 - 2.1e-09 37.9 0.0 0.0095 16.6 0.0 4.3 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40270.1 - 1.1e-08 34.5 5.3 0.84 9.8 0.0 7.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC40270.1 - 4.6e-08 32.7 6.5 0.023 14.6 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.8 EFC40270.1 - 1.1e-05 24.6 3.0 0.046 12.6 0.0 3.7 3 1 1 4 4 4 2 NMDA receptor-regulated protein 1 Sel1 PF08238.12 EFC40270.1 - 1.3e-05 25.6 5.0 2.6 8.9 0.2 5.1 5 0 0 5 5 4 1 Sel1 repeat TPR_MalT PF17874.1 EFC40270.1 - 8.1e-05 22.1 0.3 0.77 9.1 0.0 4.1 2 1 2 4 4 4 1 MalT-like TPR region TPR_9 PF13371.6 EFC40270.1 - 0.00017 21.7 0.0 0.97 9.6 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC40270.1 - 0.0003 21.2 9.5 14 6.6 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFC40270.1 - 0.13 13.0 0.0 1.2 9.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4810 PF16068.5 EFC40270.1 - 0.16 12.5 7.7 69 4.1 0.0 5.5 5 1 0 5 5 5 0 Domain of unknown function (DUF4810) HTH_Bact PF18768.1 EFC40270.1 - 0.34 10.5 3.1 12 5.6 0.0 4.5 5 0 0 5 5 5 0 Helix-turn-helix bacterial domain MIT PF04212.18 EFC40270.1 - 0.73 9.9 9.5 3.3 7.9 0.1 5.5 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 EFC40270.1 - 3.3 7.8 8.1 3.7 7.6 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ICAP-1_inte_bdg PF10480.9 EFC40271.1 - 0.0079 16.2 0.1 0.01 15.8 0.1 1.2 1 0 0 1 1 1 1 Beta-1 integrin binding protein DUF4116 PF13475.6 EFC40272.1 - 4.6e-25 87.1 6.4 8.1e-10 38.3 0.1 5.3 4 2 1 5 5 5 4 Domain of unknown function (DUF4116) Imm6 PF14434.6 EFC40272.1 - 0.088 12.7 0.4 0.7 9.8 0.0 2.4 2 0 0 2 2 2 0 Immunity protein Imm6 SNF2_N PF00176.23 EFC40273.1 - 3.4e-44 151.0 3.4 1e-43 149.4 3.4 1.9 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC40273.1 - 2.3e-13 50.5 0.1 2.6e-12 47.0 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC40273.1 - 1e-12 48.4 0.8 1e-12 48.4 0.8 4.6 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFC40273.1 - 2.5e-05 24.1 1.3 0.28 11.0 0.0 2.7 1 1 1 2 2 2 2 DEAD/DEAH box helicase DUF2075 PF09848.9 EFC40273.1 - 0.0032 16.7 1.0 0.0032 16.7 1.0 3.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EFC40273.1 - 0.012 15.9 1.0 0.13 12.6 1.0 2.6 1 1 0 1 1 1 0 AAA domain RCC1_2 PF13540.6 EFC40274.1 - 5.1e-09 35.7 1.9 0.022 14.6 0.3 4.3 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC40274.1 - 1.8e-07 31.6 0.1 0.0049 17.5 0.0 3.7 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC40275.1 - 1.5e-15 57.5 6.2 0.00015 22.3 0.1 5.5 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC40275.1 - 5.2e-15 54.8 19.9 3e-06 26.9 0.1 6.4 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Nop PF01798.18 EFC40276.1 - 3.5e-49 167.4 0.8 3.5e-49 167.4 0.8 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin F-box-like PF12937.7 EFC40276.1 - 2.1e-05 24.3 3.7 6.7e-05 22.7 3.7 1.9 1 1 0 1 1 1 1 F-box-like NOP5NT PF08156.13 EFC40276.1 - 0.00032 21.0 1.0 0.00032 21.0 1.0 2.8 2 0 0 2 2 2 1 NOP5NT (NUC127) domain F-box PF00646.33 EFC40276.1 - 0.055 13.4 0.3 0.055 13.4 0.3 2.7 2 1 1 3 3 3 0 F-box domain SlyX PF04102.12 EFC40276.1 - 1.7 9.3 5.7 0.44 11.2 0.4 2.7 3 0 0 3 3 3 0 SlyX PARP PF00644.20 EFC40278.1 - 2.3e-13 50.2 0.0 8.2e-13 48.4 0.0 2.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain ART-PolyVal PF18760.1 EFC40278.1 - 0.019 16.0 1.5 0.18 12.8 0.0 2.9 2 2 1 3 3 3 0 ADP-Ribosyltransferase in polyvalent proteins DUF1264 PF06884.11 EFC40278.1 - 0.062 12.9 0.0 0.24 11.0 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1264) Rhodanese PF00581.20 EFC40279.1 - 0.0002 21.9 0.0 0.00055 20.4 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain F-box-like PF12937.7 EFC40279.1 - 0.00033 20.5 0.2 0.0026 17.6 0.1 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC40279.1 - 0.00037 20.3 0.1 0.0065 16.3 0.0 2.8 2 0 0 2 2 2 1 F-box domain DUF4116 PF13475.6 EFC40279.1 - 0.0025 17.5 3.0 0.0061 16.3 0.8 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4116) RGS PF00615.19 EFC40280.1 - 2.2e-14 53.7 2.4 2.2e-14 53.7 2.4 2.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain NleF_casp_inhib PF16809.5 EFC40281.1 - 0.13 12.1 0.3 0.21 11.5 0.3 1.2 1 0 0 1 1 1 0 NleF caspase inhibitor COesterase PF00135.28 EFC40283.1 - 1.6e-98 330.8 7.7 3.2e-98 329.8 7.7 1.5 1 0 0 1 1 1 1 Carboxylesterase family p450 PF00067.22 EFC40283.1 - 1.2e-73 248.5 2.0 2.1e-73 247.6 2.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Abhydrolase_3 PF07859.13 EFC40283.1 - 2.1e-06 27.7 0.2 0.0051 16.7 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold BTB_2 PF02214.22 EFC40284.1 - 3.7e-13 49.6 5.7 1.5e-07 31.6 0.6 3.5 2 1 0 2 2 2 2 BTB/POZ domain WWE PF02825.20 EFC40284.1 - 1.4e-09 38.4 0.4 4.4e-09 36.8 0.4 2.0 1 0 0 1 1 1 1 WWE domain Polbeta PF18765.1 EFC40284.1 - 0.054 13.6 0.0 0.24 11.5 0.0 2.1 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase GTP_EFTU_D3 PF03143.17 EFC40285.1 - 1.5e-10 41.3 0.3 2.8e-10 40.5 0.3 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 EFC40285.1 - 9.1e-09 35.1 0.0 1.1e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFC40285.1 - 3.2e-05 24.2 0.2 0.00069 19.9 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu domain 2 RNA_pol_3_Rpc31 PF11705.8 EFC40286.1 - 2.5 8.3 4.5 0.39 10.9 0.1 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PI-PLC-X PF00388.19 EFC40287.1 - 1.3e-55 187.0 0.0 5.9e-55 184.8 0.0 2.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFC40287.1 - 3.4e-27 95.1 0.1 7.7e-27 93.9 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_like PF09279.11 EFC40287.1 - 0.0075 16.7 0.2 0.026 15.0 0.2 1.9 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like DUF4298 PF14131.6 EFC40287.1 - 3.3 7.7 7.2 9.1 6.3 0.2 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4298) SHOCT PF09851.9 EFC40288.1 - 1.7e-46 154.8 53.5 5.4e-07 29.1 1.2 10.4 10 0 0 10 10 10 9 Short C-terminal domain GvpG PF05120.12 EFC40288.1 - 4.9e-12 45.7 50.6 0.00094 19.1 2.5 9.8 5 3 5 10 10 10 5 Gas vesicle protein G DUF1707 PF08044.11 EFC40288.1 - 1.9e-06 27.8 0.0 24 5.1 0.0 7.2 9 0 0 9 9 8 0 Domain of unknown function (DUF1707) DMAP_binding PF06464.11 EFC40288.1 - 2e-05 25.4 59.8 0.0063 17.3 4.8 7.4 3 2 3 7 7 6 4 DMAP1-binding Domain Phage_XkdX PF09693.10 EFC40288.1 - 4.2e-05 23.5 7.5 3.9 7.6 0.0 7.3 8 1 1 9 9 9 1 Phage uncharacterised protein (Phage_XkdX) hnRNP_Q_AcD PF18360.1 EFC40288.1 - 0.0033 17.4 0.6 8.2 6.5 0.0 4.9 5 0 0 5 5 5 1 Heterogeneous nuclear ribonucleoprotein Q acidic domain Transposase_1 PF01359.18 EFC40288.1 - 0.13 12.1 2.0 8 6.4 0.4 3.4 2 0 0 2 2 2 0 Transposase (partial DDE domain) RST PF12174.8 EFC40288.1 - 0.13 12.2 4.7 4.2 7.4 0.0 3.7 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain HTH_38 PF13936.6 EFC40288.1 - 0.26 11.1 1.6 23 4.8 0.0 3.8 4 0 0 4 4 3 0 Helix-turn-helix domain COQ7 PF03232.13 EFC40288.1 - 1.2 8.9 4.0 1.2 8.9 0.1 2.9 3 0 0 3 3 3 0 Ubiquinone biosynthesis protein COQ7 DUF3452 PF11934.8 EFC40288.1 - 4.2 6.9 16.4 0.65 9.5 0.2 4.9 3 2 2 5 5 5 0 Domain of unknown function (DUF3452) CARD PF00619.21 EFC40288.1 - 6.7 6.8 18.5 6.8 6.8 0.1 6.9 7 0 0 7 7 7 0 Caspase recruitment domain Cofac_haem_bdg PF04187.13 EFC40288.1 - 8.2 6.3 7.6 2.5 8.0 0.1 3.4 3 1 0 3 3 3 0 Haem-binding uptake, Tiki superfamily, ChaN DUF4464 PF14713.6 EFC40288.1 - 8.9 5.8 35.2 1.7 8.2 0.4 7.1 2 2 4 8 8 8 0 Domain of unknown function (DUF4464) Guanylin PF02058.15 EFC40288.1 - 9 6.9 6.0 5.4 7.6 0.1 3.3 3 0 0 3 3 2 0 Guanylin precursor Ras PF00071.22 EFC40289.1 - 1.2e-31 109.6 0.1 1.9e-31 108.8 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40289.1 - 5.6e-14 52.4 0.0 1e-13 51.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40289.1 - 2.6e-11 43.3 0.0 4.6e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC40289.1 - 2e-10 40.5 0.1 3.9e-10 39.6 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC40289.1 - 6.1e-06 26.2 0.2 0.0024 17.8 0.2 2.5 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC40289.1 - 5.6e-05 23.2 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFC40289.1 - 0.0026 18.2 0.0 0.0048 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 EFC40289.1 - 0.003 17.4 0.6 0.01 15.6 0.1 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 EFC40289.1 - 0.0044 16.2 0.2 1.4 8.0 0.0 2.8 3 0 0 3 3 3 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC40289.1 - 0.0065 15.8 0.3 0.013 14.8 0.3 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EFC40289.1 - 0.043 14.1 0.0 0.099 12.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain MRP-S35 PF10246.9 EFC40289.1 - 0.11 12.4 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 RGS PF00615.19 EFC40290.1 - 9.9e-05 22.6 2.2 0.00018 21.8 2.2 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain PMT2_N PF17987.1 EFC40290.1 - 0.011 16.0 0.8 2.1 8.5 0.1 2.3 2 0 0 2 2 2 0 Phosphoethanolamine N-methyltransferase 2 N-terminal DUF2153 PF09921.9 EFC40290.1 - 0.16 11.8 2.2 0.86 9.4 0.6 2.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2153) AsnC_trans_reg2 PF17805.1 EFC40291.1 - 0.1 12.7 0.0 0.31 11.2 0.0 1.8 2 0 0 2 2 2 0 AsnC-like ligand binding domain tify PF06200.14 EFC40292.1 - 0.14 11.5 0.0 0.37 10.1 0.0 1.6 1 0 0 1 1 1 0 tify domain Otopetrin PF03189.13 EFC40293.1 - 0.11 11.3 5.6 1.5 7.6 0.0 2.7 1 1 1 2 2 2 0 Otopetrin Coilin_N PF15862.5 EFC40294.1 - 0.79 9.5 6.3 38 4.1 4.7 3.0 2 0 0 2 2 2 0 Coilin N-terminus PH PF00169.29 EFC40296.1 - 4.7e-13 49.6 0.5 1.7e-12 47.8 0.5 2.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFC40296.1 - 0.00069 20.0 1.3 0.0011 19.3 0.5 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 EFC40296.1 - 0.015 15.5 1.1 0.082 13.2 1.1 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain AAA PF00004.29 EFC40297.1 - 6.2e-30 104.3 0.1 1.4e-29 103.2 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC40297.1 - 1.2e-09 37.8 0.0 2.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EFC40297.1 - 2.6e-07 30.5 0.1 1.2e-06 28.4 0.0 2.1 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain N_BRCA1_IG PF16158.5 EFC40298.1 - 1e-25 90.4 0.2 2.2e-25 89.4 0.2 1.5 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene WD40 PF00400.32 EFC40300.1 - 2.9e-43 145.0 18.2 1.2e-09 38.6 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC40300.1 - 2.7e-17 62.8 0.1 0.001 19.3 0.1 6.3 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC40300.1 - 2.8e-06 26.5 0.5 3.8 6.4 0.0 4.2 3 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC40300.1 - 3.5e-05 23.3 0.2 0.01 15.2 0.2 3.1 2 1 1 3 3 3 2 WD40-like domain eIF2A PF08662.11 EFC40300.1 - 0.0034 17.3 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF1126 PF06565.12 EFC40301.1 - 9.4e-101 330.8 8.2 1e-35 121.7 0.3 3.3 3 0 0 3 3 3 3 DUF1126 PH-like domain EF-hand_8 PF13833.6 EFC40301.1 - 1.7e-07 31.0 1.3 0.00048 19.9 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 EFC40301.1 - 9.8e-07 29.1 0.4 0.032 14.7 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC40301.1 - 0.0023 17.4 0.2 0.46 10.2 0.0 3.0 3 0 0 3 3 3 1 EF hand NLPC_P60 PF00877.19 EFC40301.1 - 0.083 12.9 0.0 3 7.9 0.0 2.7 2 0 0 2 2 2 0 NlpC/P60 family RolB_RolC PF02027.17 EFC40301.1 - 0.095 12.4 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 RolB/RolC glucosidase family JIP_LZII PF16471.5 EFC40301.1 - 0.13 12.5 0.4 0.31 11.2 0.4 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II SPRY PF00622.28 EFC40302.1 - 0.028 14.5 0.4 0.069 13.3 0.1 1.9 2 0 0 2 2 2 0 SPRY domain Cas_Csn2 PF09711.10 EFC40302.1 - 0.043 13.5 1.3 0.093 12.4 1.3 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csn2) DUF241 PF03087.14 EFC40302.1 - 0.047 13.5 1.1 0.082 12.7 1.1 1.4 1 0 0 1 1 1 0 Arabidopsis protein of unknown function F-box-like PF12937.7 EFC40302.1 - 0.058 13.3 1.1 0.12 12.3 1.1 1.5 1 0 0 1 1 1 0 F-box-like Abhydrolase_1 PF00561.20 EFC40303.1 - 0.00015 21.6 0.0 0.00023 20.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC40303.1 - 0.099 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Phage_holin_3_6 PF07332.11 EFC40303.1 - 5.6 7.0 6.5 1.2 9.2 1.6 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Actin PF00022.19 EFC40304.1 - 4e-130 434.1 0.0 2.7e-76 256.8 0.0 2.7 1 1 1 2 2 2 2 Actin PI3_PI4_kinase PF00454.27 EFC40306.1 - 5.1e-30 105.1 0.3 5.5e-27 95.2 0.3 2.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC40306.1 - 2.4e-05 23.8 0.9 5.4e-05 22.7 0.3 1.8 1 1 1 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) NAD_binding_10 PF13460.6 EFC40307.1 - 1.9e-27 96.4 0.0 2.3e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFC40307.1 - 4.1e-05 23.1 0.0 8e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 EFC40307.1 - 0.0038 16.7 0.0 0.009 15.5 0.0 1.6 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 EFC40307.1 - 0.0058 16.9 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain NmrA PF05368.13 EFC40307.1 - 0.018 14.6 0.0 0.1 12.2 0.0 2.0 2 0 0 2 2 2 0 NmrA-like family RPN7 PF10602.9 EFC40308.1 - 6.2e-47 159.5 2.3 6.2e-47 159.5 2.3 2.1 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 EFC40308.1 - 5.2e-16 59.1 4.2 1.1e-15 58.0 1.4 2.5 2 0 0 2 2 2 1 PCI domain DUF2616 PF11077.8 EFC40308.1 - 0.034 13.9 0.2 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2616) TPR_2 PF07719.17 EFC40308.1 - 0.21 11.8 0.7 1.1 9.6 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NUDIX PF00293.28 EFC40309.1 - 4.5e-08 33.2 0.0 7.1e-08 32.6 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain WD40 PF00400.32 EFC40310.1 - 2.1e-38 129.6 20.3 1.5e-09 38.3 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC40310.1 - 3.1e-17 62.7 0.3 0.0042 17.3 0.0 6.1 2 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC40310.1 - 0.00059 19.3 1.8 0.071 12.4 1.0 2.9 2 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 EFC40310.1 - 0.0017 17.4 1.6 2.1 7.2 0.0 4.0 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFC40310.1 - 0.036 12.7 0.2 4.5 5.8 0.0 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 BBS2_C PF14782.6 EFC40311.1 - 0.0069 15.2 0.3 0.0069 15.2 0.3 1.4 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal Arfaptin PF06456.13 EFC40311.1 - 0.047 13.2 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 Arfaptin-like domain ANAPC4_WD40 PF12894.7 EFC40312.1 - 0.00016 21.9 6.5 1.9 8.8 0.0 5.9 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFC40312.1 - 0.00026 20.6 1.7 0.64 9.6 0.2 3.5 3 1 0 3 3 3 2 PQQ-like domain WD40_like PF17005.5 EFC40312.1 - 0.011 15.1 0.7 0.34 10.2 0.0 3.1 2 1 1 3 3 3 0 WD40-like domain WD40 PF00400.32 EFC40312.1 - 0.13 13.2 14.6 4.6 8.3 0.2 6.7 7 0 0 7 7 7 0 WD domain, G-beta repeat Trehalose_PPase PF02358.16 EFC40313.1 - 0.073 12.2 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 Trehalose-phosphatase Ras PF00071.22 EFC40315.1 - 5.6e-17 61.8 1.8 8.8e-17 61.2 1.8 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40315.1 - 5.2e-05 23.4 0.4 0.00012 22.3 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC40315.1 - 7.3e-05 22.4 0.7 9.5e-05 22.0 0.7 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC40315.1 - 0.0075 15.6 5.2 0.029 13.7 5.2 2.0 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FadR_C PF07840.12 EFC40315.1 - 0.008 16.1 0.9 0.062 13.2 0.0 2.3 2 1 0 2 2 2 1 FadR C-terminal domain RsgA_GTPase PF03193.16 EFC40315.1 - 0.01 15.7 0.7 0.059 13.3 0.7 2.1 2 0 0 2 2 2 0 RsgA GTPase DED PF01335.21 EFC40315.1 - 0.11 12.8 1.0 0.9 9.9 0.1 2.7 3 0 0 3 3 3 0 Death effector domain Poxvirus_B22R_C PF13168.6 EFC40315.1 - 0.15 11.6 0.9 0.9 9.0 0.1 2.0 1 1 0 2 2 2 0 Poxvirus B22R protein C-terminal DUF1366 PF07104.11 EFC40316.1 - 0.041 13.6 0.4 0.097 12.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) GTP_EFTU PF00009.27 EFC40317.1 - 1e-54 185.1 0.5 1e-54 185.1 0.5 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFC40317.1 - 4.7e-19 68.2 0.0 1.6e-18 66.5 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFC40317.1 - 1.4e-09 38.2 0.0 4.4e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFC40317.1 - 4.9e-08 33.0 0.0 1.7e-07 31.2 0.0 2.0 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 EFC40317.1 - 3.9e-06 26.6 0.0 5.8e-05 22.9 0.0 2.6 2 0 0 2 2 2 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 EFC40317.1 - 0.00032 20.8 0.1 0.0019 18.3 0.1 2.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC40317.1 - 0.36 10.7 2.4 0.64 9.9 0.4 2.5 2 0 0 2 2 2 0 RsgA GTPase CENP-B_dimeris PF09026.10 EFC40317.1 - 1.6 9.1 5.4 23 5.4 0.0 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AAA PF00004.29 EFC40318.1 - 2.6e-96 319.1 0.1 1.1e-46 158.5 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC40318.1 - 3.1e-28 97.3 5.6 2.5e-13 49.6 0.9 3.1 2 1 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 EFC40318.1 - 4e-22 78.2 1.0 1.5e-21 76.3 1.0 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 EFC40318.1 - 2.3e-15 56.7 0.0 1e-06 28.6 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFC40318.1 - 6.2e-12 46.2 0.0 0.0024 18.3 0.0 4.4 2 2 1 3 3 3 2 AAA ATPase domain CDC48_2 PF02933.17 EFC40318.1 - 6.9e-12 45.0 0.0 2.8e-11 43.0 0.0 2.0 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.14 EFC40318.1 - 7e-12 45.8 0.0 3.2e-06 27.4 0.0 3.0 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EFC40318.1 - 2.6e-11 43.9 0.0 1.8e-05 24.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFC40318.1 - 9.3e-10 38.6 0.1 0.00035 20.6 0.0 3.4 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC40318.1 - 4.4e-09 36.7 0.6 0.053 13.8 0.0 4.5 3 2 0 3 3 3 2 AAA domain TIP49 PF06068.13 EFC40318.1 - 1.1e-08 34.7 2.3 0.00094 18.5 0.0 3.1 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_14 PF13173.6 EFC40318.1 - 2.3e-08 34.1 0.0 0.024 14.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EFC40318.1 - 1.9e-07 30.7 0.2 0.024 14.0 0.1 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFC40318.1 - 3.5e-07 30.8 0.0 0.076 13.6 0.0 3.3 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 EFC40318.1 - 8.2e-07 29.4 0.0 0.0095 16.3 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Viral_helicase1 PF01443.18 EFC40318.1 - 2.3e-06 27.5 0.0 0.01 15.6 0.0 3.4 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 EFC40318.1 - 5.4e-06 26.3 3.4 0.03 14.1 0.0 3.5 4 0 0 4 4 3 2 IstB-like ATP binding protein ATPase PF06745.13 EFC40318.1 - 6e-06 25.8 0.1 1.2 8.4 0.0 3.6 3 0 0 3 3 3 1 KaiC ATPase_2 PF01637.18 EFC40318.1 - 7.1e-06 26.1 0.9 0.28 11.0 0.0 4.2 4 1 0 4 4 3 2 ATPase domain predominantly from Archaea AAA_28 PF13521.6 EFC40318.1 - 8.5e-06 26.1 0.0 0.11 12.7 0.0 3.3 3 0 0 3 3 3 2 AAA domain Bac_DnaA PF00308.18 EFC40318.1 - 1.7e-05 24.7 0.0 0.21 11.4 0.0 2.4 2 0 0 2 2 2 2 Bacterial dnaA protein TsaE PF02367.17 EFC40318.1 - 2.8e-05 24.1 0.0 0.054 13.5 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Parvo_NS1 PF01057.17 EFC40318.1 - 3.6e-05 23.0 0.1 0.042 12.9 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 EFC40318.1 - 5e-05 22.7 0.0 0.43 9.8 0.0 2.8 2 0 0 2 2 2 2 Zeta toxin Vps4_C PF09336.10 EFC40318.1 - 5.1e-05 23.2 0.8 0.0088 16.0 0.1 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 EFC40318.1 - 7e-05 22.4 0.0 0.1 12.1 0.0 2.8 2 1 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 EFC40318.1 - 7.2e-05 22.8 0.1 0.19 11.6 0.0 3.4 3 1 0 3 3 3 1 NACHT domain AAA_25 PF13481.6 EFC40318.1 - 7.7e-05 22.4 2.7 1.9 8.0 0.1 3.9 2 2 1 4 4 4 1 AAA domain Sigma54_activat PF00158.26 EFC40318.1 - 8.4e-05 22.3 0.0 0.77 9.4 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 EFC40318.1 - 0.0001 22.9 4.0 0.048 14.2 0.0 4.1 5 1 0 5 5 3 1 ABC transporter AAA_24 PF13479.6 EFC40318.1 - 0.00016 21.5 3.8 0.29 10.8 0.0 3.9 4 1 0 4 4 3 2 AAA domain DUF815 PF05673.13 EFC40318.1 - 0.0002 20.6 0.0 0.072 12.2 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 EFC40318.1 - 0.00021 20.6 0.0 0.23 10.6 0.0 2.8 3 0 0 3 3 2 1 NB-ARC domain ResIII PF04851.15 EFC40318.1 - 0.00037 20.5 0.0 0.36 10.8 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 EFC40318.1 - 0.0005 20.0 1.7 3.2 7.6 0.0 4.6 3 1 0 4 4 4 1 NTPase AAA_17 PF13207.6 EFC40318.1 - 0.00055 20.4 7.0 0.21 12.0 0.0 3.8 4 0 0 4 4 3 2 AAA domain AAA_3 PF07726.11 EFC40318.1 - 0.00083 19.2 0.1 2.1 8.2 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) UFD1 PF03152.14 EFC40318.1 - 0.0011 18.5 0.0 0.0033 16.9 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 DUF2075 PF09848.9 EFC40318.1 - 0.0011 18.3 0.0 1 8.5 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EFC40318.1 - 0.0018 17.7 0.2 1.8 8.0 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein Sigma54_activ_2 PF14532.6 EFC40318.1 - 0.0029 17.7 0.0 4.2 7.5 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 EFC40318.1 - 0.0038 17.0 2.6 3.2 7.5 0.8 3.7 3 1 0 3 3 3 1 AAA domain Rad17 PF03215.15 EFC40318.1 - 0.0055 16.6 0.0 0.52 10.2 0.0 2.7 2 1 1 3 3 2 1 Rad17 P-loop domain Cytidylate_kin2 PF13189.6 EFC40318.1 - 0.011 15.9 0.0 2.1 8.5 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase-like family Molydop_binding PF01568.21 EFC40318.1 - 0.012 15.7 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain AAA_30 PF13604.6 EFC40318.1 - 0.015 15.0 0.5 17 5.0 0.1 3.3 3 0 0 3 3 3 0 AAA domain Zot PF05707.12 EFC40318.1 - 0.033 13.8 0.0 0.72 9.5 0.0 2.9 2 1 1 3 3 3 0 Zonular occludens toxin (Zot) Cytidylate_kin PF02224.18 EFC40318.1 - 0.036 13.8 0.0 7.4 6.2 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase AAA_19 PF13245.6 EFC40318.1 - 0.094 13.0 4.9 16 5.8 0.0 4.2 4 1 0 5 5 4 0 AAA domain KAP_NTPase PF07693.14 EFC40318.1 - 0.15 11.3 0.7 2.3 7.4 0.0 2.9 2 2 1 3 3 3 0 KAP family P-loop domain SKI PF01202.22 EFC40318.1 - 0.31 11.2 4.4 7.9 6.6 0.0 3.1 4 0 0 4 4 2 0 Shikimate kinase CCDC14 PF15254.6 EFC40318.1 - 0.9 8.1 6.6 0.031 13.0 0.4 1.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 14 Hydin_ADK PF17213.3 EFC40318.1 - 1.5 9.1 3.7 50 4.1 0.0 3.6 4 0 0 4 4 3 0 Hydin Adenylate kinase-like domain Coatomer_WDAD PF04053.14 EFC40319.1 - 0.0011 18.1 4.5 0.019 14.0 0.7 2.5 1 1 0 2 2 2 2 Coatomer WD associated region DUF4116 PF13475.6 EFC40320.1 - 6.5e-33 112.2 13.9 2.3e-12 46.5 0.4 7.3 7 1 0 7 7 7 5 Domain of unknown function (DUF4116) DUF3294 PF07957.11 EFC40320.1 - 0.13 11.9 0.7 1.5 8.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3294) PPR_2 PF13041.6 EFC40322.1 - 8.8e-08 32.2 6.2 0.0049 17.0 0.1 5.0 5 1 1 6 6 6 4 PPR repeat family PPR PF01535.20 EFC40322.1 - 3.9e-06 26.7 1.7 5.9 7.4 0.0 6.6 6 1 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 EFC40322.1 - 9.8e-05 22.4 0.5 0.037 14.1 0.0 4.0 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC40322.1 - 1.8 8.3 8.7 14 5.5 0.0 4.9 6 0 0 6 6 6 0 PPR repeat PI3Ka PF00613.20 EFC40323.1 - 4.1e-50 169.8 0.3 7.3e-50 168.9 0.3 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFC40323.1 - 2.5e-45 155.3 0.0 9.1e-30 104.3 0.0 2.5 2 0 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EFC40323.1 - 1.6e-14 54.0 0.3 8.5e-08 32.2 0.0 2.8 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 EFC40323.1 - 3e-11 43.4 0.0 1.1e-10 41.7 0.0 2.0 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain DUF4135 PF13575.6 EFC40323.1 - 0.023 14.0 0.0 0.042 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) Sp38 PF07354.12 EFC40324.1 - 0.32 10.4 1.5 22 4.4 0.1 2.8 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) CorA PF01544.18 EFC40325.1 - 0.0059 16.0 4.3 0.0072 15.7 4.3 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein YbfN PF13982.6 EFC40325.1 - 0.0099 16.1 0.3 0.025 14.9 0.1 1.7 2 0 0 2 2 2 1 YbfN-like lipoprotein MbeD_MobD PF04899.12 EFC40325.1 - 0.02 15.0 4.5 0.051 13.7 0.4 2.4 1 1 1 2 2 2 0 MbeD/MobD like DUF948 PF06103.11 EFC40325.1 - 0.054 13.8 2.8 0.88 9.9 1.3 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ADK PF00406.22 EFC40325.1 - 0.064 13.3 0.6 0.13 12.3 0.6 1.4 1 1 0 1 1 1 0 Adenylate kinase Spc7 PF08317.11 EFC40325.1 - 0.1 11.4 12.1 0.15 10.9 12.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1216 PF06746.11 EFC40325.1 - 0.21 11.6 4.3 0.58 10.2 3.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1216) APG6_N PF17675.1 EFC40325.1 - 0.23 12.0 14.4 0.38 11.3 13.2 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 EFC40325.1 - 0.29 10.9 7.0 0.36 10.6 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) GrpE PF01025.19 EFC40325.1 - 0.31 10.7 6.9 0.36 10.5 6.9 1.3 1 0 0 1 1 1 0 GrpE FapA PF03961.13 EFC40325.1 - 0.45 9.1 7.8 0.48 9.0 7.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1664 PF07889.12 EFC40325.1 - 0.51 10.4 4.7 0.55 10.3 3.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 EFC40325.1 - 0.63 10.3 13.8 0.96 9.7 13.8 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Seryl_tRNA_N PF02403.22 EFC40325.1 - 0.85 9.9 11.8 19 5.5 0.8 2.0 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain TMPIT PF07851.13 EFC40325.1 - 1 8.5 5.6 1.2 8.3 5.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein HAUS6_N PF14661.6 EFC40325.1 - 1.3 8.5 9.2 20 4.6 5.3 1.9 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus LMBR1 PF04791.16 EFC40325.1 - 1.4 7.7 3.4 1.5 7.6 3.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PPR PF01535.20 EFC40326.1 - 1.1e-20 72.4 7.8 0.024 14.9 0.1 10.4 11 0 0 11 11 11 5 PPR repeat PPR_2 PF13041.6 EFC40326.1 - 3.6e-12 46.3 5.7 0.26 11.5 0.5 8.9 8 2 1 9 9 9 5 PPR repeat family PPR_1 PF12854.7 EFC40326.1 - 3.1e-09 36.4 0.9 0.0048 16.6 0.0 6.7 9 0 0 9 9 9 2 PPR repeat TPR_19 PF14559.6 EFC40326.1 - 2e-07 31.4 0.0 5 7.7 0.0 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat PPR_3 PF13812.6 EFC40326.1 - 0.00039 20.5 5.4 1.2 9.3 0.0 5.9 6 1 1 7 7 7 1 Pentatricopeptide repeat domain ANAPC3 PF12895.7 EFC40326.1 - 0.00095 19.4 1.6 4 7.7 0.0 4.9 5 1 0 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 Filament PF00038.21 EFC40327.1 - 0.0027 17.3 6.8 0.0027 17.3 6.8 1.6 2 0 0 2 2 2 1 Intermediate filament protein LemA PF04011.12 EFC40327.1 - 0.059 13.2 2.0 0.17 11.7 1.8 2.0 1 1 0 1 1 1 0 LemA family ARD PF03079.14 EFC40327.1 - 0.33 11.1 6.4 0.62 10.2 6.4 1.4 1 0 0 1 1 1 0 ARD/ARD' family DUF4404 PF14357.6 EFC40327.1 - 0.64 10.7 5.9 0.35 11.5 3.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) CLZ PF16526.5 EFC40327.1 - 1.6 9.1 7.9 2.4 8.6 0.8 2.6 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Bac_small_YrzI PF09501.10 EFC40327.1 - 2.4 8.3 13.0 0.9 9.7 1.1 3.1 3 0 0 3 3 3 0 Probable sporulation protein (Bac_small_yrzI) FAM76 PF16046.5 EFC40327.1 - 2.4 7.4 10.8 3 7.1 10.8 1.1 1 0 0 1 1 1 0 FAM76 protein YtxH PF12732.7 EFC40327.1 - 2.7 8.6 5.5 24 5.5 0.1 2.4 1 1 1 2 2 2 0 YtxH-like protein PHM7_cyt PF14703.6 EFC40328.1 - 2.9 8.1 13.9 0.1 12.9 0.6 2.3 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Peptidase_C15 PF01470.17 EFC40329.1 - 2.4e-09 37.6 0.3 2e-06 28.1 0.1 2.2 2 0 0 2 2 2 2 Pyroglutamyl peptidase MMR_HSR1 PF01926.23 EFC40330.1 - 0.0055 16.8 0.1 0.017 15.2 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFC40330.1 - 0.0064 17.0 0.4 0.023 15.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter FtsK_SpoIIIE PF01580.18 EFC40330.1 - 0.046 13.1 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AIG1 PF04548.16 EFC40330.1 - 0.6 9.4 5.7 0.16 11.3 0.1 2.5 2 1 0 2 2 2 0 AIG1 family RhoGEF PF00621.20 EFC40331.1 - 3.2e-36 125.3 5.0 3.2e-36 125.3 5.0 2.5 2 1 0 2 2 2 1 RhoGEF domain Sorb PF02208.16 EFC40331.1 - 0.022 14.6 0.1 0.048 13.5 0.1 1.5 1 0 0 1 1 1 0 Sorbin homologous domain AI-2E_transport PF01594.16 EFC40331.1 - 1.4 8.0 4.0 15 4.7 0.3 2.2 2 0 0 2 2 2 0 AI-2E family transporter Na_Ca_ex PF01699.24 EFC40332.1 - 5.4e-34 117.3 53.6 6e-22 78.2 18.2 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein YMF19 PF02326.15 EFC40332.1 - 0.029 15.1 0.1 0.029 15.1 0.1 4.3 4 0 0 4 4 4 0 Plant ATP synthase F0 Wzy_C PF04932.15 EFC40332.1 - 0.1 12.2 0.0 0.1 12.2 0.0 3.7 3 1 0 4 4 4 0 O-Antigen ligase FAM176 PF14851.6 EFC40332.1 - 0.23 11.1 2.3 0.79 9.4 2.3 2.0 1 1 0 1 1 1 0 FAM176 family OAD_gamma PF04277.13 EFC40332.1 - 1.5 9.5 0.0 1.5 9.5 0.0 3.6 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF4131 PF13567.6 EFC40332.1 - 5.1 6.7 0.0 5.1 6.7 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) Zn_clus PF00172.18 EFC40333.1 - 1.9e-08 34.3 8.9 3.3e-08 33.5 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 EFC40333.1 - 0.014 15.1 1.0 0.014 15.1 1.0 1.8 1 1 0 1 1 1 0 Integrin plexin domain tRNA_synthFbeta PF17759.1 EFC40334.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.4 1 0 0 1 1 1 0 Phenylalanyl tRNA synthetase beta chain CLM domain GSG-1 PF07803.11 EFC40335.1 - 0.32 10.9 3.0 12 5.9 0.1 2.9 2 1 1 3 3 3 0 GSG1-like protein Pox_MCEL PF03291.16 EFC40337.1 - 8.4e-66 222.3 6.8 8.4e-66 222.3 6.8 2.5 1 1 1 2 2 2 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EFC40337.1 - 2e-12 47.6 0.0 6.3e-12 46.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC40337.1 - 9.9e-09 35.7 0.0 2.1e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC40337.1 - 2.6e-08 33.8 0.2 5.1e-08 32.8 0.2 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC40337.1 - 4.1e-07 30.7 0.0 4.1e-07 30.7 0.0 4.6 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFC40337.1 - 0.0038 16.7 3.5 0.29 10.6 0.0 2.9 3 1 0 3 3 3 2 Putative methyltransferase NNMT_PNMT_TEMT PF01234.17 EFC40337.1 - 0.0049 16.1 0.0 0.0081 15.4 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family FtsJ PF01728.19 EFC40337.1 - 0.014 15.5 0.7 0.041 14.0 0.7 1.8 1 1 0 1 1 1 0 FtsJ-like methyltransferase LAP1C PF05609.12 EFC40337.1 - 0.024 13.7 9.6 0.036 13.2 9.6 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 EFC40337.1 - 0.069 11.7 13.8 0.083 11.4 13.8 1.2 1 0 0 1 1 1 0 Macoilin family RWP-RK PF02042.15 EFC40338.1 - 1.9e-06 27.8 0.0 5.1e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 RWP-RK domain JUPITER PF17054.5 EFC40338.1 - 2.9 7.3 8.7 3.7 6.9 8.7 1.1 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter RWP-RK PF02042.15 EFC40340.1 - 7.9e-07 29.0 0.0 1.7e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 RWP-RK domain HTH_Mga PF08280.11 EFC40340.1 - 0.014 15.4 0.8 0.065 13.3 0.3 2.3 2 1 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_23 PF13384.6 EFC40340.1 - 0.13 12.1 0.1 0.29 11.0 0.0 1.6 2 0 0 2 2 2 0 Homeodomain-like domain bZIP_1 PF00170.21 EFC40341.1 - 0.00026 21.0 3.1 0.00026 21.0 3.1 2.1 2 0 0 2 2 2 1 bZIP transcription factor Filament PF00038.21 EFC40341.1 - 0.00093 18.9 0.5 0.0011 18.6 0.5 1.1 1 0 0 1 1 1 1 Intermediate filament protein DivIC PF04977.15 EFC40341.1 - 0.032 14.0 4.6 0.082 12.7 1.8 2.2 2 0 0 2 2 2 0 Septum formation initiator HALZ PF02183.18 EFC40341.1 - 0.036 14.3 2.0 0.62 10.3 0.5 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 EFC40341.1 - 0.051 14.0 7.4 0.093 13.2 2.2 2.2 2 0 0 2 2 2 0 Cell division protein ZapB MbeD_MobD PF04899.12 EFC40341.1 - 0.091 12.9 0.2 0.18 11.9 0.2 1.5 1 0 0 1 1 1 0 MbeD/MobD like bZIP_2 PF07716.15 EFC40341.1 - 0.17 12.0 4.0 0.85 9.8 2.2 2.3 2 0 0 2 2 2 0 Basic region leucine zipper CaKB PF03185.15 EFC40342.1 - 0.088 12.5 1.1 0.29 10.8 0.1 2.3 2 0 0 2 2 2 0 Calcium-activated potassium channel, beta subunit CopD PF05425.13 EFC40342.1 - 1.7 9.1 8.2 0.21 12.0 0.4 2.8 3 0 0 3 3 3 0 Copper resistance protein D DUF2500 PF10694.9 EFC40342.1 - 2.1 8.9 8.8 0.51 10.9 1.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2500) Guanylate_cyc PF00211.20 EFC40344.1 - 6e-28 97.7 0.1 7.1e-28 97.5 0.1 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Hormone_1 PF00103.20 EFC40344.1 - 0.01 15.6 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 0 Somatotropin hormone family Peptidase_U49 PF10463.9 EFC40345.1 - 0.013 15.2 0.9 0.28 10.9 1.2 2.3 2 0 0 2 2 2 0 Peptidase U49 LRR_4 PF12799.7 EFC40345.1 - 1.9 9.0 15.1 58 4.3 0.1 5.5 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) MFS_1 PF07690.16 EFC40347.1 - 1.4e-32 113.0 33.2 3.6e-23 82.1 16.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC40347.1 - 4.8e-11 42.2 14.0 3.5e-10 39.4 13.9 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter Folate_carrier PF01770.18 EFC40347.1 - 0.00024 20.0 11.8 0.0011 17.8 4.7 2.8 2 1 0 2 2 2 2 Reduced folate carrier MFS_3 PF05977.13 EFC40347.1 - 0.0015 17.0 0.1 0.014 13.9 0.0 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector LRR_6 PF13516.6 EFC40348.1 - 4.5e-42 138.5 20.3 0.00028 20.7 0.2 15.3 15 0 0 15 15 15 10 Leucine Rich repeat LRR_8 PF13855.6 EFC40348.1 - 3.7e-26 90.7 15.9 4e-06 26.5 0.4 7.5 2 1 7 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EFC40348.1 - 1.3e-21 76.3 34.6 0.0014 18.9 1.0 10.9 3 2 9 13 13 13 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC40348.1 - 4.7e-07 29.5 8.5 0.0082 15.7 0.1 4.6 1 1 3 5 5 5 2 Leucine-rich repeat LRR_1 PF00560.33 EFC40348.1 - 0.00033 20.8 22.6 17 6.4 0.0 11.4 11 3 1 12 12 9 0 Leucine Rich Repeat DUF4347 PF14252.6 EFC40348.1 - 0.007 16.2 0.4 12 5.7 0.1 4.6 3 2 0 3 3 3 1 Domain of unknown function (DUF4347) F-box-like PF12937.7 EFC40348.1 - 0.014 15.2 0.2 0.029 14.3 0.2 1.4 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC40348.1 - 0.017 15.0 1.0 0.037 13.9 1.0 1.6 1 0 0 1 1 1 0 F-box domain SRP1_TIP1 PF00660.17 EFC40348.1 - 0.087 12.9 0.6 5.7 7.1 0.0 3.0 1 1 1 2 2 2 0 Seripauperin and TIP1 family DUF424 PF04242.13 EFC40348.1 - 0.18 12.1 2.7 2 8.8 0.1 3.8 3 2 0 3 3 3 0 Protein of unknown function (DUF424) LRR_5 PF13306.6 EFC40348.1 - 0.59 10.1 17.5 0.25 11.3 3.5 3.9 2 1 2 4 4 4 0 BspA type Leucine rich repeat region (6 copies) Pkinase PF00069.25 EFC40350.1 - 1.8e-24 86.5 2.2 2.9e-24 85.9 2.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40350.1 - 8.6e-13 48.2 0.6 1.3e-12 47.6 0.6 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC40350.1 - 2.6e-05 23.2 0.1 4e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF2291 PF10054.9 EFC40350.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) Pkinase PF00069.25 EFC40351.1 - 3.7e-45 154.4 0.4 1.2e-44 152.7 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40351.1 - 9.2e-28 97.2 0.0 1.8e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC40351.1 - 3.2e-05 22.9 0.1 3.2e-05 22.9 0.1 2.1 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFC40351.1 - 0.078 12.9 0.0 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF3211 PF11485.8 EFC40351.1 - 0.13 12.5 3.7 0.12 12.6 1.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3211) Hydrolase_3 PF08282.12 EFC40352.1 - 0.62 9.8 4.4 0.48 10.1 0.8 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 EFC40353.1 - 3.1e-17 62.6 28.9 3.1e-17 62.6 28.9 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily PEPCK_N PF17297.2 EFC40353.1 - 0.95 9.0 3.3 22 4.6 0.1 2.2 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase N-terminal domain AMP-binding PF00501.28 EFC40354.1 - 6.6e-42 143.6 0.0 9.8e-42 143.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC40354.1 - 0.0011 19.9 0.3 0.002 19.1 0.3 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain A_thal_3526 PF09713.10 EFC40354.1 - 0.12 12.6 0.2 0.12 12.6 0.2 3.3 5 0 0 5 5 5 0 Plant protein 1589 of unknown function (A_thal_3526) zf-RING_4 PF14570.6 EFC40354.1 - 0.29 10.9 1.3 0.82 9.5 1.3 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain ACAS_N PF16177.5 EFC40354.1 - 2.1 8.3 6.1 0.5 10.3 1.4 2.4 2 1 0 2 2 2 0 Acetyl-coenzyme A synthetase N-terminus Oxidored_FMN PF00724.20 EFC40355.1 - 1.6e-96 323.5 0.0 1.9e-96 323.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family NMO PF03060.15 EFC40355.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Nitronate monooxygenase Oxidored_FMN PF00724.20 EFC40356.1 - 9.8e-90 301.3 0.0 1.1e-89 301.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF4021 PF13213.6 EFC40356.1 - 0.012 15.6 0.4 0.026 14.5 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) Methyltransf_31 PF13847.6 EFC40357.1 - 3.2e-23 82.2 0.0 5.8e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC40357.1 - 1.6e-12 47.9 0.1 2.8e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC40357.1 - 6.8e-12 45.9 0.1 1.2e-11 45.1 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC40357.1 - 2.3e-07 31.5 0.1 4.3e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC40357.1 - 5.2e-07 29.7 0.0 8.7e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC40357.1 - 2.2e-05 23.9 0.2 3.9e-05 23.1 0.2 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 EFC40357.1 - 0.00031 20.2 0.1 0.00052 19.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 EFC40357.1 - 0.00062 19.6 0.0 0.00099 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 EFC40357.1 - 0.012 14.6 0.0 0.018 14.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_32 PF13679.6 EFC40357.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EFC40357.1 - 0.019 14.5 0.1 0.038 13.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain TehB PF03848.14 EFC40357.1 - 0.081 12.3 0.1 0.18 11.2 0.1 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB CMAS PF02353.20 EFC40357.1 - 0.19 11.0 0.1 0.3 10.3 0.1 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Metallophos PF00149.28 EFC40358.1 - 1.2e-06 29.1 0.7 2.7e-06 28.0 0.7 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase YqzM PF14141.6 EFC40358.1 - 1.3 9.1 5.9 2.8 8.1 5.9 1.5 1 0 0 1 1 1 0 YqzM-like protein Ribonuclease_T2 PF00445.18 EFC40359.1 - 1e-23 84.5 0.0 1.3e-23 84.2 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Glyco_hydro_92 PF07971.12 EFC40361.1 - 1.5e-77 261.5 0.1 2.2e-77 261.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 EFC40361.1 - 3.2e-23 82.9 7.1 1.1e-11 45.2 0.5 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 92 N-terminal domain NAD_binding_1 PF00175.21 EFC40362.1 - 4.9e-08 33.6 0.0 1.2e-07 32.4 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Putative_PNPOx PF01243.20 EFC40362.1 - 1.4e-05 25.1 0.0 0.014 15.6 0.0 2.5 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase NAD_binding_6 PF08030.12 EFC40362.1 - 0.0066 16.6 0.1 1.3 9.1 0.1 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Fz PF01392.22 EFC40363.1 - 4.9e-09 36.8 6.9 7.8e-09 36.1 6.9 1.3 1 0 0 1 1 1 1 Fz domain C2 PF00168.30 EFC40364.1 - 2e-10 40.9 0.0 5.7e-10 39.4 0.0 1.8 1 0 0 1 1 1 1 C2 domain DUF2894 PF11445.8 EFC40364.1 - 0.0011 19.4 3.0 0.0011 19.4 3.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF2894) Hydrolase_4 PF12146.8 EFC40365.1 - 0.1 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ras PF00071.22 EFC40367.1 - 2.8e-62 209.1 0.1 3.4e-62 208.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40367.1 - 1.4e-33 115.6 0.2 3.1e-33 114.6 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40367.1 - 5.6e-13 48.7 0.0 7.6e-13 48.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC40367.1 - 3.2e-05 24.0 0.2 8e-05 22.7 0.0 1.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC40367.1 - 0.00019 21.4 0.0 0.4 10.6 0.0 2.4 2 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC40367.1 - 0.00025 20.6 0.1 0.0016 18.0 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC40367.1 - 0.0067 15.8 0.0 0.0086 15.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EFC40367.1 - 0.075 13.3 0.1 0.22 11.8 0.1 1.8 1 1 1 2 2 2 0 AAA domain DAP3 PF10236.9 EFC40367.1 - 0.079 12.1 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.6 EFC40367.1 - 0.1 12.3 0.2 0.37 10.5 0.0 1.8 1 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 EFC40368.1 - 3.5e-19 69.2 0.2 7e-19 68.2 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40368.1 - 4.5e-05 22.9 0.1 0.00013 21.4 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase MSL2-CXC PF16682.5 EFC40368.1 - 0.0016 18.5 22.4 0.003 17.7 22.4 1.4 1 0 0 1 1 1 1 CXC domain of E3 ubiquitin-protein ligase MSL2 Kdo PF06293.14 EFC40368.1 - 0.067 12.5 0.3 0.14 11.5 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC40368.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family TPR_2 PF07719.17 EFC40369.1 - 1.2e-15 56.2 13.8 0.0014 18.6 0.3 7.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40369.1 - 3.7e-15 55.0 17.2 0.00034 20.3 0.8 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40369.1 - 3.5e-09 36.8 10.4 0.028 14.7 0.2 5.0 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40369.1 - 1.2e-08 34.5 18.8 0.01 16.0 0.8 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC40369.1 - 5.3e-06 26.7 10.6 2.3 9.0 0.0 6.7 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC40369.1 - 7.5e-05 23.3 0.1 5.9 7.6 0.0 4.1 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40369.1 - 0.00015 21.5 9.8 0.0045 16.9 0.1 5.2 4 1 0 4 4 4 1 Tetratricopeptide repeat HTH_Bact PF18768.1 EFC40369.1 - 0.00052 19.5 4.5 0.022 14.3 0.4 3.5 3 0 0 3 3 3 1 Helix-turn-helix bacterial domain ANAPC3 PF12895.7 EFC40369.1 - 0.0008 19.6 12.4 1.4 9.2 0.3 4.2 2 2 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFC40369.1 - 0.0012 18.7 1.2 0.55 10.2 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC40369.1 - 0.0025 17.9 0.0 0.92 9.7 0.0 4.0 3 2 2 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 EFC40369.1 - 0.0089 16.1 12.3 0.089 12.9 0.7 3.9 2 1 0 3 3 3 2 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 EFC40369.1 - 0.013 15.2 2.3 15 5.3 0.1 3.4 3 1 0 3 3 3 0 26S proteasome subunit RPN7 TPR_14 PF13428.6 EFC40369.1 - 0.018 15.8 1.0 17 6.6 0.0 4.8 5 1 0 6 6 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40369.1 - 0.019 15.5 1.5 13 6.4 0.1 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC40369.1 - 0.07 13.1 1.2 0.07 13.1 1.2 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC40369.1 - 0.097 12.0 0.0 11 5.3 0.0 2.1 1 1 1 2 2 2 0 MalT-like TPR region DUF2225 PF09986.9 EFC40369.1 - 0.2 11.4 6.9 0.18 11.5 2.1 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 EFC40369.1 - 0.98 9.2 12.4 0.25 11.1 2.1 4.0 4 0 0 4 4 4 0 TPR repeat ABC_membrane PF00664.23 EFC40370.1 - 2.4e-46 158.6 13.7 3.3e-46 158.2 13.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC40370.1 - 1.2e-06 29.0 0.0 2.6e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane_2 PF06472.15 EFC40370.1 - 0.022 14.2 1.5 0.033 13.6 1.5 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 Phage_Mu_Gam PF07352.12 EFC40370.1 - 0.075 12.9 0.2 0.19 11.6 0.2 1.6 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein SMC_N PF02463.19 EFC40370.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Tubulin PF00091.25 EFC40371.1 - 4.8e-30 105.2 0.1 4.1e-29 102.2 0.1 2.2 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC40371.1 - 1.2e-10 41.7 0.0 3.2e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 Tubulin C-terminal domain RPW8 PF05659.11 EFC40371.1 - 0.021 14.5 0.4 0.093 12.4 0.1 2.1 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Misat_Tub_SegII PF10644.9 EFC40371.1 - 0.03 14.6 0.2 0.074 13.4 0.2 1.7 1 1 0 1 1 1 0 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 EFC40371.1 - 0.063 12.5 0.0 0.22 10.7 0.0 1.8 2 0 0 2 2 2 0 Tubulin like SPRY PF00622.28 EFC40372.1 - 2.3e-06 27.7 0.1 0.00033 20.7 0.0 3.4 2 1 0 2 2 2 1 SPRY domain F-box-like PF12937.7 EFC40372.1 - 4.9e-05 23.1 0.0 0.00015 21.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like Oxidored_FMN PF00724.20 EFC40373.1 - 1.2e-78 264.8 0.0 1.5e-78 264.5 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family PRiA4_ORF3 PF07929.11 EFC40374.1 - 9.3e-11 41.7 0.2 1.6e-10 41.0 0.2 1.4 1 0 0 1 1 1 1 Plasmid pRiA4b ORF-3-like protein Colicin_immun PF09204.10 EFC40374.1 - 0.0057 17.1 0.5 0.023 15.2 0.1 2.3 2 0 0 2 2 2 1 Bacterial self-protective colicin-like immunity LRR_6 PF13516.6 EFC40375.1 - 3.5e-46 151.3 13.6 6.9e-05 22.6 0.0 15.4 15 0 0 15 15 15 13 Leucine Rich repeat LRR_8 PF13855.6 EFC40375.1 - 1.4e-33 114.4 10.3 1.9e-06 27.5 0.4 7.3 4 2 4 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC40375.1 - 2.6e-27 94.4 23.0 9.9e-05 22.6 0.5 9.6 5 2 5 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40375.1 - 2.5e-09 36.4 12.5 23 6.0 0.0 11.5 11 3 2 13 13 13 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC40375.1 - 7.2e-08 32.1 3.9 0.00059 19.4 0.3 4.1 1 1 3 4 4 4 2 Leucine-rich repeat DUF4347 PF14252.6 EFC40375.1 - 0.00013 21.9 1.5 3.8 7.3 0.1 5.1 2 2 0 3 3 3 2 Domain of unknown function (DUF4347) LRR_5 PF13306.6 EFC40375.1 - 0.18 11.8 14.5 0.62 10.0 0.9 3.8 2 1 1 3 3 3 0 BspA type Leucine rich repeat region (6 copies) BTG PF07742.12 EFC40376.1 - 3.4e-27 94.6 0.0 4.4e-27 94.2 0.0 1.2 1 0 0 1 1 1 1 BTG family Radical_SAM PF04055.21 EFC40379.1 - 1.5e-09 38.5 0.2 3e-09 37.5 0.2 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 EFC40379.1 - 6.8e-05 23.0 1.3 0.00036 20.6 1.3 2.2 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 EFC40379.1 - 0.0021 18.4 2.8 0.0065 16.7 0.2 2.9 3 0 0 3 3 3 1 4Fe-4S single cluster domain SOBP PF15279.6 EFC40380.1 - 0.86 10.2 17.8 1.1 9.8 17.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein PARP PF00644.20 EFC40381.1 - 9.8e-62 208.0 0.1 9.8e-62 208.0 0.1 2.0 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFC40381.1 - 1.7e-43 147.9 1.2 4.4e-43 146.7 1.2 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFC40381.1 - 4.5e-25 87.5 3.2 3.1e-24 84.8 3.5 2.3 2 0 0 2 2 2 1 WGR domain BRCT PF00533.26 EFC40381.1 - 2.1e-10 40.8 0.2 6.2e-10 39.3 0.2 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC40381.1 - 1.8e-09 37.9 0.1 7.1e-09 36.0 0.1 2.1 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Radial_spoke PF04712.12 EFC40381.1 - 0.0007 18.7 12.6 0.051 12.5 1.3 2.3 2 0 0 2 2 2 2 Radial spokehead-like protein PTCB-BRCT PF12738.7 EFC40381.1 - 0.00092 19.1 0.1 0.0025 17.7 0.1 1.8 1 0 0 1 1 1 1 twin BRCT domain PI3K_1B_p101 PF10486.9 EFC40381.1 - 0.033 12.0 13.8 0.012 13.4 2.1 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit YL1 PF05764.13 EFC40381.1 - 0.78 9.8 29.4 2.1 8.4 10.7 2.2 2 0 0 2 2 2 0 YL1 nuclear protein FAM176 PF14851.6 EFC40381.1 - 2.4 7.8 19.1 2.3 7.9 6.7 2.7 3 0 0 3 3 3 0 FAM176 family DUF1840 PF08895.11 EFC40381.1 - 5.3 7.4 11.6 6.7 7.1 0.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) PBP1_TM PF14812.6 EFC40381.1 - 5.7 7.4 21.6 6 7.3 5.2 3.1 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RE_R_Pab1 PF09522.10 EFC40382.1 - 0.0051 16.9 2.3 0.048 13.8 0.2 2.7 2 0 0 2 2 2 1 R.Pab1 restriction endonuclease HI0933_like PF03486.14 EFC40382.1 - 0.069 11.8 0.0 0.17 10.6 0.0 1.5 1 1 0 1 1 1 0 HI0933-like protein DUF3899 PF13038.6 EFC40383.1 - 0.022 15.3 1.0 0.059 13.9 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Amino_oxidase PF01593.24 EFC40384.1 - 1.4e-45 156.4 0.0 1.9e-45 156.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC40384.1 - 9.5e-13 48.2 0.0 3.7e-12 46.3 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFC40384.1 - 1.2e-08 34.6 2.1 0.00056 19.2 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFC40384.1 - 1.8e-06 27.4 0.1 7.7e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC40384.1 - 6.8e-06 25.9 0.0 0.00053 19.7 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EFC40384.1 - 9.9e-06 24.9 0.2 0.00039 19.6 0.1 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFC40384.1 - 3.6e-05 23.3 1.7 0.0012 18.3 0.2 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFC40384.1 - 5.1e-05 22.2 0.3 0.003 16.3 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EFC40384.1 - 0.00012 21.3 0.0 0.00058 19.1 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EFC40384.1 - 0.00054 19.3 0.3 0.0011 18.3 0.3 1.5 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 EFC40384.1 - 0.0038 16.3 0.2 0.035 13.2 0.3 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 EFC40384.1 - 0.0051 16.1 0.1 0.029 13.6 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 EFC40384.1 - 0.031 14.3 0.2 0.06 13.4 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDI PF00996.18 EFC40384.1 - 0.055 12.0 0.2 0.14 10.6 0.0 1.7 2 0 0 2 2 2 0 GDP dissociation inhibitor NAD_binding_9 PF13454.6 EFC40384.1 - 0.066 13.2 0.1 16 5.5 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 EFC40384.1 - 0.071 12.4 0.1 0.13 11.5 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 EFC40384.1 - 0.13 12.9 0.9 1.4 9.5 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Beta_helix PF13229.6 EFC40385.1 - 3.2e-05 23.8 43.9 0.00015 21.7 14.2 3.6 3 1 0 4 4 4 2 Right handed beta helix region DUF4116 PF13475.6 EFC40386.1 - 2.3e-16 59.3 7.1 7e-06 25.7 0.0 4.2 3 1 1 4 4 4 3 Domain of unknown function (DUF4116) F-box PF00646.33 EFC40386.1 - 0.0066 16.3 0.9 0.012 15.4 0.1 2.0 2 0 0 2 2 2 1 F-box domain DUF3023 PF11224.8 EFC40386.1 - 0.015 15.2 2.2 2.8 7.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3023) NurA PF09376.10 EFC40386.1 - 0.096 12.4 0.9 0.2 11.3 0.9 1.5 1 0 0 1 1 1 0 NurA domain AAA_9 PF12781.7 EFC40386.1 - 0.11 11.6 1.4 0.19 10.8 0.4 1.8 2 0 0 2 2 2 0 ATP-binding dynein motor region Pox_D5 PF03288.16 EFC40387.1 - 0.027 15.0 0.6 0.13 12.8 0.4 2.1 2 0 0 2 2 2 0 Poxvirus D5 protein-like NapE PF06796.11 EFC40387.1 - 0.14 11.7 0.1 11 5.6 0.0 2.5 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE NHL PF01436.21 EFC40387.1 - 0.5 10.5 4.0 4.5 7.5 0.2 3.2 3 0 0 3 3 3 0 NHL repeat Kelch_3 PF13415.6 EFC40388.1 - 6.4e-27 93.3 3.5 1.6e-07 31.4 0.0 5.7 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC40388.1 - 1.7e-24 85.2 12.1 3.5e-05 23.9 0.2 5.9 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFC40388.1 - 8.1e-24 83.4 16.9 6.8e-05 22.8 0.5 6.2 5 1 1 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC40388.1 - 8e-18 63.8 11.1 0.0011 18.5 0.1 5.7 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EFC40388.1 - 1.2e-17 63.5 17.8 0.00014 21.8 0.2 6.2 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFC40388.1 - 6.3e-06 26.0 12.3 0.0059 16.5 0.2 5.2 5 0 0 5 5 5 2 Kelch motif COX2_TM PF02790.15 EFC40388.1 - 0.014 15.5 0.5 0.031 14.4 0.5 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, transmembrane domain GTP_EFTU_D3 PF03143.17 EFC40390.1 - 3e-10 40.4 0.1 5.8e-10 39.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU PF00009.27 EFC40390.1 - 1.2e-05 25.0 0.2 1.5e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFC40390.1 - 3.8e-05 24.0 0.7 0.00015 22.1 0.3 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Ank_2 PF12796.7 EFC40391.1 - 2.7e-29 101.6 0.1 6.2e-10 39.5 0.0 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC40391.1 - 6.4e-21 72.2 0.4 0.00084 19.6 0.0 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EFC40391.1 - 2.8e-19 69.2 1.5 0.0002 21.8 0.0 5.1 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EFC40391.1 - 1.4e-17 63.2 0.2 0.039 14.4 0.0 6.2 5 1 1 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 EFC40391.1 - 2.5e-12 46.8 0.3 0.0034 17.7 0.0 5.2 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Shigella_OspC PF06128.11 EFC40391.1 - 0.03 14.1 0.0 7.6 6.2 0.0 2.2 2 0 0 2 2 2 0 Shigella flexneri OspC protein DUF4281 PF14108.6 EFC40392.1 - 1.3e-29 103.1 7.1 1.8e-29 102.7 7.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4281) Herpes_LMP1 PF05297.11 EFC40392.1 - 0.47 9.6 2.4 0.69 9.0 2.4 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) R3H PF01424.22 EFC40393.1 - 0.00068 19.6 1.3 0.0018 18.2 0.0 2.4 4 0 0 4 4 4 1 R3H domain hSac2 PF12456.8 EFC40394.1 - 8.1e-08 32.0 0.1 2.4e-07 30.5 0.1 1.8 1 0 0 1 1 1 1 Inositol phosphatase Myosin_TH1 PF06017.13 EFC40394.1 - 0.00027 20.7 0.7 0.00087 19.0 0.2 2.2 2 1 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding DUF438 PF04282.13 EFC40394.1 - 0.065 13.2 0.1 0.71 9.9 0.2 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF438) Poty_coat PF00767.18 EFC40394.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Potyvirus coat protein AAA_16 PF13191.6 EFC40395.1 - 0.0079 16.6 0.0 0.022 15.1 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFC40395.1 - 0.02 14.9 0.0 1.9 8.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) RGS PF00615.19 EFC40396.1 - 1.2e-09 38.4 0.2 2.3e-09 37.6 0.2 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF1284 PF06935.11 EFC40396.1 - 0.072 13.5 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1284) DUF3624 PF12292.8 EFC40397.1 - 0.14 12.6 2.7 14 6.2 1.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) UDPGP PF01704.18 EFC40399.1 - 9.2e-172 571.3 2.8 1.1e-171 571.1 2.8 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4121 PF13497.6 EFC40399.1 - 0.083 12.0 0.5 11 5.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4121) Pkinase PF00069.25 EFC40400.1 - 6.9e-47 160.0 0.2 1.1e-46 159.3 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40400.1 - 6.9e-20 71.4 0.1 1.6e-19 70.2 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase BBIP10 PF14777.6 EFC40400.1 - 1.7e-19 69.1 1.8 3.1e-19 68.3 1.8 1.4 1 0 0 1 1 1 1 Cilia BBSome complex subunit 10 Kinase-like PF14531.6 EFC40400.1 - 2.9e-06 26.8 0.0 4.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC40400.1 - 0.001 19.1 0.0 0.0016 18.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC40400.1 - 0.001 18.5 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFC40400.1 - 0.025 13.5 0.0 0.048 12.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 EFC40400.1 - 0.03 13.9 0.1 0.055 13.1 0.1 1.4 1 0 0 1 1 1 0 RIO1 family LRR_6 PF13516.6 EFC40401.1 - 3.8e-57 185.5 20.3 0.00034 20.4 0.0 15.0 15 0 0 15 15 15 13 Leucine Rich repeat LRR_8 PF13855.6 EFC40401.1 - 3e-38 129.4 40.2 4.3e-08 32.8 1.3 6.7 2 1 7 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EFC40401.1 - 2.8e-27 94.3 23.6 0.0012 19.2 0.6 8.5 3 2 4 10 10 10 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40401.1 - 1.3e-13 49.5 4.0 22 6.1 0.0 12.1 14 1 1 15 15 15 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC40401.1 - 3.1e-06 26.8 5.3 0.14 11.6 0.2 4.3 1 1 4 5 5 5 4 Leucine-rich repeat F-box-like PF12937.7 EFC40401.1 - 0.0002 21.2 0.1 0.00036 20.4 0.1 1.4 1 0 0 1 1 1 1 F-box-like PI-TkoII_IV PF18714.1 EFC40401.1 - 0.093 12.2 4.0 0.22 11.0 0.4 2.7 1 1 0 2 2 2 0 DNA polymerase II intein Domain IV Mannitol_dh PF01232.23 EFC40401.1 - 0.48 10.6 4.8 39 4.4 0.1 3.8 1 1 4 6 6 6 0 Mannitol dehydrogenase Rossmann domain ApoB100_C PF12491.8 EFC40401.1 - 0.85 9.6 7.0 39 4.3 0.1 4.8 3 2 1 4 4 4 0 Apolipoprotein B100 C terminal PulA_N1 PF17999.1 EFC40401.1 - 7.6 7.3 6.2 27 5.6 0.1 3.7 2 2 2 4 4 4 0 Pullulanase N1-terminal domain AbiEii PF08843.11 EFC40402.1 - 2.4e-20 73.5 0.0 3.3e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system RSN1_7TM PF02714.15 EFC40403.1 - 2.2e-22 79.7 14.2 2.2e-22 79.7 14.2 1.8 2 1 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate DUF420 PF04238.12 EFC40403.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF420) PHM7_cyt PF14703.6 EFC40404.1 - 1.2e-14 55.0 3.3 1.2e-14 55.0 3.3 1.4 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EFC40404.1 - 6.8e-06 25.9 10.9 2.8e-05 23.9 9.9 2.5 2 1 0 2 2 2 1 Late exocytosis, associated with Golgi transport DUF4834 PF16118.5 EFC40404.1 - 0.65 11.0 0.1 0.65 11.0 0.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) DEP PF00610.21 EFC40405.1 - 3e-07 30.4 0.1 6.2e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF1499 PF07386.11 EFC40405.1 - 2.5e-06 28.0 0.0 1.4e-05 25.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1499) Androgen_recep PF02166.16 EFC40405.1 - 0.0068 15.3 10.0 0.0068 15.3 10.0 2.1 1 1 1 2 2 2 1 Androgen receptor Glyco_hydro_30 PF02055.16 EFC40406.1 - 9.4e-89 297.8 2.1 1.1e-88 297.5 2.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 EFC40406.1 - 1.3e-07 31.8 0.0 2.4e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain DUF898 PF05987.13 EFC40407.1 - 0.032 13.3 0.0 0.04 13.0 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) Ig_C17orf99 PF17736.1 EFC40407.1 - 0.052 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 C17orf99 Ig domain R3H PF01424.22 EFC40408.1 - 4.6e-12 45.7 0.0 1.2e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 EFC40408.1 - 0.01 15.8 18.8 0.01 15.8 18.8 6.2 6 0 0 6 6 6 0 NF-X1 type zinc finger Cadherin_4 PF17803.1 EFC40409.1 - 0.053 14.1 1.4 0.14 12.8 1.4 1.7 1 0 0 1 1 1 0 Bacterial cadherin-like domain Big_9 PF17963.1 EFC40409.1 - 0.21 12.3 4.9 0.31 11.8 2.1 2.4 2 0 0 2 2 2 0 Bacterial Ig domain Zip PF02535.22 EFC40409.1 - 0.28 10.4 6.5 0.35 10.0 6.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter LicD PF04991.13 EFC40409.1 - 0.51 10.4 12.0 0.089 12.9 7.7 1.9 2 0 0 2 2 2 0 LicD family F-protein PF00469.20 EFC40409.1 - 1.4 8.4 6.6 2.5 7.6 6.6 1.3 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef EOS1 PF12326.8 EFC40409.1 - 1.8 8.4 4.2 3.7 7.5 4.2 1.5 1 0 0 1 1 1 0 N-glycosylation protein FGF-BP1 PF06473.12 EFC40409.1 - 2 8.2 13.1 3.2 7.5 10.9 2.1 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) AIF_C PF14721.6 EFC40409.1 - 2.2 8.6 8.3 5.1 7.5 8.3 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Macoilin PF09726.9 EFC40409.1 - 2.4 6.6 15.7 3.2 6.2 15.7 1.1 1 0 0 1 1 1 0 Macoilin family Sec62 PF03839.16 EFC40409.1 - 4.3 6.8 8.7 9 5.7 8.7 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4834 PF16118.5 EFC40409.1 - 6.5 7.8 9.1 2 9.4 5.8 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) Paramyxo_ncap PF00973.19 EFC40409.1 - 8.9 5.1 12.2 14 4.4 12.2 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Spindle_Spc25 PF08234.12 EFC40410.1 - 0.15 12.3 3.8 0.5 10.6 0.3 2.8 2 1 1 3 3 3 0 Chromosome segregation protein Spc25 CCDC32 PF14989.6 EFC40410.1 - 1.7 8.6 10.3 0.067 13.2 1.9 2.6 2 1 0 2 2 2 0 Coiled-coil domain containing 32 Suf PF05843.14 EFC40411.1 - 3.8e-58 197.8 15.6 9.6e-58 196.5 2.4 4.2 4 1 0 4 4 4 1 Suppressor of forked protein (Suf) TPR_16 PF13432.6 EFC40411.1 - 3.8e-07 30.6 0.1 0.00019 22.0 0.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40411.1 - 1.3e-05 25.6 0.2 0.028 15.2 0.1 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat NRDE-2 PF08424.10 EFC40411.1 - 0.00012 21.4 1.5 0.072 12.2 0.0 2.9 3 0 0 3 3 3 2 NRDE-2, necessary for RNA interference DBC1 PF14443.6 EFC40411.1 - 0.001 19.0 0.4 2.3 8.2 0.1 3.5 2 1 0 2 2 2 2 DBC1 TPR_12 PF13424.6 EFC40411.1 - 0.051 13.9 0.4 2.4 8.5 0.2 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40411.1 - 0.066 13.7 0.0 18 5.9 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat COX4 PF02936.14 EFC40411.1 - 0.074 13.1 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV Mad3_BUB1_I PF08311.12 EFC40411.1 - 0.12 12.4 4.2 4.4 7.3 0.1 4.2 3 1 1 4 4 4 0 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 EFC40411.1 - 0.2 11.8 6.4 3.6 7.9 0.7 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40411.1 - 0.22 11.9 1.1 9.5 6.7 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Rhomboid PF01694.22 EFC40413.1 - 1.1e-13 51.5 18.9 1.1e-13 51.5 18.9 2.4 2 1 0 2 2 2 1 Rhomboid family DUF1294 PF06961.13 EFC40413.1 - 0.79 10.0 3.8 3.4 8.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) Comm PF15957.5 EFC40413.1 - 3 8.2 7.6 0.45 10.9 1.0 2.6 3 0 0 3 3 3 0 Commissureless Peptidase_M54 PF07998.11 EFC40414.1 - 1.3e-09 38.3 3.5 4.2e-09 36.7 1.2 2.2 2 0 0 2 2 2 1 Peptidase family M54 Presenilin PF01080.17 EFC40414.1 - 0.13 11.1 3.2 0.38 9.5 3.2 1.7 1 1 0 1 1 1 0 Presenilin RRM_1 PF00076.22 EFC40415.1 - 1.7e-18 66.2 0.3 1.7e-16 59.8 0.3 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC40415.1 - 4.9e-06 26.2 0.0 0.0098 15.5 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC40415.1 - 0.015 15.4 0.1 0.029 14.5 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif Limkain-b1 PF11608.8 EFC40415.1 - 0.045 13.8 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Limkain b1 FHA PF00498.26 EFC40416.1 - 4.4e-11 43.0 0.1 9.6e-11 41.9 0.1 1.6 1 1 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFC40416.1 - 0.00018 21.7 0.0 0.00024 21.4 0.0 1.4 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain MU2_FHA PF18221.1 EFC40416.1 - 0.012 15.6 0.0 0.065 13.3 0.0 1.9 2 0 0 2 2 2 0 Mutator 2 Fork head associated domain CS PF04969.16 EFC40417.1 - 1.8e-16 60.9 6.5 2.7e-16 60.4 6.5 1.3 1 0 0 1 1 1 1 CS domain UPF0669 PF17065.5 EFC40418.1 - 2.7e-23 82.7 21.4 3.4e-06 27.0 0.4 10.7 10 2 2 12 12 12 5 Putative cytokine, C6ORF120 Man-6-P_recep PF02157.15 EFC40418.1 - 4e-11 42.5 0.1 7.7e-11 41.6 0.1 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 EFC40418.1 - 7.4e-07 29.3 0.0 1.8e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein 27 PPC PF04151.15 EFC40418.1 - 0.0044 18.1 0.3 0.0044 18.1 0.3 13.9 14 0 0 14 14 14 6 Bacterial pre-peptidase C-terminal domain DUF4469 PF14734.6 EFC40418.1 - 0.099 12.8 0.4 52 4.1 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4469) with IG-like fold AAA_23 PF13476.6 EFC40419.1 - 0.14 12.7 9.3 0.17 12.4 9.3 1.2 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 EFC40420.1 - 3.5e-38 126.4 17.2 0.00025 20.8 0.2 11.4 12 0 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC40420.1 - 1.7e-29 101.4 8.6 1.5e-08 34.3 0.0 5.3 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC40420.1 - 6e-22 77.4 19.9 6.2e-05 23.3 2.3 7.3 3 3 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40420.1 - 4.7e-11 41.6 0.7 0.22 12.2 0.1 8.2 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC40420.1 - 1e-06 28.3 0.7 0.0039 16.7 0.2 3.3 1 1 3 4 4 4 2 Leucine-rich repeat NIPSNAP PF07978.13 EFC40421.1 - 6.2e-05 23.2 0.0 6.6e-05 23.1 0.0 1.0 1 0 0 1 1 1 1 NIPSNAP DUF1514 PF07438.11 EFC40421.1 - 0.075 12.9 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1514) Exo_endo_phos PF03372.23 EFC40422.1 - 2.2e-13 50.3 0.0 3.2e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ste5 PF11610.8 EFC40423.1 - 0.93 9.4 7.5 1.4 8.8 0.0 3.3 4 0 0 4 4 4 0 Scaffold protein Ste5, Fus3-binding region Translin PF01997.16 EFC40425.1 - 9.4e-44 149.8 1.0 1.2e-43 149.6 1.0 1.1 1 0 0 1 1 1 1 Translin family WASH_WAHD PF11945.8 EFC40425.1 - 0.012 15.1 0.9 0.017 14.7 0.9 1.3 1 0 0 1 1 1 0 WAHD domain of WASH complex AIP3 PF03915.13 EFC40425.1 - 0.023 13.8 4.2 0.038 13.1 0.4 2.5 2 1 1 3 3 3 0 Actin interacting protein 3 Syntaxin_2 PF14523.6 EFC40425.1 - 0.058 13.8 1.3 0.23 11.9 0.5 2.4 2 1 0 2 2 2 0 Syntaxin-like protein Ku_PK_bind PF08785.11 EFC40425.1 - 0.062 13.4 0.8 0.15 12.2 0.4 1.7 1 1 1 2 2 2 0 Ku C terminal domain like DUF1664 PF07889.12 EFC40425.1 - 0.089 12.8 0.3 1.2 9.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ATP-synt_D PF01813.17 EFC40425.1 - 0.12 12.2 0.1 0.92 9.3 0.0 2.3 2 1 0 2 2 2 0 ATP synthase subunit D Jnk-SapK_ap_N PF09744.9 EFC40425.1 - 0.13 12.5 1.3 0.21 11.8 0.8 1.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 RecG_N PF17190.4 EFC40425.1 - 3.1 8.6 6.9 0.41 11.4 0.6 2.6 3 1 0 3 3 3 0 RecG N-terminal helical domain OAM_alpha PF16552.5 EFC40426.1 - 0.0036 17.2 0.3 0.011 15.7 0.1 1.9 2 0 0 2 2 2 1 D-ornithine 4,5-aminomutase alpha-subunit STAT_alpha PF01017.20 EFC40426.1 - 0.0056 16.6 1.3 0.077 12.9 0.2 2.9 2 0 0 2 2 2 1 STAT protein, all-alpha domain Ribosomal_L50 PF10501.9 EFC40426.1 - 0.022 14.9 6.1 0.051 13.7 0.7 3.9 4 0 0 4 4 4 0 Ribosomal subunit 39S RP-C_C PF11800.8 EFC40427.1 - 0.017 15.2 0.0 0.017 15.2 0.0 3.5 3 1 1 4 4 4 0 Replication protein C C-terminal region DUF1515 PF07439.11 EFC40427.1 - 0.041 13.9 11.7 0.16 12.0 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1515) Amino_oxidase PF01593.24 EFC40428.1 - 4.8e-25 88.8 0.0 8.9e-25 87.9 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC40428.1 - 2e-13 50.4 0.0 4.1e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC40428.1 - 3.5e-11 43.3 0.0 2.5e-06 27.3 0.0 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFC40428.1 - 2e-07 30.5 1.1 0.00087 18.5 0.4 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 EFC40428.1 - 3.1e-07 29.9 0.0 6.2e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFC40428.1 - 2.9e-05 23.5 2.4 9.3e-05 21.8 0.4 2.1 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EFC40428.1 - 0.0001 21.7 1.9 0.00057 19.2 0.4 2.2 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 EFC40428.1 - 0.00017 21.1 0.0 0.00053 19.5 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFC40428.1 - 0.00029 19.7 0.3 0.0039 16.0 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 EFC40428.1 - 0.002 17.4 0.2 0.0044 16.3 0.2 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC40428.1 - 0.0032 18.0 3.0 0.053 14.1 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC40428.1 - 0.029 14.4 1.2 0.093 12.7 0.2 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding Hydrolase_4 PF12146.8 EFC40429.1 - 6.3e-11 42.0 0.0 4.6e-08 32.6 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydro_lipase PF04083.16 EFC40429.1 - 4.1e-10 39.1 0.0 1.4e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFC40429.1 - 7.5e-09 35.6 2.0 6e-08 32.6 2.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC40429.1 - 2.8e-05 24.8 0.0 6e-05 23.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EFC40429.1 - 0.0025 17.7 0.0 0.0059 16.5 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase LCAT PF02450.15 EFC40429.1 - 0.0034 16.6 0.1 0.0062 15.7 0.1 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF1749 PF08538.10 EFC40429.1 - 0.024 13.8 0.0 0.053 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DLH PF01738.18 EFC40429.1 - 0.04 13.4 0.1 0.082 12.4 0.1 1.4 1 0 0 1 1 1 0 Dienelactone hydrolase family LIDHydrolase PF10230.9 EFC40429.1 - 0.044 13.3 0.2 0.11 12.0 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase DUF900 PF05990.12 EFC40429.1 - 0.074 12.6 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF829 PF05705.14 EFC40429.1 - 0.79 9.6 4.8 1.6 8.6 0.1 3.0 3 1 1 4 4 4 0 Eukaryotic protein of unknown function (DUF829) NUDIX PF00293.28 EFC40430.1 - 2.2e-22 79.5 0.0 2.6e-22 79.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain OS-D PF03392.13 EFC40431.1 - 0.017 15.2 3.7 0.15 12.1 1.5 2.2 2 0 0 2 2 2 0 Insect pheromone-binding family, A10/OS-D SMAP PF15477.6 EFC40431.1 - 1.5 9.8 7.7 19 6.3 7.7 2.5 1 1 0 1 1 1 0 Small acidic protein family Elongin_A PF06881.11 EFC40431.1 - 6.4 7.4 11.2 7.8 7.1 9.8 1.9 2 1 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 EFC40432.1 - 1.4e-05 24.8 3.5 3.9e-05 23.4 0.2 3.4 4 0 0 4 4 4 1 F-box domain F-box-like PF12937.7 EFC40432.1 - 0.014 15.3 0.1 0.041 13.8 0.1 1.8 1 0 0 1 1 1 0 F-box-like DUF2304 PF10066.9 EFC40432.1 - 0.38 11.0 8.8 0.079 13.2 5.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) RNA_POL_M_15KD PF02150.16 EFC40432.1 - 0.72 9.8 5.1 0.81 9.6 0.2 2.6 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit Diphthamide_syn PF01866.17 EFC40433.1 - 1e-72 245.2 1.3 1.6e-72 244.6 1.0 1.4 2 0 0 2 2 2 1 Putative diphthamide synthesis protein TPR_2 PF07719.17 EFC40434.1 - 3.7e-12 45.4 6.9 0.0074 16.3 0.0 8.6 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40434.1 - 1.8e-09 37.0 3.4 0.047 13.5 0.0 7.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40434.1 - 5e-07 29.4 0.4 0.18 12.1 0.1 5.8 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40434.1 - 6.8e-06 25.7 0.1 0.02 14.6 0.0 4.7 5 0 0 5 5 5 1 TPR repeat TPR_16 PF13432.6 EFC40434.1 - 1.5e-05 25.5 0.0 0.027 15.1 0.0 3.5 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40434.1 - 0.00079 19.9 0.1 15 6.2 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40434.1 - 0.0011 19.6 0.1 1.4 9.9 0.0 4.7 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40434.1 - 0.0028 17.9 0.1 29 5.1 0.0 5.1 5 1 1 6 6 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFC40434.1 - 0.027 14.5 4.0 0.093 12.8 1.9 2.6 2 0 0 2 2 2 0 Putative TPR-like repeat F-box PF00646.33 EFC40434.1 - 0.039 13.9 0.0 0.091 12.7 0.0 1.6 1 0 0 1 1 1 0 F-box domain TPR_6 PF13174.6 EFC40434.1 - 0.086 13.5 0.3 1.6e+02 3.2 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3697 PF12478.8 EFC40434.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-associated protein 2 7TMR-HDED PF07697.11 EFC40434.1 - 0.16 12.1 0.6 1.6 8.8 0.0 2.7 3 0 0 3 3 3 0 7TM-HD extracellular DUF4756 PF15948.5 EFC40435.1 - 0.034 14.0 0.6 0.034 14.0 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4756) ESM4 PF15952.5 EFC40435.1 - 8.5 6.8 11.1 4.1 7.8 0.5 2.6 3 0 0 3 3 3 0 Enhancer of split M4 family Pkinase PF00069.25 EFC40436.1 - 7e-66 222.3 0.0 1.2e-65 221.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40436.1 - 1.6e-37 129.2 0.0 3.1e-37 128.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC40436.1 - 5.5e-09 35.7 0.0 1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC40436.1 - 0.012 14.4 0.0 0.012 14.4 0.0 3.6 4 2 0 4 4 4 0 Fungal protein kinase SNF2_N PF00176.23 EFC40437.1 - 5.8e-44 150.2 0.1 1e-42 146.1 0.1 2.7 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC40437.1 - 4.8e-20 72.0 0.0 6.8e-17 61.8 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 EFC40437.1 - 3.4e-10 40.2 0.0 3.4e-10 40.2 0.0 3.9 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFC40437.1 - 5.9e-05 22.1 0.0 0.00012 21.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 OMPdecase PF00215.24 EFC40438.1 - 1.3e-66 224.5 0.0 2.6e-66 223.5 0.0 1.5 2 0 0 2 2 2 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 EFC40438.1 - 1.2e-05 24.9 0.0 2.7e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DUF5383 PF17355.2 EFC40438.1 - 0.0034 17.7 1.9 0.0092 16.4 1.9 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5383) CHCH PF06747.13 EFC40439.1 - 0.017 15.3 1.2 0.017 15.3 1.2 2.7 3 0 0 3 3 3 0 CHCH domain CX9C PF16860.5 EFC40439.1 - 0.18 11.8 2.4 7.6 6.6 1.0 2.7 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, AAA_7 PF12775.7 EFC40441.1 - 0.001 18.6 4.4 0.084 12.4 0.1 4.6 5 0 0 5 5 5 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFC40441.1 - 0.041 14.1 0.1 5.4 7.3 0.0 4.2 3 0 0 3 3 3 0 AAA domain Coat_F PF07875.12 EFC40441.1 - 0.42 10.9 2.9 18 5.6 0.0 3.6 2 1 1 3 3 3 0 Coat F domain ACT_4 PF13291.6 EFC40441.1 - 4.1 8.1 9.8 4.8 7.8 0.4 4.1 3 0 0 3 3 3 0 ACT domain ubiquitin PF00240.23 EFC40442.1 - 1.3e-61 204.3 6.2 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC40442.1 - 1.6e-29 101.5 8.1 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC40442.1 - 6e-09 36.2 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC40442.1 - 1.2e-08 34.7 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC40442.1 - 1.8e-08 34.5 0.3 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC40442.1 - 7.1e-07 29.5 1.4 0.034 14.5 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC40442.1 - 9.9e-07 29.3 0.1 0.016 15.7 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC40442.1 - 0.00019 21.4 6.8 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain ProRS-C_2 PF09181.10 EFC40442.1 - 0.074 13.2 2.1 6.2 7.0 0.4 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal bPH_3 PF14470.6 EFC40442.1 - 0.093 13.1 1.0 0.73 10.2 0.4 2.4 2 1 0 2 2 2 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC40442.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain DUF3861 PF12977.7 EFC40442.1 - 0.14 12.3 0.6 2.2 8.5 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) PI3K_rbd PF00794.18 EFC40442.1 - 0.21 11.8 1.7 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain GST_C_3 PF14497.6 EFC40443.1 - 7.4e-17 61.4 0.8 1.2e-16 60.7 0.8 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC40443.1 - 9.2e-07 29.0 0.9 1.8e-06 28.1 0.8 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC40443.1 - 8.3e-06 26.1 0.0 2.8e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC40443.1 - 0.0023 18.2 0.0 0.011 16.1 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC40443.1 - 0.032 14.3 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain C2 PF00168.30 EFC40444.1 - 1.9e-09 37.7 0.2 7e-09 35.9 0.0 2.1 2 0 0 2 2 2 1 C2 domain DUF1635 PF07795.11 EFC40444.1 - 4.7 7.0 10.7 0.11 12.4 3.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DDHD PF02862.17 EFC40444.1 - 8.9 6.4 10.3 0.29 11.2 2.4 2.1 2 0 0 2 2 2 0 DDHD domain F-box-like PF12937.7 EFC40446.1 - 0.037 13.9 0.1 0.075 12.9 0.1 1.4 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC40446.1 - 0.047 13.6 0.1 0.091 12.7 0.1 1.5 1 0 0 1 1 1 0 F-box domain OAD_gamma PF04277.13 EFC40449.1 - 0.073 13.7 4.5 1.4 9.6 0.9 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain TarH PF02203.15 EFC40449.1 - 4.7 7.1 6.1 0.44 10.4 0.1 2.2 2 0 0 2 2 2 0 Tar ligand binding domain homologue Adaptin_N PF01602.20 EFC40450.1 - 7.2e-70 236.0 16.4 7.2e-70 236.0 16.4 1.7 2 0 0 2 2 2 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 EFC40450.1 - 1.3e-52 177.1 2.0 2.1e-52 176.5 0.1 2.5 3 0 0 3 3 3 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 EFC40450.1 - 1.5e-49 167.5 1.5 2.4e-49 166.8 0.2 2.2 2 0 0 2 2 2 1 Coatomer beta C-terminal region Cnd1 PF12717.7 EFC40450.1 - 7.9e-09 35.8 0.2 7.9e-09 35.8 0.2 5.0 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC40450.1 - 3.3e-05 24.2 0.1 0.31 11.5 0.0 3.9 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 EFC40450.1 - 0.068 13.5 0.3 22 5.6 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat TAN PF11640.8 EFC40450.1 - 0.08 13.1 4.1 1.2 9.3 0.0 4.0 3 1 0 3 3 3 0 Telomere-length maintenance and DNA damage repair TRAF_BIRC3_bd PF16673.5 EFC40450.1 - 0.23 11.3 2.4 0.36 10.7 0.7 2.3 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain Epimerase PF01370.21 EFC40451.1 - 1.1e-17 64.4 0.0 1.6e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC40451.1 - 2e-16 59.9 0.0 3.2e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC40451.1 - 2.3e-14 53.2 0.0 3.1e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFC40451.1 - 8.4e-07 28.7 0.0 1.8e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFC40451.1 - 4.7e-05 23.4 0.0 0.0036 17.2 0.0 2.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC40451.1 - 0.00017 21.3 0.0 0.0021 17.7 0.0 2.3 2 0 0 2 2 2 1 NmrA-like family DUF4615 PF15393.6 EFC40452.1 - 7.5e-24 84.9 9.6 9.4e-24 84.6 9.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4615) PNTB PF02233.16 EFC40452.1 - 0.085 11.8 0.6 0.11 11.4 0.6 1.1 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit RcpC PF16976.5 EFC40452.1 - 0.23 11.5 3.6 0.32 11.1 3.6 1.2 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB DUF4337 PF14235.6 EFC40452.1 - 6.7 6.8 9.3 9.3 6.3 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Prok-TraM PF09228.10 EFC40453.1 - 0.11 12.9 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic Transcriptional repressor TraM TraP PF07296.11 EFC40453.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 TraP protein DUF1117 PF06547.12 EFC40453.1 - 5.3 7.6 7.2 10 6.7 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) CAMSAP_CKK PF08683.11 EFC40456.1 - 0.024 14.8 0.0 0.056 13.6 0.0 1.6 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated LRR_8 PF13855.6 EFC40457.1 - 8.4e-26 89.5 13.6 4.6e-08 32.7 4.1 5.1 4 1 1 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 EFC40457.1 - 2.8e-25 86.2 21.7 3.2e-05 23.6 0.0 10.1 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC40457.1 - 8.5e-20 70.5 20.9 0.00055 20.3 0.9 7.2 4 2 3 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40457.1 - 4.2e-09 35.7 13.0 7.9 7.5 0.1 9.2 7 3 1 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC40457.1 - 4.3e-07 29.6 6.8 0.00035 20.1 0.6 3.5 1 1 2 3 3 3 2 Leucine-rich repeat Sel1 PF08238.12 EFC40458.1 - 8e-97 315.5 41.2 9e-11 42.1 0.5 12.1 12 0 0 12 12 12 12 Sel1 repeat IrmA PF18673.1 EFC40458.1 - 0.11 12.6 0.1 7 6.8 0.0 2.6 2 0 0 2 2 2 0 interleukin receptor mimic protein A TPR_7 PF13176.6 EFC40458.1 - 0.6 10.3 12.9 2.2 8.5 0.1 6.3 8 0 0 8 8 8 0 Tetratricopeptide repeat TCP PF03634.13 EFC40458.1 - 1.3 9.5 6.1 89 3.6 0.1 4.4 2 1 1 3 3 3 0 TCP family transcription factor DUF4441 PF14536.6 EFC40458.1 - 3 8.1 10.2 10 6.3 0.0 4.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4441) MIT PF04212.18 EFC40458.1 - 3.2 7.9 26.4 11 6.2 0.1 8.7 10 0 0 10 10 10 0 MIT (microtubule interacting and transport) domain NHL PF01436.21 EFC40459.1 - 3.7e-15 55.1 6.8 3.9e-05 23.5 0.0 5.6 5 1 0 5 5 5 3 NHL repeat SGL PF08450.12 EFC40459.1 - 1.5e-06 28.0 0.2 0.00061 19.4 0.5 2.8 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC40459.1 - 2.4e-05 24.5 0.0 1 9.6 0.0 3.3 3 0 0 3 3 3 2 Arylesterase DUF5128 PF17170.4 EFC40459.1 - 0.0083 15.3 0.5 0.061 12.5 0.1 2.4 2 1 0 3 3 3 1 6-bladed beta-propeller SapB_1 PF05184.15 EFC40461.1 - 6.8e-06 26.0 13.5 2.8e-05 24.0 2.5 3.1 3 0 0 3 3 3 2 Saposin-like type B, region 1 SapB_2 PF03489.17 EFC40461.1 - 0.00048 20.2 7.8 0.0032 17.6 0.4 3.4 3 1 0 3 3 3 2 Saposin-like type B, region 2 DSPc PF00782.20 EFC40462.1 - 1.3e-33 115.6 0.0 2e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 EFC40462.1 - 4.9e-07 29.6 0.1 7.6e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 EFC40462.1 - 0.00024 20.8 0.2 0.00043 19.9 0.1 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFC40462.1 - 0.00076 19.8 0.0 0.0014 18.9 0.0 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFC40462.1 - 0.017 15.3 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Acetyltransf_10 PF13673.7 EFC40463.1 - 2.2e-07 30.9 0.0 4.8e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC40463.1 - 9.6e-07 29.0 0.0 1.6e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC40463.1 - 2.5e-06 27.8 0.0 6.7e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC40463.1 - 3.3e-05 24.0 0.0 0.00036 20.6 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EFC40463.1 - 4.8e-05 23.0 0.0 0.0002 21.0 0.0 1.9 2 0 0 2 2 2 1 GNAT acetyltransferase FR47 PF08445.10 EFC40463.1 - 6.7e-05 22.8 0.0 0.00049 20.0 0.0 2.4 3 0 0 3 3 3 1 FR47-like protein EF-hand_6 PF13405.6 EFC40464.1 - 4.9e-20 69.7 6.8 4.8e-07 29.2 0.3 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EFC40464.1 - 2.1e-19 67.5 12.2 7.8e-07 28.2 0.5 4.3 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC40464.1 - 1.4e-16 60.7 13.5 7.8e-10 39.1 4.2 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC40464.1 - 7.5e-10 37.9 11.7 4.5e-06 25.9 0.2 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC40464.1 - 8.9e-09 35.1 7.2 0.016 15.1 0.6 4.4 3 2 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC40464.1 - 0.00013 22.2 7.6 0.035 14.4 3.4 2.9 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFC40464.1 - 0.019 15.3 0.7 1.7 9.0 0.0 2.7 2 1 0 2 2 2 0 EF-hand domain Sirohm_synth_C PF14823.6 EFC40464.1 - 0.064 12.9 0.5 1.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal EF-hand_10 PF14788.6 EFC40464.1 - 0.065 13.1 7.7 0.91 9.4 0.6 3.4 2 1 1 3 3 3 0 EF hand Transcript_VP30 PF11507.8 EFC40464.1 - 0.073 13.1 0.1 0.96 9.5 0.0 2.3 2 0 0 2 2 2 0 Ebola virus-specific transcription factor VP30 tRNA_lig_kinase PF08303.11 EFC40464.1 - 0.34 11.0 6.2 0.087 12.9 2.6 1.7 2 0 0 2 2 2 0 tRNA ligase kinase domain Caleosin PF05042.13 EFC40464.1 - 3 7.7 7.5 5.8 6.8 0.2 3.3 2 2 1 3 3 3 0 Caleosin related protein p25-alpha PF05517.12 EFC40464.1 - 3.9 7.6 13.3 34 4.6 11.7 2.8 1 1 1 2 2 2 0 p25-alpha ABC_tran PF00005.27 EFC40465.1 - 3.4e-26 92.4 0.0 6.8e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFC40465.1 - 5.3e-17 62.0 48.0 3e-16 59.5 39.6 2.5 1 1 1 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 EFC40465.1 - 1.4e-06 28.4 2.0 0.046 13.5 0.4 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC40465.1 - 0.017 14.5 0.0 0.21 11.0 0.0 2.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Ac81 PF05820.11 EFC40465.1 - 0.017 14.7 0.1 0.017 14.7 0.1 2.5 4 0 0 4 4 4 0 Baculoviridae AC81 AAA_23 PF13476.6 EFC40465.1 - 0.062 13.8 0.0 0.062 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain MitMem_reg PF13012.6 EFC40466.1 - 3.5e-31 107.9 0.6 7.6e-31 106.8 0.6 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFC40466.1 - 4.4e-31 107.3 0.7 3.9e-30 104.2 0.0 2.3 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TMPIT PF07851.13 EFC40466.1 - 0.13 11.5 0.0 0.13 11.5 0.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein DUF4065 PF13274.6 EFC40466.1 - 0.45 11.4 3.9 0.33 11.9 0.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4065) Filamin PF00630.19 EFC40467.1 - 1.4e-39 135.1 9.6 1.9e-14 54.3 0.0 5.9 6 0 0 6 6 5 5 Filamin/ABP280 repeat RasGAP PF00616.19 EFC40467.1 - 8.4e-37 126.9 6.2 8.4e-37 126.9 6.2 2.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 EFC40467.1 - 1.4e-14 54.2 0.1 1.4e-14 54.2 0.1 2.8 3 0 0 3 3 3 1 Calponin homology (CH) domain RasGAP_C PF03836.15 EFC40467.1 - 1.2e-13 51.3 20.7 1.2e-13 51.3 20.7 3.1 3 0 0 3 3 3 1 RasGAP C-terminus Invasin_D3 PF09134.10 EFC40467.1 - 8.5e-10 38.8 0.2 0.046 14.0 0.0 4.6 4 0 0 4 4 4 2 Invasin, domain 3 Big_1 PF02369.16 EFC40467.1 - 6.4e-05 22.9 0.3 0.0049 16.9 0.2 3.9 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 1) YtkA PF13115.6 EFC40467.1 - 0.0063 17.1 0.2 28 5.4 0.0 4.5 4 0 0 4 4 4 0 YtkA-like DUF5011 PF16403.5 EFC40467.1 - 0.015 15.4 5.2 4.5 7.5 0.1 4.3 4 0 0 4 4 3 0 Domain of unknown function (DUF5011) CAMSAP_CH PF11971.8 EFC40467.1 - 0.022 14.6 0.0 0.074 12.9 0.0 2.0 1 0 0 1 1 1 0 CAMSAP CH domain CarboxypepD_reg PF13620.6 EFC40467.1 - 0.023 15.0 0.3 1.3 9.3 0.1 3.0 3 0 0 3 3 3 0 Carboxypeptidase regulatory-like domain Cadherin_5 PF17892.1 EFC40467.1 - 0.027 14.4 1.5 12 5.9 0.0 3.5 3 0 0 3 3 3 0 Cadherin-like domain ERM PF00769.19 EFC40467.1 - 0.16 11.7 18.9 0.34 10.7 1.0 2.7 2 0 0 2 2 2 0 Ezrin/radixin/moesin family GIIM PF08388.11 EFC40467.1 - 0.2 11.7 1.7 0.51 10.4 0.6 2.2 2 0 0 2 2 2 0 Group II intron, maturase-specific domain Big_6 PF17936.1 EFC40467.1 - 0.24 11.7 1.3 12 6.3 0.1 4.1 3 1 0 3 3 3 0 Bacterial Ig domain RNA_pol_Rpb1_6 PF04992.14 EFC40467.1 - 1.3 8.8 12.2 8.5 6.2 0.2 2.8 2 1 0 2 2 2 0 RNA polymerase Rpb1, domain 6 Phage_HK97_TLTM PF06120.11 EFC40467.1 - 6.4 5.9 18.9 0.17 11.0 11.6 2.1 2 0 0 2 2 2 0 Tail length tape measure protein DUF3827 PF12877.7 EFC40468.1 - 0.0013 17.3 0.8 0.0017 16.8 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) DUF4448 PF14610.6 EFC40468.1 - 0.012 15.4 0.2 0.021 14.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF3377 PF11857.8 EFC40468.1 - 1 9.4 3.4 2.9 7.9 3.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EFC40468.1 - 2 8.3 6.2 3.6 7.5 5.1 1.8 1 1 0 1 1 1 0 TMEM154 protein family LRR_6 PF13516.6 EFC40469.1 - 9.7e-08 31.5 0.1 0.027 14.5 0.0 2.7 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.7 EFC40469.1 - 0.001 19.4 0.0 0.013 15.9 0.0 2.5 3 0 0 3 3 3 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC40469.1 - 0.0018 18.0 0.0 0.0088 15.8 0.0 2.0 2 0 0 2 2 2 1 Leucine rich repeat F-box-like PF12937.7 EFC40469.1 - 0.0023 17.8 0.0 0.0049 16.7 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC40469.1 - 0.012 15.4 0.1 0.039 13.9 0.0 1.8 2 0 0 2 2 2 0 F-box domain Phospholip_B PF04916.13 EFC40470.1 - 2.5e-140 468.6 10.7 3.1e-140 468.3 10.7 1.0 1 0 0 1 1 1 1 Phospholipase B Biotin_lipoyl PF00364.22 EFC40471.1 - 5.9e-12 45.2 0.2 8.5e-12 44.7 0.2 1.2 1 0 0 1 1 1 1 Biotin-requiring enzyme PhoLip_ATPase_C PF16212.5 EFC40472.1 - 3.4e-61 207.1 19.1 3.4e-61 207.1 19.1 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal E1-E2_ATPase PF00122.20 EFC40472.1 - 1.2e-09 38.0 0.9 8.5e-09 35.2 0.1 2.5 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFC40472.1 - 5.3e-08 32.9 0.2 2.2e-05 24.5 0.0 3.2 2 1 0 2 2 2 2 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC40472.1 - 3e-07 30.9 1.6 0.024 14.9 0.4 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC40472.1 - 0.0004 20.2 0.2 0.0076 16.0 0.0 2.6 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Cadherin_3 PF16184.5 EFC40473.1 - 5.9e-09 35.9 0.4 1.4e-08 34.7 0.4 1.6 1 0 0 1 1 1 1 Cadherin-like Guanylate_cyc PF00211.20 EFC40474.1 - 5.1e-31 107.7 0.3 1.7e-30 106.0 0.1 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40474.1 - 2.3e-16 59.9 0.1 1e-15 57.9 0.1 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC40474.1 - 7.2e-11 42.1 0.0 2.2e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 PAS fold DUF21 PF01595.20 EFC40474.1 - 0.0062 16.3 2.7 1.3 8.7 0.8 2.8 2 0 0 2 2 2 2 Cyclin M transmembrane N-terminal domain PAS_10 PF13596.6 EFC40474.1 - 0.048 14.3 0.0 0.15 12.7 0.0 1.9 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 EFC40474.1 - 0.068 13.4 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 PAS fold Amnionless PF14828.6 EFC40474.1 - 0.097 11.5 0.6 0.78 8.5 0.1 2.3 3 0 0 3 3 3 0 Amnionless Patched PF02460.18 EFC40475.1 - 0.25 9.4 22.5 0.61 8.1 22.5 1.6 1 1 0 1 1 1 0 Patched family BTB_2 PF02214.22 EFC40477.1 - 1.1e-15 57.8 0.2 1.1e-15 57.8 0.2 2.2 2 1 0 2 2 2 1 BTB/POZ domain SPRY PF00622.28 EFC40477.1 - 1.2e-06 28.6 0.1 2.6e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 SPRY domain Golgin_A5 PF09787.9 EFC40477.1 - 0.094 12.2 18.2 0.13 11.7 18.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 EFC40477.1 - 0.22 11.0 6.8 0.36 10.4 6.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4279 PF14106.6 EFC40477.1 - 0.5 10.6 6.4 2.6 8.3 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) DUF3552 PF12072.8 EFC40477.1 - 0.52 9.7 22.8 3.2 7.1 23.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) UPF0242 PF06785.11 EFC40477.1 - 0.58 10.2 20.1 0.94 9.6 20.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Macoilin PF09726.9 EFC40477.1 - 0.92 8.0 12.9 1.3 7.5 12.9 1.1 1 0 0 1 1 1 0 Macoilin family FPP PF05911.11 EFC40477.1 - 1.6 6.8 19.4 2.2 6.4 19.4 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil TMPIT PF07851.13 EFC40477.1 - 1.9 7.7 10.5 2.8 7.1 10.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein FmdE PF02663.14 EFC40477.1 - 2.7 8.0 5.4 4.8 7.2 5.4 1.4 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Plk4_PB2 PF18409.1 EFC40477.1 - 3.3 8.4 7.7 15 6.3 1.9 2.4 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 Atg14 PF10186.9 EFC40477.1 - 5.6 5.9 11.5 7.7 5.5 11.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Presenilin PF01080.17 EFC40477.1 - 6.3 5.5 6.8 8.5 5.0 6.8 1.1 1 0 0 1 1 1 0 Presenilin LRR_4 PF12799.7 EFC40478.1 - 1.3e-11 44.5 15.3 1.4e-05 25.4 3.1 4.4 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC40478.1 - 2.2e-07 30.5 3.5 1.1e-05 25.0 0.3 2.6 1 1 1 2 2 2 2 Leucine-rich repeat LRR_8 PF13855.6 EFC40478.1 - 1.1e-06 28.3 13.7 1.8e-05 24.4 7.8 3.6 3 0 0 3 3 3 2 Leucine rich repeat DUF3224 PF11528.8 EFC40478.1 - 2.4e-05 24.2 1.9 2.1 8.2 0.0 5.5 6 0 0 6 6 6 1 Protein of unknown function (DUF3224) LRR_6 PF13516.6 EFC40478.1 - 0.6 10.3 10.4 5.2 7.4 0.3 5.7 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 EFC40478.1 - 4.5 8.2 11.4 55 4.9 0.8 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat DUF2838 PF10998.8 EFC40479.1 - 1.5e-38 131.4 10.5 1.5e-38 131.4 10.5 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Mucin PF01456.17 EFC40479.1 - 0.067 13.2 11.4 0.12 12.4 11.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein NUDE_C PF04880.13 EFC40479.1 - 1.3 9.5 9.1 2 8.9 9.1 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region CPSF_A PF03178.15 EFC40480.1 - 1.7e-71 241.2 0.0 3.7e-71 240.1 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 EFC40480.1 - 2.8e-40 138.4 4.0 3e-39 135.0 3.6 2.3 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Lactamase_B_6 PF16661.5 EFC40481.1 - 6.7e-48 162.7 2.2 1.1e-30 106.6 1.0 2.5 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EFC40481.1 - 1.9e-21 76.4 1.0 1.3e-20 73.7 0.6 2.7 2 1 0 2 2 2 1 Beta-Casp domain CPSF100_C PF13299.6 EFC40481.1 - 5.1e-18 65.8 6.3 1.5e-16 61.0 0.0 3.7 3 1 1 4 4 4 1 Cleavage and polyadenylation factor 2 C-terminal RMMBL PF07521.12 EFC40481.1 - 2.7e-10 40.0 0.0 1.1e-09 38.0 0.0 2.1 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 EFC40481.1 - 0.02 14.4 0.0 0.049 13.1 0.0 1.6 2 0 0 2 2 2 0 Beta-lactamase superfamily domain Glu_syn_central PF04898.14 EFC40481.1 - 0.038 13.5 0.2 0.13 11.7 0.1 1.8 2 0 0 2 2 2 0 Glutamate synthase central domain DUF2722 PF10846.8 EFC40481.1 - 1.7 7.5 7.8 0.42 9.5 4.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2722) vATP-synt_E PF01991.18 EFC40482.1 - 7.6e-50 169.1 22.1 8.5e-50 168.9 22.1 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit YjcB PF15940.5 EFC40482.1 - 0.059 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function Transket_pyr PF02779.24 EFC40483.1 - 3.5e-40 137.6 0.0 5.1e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFC40483.1 - 9.1e-37 125.7 0.1 1.6e-36 124.9 0.1 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EFC40483.1 - 0.0012 19.1 0.0 0.0021 18.3 0.0 1.4 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Kelch_1 PF01344.25 EFC40484.1 - 1.5e-27 94.9 8.5 3.4e-06 26.6 0.1 5.3 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 EFC40484.1 - 2.6e-25 87.9 7.5 3e-05 23.9 0.8 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_3 PF13415.6 EFC40484.1 - 3.4e-25 87.8 4.1 1.8e-09 37.6 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC40484.1 - 2.9e-23 81.6 6.3 6.8e-06 26.0 0.1 6.5 6 1 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC40484.1 - 3.2e-23 81.2 8.3 9.7e-08 32.0 0.1 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFC40484.1 - 1.7e-15 56.3 4.8 0.0012 18.8 0.0 5.7 6 0 0 6 6 6 4 Kelch motif NosL PF05573.12 EFC40484.1 - 0.0086 16.4 0.1 3.9 7.8 0.0 3.0 3 0 0 3 3 3 1 NosL DUF1668 PF07893.13 EFC40484.1 - 0.062 12.6 0.7 1 8.6 0.1 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1668) Sds3 PF08598.11 EFC40485.1 - 0.007 16.4 15.6 0.0085 16.1 13.5 2.3 1 1 1 2 2 2 1 Sds3-like Polbeta PF18765.1 EFC40486.1 - 0.00044 20.3 0.7 0.007 16.4 0.0 2.7 2 1 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase UvrD-helicase PF00580.21 EFC40486.1 - 0.0034 16.9 0.6 0.0048 16.5 0.6 1.3 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Rho_RNA_bind PF07497.12 EFC40486.1 - 0.099 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Rho termination factor, RNA-binding domain DUF5049 PF16468.5 EFC40486.1 - 0.21 11.5 1.0 0.44 10.5 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5049) EF1_GNE PF00736.19 EFC40487.1 - 3.9e-13 49.4 1.2 4.9e-13 49.1 0.2 1.6 1 1 1 2 2 2 1 EF-1 guanine nucleotide exchange domain GPW_gp25 PF04965.14 EFC40487.1 - 0.12 12.1 0.3 0.19 11.5 0.3 1.5 1 1 0 1 1 1 0 Gene 25-like lysozyme AAA PF00004.29 EFC40489.1 - 1e-41 142.4 0.0 2.4e-41 141.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC40489.1 - 1.5e-09 37.5 0.1 3.3e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFC40489.1 - 5.8e-06 26.3 0.0 2.1e-05 24.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC40489.1 - 1.8e-05 25.2 0.2 0.00018 22.0 0.2 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EFC40489.1 - 2.6e-05 24.4 0.0 6.2e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFC40489.1 - 3.1e-05 24.2 0.1 0.0045 17.3 0.0 2.8 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 EFC40489.1 - 0.00021 21.1 0.0 0.0011 18.8 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 EFC40489.1 - 0.00031 20.0 0.0 0.00059 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_28 PF13521.6 EFC40489.1 - 0.002 18.4 0.0 0.0036 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC40489.1 - 0.0036 17.5 0.0 0.0076 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC40489.1 - 0.0048 17.4 0.0 0.017 15.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain ATPase_2 PF01637.18 EFC40489.1 - 0.0055 16.6 0.0 0.6 10.0 0.0 2.4 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EFC40489.1 - 0.0074 16.7 0.0 0.016 15.6 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 EFC40489.1 - 0.0087 15.3 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 EFC40489.1 - 0.013 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFC40489.1 - 0.015 14.7 0.0 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFC40489.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFC40489.1 - 0.024 14.3 0.1 0.1 12.3 0.0 2.1 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EFC40489.1 - 0.025 14.1 0.0 0.059 12.9 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EFC40489.1 - 0.049 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFC40489.1 - 0.068 12.9 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 EFC40489.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 EFC40489.1 - 0.13 11.5 0.1 0.38 10.0 0.0 1.7 1 1 1 2 2 2 0 Zeta toxin Parvo_NS1 PF01057.17 EFC40489.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 cobW PF02492.19 EFC40489.1 - 0.14 11.7 0.0 1.2 8.7 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 EFC40489.1 - 0.19 11.3 0.1 0.71 9.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zn_clus PF00172.18 EFC40490.1 - 7.5e-08 32.4 10.9 1.3e-07 31.6 10.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain His_kinase PF06580.13 EFC40491.1 - 0.092 13.1 1.6 0.24 11.8 0.5 2.3 1 1 1 2 2 2 0 Histidine kinase DUF4116 PF13475.6 EFC40492.1 - 4.1 7.2 8.9 3.6 7.4 0.6 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4116) adh_short PF00106.25 EFC40493.1 - 3.3e-18 65.8 0.0 2.7e-10 40.0 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 EFC40493.1 - 5.7e-07 29.3 0.0 0.00013 21.6 0.0 2.7 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC40493.1 - 0.001 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 KR domain ScsC_N PF18312.1 EFC40493.1 - 0.084 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Copper resistance protein ScsC N-terminal domain V_ATPase_I PF01496.19 EFC40495.1 - 2e-269 896.0 0.6 2.3e-269 895.8 0.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family OmpH PF03938.14 EFC40495.1 - 0.1 13.0 2.8 0.06 13.7 0.6 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TACC_C PF05010.14 EFC40495.1 - 1.4 8.6 6.3 0.69 9.7 3.8 1.7 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4200 PF13863.6 EFC40495.1 - 2.7 8.4 6.9 1.4 9.4 3.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) GGACT PF06094.12 EFC40496.1 - 1.8e-09 38.3 0.0 2.7e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like HCNGP PF07818.13 EFC40496.1 - 0.089 13.4 0.0 3.5 8.3 0.0 2.2 2 0 0 2 2 2 0 HCNGP-like protein SR-25 PF10500.9 EFC40497.1 - 0.0041 16.8 6.6 0.0057 16.3 6.6 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Izumo-Ig PF16706.5 EFC40499.1 - 0.018 15.1 0.2 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain CxxCxxCC PF03692.15 EFC40499.1 - 0.14 12.9 0.2 0.4 11.4 0.2 1.7 1 0 0 1 1 1 0 Putative zinc- or iron-chelating domain PRKCSH-like PF12999.7 EFC40500.1 - 3.3e-37 128.0 12.2 3.3e-37 128.0 12.2 1.4 1 1 0 1 1 1 1 Glucosidase II beta subunit-like Macoilin PF09726.9 EFC40500.1 - 4.2e-05 22.3 3.9 5.3e-05 22.0 3.9 1.0 1 0 0 1 1 1 1 Macoilin family Ldl_recept_a PF00057.18 EFC40500.1 - 0.00065 19.9 16.3 0.037 14.2 4.1 2.6 2 0 0 2 2 2 2 Low-density lipoprotein receptor domain class A Spc7 PF08317.11 EFC40500.1 - 0.001 18.0 9.1 0.0016 17.4 9.1 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Fez1 PF06818.15 EFC40500.1 - 0.0047 17.4 5.3 0.0071 16.8 5.3 1.2 1 0 0 1 1 1 1 Fez1 DUF4795 PF16043.5 EFC40500.1 - 0.0058 16.3 5.3 0.0099 15.5 5.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) Exonuc_VII_L PF02601.15 EFC40500.1 - 0.039 13.5 0.6 0.051 13.1 0.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 EFC40500.1 - 0.042 13.9 0.1 0.066 13.3 0.1 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2681 PF10883.8 EFC40500.1 - 0.18 12.2 4.4 1.6 9.2 5.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Sushi_2 PF09014.10 EFC40500.1 - 0.2 11.5 5.5 0.11 12.5 2.5 2.0 1 1 1 2 2 2 0 Beta-2-glycoprotein-1 fifth domain DUF4407 PF14362.6 EFC40500.1 - 0.58 9.4 5.0 0.96 8.7 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_GP20 PF06810.11 EFC40500.1 - 0.94 9.3 12.8 1.6 8.5 12.0 1.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 SlyX PF04102.12 EFC40500.1 - 1 10.0 7.8 47 4.7 7.3 2.5 1 1 1 2 2 2 0 SlyX TMPIT PF07851.13 EFC40500.1 - 2.1 7.5 9.8 3.4 6.8 9.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein OmpH PF03938.14 EFC40500.1 - 5.4 7.4 13.3 9.1 6.6 13.0 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DNA_pol_E_B PF04042.16 EFC40501.1 - 4.6e-42 143.8 0.0 6.4e-42 143.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 EFC40501.1 - 3.8e-18 65.9 0.4 1.2e-17 64.3 0.0 1.9 3 0 0 3 3 3 1 DNA polymerase delta subunit OB-fold domain Tubulin_C PF03953.17 EFC40502.1 - 4.2e-19 69.0 0.0 9.1e-19 67.9 0.0 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 EFC40502.1 - 0.0001 22.6 0.0 0.0002 21.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain ArsA_ATPase PF02374.15 EFC40503.1 - 9.7e-106 353.4 0.4 1.1e-105 353.2 0.4 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 EFC40503.1 - 2.2e-13 50.5 1.1 2.3e-12 47.2 0.0 2.5 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 EFC40503.1 - 8.5e-11 42.0 0.1 2.8e-10 40.3 0.1 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EFC40503.1 - 3.1e-06 26.8 0.2 9.7e-05 21.9 0.1 2.5 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 EFC40503.1 - 9.7e-06 25.2 2.2 0.00013 21.5 0.1 2.8 3 0 0 3 3 3 1 NUBPL iron-transfer P-loop NTPase NB-ARC PF00931.22 EFC40503.1 - 2.2e-05 23.8 0.0 5e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain CBP_BcsQ PF06564.12 EFC40503.1 - 2.3e-05 24.0 0.0 8.1e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 EFC40503.1 - 2.4e-05 24.1 0.0 0.0072 16.0 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PIF1 PF05970.14 EFC40503.1 - 0.0013 18.0 0.6 0.054 12.7 0.0 2.4 3 0 0 3 3 3 1 PIF1-like helicase AAA_18 PF13238.6 EFC40503.1 - 0.0028 18.2 0.3 0.046 14.3 0.2 2.8 2 2 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFC40503.1 - 0.0029 16.9 0.0 0.0063 15.8 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 EFC40503.1 - 0.0099 15.5 0.0 0.064 12.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EFC40503.1 - 0.023 14.5 0.1 0.07 12.9 0.1 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein baeRF_family6 PF18848.1 EFC40503.1 - 0.042 14.3 0.0 0.067 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 AAA_16 PF13191.6 EFC40503.1 - 0.046 14.1 0.0 0.077 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFC40503.1 - 0.05 13.3 0.1 0.19 11.4 0.1 2.0 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 EFC40503.1 - 0.084 11.8 0.0 0.19 10.7 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB T2SSE PF00437.20 EFC40503.1 - 0.11 11.6 0.0 0.47 9.5 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein DnaB_C PF03796.15 EFC40503.1 - 0.14 11.5 0.0 0.37 10.1 0.0 1.7 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain EF-hand_6 PF13405.6 EFC40504.1 - 1.1e-12 46.8 2.2 0.00017 21.2 0.2 4.3 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 EFC40504.1 - 1.2e-12 48.1 11.8 3.2e-06 27.5 0.4 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC40504.1 - 3.1e-11 42.0 5.0 5.9e-05 22.3 0.3 4.6 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 EFC40504.1 - 2.8e-07 29.7 2.0 0.0023 17.4 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC40504.1 - 2.1e-05 24.2 6.0 0.0064 16.3 0.1 3.9 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC40504.1 - 0.048 14.0 0.1 4.6 7.6 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RPN7 PF10602.9 EFC40505.1 - 3.2e-57 193.0 1.0 6.2e-57 192.1 1.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 EFC40505.1 - 4.8e-15 56.0 1.4 8.4e-15 55.2 0.2 2.0 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 EFC40505.1 - 0.034 14.3 0.3 1.3 9.3 0.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat HSCB_C PF07743.13 EFC40505.1 - 0.052 14.0 1.0 0.19 12.3 1.0 2.0 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain TPR_8 PF13181.6 EFC40505.1 - 0.18 12.1 0.9 0.96 9.8 0.9 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat adh_short PF00106.25 EFC40506.1 - 1.8e-50 171.1 0.0 2.4e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC40506.1 - 1.2e-34 119.9 0.0 1.5e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC40506.1 - 1.5e-08 34.8 0.0 2.2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFC40506.1 - 2.5e-06 27.1 0.0 3.6e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 EFC40506.1 - 0.00021 20.9 0.0 0.00042 19.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC40506.1 - 0.00068 19.6 0.0 0.00093 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC40506.1 - 0.0085 15.7 0.1 0.019 14.5 0.2 1.5 2 0 0 2 2 2 1 NmrA-like family RmlD_sub_bind PF04321.17 EFC40506.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain CLAMP PF14769.6 EFC40507.1 - 3.4e-31 107.6 6.2 7.4e-31 106.5 6.2 1.6 1 0 0 1 1 1 1 Flagellar C1a complex subunit C1a-32 Dynamitin PF04912.14 EFC40507.1 - 1.5e-05 24.5 5.6 3e-05 23.5 5.6 1.4 1 0 0 1 1 1 1 Dynamitin Atg8 PF02991.16 EFC40507.1 - 0.016 15.4 0.6 0.016 15.4 0.6 2.2 2 0 0 2 2 2 0 Autophagy protein Atg8 ubiquitin like FlaC_arch PF05377.11 EFC40507.1 - 0.023 15.1 6.7 0.21 12.0 0.4 3.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) HSBP1 PF06825.12 EFC40507.1 - 0.025 14.5 4.1 0.66 9.9 0.3 2.9 3 0 0 3 3 3 0 Heat shock factor binding protein 1 HTH_WhiA PF02650.14 EFC40507.1 - 0.026 14.8 6.2 0.12 12.7 0.0 3.0 3 0 0 3 3 3 0 WhiA C-terminal HTH domain SUIM_assoc PF16619.5 EFC40507.1 - 0.049 13.7 4.8 0.089 12.9 4.8 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 MerR-DNA-bind PF09278.11 EFC40507.1 - 0.13 12.8 0.3 0.13 12.8 0.3 3.8 4 0 0 4 4 4 0 MerR, DNA binding TFIID_30kDa PF03540.13 EFC40508.1 - 2.3e-17 62.7 0.0 3.5e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 EFC40508.1 - 7.3e-06 25.9 0.1 2e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 Bromodomain associated Ribosomal_L35Ae PF01247.18 EFC40509.1 - 4.6e-37 126.1 0.1 6.2e-37 125.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 EFC40509.1 - 1.6e-05 25.0 0.1 0.028 14.6 0.1 2.2 2 0 0 2 2 2 2 RimM N-terminal domain GTP_EFTU PF00009.27 EFC40510.1 - 6.8e-50 169.3 0.0 1.6e-49 168.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 EFC40510.1 - 7.9e-46 154.6 2.0 1.5e-45 153.8 2.0 1.5 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 EFC40510.1 - 1.6e-23 82.6 0.2 3e-23 81.7 0.2 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFC40510.1 - 2.7e-08 34.1 0.0 1.3e-07 31.8 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC40510.1 - 0.00048 20.2 0.0 0.0015 18.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 EFC40510.1 - 0.00089 19.3 0.0 0.0032 17.5 0.0 2.0 1 1 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 EFC40510.1 - 0.0046 16.6 0.1 0.015 14.9 0.0 1.9 2 0 0 2 2 2 1 Ras family RF3_C PF16658.5 EFC40510.1 - 0.0083 16.0 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 EFC40510.1 - 0.016 14.6 0.0 0.048 13.1 0.0 1.9 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit ENTH PF01417.20 EFC40511.1 - 0.0014 18.7 0.2 0.67 10.0 0.2 3.4 2 1 0 2 2 2 2 ENTH domain Thiamine_BP PF01910.17 EFC40511.1 - 0.062 13.2 1.4 0.27 11.2 0.9 2.3 1 1 1 2 2 2 0 Thiamine-binding protein Abi_C PF14355.6 EFC40511.1 - 0.46 10.6 3.6 22 5.2 0.1 4.2 4 1 1 5 5 5 0 Abortive infection C-terminus DUF4407 PF14362.6 EFC40511.1 - 3.8 6.8 8.8 10 5.4 8.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4064 PF13273.6 EFC40512.1 - 0.024 14.9 9.5 0.034 14.4 6.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) DUF4131 PF13567.6 EFC40512.1 - 0.069 12.8 1.9 0.084 12.5 0.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Pox_E2-like PF04497.12 EFC40512.1 - 0.1 11.0 0.7 0.12 10.8 0.7 1.0 1 0 0 1 1 1 0 Poxviridae protein Claudin_2 PF13903.6 EFC40512.1 - 0.18 11.6 3.9 0.14 11.9 2.8 1.4 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Tetraspanin PF00335.20 EFC40512.1 - 0.7 9.6 10.4 0.47 10.1 8.6 1.6 1 1 0 1 1 1 0 Tetraspanin family OAD_gamma PF04277.13 EFC40512.1 - 0.92 10.1 0.0 0.92 10.1 0.0 3.2 3 1 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DotU PF09850.9 EFC40513.1 - 0.019 14.7 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 Type VI secretion system protein DotU Uds1 PF15456.6 EFC40513.1 - 4.2 7.5 6.3 0.31 11.2 0.6 1.9 2 1 0 2 2 2 0 Up-regulated During Septation Spec3 PF15795.5 EFC40515.1 - 1.5e-10 41.5 16.6 2.1e-09 37.8 16.6 1.9 1 1 0 1 1 1 1 Ectodermal ciliogenesis protein Phage_holin_3_6 PF07332.11 EFC40515.1 - 0.11 12.5 3.1 0.14 12.2 3.1 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF5493 PF17597.2 EFC40515.1 - 0.18 12.1 4.8 0.84 9.9 0.6 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5493) TisB_toxin PF13939.6 EFC40515.1 - 5.5 6.9 8.6 9.8 6.1 1.5 2.5 2 0 0 2 2 2 0 Toxin TisB, type I toxin-antitoxin system Clathrin PF00637.20 EFC40517.1 - 2.8e-09 37.0 19.9 7.7e-07 29.1 0.3 5.3 4 1 1 5 5 5 2 Region in Clathrin and VPS Vps39_2 PF10367.9 EFC40517.1 - 9.8e-07 29.2 0.0 3.5e-06 27.4 0.0 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 WD40 PF00400.32 EFC40517.1 - 0.003 18.4 0.0 0.011 16.6 0.0 2.0 1 0 0 1 1 1 1 WD domain, G-beta repeat SDA1 PF05285.12 EFC40517.1 - 3.2 7.1 45.1 0.0073 15.8 26.3 3.8 4 0 0 4 4 4 0 SDA1 DUF913 PF06025.12 EFC40517.1 - 9.7 5.1 10.1 26 3.7 10.1 1.7 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Erythro-docking PF09277.11 EFC40518.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Erythronolide synthase, docking MJ1316 PF04457.12 EFC40519.1 - 6.9e-08 33.1 0.0 1.9e-07 31.7 0.0 1.8 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain SprA-related PF12118.8 EFC40519.1 - 0.28 10.3 4.9 0.46 9.6 4.9 1.3 1 0 0 1 1 1 0 SprA-related family COX16 PF14138.6 EFC40519.1 - 9 6.9 10.0 21 5.7 0.1 2.6 2 1 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 CwfJ_C_1 PF04677.15 EFC40521.1 - 8.6e-32 109.6 2.5 1.8e-31 108.6 2.5 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 EFC40521.1 - 3.6e-19 69.5 0.2 3.6e-19 69.5 0.2 2.6 3 0 0 3 3 3 1 Protein similar to CwfJ C-terminus 2 PTCB-BRCT PF12738.7 EFC40522.1 - 2.1e-10 40.4 0.1 4.1e-10 39.5 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EFC40522.1 - 2.5e-09 37.4 0.0 8.6e-09 35.7 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC40522.1 - 0.0013 19.1 0.0 0.0033 17.8 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFC40522.1 - 0.034 14.5 0.3 0.14 12.5 0.0 2.1 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain LRR19-TM PF15176.6 EFC40523.1 - 0.017 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain MSC PF09402.10 EFC40523.1 - 0.018 14.5 0.4 0.018 14.5 0.4 1.8 3 0 0 3 3 3 0 Man1-Src1p-C-terminal domain CD34_antigen PF06365.12 EFC40523.1 - 0.027 14.0 0.1 0.071 12.7 0.1 1.7 1 0 0 1 1 1 0 CD34/Podocalyxin family Pox_A14 PF05767.12 EFC40523.1 - 0.035 14.3 0.2 0.035 14.3 0.2 2.0 2 1 1 3 3 3 0 Poxvirus virion envelope protein A14 Sigma_reg_N PF13800.6 EFC40523.1 - 9.4 6.6 7.2 1.4 9.2 0.2 2.9 3 0 0 3 3 3 0 Sigma factor regulator N-terminal RabGAP-TBC PF00566.18 EFC40524.1 - 1.7e-46 158.6 1.6 1.7e-46 158.6 1.6 2.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain RGS PF00615.19 EFC40525.1 - 0.0011 19.2 5.5 0.0011 19.2 5.5 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain Claudin_2 PF13903.6 EFC40525.1 - 8.1 6.1 14.0 0.63 9.8 3.7 3.1 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Ras PF00071.22 EFC40526.1 - 4.1e-52 176.0 1.2 5.1e-52 175.7 1.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40526.1 - 6.8e-21 74.7 0.5 1.2e-20 74.0 0.0 1.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40526.1 - 3.1e-12 46.3 0.0 4.3e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC40526.1 - 1.1e-09 38.2 0.4 2e-09 37.2 0.4 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC40526.1 - 2.9e-05 24.1 0.5 6.8e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC40526.1 - 9.1e-05 22.4 0.3 0.00014 21.7 0.3 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EFC40526.1 - 0.0034 16.9 0.1 0.0056 16.2 0.1 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EFC40526.1 - 0.0046 17.0 0.1 0.0095 15.9 0.1 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TniB PF05621.11 EFC40526.1 - 0.036 13.5 0.3 0.51 9.7 0.1 2.5 1 1 1 2 2 2 0 Bacterial TniB protein p450 PF00067.22 EFC40527.1 - 8.7e-53 179.7 2.6 3.2e-29 102.0 1.1 3.0 2 1 0 2 2 2 2 Cytochrome P450 GAF PF01590.26 EFC40528.1 - 0.0017 19.0 0.0 0.0026 18.4 0.0 1.2 1 0 0 1 1 1 1 GAF domain Closter_coat PF01785.17 EFC40528.1 - 0.023 14.0 0.2 0.035 13.4 0.2 1.3 1 0 0 1 1 1 0 Closterovirus coat protein GAF_2 PF13185.6 EFC40528.1 - 0.032 14.5 0.0 0.053 13.8 0.0 1.4 1 0 0 1 1 1 0 GAF domain CENP-P PF13096.6 EFC40528.1 - 0.06 13.0 1.0 0.14 11.8 0.7 1.7 1 1 1 2 2 2 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P DUF3666 PF12408.8 EFC40528.1 - 0.072 12.3 0.0 2.7 7.3 0.0 2.4 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase Pkinase PF00069.25 EFC40529.1 - 7.1e-48 163.3 5.9 9.2e-48 162.9 0.8 3.5 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40529.1 - 9.1e-32 110.3 0.1 2.3e-31 109.0 0.1 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC40529.1 - 6.4e-08 33.1 0.2 0.011 16.3 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC40529.1 - 0.0018 18.8 0.0 9.2 7.0 0.0 4.5 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Kdo PF06293.14 EFC40529.1 - 0.015 14.6 0.0 0.047 13.1 0.0 1.8 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ArnB_C PF18677.1 EFC40529.1 - 0.024 14.7 0.3 6.8 6.9 0.0 3.3 2 0 0 2 2 2 0 Archaellum regulatory network B, C-terminal domain HutD PF05962.11 EFC40530.1 - 1e-16 61.5 0.1 4.9e-10 39.7 0.0 3.4 2 1 0 2 2 2 2 HutD PRMT5_C PF17286.2 EFC40530.1 - 0.013 15.4 0.4 0.02 14.8 0.4 1.4 1 0 0 1 1 1 0 PRMT5 oligomerisation domain TFIIA PF03153.13 EFC40530.1 - 0.072 13.1 5.9 0.11 12.5 5.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BB_PF PF18063.1 EFC40530.1 - 0.98 9.0 8.5 0.042 13.4 2.7 1.6 2 0 0 2 2 2 0 Beta barrel Pore-forming domain LRR_6 PF13516.6 EFC40531.1 - 6.6e-46 150.5 47.9 0.00046 20.0 0.1 17.2 17 0 0 17 17 17 14 Leucine Rich repeat LRR_8 PF13855.6 EFC40531.1 - 6.5e-37 125.1 43.7 4.8e-07 29.5 0.5 9.1 4 2 7 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 EFC40531.1 - 3e-34 116.5 50.4 1.9e-06 28.1 2.4 11.8 4 3 7 13 13 13 12 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC40531.1 - 2.5e-09 36.9 18.3 0.0056 16.2 0.4 4.8 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EFC40531.1 - 2.7e-08 33.2 38.1 16 6.5 0.1 13.8 13 3 1 14 14 14 2 Leucine Rich Repeat LRR_3 PF07725.12 EFC40531.1 - 0.077 12.9 0.2 6.6 6.8 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_5 PF13306.6 EFC40531.1 - 0.099 12.6 14.2 1.2 9.2 1.2 4.1 2 1 2 4 4 4 0 BspA type Leucine rich repeat region (6 copies) mTERF PF02536.14 EFC40532.1 - 0.0028 16.6 0.1 0.006 15.6 0.1 1.5 1 0 0 1 1 1 1 mTERF ADH_zinc_N PF00107.26 EFC40533.1 - 1.7e-19 70.1 0.0 3.5e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC40533.1 - 1.7e-14 55.0 0.0 2.9e-14 54.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC40533.1 - 8.5e-05 22.4 0.2 0.00055 19.8 0.0 2.2 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain PI3K_rbd PF00794.18 EFC40533.1 - 0.012 15.8 0.0 0.069 13.3 0.0 2.1 2 0 0 2 2 2 0 PI3-kinase family, ras-binding domain NHL PF01436.21 EFC40534.1 - 2.7e-10 39.7 6.3 0.064 13.3 0.1 5.5 5 0 0 5 5 5 3 NHL repeat SGL PF08450.12 EFC40534.1 - 0.00011 21.8 1.3 0.017 14.7 0.3 3.3 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Collagen PF01391.18 EFC40534.1 - 0.0039 16.9 30.2 0.0039 16.9 30.2 6.1 5 1 0 5 5 5 2 Collagen triple helix repeat (20 copies) Tnp_zf-ribbon_2 PF13842.6 EFC40534.1 - 0.0092 16.8 18.4 0.023 15.5 5.4 2.7 2 0 0 2 2 2 2 DDE_Tnp_1-like zinc-ribbon Arylesterase PF01731.20 EFC40534.1 - 0.029 14.6 0.0 4.3 7.6 0.0 3.5 3 1 1 4 4 4 0 Arylesterase FYVE PF01363.21 EFC40534.1 - 0.046 13.9 19.6 0.065 13.4 5.5 2.7 1 1 1 2 2 2 0 FYVE zinc finger zf-RRPl_C4 PF17026.5 EFC40534.1 - 8.7 6.5 15.7 15 5.7 2.8 2.8 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF3023 PF11224.8 EFC40535.1 - 0.0039 17.0 0.1 0.051 13.4 0.1 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF3023) FYVE PF01363.21 EFC40535.1 - 0.0044 17.1 9.3 0.0044 17.1 9.3 3.3 3 1 1 4 4 4 2 FYVE zinc finger NHL PF01436.21 EFC40535.1 - 0.01 15.8 0.5 0.097 12.8 0.2 2.7 2 0 0 2 2 2 0 NHL repeat Fucose_iso_N1 PF07881.12 EFC40535.1 - 0.036 13.9 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 L-fucose isomerase, first N-terminal domain FAD_binding_3 PF01494.19 EFC40536.1 - 1.5e-12 47.5 0.0 2.7e-10 40.1 0.0 2.4 1 1 1 2 2 2 2 FAD binding domain DAO PF01266.24 EFC40536.1 - 0.00012 21.8 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFC40536.1 - 0.0012 18.0 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.16 EFC40536.1 - 0.0019 17.8 0.3 0.0034 17.0 0.3 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_8 PF13450.6 EFC40536.1 - 0.0019 18.4 0.1 0.0053 16.9 0.0 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 EFC40536.1 - 0.0083 16.7 0.0 0.022 15.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFC40536.1 - 0.0092 15.4 0.1 0.025 13.9 0.1 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFC40536.1 - 0.034 13.4 0.0 0.058 12.6 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 EFC40536.1 - 0.067 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC40536.1 - 0.069 11.8 0.0 0.12 11.1 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 EFC40536.1 - 0.14 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EFC40536.1 - 0.15 11.1 0.1 0.28 10.2 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A UDPG_MGDP_dh_N PF03721.14 EFC40536.1 - 0.24 10.9 0.4 0.86 9.2 0.0 2.1 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Afi1 PF07792.12 EFC40537.1 - 8.1e-32 110.5 1.5 8.1e-32 110.5 1.5 2.9 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EFC40537.1 - 1.2e-29 102.5 0.2 3.8e-29 100.9 0.2 1.9 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EFC40537.1 - 2.1e-17 62.9 15.9 4.7e-07 28.8 8.5 4.8 2 1 1 3 3 3 3 Transport protein Avl9 DENN PF02141.21 EFC40537.1 - 0.2 11.6 2.6 1 9.3 0.4 3.1 3 1 0 3 3 3 0 DENN (AEX-3) domain sCache_like PF16736.5 EFC40537.1 - 2.1 8.5 8.8 0.54 10.4 0.2 4.0 4 0 0 4 4 4 0 Single Cache-like DNA_pol_B PF00136.21 EFC40538.1 - 1.9e-93 313.7 2.7 3.4e-93 312.9 2.7 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFC40538.1 - 4e-17 62.4 1.0 8.6e-09 35.0 0.5 3.3 2 1 0 2 2 2 2 DNA polymerase family B, exonuclease domain BAH PF01426.18 EFC40538.1 - 8.7e-15 54.7 3.6 2.5e-14 53.2 0.2 3.2 3 0 0 3 3 3 1 BAH domain zf-C4pol PF14260.6 EFC40538.1 - 6.6e-08 32.9 5.2 2.3e-07 31.2 5.2 2.1 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta His_Phos_2 PF00328.22 EFC40539.1 - 2e-17 63.7 0.0 6.1e-08 32.4 0.0 2.4 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) SLATT_fungal PF18142.1 EFC40539.1 - 0.0096 15.9 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain Peripla_BP_6 PF13458.6 EFC40540.1 - 3e-30 106.0 0.0 1.1e-13 51.6 0.0 5.0 4 1 0 4 4 4 3 Periplasmic binding protein Guanylate_cyc PF00211.20 EFC40540.1 - 1.8e-19 70.1 0.0 3.6e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 EFC40540.1 - 4.5e-09 35.9 3.6 1.3e-05 24.5 0.0 3.1 3 0 0 3 3 3 2 Receptor family ligand binding region RnlB_antitoxin PF15933.5 EFC40541.1 - 0.036 14.4 0.2 14 6.1 0.0 2.7 3 1 0 3 3 3 0 Antitoxin to bacterial toxin RNase LS or RnlA Ras PF00071.22 EFC40542.1 - 2.4e-15 56.5 0.1 4e-15 55.8 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40542.1 - 4.9e-09 36.5 0.0 1.1e-08 35.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase BPD_transp_1 PF00528.22 EFC40543.1 - 0.12 12.1 17.6 0.092 12.5 14.7 2.2 1 1 1 2 2 2 0 Binding-protein-dependent transport system inner membrane component CitMHS PF03600.16 EFC40543.1 - 2.6 7.1 9.7 3.8 6.6 9.7 1.2 1 0 0 1 1 1 0 Citrate transporter Orai-1 PF07856.12 EFC40543.1 - 6.5 6.4 14.4 3.8 7.2 11.9 1.9 1 1 1 2 2 2 0 Mediator of CRAC channel activity HSP70 PF00012.20 EFC40544.1 - 5.8e-50 170.1 0.1 7.8e-50 169.7 0.1 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC40544.1 - 0.00029 19.8 0.0 0.00064 18.6 0.0 1.5 1 1 1 2 2 2 1 MreB/Mbl protein PCI PF01399.27 EFC40544.1 - 0.0078 16.7 0.6 0.051 14.1 0.1 2.5 2 0 0 2 2 2 1 PCI domain Ras PF00071.22 EFC40545.1 - 7.4e-59 198.0 0.1 8.6e-59 197.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40545.1 - 4.6e-21 75.2 0.0 6.8e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40545.1 - 2.1e-10 40.3 0.0 2.3e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC40545.1 - 2.3e-06 27.3 0.1 5.7e-06 26.0 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC40545.1 - 3.6e-05 23.8 0.0 5.5e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC40545.1 - 0.00026 21.0 0.0 0.11 12.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EFC40545.1 - 0.0003 20.6 1.8 0.0045 16.8 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EFC40545.1 - 0.0052 16.3 0.4 0.015 14.8 0.4 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B G-alpha PF00503.20 EFC40545.1 - 0.014 14.6 0.1 0.36 9.9 0.0 2.2 1 1 0 2 2 2 0 G-protein alpha subunit SRPRB PF09439.10 EFC40545.1 - 0.027 13.9 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AMP-binding PF00501.28 EFC40546.1 - 2e-53 181.5 0.0 6.3e-53 179.9 0.0 1.8 2 1 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC40546.1 - 0.0054 17.7 0.1 0.015 16.3 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ABC_membrane PF00664.23 EFC40547.1 - 3.9e-40 138.2 16.3 5.9e-40 137.6 16.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC40547.1 - 2.1e-35 122.2 0.0 4.2e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC40547.1 - 4.2e-08 32.9 2.8 6.3e-06 25.8 0.2 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC40547.1 - 4.6e-05 23.9 0.3 0.00012 22.5 0.3 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC40547.1 - 0.00071 19.9 0.2 0.0031 17.8 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFC40547.1 - 0.00086 19.0 0.0 0.0025 17.5 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EFC40547.1 - 0.00097 18.9 0.1 0.0015 18.4 0.1 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EFC40547.1 - 0.0029 17.3 0.1 0.075 12.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFC40547.1 - 0.005 16.8 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 EFC40547.1 - 0.0053 16.6 0.1 0.26 11.1 0.0 2.3 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EFC40547.1 - 0.0055 16.7 0.0 0.2 11.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EFC40547.1 - 0.012 16.1 0.1 1.8 9.0 0.1 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFC40547.1 - 0.02 14.8 0.2 0.19 11.6 0.0 2.4 3 0 0 3 3 3 0 Rad17 P-loop domain SbcCD_C PF13558.6 EFC40547.1 - 0.027 14.7 0.2 0.21 11.8 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 EFC40547.1 - 0.034 14.3 2.4 1.8 8.6 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain DEAD PF00270.29 EFC40547.1 - 0.063 13.0 0.6 0.3 10.8 0.6 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_18 PF13238.6 EFC40547.1 - 0.065 13.8 0.0 0.2 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain Alpha-L-AF_C PF06964.12 EFC40547.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain APS_kinase PF01583.20 EFC40547.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.12 EFC40547.1 - 0.12 11.6 0.1 0.7 9.1 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 EFC40547.1 - 0.13 11.8 0.1 1.2 8.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain DYW_deaminase PF14432.6 EFC40548.1 - 2.1e-48 163.4 1.4 1.4e-47 160.7 0.4 2.5 2 0 0 2 2 2 1 DYW family of nucleic acid deaminases PPR_2 PF13041.6 EFC40548.1 - 1.5e-36 124.4 23.5 1.6e-07 31.4 0.0 13.1 10 1 4 14 14 14 6 PPR repeat family PPR PF01535.20 EFC40548.1 - 1.6e-33 112.6 31.3 0.00011 22.1 0.0 14.8 15 0 0 15 15 15 9 PPR repeat PPR_1 PF12854.7 EFC40548.1 - 7.8e-14 51.1 13.3 0.22 11.2 0.0 9.3 9 0 0 9 9 9 5 PPR repeat PPR_3 PF13812.6 EFC40548.1 - 1.2e-07 31.7 5.7 0.00062 19.8 0.0 7.0 8 1 1 9 9 9 1 Pentatricopeptide repeat domain TPR_14 PF13428.6 EFC40548.1 - 1.5e-06 28.5 0.0 24 6.1 0.0 6.7 8 0 0 8 8 6 0 Tetratricopeptide repeat DUF234 PF03008.14 EFC40548.1 - 0.0087 16.5 0.1 0.91 10.0 0.1 3.0 2 0 0 2 2 2 1 Archaea bacterial proteins of unknown function PPR_long PF17177.4 EFC40548.1 - 0.0095 15.3 0.2 0.3 10.4 0.0 3.2 3 1 1 4 4 4 2 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EFC40548.1 - 0.033 14.0 3.9 2.3 8.1 0.0 4.8 4 1 1 5 5 5 0 Mitochondrial ATPase expression TPR_7 PF13176.6 EFC40548.1 - 0.053 13.6 0.3 5.6 7.2 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat NUC205 PF08168.11 EFC40548.1 - 0.12 11.9 0.9 4.9 6.7 0.3 2.4 2 0 0 2 2 2 0 NUC205 domain TPR_17 PF13431.6 EFC40548.1 - 0.14 12.6 1.1 25 5.6 0.0 4.3 4 1 1 5 5 4 0 Tetratricopeptide repeat EGF_2 PF07974.13 EFC40549.1 - 0.0054 17.1 6.7 0.0054 17.1 6.7 7.5 7 1 0 7 7 7 4 EGF-like domain Trypan_PARP PF05887.11 EFC40550.1 - 5.9e-08 32.8 181.8 0.096 12.7 37.6 5.2 1 1 3 4 4 4 3 Procyclic acidic repetitive protein (PARP) EGF_2 PF07974.13 EFC40551.1 - 2e-36 124.0 200.2 1.9e-05 24.9 11.3 13.0 13 0 0 13 13 13 12 EGF-like domain REJ PF02010.15 EFC40551.1 - 2.1e-24 86.2 21.7 5.5e-21 74.9 10.5 3.0 3 0 0 3 3 3 2 REJ domain RRM_1 PF00076.22 EFC40552.1 - 1.1e-08 34.8 0.0 2.3e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OTU PF02338.19 EFC40552.1 - 1.1e-08 35.6 0.0 3.3e-08 34.1 0.0 1.8 1 0 0 1 1 1 1 OTU-like cysteine protease LAX PF15681.5 EFC40553.1 - 0.0057 15.5 0.7 0.0089 14.9 0.1 1.5 2 0 0 2 2 2 1 Lymphocyte activation family X START PF01852.19 EFC40554.1 - 6e-09 35.6 0.4 8.6e-09 35.1 0.4 1.3 1 0 0 1 1 1 1 START domain DUF4826 PF16108.5 EFC40554.1 - 0.033 14.4 0.1 0.078 13.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4826) Frataxin_Cyay PF01491.16 EFC40554.1 - 0.036 14.1 2.0 0.17 12.0 0.4 2.4 2 1 0 2 2 2 0 Frataxin-like domain Actin PF00022.19 EFC40555.1 - 7.8e-13 47.8 0.0 5.7e-07 28.5 0.0 2.3 2 0 0 2 2 2 2 Actin 2OG-FeII_Oxy_3 PF13640.6 EFC40555.1 - 3.3e-07 31.1 0.0 7.4e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EFC40555.1 - 0.0058 16.5 0.0 0.029 14.3 0.0 2.3 2 0 0 2 2 2 1 F-box-like RNase_H2_suC PF08615.11 EFC40555.1 - 0.055 13.6 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) RRF_GI PF12614.8 EFC40555.1 - 0.17 12.1 0.6 0.52 10.5 0.1 2.0 2 0 0 2 2 2 0 Ribosome recycling factor PARP PF00644.20 EFC40556.1 - 0.00017 21.3 1.9 0.00019 21.1 0.2 2.0 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain LRR_6 PF13516.6 EFC40557.1 - 1.4e-28 96.4 18.5 2.7e-05 23.9 0.1 9.1 10 0 0 10 10 10 6 Leucine Rich repeat LRR_8 PF13855.6 EFC40557.1 - 6.4e-26 89.9 44.2 3.8e-09 36.2 2.2 4.8 2 1 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC40557.1 - 6.9e-17 61.3 30.9 0.00012 22.4 0.1 6.6 4 2 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40557.1 - 3.2e-09 36.0 18.6 3.5 8.5 0.0 8.1 8 1 1 9 9 9 6 Leucine Rich Repeat LRR_9 PF14580.6 EFC40557.1 - 0.00014 21.4 15.8 0.01 15.3 2.7 3.2 2 2 1 3 3 3 2 Leucine-rich repeat F-box-like PF12937.7 EFC40557.1 - 0.0029 17.4 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like CCDC154 PF15450.6 EFC40558.1 - 0.25 9.8 1.1 0.38 9.3 1.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 154 Com_YlbF PF06133.11 EFC40558.1 - 1.2 9.8 6.3 2.3 8.9 3.1 2.6 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DUF5344 PF17279.2 EFC40558.1 - 3.2 8.4 10.4 14 6.4 0.2 3.9 3 1 2 5 5 5 0 Family of unknown function (DUF5344) G-alpha PF00503.20 EFC40559.1 - 4.8e-57 193.7 2.2 2.6e-41 142.0 0.5 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 EFC40559.1 - 1.2e-09 37.9 0.5 2.7e-06 27.0 0.1 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC40559.1 - 0.0014 18.7 0.5 2.4 8.3 0.0 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC40559.1 - 0.017 14.5 2.0 1.9 7.8 0.0 2.5 2 1 1 3 3 3 0 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC40559.1 - 0.022 15.0 0.1 0.61 10.3 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC40559.1 - 0.078 12.5 0.1 5.6 6.4 0.1 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC40559.1 - 0.083 12.3 1.0 2.7 7.4 0.2 2.5 2 1 1 3 3 3 0 Signal recognition particle receptor beta subunit CPT PF07931.12 EFC40559.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.9 EFC40559.1 - 0.16 11.7 0.3 0.42 10.4 0.1 1.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_S30 PF04758.14 EFC40560.1 - 3.1e-06 27.3 0.1 3.1e-06 27.3 0.1 2.4 2 1 0 2 2 2 1 Ribosomal protein S30 Sec62 PF03839.16 EFC40561.1 - 0.11 12.0 1.5 0.13 11.8 1.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 EFC40561.1 - 3.2 6.4 5.1 3.6 6.2 5.1 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_C39_2 PF13529.6 EFC40562.1 - 3.4e-08 34.2 0.1 9.3e-05 23.0 0.1 2.6 1 1 1 2 2 2 2 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFC40562.1 - 5.2e-07 29.8 0.0 0.00074 19.5 0.0 2.3 2 0 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.8 EFC40562.1 - 1.8e-05 24.3 0.0 3.4e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C39 PF03412.15 EFC40562.1 - 0.063 13.1 0.0 0.21 11.4 0.0 1.9 2 0 0 2 2 2 0 Peptidase C39 family Fascin PF06268.13 EFC40563.1 - 7.8e-06 26.1 0.0 0.0082 16.4 0.0 2.4 2 0 0 2 2 2 2 Fascin domain FRG1 PF06229.12 EFC40563.1 - 0.00049 19.9 0.0 0.11 12.2 0.0 2.3 1 1 1 2 2 2 2 FRG1-like domain EF-hand_6 PF13405.6 EFC40563.1 - 0.0067 16.3 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 EFC40563.1 - 0.014 14.9 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EFC40563.1 - 0.12 12.8 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair Pentapeptide PF00805.22 EFC40564.1 - 5e-22 77.2 29.3 1.6e-11 43.6 6.6 5.0 4 1 0 4 4 4 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC40564.1 - 1.4e-21 76.4 29.9 3.1e-08 33.7 0.9 4.6 1 1 3 4 4 4 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC40564.1 - 4e-16 58.9 26.8 2e-05 24.6 3.1 4.2 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) zf-RING_6 PF14835.6 EFC40564.1 - 1.7e-06 27.8 6.4 8.1e-06 25.6 6.4 2.2 1 0 0 1 1 1 1 zf-RING of BARD1-type protein BTB_2 PF02214.22 EFC40564.1 - 0.00044 20.5 0.0 0.0012 19.2 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain zf-RING_5 PF14634.6 EFC40564.1 - 0.0013 18.7 9.9 0.0013 18.7 9.9 2.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFC40564.1 - 0.0019 18.0 7.7 0.0019 18.0 7.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Tox-ODYAM1 PF15642.6 EFC40564.1 - 0.0048 15.9 3.9 0.0075 15.3 3.9 1.2 1 0 0 1 1 1 1 Toxin in Odyssella and Amoebophilus DUF3342 PF11822.8 EFC40564.1 - 0.0058 16.8 0.1 0.12 12.6 0.0 2.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3342) zf-C3HC4_2 PF13923.6 EFC40564.1 - 0.007 16.2 12.0 0.007 16.2 12.0 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) BTB PF00651.31 EFC40564.1 - 0.0085 16.3 0.0 0.031 14.5 0.0 2.0 1 1 0 1 1 1 1 BTB/POZ domain zf-RING_2 PF13639.6 EFC40564.1 - 0.011 16.1 10.9 0.011 16.1 10.9 2.7 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 EFC40564.1 - 0.011 15.5 9.1 0.086 12.7 9.1 2.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFC40564.1 - 0.019 14.8 12.3 0.019 14.8 12.3 2.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) OmpH PF03938.14 EFC40564.1 - 0.032 14.6 3.7 0.052 13.9 3.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1272 PF06906.11 EFC40564.1 - 0.058 13.5 11.5 0.037 14.1 5.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-TRAF PF02176.18 EFC40564.1 - 0.078 13.7 0.3 0.078 13.7 0.3 4.3 6 0 0 6 6 3 0 TRAF-type zinc finger Apolipoprotein PF01442.18 EFC40564.1 - 0.085 12.7 4.9 0.13 12.2 4.9 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DASH_Spc34 PF08657.10 EFC40564.1 - 0.18 11.5 5.1 0.35 10.6 5.1 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 DUF1664 PF07889.12 EFC40564.1 - 0.2 11.7 2.0 0.26 11.3 0.8 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF1664) Mitofilin PF09731.9 EFC40564.1 - 5 5.8 10.4 8.1 5.1 10.4 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein zf-RING_UBOX PF13445.6 EFC40564.1 - 7.6 6.7 12.5 1.5 8.9 6.3 2.7 1 1 1 2 2 2 0 RING-type zinc-finger GST_C_3 PF14497.6 EFC40565.1 - 3.2e-18 65.7 0.1 5.2e-18 65.1 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC40565.1 - 1.9e-07 31.3 0.0 3.7e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC40565.1 - 3.1e-05 24.1 0.1 4.8e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC40565.1 - 0.085 13.3 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain CTNNBL PF08216.11 EFC40565.1 - 0.088 13.0 0.0 12 6.2 0.0 2.4 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Tom37 PF10568.9 EFC40565.1 - 0.094 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EFC40565.1 - 0.16 12.7 0.0 0.35 11.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Imm53 PF15580.6 EFC40566.1 - 0.11 12.2 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 53 Atthog PF18800.1 EFC40566.1 - 0.13 12.1 0.1 0.13 12.1 0.1 2.0 2 0 0 2 2 2 0 Attenuator of Hedgehog CrgA PF06781.12 EFC40566.1 - 0.2 11.7 0.6 0.6 10.2 0.0 2.1 2 0 0 2 2 2 0 Cell division protein CrgA HemY_N PF07219.13 EFC40566.1 - 2.7 8.2 5.0 3.8 7.7 0.6 2.2 2 0 0 2 2 2 0 HemY protein N-terminus Svf1 PF08622.10 EFC40567.1 - 0.034 14.2 0.7 0.073 13.1 0.7 1.5 1 0 0 1 1 1 0 Svf1-like N-terminal lipocalin domain Amnionless PF14828.6 EFC40568.1 - 0.0012 17.8 0.1 0.0014 17.6 0.1 1.1 1 0 0 1 1 1 1 Amnionless DUF5518 PF17647.1 EFC40568.1 - 0.0087 16.2 2.3 0.0087 16.2 2.3 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF5518) DUF2207 PF09972.9 EFC40568.1 - 0.012 14.4 0.0 0.015 14.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PTP_tm PF18861.1 EFC40568.1 - 0.015 15.3 1.8 0.031 14.3 1.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J SPG4 PF17325.2 EFC40568.1 - 0.84 10.8 5.7 0.25 12.4 0.5 2.0 2 0 0 2 2 2 0 Stationary phase protein 4 Stevor PF17410.2 EFC40568.1 - 1.8 8.1 6.5 0.5 9.9 0.2 2.2 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame DUF4834 PF16118.5 EFC40568.1 - 3.1 8.8 9.0 0.68 10.9 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) APH PF01636.23 EFC40569.1 - 1.5e-09 38.1 0.0 1.6e-09 38.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFC40569.1 - 5.5e-08 32.5 1.0 5.7e-08 32.4 1.0 1.0 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EFC40569.1 - 4.4e-05 22.5 0.2 4.8e-05 22.4 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Haspin_kinase PF12330.8 EFC40569.1 - 4.9e-05 22.4 0.0 5.7e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EFC40569.1 - 0.00081 19.0 1.5 0.00085 19.0 1.5 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Laterosporulin PF17861.1 EFC40569.1 - 0.05 14.0 0.7 0.11 13.0 0.1 1.9 1 1 1 2 2 2 0 Laterosporulin defensin-like peptide Pkinase PF00069.25 EFC40569.1 - 0.052 12.9 0.4 0.069 12.5 0.4 1.5 1 1 0 1 1 1 0 Protein kinase domain APH_6_hur PF04655.14 EFC40569.1 - 0.074 12.4 0.0 0.083 12.3 0.0 1.1 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase Yip1 PF04893.17 EFC40570.1 - 5.7e-05 22.9 21.2 8.7e-05 22.3 6.9 2.7 2 1 0 2 2 2 2 Yip1 domain TspO_MBR PF03073.15 EFC40570.1 - 0.051 13.6 9.3 0.18 11.9 9.3 1.9 1 1 0 1 1 1 0 TspO/MBR family UPF0139 PF03669.13 EFC40570.1 - 0.44 10.4 1.9 4 7.4 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) PRP1_N PF06424.12 EFC40571.1 - 6.8 7.1 10.4 16 5.9 10.4 1.6 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal adh_short PF00106.25 EFC40572.1 - 9.7e-20 70.8 0.0 1e-13 51.2 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC40572.1 - 1.1e-14 54.6 0.0 1.4e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC40572.1 - 0.0068 16.3 0.0 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 EFC40572.1 - 0.069 12.6 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EFC40572.1 - 0.078 12.3 0.0 0.22 10.8 0.0 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TetR_C_5 PF08360.11 EFC40573.1 - 0.039 14.2 1.2 0.061 13.5 1.2 1.3 1 0 0 1 1 1 0 QacR-like protein, C-terminal region DUF2672 PF10878.8 EFC40575.1 - 0.087 12.8 0.4 2 8.4 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2672) DUF2937 PF11157.8 EFC40575.1 - 0.19 11.5 0.8 0.4 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) SBF2 PF12335.8 EFC40575.1 - 6.4 6.3 19.6 0.012 15.3 1.8 3.6 2 2 0 2 2 2 0 Myotubularin protein Tetraspanin PF00335.20 EFC40576.1 - 0.24 11.1 13.3 0.57 9.9 9.3 2.1 1 1 1 2 2 2 0 Tetraspanin family DUF1422 PF07226.11 EFC40576.1 - 0.77 9.8 12.2 3.5 7.7 3.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1422) DUF4229 PF14012.6 EFC40576.1 - 3.5 7.8 8.2 0.52 10.5 3.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4229) DUF588 PF04535.12 EFC40576.1 - 5.9 6.7 13.0 1.3e+03 -1.0 13.0 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF588) Erf4 PF10256.9 EFC40577.1 - 0.019 15.1 0.3 0.028 14.5 0.3 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Pkinase_Tyr PF07714.17 EFC40578.1 - 1.1e-48 165.8 0.2 5e-47 160.3 0.2 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC40578.1 - 8.1e-46 156.5 0.2 8.5e-45 153.2 0.2 2.4 1 1 0 1 1 1 1 Protein kinase domain DUF2149 PF09919.9 EFC40578.1 - 0.075 13.3 0.2 0.3 11.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) Pkinase PF00069.25 EFC40579.1 - 7.8e-33 113.9 2.9 5.7e-24 84.9 0.3 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40579.1 - 4.8e-25 88.3 0.6 2e-16 60.1 0.4 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase IQ PF00612.27 EFC40579.1 - 0.001 18.7 0.3 0.0026 17.4 0.3 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Not3 PF04065.15 EFC40579.1 - 0.0031 17.0 0.7 0.0078 15.7 0.7 1.7 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component ComZ PF10815.8 EFC40582.1 - 0.084 12.9 0.2 0.55 10.3 0.0 2.1 2 0 0 2 2 2 0 ComZ Folliculin PF11704.8 EFC40582.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport LRR_4 PF12799.7 EFC40583.1 - 0.00011 22.5 2.8 0.00011 22.5 2.8 7.7 5 3 3 8 8 8 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC40583.1 - 0.00034 20.4 0.0 0.0014 18.5 0.0 2.1 1 0 0 1 1 1 1 F-box-like TFIIA_gamma_C PF02751.14 EFC40583.1 - 0.052 13.7 0.2 0.9 9.7 0.2 2.9 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit SF-assemblin PF06705.11 EFC40585.1 - 2.8e-33 115.3 28.6 2.8e-33 115.3 28.6 1.5 1 1 1 2 2 2 1 SF-assemblin/beta giardin DUF1525 PF07511.11 EFC40585.1 - 0.2 11.8 4.1 1.5 9.0 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) DUF4407 PF14362.6 EFC40585.1 - 0.24 10.7 10.5 0.97 8.7 10.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Lzipper-MIP1 PF14389.6 EFC40585.1 - 1.2 9.5 14.3 0.15 12.3 2.7 3.8 1 1 3 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Abhydrolase_3 PF07859.13 EFC40586.1 - 2.5e-11 43.8 1.2 5.4e-10 39.5 1.2 2.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC40586.1 - 5.2e-07 28.8 1.2 9.4e-07 28.0 1.2 1.3 1 1 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 EFC40586.1 - 5.7e-05 22.2 0.4 0.00081 18.4 0.4 2.2 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 EFC40586.1 - 0.0018 17.8 0.0 0.0044 16.5 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EFC40586.1 - 0.0026 17.6 0.3 0.021 14.6 0.3 2.1 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 EFC40586.1 - 0.013 16.2 0.0 0.015 16.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF226 PF02890.14 EFC40586.1 - 0.014 15.5 0.1 0.63 10.1 0.1 2.6 2 0 0 2 2 2 0 Borrelia family of unknown function DUF226 DUF3089 PF11288.8 EFC40586.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) RGS PF00615.19 EFC40588.1 - 2.6e-16 60.0 3.9 2.6e-16 60.0 3.9 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC40588.1 - 0.01 15.6 0.3 0.022 14.5 0.2 1.6 1 1 0 1 1 1 0 Regulator of G protein signalling-like domain Iso_dh PF00180.20 EFC40589.1 - 1e-58 199.2 0.0 1.2e-58 199.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF2362 PF10154.9 EFC40590.1 - 1.7e-17 63.6 28.3 2.4e-11 43.3 0.6 4.3 3 1 0 3 3 3 3 Uncharacterized conserved protein (DUF2362) Macro PF01661.21 EFC40590.1 - 0.0047 16.9 0.0 0.017 15.1 0.0 1.9 1 0 0 1 1 1 1 Macro domain ABC_membrane PF00664.23 EFC40591.1 - 2.4e-53 181.6 17.1 3.4e-53 181.1 17.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC40591.1 - 4.4e-33 114.7 0.0 1.3e-32 113.1 0.0 1.9 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EFC40591.1 - 3.7e-08 33.1 0.0 2.9e-05 23.6 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC40591.1 - 3e-05 24.5 0.0 0.0003 21.2 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFC40591.1 - 0.00077 19.2 0.1 0.0018 18.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC40591.1 - 0.0015 18.3 0.0 0.01 15.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EFC40591.1 - 0.0056 17.1 0.1 0.16 12.4 0.1 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC40591.1 - 0.0064 16.8 0.1 0.041 14.2 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFC40591.1 - 0.027 14.5 0.0 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.9 EFC40591.1 - 0.035 12.9 0.0 0.063 12.1 0.0 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_15 PF13175.6 EFC40591.1 - 0.058 13.1 0.1 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFC40591.1 - 0.064 13.2 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 EFC40591.1 - 0.11 12.3 0.1 2.5 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFC40591.1 - 0.16 12.5 0.0 1.1 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Peptidase_M42 PF05343.14 EFC40592.1 - 1e-07 31.3 0.0 3.2e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 EFC40592.1 - 0.0072 16.0 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF2605 PF10792.9 EFC40592.1 - 0.11 12.5 0.0 0.36 10.8 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2605) Ank_2 PF12796.7 EFC40593.1 - 4.2e-30 104.2 3.4 1.6e-12 47.9 0.0 3.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC40593.1 - 2.9e-24 82.5 3.5 0.0059 17.0 0.0 7.1 6 1 1 7 7 7 5 Ankyrin repeat Ank_4 PF13637.6 EFC40593.1 - 6.4e-20 71.2 1.8 2e-05 25.0 0.0 5.3 2 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC40593.1 - 4.7e-14 52.1 0.8 0.066 13.7 0.0 5.7 4 1 1 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFC40593.1 - 2.9e-08 33.8 0.5 0.083 13.2 0.1 4.6 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Shigella_OspC PF06128.11 EFC40593.1 - 0.0082 15.9 0.1 2.5 7.7 0.2 3.1 2 1 0 2 2 2 1 Shigella flexneri OspC protein PRK PF00485.18 EFC40594.1 - 8.7e-58 195.3 0.2 1.4e-57 194.6 0.2 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 EFC40594.1 - 7.2e-09 36.3 0.1 1.5e-08 35.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EFC40594.1 - 3.2e-06 26.6 0.0 5.8e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 EFC40594.1 - 8.3e-06 26.0 0.0 1.8e-05 24.9 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.6 EFC40594.1 - 9e-06 26.2 1.3 6.9e-05 23.3 1.3 2.1 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 EFC40594.1 - 1.1e-05 25.1 0.0 0.0098 15.6 0.0 2.3 2 0 0 2 2 2 2 Dephospho-CoA kinase Cytidylate_kin PF02224.18 EFC40594.1 - 0.00015 21.6 0.1 0.15 11.8 0.0 2.5 3 0 0 3 3 3 2 Cytidylate kinase AAA_16 PF13191.6 EFC40594.1 - 0.00059 20.3 0.0 0.00091 19.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 EFC40594.1 - 0.014 15.4 0.2 0.026 14.5 0.1 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Thymidylate_kin PF02223.17 EFC40594.1 - 0.022 14.5 0.1 3.1 7.4 0.0 2.4 2 0 0 2 2 2 0 Thymidylate kinase CbiA PF01656.23 EFC40594.1 - 0.026 14.6 0.0 0.052 13.6 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EFC40594.1 - 0.029 14.6 0.0 0.051 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 EFC40594.1 - 0.039 13.9 0.1 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.10 EFC40594.1 - 0.047 13.1 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_14 PF13173.6 EFC40594.1 - 0.061 13.4 0.0 0.15 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFC40594.1 - 0.066 13.0 0.1 0.23 11.2 0.1 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein APS_kinase PF01583.20 EFC40594.1 - 0.066 13.1 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_28 PF13521.6 EFC40594.1 - 0.066 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFC40594.1 - 0.088 11.8 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein CPT PF07931.12 EFC40594.1 - 0.095 12.5 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Fumble PF03630.14 EFC40595.1 - 1.9e-130 434.9 0.8 3e-130 434.2 0.8 1.3 1 0 0 1 1 1 1 Fumble TFIID-18kDa PF02269.16 EFC40596.1 - 3.7e-08 33.3 0.5 1.8e-07 31.1 0.1 2.2 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Activator_LAG-3 PF11498.8 EFC40596.1 - 1 8.3 7.7 0.74 8.7 5.7 1.7 2 0 0 2 2 2 0 Transcriptional activator LAG-3 EGF_2 PF07974.13 EFC40597.1 - 0.00014 22.1 7.0 0.00014 22.1 7.0 10.6 10 3 0 10 10 10 1 EGF-like domain CHCH PF06747.13 EFC40597.1 - 4.3 7.6 11.9 2.1 8.6 0.6 4.2 3 0 0 3 3 3 0 CHCH domain DUF4116 PF13475.6 EFC40598.1 - 4.8e-18 64.6 7.0 1.9e-10 40.3 0.1 3.8 2 1 1 3 3 3 3 Domain of unknown function (DUF4116) LAGLIDADG_WhiA PF14527.6 EFC40598.1 - 0.072 13.2 1.5 0.21 11.7 0.7 2.1 1 1 1 2 2 2 0 WhiA LAGLIDADG-like domain Ank_2 PF12796.7 EFC40599.1 - 1.4e-15 57.6 0.1 0.00013 22.5 0.0 3.6 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC40599.1 - 6e-11 41.6 1.9 0.18 12.4 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFC40599.1 - 5.8e-07 29.9 0.1 1.7 9.3 0.0 4.6 2 2 4 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC40599.1 - 5.6e-06 26.6 0.6 17 6.1 0.0 5.9 6 0 0 6 6 6 1 Ankyrin repeat HopW1-1 PF15457.6 EFC40599.1 - 0.016 14.5 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Type III T3SS secreted effector HopW1-1/HopPmaA ATP-gua_PtransN PF02807.15 EFC40599.1 - 0.048 14.1 0.0 0.52 10.8 0.0 2.7 3 0 0 3 3 3 0 ATP:guanido phosphotransferase, N-terminal domain E_Pc_C PF06752.12 EFC40599.1 - 0.43 10.7 4.3 0.64 10.1 4.3 1.2 1 0 0 1 1 1 0 Enhancer of Polycomb C-terminus TMEM171 PF15471.6 EFC40600.1 - 1.5 7.7 6.3 0.19 10.7 1.8 1.7 1 1 1 2 2 2 0 Transmembrane protein family 171 LMBR1 PF04791.16 EFC40601.1 - 6e-61 206.9 22.9 9.2e-61 206.3 22.9 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF1682 PF07946.14 EFC40602.1 - 3e-23 82.6 4.1 3e-23 82.6 4.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1682) DUF4038 PF13204.6 EFC40602.1 - 0.033 13.8 2.1 0.056 13.1 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4038) Presenilin PF01080.17 EFC40602.1 - 2.6 6.7 10.4 0.12 11.1 0.5 2.2 2 0 0 2 2 2 0 Presenilin RNB PF00773.19 EFC40603.1 - 9.5e-37 127.0 0.3 9.5e-37 127.0 0.3 3.1 4 2 2 6 6 6 1 RNB domain DUF4625 PF15418.6 EFC40605.1 - 0.35 11.1 3.9 0.13 12.5 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) E2F_TDP PF02319.20 EFC40606.1 - 1.5e-29 101.9 3.7 3.2e-17 62.3 0.1 2.4 2 0 0 2 2 2 2 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 EFC40606.1 - 0.016 15.0 0.2 0.36 10.7 0.0 2.6 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF5572 PF17733.1 EFC40606.1 - 0.055 13.3 0.5 0.47 10.3 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5572) EMC3_TMCO1 PF01956.16 EFC40608.1 - 0.016 15.0 0.8 0.018 14.8 0.8 1.2 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like WD40 PF00400.32 EFC40609.1 - 1.4e-40 136.5 21.3 2.6e-08 34.4 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC40609.1 - 1.6e-13 50.7 1.1 0.45 10.8 0.0 5.7 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC40609.1 - 5.4e-06 25.6 0.3 0.042 12.8 0.2 3.0 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EFC40609.1 - 0.0036 15.9 0.0 0.0055 15.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain B_lectin PF01453.24 EFC40609.1 - 0.068 13.7 0.1 22 5.7 0.0 3.0 2 1 0 2 2 2 0 D-mannose binding lectin TPR_2 PF07719.17 EFC40610.1 - 7e-31 103.8 15.8 0.00086 19.2 0.1 9.6 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40610.1 - 4.3e-28 95.9 15.6 5e-06 26.1 0.1 8.5 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40610.1 - 4.9e-22 76.3 8.6 0.00016 21.6 0.0 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40610.1 - 3.1e-19 69.0 10.5 0.00067 19.9 0.0 7.0 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40610.1 - 3e-17 61.8 0.9 0.26 12.2 0.0 8.3 5 2 4 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40610.1 - 9.3e-16 58.1 2.1 0.00079 19.9 0.0 6.0 4 1 2 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40610.1 - 4.3e-14 51.4 5.1 0.0003 20.6 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC40610.1 - 2.8e-13 50.2 0.0 0.43 11.3 0.0 6.3 5 1 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40610.1 - 2.5e-12 46.3 2.2 0.12 12.1 0.0 6.5 6 0 0 6 6 6 3 TPR repeat TPR_6 PF13174.6 EFC40610.1 - 1.6e-10 40.9 8.2 0.043 14.5 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40610.1 - 1.9e-09 37.2 11.1 0.67 10.5 0.0 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC40610.1 - 6.4e-08 32.7 12.3 0.00073 19.7 0.7 4.9 3 1 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFC40610.1 - 1.1e-07 31.9 0.1 0.38 10.9 0.0 5.1 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC40610.1 - 8.2e-07 28.7 8.9 0.11 12.4 0.1 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EFC40610.1 - 0.0059 15.7 0.0 0.0091 15.1 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region ChAPs PF09295.10 EFC40610.1 - 0.031 13.3 0.1 0.11 11.5 0.0 1.9 1 1 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.9 EFC40610.1 - 0.049 13.3 1.5 8.2 6.1 0.1 3.6 1 1 2 3 3 3 0 26S proteasome subunit RPN7 AAA_2 PF07724.14 EFC40612.1 - 5.1e-43 147.1 1.0 4.9e-35 121.1 0.1 3.0 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFC40612.1 - 1e-12 48.6 3.5 8.2e-06 26.3 0.0 3.2 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 EFC40612.1 - 7e-07 28.6 0.5 3.7e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain AAA_5 PF07728.14 EFC40612.1 - 7.1e-07 29.3 1.7 0.00013 22.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 EFC40612.1 - 6.7e-05 22.9 0.0 0.0002 21.3 0.0 1.9 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 EFC40612.1 - 0.00016 22.1 0.5 0.00065 20.1 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFC40612.1 - 0.0002 21.7 1.8 0.0092 16.3 0.1 3.4 3 1 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 EFC40612.1 - 0.00028 20.3 0.1 0.0052 16.2 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI G-alpha PF00503.20 EFC40612.1 - 0.00057 19.1 0.1 0.0025 17.0 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit AAA_18 PF13238.6 EFC40612.1 - 0.00099 19.7 0.4 0.0035 17.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFC40612.1 - 0.0018 17.5 0.1 0.0048 16.2 0.1 1.8 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 EFC40612.1 - 0.0026 17.5 0.1 0.37 10.5 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 EFC40612.1 - 0.003 17.3 0.0 0.044 13.5 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 EFC40612.1 - 0.0087 16.2 0.0 0.026 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFC40612.1 - 0.029 14.6 0.0 0.078 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFC40612.1 - 0.047 13.4 1.8 0.062 13.0 0.0 2.2 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EFC40612.1 - 0.05 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 EFC40612.1 - 0.052 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFC40612.1 - 0.053 12.9 0.1 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 EFC40612.1 - 0.057 13.2 0.0 0.22 11.3 0.0 2.0 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATP-synt_ab PF00006.25 EFC40612.1 - 0.13 11.9 0.3 0.41 10.3 0.0 1.9 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Tubulin PF00091.25 EFC40613.1 - 2.7e-48 164.8 0.3 2.5e-47 161.6 0.1 2.1 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC40613.1 - 3.8e-27 95.0 0.0 7.6e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC40613.1 - 9.1e-06 25.5 0.0 1.7e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain SWIB PF02201.18 EFC40613.1 - 0.083 12.8 0.3 0.52 10.2 0.0 2.3 2 0 0 2 2 2 0 SWIB/MDM2 domain MTP18 PF10558.9 EFC40614.1 - 1.1e-24 87.4 0.0 1.5e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) MORN PF02493.20 EFC40615.1 - 6.2e-08 32.1 0.3 0.00029 20.5 0.1 2.5 2 0 0 2 2 2 2 MORN repeat DUF4926 PF16277.5 EFC40615.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4926) MORN PF02493.20 EFC40616.1 - 1.5e-17 62.3 25.3 7e-05 22.5 0.7 5.4 5 0 0 5 5 5 5 MORN repeat Type2_restr_D3 PF16902.5 EFC40616.1 - 0.32 10.9 3.8 0.93 9.5 0.1 2.8 3 0 0 3 3 3 0 Type-2 restriction enzyme D3 domain Form_Nir_trans PF01226.17 EFC40617.1 - 1e-36 126.5 28.1 1.2e-25 90.3 17.3 2.1 2 0 0 2 2 2 2 Formate/nitrite transporter Form_Nir_trans PF01226.17 EFC40618.1 - 7.8e-24 84.3 15.9 1.1e-23 83.8 15.9 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Sel1 PF08238.12 EFC40619.1 - 1.3e-13 51.1 8.1 1e-06 29.2 0.7 3.7 4 0 0 4 4 4 3 Sel1 repeat TPR_2 PF07719.17 EFC40619.1 - 1.5e-06 27.9 3.1 0.28 11.4 0.1 4.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40619.1 - 2.1e-05 24.2 1.2 0.96 9.6 0.0 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40619.1 - 3.7e-05 23.4 14.3 0.45 10.4 0.0 4.9 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40619.1 - 6.4e-05 22.8 14.7 0.0077 16.4 0.6 4.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40619.1 - 9.4e-05 22.0 5.3 0.16 11.6 0.1 3.7 3 0 0 3 3 3 2 TPR repeat RGS PF00615.19 EFC40619.1 - 0.011 16.0 1.5 0.029 14.6 1.5 1.6 1 0 0 1 1 1 0 Regulator of G protein signaling domain Speriolin_C PF15059.6 EFC40619.1 - 0.046 13.9 1.1 0.065 13.4 1.1 1.3 1 0 0 1 1 1 0 Speriolin C-terminus MIT PF04212.18 EFC40619.1 - 0.15 12.2 4.5 7.3 6.7 0.1 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain SBP_bac_3 PF00497.20 EFC40620.1 - 1e-15 57.8 0.0 1.4e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 EFC40620.1 - 0.1 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Ligated ion channel L-glutamate- and glycine-binding site Hydrolase_4 PF12146.8 EFC40622.1 - 2.3e-12 46.7 0.0 3.3e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC40622.1 - 9.9e-09 35.2 0.1 2.1e-05 24.3 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 EFC40622.1 - 2.7e-05 23.8 0.1 0.0037 16.8 0.0 2.2 1 1 0 2 2 2 1 Dienelactone hydrolase family Esterase PF00756.20 EFC40622.1 - 0.00033 20.4 0.0 0.00065 19.4 0.0 1.5 2 0 0 2 2 2 1 Putative esterase Abhydrolase_2 PF02230.16 EFC40622.1 - 0.0005 19.9 0.0 0.0046 16.8 0.0 2.3 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 EFC40622.1 - 0.00051 20.0 0.1 0.0028 17.6 0.1 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 EFC40622.1 - 0.0024 18.5 0.0 0.0037 17.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EFC40622.1 - 0.0085 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Ribosomal_S3Ae PF01015.18 EFC40622.1 - 0.033 13.8 0.1 0.06 12.9 0.1 1.3 1 0 0 1 1 1 0 Ribosomal S3Ae family Guanylate_cyc PF00211.20 EFC40623.1 - 1.2e-07 31.5 0.2 2.8e-07 30.3 0.2 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AAA_19 PF13245.6 EFC40623.1 - 0.22 11.9 0.4 2.7 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain DJ-1_PfpI PF01965.24 EFC40624.1 - 2.2e-26 92.6 0.0 2.6e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 EFC40624.1 - 5.8e-07 29.3 0.1 3.7e-06 26.7 0.1 2.0 1 1 0 1 1 1 1 C-terminal domain found in long catalases DUF4116 PF13475.6 EFC40625.1 - 7.8e-45 150.4 24.9 1.1e-10 41.1 0.2 8.4 4 2 6 10 10 10 10 Domain of unknown function (DUF4116) PARP PF00644.20 EFC40626.1 - 1.1e-12 48.0 1.0 2.1e-12 47.0 0.5 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFC40626.1 - 9.2e-05 22.6 2.2 0.00026 21.1 2.2 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFC40626.1 - 0.00043 20.3 0.9 0.0045 17.0 0.3 2.8 2 1 0 2 2 2 1 WGR domain VWA PF00092.28 EFC40627.1 - 2.4e-09 37.7 0.3 4.9e-09 36.7 0.3 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC40627.1 - 1.2e-08 35.5 0.2 3.5e-08 34.1 0.1 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF1160 PF06648.11 EFC40627.1 - 0.85 9.6 4.0 0.36 10.8 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1160) EGF_2 PF07974.13 EFC40629.1 - 2.3e-228 738.0 1646.1 5.8e-05 23.4 7.9 104.9 104 0 0 104 104 104 103 EGF-like domain DUF3494 PF11999.8 EFC40629.1 - 0.014 15.0 8.4 0.016 14.9 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3494) DUF1635 PF07795.11 EFC40630.1 - 0.76 9.6 5.1 0.25 11.2 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) BicD PF09730.9 EFC40631.1 - 0.066 11.6 0.0 0.085 11.3 0.0 1.2 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D RGS PF00615.19 EFC40632.1 - 1.2e-07 32.0 0.8 3.5e-07 30.5 0.8 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain Annexin PF00191.20 EFC40632.1 - 0.11 12.5 0.1 14 5.9 0.0 2.4 1 1 1 2 2 2 0 Annexin DUF2784 PF10861.8 EFC40633.1 - 0.029 14.4 3.5 0.081 13.0 3.5 1.7 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) ABC2_membrane_5 PF13346.6 EFC40633.1 - 2.5 7.6 15.7 0.18 11.3 6.0 2.2 1 1 2 3 3 3 0 ABC-2 family transporter protein RGS PF00615.19 EFC40634.1 - 2.7e-07 30.9 0.6 8.6e-07 29.2 0.6 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Metallophos PF00149.28 EFC40635.1 - 7.5e-12 46.2 6.5 1.2e-11 45.6 6.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC40635.1 - 2e-08 34.6 2.0 7.6e-08 32.7 2.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Imm7 PF15585.6 EFC40635.1 - 0.045 14.1 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 7 ATG16 PF08614.11 EFC40636.1 - 0.0008 19.7 10.9 0.0015 18.8 10.9 1.4 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Zn-C2H2_12 PF18112.1 EFC40636.1 - 0.0076 16.7 0.1 0.049 14.1 0.0 2.6 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain TcdA_TcdB PF12919.7 EFC40636.1 - 0.065 12.5 5.7 0.094 12.0 5.7 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain FTA4 PF13093.6 EFC40636.1 - 0.12 12.3 9.9 0.17 11.7 9.9 1.2 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Wtap PF17098.5 EFC40636.1 - 0.12 12.2 12.0 0.22 11.4 12.0 1.3 1 0 0 1 1 1 0 WTAP/Mum2p family UPF0242 PF06785.11 EFC40636.1 - 0.16 12.1 9.7 0.27 11.3 9.7 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3573 PF12097.8 EFC40636.1 - 0.31 9.8 6.2 0.62 8.8 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF3450 PF11932.8 EFC40636.1 - 3.5 6.8 15.1 8.9 5.5 12.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Halogen_Hydrol PF10112.9 EFC40636.1 - 8.2 6.4 9.1 1.5 8.8 0.4 2.3 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Profilin PF00235.19 EFC40637.1 - 1.4e-24 86.8 0.0 1.6e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Profilin DUF918 PF06033.11 EFC40638.1 - 0.083 12.9 0.5 0.7 9.9 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF918) Deltameth_res PF16020.5 EFC40638.1 - 0.15 12.0 0.5 1.9 8.4 0.1 2.7 3 0 0 3 3 3 0 Deltamethrin resistance AAA_11 PF13086.6 EFC40638.1 - 0.34 10.6 3.8 11 5.7 1.0 2.2 2 0 0 2 2 2 0 AAA domain RGS PF00615.19 EFC40639.1 - 0.00052 20.3 2.3 0.01 16.1 0.1 2.6 2 1 0 2 2 2 2 Regulator of G protein signaling domain CAF1-p150_N PF15557.6 EFC40639.1 - 2.5 8.0 8.4 12 5.8 7.0 2.5 2 1 0 2 2 2 0 CAF1 complex subunit p150, region binding to PCNA 2OG-FeII_Oxy_3 PF13640.6 EFC40640.1 - 4.9e-11 43.4 0.0 9.3e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 EFC40640.1 - 0.04 13.4 0.0 0.063 12.8 0.0 1.3 1 0 0 1 1 1 0 Oxygenase, catalysing oxidative methylation of damaged DNA Aida_C2 PF14186.6 EFC40640.1 - 0.042 13.5 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 Cytoskeletal adhesion Pkinase PF00069.25 EFC40641.1 - 4.8e-11 42.5 3.0 7.4e-11 41.9 3.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40641.1 - 1.7e-10 40.7 0.8 2.8e-10 39.9 0.8 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC40641.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Nipped-B_C PF12830.7 EFC40641.1 - 0.023 14.7 0.1 0.055 13.4 0.1 1.7 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus SusD-like_3 PF14322.6 EFC40641.1 - 0.07 13.5 0.1 2.9 8.2 0.1 2.3 2 0 0 2 2 2 0 Starch-binding associating with outer membrane Kelch_4 PF13418.6 EFC40642.1 - 1.5e-16 60.1 6.9 4e-08 33.1 0.0 4.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC40642.1 - 4e-15 55.1 3.8 7.8e-07 28.8 0.2 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EFC40642.1 - 8.5e-14 51.3 7.8 1.4e-06 28.3 0.3 4.3 4 1 1 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFC40642.1 - 3e-13 49.7 4.8 4.4e-05 23.6 0.1 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC40642.1 - 8.6e-11 41.6 2.5 0.0032 17.4 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFC40642.1 - 3.3e-10 39.4 4.2 4.5e-06 26.1 0.3 3.4 3 0 0 3 3 3 2 Kelch motif EF-hand_1 PF00036.32 EFC40643.1 - 1.4e-23 80.6 5.7 1.7e-05 24.0 0.2 5.2 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EFC40643.1 - 5.6e-22 78.0 2.5 1.3e-10 41.5 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC40643.1 - 3.1e-18 64.1 8.9 0.0013 18.4 0.0 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EFC40643.1 - 1.3e-14 52.9 10.8 9.3e-07 28.1 0.0 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 EFC40643.1 - 7e-13 48.2 3.1 4.4e-07 29.6 0.2 3.5 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 EFC40643.1 - 0.00028 21.1 0.2 6.3 7.2 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC40643.1 - 0.012 15.9 0.0 4.1 7.8 0.0 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 EFC40643.1 - 0.087 11.3 0.0 0.16 10.5 0.0 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5580) DHH PF01368.20 EFC40644.1 - 2.9e-08 33.9 0.0 4.4e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 DHH family Kinesin PF00225.23 EFC40645.1 - 1.1e-101 340.1 0.1 2.4e-101 339.0 0.1 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC40645.1 - 8.3e-19 68.0 0.1 3.9e-18 65.8 0.1 2.2 1 0 0 1 1 1 1 Microtubule binding Kinesin_assoc PF16183.5 EFC40645.1 - 3.9e-14 53.2 5.9 2.8e-10 40.6 3.2 4.2 2 2 1 4 4 4 2 Kinesin-associated CsgF PF10614.9 EFC40645.1 - 0.063 13.5 0.3 25 5.1 0.1 3.0 2 0 0 2 2 2 0 Type VIII secretion system (T8SS), CsgF protein RhoGAP PF00620.27 EFC40646.1 - 7.1e-42 142.8 0.8 1.4e-41 141.9 0.8 1.5 1 0 0 1 1 1 1 RhoGAP domain WW PF00397.26 EFC40646.1 - 3.9e-08 33.2 5.8 1e-07 31.9 5.8 1.8 1 0 0 1 1 1 1 WW domain FSA_C PF10479.9 EFC40646.1 - 0.028 12.6 14.0 0.044 11.9 14.0 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF4419 PF14388.6 EFC40647.1 - 2e-70 237.6 1.7 2e-70 237.6 1.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4419) GATA PF00320.27 EFC40647.1 - 1.5e-10 40.5 8.8 3.6e-10 39.3 8.8 1.6 1 0 0 1 1 1 1 GATA zinc finger F-box-like PF12937.7 EFC40647.1 - 6.7e-07 29.1 1.2 1.4e-06 28.0 1.2 1.6 1 0 0 1 1 1 1 F-box-like HSP70 PF00012.20 EFC40647.1 - 3.2e-05 22.3 0.0 6.4e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 Hsp70 protein F-box PF00646.33 EFC40647.1 - 0.00023 20.9 1.1 0.00053 19.8 1.1 1.6 1 0 0 1 1 1 1 F-box domain ADD_DNMT3 PF17980.1 EFC40647.1 - 0.012 15.6 0.2 0.031 14.3 0.2 1.7 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 Orf78 PF06024.12 EFC40648.1 - 0.00039 20.7 1.1 0.038 14.3 0.0 2.1 2 0 0 2 2 2 1 Orf78 (ac78) CrgA PF06781.12 EFC40648.1 - 0.0028 17.7 0.1 0.0046 17.0 0.0 1.4 1 1 0 1 1 1 1 Cell division protein CrgA DHHC PF01529.20 EFC40648.1 - 0.1 12.7 3.1 0.14 12.3 3.1 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF4234 PF14018.6 EFC40648.1 - 0.6 10.3 6.5 1.4 9.1 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4234) BatA PF07584.11 EFC40648.1 - 1.2 9.6 4.2 0.41 11.0 0.3 1.9 1 1 1 2 2 2 0 Aerotolerance regulator N-terminal DUF3810 PF12725.7 EFC40648.1 - 2.3 7.5 4.4 3 7.1 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) EVC2_like PF12297.8 EFC40648.1 - 3 6.4 5.7 9.8 4.7 0.0 2.0 1 1 1 2 2 2 0 Ellis van Creveld protein 2 like protein SSB PF00436.25 EFC40649.1 - 4.2e-18 65.3 0.5 7.5e-18 64.5 0.5 1.4 1 0 0 1 1 1 1 Single-strand binding protein family AF-4 PF05110.13 EFC40649.1 - 0.0035 15.5 10.0 0.0037 15.5 10.0 1.0 1 0 0 1 1 1 1 AF-4 proto-oncoprotein R_equi_Vir PF05526.11 EFC40649.1 - 0.046 13.6 0.7 0.071 13.0 0.7 1.3 1 0 0 1 1 1 0 Rhodococcus equi virulence-associated protein Miff PF05644.11 EFC40649.1 - 0.062 12.9 1.6 0.08 12.6 1.6 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff SR-25 PF10500.9 EFC40649.1 - 5 6.7 15.5 7.8 6.0 15.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LRR_8 PF13855.6 EFC40650.1 - 1.3e-08 34.5 9.7 8.2e-05 22.3 2.0 3.8 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC40650.1 - 8.5e-08 32.4 13.9 0.00021 21.6 0.3 5.2 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC40650.1 - 1.9e-05 24.3 11.8 0.15 12.2 0.2 5.5 5 0 0 5 5 5 2 Leucine Rich repeat LRR_9 PF14580.6 EFC40650.1 - 0.0077 15.7 0.3 0.084 12.4 0.2 2.1 1 1 1 2 2 2 1 Leucine-rich repeat Lactamase_B_3 PF13483.6 EFC40651.1 - 0.099 12.5 0.2 0.22 11.4 0.2 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain YL1 PF05764.13 EFC40651.1 - 2.7 8.0 14.8 5.1 7.1 14.8 1.4 1 0 0 1 1 1 0 YL1 nuclear protein SIS PF01380.22 EFC40652.1 - 5.6e-37 126.5 0.1 1.2e-20 73.7 0.0 2.3 2 0 0 2 2 2 2 SIS domain GATase_7 PF13537.6 EFC40652.1 - 2.8e-14 53.1 0.0 5.5e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFC40652.1 - 2.4e-13 50.4 0.0 5.7e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain Ras PF00071.22 EFC40653.1 - 1.4e-23 83.3 0.7 9.6e-23 80.6 0.7 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC40653.1 - 2.6e-08 34.1 1.3 3.9e-06 27.1 1.3 2.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC40653.1 - 0.00074 19.1 0.0 0.0025 17.4 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC40653.1 - 0.003 17.0 0.0 0.0079 15.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC40653.1 - 0.005 16.8 0.0 1.3 8.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC40653.1 - 0.0085 16.2 0.3 0.61 10.2 0.3 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.22 EFC40653.1 - 0.059 12.5 0.0 0.11 11.7 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain MMR_HSR1_Xtn PF16897.5 EFC40653.1 - 0.085 12.9 0.2 0.24 11.5 0.2 1.8 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Sina PF03145.16 EFC40653.1 - 0.095 12.6 0.6 0.6 10.0 0.3 1.9 2 0 0 2 2 2 0 Seven in absentia protein family IBR PF01485.21 EFC40654.1 - 1.1e-11 44.7 50.3 1.8e-08 34.4 13.4 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFC40654.1 - 0.0064 16.3 3.6 0.0064 16.3 3.6 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC40654.1 - 0.0067 16.4 2.3 0.0067 16.4 2.3 3.3 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC40654.1 - 0.023 14.5 2.3 0.023 14.5 2.3 4.3 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF2142 PF09913.9 EFC40655.1 - 0.035 13.0 7.4 0.021 13.7 5.5 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2142) PIRT PF15099.6 EFC40655.1 - 1 9.0 8.2 6.2 6.4 4.5 2.7 2 1 0 2 2 2 0 Phosphoinositide-interacting protein family Jagunal PF07086.12 EFC40655.1 - 1.4 9.0 6.8 21 5.1 0.9 2.5 1 1 2 3 3 3 0 Jagunal, ER re-organisation during oogenesis DUF996 PF06195.13 EFC40655.1 - 1.5 9.1 13.5 0.93 9.8 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF996) DUF2207 PF09972.9 EFC40655.1 - 7.9 5.1 14.1 0.69 8.6 0.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Ala_racemase_N PF01168.20 EFC40656.1 - 1.5e-50 171.9 0.0 2e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Ala_racemase_C PF00842.21 EFC40656.1 - 3.5e-39 133.4 0.2 7.1e-39 132.4 0.2 1.5 1 0 0 1 1 1 1 Alanine racemase, C-terminal domain HEAT PF02985.22 EFC40657.1 - 0.014 15.6 2.9 8.7 6.9 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat Glyco_transf_10 PF00852.19 EFC40658.1 - 3.8e-28 98.4 0.0 6.9e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DUF639 PF04842.12 EFC40658.1 - 0.0025 17.3 0.0 0.0042 16.5 0.0 1.2 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) DUF667 PF05018.13 EFC40659.1 - 2e-28 99.4 1.4 4.2e-28 98.3 1.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Pkinase PF00069.25 EFC40660.1 - 4.6e-34 118.0 1.9 8.3e-34 117.1 1.9 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40660.1 - 2.1e-22 79.7 0.2 3.4e-22 79.0 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC40660.1 - 4.6e-11 42.2 0.8 1.6e-05 24.7 0.0 5.8 6 0 0 6 6 6 1 NHL repeat EGF_2 PF07974.13 EFC40660.1 - 0.00019 21.8 23.2 0.00036 20.8 12.1 2.7 2 0 0 2 2 2 2 EGF-like domain YrbL-PhoP_reg PF10707.9 EFC40660.1 - 0.0056 16.2 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL EGF PF00008.27 EFC40660.1 - 0.017 15.4 12.6 0.048 14.0 6.5 2.8 2 0 0 2 2 2 0 EGF-like domain Pkinase_fungal PF17667.1 EFC40660.1 - 0.045 12.5 0.0 0.075 11.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SGL PF08450.12 EFC40660.1 - 0.1 12.1 0.0 0.75 9.3 0.0 2.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region hEGF PF12661.7 EFC40660.1 - 1 10.1 16.9 1.9 9.3 9.3 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF Cys_Met_Meta_PP PF01053.20 EFC40661.1 - 1.9e-35 122.1 2.5 5.4e-35 120.6 2.5 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFC40661.1 - 0.00034 19.9 0.1 0.00047 19.4 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II AAA PF00004.29 EFC40662.1 - 4.4e-17 62.7 0.0 8.7e-16 58.5 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 EFC40662.1 - 1e-14 54.7 0.4 2.3e-14 53.6 0.2 1.7 2 0 0 2 2 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 EFC40662.1 - 1.1e-14 54.5 0.0 4.9e-13 49.2 0.0 2.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EFC40662.1 - 1.1e-06 28.7 0.0 2.6e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EFC40662.1 - 3.8e-06 26.7 0.0 1.1e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC40662.1 - 0.0002 21.6 0.4 0.094 13.0 0.1 3.3 2 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 EFC40662.1 - 0.00042 19.8 0.0 0.003 17.0 0.0 2.1 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 EFC40662.1 - 0.00043 20.7 0.1 0.007 16.8 0.0 2.5 2 1 1 3 3 3 1 AAA ATPase domain AAA_assoc_2 PF16193.5 EFC40662.1 - 0.0008 19.7 0.1 0.0074 16.6 0.0 2.5 2 0 0 2 2 2 1 AAA C-terminal domain ResIII PF04851.15 EFC40662.1 - 0.0057 16.7 0.0 0.023 14.7 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EFC40662.1 - 0.0081 16.0 0.1 0.018 14.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC40662.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFC40662.1 - 0.026 14.9 0.0 0.076 13.4 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_5 PF07728.14 EFC40662.1 - 0.03 14.3 0.0 0.09 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Nse5 PF08691.10 EFC40662.1 - 0.049 12.3 0.1 0.071 11.8 0.1 1.1 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 IstB_IS21 PF01695.17 EFC40662.1 - 0.07 12.9 0.0 0.22 11.2 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 EFC40662.1 - 0.08 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC40662.1 - 0.13 11.7 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFC40662.1 - 0.14 11.6 0.0 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein PHTB1_N PF14727.6 EFC40663.1 - 1.4e-152 508.9 0.0 1.9e-152 508.4 0.0 1.2 1 0 0 1 1 1 1 PTHB1 N-terminus PHTB1_C PF14728.6 EFC40663.1 - 2.6e-97 326.3 0.6 3.6e-97 325.8 0.6 1.1 1 0 0 1 1 1 1 PTHB1 C-terminus Nckap1 PF09735.9 EFC40664.1 - 0 1160.1 22.2 0 1159.9 22.2 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Ank_2 PF12796.7 EFC40665.1 - 2.1e-09 37.9 0.2 1.6e-05 25.4 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC40665.1 - 2.6e-06 27.6 0.6 0.7 10.3 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC40665.1 - 7.4e-06 26.4 1.6 0.27 11.8 0.0 3.5 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC40665.1 - 0.00027 21.1 0.3 14 6.6 0.1 3.6 3 0 0 3 3 3 1 Ankyrin repeat nsp7 PF08716.10 EFC40665.1 - 0.038 14.6 0.2 0.1 13.2 0.2 1.7 1 0 0 1 1 1 0 nsp7 replicase CMAS PF02353.20 EFC40665.1 - 0.041 13.2 0.0 0.079 12.2 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ank PF00023.30 EFC40665.1 - 0.12 12.9 0.5 16 6.2 0.1 3.2 3 0 0 3 3 3 0 Ankyrin repeat Ribonuclease_T2 PF00445.18 EFC40666.1 - 2.4e-42 145.2 0.7 2.4e-42 145.2 0.7 2.0 3 0 0 3 3 3 1 Ribonuclease T2 family DUF900 PF05990.12 EFC40666.1 - 0.0039 16.7 0.0 0.0073 15.8 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF726 PF05277.12 EFC40666.1 - 0.0091 15.0 0.0 0.014 14.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Ser_hydrolase PF06821.13 EFC40666.1 - 0.049 13.5 0.2 0.59 10.0 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase Rad52_Rad22 PF04098.15 EFC40667.1 - 3.3e-48 163.5 0.0 5.5e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Cut8 PF08559.10 EFC40668.1 - 4.4e-32 111.6 9.9 4.4e-32 111.6 9.9 2.0 1 1 1 2 2 2 1 Cut8, nuclear proteasome tether protein DUF4576 PF15144.6 EFC40668.1 - 0.098 12.5 0.3 0.23 11.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) MDFI PF15316.6 EFC40668.1 - 0.51 10.4 6.9 1.3 9.0 6.9 1.6 1 0 0 1 1 1 0 MyoD family inhibitor CHD5 PF04420.14 EFC40669.1 - 0.083 12.8 0.1 0.18 11.6 0.1 1.6 1 0 0 1 1 1 0 CHD5-like protein ETRAMP PF09716.10 EFC40669.1 - 0.25 11.4 6.2 12 6.0 0.0 2.7 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TRIQK PF15168.6 EFC40669.1 - 0.52 10.2 3.4 2.6 8.0 0.4 2.5 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family DUF2207 PF09972.9 EFC40669.1 - 4.1 6.0 13.0 1.4 7.6 0.2 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) SMC_N PF02463.19 EFC40670.1 - 4.4e-15 55.7 31.2 1e-14 54.5 31.2 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFC40670.1 - 2.1e-09 37.7 0.2 1.6e-08 34.9 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SbcCD_C PF13558.6 EFC40670.1 - 0.04 14.2 0.1 0.14 12.4 0.1 2.0 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit bMG3 PF11974.8 EFC40670.1 - 0.052 13.6 0.0 0.2 11.7 0.0 2.0 1 0 0 1 1 1 0 Bacterial alpha-2-macroglobulin MG3 domain DEAD PF00270.29 EFC40670.1 - 0.054 13.3 0.2 0.054 13.3 0.2 3.0 3 0 0 3 3 3 0 DEAD/DEAH box helicase hSac2 PF12456.8 EFC40671.1 - 0.03 14.1 0.2 0.091 12.5 0.2 1.8 1 0 0 1 1 1 0 Inositol phosphatase DUF5052 PF16475.5 EFC40671.1 - 0.063 12.9 2.0 0.12 12.0 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5052) DUF1761 PF08570.10 EFC40672.1 - 7.2e-20 71.5 6.8 8.2e-20 71.3 6.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) DUF2177 PF09945.9 EFC40672.1 - 0.00059 19.9 1.1 0.00059 19.9 1.1 1.5 1 1 0 1 1 1 1 Predicted membrane protein (DUF2177) PrsW-protease PF13367.6 EFC40672.1 - 0.68 9.4 8.1 0.79 9.1 6.3 2.0 1 1 0 1 1 1 0 PrsW family intramembrane metalloprotease Zn_clus PF00172.18 EFC40673.1 - 4.6e-09 36.2 7.3 9.9e-09 35.2 7.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pre-SET PF05033.16 EFC40674.1 - 4.8e-17 62.6 5.4 4.8e-17 62.6 5.4 2.8 3 0 0 3 3 3 1 Pre-SET motif SET PF00856.28 EFC40674.1 - 9.9e-17 61.8 0.2 7.6e-16 59.0 0.1 2.5 2 1 0 2 2 2 1 SET domain AMP-binding PF00501.28 EFC40675.1 - 1.5e-33 116.1 0.0 2.2e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme RRM_1 PF00076.22 EFC40676.1 - 5.2e-80 263.2 7.0 2.6e-20 72.0 0.0 4.9 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 EFC40676.1 - 1.8e-27 95.3 0.6 2.9e-25 88.2 0.7 2.7 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 EFC40676.1 - 9.2e-08 31.9 0.2 0.3 11.0 0.1 4.1 4 0 0 4 4 4 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFC40676.1 - 1.2e-07 31.7 0.9 0.3 11.1 0.0 4.5 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFC40676.1 - 3e-07 30.5 0.3 0.044 13.9 0.0 4.8 4 3 0 4 4 4 1 RNA recognition motif Nup35_RRM PF05172.13 EFC40676.1 - 1.6e-06 28.0 0.6 0.016 15.1 0.0 4.2 3 1 1 4 4 4 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 EFC40676.1 - 1.8e-06 27.9 1.5 0.65 10.1 0.0 4.4 3 1 1 4 4 4 2 Limkain b1 DUF4523 PF15023.6 EFC40676.1 - 5.3e-05 23.1 0.1 3.4 7.5 0.0 3.8 2 2 2 4 4 4 2 Protein of unknown function (DUF4523) SET_assoc PF11767.8 EFC40676.1 - 0.016 14.8 0.2 34 4.2 0.0 3.7 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated Cas_Cas2CT1978 PF09707.10 EFC40676.1 - 0.12 12.4 0.0 5.9 7.0 0.0 3.0 3 0 0 3 3 3 0 CRISPR-associated protein (Cas_Cas2CT1978) tRNA_anti-like PF12869.7 EFC40676.1 - 0.56 9.8 3.9 0.15 11.7 0.5 1.7 2 0 0 2 2 2 0 tRNA_anti-like RabGAP-TBC PF00566.18 EFC40677.1 - 5.4e-39 134.1 8.6 1.1e-38 133.1 8.6 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 EFC40677.1 - 1.6e-08 34.2 0.3 1.2e-07 31.3 0.0 2.4 3 0 0 3 3 3 1 Rab-binding domain (RBD) COX6B PF02297.17 EFC40678.1 - 0.02 15.1 0.7 0.02 15.1 0.7 2.7 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Pet191_N PF10203.9 EFC40678.1 - 1.5 9.2 9.5 0.1 12.9 1.5 2.6 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 WD40 PF00400.32 EFC40680.1 - 0.00078 20.2 0.1 0.023 15.6 0.1 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Ribosomal_L37e PF01907.19 EFC40681.1 - 7.4e-26 90.1 7.1 7.4e-26 90.1 7.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L37e DZR PF12773.7 EFC40681.1 - 0.018 15.1 1.2 0.031 14.3 1.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon Rubredoxin_2 PF18073.1 EFC40681.1 - 0.18 11.6 4.5 5 6.9 0.2 2.7 3 0 0 3 3 3 0 Rubredoxin metal binding domain IPPT PF01715.17 EFC40682.1 - 1.6e-56 191.7 0.9 1.6e-56 191.7 0.9 1.7 2 0 0 2 2 2 1 IPP transferase IPT PF01745.16 EFC40682.1 - 1.2e-11 44.4 0.0 2.1e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 Isopentenyl transferase ResIII PF04851.15 EFC40682.1 - 0.0016 18.5 1.7 0.0043 17.1 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_33 PF13671.6 EFC40682.1 - 0.0019 18.4 0.2 0.21 11.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 EFC40682.1 - 0.0028 17.6 0.1 0.055 13.5 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 EFC40682.1 - 0.0076 15.5 0.0 0.0076 15.5 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Cytidylate_kin2 PF13189.6 EFC40682.1 - 0.0088 16.2 0.2 0.022 14.9 0.0 1.8 2 0 0 2 2 2 1 Cytidylate kinase-like family Hydin_ADK PF17213.3 EFC40682.1 - 0.021 15.1 0.6 0.049 13.9 0.0 1.9 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_19 PF13245.6 EFC40682.1 - 0.032 14.6 0.1 0.099 13.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFC40682.1 - 0.053 13.9 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 EFC40682.1 - 0.065 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein RsgA_GTPase PF03193.16 EFC40682.1 - 0.065 13.1 2.4 0.18 11.7 0.1 2.4 2 0 0 2 2 2 0 RsgA GTPase T2SSE PF00437.20 EFC40682.1 - 0.067 12.2 0.5 0.13 11.3 0.1 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF853 PF05872.12 EFC40682.1 - 0.069 11.7 0.1 0.11 11.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AAA_18 PF13238.6 EFC40682.1 - 0.1 13.2 0.0 0.1 13.2 0.0 3.0 3 1 0 3 3 3 0 AAA domain AAA_11 PF13086.6 EFC40682.1 - 0.11 12.2 1.7 0.69 9.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFC40682.1 - 2.6 8.5 11.5 0.72 10.3 0.7 2.4 2 0 0 2 2 2 0 AAA domain SIR2 PF02146.17 EFC40683.1 - 1.9e-23 83.3 9.4 2.6e-20 73.1 0.1 3.2 3 1 1 4 4 3 2 Sir2 family TPR_2 PF07719.17 EFC40683.1 - 8.7e-12 44.2 3.2 0.00039 20.3 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40683.1 - 2.2e-11 43.0 9.3 3.8e-05 23.3 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-MYND PF01753.18 EFC40683.1 - 2.2e-08 34.0 11.2 2.2e-08 34.0 11.2 2.9 3 0 0 3 3 3 1 MYND finger TPR_12 PF13424.6 EFC40683.1 - 3.6e-07 30.4 0.7 1.6e-06 28.3 0.1 2.4 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40683.1 - 5.4e-07 29.6 3.2 4.4e-06 26.7 0.1 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40683.1 - 2.2e-06 27.2 1.0 0.00018 21.1 0.0 3.0 2 1 1 3 3 3 2 TPR repeat TPR_19 PF14559.6 EFC40683.1 - 0.00021 21.8 0.1 0.00058 20.3 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40683.1 - 0.00093 19.2 11.9 0.0021 18.1 0.2 4.6 5 0 0 5 5 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC40683.1 - 0.014 14.8 0.1 7.8 6.0 0.0 2.8 2 0 0 2 2 2 0 SHNi-TPR DUF5113 PF17140.4 EFC40683.1 - 0.019 14.8 0.2 0.063 13.1 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 EFC40683.1 - 0.019 15.2 0.6 0.019 15.2 0.6 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFC40683.1 - 0.096 13.3 0.0 0.48 11.1 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC40683.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40683.1 - 0.2 12.6 0.0 5.4 8.1 0.0 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat zf-C6H2 PF15801.5 EFC40683.1 - 9.1 6.7 16.5 4 7.8 10.8 2.8 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding F-box-like PF12937.7 EFC40684.1 - 3.5e-05 23.6 0.1 0.00011 22.0 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC40684.1 - 0.0053 16.6 0.0 0.025 14.5 0.0 2.2 1 0 0 1 1 1 1 F-box domain DUF3306 PF11748.8 EFC40684.1 - 0.0074 17.1 1.3 0.018 15.9 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3306) LRR_4 PF12799.7 EFC40684.1 - 0.51 10.8 14.1 0.78 10.3 1.8 5.1 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC40684.1 - 1 9.2 5.2 3.4 7.5 1.6 3.7 3 0 0 3 3 3 0 Leucine rich repeat T6PP_N PF18572.1 EFC40684.1 - 8.1 6.3 8.4 4.7 7.1 0.7 3.6 3 0 0 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Pkinase PF00069.25 EFC40685.1 - 1.8e-40 139.0 0.1 2.9e-40 138.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40685.1 - 7e-26 91.0 0.0 9.9e-26 90.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC40685.1 - 0.0083 15.5 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC40685.1 - 0.19 11.6 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Sec6 PF06046.13 EFC40686.1 - 3.3e-05 22.5 0.1 4.1e-05 22.2 0.1 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 DUF5305 PF17231.2 EFC40686.1 - 0.056 12.8 2.9 0.083 12.3 2.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) RNA_pol_Rpb8 PF03870.15 EFC40687.1 - 7e-49 165.6 0.7 8.6e-49 165.3 0.7 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 EFC40687.1 - 7.5e-07 29.2 3.6 8.7e-05 22.6 0.1 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G 3H PF02829.14 EFC40687.1 - 0.13 12.5 0.1 0.25 11.7 0.1 1.4 1 0 0 1 1 1 0 3H domain BBE PF08031.12 EFC40688.1 - 3.6e-12 46.2 3.6 9e-12 44.9 3.6 1.7 1 0 0 1 1 1 1 Berberine and berberine like CCDC24 PF15669.5 EFC40688.1 - 0.013 15.4 0.0 0.019 14.9 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family MAPEG PF01124.18 EFC40689.1 - 2.4e-12 46.9 1.3 3e-12 46.6 1.3 1.1 1 0 0 1 1 1 1 MAPEG family TPR_1 PF00515.28 EFC40690.1 - 0.00015 21.4 1.3 0.0012 18.6 0.4 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC40690.1 - 0.00024 21.0 0.7 0.014 15.4 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Sel1 PF08238.12 EFC40690.1 - 0.007 17.0 0.1 0.21 12.3 0.0 2.4 2 0 0 2 2 2 1 Sel1 repeat TPR_8 PF13181.6 EFC40690.1 - 0.007 16.5 0.7 0.007 16.5 0.7 3.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40690.1 - 0.009 16.0 0.1 0.07 13.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40690.1 - 0.025 14.2 0.3 0.058 13.1 0.3 1.6 1 0 0 1 1 1 0 TPR repeat TPR_6 PF13174.6 EFC40690.1 - 0.11 13.2 0.1 16 6.4 0.0 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat nec1 PF10379.9 EFC40690.1 - 0.17 11.4 0.5 0.28 10.6 0.5 1.3 1 0 0 1 1 1 0 Virulence protein nec1 DUF5106 PF17127.4 EFC40690.1 - 0.18 12.1 2.1 0.14 12.4 0.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) FmiP_Thoc5 PF09766.9 EFC40692.1 - 5.3e-76 256.3 7.3 5.3e-76 256.3 7.3 1.7 2 0 0 2 2 2 1 Fms-interacting protein/Thoc5 Orai-1 PF07856.12 EFC40692.1 - 0.028 14.1 0.0 0.1 12.3 0.0 1.9 2 0 0 2 2 2 0 Mediator of CRAC channel activity Ribosomal_L7Ae PF01248.26 EFC40693.1 - 9.2e-27 92.6 0.2 1.2e-26 92.3 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 EFC40693.1 - 0.00027 20.8 0.0 0.00038 20.3 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 EFC40693.1 - 0.019 15.0 0.1 0.023 14.8 0.1 1.2 1 0 0 1 1 1 0 RNase P subunit Pop3 Linker_histone PF00538.19 EFC40693.1 - 0.15 12.4 1.5 16 6.0 0.0 2.1 2 0 0 2 2 2 0 linker histone H1 and H5 family TH1 PF04858.13 EFC40695.1 - 7.2e-132 441.0 7.6 1.5e-131 440.0 7.6 1.4 1 1 0 1 1 1 1 TH1 protein TetR_C_8 PF14278.6 EFC40695.1 - 3.1 8.0 6.4 6.3 7.0 0.1 3.9 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region hSac2 PF12456.8 EFC40696.1 - 0.0031 17.2 0.1 0.01 15.5 0.1 1.9 1 0 0 1 1 1 1 Inositol phosphatase SNAD1 PF18744.1 EFC40696.1 - 0.014 15.3 0.2 0.027 14.3 0.2 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 1 Kinesin PF00225.23 EFC40697.1 - 1.1e-97 327.0 0.7 1.1e-97 327.0 0.7 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC40697.1 - 3.8e-25 88.6 0.1 3.8e-25 88.6 0.1 2.9 2 1 0 2 2 2 1 Microtubule binding Kinesin_assoc PF16183.5 EFC40697.1 - 0.0012 19.1 3.9 0.0012 19.1 3.9 1.8 2 0 0 2 2 2 1 Kinesin-associated Mucin_bdg PF03272.13 EFC40697.1 - 0.0018 18.3 0.6 0.0065 16.5 0.1 2.1 2 0 0 2 2 2 1 Putative mucin or carbohydrate-binding module DUF5301 PF17225.3 EFC40697.1 - 1.8 9.0 12.0 1.5 9.3 0.9 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF5300) Actin PF00022.19 EFC40698.1 - 2.2e-113 379.0 0.0 9.4e-113 376.9 0.0 1.7 1 1 0 1 1 1 1 Actin Metallophos PF00149.28 EFC40699.1 - 2.3e-38 132.8 0.2 2.9e-38 132.4 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFC40699.1 - 0.00049 20.5 0.9 0.0013 19.2 0.9 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Cyclin_N PF00134.23 EFC40700.1 - 5.6e-38 129.5 4.2 3.9e-37 126.8 0.6 2.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC40700.1 - 2.3e-25 89.0 4.5 5e-25 87.9 2.2 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 EFC40700.1 - 0.0029 17.6 0.0 0.057 13.5 0.0 2.4 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 EFC40700.1 - 0.22 12.0 0.0 0.22 12.0 0.0 2.3 3 0 0 3 3 3 0 Cyclin C-terminal domain LRR_4 PF12799.7 EFC40701.1 - 1.6e-08 34.7 28.5 0.0019 18.6 5.8 4.8 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC40701.1 - 4e-06 26.5 19.6 0.00016 21.4 0.5 4.3 3 1 2 5 5 5 2 Leucine rich repeat LRR_6 PF13516.6 EFC40701.1 - 4.5e-05 23.2 1.0 4.5e-05 23.2 1.0 6.2 6 1 1 7 7 7 1 Leucine Rich repeat LRR_1 PF00560.33 EFC40701.1 - 0.0052 17.1 20.7 2.6 8.9 0.2 6.6 5 1 1 6 6 6 2 Leucine Rich Repeat F-box PF00646.33 EFC40701.1 - 0.061 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 F-box domain SR-25 PF10500.9 EFC40704.1 - 3.1 7.3 24.2 3.8 7.0 24.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ANAPC1 PF12859.7 EFC40704.1 - 4.2 7.9 7.6 5.4 7.6 7.6 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 MFS_1 PF07690.16 EFC40705.1 - 1.9e-11 43.5 58.0 9.9e-10 37.9 32.6 3.7 2 1 1 3 3 3 3 Major Facilitator Superfamily Na_trans_assoc PF06512.13 EFC40705.1 - 2.1 8.6 5.7 0.13 12.5 0.2 1.7 2 0 0 2 2 2 0 Sodium ion transport-associated TMPIT PF07851.13 EFC40706.1 - 1.8e-105 352.8 14.4 2.2e-105 352.5 14.4 1.0 1 0 0 1 1 1 1 TMPIT-like protein UPF0086 PF01868.16 EFC40707.1 - 1.8e-25 88.6 0.1 4.1e-25 87.5 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function UPF0086 IBN_N PF03810.19 EFC40708.1 - 3.1e-12 46.2 1.9 1.7e-10 40.7 0.2 4.3 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 EFC40708.1 - 2.3e-06 27.8 0.3 2.3e-06 27.8 0.3 6.8 7 1 1 8 8 8 1 Exportin 1-like protein Cse1 PF08506.10 EFC40708.1 - 3.2e-06 26.2 0.2 2.1e-05 23.5 0.0 2.4 2 0 0 2 2 2 1 Cse1 HEAT_EZ PF13513.6 EFC40708.1 - 9.6e-05 22.8 0.2 0.004 17.6 0.0 4.0 5 0 0 5 5 5 1 HEAT-like repeat HEAT PF02985.22 EFC40708.1 - 0.00081 19.4 4.3 11 6.6 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 EFC40708.1 - 0.0012 19.2 0.0 0.072 13.5 0.0 3.2 2 0 0 2 2 2 1 HEAT repeats RIX1 PF08167.12 EFC40708.1 - 0.0032 17.2 4.9 0.017 14.9 0.0 4.3 4 1 1 5 5 5 1 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 EFC40708.1 - 0.036 14.2 0.5 2.7 8.2 0.1 4.2 3 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 EFC40708.1 - 0.075 12.9 8.6 1.9 8.4 0.2 4.1 4 1 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Arm PF00514.23 EFC40708.1 - 3 8.0 4.5 36 4.6 0.2 4.6 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat GCIP PF13324.6 EFC40708.1 - 3.2 7.3 11.4 1 8.9 6.6 2.6 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting Kelch_6 PF13964.6 EFC40709.1 - 1.1e-07 31.8 0.3 0.012 15.9 0.4 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFC40709.1 - 3.7e-07 30.1 0.4 0.00093 19.2 0.0 3.9 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC40709.1 - 1.3e-06 28.2 0.2 0.029 14.4 0.2 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 EFC40709.1 - 8.5e-05 22.4 0.5 0.089 12.8 0.2 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFC40709.1 - 0.0059 16.9 0.1 0.74 10.2 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC40709.1 - 0.1 12.2 1.0 0.57 9.8 0.1 2.6 3 0 0 3 3 3 0 Kelch motif Tn7_Tnp_TnsA_C PF08721.11 EFC40710.1 - 0.09 13.4 0.4 2.3 8.9 0.0 2.8 3 1 0 3 3 3 0 TnsA endonuclease C terminal MeaB PF03308.16 EFC40710.1 - 0.091 11.7 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Ras PF00071.22 EFC40711.1 - 1.8e-06 27.6 0.1 3e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Ras family Calcyon PF06387.11 EFC40711.1 - 0.093 12.7 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Phage_integrase PF00589.22 EFC40713.1 - 0.0052 16.6 0.0 0.0083 15.9 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family Baculo_LEF5 PF04838.12 EFC40713.1 - 0.084 12.9 0.2 0.17 11.9 0.2 1.5 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 Acetyltransf_1 PF00583.25 EFC40714.1 - 5.6e-12 45.9 0.0 9.7e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC40714.1 - 1.8e-06 28.3 0.0 3.9e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC40714.1 - 0.0004 20.3 0.0 0.00085 19.2 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 EFC40714.1 - 0.00041 20.3 0.0 0.0011 19.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC40714.1 - 0.00067 19.7 0.1 0.021 14.9 0.1 2.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EFC40714.1 - 0.063 13.3 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase RGS PF00615.19 EFC40717.1 - 8.8e-06 26.0 1.1 8.8e-06 26.0 1.1 3.1 3 1 0 3 3 3 1 Regulator of G protein signaling domain Orf78 PF06024.12 EFC40717.1 - 0.014 15.7 5.4 2.4 8.5 1.0 3.0 2 0 0 2 2 2 0 Orf78 (ac78) PriX PF18689.1 EFC40717.1 - 0.078 13.3 0.5 0.41 11.0 0.0 2.6 3 0 0 3 3 3 0 Primase X DUF4577 PF15145.6 EFC40717.1 - 5.3 7.1 7.1 1.4 8.9 1.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4577) NLRC4_HD PF17889.1 EFC40718.1 - 0.0003 21.1 0.7 0.00059 20.1 0.7 1.5 1 0 0 1 1 1 1 NLRC4 helical domain Ank_3 PF13606.6 EFC40719.1 - 0.00026 21.2 0.0 0.85 10.4 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC40719.1 - 0.00044 20.7 0.0 0.0073 16.9 0.0 2.4 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC40719.1 - 0.002 18.6 0.0 0.0078 16.8 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Glyco_transf_7C PF02709.14 EFC40719.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Nsp1_C PF05064.13 EFC40721.1 - 6e-22 77.6 6.8 6e-22 77.6 6.8 2.3 1 1 0 2 2 2 1 Nsp1-like C-terminal region Miga PF10265.9 EFC40721.1 - 0.00023 20.3 3.4 0.00031 19.9 3.4 1.1 1 0 0 1 1 1 1 Mitoguardin IL15 PF02372.15 EFC40721.1 - 0.0073 16.3 1.6 0.019 15.0 1.5 1.7 1 1 0 1 1 1 1 Interleukin 15 MKT1_C PF12246.8 EFC40721.1 - 0.058 12.6 2.4 0.23 10.7 2.4 1.8 1 1 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication Taxilin PF09728.9 EFC40721.1 - 0.077 12.2 9.0 0.12 11.6 1.5 2.1 2 0 0 2 2 2 0 Myosin-like coiled-coil protein NPV_P10 PF05531.12 EFC40721.1 - 0.14 12.7 5.7 1.4 9.5 1.7 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.6 EFC40721.1 - 0.24 11.1 7.7 0.12 12.1 5.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF3450 PF11932.8 EFC40721.1 - 0.32 10.3 7.5 0.5 9.6 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) MscS_porin PF12795.7 EFC40721.1 - 0.35 10.4 10.5 0.069 12.7 1.2 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DUF4795 PF16043.5 EFC40721.1 - 0.54 9.8 8.4 0.84 9.2 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) BLOC1_2 PF10046.9 EFC40721.1 - 0.59 10.5 9.8 0.17 12.2 3.9 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Allexi_40kDa PF05549.11 EFC40721.1 - 0.94 8.9 6.7 0.71 9.3 4.7 1.8 1 1 1 2 2 2 0 Allexivirus 40kDa protein Sec34 PF04136.15 EFC40721.1 - 1.2 9.0 8.4 2 8.3 7.1 1.8 1 1 1 2 2 2 0 Sec34-like family Spore_III_AB PF09548.10 EFC40721.1 - 1.9 8.6 3.6 0.78 9.8 1.0 1.6 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) WXG100 PF06013.12 EFC40721.1 - 2.2 8.6 5.0 1.4 9.2 2.4 2.0 2 1 0 2 2 1 0 Proteins of 100 residues with WXG Spc24 PF08286.11 EFC40721.1 - 2.4 8.4 8.5 5.8 7.2 1.2 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 CENP-Q PF13094.6 EFC40721.1 - 3.2 7.9 6.0 8.2 6.6 6.0 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit APG6_N PF17675.1 EFC40721.1 - 4.9 7.7 9.9 4.8 7.7 7.5 1.8 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 EFC40721.1 - 7.1 6.7 7.6 17 5.5 1.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) GMP_synt_C PF00958.22 EFC40722.1 - 4.2e-42 142.1 0.0 7.9e-42 141.2 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 EFC40722.1 - 2.8e-29 102.2 0.3 4.5e-29 101.6 0.3 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 EFC40722.1 - 2.1e-10 40.7 0.3 5.4e-10 39.4 0.3 1.8 1 1 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 EFC40722.1 - 3.6e-09 36.1 0.1 1.3e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 NAD synthase tRNA_Me_trans PF03054.16 EFC40722.1 - 1.1e-05 24.5 0.1 0.00017 20.5 0.1 2.4 3 0 0 3 3 3 1 tRNA methyl transferase QueC PF06508.13 EFC40722.1 - 0.00014 21.4 0.0 0.27 10.7 0.0 2.3 1 1 1 2 2 2 2 Queuosine biosynthesis protein QueC ThiI PF02568.14 EFC40722.1 - 0.00029 20.5 0.0 0.00082 19.0 0.0 1.8 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) GATase_3 PF07685.14 EFC40722.1 - 0.0054 16.3 0.0 0.0097 15.5 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain PAPS_reduct PF01507.19 EFC40722.1 - 0.0098 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family GATase_5 PF13507.6 EFC40722.1 - 0.09 11.9 0.0 0.17 11.0 0.0 1.4 1 1 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Asn_synthase PF00733.21 EFC40722.1 - 0.12 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase tRNA-synt_2b PF00587.25 EFC40723.1 - 1e-18 68.0 0.2 7.7e-18 65.1 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFC40723.1 - 9e-17 61.0 1.8 1.8e-16 60.1 0.3 2.4 3 0 0 3 3 3 1 Anticodon binding domain tRNA_SAD PF07973.14 EFC40723.1 - 0.0009 19.3 0.2 0.0023 18.0 0.2 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 EFC40723.1 - 0.0078 16.2 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain LRR_6 PF13516.6 EFC40724.1 - 4.1e-11 42.0 25.2 0.0067 16.4 0.0 8.6 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 EFC40724.1 - 4.5e-07 30.1 34.5 0.013 15.9 0.8 7.3 4 2 5 9 9 9 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC40724.1 - 0.00014 21.5 28.8 0.037 13.8 0.7 6.6 3 2 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 EFC40724.1 - 0.00096 19.4 25.8 2.4 9.0 0.2 8.5 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC40724.1 - 0.0034 16.9 11.7 1.1 8.8 0.4 3.3 2 1 0 3 3 3 3 Leucine-rich repeat F-box-like PF12937.7 EFC40724.1 - 0.061 13.2 0.5 0.19 11.6 0.5 1.9 1 0 0 1 1 1 0 F-box-like Mucin PF01456.17 EFC40725.1 - 7.7 6.5 15.1 13 5.8 15.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Na_trans_cytopl PF11933.8 EFC40726.1 - 0.069 13.0 2.6 2.1 8.1 0.0 2.7 1 1 1 2 2 2 0 Cytoplasmic domain of voltage-gated Na+ ion channel Kelch_4 PF13418.6 EFC40728.1 - 4e-23 81.2 3.7 1.1e-09 38.1 0.0 6.3 6 0 0 6 6 6 2 Galactose oxidase, central domain BTB PF00651.31 EFC40728.1 - 1.2e-20 73.8 8.4 8.2e-10 38.9 0.2 3.8 3 1 1 4 4 4 2 BTB/POZ domain Kelch_1 PF01344.25 EFC40728.1 - 8.2e-20 70.1 1.5 6.9e-09 35.2 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EFC40728.1 - 1.4e-19 69.6 1.3 7e-07 29.1 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFC40728.1 - 1.6e-18 66.3 4.1 2e-06 27.9 0.1 5.6 5 1 1 6 6 5 2 Kelch motif Kelch_3 PF13415.6 EFC40728.1 - 1.8e-15 56.8 2.8 3e-05 24.2 0.0 5.3 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC40728.1 - 7.1e-14 51.1 1.7 8.1e-08 32.0 0.0 4.9 5 0 0 5 5 5 2 Kelch motif RAG2 PF03089.14 EFC40728.1 - 0.00024 20.2 0.4 0.18 10.8 0.0 3.3 3 2 0 3 3 3 2 Recombination activating protein 2 BACK PF07707.15 EFC40728.1 - 0.005 16.9 0.3 0.054 13.6 0.0 2.6 2 0 0 2 2 2 1 BTB And C-terminal Kelch YL1 PF05764.13 EFC40728.1 - 0.92 9.6 13.6 1.2 9.1 13.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF1700 PF08006.11 EFC40728.1 - 1.3 8.5 5.1 3.7 7.1 5.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) AAA PF00004.29 EFC40730.1 - 0.0056 17.1 0.0 0.07 13.6 0.0 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC40730.1 - 0.012 15.9 0.0 0.19 12.0 0.0 2.6 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFC40730.1 - 0.074 13.0 0.0 14 5.5 0.0 2.6 3 0 0 3 3 3 0 NTPase DEAD PF00270.29 EFC40730.1 - 0.084 12.6 0.1 13 5.5 0.0 3.1 3 0 0 3 3 3 0 DEAD/DEAH box helicase UDPGT PF00201.18 EFC40731.1 - 2.2e-06 26.8 0.0 0.0018 17.1 0.0 2.2 2 0 0 2 2 2 2 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 EFC40731.1 - 4.8e-05 23.4 0.0 0.0001 22.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain Patatin PF01734.22 EFC40732.1 - 2.9e-21 76.6 0.0 9.3e-21 74.9 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase MSA-2c PF12238.8 EFC40732.1 - 0.68 9.9 10.8 0.29 11.1 1.6 2.8 2 0 0 2 2 2 0 Merozoite surface antigen 2c HATPase_c PF02518.26 EFC40734.1 - 2.2e-19 70.0 2.8 4.5e-19 69.0 0.7 2.6 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC40734.1 - 2.5e-18 66.3 1.3 6.4e-18 65.0 0.4 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 EFC40734.1 - 2e-10 40.5 0.3 8.2e-10 38.6 0.2 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain FHA_2 PF17913.1 EFC40734.1 - 0.0027 17.9 0.7 0.34 11.2 0.0 2.7 2 0 0 2 2 2 1 FHA domain Ras PF00071.22 EFC40735.1 - 2.5e-58 196.3 0.1 2.9e-58 196.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40735.1 - 2e-32 111.9 0.0 2.9e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40735.1 - 1.5e-13 50.6 0.0 1.7e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC40735.1 - 1.6e-07 31.4 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC40735.1 - 6.4e-06 25.7 0.1 7.9e-06 25.4 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC40735.1 - 1.2e-05 24.9 0.0 0.00077 19.1 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC40735.1 - 0.00043 20.2 0.1 0.093 12.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EFC40735.1 - 0.00089 18.7 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Septin PF00735.18 EFC40735.1 - 0.0062 15.9 0.2 0.021 14.1 0.1 1.8 2 0 0 2 2 2 1 Septin PduV-EutP PF10662.9 EFC40735.1 - 0.011 15.5 0.1 0.33 10.7 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation G-alpha PF00503.20 EFC40735.1 - 0.035 13.3 1.6 0.2 10.8 0.3 2.0 1 1 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 EFC40735.1 - 0.055 13.5 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Dynamin family TniB PF05621.11 EFC40735.1 - 0.068 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein DLIC PF05783.11 EFC40735.1 - 0.074 11.9 0.1 0.13 11.1 0.0 1.4 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 EFC40735.1 - 0.13 12.6 0.0 0.31 11.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 EFC40735.1 - 0.14 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Guanylate_cyc PF00211.20 EFC40736.1 - 4.6e-28 98.1 0.0 1.3e-27 96.6 0.0 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40736.1 - 3e-13 49.9 0.1 8.6e-13 48.4 0.1 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC40736.1 - 3.9e-10 39.7 0.0 8.7e-10 38.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC40736.1 - 0.0057 16.1 2.3 0.0082 15.6 0.5 2.1 2 0 0 2 2 2 1 Heme NO binding associated TraG-D_C PF12696.7 EFC40736.1 - 0.049 13.6 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG PAS_4 PF08448.10 EFC40736.1 - 0.19 12.0 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 PAS fold Guanylate_cyc PF00211.20 EFC40737.1 - 3e-11 43.3 0.0 4.5e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain F-box-like PF12937.7 EFC40738.1 - 1.2e-07 31.5 0.4 1e-06 28.5 0.0 2.5 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 EFC40738.1 - 5.9e-05 22.8 0.1 0.00025 20.8 0.1 2.2 1 0 0 1 1 1 1 F-box domain ADH_N_2 PF16884.5 EFC40739.1 - 8.6e-12 44.9 0.0 2.6e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFC40739.1 - 3e-08 33.7 0.0 1.9e-07 31.1 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC40739.1 - 2e-07 32.1 0.0 3.9e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TetR_C_37 PF18665.1 EFC40739.1 - 0.078 13.6 0.2 0.19 12.4 0.2 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Rhomboid PF01694.22 EFC40740.1 - 0.051 13.6 4.3 0.093 12.7 4.2 1.6 1 1 0 1 1 1 0 Rhomboid family MACPF PF01823.19 EFC40741.1 - 2.1e-11 44.3 0.7 5.4e-11 43.0 0.7 1.6 1 1 0 1 1 1 1 MAC/Perforin domain DUF3536 PF12055.8 EFC40741.1 - 0.022 14.1 0.3 0.052 12.9 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3536) Abhydrolase_6 PF12697.7 EFC40742.1 - 3.2e-17 63.9 0.0 6.3e-17 62.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC40742.1 - 1.9e-12 46.9 0.0 3.8e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC40742.1 - 3.1e-09 36.9 1.0 2.1e-07 30.9 0.5 2.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EFC40742.1 - 2.5e-05 24.5 0.0 5.7e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 EFC40742.1 - 0.00045 20.0 0.3 0.0013 18.5 0.1 1.9 1 1 1 2 2 2 1 PGAP1-like protein Lipase_3 PF01764.25 EFC40742.1 - 0.0014 18.5 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) LIDHydrolase PF10230.9 EFC40742.1 - 0.015 14.8 0.1 0.047 13.2 0.1 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_5 PF12695.7 EFC40742.1 - 0.04 13.7 0.0 0.082 12.7 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 EFC40742.1 - 0.1 12.5 0.0 0.45 10.3 0.0 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold F-box-like PF12937.7 EFC40743.1 - 9.6e-07 28.6 0.3 2.3e-06 27.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC40743.1 - 0.00094 19.0 0.4 0.0028 17.5 0.4 1.8 1 0 0 1 1 1 1 F-box domain FPP PF05911.11 EFC40744.1 - 0.0036 15.6 9.5 0.004 15.4 9.5 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil DUF4094 PF13334.6 EFC40744.1 - 0.009 16.4 1.8 0.009 16.4 1.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4094) OEP PF02321.18 EFC40744.1 - 0.063 13.1 6.7 0.083 12.7 6.7 1.1 1 0 0 1 1 1 0 Outer membrane efflux protein HAGH_C PF16123.5 EFC40745.1 - 0.071 13.6 1.0 14 6.2 0.1 2.8 2 1 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus Imm27 PF15590.6 EFC40745.1 - 1.7 8.4 4.9 1.4 8.7 0.4 2.8 3 0 0 3 3 3 0 Immunity protein 27 Methyltransf_15 PF09445.10 EFC40746.1 - 5.2e-07 29.4 0.1 1.1e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Penicil_amidase PF01804.18 EFC40747.1 - 1.5e-157 526.5 0.0 1.9e-157 526.2 0.0 1.1 1 0 0 1 1 1 1 Penicillin amidase Pox_A14 PF05767.12 EFC40747.1 - 0.0034 17.5 3.7 0.21 11.8 0.1 2.7 2 1 0 2 2 2 2 Poxvirus virion envelope protein A14 DHHC PF01529.20 EFC40747.1 - 1.7 8.8 5.0 7.3 6.7 2.2 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase SUR7 PF06687.12 EFC40747.1 - 2.7 7.5 8.9 14 5.3 0.0 2.5 2 0 0 2 2 2 0 SUR7/PalI family Phage_holin_3_6 PF07332.11 EFC40747.1 - 9.3 6.3 9.3 2.9 7.9 3.7 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III EGF_2 PF07974.13 EFC40748.1 - 1.1e-76 252.8 377.7 4.9e-05 23.6 5.7 24.5 24 0 0 24 24 24 23 EGF-like domain EGF PF00008.27 EFC40748.1 - 1.7e-05 25.0 277.6 0.0034 17.6 5.8 24.4 24 0 0 24 24 24 12 EGF-like domain RGS PF00615.19 EFC40748.1 - 0.00011 22.5 3.5 0.00011 22.5 3.5 2.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain EI24 PF07264.11 EFC40748.1 - 0.00013 22.3 0.5 0.0036 17.6 0.0 2.9 2 1 1 3 3 3 1 Etoposide-induced protein 2.4 (EI24) Kelch_6 PF13964.6 EFC40748.1 - 0.0078 16.5 7.1 7.2 7.1 0.1 5.0 4 0 0 4 4 4 2 Kelch motif Syndecan PF01034.20 EFC40748.1 - 0.021 14.7 1.4 0.062 13.2 1.4 1.8 1 0 0 1 1 1 0 Syndecan domain LisH PF08513.11 EFC40749.1 - 4.1e-05 23.4 0.1 0.0001 22.2 0.1 1.7 1 0 0 1 1 1 1 LisH LisH_TPL PF17814.1 EFC40749.1 - 0.002 17.7 0.0 0.0064 16.1 0.0 1.9 1 0 0 1 1 1 1 LisH-like dimerisation domain UPF0160 PF03690.13 EFC40750.1 - 3.9e-129 430.8 0.0 4.4e-129 430.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF5497 PF17601.2 EFC40750.1 - 0.024 14.9 0.1 0.058 13.7 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5497) MAF_flag10 PF01973.18 EFC40750.1 - 0.03 14.0 0.2 0.047 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF115 FliL PF03748.14 EFC40751.1 - 0.084 13.5 1.5 12 6.5 0.1 4.0 4 0 0 4 4 4 0 Flagellar basal body-associated protein FliL zf-H2C2_2 PF13465.6 EFC40751.1 - 8.3 7.0 15.4 10 6.7 0.0 4.4 4 0 0 4 4 4 0 Zinc-finger double domain DUF4046 PF13255.6 EFC40752.1 - 0.053 14.1 0.1 0.14 12.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4046) DUF223 PF02721.14 EFC40752.1 - 0.26 11.6 0.0 0.26 11.6 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function DUF223 Mucin PF01456.17 EFC40752.1 - 2.8 7.9 15.5 0.44 10.5 2.5 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein AD PF09793.9 EFC40753.1 - 2.6e-21 75.5 1.3 3.7e-21 75.1 0.0 1.9 2 1 0 2 2 2 1 Anticodon-binding domain PH_12 PF16457.5 EFC40753.1 - 0.055 14.0 0.1 0.055 14.0 0.1 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain Zip PF02535.22 EFC40753.1 - 0.21 10.8 5.9 0.26 10.5 5.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EFC40753.1 - 0.21 10.3 6.1 0.3 9.8 6.1 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 EFC40753.1 - 7.1 5.1 14.2 8.8 4.8 14.2 1.2 1 0 0 1 1 1 0 Macoilin family ASCH PF04266.14 EFC40754.1 - 8.5e-16 58.5 0.0 2.9e-15 56.8 0.0 2.0 2 0 0 2 2 2 1 ASCH domain zf-C2HC5 PF06221.13 EFC40754.1 - 3.5e-07 30.1 0.6 7.4e-07 29.1 0.6 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type RecR PF02132.15 EFC40754.1 - 0.1 12.2 2.5 0.87 9.2 0.6 2.6 2 0 0 2 2 2 0 RecR protein Polysacc_deac_2 PF04748.13 EFC40754.1 - 0.2 10.8 0.4 0.41 9.8 0.2 1.5 1 1 0 1 1 1 0 Divergent polysaccharide deacetylase SHNi-TPR PF10516.9 EFC40754.1 - 0.31 10.5 1.6 0.39 10.2 0.2 1.8 2 0 0 2 2 2 0 SHNi-TPR Ras PF00071.22 EFC40756.1 - 8.3e-26 90.5 0.0 1.8e-25 89.4 0.0 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40756.1 - 5.7e-14 52.4 0.0 1.3e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40756.1 - 5.2e-05 22.8 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC40756.1 - 0.0039 17.3 0.0 0.0087 16.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC40756.1 - 0.0048 16.4 0.7 0.39 10.1 0.0 2.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit OKR_DC_1_N PF03709.15 EFC40756.1 - 0.0062 16.8 0.1 0.49 10.7 0.0 2.4 2 0 0 2 2 2 1 Orn/Lys/Arg decarboxylase, N-terminal domain Toxin_TOLIP PF00087.21 EFC40757.1 - 0.049 13.9 4.7 0.07 13.4 4.7 1.3 1 0 0 1 1 1 0 Snake toxin and toxin-like protein Activin_recp PF01064.23 EFC40757.1 - 0.27 12.3 4.6 0.48 11.6 4.6 1.6 1 1 0 1 1 1 0 Activin types I and II receptor domain Abhydrolase_3 PF07859.13 EFC40758.1 - 1.2e-45 156.0 0.0 1.5e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFC40758.1 - 8.5e-13 48.0 0.1 3.4e-12 46.0 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 EFC40758.1 - 9.1e-07 28.1 0.7 1.2e-06 27.7 0.7 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 EFC40758.1 - 0.00012 21.1 0.0 0.00014 20.9 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Esterase PF00756.20 EFC40758.1 - 0.16 11.5 0.0 19 4.8 0.0 2.2 2 0 0 2 2 2 0 Putative esterase ADH_zinc_N PF00107.26 EFC40759.1 - 5.3e-20 71.7 0.0 1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC40759.1 - 3.1e-15 57.4 0.0 5.2e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PI3K_rbd PF00794.18 EFC40759.1 - 0.049 13.8 0.0 0.32 11.2 0.0 2.2 2 0 0 2 2 2 0 PI3-kinase family, ras-binding domain TEA PF01285.18 EFC40760.1 - 0.029 14.5 0.2 0.084 13.0 0.2 1.8 1 0 0 1 1 1 0 TEA/ATTS domain Cytochrom_B559 PF00283.19 EFC40761.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits Kinocilin PF15033.6 EFC40762.1 - 0.92 9.2 3.7 1.9 8.1 0.5 2.1 2 0 0 2 2 2 0 Kinocilin protein FAM176 PF14851.6 EFC40763.1 - 6.9 6.3 6.7 3.1 7.5 1.2 2.7 3 0 0 3 3 3 0 FAM176 family MMR_HSR1 PF01926.23 EFC40764.1 - 6.5e-19 68.1 0.7 2.1e-18 66.5 0.0 2.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC40764.1 - 3.9e-11 43.1 3.6 1.4e-06 28.3 0.5 2.5 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 EFC40764.1 - 2.8e-07 30.2 0.0 6e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFC40764.1 - 1.1e-06 28.4 3.8 9.2e-05 22.1 0.4 3.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IIGP PF05049.13 EFC40764.1 - 0.00029 20.0 0.4 0.00065 18.9 0.0 1.8 1 1 0 1 1 1 1 Interferon-inducible GTPase (IIGP) SRPRB PF09439.10 EFC40764.1 - 0.0008 18.9 1.3 0.0012 18.4 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit AIG1 PF04548.16 EFC40764.1 - 0.0011 18.3 0.0 0.0011 18.3 0.0 1.8 2 0 0 2 2 2 1 AIG1 family KDGP_aldolase PF07071.11 EFC40764.1 - 0.0015 18.4 0.1 0.0036 17.1 0.0 1.6 2 0 0 2 2 2 1 KDGP aldolase RNA_helicase PF00910.22 EFC40764.1 - 0.002 18.5 1.4 0.09 13.2 0.0 3.1 2 1 1 3 3 3 1 RNA helicase Roc PF08477.13 EFC40764.1 - 0.01 16.1 1.7 0.017 15.4 0.1 2.5 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PNTB PF02233.16 EFC40764.1 - 0.017 14.1 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit cobW PF02492.19 EFC40764.1 - 0.021 14.4 0.2 0.37 10.4 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 EFC40764.1 - 0.032 14.3 11.3 0.39 10.8 0.3 3.9 3 1 1 4 4 4 0 Dynamin family RabGAP-TBC PF00566.18 EFC40765.1 - 1.9e-52 178.0 8.8 1.9e-52 178.0 8.8 2.0 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Pneumovirus_M2 PF06436.11 EFC40765.1 - 0.022 14.2 0.6 0.059 12.9 0.6 1.7 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) PH PF00169.29 EFC40766.1 - 0.0028 18.1 0.1 0.013 16.0 0.1 2.2 2 1 0 2 2 2 1 PH domain Exo_endo_phos PF03372.23 EFC40767.1 - 4.1e-05 23.2 0.0 5.8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5110 PF17137.4 EFC40767.1 - 0.094 13.0 0.4 0.2 11.9 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) Peptidase_M3 PF01432.20 EFC40768.1 - 5.5e-111 372.1 2.2 5.7e-111 372.0 0.3 1.9 2 0 0 2 2 2 1 Peptidase family M3 RTC4 PF14474.6 EFC40768.1 - 3.1 8.0 5.6 2.7 8.2 0.6 2.9 3 0 0 3 3 3 0 RTC4-like domain V_ATPase_I PF01496.19 EFC40769.1 - 0.17 9.8 8.3 0.27 9.1 8.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 EFC40769.1 - 0.35 9.7 4.6 0.57 9.0 4.6 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein RP-C_C PF11800.8 EFC40769.1 - 0.44 10.6 4.4 0.89 9.6 4.4 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region STN1_2 PF09170.10 EFC40769.1 - 2.1 8.5 10.4 3.7 7.7 9.1 2.0 2 0 0 2 2 2 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 CCDC106 PF15794.5 EFC40769.1 - 7 6.3 15.5 0.34 10.6 5.0 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 RB_A PF01858.17 EFC40770.1 - 6.8e-43 146.8 5.5 2.3e-42 145.1 5.5 2.0 1 0 0 1 1 1 1 Retinoblastoma-associated protein A domain RB_B PF01857.20 EFC40770.1 - 4.5e-29 101.2 3.8 4.5e-29 101.2 3.8 2.2 3 0 0 3 3 3 1 Retinoblastoma-associated protein B domain DUF3452 PF11934.8 EFC40770.1 - 0.02 14.4 1.4 0.88 9.1 1.4 3.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) Ras PF00071.22 EFC40771.1 - 8e-57 191.4 0.0 9.6e-57 191.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40771.1 - 3.4e-19 69.2 0.1 6.4e-19 68.3 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40771.1 - 1.1e-08 34.7 0.0 1.3e-08 34.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC40771.1 - 1e-05 25.5 0.4 0.015 15.2 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC40771.1 - 2e-05 24.2 0.1 0.00013 21.5 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC40771.1 - 0.0041 17.2 0.0 0.0086 16.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC40771.1 - 0.081 12.7 0.8 1.8 8.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein DUF4042 PF13251.6 EFC40772.1 - 2.5e-59 200.0 18.9 4.3e-58 196.0 4.5 6.2 5 2 1 6 6 6 1 Domain of unknown function (DUF4042) HEAT PF02985.22 EFC40772.1 - 3.3e-28 95.3 14.8 0.0074 16.5 0.1 11.0 11 0 0 11 11 11 7 HEAT repeat HEAT_2 PF13646.6 EFC40772.1 - 7e-21 74.4 0.0 0.00044 20.6 0.0 6.6 5 1 1 6 6 6 5 HEAT repeats HEAT_EZ PF13513.6 EFC40772.1 - 8.9e-21 74.0 5.3 4.4e-07 30.3 0.3 8.2 7 2 1 8 8 8 4 HEAT-like repeat Arm PF00514.23 EFC40772.1 - 6.9e-05 22.8 23.9 0.00054 19.9 0.3 8.3 10 0 0 10 10 10 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 EFC40772.1 - 0.00016 21.7 21.9 0.079 13.0 1.9 7.4 3 3 6 9 9 9 3 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 EFC40772.1 - 0.00052 20.3 2.7 20 5.6 0.0 5.4 5 1 1 6 6 6 0 TAF6 C-terminal HEAT repeat domain RICTOR_V PF14668.6 EFC40772.1 - 0.00063 19.9 0.2 1.9 8.7 0.0 4.4 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 Vac14_Fab1_bd PF12755.7 EFC40772.1 - 0.0024 18.4 7.9 0.95 10.1 0.1 6.0 5 2 3 8 8 8 2 Vacuolar 14 Fab1-binding region EF-G-binding_N PF07299.11 EFC40772.1 - 1.7 9.2 5.5 6.7 7.3 0.1 3.8 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal AAA PF00004.29 EFC40773.1 - 2.8e-31 108.7 0.0 4.8e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC40773.1 - 2.1e-07 30.6 0.0 4.6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 EFC40773.1 - 5.2e-07 29.5 0.0 1.3e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC40773.1 - 3e-05 24.0 0.0 0.00025 21.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFC40773.1 - 3.5e-05 24.3 0.0 6.8e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC40773.1 - 3.8e-05 24.1 0.0 0.0021 18.4 0.0 2.5 1 1 0 2 2 2 1 AAA ATPase domain TIP49 PF06068.13 EFC40773.1 - 0.0016 17.7 0.0 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 EFC40773.1 - 0.0018 17.8 0.0 0.0054 16.3 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 EFC40773.1 - 0.0025 18.1 0.0 0.0053 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 EFC40773.1 - 0.0026 18.1 0.0 0.013 15.9 0.0 2.2 2 0 0 2 2 2 1 RNA helicase Parvo_NS1 PF01057.17 EFC40773.1 - 0.0032 16.6 0.0 0.0059 15.7 0.0 1.3 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_33 PF13671.6 EFC40773.1 - 0.0034 17.5 0.0 0.006 16.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFC40773.1 - 0.0034 17.5 0.0 0.011 15.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EFC40773.1 - 0.0034 17.1 0.0 0.0074 16.0 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 EFC40773.1 - 0.0045 17.3 0.1 0.27 11.5 0.1 2.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFC40773.1 - 0.0061 16.6 0.0 0.021 14.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC40773.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFC40773.1 - 0.021 14.0 0.0 0.047 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DNA_pol3_delta2 PF13177.6 EFC40773.1 - 0.022 14.5 0.0 0.068 12.9 0.0 1.8 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Sigma54_activat PF00158.26 EFC40773.1 - 0.031 14.0 0.0 0.29 10.8 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain Bac_DnaA PF00308.18 EFC40773.1 - 0.037 13.9 0.0 1.5 8.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein Mg_chelatase PF01078.21 EFC40773.1 - 0.055 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Hydin_ADK PF17213.3 EFC40773.1 - 0.055 13.7 0.1 0.19 12.0 0.0 2.0 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Sigma54_activ_2 PF14532.6 EFC40773.1 - 0.071 13.2 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 EFC40773.1 - 0.077 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin PF02224.18 EFC40773.1 - 0.082 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_17 PF13207.6 EFC40773.1 - 0.12 12.8 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain CPT PF07931.12 EFC40773.1 - 0.12 12.2 0.1 0.75 9.6 0.0 2.0 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_3 PF07726.11 EFC40773.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EFC40773.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 EFC40773.1 - 0.19 11.8 0.0 0.38 10.8 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase LRR_8 PF13855.6 EFC40774.1 - 4.1e-21 74.5 41.4 1.5e-07 31.1 2.2 5.9 3 1 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC40774.1 - 1.2e-16 60.5 48.0 1.5e-05 25.2 0.4 8.5 2 2 7 10 10 10 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC40774.1 - 1.9e-16 58.6 25.2 5.5e-05 22.9 0.0 9.7 11 0 0 11 11 11 5 Leucine Rich repeat LRR_5 PF13306.6 EFC40774.1 - 7.2e-06 26.0 1.6 0.081 12.9 0.0 3.3 1 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EFC40774.1 - 0.00014 21.4 15.2 0.026 14.0 0.5 4.4 1 1 4 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 EFC40774.1 - 1.2 9.9 37.8 22 6.1 0.4 10.1 11 0 0 11 11 11 0 Leucine Rich Repeat DUF4116 PF13475.6 EFC40775.1 - 1.1e-24 85.9 21.1 3e-07 30.0 0.0 7.3 6 1 0 7 7 7 5 Domain of unknown function (DUF4116) Pyr_redox_2 PF07992.14 EFC40776.1 - 2.4e-33 115.7 0.0 3e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC40776.1 - 2.2e-10 41.0 1.0 1.8e-09 38.0 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC40776.1 - 1e-05 24.8 0.2 0.0025 17.0 0.0 2.6 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) DEP PF00610.21 EFC40776.1 - 0.00098 19.1 0.1 0.0029 17.6 0.1 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DAO PF01266.24 EFC40776.1 - 0.003 17.2 0.1 0.0083 15.7 0.1 1.7 1 1 1 2 2 2 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 EFC40776.1 - 0.0069 16.5 0.3 2.5 8.2 0.1 2.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 EFC40776.1 - 0.0089 16.5 0.0 4.4 7.8 0.0 2.7 2 0 0 2 2 2 1 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 EFC40776.1 - 0.017 14.7 0.0 0.043 13.4 0.0 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.6 EFC40776.1 - 0.03 14.5 0.0 3.2 8.0 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 EFC40776.1 - 0.059 13.6 0.8 3 8.1 0.1 2.7 2 0 0 2 2 2 0 TrkA-N domain ApbA PF02558.16 EFC40776.1 - 0.089 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 EFC40776.1 - 0.12 12.4 0.1 0.85 9.6 0.0 2.3 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus CENP-U PF13097.6 EFC40776.1 - 4.7 7.1 9.2 23 4.9 0.2 2.4 2 0 0 2 2 2 0 CENP-A nucleosome associated complex (NAC) subunit Ras PF00071.22 EFC40777.1 - 1.2e-55 187.5 0.4 1.5e-55 187.2 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40777.1 - 4.6e-33 114.0 0.2 7.3e-33 113.3 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40777.1 - 3.5e-17 62.4 0.1 4.5e-17 62.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC40777.1 - 7.7e-07 28.7 0.1 1.3e-06 28.0 0.0 1.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC40777.1 - 4.4e-05 23.1 0.3 0.00063 19.3 0.3 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC40777.1 - 6.7e-05 22.9 0.1 0.0003 20.8 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC40777.1 - 0.0008 19.7 0.0 0.0023 18.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC40777.1 - 0.00093 19.1 0.0 0.94 9.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EFC40777.1 - 0.0076 16.0 0.1 0.15 11.7 0.0 2.1 1 1 0 2 2 2 1 AAA domain Septin PF00735.18 EFC40777.1 - 0.018 14.4 0.0 0.039 13.2 0.0 1.5 2 0 0 2 2 2 0 Septin AAA_16 PF13191.6 EFC40777.1 - 0.03 14.7 0.0 0.062 13.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 EFC40777.1 - 0.038 13.7 0.2 17 5.2 0.0 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EFC40777.1 - 0.05 13.1 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EFC40777.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF3402 PF11882.8 EFC40778.1 - 1e-14 54.6 9.7 1e-14 54.6 9.7 3.8 2 1 1 4 4 4 3 Domain of unknown function (DUF3402) LPAM_1 PF08139.12 EFC40780.1 - 1.2 9.8 4.8 5 7.8 4.8 2.1 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site RCC1_2 PF13540.6 EFC40781.1 - 1.5e-08 34.2 6.4 0.0002 21.1 0.4 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC40781.1 - 7.8e-06 26.4 0.6 0.018 15.7 0.0 4.8 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Zn_clus PF00172.18 EFC40782.1 - 2.9e-08 33.7 11.5 6.5e-08 32.6 11.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BTB PF00651.31 EFC40783.1 - 2.7e-13 50.1 1.0 7.8e-13 48.6 1.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain Laminin_G_3 PF13385.6 EFC40783.1 - 2.1e-09 37.7 0.0 3.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BACK PF07707.15 EFC40783.1 - 0.043 13.9 1.0 2.2 8.4 0.1 2.9 3 0 0 3 3 3 0 BTB And C-terminal Kelch RGS PF00615.19 EFC40784.1 - 0.00052 20.3 6.2 0.0014 18.9 6.2 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain PTH2 PF01981.16 EFC40785.1 - 6.2e-20 71.6 0.0 7.5e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 YolD PF08863.10 EFC40785.1 - 0.062 13.4 0.2 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 YolD-like protein Porin_3 PF01459.22 EFC40786.1 - 2.3e-18 66.6 4.6 2.8e-18 66.3 4.6 1.1 1 0 0 1 1 1 1 Eukaryotic porin Kinesin PF00225.23 EFC40787.1 - 9.5e-93 310.7 0.3 2.1e-92 309.6 0.3 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC40787.1 - 2.3e-18 66.6 2.4 2.4e-18 66.5 0.0 2.3 3 0 0 3 3 3 1 Microtubule binding SRP_TPR_like PF17004.5 EFC40787.1 - 0.0025 17.8 1.6 0.0025 17.8 1.6 2.7 3 0 0 3 3 3 1 Putative TPR-like repeat AAA_22 PF13401.6 EFC40787.1 - 0.11 12.8 0.0 0.11 12.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF3209 PF11483.8 EFC40787.1 - 0.42 11.1 11.2 0.27 11.7 6.2 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3209) F-box-like PF12937.7 EFC40790.1 - 0.00013 21.8 1.8 0.0003 20.6 0.1 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EFC40790.1 - 0.0059 16.5 0.5 0.026 14.4 0.1 2.3 2 0 0 2 2 2 1 F-box domain Post_transc_reg PF13797.6 EFC40790.1 - 0.022 14.6 1.1 0.079 12.8 1.1 2.0 1 0 0 1 1 1 0 Post-transcriptional regulator Pribosyltran PF00156.27 EFC40791.1 - 1.3e-08 34.5 0.1 2.1e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain RGS PF00615.19 EFC40792.1 - 4.8e-06 26.8 7.7 2.8e-05 24.4 4.3 3.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain Cadherin_3 PF16184.5 EFC40793.1 - 3e-09 36.9 0.1 7.4e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 Cadherin-like Glycophorin_A PF01102.18 EFC40794.1 - 0.0022 18.2 0.8 0.075 13.3 0.0 2.3 2 0 0 2 2 2 1 Glycophorin A Orf78 PF06024.12 EFC40794.1 - 0.017 15.4 1.5 4.5 7.6 0.0 2.4 2 0 0 2 2 2 0 Orf78 (ac78) SAS4 PF15460.6 EFC40794.1 - 0.021 14.9 0.5 0.061 13.4 0.1 2.0 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 Claudin_2 PF13903.6 EFC40794.1 - 0.038 13.7 0.0 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2745 PF10922.8 EFC40794.1 - 0.051 13.9 0.0 0.17 12.2 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2745) Sigma_reg_N PF13800.6 EFC40794.1 - 0.35 11.2 7.7 4.9 7.5 1.0 2.7 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF4199 PF13858.6 EFC40794.1 - 0.99 9.8 4.7 17 5.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) p450 PF00067.22 EFC40795.1 - 7.6e-61 206.3 3.4 9.8e-61 205.9 3.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 YchF-GTPase_C PF06071.13 EFC40796.1 - 1.1e-33 115.2 0.7 3.3e-33 113.7 0.7 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFC40796.1 - 3e-19 69.2 0.2 1e-18 67.5 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC40796.1 - 1.5e-06 27.8 0.0 3.8e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B RMI1_C PF16099.5 EFC40796.1 - 0.052 13.4 0.4 0.1 12.4 0.4 1.5 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold HAD_2 PF13419.6 EFC40797.1 - 7.4e-17 62.0 2.0 3e-16 60.0 0.0 2.4 3 0 0 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFC40797.1 - 1.3e-12 47.6 0.0 2.6e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 EFC40797.1 - 2.3e-12 47.6 0.0 9.4e-10 39.1 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFC40797.1 - 0.0003 21.2 0.0 0.00073 20.0 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2247 PF10004.9 EFC40797.1 - 0.051 13.4 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) Hydrolase_3 PF08282.12 EFC40797.1 - 0.62 9.8 6.4 0.18 11.5 0.2 2.9 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase CBS PF00571.28 EFC40798.1 - 2.1e-19 69.7 0.3 0.00016 22.0 0.0 4.2 4 0 0 4 4 4 4 CBS domain LAMTOR5 PF16672.5 EFC40798.1 - 0.1 12.5 0.6 3.3 7.7 0.1 2.7 1 1 2 3 3 3 0 Ragulator complex protein LAMTOR5 F-box PF00646.33 EFC40800.1 - 9.3e-07 28.6 0.0 2.9e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ras PF00071.22 EFC40800.1 - 1.6e-05 24.6 0.2 0.00013 21.7 0.2 2.1 1 1 0 1 1 1 1 Ras family F-box-like PF12937.7 EFC40800.1 - 0.0002 21.2 0.1 0.00038 20.3 0.1 1.4 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 EFC40800.1 - 0.05 13.7 0.0 0.25 11.4 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EFC40800.1 - 0.058 12.6 0.0 0.15 11.2 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain DUF4037 PF13228.6 EFC40801.1 - 2.6e-26 92.4 0.0 5.2e-26 91.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4037) Peptidase_C1 PF00112.23 EFC40802.1 - 9.7e-52 176.2 6.6 1.3e-51 175.8 6.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC40802.1 - 3.9e-06 25.9 0.8 0.048 12.4 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC40802.1 - 0.00014 21.7 0.1 0.00032 20.5 0.1 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide DUF3328 PF11807.8 EFC40802.1 - 0.045 13.5 0.1 0.067 13.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) GST_N PF02798.20 EFC40803.1 - 2.2e-19 69.6 0.0 3.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC40803.1 - 1.6e-18 66.9 0.0 2.5e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC40803.1 - 3e-16 59.5 0.0 4.5e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC40803.1 - 1.2e-13 51.1 0.0 1.5e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC40803.1 - 5.7e-05 23.2 0.0 0.0001 22.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC40803.1 - 0.0041 17.1 0.0 0.0072 16.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pkinase PF00069.25 EFC40806.1 - 1.4e-48 165.6 1.6 1.2e-33 116.6 0.0 2.9 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40806.1 - 2.9e-33 115.3 0.0 5.2e-16 58.7 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase Kdo PF06293.14 EFC40806.1 - 0.0043 16.4 1.0 0.02 14.3 0.1 2.3 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC40806.1 - 0.024 14.0 0.1 0.06 12.7 0.0 1.6 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 EFC40806.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF573 PF04504.14 EFC40806.1 - 0.48 11.1 0.0 0.48 11.1 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function, DUF573 LRR_6 PF13516.6 EFC40807.1 - 5.9e-46 150.6 33.2 3.9e-05 23.4 0.1 15.7 16 0 0 16 16 16 11 Leucine Rich repeat LRR_8 PF13855.6 EFC40807.1 - 4.7e-28 96.7 32.6 4.9e-06 26.2 1.1 7.2 2 1 7 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EFC40807.1 - 2.8e-20 72.0 42.6 0.00093 19.5 0.3 9.1 5 3 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC40807.1 - 1.3e-09 37.9 13.1 0.0014 18.2 0.6 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EFC40807.1 - 9.1e-06 25.5 20.3 1.5 9.6 0.0 10.5 12 2 1 13 13 13 2 Leucine Rich Repeat RNA_lig_T4_1 PF09511.10 EFC40808.1 - 1.5e-31 110.0 0.4 1.5e-31 110.0 0.4 2.0 3 0 0 3 3 3 1 RNA ligase DUF3268 PF11672.8 EFC40808.1 - 1.2e-05 25.6 5.0 5.2e-05 23.5 5.0 2.2 1 1 0 1 1 1 1 zinc-finger-containing domain Death PF00531.22 EFC40808.1 - 0.21 11.8 1.3 4.1 7.6 0.1 2.9 2 0 0 2 2 2 0 Death domain PseudoU_synth_2 PF00849.22 EFC40809.1 - 7.7e-28 97.6 0.6 1.5e-27 96.6 0.0 1.8 2 0 0 2 2 2 1 RNA pseudouridylate synthase DUF3232 PF11554.8 EFC40809.1 - 0.0022 18.4 0.0 0.0065 16.8 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3232) RRM_1 PF00076.22 EFC40810.1 - 5.3e-16 58.2 2.5 6.8e-05 22.6 0.0 5.0 5 0 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OB_NTP_bind PF07717.16 EFC40810.1 - 1.7e-15 57.2 0.1 4.7e-14 52.5 0.0 2.7 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFC40810.1 - 8.5e-08 32.4 0.3 3.4e-07 30.5 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) IBR PF01485.21 EFC40810.1 - 3.1e-06 27.3 34.7 3e-05 24.2 14.5 4.7 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain FmdE PF02663.14 EFC40810.1 - 0.0086 16.1 2.1 0.05 13.7 0.1 2.8 2 0 0 2 2 2 1 FmdE, Molybdenum formylmethanofuran dehydrogenase operon ABC_tran PF00005.27 EFC40810.1 - 0.09 13.3 0.0 0.85 10.1 0.0 2.7 2 0 0 2 2 2 0 ABC transporter Syntaxin PF00804.25 EFC40811.1 - 4.5e-32 111.4 16.7 7.8e-32 110.6 16.7 1.4 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EFC40811.1 - 1.7e-10 40.7 1.5 1.7e-10 40.7 1.5 3.4 3 0 0 3 3 3 1 SNARE domain Syntaxin_2 PF14523.6 EFC40811.1 - 9.7e-05 22.7 13.2 9.7e-05 22.7 13.2 2.8 2 2 1 3 3 3 1 Syntaxin-like protein SecE PF00584.20 EFC40811.1 - 0.053 13.5 4.1 0.12 12.3 4.1 1.5 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex DUF3510 PF12022.8 EFC40811.1 - 0.066 13.6 11.9 5.3 7.4 2.2 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) Nucleolin_bd PF16725.5 EFC40811.1 - 0.083 12.6 1.8 0.31 10.7 0.2 2.7 2 0 0 2 2 2 0 Nucleolin binding domain DUF1664 PF07889.12 EFC40811.1 - 0.16 12.0 15.2 1.3 9.1 0.2 3.9 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) Noggin PF05806.12 EFC40811.1 - 0.27 11.1 1.2 0.57 10.1 1.2 1.6 1 0 0 1 1 1 0 Noggin Uso1_p115_C PF04871.13 EFC40811.1 - 0.3 11.4 16.9 0.57 10.6 10.3 2.5 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF5517 PF17639.2 EFC40811.1 - 0.38 11.1 4.7 0.78 10.1 1.9 2.8 2 1 0 2 2 2 0 Family of unknown function (DUF5517) Fzo_mitofusin PF04799.13 EFC40811.1 - 0.65 9.5 14.3 0.12 11.9 0.5 3.2 1 1 2 3 3 3 0 fzo-like conserved region Seryl_tRNA_N PF02403.22 EFC40811.1 - 0.73 10.1 12.7 0.2 11.9 0.5 3.8 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain YlbD_coat PF14071.6 EFC40811.1 - 2.6 8.3 12.3 0.11 12.7 1.8 3.2 2 1 2 4 4 4 0 Putative coat protein Herpes_US9 PF06072.11 EFC40811.1 - 3.5 7.6 6.1 12 5.8 0.0 3.3 3 0 0 3 3 3 0 Alphaherpesvirus tegument protein US9 DUF2203 PF09969.9 EFC40811.1 - 3.5 8.4 13.4 4.4 8.1 0.2 3.3 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) WXG100 PF06013.12 EFC40811.1 - 3.7 7.8 12.1 4.3 7.6 0.2 4.2 4 2 0 4 4 4 0 Proteins of 100 residues with WXG EST1 PF10374.9 EFC40811.1 - 5.1 7.7 7.6 22 5.7 7.6 2.3 1 1 0 1 1 1 0 Telomerase activating protein Est1 DUF2802 PF10975.8 EFC40811.1 - 5.7 7.1 7.9 12 6.1 0.2 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2802) DUF1090 PF06476.12 EFC40811.1 - 7.5 6.7 12.0 4.5 7.4 2.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1090) Phospholip_B PF04916.13 EFC40811.1 - 9.8 4.6 10.7 4.5 5.7 3.5 2.0 1 1 1 2 2 2 0 Phospholipase B RIO1 PF01163.22 EFC40812.1 - 3.6e-59 199.5 1.5 3.6e-59 199.5 1.5 2.2 3 0 0 3 3 3 1 RIO1 family Pkinase_fungal PF17667.1 EFC40812.1 - 0.0014 17.5 1.9 0.0014 17.5 1.9 2.4 1 1 0 2 2 2 1 Fungal protein kinase AA_kinase PF00696.28 EFC40812.1 - 0.06 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Amino acid kinase family DUF3385 PF11865.8 EFC40812.1 - 0.091 12.7 1.0 0.49 10.3 1.0 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) RICTOR_N PF14664.6 EFC40812.1 - 0.13 11.3 2.7 1.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term ATG11 PF10377.9 EFC40812.1 - 0.18 11.9 0.1 0.18 11.9 0.1 2.7 3 0 0 3 3 3 0 Autophagy-related protein 11 APH PF01636.23 EFC40812.1 - 0.19 11.6 0.0 5.1 6.9 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family ComC PF03047.14 EFC40812.1 - 2.6 7.9 4.4 3.1 7.7 0.1 3.1 3 0 0 3 3 3 0 COMC family Exo_endo_phos PF03372.23 EFC40813.1 - 1.7e-10 40.8 0.0 2.2e-09 37.2 0.0 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SpoIIP PF07454.11 EFC40813.1 - 0.012 15.1 0.1 0.016 14.7 0.1 1.3 1 1 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) zf-MYND PF01753.18 EFC40815.1 - 0.0013 18.7 5.4 0.0013 18.7 5.4 2.3 2 0 0 2 2 2 1 MYND finger ArdA PF07275.11 EFC40815.1 - 0.0046 17.6 0.4 0.023 15.3 0.1 2.2 2 0 0 2 2 2 1 Antirestriction protein (ArdA) zf-RanBP PF00641.18 EFC40815.1 - 0.007 15.7 5.9 0.028 13.7 5.9 2.2 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others PBP1_TM PF14812.6 EFC40815.1 - 1.6 9.1 9.8 4.9 7.6 9.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C6H2 PF15801.5 EFC40815.1 - 3.5 8.0 12.6 0.083 13.2 4.8 2.1 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding DZR PF12773.7 EFC40815.1 - 6.3 6.9 8.5 7 6.8 1.6 2.5 2 0 0 2 2 2 0 Double zinc ribbon NmrA PF05368.13 EFC40816.1 - 1.7e-26 93.2 0.3 2.3e-26 92.8 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC40816.1 - 3e-16 59.8 0.0 5.1e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC40816.1 - 1.9e-07 30.8 0.5 1.2e-05 24.9 0.4 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC40816.1 - 2e-05 23.8 1.2 2.5e-05 23.4 0.3 1.6 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC40816.1 - 0.00016 20.9 0.1 0.0027 16.9 0.1 2.1 2 0 0 2 2 2 1 Male sterility protein Shikimate_DH PF01488.20 EFC40816.1 - 0.0032 17.5 0.1 0.0069 16.5 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 EFC40816.1 - 0.0034 17.8 0.5 0.0074 16.7 0.5 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 EFC40816.1 - 0.0083 16.4 0.6 0.0083 16.4 0.6 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 EFC40816.1 - 0.0087 16.2 0.9 0.018 15.1 0.9 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus SRP54_N PF02881.19 EFC40816.1 - 0.013 15.7 0.1 0.072 13.3 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain GDP_Man_Dehyd PF16363.5 EFC40816.1 - 0.045 13.1 0.4 0.13 11.6 0.2 1.9 3 0 0 3 3 3 0 GDP-mannose 4,6 dehydratase EF-hand_1 PF00036.32 EFC40818.1 - 2e-07 30.0 0.3 0.014 14.9 0.1 3.9 3 0 0 3 3 3 2 EF hand LRR_8 PF13855.6 EFC40818.1 - 1.2e-06 28.2 5.6 2.4e-05 24.0 1.4 3.7 2 1 1 3 3 3 1 Leucine rich repeat EF-hand_6 PF13405.6 EFC40818.1 - 1.5e-05 24.6 0.0 0.11 12.5 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EFC40818.1 - 0.0008 19.8 4.3 0.0011 19.3 0.0 3.3 4 0 0 4 4 4 1 EF-hand domain pair LRR_4 PF12799.7 EFC40818.1 - 0.0033 17.8 15.9 0.0051 17.2 2.2 4.7 3 1 2 5 5 4 3 Leucine Rich repeats (2 copies) EF-hand_8 PF13833.6 EFC40818.1 - 0.0082 16.0 0.3 0.8 9.6 0.1 3.6 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 EFC40818.1 - 0.016 14.7 0.1 0.042 13.4 0.1 1.8 1 0 0 1 1 1 0 EF hand Ead_Ea22 PF13935.6 EFC40818.1 - 0.043 14.5 2.8 0.1 13.3 2.8 1.7 1 0 0 1 1 1 0 Ead/Ea22-like protein Ax_dynein_light PF10211.9 EFC40818.1 - 0.18 11.7 14.2 0.015 15.3 8.3 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain Seryl_tRNA_N PF02403.22 EFC40818.1 - 0.29 11.4 13.8 0.29 11.4 10.2 3.0 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain SPARC_Ca_bdg PF10591.9 EFC40818.1 - 1.8 8.9 7.0 0.26 11.6 0.7 3.0 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region TMF_TATA_bd PF12325.8 EFC40818.1 - 5.7 7.2 17.3 2 8.7 2.7 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding MMR_HSR1 PF01926.23 EFC40820.1 - 0.014 15.5 0.3 0.092 12.8 0.2 2.4 2 1 0 2 2 2 0 50S ribosome-binding GTPase ABC_tran PF00005.27 EFC40820.1 - 0.068 13.7 0.0 0.17 12.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 EFC40820.1 - 0.13 11.3 0.0 0.23 10.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Tetraspanin PF00335.20 EFC40821.1 - 0.0055 16.4 2.7 0.007 16.1 2.7 1.1 1 0 0 1 1 1 1 Tetraspanin family DUF4668 PF15701.5 EFC40821.1 - 0.011 15.6 2.1 0.016 15.0 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) DUF2207 PF09972.9 EFC40821.1 - 0.018 13.8 0.5 0.029 13.2 0.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MVP_shoulder PF11978.8 EFC40821.1 - 0.022 14.8 2.0 0.34 10.9 0.5 2.2 2 0 0 2 2 2 0 Shoulder domain DUF3043 PF11241.8 EFC40821.1 - 0.027 14.5 2.5 0.038 14.0 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF5362 PF17319.2 EFC40821.1 - 0.089 12.6 0.1 0.089 12.6 0.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5362) DUF1129 PF06570.11 EFC40821.1 - 0.31 10.5 3.5 0.43 10.0 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Pex24p PF06398.11 EFC40821.1 - 2.6 6.9 9.3 17 4.2 0.1 2.3 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin LRR_6 PF13516.6 EFC40822.1 - 1.2e-35 118.5 27.2 1.3e-05 24.8 0.0 12.6 13 0 0 13 13 13 9 Leucine Rich repeat LRR_8 PF13855.6 EFC40822.1 - 7.9e-28 96.0 24.6 4e-07 29.7 0.9 6.0 5 1 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC40822.1 - 5.1e-19 68.1 33.3 0.0014 19.0 0.1 8.3 5 2 6 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40822.1 - 2.5e-07 30.3 16.2 8.6 7.3 0.0 11.0 11 2 0 11 11 11 1 Leucine Rich Repeat F-box-like PF12937.7 EFC40822.1 - 0.0026 17.6 0.0 0.006 16.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like SHE3 PF17078.5 EFC40822.1 - 0.0034 17.2 2.2 0.0088 15.8 2.2 1.7 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 F-box PF00646.33 EFC40822.1 - 0.018 14.9 0.1 0.043 13.7 0.1 1.6 1 0 0 1 1 1 0 F-box domain AlphaC_N PF08829.10 EFC40822.1 - 0.19 11.7 2.1 1.6 8.8 0.3 3.0 2 1 0 3 3 3 0 Alpha C protein N terminal CH PF00307.31 EFC40824.1 - 2.4e-43 146.8 1.0 2.9e-26 91.8 0.1 3.4 3 0 0 3 3 3 2 Calponin homology (CH) domain EF-hand_1 PF00036.32 EFC40824.1 - 1.5e-14 52.4 6.8 1.6e-06 27.2 0.4 3.5 3 0 0 3 3 3 2 EF hand Spectrin PF00435.21 EFC40824.1 - 5.9e-14 52.4 27.3 2.3e-10 40.9 1.8 4.8 4 1 0 4 4 4 3 Spectrin repeat EF-hand_7 PF13499.6 EFC40824.1 - 8.2e-13 48.6 4.8 8.2e-13 48.6 4.8 3.2 3 0 0 3 3 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC40824.1 - 1.1e-12 46.8 4.5 3.2e-06 26.6 0.5 3.8 3 0 0 3 3 3 2 EF-hand domain EFhand_Ca_insen PF08726.10 EFC40824.1 - 1.3e-11 44.4 0.1 4.7e-11 42.6 0.1 2.1 1 0 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_5 PF13202.6 EFC40824.1 - 4.2e-10 38.6 7.4 6.9e-06 25.3 0.3 3.5 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC40824.1 - 5.6e-10 38.9 7.8 0.00073 19.3 2.5 4.0 2 1 1 3 3 3 3 EF-hand domain pair CAMSAP_CH PF11971.8 EFC40824.1 - 2.7e-09 36.7 0.1 2.1e-08 33.8 0.1 2.5 2 0 0 2 2 2 1 CAMSAP CH domain EF-hand_4 PF12763.7 EFC40824.1 - 0.0022 17.9 2.7 0.0046 16.9 0.5 2.8 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand ExbD PF02472.16 EFC40824.1 - 0.033 14.3 0.4 0.033 14.3 0.4 2.1 2 0 0 2 2 1 0 Biopolymer transport protein ExbD/TolR CH_2 PF06294.11 EFC40824.1 - 0.13 12.4 1.3 22 5.3 0.0 3.9 4 0 0 4 4 4 0 CH-like domain in sperm protein DUF1515 PF07439.11 EFC40824.1 - 0.59 10.2 4.5 0.61 10.1 1.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) Endotoxin_N PF03945.14 EFC40824.1 - 0.99 9.1 8.2 0.12 12.0 0.4 3.0 2 1 1 3 3 3 0 delta endotoxin, N-terminal domain MerR-DNA-bind PF09278.11 EFC40824.1 - 1.8 9.1 6.5 16 6.1 0.1 3.8 4 0 0 4 4 4 0 MerR, DNA binding MCU PF04678.13 EFC40824.1 - 2.8 8.0 13.1 0.56 10.3 3.4 3.5 3 1 0 3 3 3 0 Mitochondrial calcium uniporter DEAD PF00270.29 EFC40825.1 - 2.3e-11 43.8 0.1 4.6e-11 42.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase CobA_CobO_BtuR PF02572.15 EFC40825.1 - 0.0044 17.3 0.0 0.0062 16.8 0.0 1.2 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Flavi_DEAD PF07652.14 EFC40825.1 - 0.007 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Flavivirus DEAD domain NUDIX PF00293.28 EFC40826.1 - 0.00027 21.0 0.0 0.00051 20.1 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain HgmA PF04209.13 EFC40828.1 - 1.5e-194 646.6 0.2 1.7e-194 646.4 0.2 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Methyltransf_32 PF13679.6 EFC40829.1 - 7.3e-36 123.5 1.6 7.3e-36 123.5 1.6 2.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC40829.1 - 3.6e-13 49.6 2.0 4.3e-13 49.3 0.3 1.9 2 0 0 2 2 2 1 Methyltransferase domain TRM13 PF05206.14 EFC40829.1 - 1.8e-07 30.9 8.1 5.4e-06 26.1 2.6 2.8 2 1 1 3 3 3 2 Methyltransferase TRM13 Methyltransf_25 PF13649.6 EFC40829.1 - 6.7e-07 29.9 0.0 1.8e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC40829.1 - 0.00024 21.8 0.1 0.00066 20.4 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC40829.1 - 0.00027 21.5 0.0 0.00095 19.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain DUF3834 PF12916.7 EFC40829.1 - 0.029 13.6 0.7 0.085 12.1 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) C2 PF00168.30 EFC40830.1 - 4.4e-18 65.5 0.3 9.8e-18 64.3 0.3 1.6 1 0 0 1 1 1 1 C2 domain Syntaxin PF00804.25 EFC40830.1 - 2.4e-10 40.4 22.5 2.8e-10 40.2 21.7 1.6 1 1 0 1 1 1 1 Syntaxin COMP PF11598.8 EFC40830.1 - 0.028 14.9 0.7 4.6 7.8 0.0 2.8 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Syntaxin_2 PF14523.6 EFC40830.1 - 0.19 12.1 24.8 0.029 14.8 17.0 3.2 2 2 1 3 3 3 0 Syntaxin-like protein SID-1_RNA_chan PF13965.6 EFC40830.1 - 1 7.7 7.3 1.4 7.2 7.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ABC_tran PF00005.27 EFC40832.1 - 3.9e-30 105.2 10.8 1.1e-19 71.3 0.3 3.8 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EFC40832.1 - 5.1e-14 52.8 5.9 1e-05 25.6 0.2 3.8 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC40832.1 - 1.6e-05 24.5 5.8 0.031 13.7 0.0 3.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFC40832.1 - 0.001 19.7 0.2 0.001 19.7 0.2 3.4 1 1 1 2 2 1 1 AAA domain NACHT PF05729.12 EFC40832.1 - 0.0033 17.4 0.0 0.0094 15.9 0.0 1.9 2 0 0 2 2 2 1 NACHT domain T2SSE PF00437.20 EFC40832.1 - 0.0039 16.3 1.0 0.0049 16.0 0.1 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.6 EFC40832.1 - 0.0062 16.2 0.1 0.016 15.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain NB-ARC PF00931.22 EFC40832.1 - 0.0064 15.7 0.1 0.021 14.0 0.1 1.9 1 1 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.6 EFC40832.1 - 0.007 16.1 0.3 0.016 14.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFC40832.1 - 0.0073 16.2 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFC40832.1 - 0.015 15.7 0.0 0.15 12.5 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran_Xtn PF12848.7 EFC40832.1 - 0.015 15.3 8.5 0.027 14.5 8.2 1.6 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 EFC40832.1 - 0.018 14.6 0.4 0.048 13.2 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.29 EFC40832.1 - 0.03 14.1 2.6 0.37 10.5 0.5 3.2 2 2 1 3 3 3 0 DEAD/DEAH box helicase AAA_18 PF13238.6 EFC40832.1 - 0.034 14.7 1.3 0.25 11.9 0.1 2.6 2 1 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EFC40832.1 - 0.036 14.1 3.1 0.16 12.0 0.0 3.3 4 0 0 4 4 4 0 AAA domain Mg_chelatase PF01078.21 EFC40832.1 - 0.053 12.9 0.0 0.77 9.1 0.1 2.3 1 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI ATP-synt_ab PF00006.25 EFC40832.1 - 0.068 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MobB PF03205.14 EFC40832.1 - 0.096 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 EFC40832.1 - 0.1 12.6 0.7 2.4 8.1 0.0 3.4 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC40832.1 - 0.16 12.3 0.7 1.1 9.5 0.2 2.7 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFC40832.1 - 0.5 10.0 2.8 0.64 9.7 0.2 2.5 2 1 0 2 2 2 0 AAA domain RGS PF00615.19 EFC40834.1 - 3.6e-07 30.5 2.7 3.6e-07 30.5 2.7 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain HTH_40 PF14493.6 EFC40834.1 - 0.15 12.6 1.6 0.29 11.6 0.1 2.3 2 1 0 2 2 2 0 Helix-turn-helix domain Baculo_11_kDa PF06143.11 EFC40834.1 - 0.15 11.7 8.1 3.3 7.4 5.5 2.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family Reticulon PF02453.17 EFC40834.1 - 0.16 12.0 0.2 0.16 12.0 0.2 3.1 1 1 1 2 2 2 0 Reticulon Beach PF02138.18 EFC40835.1 - 4.6e-58 196.8 0.0 1.9e-57 194.7 0.0 2.1 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 EFC40835.1 - 0.00039 20.5 0.1 0.08 13.1 0.1 3.6 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH GRAM PF02893.20 EFC40835.1 - 0.063 13.2 0.9 0.89 9.5 0.1 2.8 2 1 1 3 3 3 0 GRAM domain CHAD PF05235.14 EFC40835.1 - 0.28 11.1 7.5 2.4 8.1 7.3 2.1 1 1 0 1 1 1 0 CHAD domain UQ_con PF00179.26 EFC40836.1 - 2.6e-36 124.4 0.4 3.2e-36 124.1 0.4 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC40836.1 - 0.006 16.9 0.0 0.0085 16.4 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 EFC40836.1 - 0.009 15.9 0.2 0.014 15.2 0.2 1.4 1 0 0 1 1 1 1 UEV domain Myb_DNA-binding PF00249.31 EFC40837.1 - 3.7e-26 91.1 10.6 1.7e-14 53.7 0.3 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC40837.1 - 3e-20 72.2 9.0 5.7e-13 48.9 5.1 2.9 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFC40837.1 - 7.4e-06 26.0 2.3 0.08 13.0 0.3 2.9 2 1 1 3 3 3 2 SLIDE Myb_DNA-bind_7 PF15963.5 EFC40837.1 - 0.019 14.9 2.8 2.6 8.0 0.5 2.7 2 0 0 2 2 2 0 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 EFC40837.1 - 0.04 14.3 9.6 0.55 10.6 0.6 3.3 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFC40837.1 - 0.05 13.8 3.3 4.7 7.5 0.2 3.2 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 ICAM_N PF03921.14 EFC40837.1 - 0.087 12.5 2.3 0.2 11.3 0.6 2.3 2 0 0 2 2 2 0 Intercellular adhesion molecule (ICAM), N-terminal domain DUF4065 PF13274.6 EFC40837.1 - 0.1 13.5 4.6 0.16 12.8 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4065) tRNA_anti-like PF12869.7 EFC40838.1 - 0.096 12.3 1.2 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 tRNA_anti-like F-box-like PF12937.7 EFC40839.1 - 1.9e-09 37.3 0.1 1.1e-08 34.8 0.1 2.1 2 0 0 2 2 2 1 F-box-like Ras PF00071.22 EFC40839.1 - 5.7e-08 32.5 0.7 1.7e-07 31.0 0.3 1.9 2 0 0 2 2 2 1 Ras family F-box PF00646.33 EFC40839.1 - 0.0014 18.4 0.2 0.0033 17.3 0.2 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFC40839.1 - 0.0055 16.6 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 F-box RasGAP PF00616.19 EFC40840.1 - 2.3e-31 109.2 2.3 5.1e-28 98.2 0.0 3.8 3 1 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EFC40840.1 - 3.1e-27 95.4 0.1 1.3e-26 93.4 0.1 2.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain HEAT PF02985.22 EFC40840.1 - 0.0091 16.2 0.2 1.1e+02 3.5 0.0 5.3 4 0 0 4 4 4 0 HEAT repeat Atx10homo_assoc PF09759.9 EFC40840.1 - 0.097 12.7 0.6 8 6.6 0.0 3.5 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain PX PF00787.24 EFC40841.1 - 3.6e-08 33.4 0.1 7.5e-08 32.4 0.1 1.6 1 1 0 1 1 1 1 PX domain KRE9 PF05390.11 EFC40841.1 - 0.1 13.4 1.3 0.16 12.7 1.3 1.3 1 0 0 1 1 1 0 Yeast cell wall synthesis protein KRE9/KNH1 Trypan_PARP PF05887.11 EFC40842.1 - 3.7e-07 30.2 123.4 0.027 14.5 41.7 3.1 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) IF-2B PF01008.17 EFC40843.1 - 7.4e-68 228.8 0.1 9.7e-68 228.4 0.1 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family Pfk_N PF18468.1 EFC40845.1 - 0.075 13.5 0.1 6.8 7.2 0.1 2.7 2 0 0 2 2 2 0 Phosphofructokinase N-terminal domain yeast CcmE PF03100.15 EFC40846.1 - 3.8e-30 104.5 0.0 8.2e-30 103.4 0.0 1.5 1 0 0 1 1 1 1 CcmE ALMT PF11744.8 EFC40846.1 - 1.1 8.0 15.9 2 7.1 15.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Hexapep PF00132.24 EFC40847.1 - 2.6e-15 55.4 11.5 2.3e-05 23.9 2.7 4.2 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFC40847.1 - 1.9e-06 27.5 9.1 0.048 13.4 0.1 3.9 3 1 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Pepsin-I3 PF06394.13 EFC40847.1 - 0.13 12.5 0.0 0.58 10.4 0.0 2.2 2 1 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain LRR_6 PF13516.6 EFC40848.1 - 7.3e-25 84.9 40.8 0.00055 19.8 0.0 11.5 12 0 0 12 12 12 8 Leucine Rich repeat LRR_4 PF12799.7 EFC40848.1 - 4.6e-05 23.7 32.2 0.0088 16.4 1.1 6.5 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40848.1 - 0.014 15.9 18.9 1.3 9.8 0.1 8.4 11 0 0 11 11 11 0 Leucine Rich Repeat CALCOCO1 PF07888.11 EFC40848.1 - 0.41 9.4 31.7 0.61 8.9 31.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Golgin_A5 PF09787.9 EFC40848.1 - 1.5 8.2 39.0 3.2 7.1 13.3 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 LRR_8 PF13855.6 EFC40848.1 - 4.8 7.0 28.0 1.7 8.5 0.4 7.2 4 2 1 6 6 6 0 Leucine rich repeat Scramblase PF03803.15 EFC40851.1 - 0.045 13.1 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 Scramblase Cpn60_TCP1 PF00118.24 EFC40852.1 - 3.4e-45 154.6 0.0 1.9e-24 86.2 0.0 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family RPA43_OB PF17875.1 EFC40853.1 - 0.64 10.7 6.7 0.71 10.5 0.1 2.5 2 1 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF5384 PF17358.2 EFC40853.1 - 1 9.4 10.7 1.4 8.9 1.9 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5384) BRICHOS PF04089.14 EFC40854.1 - 0.12 12.6 0.1 0.26 11.5 0.1 1.6 1 0 0 1 1 1 0 BRICHOS domain EGF_2 PF07974.13 EFC40855.1 - 1.2e-13 51.2 130.9 0.00052 20.3 11.8 10.0 8 1 1 9 9 9 7 EGF-like domain REJ PF02010.15 EFC40855.1 - 8.6e-13 47.9 14.4 8.6e-13 47.9 14.4 3.1 2 1 0 3 3 3 2 REJ domain Aa_trans PF01490.18 EFC40856.1 - 8.4e-61 205.9 44.2 1.2e-60 205.4 44.2 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EFC40856.1 - 1.6e-07 30.7 37.7 1.5e-06 27.5 37.7 2.1 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family Cnn_1N PF07989.11 EFC40856.1 - 0.0014 18.7 4.7 0.0014 18.7 4.7 2.3 2 0 0 2 2 2 1 Centrosomin N-terminal motif 1 Rootletin PF15035.6 EFC40856.1 - 0.014 15.4 4.7 0.022 14.8 4.7 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.18 EFC40856.1 - 0.015 15.5 5.7 0.034 14.4 5.7 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper NRBF2 PF08961.10 EFC40856.1 - 0.022 14.4 2.8 0.039 13.6 2.8 1.4 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 EFC40856.1 - 0.07 13.8 3.5 0.18 12.4 3.5 1.7 1 0 0 1 1 1 0 Initiation control protein YabA Seadorna_VP6 PF07407.11 EFC40856.1 - 0.097 11.6 1.3 0.2 10.5 1.3 1.5 1 0 0 1 1 1 0 Seadornavirus VP6 protein DivIC PF04977.15 EFC40856.1 - 0.16 11.8 6.5 0.85 9.4 6.5 2.4 1 0 0 1 1 1 0 Septum formation initiator IFP_35_N PF07334.13 EFC40856.1 - 0.24 11.5 7.6 0.59 10.3 7.6 1.6 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus SOGA PF11365.8 EFC40856.1 - 0.37 11.9 13.3 0.13 13.5 7.2 2.7 3 0 0 3 3 3 0 Protein SOGA GrpE PF01025.19 EFC40856.1 - 0.51 10.0 7.8 1 9.0 7.8 1.4 1 0 0 1 1 1 0 GrpE ApoL PF05461.11 EFC40856.1 - 0.69 9.2 4.2 12 5.1 4.4 2.2 2 0 0 2 2 2 0 Apolipoprotein L Spc24 PF08286.11 EFC40856.1 - 2.6 8.3 9.8 19 5.6 9.5 2.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Ras PF00071.22 EFC40857.1 - 2.1e-44 151.0 1.6 2.5e-44 150.7 1.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC40857.1 - 8.2e-28 97.0 0.2 1.5e-27 96.2 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC40857.1 - 2.8e-13 49.7 0.0 3.7e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC40857.1 - 1.2e-07 31.4 1.6 1.4e-07 31.1 1.6 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFC40857.1 - 8.9e-06 25.3 0.2 1.2e-05 24.9 0.2 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFC40857.1 - 0.00013 21.6 0.1 0.00026 20.6 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC40857.1 - 0.0017 18.3 0.2 0.023 14.6 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC40857.1 - 0.0018 18.4 0.0 0.0035 17.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MHC_I_3 PF16497.5 EFC40857.1 - 0.069 12.6 1.0 0.095 12.2 0.1 1.7 2 0 0 2 2 2 0 MHC-I family domain CSN5_C PF18323.1 EFC40858.1 - 4 8.4 8.1 16 6.5 6.5 2.5 1 1 1 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain STAG PF08514.11 EFC40859.1 - 4.3e-25 87.8 1.9 4.3e-25 87.8 1.9 4.4 4 1 0 4 4 4 1 STAG domain PPP4R2 PF09184.11 EFC40859.1 - 0.0094 15.6 0.1 0.0094 15.6 0.1 5.7 5 1 1 6 6 6 2 PPP4R2 HEAT PF02985.22 EFC40859.1 - 0.014 15.6 0.1 0.5 10.8 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat LrgA PF03788.14 EFC40859.1 - 0.093 12.7 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 LrgA family LRR_6 PF13516.6 EFC40860.1 - 4.8e-31 104.2 26.4 0.00068 19.5 0.0 10.7 11 0 0 11 11 11 8 Leucine Rich repeat LRR_8 PF13855.6 EFC40860.1 - 1.7e-18 66.1 31.9 7.4e-08 32.0 0.3 7.0 4 3 3 7 7 7 5 Leucine rich repeat LRR_4 PF12799.7 EFC40860.1 - 1.8e-18 66.3 37.2 0.0016 18.8 0.9 9.3 2 1 9 12 12 12 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40860.1 - 6.8e-10 38.1 8.9 17 6.4 0.0 10.7 11 1 1 12 12 12 2 Leucine Rich Repeat F-box-like PF12937.7 EFC40860.1 - 0.17 11.8 1.2 0.38 10.7 1.2 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC40860.1 - 0.18 11.8 1.2 0.82 9.6 0.9 2.2 2 0 0 2 2 2 0 F-box domain FAD_binding_4 PF01565.23 EFC40861.1 - 2.5e-26 92.1 0.0 4.1e-26 91.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 EFC40861.1 - 2.4e-09 37.4 0.9 8.3e-09 35.6 0.9 1.9 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase Methyltransf_11 PF08241.12 EFC40861.1 - 1.5e-08 35.1 0.0 3.8e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC40861.1 - 1.4e-07 32.1 0.1 6.5e-07 30.0 0.0 2.3 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC40861.1 - 2.7e-07 30.6 0.0 5.5e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC40861.1 - 5.7e-06 25.8 0.0 1.8e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFC40861.1 - 0.00012 22.7 0.2 0.00041 21.0 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC40861.1 - 0.00022 21.0 0.0 0.00073 19.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PAH PF02671.21 EFC40861.1 - 0.048 13.8 0.0 0.3 11.3 0.0 2.5 2 0 0 2 2 2 0 Paired amphipathic helix repeat Methyltransf_PK PF05891.12 EFC40861.1 - 0.062 12.8 0.0 0.27 10.7 0.0 2.1 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase PMT2_N PF17987.1 EFC40861.1 - 0.067 13.4 0.0 0.36 11.0 0.0 2.3 2 0 0 2 2 2 0 Phosphoethanolamine N-methyltransferase 2 N-terminal YGGT PF02325.17 EFC40861.1 - 0.098 13.1 3.4 0.17 12.4 0.3 2.8 2 1 0 2 2 2 0 YGGT family TGT PF01702.18 EFC40862.1 - 1.2e-42 146.4 0.1 1.4e-42 146.1 0.1 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Pkinase PF00069.25 EFC40863.1 - 4e-69 232.9 0.0 5.3e-69 232.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40863.1 - 1.3e-25 90.2 0.0 2.1e-25 89.5 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC40863.1 - 0.0069 15.4 0.2 0.016 14.2 0.2 1.6 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFC40863.1 - 0.032 13.8 0.1 0.064 12.8 0.1 1.5 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EFC40863.1 - 0.044 13.1 0.0 0.078 12.3 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Med21 PF11221.8 EFC40864.1 - 6.3e-10 39.5 1.0 8.2e-10 39.1 1.0 1.2 1 0 0 1 1 1 1 Subunit 21 of Mediator complex DUF148 PF02520.17 EFC40864.1 - 0.27 11.3 6.5 0.25 11.5 5.0 1.6 1 1 1 2 2 2 0 Domain of unknown function DUF148 Thioredoxin PF00085.20 EFC40865.1 - 2.9e-08 33.6 0.1 5.2e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EFC40865.1 - 7.3e-05 22.7 0.1 0.00013 21.8 0.1 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 EFC40865.1 - 0.0037 17.2 0.1 0.007 16.3 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain AKAP95 PF04988.12 EFC40865.1 - 0.013 15.7 1.9 0.022 15.0 1.9 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Glyco_hydro_10 PF00331.20 EFC40865.1 - 0.051 12.7 0.8 0.072 12.2 0.8 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 TMA7 PF09072.10 EFC40865.1 - 0.13 13.1 2.9 2.8 8.9 5.1 1.8 2 0 0 2 2 2 0 Translation machinery associated TMA7 DUF2009 PF09418.10 EFC40866.1 - 2.7e-207 689.3 0.9 3.1e-207 689.1 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) Phage_rep_org_N PF09681.10 EFC40866.1 - 0.2 11.6 1.8 0.28 11.1 0.1 2.1 3 0 0 3 3 3 0 N-terminal phage replisome organiser (Phage_rep_org_N) adh_short PF00106.25 EFC40867.1 - 4.6e-25 88.2 0.0 7.3e-24 84.3 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC40867.1 - 9.4e-17 61.3 0.0 2.8e-16 59.8 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC40867.1 - 2.4e-06 27.6 0.0 3.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF3627 PF12299.8 EFC40867.1 - 0.047 13.8 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3627) Sacchrp_dh_NADP PF03435.18 EFC40867.1 - 0.17 12.1 0.0 0.28 11.4 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Peptidase_M16_M PF16187.5 EFC40868.1 - 7.4e-61 205.9 8.6 2e-60 204.4 8.6 1.8 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EFC40868.1 - 2e-30 105.7 0.4 9.2e-30 103.6 0.4 2.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFC40868.1 - 2.4e-26 92.9 3.0 1e-18 68.0 0.3 3.8 3 0 0 3 3 3 2 Peptidase M16 inactive domain BTB PF00651.31 EFC40869.1 - 4.6e-08 33.3 0.5 3.5e-07 30.4 0.2 2.6 1 1 1 2 2 2 1 BTB/POZ domain Aldo_ket_red PF00248.21 EFC40870.1 - 3.7e-79 266.0 0.1 4.8e-79 265.6 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AAA_12 PF13087.6 EFC40871.1 - 5.6e-42 143.6 2.5 5.6e-42 143.6 2.5 2.5 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 EFC40871.1 - 8.9e-18 65.0 14.3 1.1e-17 64.7 2.1 4.0 4 1 0 4 4 4 1 AAA domain AAA_19 PF13245.6 EFC40871.1 - 1.5e-10 41.6 0.0 2.4e-08 34.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFC40871.1 - 6.7e-06 25.9 0.0 0.00021 21.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain UvrD-helicase PF00580.21 EFC40871.1 - 0.00022 20.8 8.8 0.00022 20.8 8.8 3.8 2 2 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EFC40871.1 - 0.0017 18.7 0.3 0.036 14.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EFC40871.1 - 0.0023 17.4 0.1 0.012 15.0 0.0 2.3 3 0 0 3 3 3 1 PhoH-like protein AAA PF00004.29 EFC40871.1 - 0.014 15.8 0.0 0.12 12.8 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EFC40871.1 - 0.042 13.4 0.0 0.093 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFC40871.1 - 0.043 14.2 0.0 0.18 12.2 0.0 2.1 1 0 0 1 1 1 0 RNA helicase SCO1-SenC PF02630.14 EFC40872.1 - 5e-45 152.7 0.1 8.6e-45 151.9 0.1 1.4 1 0 0 1 1 1 1 SCO1/SenC Ank_2 PF12796.7 EFC40872.1 - 6.1e-20 71.6 0.6 2.1e-09 37.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC40872.1 - 7.3e-20 70.8 1.5 0.00048 20.4 0.0 5.4 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC40872.1 - 1.2e-17 64.0 1.3 4.7e-05 23.9 0.2 4.5 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC40872.1 - 1e-13 50.0 2.4 0.0054 17.1 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 EFC40872.1 - 1.5e-09 37.9 3.9 0.013 15.9 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat AhpC-TSA PF00578.21 EFC40872.1 - 1.1e-05 25.3 0.0 3.5e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EFC40872.1 - 5.8e-05 23.3 0.0 0.00022 21.5 0.0 2.1 1 0 0 1 1 1 1 Thioredoxin-like MAGE PF01454.19 EFC40872.1 - 0.017 14.9 1.1 0.034 13.9 1.1 1.4 1 0 0 1 1 1 0 MAGE family Redoxin PF08534.10 EFC40872.1 - 0.075 12.7 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 Redoxin Trypsin_2 PF13365.6 EFC40873.1 - 4.6e-06 27.6 0.0 7.1e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 EFC40873.1 - 0.013 15.3 0.1 0.031 14.1 0.1 1.7 1 1 0 1 1 1 0 Trypsin Aconitase PF00330.20 EFC40874.1 - 1.5e-115 386.8 0.3 1.7e-114 383.4 0.3 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFC40874.1 - 1.4e-22 80.4 0.1 3.2e-22 79.3 0.1 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain ASD2 PF08687.11 EFC40874.1 - 0.19 11.2 0.7 0.36 10.4 0.7 1.4 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Peptidase_S28 PF05577.12 EFC40876.1 - 1.9e-64 218.1 0.2 4.6e-64 216.8 0.2 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EFC40876.1 - 5.2e-05 23.0 0.0 8.7e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2920 PF11144.8 EFC40876.1 - 0.00043 19.6 0.0 0.00059 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) Hydrolase_4 PF12146.8 EFC40876.1 - 0.0049 16.2 0.0 0.0069 15.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 ATP-synt_C PF00137.21 EFC40877.1 - 1.7e-22 79.5 37.7 1.1e-14 54.5 13.9 2.8 3 0 0 3 3 3 2 ATP synthase subunit C SLATT_5 PF18160.1 EFC40877.1 - 0.65 9.3 1.8 0.96 8.7 0.0 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 tRNA_edit PF04073.15 EFC40878.1 - 5.1e-07 29.8 0.0 2.2e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain Sec34 PF04136.15 EFC40878.1 - 0.01 15.7 6.9 1.1 9.1 0.2 2.3 2 0 0 2 2 2 0 Sec34-like family DUF2096 PF09869.9 EFC40878.1 - 0.038 14.1 2.0 0.11 12.6 0.8 2.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) HNH_repeat PF18780.1 EFC40878.1 - 0.11 12.4 0.7 0.24 11.2 0.7 1.6 1 0 0 1 1 1 0 Homing endonuclease repeat Allexi_40kDa PF05549.11 EFC40878.1 - 0.15 11.5 2.4 1.6 8.1 1.3 2.1 1 1 0 1 1 1 0 Allexivirus 40kDa protein CCDC53 PF10152.9 EFC40878.1 - 0.17 12.3 1.6 0.23 11.9 1.6 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex LPP20 PF02169.16 EFC40878.1 - 0.3 11.5 5.5 0.32 11.4 4.3 1.7 2 0 0 2 2 2 0 LPP20 lipoprotein CENP-F_leu_zip PF10473.9 EFC40878.1 - 0.33 11.0 4.1 0.5 10.4 4.1 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 EFC40878.1 - 0.75 10.2 5.1 0.92 10.0 0.3 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) LRR_4 PF12799.7 EFC40879.1 - 1.1e-05 25.7 47.0 0.0063 16.9 1.8 7.0 1 1 8 9 9 9 8 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC40879.1 - 0.00097 19.0 0.0 0.0034 17.2 0.0 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC40879.1 - 0.0017 18.2 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EFC40879.1 - 0.12 12.5 0.2 0.12 12.5 0.2 8.2 9 0 0 9 9 9 0 Leucine Rich repeat LRR_2 PF07723.13 EFC40879.1 - 8.9 7.2 7.6 3.7 8.4 0.5 4.1 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_1 PF00560.33 EFC40879.1 - 9.7 7.2 28.2 77 4.4 0.6 8.3 6 2 1 7 7 7 0 Leucine Rich Repeat TPR_1 PF00515.28 EFC40880.1 - 9.2e-56 183.5 1.6 6.8e-10 38.3 0.0 9.2 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EFC40880.1 - 8.5e-45 147.3 0.1 2.4e-07 30.3 0.0 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40880.1 - 1.9e-32 108.7 9.4 3.8e-05 23.6 0.2 8.9 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFC40880.1 - 1.3e-26 91.9 13.8 6.7e-07 28.9 0.0 6.8 3 2 3 6 6 6 5 TPR repeat TPR_17 PF13431.6 EFC40880.1 - 9.9e-25 85.1 5.3 0.00014 22.0 0.2 8.7 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 EFC40880.1 - 4e-21 75.0 0.0 0.00038 20.5 0.0 6.3 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40880.1 - 5.6e-18 65.0 0.3 1.6e-06 28.3 0.0 5.7 3 2 3 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40880.1 - 1.2e-16 59.9 0.0 0.015 16.1 0.0 7.5 5 2 3 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC40880.1 - 3.9e-14 53.0 0.0 6.1e-05 23.6 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40880.1 - 3.8e-12 46.5 0.4 7.3e-05 23.2 0.1 5.4 4 2 2 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40880.1 - 4e-12 45.3 3.0 0.0021 18.0 0.0 5.5 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFC40880.1 - 3.2e-11 43.0 0.7 8.3e-05 21.9 0.0 3.8 2 1 2 4 4 4 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC40880.1 - 7.8e-10 38.0 2.7 0.028 13.8 0.1 5.3 7 0 0 7 7 6 3 SHNi-TPR TPR_6 PF13174.6 EFC40880.1 - 9e-10 38.6 0.7 0.39 11.5 0.0 5.9 6 0 0 6 6 5 1 Tetratricopeptide repeat FAT PF02259.23 EFC40880.1 - 5.6e-06 25.8 6.4 0.0025 17.1 0.5 3.2 1 1 0 3 3 3 2 FAT domain TPR_10 PF13374.6 EFC40880.1 - 6.7e-06 25.8 1.6 0.62 10.0 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat BTAD PF03704.17 EFC40880.1 - 1.6e-05 25.4 0.0 0.45 11.0 0.0 3.9 2 1 2 4 4 4 2 Bacterial transcriptional activator domain ANAPC3 PF12895.7 EFC40880.1 - 8.4e-05 22.7 1.2 2.1 8.6 0.1 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EFC40880.1 - 0.0003 21.0 0.0 8.7 6.8 0.0 4.3 4 1 1 5 5 4 0 Tetratricopeptide repeat SNAP PF14938.6 EFC40880.1 - 0.00047 19.7 7.2 0.63 9.4 0.2 3.8 2 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 EFC40880.1 - 0.00049 19.6 0.0 0.19 11.1 0.0 3.1 2 1 0 2 2 2 1 MalT-like TPR region NARP1 PF12569.8 EFC40880.1 - 0.00051 19.1 4.4 0.063 12.2 0.1 3.1 2 1 1 3 3 3 2 NMDA receptor-regulated protein 1 DASH_Dad4 PF08650.10 EFC40880.1 - 0.00099 19.0 5.8 0.0012 18.7 0.3 3.4 3 0 0 3 3 3 1 DASH complex subunit Dad4 TPR_3 PF07720.12 EFC40880.1 - 0.0014 18.5 0.1 2.2 8.4 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 EFC40880.1 - 0.003 17.6 2.4 9.8 6.2 0.1 4.4 2 2 1 4 4 4 0 Domain of Unknown Function (DUF3856) Fis1_TPR_C PF14853.6 EFC40880.1 - 0.014 15.5 3.0 8.4 6.6 0.0 4.8 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ANAPC5 PF12862.7 EFC40880.1 - 0.015 15.3 0.6 11 6.1 0.0 3.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 TPR_21 PF09976.9 EFC40880.1 - 0.02 14.6 3.6 0.32 10.7 0.1 3.5 2 1 2 4 4 4 0 Tetratricopeptide repeat-like domain TOM20_plant PF06552.12 EFC40880.1 - 0.046 13.5 4.6 1.2 8.9 0.3 4.1 2 2 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 MIT PF04212.18 EFC40880.1 - 0.061 13.4 8.4 12 6.0 0.1 6.4 4 2 3 7 7 7 0 MIT (microtubule interacting and transport) domain DUF3232 PF11554.8 EFC40880.1 - 0.17 12.3 2.4 1.4 9.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3232) Rep_3 PF01051.21 EFC40880.1 - 0.28 11.0 7.2 2.7 7.7 1.3 2.4 2 0 0 2 2 2 0 Initiator Replication protein Cytochrom_C_2 PF01322.20 EFC40880.1 - 0.58 11.1 2.0 59 4.6 0.0 3.8 4 1 1 5 5 3 0 Cytochrome C' DNA_primase_lrg PF04104.14 EFC40880.1 - 4.3 6.7 7.3 25 4.2 0.7 3.6 2 1 2 4 4 4 0 Eukaryotic and archaeal DNA primase, large subunit DUF829 PF05705.14 EFC40881.1 - 8.4e-28 97.9 3.0 9.4e-22 78.1 0.0 2.5 2 0 0 2 2 2 2 Eukaryotic protein of unknown function (DUF829) IstB_IS21_ATP PF08483.11 EFC40882.1 - 0.18 11.7 0.2 0.39 10.6 0.2 1.5 1 0 0 1 1 1 0 IstB-like ATP binding N-terminal DSPc PF00782.20 EFC40883.1 - 1.4e-25 89.6 0.4 1.7e-25 89.4 0.4 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC40883.1 - 4e-06 27.0 0.0 4.3e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFC40883.1 - 0.00015 21.4 0.2 0.00029 20.5 0.2 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFC40883.1 - 0.0035 17.3 0.0 0.0035 17.3 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family CDKN3 PF05706.12 EFC40883.1 - 0.0036 17.0 0.1 0.0043 16.8 0.1 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Myotub-related PF06602.14 EFC40883.1 - 0.005 15.8 0.0 0.0051 15.8 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase2 PF03162.13 EFC40883.1 - 0.0059 16.2 0.1 0.0072 15.9 0.1 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 EFC40883.1 - 0.0087 16.4 0.0 0.011 16.0 0.0 1.2 1 0 0 1 1 1 1 Rit1 DUSP-like domain DegV PF02645.16 EFC40883.1 - 0.023 14.0 0.0 0.028 13.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 CdvA PF18822.1 EFC40883.1 - 0.064 13.1 0.2 0.093 12.6 0.2 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain E1_dh PF00676.20 EFC40884.1 - 1.9e-109 365.2 0.2 2.6e-109 364.8 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 EFC40884.1 - 0.0044 16.3 0.0 0.0087 15.3 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PE-PPE PF08237.11 EFC40884.1 - 0.05 13.2 0.0 0.092 12.3 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain P22_AR_C PF10548.9 EFC40884.1 - 0.12 12.5 0.3 0.66 10.2 0.0 2.3 3 0 0 3 3 3 0 P22AR C-terminal domain EGF_2 PF07974.13 EFC40885.1 - 4.3e-06 27.0 34.3 0.0061 16.9 6.5 4.4 4 0 0 4 4 4 3 EGF-like domain TRP PF06011.12 EFC40885.1 - 0.049 12.4 5.9 0.12 11.1 5.9 1.5 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel EGF PF00008.27 EFC40885.1 - 3.2 8.2 15.4 22 5.5 1.9 3.9 3 0 0 3 3 3 0 EGF-like domain Maf PF02545.14 EFC40887.1 - 7.8e-51 172.2 0.0 8.8e-51 172.0 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein BTB PF00651.31 EFC40888.1 - 9.8e-10 38.6 2.5 2.9e-09 37.1 0.2 3.0 3 0 0 3 3 3 1 BTB/POZ domain Phage_int_SAM_6 PF18644.1 EFC40888.1 - 0.022 14.8 0.5 0.16 12.0 0.1 2.7 2 0 0 2 2 2 0 Phage integrase SAM-like domain Arm PF00514.23 EFC40888.1 - 0.097 12.8 0.3 3.5 7.8 0.0 3.4 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat F-box-like PF12937.7 EFC40889.1 - 3.7e-05 23.5 0.2 5.6e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EFC40889.1 - 0.0042 17.4 0.8 0.13 12.6 0.0 2.8 2 1 1 3 3 3 1 PRANC domain F-box PF00646.33 EFC40889.1 - 0.0094 15.8 0.1 0.02 14.8 0.1 1.5 1 0 0 1 1 1 1 F-box domain DUF4709 PF15821.5 EFC40889.1 - 0.017 15.4 0.1 0.017 15.4 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4709) Mitofilin PF09731.9 EFC40889.1 - 0.44 9.3 7.7 0.54 9.0 7.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Laminin_II PF06009.12 EFC40889.1 - 0.51 10.4 7.3 1 9.4 2.7 2.6 1 1 2 3 3 3 0 Laminin Domain II BLOC1_2 PF10046.9 EFC40889.1 - 1.9 8.9 12.7 4.3 7.7 0.9 3.1 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin PF02996.17 EFC40889.1 - 4.2 7.3 12.1 1.4 8.8 1.3 2.8 2 1 1 3 3 3 0 Prefoldin subunit ABC1 PF03109.16 EFC40890.1 - 1.1e-33 115.9 3.3 1.7e-33 115.3 0.2 2.7 3 0 0 3 3 3 1 ABC1 family RIO1 PF01163.22 EFC40890.1 - 0.013 15.1 6.5 0.032 13.8 0.1 3.9 4 0 0 4 4 4 0 RIO1 family DUF4175 PF13779.6 EFC40890.1 - 0.02 12.9 0.3 0.029 12.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) GrpE PF01025.19 EFC40890.1 - 0.03 14.0 1.5 0.13 11.9 1.5 2.1 1 0 0 1 1 1 0 GrpE KilA-N PF04383.13 EFC40890.1 - 0.054 13.4 0.2 0.2 11.5 0.2 2.1 1 0 0 1 1 1 0 KilA-N domain FTO_CTD PF12934.7 EFC40890.1 - 0.16 11.7 1.9 10 5.9 0.1 2.5 2 0 0 2 2 2 0 FTO C-terminal domain DUF1002 PF06207.11 EFC40890.1 - 0.65 9.5 4.5 1.1 8.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1002) TIP120 PF08623.10 EFC40891.1 - 4e-48 163.4 0.2 4e-48 163.4 0.2 6.6 5 3 3 8 8 8 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 EFC40891.1 - 8.2e-13 48.6 4.0 0.59 10.6 0.2 7.9 6 1 1 7 7 7 4 HEAT repeats HEAT PF02985.22 EFC40891.1 - 8.6e-11 41.1 16.6 0.074 13.3 0.1 10.8 13 0 0 13 13 11 2 HEAT repeat HEAT_EZ PF13513.6 EFC40891.1 - 5.8e-10 39.5 6.3 1.2 9.7 0.0 9.7 8 1 2 10 10 10 2 HEAT-like repeat MMS19_C PF12460.8 EFC40891.1 - 1.1e-06 28.0 29.1 0.00036 19.8 0.2 6.7 6 2 1 7 7 7 4 RNAPII transcription regulator C-terminal UME PF08064.13 EFC40891.1 - 2.8e-06 27.2 5.1 0.00052 19.9 0.1 5.2 4 2 1 5 5 5 1 UME (NUC010) domain DUF3385 PF11865.8 EFC40891.1 - 0.0035 17.2 11.5 1.2 9.1 0.0 6.1 5 2 1 6 6 6 1 Domain of unknown function (DUF3385) Cnd3 PF12719.7 EFC40891.1 - 0.0064 15.7 0.1 0.0064 15.7 0.1 5.6 5 3 2 7 7 7 1 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 EFC40891.1 - 0.024 14.7 21.9 0.16 12.0 0.9 7.0 6 1 1 7 7 7 0 non-SMC mitotic condensation complex subunit 1 ParcG PF10274.9 EFC40891.1 - 0.031 14.4 10.5 1.6 8.8 0.0 5.7 6 1 0 6 6 6 0 Parkin co-regulated protein TAF6_C PF07571.13 EFC40891.1 - 0.035 14.4 1.3 17 5.8 0.0 5.3 6 1 0 6 6 6 0 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 EFC40891.1 - 0.093 12.9 1.9 1.8 8.8 0.2 3.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 EFC40891.1 - 0.16 11.5 15.6 2.3 7.7 0.1 6.2 4 2 4 9 9 9 0 Dos2-interacting transcription regulator of RNA-Pol-II Baculo_PEP_C PF04513.12 EFC40891.1 - 1.5 8.9 9.0 0.82 9.7 1.4 4.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Arm PF00514.23 EFC40891.1 - 7.7 6.7 8.2 12 6.0 0.1 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Kelch_3 PF13415.6 EFC40892.1 - 2.9e-18 65.7 1.3 0.0043 17.3 0.0 5.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC40892.1 - 1.2e-16 60.4 7.4 0.00056 19.9 0.0 6.1 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC40892.1 - 3.1e-14 52.6 2.3 0.012 15.9 0.0 5.4 6 0 0 6 6 6 4 Kelch motif Kelch_5 PF13854.6 EFC40892.1 - 2e-08 34.0 11.2 0.024 14.6 0.0 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 EFC40892.1 - 6.9e-08 32.2 10.1 0.067 13.2 0.3 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 EFC40892.1 - 1.4e-07 31.0 8.6 0.054 13.1 0.2 5.5 6 1 0 6 6 6 2 Kelch motif F-box-like PF12937.7 EFC40892.1 - 0.003 17.4 0.1 0.0073 16.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like HEPN_LA2681 PF18733.1 EFC40892.1 - 0.066 12.5 0.2 0.11 11.8 0.2 1.3 1 0 0 1 1 1 0 LA2681-like HEPN Lpp-LpqN PF10738.9 EFC40892.1 - 0.11 11.9 0.0 0.94 8.9 0.0 2.0 2 0 0 2 2 2 0 Probable lipoprotein LpqN COMM_domain PF07258.14 EFC40894.1 - 1.5e-16 60.3 3.0 4.1e-16 58.9 1.5 2.2 2 0 0 2 2 2 1 COMM domain LCIB_C_CA PF18599.1 EFC40895.1 - 0.18 11.0 1.6 4.9 6.4 0.1 2.8 3 0 0 3 3 3 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases HMMR_N PF15905.5 EFC40895.1 - 1.9 7.9 11.9 0.041 13.4 5.4 1.6 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal F-box-like PF12937.7 EFC40896.1 - 0.00048 20.0 0.0 0.002 18.0 0.0 2.1 1 0 0 1 1 1 1 F-box-like F-box-like PF12937.7 EFC40897.1 - 3.2e-05 23.7 0.5 3.2e-05 23.7 0.5 2.3 2 0 0 2 2 2 1 F-box-like KH_1 PF00013.29 EFC40897.1 - 9.5e-05 22.1 0.0 0.0003 20.6 0.0 1.8 1 0 0 1 1 1 1 KH domain Guanylate_cyc PF00211.20 EFC40898.1 - 4.7e-34 117.6 0.1 9.5e-34 116.6 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40898.1 - 6e-15 55.4 1.6 1.1e-14 54.5 0.4 2.1 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC40898.1 - 7e-08 32.5 0.0 1.7e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC40898.1 - 0.00032 20.6 0.0 0.001 19.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain HNOBA PF07701.14 EFC40898.1 - 0.04 13.4 0.1 0.099 12.1 0.1 1.7 1 0 0 1 1 1 0 Heme NO binding associated DUF5532 PF17673.1 EFC40899.1 - 0.014 15.4 0.1 0.42 10.7 0.0 2.9 3 1 0 3 3 3 0 Family of unknown function (DUF5532) SANT_DAMP1_like PF16282.5 EFC40899.1 - 0.014 15.6 0.2 0.04 14.1 0.2 1.9 1 1 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Pkinase PF00069.25 EFC40902.1 - 4.7e-40 137.6 0.1 8.6e-40 136.8 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40902.1 - 1.5e-38 132.6 0.0 3.7e-38 131.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC40902.1 - 5.1e-11 43.0 0.2 1.2e-10 41.8 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC40902.1 - 1.7e-09 37.7 0.1 1.3e-08 34.9 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC40902.1 - 2.4e-06 28.0 0.2 0.0017 18.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC40902.1 - 3.5e-06 26.9 0.0 8.8e-05 22.6 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFC40902.1 - 4e-06 27.0 0.1 2.3e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeat Zmiz1_N PF18028.1 EFC40902.1 - 0.052 13.9 0.1 0.15 12.4 0.1 1.8 1 0 0 1 1 1 0 Zmiz1 N-terminal tetratricopeptide repeat domain DUF2867 PF11066.8 EFC40903.1 - 0.0057 17.0 0.0 0.0077 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2867) ERG2_Sigma1R PF04622.12 EFC40903.1 - 0.049 13.0 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 ERG2 and Sigma1 receptor like protein Mito_carr PF00153.27 EFC40904.1 - 2.2e-52 174.9 2.6 9.8e-20 70.3 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 EFC40904.1 - 2.8e-19 67.1 5.4 4.4e-06 25.9 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC40904.1 - 6.9e-16 58.5 8.3 6e-10 39.4 0.5 3.3 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC40904.1 - 1.6e-15 55.6 2.5 0.00075 19.2 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFC40904.1 - 4.6e-13 48.0 1.8 0.0023 17.3 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFC40904.1 - 1.5e-12 47.1 7.1 9.7e-07 28.6 0.3 3.5 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 EFC40904.1 - 0.0011 18.9 0.6 0.11 12.5 0.1 2.8 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC40904.1 - 0.029 14.7 2.4 0.19 12.1 2.4 2.4 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region GPS2_interact PF15784.5 EFC40905.1 - 0.0065 16.9 0.2 0.018 15.4 0.2 1.8 1 0 0 1 1 1 1 G-protein pathway suppressor 2-interacting domain Na_Ca_ex_C PF16494.5 EFC40905.1 - 0.13 12.7 0.6 0.34 11.4 0.6 1.7 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain Guanylate_cyc PF00211.20 EFC40908.1 - 1e-50 171.9 0.1 2.2e-50 170.8 0.1 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC40908.1 - 8.6e-17 61.3 0.3 2.4e-16 59.8 0.3 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC40908.1 - 0.00054 19.9 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC40908.1 - 0.0015 18.0 0.4 0.0041 16.6 0.4 1.7 1 0 0 1 1 1 1 Heme NO binding associated UPF0158 PF03682.13 EFC40908.1 - 0.045 13.7 1.2 14 5.7 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0158) PAS_4 PF08448.10 EFC40908.1 - 0.19 12.0 0.0 0.38 11.0 0.0 1.5 1 0 0 1 1 1 0 PAS fold MWFE PF15879.5 EFC40908.1 - 0.23 11.7 1.1 0.92 9.7 0.0 2.6 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit AAA_22 PF13401.6 EFC40911.1 - 3.7e-06 27.3 0.0 1.3e-05 25.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFC40911.1 - 0.00054 20.0 2.6 0.00091 19.3 0.2 2.6 3 0 0 3 3 3 1 AAA domain DUF2075 PF09848.9 EFC40911.1 - 0.001 18.4 0.0 0.014 14.6 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EFC40911.1 - 0.034 14.5 0.0 0.26 11.7 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain DUF1128 PF06569.11 EFC40911.1 - 0.093 12.7 1.5 0.41 10.7 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) Pox_polyA_pol PF03296.13 EFC40911.1 - 0.47 10.3 10.3 1.5 8.7 0.2 3.5 2 1 0 3 3 3 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain p450 PF00067.22 EFC40912.1 - 1.2e-62 212.2 6.3 1.7e-62 211.7 6.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 PfkB PF00294.24 EFC40913.1 - 3.3e-07 29.9 0.0 0.00013 21.4 0.0 2.7 2 1 0 2 2 2 2 pfkB family carbohydrate kinase RGS PF00615.19 EFC40914.1 - 4.1e-05 23.8 8.6 0.0001 22.6 8.6 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Methyltransf_11 PF08241.12 EFC40915.1 - 2.2e-17 63.5 0.0 3.9e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC40915.1 - 1.2e-16 61.2 0.0 2.4e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC40915.1 - 8.3e-15 55.3 0.0 1.4e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC40915.1 - 1.4e-14 54.1 0.0 1.8e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC40915.1 - 8.8e-14 51.4 0.0 1.4e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC40915.1 - 6.4e-09 35.9 0.0 8.3e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 EFC40915.1 - 0.00029 20.5 0.0 0.00042 20.0 0.0 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) N2227 PF07942.12 EFC40915.1 - 0.028 13.6 0.0 0.036 13.3 0.0 1.1 1 0 0 1 1 1 0 N2227-like protein TPR_11 PF13414.6 EFC40918.1 - 3.3e-11 42.7 0.1 7e-05 22.4 0.0 2.6 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.17 EFC40918.1 - 3.2e-09 36.2 0.0 0.0069 16.4 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC40918.1 - 1.8e-07 31.7 0.0 0.0053 17.4 0.0 2.4 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC40918.1 - 2.3e-07 31.1 0.0 0.002 18.8 0.0 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40918.1 - 6.1e-07 29.2 0.1 1.1 9.6 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40918.1 - 3.6e-06 27.0 0.6 0.0025 18.1 0.0 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40918.1 - 0.00013 21.7 1.6 3 7.8 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC40918.1 - 0.002 18.6 0.0 0.12 13.1 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TOM20_plant PF06552.12 EFC40918.1 - 0.0051 16.6 0.2 1.9 8.2 0.0 2.1 1 1 1 2 2 2 2 Plant specific mitochondrial import receptor subunit TOM20 ChAPs PF09295.10 EFC40918.1 - 0.096 11.7 0.0 0.096 11.7 0.0 1.1 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_7 PF13176.6 EFC40918.1 - 0.12 12.4 0.1 2.3 8.4 0.0 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40918.1 - 0.15 12.6 0.1 7.2 7.2 0.0 2.5 2 1 1 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 EFC40921.1 - 4.3e-11 43.2 3.8 2.7e-06 28.0 0.0 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC40921.1 - 0.00062 20.0 0.0 0.061 13.6 0.0 2.5 1 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain TRPM_tetra PF16519.5 EFC40921.1 - 0.11 12.7 1.3 1.9 8.7 0.0 2.9 3 0 0 3 3 3 0 Tetramerisation domain of TRPM EF-hand_7 PF13499.6 EFC40923.1 - 4.5e-23 81.5 8.2 4.6e-10 39.8 0.9 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC40923.1 - 1.9e-18 64.8 8.1 1.2e-06 28.0 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 EFC40923.1 - 2.4e-18 64.2 13.0 7e-08 31.5 0.8 4.3 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 EFC40923.1 - 8.9e-12 43.9 14.2 3.9e-06 26.1 1.1 3.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFC40923.1 - 6.9e-09 35.4 8.8 8.2e-05 22.4 2.4 3.7 3 1 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC40923.1 - 5.8e-05 23.4 0.6 0.14 12.5 0.2 2.8 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC40923.1 - 0.091 12.7 2.0 2.1 8.3 0.4 3.0 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 EFC40923.1 - 0.12 12.5 0.2 0.12 12.5 0.2 2.7 2 1 2 4 4 4 0 p25-alpha WD40 PF00400.32 EFC40924.1 - 6.2e-20 71.2 10.2 2.1e-05 25.2 0.2 7.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC40924.1 - 2.4e-15 56.6 0.1 0.009 16.3 0.0 7.2 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain ArlS_N PF18719.1 EFC40924.1 - 2.3e-05 24.6 0.1 0.071 13.3 0.0 3.3 3 0 0 3 3 2 2 ArlS sensor domain Clathrin PF00637.20 EFC40924.1 - 6.1e-05 22.9 15.9 0.05 13.5 1.1 5.0 1 1 4 6 6 6 3 Region in Clathrin and VPS Nic96 PF04097.14 EFC40924.1 - 0.00054 18.5 0.4 0.00054 18.5 0.4 2.6 2 1 1 3 3 3 1 Nup93/Nic96 WD40_3 PF15911.5 EFC40924.1 - 0.0077 16.2 0.0 0.094 12.7 0.0 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat TPR_7 PF13176.6 EFC40924.1 - 0.032 14.3 0.8 24 5.2 0.1 4.8 4 2 0 4 4 4 0 Tetratricopeptide repeat RAB3GAP2_N PF14655.6 EFC40924.1 - 0.061 12.6 0.1 1.1 8.5 0.0 2.8 3 1 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PPR PF01535.20 EFC40924.1 - 0.063 13.6 8.1 64 4.1 0.0 5.9 5 1 1 6 6 5 0 PPR repeat TagA PF12561.8 EFC40924.1 - 0.17 12.3 0.8 0.58 10.6 0.2 2.3 2 0 0 2 2 1 0 ToxR activated gene A lipoprotein domain ANAPC3 PF12895.7 EFC40924.1 - 0.62 10.3 11.2 15 5.9 0.8 5.4 2 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFC40924.1 - 0.87 10.6 5.8 72 4.6 0.1 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC40924.1 - 2.5 8.5 6.1 33 4.8 0.1 4.4 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC40924.1 - 3.7 8.4 12.5 40 5.2 0.3 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC40924.1 - 7 7.2 10.3 7.7 7.1 0.2 4.5 5 1 1 6 6 5 0 Tetratricopeptide repeat Methyltransf_25 PF13649.6 EFC40925.1 - 4.4e-14 52.9 0.0 1.8e-13 51.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC40925.1 - 1.8e-12 47.7 0.0 5.3e-12 46.2 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC40925.1 - 2.6e-12 46.8 0.0 3.8e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC40925.1 - 4.8e-09 36.3 0.0 8.2e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFC40925.1 - 9.2e-09 35.1 0.0 1.4e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 EFC40925.1 - 1.9e-05 25.3 0.0 4.1e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFC40925.1 - 5e-05 22.4 0.0 8.3e-05 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 EFC40925.1 - 9.7e-05 21.8 0.0 0.00015 21.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 EFC40925.1 - 0.0003 20.4 0.1 0.00051 19.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 EFC40925.1 - 0.00089 18.7 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 EFC40925.1 - 0.0014 18.6 0.1 0.0028 17.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 EFC40925.1 - 0.0052 16.2 0.1 0.014 14.8 0.1 1.7 1 1 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 EFC40925.1 - 0.011 15.5 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 EFC40925.1 - 0.019 15.9 0.0 0.069 14.2 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.19 EFC40925.1 - 0.045 13.9 0.1 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 FtsJ-like methyltransferase PCMT PF01135.19 EFC40925.1 - 0.073 12.8 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PRMT5_C PF17286.2 EFC40925.1 - 0.087 12.7 0.1 0.14 12.0 0.1 1.3 1 0 0 1 1 1 0 PRMT5 oligomerisation domain Methyltransf_4 PF02390.17 EFC40925.1 - 0.095 12.2 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Putative methyltransferase DOT1 PF08123.13 EFC40925.1 - 0.1 12.1 0.0 0.27 10.7 0.0 1.7 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 EFC40925.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain ChaC PF04752.12 EFC40926.1 - 2.9e-38 131.7 0.0 4.4e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 ChaC-like protein PUA PF01472.20 EFC40926.1 - 3.7e-14 52.4 0.0 6.8e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 PUA domain AIG2_2 PF13772.6 EFC40926.1 - 0.002 18.4 0.2 0.0097 16.3 0.2 2.2 1 1 0 1 1 1 1 AIG2-like family Deltaretro_Tax PF05599.11 EFC40926.1 - 0.08 13.5 0.1 0.16 12.5 0.1 1.4 1 0 0 1 1 1 0 Deltaretrovirus Tax protein Mre11_DNA_bind PF04152.14 EFC40927.1 - 1.9e-37 129.2 1.4 1.9e-37 129.2 1.4 4.9 2 2 1 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 EFC40927.1 - 8.4e-12 46.0 2.2 2.2e-11 44.7 2.2 1.8 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC40927.1 - 0.00067 19.9 0.0 0.005 17.0 0.0 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ac76 PF05814.11 EFC40927.1 - 1.8 8.6 4.4 8.2 6.5 4.4 2.2 1 0 0 1 1 1 0 Orf76 (Ac76) CdiI_2 PF18593.1 EFC40927.1 - 3.1 8.5 6.4 3.7 8.3 0.9 3.0 2 0 0 2 2 2 0 CdiI immunity protein FragX_IP PF05994.11 EFC40928.1 - 1.1e-234 781.3 22.6 1.1e-234 781.3 22.6 3.0 2 1 1 3 3 3 1 Cytoplasmic Fragile-X interacting family Drf_FH1 PF06346.12 EFC40928.1 - 0.00023 20.9 42.8 0.00036 20.3 42.8 1.2 1 0 0 1 1 1 1 Formin Homology Region 1 Acyltransferase PF01553.21 EFC40929.1 - 0.0013 18.3 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase TraI_2 PF07514.11 EFC40929.1 - 0.042 12.8 0.0 1.6 7.6 0.0 2.1 2 0 0 2 2 2 0 Putative helicase Pkinase PF00069.25 EFC40930.1 - 8.6e-64 215.4 0.8 1.1e-63 215.1 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40930.1 - 2.1e-45 155.0 0.0 3.2e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC40930.1 - 0.00079 18.3 0.0 0.0013 17.6 0.0 1.5 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC40930.1 - 0.00081 18.4 0.7 0.0099 14.8 0.7 2.3 1 1 0 1 1 1 1 Haspin like kinase domain Nop14 PF04147.12 EFC40930.1 - 0.05 11.8 15.7 0.066 11.4 15.7 1.1 1 0 0 1 1 1 0 Nop14-like family Kinase-like PF14531.6 EFC40930.1 - 0.051 12.9 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Kinase-like Coatomer_g_Cpla PF16381.5 EFC40930.1 - 0.1 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Coatomer subunit gamma-1 C-terminal appendage platform PBP1_TM PF14812.6 EFC40930.1 - 4.1 7.9 20.5 5.9 7.3 8.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LRR_6 PF13516.6 EFC40931.1 - 5.2 7.4 8.5 21 5.5 0.4 4.7 4 0 0 4 4 4 0 Leucine Rich repeat FNIP PF05725.12 EFC40931.1 - 8.9 6.6 12.3 15 5.9 0.5 5.2 5 0 0 5 5 5 0 FNIP Repeat MMR_HSR1 PF01926.23 EFC40932.1 - 2.2e-17 63.2 0.0 1.6e-15 57.2 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC40932.1 - 7.3e-09 35.3 0.1 7.2e-08 32.1 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC40932.1 - 1e-07 32.1 0.1 5.3e-05 23.2 0.0 2.7 2 1 1 3 3 3 2 RsgA GTPase AIG1 PF04548.16 EFC40932.1 - 0.00065 19.1 0.6 0.0021 17.4 0.1 2.1 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 EFC40932.1 - 0.0031 17.6 1.7 0.0031 17.6 1.7 4.4 3 3 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 EFC40932.1 - 0.0061 16.1 2.2 6.8 6.2 0.1 3.6 2 2 0 2 2 2 2 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC40932.1 - 0.0061 16.0 6.4 0.14 11.6 0.1 2.8 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC40932.1 - 0.17 12.1 3.2 0.55 10.5 0.1 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFC40932.1 - 0.61 9.8 2.6 0.79 9.5 0.0 2.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Sdh_cyt PF01127.22 EFC40933.1 - 0.0002 21.4 1.5 0.0014 18.7 0.0 2.1 1 1 1 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1691 PF07950.11 EFC40933.1 - 0.00028 21.6 0.5 0.048 14.4 0.2 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF1691) DUF21 PF01595.20 EFC40934.1 - 4.2e-28 98.2 0.7 4.2e-28 98.2 0.7 1.9 2 0 0 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 EFC40934.1 - 2.4e-08 34.3 0.2 0.0016 18.8 0.0 2.6 2 0 0 2 2 2 2 CBS domain cNMP_binding PF00027.29 EFC40934.1 - 5.6e-06 26.3 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain PA28_beta PF02252.18 EFC40935.1 - 0.057 13.1 0.2 0.2 11.3 0.1 1.8 1 1 1 2 2 2 0 Proteasome activator pa28 beta subunit P5-ATPase PF12409.8 EFC40935.1 - 0.34 11.0 2.6 0.82 9.8 1.9 2.0 1 1 0 2 2 2 0 P5-type ATPase cation transporter DUF4366 PF14283.6 EFC40935.1 - 3.2 7.8 5.2 68 3.5 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4366) USP8_dimer PF08969.11 EFC40937.1 - 1.2e-12 48.0 4.3 1.2e-12 48.0 4.3 2.0 2 0 0 2 2 2 1 USP8 dimerisation domain DUF2254 PF10011.9 EFC40937.1 - 0.057 12.2 1.0 0.089 11.6 1.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF4214 PF13946.6 EFC40937.1 - 0.64 10.1 3.5 0.34 11.0 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4214) ATC_hydrolase PF14196.6 EFC40937.1 - 0.95 10.2 4.8 0.66 10.7 0.3 2.5 3 0 0 3 3 3 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase Abhydrolase_3 PF07859.13 EFC40938.1 - 3.4e-15 56.5 0.0 4.5e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 EFC40938.1 - 9.2e-05 22.1 0.0 0.00015 21.5 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 EFC40938.1 - 0.0015 18.4 0.0 0.0028 17.5 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 EFC40938.1 - 0.0036 17.9 0.0 0.005 17.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 EFC40938.1 - 0.027 14.6 0.0 0.048 13.8 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 EFC40938.1 - 0.045 13.0 0.1 0.37 10.0 0.0 2.4 2 1 1 3 3 3 0 Serine aminopeptidase, S33 DUF1749 PF08538.10 EFC40938.1 - 0.11 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Cutinase PF01083.22 EFC40938.1 - 0.19 11.7 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Cutinase Sel1 PF08238.12 EFC40939.1 - 6.7e-09 36.1 0.1 4.1e-06 27.3 0.2 2.4 2 0 0 2 2 2 2 Sel1 repeat TPR_6 PF13174.6 EFC40939.1 - 0.11 13.2 0.2 5.7 7.8 0.1 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40939.1 - 0.39 11.1 6.3 18 5.8 0.7 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Glyco_hydro_38N PF01074.22 EFC40940.1 - 4e-79 266.0 3.0 7.1e-79 265.2 3.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFC40940.1 - 7.8e-23 81.7 0.5 1.4e-22 80.8 0.5 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFC40940.1 - 2.4e-16 59.7 0.1 5.8e-16 58.4 0.1 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain ECSCR PF15820.5 EFC40940.1 - 0.0026 17.6 2.4 1.5 8.7 0.4 2.6 2 0 0 2 2 2 2 Endothelial cell-specific chemotaxis regulator FbpA PF05833.11 EFC40940.1 - 0.0053 15.6 0.3 0.011 14.6 0.3 1.4 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Glyco_hydro38C2 PF17677.1 EFC40940.1 - 0.068 13.3 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain TMEM51 PF15345.6 EFC40941.1 - 0.039 13.8 0.2 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 SH3_5 PF08460.10 EFC40941.1 - 0.11 12.6 0.8 0.28 11.3 0.8 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain DUF4834 PF16118.5 EFC40941.1 - 0.25 12.3 0.2 0.25 12.3 0.2 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) Syntaxin PF00804.25 EFC40942.1 - 0.00094 18.9 0.0 0.0019 17.9 0.0 1.4 1 0 0 1 1 1 1 Syntaxin Fic PF02661.18 EFC40943.1 - 5.9e-21 75.2 0.0 1.2e-20 74.2 0.0 1.4 1 0 0 1 1 1 1 Fic/DOC family PI3Ka PF00613.20 EFC40945.1 - 2.2e-18 66.3 2.3 5.4e-18 65.1 2.3 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EFC40945.1 - 2.1e-07 31.0 0.1 3.9e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 LRR_4 PF12799.7 EFC40945.1 - 0.015 15.7 2.4 0.14 12.7 1.0 3.1 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC40945.1 - 0.19 12.4 1.0 8 7.5 0.1 3.5 2 0 0 2 2 2 0 Leucine Rich Repeat F-box-like PF12937.7 EFC40946.1 - 7.3e-07 29.0 0.1 2.6e-06 27.2 0.1 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC40946.1 - 0.00014 21.6 0.1 0.00058 19.7 0.0 2.1 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 EFC40946.1 - 0.09 12.9 1.9 0.96 9.7 0.0 2.8 4 0 0 4 4 4 0 Leucine Rich repeat Synaptobrevin PF00957.21 EFC40947.1 - 1.9e-16 59.6 9.6 1.9e-16 59.6 9.6 1.8 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 EFC40947.1 - 7.6e-05 22.7 0.4 0.00019 21.4 0.4 1.7 1 0 0 1 1 1 1 Regulated-SNARE-like domain CEP44 PF15007.6 EFC40947.1 - 0.025 14.7 2.1 0.041 14.0 1.7 1.6 1 1 0 1 1 1 0 Centrosomal spindle body, CEP44 Amnionless PF14828.6 EFC40947.1 - 0.089 11.6 4.2 0.26 10.1 0.7 2.0 2 0 0 2 2 2 0 Amnionless Orf78 PF06024.12 EFC40947.1 - 0.15 12.3 2.9 0.45 10.9 2.9 1.8 1 0 0 1 1 1 0 Orf78 (ac78) Pex24p PF06398.11 EFC40947.1 - 0.89 8.5 8.3 0.17 10.8 2.2 1.9 1 1 2 3 3 3 0 Integral peroxisomal membrane peroxin IL3Ra_N PF18611.1 EFC40948.1 - 0.041 13.9 1.1 0.2 11.6 1.1 2.3 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain HAUS6_N PF14661.6 EFC40949.1 - 0.054 13.1 8.9 0.068 12.7 2.3 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus YabA PF06156.13 EFC40949.1 - 0.32 11.6 7.1 0.21 12.2 4.8 1.7 1 1 1 2 2 2 0 Initiation control protein YabA Thioredoxin_4 PF13462.6 EFC40949.1 - 1.4 9.0 6.2 7 6.8 6.2 1.9 1 1 0 1 1 1 0 Thioredoxin Exonuc_VII_L PF02601.15 EFC40949.1 - 7.7 6.0 7.1 8.9 5.8 7.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NTP_transferase PF00483.23 EFC40950.1 - 1.6e-14 54.1 0.0 2.7e-14 53.3 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 EFC40950.1 - 2.5e-07 31.2 0.0 3.9e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 EFC40950.1 - 1.4e-05 24.6 6.1 0.013 15.2 4.6 3.6 2 1 1 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFC40950.1 - 0.0016 18.2 8.8 3.1 7.6 6.6 4.0 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EFC40950.1 - 0.0022 16.2 2.0 0.0022 16.2 2.0 1.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4954) pKID PF02173.17 EFC40950.1 - 0.013 14.9 0.4 0.03 13.8 0.4 1.6 1 0 0 1 1 1 0 pKID domain F-box PF00646.33 EFC40951.1 - 0.0026 17.6 2.1 0.0029 17.4 0.1 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC40951.1 - 0.058 13.3 0.2 0.15 11.9 0.2 1.8 1 0 0 1 1 1 0 F-box-like MIEAP PF16026.5 EFC40951.1 - 1.6 8.9 5.5 1.2 9.3 0.9 2.8 2 0 0 2 2 2 0 Mitochondria-eating protein REJ PF02010.15 EFC40952.1 - 9.9e-17 60.9 19.4 1.4e-15 57.1 11.3 2.3 1 1 0 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC40952.1 - 2.1e-06 28.0 43.1 0.00024 21.4 8.4 4.6 3 1 1 4 4 4 3 EGF-like domain EGF PF00008.27 EFC40952.1 - 8.7 6.8 22.8 0.58 10.5 2.8 4.1 3 0 0 3 3 3 0 EGF-like domain N_BRCA1_IG PF16158.5 EFC40953.1 - 1.1e-14 54.9 0.1 1e-13 51.8 0.0 2.6 3 0 0 3 3 3 1 Ig-like domain from next to BRCA1 gene Adaptin_binding PF10199.9 EFC40953.1 - 0.024 15.2 0.0 0.1 13.2 0.0 2.0 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 FAM199X PF15814.5 EFC40953.1 - 1.8 7.5 6.9 0.2 10.7 1.4 1.9 2 0 0 2 2 2 0 Protein family FAM199X E_Pc_C PF06752.12 EFC40953.1 - 4.2 7.4 17.8 2.3 8.3 1.2 2.7 2 1 0 2 2 2 0 Enhancer of Polycomb C-terminus RhoGEF PF00621.20 EFC40954.1 - 3.8e-26 92.5 5.6 3.8e-26 92.5 5.6 2.0 3 0 0 3 3 3 1 RhoGEF domain RRM_1 PF00076.22 EFC40955.1 - 0.048 13.5 0.0 0.073 12.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) API5 PF05918.11 EFC40955.1 - 2.8 6.6 4.0 3.6 6.3 4.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) OTU PF02338.19 EFC40956.1 - 2.7e-05 24.7 0.0 5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFC40956.1 - 0.032 13.7 0.0 0.092 12.2 0.0 1.5 1 1 0 1 1 1 0 Peptidase C65 Otubain Rpp20 PF12328.8 EFC40956.1 - 0.051 13.5 0.1 0.083 12.8 0.1 1.3 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P DUF4834 PF16118.5 EFC40956.1 - 0.14 13.2 0.6 0.18 12.8 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) APC_u15 PF16636.5 EFC40956.1 - 4.1 7.9 7.0 9.7 6.7 7.0 1.6 1 1 0 1 1 1 0 Unstructured region on APC between APC_crr regions 5 and 6 DSPc PF00782.20 EFC40957.1 - 1.6e-20 73.3 1.0 3e-20 72.4 0.2 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EFC40957.1 - 0.041 14.4 0.0 0.23 12.0 0.0 2.3 2 0 0 2 2 2 0 Rhodanese-like domain PTPlike_phytase PF14566.6 EFC40957.1 - 0.13 12.4 0.1 0.45 10.6 0.1 1.9 1 1 0 1 1 1 0 Inositol hexakisphosphate zf-RING_2 PF13639.6 EFC40958.1 - 8.3e-06 26.0 15.5 2.5e-05 24.5 15.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-TRAF PF02176.18 EFC40958.1 - 1.6e-05 25.5 2.5 1.6e-05 25.5 2.5 3.4 3 1 0 3 3 3 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 EFC40958.1 - 3.4e-05 23.6 16.2 4.3e-05 23.3 14.8 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ZapB PF06005.12 EFC40958.1 - 0.00011 22.5 1.4 0.00018 21.9 1.4 1.2 1 0 0 1 1 1 1 Cell division protein ZapB Sina PF03145.16 EFC40958.1 - 0.00019 21.5 1.6 0.00032 20.7 1.6 1.4 1 0 0 1 1 1 1 Seven in absentia protein family bZIP_1 PF00170.21 EFC40958.1 - 0.0015 18.5 5.8 0.0027 17.7 5.8 1.3 1 0 0 1 1 1 1 bZIP transcription factor DivIC PF04977.15 EFC40958.1 - 0.0019 17.9 0.4 0.0031 17.2 0.4 1.2 1 0 0 1 1 1 1 Septum formation initiator FlaC_arch PF05377.11 EFC40958.1 - 0.0023 18.3 4.1 0.0055 17.1 4.1 1.6 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 EFC40958.1 - 0.0048 16.9 0.7 0.0074 16.3 0.7 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-C3HC4 PF00097.25 EFC40958.1 - 0.0052 16.6 16.4 0.015 15.1 16.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) KASH_CCD PF14662.6 EFC40958.1 - 0.0085 15.9 0.4 0.013 15.3 0.4 1.2 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Spc24 PF08286.11 EFC40958.1 - 0.011 15.9 1.2 0.023 15.0 1.2 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 YabA PF06156.13 EFC40958.1 - 0.012 16.2 0.9 0.028 15.0 0.9 1.6 1 0 0 1 1 1 0 Initiation control protein YabA zf-C3HC4_3 PF13920.6 EFC40958.1 - 0.029 14.2 14.9 0.064 13.1 14.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HAP1_N PF04849.13 EFC40958.1 - 0.044 13.0 0.7 0.069 12.3 0.7 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DASH_Spc19 PF08287.11 EFC40958.1 - 0.066 13.1 0.3 0.1 12.5 0.3 1.2 1 0 0 1 1 1 0 Spc19 TPR_MLP1_2 PF07926.12 EFC40958.1 - 0.071 13.2 1.0 0.13 12.3 1.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein JIP_LZII PF16471.5 EFC40958.1 - 0.071 13.3 3.4 0.13 12.5 3.4 1.3 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II HOOK PF05622.12 EFC40958.1 - 0.095 10.8 0.2 0.13 10.4 0.2 1.1 1 0 0 1 1 1 0 HOOK protein DHR10 PF18595.1 EFC40958.1 - 0.1 12.7 4.1 0.16 12.1 4.1 1.2 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain NRBF2 PF08961.10 EFC40958.1 - 0.11 12.2 0.8 0.17 11.5 0.8 1.2 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator HALZ PF02183.18 EFC40958.1 - 0.12 12.6 2.2 0.24 11.7 2.2 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper DUF2205 PF10224.9 EFC40958.1 - 0.13 12.3 0.5 0.26 11.3 0.5 1.4 1 0 0 1 1 1 0 Short coiled-coil protein Herpes_UL6 PF01763.16 EFC40958.1 - 0.13 10.7 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like bZIP_2 PF07716.15 EFC40958.1 - 0.17 12.0 3.1 0.39 10.8 3.1 1.6 1 1 0 1 1 1 0 Basic region leucine zipper DUF2076 PF09849.9 EFC40958.1 - 0.23 11.4 1.9 0.34 10.9 1.9 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF5320 PF17253.2 EFC40958.1 - 0.4 11.8 2.5 0.56 11.3 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) p450 PF00067.22 EFC40959.1 - 6.6e-60 203.2 0.2 9e-60 202.7 0.2 1.2 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_S8 PF00082.22 EFC40960.1 - 9.2e-38 130.2 0.7 3.4e-37 128.3 0.7 2.0 1 1 0 1 1 1 1 Subtilase family MFS_1 PF07690.16 EFC40960.1 - 2.9e-22 79.1 17.7 1.1e-21 77.2 17.3 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Nodulin-like PF06813.13 EFC40960.1 - 3.4e-20 72.6 9.0 3.4e-20 72.6 9.0 2.2 3 0 0 3 3 3 1 Nodulin-like Sugar_tr PF00083.24 EFC40960.1 - 0.00025 20.0 10.3 0.00025 20.0 10.3 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter PepSY_TM PF03929.16 EFC40960.1 - 0.037 13.7 0.0 0.037 13.7 0.0 3.6 4 0 0 4 4 4 0 PepSY-associated TM region NOC3p PF07540.11 EFC40960.1 - 0.067 13.7 0.4 0.39 11.2 0.5 2.2 2 0 0 2 2 2 0 Nucleolar complex-associated protein G6B PF15096.6 EFC40960.1 - 0.15 11.8 0.3 0.43 10.3 0.3 1.8 1 0 0 1 1 1 0 G6B family Pentapeptide PF00805.22 EFC40961.1 - 4.1e-19 67.9 31.4 9.8e-10 37.9 3.8 6.9 6 2 0 7 7 7 4 Pentapeptide repeats (8 copies) TLD PF07534.16 EFC40961.1 - 3.2e-18 66.3 4.2 3.2e-18 66.3 4.2 2.3 2 0 0 2 2 2 1 TLD Pentapeptide_4 PF13599.6 EFC40961.1 - 1.5e-17 63.5 54.2 8.9e-11 41.8 10.5 6.3 3 1 3 6 6 6 4 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC40961.1 - 9.2e-10 38.5 38.6 9.9e-06 25.6 0.8 7.7 5 2 2 7 7 7 4 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC40961.1 - 0.00088 19.6 0.1 0.0039 17.5 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain FERM_M PF00373.18 EFC40962.1 - 0.016 15.6 4.8 0.081 13.3 0.1 3.1 3 0 0 3 3 3 0 FERM central domain DUF4525 PF15027.6 EFC40962.1 - 0.029 14.1 0.9 0.061 13.1 0.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) FTA4 PF13093.6 EFC40962.1 - 0.053 13.4 8.4 0.24 11.3 8.3 2.0 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF3698 PF12479.8 EFC40962.1 - 0.24 12.0 2.8 0.18 12.4 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3698) Med9 PF07544.13 EFC40962.1 - 8.8 6.5 12.1 0.21 11.7 1.1 3.5 4 1 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Synaptobrevin PF00957.21 EFC40963.1 - 4.3e-16 58.5 0.3 7.8e-16 57.7 0.3 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFC40963.1 - 0.038 14.0 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 Regulated-SNARE-like domain GFA PF04828.14 EFC40964.1 - 3.3e-06 27.3 4.6 3.3e-06 27.3 4.6 1.7 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme BBS2_C PF14782.6 EFC40965.1 - 7e-156 519.3 7.4 3e-155 517.3 4.8 2.0 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, C-terminal BBS2_N PF14781.6 EFC40965.1 - 1.3e-34 118.3 0.2 2.2e-33 114.3 0.1 2.6 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal BBS2_Mid PF14783.6 EFC40965.1 - 2e-33 114.7 0.1 3.7e-31 107.3 0.0 3.0 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.6 EFC40965.1 - 3.9e-05 24.2 2.9 0.024 15.2 0.0 3.2 2 0 0 2 2 2 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFC40965.1 - 4e-05 23.7 4.3 0.0049 17.0 0.3 3.2 3 0 0 3 3 3 2 FG-GAP repeat Itfg2 PF15907.5 EFC40965.1 - 0.00067 18.8 0.2 0.15 11.1 0.0 2.8 3 1 0 3 3 3 1 Integrin-alpha FG-GAP repeat-containing protein 2 LRRFIP PF09738.9 EFC40965.1 - 0.072 12.5 9.6 0.021 14.3 1.7 2.2 2 0 0 2 2 2 0 LRRFIP family DHHA1 PF02272.19 EFC40965.1 - 0.11 13.0 1.6 0.23 11.9 0.3 2.2 2 0 0 2 2 2 0 DHHA1 domain FPRL1_inhibitor PF16104.5 EFC40965.1 - 0.15 12.2 2.6 21 5.3 0.1 3.4 3 0 0 3 3 3 0 Formyl peptide receptor-like 1 inhibitory protein APG17 PF04108.12 EFC40965.1 - 0.19 10.8 6.5 0.47 9.5 1.3 2.2 2 0 0 2 2 2 0 Autophagy protein Apg17 WD40 PF00400.32 EFC40965.1 - 0.2 12.6 0.3 15 6.7 0.0 3.5 4 0 0 4 4 4 0 WD domain, G-beta repeat GAT PF03127.14 EFC40965.1 - 1.5 9.1 6.8 3.1 8.2 1.8 2.7 2 0 0 2 2 2 0 GAT domain APG6_N PF17675.1 EFC40965.1 - 7.9 7.0 9.1 1.3 9.5 1.5 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region CK_II_beta PF01214.18 EFC40966.1 - 6.6e-80 267.2 0.0 8.3e-80 266.9 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit CxC5 PF18718.1 EFC40966.1 - 0.021 14.9 0.2 0.037 14.1 0.2 1.4 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases HVSL PF09749.9 EFC40967.1 - 0.011 15.2 0.3 0.019 14.4 0.3 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein FBA_2 PF07735.17 EFC40967.1 - 3.7 7.7 15.3 1.7 8.9 2.0 5.2 4 1 0 4 4 4 0 F-box associated Amino_oxidase PF01593.24 EFC40968.1 - 2.5e-26 93.0 0.4 2.1e-24 86.6 0.4 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC40968.1 - 1e-09 38.5 0.2 3.3e-09 36.8 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC40968.1 - 4.3e-07 29.9 0.5 7.7e-07 29.0 0.5 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFC40968.1 - 0.0002 20.6 0.4 0.00038 19.7 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC40968.1 - 0.00029 20.2 0.0 0.00047 19.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFC40968.1 - 0.0009 18.7 0.2 0.0013 18.2 0.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFC40968.1 - 0.0083 15.4 0.1 0.014 14.7 0.1 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 EFC40968.1 - 0.016 13.9 0.1 0.029 13.1 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein F420_oxidored PF03807.17 EFC40968.1 - 0.089 13.4 0.2 3.5 8.3 0.1 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent GIDA PF01134.22 EFC40968.1 - 0.12 11.5 0.3 0.2 10.7 0.3 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFC40968.1 - 0.13 11.5 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 EFC40968.1 - 0.19 10.9 0.8 0.39 9.9 0.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Tubulin PF00091.25 EFC40969.1 - 1.8e-46 158.8 0.0 3e-46 158.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EFC40969.1 - 2.5e-05 23.7 0.0 0.00014 21.2 0.0 2.0 1 1 1 2 2 2 1 Tubulin like MFS_1 PF07690.16 EFC40970.1 - 5.2e-17 61.8 27.5 2.1e-08 33.5 10.8 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily UNC-93 PF05978.16 EFC40970.1 - 1.8e-11 44.0 11.0 1.8e-11 44.0 11.0 4.7 5 1 0 5 5 5 2 Ion channel regulatory protein UNC-93 TMEM72 PF16054.5 EFC40970.1 - 0.022 14.5 0.5 0.084 12.6 0.4 2.1 2 0 0 2 2 2 0 Transmembrane protein family 72 FAM176 PF14851.6 EFC40970.1 - 0.024 14.3 0.0 0.38 10.4 0.0 2.7 3 0 0 3 3 3 0 FAM176 family HMGL-like PF00682.19 EFC40971.1 - 7.2e-59 199.5 0.0 1e-58 199.0 0.0 1.2 1 0 0 1 1 1 1 HMGL-like RCC1_2 PF13540.6 EFC40972.1 - 7e-05 22.5 5.1 0.0011 18.7 0.3 2.9 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC40972.1 - 0.018 15.7 3.4 0.4 11.3 0.0 3.1 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Serglycin PF04360.12 EFC40972.1 - 0.15 12.0 0.0 17 5.4 0.0 2.2 2 0 0 2 2 2 0 Serglycin DUF3972 PF13118.6 EFC40973.1 - 0.063 13.7 8.9 0.071 13.6 7.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) DUF1515 PF07439.11 EFC40973.1 - 0.25 11.4 1.2 3 7.9 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) BcrAD_BadFG PF01869.20 EFC40975.1 - 8e-30 104.2 0.0 1e-29 103.9 0.0 1.0 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Hydant_A_N PF05378.13 EFC40975.1 - 0.097 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region Pkinase PF00069.25 EFC40976.1 - 1.2e-42 146.1 0.0 2.1e-42 145.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC40976.1 - 6.8e-31 107.5 0.0 2.3e-29 102.5 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase NHL PF01436.21 EFC40976.1 - 6e-27 92.3 5.2 0.00047 20.1 0.1 10.1 10 0 0 10 10 10 6 NHL repeat EGF_2 PF07974.13 EFC40976.1 - 4.2e-14 52.6 46.2 8.3e-05 22.9 13.0 3.7 3 0 0 3 3 3 3 EGF-like domain Arylesterase PF01731.20 EFC40976.1 - 1.2e-05 25.4 5.9 0.26 11.5 0.0 5.8 6 1 1 7 7 7 1 Arylesterase SGL PF08450.12 EFC40976.1 - 3.1e-05 23.7 1.1 0.46 10.0 0.1 4.5 3 2 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Haspin_kinase PF12330.8 EFC40976.1 - 0.0011 18.0 0.0 0.0019 17.2 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC40976.1 - 0.21 11.5 0.0 0.33 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family EGF PF00008.27 EFC40976.1 - 2.4 8.5 31.4 1.8 8.9 3.5 3.7 3 0 0 3 3 3 0 EGF-like domain cEGF PF12662.7 EFC40976.1 - 5.3 7.1 16.0 28 4.8 0.0 4.1 3 0 0 3 3 3 0 Complement Clr-like EGF-like Chorein_N PF12624.7 EFC40977.1 - 2.7e-12 46.8 0.2 2.7e-12 46.8 0.2 3.7 3 0 0 3 3 3 2 N-terminal region of Chorein or VPS13 LRRC37AB_C PF14914.6 EFC40978.1 - 0.031 14.2 0.5 0.06 13.3 0.5 1.4 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Phage_Gp23 PF10669.9 EFC40978.1 - 0.048 14.0 2.9 0.052 13.9 0.5 2.0 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) DUF4446 PF14584.6 EFC40978.1 - 0.048 13.6 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) OAD_gamma PF04277.13 EFC40978.1 - 0.078 13.6 0.3 0.2 12.3 0.1 1.7 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain UL41A PF17591.2 EFC40978.1 - 0.16 12.1 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Herpesvirus UL41A EphA2_TM PF14575.6 EFC40978.1 - 0.16 12.8 0.1 0.31 11.9 0.1 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain G8 PF10162.9 EFC40979.1 - 3.4e-26 91.7 0.1 1.5e-25 89.6 0.1 2.2 1 0 0 1 1 1 1 G8 domain RGM_C PF06534.13 EFC40979.1 - 3e-05 23.6 0.3 7.6e-05 22.3 0.3 1.6 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) C-terminus EGF_2 PF07974.13 EFC40979.1 - 0.0012 19.2 5.9 0.0012 19.2 5.9 6.0 5 1 1 6 6 6 3 EGF-like domain fn3 PF00041.21 EFC40979.1 - 0.017 15.5 0.4 0.073 13.4 0.4 2.1 1 0 0 1 1 1 0 Fibronectin type III domain NHL PF01436.21 EFC40980.1 - 1.7e-36 122.4 0.7 4.6e-08 32.7 0.0 6.3 6 0 0 6 6 6 5 NHL repeat SGL PF08450.12 EFC40980.1 - 4.8e-10 39.4 0.4 0.41 10.2 0.1 4.8 2 2 2 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EFC40980.1 - 1.8e-08 34.2 15.3 5.5e-05 23.1 0.5 5.5 5 0 0 5 5 5 3 Beta-propeller repeat Arylesterase PF01731.20 EFC40980.1 - 2.2e-06 27.8 3.5 0.4 10.9 0.1 5.3 5 0 0 5 5 5 2 Arylesterase Phytase-like PF13449.6 EFC40980.1 - 0.00083 19.4 0.0 5 7.0 0.0 3.6 3 1 0 3 3 3 2 Esterase-like activity of phytase Reg_prop PF07494.11 EFC40980.1 - 0.07 13.4 0.1 17 6.1 0.0 4.4 5 0 0 5 5 5 0 Two component regulator propeller Zn_clus PF00172.18 EFC40981.1 - 1.8e-09 37.6 11.4 3.3e-09 36.7 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain C4 PF01413.19 EFC40981.1 - 0.32 11.4 3.5 1.7 9.1 3.5 2.3 1 0 0 1 1 1 0 C-terminal tandem repeated domain in type 4 procollagen Eapp_C PF10238.9 EFC40981.1 - 2.3 8.3 7.9 0.43 10.7 1.3 2.7 2 0 0 2 2 2 0 E2F-associated phosphoprotein p450 PF00067.22 EFC40982.1 - 1.1e-83 281.5 1.2 1.5e-83 281.1 1.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF4116 PF13475.6 EFC40983.1 - 4.1e-95 311.4 12.2 1.5e-15 56.7 0.0 9.4 6 2 2 9 9 9 9 Domain of unknown function (DUF4116) AfsA PF03756.13 EFC40983.1 - 0.082 12.9 0.0 17 5.4 0.0 2.9 2 1 1 3 3 3 0 A-factor biosynthesis hotdog domain ZYG-11_interact PF05884.12 EFC40983.1 - 0.23 10.9 2.2 0.22 10.9 0.5 1.7 1 1 1 2 2 2 0 Interactor of ZYG-11 RGS PF00615.19 EFC40984.1 - 9.4e-14 51.7 7.0 3.5e-13 49.9 7.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain START PF01852.19 EFC40984.1 - 5.1e-06 26.0 0.0 1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 START domain SDP_N PF12278.8 EFC40984.1 - 0.077 13.1 0.3 0.23 11.6 0.3 1.7 1 0 0 1 1 1 0 Sex determination protein N terminal FRG1 PF06229.12 EFC40986.1 - 5.1e-07 29.6 0.0 0.022 14.5 0.0 3.1 1 1 2 3 3 3 3 FRG1-like domain Fascin PF06268.13 EFC40986.1 - 6.9e-07 29.5 0.0 0.0011 19.1 0.0 2.6 1 1 1 2 2 2 2 Fascin domain EF-hand_6 PF13405.6 EFC40986.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 EFC40986.1 - 0.039 13.8 0.0 0.07 13.0 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_1 PF00036.32 EFC40986.1 - 0.041 13.4 0.0 0.092 12.3 0.0 1.6 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EFC40986.1 - 0.094 13.2 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair SARAF PF06682.12 EFC40987.1 - 0.015 14.9 0.7 0.37 10.4 0.7 2.1 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Trypan_PARP PF05887.11 EFC40988.1 - 1.3e-06 28.4 87.2 1.8e+04 -27.6 87.2 2.9 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TPR_12 PF13424.6 EFC40989.1 - 5.3e-07 29.8 0.0 0.00031 21.0 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC40989.1 - 3.8e-05 23.6 1.4 0.068 13.4 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC40989.1 - 0.00029 20.7 0.0 0.027 14.6 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC40989.1 - 0.0045 16.8 0.0 0.094 12.6 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC40989.1 - 0.0082 16.1 0.8 0.7 10.0 0.0 3.8 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF5483 PF17581.2 EFC40989.1 - 0.012 14.5 1.2 0.012 14.5 1.2 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5483) TPR_10 PF13374.6 EFC40989.1 - 0.014 15.2 0.0 0.081 12.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC40989.1 - 0.15 12.5 0.5 1.2 9.7 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Acetyltransf_9 PF13527.7 EFC40992.1 - 0.002 18.2 0.2 0.012 15.7 0.0 2.2 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC40992.1 - 0.0037 17.5 0.4 0.0096 16.2 0.3 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC40992.1 - 0.0084 16.0 0.2 0.042 13.8 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Spt5-NGN PF03439.13 EFC40993.1 - 2.4e-18 65.8 0.0 6.3e-18 64.4 0.0 1.8 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 EFC40993.1 - 1.2e-11 44.1 24.0 0.00015 21.6 5.4 5.6 6 0 0 6 6 6 3 KOW motif DUF3912 PF13051.6 EFC40993.1 - 0.0011 19.2 1.8 0.27 11.5 0.0 3.3 3 0 0 3 3 3 2 Protein of unknown function (DUF3912) TFIIE-A_C PF11521.8 EFC40993.1 - 0.038 14.3 0.3 0.038 14.3 0.3 3.3 1 1 2 3 3 3 0 C-terminal general transcription factor TFIIE alpha Iso_dh PF00180.20 EFC40994.1 - 6.9e-104 347.7 0.0 9.2e-104 347.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Tim17 PF02466.19 EFC40995.1 - 6.8e-05 23.2 1.0 0.0073 16.7 0.3 3.1 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Glt_symporter PF03616.14 EFC40995.1 - 0.0059 15.3 0.0 0.01 14.6 0.0 1.3 1 0 0 1 1 1 1 Sodium/glutamate symporter DUF3169 PF11368.8 EFC40995.1 - 0.027 14.0 0.1 0.027 14.0 0.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3169) MFS_1 PF07690.16 EFC40996.1 - 1.5e-42 145.8 43.7 3.1e-29 102.0 27.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC40996.1 - 8.6e-36 123.8 21.1 1.1e-35 123.5 21.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 EFC40996.1 - 2.3e-09 37.1 5.8 2.3e-09 37.1 5.8 1.7 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TMEM215 PF15746.5 EFC40996.1 - 0.18 11.3 0.0 0.33 10.4 0.0 1.4 1 0 0 1 1 1 0 TMEM215 family Nitroreductase PF00881.24 EFC40997.1 - 3.8e-29 101.9 0.1 1.6e-28 99.9 0.1 1.8 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 EFC40997.1 - 5.9e-05 22.7 0.0 0.076 12.6 0.0 2.2 2 0 0 2 2 2 2 Putative TM nitroreductase PPR_2 PF13041.6 EFC40998.1 - 3e-08 33.7 10.0 2e-05 24.7 1.7 4.2 3 2 1 4 4 4 2 PPR repeat family PPR_3 PF13812.6 EFC40998.1 - 0.00064 19.7 8.7 0.053 13.6 0.2 4.5 4 1 1 5 5 5 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC40998.1 - 0.012 15.3 3.2 0.32 10.7 0.0 3.7 5 0 0 5 5 5 0 PPR repeat PPR PF01535.20 EFC40998.1 - 1.4 9.4 15.7 13 6.3 0.0 6.1 6 0 0 6 6 6 0 PPR repeat Rgp1 PF08737.10 EFC40999.1 - 1.5e-23 83.6 7.2 7.3e-18 64.9 0.7 2.2 1 1 1 2 2 2 2 Rgp1 Arrestin_C PF02752.22 EFC40999.1 - 3.6e-09 37.2 7.8 0.00024 21.5 0.7 2.7 2 2 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFC40999.1 - 3.5e-05 23.9 0.9 0.016 15.2 0.1 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain ComJ PF11033.8 EFC40999.1 - 0.049 13.3 0.1 0.17 11.6 0.1 1.9 1 0 0 1 1 1 0 Competence protein J (ComJ) RNB PF00773.19 EFC41001.1 - 6.6e-97 324.7 3.3 9.7e-97 324.2 3.3 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 EFC41001.1 - 1.7e-22 79.2 0.0 4.2e-22 78.0 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EFC41001.1 - 2.4e-06 27.6 0.0 0.036 14.2 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 EFC41001.1 - 5.8e-06 26.1 0.0 1.5e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EFC41001.1 - 0.0045 16.9 0.0 0.018 15.0 0.0 2.0 1 0 0 1 1 1 1 S1 domain Sod_Ni PF09055.11 EFC41001.1 - 0.0062 17.1 0.6 0.024 15.2 0.1 2.3 2 0 0 2 2 2 1 Nickel-containing superoxide dismutase OB_RNB PF08206.11 EFC41001.1 - 0.041 13.6 0.1 0.12 12.0 0.1 1.8 1 0 0 1 1 1 0 Ribonuclease B OB domain Ran-binding PF05508.11 EFC41002.1 - 0.0053 15.8 5.3 0.0082 15.2 0.5 2.1 2 0 0 2 2 2 1 RanGTP-binding protein Cauli_AT PF03233.13 EFC41002.1 - 0.017 15.0 3.0 0.024 14.6 3.0 1.3 1 0 0 1 1 1 0 Aphid transmission protein Het-C PF07217.11 EFC41002.1 - 0.042 12.4 2.8 0.027 13.0 1.1 1.5 1 1 1 2 2 2 0 Heterokaryon incompatibility protein Het-C Phage_ABA_S PF18066.1 EFC41002.1 - 0.067 13.9 0.0 0.14 12.8 0.0 1.7 1 0 0 1 1 1 0 Phage ABA sandwich domain GRAS PF03514.14 EFC41002.1 - 0.1 11.6 1.5 0.1 11.5 0.1 1.7 2 0 0 2 2 2 0 GRAS domain family DUF5601 PF18151.1 EFC41002.1 - 0.58 10.5 4.1 0.69 10.3 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5601) DUF1664 PF07889.12 EFC41002.1 - 1 9.4 5.9 0.5 10.4 1.4 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Pro_CA PF00484.19 EFC41002.1 - 3.5 7.9 6.4 1 9.7 0.1 2.6 3 0 0 3 3 3 0 Carbonic anhydrase AIP3 PF03915.13 EFC41003.1 - 0.0026 16.9 1.7 0.0049 16.0 1.7 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 DUF2207 PF09972.9 EFC41003.1 - 0.0034 16.2 5.3 0.0054 15.6 0.3 2.5 2 1 1 3 3 3 1 Predicted membrane protein (DUF2207) Baculo_PEP_C PF04513.12 EFC41003.1 - 0.013 15.5 0.9 0.066 13.2 0.2 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FAM209 PF15206.6 EFC41003.1 - 0.023 14.5 0.4 0.098 12.4 0.0 2.3 2 0 0 2 2 2 0 FAM209 family DUF2721 PF11026.8 EFC41003.1 - 0.049 13.5 0.1 0.58 10.0 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Rx_N PF18052.1 EFC41003.1 - 0.1 12.9 4.2 0.07 13.4 0.9 2.4 2 1 1 3 3 3 0 Rx N-terminal domain ApoO PF09769.9 EFC41003.1 - 0.15 12.0 2.2 7.2 6.6 0.2 2.9 2 0 0 2 2 2 0 Apolipoprotein O UPF0449 PF15136.6 EFC41003.1 - 0.35 11.4 2.1 1.1 9.8 1.1 2.3 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 GrpE PF01025.19 EFC41003.1 - 3.1 7.4 12.0 3.6 7.2 2.8 2.6 2 0 0 2 2 2 0 GrpE DUF4618 PF15397.6 EFC41003.1 - 6.1 6.2 13.4 0.085 12.3 3.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Csm1_N PF18504.1 EFC41003.1 - 8.4 6.8 9.9 25 5.3 2.0 2.7 2 0 0 2 2 2 0 Csm1 N-terminal domain LRR_6 PF13516.6 EFC41004.1 - 1.4e-45 149.4 21.4 0.00048 20.0 0.1 14.2 14 0 0 14 14 14 10 Leucine Rich repeat LRR_8 PF13855.6 EFC41004.1 - 9e-27 92.6 20.2 2.4e-08 33.6 0.1 6.6 3 2 5 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC41004.1 - 3.1e-20 71.9 26.8 0.0062 16.9 1.8 8.9 3 2 8 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41004.1 - 2.9e-07 30.1 15.9 18 6.4 0.1 10.6 11 2 0 11 11 11 1 Leucine Rich Repeat DUF4347 PF14252.6 EFC41004.1 - 5.6e-06 26.3 0.1 0.043 13.7 0.0 4.0 3 2 2 5 5 5 2 Domain of unknown function (DUF4347) ApoB100_C PF12491.8 EFC41004.1 - 0.00023 21.1 0.8 18 5.4 0.0 5.3 6 0 0 6 6 6 1 Apolipoprotein B100 C terminal Mannitol_dh PF01232.23 EFC41004.1 - 0.022 14.9 0.3 1.8 8.7 0.0 3.3 1 1 4 5 5 5 0 Mannitol dehydrogenase Rossmann domain RNA_pol_I_TF PF04090.12 EFC41004.1 - 1.6 8.2 3.8 12 5.3 0.0 3.3 3 1 0 3 3 3 0 RNA polymerase I specific initiation factor NHL PF01436.21 EFC41005.1 - 2.5e-07 30.4 0.0 0.15 12.1 0.0 3.6 3 1 0 3 3 3 3 NHL repeat SBBP PF06739.11 EFC41005.1 - 0.0043 17.0 7.7 0.075 13.0 0.1 3.7 4 1 0 4 4 4 2 Beta-propeller repeat Ldl_recept_b PF00058.17 EFC41005.1 - 0.048 14.2 0.4 11 6.6 0.0 3.5 3 1 0 3 3 3 0 Low-density lipoprotein receptor repeat class B Pkinase PF00069.25 EFC41006.1 - 6.3e-52 176.5 1.3 1.7e-51 175.1 1.3 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41006.1 - 4e-48 164.0 1.1 2.9e-43 148.0 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase EGF_2 PF07974.13 EFC41006.1 - 2.6e-11 43.7 83.2 0.0082 16.5 9.9 5.5 5 0 0 5 5 5 5 EGF-like domain SBBP PF06739.11 EFC41006.1 - 0.017 15.1 8.0 0.53 10.3 0.2 3.7 3 0 0 3 3 3 0 Beta-propeller repeat MLANA PF14991.6 EFC41006.1 - 0.031 14.6 0.0 0.088 13.1 0.0 1.8 1 0 0 1 1 1 0 Protein melan-A TMEM154 PF15102.6 EFC41006.1 - 0.059 13.3 4.0 0.046 13.6 1.0 2.2 2 0 0 2 2 2 0 TMEM154 protein family Spore_III_AB PF09548.10 EFC41006.1 - 0.096 12.8 0.9 0.15 12.2 0.1 1.7 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) APH PF01636.23 EFC41006.1 - 0.25 11.3 0.0 0.48 10.3 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family T4_Gp59_C PF08994.10 EFC41006.1 - 1.4 9.5 9.9 2.7 8.6 3.2 3.4 2 1 1 3 3 3 0 T4 gene Gp59 loader of gp41 DNA helicase C-term fn2 PF00040.19 EFC41008.1 - 0.068 13.4 1.6 0.14 12.4 0.5 2.2 2 0 0 2 2 2 0 Fibronectin type II domain DUF2207 PF09972.9 EFC41009.1 - 0.0096 14.7 0.1 0.015 14.1 0.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF1129 PF06570.11 EFC41009.1 - 0.01 15.3 0.3 0.031 13.8 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) COX4 PF02936.14 EFC41009.1 - 0.06 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV Importin_rep_6 PF18829.1 EFC41009.1 - 1.8 8.8 4.4 0.43 10.7 0.2 2.0 2 0 0 2 2 2 0 Importin repeat 6 Iwr1 PF08574.10 EFC41009.1 - 3.3 8.8 7.7 5.5 8.1 1.2 2.3 2 0 0 2 2 2 0 Transcription factor Iwr1 DUF2828 PF11443.8 EFC41010.1 - 1.9e-114 383.1 7.2 8.7e-48 162.9 2.7 4.0 1 1 2 3 3 3 3 Domain of unknown function (DUF2828) F420_ligase PF01996.16 EFC41010.1 - 0.004 16.6 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase DAO PF01266.24 EFC41011.1 - 1.4e-45 156.4 0.0 1.8e-45 156.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EFC41011.1 - 1.2e-30 105.9 0.0 2.9e-30 104.7 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EFC41011.1 - 7.4e-09 35.2 0.3 1.5e-06 27.6 0.1 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 EFC41011.1 - 7e-06 26.2 0.1 1.6e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFC41011.1 - 0.00059 19.3 0.1 0.0009 18.7 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC41011.1 - 0.00061 19.1 0.0 0.0012 18.2 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC41011.1 - 0.00088 18.1 0.1 0.0016 17.3 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EFC41011.1 - 0.0053 15.9 0.0 0.0085 15.2 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFC41011.1 - 0.017 14.4 0.0 0.094 11.9 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_3 PF13738.6 EFC41011.1 - 0.041 13.2 0.3 0.32 10.2 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC41011.1 - 0.044 12.8 0.0 0.27 10.2 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.27 EFC41011.1 - 0.1 13.2 0.0 0.29 11.7 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFC41011.1 - 0.1 11.8 0.0 0.26 10.5 0.0 1.6 2 0 0 2 2 2 0 Thi4 family BTB PF00651.31 EFC41012.1 - 4.4e-13 49.4 4.5 1.2e-11 44.9 2.1 3.3 2 1 0 2 2 2 1 BTB/POZ domain Zip PF02535.22 EFC41012.1 - 1.1 8.4 3.2 2.4 7.3 3.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter LRR_4 PF12799.7 EFC41013.1 - 0.053 14.0 23.8 1.1 9.8 0.7 6.4 5 1 4 9 9 9 0 Leucine Rich repeats (2 copies) EHN PF06441.12 EFC41014.1 - 1.3e-21 76.9 0.9 7e-21 74.6 2.0 1.6 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 EFC41014.1 - 7.3e-17 61.9 0.4 1.7e-16 60.6 0.4 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold SL4P PF17618.2 EFC41014.1 - 0.0066 16.5 0.4 0.014 15.4 0.4 1.6 1 0 0 1 1 1 1 Uncharacterized Strongylid L4 protein Hydrolase_4 PF12146.8 EFC41014.1 - 0.0098 15.2 0.0 0.2 10.9 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 HATPase_c PF02518.26 EFC41015.1 - 2.6e-24 85.9 0.2 6.1e-24 84.7 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC41015.1 - 1e-17 64.3 0.3 2e-17 63.4 0.3 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC41015.1 - 1.2e-09 38.0 0.8 2.9e-09 36.8 0.2 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.6 EFC41016.1 - 0.14 12.5 0.2 0.46 10.8 0.0 1.8 1 1 0 2 2 2 0 AAA ATPase domain RGS PF00615.19 EFC41017.1 - 0.0011 19.3 1.9 0.0022 18.3 1.9 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain MFS_1 PF07690.16 EFC41018.1 - 1.9e-22 79.7 15.8 4.6e-20 71.8 11.0 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFC41018.1 - 0.00071 18.5 15.1 0.04 12.8 14.5 3.0 1 1 1 2 2 2 1 MFS_1 like family Sugar_tr PF00083.24 EFC41018.1 - 0.00079 18.4 10.2 0.0019 17.2 8.7 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter 5_nucleotid_C PF02872.18 EFC41019.1 - 3.8e-35 121.4 0.0 6.6e-35 120.7 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EFC41019.1 - 6.5e-12 46.4 0.1 1.4e-11 45.3 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SplA PF11132.8 EFC41019.1 - 0.2 11.5 1.0 2.2 8.1 0.1 2.7 3 0 0 3 3 3 0 Transcriptional regulator protein (SplA) PseudoU_synth_1 PF01416.20 EFC41020.1 - 1.6e-11 44.6 0.1 2.6e-06 27.8 0.1 2.9 2 1 0 2 2 2 2 tRNA pseudouridine synthase DUF2098 PF09871.9 EFC41020.1 - 3.6 8.0 7.4 11 6.5 7.4 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) RNA_lig_T4_1 PF09511.10 EFC41021.1 - 1.2e-33 116.8 0.8 3.5e-33 115.3 0.8 1.8 1 0 0 1 1 1 1 RNA ligase Lyase_catalyt PF09093.11 EFC41021.1 - 0.038 13.1 0.0 0.1 11.7 0.0 1.8 1 1 0 1 1 1 0 Lyase, catalytic ADH_zinc_N PF00107.26 EFC41022.1 - 1.7e-17 63.6 0.0 4.1e-17 62.4 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC41022.1 - 6.6e-15 54.9 1.9 1.3e-14 53.9 1.9 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFC41022.1 - 1.9e-07 32.2 0.0 3.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 EFC41022.1 - 2.4e-06 27.2 0.0 3.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 EFC41022.1 - 5.9e-05 22.5 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 EFC41022.1 - 0.00036 20.0 0.0 0.00064 19.1 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFC41022.1 - 0.0019 18.4 0.6 0.01 16.0 0.0 2.5 2 1 1 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.21 EFC41022.1 - 0.014 14.7 0.0 0.13 11.6 0.0 2.2 2 0 0 2 2 2 0 ThiF family 3HCDH_N PF02737.18 EFC41022.1 - 0.041 13.8 0.0 0.085 12.7 0.0 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain BKACE PF05853.12 EFC41022.1 - 0.069 12.5 0.0 0.13 11.5 0.0 1.5 1 1 0 1 1 1 0 beta-keto acid cleavage enzyme Helicase_C PF00271.31 EFC41023.1 - 0.14 12.5 2.2 1.3 9.4 0.6 2.3 2 0 0 2 2 2 0 Helicase conserved C-terminal domain UT PF03253.14 EFC41023.1 - 0.38 9.8 1.4 0.58 9.2 1.4 1.2 1 0 0 1 1 1 0 Urea transporter Voltage_CLC PF00654.20 EFC41025.1 - 7e-58 196.6 28.4 1.3e-56 192.4 24.8 3.0 2 1 0 2 2 2 1 Voltage gated chloride channel BLOC1S3 PF15753.5 EFC41025.1 - 0.11 12.6 1.7 0.25 11.5 1.7 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 DUF2929 PF11151.8 EFC41025.1 - 6.5 7.1 11.4 28 5.1 0.6 4.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) DUF2053 PF09767.9 EFC41026.1 - 9.9e-55 185.1 5.6 9.9e-55 185.1 5.6 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2053) RCC1_2 PF13540.6 EFC41027.1 - 5.2e-17 61.2 8.4 1.1e-09 37.8 0.1 5.8 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC41027.1 - 3.9e-15 56.2 1.3 0.0096 16.5 0.0 6.9 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Fer4_21 PF14697.6 EFC41028.1 - 0.037 14.2 1.3 0.13 12.4 1.3 1.9 1 0 0 1 1 1 0 4Fe-4S dicluster domain PAS_2 PF08446.11 EFC41028.1 - 0.28 11.9 3.8 4.2 8.1 1.1 2.4 2 0 0 2 2 2 0 PAS fold DUF3678 PF12435.8 EFC41028.1 - 0.98 8.8 4.2 0.82 9.1 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Cadherin_C_2 PF16492.5 EFC41029.1 - 0.047 14.4 0.4 4.9 8.0 0.2 2.8 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF5516 PF17637.2 EFC41029.1 - 0.34 10.7 2.3 0.82 9.5 2.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5516) 7tm_2 PF00002.24 EFC41029.1 - 3 7.0 9.3 0.65 9.2 0.1 3.3 3 1 0 3 3 3 0 7 transmembrane receptor (Secretin family) DUF4834 PF16118.5 EFC41029.1 - 8.7 7.4 6.4 6.9 7.7 0.3 3.6 3 2 0 3 3 3 0 Domain of unknown function (DUF4834) Peptidase_M20 PF01546.28 EFC41030.1 - 1.9e-30 106.1 0.6 3.5e-30 105.3 0.6 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC41030.1 - 5.2e-14 52.1 0.1 1.7e-13 50.5 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain ubiquitin PF00240.23 EFC41031.1 - 2.3e-05 24.1 0.2 8e-05 22.3 0.1 1.9 2 0 0 2 2 2 1 Ubiquitin family UBA PF00627.31 EFC41031.1 - 0.00018 21.4 0.2 0.00063 19.6 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain Glyco_hydro_2 PF00703.21 EFC41031.1 - 0.14 12.8 1.4 0.31 11.7 0.1 2.1 2 1 0 2 2 2 0 Glycosyl hydrolases family 2 RGS PF00615.19 EFC41032.1 - 1.9e-13 50.7 4.8 1.9e-13 50.7 4.8 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain SPA PF08616.10 EFC41033.1 - 9.7e-29 99.6 0.1 2.9e-28 98.1 0.1 1.9 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 EFC41033.1 - 1.9e-21 76.2 8.3 5.2e-13 48.4 1.5 3.7 2 1 1 3 3 3 2 Transport protein Avl9 DENN PF02141.21 EFC41033.1 - 4.9e-08 33.2 1.6 1.4e-07 31.6 1.6 1.9 1 1 0 1 1 1 1 DENN (AEX-3) domain Afi1 PF07792.12 EFC41033.1 - 2.3e-06 28.1 0.1 8e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking L_HMGIC_fpl PF10242.9 EFC41033.1 - 0.0026 18.0 0.0 0.0078 16.4 0.0 1.8 1 0 0 1 1 1 1 Lipoma HMGIC fusion partner-like protein Pox_polyA_pol_C PF12629.7 EFC41033.1 - 0.012 15.4 0.3 0.012 15.4 0.3 2.2 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase C-terminal domain ICAT PF06384.11 EFC41034.1 - 7.5e-06 26.1 2.3 7.5e-06 26.1 2.3 2.4 2 1 0 2 2 2 1 Beta-catenin-interacting protein ICAT Laminin_II PF06009.12 EFC41034.1 - 0.014 15.4 1.9 0.014 15.4 1.9 2.0 1 1 1 2 2 2 0 Laminin Domain II PmrD PF11183.8 EFC41034.1 - 0.014 15.5 0.5 0.22 11.7 0.0 2.1 1 1 1 2 2 2 0 Polymyxin resistance protein PmrD DUF4476 PF14771.6 EFC41034.1 - 0.02 15.2 0.5 0.046 14.0 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) DUF2120 PF09893.9 EFC41034.1 - 0.043 13.9 2.8 3.7 7.7 0.2 2.1 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) VWA PF00092.28 EFC41034.1 - 0.053 13.8 2.0 0.33 11.2 0.3 2.0 1 1 1 2 2 2 0 von Willebrand factor type A domain DUF4527 PF15030.6 EFC41034.1 - 1.2 8.5 8.8 0.34 10.3 5.0 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF4527) APG6_N PF17675.1 EFC41034.1 - 2.6 8.6 20.2 0.13 12.8 12.1 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region EGF_2 PF07974.13 EFC41035.1 - 2.7e-06 27.7 60.4 0.013 15.9 7.1 5.5 6 0 0 6 6 6 4 EGF-like domain DOMON PF03351.17 EFC41035.1 - 0.015 15.5 0.6 0.041 14.1 0.6 1.7 1 0 0 1 1 1 0 DOMON domain PD40 PF07676.12 EFC41035.1 - 0.015 15.2 1.4 3.9 7.5 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat EphA2_TM PF14575.6 EFC41035.1 - 0.037 14.9 0.0 1.1 10.2 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4320 PF14208.6 EFC41035.1 - 0.86 9.7 4.7 8.5 6.5 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4320) HATPase_c PF02518.26 EFC41036.1 - 6.8e-22 78.1 0.3 1.5e-21 77.0 0.3 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC41036.1 - 5e-17 62.1 0.3 9.8e-17 61.1 0.3 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC41036.1 - 3.6e-09 36.5 1.0 3.6e-09 36.5 1.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain SAM_2 PF07647.17 EFC41037.1 - 6.6e-06 26.1 0.1 1.3e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC41037.1 - 7e-06 26.4 0.1 1.6e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PXPV PF12778.7 EFC41039.1 - 0.0011 18.8 38.3 0.014 15.3 10.1 3.8 1 1 3 4 4 4 4 PXPV repeat (3 copies) EGF_2 PF07974.13 EFC41040.1 - 4.9e-10 39.6 149.7 0.0014 19.0 6.4 11.3 10 1 1 11 11 10 8 EGF-like domain UPF0242 PF06785.11 EFC41040.1 - 0.00032 20.9 7.1 0.0008 19.6 7.1 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus RRM_1 PF00076.22 EFC41040.1 - 0.0069 16.2 0.0 0.022 14.6 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EGF PF00008.27 EFC41040.1 - 0.0096 16.2 7.2 0.0096 16.2 7.2 10.2 10 0 0 10 10 8 3 EGF-like domain Leu_zip PF15294.6 EFC41040.1 - 0.03 13.8 16.2 0.027 14.0 14.2 1.9 1 1 1 2 2 2 0 Leucine zipper Apolipoprotein PF01442.18 EFC41040.1 - 0.042 13.7 0.9 0.1 12.5 0.7 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EFC41040.1 - 0.066 13.3 15.2 0.073 13.1 6.7 3.6 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus E2R135 PF11570.8 EFC41040.1 - 0.11 12.9 2.8 0.36 11.1 2.8 1.9 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 Prefoldin_2 PF01920.20 EFC41040.1 - 0.26 11.3 16.9 1.1 9.2 2.0 4.5 3 1 2 5 5 5 0 Prefoldin subunit CALCOCO1 PF07888.11 EFC41040.1 - 0.47 9.3 12.6 0.82 8.5 12.6 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Tropomyosin PF00261.20 EFC41040.1 - 0.47 9.8 14.8 0.49 9.7 5.8 2.3 1 1 1 2 2 2 0 Tropomyosin DivIC PF04977.15 EFC41040.1 - 0.51 10.1 7.2 9.1 6.1 0.8 3.7 3 0 0 3 3 3 0 Septum formation initiator TSC22 PF01166.18 EFC41040.1 - 0.59 10.5 7.7 0.15 12.4 1.8 2.8 3 0 0 3 3 3 0 TSC-22/dip/bun family Tup_N PF08581.10 EFC41040.1 - 1.4 9.3 6.2 29 5.0 0.1 3.6 2 1 1 3 3 3 0 Tup N-terminal DASH_Dam1 PF08653.10 EFC41040.1 - 1.4 8.8 5.3 1.8 8.5 0.5 3.0 2 0 0 2 2 2 0 DASH complex subunit Dam1 YabA PF06156.13 EFC41040.1 - 2.2 9.0 11.6 11 6.7 1.3 3.2 2 0 0 2 2 2 0 Initiation control protein YabA DUF948 PF06103.11 EFC41040.1 - 2.7 8.3 6.2 3.2 8.1 0.4 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LPP PF04728.13 EFC41040.1 - 4.8 7.6 10.4 16 6.0 0.0 4.6 3 1 1 4 4 4 0 Lipoprotein leucine-zipper FlaC_arch PF05377.11 EFC41040.1 - 7.7 7.0 20.0 3.4 8.1 2.6 4.4 3 1 2 5 5 5 0 Flagella accessory protein C (FlaC) Mei5_like PF17021.5 EFC41040.1 - 8.5 6.5 10.4 1.1 9.3 5.1 2.3 2 1 0 2 2 2 0 Putative double-strand recombination repair-like STAT_alpha PF01017.20 EFC41040.1 - 9.4 6.1 11.7 0.36 10.7 5.0 2.2 2 1 1 3 3 2 0 STAT protein, all-alpha domain REJ PF02010.15 EFC41041.1 - 9.8e-22 77.4 18.9 2.8e-19 69.3 14.7 2.5 1 1 1 2 2 2 2 REJ domain Shisa PF13908.6 EFC41041.1 - 0.0062 16.8 0.7 0.0062 16.8 0.7 2.5 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator REJ PF02010.15 EFC41042.1 - 1.6e-20 73.4 19.3 7.3e-19 67.9 14.1 2.5 1 1 1 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC41042.1 - 0.042 14.2 98.7 0.038 14.3 8.2 7.8 8 0 0 8 8 8 0 EGF-like domain Menin PF05053.13 EFC41043.1 - 0.37 9.1 4.5 0.49 8.7 4.5 1.1 1 0 0 1 1 1 0 Menin HEXIM PF15313.6 EFC41044.1 - 0.01 16.0 0.4 0.025 14.8 0.0 1.8 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein SprA-related PF12118.8 EFC41044.1 - 5.2 6.1 16.2 8.4 5.4 16.2 1.3 1 0 0 1 1 1 0 SprA-related family Mucin PF01456.17 EFC41044.1 - 8.2 6.4 27.3 17 5.4 27.3 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein C2 PF00168.30 EFC41045.1 - 1.8e-13 50.7 0.1 4.9e-13 49.3 0.1 1.7 1 0 0 1 1 1 1 C2 domain zf-B_box PF00643.24 EFC41045.1 - 7.1e-06 26.1 8.8 1.2e-05 25.4 8.8 1.3 1 0 0 1 1 1 1 B-box zinc finger DUF4515 PF14988.6 EFC41045.1 - 0.00039 20.3 3.7 0.00089 19.2 3.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) RIG-I_C-RD PF11648.8 EFC41045.1 - 0.0017 18.6 3.4 0.0046 17.2 3.4 1.8 1 0 0 1 1 1 1 C-terminal domain of RIG-I NMT PF01233.19 EFC41045.1 - 0.032 14.1 0.5 0.032 14.1 0.5 1.8 2 0 0 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain SUI1 PF01253.22 EFC41045.1 - 0.075 13.6 0.3 0.075 13.6 0.3 2.0 2 0 0 2 2 2 0 Translation initiation factor SUI1 UPF0014 PF03649.13 EFC41045.1 - 0.22 10.9 0.0 0.36 10.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0014) DUF4404 PF14357.6 EFC41045.1 - 2.7 8.7 5.7 4.1 8.1 3.3 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) WD40 PF00400.32 EFC41046.1 - 3.2e-15 56.3 9.7 0.0045 17.8 0.1 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC41046.1 - 4.6e-09 36.4 0.2 0.76 10.1 0.0 5.0 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1631 PF07793.11 EFC41046.1 - 0.072 11.5 0.3 0.11 10.9 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) BBS2_Mid PF14783.6 EFC41046.1 - 0.11 12.6 0.9 6.3 6.9 0.0 3.0 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Pneumo_att_G PF05539.11 EFC41046.1 - 9.9 5.6 13.0 0.46 10.0 4.3 2.1 2 0 0 2 2 2 0 Pneumovirinae attachment membrane glycoprotein G TPR_2 PF07719.17 EFC41047.1 - 4.4e-53 173.2 64.0 4.6e-06 26.3 0.2 23.1 23 0 0 23 23 22 10 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41047.1 - 7.8e-48 158.4 68.8 2.5e-05 23.9 0.8 21.8 23 0 0 23 23 23 12 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41047.1 - 7.3e-43 141.2 72.6 4.6e-06 26.4 0.4 22.6 23 1 1 24 24 23 12 Tetratricopeptide repeat TPR_14 PF13428.6 EFC41047.1 - 3e-39 130.3 2.5 0.009 16.8 0.0 19.5 17 2 5 22 22 22 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41047.1 - 9.5e-34 114.8 37.0 0.00037 20.1 0.0 18.2 16 1 3 19 19 19 9 TPR repeat TPR_12 PF13424.6 EFC41047.1 - 3.1e-27 94.7 29.3 0.00066 19.9 0.6 15.1 13 4 3 16 16 15 7 Tetratricopeptide repeat TPR_16 PF13432.6 EFC41047.1 - 1.2e-26 93.0 7.3 0.0012 19.5 0.1 10.4 10 1 0 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFC41047.1 - 1.3e-24 86.5 26.7 0.00054 20.4 0.6 16.0 17 1 2 19 19 18 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC41047.1 - 4e-23 80.1 58.6 0.0086 16.4 0.5 21.5 25 0 0 25 25 22 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFC41047.1 - 3.8e-13 49.2 31.3 0.00037 21.0 0.0 14.0 14 0 0 14 14 12 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC41047.1 - 1.7e-07 31.4 41.7 0.027 14.7 0.4 13.1 10 3 2 13 13 12 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EFC41047.1 - 1.9e-06 27.5 10.5 0.25 10.7 0.0 7.9 7 2 3 10 10 10 1 MalT-like TPR region TPR_10 PF13374.6 EFC41047.1 - 7.6e-05 22.5 28.8 0.083 12.8 0.0 12.7 14 1 1 15 15 15 1 Tetratricopeptide repeat DUF4810 PF16068.5 EFC41047.1 - 0.036 14.6 0.3 3.6 8.2 0.0 4.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4810) TPR_7 PF13176.6 EFC41047.1 - 0.1 12.7 33.2 0.89 9.7 0.0 13.6 18 1 0 18 18 17 0 Tetratricopeptide repeat PPTA PF01239.22 EFC41047.1 - 0.53 10.1 6.2 12 5.8 0.0 4.7 5 0 0 5 5 4 0 Protein prenyltransferase alpha subunit repeat Fis1_TPR_C PF14853.6 EFC41047.1 - 1.2 9.3 29.1 4.8 7.3 0.2 9.6 12 0 0 12 12 11 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 EFC41047.1 - 7.8 7.0 16.9 8.2 6.9 0.1 8.1 10 0 0 10 10 8 0 PPR repeat S_layer_N PF05123.12 EFC41048.1 - 5.6 6.7 8.7 11 5.8 8.7 1.4 1 0 0 1 1 1 0 S-layer like family, N-terminal region Ldi PF18566.1 EFC41050.1 - 0.075 12.5 0.1 0.15 11.5 0.1 1.5 1 0 0 1 1 1 0 Linalool dehydratase/isomerase ASD2 PF08687.11 EFC41050.1 - 0.43 10.1 7.8 0.8 9.2 7.8 1.4 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Presenilin PF01080.17 EFC41050.1 - 0.65 8.7 5.5 1.1 8.0 5.5 1.3 1 0 0 1 1 1 0 Presenilin DUF3899 PF13038.6 EFC41051.1 - 0.015 15.8 0.2 0.059 13.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) RRM_1 PF00076.22 EFC41052.1 - 5.6e-11 42.1 0.9 2e-10 40.3 0.0 2.4 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5596 PF18082.1 EFC41052.1 - 0.15 11.9 0.0 0.41 10.5 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5596) Nucleoside_tran PF01733.18 EFC41053.1 - 5.6e-61 206.6 13.8 8.6e-61 206.0 13.8 1.3 1 0 0 1 1 1 1 Nucleoside transporter Myb_Cef PF11831.8 EFC41054.1 - 0.0017 18.0 0.1 0.0024 17.5 0.1 1.2 1 0 0 1 1 1 1 pre-mRNA splicing factor component FRQ PF09421.10 EFC41054.1 - 0.033 12.2 0.4 0.033 12.2 0.4 1.2 1 0 0 1 1 1 0 Frequency clock protein KLRAQ PF10205.9 EFC41055.1 - 3.1e-08 33.7 16.7 3.1e-08 33.7 16.7 5.6 3 2 4 7 7 7 1 Predicted coiled-coil domain-containing protein Golgin_A5 PF09787.9 EFC41055.1 - 6.6 6.1 69.3 0.88 9.0 14.4 4.4 4 0 0 4 4 4 0 Golgin subfamily A member 5 zf-RING_UBOX PF13445.6 EFC41056.1 - 2.3e-10 40.3 6.6 5.8e-10 39.0 6.6 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFC41056.1 - 4.9e-10 39.6 8.2 4.9e-10 39.6 8.2 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFC41056.1 - 7.9e-09 35.2 5.0 1.4e-08 34.4 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC41056.1 - 3.5e-08 33.2 9.1 7e-08 32.2 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFC41056.1 - 8.6e-08 32.2 9.2 1.6e-07 31.4 9.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFC41056.1 - 1e-06 28.5 8.2 1.9e-06 27.7 8.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFC41056.1 - 1.4e-05 24.8 8.1 2.8e-05 23.8 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EFC41056.1 - 3.9e-05 23.4 3.1 9.6e-05 22.1 3.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EFC41056.1 - 6.9e-05 22.6 6.8 6.9e-05 22.6 6.8 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 EFC41056.1 - 0.00011 22.1 3.6 0.00031 20.5 3.6 1.7 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EFC41056.1 - 0.00038 20.7 7.7 0.0013 19.0 7.7 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFC41056.1 - 0.011 15.7 2.0 0.011 15.7 2.0 1.7 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 EFC41056.1 - 0.021 14.6 5.1 0.021 14.6 5.1 2.0 2 0 0 2 2 2 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EFC41056.1 - 0.054 13.1 4.5 0.1 12.2 4.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-MIZ PF02891.20 EFC41056.1 - 2.4 8.0 7.0 4.5 7.1 7.0 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-C3H2C3 PF17122.5 EFC41056.1 - 4.7 7.3 8.1 39 4.4 8.1 2.2 1 1 0 1 1 1 0 Zinc-finger PDEase_II PF02112.15 EFC41057.1 - 2e-49 168.5 5.2 2.8e-49 168.0 5.2 1.2 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Pribosyltran PF00156.27 EFC41058.1 - 2.8e-17 62.7 0.0 3.8e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain ubiquitin PF00240.23 EFC41059.1 - 0.00047 19.9 0.1 0.0012 18.5 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family zf-C2H2_aberr PF17017.5 EFC41059.1 - 0.021 15.0 1.5 0.021 15.0 1.5 1.8 2 0 0 2 2 2 0 Aberrant zinc-finger Pkinase PF00069.25 EFC41060.1 - 9.3e-18 64.5 0.3 9.3e-18 64.5 0.3 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41060.1 - 2.8e-09 36.7 0.1 6.1e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1981 PF09324.10 EFC41060.1 - 0.83 9.5 2.8 1.5 8.7 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) Casc1_N PF15927.5 EFC41060.1 - 3.1 7.4 16.5 8.3 6.0 13.6 2.4 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus HSP20 PF00011.21 EFC41061.1 - 4.2e-23 81.4 4.4 5.5e-23 81.1 4.4 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC41061.1 - 2.3e-08 33.4 0.0 3.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 HSP20-like domain found in ArsA REF PF05755.12 EFC41061.1 - 0.05 13.4 0.0 0.084 12.7 0.0 1.5 1 1 0 1 1 1 0 Rubber elongation factor protein (REF) FlgM PF04316.13 EFC41061.1 - 0.06 13.7 0.0 0.19 12.1 0.0 1.8 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM DUF4251 PF14059.6 EFC41061.1 - 0.12 12.3 1.6 0.21 11.5 0.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4251) Cu_bind_like PF02298.17 EFC41062.1 - 0.84 9.7 3.6 4.9 7.2 0.1 3.0 3 0 0 3 3 3 0 Plastocyanin-like domain 2OG-FeII_Oxy_2 PF13532.6 EFC41064.1 - 1.3e-15 58.1 0.0 5.3e-14 52.8 0.0 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ras PF00071.22 EFC41065.1 - 3.4e-55 186.1 0.5 4.2e-55 185.8 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41065.1 - 4.6e-21 75.2 0.0 7.9e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41065.1 - 2.9e-11 43.1 0.0 3.6e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EFC41065.1 - 1.1e-06 28.6 0.9 6.6e-06 26.1 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFC41065.1 - 2.1e-05 24.5 0.1 0.038 13.9 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC41065.1 - 0.00033 20.3 0.2 0.00098 18.7 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC41065.1 - 0.0011 19.0 0.1 0.0032 17.5 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 EFC41065.1 - 0.035 13.4 0.2 0.28 10.4 0.0 2.1 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 EFC41065.1 - 0.045 13.9 0.0 0.092 12.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF4604 PF15377.6 EFC41065.1 - 3.7 8.0 10.3 6.8 7.1 10.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) Ax_dynein_light PF10211.9 EFC41066.1 - 5.3e-83 277.6 16.4 6.6e-83 277.3 16.4 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain bZIP_2 PF07716.15 EFC41066.1 - 0.005 16.9 18.7 0.038 14.1 10.1 2.8 2 0 0 2 2 2 2 Basic region leucine zipper DUF3523 PF12037.8 EFC41066.1 - 0.27 10.6 16.4 0.43 9.9 16.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) DUF728 PF05304.12 EFC41066.1 - 0.43 10.4 3.5 0.71 9.7 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF728) FapA PF03961.13 EFC41066.1 - 0.58 8.7 10.2 0.74 8.4 10.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIC PF04977.15 EFC41066.1 - 2.1 8.2 15.8 9.7 6.0 4.4 2.7 1 1 1 2 2 2 0 Septum formation initiator FlxA PF14282.6 EFC41066.1 - 4.6 7.3 15.8 5.3 7.1 14.0 2.1 2 1 0 2 2 2 0 FlxA-like protein APG6_N PF17675.1 EFC41066.1 - 7.7 7.0 24.6 9.2 6.8 22.0 2.5 1 1 0 2 2 2 0 Apg6 coiled-coil region MbeD_MobD PF04899.12 EFC41066.1 - 8.1 6.6 12.3 3.4 7.9 7.6 2.5 3 0 0 3 3 3 0 MbeD/MobD like Mei5 PF10376.9 EFC41066.1 - 9.4 6.0 22.9 29 4.4 22.8 2.0 1 1 0 1 1 1 0 Double-strand recombination repair protein PCRF PF03462.18 EFC41067.1 - 8e-44 149.8 0.0 8e-44 149.8 0.0 2.1 2 1 0 2 2 2 1 PCRF domain RF-1 PF00472.20 EFC41067.1 - 1.1e-39 135.0 2.5 3.1e-39 133.5 2.5 1.7 1 0 0 1 1 1 1 RF-1 domain TPR_15 PF13429.6 EFC41067.1 - 0.039 13.2 0.2 0.058 12.6 0.2 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Nrap_D5 PF17406.2 EFC41068.1 - 8.9e-29 100.3 0.1 2.6e-28 98.8 0.1 1.9 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 EFC41068.1 - 1.5e-17 64.1 0.5 4.2e-17 62.7 0.1 2.0 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D4 PF17405.2 EFC41068.1 - 2.2e-16 59.9 1.3 4.3e-16 58.9 0.2 2.0 2 0 0 2 2 2 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D6 PF17407.2 EFC41068.1 - 6.8e-11 42.5 0.1 8.3e-10 39.0 0.1 2.6 1 1 0 1 1 1 1 Nrap protein domain 6 Nrap_D2 PF17403.2 EFC41068.1 - 1.3e-08 34.7 0.1 1.5e-06 28.1 0.0 2.7 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Qn_am_d_aIV PF09100.10 EFC41068.1 - 0.039 13.8 0.0 0.09 12.6 0.0 1.6 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV tRNA_NucTran2_2 PF13735.6 EFC41068.1 - 0.078 13.0 0.6 1.2 9.1 0.0 2.6 3 0 0 3 3 3 0 tRNA nucleotidyltransferase domain 2 putative Epimerase_2 PF02350.19 EFC41069.1 - 4.9e-94 315.0 2.1 1.9e-91 306.5 0.4 2.4 2 0 0 2 2 2 2 UDP-N-acetylglucosamine 2-epimerase Glyco_tranf_2_3 PF13641.6 EFC41069.1 - 1.1e-07 31.9 0.1 5.9e-05 23.1 0.0 3.6 3 1 0 3 3 3 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 EFC41069.1 - 6.4e-05 22.8 0.0 0.00022 21.1 0.0 2.0 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF4862 PF16154.5 EFC41069.1 - 0.0043 16.5 0.0 0.0084 15.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4862) Glycos_transf_N PF04413.16 EFC41069.1 - 0.0062 16.2 0.0 0.024 14.3 0.0 2.1 1 1 0 1 1 1 1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) FleQ PF06490.11 EFC41069.1 - 0.038 14.3 0.0 82 3.6 0.1 4.4 5 0 0 5 5 5 0 Flagellar regulatory protein FleQ ANF_receptor PF01094.28 EFC41069.1 - 0.31 10.1 2.6 0.54 9.3 0.6 2.4 2 1 0 2 2 2 0 Receptor family ligand binding region AAA_22 PF13401.6 EFC41071.1 - 1.4e-05 25.4 0.1 0.0095 16.2 0.1 2.8 2 0 0 2 2 2 2 AAA domain PAH PF02671.21 EFC41071.1 - 0.011 15.9 1.8 22 5.3 0.1 4.4 4 0 0 4 4 4 0 Paired amphipathic helix repeat NACHT PF05729.12 EFC41071.1 - 0.024 14.5 0.0 0.31 11.0 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 EFC41071.1 - 0.027 14.7 0.0 1.3 9.2 0.0 2.9 2 0 0 2 2 2 0 AAA domain Rotamase_2 PF13145.6 EFC41071.1 - 0.038 14.8 0.2 0.038 14.8 0.2 2.6 3 0 0 3 3 3 0 PPIC-type PPIASE domain IMUP PF15761.5 EFC41071.1 - 0.072 13.8 16.1 0.18 12.5 3.8 2.6 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF4385 PF14328.6 EFC41071.1 - 0.077 13.1 2.4 0.19 11.8 2.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4385) PDGLE PF13190.6 EFC41071.1 - 0.12 12.3 0.0 4 7.4 0.0 2.6 2 0 0 2 2 2 0 PDGLE domain Cass2 PF14526.6 EFC41071.1 - 0.22 11.7 4.5 0.3 11.3 0.3 3.2 3 0 0 3 3 3 0 Integron-associated effector binding protein PRKCSH_1 PF13015.6 EFC41072.1 - 0.055 13.2 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein BTB PF00651.31 EFC41073.1 - 1.6e-05 25.1 1.6 3.7e-05 23.9 1.6 1.6 1 0 0 1 1 1 1 BTB/POZ domain RCC1 PF00415.18 EFC41073.1 - 0.0067 17.0 0.5 1.7 9.3 0.0 2.8 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Flavodoxin_2 PF02525.17 EFC41074.1 - 2.9e-20 72.8 0.0 3.4e-20 72.6 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FBA_2 PF07735.17 EFC41074.1 - 0.043 13.9 0.1 12 6.1 0.0 3.0 2 1 0 2 2 2 0 F-box associated DUF1963 PF09234.10 EFC41075.1 - 5.4e-09 36.8 1.0 1.8e-08 35.1 0.3 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF1963) F-box PF00646.33 EFC41075.1 - 6.9e-05 22.6 1.2 0.00019 21.2 0.1 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC41075.1 - 0.00053 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like Amidohydro_1 PF01979.20 EFC41076.1 - 8.3e-19 68.1 0.4 1.8e-18 67.0 0.4 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFC41076.1 - 1.7e-13 50.9 0.0 2.4e-13 50.4 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family EGF_2 PF07974.13 EFC41078.1 - 8.6e-43 144.4 197.7 3.9e-05 23.9 5.4 13.5 13 0 0 13 13 13 13 EGF-like domain Pkinase_Tyr PF07714.17 EFC41078.1 - 4.1e-24 85.3 0.0 8.3e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC41078.1 - 4.7e-19 68.8 0.8 2.3e-18 66.5 0.1 2.3 2 0 0 2 2 2 1 Protein kinase domain LIG3_BRCT PF16759.5 EFC41078.1 - 0.04 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain EGF PF00008.27 EFC41078.1 - 5.2 7.5 147.5 0.11 12.8 2.9 13.9 14 0 0 14 14 14 0 EGF-like domain Ank_4 PF13637.6 EFC41079.1 - 0.006 17.1 0.1 0.43 11.2 0.1 3.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC41079.1 - 0.026 15.1 0.0 0.085 13.5 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) F-box-like PF12937.7 EFC41079.1 - 0.089 12.7 0.0 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 F-box-like Ank_3 PF13606.6 EFC41079.1 - 0.2 12.3 0.4 1.7 9.4 0.1 2.8 2 0 0 2 2 2 0 Ankyrin repeat GSHPx PF00255.19 EFC41080.1 - 2.8e-32 110.5 0.6 3.6e-32 110.2 0.6 1.1 1 0 0 1 1 1 1 Glutathione peroxidase zf-MYND PF01753.18 EFC41081.1 - 9.3e-09 35.2 13.3 2.8e-08 33.7 13.3 1.9 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 EFC41081.1 - 0.22 11.4 14.0 0.36 10.7 9.7 2.6 2 0 0 2 2 2 0 HIT zinc finger zf-C6H2 PF15801.5 EFC41081.1 - 0.46 10.8 14.2 1.6 9.1 14.2 2.0 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DUF4116 PF13475.6 EFC41082.1 - 7.8e-53 176.0 36.7 2.3e-12 46.4 0.0 13.2 5 5 10 15 15 15 13 Domain of unknown function (DUF4116) Pox_A3L PF05288.11 EFC41082.1 - 0.081 12.9 1.7 0.47 10.5 0.2 3.2 2 0 0 2 2 2 0 Poxvirus A3L Protein Pkinase PF00069.25 EFC41083.1 - 7.2e-54 182.9 0.0 1.4e-53 181.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41083.1 - 2.8e-50 171.0 0.0 3.2e-44 151.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC41083.1 - 0.00055 19.0 0.0 0.0014 17.6 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC41083.1 - 0.0019 18.2 0.0 0.0029 17.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Chlam_PMP PF02415.17 EFC41083.1 - 0.86 10.2 40.5 0.79 10.3 0.1 8.6 9 0 0 9 9 9 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat E1_dh PF00676.20 EFC41084.1 - 6.4e-56 189.5 0.0 1.1e-55 188.8 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 EFC41084.1 - 4.6e-54 182.8 0.0 6.9e-54 182.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EFC41084.1 - 6.2e-49 165.6 0.2 1.3e-48 164.5 0.2 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal PI-TkoII_IV PF18714.1 EFC41084.1 - 0.05 13.1 0.0 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase II intein Domain IV HSP70 PF00012.20 EFC41085.1 - 1.4e-30 106.1 0.0 1.8e-30 105.8 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein LRR_6 PF13516.6 EFC41086.1 - 7.3e-18 63.0 54.1 0.0015 18.4 0.2 11.7 12 0 0 12 12 12 5 Leucine Rich repeat LRR_4 PF12799.7 EFC41086.1 - 5.1e-16 58.5 62.7 8e-06 26.1 3.6 8.9 4 2 5 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC41086.1 - 5.9e-16 58.0 51.8 2.3e-06 27.3 7.0 7.3 5 2 1 7 7 7 5 Leucine rich repeat LRR_9 PF14580.6 EFC41086.1 - 4.4e-06 26.3 19.6 3.2e-05 23.5 2.5 4.7 2 1 2 5 5 5 2 Leucine-rich repeat LRR_1 PF00560.33 EFC41086.1 - 0.001 19.3 45.5 1.6 9.6 0.4 10.9 11 0 0 11 11 11 4 Leucine Rich Repeat F-box-like PF12937.7 EFC41086.1 - 0.0095 15.8 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.13 EFC41086.1 - 0.0098 16.5 2.9 61 4.5 0.0 6.2 5 0 0 5 5 5 0 Leucine Rich Repeat DUF4116 PF13475.6 EFC41087.1 - 1.9e-39 133.1 17.0 7.9e-15 54.3 0.1 6.1 6 1 1 7 7 7 5 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC41087.1 - 1.7e-24 86.6 5.3 1.7e-24 86.6 5.3 3.4 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41087.1 - 1.8e-09 37.3 0.9 1.4e-08 34.3 0.4 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFC41087.1 - 0.0029 17.0 0.1 0.0064 15.9 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFC41087.1 - 0.016 14.8 0.1 0.016 14.8 0.1 3.0 3 0 0 3 3 3 0 RIO1 family DUF1640 PF07798.11 EFC41087.1 - 0.11 12.6 5.7 0.09 12.8 1.6 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) bZIP_1 PF00170.21 EFC41087.1 - 0.58 10.3 7.3 2.9 8.0 7.3 2.3 1 0 0 1 1 1 0 bZIP transcription factor FlaC_arch PF05377.11 EFC41087.1 - 0.82 10.1 8.8 0.4 11.1 1.9 3.3 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 EFC41087.1 - 4.3 7.8 14.2 0.27 11.7 7.3 2.6 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 EFC41087.1 - 5.7 6.8 11.8 0.82 9.5 5.9 2.7 3 0 0 3 3 3 0 Septum formation initiator HALZ PF02183.18 EFC41087.1 - 6.4 7.1 9.1 11 6.3 0.5 3.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper Shugoshin_N PF07558.11 EFC41087.1 - 9.4 6.2 15.9 3 7.8 11.3 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region RCC1 PF00415.18 EFC41088.1 - 1e-16 61.3 0.0 4.3e-09 36.8 0.0 5.5 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC41088.1 - 7.3e-16 57.5 9.2 3.8e-05 23.4 0.4 5.5 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat PH_18 PF18469.1 EFC41088.1 - 0.075 13.0 0.1 5.1 7.1 0.0 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain F-box PF00646.33 EFC41089.1 - 0.056 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 F-box domain Kelch_4 PF13418.6 EFC41090.1 - 1.6e-21 76.0 4.5 1.2e-10 41.2 0.0 4.5 4 0 0 4 4 4 4 Galactose oxidase, central domain BTB PF00651.31 EFC41090.1 - 7.5e-20 71.2 5.1 2.7e-11 43.7 0.7 3.5 2 1 1 3 3 3 2 BTB/POZ domain Kelch_5 PF13854.6 EFC41090.1 - 1e-17 63.7 11.3 5.8e-10 38.9 0.1 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFC41090.1 - 9.6e-14 51.3 4.2 0.00015 21.9 0.0 4.6 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC41090.1 - 1.4e-10 41.0 11.0 8.3e-07 29.1 0.1 4.7 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFC41090.1 - 5.5e-07 29.3 8.2 2.4e-05 24.1 0.1 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFC41090.1 - 6.2e-06 25.7 11.9 1.5e-05 24.5 0.0 4.8 5 0 0 5 5 5 1 Kelch motif BACK PF07707.15 EFC41090.1 - 0.03 14.4 0.1 0.12 12.5 0.1 2.0 1 0 0 1 1 1 0 BTB And C-terminal Kelch Ank_2 PF12796.7 EFC41091.1 - 3.7e-16 59.5 5.5 8.4e-07 29.5 0.1 4.7 3 2 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC41091.1 - 2.1e-13 50.5 0.6 0.00086 19.8 0.1 4.4 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC41091.1 - 1.1e-08 34.6 2.7 0.26 12.0 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFC41091.1 - 1.5e-08 34.7 0.9 0.089 13.1 0.1 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC41091.1 - 0.0095 16.4 3.7 5.3 7.7 0.0 4.2 5 0 0 5 5 5 1 Ankyrin repeat Pkinase PF00069.25 EFC41092.1 - 3.4e-46 157.8 0.0 6.3e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41092.1 - 8.5e-37 126.8 0.0 4.5e-33 114.6 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase NHL PF01436.21 EFC41092.1 - 1.7e-22 78.2 18.0 6e-05 22.9 0.1 9.9 9 0 0 9 9 9 4 NHL repeat EGF_2 PF07974.13 EFC41092.1 - 2e-07 31.3 46.9 0.0031 17.8 9.5 3.7 3 0 0 3 3 3 3 EGF-like domain Haspin_kinase PF12330.8 EFC41092.1 - 0.0019 17.2 0.0 0.0043 16.1 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain EGF PF00008.27 EFC41092.1 - 0.0055 17.0 24.7 0.029 14.7 4.6 3.7 3 0 0 3 3 3 2 EGF-like domain SGL PF08450.12 EFC41092.1 - 0.015 14.9 0.3 14 5.2 0.0 4.7 4 2 0 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region Kinase-like PF14531.6 EFC41092.1 - 0.043 13.1 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFC41092.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family R_equi_Vir PF05526.11 EFC41092.1 - 0.071 13.0 1.7 0.37 10.6 0.1 2.4 2 0 0 2 2 2 0 Rhodococcus equi virulence-associated protein Kdo PF06293.14 EFC41092.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family hEGF PF12661.7 EFC41092.1 - 0.22 12.2 32.8 0.73 10.6 4.1 3.9 3 0 0 3 3 3 0 Human growth factor-like EGF cEGF PF12662.7 EFC41092.1 - 1.1 9.3 14.4 31 4.6 2.0 4.1 3 0 0 3 3 3 0 Complement Clr-like EGF-like Ras PF00071.22 EFC41093.1 - 5e-22 78.2 0.2 2e-21 76.3 0.2 1.9 1 1 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 EFC41093.1 - 8.1e-09 35.6 0.2 8.6e-05 22.5 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase Roc PF08477.13 EFC41093.1 - 4.6e-08 33.3 0.0 1.3e-06 28.6 0.0 2.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41093.1 - 6.8e-07 28.9 0.2 5.6e-05 22.7 0.5 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC41093.1 - 7.8e-07 28.8 0.1 2.3e-06 27.3 0.1 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SpoOE-like PF09388.10 EFC41093.1 - 0.0076 16.1 0.8 0.026 14.4 0.8 2.0 1 0 0 1 1 1 1 Spo0E like sporulation regulatory protein F-box-like PF12937.7 EFC41093.1 - 0.15 12.0 0.0 0.36 10.7 0.0 1.7 1 0 0 1 1 1 0 F-box-like NRN1 PF15056.6 EFC41094.1 - 0.071 13.2 0.2 0.58 10.3 0.1 2.6 2 0 0 2 2 2 0 Neuritin protein family RsgA_GTPase PF03193.16 EFC41094.1 - 0.089 12.7 0.0 0.36 10.7 0.0 2.0 1 0 0 1 1 1 0 RsgA GTPase TTL PF03133.15 EFC41096.1 - 6.6e-73 245.4 0.0 1.3e-72 244.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFC41096.1 - 2.3e-07 30.3 0.0 7.3e-05 22.1 0.0 2.6 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFC41096.1 - 3.6e-07 29.7 0.0 0.0011 18.3 0.0 2.5 3 0 0 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EFC41096.1 - 0.00067 19.7 0.0 0.0091 16.1 0.0 2.6 2 1 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 EFC41096.1 - 0.039 13.5 0.0 0.46 10.1 0.0 2.2 2 0 0 2 2 2 0 RimK-like ATP-grasp domain UPF0113_N PF17833.1 EFC41097.1 - 1.7e-26 92.5 2.5 2.6e-26 92.0 2.5 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 EFC41097.1 - 2e-25 88.9 0.0 4e-25 87.9 0.0 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 EFC41097.1 - 0.00076 19.4 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 PUA domain Acetyltransf_1 PF00583.25 EFC41104.1 - 4.9e-14 52.6 0.0 6.1e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC41104.1 - 5.3e-10 39.6 0.0 8.4e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC41104.1 - 2e-09 37.4 0.0 2.7e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC41104.1 - 0.00017 21.5 0.1 0.00028 20.8 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 EFC41104.1 - 0.0016 18.2 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_3 PF13302.7 EFC41104.1 - 0.006 17.3 0.0 0.0072 17.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC41104.1 - 0.019 15.1 0.1 0.025 14.7 0.1 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 EFC41104.1 - 0.022 14.7 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Rhabdo_ncap_2 PF03216.13 EFC41104.1 - 0.034 13.6 0.1 0.049 13.1 0.1 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein Acetyltransf_15 PF17013.5 EFC41104.1 - 0.059 12.8 0.1 0.096 12.1 0.1 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase DUF4635 PF15466.6 EFC41104.1 - 0.064 12.8 0.1 0.099 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Peptidase_C97 PF05903.14 EFC41105.1 - 0.007 16.2 0.1 0.016 15.1 0.1 1.6 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF4600 PF15372.6 EFC41107.1 - 0.062 13.7 23.9 0.043 14.3 19.2 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4600) PIN_8 PF18476.1 EFC41107.1 - 0.29 11.0 18.2 0.051 13.4 8.6 2.0 1 1 1 2 2 2 0 PIN like domain SepSecS PF05889.13 EFC41107.1 - 0.78 8.4 7.7 1.1 7.9 7.7 1.3 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DUF2802 PF10975.8 EFC41107.1 - 0.91 9.7 7.8 0.11 12.6 0.9 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2802) Fib_alpha PF08702.10 EFC41107.1 - 0.92 9.7 14.2 0.25 11.5 9.3 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TarH PF02203.15 EFC41107.1 - 1 9.3 13.9 2.4 8.0 0.9 2.7 1 1 2 3 3 3 0 Tar ligand binding domain homologue DUF948 PF06103.11 EFC41107.1 - 1.4 9.2 10.1 12 6.2 3.0 3.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF5320 PF17253.2 EFC41107.1 - 6.9 7.8 5.8 13 7.0 0.7 2.6 1 1 0 2 2 2 0 Family of unknown function (DUF5320) Prefoldin_2 PF01920.20 EFC41107.1 - 8.5 6.4 19.9 21 5.1 12.9 3.2 2 1 1 3 3 3 0 Prefoldin subunit Syntaxin-6_N PF09177.11 EFC41107.1 - 9.7 6.8 15.1 2.4 8.8 2.5 2.8 1 1 2 3 3 3 0 Syntaxin 6, N-terminal Fer2 PF00111.27 EFC41108.1 - 0.024 14.6 0.1 0.047 13.6 0.1 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain DASH_Spc34 PF08657.10 EFC41109.1 - 0.071 12.9 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Tox-PLDMTX PF15645.6 EFC41109.1 - 0.097 12.9 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold Ig_mannosidase PF17753.1 EFC41110.1 - 1.4e-12 47.1 0.1 3.9e-12 45.8 0.1 1.8 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2 PF00703.21 EFC41110.1 - 4.3e-06 27.4 0.1 2.6e-05 24.9 0.0 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 EFC41110.1 - 6.5e-06 26.2 0.0 3e-05 24.0 0.0 2.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Mannosidase_ig PF17786.1 EFC41110.1 - 0.0002 21.9 0.0 0.00054 20.5 0.0 1.8 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_C PF02836.17 EFC41110.1 - 0.00022 20.5 2.3 0.001 18.3 2.4 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Pkinase PF00069.25 EFC41111.1 - 1e-44 152.9 0.7 1.7e-44 152.2 0.7 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41111.1 - 2.2e-27 96.0 1.4 2.6e-27 95.8 0.4 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC41111.1 - 0.0017 17.2 0.1 0.0025 16.7 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase SGL PF08450.12 EFC41111.1 - 0.0079 15.8 0.0 0.43 10.1 0.0 2.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Kdo PF06293.14 EFC41111.1 - 0.17 11.2 0.1 0.51 9.7 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Peptidase_S41 PF03572.18 EFC41114.1 - 6.8e-06 25.7 0.0 1.6e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase family S41 Ephrin_rec_like PF07699.13 EFC41114.1 - 0.16 11.8 9.1 0.076 12.8 6.6 1.9 1 1 0 1 1 1 0 Putative ephrin-receptor like FCD PF07729.12 EFC41114.1 - 0.23 11.9 0.0 0.43 11.0 0.0 1.3 1 0 0 1 1 1 0 FCD domain NCD3G PF07562.14 EFC41114.1 - 5 7.2 7.6 1.1 9.3 3.0 2.3 1 1 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR IPK PF03770.16 EFC41115.1 - 2.8e-42 144.8 1.3 7.5e-42 143.4 1.3 1.7 1 1 0 1 1 1 1 Inositol polyphosphate kinase DUF898 PF05987.13 EFC41116.1 - 0.0063 15.6 7.5 0.27 10.3 0.1 3.2 3 1 0 3 3 3 2 Bacterial protein of unknown function (DUF898) DUF728 PF05304.12 EFC41116.1 - 0.44 10.4 3.2 0.57 10.0 2.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF728) ABC_membrane PF00664.23 EFC41117.1 - 1.1e-75 254.9 40.4 9.7e-44 150.1 11.3 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFC41117.1 - 1.8e-52 177.5 0.2 5.6e-30 104.6 0.0 3.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFC41117.1 - 2.2e-13 50.1 4.5 0.00014 21.4 0.4 4.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFC41117.1 - 8.7e-08 32.2 0.8 0.0085 16.2 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC41117.1 - 1.5e-06 27.9 0.2 0.086 12.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 EFC41117.1 - 3.7e-06 27.6 1.0 0.00059 20.4 0.8 4.8 4 1 0 4 4 3 2 AAA domain AAA_21 PF13304.6 EFC41117.1 - 4.2e-06 26.8 0.4 0.09 12.6 0.0 3.5 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC41117.1 - 1.7e-05 24.8 0.1 0.098 12.6 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 EFC41117.1 - 4.2e-05 24.0 0.1 0.26 11.7 0.0 3.0 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 EFC41117.1 - 0.00037 20.8 1.2 0.23 11.8 0.1 3.5 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFC41117.1 - 0.0005 19.8 3.7 1.2 8.8 0.0 3.8 3 1 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EFC41117.1 - 0.00052 19.3 0.4 0.053 12.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 EFC41117.1 - 0.00086 18.6 0.3 0.12 11.6 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin Roc PF08477.13 EFC41117.1 - 0.00092 19.4 0.4 1.8 8.8 0.0 3.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 EFC41117.1 - 0.0012 18.8 0.5 1.3 8.9 0.1 2.6 2 0 0 2 2 2 2 NACHT domain DUF815 PF05673.13 EFC41117.1 - 0.0015 17.8 0.1 0.72 9.0 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_15 PF13175.6 EFC41117.1 - 0.0017 18.1 16.9 0.085 12.6 0.0 4.8 4 1 1 5 5 5 2 AAA ATPase domain RNA_helicase PF00910.22 EFC41117.1 - 0.0024 18.2 0.5 1.2 9.5 0.0 3.7 4 0 0 4 4 3 1 RNA helicase AAA PF00004.29 EFC41117.1 - 0.0043 17.5 0.1 0.62 10.5 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 EFC41117.1 - 0.0062 15.6 0.1 0.45 9.5 0.0 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 EFC41117.1 - 0.0078 15.7 0.4 1.8 8.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region cobW PF02492.19 EFC41117.1 - 0.0089 15.6 2.2 0.55 9.8 0.1 3.0 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain RAMPs PF03787.15 EFC41117.1 - 0.0096 16.0 0.1 7 6.6 0.2 3.2 2 1 0 2 2 2 0 RAMP superfamily T2SSE PF00437.20 EFC41117.1 - 0.011 14.8 0.1 3.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 EFC41117.1 - 0.016 14.6 0.0 6.4 6.1 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_14 PF13173.6 EFC41117.1 - 0.023 14.7 0.2 8.1 6.5 0.0 3.5 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.6 EFC41117.1 - 0.039 14.5 2.9 3.6 8.1 0.1 3.7 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 EFC41117.1 - 0.046 13.5 1.0 0.98 9.2 0.2 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EFC41117.1 - 0.055 13.6 0.0 9.4 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EFC41117.1 - 0.077 12.6 0.1 0.44 10.2 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_27 PF13514.6 EFC41117.1 - 0.082 12.5 1.3 0.8 9.3 0.0 2.8 3 0 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 EFC41117.1 - 0.09 11.7 0.9 1.6 7.5 0.1 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF87 PF01935.17 EFC41117.1 - 0.098 12.7 0.0 0.098 12.7 0.0 3.9 4 0 0 4 4 3 0 Helicase HerA, central domain Ploopntkinase3 PF18751.1 EFC41117.1 - 0.13 12.2 0.1 9.6 6.1 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MobB PF03205.14 EFC41117.1 - 0.14 12.0 0.9 14 5.6 0.1 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 EFC41117.1 - 0.26 11.3 1.5 23 5.0 0.0 3.2 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 EFC41117.1 - 0.51 10.2 3.6 9.1 6.2 0.1 3.4 3 0 0 3 3 3 0 NTPase ATP_bind_1 PF03029.17 EFC41117.1 - 0.89 9.3 3.4 7.8 6.2 0.1 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein Myc_N PF01056.18 EFC41117.1 - 4.7 7.0 14.3 6 6.7 0.5 2.3 2 0 0 2 2 2 0 Myc amino-terminal region DUF4476 PF14771.6 EFC41118.1 - 1.7e-24 86.0 2.2 3.9e-18 65.6 0.3 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) InPase PF18823.1 EFC41118.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Inorganic Pyrophosphatase HYR PF02494.16 EFC41118.1 - 0.11 12.9 1.8 0.54 10.6 0.3 2.7 3 1 0 3 3 3 0 HYR domain FAM75 PF14650.6 EFC41118.1 - 1 8.9 14.1 2.4 7.6 14.1 1.6 1 0 0 1 1 1 0 FAM75 family EGF_2 PF07974.13 EFC41119.1 - 5.9e-06 26.6 5.8 1.7e-05 25.1 5.8 1.9 1 0 0 1 1 1 1 EGF-like domain Fibrinogen_C PF00147.18 EFC41119.1 - 0.00017 21.5 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain F-box-like PF12937.7 EFC41119.1 - 0.00037 20.3 0.1 0.014 15.3 0.1 2.8 2 0 0 2 2 2 1 F-box-like Ank_4 PF13637.6 EFC41119.1 - 0.023 15.3 0.5 85 3.9 0.0 4.5 5 0 0 5 5 5 0 Ankyrin repeats (many copies) DUF4589 PF15252.6 EFC41120.1 - 0.0043 17.1 1.4 0.0069 16.4 1.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4589) Sel1 PF08238.12 EFC41121.1 - 2e-48 161.7 29.8 1.8e-08 34.8 0.4 8.3 8 0 0 8 8 8 7 Sel1 repeat ANAPC3 PF12895.7 EFC41121.1 - 0.0093 16.2 2.2 9.6 6.5 0.1 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFC41121.1 - 0.5 10.5 3.5 24 5.2 0.0 4.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41121.1 - 8.6 6.7 9.9 50 4.3 0.0 5.5 4 2 1 6 6 6 0 Tetratricopeptide repeat Trypan_PARP PF05887.11 EFC41122.1 - 1.3e-07 31.6 78.4 0.00032 20.7 37.3 2.2 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Complex1_LYR PF05347.15 EFC41123.1 - 3.9e-10 39.6 1.3 4.2e-05 23.5 0.8 2.3 2 0 0 2 2 2 2 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFC41123.1 - 0.00014 22.6 0.2 0.00025 21.7 0.2 1.5 1 0 0 1 1 1 1 Complex1_LYR-like Activator_LAG-3 PF11498.8 EFC41124.1 - 0.00079 18.5 4.4 0.0017 17.4 4.4 1.5 1 0 0 1 1 1 1 Transcriptional activator LAG-3 DUF4303 PF14136.6 EFC41125.1 - 0.03 14.1 1.5 0.04 13.7 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) FmdE PF02663.14 EFC41125.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Nab2 PF11517.8 EFC41125.1 - 0.066 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Membralin PF09746.9 EFC41125.1 - 0.094 11.7 2.5 0.12 11.4 2.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein Acetyltransf_2 PF00797.17 EFC41126.1 - 4.2e-38 131.5 0.0 6e-37 127.7 0.0 2.2 1 1 0 1 1 1 1 N-acetyltransferase LRR_6 PF13516.6 EFC41127.1 - 1.5e-32 108.9 50.7 0.0016 18.3 0.0 15.5 15 0 0 15 15 15 11 Leucine Rich repeat LRR_8 PF13855.6 EFC41127.1 - 1.1e-23 82.8 42.0 2.3e-06 27.3 0.2 8.3 4 2 3 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC41127.1 - 6.4e-23 80.5 60.2 0.003 17.9 0.2 10.6 3 2 6 12 12 12 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41127.1 - 5.8e-10 38.3 49.8 1.7 9.5 0.4 14.9 14 2 2 16 16 16 5 Leucine Rich Repeat F-box PF00646.33 EFC41127.1 - 1.8e-05 24.5 1.4 6.9e-05 22.6 1.4 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC41127.1 - 7.4e-05 22.6 2.3 0.00018 21.4 2.3 1.6 1 0 0 1 1 1 1 F-box-like DUF4116 PF13475.6 EFC41128.1 - 6.1e-22 77.1 8.4 1.2e-13 50.6 0.1 5.3 5 0 0 5 5 5 4 Domain of unknown function (DUF4116) DUF2018 PF09442.10 EFC41128.1 - 0.086 13.8 1.5 0.35 11.9 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2018) PBS_linker_poly PF00427.21 EFC41129.1 - 4.8e-20 71.9 0.5 6.4e-15 55.3 0.0 2.1 1 1 1 2 2 2 2 Phycobilisome Linker polypeptide DUF4214 PF13946.6 EFC41129.1 - 2.3e-09 37.2 0.1 1.5e-06 28.2 0.0 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF4214) C2 PF00168.30 EFC41131.1 - 1.3e-21 76.8 0.0 2.7e-21 75.8 0.0 1.5 1 0 0 1 1 1 1 C2 domain Peptidase_C92 PF05708.12 EFC41131.1 - 1.3e-06 28.6 0.0 0.039 14.1 0.0 2.3 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family FBA_2 PF07735.17 EFC41132.1 - 0.089 12.9 1.6 0.27 11.4 1.6 1.8 1 0 0 1 1 1 0 F-box associated DNA_pol_A_exo1 PF01612.20 EFC41133.1 - 2.4e-41 141.4 0.2 4.5e-41 140.5 0.2 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 EFC41133.1 - 1.8e-13 50.9 0.4 1.8e-13 50.9 0.4 3.8 3 1 0 3 3 3 1 PMC2NT (NUC016) domain HRDC PF00570.23 EFC41133.1 - 5.7e-13 48.7 0.0 1.2e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 HRDC domain TFIIA PF03153.13 EFC41133.1 - 0.8 9.6 25.5 1.2 9.0 5.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Med24_N PF11277.8 EFC41133.1 - 1.7 6.6 4.7 3 5.8 4.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal DNA_pol_E_B PF04042.16 EFC41134.1 - 2.7e-28 98.8 0.9 4e-28 98.2 0.9 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 EFC41134.1 - 0.031 14.3 1.2 0.058 13.3 1.2 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Metallophos_3 PF14582.6 EFC41134.1 - 0.044 13.1 0.4 2 7.7 0.0 2.9 3 0 0 3 3 3 0 Metallophosphoesterase, calcineurin superfamily Rep_fac-A_C PF08646.10 EFC41135.1 - 2.6e-16 59.7 1.1 5.9e-16 58.5 1.1 1.6 1 0 0 1 1 1 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EFC41135.1 - 8.1e-13 48.1 3.1 7.2e-11 41.9 1.9 2.6 2 0 0 2 2 2 2 Replication protein A OB domain TF_Zn_Ribbon PF08271.12 EFC41135.1 - 0.016 14.7 1.3 0.044 13.3 1.3 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding TFIIA PF03153.13 EFC41135.1 - 0.067 13.2 14.7 0.099 12.6 14.7 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 EFC41135.1 - 3.4 6.3 5.6 5.7 5.6 5.6 1.3 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 EFC41135.1 - 8 5.0 9.1 12 4.4 9.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNA_lig_T4_1 PF09511.10 EFC41136.1 - 4.6e-30 105.1 1.8 4.6e-30 105.1 1.8 1.6 2 0 0 2 2 2 1 RNA ligase DUF3486 PF11985.8 EFC41136.1 - 0.032 14.7 0.2 0.055 13.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) Meis_PKNOX_N PF16493.5 EFC41136.1 - 0.051 13.9 0.3 0.16 12.3 0.1 2.0 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 FapA PF03961.13 EFC41136.1 - 0.094 11.3 1.9 0.13 10.8 1.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3931 PF13082.6 EFC41136.1 - 0.095 12.9 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3931) Metallophos PF00149.28 EFC41137.1 - 3.3e-08 34.3 0.4 8.7e-08 32.9 0.4 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pkinase PF00069.25 EFC41138.1 - 3.4e-21 75.8 1.0 4.6e-21 75.4 1.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41138.1 - 9.4e-16 57.9 0.1 1.4e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 EFC41138.1 - 6e-13 49.0 0.1 1.5e-12 47.7 0.0 1.7 2 0 0 2 2 2 1 C2 domain Kinase-like PF14531.6 EFC41138.1 - 0.0011 18.4 0.2 0.37 10.1 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Kdo PF06293.14 EFC41138.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TRI5 PF06330.11 EFC41139.1 - 0.02 13.7 0.3 0.031 13.1 0.3 1.3 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) Thioredox_DsbH PF03190.15 EFC41140.1 - 1.8e-77 258.9 0.1 4e-77 257.7 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 EFC41140.1 - 1.2e-12 47.8 0.0 2.4e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_76 PF03663.14 EFC41140.1 - 0.0014 18.2 1.6 0.02 14.4 0.2 2.1 2 0 0 2 2 2 1 Glycosyl hydrolase family 76 GlcNAc_2-epim PF07221.11 EFC41140.1 - 0.0026 17.1 0.0 0.083 12.1 0.0 2.2 2 0 0 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Thioredoxin_2 PF13098.6 EFC41140.1 - 0.013 16.0 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain C5-epim_C PF06662.13 EFC41140.1 - 0.12 11.9 3.9 1.2 8.6 0.2 3.5 3 2 1 4 4 4 0 D-glucuronyl C5-epimerase C-terminus RdRP PF05183.12 EFC41141.1 - 2.6e-16 59.4 0.2 1.3e-11 43.9 0.1 2.5 2 0 0 2 2 2 2 RNA dependent RNA polymerase Methyltransf_32 PF13679.6 EFC41142.1 - 5.3e-31 107.7 2.8 9.6e-31 106.9 2.8 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF1351 PF07083.11 EFC41142.1 - 0.036 13.8 2.4 0.049 13.4 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) GrpE PF01025.19 EFC41142.1 - 0.18 11.4 1.9 0.29 10.8 0.0 2.1 2 1 0 2 2 2 0 GrpE Alginate_lyase PF05426.12 EFC41143.1 - 0.04 13.5 0.1 0.051 13.1 0.1 1.1 1 0 0 1 1 1 0 Alginate lyase DUF4476 PF14771.6 EFC41144.1 - 3e-22 78.7 1.1 1.5e-17 63.6 0.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) EF-hand_8 PF13833.6 EFC41144.1 - 0.0028 17.5 0.1 0.033 14.0 0.2 2.2 1 1 1 2 2 2 1 EF-hand domain pair Pkinase_Tyr PF07714.17 EFC41145.1 - 3.1e-44 151.2 0.2 1.7e-41 142.2 0.1 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC41145.1 - 1.9e-43 148.8 0.2 3.7e-43 147.8 0.2 1.5 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFC41145.1 - 0.00085 19.3 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC41145.1 - 0.00094 18.2 0.1 0.0026 16.8 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain DUF2371 PF10177.9 EFC41145.1 - 0.062 13.5 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) SNase PF00565.17 EFC41148.1 - 6.7e-21 74.8 2.7 1.2e-20 74.0 1.8 1.9 2 1 0 2 2 2 1 Staphylococcal nuclease homologue SNAP-25 PF00835.19 EFC41148.1 - 0.65 10.3 0.0 0.65 10.3 0.0 2.7 3 0 0 3 3 3 0 SNAP-25 family Serpin PF00079.20 EFC41149.1 - 9.1e-87 291.8 9.8 1e-86 291.6 9.8 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) YfkD PF14167.6 EFC41149.1 - 0.0039 16.4 3.2 0.0039 16.4 3.2 2.5 2 1 1 3 3 3 1 YfkD-like protein NHL PF01436.21 EFC41150.1 - 1.8e-118 381.0 0.0 1.1e-07 31.5 0.0 17.1 17 0 0 17 17 17 16 NHL repeat EGF_2 PF07974.13 EFC41150.1 - 1.5e-38 130.8 227.5 0.00028 21.2 9.0 14.2 13 1 1 14 14 14 13 EGF-like domain Pkinase PF00069.25 EFC41150.1 - 1.6e-33 116.2 0.9 3.1e-33 115.3 0.9 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41150.1 - 2.5e-20 72.9 0.2 4.3e-20 72.1 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SGL PF08450.12 EFC41150.1 - 8e-13 48.5 14.3 0.00034 20.3 0.2 7.7 4 2 5 9 9 9 3 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC41150.1 - 8.5e-05 22.6 1.2 66 3.3 0.0 7.1 7 1 0 7 7 7 0 Esterase-like activity of phytase DUF1398 PF07166.11 EFC41150.1 - 0.00047 20.2 10.5 0.51 10.4 0.1 6.9 4 3 5 10 10 10 1 Protein of unknown function (DUF1398) Pkinase_fungal PF17667.1 EFC41150.1 - 0.012 14.4 0.2 0.02 13.7 0.2 1.2 1 0 0 1 1 1 0 Fungal protein kinase TMEM154 PF15102.6 EFC41150.1 - 0.027 14.4 0.3 0.085 12.8 0.3 1.9 1 0 0 1 1 1 0 TMEM154 protein family YajC PF02699.15 EFC41150.1 - 0.038 13.9 0.6 0.098 12.6 0.6 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit Blt1 PF12754.7 EFC41150.1 - 0.11 12.8 0.2 0.24 11.7 0.2 1.5 1 0 0 1 1 1 0 Blt1 N-terminal domain Kdo PF06293.14 EFC41150.1 - 0.13 11.6 0.1 0.22 10.8 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arylesterase PF01731.20 EFC41150.1 - 1.7 8.9 18.6 1.7 8.9 0.1 8.1 8 1 1 9 9 9 0 Arylesterase DUF5638 PF18688.1 EFC41151.1 - 0.13 12.5 0.1 0.3 11.4 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5638) PP2C PF00481.21 EFC41152.1 - 1.2e-43 149.7 0.0 1.6e-43 149.3 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Mito_carr PF00153.27 EFC41153.1 - 4e-60 199.8 4.4 2.2e-20 72.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Bac_export_2 PF01312.19 EFC41153.1 - 0.066 12.4 0.1 0.13 11.4 0.0 1.5 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family LRR_8 PF13855.6 EFC41154.1 - 0.0026 17.5 4.8 0.0033 17.2 2.8 2.2 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EFC41154.1 - 0.0043 17.4 12.5 0.041 14.3 6.2 3.7 1 1 2 4 4 4 3 Leucine Rich repeats (2 copies) C2 PF00168.30 EFC41155.1 - 4e-17 62.4 0.0 9.1e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 C2 domain LRR_8 PF13855.6 EFC41156.1 - 8.3e-14 51.1 1.8 0.00025 20.7 0.0 4.6 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC41156.1 - 2.1e-10 40.7 13.9 0.00081 19.7 0.0 7.1 6 1 2 8 8 8 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC41156.1 - 0.001 19.0 3.4 3.4 8.0 0.0 5.3 4 0 0 4 4 4 1 Leucine Rich repeat LRR_1 PF00560.33 EFC41156.1 - 0.0015 18.8 9.4 3.7 8.5 0.0 7.0 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC41156.1 - 0.0047 16.5 0.3 0.027 14.0 0.2 2.3 1 1 0 1 1 1 1 Leucine-rich repeat Trm56 PF01994.16 EFC41156.1 - 0.013 15.5 0.1 0.32 10.9 0.1 2.5 2 0 0 2 2 2 0 tRNA ribose 2'-O-methyltransferase, aTrm56 Acid_PPase PF12689.7 EFC41156.1 - 0.038 13.8 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Acid Phosphatase DUF3885 PF13021.6 EFC41156.1 - 0.07 13.3 0.3 0.24 11.5 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) NosD PF05048.13 EFC41156.1 - 4.6 6.4 9.0 0.43 9.8 0.7 2.5 3 0 0 3 3 3 0 Periplasmic copper-binding protein (NosD) SNF2_N PF00176.23 EFC41157.1 - 3.9e-56 190.3 0.3 8.3e-56 189.2 0.3 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC41157.1 - 1.7e-18 67.0 0.0 3.8e-15 56.2 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DUF2439 PF10382.9 EFC41157.1 - 4.4e-08 33.3 1.6 2.5e-07 30.9 1.6 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) ERCC3_RAD25_C PF16203.5 EFC41157.1 - 7.5e-05 22.1 0.1 7.5e-05 22.1 0.1 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Ras PF00071.22 EFC41158.1 - 2.3e-67 225.6 0.5 2.7e-67 225.4 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41158.1 - 2.6e-37 127.7 0.1 4.6e-37 126.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41158.1 - 2.3e-17 63.0 0.1 2.8e-17 62.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC41158.1 - 1.8e-06 27.5 0.1 2.2e-06 27.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFC41158.1 - 9.5e-06 25.6 0.6 0.12 12.2 0.1 2.4 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC41158.1 - 1.5e-05 24.6 0.2 4.8e-05 23.0 0.1 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC41158.1 - 2.2e-05 24.0 0.1 2.8e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC41158.1 - 7.7e-05 22.7 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA PF00004.29 EFC41158.1 - 0.005 17.3 0.0 0.068 13.6 0.0 2.1 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC41158.1 - 0.015 15.7 0.0 0.023 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain FeoB_N PF02421.18 EFC41158.1 - 0.029 13.9 0.0 0.26 10.8 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_7 PF12775.7 EFC41158.1 - 0.054 13.0 0.1 0.23 11.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region PduV-EutP PF10662.9 EFC41158.1 - 0.057 13.2 0.2 1.1 8.9 0.0 2.3 2 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 EFC41158.1 - 0.058 13.4 0.1 0.13 12.3 0.0 1.9 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC41158.1 - 0.059 13.6 0.0 0.13 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC41158.1 - 0.061 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Septin PF00735.18 EFC41158.1 - 0.069 12.4 0.0 0.17 11.2 0.0 1.6 2 0 0 2 2 2 0 Septin LANC_like PF05147.13 EFC41158.1 - 0.095 11.3 0.0 0.21 10.1 0.0 1.5 1 1 0 1 1 1 0 Lanthionine synthetase C-like protein TniB PF05621.11 EFC41158.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein NRN1 PF15056.6 EFC41159.1 - 0.018 15.2 0.1 0.035 14.2 0.1 1.5 1 0 0 1 1 1 0 Neuritin protein family F-box PF00646.33 EFC41159.1 - 0.028 14.3 0.2 0.066 13.1 0.2 1.7 1 0 0 1 1 1 0 F-box domain Asp2 PF16929.5 EFC41159.1 - 0.04 12.9 0.2 0.052 12.5 0.2 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter DUF1870 PF08965.10 EFC41159.1 - 0.052 13.6 0.1 0.12 12.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) DUF1841 PF08897.11 EFC41159.1 - 0.13 12.3 0.7 8.5 6.4 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1841) Arf PF00025.21 EFC41160.1 - 2.3e-65 219.3 0.1 2.5e-65 219.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC41160.1 - 7.5e-14 51.6 0.0 8.3e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC41160.1 - 1.4e-13 50.7 1.3 5.5e-11 42.2 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC41160.1 - 5.4e-13 48.8 0.1 6.7e-13 48.5 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC41160.1 - 2.1e-12 47.3 0.2 3e-12 46.8 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC41160.1 - 4.9e-09 35.9 0.1 6.3e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC41160.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1015 PF06245.11 EFC41160.1 - 0.068 12.0 0.1 0.083 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) DUF3913 PF13052.6 EFC41160.1 - 0.1 12.9 0.0 1.6 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3913) Vmethyltransf PF01660.17 EFC41160.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase NHL PF01436.21 EFC41162.1 - 6.3e-29 98.5 13.4 9.6e-07 28.5 0.0 6.2 7 0 0 7 7 7 5 NHL repeat DUF5128 PF17170.4 EFC41162.1 - 3.1e-14 52.9 8.0 7e-06 25.4 0.6 3.9 3 1 1 4 4 4 3 6-bladed beta-propeller SGL PF08450.12 EFC41162.1 - 7.9e-10 38.7 0.8 2.3e-05 24.1 0.1 4.4 2 2 2 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EFC41162.1 - 1.2e-05 25.2 4.8 0.0075 16.2 0.2 4.3 4 0 0 4 4 4 2 Beta-propeller repeat DUF4934 PF16288.5 EFC41162.1 - 0.0029 17.5 0.8 0.026 14.4 0.0 2.9 4 1 0 4 4 4 1 Domain of unknown function (DUF4934) Arylesterase PF01731.20 EFC41162.1 - 0.0047 17.1 0.9 6.4 7.1 0.0 4.4 5 0 0 5 5 5 1 Arylesterase Phytase-like PF13449.6 EFC41162.1 - 0.035 14.1 0.0 2.8 7.8 0.0 2.5 2 1 0 2 2 2 0 Esterase-like activity of phytase WD40 PF00400.32 EFC41164.1 - 8.6e-18 64.4 10.7 0.03 15.2 0.1 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat BTB PF00651.31 EFC41164.1 - 8.1e-10 38.9 2.5 9.8e-10 38.7 0.7 2.0 2 0 0 2 2 2 1 BTB/POZ domain Kelch_6 PF13964.6 EFC41164.1 - 3.7e-08 33.4 6.2 0.44 10.9 0.0 6.1 5 1 1 6 6 6 3 Kelch motif BACK PF07707.15 EFC41164.1 - 0.00035 20.6 0.9 0.0025 17.9 0.9 2.3 1 1 0 1 1 1 1 BTB And C-terminal Kelch Nup160 PF11715.8 EFC41164.1 - 0.0011 17.8 7.8 0.5 8.9 0.0 5.2 4 2 1 5 5 5 2 Nucleoporin Nup120/160 Sel1 PF08238.12 EFC41167.1 - 5.6e-91 296.9 35.5 2e-10 41.0 0.1 10.1 10 0 0 10 10 10 10 Sel1 repeat TPR_16 PF13432.6 EFC41167.1 - 3.4e-05 24.4 4.9 6.4 7.5 0.1 5.5 5 1 1 6 6 6 1 Tetratricopeptide repeat Esterase PF00756.20 EFC41167.1 - 0.043 13.5 0.9 0.22 11.1 0.1 2.2 2 0 0 2 2 2 0 Putative esterase FtsA PF14450.6 EFC41167.1 - 0.099 13.1 0.1 8.8 6.8 0.0 3.3 2 1 1 3 3 3 0 Cell division protein FtsA 23S_rRNA_IVP PF05635.11 EFC41167.1 - 0.15 12.3 3.5 9.6 6.6 0.0 3.6 4 0 0 4 4 4 0 23S rRNA-intervening sequence protein Amdo_NSP PF12475.8 EFC41167.1 - 0.16 12.0 4.3 1.2e+02 2.9 0.0 6.1 9 0 0 9 9 9 0 Amdovirus non-structural protein DUF3089 PF11288.8 EFC41167.1 - 0.31 10.6 1.9 60 3.1 0.0 4.9 7 0 0 7 7 7 0 Protein of unknown function (DUF3089) TCP PF03634.13 EFC41167.1 - 3.9 8.0 16.7 71 3.9 0.1 6.7 4 4 5 9 9 9 0 TCP family transcription factor DUF1719 PF08224.11 EFC41167.1 - 4.2 6.4 7.3 30 3.6 0.0 4.5 5 1 2 7 7 7 0 Domain of unknown function (DUF1719) DUF4296 PF14129.6 EFC41167.1 - 9.5 6.9 10.0 34 5.1 0.1 4.5 4 2 1 5 5 5 0 Domain of unknown function (DUF4296) Pkinase PF00069.25 EFC41168.1 - 9.2e-50 169.4 0.7 2.2e-49 168.2 0.7 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41168.1 - 4e-30 105.0 0.1 9.3e-30 103.8 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC41168.1 - 7.4e-27 92.0 4.7 0.0013 18.7 0.0 9.8 10 0 0 10 10 10 5 NHL repeat EGF_2 PF07974.13 EFC41168.1 - 2.9e-21 75.5 130.5 0.00074 19.8 15.3 8.7 8 0 0 8 8 8 8 EGF-like domain Pkinase_fungal PF17667.1 EFC41168.1 - 0.00014 20.8 0.0 0.00023 20.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EFC41168.1 - 0.0022 17.9 0.1 0.0063 16.4 0.1 1.7 1 0 0 1 1 1 1 TMEM154 protein family TGT PF01702.18 EFC41168.1 - 0.14 11.2 2.3 0.24 10.5 0.4 2.2 1 1 1 2 2 2 0 Queuine tRNA-ribosyltransferase VirC1 PF07015.11 EFC41168.1 - 0.89 8.8 2.6 1.2 8.3 0.2 2.4 3 0 0 3 3 3 0 VirC1 protein Sde2_N_Ubi PF13019.6 EFC41168.1 - 5.8 6.7 4.9 1.8 8.4 0.0 2.7 3 0 0 3 3 3 0 Silencing defective 2 N-terminal ubiquitin domain Herpes_LMP1 PF05297.11 EFC41169.1 - 0.065 12.4 3.9 0.067 12.4 3.9 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sensor PF13796.6 EFC41169.1 - 0.7 9.9 8.1 0.48 10.5 6.8 1.4 1 1 0 1 1 1 0 Putative sensor DUF3040 PF11239.8 EFC41169.1 - 1.7 8.9 4.8 0.33 11.3 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) Steroid_dh PF02544.16 EFC41171.1 - 1.1e-38 132.6 5.9 1.1e-38 132.6 5.9 2.0 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 EFC41171.1 - 6.5e-08 32.4 0.5 6.5e-08 32.4 0.5 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) PEMT PF04191.13 EFC41171.1 - 0.00024 21.5 4.8 0.00028 21.3 0.8 2.9 2 1 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 EFC41171.1 - 0.13 12.7 0.1 0.13 12.7 0.1 2.3 3 0 0 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Actin PF00022.19 EFC41172.1 - 1.1e-31 109.9 0.0 5.9e-21 74.6 0.0 2.5 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 EFC41172.1 - 0.091 11.6 0.0 0.2 10.5 0.0 1.5 1 0 0 1 1 1 0 MreB/Mbl protein DUF179 PF02622.15 EFC41174.1 - 6.7e-05 22.9 0.1 0.0014 18.6 0.0 2.3 1 1 1 2 2 2 1 Uncharacterized ACR, COG1678 Swm2 PF17083.5 EFC41174.1 - 0.00065 19.7 1.7 0.00081 19.4 0.5 1.7 2 0 0 2 2 2 1 Nucleolar protein Swm2 RGS PF00615.19 EFC41175.1 - 1.8e-08 34.7 1.4 4.4e-08 33.4 1.4 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain CrgA PF06781.12 EFC41175.1 - 0.46 10.6 1.5 1.2 9.3 0.3 2.3 2 0 0 2 2 2 0 Cell division protein CrgA UL42 PF17638.2 EFC41175.1 - 0.95 9.5 5.7 0.64 10.0 0.7 2.6 3 0 0 3 3 3 0 HCMV UL42 DUF1129 PF06570.11 EFC41175.1 - 9.7 5.6 10.2 37 3.7 10.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Oxidored_FMN PF00724.20 EFC41176.1 - 4.1e-88 295.9 0.0 4.8e-88 295.7 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF4021 PF13213.6 EFC41176.1 - 0.017 15.1 0.5 0.037 14.0 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) SNARE PF05739.19 EFC41177.1 - 1.6e-08 34.4 2.0 1.7e-08 34.4 0.1 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 EFC41177.1 - 6.6e-05 22.7 22.9 6.6e-05 22.7 22.9 2.1 2 0 0 2 2 2 1 Syntaxin SLED PF12140.8 EFC41177.1 - 2.3 8.8 6.8 12 6.4 0.1 2.9 2 1 0 2 2 2 0 SLED domain PARP PF00644.20 EFC41178.1 - 2e-67 226.6 0.4 2.3e-66 223.1 0.0 2.7 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 EFC41178.1 - 1.4e-36 125.6 10.3 3.8e-36 124.2 8.1 2.7 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 EFC41178.1 - 6.3e-19 67.8 1.4 6.3e-19 67.8 1.4 2.4 2 0 0 2 2 2 1 WGR domain BRCT PF00533.26 EFC41178.1 - 1.3e-14 54.3 3.1 1.3e-14 54.3 0.2 2.5 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain zf-PARP PF00645.18 EFC41178.1 - 1.7e-12 48.0 1.4 1.7e-12 48.0 1.4 3.3 4 0 0 4 4 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PTCB-BRCT PF12738.7 EFC41178.1 - 3.8e-09 36.4 0.7 1.1e-08 34.9 0.1 2.1 2 0 0 2 2 2 1 twin BRCT domain PADR1 PF08063.12 EFC41178.1 - 7.2e-08 32.1 1.0 2.7e-07 30.3 1.0 2.0 1 0 0 1 1 1 1 PADR1 (NUC008) domain BRCT_2 PF16589.5 EFC41178.1 - 4.9e-05 23.7 0.6 0.00014 22.2 0.6 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain CCDC24 PF15669.5 EFC41178.1 - 0.012 15.5 0.5 0.047 13.6 0.5 2.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family LIG3_BRCT PF16759.5 EFC41178.1 - 0.097 13.0 0.2 0.26 11.6 0.2 1.8 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Mucin-like PF16058.5 EFC41178.1 - 0.12 12.5 11.6 0.28 11.3 11.6 1.5 1 0 0 1 1 1 0 Mucin-like Med3 PF11593.8 EFC41178.1 - 0.59 9.3 6.7 1.3 8.2 6.7 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal NUDIX PF00293.28 EFC41179.1 - 1.1e-16 61.0 0.0 1.7e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF4916 PF16262.5 EFC41179.1 - 0.033 13.7 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4916) Csd3_N PF18059.1 EFC41179.1 - 0.039 14.5 0.4 0.1 13.1 0.4 1.7 1 0 0 1 1 1 0 Csd3 N-terminal MACPF PF01823.19 EFC41180.1 - 7.7e-11 42.5 0.4 1.7e-10 41.3 0.4 1.6 1 0 0 1 1 1 1 MAC/Perforin domain YccF PF03733.13 EFC41181.1 - 2.5e-17 63.3 26.6 2.5e-13 50.5 7.8 2.3 2 0 0 2 2 2 2 Inner membrane component domain DUF2207 PF09972.9 EFC41181.1 - 5.6 5.6 6.2 10 4.8 0.6 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Arm PF00514.23 EFC41182.1 - 1.9e-29 100.7 0.2 5e-05 23.2 0.0 5.4 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat WAPL PF07814.13 EFC41182.1 - 5.1e-12 45.3 0.0 2.2e-06 26.7 0.1 2.1 1 1 1 2 2 2 2 Wings apart-like protein regulation of heterochromatin Atx10homo_assoc PF09759.9 EFC41182.1 - 5e-05 23.3 0.1 1.2 9.2 0.0 3.4 1 1 3 4 4 4 3 Spinocerebellar ataxia type 10 protein domain Arm_2 PF04826.13 EFC41182.1 - 8.2e-05 22.2 0.0 0.00074 19.1 0.0 2.7 1 1 0 1 1 1 1 Armadillo-like HEAT_2 PF13646.6 EFC41182.1 - 0.00039 20.8 1.8 1.4 9.4 0.1 4.0 1 1 3 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 EFC41182.1 - 0.00065 20.1 1.8 61 4.3 0.0 5.2 4 1 1 6 6 6 0 HEAT-like repeat RICTOR_N PF14664.6 EFC41182.1 - 0.00087 18.4 0.0 0.47 9.4 0.0 2.6 2 1 0 2 2 2 2 Rapamycin-insensitive companion of mTOR, N-term HEAT PF02985.22 EFC41182.1 - 0.02 15.1 9.4 3 8.3 0.1 5.7 6 1 1 7 7 7 0 HEAT repeat DUF3361 PF11841.8 EFC41182.1 - 0.086 12.8 0.1 19 5.2 0.0 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF3361) V-ATPase_H_N PF03224.14 EFC41182.1 - 0.097 11.9 0.0 0.74 9.1 0.0 2.1 1 1 0 1 1 1 0 V-ATPase subunit H PB1 PF00564.24 EFC41182.1 - 0.15 12.0 0.1 1 9.3 0.0 2.4 2 0 0 2 2 2 0 PB1 domain Amidase PF01425.21 EFC41183.1 - 6.3e-61 206.7 0.0 5.9e-58 196.9 0.0 3.2 1 1 0 1 1 1 1 Amidase dsrm PF00035.26 EFC41184.1 - 0.00023 21.8 0.1 0.62 10.8 0.0 3.0 2 0 0 2 2 2 2 Double-stranded RNA binding motif SH3_3 PF08239.11 EFC41185.1 - 0.00057 20.1 0.3 0.00087 19.5 0.3 1.3 1 0 0 1 1 1 1 Bacterial SH3 domain Epimerase PF01370.21 EFC41187.1 - 7.6e-10 38.7 0.0 4.5e-09 36.1 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC41187.1 - 1.5e-05 24.6 0.0 0.0054 16.2 0.0 2.4 3 0 0 3 3 3 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFC41187.1 - 9.5e-05 22.4 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFC41187.1 - 0.00015 20.9 0.0 0.00036 19.6 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFC41187.1 - 0.013 14.6 0.0 0.098 11.7 0.0 2.0 1 1 0 1 1 1 0 RmlD substrate binding domain NmrA PF05368.13 EFC41187.1 - 0.13 11.8 0.0 0.42 10.1 0.0 1.8 2 0 0 2 2 2 0 NmrA-like family ABC_tran PF00005.27 EFC41188.1 - 1.2e-23 84.1 0.0 2.5e-23 83.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EFC41188.1 - 6.1e-12 45.4 11.0 1.5e-11 44.1 11.0 1.7 1 0 0 1 1 1 1 ABC-2 type transporter AAA_23 PF13476.6 EFC41188.1 - 0.00012 22.7 0.1 0.00038 21.0 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EFC41188.1 - 0.00013 21.9 0.1 0.0053 16.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC41188.1 - 0.00049 20.0 0.2 0.0013 18.7 0.2 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC41188.1 - 0.0027 17.4 0.2 0.0062 16.3 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFC41188.1 - 0.0067 15.9 0.4 0.028 13.8 0.4 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain LPG_synthase_TM PF03706.13 EFC41188.1 - 0.0098 15.5 1.3 0.018 14.6 1.3 1.3 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region AAA_16 PF13191.6 EFC41188.1 - 0.016 15.6 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFC41188.1 - 0.025 14.9 0.2 0.14 12.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC41188.1 - 0.025 15.1 0.0 0.072 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 EFC41188.1 - 0.033 14.6 0.1 0.093 13.2 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 EFC41188.1 - 0.034 13.7 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFC41188.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 EFC41188.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFC41188.1 - 0.23 11.2 0.2 0.39 10.4 0.2 1.2 1 0 0 1 1 1 0 AAA domain Kelch_1 PF01344.25 EFC41189.1 - 1.2e-36 124.0 3.4 1.4e-08 34.2 0.1 5.8 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFC41189.1 - 2.3e-26 91.6 10.2 1.4e-06 28.2 0.2 6.6 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC41189.1 - 1.3e-17 63.4 10.6 0.0011 19.2 0.0 5.8 4 2 2 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFC41189.1 - 4.8e-15 55.4 2.8 0.0015 18.8 0.0 5.7 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC41189.1 - 1.7e-14 53.4 0.7 0.00091 19.2 0.0 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFC41189.1 - 5.3e-11 42.0 5.9 0.0013 18.6 0.0 6.6 6 2 0 6 6 6 3 Kelch motif Pro-kuma_activ PF09286.11 EFC41190.1 - 2.8e-22 79.6 2.8 4e-22 79.0 0.1 2.3 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFC41190.1 - 3.4e-08 33.1 0.9 6.2e-08 32.3 0.9 1.3 1 0 0 1 1 1 1 Subtilase family LOH1CR12 PF10158.9 EFC41191.1 - 0.0055 16.7 5.4 0.016 15.2 0.1 3.0 3 0 0 3 3 3 1 Tumour suppressor protein Nif11 PF07862.11 EFC41191.1 - 3.8 7.9 5.3 2.2 8.7 0.6 2.9 3 0 0 3 3 3 0 Nif11 domain CENP-H PF05837.12 EFC41191.1 - 4 7.9 12.0 1.1 9.7 7.4 2.4 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Phi-29_GP16_7 PF06720.11 EFC41192.1 - 0.06 13.2 0.1 0.063 13.1 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Reticulon PF02453.17 EFC41194.1 - 0.0044 17.0 8.3 0.0073 16.3 8.3 1.4 1 0 0 1 1 1 1 Reticulon DUF2070 PF09843.9 EFC41194.1 - 0.48 8.7 10.6 0.58 8.4 10.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ENTH PF01417.20 EFC41194.1 - 0.8 9.8 5.9 4.4 7.4 0.4 2.6 3 0 0 3 3 3 0 ENTH domain YppG PF14179.6 EFC41194.1 - 4.7 8.0 16.4 1.4 9.6 13.3 1.8 2 0 0 2 2 2 0 YppG-like protein Arf PF00025.21 EFC41196.1 - 2.3e-65 219.3 0.1 2.5e-65 219.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC41196.1 - 7.5e-14 51.6 0.0 8.3e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC41196.1 - 1.4e-13 50.7 1.3 5.5e-11 42.2 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC41196.1 - 5.4e-13 48.8 0.1 6.7e-13 48.5 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC41196.1 - 2.1e-12 47.3 0.2 3e-12 46.8 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC41196.1 - 4.9e-09 35.9 0.1 6.3e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC41196.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1015 PF06245.11 EFC41196.1 - 0.068 12.0 0.1 0.083 11.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) DUF3913 PF13052.6 EFC41196.1 - 0.1 12.9 0.0 1.6 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3913) Vmethyltransf PF01660.17 EFC41196.1 - 0.12 11.2 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase CDC45 PF02724.14 EFC41197.1 - 0.00042 18.8 0.1 0.00049 18.5 0.1 1.1 1 0 0 1 1 1 1 CDC45-like protein TFIIF_alpha PF05793.12 EFC41197.1 - 0.01 14.5 9.3 0.014 14.0 9.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.9 EFC41197.1 - 0.11 12.1 12.4 0.17 11.4 12.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Podoplanin PF05808.11 EFC41197.1 - 0.3 11.2 3.3 0.6 10.2 3.3 1.5 1 0 0 1 1 1 0 Podoplanin FancD2 PF14631.6 EFC41197.1 - 0.68 7.3 2.5 0.89 6.9 2.5 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF4116 PF13475.6 EFC41199.1 - 0.00059 19.5 2.4 0.14 11.9 0.0 2.8 2 1 0 3 3 3 2 Domain of unknown function (DUF4116) Guanylate_cyc PF00211.20 EFC41200.1 - 7.9e-08 32.1 0.1 9.4e-07 28.6 0.0 2.3 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC41200.1 - 0.00015 21.7 7.4 0.00041 20.2 7.4 1.9 1 1 0 1 1 1 1 Cache domain Band_7_1 PF13421.6 EFC41201.1 - 0.06 13.1 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 SPFH domain-Band 7 family Peptidase_C39_2 PF13529.6 EFC41202.1 - 9.9e-12 45.6 0.1 2.6e-11 44.3 0.1 1.8 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFC41202.1 - 0.0019 18.2 0.1 0.0033 17.4 0.1 1.4 1 0 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Guanylate_cyc_2 PF09778.9 EFC41202.1 - 0.011 15.1 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 Guanylylate cyclase LAP1C PF05609.12 EFC41202.1 - 8.5 5.3 20.1 12 4.9 20.1 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2935 PF11155.8 EFC41204.1 - 0.028 14.8 2.2 0.029 14.7 1.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) DUF1461 PF07314.11 EFC41204.1 - 0.12 12.3 3.2 0.15 12.0 3.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) DUF2206 PF09971.9 EFC41204.1 - 0.23 10.2 8.8 0.27 9.9 8.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) DUF1664 PF07889.12 EFC41204.1 - 0.23 11.5 1.8 0.45 10.6 0.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-F_N PF10481.9 EFC41204.1 - 0.34 10.5 10.3 0.42 10.2 10.3 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain DUF3740 PF12548.8 EFC41204.1 - 0.38 11.2 5.7 0.042 14.3 1.6 1.5 2 0 0 2 2 2 0 Sulfatase protein Syntaxin-6_N PF09177.11 EFC41204.1 - 0.57 10.8 7.3 0.26 11.9 2.8 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FAM76 PF16046.5 EFC41204.1 - 0.81 9.0 8.5 0.91 8.8 8.5 1.0 1 0 0 1 1 1 0 FAM76 protein MAP70 PF07058.11 EFC41204.1 - 0.93 8.2 8.7 1.1 7.9 8.7 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 CTP_transf_1 PF01148.20 EFC41205.1 - 5.3e-39 134.6 14.7 5.3e-39 134.6 14.7 2.0 2 0 0 2 2 2 2 Cytidylyltransferase family S_4TM PF18159.1 EFC41205.1 - 1.2 8.4 8.2 0.44 9.8 0.1 2.8 3 0 0 3 3 3 0 SMODS-associating 4TM effector domain PfkB PF00294.24 EFC41207.1 - 2.4e-65 220.8 0.0 3.1e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase FliW PF02623.15 EFC41207.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 FliW protein DUF4116 PF13475.6 EFC41208.1 - 8.9e-11 41.3 8.6 6e-06 25.9 0.7 4.5 3 1 1 4 4 4 4 Domain of unknown function (DUF4116) SAMP PF05924.11 EFC41208.1 - 0.083 12.2 1.3 0.16 11.3 1.3 1.5 1 0 0 1 1 1 0 SAMP Motif START PF01852.19 EFC41209.1 - 2.1e-19 69.7 0.1 2.8e-19 69.4 0.1 1.2 1 0 0 1 1 1 1 START domain SWIB PF02201.18 EFC41210.1 - 2.4e-07 30.5 0.3 1.1e-06 28.4 0.0 2.3 2 0 0 2 2 2 1 SWIB/MDM2 domain SAPS PF04499.15 EFC41210.1 - 0.061 12.1 21.3 0.0049 15.7 12.6 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Prothymosin PF03247.14 EFC41210.1 - 1.7 9.1 29.1 0.6 10.6 18.0 2.7 2 0 0 2 2 2 0 Prothymosin/parathymosin family O-antigen_lig PF13425.6 EFC41210.1 - 1.9 7.2 4.9 4 6.1 4.9 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF5427 PF10310.9 EFC41210.1 - 2.1 7.2 32.8 0.15 11.0 5.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5427) SURF2 PF05477.11 EFC41210.1 - 2.5 7.7 22.0 1.9 8.1 11.0 2.3 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) DUF3474 PF11960.8 EFC41210.1 - 4.7 7.4 9.0 1.6 8.9 2.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) CDC45 PF02724.14 EFC41210.1 - 6.5 4.9 20.6 12 4.1 20.6 1.5 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 EFC41211.1 - 4.7e-14 52.5 6.5 0.00039 21.2 0.2 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat LisH_TPL PF17814.1 EFC41211.1 - 4.9e-08 32.5 0.1 1.4e-07 31.0 0.1 1.9 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 EFC41211.1 - 1.3e-07 31.8 0.0 0.57 10.5 0.0 4.3 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC41211.1 - 3.4e-07 29.3 0.1 0.00047 18.9 0.0 2.5 2 0 0 2 2 2 2 Nucleoporin Nup120/160 PX PF00787.24 EFC41212.1 - 1.3e-12 47.7 0.7 1.3e-12 47.7 0.7 2.2 2 0 0 2 2 2 1 PX domain CAP PF00188.26 EFC41215.1 - 3.9e-11 43.9 0.1 9.7e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family FAM220 PF15487.6 EFC41216.1 - 0.0083 15.8 3.3 0.0083 15.8 3.3 2.2 2 0 0 2 2 2 1 FAM220 family RXT2_N PF08595.11 EFC41216.1 - 0.077 13.0 8.0 0.47 10.5 1.1 2.7 3 0 0 3 3 3 0 RXT2-like, N-terminal FAM176 PF14851.6 EFC41216.1 - 0.48 10.1 6.6 0.45 10.2 1.4 2.3 2 0 0 2 2 2 0 FAM176 family CCDC74_C PF14917.6 EFC41216.1 - 0.72 10.4 7.7 0.094 13.2 2.4 2.0 2 0 0 2 2 2 0 Coiled coil protein 74, C terminal TFIIE-A_C PF11521.8 EFC41216.1 - 0.88 9.9 6.7 0.58 10.5 1.2 2.6 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Macoilin PF09726.9 EFC41216.1 - 2.2 6.7 18.4 0.012 14.2 0.5 2.1 1 1 1 2 2 2 0 Macoilin family ALS2CR11 PF15729.5 EFC41216.1 - 5.7 6.0 12.0 0.16 11.1 5.1 1.7 2 0 0 2 2 2 0 Amyotrophic lateral sclerosis 2 candidate 11 DUF2540 PF10802.8 EFC41217.1 - 0.014 15.4 0.8 1 9.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2540) SPC12 PF06645.13 EFC41217.1 - 0.29 11.3 1.1 20 5.4 0.6 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) SlyX PF04102.12 EFC41218.1 - 0.0026 18.3 2.4 0.046 14.3 0.5 2.2 1 1 1 2 2 2 1 SlyX Tup_N PF08581.10 EFC41218.1 - 0.0096 16.2 3.5 0.013 15.8 0.3 2.1 2 0 0 2 2 2 1 Tup N-terminal Snapin_Pallidin PF14712.6 EFC41218.1 - 0.013 15.9 2.4 0.025 15.0 2.3 1.6 1 1 0 1 1 1 0 Snapin/Pallidin DUF4446 PF14584.6 EFC41218.1 - 0.045 13.7 2.2 0.054 13.5 1.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) ATP-synt_E PF05680.12 EFC41218.1 - 0.051 13.9 0.6 0.11 12.8 0.1 1.9 1 1 0 2 2 2 0 ATP synthase E chain Sec2p PF06428.11 EFC41218.1 - 0.055 13.4 4.7 0.63 10.1 0.4 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Sulfatase_C PF14707.6 EFC41218.1 - 0.079 13.7 0.3 0.11 13.2 0.3 1.3 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF1664 PF07889.12 EFC41218.1 - 0.24 11.5 1.2 0.34 11.0 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) LRR_8 PF13855.6 EFC41219.1 - 5.8e-36 122.1 58.6 2.1e-10 40.2 1.9 8.9 4 2 4 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EFC41219.1 - 1.3e-30 104.9 65.9 2.6e-05 24.5 0.8 10.7 7 2 4 11 11 11 9 Leucine Rich repeats (2 copies) DSPc PF00782.20 EFC41219.1 - 3.5e-15 56.0 0.1 1.3e-14 54.1 0.0 2.0 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain LRR_1 PF00560.33 EFC41219.1 - 5.6e-12 44.5 50.4 3.8 8.4 0.1 15.6 15 3 0 15 15 15 4 Leucine Rich Repeat LRR_6 PF13516.6 EFC41219.1 - 3e-05 23.7 52.9 2.2 8.6 0.1 13.8 15 0 0 15 15 15 4 Leucine Rich repeat LRR_9 PF14580.6 EFC41219.1 - 0.00037 20.1 2.2 0.00037 20.1 2.2 5.5 1 1 1 5 5 5 3 Leucine-rich repeat LRR_5 PF13306.6 EFC41219.1 - 0.0046 16.9 13.0 0.05 13.6 1.1 3.2 2 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) PTPlike_phytase PF14566.6 EFC41219.1 - 0.012 15.7 0.1 0.094 12.8 0.0 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFC41219.1 - 0.056 13.0 0.0 0.094 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Hexapep PF00132.24 EFC41220.1 - 1.6e-11 43.5 21.1 8.5e-06 25.3 3.2 4.4 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 EFC41220.1 - 0.00071 18.6 4.0 0.0026 16.8 4.0 1.7 1 1 0 1 1 1 1 L-fucokinase Hexapep_2 PF14602.6 EFC41220.1 - 0.0071 16.1 16.1 0.05 13.4 4.4 3.8 4 1 1 5 5 5 2 Hexapeptide repeat of succinyl-transferase PPTA PF01239.22 EFC41221.1 - 5e-07 29.2 15.1 0.0072 16.0 0.2 5.1 5 0 0 5 5 5 3 Protein prenyltransferase alpha subunit repeat WD40 PF00400.32 EFC41222.1 - 1e-30 105.3 22.9 6e-07 30.1 0.2 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat Striatin PF08232.12 EFC41222.1 - 5.7e-24 85.5 5.2 2.5e-23 83.4 0.0 2.5 2 0 0 2 2 2 1 Striatin family ANAPC4_WD40 PF12894.7 EFC41222.1 - 4.9e-10 39.6 0.1 0.0083 16.4 0.0 5.0 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain SPATA24 PF15175.6 EFC41222.1 - 0.0051 16.7 0.1 0.0091 15.9 0.1 1.3 1 0 0 1 1 1 1 Spermatogenesis-associated protein 24 PQQ_2 PF13360.6 EFC41222.1 - 0.0054 16.3 0.0 0.025 14.1 0.0 1.7 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 EFC41222.1 - 0.043 13.8 0.0 2.4 8.2 0.0 2.7 2 0 0 2 2 2 0 PQQ enzyme repeat Frtz PF11768.8 EFC41222.1 - 0.046 12.0 0.0 0.18 10.1 0.0 1.8 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz GET2 PF08690.10 EFC41222.1 - 3.3 7.3 7.2 5.5 6.6 7.2 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 Amidase PF01425.21 EFC41224.1 - 2.2e-90 303.8 0.0 2.5e-89 300.3 0.0 1.9 1 1 0 1 1 1 1 Amidase RGS PF00615.19 EFC41225.1 - 5.3e-12 46.1 4.0 1.3e-11 44.8 4.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain CHASE4 PF05228.13 EFC41225.1 - 7.2e-11 42.4 0.0 2.5e-10 40.7 0.0 1.9 1 0 0 1 1 1 1 CHASE4 domain SBP_bac_3 PF00497.20 EFC41225.1 - 3.4e-09 36.5 0.0 9.3e-09 35.0 0.0 1.7 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 HAMP PF00672.25 EFC41225.1 - 9.8e-06 25.9 0.0 2.5e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 HAMP domain PAS_8 PF13188.7 EFC41225.1 - 0.0004 20.3 0.0 0.0013 18.7 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC41225.1 - 0.00061 19.8 0.0 0.0016 18.4 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EFC41225.1 - 0.05 13.9 0.0 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 PAS domain Sensor PF13796.6 EFC41225.1 - 0.79 9.8 3.3 2.2 8.3 0.3 2.3 2 0 0 2 2 2 0 Putative sensor YebO PF13974.6 EFC41225.1 - 4.2 7.5 7.0 2.9 8.0 1.0 2.7 2 0 0 2 2 2 0 YebO-like protein HemY_N PF07219.13 EFC41225.1 - 5.6 7.2 7.0 8.1 6.7 0.8 3.1 3 0 0 3 3 3 0 HemY protein N-terminus Ependymin PF00811.18 EFC41226.1 - 0.015 15.5 2.3 0.036 14.3 2.2 1.7 1 1 0 1 1 1 0 Ependymin DUF2183 PF09949.9 EFC41227.1 - 0.068 13.5 0.0 0.2 12.0 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) LRR_4 PF12799.7 EFC41227.1 - 0.26 11.7 18.7 2.3 8.7 0.5 6.2 3 2 2 5 5 5 0 Leucine Rich repeats (2 copies) 7TM_GPCR_Srx PF10328.9 EFC41229.1 - 0.0021 17.7 0.3 0.0021 17.7 0.3 1.9 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srx Chordopox_A13L PF05961.11 EFC41229.1 - 0.059 13.6 2.4 0.71 10.1 0.0 3.6 3 0 0 3 3 3 0 Chordopoxvirus A13L protein G6B PF15096.6 EFC41229.1 - 0.45 10.3 3.5 1.1 9.0 3.5 1.6 1 0 0 1 1 1 0 G6B family Mob1_phocein PF03637.17 EFC41230.1 - 1.2e-24 87.2 3.7 2e-24 86.5 3.7 1.3 1 0 0 1 1 1 1 Mob1/phocein family DUF755 PF05501.11 EFC41230.1 - 0.07 13.4 2.4 10 6.4 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF755) CAP_GLY PF01302.25 EFC41231.1 - 4.3e-25 87.5 0.4 7.4e-25 86.8 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 EFC41231.1 - 7.9e-25 87.1 0.1 1.4e-24 86.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 EFC41231.1 - 0.016 14.9 0.1 2.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin family PB1 PF00564.24 EFC41231.1 - 0.12 12.3 0.6 0.47 10.4 0.0 2.0 1 1 1 2 2 2 0 PB1 domain DUF4449 PF14613.6 EFC41232.1 - 0.002 18.2 1.0 0.002 18.2 1.0 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF4449) ArlS_N PF18719.1 EFC41232.1 - 0.025 14.8 0.9 0.11 12.7 0.9 2.2 1 0 0 1 1 1 0 ArlS sensor domain Metallophos PF00149.28 EFC41233.1 - 1e-27 98.0 0.0 1.4e-27 97.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFC41233.1 - 0.026 15.0 0.3 0.061 13.8 0.3 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Peptidase_C2 PF00648.21 EFC41234.1 - 1.6e-53 181.7 0.0 1.3e-47 162.3 0.0 3.3 2 1 0 2 2 2 2 Calpain family cysteine protease DUF2457 PF10446.9 EFC41234.1 - 3.2 6.8 8.0 9.3 5.3 8.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) LRR_6 PF13516.6 EFC41237.1 - 3.3e-84 269.9 17.5 9.4e-06 25.3 0.0 15.4 16 0 0 16 16 15 14 Leucine Rich repeat LRR_8 PF13855.6 EFC41237.1 - 2.8e-49 164.7 31.0 3.2e-10 39.6 3.3 6.6 3 3 3 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC41237.1 - 2.9e-46 154.7 41.8 1.4e-06 28.5 1.6 8.7 3 2 4 10 10 10 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41237.1 - 3.7e-36 118.1 3.7 1.5 9.7 0.0 15.0 15 0 0 15 15 15 6 Leucine Rich Repeat LRR_9 PF14580.6 EFC41237.1 - 2.9e-11 43.2 11.5 0.0013 18.3 1.9 4.3 1 1 4 5 5 5 4 Leucine-rich repeat ApoB100_C PF12491.8 EFC41237.1 - 2.3e-07 30.7 20.2 1.3 9.1 0.2 10.1 3 2 8 11 11 11 2 Apolipoprotein B100 C terminal Apo-VLDL-II PF05418.11 EFC41237.1 - 3.4e-06 27.5 1.3 15 6.2 0.1 6.0 3 2 5 8 8 7 0 Apovitellenin I (Apo-VLDL-II) Beta_helix PF13229.6 EFC41237.1 - 3.7e-05 23.6 29.7 0.0071 16.2 8.7 3.8 1 1 2 3 3 3 3 Right handed beta helix region DUF5490 PF17593.2 EFC41237.1 - 7.2e-05 22.7 11.4 22 5.1 0.0 8.9 6 2 6 12 12 10 0 Family of unknown function (DUF5490) DUF424 PF04242.13 EFC41237.1 - 0.0028 17.9 12.4 4.5 7.6 0.2 5.5 3 2 2 5 5 5 2 Protein of unknown function (DUF424) HydF_dimer PF18128.1 EFC41237.1 - 0.017 15.2 1.4 25 5.0 0.0 4.4 2 2 4 7 7 7 0 Hydrogen maturase F dimerization domain PHZA_PHZB PF03284.13 EFC41237.1 - 0.029 14.0 1.5 9.9 5.8 0.1 4.4 1 1 3 6 6 6 0 Phenazine biosynthesis protein A/B PulA_N1 PF17999.1 EFC41237.1 - 0.052 14.3 13.1 1.9 9.3 0.5 4.8 2 2 2 4 4 4 0 Pullulanase N1-terminal domain Glyco_transf_10 PF00852.19 EFC41237.1 - 0.21 11.3 2.9 5.1 6.8 0.0 3.8 2 2 3 5 5 5 0 Glycosyltransferase family 10 (fucosyltransferase) C-term Importin_rep_2 PF18786.1 EFC41237.1 - 2.3 8.1 6.3 3.3 7.6 0.3 4.3 4 2 2 6 6 6 0 Importin 13 repeat bZIP_C PF12498.8 EFC41237.1 - 4.7 8.2 15.3 14 6.7 2.1 4.4 2 1 3 5 5 5 0 Basic leucine-zipper C terminal RNF220 PF15926.5 EFC41237.1 - 4.9 6.7 9.9 31 4.1 1.1 4.5 1 1 2 4 4 4 0 E3 ubiquitin-protein ligase RNF220 DUF547 PF04784.14 EFC41238.1 - 3e-24 85.4 0.0 1.3e-23 83.3 0.0 2.1 1 0 0 1 1 1 1 Protein of unknown function, DUF547 RGS PF00615.19 EFC41238.1 - 0.011 16.0 4.3 0.011 16.0 4.3 4.1 3 1 0 3 3 3 0 Regulator of G protein signaling domain DUF4116 PF13475.6 EFC41239.1 - 5.4e-32 109.3 12.8 6.6e-11 41.8 0.1 4.2 1 1 4 5 5 5 5 Domain of unknown function (DUF4116) ubiquitin PF00240.23 EFC41239.1 - 1.6e-05 24.6 0.0 0.00011 21.8 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family Dus PF01207.17 EFC41241.1 - 4.1e-63 213.3 0.0 5.4e-63 212.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) mTERF PF02536.14 EFC41242.1 - 0.054 12.4 0.0 0.075 11.9 0.0 1.2 1 0 0 1 1 1 0 mTERF p450 PF00067.22 EFC41244.1 - 6.3e-75 252.7 1.4 7.6e-75 252.4 1.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 TarH PF02203.15 EFC41245.1 - 1.1 9.2 7.0 1.8 8.5 7.0 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue BTB PF00651.31 EFC41246.1 - 0.0012 19.1 0.2 0.0031 17.7 0.1 1.7 2 0 0 2 2 2 1 BTB/POZ domain PPP4R2 PF09184.11 EFC41246.1 - 7.8 6.0 15.7 14 5.2 15.7 1.5 1 1 0 1 1 1 0 PPP4R2 Aldedh PF00171.22 EFC41247.1 - 1.1e-90 304.4 0.0 1.6e-90 303.9 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFC41247.1 - 0.0058 15.7 0.0 0.0088 15.1 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) TIM PF00121.18 EFC41247.1 - 0.059 12.7 0.0 0.15 11.4 0.0 1.6 1 0 0 1 1 1 0 Triosephosphate isomerase BUD22 PF09073.10 EFC41248.1 - 0.049 13.0 12.1 0.048 13.0 12.1 1.1 1 0 0 1 1 1 0 BUD22 YL1 PF05764.13 EFC41248.1 - 0.25 11.4 13.7 0.32 11.1 13.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 EFC41248.1 - 4.4 6.5 14.3 7.7 5.7 14.3 1.4 1 0 0 1 1 1 0 NOA36 protein Abhydrolase_1 PF00561.20 EFC41249.1 - 7.2e-13 48.8 0.4 1.2e-12 48.1 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC41249.1 - 2.3e-08 33.6 0.0 3.4e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC41249.1 - 5.1e-06 27.3 0.0 8.2e-06 26.6 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EFC41249.1 - 0.0026 17.6 0.0 0.0046 16.8 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Ndr PF03096.14 EFC41249.1 - 0.024 13.4 0.0 0.038 12.7 0.0 1.3 1 0 0 1 1 1 0 Ndr family Palm_thioest PF02089.15 EFC41249.1 - 0.034 14.0 0.2 0.082 12.7 0.0 1.7 2 0 0 2 2 2 0 Palmitoyl protein thioesterase DUF915 PF06028.11 EFC41249.1 - 0.044 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) BAAT_C PF08840.11 EFC41249.1 - 0.047 13.6 0.0 0.1 12.5 0.0 1.6 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1057 PF06342.12 EFC41249.1 - 0.047 12.7 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) PGAP1 PF07819.13 EFC41249.1 - 0.061 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein DUF1749 PF08538.10 EFC41249.1 - 0.08 12.0 0.0 0.18 10.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) Lipase_3 PF01764.25 EFC41249.1 - 0.17 11.7 0.0 0.53 10.1 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) DUF202 PF02656.15 EFC41249.1 - 0.76 10.3 3.7 1.7 9.2 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) F-box-like PF12937.7 EFC41251.1 - 0.03 14.2 0.9 0.46 10.4 0.2 3.0 3 0 0 3 3 3 0 F-box-like RNA_pol_Rbc25 PF08292.12 EFC41251.1 - 2.4 8.4 4.7 1.5 9.0 2.6 1.8 1 1 1 2 2 2 0 RNA polymerase III subunit Rpc25 MORN PF02493.20 EFC41252.1 - 7.2e-47 154.6 44.4 5.2e-07 29.2 0.2 10.8 11 0 0 11 11 11 9 MORN repeat DUF3048_C PF17479.2 EFC41252.1 - 0.0033 17.8 12.7 1.4 9.3 1.0 4.4 2 2 2 4 4 4 4 Protein of unknown function (DUF3048) C-terminal domain Arrestin_C PF02752.22 EFC41253.1 - 6.6e-10 39.6 5.6 5.6e-06 26.9 0.7 2.8 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFC41253.1 - 5.9e-08 32.9 1.0 7.7e-05 22.8 0.1 2.9 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain EF-hand_7 PF13499.6 EFC41254.1 - 8.1e-06 26.2 2.0 0.0039 17.6 1.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC41254.1 - 0.00052 19.7 3.8 1.3 9.2 0.0 4.1 5 0 0 5 5 5 2 EF-hand domain EF-hand_1 PF00036.32 EFC41254.1 - 0.0055 16.2 0.5 0.73 9.5 0.0 3.8 4 0 0 4 4 4 1 EF hand Glyco_hydro_31 PF01055.26 EFC41255.1 - 1.6e-134 449.5 1.6 1.6e-134 449.5 1.6 1.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFC41255.1 - 1.8e-17 63.4 0.1 6.7e-17 61.6 0.1 2.1 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EFC41255.1 - 5.6e-07 29.7 1.5 2e-06 28.0 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) SCPU PF05229.15 EFC41255.1 - 0.091 13.2 0.0 4.4 7.7 0.0 2.5 2 0 0 2 2 2 0 Spore Coat Protein U domain LRR_6 PF13516.6 EFC41256.1 - 1e-15 56.3 19.8 6.8e-05 22.6 0.1 7.5 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EFC41256.1 - 1.8e-06 28.2 24.3 0.00038 20.8 4.5 5.1 2 1 3 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC41256.1 - 1.3e-05 24.9 22.6 0.0015 18.3 0.8 5.1 3 2 2 5 5 5 3 Leucine rich repeat DUF1456 PF07308.13 EFC41256.1 - 0.036 14.4 0.1 0.095 13.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) LRR_9 PF14580.6 EFC41256.1 - 0.067 12.7 1.5 0.86 9.1 0.1 2.3 1 1 1 2 2 2 0 Leucine-rich repeat LRR_1 PF00560.33 EFC41256.1 - 0.1 13.2 18.1 3.5 8.6 0.1 6.0 6 2 0 6 6 6 0 Leucine Rich Repeat Anoctamin PF04547.12 EFC41257.1 - 1.1e-18 67.4 17.4 2e-18 66.5 17.4 1.5 1 1 0 1 1 1 1 Calcium-activated chloride channel TMC PF07810.13 EFC41257.1 - 1.2e-09 38.7 0.2 1.2e-09 38.7 0.2 2.9 3 0 0 3 3 3 1 TMC domain Copine PF07002.16 EFC41260.1 - 4.1e-76 255.2 0.1 5.6e-76 254.8 0.1 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFC41260.1 - 1.5e-07 31.6 0.0 3.3e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain vWA-TerF-like PF10138.9 EFC41260.1 - 0.00074 19.7 0.0 0.0017 18.5 0.0 1.5 1 1 0 1 1 1 1 vWA found in TerF C terminus TFIIA PF03153.13 EFC41260.1 - 2.9 7.8 13.8 4.1 7.3 13.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 EFC41260.1 - 6.4 7.4 21.1 13 6.5 21.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2076 PF09849.9 EFC41260.1 - 8.2 6.4 13.5 15 5.5 13.5 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SOG2 PF10428.9 EFC41260.1 - 9 5.4 10.5 13 4.8 10.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Vps54 PF07928.12 EFC41261.1 - 1.7e-27 96.5 2.7 1.7e-27 96.5 2.7 3.7 4 0 0 4 4 4 1 Vps54-like protein Vps54_N PF10475.9 EFC41261.1 - 2e-08 33.9 6.2 7.4e-08 32.0 6.2 2.0 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Bac_DNA_binding PF00216.21 EFC41261.1 - 0.056 13.6 0.1 24 5.2 0.0 3.8 3 0 0 3 3 3 0 Bacterial DNA-binding protein COG5 PF10392.9 EFC41261.1 - 1.9 8.6 11.6 0.054 13.7 1.2 3.4 3 0 0 3 3 3 0 Golgi transport complex subunit 5 NHL PF01436.21 EFC41262.1 - 1.3e-21 75.5 0.1 1.4e-06 28.0 0.0 5.9 6 0 0 6 6 6 3 NHL repeat Arylesterase PF01731.20 EFC41262.1 - 0.1 12.8 0.1 12 6.2 0.0 3.2 3 0 0 3 3 3 0 Arylesterase DUF5128 PF17170.4 EFC41262.1 - 0.13 11.4 4.6 1.3 8.1 0.5 2.6 3 0 0 3 3 3 0 6-bladed beta-propeller F-box-like PF12937.7 EFC41263.1 - 0.65 9.9 2.8 0.48 10.4 0.2 2.2 2 0 0 2 2 2 0 F-box-like WD40 PF00400.32 EFC41265.1 - 2.9e-25 88.0 13.9 0.0097 16.8 0.0 9.9 10 0 0 10 10 10 8 WD domain, G-beta repeat BBS2_N PF14781.6 EFC41265.1 - 0.38 10.7 1.9 17 5.4 0.0 3.8 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, N-terminal TRAP_beta PF05753.14 EFC41266.1 - 3.2e-34 117.9 1.3 4.7e-34 117.3 1.3 1.1 1 0 0 1 1 1 1 Translocon-associated protein beta (TRAPB) DUF11 PF01345.18 EFC41266.1 - 0.0006 20.1 0.1 0.0006 20.1 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function DUF11 CARDB PF07705.11 EFC41266.1 - 0.0034 17.6 1.4 0.0057 16.9 0.3 2.0 1 1 1 2 2 2 1 CARDB HSP90 PF00183.18 EFC41267.1 - 1.4e-98 331.1 9.1 4.8e-98 329.3 2.4 2.4 2 1 1 3 3 3 2 Hsp90 protein HATPase_c_3 PF13589.6 EFC41267.1 - 9.5e-11 41.7 0.3 3.8e-10 39.7 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 EFC41267.1 - 1.6e-08 35.1 0.2 3e-08 34.1 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DHFR_2 PF06442.11 EFC41267.1 - 0.013 15.3 0.1 0.027 14.3 0.1 1.4 1 0 0 1 1 1 0 R67 dihydrofolate reductase Raco_middle PF17651.1 EFC41268.1 - 0.043 13.5 0.2 0.09 12.5 0.2 1.5 1 0 0 1 1 1 0 RACo middle region TFIIF_alpha PF05793.12 EFC41268.1 - 0.29 9.7 17.5 0.36 9.4 17.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NHL PF01436.21 EFC41269.1 - 1.1e-08 34.7 2.7 0.0048 16.9 0.0 2.9 2 0 0 2 2 2 2 NHL repeat SGL PF08450.12 EFC41269.1 - 0.088 12.4 0.0 10 5.6 0.0 2.2 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DSPc PF00782.20 EFC41270.1 - 6.7e-29 100.4 1.2 3.9e-28 97.9 0.1 2.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EFC41270.1 - 2e-18 65.9 41.7 6.4e-05 22.6 0.1 6.8 4 3 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC41270.1 - 3.4e-17 62.3 37.0 0.00013 22.2 7.8 6.4 4 2 2 6 6 6 6 Leucine Rich repeats (2 copies) Y_phosphatase PF00102.27 EFC41270.1 - 0.00024 20.7 0.0 0.0005 19.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_1 PF00560.33 EFC41270.1 - 0.0058 17.0 32.3 1 10.2 0.4 8.8 8 1 0 8 8 8 2 Leucine Rich Repeat Init_tRNA_PT PF04179.12 EFC41270.1 - 0.06 13.6 0.0 0.24 11.7 0.0 2.0 1 0 0 1 1 1 0 Rit1 DUSP-like domain LRR_6 PF13516.6 EFC41270.1 - 0.12 12.4 31.0 10 6.5 0.7 9.0 9 0 0 9 9 9 0 Leucine Rich repeat SPK PF04435.18 EFC41270.1 - 0.79 10.2 4.0 2.8 8.4 0.0 3.6 4 1 0 4 4 4 0 Domain of unknown function (DUF545) DUF1117 PF06547.12 EFC41270.1 - 7 7.2 6.1 11 6.6 5.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) DUF4116 PF13475.6 EFC41271.1 - 2e-56 187.5 6.1 5.5e-19 67.6 0.0 9.0 7 2 2 9 9 9 8 Domain of unknown function (DUF4116) DUF1667 PF07892.11 EFC41271.1 - 0.073 13.1 0.0 71 3.6 0.0 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1667) PHR PF08005.12 EFC41273.1 - 0.11 13.2 0.1 0.22 12.2 0.1 1.5 1 0 0 1 1 1 0 PHR domain DUF4233 PF14017.6 EFC41273.1 - 1.6 9.1 10.5 2.6 8.4 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4233) START PF01852.19 EFC41274.1 - 4.4e-07 29.5 0.0 0.00017 21.1 0.0 2.1 2 0 0 2 2 2 2 START domain Guanylate_cyc PF00211.20 EFC41275.1 - 1.7e-55 187.5 0.3 9.3e-54 181.8 0.1 2.5 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC41275.1 - 1.6e-13 50.8 0.1 5.2e-13 49.1 0.1 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC41275.1 - 6e-08 32.7 0.1 5.6e-07 29.6 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC41275.1 - 0.02 14.9 0.0 0.055 13.5 0.0 1.7 1 0 0 1 1 1 0 PAS domain NHL PF01436.21 EFC41276.1 - 4.5e-26 89.5 10.2 2.7e-05 24.0 0.3 6.1 6 0 0 6 6 6 5 NHL repeat DUF5128 PF17170.4 EFC41276.1 - 2.2e-09 36.9 13.1 9.4e-07 28.3 0.1 4.3 3 1 1 4 4 4 2 6-bladed beta-propeller SGL PF08450.12 EFC41276.1 - 7.7e-05 22.4 0.7 0.028 14.0 0.3 3.7 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC41276.1 - 0.0068 16.6 0.0 0.92 9.7 0.1 3.4 4 0 0 4 4 4 1 Arylesterase C2 PF00168.30 EFC41277.1 - 3.1e-24 85.2 0.0 7.6e-24 84.0 0.0 1.7 1 0 0 1 1 1 1 C2 domain Peptidase_C92 PF05708.12 EFC41277.1 - 7.5e-07 29.4 0.0 2.5e-05 24.5 0.0 2.3 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Mem_trans PF03547.18 EFC41278.1 - 7.4e-10 37.8 5.5 9e-10 37.5 5.5 1.1 1 0 0 1 1 1 1 Membrane transport protein Scramblase PF03803.15 EFC41279.1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.4 1 1 1 2 2 2 0 Scramblase Trypsin PF00089.26 EFC41280.1 - 1.1e-41 143.0 4.4 1.5e-41 142.6 4.4 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC41280.1 - 0.014 16.3 0.1 0.029 15.3 0.1 1.6 1 1 0 1 1 1 0 Trypsin-like peptidase domain Trypan_PARP PF05887.11 EFC41284.1 - 5.5e-06 26.4 96.1 0.012 15.6 35.7 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) FeS_assembly_P PF01883.19 EFC41285.1 - 6.8e-11 42.2 0.1 1.3e-10 41.3 0.0 1.5 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein NEMP PF10225.9 EFC41286.1 - 1.5 8.4 9.5 11 5.5 0.2 2.3 1 1 1 2 2 2 0 NEMP family Kelch_3 PF13415.6 EFC41287.1 - 0.074 13.4 8.0 2.7 8.4 0.1 4.5 3 1 1 4 4 4 0 Galactose oxidase, central domain VWA_2 PF13519.6 EFC41288.1 - 1.1e-05 26.0 0.0 3.1e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC41288.1 - 0.00024 21.4 0.1 0.0011 19.2 0.1 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC41288.1 - 0.018 15.0 0.0 0.069 13.1 0.0 2.0 2 1 0 2 2 2 0 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC41288.1 - 0.18 11.2 0.0 0.37 10.1 0.0 1.5 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein YjeF_N PF03853.15 EFC41289.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus Ras PF00071.22 EFC41291.1 - 8e-26 90.6 0.0 1.5e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41291.1 - 1.3e-15 57.7 0.2 3.1e-15 56.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41291.1 - 2.5e-09 36.8 0.0 7e-09 35.4 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 EFC41291.1 - 0.0011 18.7 0.0 0.0031 17.4 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC41291.1 - 0.0014 18.5 0.0 0.0037 17.1 0.0 1.7 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 EFC41291.1 - 0.0027 17.8 0.0 0.041 14.0 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC41291.1 - 0.048 13.1 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit ELO PF01151.18 EFC41292.1 - 0.0029 17.2 23.0 0.0034 16.9 8.6 3.4 2 2 0 2 2 2 1 GNS1/SUR4 family G-alpha PF00503.20 EFC41293.1 - 2.5e-13 49.9 12.5 4.2e-13 49.2 12.5 1.4 1 1 0 1 1 1 1 G-protein alpha subunit HTH_48 PF17906.1 EFC41293.1 - 0.07 13.3 0.2 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 HTH domain in Mos1 transposase ATP-grasp_2 PF08442.10 EFC41294.1 - 2.4e-62 210.1 0.2 3.7e-62 209.5 0.2 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 EFC41294.1 - 3.4e-25 88.6 3.0 7.9e-25 87.5 3.0 1.6 1 0 0 1 1 1 1 CoA-ligase Endonuc-MspI PF09208.10 EFC41294.1 - 0.012 15.0 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease MspI Peripla_BP_3 PF13377.6 EFC41294.1 - 0.054 13.8 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein-like domain FtsX PF02687.21 EFC41295.1 - 2.1 8.9 10.0 4.4 7.8 1.9 2.3 2 1 0 2 2 2 0 FtsX-like permease family Glyoxalase PF00903.25 EFC41296.1 - 4.4e-08 33.4 0.3 6.4e-07 29.6 0.3 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EFC41296.1 - 0.007 16.3 0.3 3.1 7.7 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 EFC41296.1 - 0.045 13.9 0.0 0.062 13.4 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain AAA PF00004.29 EFC41299.1 - 4.2e-08 33.7 0.0 1.1e-07 32.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFC41299.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AFG1_ATPase PF03969.16 EFC41299.1 - 0.14 11.0 0.0 0.25 10.2 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase LRR_4 PF12799.7 EFC41299.1 - 0.22 12.0 0.6 3.7 8.1 0.1 2.8 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) zf-RING_2 PF13639.6 EFC41300.1 - 9e-09 35.5 12.0 9e-09 35.5 12.0 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFC41300.1 - 9.3e-06 25.4 8.8 2.4e-05 24.1 8.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFC41300.1 - 1.1e-05 25.6 9.5 4.2e-05 23.7 9.5 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFC41300.1 - 2.6e-05 24.0 11.8 7.6e-05 22.5 11.8 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC41300.1 - 0.0003 20.8 7.9 0.0003 20.8 7.9 2.1 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC41300.1 - 0.00033 20.4 11.3 0.00081 19.2 11.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC41300.1 - 0.0018 18.2 11.2 0.0064 16.4 11.2 2.0 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFC41300.1 - 0.0057 16.5 10.8 0.021 14.7 10.8 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFC41300.1 - 0.043 13.9 2.7 0.15 12.2 2.7 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFC41300.1 - 0.076 12.8 7.6 0.17 11.7 7.6 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 EFC41300.1 - 0.12 12.5 5.8 0.048 13.8 3.0 1.8 2 0 0 2 2 1 0 Zinc-binding RING-finger FYVE PF01363.21 EFC41300.1 - 0.15 12.2 5.6 0.3 11.3 4.3 2.3 2 0 0 2 2 1 0 FYVE zinc finger zf-RING_11 PF17123.5 EFC41300.1 - 0.28 11.0 7.8 0.92 9.3 7.8 2.0 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 EFC41300.1 - 0.44 10.2 8.7 1 9.0 8.7 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 EFC41300.1 - 1.2 9.4 10.5 8.2 6.7 10.6 2.5 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING FMN_red PF03358.15 EFC41301.1 - 1.2e-11 44.6 0.0 1.6e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_5 PF12724.7 EFC41301.1 - 1.6e-06 28.4 0.0 0.001 19.3 0.0 2.3 1 1 1 2 2 2 2 Flavodoxin domain Flavodoxin_1 PF00258.25 EFC41301.1 - 0.00078 19.7 0.0 0.002 18.3 0.0 1.8 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_2 PF02525.17 EFC41301.1 - 0.0008 19.2 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold ubiquitin PF00240.23 EFC41302.1 - 7.4e-63 208.2 5.9 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC41302.1 - 2.9e-30 103.9 7.5 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC41302.1 - 5.5e-09 36.4 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC41302.1 - 1.3e-08 34.6 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC41302.1 - 1.4e-08 34.8 0.4 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC41302.1 - 5.8e-07 29.8 1.6 0.025 14.9 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC41302.1 - 1.2e-06 29.0 0.1 0.015 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC41302.1 - 9e-05 22.4 6.5 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain Coagulin PF02035.15 EFC41302.1 - 0.043 13.7 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC41302.1 - 0.05 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC41302.1 - 0.072 13.5 1.0 0.84 10.0 0.2 2.5 2 1 0 3 3 3 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC41302.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC41302.1 - 0.14 12.3 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC41302.1 - 0.22 11.7 1.5 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain Response_reg PF00072.24 EFC41303.1 - 1.7e-18 66.8 2.5 3.2e-17 62.7 0.1 3.3 3 0 0 3 3 3 1 Response regulator receiver domain HATPase_c PF02518.26 EFC41303.1 - 1.5e-16 60.9 4.6 6.3e-15 55.7 4.6 2.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC41303.1 - 0.039 14.0 0.0 7 6.8 0.0 3.0 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EFC41304.1 - 1.8e-18 66.8 0.3 1.1e-17 64.2 0.1 2.2 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 EFC41304.1 - 3.2e-07 30.8 0.2 6.7e-07 29.8 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IMD PF08397.11 EFC41304.1 - 0.037 13.4 0.0 0.075 12.4 0.0 1.5 1 0 0 1 1 1 0 IRSp53/MIM homology domain WIF PF02019.18 EFC41304.1 - 0.61 9.8 5.1 0.22 11.2 0.7 2.4 3 0 0 3 3 3 0 WIF domain Polyketide_cyc2 PF10604.9 EFC41305.1 - 1.9e-17 63.9 0.0 2.1e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EFC41305.1 - 0.00018 21.7 0.0 0.00024 21.3 0.0 1.2 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Bet_v_1 PF00407.19 EFC41305.1 - 0.0037 17.2 0.0 0.0045 16.9 0.0 1.1 1 0 0 1 1 1 1 Pathogenesis-related protein Bet v I family RGS PF00615.19 EFC41306.1 - 9.8e-16 58.1 2.8 9.8e-16 58.1 2.8 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Tox-ART-HYD1 PF15633.6 EFC41306.1 - 0.32 11.7 8.2 0.54 11.0 0.9 4.0 3 1 1 4 4 4 0 HYD1 signature containing ADP-ribosyltransferase DUF4361 PF14274.6 EFC41306.1 - 0.77 10.0 5.4 6.4 7.0 0.3 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4361) PIH1 PF08190.12 EFC41307.1 - 4.2e-26 91.4 2.6 4.2e-26 91.4 2.6 2.1 3 0 0 3 3 3 1 PIH1 N-terminal domain PIH1_CS PF18201.1 EFC41307.1 - 1e-22 80.4 2.2 1.3e-21 76.8 0.1 2.7 2 0 0 2 2 2 1 PIH1 CS-like domain Apc15p PF05841.11 EFC41307.1 - 1.5 9.7 8.7 0.26 12.1 4.6 1.9 2 0 0 2 2 2 0 Apc15p protein Sec7 PF01369.20 EFC41308.1 - 3.8e-37 127.7 1.4 9.5e-37 126.4 1.4 1.7 1 0 0 1 1 1 1 Sec7 domain Ras PF00071.22 EFC41308.1 - 7.8e-13 48.3 0.1 6.7e-07 29.0 0.0 3.7 3 0 0 3 3 3 3 Ras family AAA_14 PF13173.6 EFC41308.1 - 0.037 14.1 0.1 0.18 11.8 0.1 2.3 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 EFC41309.1 - 8.5e-30 100.2 34.1 3.6e-06 26.6 0.1 11.4 11 0 0 11 11 11 8 Leucine Rich repeat LRR_4 PF12799.7 EFC41309.1 - 1e-09 38.5 37.6 0.081 13.4 1.7 8.5 4 2 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41309.1 - 2e-09 36.7 11.5 4.7 8.2 0.0 8.6 7 2 0 7 7 7 3 Leucine Rich Repeat YdiH PF15930.5 EFC41309.1 - 0.016 15.4 0.6 1.9 8.7 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function LRR_8 PF13855.6 EFC41309.1 - 0.034 13.9 37.7 1.3 8.8 0.9 8.2 5 5 0 5 5 5 0 Leucine rich repeat Peptidase_C1 PF00112.23 EFC41310.1 - 2e-54 185.0 7.8 2e-54 185.0 7.8 3.6 3 1 2 5 5 5 1 Papain family cysteine protease EGF_2 PF07974.13 EFC41310.1 - 3.3e-25 88.1 144.3 1.3e-07 31.9 7.2 9.6 9 0 0 9 9 9 8 EGF-like domain EGF PF00008.27 EFC41310.1 - 0.0013 19.0 101.3 0.12 12.7 4.7 9.7 9 0 0 9 9 9 7 EGF-like domain Peptidase_C1_2 PF03051.15 EFC41310.1 - 0.036 12.8 2.1 0.38 9.5 0.1 2.1 2 0 0 2 2 2 0 Peptidase C1-like family DIOX_N PF14226.6 EFC41311.1 - 3.1e-11 44.0 0.0 6.1e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFC41311.1 - 0.0013 19.1 0.0 0.0031 18.0 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Prok-RING_4 PF14447.6 EFC41311.1 - 0.077 12.9 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 AI-2E_transport PF01594.16 EFC41312.1 - 0.18 10.9 2.7 1.4 8.0 0.1 2.0 2 0 0 2 2 2 0 AI-2E family transporter Chordopox_A13L PF05961.11 EFC41312.1 - 0.28 11.5 0.1 0.28 11.5 0.1 2.5 2 1 1 3 3 3 0 Chordopoxvirus A13L protein Neur_chan_memb PF02932.16 EFC41312.1 - 0.43 10.6 7.9 0.51 10.4 7.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region APG6_N PF17675.1 EFC41312.1 - 3.7 8.1 19.0 9.1 6.8 17.2 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region ISG65-75 PF11727.8 EFC41312.1 - 4.9 6.3 17.5 1 8.5 13.3 1.7 1 1 1 2 2 2 0 Invariant surface glycoprotein Spc7 PF08317.11 EFC41312.1 - 5.1 5.9 23.4 1 8.2 16.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein T4_Rnl2_C PF18043.1 EFC41314.1 - 0.072 13.2 0.9 0.6 10.3 0.1 2.5 2 0 0 2 2 2 0 T4 RNA ligase 2 C-terminal DUF4116 PF13475.6 EFC41315.1 - 4.5e-144 468.1 48.1 4.3e-17 61.6 0.2 10.9 3 3 10 14 14 14 14 Domain of unknown function (DUF4116) AAA_18 PF13238.6 EFC41315.1 - 1.5 9.4 3.8 40 4.8 0.1 3.2 2 1 1 3 3 3 0 AAA domain G-alpha PF00503.20 EFC41316.1 - 2.2e-39 135.6 15.8 2.8e-39 135.3 15.8 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC41316.1 - 0.0009 18.7 0.6 0.058 12.8 0.1 2.9 2 1 1 3 3 3 1 ADP-ribosylation factor family DUF4116 PF13475.6 EFC41317.1 - 2.5e-27 94.3 20.4 5.3e-09 35.7 0.1 8.5 4 2 4 9 9 9 7 Domain of unknown function (DUF4116) Prenyltransf PF01255.19 EFC41317.1 - 0.053 13.0 0.1 0.077 12.5 0.1 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase 60KD_IMP PF02096.20 EFC41318.1 - 1.2e-19 70.8 1.1 2.3e-19 69.9 1.1 1.4 1 0 0 1 1 1 1 60Kd inner membrane protein MelC1 PF06236.11 EFC41318.1 - 0.085 12.9 0.5 0.16 12.1 0.5 1.5 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 DUF4282 PF14110.6 EFC41318.1 - 1.2 9.9 4.5 24 5.8 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4282) Carbpep_Y_N PF05388.11 EFC41318.1 - 2.3 8.7 5.6 0.23 12.0 0.3 2.0 3 0 0 3 3 3 0 Carboxypeptidase Y pro-peptide Sel1 PF08238.12 EFC41319.1 - 8.1e-51 169.3 16.6 1.1e-08 35.4 0.1 7.8 8 0 0 8 8 8 6 Sel1 repeat TPR_1 PF00515.28 EFC41319.1 - 4.6e-05 23.1 1.6 0.00029 20.5 0.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC41319.1 - 0.0049 16.9 1.7 0.019 15.1 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41319.1 - 0.015 15.5 3.9 0.032 14.4 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4116 PF13475.6 EFC41320.1 - 1.4e-20 72.7 0.4 3.4e-12 45.9 0.1 3.7 3 1 1 4 4 4 3 Domain of unknown function (DUF4116) Lipase_GDSL_2 PF13472.6 EFC41322.1 - 5.2e-09 36.7 0.0 8.9e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFC41322.1 - 2.1e-07 31.1 0.0 4.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase TnpB_IS66 PF05717.13 EFC41322.1 - 0.078 12.9 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 IS66 Orf2 like protein DnaJ PF00226.31 EFC41323.1 - 4.6e-25 87.5 4.4 7.4e-25 86.9 4.4 1.3 1 0 0 1 1 1 1 DnaJ domain Corona_S2 PF01601.16 EFC41323.1 - 0.001 17.7 0.6 0.0012 17.4 0.6 1.2 1 0 0 1 1 1 1 Coronavirus S2 glycoprotein TMEM52 PF14979.6 EFC41323.1 - 0.0012 18.7 8.4 0.064 13.2 5.9 2.2 2 0 0 2 2 2 1 Transmembrane 52 LMBR1 PF04791.16 EFC41323.1 - 0.004 16.1 1.1 0.0042 16.1 0.3 1.3 1 1 0 1 1 1 1 LMBR1-like membrane protein DUF975 PF06161.11 EFC41323.1 - 0.0057 16.5 1.0 0.0095 15.7 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF975) FAM163 PF15069.6 EFC41323.1 - 0.0078 16.7 5.6 0.0078 16.7 5.6 2.1 2 0 0 2 2 2 1 FAM163 family DUF2207 PF09972.9 EFC41323.1 - 0.0078 15.0 0.0 0.0092 14.8 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 EFC41323.1 - 0.0098 16.7 6.0 0.015 16.2 0.7 2.6 2 1 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Las1 PF04031.13 EFC41323.1 - 0.028 14.5 0.1 0.07 13.2 0.1 1.7 1 1 0 1 1 1 0 Las1-like Phage_Gp23 PF10669.9 EFC41323.1 - 0.029 14.7 0.9 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) TssO PF17561.2 EFC41323.1 - 0.031 14.4 5.8 0.042 13.9 1.8 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO DUF3810 PF12725.7 EFC41323.1 - 0.036 13.4 5.1 0.019 14.3 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) TrmK PF04816.12 EFC41323.1 - 0.039 13.5 1.4 0.055 13.0 1.4 1.1 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase DUF87 PF01935.17 EFC41323.1 - 0.082 13.0 0.4 0.11 12.5 0.4 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain Cadherin_C_2 PF16492.5 EFC41323.1 - 0.19 12.5 6.5 5.3 7.9 0.5 2.5 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Shisa PF13908.6 EFC41323.1 - 0.21 11.8 14.7 0.093 13.0 10.8 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 EFC41323.1 - 0.29 12.1 5.4 0.55 11.2 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Innexin PF00876.18 EFC41323.1 - 0.55 9.5 7.4 1.3 8.2 0.6 2.3 1 1 1 2 2 2 0 Innexin Prominin PF05478.11 EFC41323.1 - 0.67 7.8 18.1 0.012 13.6 9.3 1.9 1 1 1 2 2 2 0 Prominin ETRAMP PF09716.10 EFC41323.1 - 0.92 9.6 10.2 6.5 6.9 3.3 2.9 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) GRP PF07172.11 EFC41323.1 - 0.99 10.1 3.2 15 6.3 0.0 2.8 2 2 1 3 3 3 0 Glycine rich protein family OspD PF03207.13 EFC41323.1 - 1.3 8.3 7.6 0.18 11.1 0.3 2.2 2 1 0 2 2 2 0 Borrelia outer surface protein D (OspD) SCIMP PF15050.6 EFC41323.1 - 4.8 7.6 6.1 0.5 10.8 0.6 2.0 2 1 0 2 2 2 0 SCIMP protein TMIE PF16038.5 EFC41323.1 - 6.1 6.8 9.9 0.79 9.6 2.2 2.5 2 0 0 2 2 2 0 TMIE protein TMEM132D_C PF15706.5 EFC41323.1 - 6.6 6.6 5.9 2 8.3 1.7 2.3 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Comm PF15957.5 EFC41323.1 - 7.5 6.9 12.1 0.36 11.2 2.5 2.5 2 1 0 2 2 2 0 Commissureless Mucin PF01456.17 EFC41323.1 - 8.8 6.3 6.9 8.9 6.3 4.1 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein DnaJ PF00226.31 EFC41325.1 - 7.1e-22 77.3 1.6 1.5e-21 76.3 1.6 1.5 1 0 0 1 1 1 1 DnaJ domain DUF3007 PF11460.8 EFC41325.1 - 0.16 12.2 0.4 1.4 9.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) 7tm_1 PF00001.21 EFC41325.1 - 0.21 10.9 0.0 0.22 10.8 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) ADP_ribosyl_GH PF03747.14 EFC41327.1 - 7.2e-50 170.4 0.0 9.1e-50 170.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase DUF4116 PF13475.6 EFC41328.1 - 8.9e-42 140.6 23.6 4.7e-10 39.0 0.0 9.3 5 2 6 11 11 11 10 Domain of unknown function (DUF4116) FucT_N PF18025.1 EFC41328.1 - 0.021 15.2 1.5 0.069 13.6 0.4 2.5 2 0 0 2 2 2 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain HSCB_C PF07743.13 EFC41328.1 - 2.8 8.5 7.8 0.19 12.2 1.1 2.6 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Fibrinogen_C PF00147.18 EFC41329.1 - 4.2e-06 26.7 0.0 7.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Cob_adeno_trans PF01923.18 EFC41329.1 - 0.012 15.7 0.2 0.02 15.0 0.2 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Tektin PF03148.14 EFC41329.1 - 0.16 10.7 4.0 0.14 10.9 1.1 1.9 2 0 0 2 2 2 0 Tektin family Orai-1 PF07856.12 EFC41329.1 - 9.1 5.9 7.8 5.3 6.7 5.4 1.7 1 1 1 2 2 2 0 Mediator of CRAC channel activity HSP70 PF00012.20 EFC41330.1 - 5e-47 160.4 0.2 2e-46 158.4 0.0 1.8 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EFC41330.1 - 1.1e-08 34.2 0.0 1.8e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein Phage_integrase PF00589.22 EFC41330.1 - 0.11 12.3 0.2 1.1 9.0 0.1 2.3 2 0 0 2 2 2 0 Phage integrase family RCC1_2 PF13540.6 EFC41331.1 - 0.00083 19.1 6.0 0.017 14.9 0.8 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat TPR_2 PF07719.17 EFC41333.1 - 1.2e-30 103.1 20.0 0.0046 17.0 0.1 9.3 8 1 1 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41333.1 - 4.8e-28 95.0 28.0 0.00012 22.0 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41333.1 - 1.2e-27 94.5 23.4 0.00034 20.3 1.9 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41333.1 - 8.2e-24 83.0 8.1 2.2e-06 27.2 0.5 6.8 6 1 1 7 7 7 4 TPR repeat TPR_19 PF14559.6 EFC41333.1 - 1.1e-19 70.7 2.1 0.00013 22.4 0.0 5.6 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC41333.1 - 5e-19 67.2 13.4 0.0024 18.1 0.0 7.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41333.1 - 1.4e-18 66.9 13.7 3.1e-05 24.2 0.1 7.1 3 3 3 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFC41333.1 - 4.2e-16 58.4 6.0 0.56 11.0 0.5 8.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC41333.1 - 1e-15 58.1 0.0 0.0048 17.5 0.0 4.6 4 2 1 5 5 5 3 Tetratricopeptide repeat RCC1_2 PF13540.6 EFC41333.1 - 5.9e-14 51.4 0.0 1.3e-05 24.9 0.0 4.3 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC41333.1 - 2.8e-13 50.2 0.1 0.38 11.4 0.0 5.6 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat TPR_14 PF13428.6 EFC41333.1 - 3.6e-13 49.1 2.1 0.12 13.2 0.0 7.8 5 2 4 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41333.1 - 2.7e-11 42.7 12.5 0.042 13.9 0.6 8.1 7 1 1 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC41333.1 - 5.9e-08 32.8 11.0 0.17 12.1 1.2 4.7 3 2 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EFC41333.1 - 1.6e-06 27.3 10.6 0.0037 16.2 0.1 4.5 1 1 3 5 5 5 2 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 EFC41333.1 - 4.6e-05 23.5 0.1 0.28 11.3 0.0 3.7 2 1 1 3 3 3 2 Tetratricopeptide repeat PPR PF01535.20 EFC41333.1 - 0.0031 17.6 2.6 28 5.2 0.0 5.5 4 1 1 5 5 5 0 PPR repeat TPR_10 PF13374.6 EFC41333.1 - 0.0064 16.3 10.5 23 5.0 0.0 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_15 PF13429.6 EFC41333.1 - 0.016 14.4 2.8 0.41 9.8 0.5 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4505 PF14956.6 EFC41333.1 - 0.056 13.2 0.4 0.24 11.1 0.6 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4505) TPR_20 PF14561.6 EFC41333.1 - 0.069 13.5 0.2 5.4 7.4 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFC41333.1 - 0.13 12.3 11.0 0.23 11.5 0.1 3.9 2 2 1 3 3 3 0 Putative TPR-like repeat DUF1955 PF09205.10 EFC41333.1 - 0.18 11.5 1.3 1.7 8.4 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1955) MIT PF04212.18 EFC41333.1 - 0.19 11.8 7.5 0.58 10.3 0.1 4.1 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 EFC41333.1 - 0.86 9.3 6.8 7.2 6.3 0.1 3.9 2 1 2 4 4 4 0 26S proteasome subunit RPN7 DUF1479 PF07350.12 EFC41334.1 - 1.5e-07 30.6 0.0 0.0021 16.9 0.0 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 EFC41334.1 - 5.3e-07 30.1 0.1 0.044 14.0 0.0 3.2 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) DUF5070 PF16802.5 EFC41334.1 - 0.00041 20.3 0.1 0.00076 19.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5070) VPS9 PF02204.18 EFC41335.1 - 5.8e-19 68.2 1.0 3.2e-17 62.6 0.1 3.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF5082 PF16888.5 EFC41335.1 - 1.1 9.5 7.6 0.15 12.4 1.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF1664 PF07889.12 EFC41335.1 - 1.7 8.7 6.0 3.8 7.6 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) LRR_2 PF07723.13 EFC41336.1 - 0.0022 18.6 2.0 5.5 7.8 0.1 5.7 4 1 1 5 5 5 1 Leucine Rich Repeat F-box_4 PF15966.5 EFC41336.1 - 0.044 13.7 0.2 0.19 11.6 0.1 2.0 1 1 0 1 1 1 0 F-box F-box PF00646.33 EFC41336.1 - 0.25 11.3 2.3 0.53 10.2 0.4 2.6 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EFC41336.1 - 1.6 8.7 3.9 2.1 8.3 0.1 2.8 3 0 0 3 3 3 0 F-box-like SHE3 PF17078.5 EFC41337.1 - 0.00085 19.1 3.8 0.0019 18.0 3.8 1.5 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Leu_zip PF15294.6 EFC41337.1 - 0.0015 18.1 0.1 0.0027 17.3 0.1 1.3 1 0 0 1 1 1 1 Leucine zipper PI3K_P85_iSH2 PF16454.5 EFC41337.1 - 0.011 15.4 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FH2 PF02181.23 EFC41337.1 - 0.028 13.5 0.1 0.051 12.7 0.1 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain GOLGA2L5 PF15070.6 EFC41337.1 - 0.034 12.8 0.6 0.05 12.3 0.6 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 UPF0242 PF06785.11 EFC41337.1 - 0.04 14.0 0.6 0.067 13.3 0.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 EFC41337.1 - 0.077 13.1 4.3 0.38 10.9 1.1 2.4 1 1 1 2 2 2 0 bZIP transcription factor GAS PF13851.6 EFC41337.1 - 0.098 12.0 5.8 0.17 11.2 5.8 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ATPgrasp_Ter PF15632.6 EFC41337.1 - 0.12 12.1 0.1 0.43 10.3 0.1 1.9 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon TMF_DNA_bd PF12329.8 EFC41337.1 - 0.47 10.5 4.3 1.1 9.3 4.3 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding TSC22 PF01166.18 EFC41337.1 - 0.71 10.2 5.3 3.5 8.0 1.1 2.6 1 1 1 2 2 2 0 TSC-22/dip/bun family IFP_35_N PF07334.13 EFC41337.1 - 0.85 9.7 8.1 0.43 10.7 1.9 3.3 2 2 2 4 4 4 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus GIT_CC PF16559.5 EFC41337.1 - 0.87 9.5 5.1 3.3 7.6 5.1 2.0 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 EFC41337.1 - 2.2 8.8 8.2 4.7 7.7 8.2 1.5 1 0 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 EFC41337.1 - 5.5 7.2 7.5 1.8 8.7 2.8 2.3 1 1 1 2 2 2 0 Basic region leucine zipper RIH_assoc PF08454.11 EFC41338.1 - 0.026 14.4 0.3 2.6 7.9 0.0 2.9 2 0 0 2 2 2 0 RyR and IP3R Homology associated p450 PF00067.22 EFC41339.1 - 9.4e-53 179.6 4.3 1.1e-52 179.4 4.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 Arm PF00514.23 EFC41340.1 - 1.3e-12 47.3 0.0 1.5e-08 34.4 0.0 3.3 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 EFC41340.1 - 3.2e-05 24.1 2.1 0.0097 16.1 0.1 3.1 2 1 1 3 3 3 2 Rapamycin-insensitive companion of mTOR, domain 5 DUF1955 PF09205.10 EFC41340.1 - 0.5 10.1 6.5 0.4 10.4 0.6 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF1955) FA_desaturase PF00487.24 EFC41341.1 - 6.9e-27 94.9 10.6 1.2e-26 94.1 10.6 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFC41341.1 - 3.7e-16 59.0 0.1 6.8e-16 58.2 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4013 PF13197.6 EFC41341.1 - 0.017 15.0 4.4 0.052 13.4 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4013) FA_hydroxylase PF04116.13 EFC41342.1 - 3.1e-20 72.9 15.2 3.1e-20 72.9 15.2 2.2 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily DUF4190 PF13828.6 EFC41343.1 - 0.8 9.5 5.4 0.57 10.0 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4190) MARVEL PF01284.23 EFC41343.1 - 1.4 9.0 8.8 4.2 7.4 3.2 2.2 1 1 1 2 2 2 0 Membrane-associating domain EGF_2 PF07974.13 EFC41344.1 - 2.6e-135 440.4 1021.3 7.2e-06 26.3 7.5 64.9 63 1 1 64 64 64 62 EGF-like domain RTC4 PF14474.6 EFC41344.1 - 0.12 12.5 0.1 8.6 6.5 0.0 4.0 5 0 0 5 5 5 0 RTC4-like domain VasI PF11319.8 EFC41347.1 - 0.12 12.1 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 Type VI secretion system VasI, EvfG, VC_A0118 Dynactin_p22 PF07426.11 EFC41348.1 - 0.0013 18.6 0.9 0.0013 18.6 0.9 2.5 2 0 0 2 2 2 1 Dynactin subunit p22 Glycophorin_A PF01102.18 EFC41348.1 - 0.02 15.1 0.1 0.02 15.1 0.1 4.7 5 1 1 6 6 6 0 Glycophorin A CpXC PF14353.6 EFC41348.1 - 0.079 13.0 0.1 0.29 11.2 0.1 1.9 1 0 0 1 1 1 0 CpXC protein DNA_III_psi PF03603.13 EFC41349.1 - 3.9 7.7 5.5 1.2 9.4 1.6 2.2 2 0 0 2 2 2 0 DNA polymerase III psi subunit Dus PF01207.17 EFC41350.1 - 2.3e-67 227.3 0.0 2.9e-67 227.0 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 EFC41350.1 - 0.059 12.8 0.0 0.091 12.2 0.0 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein Peptidase_M1 PF01433.20 EFC41351.1 - 4.2e-77 258.6 3.0 4.2e-77 258.6 3.0 1.7 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFC41351.1 - 9.2e-70 235.7 0.9 9.2e-70 235.7 0.9 1.6 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFC41351.1 - 2.4e-38 132.2 0.2 1.1e-36 126.8 0.0 2.4 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain LRR_12 PF18837.1 EFC41351.1 - 0.15 11.8 0.1 0.39 10.4 0.1 1.7 1 0 0 1 1 1 0 Leucine-rich repeat MAPEG PF01124.18 EFC41353.1 - 1.9e-19 69.8 3.6 2.3e-19 69.6 3.6 1.1 1 0 0 1 1 1 1 MAPEG family Kelch_5 PF13854.6 EFC41353.1 - 0.13 12.3 0.9 0.23 11.5 0.0 1.8 2 0 0 2 2 2 0 Kelch motif Peripla_BP_6 PF13458.6 EFC41354.1 - 1.9e-55 188.9 0.0 8.7e-42 144.0 0.1 3.6 3 1 0 3 3 3 3 Periplasmic binding protein Guanylate_cyc PF00211.20 EFC41354.1 - 1.5e-26 93.2 0.0 2.9e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ANF_receptor PF01094.28 EFC41354.1 - 9.3e-18 64.4 2.6 9.9e-11 41.3 0.0 3.3 3 0 0 3 3 3 3 Receptor family ligand binding region PhetRS_B1 PF18262.1 EFC41355.1 - 7e-31 106.3 0.4 1.4e-30 105.3 0.1 1.7 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 EFC41355.1 - 1.8e-09 37.5 0.0 2.7e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 EFC41355.1 - 0.087 13.1 0.1 0.27 11.6 0.0 1.9 2 1 0 2 2 2 0 tRNA synthetase B5 domain IBN_N PF03810.19 EFC41357.1 - 3.4e-17 62.1 9.6 1.2e-15 57.2 0.8 4.5 4 0 0 4 4 4 1 Importin-beta N-terminal domain UNC45-central PF11701.8 EFC41357.1 - 0.0091 16.0 8.9 0.27 11.2 1.2 3.5 4 0 0 4 4 4 2 Myosin-binding striated muscle assembly central DUF2110 PF09883.9 EFC41357.1 - 0.037 13.6 0.0 0.075 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) Xpo1 PF08389.12 EFC41357.1 - 0.055 13.5 0.2 0.055 13.5 0.2 5.1 3 2 2 6 6 6 0 Exportin 1-like protein HEAT_EZ PF13513.6 EFC41357.1 - 0.091 13.3 0.0 2.2 8.9 0.0 3.1 3 0 0 3 3 3 0 HEAT-like repeat HrpB1_HrpK PF09613.10 EFC41357.1 - 0.13 11.9 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) RICTOR_V PF14668.6 EFC41357.1 - 0.22 11.8 1.5 0.87 9.9 0.0 2.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 RIX1 PF08167.12 EFC41357.1 - 0.57 9.9 5.7 0.68 9.7 2.3 2.8 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis PCI PF01399.27 EFC41358.1 - 5e-18 65.5 1.2 2.7e-16 60.0 0.1 2.6 2 0 0 2 2 2 2 PCI domain CNOT1_CAF1_bind PF16415.5 EFC41358.1 - 0.0089 15.4 0.2 8.6 5.7 0.0 3.2 3 1 0 3 3 3 2 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Sar8_2 PF03058.14 EFC41359.1 - 0.015 15.9 0.3 0.02 15.4 0.3 1.4 1 1 0 1 1 1 0 Sar8.2 family Ras PF00071.22 EFC41360.1 - 1.6e-26 92.9 0.0 2.9e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41360.1 - 7e-17 61.8 0.2 1.6e-16 60.6 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41360.1 - 2e-08 33.9 0.0 4.6e-08 32.7 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 EFC41360.1 - 0.0012 18.6 0.0 0.0031 17.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC41360.1 - 0.0015 18.4 0.0 0.0037 17.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 EFC41360.1 - 0.0028 17.7 0.0 0.044 13.9 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC41360.1 - 0.071 12.5 0.0 0.21 11.0 0.0 1.8 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DUF3127 PF11325.8 EFC41360.1 - 0.11 12.7 0.1 0.36 11.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3127) 2OG-FeII_Oxy_3 PF13640.6 EFC41361.1 - 4.6e-06 27.4 0.0 6.9e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC41361.1 - 1.8e-05 25.1 0.0 3.2e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Methyltr_RsmB-F PF01189.17 EFC41364.1 - 1.5e-37 129.2 0.0 2.8e-36 125.1 0.0 2.3 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 EFC41364.1 - 0.0025 17.9 0.0 0.0064 16.6 0.0 1.7 1 0 0 1 1 1 1 FtsJ-like methyltransferase Sod_Ni PF09055.11 EFC41364.1 - 0.56 10.8 3.4 0.95 10.0 0.5 2.4 2 0 0 2 2 2 0 Nickel-containing superoxide dismutase D123 PF07065.14 EFC41366.1 - 1e-21 77.4 4.2 8.9e-20 71.0 0.8 3.2 2 1 0 2 2 2 2 D123 R2K_2 PF18299.1 EFC41366.1 - 0.0001 22.2 0.0 0.00041 20.2 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 EFC41366.1 - 0.00011 22.3 0.0 0.0002 21.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 DUF4379 PF14311.6 EFC41366.1 - 0.0097 16.2 1.0 0.53 10.7 0.1 3.1 2 0 0 2 2 2 1 Probable Zinc-ribbon domain DUF4513 PF14983.6 EFC41366.1 - 0.098 12.7 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4513) Rsbr_N PF08678.10 EFC41366.1 - 0.27 11.3 12.2 0.24 11.5 0.1 3.8 4 0 0 4 4 4 0 Rsbr N terminal Kelch_6 PF13964.6 EFC41367.1 - 0.26 11.6 10.4 1.2 9.5 0.3 3.7 4 0 0 4 4 4 0 Kelch motif Pkinase PF00069.25 EFC41369.1 - 4e-34 118.2 1.8 8.3e-22 77.8 0.1 3.0 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41369.1 - 2.7e-25 89.1 0.0 8.5e-17 61.3 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Dynamin_N PF00350.23 EFC41369.1 - 4.5e-11 43.1 0.2 1.7e-10 41.2 0.4 1.9 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFC41369.1 - 1.1e-09 38.4 0.1 3.6e-09 36.7 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Kdo PF06293.14 EFC41369.1 - 2.5e-06 27.0 0.1 0.00061 19.2 0.1 2.6 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC41369.1 - 0.00035 19.5 0.0 0.00063 18.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC41369.1 - 0.0048 16.9 0.0 0.02 14.8 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family RsgA_GTPase PF03193.16 EFC41369.1 - 0.023 14.6 0.0 0.061 13.2 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Roc PF08477.13 EFC41369.1 - 0.16 12.2 2.0 2.8 8.2 0.1 2.9 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFC41369.1 - 0.64 9.3 7.4 0.072 12.4 0.8 2.7 4 0 0 4 4 4 0 AIG1 family DUF4116 PF13475.6 EFC41370.1 - 3.4e-51 170.8 38.7 7.3e-13 48.0 0.1 10.5 5 4 4 9 9 9 8 Domain of unknown function (DUF4116) SAM_3 PF18016.1 EFC41371.1 - 0.00069 19.4 0.0 0.00097 18.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC41371.1 - 0.0077 16.7 0.4 0.011 16.1 0.4 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RecX PF02631.16 EFC41371.1 - 0.69 10.4 3.9 0.61 10.6 2.6 1.5 2 0 0 2 2 2 0 RecX family DUF3292 PF11696.8 EFC41372.1 - 0.064 11.6 0.0 0.085 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF1295 PF06966.12 EFC41373.1 - 1.6e-22 80.2 13.2 2.4e-21 76.3 13.2 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) SSP160 PF06933.11 EFC41373.1 - 0.048 11.9 0.6 0.064 11.4 0.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 ICMT PF04140.14 EFC41373.1 - 0.058 13.8 0.2 0.058 13.8 0.2 2.3 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 EFC41373.1 - 0.12 12.3 12.0 0.023 14.7 7.0 2.2 2 0 0 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase TPR_1 PF00515.28 EFC41374.1 - 3.8e-05 23.3 0.1 0.001 18.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC41374.1 - 0.00045 20.1 0.0 0.16 12.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC41374.1 - 0.026 14.9 1.0 5.2 7.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41374.1 - 0.12 12.7 0.1 0.12 12.7 0.1 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41374.1 - 0.32 11.1 1.6 1.4 9.2 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Epimerase PF01370.21 EFC41374.1 - 1.3 8.5 3.5 0.64 9.4 0.7 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family G_glu_transpept PF01019.21 EFC41376.1 - 2.3e-61 208.2 0.0 2.9e-61 207.8 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF3477 PF11963.8 EFC41376.1 - 0.13 11.5 0.0 0.18 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) PLDc_2 PF13091.6 EFC41378.1 - 2.1e-25 89.1 0.1 4.6e-15 55.7 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain ABC1 PF03109.16 EFC41379.1 - 7e-22 77.8 0.0 6.6e-20 71.5 0.0 2.6 2 0 0 2 2 2 1 ABC1 family Pkinase_Tyr PF07714.17 EFC41379.1 - 0.0096 15.2 0.3 0.029 13.7 0.3 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC41379.1 - 0.012 15.5 0.1 0.022 14.7 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFC41379.1 - 0.032 13.6 0.1 0.34 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain DUF4116 PF13475.6 EFC41380.1 - 4.2e-104 340.2 2.4 1.1e-17 63.5 0.0 9.1 4 1 6 11 11 11 11 Domain of unknown function (DUF4116) GLTP PF08718.11 EFC41380.1 - 0.017 15.4 1.4 1.3 9.3 0.1 3.4 1 1 1 2 2 2 0 Glycolipid transfer protein (GLTP) DUF4185 PF13810.6 EFC41380.1 - 0.05 12.8 0.0 0.099 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4185) Syntaxin-6_N PF09177.11 EFC41380.1 - 0.059 13.9 4.4 0.19 12.3 0.2 3.2 2 1 0 3 3 3 0 Syntaxin 6, N-terminal DUF1667 PF07892.11 EFC41380.1 - 0.085 12.9 0.1 17 5.6 0.0 3.9 3 2 1 4 4 4 0 Protein of unknown function (DUF1667) DUF1611_N PF17396.2 EFC41381.1 - 0.064 13.5 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_N) Rossmann-like domain PNK3P PF08645.11 EFC41382.1 - 1.3e-46 158.2 0.1 2.2e-46 157.5 0.1 1.4 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 EFC41382.1 - 2.6e-16 60.1 0.0 5.8e-07 29.8 0.0 3.2 2 1 1 3 3 3 2 AAA domain Zeta_toxin PF06414.12 EFC41382.1 - 0.0099 15.2 0.0 2.2 7.5 0.0 2.5 2 1 1 3 3 3 2 Zeta toxin KTI12 PF08433.10 EFC41382.1 - 0.058 12.8 1.0 0.22 10.9 0.0 2.2 2 1 1 3 3 3 0 Chromatin associated protein KTI12 PK_C PF02887.16 EFC41382.1 - 0.19 12.0 0.0 1.7 8.9 0.0 2.3 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain PBP1_TM PF14812.6 EFC41382.1 - 1.4 9.4 6.2 0.6 10.5 3.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ank_4 PF13637.6 EFC41383.1 - 7.6e-05 23.2 0.2 4.3 8.0 0.0 5.5 6 0 0 6 6 6 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC41383.1 - 0.00028 21.4 7.2 0.34 11.5 0.1 5.0 5 1 1 6 6 6 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC41383.1 - 0.00085 19.6 0.3 66 4.6 0.0 5.4 4 0 0 4 4 4 0 Ankyrin repeat GvpL_GvpF PF06386.11 EFC41384.1 - 0.028 14.4 0.1 0.028 14.4 0.1 1.7 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Nnf1 PF03980.14 EFC41384.1 - 3.7 8.0 11.9 0.22 11.9 3.0 2.7 2 0 0 2 2 2 0 Nnf1 14-3-3 PF00244.20 EFC41386.1 - 1.5e-68 230.7 5.5 1.6e-68 230.5 5.5 1.0 1 0 0 1 1 1 1 14-3-3 protein zinc_ribbon_16 PF17034.5 EFC41387.1 - 7.4e-16 58.5 20.6 7.4e-16 58.5 20.6 2.5 2 1 0 2 2 2 1 Zinc-ribbon like family zf-rbx1 PF12678.7 EFC41387.1 - 0.015 15.6 7.7 0.015 15.6 7.7 2.6 3 0 0 3 3 3 0 RING-H2 zinc finger domain WD40 PF00400.32 EFC41387.1 - 0.033 15.1 3.7 1 10.3 0.0 4.0 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF4905 PF16248.5 EFC41387.1 - 0.082 12.8 0.0 0.31 11.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4905) Zn_ribbon_17 PF17120.5 EFC41387.1 - 0.34 10.6 16.5 0.28 10.8 13.0 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF974 PF06159.13 EFC41388.1 - 1.7e-35 123.0 0.0 2.2e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) DNA_pol3_delta PF06144.13 EFC41389.1 - 0.0013 18.6 1.4 0.0015 18.3 1.4 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Acetyltransf_4 PF13420.7 EFC41389.1 - 0.13 12.4 0.4 1.5 8.9 0.4 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_22 PF13401.6 EFC41390.1 - 4.9e-07 30.1 0.2 3.2e-06 27.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 EFC41390.1 - 0.0074 16.7 0.1 0.025 15.0 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFC41390.1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_tran PF00005.27 EFC41390.1 - 0.026 15.0 0.4 0.092 13.3 0.4 2.0 1 1 0 1 1 1 0 ABC transporter AAA_19 PF13245.6 EFC41390.1 - 0.042 14.2 0.1 0.11 12.8 0.1 1.8 1 1 0 1 1 1 0 AAA domain Imm51 PF15595.6 EFC41390.1 - 0.12 12.3 0.8 0.27 11.2 0.8 1.5 1 0 0 1 1 1 0 Immunity protein 51 Cnd1 PF12717.7 EFC41390.1 - 0.14 12.2 2.4 0.32 11.0 0.7 2.3 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 RCC1_2 PF13540.6 EFC41392.1 - 6.7e-10 38.5 5.9 0.00018 21.2 0.0 4.2 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC41392.1 - 1.6e-07 31.8 0.0 0.11 13.1 0.0 5.1 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat Ras PF00071.22 EFC41393.1 - 7.1e-25 87.5 0.2 7.1e-25 87.5 0.2 2.6 3 0 0 3 3 3 1 Ras family Roc PF08477.13 EFC41393.1 - 4.2e-14 52.8 0.0 1.2e-13 51.3 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase OKR_DC_1_N PF03709.15 EFC41393.1 - 0.0098 16.2 0.0 0.023 15.0 0.0 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain Polysacc_deac_1 PF01522.21 EFC41393.1 - 0.037 13.9 3.2 5.8 6.8 0.1 3.3 3 0 0 3 3 3 0 Polysaccharide deacetylase MMR_HSR1 PF01926.23 EFC41393.1 - 0.072 13.2 0.0 0.25 11.4 0.0 2.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sec1 PF00995.23 EFC41394.1 - 2.7e-106 357.1 15.4 3.4e-106 356.8 15.4 1.1 1 0 0 1 1 1 1 Sec1 family PB1-F2 PF11986.8 EFC41394.1 - 0.041 14.1 0.5 0.093 13.0 0.5 1.6 1 0 0 1 1 1 0 Influenza A Proapoptotic protein Utp12 PF04003.12 EFC41395.1 - 2.6e-19 69.5 0.2 4.6e-19 68.7 0.2 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 EFC41395.1 - 3.5e-13 49.7 0.1 0.00038 20.7 0.0 6.9 5 2 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC41395.1 - 7.6e-13 48.7 18.3 0.012 16.4 0.0 10.1 10 1 0 10 10 10 3 WD domain, G-beta repeat WD40_like PF17005.5 EFC41395.1 - 3e-06 26.8 3.1 0.053 12.8 0.1 3.8 2 2 1 3 3 3 2 WD40-like domain WD40_3 PF15911.5 EFC41395.1 - 0.071 13.1 0.7 6.8 6.8 0.0 3.9 3 1 1 4 4 4 0 WD domain, G-beta repeat WI12 PF07107.11 EFC41395.1 - 0.16 12.1 0.2 0.39 10.9 0.2 1.6 1 0 0 1 1 1 0 Wound-induced protein WI12 Hemerythrin PF01814.23 EFC41396.1 - 4.9e-08 33.7 0.9 6.1e-08 33.4 0.9 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain EF-hand_like PF09279.11 EFC41396.1 - 0.021 15.3 0.2 0.1 13.1 0.0 2.1 1 1 1 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like N6_Mtase PF02384.16 EFC41397.1 - 2.6e-06 26.9 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase Methyltransf_31 PF13847.6 EFC41397.1 - 1.2e-05 25.2 0.2 3.8e-05 23.5 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC41397.1 - 0.00085 20.0 0.0 0.0014 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltrans_SAM PF10672.9 EFC41397.1 - 0.0019 17.4 0.1 0.0037 16.5 0.1 1.5 1 1 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase DOT1 PF08123.13 EFC41397.1 - 0.0028 17.2 0.0 0.004 16.7 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 LSM14 PF12701.7 EFC41397.1 - 0.0029 17.7 0.0 0.0059 16.7 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain MTS PF05175.14 EFC41397.1 - 0.0032 17.0 0.0 0.0069 16.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 EFC41397.1 - 0.018 14.7 0.0 0.04 13.6 0.0 1.5 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 PrmA PF06325.13 EFC41397.1 - 0.065 12.6 0.0 0.095 12.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 EFC41397.1 - 0.13 13.1 0.0 0.26 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain OTU PF02338.19 EFC41398.1 - 0.00044 20.7 0.0 0.00078 19.9 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease ubiquitin PF00240.23 EFC41398.1 - 0.00051 19.7 0.2 0.0019 17.9 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin family DUF5528 PF17666.1 EFC41399.1 - 0.067 13.1 6.3 0.022 14.7 2.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5528) VPS9 PF02204.18 EFC41400.1 - 3.6e-17 62.5 0.2 1.2e-16 60.8 0.2 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain HxlR PF01638.17 EFC41400.1 - 0.015 15.2 1.2 0.56 10.1 0.1 3.1 3 0 0 3 3 3 0 HxlR-like helix-turn-helix TetR PF13972.6 EFC41400.1 - 0.35 10.6 5.7 0.51 10.1 0.1 3.3 2 1 0 3 3 3 0 Bacterial transcriptional repressor VPS9 PF02204.18 EFC41401.1 - 1.2e-24 86.5 0.0 3.7e-24 84.9 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 EFC41401.1 - 5.7e-13 49.0 0.6 2.7e-12 46.8 0.6 2.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CbiK PF06180.11 EFC41401.1 - 0.011 15.0 0.3 0.011 15.0 0.3 1.7 2 0 0 2 2 2 0 Cobalt chelatase (CbiK) RL11D PF11088.8 EFC41401.1 - 0.043 14.1 0.6 14 6.1 0.0 2.9 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 VCBS PF13517.6 EFC41401.1 - 0.045 14.4 0.1 0.13 12.9 0.1 1.8 1 0 0 1 1 1 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella EF-hand_3 PF09069.11 EFC41401.1 - 0.11 12.9 0.5 1.7 9.1 0.0 2.8 2 0 0 2 2 2 0 EF-hand zf-MYND PF01753.18 EFC41403.1 - 0.00083 19.4 13.2 0.00083 19.4 13.2 2.7 2 1 0 2 2 2 1 MYND finger Med10 PF09748.9 EFC41403.1 - 1.1 9.2 5.5 1.2 9.1 0.2 3.3 3 0 0 3 3 3 0 Transcription factor subunit Med10 of Mediator complex SET PF00856.28 EFC41403.1 - 1.6 9.1 7.7 4.4 7.7 7.3 2.4 1 1 0 1 1 1 0 SET domain CDH1_2_SANT_HL1 PF18375.1 EFC41403.1 - 1.8 9.3 7.3 25 5.6 0.1 4.7 2 1 2 4 4 4 0 CDH1/2 SANT-Helical linker 1 Histone PF00125.24 EFC41405.1 - 0.0089 16.4 9.6 0.0089 16.4 9.6 1.5 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFC41405.1 - 0.021 15.1 1.1 0.042 14.1 1.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mitofilin PF09731.9 EFC41405.1 - 0.93 8.3 10.8 1 8.1 10.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ndc1_Nup PF09531.10 EFC41405.1 - 3.3 6.3 10.3 3.5 6.2 10.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3391 PF11871.8 EFC41405.1 - 4.9 7.7 8.7 21 5.7 8.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) DUF908 PF06012.12 EFC41405.1 - 5.8 6.2 11.2 7.5 5.9 11.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) QWRF PF04484.12 EFC41405.1 - 9.3 5.9 11.4 12 5.6 11.4 1.1 1 0 0 1 1 1 0 QWRF family bMG10 PF17973.1 EFC41406.1 - 2.7e-31 108.5 0.0 7e-31 107.1 0.0 1.8 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_BRD PF07703.14 EFC41406.1 - 1.8e-16 60.8 1.1 7.5e-16 58.8 0.4 2.6 2 0 0 2 2 2 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EFC41406.1 - 8.9e-16 57.5 0.1 1.5e-14 53.6 0.0 2.9 3 0 0 3 3 3 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFC41406.1 - 1.7e-09 38.0 0.0 7.3e-09 36.0 0.0 2.2 1 0 0 1 1 1 1 MG2 domain Big_5 PF13205.6 EFC41406.1 - 2.5e-09 37.8 4.9 0.0029 18.3 0.0 4.6 4 0 0 4 4 4 2 Bacterial Ig-like domain DUF11 PF01345.18 EFC41406.1 - 0.00098 19.4 0.1 0.0088 16.3 0.0 2.7 3 0 0 3 3 3 1 Domain of unknown function DUF11 Big_11 PF18200.1 EFC41406.1 - 0.068 13.1 0.6 7.4 6.6 0.0 3.7 2 1 1 3 3 3 0 Bacterial Ig-like domain Big_10 PF17964.1 EFC41406.1 - 0.099 12.6 0.1 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Bacterial Ig domain HMG_box PF00505.19 EFC41407.1 - 0.00072 19.9 0.8 0.0019 18.6 0.8 1.7 1 0 0 1 1 1 1 HMG (high mobility group) box Colicin_Pyocin PF01320.18 EFC41407.1 - 0.0036 17.4 1.0 0.035 14.2 0.0 2.7 3 0 0 3 3 3 1 Colicin immunity protein / pyocin immunity protein HMG_box_2 PF09011.10 EFC41407.1 - 0.0041 17.7 1.1 0.01 16.4 1.1 1.6 1 0 0 1 1 1 1 HMG-box domain Ras PF00071.22 EFC41408.1 - 5.1e-09 35.9 0.0 1.5e-08 34.4 0.0 1.7 1 1 0 1 1 1 1 Ras family F-box-like PF12937.7 EFC41408.1 - 0.00016 21.5 0.1 0.00027 20.8 0.1 1.4 1 0 0 1 1 1 1 F-box-like Roc PF08477.13 EFC41408.1 - 0.011 16.0 0.0 0.5 10.6 0.0 2.4 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC41408.1 - 0.012 15.4 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 F-box domain DUF4116 PF13475.6 EFC41409.1 - 2.2e-71 235.4 8.1 6.6e-14 51.4 0.0 8.3 3 2 6 10 10 10 10 Domain of unknown function (DUF4116) F-box PF00646.33 EFC41409.1 - 0.0017 18.2 0.3 0.006 16.4 0.3 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC41409.1 - 0.0028 17.5 0.2 0.0069 16.3 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFC41409.1 - 0.11 12.4 3.5 0.11 12.4 0.1 2.6 2 0 0 2 2 2 0 F-box Kelch_1 PF01344.25 EFC41411.1 - 4.5e-17 61.3 4.0 1.3e-07 31.1 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFC41411.1 - 1.2e-16 60.0 3.3 6.1e-07 29.2 0.0 4.8 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EFC41411.1 - 4.2e-15 55.4 7.2 9.1e-05 22.6 0.0 5.0 4 0 0 4 4 4 3 Kelch motif BTB PF00651.31 EFC41411.1 - 5e-13 49.2 4.6 2.4e-10 40.6 1.1 3.6 3 0 0 3 3 3 2 BTB/POZ domain Kelch_4 PF13418.6 EFC41411.1 - 1.3e-12 47.5 6.1 3e-08 33.5 0.1 4.5 4 0 0 4 4 4 2 Galactose oxidase, central domain RWD PF05773.22 EFC41411.1 - 3.2e-10 40.3 4.4 2.8e-09 37.3 2.1 3.4 2 0 0 2 2 2 1 RWD domain AhpC-TSA PF00578.21 EFC41411.1 - 5.5e-08 32.8 0.4 2.2e-07 30.8 0.2 2.3 2 0 0 2 2 2 1 AhpC/TSA family Kelch_3 PF13415.6 EFC41411.1 - 2.4e-06 27.7 9.8 0.43 10.9 0.3 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC41411.1 - 9.7e-06 25.5 3.8 0.13 12.3 0.0 4.5 4 0 0 4 4 4 1 Kelch motif Imm30 PF15565.6 EFC41411.1 - 0.079 13.0 2.7 0.54 10.4 2.7 2.5 1 0 0 1 1 1 0 Immunity protein 30 RCC1_2 PF13540.6 EFC41413.1 - 8.1e-08 31.9 6.1 7.3e-06 25.6 0.1 3.9 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC41413.1 - 8.4e-07 29.5 3.8 0.19 12.4 0.0 4.5 3 2 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC41413.1 - 0.05 13.8 0.1 7 7.0 0.1 2.9 2 1 0 2 2 2 0 Putative heavy-metal chelation ApoL PF05461.11 EFC41415.1 - 6.9e-10 38.8 4.6 5.7e-09 35.7 4.6 2.1 1 1 0 1 1 1 1 Apolipoprotein L DUF356 PF04009.12 EFC41415.1 - 0.24 11.7 1.4 0.4 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF356) SseC PF04888.12 EFC41415.1 - 0.87 9.1 10.6 3.2 7.2 10.4 1.9 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family Draxin PF15550.6 EFC41415.1 - 1.4 8.7 5.6 2.2 8.1 5.6 1.2 1 0 0 1 1 1 0 Draxin Thioredoxin PF00085.20 EFC41416.1 - 9.3e-51 170.1 1.0 8.2e-29 99.6 0.9 2.6 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_7 PF13899.6 EFC41416.1 - 6.3e-09 35.9 0.2 0.0013 18.8 0.1 2.7 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_9 PF14595.6 EFC41416.1 - 4.2e-07 29.8 1.2 0.013 15.3 0.2 2.5 2 1 0 2 2 2 2 Thioredoxin Thioredoxin_8 PF13905.6 EFC41416.1 - 1.3e-06 28.6 0.1 0.13 12.6 0.0 3.4 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_2 PF13098.6 EFC41416.1 - 3.7e-05 24.1 0.5 0.036 14.5 0.2 3.5 2 1 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 EFC41416.1 - 0.00083 18.8 0.1 0.082 12.2 0.1 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EFC41416.1 - 0.0094 15.9 0.1 3.3 7.6 0.0 2.7 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 EFC41416.1 - 0.027 14.2 0.1 11 5.8 0.0 2.5 2 0 0 2 2 2 0 Redoxin DUF4116 PF13475.6 EFC41417.1 - 4.8e-39 131.8 48.1 1.1e-12 47.4 0.3 10.4 8 2 2 11 11 11 9 Domain of unknown function (DUF4116) Ras PF00071.22 EFC41418.1 - 6.2e-57 191.7 0.0 7.2e-57 191.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41418.1 - 1.8e-22 79.8 0.0 2.7e-22 79.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41418.1 - 2.9e-08 33.4 0.0 4.9e-08 32.6 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF3047 PF11249.8 EFC41418.1 - 0.14 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3047) TniB PF05621.11 EFC41418.1 - 0.16 11.4 0.0 0.66 9.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein RBP_receptor PF14752.6 EFC41419.1 - 3.7e-12 45.7 16.8 3.7e-12 45.7 16.8 2.1 2 0 0 2 2 2 1 Retinol binding protein receptor Pox_A14 PF05767.12 EFC41419.1 - 0.078 13.1 0.3 0.078 13.1 0.3 4.8 4 2 1 5 5 5 0 Poxvirus virion envelope protein A14 HTH_24 PF13412.6 EFC41419.1 - 0.097 12.3 0.1 0.22 11.1 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Erf4 PF10256.9 EFC41419.1 - 1 9.5 5.4 0.39 10.8 0.7 2.8 2 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family ADH_N PF08240.12 EFC41420.1 - 1.5e-13 50.6 1.1 1.7e-12 47.1 1.1 2.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFC41420.1 - 7.8e-12 46.4 0.0 2.9e-11 44.5 0.0 2.1 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC41420.1 - 3.4e-10 40.0 0.0 6.9e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase YjeF_N PF03853.15 EFC41420.1 - 0.055 13.3 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus DUF2855 PF11017.8 EFC41420.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) Acyltransf_C PF16076.5 EFC41421.1 - 0.014 15.5 0.2 0.035 14.2 0.2 1.7 1 0 0 1 1 1 0 Acyltransferase C-terminus Syncollin PF15138.6 EFC41421.1 - 0.13 12.4 1.0 0.46 10.7 0.0 2.4 2 1 0 2 2 2 0 Syncollin Rhomboid PF01694.22 EFC41422.1 - 1.1e-30 106.6 8.7 1.1e-30 106.6 8.7 2.2 3 0 0 3 3 3 1 Rhomboid family TctB PF07331.11 EFC41422.1 - 5.2 7.3 17.3 1.3 9.3 8.7 2.5 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family RWP-RK PF02042.15 EFC41423.1 - 7.2e-07 29.1 2.0 8.2e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 RWP-RK domain Sigma70_r4_2 PF08281.12 EFC41423.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Phage_CII PF05269.11 EFC41423.1 - 0.027 14.7 0.3 0.099 12.9 0.1 1.9 2 0 0 2 2 2 0 Bacteriophage CII protein HTH_23 PF13384.6 EFC41423.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain LRR_4 PF12799.7 EFC41424.1 - 2.1e-06 28.0 29.6 0.012 16.0 0.5 7.8 3 2 5 8 8 8 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC41424.1 - 1e-05 25.2 19.8 0.026 14.5 0.3 8.9 10 0 0 10 10 10 2 Leucine Rich repeat Glyco_hydro_49 PF03718.13 EFC41424.1 - 0.064 13.2 1.5 9.1 6.3 0.1 2.6 1 1 1 2 2 2 0 Glycosyl hydrolase family 49 LRR_1 PF00560.33 EFC41424.1 - 1.2 10.0 18.6 11 7.0 0.2 7.7 6 1 2 8 8 8 0 Leucine Rich Repeat Pkinase PF00069.25 EFC41425.1 - 6.9e-10 38.7 0.5 1.4e-08 34.4 0.1 2.6 2 1 0 2 2 2 1 Protein kinase domain HATPase_c PF02518.26 EFC41426.1 - 8.9e-23 80.9 0.3 2.6e-22 79.4 0.3 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 2_5_RNA_ligase2 PF13563.6 EFC41426.1 - 2e-20 73.3 0.1 3.6e-20 72.4 0.1 1.4 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Response_reg PF00072.24 EFC41426.1 - 3.5e-18 65.8 0.3 7.6e-18 64.7 0.3 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC41426.1 - 2.2e-10 40.4 0.3 7.5e-10 38.7 0.3 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Pkinase PF00069.25 EFC41428.1 - 1.3e-26 93.6 0.9 1.8e-26 93.1 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41428.1 - 3e-16 59.5 0.8 6.3e-16 58.4 0.8 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC41428.1 - 0.012 14.4 0.1 0.025 13.4 0.1 1.4 1 0 0 1 1 1 0 Fungal protein kinase ART PF01129.18 EFC41428.1 - 0.022 14.0 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase APH PF01636.23 EFC41428.1 - 0.085 12.8 0.5 0.72 9.7 0.5 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family Trypan_PARP PF05887.11 EFC41429.1 - 1.7e-06 28.0 89.1 1.8e+04 -31.1 89.1 3.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Trypan_PARP PF05887.11 EFC41430.1 - 1.7e-06 28.1 96.6 0.047 13.7 27.3 3.1 1 1 1 2 2 2 1 Procyclic acidic repetitive protein (PARP) RWP-RK PF02042.15 EFC41433.1 - 3.6e-05 23.7 0.1 7.1e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 RWP-RK domain Glyco_hydro_20 PF00728.22 EFC41433.1 - 0.055 12.8 0.2 0.059 12.7 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain Sigma70_r4_2 PF08281.12 EFC41433.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 RWP-RK PF02042.15 EFC41434.1 - 3.8e-08 33.2 0.1 7.5e-08 32.2 0.1 1.5 1 0 0 1 1 1 1 RWP-RK domain Sigma70_r4_2 PF08281.12 EFC41434.1 - 0.02 14.5 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_37 PF13744.6 EFC41434.1 - 0.052 13.5 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Mga PF08280.11 EFC41434.1 - 0.053 13.5 0.4 0.13 12.3 0.4 1.7 1 1 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_23 PF13384.6 EFC41434.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain LysM PF01476.20 EFC41435.1 - 1.3e-09 37.9 0.1 5.3e-09 36.0 0.0 2.2 2 0 0 2 2 2 1 LysM domain LPMO_10 PF03067.15 EFC41435.1 - 1.4e-05 25.9 0.0 4e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 EFC41435.1 - 0.00034 20.6 0.5 0.0033 17.4 0.1 2.4 2 1 0 2 2 2 1 Glycosyl hydrolase family 61 DUF3146 PF11344.8 EFC41435.1 - 0.24 11.1 0.4 9.7 5.9 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3146) RWP-RK PF02042.15 EFC41436.1 - 3.8e-06 26.8 0.1 7.4e-06 25.9 0.1 1.5 1 0 0 1 1 1 1 RWP-RK domain TPR_2 PF07719.17 EFC41437.1 - 8.4e-14 50.5 9.1 0.0018 18.3 0.2 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41437.1 - 6.8e-10 38.3 11.1 0.088 12.7 0.1 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41437.1 - 4.9e-09 35.7 12.9 0.022 14.9 0.1 6.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC41437.1 - 8.7e-06 25.8 11.6 4.7 7.8 0.2 6.4 6 2 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41437.1 - 0.00012 21.8 1.3 2.6 8.3 0.0 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC41437.1 - 0.00022 21.8 0.1 1.9 9.5 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41437.1 - 0.0032 17.7 5.2 6.6 7.1 0.1 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat MIT PF04212.18 EFC41437.1 - 0.008 16.2 7.9 4.1 7.6 0.2 4.9 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 EFC41437.1 - 0.032 13.9 13.1 0.97 9.2 0.6 4.0 4 0 0 4 4 4 0 TPR repeat Fis1_TPR_C PF14853.6 EFC41437.1 - 0.042 13.9 0.4 0.12 12.4 0.4 1.8 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat KN17_SH3 PF18131.1 EFC41437.1 - 0.054 13.6 0.0 15 5.8 0.0 3.4 3 0 0 3 3 3 0 KN17 SH3-like C-terminal domain TPR_19 PF14559.6 EFC41437.1 - 0.067 13.7 3.3 1.5 9.4 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC41437.1 - 0.076 13.2 0.0 24 5.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC41437.1 - 0.17 12.6 0.2 23 5.7 0.0 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat SOTI PF17079.5 EFC41438.1 - 0.31 11.5 0.2 0.31 11.5 0.2 2.8 3 1 0 3 3 3 0 Male-specific protein scotti RGS PF00615.19 EFC41439.1 - 5.6e-11 42.8 11.1 1.7e-10 41.2 8.5 2.8 2 1 0 2 2 2 1 Regulator of G protein signaling domain START PF01852.19 EFC41439.1 - 0.025 14.0 0.0 0.057 12.8 0.0 1.6 1 0 0 1 1 1 0 START domain Zip PF02535.22 EFC41439.1 - 1.6 7.9 9.4 3 7.0 0.9 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter SAM_1 PF00536.30 EFC41440.1 - 0.013 15.9 0.1 0.68 10.4 0.0 3.1 2 1 0 3 3 3 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC41440.1 - 0.14 12.3 1.3 1.5 9.0 0.0 2.8 3 1 1 4 4 4 0 SAM domain (Sterile alpha motif) HALZ PF02183.18 EFC41442.1 - 0.13 12.5 15.4 0.14 12.4 5.0 2.9 2 1 0 2 2 2 0 Homeobox associated leucine zipper LUC7 PF03194.15 EFC41442.1 - 0.17 11.6 16.2 0.24 11.1 16.2 1.4 1 0 0 1 1 1 0 LUC7 N_terminus DUF1825 PF08855.10 EFC41442.1 - 0.53 10.2 10.1 0.89 9.5 1.6 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF1825) TPR_MLP1_2 PF07926.12 EFC41442.1 - 0.53 10.4 29.3 4 7.5 27.3 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF883 PF05957.13 EFC41442.1 - 3.1 8.5 6.5 2.6 8.7 4.3 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Pre-PUA PF17832.1 EFC41442.1 - 5.3 7.8 9.8 0.99 10.1 2.6 2.8 1 1 1 2 2 2 0 Pre-PUA-like domain FapA PF03961.13 EFC41442.1 - 7.3 5.1 23.0 1.4 7.4 18.0 1.8 1 1 0 2 2 2 0 Flagellar Assembly Protein A bZIP_1 PF00170.21 EFC41442.1 - 9.2 6.5 19.4 0.83 9.8 6.7 2.8 1 1 1 2 2 2 0 bZIP transcription factor LRR_4 PF12799.7 EFC41443.1 - 0.011 16.1 12.8 1.5 9.4 0.1 7.3 7 3 2 9 9 9 0 Leucine Rich repeats (2 copies) AP_endonuc_2 PF01261.24 EFC41445.1 - 2.8e-29 102.1 0.0 4.4e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AF-4 PF05110.13 EFC41445.1 - 0.073 11.2 31.5 0.084 11.0 31.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein GREB1 PF15782.5 EFC41445.1 - 0.34 8.0 17.7 0.38 7.8 17.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Glycoprotein_G PF00802.19 EFC41445.1 - 5 6.4 25.9 8.7 5.6 25.9 1.3 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G Macoilin PF09726.9 EFC41445.1 - 8 4.9 23.7 11 4.5 23.7 1.1 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 EFC41445.1 - 9.9 4.7 16.1 13 4.3 16.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Acetyltransf_3 PF13302.7 EFC41446.1 - 6.2e-15 56.1 0.1 1.2e-14 55.2 0.0 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain RGS PF00615.19 EFC41448.1 - 1.3e-08 35.1 0.1 3.7e-08 33.7 0.1 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF5056 PF16479.5 EFC41448.1 - 1 9.6 4.5 16 5.8 0.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5056) DUF3685 PF12452.8 EFC41448.1 - 2.2 8.0 5.5 0.38 10.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3685) Kelch_4 PF13418.6 EFC41449.1 - 4.7e-09 36.1 0.9 4.9e-05 23.2 0.0 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC41449.1 - 0.0025 17.4 0.0 0.11 12.1 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 EFC41449.1 - 0.0028 17.9 0.0 2.4 8.5 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFC41449.1 - 0.023 15.0 0.0 0.37 11.2 0.0 2.7 2 0 0 2 2 2 0 Galactose oxidase, central domain Thioredoxin PF00085.20 EFC41450.1 - 1.4e-23 82.8 0.0 3.9e-23 81.4 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFC41450.1 - 8.7e-08 32.6 0.0 3.1e-07 30.8 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin-like domain TPR_20 PF14561.6 EFC41450.1 - 7.1e-06 26.3 2.0 7.9e-05 22.9 0.2 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat Thioredoxin_7 PF13899.6 EFC41450.1 - 8.8e-06 25.8 0.0 3.7e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 EFC41450.1 - 1.1e-05 25.7 0.0 0.00014 22.1 0.0 2.5 2 1 0 2 2 2 1 Thioredoxin-like AhpC-TSA PF00578.21 EFC41450.1 - 0.00034 20.5 0.1 0.0017 18.3 0.0 2.2 2 1 0 2 2 2 1 AhpC/TSA family Thioredoxin_9 PF14595.6 EFC41450.1 - 0.037 13.8 0.1 0.097 12.4 0.0 1.8 2 0 0 2 2 2 0 Thioredoxin Prp19 PF08606.11 EFC41450.1 - 0.045 13.7 0.0 0.13 12.3 0.0 1.8 1 0 0 1 1 1 0 Prp19/Pso4-like Thioredoxin_3 PF13192.6 EFC41450.1 - 0.081 13.0 0.0 0.25 11.4 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin domain TPR_11 PF13414.6 EFC41450.1 - 0.098 12.4 1.0 0.34 10.6 0.1 2.3 2 0 0 2 2 2 0 TPR repeat RhoGEF PF00621.20 EFC41451.1 - 5.9e-36 124.4 8.0 5.9e-36 124.4 8.0 2.6 2 0 0 2 2 2 1 RhoGEF domain HNOB PF07700.15 EFC41451.1 - 0.037 14.0 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 Haem-NO-binding SlyX PF04102.12 EFC41451.1 - 1.6 9.4 6.2 5.1 7.8 2.3 2.9 2 0 0 2 2 2 0 SlyX p450 PF00067.22 EFC41452.1 - 7.6e-89 298.6 0.1 1.1e-88 298.0 0.1 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 EFC41452.1 - 9.2e-26 90.8 0.0 1.7e-25 89.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFC41452.1 - 4.6e-21 75.5 0.0 9.8e-21 74.5 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFC41452.1 - 4.3e-16 59.5 0.3 2.3e-15 57.2 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Pox_A6 PF04924.12 EFC41452.1 - 0.0077 15.2 0.3 0.0077 15.2 0.3 1.6 2 0 0 2 2 2 1 Poxvirus A6 protein ECH_1 PF00378.20 EFC41453.1 - 4.1e-45 154.0 0.0 5.1e-45 153.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC41453.1 - 1.2e-17 64.5 0.0 1.6e-17 64.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase adh_short PF00106.25 EFC41454.1 - 9.8e-14 51.3 0.0 2.1e-07 30.6 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC41454.1 - 2.3e-09 37.1 0.0 8.7e-06 25.5 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase OTT_1508_deam PF14441.6 EFC41454.1 - 0.016 15.2 1.0 0.044 13.8 1.0 1.7 1 0 0 1 1 1 0 OTT_1508-like deaminase DZR PF12773.7 EFC41454.1 - 0.66 10.1 2.8 1.9 8.6 2.8 1.7 1 0 0 1 1 1 0 Double zinc ribbon Ig_4 PF16680.5 EFC41454.1 - 3.2 8.1 6.3 0.8 10.0 1.2 2.6 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 delta chain 2OG-FeII_Oxy_2 PF13532.6 EFC41455.1 - 2.1e-17 64.0 0.1 3.9e-17 63.1 0.1 1.5 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NepR PF18557.1 EFC41455.1 - 0.18 11.5 0.1 0.32 10.7 0.1 1.4 1 0 0 1 1 1 0 Anti-sigma factor NepR GST_N_3 PF13417.6 EFC41456.1 - 2.2e-10 40.8 0.0 4.5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC41456.1 - 3.3e-05 23.8 0.0 4.7e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC41456.1 - 5.3e-05 23.4 0.1 0.00016 21.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC41456.1 - 0.0001 22.4 0.0 0.0002 21.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC41456.1 - 0.00015 22.0 0.2 0.00035 20.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 EFC41456.1 - 0.00048 19.9 0.0 0.0028 17.4 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC41456.1 - 0.0072 16.5 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Sec8_exocyst PF04048.14 EFC41456.1 - 0.012 15.5 0.1 0.023 14.6 0.0 1.5 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain Kelch_6 PF13964.6 EFC41457.1 - 0.00035 20.8 0.0 0.25 11.7 0.0 4.3 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 EFC41457.1 - 0.012 15.6 0.0 3.4 7.7 0.0 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain p450 PF00067.22 EFC41459.1 - 3e-50 171.3 0.4 4e-50 170.9 0.4 1.1 1 0 0 1 1 1 1 Cytochrome P450 PseudoU_synth_1 PF01416.20 EFC41459.1 - 0.061 13.8 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 tRNA pseudouridine synthase 2_5_RNA_ligase2 PF13563.6 EFC41460.1 - 1e-05 25.5 0.0 1.9e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EFC41460.1 - 0.0017 18.5 0.0 0.16 12.2 0.0 2.7 2 1 0 2 2 2 1 LigT like Phosphoesterase DUF1045 PF06299.12 EFC41460.1 - 0.0065 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1045) Cation_ATPase_N PF00690.26 EFC41460.1 - 0.091 12.5 0.6 4 7.2 0.2 2.4 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus CBFD_NFYB_HMF PF00808.23 EFC41461.1 - 2.7e-20 72.4 1.7 4.6e-20 71.7 1.7 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFC41461.1 - 2.4e-15 57.0 0.5 2.4e-15 57.0 0.5 2.1 3 0 0 3 3 3 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 EFC41461.1 - 0.16 12.3 0.3 0.4 11.0 0.3 1.7 1 0 0 1 1 1 0 CENP-S associating Centromere protein X RXT2_N PF08595.11 EFC41461.1 - 0.26 11.3 13.9 0.096 12.7 9.3 2.5 2 1 1 3 3 3 0 RXT2-like, N-terminal RGS PF00615.19 EFC41463.1 - 2e-11 44.2 6.5 2e-11 44.2 6.5 2.3 3 0 0 3 3 3 1 Regulator of G protein signaling domain PAS PF00989.25 EFC41463.1 - 0.0021 18.0 0.1 0.011 15.8 0.0 2.2 2 0 0 2 2 2 1 PAS fold DUF3487 PF11990.8 EFC41463.1 - 0.018 14.9 1.2 0.87 9.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) TMEM154 PF15102.6 EFC41463.1 - 0.06 13.3 8.1 0.18 11.7 0.7 2.9 3 0 0 3 3 3 0 TMEM154 protein family PAS_9 PF13426.7 EFC41463.1 - 0.062 13.6 1.2 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 PAS domain Endonuc_Holl PF10107.9 EFC41463.1 - 0.092 12.6 1.5 0.14 12.0 0.1 2.1 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase PulG PF11773.8 EFC41463.1 - 7.8 6.4 7.8 8.1 6.4 0.6 3.2 3 0 0 3 3 3 0 Type II secretory pathway pseudopilin RCC1_2 PF13540.6 EFC41465.1 - 4.4e-07 29.5 0.1 3.7e-06 26.6 0.1 2.7 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC41465.1 - 0.65 10.7 2.4 1 10.0 0.1 2.6 4 0 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat Serpin PF00079.20 EFC41466.1 - 1.2e-81 274.9 12.6 1.4e-81 274.7 12.6 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) WSD PF15613.6 EFC41466.1 - 0.044 14.3 0.5 0.15 12.6 0.3 1.9 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DUF3808 PF10300.9 EFC41468.1 - 9.2e-29 100.5 1.9 2.3e-28 99.2 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3808) TPR_19 PF14559.6 EFC41468.1 - 0.00025 21.5 0.1 0.05 14.1 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat Viral_protease PF08715.10 EFC41468.1 - 0.0012 18.2 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 Papain like viral protease ANAPC3 PF12895.7 EFC41468.1 - 0.052 13.8 3.3 0.16 12.2 0.0 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Nop PF01798.18 EFC41469.1 - 2.9e-83 278.9 0.3 2.9e-83 278.9 0.3 2.7 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 EFC41469.1 - 1.5e-15 57.3 0.2 1.5e-15 57.3 0.2 4.2 2 1 1 3 3 3 1 NOP5NT (NUC127) domain DUF4116 PF13475.6 EFC41472.1 - 3.6e-75 247.5 16.4 3.9e-12 45.7 0.0 13.4 7 5 10 17 17 17 17 Domain of unknown function (DUF4116) DUF5618 PF18498.1 EFC41472.1 - 0.028 14.6 0.1 0.97 9.6 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5618) dCache_1 PF02743.18 EFC41472.1 - 0.21 11.3 3.0 1 9.1 0.0 3.0 3 1 0 3 3 3 0 Cache domain S-methyl_trans PF02574.16 EFC41473.1 - 1.6e-46 159.3 0.0 3.7e-46 158.1 0.0 1.5 1 1 0 1 1 1 1 Homocysteine S-methyltransferase LRR_6 PF13516.6 EFC41475.1 - 2.5e-21 73.9 5.9 0.0052 16.7 0.1 6.8 7 0 0 7 7 7 6 Leucine Rich repeat LRR_4 PF12799.7 EFC41475.1 - 2e-19 69.4 4.6 3.6e-05 24.0 0.0 5.2 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC41475.1 - 1.7e-17 62.9 3.3 8.5e-09 35.1 0.1 4.1 4 1 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 EFC41475.1 - 2.4e-11 42.5 0.4 4.3 8.3 0.0 7.5 8 1 0 8 8 8 2 Leucine Rich Repeat DUF424 PF04242.13 EFC41475.1 - 0.0017 18.6 5.0 2.5 8.4 0.1 4.2 1 1 1 3 3 3 2 Protein of unknown function (DUF424) CLU_N PF15044.6 EFC41475.1 - 0.013 15.8 6.6 6.4 7.2 0.2 5.0 2 1 1 5 5 5 0 Mitochondrial function, CLU-N-term HHH_5 PF14520.6 EFC41475.1 - 0.018 15.6 0.7 0.35 11.5 0.2 3.1 2 1 0 2 2 2 0 Helix-hairpin-helix domain ApoB100_C PF12491.8 EFC41475.1 - 0.052 13.5 8.8 1.7 8.6 0.1 5.8 6 2 0 7 7 7 0 Apolipoprotein B100 C terminal HHH_9 PF17674.1 EFC41475.1 - 0.071 14.0 0.8 5.3 8.0 0.4 2.9 1 1 1 2 2 2 0 HHH domain Dynein_heavy PF03028.15 EFC41475.1 - 0.076 13.1 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain Lipase_GDSL_2 PF13472.6 EFC41476.1 - 2.3e-16 60.7 0.0 3e-16 60.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFC41476.1 - 3.7e-06 27.0 0.0 5.4e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase RWP-RK PF02042.15 EFC41477.1 - 9.2e-07 28.7 0.1 4.8e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 RWP-RK domain Nucleoside_tran PF01733.18 EFC41478.1 - 2e-43 149.0 24.9 9.2e-24 84.4 11.5 3.2 2 1 0 2 2 2 2 Nucleoside transporter Lectin_leg-like PF03388.13 EFC41479.1 - 1.4e-57 194.7 0.2 2.9e-57 193.7 0.2 1.5 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 EFC41479.1 - 1e-11 45.2 2.0 1e-11 45.2 2.0 1.7 2 0 0 2 2 2 1 Bacterial lectin Pes-10 PF07149.11 EFC41479.1 - 0.0027 16.8 4.5 0.0027 16.8 4.5 2.5 2 1 0 2 2 2 1 Pes-10 Baculo_PEP_C PF04513.12 EFC41479.1 - 0.0047 17.0 3.5 0.0047 17.0 3.5 1.8 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 EFC41479.1 - 0.014 15.4 2.9 0.014 15.4 2.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Hid1 PF12722.7 EFC41479.1 - 2.1 6.4 17.0 0.41 8.7 1.2 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein NPV_P10 PF05531.12 EFC41479.1 - 2.8 8.5 10.4 0.11 12.9 2.7 2.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 EFC41479.1 - 4.9 7.5 14.9 10 6.5 3.5 3.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Col_cuticle_N PF01484.17 EFC41479.1 - 6.8 6.8 15.2 13 6.0 0.2 4.4 4 0 0 4 4 4 0 Nematode cuticle collagen N-terminal domain FAM221 PF14753.6 EFC41480.1 - 5.8e-08 32.5 1.1 6.2e-08 32.4 1.1 1.2 1 0 0 1 1 1 1 Protein FAM221A/B Peptidase_S41 PF03572.18 EFC41481.1 - 2.7e-06 27.0 0.0 5.7e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Peptidase family S41 DUF817 PF05675.12 EFC41484.1 - 0.00024 20.9 1.1 0.00024 20.9 1.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF817) DUF2878 PF11086.8 EFC41484.1 - 0.024 14.9 18.5 0.24 11.6 4.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2878) DUF2339 PF10101.9 EFC41484.1 - 0.13 10.8 7.3 0.14 10.7 7.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) GWT1 PF06423.12 EFC41484.1 - 0.22 11.7 4.5 0.49 10.5 4.5 1.6 1 0 0 1 1 1 0 GWT1 SR-25 PF10500.9 EFC41485.1 - 0.0054 16.4 9.5 0.0054 16.4 9.5 2.2 1 1 1 2 2 2 1 Nuclear RNA-splicing-associated protein CdiI_2 PF18593.1 EFC41485.1 - 0.031 14.9 0.1 0.074 13.7 0.1 1.7 1 0 0 1 1 1 0 CdiI immunity protein Mlf1IP PF10248.9 EFC41485.1 - 0.081 12.9 4.9 0.048 13.6 3.0 1.6 2 0 0 2 2 2 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein SOBP PF15279.6 EFC41485.1 - 0.18 12.4 4.6 0.21 12.2 4.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein WD40 PF00400.32 EFC41487.1 - 8.2e-08 32.8 14.3 0.0075 17.1 0.1 5.0 5 1 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 EFC41487.1 - 7.9e-06 25.4 5.3 0.027 13.8 0.3 3.8 3 2 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 EFC41487.1 - 0.00015 20.6 3.0 0.022 13.4 0.2 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFC41487.1 - 0.0031 17.8 0.5 22 5.4 0.0 4.1 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Elongin_A PF06881.11 EFC41487.1 - 0.026 15.1 1.1 0.046 14.2 1.1 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A MutL_C PF08676.11 EFC41488.1 - 1.9e-08 34.2 0.0 5.6e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 MutL C terminal dimerisation domain JHY PF15261.6 EFC41488.1 - 1.9 9.2 8.9 15 6.3 5.7 2.4 1 1 1 2 2 2 0 Jhy protein 2-oxoacid_dh PF00198.23 EFC41489.1 - 1.6e-20 73.6 0.1 9.2e-10 38.4 0.0 2.1 2 0 0 2 2 2 2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Ribosomal_S17e PF00833.18 EFC41490.1 - 2.3e-55 185.8 4.0 2.8e-55 185.5 4.0 1.1 1 0 0 1 1 1 1 Ribosomal S17 EGF_2 PF07974.13 EFC41491.1 - 4.9e-23 81.2 106.0 0.0004 20.7 6.3 7.7 7 0 0 7 7 7 7 EGF-like domain NHL PF01436.21 EFC41491.1 - 1.4e-12 46.9 2.2 0.0055 16.7 0.0 5.5 5 0 0 5 5 5 3 NHL repeat DUF3377 PF11857.8 EFC41491.1 - 0.18 11.7 1.1 0.36 10.8 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ADH_zinc_N PF00107.26 EFC41492.1 - 7.1e-26 90.7 0.2 1.3e-25 89.8 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC41492.1 - 8.7e-23 81.8 0.2 2.5e-22 80.3 0.1 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC41492.1 - 5.6e-10 39.1 0.0 1.2e-09 38.0 0.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DAGK_cat PF00781.24 EFC41492.1 - 0.0034 17.0 0.1 0.0076 15.9 0.1 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain AlaDh_PNT_C PF01262.21 EFC41492.1 - 0.012 15.0 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_kinase PF01513.21 EFC41492.1 - 0.023 13.9 0.0 0.039 13.2 0.0 1.4 1 0 0 1 1 1 0 ATP-NAD kinase NAD_binding_7 PF13241.6 EFC41492.1 - 0.054 13.9 0.0 0.096 13.1 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding DUF4116 PF13475.6 EFC41493.1 - 4.9e-33 112.6 0.0 2e-13 49.9 0.0 3.8 2 1 1 4 4 4 3 Domain of unknown function (DUF4116) Bac_DnaA_C PF08299.11 EFC41493.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix DUF4116 PF13475.6 EFC41494.1 - 1.2e-107 351.5 11.5 1.6e-20 72.6 0.0 7.3 2 2 4 8 8 8 8 Domain of unknown function (DUF4116) DUF4853 PF16145.5 EFC41494.1 - 0.0056 16.8 0.1 17 5.6 0.0 3.6 2 1 0 3 3 3 1 Domain of unknown function (DUF4853) TnsD PF15978.5 EFC41494.1 - 0.062 12.3 0.5 0.44 9.5 0.1 2.0 1 1 0 2 2 2 0 Tn7-like transposition protein D Rsbr_N PF08678.10 EFC41494.1 - 0.073 13.1 0.0 7.4 6.7 0.0 3.7 3 1 1 4 4 4 0 Rsbr N terminal DUF2781 PF10914.8 EFC41495.1 - 5.8e-33 114.4 20.4 6.6e-33 114.2 20.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) DUF2407_C PF13373.6 EFC41496.1 - 4.5e-17 62.5 0.3 5e-17 62.4 0.3 1.0 1 0 0 1 1 1 1 DUF2407 C-terminal domain Vma12 PF11712.8 EFC41496.1 - 0.065 13.3 0.1 0.096 12.8 0.1 1.3 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Glyco_hydro_31 PF01055.26 EFC41497.1 - 1.3e-60 205.9 14.2 1.3e-60 205.9 14.2 1.6 2 1 0 2 2 2 1 Glycosyl hydrolases family 31 ABC_tran PF00005.27 EFC41498.1 - 1.1e-27 97.2 0.0 2.4e-27 96.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFC41498.1 - 1.1e-26 93.7 30.0 1.6e-26 93.2 30.0 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFC41498.1 - 4.1e-08 33.4 0.0 0.00021 21.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC41498.1 - 0.0023 17.9 0.0 0.0051 16.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC41498.1 - 0.052 13.6 0.1 0.13 12.4 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase PIRT PF15099.6 EFC41498.1 - 0.053 13.1 0.2 0.12 11.9 0.2 1.6 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family SMC_N PF02463.19 EFC41498.1 - 0.062 12.7 0.0 13 5.1 0.0 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFC41498.1 - 0.095 13.2 1.4 0.19 12.2 0.0 2.2 4 0 0 4 4 4 0 AAA domain CLP1_P PF16575.5 EFC41498.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop IstB_IS21 PF01695.17 EFC41498.1 - 0.16 11.7 0.0 4.8 6.9 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 EFC41498.1 - 0.25 11.1 0.0 0.43 10.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain PPR PF01535.20 EFC41499.1 - 1.6e-09 37.4 0.4 1 9.7 0.0 6.1 5 0 0 5 5 5 2 PPR repeat PPR_2 PF13041.6 EFC41499.1 - 6.5e-07 29.5 2.9 0.47 10.7 0.0 5.8 6 0 0 6 6 6 2 PPR repeat family TPR_19 PF14559.6 EFC41499.1 - 5.7e-05 23.6 0.1 0.035 14.6 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat PPR_3 PF13812.6 EFC41499.1 - 0.0021 18.1 6.1 5.3 7.2 0.0 5.5 6 0 0 6 6 6 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC41499.1 - 0.0052 16.5 0.7 4.5 7.1 0.0 4.0 4 0 0 4 4 4 1 PPR repeat KAsynt_C_assoc PF16197.5 EFC41499.1 - 0.088 13.3 1.6 0.29 11.6 1.0 2.2 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension TPR_2 PF07719.17 EFC41499.1 - 0.1 12.8 0.6 1.3e+02 3.1 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat SR-25 PF10500.9 EFC41499.1 - 0.28 10.8 13.0 0.51 9.9 13.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Interferon PF00143.19 EFC41500.1 - 0.049 13.8 3.3 0.47 10.6 1.0 2.6 2 0 0 2 2 2 0 Interferon alpha/beta domain Ribosomal_L14e PF01929.17 EFC41501.1 - 7.4e-15 55.2 1.1 1.7e-14 54.1 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L14 KOW PF00467.29 EFC41501.1 - 0.0028 17.5 0.1 0.0078 16.1 0.0 1.8 2 0 0 2 2 2 1 KOW motif SAC3_GANP PF03399.16 EFC41501.1 - 0.0051 16.2 0.2 0.0064 15.9 0.2 1.0 1 0 0 1 1 1 1 SAC3/GANP family DUF2027 PF09640.10 EFC41501.1 - 0.0087 15.7 0.2 0.011 15.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2027) Viral_env_E26 PF11050.8 EFC41501.1 - 0.047 13.0 1.6 0.058 12.7 1.6 1.1 1 0 0 1 1 1 0 Virus envelope protein E26 Pkinase PF00069.25 EFC41502.1 - 8.8e-68 228.5 0.0 1.2e-67 228.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41502.1 - 3.6e-31 108.4 0.0 5.2e-31 107.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC41502.1 - 2e-08 33.6 0.3 3e-08 33.0 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFC41502.1 - 6.9e-05 22.5 0.1 0.00013 21.6 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFC41502.1 - 0.0024 17.2 0.0 0.0048 16.2 0.0 1.6 1 1 1 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 EFC41502.1 - 0.034 13.2 0.1 0.055 12.5 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 4PPT_N PF17837.1 EFC41502.1 - 0.098 12.8 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain Choline_kinase PF01633.20 EFC41502.1 - 0.21 11.1 1.7 0.61 9.6 0.2 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase Stanniocalcin PF03298.13 EFC41503.1 - 0.017 14.4 0.5 0.037 13.4 0.5 1.5 1 0 0 1 1 1 0 Stanniocalcin family Metallophos PF00149.28 EFC41504.1 - 3.4e-05 24.5 0.0 5.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Gal4_dimer PF03902.13 EFC41505.1 - 0.033 14.3 0.1 0.092 12.9 0.1 1.7 1 1 0 1 1 1 0 Gal4-like dimerisation domain TrmO_C PF18389.1 EFC41505.1 - 0.16 12.1 0.2 0.74 10.0 0.1 2.1 1 1 1 2 2 2 0 TrmO C-terminal domain Actin PF00022.19 EFC41506.1 - 7e-92 308.1 0.0 2.7e-90 302.9 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC41506.1 - 0.011 14.6 0.0 1.2 7.9 0.1 2.2 2 0 0 2 2 2 0 MreB/Mbl protein HCNGP PF07818.13 EFC41507.1 - 6.8e-12 45.9 2.0 7.7e-12 45.7 2.0 1.2 1 0 0 1 1 1 1 HCNGP-like protein DNA_pol_alpha_N PF12254.8 EFC41507.1 - 0.012 15.7 0.4 0.026 14.6 0.4 1.6 1 1 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal RCC1_2 PF13540.6 EFC41508.1 - 5.1e-19 67.6 0.3 3.6e-11 42.5 0.0 4.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC41508.1 - 5.4e-14 52.5 0.1 4.8e-06 27.1 0.5 4.2 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Rieske_2 PF13806.6 EFC41508.1 - 0.14 12.1 0.1 7 6.7 0.0 2.7 3 0 0 3 3 3 0 Rieske-like [2Fe-2S] domain Ribosomal_L20 PF00453.18 EFC41509.1 - 1.6e-32 111.7 0.6 2.7e-32 111.1 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L20 Topoisom_I_N PF02919.15 EFC41509.1 - 0.05 13.1 1.6 0.11 12.0 0.2 1.9 2 0 0 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Polyketide_cyc2 PF10604.9 EFC41510.1 - 1.6e-12 47.9 0.0 2e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 EFC41510.1 - 0.023 14.9 0.0 0.027 14.7 0.0 1.3 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport ubiquitin PF00240.23 EFC41512.1 - 1e-61 204.6 6.5 8.4e-31 105.5 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC41512.1 - 1.5e-28 98.4 8.3 1.4e-14 53.7 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC41512.1 - 3.3e-08 33.3 0.3 0.0061 16.5 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 EFC41512.1 - 6.1e-08 33.0 3.7 0.01 16.2 0.2 3.0 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC41512.1 - 6.3e-08 32.7 0.3 0.0046 17.1 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC41512.1 - 1.1e-06 29.0 2.2 0.026 14.9 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC41512.1 - 1.7e-06 28.5 0.1 0.02 15.5 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC41512.1 - 0.00069 19.6 7.3 6.1 7.0 0.2 4.0 2 2 2 4 4 4 2 Ubiquitin-like domain DUF3861 PF12977.7 EFC41512.1 - 0.098 12.8 0.5 0.84 9.8 0.1 2.2 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) Raf1_HTH PF18579.1 EFC41512.1 - 0.1 12.3 0.0 6.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain Coagulin PF02035.15 EFC41512.1 - 0.13 12.2 0.4 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin F-box-like PF12937.7 EFC41513.1 - 0.038 13.9 0.0 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 F-box-like F-box_5 PF18511.1 EFC41513.1 - 0.14 11.8 0.0 0.31 10.6 0.0 1.6 1 0 0 1 1 1 0 F-box p450 PF00067.22 EFC41514.1 - 5.1e-46 157.4 0.2 1.1e-45 156.2 0.2 1.5 1 1 0 1 1 1 1 Cytochrome P450 SAM_2 PF07647.17 EFC41515.1 - 2e-10 40.6 0.4 4.8e-10 39.4 0.4 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC41515.1 - 5e-10 39.7 0.3 9.9e-10 38.7 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Peptidase_C97 PF05903.14 EFC41515.1 - 0.0027 17.6 0.1 0.0067 16.3 0.1 1.7 1 0 0 1 1 1 1 PPPDE putative peptidase domain SAM_3 PF18016.1 EFC41515.1 - 0.019 14.8 0.1 0.062 13.1 0.1 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Presenilin PF01080.17 EFC41515.1 - 1.3 7.7 6.6 2 7.1 6.6 1.2 1 0 0 1 1 1 0 Presenilin DUF1963 PF09234.10 EFC41516.1 - 6.5e-15 56.2 0.4 2.2e-14 54.4 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1963) Actin PF00022.19 EFC41516.1 - 3.7e-09 35.7 0.0 0.00072 18.3 0.0 2.1 2 0 0 2 2 2 2 Actin 2OG-FeII_Oxy_3 PF13640.6 EFC41516.1 - 2.4e-07 31.5 0.0 6.3e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Spt4 PF06093.13 EFC41517.1 - 3.1e-25 88.1 0.1 4.4e-25 87.6 0.1 1.2 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger TackOD1 PF18551.1 EFC41517.1 - 0.0069 16.1 0.2 0.0093 15.7 0.2 1.2 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Ephrin_rec_like PF07699.13 EFC41517.1 - 1.1 9.0 7.0 2.1 8.2 4.7 2.4 2 1 0 2 2 2 0 Putative ephrin-receptor like DEAD_2 PF06733.15 EFC41518.1 - 5.6e-49 166.1 0.0 9.8e-49 165.3 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 EFC41518.1 - 1.9e-48 164.9 0.1 8.6e-48 162.7 0.0 2.2 3 0 0 3 3 3 1 Helicase C-terminal domain HBB PF06777.11 EFC41518.1 - 8.4e-31 107.1 0.3 1.3e-27 96.7 0.0 2.7 2 0 0 2 2 2 2 Helical and beta-bridge domain PhoH PF02562.16 EFC41518.1 - 0.018 14.5 0.2 1.2 8.6 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_22 PF13401.6 EFC41518.1 - 0.029 14.7 0.9 4.5 7.5 0.0 3.3 3 0 0 3 3 3 0 AAA domain Peptidase_C58 PF03543.14 EFC41518.1 - 0.033 13.9 0.1 0.084 12.6 0.0 1.7 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen SNF2_N PF00176.23 EFC41518.1 - 0.12 11.1 0.1 1.3 7.7 0.1 2.2 1 1 0 1 1 1 0 SNF2 family N-terminal domain ResIII PF04851.15 EFC41518.1 - 0.12 12.3 0.0 5.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EFC41518.1 - 0.12 11.5 0.0 4.3 6.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) PP-binding_2 PF14573.6 EFC41518.1 - 0.16 12.2 0.0 22 5.4 0.0 2.6 2 0 0 2 2 2 0 Acyl-carrier Metallophos PF00149.28 EFC41519.1 - 5.3e-36 125.0 0.2 9.7e-36 124.2 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase LRR_8 PF13855.6 EFC41520.1 - 1.4e-17 63.2 17.0 1.9e-07 30.7 2.5 4.5 3 1 1 4 4 4 4 Leucine rich repeat LRR_6 PF13516.6 EFC41520.1 - 9.6e-17 59.6 18.5 0.059 13.5 0.0 9.1 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.7 EFC41520.1 - 1.6e-13 50.6 28.3 0.00029 21.2 1.1 7.1 2 2 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41520.1 - 2.5e-10 39.4 7.0 2.9 8.8 0.1 8.4 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC41520.1 - 0.00031 20.3 8.2 0.14 11.7 0.3 3.3 1 1 2 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC41520.1 - 0.0061 16.4 0.7 0.26 11.1 0.2 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF4347) F-box PF00646.33 EFC41520.1 - 0.017 15.0 0.1 0.041 13.8 0.1 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC41520.1 - 0.053 13.4 0.6 0.1 12.5 0.1 1.8 2 0 0 2 2 2 0 F-box-like DUF4116 PF13475.6 EFC41521.1 - 2.9e-162 526.3 100.3 2.3e-15 56.0 0.5 20.0 12 5 8 21 21 21 21 Domain of unknown function (DUF4116) PAS_6 PF08348.11 EFC41521.1 - 0.056 13.3 0.1 6.7 6.6 0.0 4.1 4 1 0 4 4 4 0 YheO-like PAS domain Phage_FRD3 PF05798.11 EFC41521.1 - 0.085 13.1 0.1 0.31 11.3 0.1 2.0 1 0 0 1 1 1 0 Bacteriophage FRD3 protein Fe_hyd_lg_C PF02906.14 EFC41522.1 - 1.3e-84 283.7 0.0 2.2e-83 279.7 0.0 2.2 2 0 0 2 2 2 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 EFC41522.1 - 1.4e-20 73.1 6.6 3.3e-20 71.9 6.6 1.7 1 0 0 1 1 1 1 Iron hydrogenase small subunit NADH-G_4Fe-4S_3 PF10588.9 EFC41522.1 - 1.3e-13 50.2 0.8 1.3e-13 50.2 0.8 2.4 2 0 0 2 2 1 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer4 PF00037.27 EFC41522.1 - 5.2e-08 32.4 19.3 2.9e-05 23.7 3.4 3.3 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_8 PF13183.6 EFC41522.1 - 5.5e-07 29.9 6.6 5.5e-07 29.9 6.6 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFC41522.1 - 6.4e-07 29.9 12.0 0.0011 19.6 0.1 3.6 3 1 0 3 3 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 EFC41522.1 - 8.1e-07 29.1 10.8 6.1e-06 26.3 10.8 2.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFC41522.1 - 2.7e-06 27.2 20.3 0.00096 19.1 3.1 3.3 3 0 0 3 3 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 EFC41522.1 - 3.3e-06 27.2 7.0 3.3e-06 27.2 7.0 2.9 3 1 0 3 3 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFC41522.1 - 3.2e-05 24.0 23.3 7e-05 22.9 13.7 3.6 3 1 1 4 4 3 2 4Fe-4S dicluster domain Fer2_4 PF13510.6 EFC41522.1 - 7.7e-05 22.7 0.0 0.00061 19.8 0.0 2.6 3 1 0 3 3 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_16 PF13484.6 EFC41522.1 - 8.9e-05 23.4 11.2 0.00074 20.4 0.2 4.1 4 0 0 4 4 3 1 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 EFC41522.1 - 0.00058 20.3 6.9 0.00058 20.3 6.9 2.9 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 EFC41522.1 - 0.0082 16.2 2.7 0.0082 16.2 2.7 3.8 4 0 0 4 4 3 2 4Fe-4S binding domain Fer4_18 PF13746.6 EFC41522.1 - 0.019 15.2 9.6 0.067 13.4 0.9 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 EFC41522.1 - 0.028 15.0 12.2 1.1 9.9 1.7 2.9 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 EFC41522.1 - 0.029 15.1 8.1 0.43 11.3 0.3 3.0 2 1 0 2 2 2 0 4Fe-4S single cluster domain Fer2 PF00111.27 EFC41522.1 - 0.031 14.2 0.0 0.031 14.2 0.0 3.4 3 0 0 3 3 2 0 2Fe-2S iron-sulfur cluster binding domain Fer4_3 PF12798.7 EFC41522.1 - 0.033 15.1 5.1 0.033 15.1 5.1 3.6 3 0 0 3 3 3 0 4Fe-4S binding domain RestrictionMunI PF11407.8 EFC41522.1 - 0.11 12.2 0.0 3.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Type II restriction enzyme MunI Fer4_22 PF17179.4 EFC41522.1 - 0.52 11.2 12.2 0.57 11.1 0.1 3.5 2 1 1 3 3 3 0 4Fe-4S dicluster domain Ribosomal_S17 PF00366.20 EFC41522.1 - 0.84 9.8 3.0 0.61 10.2 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein S17 AAA_6 PF12774.7 EFC41523.1 - 1.9e-142 474.0 0.1 1.9e-142 474.0 0.1 2.3 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EFC41523.1 - 2e-140 469.1 17.1 2e-140 469.1 17.1 4.9 5 0 0 5 5 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EFC41523.1 - 2.4e-116 389.1 19.2 2.4e-116 389.1 19.2 5.4 5 0 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFC41523.1 - 8.8e-86 287.4 0.9 3.5e-85 285.5 0.9 2.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFC41523.1 - 2.5e-73 245.8 4.2 2.5e-73 245.8 4.2 5.2 5 0 0 5 5 4 1 ATP-binding dynein motor region Dynein_C PF18199.1 EFC41523.1 - 6e-72 242.5 0.1 6e-72 242.5 0.1 3.6 4 0 0 4 4 4 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 EFC41523.1 - 3e-64 215.8 4.7 1.9e-58 197.0 0.1 4.9 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC41523.1 - 1.7e-41 141.8 0.1 6.4e-41 139.9 0.1 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC41523.1 - 1.2e-40 138.3 0.1 2e-37 127.9 0.0 4.5 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 EFC41523.1 - 1.2e-36 126.5 9.9 2.4e-36 125.5 9.9 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 EFC41523.1 - 1.9e-23 82.9 1.8 3.7e-22 78.8 0.1 3.6 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFC41523.1 - 3.8e-21 75.6 0.1 1.2e-05 25.3 0.0 5.6 5 0 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFC41523.1 - 3.2e-19 69.0 0.1 3.1e-18 65.8 0.1 2.9 1 0 0 1 1 1 1 AAA+ lid domain VPS9 PF02204.18 EFC41523.1 - 2.8e-17 62.8 2.3 2.4e-16 59.8 0.1 3.8 3 0 0 3 3 3 1 Vacuolar sorting protein 9 (VPS9) domain AAA PF00004.29 EFC41523.1 - 1.6e-08 35.1 1.1 0.067 13.6 0.0 5.0 5 0 0 5 5 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC41523.1 - 6.5e-07 29.9 0.1 0.21 12.0 0.0 5.1 4 0 0 4 4 4 2 AAA ATPase domain RNA_helicase PF00910.22 EFC41523.1 - 7.2e-05 23.1 2.3 0.62 10.5 0.0 5.0 4 0 0 4 4 3 1 RNA helicase AAA_22 PF13401.6 EFC41523.1 - 0.00044 20.5 2.2 4.1 7.7 0.0 5.1 5 0 0 5 5 4 2 AAA domain AAA_18 PF13238.6 EFC41523.1 - 0.00051 20.6 3.1 1.6 9.3 0.0 5.4 5 0 0 5 5 3 1 AAA domain AAA_30 PF13604.6 EFC41523.1 - 0.00067 19.4 0.2 1.5 8.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain Roc PF08477.13 EFC41523.1 - 0.0027 17.9 0.1 0.18 12.0 0.1 3.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 EFC41523.1 - 0.053 13.9 1.8 0.61 10.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain SulA PF03846.14 EFC41523.1 - 0.065 13.2 0.3 1.3 8.9 0.1 2.7 2 0 0 2 2 2 0 Cell division inhibitor SulA TsaE PF02367.17 EFC41523.1 - 0.13 12.3 2.4 3.8 7.5 0.0 3.9 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EFC41523.1 - 0.25 11.0 2.0 1.3 8.7 0.1 2.9 4 0 0 4 4 3 0 Sigma-54 interaction domain T2SSE PF00437.20 EFC41523.1 - 0.41 9.7 2.0 16 4.5 0.1 3.2 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_29 PF13555.6 EFC41523.1 - 0.43 10.4 6.1 11 5.8 0.1 3.9 4 0 0 4 4 4 0 P-loop containing region of AAA domain REJ PF02010.15 EFC41524.1 - 3.9e-40 138.0 141.6 1.1e-14 54.1 27.4 7.8 5 3 2 8 8 8 6 REJ domain EGF_2 PF07974.13 EFC41524.1 - 3.1e-21 75.4 598.8 8.8e-05 22.8 7.8 36.9 38 1 0 38 38 38 27 EGF-like domain PUD PF03714.14 EFC41524.1 - 0.0021 18.9 0.0 7.4 7.5 0.0 3.4 2 0 0 2 2 2 2 Bacterial pullanase-associated domain SSTK-IP PF15836.5 EFC41524.1 - 0.0063 16.6 1.3 0.061 13.5 0.2 3.2 2 0 0 2 2 2 1 SSTK-interacting protein, TSSK6-activating co-chaperone protein Ribosomal_L31 PF01197.18 EFC41524.1 - 3.3 8.0 20.7 4.3 7.6 1.1 5.1 4 0 0 4 4 4 0 Ribosomal protein L31 DUF4116 PF13475.6 EFC41525.1 - 6.6e-78 256.3 5.8 5.4e-16 58.1 0.0 7.7 2 2 6 8 8 8 8 Domain of unknown function (DUF4116) Ank_2 PF12796.7 EFC41525.1 - 0.0023 18.5 2.7 1.1 9.9 0.5 3.0 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Pentapeptide_4 PF13599.6 EFC41526.1 - 8.5e-23 80.3 83.1 7.2e-08 32.5 15.1 4.5 1 1 4 5 5 5 5 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 EFC41526.1 - 5.1e-21 74.0 39.8 4.1e-08 32.7 4.5 7.4 5 1 3 8 8 8 6 Pentapeptide repeats (8 copies) TLD PF07534.16 EFC41526.1 - 5.5e-17 62.3 1.7 5.5e-17 62.3 1.7 2.3 2 0 0 2 2 2 1 TLD Pentapeptide_3 PF13576.6 EFC41526.1 - 4.9e-10 39.4 45.1 3.1e-07 30.5 5.9 7.1 5 2 2 7 7 7 3 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC41526.1 - 5.4e-06 26.7 0.3 2.8e-05 24.4 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain TcpS PF17456.2 EFC41526.1 - 0.042 13.9 3.8 0.11 12.6 3.8 1.6 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S zf-RING_5 PF14634.6 EFC41526.1 - 0.11 12.5 9.6 0.11 12.4 4.8 3.4 2 0 0 2 2 2 0 zinc-RING finger domain OmpH PF03938.14 EFC41526.1 - 0.16 12.3 13.2 0.31 11.4 13.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Prp18 PF02840.15 EFC41526.1 - 0.37 10.9 2.6 0.79 9.8 2.6 1.5 1 0 0 1 1 1 0 Prp18 domain Sds3 PF08598.11 EFC41526.1 - 1.8 8.5 15.2 0.096 12.7 9.5 1.8 2 1 0 2 2 2 0 Sds3-like zf-C3HC4_2 PF13923.6 EFC41526.1 - 2 8.3 11.3 0.42 10.5 5.8 3.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) cobW PF02492.19 EFC41527.1 - 1.7e-53 180.8 0.4 3.7e-53 179.7 0.4 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain TPR_2 PF07719.17 EFC41527.1 - 8.9e-16 56.7 0.5 1.5e-05 24.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41527.1 - 1.3e-15 56.4 3.3 4.2e-07 29.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41527.1 - 1.5e-11 43.5 3.2 0.0015 18.5 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC41527.1 - 1.3e-08 34.6 0.4 4.9e-05 23.4 0.0 3.3 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41527.1 - 2e-07 30.6 2.7 0.0024 17.5 0.5 3.3 3 0 0 3 3 3 2 TPR repeat TPR_16 PF13432.6 EFC41527.1 - 9.5e-05 23.0 0.0 0.3 11.8 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC41527.1 - 0.001 19.5 0.0 0.078 13.5 0.0 2.5 1 1 0 2 2 2 1 Tetratricopeptide repeat MobB PF03205.14 EFC41527.1 - 0.0013 18.6 0.2 0.014 15.2 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 EFC41527.1 - 0.0015 18.5 3.1 0.04 13.8 0.1 2.7 2 1 0 2 2 2 1 RsgA GTPase TPR_7 PF13176.6 EFC41527.1 - 0.0015 18.4 0.1 0.29 11.3 0.0 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat T2SSE PF00437.20 EFC41527.1 - 0.0017 17.5 1.7 0.003 16.6 0.1 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein ATPase_2 PF01637.18 EFC41527.1 - 0.0049 16.8 0.0 0.0049 16.8 0.0 2.4 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea TPR_12 PF13424.6 EFC41527.1 - 0.005 17.1 0.6 0.27 11.5 0.1 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC41527.1 - 0.005 17.4 0.1 20 6.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC41527.1 - 0.0057 17.4 0.0 0.24 12.3 0.0 2.8 1 1 2 3 3 3 1 Tetratricopeptide repeat NAD_binding_6 PF08030.12 EFC41527.1 - 0.0077 16.4 0.6 0.022 14.9 0.6 1.8 1 0 0 1 1 1 1 Ferric reductase NAD binding domain TsaE PF02367.17 EFC41527.1 - 0.0087 16.1 0.1 0.029 14.3 0.1 1.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 EFC41527.1 - 0.0091 15.8 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 EFC41527.1 - 0.012 14.6 0.2 1.3 7.9 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_14 PF13173.6 EFC41527.1 - 0.027 14.5 0.0 0.16 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain ANAPC3 PF12895.7 EFC41527.1 - 0.035 14.3 0.6 0.1 12.9 0.6 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 AAA_16 PF13191.6 EFC41527.1 - 0.049 14.0 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain dNK PF01712.19 EFC41527.1 - 0.05 13.5 2.3 0.37 10.6 0.0 2.5 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_33 PF13671.6 EFC41527.1 - 0.056 13.6 0.2 0.2 11.8 0.0 2.1 3 0 0 3 3 2 0 AAA domain Fis1_TPR_C PF14853.6 EFC41527.1 - 0.07 13.2 0.9 0.44 10.7 0.0 2.7 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat ABC_tran PF00005.27 EFC41527.1 - 0.2 12.2 0.1 0.2 12.2 0.1 2.7 3 1 0 3 3 3 0 ABC transporter RGS PF00615.19 EFC41528.1 - 2e-05 24.8 4.1 2e-05 24.8 4.1 2.3 2 1 1 3 3 3 1 Regulator of G protein signaling domain DUF2700 PF10912.8 EFC41528.1 - 0.0025 17.8 1.2 0.0025 17.8 1.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2700) DUF3377 PF11857.8 EFC41528.1 - 0.023 14.6 1.1 0.07 13.1 1.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EFC41528.1 - 0.024 14.6 1.3 0.024 14.6 1.3 2.0 2 0 0 2 2 2 0 TMEM154 protein family Enterotoxin_ST PF02048.16 EFC41528.1 - 0.16 12.4 0.1 0.71 10.4 0.0 2.2 2 0 0 2 2 2 0 Heat-stable enterotoxin ST Col_cuticle_N PF01484.17 EFC41528.1 - 5.5 7.1 10.2 3.6 7.7 0.0 3.0 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain Polyketide_cyc2 PF10604.9 EFC41529.1 - 0.064 13.5 0.0 0.15 12.3 0.0 1.8 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PEARLI-4 PF05278.12 EFC41530.1 - 0.21 11.1 1.5 15 5.1 0.0 2.5 2 1 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4252 PF14060.6 EFC41531.1 - 0.025 14.5 0.5 0.034 14.1 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) WBP-1 PF11669.8 EFC41531.1 - 0.035 14.7 0.1 0.052 14.2 0.1 1.3 1 0 0 1 1 1 0 WW domain-binding protein 1 PMC2NT PF08066.12 EFC41531.1 - 0.072 13.8 1.1 0.12 13.1 0.2 1.7 1 1 1 2 2 2 0 PMC2NT (NUC016) domain LuxT_C PF18285.1 EFC41531.1 - 0.077 13.5 0.1 0.19 12.3 0.1 1.7 1 1 1 2 2 2 0 Tetracycline repressor LuxT C-terminal domain CM1 PF03026.15 EFC41531.1 - 0.084 12.2 0.1 0.09 12.1 0.1 1.1 1 0 0 1 1 1 0 Influenza C virus M1 protein UPF0565 PF10561.9 EFC41532.1 - 1.3e-11 44.2 8.9 0.00015 21.1 0.1 3.1 2 1 1 3 3 3 3 Uncharacterised protein family UPF0565 RGS PF00615.19 EFC41533.1 - 9.4e-07 29.1 2.5 3.6e-06 27.2 2.5 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain PAPS_reduct PF01507.19 EFC41533.1 - 0.059 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Izumo-Ig PF16706.5 EFC41534.1 - 0.092 12.8 1.7 3.4 7.8 0.0 3.1 3 0 0 3 3 3 0 Izumo-like Immunoglobulin domain CxxCxxCC PF03692.15 EFC41534.1 - 0.26 12.0 8.8 0.88 10.3 0.2 3.0 3 0 0 3 3 3 0 Putative zinc- or iron-chelating domain p450 PF00067.22 EFC41536.1 - 3.4e-46 157.9 3.0 3.6e-46 157.9 0.2 2.2 2 0 0 2 2 2 1 Cytochrome P450 PAS_3 PF08447.12 EFC41536.1 - 2.9e-05 24.3 0.0 8.4e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 EFC41536.1 - 0.00014 21.9 13.0 0.00031 20.8 13.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_9 PF13426.7 EFC41536.1 - 0.0094 16.2 0.0 0.035 14.3 0.0 2.0 1 0 0 1 1 1 1 PAS domain Fe_dep_repr_C PF02742.15 EFC41536.1 - 0.14 12.3 0.0 0.94 9.6 0.0 2.3 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain RGS PF00615.19 EFC41537.1 - 5.7e-09 36.3 1.6 2.7e-08 34.1 1.6 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 EFC41538.1 - 5.2e-11 42.8 2.9 1.1e-10 41.8 2.9 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain NHL PF01436.21 EFC41538.1 - 8.8e-07 28.7 0.4 0.23 11.6 0.1 4.3 3 0 0 3 3 3 2 NHL repeat GPS PF01825.21 EFC41538.1 - 4.2e-06 27.2 6.1 4.2e-06 27.2 6.1 2.1 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif PTP_tm PF18861.1 EFC41538.1 - 0.0057 16.7 1.1 0.0057 16.7 1.1 2.7 3 0 0 3 3 3 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J ANAPC4_WD40 PF12894.7 EFC41538.1 - 0.13 12.6 0.4 11 6.4 0.0 3.9 4 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EFC41538.1 - 0.13 12.2 0.4 2.7 8.1 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat LVIVD PF08309.11 EFC41538.1 - 0.28 10.5 6.8 4 6.8 0.3 3.7 3 0 0 3 3 3 0 LVIVD repeat Mce4_CUP1 PF11887.8 EFC41538.1 - 0.83 9.1 4.0 1.6 8.2 4.0 1.4 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF4116 PF13475.6 EFC41540.1 - 9.2e-77 252.6 13.3 3.5e-13 49.1 0.0 10.7 8 2 2 11 11 11 9 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 EFC41540.1 - 0.0052 16.9 0.0 30 4.7 0.0 4.1 4 0 0 4 4 4 2 Rsbr N terminal EamA PF00892.20 EFC41544.1 - 8.4e-19 68.1 38.0 1.2e-12 48.2 16.7 3.0 2 1 0 2 2 2 2 EamA-like transporter family DUF2371 PF10177.9 EFC41544.1 - 0.0073 16.5 0.7 1.3 9.2 0.2 2.7 2 0 0 2 2 2 2 Uncharacterised conserved protein (DUF2371) MGC-24 PF05283.11 EFC41544.1 - 0.048 14.1 0.1 0.13 12.8 0.1 1.7 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CcmH PF03918.14 EFC41544.1 - 0.35 10.2 1.0 1.2 8.4 0.0 2.3 3 0 0 3 3 3 0 Cytochrome C biogenesis protein Orn_Arg_deC_N PF02784.16 EFC41545.1 - 3.5e-69 232.9 0.2 3.7e-51 173.9 0.0 2.5 3 0 0 3 3 3 2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFC41545.1 - 2e-13 50.4 0.9 4.9e-13 49.1 0.6 2.1 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 EFC41545.1 - 0.00096 18.8 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain AP_endonuc_2 PF01261.24 EFC41545.1 - 0.0015 18.0 0.0 0.0074 15.7 0.0 2.1 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel RCC1 PF00415.18 EFC41546.1 - 2.5e-27 95.2 0.1 0.00015 22.3 0.1 8.6 9 0 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC41546.1 - 4.2e-23 80.6 15.5 2.4e-09 36.8 0.2 7.0 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC41546.1 - 0.0028 17.9 0.1 0.0089 16.3 0.1 1.9 1 0 0 1 1 1 1 BTB/POZ domain Ribosomal_S27e PF01667.17 EFC41547.1 - 4.6e-29 99.9 6.1 5.7e-29 99.6 6.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 DUF3795 PF12675.7 EFC41547.1 - 0.02 15.3 0.8 0.14 12.6 0.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3795) Mu-like_Com PF10122.9 EFC41547.1 - 0.08 12.4 1.5 6.7 6.2 0.5 2.2 2 0 0 2 2 2 0 Mu-like prophage protein Com zf-C2HC5 PF06221.13 EFC41547.1 - 0.73 9.9 6.9 2.7 8.0 3.0 2.5 1 1 2 3 3 3 0 Putative zinc finger motif, C2HC5-type Glyco_transf_34 PF05637.12 EFC41548.1 - 4.9e-16 59.2 8.1 1.7e-14 54.1 8.1 2.1 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 EFC41548.1 - 0.00028 20.5 0.5 0.00037 20.1 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF273 DUF3146 PF11344.8 EFC41548.1 - 0.063 12.9 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3146) LRR_6 PF13516.6 EFC41549.1 - 2e-41 136.5 12.5 4.6e-05 23.2 0.0 9.1 9 0 0 9 9 9 8 Leucine Rich repeat LRR_4 PF12799.7 EFC41549.1 - 3.2e-23 81.4 12.9 0.00024 21.4 0.2 5.8 2 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC41549.1 - 4.9e-20 71.0 7.3 7.8e-06 25.6 0.8 4.9 4 1 2 6 6 6 4 Leucine rich repeat LRR_1 PF00560.33 EFC41549.1 - 3.4e-11 42.1 7.9 3.7 8.5 0.1 8.9 9 2 0 10 10 10 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC41549.1 - 1.3e-06 28.0 0.3 0.0072 15.8 0.1 2.8 1 1 1 2 2 2 2 Leucine-rich repeat ApoB100_C PF12491.8 EFC41549.1 - 2.8e-05 24.0 7.8 2.1 8.4 0.1 6.7 3 3 4 7 7 7 2 Apolipoprotein B100 C terminal PulA_N1 PF17999.1 EFC41549.1 - 0.022 15.5 1.9 17 6.2 0.1 3.5 2 1 1 3 3 3 0 Pullulanase N1-terminal domain DUF4347 PF14252.6 EFC41549.1 - 0.043 13.7 0.2 1e+02 2.7 0.0 4.6 2 2 2 6 6 6 0 Domain of unknown function (DUF4347) Beta_helix PF13229.6 EFC41549.1 - 0.082 12.8 8.9 0.23 11.3 8.9 1.8 1 1 0 1 1 1 0 Right handed beta helix region SO_alpha_A3 PF17806.1 EFC41549.1 - 0.16 12.3 0.2 6.7 7.1 0.0 3.2 2 1 2 4 4 4 0 Sarcosine oxidase A3 domain RCC1 PF00415.18 EFC41550.1 - 8e-36 122.4 0.5 1.6e-10 41.4 0.1 6.7 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC41550.1 - 9.5e-35 117.7 4.2 1.3e-08 34.4 0.3 5.6 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat MFS_1 PF07690.16 EFC41551.1 - 4.2e-23 81.8 26.6 9.4e-14 51.1 6.2 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily UNC-93 PF05978.16 EFC41551.1 - 5.3e-16 58.7 17.7 5.3e-16 58.7 17.7 5.0 4 2 2 6 6 6 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EFC41551.1 - 0.00054 19.0 2.7 0.00054 19.0 2.7 3.6 3 1 1 4 4 4 2 Sugar (and other) transporter Lig_chan PF00060.26 EFC41551.1 - 1.4 8.7 6.0 2.1 8.2 0.1 3.1 4 0 0 4 4 4 0 Ligand-gated ion channel DUF4116 PF13475.6 EFC41552.1 - 1.3e-43 146.5 17.6 1.1e-10 41.1 0.0 9.6 4 3 3 8 8 8 8 Domain of unknown function (DUF4116) DUF3479 PF11965.8 EFC41552.1 - 0.02 15.0 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) Pox_A3L PF05288.11 EFC41552.1 - 0.13 12.3 6.3 9.2 6.3 0.0 4.3 5 0 0 5 5 5 0 Poxvirus A3L Protein EGF_2 PF07974.13 EFC41553.1 - 1.7e-30 105.1 154.5 0.00022 21.5 8.0 11.2 11 0 0 11 11 11 10 EGF-like domain EGF PF00008.27 EFC41553.1 - 2.5e-10 40.5 106.6 0.0082 16.4 4.9 11.7 11 0 0 11 11 11 9 EGF-like domain VIT PF08487.10 EFC41554.1 - 1e-21 77.2 1.4 2.7e-21 75.8 0.2 2.4 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain DUF2135 PF09906.9 EFC41554.1 - 1.8e-08 34.6 0.0 5.2e-08 33.1 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2135) TPR_9 PF13371.6 EFC41554.1 - 0.00026 21.1 0.0 0.00053 20.1 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat VIT_2 PF13757.6 EFC41554.1 - 0.0075 16.1 1.8 0.012 15.4 0.0 2.3 3 0 0 3 3 3 1 Vault protein inter-alpha-trypsin domain Ras PF00071.22 EFC41555.1 - 2.4e-52 176.8 0.0 2.7e-52 176.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41555.1 - 7.2e-20 71.4 0.0 1.4e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41555.1 - 2.2e-08 33.8 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 EFC41555.1 - 0.1 12.3 0.0 3.8 7.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 EFC41556.1 - 2e-49 168.3 0.0 3.2e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC41556.1 - 1.6e-36 122.5 9.4 6.5e-07 29.1 0.0 11.8 12 0 0 12 12 12 8 NHL repeat Pkinase_Tyr PF07714.17 EFC41556.1 - 6.8e-29 100.9 0.0 9.8e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase TMEM154 PF15102.6 EFC41556.1 - 8.9e-05 22.4 1.4 0.00025 21.0 1.4 1.7 1 0 0 1 1 1 1 TMEM154 protein family Kdo PF06293.14 EFC41556.1 - 0.0033 16.8 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC41556.1 - 0.036 12.8 0.0 0.061 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Phytase-like PF13449.6 EFC41556.1 - 0.094 12.6 0.1 34 4.3 0.0 3.6 4 0 0 4 4 4 0 Esterase-like activity of phytase DUF4064 PF13273.6 EFC41556.1 - 0.1 12.9 2.8 0.33 11.3 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF5385 PF17359.2 EFC41556.1 - 0.13 11.8 1.9 0.21 11.1 1.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) APH PF01636.23 EFC41556.1 - 0.18 11.7 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family EGF_2 PF07974.13 EFC41556.1 - 0.29 11.5 15.3 0.68 10.3 15.3 1.7 1 0 0 1 1 1 0 EGF-like domain DUF4330 PF14221.6 EFC41556.1 - 0.32 11.2 3.5 1.4 9.1 0.8 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4330) Shisa PF13908.6 EFC41556.1 - 0.34 11.1 5.6 0.088 13.0 2.2 1.7 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF3377 PF11857.8 EFC41556.1 - 8.4 6.4 6.7 5.7 6.9 3.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) EF-hand_7 PF13499.6 EFC41557.1 - 0.0003 21.2 0.5 0.28 11.7 0.5 2.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EFC41557.1 - 0.00035 20.4 0.0 0.33 10.8 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC41557.1 - 0.036 13.6 0.5 7.2 6.4 0.0 3.7 3 1 1 4 4 4 0 EF hand IP_trans PF02121.18 EFC41558.1 - 0.18 11.3 0.7 0.34 10.4 0.7 1.4 1 0 0 1 1 1 0 Phosphatidylinositol transfer protein Peptidase_S15 PF02129.18 EFC41559.1 - 8e-40 137.1 0.8 7.6e-36 124.1 0.1 2.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EFC41559.1 - 4.8e-34 118.3 0.0 7.3e-34 117.7 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain zf-ZPR1 PF03367.13 EFC41560.1 - 8.2e-109 360.5 0.0 7.8e-55 185.1 0.0 2.2 2 0 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 EFC41560.1 - 0.024 14.7 0.4 3.2 7.8 0.1 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA OrfB_Zn_ribbon PF07282.11 EFC41560.1 - 0.059 13.3 0.3 4.1 7.4 0.0 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DUF2752 PF10825.8 EFC41560.1 - 1.1 9.4 3.0 9 6.4 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) Lar_restr_allev PF14354.6 EFC41560.1 - 1.4 9.3 6.7 5.2 7.5 0.2 2.9 2 1 0 2 2 2 0 Restriction alleviation protein Lar CpXC PF14353.6 EFC41560.1 - 1.9 8.6 4.2 24 5.0 0.2 3.0 2 2 0 2 2 2 0 CpXC protein FHIPEP PF00771.20 EFC41561.1 - 0.25 9.7 3.1 2.6 6.4 0.0 2.1 2 0 0 2 2 2 0 FHIPEP family DUF3347 PF11827.8 EFC41561.1 - 1.2 9.3 11.2 0.32 11.2 6.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3347) RabGAP-TBC PF00566.18 EFC41561.1 - 1.8 8.1 6.8 2.1 7.9 0.1 2.6 2 1 0 2 2 2 0 Rab-GTPase-TBC domain CAC1F_C PF16885.5 EFC41561.1 - 3.2 7.3 7.7 5.8 6.5 7.7 1.4 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Glyco_transf_22 PF03901.17 EFC41562.1 - 1.6e-39 136.3 14.4 2e-39 136.0 14.4 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Pre-PUA PF17832.1 EFC41563.1 - 3.3e-08 34.1 12.4 0.0005 20.7 0.6 2.8 2 1 0 3 3 3 2 Pre-PUA-like domain DUF1947 PF09183.10 EFC41563.1 - 0.0021 18.3 0.3 1.9 8.8 0.1 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF1947) Kin17_mid PF10357.9 EFC41563.1 - 0.04 13.8 2.2 0.044 13.7 0.1 2.1 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein Tox-PLDMTX PF15645.6 EFC41563.1 - 0.045 14.0 0.1 0.098 12.9 0.1 1.6 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold PUA PF01472.20 EFC41563.1 - 0.18 11.8 0.0 5.6 7.0 0.0 2.3 2 0 0 2 2 2 0 PUA domain RNA_pol_Rpo13 PF12136.8 EFC41563.1 - 0.23 11.4 2.9 0.6 10.1 2.9 1.7 1 0 0 1 1 1 0 RNA polymerase Rpo13 subunit HTH domain An_peroxidase PF03098.15 EFC41564.1 - 3.3e-121 405.5 0.0 4e-121 405.2 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase Ank_5 PF13857.6 EFC41566.1 - 0.0001 22.5 0.1 0.0049 17.2 0.1 3.1 2 1 0 2 2 2 1 Ankyrin repeats (many copies) DUF4367 PF14285.6 EFC41566.1 - 1.7 9.1 7.9 1 9.8 2.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4367) MgtE PF01769.16 EFC41567.1 - 2.8e-19 69.7 9.6 2.8e-19 69.7 9.6 1.8 1 1 1 2 2 2 1 Divalent cation transporter Hamartin PF04388.12 EFC41567.1 - 0.062 12.0 0.3 0.079 11.6 0.3 1.1 1 0 0 1 1 1 0 Hamartin protein SPT16 PF08644.11 EFC41568.1 - 8.2e-43 146.2 1.6 8.2e-43 146.2 1.6 2.6 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) Peptidase_M24 PF00557.24 EFC41568.1 - 1.2e-15 57.8 0.0 2.3e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 EFC41568.1 - 5.5e-15 55.6 0.1 1.6e-14 54.0 0.1 1.8 1 0 0 1 1 1 1 Histone chaperone Rttp106-like FACT-Spt16_Nlob PF14826.6 EFC41568.1 - 3.4e-12 46.5 0.4 1.1e-11 44.8 0.4 1.9 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain DUF2200 PF09966.9 EFC41568.1 - 0.088 13.0 0.2 0.088 13.0 0.2 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2200) Imm25 PF15564.6 EFC41568.1 - 0.13 12.2 1.6 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 Immunity protein 25 RNA_pol_N PF01194.17 EFC41569.1 - 4.3e-28 97.4 1.0 7e-28 96.7 1.0 1.4 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 EFC41569.1 - 0.00061 20.0 0.6 0.00075 19.7 0.6 1.2 1 0 0 1 1 1 1 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) ABC_tran PF00005.27 EFC41570.1 - 2.5e-27 96.0 0.0 6e-27 94.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFC41570.1 - 1.4e-12 48.1 4.7 1.9e-10 41.1 0.1 2.7 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFC41570.1 - 0.00074 18.7 48.8 0.016 14.3 48.8 2.5 1 1 0 1 1 1 1 ABC-2 family transporter protein Chitin_synth_1 PF01644.17 EFC41570.1 - 0.0029 17.6 1.5 0.19 11.7 0.2 2.9 3 0 0 3 3 3 1 Chitin synthase SMC_N PF02463.19 EFC41570.1 - 0.0033 16.9 1.8 0.11 11.9 0.0 2.6 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EFC41570.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Scaffolding_pro PF11418.8 EFC41570.1 - 0.12 12.9 0.4 5.3 7.7 0.0 3.0 3 0 0 3 3 3 0 Phi29 scaffolding protein CAP_C PF08603.11 EFC41571.1 - 0.025 14.2 1.4 0.025 14.2 1.4 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) C terminal RRM_1 PF00076.22 EFC41572.1 - 2.8e-23 81.5 0.4 7.5e-13 48.1 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OCRE PF17780.1 EFC41572.1 - 1.4e-15 57.0 15.6 4.6e-15 55.4 15.6 2.0 1 0 0 1 1 1 1 OCRE domain G-patch PF01585.23 EFC41572.1 - 3.2e-15 55.7 1.2 3.2e-15 55.7 1.2 2.8 3 0 0 3 3 3 1 G-patch domain G-patch_2 PF12656.7 EFC41572.1 - 3.2e-05 23.9 0.8 0.00013 21.9 0.8 2.2 1 0 0 1 1 1 1 G-patch domain zf-RanBP PF00641.18 EFC41572.1 - 0.00028 20.1 3.0 0.00055 19.2 3.0 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Nup35_RRM PF05172.13 EFC41572.1 - 0.041 13.9 0.1 11 6.1 0.0 3.1 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif TPR_19 PF14559.6 EFC41573.1 - 2.6e-19 69.5 0.3 0.00027 21.4 0.0 7.0 5 2 1 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC41573.1 - 4.6e-17 62.0 20.9 8.7e-08 32.3 0.5 6.0 3 2 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 EFC41573.1 - 8.3e-11 41.8 0.1 0.87 10.6 0.0 7.4 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC41573.1 - 5.2e-10 39.8 0.0 0.00066 20.3 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC41573.1 - 6.1e-08 32.2 22.7 0.0027 17.7 0.4 8.9 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41573.1 - 6.2e-08 32.1 3.7 0.029 14.4 0.1 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC41573.1 - 9.4e-08 32.2 4.8 0.17 12.6 0.0 6.8 8 1 0 8 8 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41573.1 - 3.2e-06 27.3 8.7 0.011 16.1 0.5 6.9 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC41573.1 - 2.5e-05 24.3 0.0 0.28 11.3 0.0 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat PPR PF01535.20 EFC41573.1 - 0.00043 20.3 5.1 3.7 8.0 0.0 5.0 4 0 0 4 4 4 2 PPR repeat TPR_1 PF00515.28 EFC41573.1 - 0.00058 19.6 5.6 0.014 15.2 0.3 7.5 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41573.1 - 0.0022 18.1 16.5 0.19 12.1 0.3 5.8 7 0 0 7 7 5 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFC41573.1 - 0.0024 17.5 0.1 5.1 6.8 0.0 3.9 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) Fis1_TPR_C PF14853.6 EFC41573.1 - 0.0029 17.6 7.9 2.6 8.2 0.0 5.1 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 EFC41573.1 - 0.0048 16.7 2.0 3 7.8 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFC41573.1 - 0.006 16.6 0.3 0.006 16.6 0.3 3.9 2 2 1 3 3 3 1 Putative TPR-like repeat TPR_4 PF07721.14 EFC41573.1 - 0.0072 16.8 0.0 40 5.2 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 EFC41573.1 - 0.023 14.9 4.3 4 7.7 0.2 3.5 4 0 0 4 4 3 0 PPR repeat family Nucleopor_Nup85 PF07575.13 EFC41575.1 - 3.5e-20 72.1 7.8 5e-19 68.3 7.8 2.1 1 1 0 1 1 1 1 Nup85 Nucleoporin Phage_min_cap2 PF06152.11 EFC41575.1 - 0.0072 15.3 0.1 0.013 14.4 0.1 1.4 1 0 0 1 1 1 1 Phage minor capsid protein 2 TB2_DP1_HVA22 PF03134.19 EFC41576.1 - 8.1e-10 38.5 6.2 8.1e-10 38.5 6.2 1.9 2 0 0 2 2 2 1 TB2/DP1, HVA22 family DUF5104 PF17117.5 EFC41576.1 - 0.043 14.3 0.4 6.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) Ras PF00071.22 EFC41577.1 - 3.8e-57 192.4 0.5 4.7e-57 192.1 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41577.1 - 5.4e-34 117.0 1.4 8.3e-34 116.4 1.4 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41577.1 - 4.2e-15 55.6 0.3 5.5e-15 55.3 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC41577.1 - 7.2e-10 38.6 0.1 9.1e-10 38.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC41577.1 - 4.1e-07 29.7 0.5 3.2e-06 26.8 0.5 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC41577.1 - 6.1e-07 29.0 0.1 9.4e-07 28.4 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC41577.1 - 4.6e-05 23.5 0.3 7.5e-05 22.8 0.3 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC41577.1 - 8.1e-05 22.6 0.0 0.21 11.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_7 PF12775.7 EFC41577.1 - 0.0018 17.8 0.0 0.0035 16.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFC41577.1 - 0.0043 17.3 0.1 0.01 16.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 EFC41577.1 - 0.013 14.9 0.1 0.09 12.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 EFC41577.1 - 0.032 14.0 0.1 0.12 12.2 0.0 1.9 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFC41577.1 - 0.032 13.9 0.3 0.11 12.2 0.2 2.0 1 1 1 2 2 2 0 AAA domain cobW PF02492.19 EFC41577.1 - 0.039 13.5 0.1 0.7 9.5 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IIGP PF05049.13 EFC41577.1 - 0.048 12.7 0.0 0.11 11.5 0.0 1.6 1 1 1 2 2 2 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 EFC41577.1 - 0.065 13.7 1.6 0.26 11.8 1.6 2.0 1 1 0 1 1 1 0 ABC transporter MoeA_N PF03453.17 EFC41577.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.2 1 0 0 1 1 1 0 MoeA N-terminal region (domain I and II) DUF4266 PF14086.6 EFC41577.1 - 0.33 11.9 6.9 1.6 9.7 6.5 2.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4266) NmrA PF05368.13 EFC41578.1 - 2.6e-18 66.4 0.1 4.7e-18 65.6 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC41578.1 - 3.1e-10 40.2 0.0 5e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC41578.1 - 4.8e-06 26.2 0.1 0.00014 21.4 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFC41578.1 - 0.0003 20.1 0.0 0.0005 19.3 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFC41578.1 - 0.00051 19.5 0.0 0.0033 16.9 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC41578.1 - 0.00059 18.9 0.1 0.002 17.2 0.0 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EFC41578.1 - 0.0021 18.0 0.0 0.019 14.9 0.0 2.2 2 0 0 2 2 2 1 KR domain adh_short PF00106.25 EFC41578.1 - 0.0023 17.4 0.0 0.0038 16.7 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase DapB_N PF01113.20 EFC41578.1 - 0.005 17.0 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 EFC41578.1 - 0.011 16.2 0.0 0.041 14.3 0.0 2.0 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFC41578.1 - 0.016 14.4 0.0 0.023 13.8 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TrkA_N PF02254.18 EFC41578.1 - 0.024 14.9 0.0 0.051 13.8 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 EFC41578.1 - 0.029 14.6 0.0 0.14 12.4 0.0 2.1 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain RmlD_sub_bind PF04321.17 EFC41578.1 - 0.034 13.3 0.1 0.63 9.1 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain GFO_IDH_MocA PF01408.22 EFC41578.1 - 0.037 14.9 0.0 0.074 13.9 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold AcylCoA_dehyd_C PF12186.8 EFC41578.1 - 0.083 13.0 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal DUF4252 PF14060.6 EFC41578.1 - 0.19 11.6 1.9 2 8.3 0.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4252) F-box PF00646.33 EFC41579.1 - 0.0006 19.6 0.1 0.003 17.4 0.0 2.2 2 0 0 2 2 2 1 F-box domain LRR_8 PF13855.6 EFC41579.1 - 0.0019 17.9 7.5 0.68 9.8 0.1 5.9 4 3 1 6 6 6 2 Leucine rich repeat F-box-like PF12937.7 EFC41579.1 - 0.0042 17.0 0.6 0.013 15.4 0.1 2.0 2 0 0 2 2 2 1 F-box-like RGS PF00615.19 EFC41580.1 - 7.6e-07 29.4 1.0 1.9e-06 28.1 1.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain CitMHS PF03600.16 EFC41580.1 - 6 6.0 18.2 19 4.3 18.0 1.8 1 1 0 1 1 1 0 Citrate transporter ketoacyl-synt PF00109.26 EFC41581.1 - 2.7e-50 171.3 1.5 4.9e-50 170.5 0.2 2.0 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFC41581.1 - 1.8e-33 115.0 1.3 9.1e-33 112.8 0.3 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 EFC41581.1 - 0.0013 18.2 0.3 0.0025 17.2 0.1 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 EFC41581.1 - 0.048 14.1 0.0 0.17 12.4 0.0 1.9 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension Put_DNA-bind_N PF06971.13 EFC41582.1 - 0.063 13.3 0.1 0.17 11.9 0.1 1.8 1 0 0 1 1 1 0 Putative DNA-binding protein N-terminus Pkinase PF00069.25 EFC41583.1 - 1.1e-74 251.2 0.0 1.9e-74 250.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41583.1 - 8.2e-46 156.4 0.0 1.4e-45 155.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC41583.1 - 2.2e-09 37.1 0.0 7.7e-06 25.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like PB1 PF00564.24 EFC41583.1 - 2.3e-05 24.2 0.3 5.7e-05 23.0 0.3 1.7 1 0 0 1 1 1 1 PB1 domain RIO1 PF01163.22 EFC41583.1 - 0.0066 16.1 0.1 0.022 14.4 0.0 1.7 1 1 0 1 1 1 1 RIO1 family APH PF01636.23 EFC41583.1 - 0.0075 16.2 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EFC41583.1 - 0.008 15.7 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL NUC129 PF08157.11 EFC41583.1 - 0.31 11.4 2.6 0.53 10.7 0.0 2.7 3 0 0 3 3 3 0 NUC129 domain DUF2046 PF09755.9 EFC41584.1 - 4.5e-22 78.6 26.6 5.4e-22 78.4 26.6 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein H4 (DUF2046) bZIP_1 PF00170.21 EFC41584.1 - 0.033 14.3 5.3 0.033 14.3 5.3 3.1 2 1 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 EFC41584.1 - 0.053 13.6 1.8 0.053 13.6 1.8 3.7 2 2 2 4 4 4 0 Basic region leucine zipper Pox_A_type_inc PF04508.12 EFC41584.1 - 0.061 13.2 0.5 0.061 13.2 0.5 2.9 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat DUF4407 PF14362.6 EFC41584.1 - 0.27 10.5 14.3 0.32 10.3 14.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mei5 PF10376.9 EFC41584.1 - 1.5 8.6 30.4 2.6 7.8 30.4 1.5 1 1 0 1 1 1 0 Double-strand recombination repair protein TMPIT PF07851.13 EFC41584.1 - 2.5 7.3 15.5 3.2 6.9 15.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein Ant_C PF05586.11 EFC41584.1 - 2.6 8.7 8.5 1.7 9.3 2.3 2.6 1 1 2 3 3 3 0 Anthrax receptor C-terminus region DivIC PF04977.15 EFC41584.1 - 2.9 7.7 26.2 17 5.2 6.8 3.4 1 1 1 2 2 2 0 Septum formation initiator Latarcin PF10279.9 EFC41585.1 - 0.92 10.0 5.4 0.22 11.9 0.9 2.4 2 1 0 2 2 2 0 Latarcin precursor DUF1664 PF07889.12 EFC41585.1 - 1.6 8.8 22.8 0.19 11.8 1.4 4.3 2 1 2 5 5 5 0 Protein of unknown function (DUF1664) Phage_lysis PF03245.13 EFC41585.1 - 5.5 7.1 10.2 2.4 8.3 1.0 3.7 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein GAS PF13851.6 EFC41586.1 - 0.0043 16.4 14.7 0.0067 15.8 14.7 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 EFC41586.1 - 0.0051 16.8 10.4 0.0083 16.1 10.4 1.3 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Armet PF10208.9 EFC41586.1 - 0.0063 16.5 0.9 0.01 15.8 0.9 1.3 1 0 0 1 1 1 1 Degradation arginine-rich protein for mis-folding Tropomyosin_1 PF12718.7 EFC41586.1 - 0.05 13.8 18.3 0.6 10.3 15.9 2.1 1 1 1 2 2 2 0 Tropomyosin like COMMD1_N PF17221.3 EFC41586.1 - 0.051 13.9 4.3 0.13 12.6 4.3 1.7 1 1 0 1 1 1 0 COMMD1 N-terminal domain DivIC PF04977.15 EFC41586.1 - 0.067 13.0 15.9 0.45 10.3 2.7 2.9 1 1 2 3 3 3 0 Septum formation initiator bZIP_2 PF07716.15 EFC41586.1 - 0.12 12.5 14.5 1.6 8.9 1.8 2.5 2 0 0 2 2 2 0 Basic region leucine zipper Ax_dynein_light PF10211.9 EFC41586.1 - 0.16 11.9 14.1 0.29 11.1 14.1 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain DUF4200 PF13863.6 EFC41586.1 - 0.2 12.0 15.2 0.35 11.3 15.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) HALZ PF02183.18 EFC41586.1 - 0.22 11.8 11.7 0.14 12.4 0.8 2.7 2 1 1 3 3 3 0 Homeobox associated leucine zipper Macoilin PF09726.9 EFC41586.1 - 0.39 9.2 26.1 0.53 8.8 26.1 1.3 1 0 0 1 1 1 0 Macoilin family Rootletin PF15035.6 EFC41586.1 - 0.6 10.1 23.3 1.8 8.5 9.1 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion AI-2E_transport PF01594.16 EFC41586.1 - 1 8.4 2.8 2.1 7.4 2.8 1.5 1 0 0 1 1 1 0 AI-2E family transporter DUF745 PF05335.13 EFC41586.1 - 2.6 7.8 9.4 4.3 7.0 9.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF3450 PF11932.8 EFC41586.1 - 2.8 7.2 14.7 4 6.7 14.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Chordopox_G3 PF06129.12 EFC41586.1 - 4.2 8.1 18.0 1.1 10.0 5.0 2.8 2 1 1 3 3 3 0 Chordopoxvirus G3 protein ZapB PF06005.12 EFC41586.1 - 9.9 6.7 19.2 1.8e+04 -4.5 19.2 2.6 1 1 0 1 1 0 0 Cell division protein ZapB Pkinase PF00069.25 EFC41587.1 - 3.7e-06 26.5 0.0 4.9e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RelB PF04221.12 EFC41587.1 - 0.16 12.0 0.3 0.26 11.3 0.1 1.4 2 0 0 2 2 2 0 RelB antitoxin Lactamase_B PF00753.27 EFC41588.1 - 1.8e-07 31.3 0.0 3.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC41588.1 - 0.0014 18.2 0.0 0.0024 17.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC41588.1 - 0.03 14.2 0.0 0.17 11.8 0.0 2.0 1 1 0 1 1 1 0 Beta-lactamase superfamily domain FapA PF03961.13 EFC41588.1 - 0.12 11.0 1.2 0.17 10.5 1.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A UQ_con PF00179.26 EFC41589.1 - 9.4e-21 73.9 0.3 1.5e-20 73.2 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme ABC_transp_aux PF09822.9 EFC41589.1 - 0.012 15.2 1.3 0.019 14.5 0.8 1.5 2 0 0 2 2 2 0 ABC-type uncharacterized transport system Med15 PF09606.10 EFC41589.1 - 0.018 13.7 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal RWD PF05773.22 EFC41589.1 - 0.074 13.3 0.6 0.21 11.9 0.0 1.9 1 1 1 2 2 2 0 RWD domain Brix PF04427.18 EFC41590.1 - 1.1e-27 97.4 3.3 1.6e-27 96.8 3.3 1.2 1 0 0 1 1 1 1 Brix domain HTH_Tnp_Tc5 PF03221.16 EFC41590.1 - 0.03 14.3 0.2 0.16 12.1 0.0 2.1 2 0 0 2 2 2 0 Tc5 transposase DNA-binding domain PIN_5 PF08745.11 EFC41590.1 - 0.049 13.0 0.1 1.3 8.4 0.2 2.2 2 0 0 2 2 2 0 PINc domain ribonuclease HhH-GPD PF00730.25 EFC41591.1 - 1.5e-22 80.1 0.0 2.6e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 EFC41591.1 - 9e-09 34.8 0.0 2.2e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif RHH_8 PF17723.1 EFC41591.1 - 0.016 15.4 0.1 5.8 7.1 0.0 2.3 2 0 0 2 2 2 0 Ribbon-Helix-Helix transcriptional regulator family HTH_Tnp_ISL3 PF13542.6 EFC41591.1 - 0.071 12.5 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HHH_5 PF14520.6 EFC41591.1 - 0.17 12.5 0.0 1.2 9.8 0.0 2.2 2 0 0 2 2 2 0 Helix-hairpin-helix domain RTP1_C1 PF10363.9 EFC41592.1 - 9.4e-33 112.7 0.7 5.5e-32 110.3 0.4 2.6 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 EFC41592.1 - 0.00058 20.2 0.1 0.09 13.2 0.0 3.9 4 1 0 4 4 4 1 HEAT repeats TAF6_C PF07571.13 EFC41592.1 - 0.02 15.2 0.1 1.2 9.6 0.0 3.4 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain Vac14_Fab1_bd PF12755.7 EFC41592.1 - 0.074 13.7 5.6 1.3 9.7 0.1 4.7 3 1 2 5 5 5 0 Vacuolar 14 Fab1-binding region Atx10homo_assoc PF09759.9 EFC41592.1 - 0.52 10.4 4.5 8 6.6 0.3 3.1 2 2 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain Plasmid_parti PF01672.16 EFC41592.1 - 8.1 7.2 8.1 1.1 10.0 0.1 3.4 4 0 0 4 4 4 0 Putative plasmid partition protein Tim44 PF04280.15 EFC41593.1 - 4e-24 85.4 5.2 2.6e-23 82.7 0.1 2.6 2 0 0 2 2 2 1 Tim44-like domain RuvB_C PF05491.13 EFC41593.1 - 0.019 14.8 0.1 0.094 12.6 0.0 2.2 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain DUF3276 PF11680.8 EFC41593.1 - 0.62 10.2 8.4 15 5.7 4.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3276) DNA_primase_lrg PF04104.14 EFC41594.1 - 4.2e-75 252.6 0.9 7.3e-75 251.8 0.9 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit POTRA PF07244.15 EFC41594.1 - 0.013 16.1 0.0 0.4 11.3 0.0 2.5 2 0 0 2 2 2 0 Surface antigen variable number repeat LRR_4 PF12799.7 EFC41595.1 - 1.4e-09 38.0 19.4 2.2e-07 31.1 1.1 4.0 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC41595.1 - 3.1e-07 30.0 7.9 2e-06 27.4 2.2 2.8 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 EFC41595.1 - 0.00017 21.7 5.1 1.7 9.5 0.0 4.7 4 0 0 4 4 3 2 Leucine Rich Repeat EF-hand_1 PF00036.32 EFC41595.1 - 0.00031 20.1 0.3 0.0079 15.7 0.1 3.1 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EFC41595.1 - 0.00055 20.3 0.2 0.0034 17.8 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC41595.1 - 0.00074 19.2 1.1 0.044 13.7 0.2 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 EFC41595.1 - 0.012 15.1 0.2 0.032 13.7 0.2 1.8 1 0 0 1 1 1 0 EF hand EF-hand_8 PF13833.6 EFC41595.1 - 0.065 13.1 0.0 0.34 10.8 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain pair CCDC-167 PF15188.6 EFC41595.1 - 0.065 13.6 9.4 0.13 12.6 3.8 3.6 4 1 0 4 4 2 0 Coiled-coil domain-containing protein 167 SPARC_Ca_bdg PF10591.9 EFC41595.1 - 0.4 11.0 3.9 2.2 8.6 0.0 3.4 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region T3SS_needle_F PF09392.10 EFC41595.1 - 1.1 9.5 7.3 0.14 12.4 0.8 3.0 3 0 0 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DIT1_PvcA PF05141.12 EFC41595.1 - 9.1 5.7 14.2 0.03 13.8 0.8 3.0 3 1 1 4 4 4 0 Pyoverdine/dityrosine biosynthesis protein DUF4879 PF16219.5 EFC41597.1 - 0.25 11.6 4.9 0.22 11.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4879) zf-RING_2 PF13639.6 EFC41598.1 - 1.7e-13 50.7 11.6 2.5e-13 50.1 11.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFC41598.1 - 5e-08 33.1 13.6 1.2e-07 31.9 13.6 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFC41598.1 - 2.7e-07 30.6 3.6 4.9e-07 29.7 3.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 EFC41598.1 - 1.5e-06 28.0 12.0 2.5e-06 27.2 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC41598.1 - 4.9e-06 26.3 9.2 0.00048 19.9 4.7 2.2 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFC41598.1 - 5.9e-06 26.1 12.5 9.4e-06 25.4 12.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC41598.1 - 1.4e-05 24.7 7.4 2.7e-05 23.8 7.4 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 EFC41598.1 - 0.00014 21.7 12.0 0.00022 21.1 12.0 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFC41598.1 - 0.00025 21.0 5.8 0.00025 21.0 5.8 1.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFC41598.1 - 0.0003 20.6 9.4 0.001 18.9 9.5 1.7 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Ribosomal_S17_N PF16205.5 EFC41598.1 - 0.0074 16.6 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal zf-RING-like PF08746.11 EFC41598.1 - 0.012 15.9 10.1 0.02 15.2 10.1 1.4 1 0 0 1 1 1 0 RING-like domain UBZ_FAAP20 PF15750.5 EFC41598.1 - 0.022 14.7 0.8 6.7 6.8 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Zn_ribbon_17 PF17120.5 EFC41598.1 - 0.041 13.5 9.2 0.083 12.5 9.2 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 EFC41598.1 - 0.045 13.7 9.3 0.21 11.6 4.8 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 EFC41598.1 - 0.049 13.4 10.2 0.095 12.5 10.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn-C2H2_12 PF18112.1 EFC41598.1 - 0.068 13.6 0.3 0.068 13.6 0.3 3.0 3 0 0 3 3 2 0 Autophagy receptor zinc finger-C2H2 domain FANCL_C PF11793.8 EFC41598.1 - 0.1 12.8 10.6 1.5 9.1 10.6 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zinc_ribbon_16 PF17034.5 EFC41598.1 - 0.22 11.8 6.9 0.28 11.4 4.5 2.0 1 1 1 2 2 2 0 Zinc-ribbon like family PHD PF00628.29 EFC41598.1 - 0.26 11.2 11.1 0.59 10.1 11.1 1.7 1 1 0 1 1 1 0 PHD-finger Cript PF10235.9 EFC41598.1 - 0.27 11.8 3.9 3.8 8.2 0.6 2.3 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT DUF5318 PF17249.2 EFC41598.1 - 0.36 10.6 2.7 1.8 8.3 0.2 2.2 1 1 0 2 2 2 0 Family of unknown function (DUF5318) zf-P11 PF03854.14 EFC41598.1 - 0.91 9.2 10.2 4.7 7.0 10.2 2.0 1 1 0 1 1 1 0 P-11 zinc finger tRNA-synt_1g PF09334.11 EFC41598.1 - 1 8.0 6.5 1 8.0 1.9 2.1 1 1 1 2 2 2 0 tRNA synthetases class I (M) RINGv PF12906.7 EFC41598.1 - 1.1 9.4 10.1 3.4 7.9 10.2 1.8 1 1 1 2 2 2 0 RING-variant domain zf-C3H2C3 PF17122.5 EFC41598.1 - 1.7 8.8 9.2 2.8 8.1 4.0 2.7 2 1 0 2 2 2 0 Zinc-finger YdjO PF14169.6 EFC41598.1 - 1.8 8.3 8.0 20 5.0 4.4 2.5 1 1 1 2 2 2 0 Cold-inducible protein YdjO RPAP2_Rtr1 PF04181.13 EFC41599.1 - 4.3e-11 43.0 0.6 4.3e-11 43.0 0.6 2.2 3 0 0 3 3 3 1 Rtr1/RPAP2 family Cyclin_C_2 PF16899.5 EFC41600.1 - 1e-10 41.9 3.2 1.9e-10 41.1 0.3 2.7 2 2 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 EFC41600.1 - 1.4e-09 37.8 1.8 1.4e-09 37.8 1.8 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain Lactamase_B_6 PF16661.5 EFC41600.1 - 0.011 15.2 0.1 0.023 14.1 0.1 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Peptidase_Prp PF04327.12 EFC41600.1 - 0.064 13.5 2.4 0.071 13.4 0.8 1.9 2 0 0 2 2 2 0 Cysteine protease Prp PAS PF00989.25 EFC41601.1 - 2.4e-12 46.9 0.0 1.1e-11 44.7 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_9 PF13426.7 EFC41601.1 - 3e-08 33.8 0.0 1.6e-07 31.5 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS_8 PF13188.7 EFC41601.1 - 0.00013 21.9 0.0 0.0003 20.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC41601.1 - 0.00025 21.2 0.0 0.00048 20.4 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_7 PF12860.7 EFC41601.1 - 0.1 12.7 0.0 0.4 10.8 0.0 2.1 1 0 0 1 1 1 0 PAS fold Syntaxin-6_N PF09177.11 EFC41601.1 - 0.95 10.1 8.9 3.8 8.1 0.4 3.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal E7 PF00527.18 EFC41602.1 - 0.95 9.7 3.8 3.5 7.9 2.7 2.3 2 1 0 2 2 2 0 E7 protein, Early protein XhlA PF10779.9 EFC41602.1 - 8.2 6.7 18.5 0.46 10.7 5.6 3.0 3 0 0 3 3 3 0 Haemolysin XhlA DUF4364 PF14277.6 EFC41603.1 - 0.015 15.0 0.4 0.027 14.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Biotin_lipoyl PF00364.22 EFC41604.1 - 3e-08 33.4 0.0 6.8e-08 32.2 0.0 1.6 1 1 1 2 2 2 2 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFC41604.1 - 0.00065 19.5 0.1 0.14 12.0 0.2 2.3 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-synt_ab_Xtn PF16886.5 EFC41604.1 - 0.085 12.7 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension SecA_PP_bind PF01043.20 EFC41605.1 - 0.038 14.6 0.3 0.048 14.3 0.3 1.3 1 1 0 1 1 1 0 SecA preprotein cross-linking domain HAP2-GCS1 PF10699.9 EFC41606.1 - 7.2e-21 73.9 0.0 1.6e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Male gamete fusion factor Zip PF02535.22 EFC41606.1 - 0.0013 18.0 0.1 0.002 17.4 0.1 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4834 PF16118.5 EFC41606.1 - 0.0013 19.6 0.1 0.0039 18.1 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) FAM176 PF14851.6 EFC41606.1 - 0.1 12.3 2.1 0.2 11.3 2.1 1.4 1 0 0 1 1 1 0 FAM176 family G0-G1_switch_2 PF15103.6 EFC41606.1 - 2.2 8.7 8.0 7.7 7.0 8.0 1.9 1 0 0 1 1 1 0 G0/G1 switch protein 2 RNA_pol_Rpc4 PF05132.14 EFC41606.1 - 4.7 7.6 9.0 10 6.5 9.0 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 AIF_C PF14721.6 EFC41606.1 - 5.2 7.4 9.2 13 6.1 9.2 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RP-C_C PF11800.8 EFC41606.1 - 5.3 7.1 6.4 10 6.1 6.4 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF2828 PF11443.8 EFC41606.1 - 6.2 4.8 13.8 8.9 4.3 13.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SAM_2 PF07647.17 EFC41607.1 - 0.0012 18.9 0.0 0.0044 17.1 0.0 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) F-box-like PF12937.7 EFC41608.1 - 1.4e-07 31.3 0.1 3.1e-07 30.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC41608.1 - 0.0031 17.3 0.0 0.0099 15.7 0.0 1.9 1 0 0 1 1 1 1 F-box domain Ank_4 PF13637.6 EFC41608.1 - 0.016 15.8 0.0 1.1 10.0 0.0 3.7 3 1 0 3 3 3 0 Ankyrin repeats (many copies) OCD_Mu_crystall PF02423.15 EFC41609.1 - 3.1e-38 131.5 0.0 1.9e-20 73.1 0.0 2.1 1 1 1 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 EFC41609.1 - 0.00044 20.3 0.1 1.3 9.1 0.0 2.5 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase ALO PF04030.14 EFC41609.1 - 0.073 12.9 0.2 0.12 12.1 0.2 1.2 1 0 0 1 1 1 0 D-arabinono-1,4-lactone oxidase DUF190 PF02641.15 EFC41609.1 - 0.08 13.3 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 DUF4476 PF14771.6 EFC41610.1 - 8.7e-24 83.7 5.2 7.7e-16 58.2 0.6 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) PAT1 PF09770.9 EFC41610.1 - 1.2 7.3 30.3 1.8 6.7 30.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LSM PF01423.22 EFC41611.1 - 8.7e-14 51.0 0.1 1.1e-13 50.6 0.1 1.2 1 0 0 1 1 1 1 LSM domain Kelch_4 PF13418.6 EFC41612.1 - 4.1e-45 151.6 27.4 3e-07 30.3 0.1 10.7 10 0 0 10 10 10 8 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC41612.1 - 1.9e-44 149.0 22.8 4.4e-06 26.5 0.4 10.2 10 0 0 10 10 10 9 Kelch motif Kelch_6 PF13964.6 EFC41612.1 - 5.9e-37 124.8 36.3 0.00011 22.3 0.2 10.6 11 0 0 11 11 11 8 Kelch motif Kelch_3 PF13415.6 EFC41612.1 - 3.8e-35 119.5 24.2 2.3e-05 24.6 0.0 12.3 12 0 0 12 12 12 7 Galactose oxidase, central domain ANF_receptor PF01094.28 EFC41612.1 - 5.2e-33 114.6 4.3 1.1e-32 113.6 3.6 1.8 2 0 0 2 2 2 1 Receptor family ligand binding region Kelch_1 PF01344.25 EFC41612.1 - 3.1e-25 87.5 22.2 5.4e-05 22.7 0.0 9.9 10 1 0 10 10 10 8 Kelch motif Kelch_2 PF07646.15 EFC41612.1 - 8.4e-20 69.9 18.0 0.002 18.0 0.1 8.9 8 0 0 8 8 8 6 Kelch motif Peripla_BP_6 PF13458.6 EFC41612.1 - 2e-12 47.4 0.1 3.9e-12 46.5 0.1 1.3 1 0 0 1 1 1 1 Periplasmic binding protein PX PF00787.24 EFC41612.1 - 7.4e-07 29.1 0.2 2.9e-06 27.2 0.2 2.1 1 0 0 1 1 1 1 PX domain Ephrin_rec_like PF07699.13 EFC41612.1 - 5.6e-05 22.8 26.2 0.0039 16.9 5.7 3.4 1 1 2 3 3 3 2 Putative ephrin-receptor like NCD3G PF07562.14 EFC41612.1 - 0.12 12.3 12.4 0.5 10.4 0.5 3.3 2 1 1 3 3 3 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 EFC41612.1 - 4.6 7.7 18.6 2.2 8.8 1.6 3.6 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region ERG4_ERG24 PF01222.17 EFC41613.1 - 1.1e-81 274.8 21.0 1.4e-81 274.5 21.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFC41613.1 - 2.2e-11 43.7 0.8 2.2e-11 43.7 0.8 2.3 3 1 0 3 3 3 1 Protein of unknown function (DUF1295) ICMT PF04140.14 EFC41613.1 - 0.00022 21.6 0.3 0.00077 19.8 0.0 2.1 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFC41613.1 - 0.00062 20.1 0.1 0.00062 20.1 0.1 3.1 3 1 0 3 3 3 1 Phospholipid methyltransferase tRNA-synt_1 PF00133.22 EFC41616.1 - 2.9e-205 683.1 4.0 3.3e-204 679.6 4.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFC41616.1 - 2.4e-44 151.0 0.9 4.6e-44 150.0 0.2 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFC41616.1 - 6.6e-16 58.0 2.9 8.9e-09 34.6 0.3 4.2 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFC41616.1 - 3.7e-07 29.8 0.0 2.3e-05 24.0 0.0 2.6 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EFC41616.1 - 2.1e-05 24.1 0.0 0.034 13.5 0.0 2.7 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Val_tRNA-synt_C PF10458.9 EFC41616.1 - 0.041 14.2 8.3 0.14 12.4 7.6 2.4 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1c PF00749.21 EFC41616.1 - 0.44 9.4 6.2 0.98 8.3 0.1 3.3 3 0 0 3 3 3 0 tRNA synthetases class I (E and Q), catalytic domain COX17 PF05051.13 EFC41617.1 - 1.1e-17 64.1 10.9 3e-17 62.7 3.3 2.1 2 0 0 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) CHCH PF06747.13 EFC41617.1 - 3.3e-05 23.9 3.5 0.02 15.0 1.2 2.3 2 0 0 2 2 2 2 CHCH domain JmjC PF02373.22 EFC41618.1 - 4.7e-37 126.9 0.2 4.7e-37 126.9 0.2 2.2 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 EFC41618.1 - 1.5e-11 44.1 0.9 4.2e-11 42.6 0.9 1.9 1 0 0 1 1 1 1 jmjN domain BRF1 PF07741.13 EFC41618.1 - 0.033 14.5 4.8 0.062 13.6 4.8 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain AP3D1 PF06375.11 EFC41618.1 - 0.12 12.6 6.8 0.21 11.8 6.8 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Coilin_N PF15862.5 EFC41618.1 - 0.29 10.9 10.5 0.26 11.1 9.2 1.5 2 0 0 2 2 2 0 Coilin N-terminus CPSF100_C PF13299.6 EFC41618.1 - 1.3 9.2 5.4 2 8.6 5.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RCC1 PF00415.18 EFC41619.1 - 0.0074 16.9 0.2 0.092 13.4 0.0 2.5 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Ribosomal_L34e PF01199.18 EFC41619.1 - 0.14 12.5 0.1 0.39 11.0 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L34e RhoGAP PF00620.27 EFC41620.1 - 3.3e-29 101.7 0.8 7.1e-29 100.6 0.8 1.6 1 0 0 1 1 1 1 RhoGAP domain C2 PF00168.30 EFC41620.1 - 1.3e-10 41.4 0.1 6.1e-06 26.5 0.1 2.9 2 0 0 2 2 2 2 C2 domain GH97_C PF14509.6 EFC41621.1 - 0.025 14.8 0.5 5.7 7.2 0.0 2.4 1 1 1 2 2 2 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation MJ1316 PF04457.12 EFC41622.1 - 4.7e-08 33.7 0.0 1.3e-07 32.2 0.0 1.8 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain PNISR PF15996.5 EFC41622.1 - 1.1 9.5 11.2 0.15 12.3 7.4 1.4 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR SNF2_N PF00176.23 EFC41624.1 - 3.6e-66 223.3 0.2 6.5e-66 222.4 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC41624.1 - 3.5e-22 78.8 0.1 9.8e-21 74.2 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC41624.1 - 8.3e-11 42.2 0.0 8.3e-11 42.2 0.0 4.0 3 2 1 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFC41624.1 - 5.4e-05 23.0 0.1 0.00021 21.1 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EFC41624.1 - 0.003 16.8 0.0 0.003 16.8 0.0 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DUF3385 PF11865.8 EFC41624.1 - 0.1 12.5 0.3 2.2 8.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) Spore_Cse60 PF10957.8 EFC41624.1 - 0.2 11.7 2.7 0.83 9.7 2.7 2.1 1 0 0 1 1 1 0 Sporulation protein Cse60 PI3K_1B_p101 PF10486.9 EFC41624.1 - 0.97 7.1 13.4 1.6 6.4 13.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit COG4 PF08318.12 EFC41624.1 - 1.3 8.0 11.1 0.084 11.9 5.6 1.7 2 0 0 2 2 2 0 COG4 transport protein RWP-RK PF02042.15 EFC41625.1 - 1e-10 41.4 0.1 2.2e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 RWP-RK domain HTH_8 PF02954.19 EFC41625.1 - 0.0028 17.4 0.0 0.023 14.5 0.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family Sigma70_r4_2 PF08281.12 EFC41625.1 - 0.0052 16.4 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 EFC41625.1 - 0.0085 15.5 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_17 PF12728.7 EFC41625.1 - 0.024 14.8 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 EFC41625.1 - 0.075 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF3853 PF12964.7 EFC41625.1 - 0.1 12.8 0.0 0.38 11.0 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) MerR PF00376.23 EFC41625.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 MerR family regulatory protein HTH_3 PF01381.22 EFC41625.1 - 0.14 12.3 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix CXCXC PF03128.14 EFC41625.1 - 3.3 8.4 4.7 36 5.1 0.2 3.1 3 0 0 3 3 3 0 CXCXC repeat Copine PF07002.16 EFC41626.1 - 4.1e-70 235.6 0.1 5.5e-70 235.2 0.1 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFC41626.1 - 1.3e-14 54.3 0.1 1.1e-06 28.8 0.0 2.4 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFC41626.1 - 1.1e-05 25.6 0.1 0.00011 22.4 0.0 2.1 1 1 1 2 2 2 1 vWA found in TerF C terminus VWA_3 PF13768.6 EFC41626.1 - 0.025 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain NT-C2 PF10358.9 EFC41626.1 - 0.074 12.8 0.9 0.52 10.0 0.2 2.2 2 0 0 2 2 2 0 N-terminal C2 in EEIG1 and EHBP1 proteins Guanylate_cyc PF00211.20 EFC41627.1 - 2.5e-26 92.4 0.8 4.1e-26 91.7 0.8 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain BLUF PF04940.12 EFC41627.1 - 3.8e-23 81.4 0.3 1.3e-22 79.8 0.1 2.0 2 0 0 2 2 2 1 Sensors of blue-light using FAD DUF5039 PF16442.5 EFC41627.1 - 0.094 12.2 0.0 0.38 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5039) BLUF PF04940.12 EFC41628.1 - 1.4e-24 86.0 0.5 3.4e-24 84.8 0.2 1.8 2 0 0 2 2 2 1 Sensors of blue-light using FAD Guanylate_cyc PF00211.20 EFC41628.1 - 8.6e-23 80.9 1.0 1.2e-22 80.4 1.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PALB2_WD40 PF16756.5 EFC41628.1 - 0.032 13.2 0.1 0.051 12.5 0.1 1.2 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain U83 PF17465.2 EFC41628.1 - 0.042 14.0 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 Chemokine-like protein, HHV-6 U83 gene product GCH_III PF05165.12 EFC41628.1 - 0.14 11.4 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase III HXXEE PF13787.6 EFC41629.1 - 7.2e-09 36.4 2.8 7.3e-09 36.4 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function with HXXEE motif CbiG_mid PF11761.8 EFC41629.1 - 0.15 12.2 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis central region Exo_endo_phos PF03372.23 EFC41630.1 - 1.2e-12 47.8 0.0 2e-12 47.1 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFC41630.1 - 0.015 15.1 0.1 0.24 11.2 0.0 2.4 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase Phage_int_SAM_5 PF13102.6 EFC41630.1 - 2.5 8.5 6.0 14 6.1 0.2 3.0 2 1 0 3 3 3 0 Phage integrase SAM-like domain EGF_2 PF07974.13 EFC41631.1 - 1.9e-29 101.7 368.8 0.0023 18.2 15.8 18.3 18 0 0 18 18 18 17 EGF-like domain Metallophos PF00149.28 EFC41632.1 - 0.00045 20.8 0.0 0.00055 20.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC41632.1 - 0.12 12.5 0.0 0.23 11.7 0.0 1.5 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain CFTR_R PF14396.6 EFC41633.1 - 0.14 11.7 0.0 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain LRR_11 PF18831.1 EFC41634.1 - 0.094 12.3 0.7 0.19 11.3 0.3 1.7 2 0 0 2 2 2 0 Leucine-rich repeat Rootletin PF15035.6 EFC41637.1 - 0.037 14.1 9.0 0.088 12.8 9.0 1.6 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion FPP PF05911.11 EFC41637.1 - 0.19 9.9 11.9 0.37 8.9 11.9 1.4 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil RMI1_C PF16099.5 EFC41638.1 - 0.046 13.6 0.9 0.13 12.1 0.9 1.8 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold Aldo_ket_red PF00248.21 EFC41639.1 - 2.1e-06 27.2 0.4 3e-06 26.6 0.4 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Spectrin_like PF18373.1 EFC41639.1 - 0.098 12.7 2.1 0.53 10.4 2.1 2.2 1 1 0 1 1 1 0 Spectrin like domain Cullin_binding PF03556.15 EFC41640.1 - 3.8e-28 98.3 4.8 3.8e-28 98.3 4.8 2.1 2 1 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 EFC41640.1 - 9.8e-12 44.5 0.0 1.7e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain Cloacin_immun PF03513.14 EFC41640.1 - 0.067 13.5 0.4 0.067 13.5 0.4 2.5 2 1 1 3 3 3 0 Cloacin immunity protein Rtt106_N PF18215.1 EFC41640.1 - 0.12 12.1 0.1 0.23 11.2 0.1 1.4 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain DUF1479 PF07350.12 EFC41641.1 - 7e-08 31.7 2.3 0.00042 19.2 0.2 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 EFC41641.1 - 2.6e-05 24.6 0.0 0.015 15.5 0.0 2.4 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Il2rg PF15874.5 EFC41641.1 - 0.026 14.8 0.1 8.9 6.6 0.0 2.7 2 0 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain PARP PF00644.20 EFC41642.1 - 2.5e-15 56.6 1.3 5.4e-14 52.2 1.3 2.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Cwf_Cwc_15 PF04889.12 EFC41642.1 - 0.0053 16.5 9.8 0.0097 15.7 9.8 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein PARP PF00644.20 EFC41643.1 - 3e-11 43.3 0.0 9.5e-11 41.6 0.0 1.8 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 EFC41643.1 - 0.00069 19.4 0.0 0.0011 18.8 0.0 1.3 1 0 0 1 1 1 1 Exotoxin A catalytic zf-C3H1 PF10650.9 EFC41643.1 - 0.0015 18.2 20.3 0.066 13.0 0.4 3.7 3 1 1 4 4 4 3 Putative zinc-finger domain ART-PolyVal PF18760.1 EFC41643.1 - 0.015 16.3 0.1 0.027 15.5 0.1 1.4 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins zf-CCHH PF10283.9 EFC41644.1 - 2.1e-06 27.6 18.3 0.00037 20.4 4.4 3.0 2 0 0 2 2 2 2 PBZ domain YidD PF01809.18 EFC41644.1 - 0.24 11.3 4.7 0.81 9.6 1.1 2.8 1 1 1 2 2 2 0 Putative membrane protein insertion efficiency factor zf-CCCH PF00642.24 EFC41644.1 - 0.39 10.7 4.8 9 6.3 0.5 2.9 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TPR_2 PF07719.17 EFC41644.1 - 2.3 8.6 4.6 4.8 7.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat BTB PF00651.31 EFC41645.1 - 1.7e-16 60.4 0.0 3.1e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Gly_rich PF12810.7 EFC41645.1 - 4.3e-15 56.3 52.6 5.9e-15 55.9 52.6 1.1 1 0 0 1 1 1 1 Glycine rich protein BACK PF07707.15 EFC41645.1 - 2e-14 53.5 1.0 4.9e-14 52.3 0.4 1.8 2 0 0 2 2 2 1 BTB And C-terminal Kelch Motile_Sperm PF00635.26 EFC41646.1 - 2e-07 30.8 0.4 2e-07 30.8 0.4 2.2 2 1 0 2 2 2 1 MSP (Major sperm protein) domain Autophagy_N PF03986.13 EFC41647.1 - 1.8e-41 141.3 0.2 2.9e-41 140.6 0.2 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 EFC41647.1 - 2.7e-21 75.9 0.1 5.1e-21 75.0 0.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 EFC41647.1 - 3e-15 55.4 3.8 5.4e-15 54.6 3.8 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal SHOCT PF09851.9 EFC41647.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 Short C-terminal domain NYN PF01936.18 EFC41648.1 - 5e-16 59.5 0.1 1.5e-15 58.0 0.0 1.8 2 0 0 2 2 2 1 NYN domain DUF3858 PF12970.7 EFC41648.1 - 0.045 13.8 2.7 0.67 10.0 0.2 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3858) PIN7 PF18475.1 EFC41648.1 - 0.091 13.4 0.0 0.25 12.0 0.0 1.9 1 0 0 1 1 1 0 PIN domain EAP30 PF04157.16 EFC41649.1 - 3e-40 138.0 1.7 4.4e-40 137.5 1.7 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 EFC41649.1 - 1.6e-05 25.0 0.1 4.4e-05 23.6 0.1 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 EFC41649.1 - 5.4e-05 23.1 1.9 9.9e-05 22.2 0.8 2.0 2 0 0 2 2 2 1 GRAM domain DUF812 PF05667.11 EFC41649.1 - 0.012 14.5 9.7 0.016 14.1 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MA3 PF02847.17 EFC41649.1 - 0.014 15.4 1.0 6.9 6.7 0.0 2.6 2 0 0 2 2 2 0 MA3 domain RPW8 PF05659.11 EFC41649.1 - 0.02 14.6 2.3 0.04 13.6 1.0 1.9 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF2489 PF10675.9 EFC41649.1 - 0.033 14.1 4.9 0.072 13.0 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) EnY2 PF10163.9 EFC41649.1 - 0.23 11.9 5.1 2 8.9 5.1 2.4 1 1 0 1 1 1 0 Transcription factor e(y)2 DUF648 PF04890.13 EFC41649.1 - 0.48 10.1 7.3 0.15 11.8 3.4 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF648) Ribosomal_S25 PF03297.15 EFC41649.1 - 0.53 10.5 0.0 0.53 10.5 0.0 3.3 4 0 0 4 4 4 0 S25 ribosomal protein Atg14 PF10186.9 EFC41649.1 - 0.9 8.6 6.2 1.5 7.9 6.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CorA PF01544.18 EFC41649.1 - 2.9 7.1 7.7 11 5.3 6.7 2.2 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4665 PF15679.5 EFC41649.1 - 5.4 7.7 12.6 2 9.1 8.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) adh_short_C2 PF13561.6 EFC41650.1 - 5.7e-58 196.2 6.0 6.5e-58 196.1 6.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC41650.1 - 4.1e-50 170.0 7.3 5.3e-50 169.6 7.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC41650.1 - 1.6e-14 54.2 2.6 2.1e-14 53.9 2.6 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC41650.1 - 0.00028 20.4 2.3 0.00059 19.4 2.3 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 EFC41650.1 - 0.0015 18.8 1.8 0.0023 18.2 1.4 1.4 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EFC41650.1 - 0.0057 15.8 2.6 0.0062 15.7 1.8 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EFC41650.1 - 0.0068 16.5 0.3 0.012 15.7 0.3 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Transcrip_reg PF01709.20 EFC41650.1 - 0.0074 15.7 1.2 0.014 14.8 1.2 1.4 1 0 0 1 1 1 1 Transcriptional regulator NmrA PF05368.13 EFC41650.1 - 0.017 14.6 1.3 0.028 14.0 1.3 1.4 1 0 0 1 1 1 0 NmrA-like family GDP_Man_Dehyd PF16363.5 EFC41650.1 - 0.019 14.4 0.2 0.027 13.9 0.2 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_2 PF03446.15 EFC41650.1 - 0.064 13.4 2.2 0.095 12.9 1.4 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase SSP160 PF06933.11 EFC41651.1 - 1.9 6.6 8.3 2.8 6.1 8.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Ras PF00071.22 EFC41652.1 - 4.8e-45 153.1 0.0 6e-45 152.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41652.1 - 8.8e-29 100.2 0.0 1.4e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41652.1 - 1.2e-11 44.4 0.0 1.6e-11 44.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC41652.1 - 3.7e-05 23.2 0.0 4.8e-05 22.8 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFC41652.1 - 0.00013 21.5 0.1 0.0047 16.4 0.0 2.1 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EFC41652.1 - 0.00094 18.7 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EFC41652.1 - 0.0022 18.0 0.0 0.004 17.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC41652.1 - 0.0023 17.5 0.1 0.094 12.2 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DLIC PF05783.11 EFC41652.1 - 0.0027 16.6 0.1 0.25 10.1 0.1 2.1 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) G-alpha PF00503.20 EFC41652.1 - 0.0029 16.8 0.1 0.13 11.4 0.1 2.1 2 0 0 2 2 2 1 G-protein alpha subunit PduV-EutP PF10662.9 EFC41652.1 - 0.0081 15.9 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFC41652.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EFC41652.1 - 0.018 14.4 0.6 0.096 12.1 0.1 2.2 2 1 1 3 3 3 0 Bacterial TniB protein ATP_bind_1 PF03029.17 EFC41652.1 - 0.019 14.8 0.1 4.6 7.0 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein TsaE PF02367.17 EFC41652.1 - 0.027 14.5 0.1 0.14 12.2 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 EFC41652.1 - 0.051 13.9 0.0 0.12 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_32 PF13654.6 EFC41652.1 - 0.057 12.2 0.1 0.057 12.2 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC41652.1 - 0.065 13.6 0.0 0.14 12.6 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 EFC41652.1 - 0.066 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MCM PF00493.23 EFC41652.1 - 0.12 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain p450 PF00067.22 EFC41653.1 - 3.4e-75 253.6 0.2 4.3e-75 253.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 SmaI PF17411.2 EFC41653.1 - 0.0098 15.1 0.1 0.018 14.2 0.1 1.4 1 0 0 1 1 1 1 Type II site-specific deoxyribonuclease Polysacc_deac_1 PF01522.21 EFC41654.1 - 0.071 13.0 0.2 0.082 12.8 0.2 1.1 1 0 0 1 1 1 0 Polysaccharide deacetylase PP2 PF14299.6 EFC41655.1 - 0.1 12.6 0.0 0.28 11.2 0.0 1.4 1 1 0 1 1 1 0 Phloem protein 2 Glyco_hydro_20 PF00728.22 EFC41657.1 - 2.9e-92 309.8 0.1 3.5e-92 309.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFC41657.1 - 2.9e-10 40.9 0.0 5.5e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like WD40 PF00400.32 EFC41658.1 - 0.00036 21.3 0.1 0.48 11.4 0.1 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat Aldo_ket_red PF00248.21 EFC41659.1 - 1.7e-13 50.4 0.7 4.2e-12 45.9 0.1 2.7 2 1 0 2 2 2 1 Aldo/keto reductase family TelA PF05816.11 EFC41659.1 - 0.0036 16.4 1.4 0.053 12.6 0.3 2.4 2 0 0 2 2 2 1 Toxic anion resistance protein (TelA) PGAP1 PF07819.13 EFC41659.1 - 1.3 8.7 5.7 0.32 10.7 1.1 2.2 2 0 0 2 2 2 0 PGAP1-like protein Ribosomal_S4e PF00900.20 EFC41660.1 - 1.8e-32 111.1 0.2 1.8e-32 111.1 0.2 2.0 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 EFC41660.1 - 8.5e-20 70.1 0.1 1.5e-19 69.3 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 EFC41660.1 - 1.1e-16 60.7 8.8 2.7e-16 59.4 8.8 1.8 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 EFC41660.1 - 4.3e-06 26.4 0.1 8.9e-06 25.3 0.1 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 EFC41660.1 - 1e-05 25.3 2.0 1.6e-05 24.6 0.1 2.3 2 1 0 2 2 2 1 KOW motif Sipho_tail PF05709.11 EFC41660.1 - 0.053 12.9 0.7 0.11 11.9 0.6 1.8 1 1 0 1 1 1 0 Phage tail protein TetR_C_5 PF08360.11 EFC41661.1 - 0.11 12.7 0.6 0.28 11.4 0.1 1.9 2 0 0 2 2 2 0 QacR-like protein, C-terminal region Cupin_8 PF13621.6 EFC41662.1 - 9.1e-23 81.3 0.0 1.1e-22 81.0 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_1 PF00190.22 EFC41662.1 - 0.022 14.4 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Cupin JmjC PF02373.22 EFC41662.1 - 0.063 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_4 PF08007.12 EFC41662.1 - 0.066 12.7 0.0 0.27 10.7 0.0 1.9 1 1 0 1 1 1 0 Cupin superfamily protein FNIP_N PF14636.6 EFC41663.1 - 0.13 13.2 0.0 0.13 13.2 0.0 2.4 2 1 0 2 2 2 0 Folliculin-interacting protein N-terminus DUF5386 PF17360.2 EFC41664.1 - 0.064 13.2 0.9 0.13 12.2 0.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5386) AAA_lid_1 PF17857.1 EFC41665.1 - 0.019 15.2 0.2 0.081 13.1 0.1 2.0 1 1 2 3 3 3 0 AAA+ lid domain Ank_5 PF13857.6 EFC41665.1 - 0.027 14.8 0.0 1.4 9.3 0.0 2.4 1 1 1 2 2 2 0 Ankyrin repeats (many copies) AAA PF00004.29 EFC41666.1 - 6.8e-16 58.9 0.0 1.3e-15 58.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EFC41666.1 - 6.5e-09 36.0 0.1 0.00032 20.7 0.0 2.6 3 0 0 3 3 3 2 BCS1 N terminal AAA_5 PF07728.14 EFC41666.1 - 0.00028 20.9 0.0 0.0013 18.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC41666.1 - 0.0025 18.2 0.0 0.0037 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 EFC41666.1 - 0.0088 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_6 PF12774.7 EFC41666.1 - 0.013 14.5 0.0 0.027 13.4 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_11 PF13086.6 EFC41666.1 - 0.019 14.7 0.2 0.038 13.8 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC41666.1 - 0.023 14.2 0.2 0.063 12.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 EFC41666.1 - 0.04 13.3 0.0 0.073 12.4 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 EFC41666.1 - 0.047 13.4 0.1 0.18 11.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC41666.1 - 0.08 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC41666.1 - 0.14 12.7 0.0 0.34 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFC41666.1 - 0.14 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFC41666.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFC41666.1 - 0.51 10.8 10.6 0.12 12.8 0.9 3.9 4 1 0 4 4 3 0 RNA helicase RGS PF00615.19 EFC41667.1 - 3.3e-08 33.8 2.9 3.3e-08 33.8 2.9 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain STELLO PF03385.17 EFC41667.1 - 0.024 13.5 2.2 0.038 12.8 2.2 1.2 1 0 0 1 1 1 0 STELLO glycosyltransferases CCDC53 PF10152.9 EFC41667.1 - 0.028 14.8 4.6 0.055 13.9 4.6 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4116 PF13475.6 EFC41669.1 - 3e-13 49.3 12.7 0.00053 19.7 0.1 6.1 5 1 1 6 6 6 5 Domain of unknown function (DUF4116) SUKH_5 PF14567.6 EFC41669.1 - 0.026 14.2 0.2 0.1 12.3 0.1 2.0 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall SMI1_KNR4 PF09346.10 EFC41669.1 - 0.043 14.2 1.0 0.19 12.1 1.0 2.4 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) DUF2263 PF10021.9 EFC41672.1 - 5.7e-17 62.4 0.0 5.7e-17 62.4 0.0 2.7 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) ALMT PF11744.8 EFC41672.1 - 9 5.0 10.5 5.5 5.7 8.4 1.6 1 1 0 1 1 1 0 Aluminium activated malate transporter SH2 PF00017.24 EFC41673.1 - 8.1e-08 32.3 0.1 3.3e-07 30.3 0.1 2.1 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 EFC41673.1 - 0.042 14.6 0.6 0.042 14.6 0.6 2.3 3 0 0 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain MapZ_C2 PF18708.1 EFC41673.1 - 0.053 13.8 0.4 0.15 12.4 0.4 1.7 1 0 0 1 1 1 0 MapZ extracellular C-terminal domain 2 Ras PF00071.22 EFC41674.1 - 3.4e-08 33.2 0.6 0.0024 17.5 0.0 2.6 2 1 1 3 3 3 2 Ras family RsgA_GTPase PF03193.16 EFC41674.1 - 0.0015 18.4 0.0 0.075 12.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFC41674.1 - 0.0018 17.9 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC41674.1 - 0.0032 17.0 0.0 0.058 12.8 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EFC41674.1 - 0.0042 17.3 0.7 0.018 15.3 0.0 2.4 2 2 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EFC41674.1 - 0.023 14.1 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein DUF4984 PF16372.5 EFC41674.1 - 0.066 13.1 0.0 0.17 11.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4984) ABC_tran PF00005.27 EFC41674.1 - 0.13 12.8 0.0 0.27 11.7 0.0 1.7 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFC41674.1 - 0.2 12.0 0.0 0.4 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 EFC41674.1 - 0.26 11.8 1.3 0.41 11.2 0.2 2.1 2 1 0 2 2 2 0 AAA domain Kelch_4 PF13418.6 EFC41676.1 - 8.6e-25 86.5 0.7 6.3e-05 22.9 0.0 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC41676.1 - 2.7e-20 72.1 1.6 0.0012 19.1 0.0 7.1 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC41676.1 - 4.7e-15 54.9 8.2 0.0017 17.9 0.1 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 EFC41676.1 - 3.2e-14 52.5 7.4 0.042 13.9 0.0 5.8 6 0 0 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EFC41676.1 - 1e-13 50.7 8.5 0.00061 19.7 0.1 6.4 6 1 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 EFC41676.1 - 8.4e-12 44.9 4.2 0.0078 16.5 0.0 5.3 6 0 0 6 6 6 3 Kelch motif Vps8 PF12816.7 EFC41677.1 - 5.3e-14 52.2 8.4 8.7e-12 45.0 1.5 4.9 5 0 0 5 5 5 1 Golgi CORVET complex core vacuolar protein 8 Blo-t-5 PF11642.8 EFC41677.1 - 0.0014 18.6 1.8 0.0014 18.6 1.8 2.2 2 0 0 2 2 2 1 Mite allergen Blo t 5 zf-RING_2 PF13639.6 EFC41677.1 - 0.023 15.0 9.6 0.071 13.5 9.6 2.0 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 EFC41677.1 - 0.12 12.3 4.3 0.4 10.6 4.3 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC41677.1 - 0.15 12.0 7.7 0.44 10.5 7.7 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Corazonin PF17308.2 EFC41677.1 - 0.91 9.9 8.7 0.49 10.8 0.2 4.1 2 0 0 2 2 2 0 Pro-corazonin zf-rbx1 PF12678.7 EFC41677.1 - 0.94 9.8 7.5 2.8 8.3 7.5 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain ORC_WH_C PF18137.1 EFC41677.1 - 7.9 6.6 9.3 0.25 11.4 0.4 3.1 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal Arm PF00514.23 EFC41678.1 - 2.9e-06 27.1 0.1 0.2 11.8 0.2 3.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFC41678.1 - 0.0095 16.3 0.0 0.12 12.8 0.0 2.7 1 1 1 2 2 2 1 HEAT repeats MbeB_N PF04837.12 EFC41678.1 - 0.042 14.2 1.0 0.52 10.7 0.1 2.9 2 0 0 2 2 2 0 MbeB-like, N-term conserved region ANAPC3 PF12895.7 EFC41678.1 - 0.052 13.8 0.2 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF643 PF04867.12 EFC41678.1 - 0.065 13.9 1.9 0.098 13.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF643) Ras PF00071.22 EFC41679.1 - 6.7e-48 162.4 0.0 7.9e-48 162.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41679.1 - 4.1e-19 69.0 0.0 7.3e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41679.1 - 3.6e-06 26.5 0.0 4.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CTP_transf_like PF01467.26 EFC41680.1 - 5.5e-07 29.9 0.0 1.5e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like DUF3342 PF11822.8 EFC41680.1 - 0.008 16.4 4.4 0.028 14.6 4.4 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3342) FAD_syn PF06574.12 EFC41680.1 - 0.029 14.3 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 FAD synthetase Aldolase_II PF00596.21 EFC41682.1 - 2.5e-35 122.1 0.0 3e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Dynactin_p62 PF05502.13 EFC41683.1 - 0.023 13.5 24.9 0.017 14.0 8.3 2.9 1 1 2 3 3 3 0 Dynactin p62 family DUF4045 PF13254.6 EFC41683.1 - 0.46 10.1 17.0 0.66 9.6 17.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF4407 PF14362.6 EFC41683.1 - 0.69 9.2 6.2 1.8 7.8 2.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) AAA_11 PF13086.6 EFC41683.1 - 1.5 8.5 18.8 0.22 11.3 13.0 2.2 2 0 0 2 2 2 0 AAA domain Alg6_Alg8 PF03155.15 EFC41684.1 - 4.6e-74 250.2 22.3 5.2e-74 250.0 22.3 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Trep_Strep PF09605.10 EFC41684.1 - 0.0016 18.4 11.5 0.039 13.9 0.0 2.7 2 1 0 2 2 2 2 Hypothetical bacterial integral membrane protein (Trep_Strep) RasGAP PF00616.19 EFC41685.1 - 6e-26 91.4 2.7 3.9e-24 85.5 1.0 3.3 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Myosin_TH1 PF06017.13 EFC41685.1 - 0.046 13.4 0.1 0.046 13.4 0.1 2.9 3 1 0 3 3 3 0 Unconventional myosin tail, actin- and lipid-binding CRAL_TRIO PF00650.20 EFC41685.1 - 0.085 12.6 1.8 0.18 11.5 0.3 2.3 2 0 0 2 2 2 0 CRAL/TRIO domain Fes1 PF08609.10 EFC41686.1 - 8.7e-13 49.0 0.1 2.1e-12 47.8 0.1 1.6 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 SIL1 PF16782.5 EFC41686.1 - 6.4e-06 25.6 0.9 8.7e-06 25.2 0.9 1.2 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 Imm48 PF15574.6 EFC41686.1 - 0.0049 16.6 0.3 3.2 7.5 0.1 2.2 2 0 0 2 2 2 2 Immunity protein 48 WW PF00397.26 EFC41688.1 - 8.5e-07 29.0 0.1 1.8e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 WW domain NUC130_3NT PF08158.12 EFC41688.1 - 1.2 9.5 3.3 4.8 7.6 1.0 2.7 2 0 0 2 2 2 0 NUC130/3NT domain F-box-like PF12937.7 EFC41689.1 - 0.0004 20.2 0.1 0.00075 19.3 0.1 1.4 1 0 0 1 1 1 1 F-box-like PTPRCAP PF15713.5 EFC41689.1 - 0.0063 16.8 6.9 0.011 16.1 6.9 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated Sigma70_ner PF04546.13 EFC41689.1 - 0.0092 15.9 6.7 0.014 15.3 6.7 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region UBA_e1_thiolCys PF10585.9 EFC41689.1 - 0.012 15.6 3.6 0.024 14.5 3.2 1.6 1 1 0 1 1 1 0 Ubiquitin-activating enzyme active site PRANC PF09372.10 EFC41689.1 - 0.016 15.6 2.7 0.092 13.1 0.1 2.6 2 0 0 2 2 2 0 PRANC domain GCIP PF13324.6 EFC41689.1 - 0.02 14.5 5.9 0.026 14.1 5.9 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Cnd2 PF05786.14 EFC41689.1 - 0.051 12.2 9.5 0.08 11.6 9.5 1.3 1 0 0 1 1 1 0 Condensin complex subunit 2 CDC45 PF02724.14 EFC41689.1 - 0.052 11.8 8.9 0.066 11.5 8.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Gar1 PF04410.14 EFC41689.1 - 0.12 12.2 8.0 0.24 11.1 8.0 1.5 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region RRN3 PF05327.11 EFC41689.1 - 0.21 10.1 6.3 0.25 9.9 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RPN2_C PF18004.1 EFC41689.1 - 0.31 11.0 12.4 0.56 10.1 12.4 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Sporozoite_P67 PF05642.11 EFC41689.1 - 0.64 8.0 7.3 0.84 7.6 7.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 EFC41689.1 - 0.76 10.2 13.2 1.6 9.1 13.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 EFC41689.1 - 0.88 10.0 17.1 0.38 11.1 11.4 2.5 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EFC41689.1 - 0.93 8.7 11.2 1.4 8.1 11.2 1.2 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 EFC41689.1 - 1.1 8.6 10.6 1.6 8.1 10.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 EFC41689.1 - 1.5 8.5 11.4 2.7 7.7 11.3 1.5 1 1 0 1 1 1 0 FAM176 family Peptidase_C2 PF00648.21 EFC41690.1 - 1.8e-49 168.3 0.0 3.7e-49 167.4 0.0 1.4 1 1 0 1 1 1 1 Calpain family cysteine protease Rhomboid PF01694.22 EFC41691.1 - 2.1e-07 31.1 7.2 2.5e-07 30.8 5.7 1.7 1 1 1 2 2 2 1 Rhomboid family DUF1751 PF08551.10 EFC41691.1 - 0.016 15.7 1.8 0.016 15.7 1.8 1.8 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) DUF2061 PF09834.9 EFC41691.1 - 4.8 7.8 7.9 3.3 8.3 0.3 2.7 2 1 1 3 3 3 0 Predicted membrane protein (DUF2061) RGS PF00615.19 EFC41692.1 - 3e-07 30.7 5.4 8.5e-07 29.3 5.4 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain RCC1 PF00415.18 EFC41693.1 - 2.3e-19 69.8 21.2 9.9e-07 29.3 0.2 9.5 9 2 0 9 9 9 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC41693.1 - 3.9e-17 61.6 39.5 3.4e-06 26.7 0.1 10.0 9 1 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC41693.1 - 4.3e-09 36.6 37.0 4.8e-05 23.6 10.0 3.9 3 0 0 3 3 3 2 EGF-like domain Hira PF07569.11 EFC41693.1 - 0.2 11.4 0.1 16 5.1 0.0 3.0 3 0 0 3 3 3 0 TUP1-like enhancer of split DUF4116 PF13475.6 EFC41694.1 - 2.2e-52 174.5 51.8 7.2e-10 38.4 0.2 13.7 6 4 9 15 15 15 15 Domain of unknown function (DUF4116) DUF4241 PF14025.6 EFC41695.1 - 0.00015 22.2 0.1 0.036 14.3 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF4241) ABC_tran PF00005.27 EFC41696.1 - 6.1e-18 65.7 0.2 1.4e-17 64.5 0.0 1.8 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 EFC41696.1 - 0.006 16.5 0.2 0.014 15.3 0.2 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC41696.1 - 0.12 12.2 0.2 0.34 10.7 0.2 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 EFC41696.1 - 0.3 11.2 0.8 2 8.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain DUF2207 PF09972.9 EFC41697.1 - 0.0011 17.9 9.6 0.003 16.4 9.5 1.6 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4201 PF13870.6 EFC41698.1 - 0.0064 16.2 10.9 0.011 15.5 10.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) AviRa PF11599.8 EFC41698.1 - 0.013 15.0 1.0 0.014 14.8 1.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa DUF2433 PF10360.9 EFC41698.1 - 0.026 14.6 0.6 0.034 14.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) SesA PF17107.5 EFC41698.1 - 0.037 14.2 5.2 0.051 13.8 5.2 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Nup88 PF10168.9 EFC41698.1 - 0.36 8.6 10.2 0.45 8.3 10.2 1.0 1 0 0 1 1 1 0 Nuclear pore component BRO1 PF03097.18 EFC41699.1 - 1.9e-19 69.7 9.7 2.9e-19 69.1 9.7 1.3 1 0 0 1 1 1 1 BRO1-like domain DUF4666 PF15697.5 EFC41699.1 - 0.6 10.8 3.2 0.28 11.9 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) Na_trans_assoc PF06512.13 EFC41699.1 - 6.6 7.0 8.7 1 9.6 2.5 2.4 2 1 0 2 2 2 0 Sodium ion transport-associated NOG1_N PF17835.1 EFC41700.1 - 6.4e-51 172.5 0.1 1.3e-50 171.5 0.1 1.6 1 0 0 1 1 1 1 NOG1 N-terminal helical domain NOGCT PF08155.11 EFC41700.1 - 7.9e-26 89.8 1.3 2.5e-25 88.2 1.3 1.9 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 EFC41700.1 - 1.2e-24 85.8 0.0 3.3e-24 84.4 0.0 1.8 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EFC41700.1 - 8.6e-20 70.9 0.0 3.8e-19 68.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC41700.1 - 2.1e-11 43.6 0.1 4.2e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 EFC41700.1 - 2.2e-06 27.2 0.7 3.8e-05 23.1 0.1 2.6 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFC41700.1 - 0.00026 20.9 0.3 0.71 9.8 0.0 3.0 2 1 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 EFC41700.1 - 0.00029 20.9 0.8 1.4 9.0 0.0 3.4 3 1 1 4 4 4 2 Dynamin family PduV-EutP PF10662.9 EFC41700.1 - 0.003 17.3 0.0 0.0098 15.6 0.0 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFC41700.1 - 0.017 14.6 0.1 0.072 12.5 0.0 2.1 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC41700.1 - 0.021 14.2 0.1 0.04 13.3 0.1 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC41700.1 - 0.034 14.4 0.1 1.1 9.4 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC41700.1 - 0.11 12.1 0.0 0.27 10.8 0.0 1.7 1 1 0 1 1 1 0 Ras family SIR2 PF02146.17 EFC41701.1 - 5.8e-26 91.5 2.6 2e-23 83.2 0.4 3.0 2 1 0 2 2 2 1 Sir2 family TPP_enzyme_M PF00205.22 EFC41701.1 - 0.093 12.5 0.0 6.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain CCDC24 PF15669.5 EFC41701.1 - 0.14 12.0 0.4 0.24 11.3 0.4 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PNTB PF02233.16 EFC41701.1 - 0.19 10.6 0.7 3.5 6.4 0.0 2.1 2 0 0 2 2 2 0 NAD(P) transhydrogenase beta subunit zinc_ribbon_15 PF17032.5 EFC41701.1 - 0.91 10.3 6.1 11 6.9 0.5 3.1 2 0 0 2 2 2 0 zinc-ribbon family Thymosin PF01290.20 EFC41701.1 - 3.3 7.5 8.9 0.065 13.0 1.2 2.2 2 0 0 2 2 2 0 Thymosin beta-4 family Yippee-Mis18 PF03226.14 EFC41701.1 - 5.4 7.3 8.3 0.29 11.4 0.9 2.6 3 0 0 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PdaC PF13739.6 EFC41701.1 - 7.3 7.6 6.3 1.7 9.6 0.3 2.9 1 1 1 2 2 2 0 Deacetylase PdaC Pkinase PF00069.25 EFC41702.1 - 7.4e-68 228.8 0.2 1.1e-66 225.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41702.1 - 4.8e-47 160.4 0.0 1e-46 159.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC41702.1 - 3.4e-07 29.4 0.0 3.4e-07 29.4 0.0 2.0 2 1 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC41702.1 - 0.0067 15.8 0.0 0.018 14.3 0.0 1.8 1 1 0 1 1 1 1 Kinase-like PI3K_1B_p101 PF10486.9 EFC41702.1 - 0.059 11.2 14.0 0.078 10.7 14.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CopC PF04234.12 EFC41702.1 - 0.069 14.2 1.1 0.17 12.9 0.1 2.1 2 0 0 2 2 2 0 CopC domain Nore1-SARAH PF16517.5 EFC41702.1 - 0.088 12.7 9.2 0.19 11.7 6.0 2.5 1 1 1 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Transposase_mut PF00872.18 EFC41702.1 - 0.14 11.0 1.9 0.36 9.6 0.7 2.1 2 0 0 2 2 2 0 Transposase, Mutator family YlbD_coat PF14071.6 EFC41702.1 - 0.14 12.4 17.2 70 3.7 17.2 2.6 1 1 0 1 1 1 0 Putative coat protein MgtE_N PF03448.17 EFC41702.1 - 0.17 12.5 2.6 0.4 11.3 2.6 1.6 1 0 0 1 1 1 0 MgtE intracellular N domain Mst1_SARAH PF11629.8 EFC41702.1 - 0.56 10.3 11.5 0.087 12.9 6.8 2.2 2 1 1 3 3 2 0 C terminal SARAH domain of Mst1 RP-C_C PF11800.8 EFC41702.1 - 0.87 9.6 7.2 3.4 7.7 7.2 1.9 1 1 0 1 1 1 0 Replication protein C C-terminal region Menin PF05053.13 EFC41702.1 - 3.6 5.8 8.5 4.8 5.4 8.5 1.1 1 0 0 1 1 1 0 Menin TFIIF_alpha PF05793.12 EFC41702.1 - 9.6 4.7 29.9 1.6 7.3 12.0 2.2 1 1 1 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Peptidase_C2 PF00648.21 EFC41703.1 - 7.2e-07 28.5 0.0 7.2e-07 28.5 0.0 2.7 3 0 0 3 3 3 1 Calpain family cysteine protease DUF4116 PF13475.6 EFC41704.1 - 1.2e-13 50.5 2.8 1.2e-11 44.1 0.1 3.3 2 2 1 3 3 3 2 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC41705.1 - 1.7e-06 27.6 1.5 1.7e-06 27.6 1.5 3.5 2 2 2 4 4 4 1 Protein kinase domain MIF PF01187.18 EFC41707.1 - 0.073 13.4 0.0 1.6 9.1 0.0 2.2 2 0 0 2 2 2 0 Macrophage migration inhibitory factor (MIF) Ost5 PF05251.12 EFC41707.1 - 0.086 13.1 0.0 0.23 11.7 0.0 1.8 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 MgrB PF13998.6 EFC41708.1 - 1.8 8.5 3.8 14 5.7 0.9 2.7 2 0 0 2 2 2 0 MgrB protein ADH_zinc_N PF00107.26 EFC41710.1 - 1.4e-18 67.1 0.0 2.1e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC41710.1 - 3.8e-11 42.8 0.2 6.9e-11 42.0 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ERCC3_RAD25_C PF16203.5 EFC41711.1 - 4.4e-110 366.7 2.2 4.4e-110 366.7 2.2 2.3 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EFC41711.1 - 1.3e-26 93.2 0.0 2.7e-26 92.2 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C PF00271.31 EFC41711.1 - 5.8e-14 52.4 0.8 7.2e-13 48.8 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC41711.1 - 9.9e-12 45.2 0.0 9.9e-12 45.2 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF3638 PF12340.8 EFC41711.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) Trypsin_2 PF13365.6 EFC41712.1 - 0.2 12.5 0.0 3.3 8.6 0.0 2.4 1 1 0 1 1 1 0 Trypsin-like peptidase domain DUF1657 PF07870.11 EFC41713.1 - 0.01 15.7 0.1 1.2 9.1 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF1657) BACK PF07707.15 EFC41714.1 - 1.5e-16 60.4 0.5 2.9e-14 53.0 0.0 2.3 1 1 1 2 2 2 2 BTB And C-terminal Kelch Gly_rich PF12810.7 EFC41714.1 - 7e-11 42.5 55.5 1.7e-10 41.3 55.5 1.6 1 1 0 1 1 1 1 Glycine rich protein BTB PF00651.31 EFC41714.1 - 2.2e-05 24.7 0.0 4.2e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Pkinase PF00069.25 EFC41715.1 - 4.2e-06 26.3 0.0 6.9e-06 25.6 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain REJ PF02010.15 EFC41715.1 - 9.4e-05 21.4 0.8 0.00016 20.6 0.6 1.4 2 0 0 2 2 2 1 REJ domain Pkinase_fungal PF17667.1 EFC41715.1 - 0.012 14.4 0.0 0.019 13.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Y_Y_Y PF07495.13 EFC41715.1 - 0.044 13.7 1.0 0.088 12.8 1.0 1.5 1 0 0 1 1 1 0 Y_Y_Y domain L_protein_N PF15518.6 EFC41715.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 L protein N-terminus APH PF01636.23 EFC41715.1 - 0.28 11.1 0.1 0.37 10.7 0.1 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family TMEM223 PF14640.6 EFC41716.1 - 1.5e-09 38.2 0.9 3.7e-09 37.0 0.1 2.0 2 1 0 2 2 2 1 Transmembrane protein 223 MT PF12777.7 EFC41718.1 - 0.065 12.3 0.0 0.083 11.9 0.0 1.1 1 0 0 1 1 1 0 Microtubule-binding stalk of dynein motor Trypsin PF00089.26 EFC41720.1 - 1.5e-14 54.4 0.2 2.2e-14 53.8 0.2 1.2 1 0 0 1 1 1 1 Trypsin DUF316 PF03761.15 EFC41720.1 - 0.015 14.9 0.2 0.025 14.1 0.2 1.5 1 1 0 1 1 1 0 Chymotrypsin family Peptidase-S1 DEADboxA PF12343.8 EFC41721.1 - 0.46 11.0 2.7 0.98 10.0 2.7 1.4 1 0 0 1 1 1 0 Cold shock protein DEAD box A HP0268 PF18618.1 EFC41721.1 - 3.6 8.1 9.2 3.5 8.1 0.9 3.3 3 0 0 3 3 3 0 HP0268 ADP_ribosyl_GH PF03747.14 EFC41722.1 - 1.2e-31 110.6 0.0 1.7e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase CM_2 PF01817.21 EFC41722.1 - 0.075 13.4 0.1 0.69 10.3 0.1 2.7 1 1 0 1 1 1 0 Chorismate mutase type II Gly-zipper_Omp PF13488.6 EFC41722.1 - 0.1 12.6 0.8 14 5.8 0.2 2.3 2 0 0 2 2 2 0 Glycine zipper SRP-alpha_N PF04086.13 EFC41723.1 - 0.29 11.0 20.4 0.26 11.2 7.3 2.3 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal SR-25 PF10500.9 EFC41723.1 - 1.6 8.3 24.3 0.096 12.3 6.8 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Suf PF05843.14 EFC41723.1 - 3.8 7.4 17.7 4.9 7.1 4.7 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 EFC41723.1 - 6.8 5.3 20.0 2.9 6.6 5.3 2.2 2 0 0 2 2 2 0 Presenilin Ephrin_rec_like PF07699.13 EFC41724.1 - 3e-48 161.3 100.8 6.1e-08 32.3 6.8 11.0 2 1 8 10 10 10 10 Putative ephrin-receptor like Pkinase_Tyr PF07714.17 EFC41724.1 - 4e-48 163.9 0.0 1.1e-43 149.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC41724.1 - 6.5e-47 160.1 0.0 1.9e-46 158.6 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain NCD3G PF07562.14 EFC41724.1 - 1.7e-08 34.3 75.5 0.096 12.7 3.4 10.3 8 2 2 11 11 11 9 Nine Cysteines Domain of family 3 GPCR EGF_2 PF07974.13 EFC41724.1 - 3.1e-07 30.6 35.0 0.015 15.6 4.4 4.4 3 0 0 3 3 3 3 EGF-like domain Haspin_kinase PF12330.8 EFC41724.1 - 0.011 14.7 0.0 0.023 13.7 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFC41724.1 - 0.024 13.7 0.1 0.084 11.9 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 Stevor PF17410.2 EFC41724.1 - 0.063 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame APH PF01636.23 EFC41724.1 - 0.15 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SBBP PF06739.11 EFC41724.1 - 1.1 9.3 6.4 11 6.1 0.3 4.4 3 0 0 3 3 3 0 Beta-propeller repeat GCP_N_terminal PF17681.1 EFC41725.1 - 8.9e-23 81.4 13.0 2.4e-22 80.0 13.0 1.7 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFC41725.1 - 2.8e-15 56.6 0.8 2.8e-15 56.6 0.8 2.6 3 0 0 3 3 3 1 Gamma tubulin complex component C-terminal Methyltransf_11 PF08241.12 EFC41726.1 - 1.6e-20 73.5 0.0 2.3e-20 73.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC41726.1 - 1.1e-17 64.6 0.0 1.6e-17 64.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC41726.1 - 2.1e-16 60.2 0.0 2.6e-16 59.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC41726.1 - 1.8e-15 56.9 0.1 2.3e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFC41726.1 - 1e-11 45.4 0.0 1.6e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC41726.1 - 4.2e-10 39.6 0.0 5.8e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Pox_MCEL PF03291.16 EFC41726.1 - 0.014 14.6 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Methyltransf_8 PF05148.15 EFC41726.1 - 0.052 13.4 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Penicil_amidase PF01804.18 EFC41727.1 - 6.4e-157 524.4 0.0 8e-157 524.1 0.0 1.0 1 0 0 1 1 1 1 Penicillin amidase DUF2477 PF10631.9 EFC41729.1 - 0.16 12.6 0.3 0.39 11.4 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) UPF0239 PF06783.11 EFC41729.1 - 5.2 7.3 0.0 5.2 7.3 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) Alpha_Helical PF18489.1 EFC41730.1 - 0.52 10.5 4.9 1.1 9.5 5.0 1.5 1 1 0 1 1 1 0 Alpha helical domain Macoilin PF09726.9 EFC41730.1 - 6.4 5.2 20.5 0.013 14.1 9.3 1.8 2 0 0 2 2 2 0 Macoilin family Vps35 PF03635.17 EFC41731.1 - 6.5e-214 712.6 24.0 7.4e-214 712.4 24.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Vps35 PF03635.17 EFC41732.1 - 8e-15 54.4 0.3 9.7e-15 54.1 0.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 B3_4 PF03483.17 EFC41732.1 - 0.047 13.4 0.1 0.055 13.1 0.1 1.2 1 0 0 1 1 1 0 B3/4 domain DUF3399 PF11879.8 EFC41732.1 - 0.081 13.3 0.6 0.33 11.3 0.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3399) DUF763 PF05559.11 EFC41732.1 - 0.14 11.3 0.1 0.17 11.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF763) OppC_N PF12911.7 EFC41732.1 - 2 8.4 5.8 0.28 11.2 1.1 1.9 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Guanylate_cyc PF00211.20 EFC41734.1 - 1.9e-53 180.8 1.0 4e-52 176.5 0.5 2.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC41734.1 - 3.4e-15 56.2 0.4 1.8e-14 53.8 0.2 2.5 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC41734.1 - 2.5e-06 27.5 0.0 5.3e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC41734.1 - 0.0086 15.5 0.2 0.0086 15.5 0.2 2.0 2 0 0 2 2 2 1 Heme NO binding associated PMP1_2 PF08114.11 EFC41734.1 - 0.023 14.4 0.5 0.071 12.9 0.5 1.8 1 0 0 1 1 1 0 ATPase proteolipid family Triabin PF03973.13 EFC41734.1 - 0.031 14.2 0.2 0.09 12.7 0.2 1.7 1 0 0 1 1 1 0 Triabin PAS_8 PF13188.7 EFC41734.1 - 0.035 14.1 0.0 0.093 12.8 0.0 1.7 1 0 0 1 1 1 0 PAS domain DUF4023 PF13215.6 EFC41734.1 - 0.04 13.9 0.1 0.11 12.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) PHA_synth_III_E PF09712.10 EFC41734.1 - 0.72 8.9 4.7 0.65 9.0 2.0 2.0 2 0 0 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) LON_substr_bdg PF02190.16 EFC41735.1 - 7.1e-28 97.9 0.0 7.1e-28 97.9 0.0 2.8 2 2 0 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 EFC41735.1 - 1.1e-07 31.6 8.7 2.7e-07 30.3 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC41735.1 - 4.3e-07 29.9 4.6 4.3e-07 29.9 4.6 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFC41735.1 - 2.3e-06 27.4 7.4 6.4e-06 25.9 7.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC41735.1 - 6.6e-06 26.4 9.1 6.6e-06 26.4 9.1 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFC41735.1 - 1.2e-05 25.3 10.5 4.2e-05 23.6 10.5 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING U-box PF04564.15 EFC41735.1 - 4.2e-05 23.7 0.0 0.00021 21.4 0.0 2.2 1 0 0 1 1 1 1 U-box domain zf-C3HC4 PF00097.25 EFC41735.1 - 0.00023 20.9 7.9 0.00092 19.0 7.9 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 EFC41735.1 - 0.00097 18.9 7.0 0.0035 17.1 7.0 2.0 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 EFC41735.1 - 0.0023 17.8 7.3 0.0083 16.0 7.0 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFC41735.1 - 0.0031 17.5 8.4 0.013 15.5 8.4 2.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 EFC41735.1 - 0.096 12.5 1.5 0.29 10.9 1.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 EFC41735.1 - 0.12 12.4 3.0 0.5 10.5 3.0 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PPI_Ypi1 PF07491.11 EFC41736.1 - 0.053 13.4 1.1 0.15 11.9 1.1 1.7 1 0 0 1 1 1 0 Protein phosphatase inhibitor SecA_SW PF07516.13 EFC41736.1 - 0.13 12.2 2.9 0.45 10.5 2.8 1.8 2 0 0 2 2 2 0 SecA Wing and Scaffold domain DUF2681 PF10883.8 EFC41738.1 - 0.043 14.2 6.9 0.11 12.9 6.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Patched PF02460.18 EFC41738.1 - 1.4 6.9 8.8 0.022 12.9 1.5 1.5 2 0 0 2 2 2 0 Patched family DUF4267 PF14087.6 EFC41739.1 - 0.00013 22.0 0.9 0.00017 21.7 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) Otopetrin PF03189.13 EFC41740.1 - 0.025 13.4 0.1 0.075 11.8 0.0 2.1 2 1 0 2 2 2 0 Otopetrin LRR_6 PF13516.6 EFC41741.1 - 5.6e-26 88.3 12.0 0.0031 17.5 0.1 7.4 7 0 0 7 7 7 7 Leucine Rich repeat LRR_4 PF12799.7 EFC41741.1 - 3.6e-16 59.0 20.0 5.5e-05 23.4 1.9 4.8 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC41741.1 - 9.3e-16 57.3 17.3 1.4e-07 31.2 5.0 3.5 3 1 0 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 EFC41741.1 - 7.6e-10 38.0 10.8 0.92 10.3 0.2 7.2 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC41741.1 - 7.2e-05 22.4 0.2 0.035 13.6 0.0 2.2 1 1 1 2 2 2 2 Leucine-rich repeat DUF563 PF04577.14 EFC41742.1 - 0.00021 21.5 0.1 0.0011 19.1 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF563) DUF2207 PF09972.9 EFC41742.1 - 0.00044 19.1 2.5 0.02 13.7 0.1 3.0 3 0 0 3 3 3 2 Predicted membrane protein (DUF2207) PP_kinase_C_1 PF17941.1 EFC41742.1 - 0.014 15.0 0.0 0.043 13.4 0.0 1.8 2 0 0 2 2 2 0 Polyphosphate kinase C-terminal domain 1 RNA_binding PF01877.17 EFC41742.1 - 0.02 15.1 0.9 0.79 10.0 0.2 2.9 2 0 0 2 2 2 0 RNA binding DUF1676 PF07898.13 EFC41742.1 - 0.39 10.7 2.1 0.74 9.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) SUR7 PF06687.12 EFC41743.1 - 0.00015 21.5 11.2 0.00042 20.0 2.4 2.2 2 0 0 2 2 2 2 SUR7/PalI family DUF2165 PF09933.9 EFC41743.1 - 0.016 15.2 4.2 0.31 11.1 0.3 2.4 2 0 0 2 2 2 0 Predicted small integral membrane protein (DUF2165) SpoIIM PF01944.17 EFC41743.1 - 0.032 14.3 5.3 0.12 12.4 0.8 2.3 2 0 0 2 2 2 0 Stage II sporulation protein M GWT1 PF06423.12 EFC41743.1 - 3.9 7.6 8.3 2.4e+02 1.8 8.1 2.8 1 1 0 1 1 1 0 GWT1 TMEM100 PF16311.5 EFC41743.1 - 5.1 6.7 8.8 0.47 10.1 0.4 2.9 3 0 0 3 3 3 0 Transmembrane protein 100 RCC1_2 PF13540.6 EFC41744.1 - 0.038 13.8 0.2 0.1 12.5 0.2 1.8 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat FAD_binding_4 PF01565.23 EFC41745.1 - 5.2e-24 84.6 0.0 1e-23 83.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EFC41745.1 - 8.1e-07 28.9 0.0 3e-05 23.8 0.0 2.4 2 0 0 2 2 2 2 FAD linked oxidases, C-terminal domain FKBP_C PF00254.28 EFC41746.1 - 7.8e-31 106.3 0.0 1.3e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF1068 PF06364.12 EFC41747.1 - 0.0015 18.5 1.0 0.0019 18.1 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1068) V_ATPase_I PF01496.19 EFC41747.1 - 0.031 12.2 0.0 0.037 12.0 0.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 EFC41748.1 - 5.5e-39 134.3 22.7 7.9e-28 97.6 7.7 3.2 1 1 2 3 3 3 3 ZIP Zinc transporter Presenilin PF01080.17 EFC41748.1 - 0.013 14.3 0.1 0.042 12.6 0.0 2.0 2 0 0 2 2 2 0 Presenilin TMEM51 PF15345.6 EFC41748.1 - 0.026 14.4 0.2 1.2 8.9 0.0 2.5 2 0 0 2 2 2 0 Transmembrane protein 51 DUF1980 PF09323.10 EFC41748.1 - 0.033 14.1 0.6 0.4 10.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) SID-1_RNA_chan PF13965.6 EFC41748.1 - 0.082 11.3 0.5 0.17 10.3 0.5 1.5 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 EFC41748.1 - 0.97 10.4 6.2 0.78 10.7 1.2 3.0 3 1 0 3 3 2 0 Domain of unknown function (DUF4834) Rab_eff_C PF04698.12 EFC41748.1 - 1.2 7.3 5.9 1.7 6.8 5.9 1.1 1 0 0 1 1 1 0 Rab effector MyRIP/melanophilin C-terminus V_ATPase_I PF01496.19 EFC41748.1 - 2.3 6.0 10.1 3.7 5.3 10.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 EFC41748.1 - 2.5 8.1 4.3 6.1 6.8 4.3 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Bap31 PF05529.12 EFC41748.1 - 3.5 7.5 0.0 3.5 7.5 0.0 3.2 3 1 0 3 3 3 0 Bap31/Bap29 transmembrane region Macoilin PF09726.9 EFC41748.1 - 5.1 5.5 11.8 8.6 4.8 11.8 1.3 1 0 0 1 1 1 0 Macoilin family EphA2_TM PF14575.6 EFC41748.1 - 7.3 7.5 9.5 15 6.5 0.0 3.9 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Arf PF00025.21 EFC41749.1 - 3.1e-44 150.5 0.5 3.7e-44 150.2 0.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC41749.1 - 3.5e-19 69.0 0.0 4.3e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41749.1 - 1.7e-16 60.5 0.0 2.9e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC41749.1 - 5.6e-12 45.5 0.1 6.6e-12 45.2 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC41749.1 - 4.3e-09 36.1 0.0 4.9e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC41749.1 - 1.3e-08 34.9 0.1 2.2e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFC41749.1 - 3.5e-07 29.7 0.5 3.3e-05 23.2 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 EFC41749.1 - 1.1e-05 25.1 0.1 0.00083 18.9 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFC41749.1 - 0.026 14.0 2.6 0.25 10.9 2.6 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC41749.1 - 0.039 14.0 0.0 2 8.5 0.1 2.2 1 1 1 2 2 2 0 Dynamin family PduV-EutP PF10662.9 EFC41749.1 - 0.079 12.7 0.1 8.6 6.1 0.1 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 EFC41749.1 - 0.14 11.6 0.1 0.24 10.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region LRR_4 PF12799.7 EFC41751.1 - 2.2e-05 24.7 28.0 0.066 13.7 1.4 7.5 2 2 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC41751.1 - 3.5e-05 23.5 29.5 0.0063 16.5 0.5 8.7 10 0 0 10 10 10 2 Leucine Rich repeat LRR_8 PF13855.6 EFC41751.1 - 0.52 10.1 20.4 1.7 8.5 0.5 5.7 5 2 2 7 7 7 0 Leucine rich repeat LRR_1 PF00560.33 EFC41751.1 - 8.3 7.4 22.8 16 6.5 0.6 6.9 7 1 0 7 7 7 0 Leucine Rich Repeat Lipase_3 PF01764.25 EFC41752.1 - 1.4e-26 93.0 0.1 1.4e-26 93.0 0.1 4.2 3 1 0 3 3 3 1 Lipase (class 3) DUF2974 PF11187.8 EFC41752.1 - 5.2e-07 29.5 0.5 5.2e-07 29.5 0.5 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Apolipoprotein PF01442.18 EFC41752.1 - 3.5e-06 27.0 1.5 9.3e-05 22.4 1.4 2.7 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain PGAP1 PF07819.13 EFC41752.1 - 0.0013 18.5 0.9 0.0037 17.0 0.4 2.1 2 1 0 2 2 2 1 PGAP1-like protein Baculo_PEP_C PF04513.12 EFC41752.1 - 0.0043 17.1 9.5 0.89 9.6 0.2 4.3 1 1 0 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 EFC41752.1 - 0.0059 16.8 8.3 0.0059 16.8 8.3 3.9 2 1 1 4 4 4 2 Fibrinogen alpha/beta chain family MEIOC PF15189.6 EFC41752.1 - 0.041 13.5 13.7 0.92 9.1 5.6 3.1 1 1 1 2 2 2 0 Meiosis-specific coiled-coil domain-containing protein MEIOC DUF1664 PF07889.12 EFC41752.1 - 0.078 13.0 23.5 0.27 11.3 4.4 4.1 1 1 4 5 5 5 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 EFC41752.1 - 0.08 12.5 19.8 0.12 11.9 4.8 3.6 1 1 2 3 3 3 0 fzo-like conserved region Hydrolase_4 PF12146.8 EFC41752.1 - 0.084 12.1 0.0 0.26 10.5 0.0 1.9 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Exonuc_VII_L PF02601.15 EFC41752.1 - 0.16 11.5 29.9 0.35 10.4 6.4 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit WXG100 PF06013.12 EFC41752.1 - 0.56 10.5 3.2 30 4.9 0.1 4.6 3 1 2 5 5 5 0 Proteins of 100 residues with WXG DUF2884 PF11101.8 EFC41752.1 - 0.82 9.1 21.7 0.021 14.4 3.3 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2884) DUF2280 PF10045.9 EFC41752.1 - 0.85 9.9 9.2 6.8 7.0 1.4 2.8 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2280) ZYG-11_interact PF05884.12 EFC41752.1 - 1.2 8.5 8.0 70 2.7 8.0 2.8 1 1 0 1 1 1 0 Interactor of ZYG-11 ApoO PF09769.9 EFC41752.1 - 2.6 8.0 18.8 2.3 8.2 0.8 4.5 4 1 1 5 5 5 0 Apolipoprotein O YtxH PF12732.7 EFC41752.1 - 3 8.4 42.7 0.86 10.2 4.4 5.5 1 1 4 5 5 5 0 YtxH-like protein RGS PF00615.19 EFC41753.1 - 1.2e-07 32.0 6.0 1.5e-06 28.4 6.0 2.7 1 1 0 1 1 1 1 Regulator of G protein signaling domain Hum_adeno_E3A PF05393.11 EFC41753.1 - 0.045 13.7 1.6 0.92 9.5 0.1 2.7 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein ArsC PF03960.15 EFC41753.1 - 1.5 8.9 5.0 22 5.1 0.0 2.9 3 0 0 3 3 3 0 ArsC family RNA_pol_Rpb1_5 PF04998.17 EFC41754.1 - 8.4e-104 346.7 0.2 8.4e-104 346.7 0.2 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EFC41754.1 - 1.1e-92 310.7 2.1 1.1e-92 310.7 2.1 3.2 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EFC41754.1 - 1.1e-73 247.0 0.1 2.5e-73 245.8 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EFC41754.1 - 3.5e-60 203.1 0.0 8.9e-60 201.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EFC41754.1 - 4.5e-47 159.9 0.0 1.7e-46 158.0 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EFC41754.1 - 1.1e-42 145.3 9.4 1.1e-42 145.3 9.4 2.9 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EFC41754.1 - 5.7e-38 129.2 0.5 1.8e-37 127.5 0.5 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 EFC41754.1 - 1.1e-14 53.8 270.0 0.006 16.9 11.4 14.6 7 2 10 19 19 19 15 RNA polymerase Rpb1 C-terminal repeat CBFD_NFYB_HMF PF00808.23 EFC41754.1 - 0.037 14.3 0.7 0.23 11.8 0.7 2.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone V-ATPase_G_2 PF16999.5 EFC41754.1 - 0.45 10.9 4.8 1.4 9.4 4.8 1.8 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit FACT-Spt16_Nlob PF14826.6 EFC41754.1 - 0.55 10.0 3.9 0.3 10.9 0.4 2.4 2 0 0 2 2 2 0 FACT complex subunit SPT16 N-terminal lobe domain Cyclin_N PF00134.23 EFC41755.1 - 1.9e-05 24.4 2.4 2.8e-05 23.8 0.2 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain GP3_package PF16677.5 EFC41755.1 - 0.093 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 DNA-packaging protein gp3 ATP12 PF07542.11 EFC41755.1 - 0.31 11.1 1.9 2 8.5 0.1 2.4 2 0 0 2 2 2 0 ATP12 chaperone protein RGS PF00615.19 EFC41756.1 - 7.6e-15 55.2 4.1 8.2e-15 55.1 1.4 2.4 2 1 0 2 2 2 1 Regulator of G protein signaling domain AhpC-TSA PF00578.21 EFC41756.1 - 0.023 14.6 0.4 0.084 12.8 0.1 2.1 2 0 0 2 2 2 0 AhpC/TSA family Musclin PF11037.8 EFC41756.1 - 0.08 12.9 0.2 0.23 11.4 0.2 1.9 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle Flg_bbr_C PF06429.13 EFC41756.1 - 0.084 13.0 0.1 0.85 9.8 0.0 2.6 3 0 0 3 3 3 0 Flagellar basal body rod FlgEFG protein C-terminal RNA_pol_Rpb1_5 PF04998.17 EFC41756.1 - 1.2 8.5 3.3 0.52 9.7 0.1 1.9 2 1 0 2 2 2 0 RNA polymerase Rpb1, domain 5 EF-hand_3 PF09069.11 EFC41757.1 - 0.33 11.4 3.0 0.56 10.7 0.1 2.9 3 1 1 4 4 4 0 EF-hand Abhydrolase_3 PF07859.13 EFC41758.1 - 1e-17 64.7 0.0 2.5e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFC41758.1 - 5.7e-15 55.2 0.0 3.5e-14 52.6 0.0 2.0 1 1 0 2 2 2 1 Carboxylesterase family Tir_receptor_C PF07489.11 EFC41758.1 - 0.78 9.7 6.6 1.4 8.9 6.6 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus GPI-anchored PF10342.9 EFC41758.1 - 1.5 9.6 6.7 0.71 10.7 2.9 2.3 2 1 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Trypan_PARP PF05887.11 EFC41759.1 - 0.00011 22.1 60.6 0.0038 17.2 33.5 2.0 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) DUF1690 PF07956.11 EFC41760.1 - 0.039 14.4 5.6 1.1 9.7 1.8 2.6 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) RGS PF00615.19 EFC41762.1 - 2.2e-08 34.4 0.1 8.2e-08 32.5 0.2 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain HTH_Mga PF08280.11 EFC41762.1 - 0.015 15.3 1.3 1.9 8.6 0.4 2.5 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain DUF3402 PF11882.8 EFC41762.1 - 0.31 10.1 4.0 5.2 6.1 0.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF3402) GST_C_3 PF14497.6 EFC41763.1 - 1.7e-16 60.2 0.0 3.3e-16 59.3 0.0 1.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC41763.1 - 1.9e-06 28.1 0.0 5.3e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC41763.1 - 1e-05 25.6 0.0 1.6e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC41763.1 - 0.016 15.6 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 EFC41763.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_N_4 PF17172.4 EFC41763.1 - 0.082 13.7 0.0 0.19 12.5 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain DUF4116 PF13475.6 EFC41765.1 - 1.7e-23 82.1 9.0 2.7e-09 36.6 1.0 3.5 2 1 1 3 3 3 3 Domain of unknown function (DUF4116) Myb_DNA-binding PF00249.31 EFC41767.1 - 0.065 13.4 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain YlbD_coat PF14071.6 EFC41767.1 - 0.96 9.7 5.5 0.82 9.9 3.1 2.2 2 0 0 2 2 2 0 Putative coat protein PI-PLC-X PF00388.19 EFC41768.1 - 4e-61 204.9 0.0 1e-60 203.5 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFC41768.1 - 1e-32 112.9 0.1 3.3e-32 111.2 0.1 1.9 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EFC41768.1 - 1.3e-09 38.2 0.0 4.6e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 C2 domain EF-hand_1 PF00036.32 EFC41768.1 - 4.3e-08 32.2 0.1 0.00012 21.4 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC41768.1 - 3.1e-07 30.7 0.1 1.4e-06 28.7 0.1 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC41768.1 - 2.7e-06 26.9 0.5 0.0047 16.8 0.0 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.6 EFC41768.1 - 5.6e-05 22.9 0.2 0.00016 21.5 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EFC41768.1 - 0.0045 16.4 0.5 3.3 7.4 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC41768.1 - 0.0079 16.0 0.0 0.027 14.3 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_4 PF12763.7 EFC41768.1 - 0.029 14.3 0.3 14 5.6 0.1 3.1 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_like PF09279.11 EFC41768.1 - 0.048 14.2 2.3 0.084 13.4 0.5 2.4 2 1 0 2 2 2 0 Phosphoinositide-specific phospholipase C, efhand-like Patatin PF01734.22 EFC41770.1 - 4.7e-05 23.6 0.5 0.00012 22.4 0.1 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase DUF908 PF06012.12 EFC41770.1 - 0.015 14.7 12.8 0.025 14.0 12.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Endostatin PF06482.11 EFC41770.1 - 0.17 11.4 4.5 0.29 10.5 4.5 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Lactococcin PF04369.13 EFC41770.1 - 0.23 11.6 0.0 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 Lactococcin-like family DUF2981 PF11200.8 EFC41770.1 - 3 7.5 6.1 6.7 6.3 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Neurensin PF14927.6 EFC41771.1 - 0.019 14.7 1.1 0.55 9.9 0.2 2.3 2 0 0 2 2 2 0 Neurensin DUF3185 PF11381.8 EFC41771.1 - 0.095 12.7 3.7 3.4 7.7 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) DUF1349 PF07081.11 EFC41772.1 - 2.3e-50 170.8 0.3 3.5e-50 170.2 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) GH43_C2 PF17851.1 EFC41772.1 - 0.00026 20.8 0.3 0.00045 20.0 0.2 1.5 1 1 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_32C PF08244.12 EFC41772.1 - 0.056 13.4 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 32 C terminal EMP24_GP25L PF01105.24 EFC41773.1 - 3.5e-26 92.3 0.0 4.4e-26 91.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4349 PF14257.6 EFC41773.1 - 0.16 11.4 0.1 0.29 10.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) F-box-like PF12937.7 EFC41774.1 - 0.032 14.1 0.2 0.083 12.8 0.2 1.7 1 0 0 1 1 1 0 F-box-like Clr2_transil PF16761.5 EFC41774.1 - 0.072 13.9 0.4 0.31 11.9 0.0 2.3 2 0 0 2 2 2 0 Transcription-silencing protein, cryptic loci regulator Clr2 FA_hydroxylase PF04116.13 EFC41775.1 - 6.2e-24 84.8 22.6 6.2e-24 84.8 22.6 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily LUC7 PF03194.15 EFC41776.1 - 0.0011 18.7 0.9 0.0011 18.7 0.9 1.2 1 0 0 1 1 1 1 LUC7 N_terminus AAA_13 PF13166.6 EFC41776.1 - 0.0016 17.1 2.1 0.0016 17.1 2.1 1.1 1 0 0 1 1 1 1 AAA domain MCPsignal PF00015.21 EFC41776.1 - 0.0022 17.9 8.2 0.0039 17.0 8.2 1.5 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain zf-C4H2 PF10146.9 EFC41776.1 - 0.0062 16.9 1.2 0.0066 16.8 1.2 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein Spc7 PF08317.11 EFC41776.1 - 0.016 14.1 10.5 0.023 13.6 10.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2303 PF10065.9 EFC41776.1 - 0.029 13.5 2.6 0.041 13.0 2.6 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) DUF1664 PF07889.12 EFC41776.1 - 0.035 14.1 11.9 0.077 13.0 11.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 EFC41776.1 - 0.067 13.1 3.8 0.12 12.2 3.8 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF3418 PF11898.8 EFC41776.1 - 0.073 11.7 0.5 0.11 11.2 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) Laminin_II PF06009.12 EFC41776.1 - 0.077 13.0 9.8 0.16 12.0 9.8 1.5 1 0 0 1 1 1 0 Laminin Domain II Mce4_CUP1 PF11887.8 EFC41776.1 - 0.079 12.4 2.3 0.11 12.0 2.3 1.2 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative YkyA PF10368.9 EFC41776.1 - 0.084 12.5 15.8 0.13 11.9 15.8 1.3 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Kre28 PF17097.5 EFC41776.1 - 0.12 11.3 11.7 0.15 10.9 11.7 1.2 1 0 0 1 1 1 0 Spindle pole body component Fib_alpha PF08702.10 EFC41776.1 - 0.17 12.0 11.0 0.34 11.1 11.0 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FTCD_C PF04961.12 EFC41776.1 - 0.21 11.3 4.2 0.36 10.6 4.2 1.3 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DASH_Duo1 PF08651.10 EFC41776.1 - 0.26 11.1 7.6 0.35 10.7 4.0 2.5 1 1 1 2 2 2 0 DASH complex subunit Duo1 APG17 PF04108.12 EFC41776.1 - 0.27 10.3 6.4 0.36 9.9 6.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Activator-TraM PF11657.8 EFC41776.1 - 0.32 10.8 5.9 7.2 6.4 0.0 2.9 2 1 1 3 3 3 0 Transcriptional activator TraM DUF3450 PF11932.8 EFC41776.1 - 0.38 10.0 8.3 0.61 9.4 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) COG2 PF06148.11 EFC41776.1 - 0.47 10.5 9.0 1.4 9.0 9.0 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 V_ATPase_I PF01496.19 EFC41776.1 - 0.49 8.3 10.2 0.012 13.5 3.8 1.5 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.12 EFC41776.1 - 0.51 10.8 15.1 1.1 9.7 10.6 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 EFC41776.1 - 0.57 9.4 8.8 1 8.6 8.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein HIP1_clath_bdg PF16515.5 EFC41776.1 - 0.57 10.8 9.8 1.3 9.7 9.8 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Spc42p PF11544.8 EFC41776.1 - 0.59 10.2 11.6 0.32 11.0 3.4 2.7 1 1 1 2 2 2 0 Spindle pole body component Spc42p RmuC PF02646.16 EFC41776.1 - 0.61 9.2 10.2 1.7 7.7 2.4 2.2 1 1 1 2 2 2 0 RmuC family Prefoldin_2 PF01920.20 EFC41776.1 - 0.74 9.8 20.1 0.22 11.5 5.3 2.7 2 1 1 3 3 2 0 Prefoldin subunit DUF16 PF01519.16 EFC41776.1 - 0.75 10.3 12.0 1.8 9.1 12.0 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF16 Tweety PF04906.13 EFC41776.1 - 0.76 8.4 3.0 1.1 7.8 3.0 1.3 1 0 0 1 1 1 0 Tweety CREPT PF16566.5 EFC41776.1 - 0.9 9.7 7.0 1.9 8.7 7.0 1.5 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Goodbye PF17109.5 EFC41776.1 - 0.9 10.0 4.0 6.2 7.3 2.1 2.5 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain DUF3818 PF12825.7 EFC41776.1 - 1.4 7.9 10.1 4.3 6.3 7.5 2.1 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) PHM7_cyt PF14703.6 EFC41776.1 - 1.4 9.1 8.2 0.5 10.6 4.9 1.9 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter AI-2E_transport PF01594.16 EFC41776.1 - 1.5 7.9 7.8 2.4e+02 0.7 7.8 2.6 1 1 0 1 1 1 0 AI-2E family transporter ISG65-75 PF11727.8 EFC41776.1 - 1.6 7.9 8.4 2.7 7.1 8.4 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein Allexi_40kDa PF05549.11 EFC41776.1 - 1.6 8.1 4.6 2.4 7.6 4.6 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Baculo_PEP_C PF04513.12 EFC41776.1 - 1.7 8.7 13.6 5.4 7.0 13.6 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HAP1_N PF04849.13 EFC41776.1 - 1.8 7.7 11.5 3.3 6.8 10.3 1.9 2 0 0 2 2 2 0 HAP1 N-terminal conserved region DUF4407 PF14362.6 EFC41776.1 - 1.9 7.8 6.7 3.4 6.9 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TBCC_N PF16752.5 EFC41776.1 - 1.9 8.9 11.1 4.4 7.8 2.9 2.8 2 1 1 3 3 2 0 Tubulin-specific chaperone C N-terminal domain DHR10 PF18595.1 EFC41776.1 - 2 8.5 11.7 30 4.7 10.1 2.3 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF948 PF06103.11 EFC41776.1 - 2 8.7 14.4 5.2 7.4 3.2 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1910 PF08928.10 EFC41776.1 - 2.2 8.3 5.8 10 6.1 5.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) DUF4200 PF13863.6 EFC41776.1 - 2.2 8.7 20.3 0.27 11.7 15.5 1.9 2 1 0 2 2 1 0 Domain of unknown function (DUF4200) OmpH PF03938.14 EFC41776.1 - 2.2 8.6 15.9 8.5 6.7 15.9 2.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1098 PF06497.11 EFC41776.1 - 2.2 8.8 6.2 0.71 10.4 3.2 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF1098) Nup88 PF10168.9 EFC41776.1 - 2.3 5.9 9.2 2.8 5.6 9.2 1.1 1 0 0 1 1 1 0 Nuclear pore component eIF3_N PF09440.10 EFC41776.1 - 3.2 8.2 9.9 12 6.3 9.7 2.0 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain TPR_MLP1_2 PF07926.12 EFC41776.1 - 3.2 7.8 13.7 0.52 10.4 9.6 1.8 2 1 0 2 2 1 0 TPR/MLP1/MLP2-like protein TraF_2 PF13729.6 EFC41776.1 - 4.2 6.7 6.7 9.9 5.4 6.6 1.7 1 1 0 1 1 1 0 F plasmid transfer operon, TraF, protein PRKCSH-like PF12999.7 EFC41776.1 - 4.4 7.1 7.0 7.3 6.4 7.0 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like Fzo_mitofusin PF04799.13 EFC41776.1 - 4.9 6.7 6.6 14 5.2 6.6 1.8 1 1 0 1 1 1 0 fzo-like conserved region Enkurin PF13864.6 EFC41776.1 - 5.3 7.6 10.1 19 5.7 9.5 2.1 2 0 0 2 2 2 0 Calmodulin-binding HMMR_N PF15905.5 EFC41776.1 - 8.7 5.7 17.2 10 5.5 3.5 2.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal KxDL PF10241.9 EFC41776.1 - 8.8 6.7 11.1 2.9 8.2 6.9 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF2203 PF09969.9 EFC41776.1 - 9.7 6.9 8.3 6.6 7.5 0.9 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) RGS PF00615.19 EFC41777.1 - 4.9e-09 36.5 5.4 4.9e-09 36.5 5.4 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain Snf7 PF03357.21 EFC41777.1 - 0.18 11.4 5.1 0.35 10.5 5.1 1.4 1 0 0 1 1 1 0 Snf7 F-box-like PF12937.7 EFC41779.1 - 2.4e-10 40.1 0.7 6.8e-10 38.7 0.7 1.8 1 0 0 1 1 1 1 F-box-like ClpS PF02617.17 EFC41779.1 - 2.7e-05 23.9 0.1 0.03 14.1 0.2 2.6 2 0 0 2 2 2 2 ATP-dependent Clp protease adaptor protein ClpS F-box PF00646.33 EFC41779.1 - 0.00022 21.0 0.1 0.00056 19.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain ANAPC3 PF12895.7 EFC41780.1 - 0.18 12.1 2.4 0.41 10.9 1.4 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3560 PF12083.8 EFC41780.1 - 0.38 10.9 5.4 1.8 8.7 1.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) TPR_1 PF00515.28 EFC41780.1 - 1.4 8.9 3.9 35 4.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Robl_LC7 PF03259.17 EFC41784.1 - 0.0021 17.8 0.1 3.1 7.6 0.0 3.1 3 0 0 3 3 3 2 Roadblock/LC7 domain CotE PF10628.9 EFC41784.1 - 0.02 14.5 0.0 0.033 13.8 0.0 1.5 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) ICA69 PF04629.14 EFC41784.1 - 0.028 14.7 1.0 0.039 14.3 1.0 1.2 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain SLM4 PF16818.5 EFC41784.1 - 0.044 13.8 0.2 0.069 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein SLM4 Ras PF00071.22 EFC41785.1 - 7.4e-16 58.2 0.1 1.5e-10 40.9 0.0 2.5 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC41785.1 - 7.6e-07 29.4 0.7 1.1e-05 25.7 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41785.1 - 0.00019 21.0 0.2 0.2 11.1 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC41785.1 - 0.015 15.4 0.4 0.16 12.0 0.0 3.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase Esterase PF00756.20 EFC41786.1 - 5.2e-19 68.9 0.0 6.5e-19 68.6 0.0 1.1 1 0 0 1 1 1 1 Putative esterase ThiC-associated PF13667.6 EFC41787.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 1 0 0 1 1 1 0 ThiC-associated domain DUF2062 PF09835.9 EFC41787.1 - 0.19 11.5 0.3 0.39 10.6 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) Ras PF00071.22 EFC41788.1 - 8.1e-28 97.1 0.1 1.2e-27 96.5 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41788.1 - 1.2e-12 48.1 0.0 2.5e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC41788.1 - 3e-05 23.6 0.5 0.0012 18.5 0.5 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like_2 PF13013.6 EFC41788.1 - 0.0051 16.8 0.1 0.015 15.2 0.1 1.8 1 0 0 1 1 1 1 F-box-like domain MMR_HSR1 PF01926.23 EFC41788.1 - 0.013 15.5 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase 6PF2K PF01591.18 EFC41788.1 - 0.019 14.2 0.5 0.044 13.1 0.1 1.8 2 0 0 2 2 2 0 6-phosphofructo-2-kinase MMR_HSR1_Xtn PF16897.5 EFC41788.1 - 0.054 13.5 0.1 0.19 11.8 0.1 1.9 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain F-box PF00646.33 EFC41788.1 - 0.088 12.7 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 F-box domain PQ-loop PF04193.14 EFC41789.1 - 3.8e-19 68.2 22.0 2.4e-14 52.8 1.0 3.1 3 0 0 3 3 3 2 PQ loop repeat Tmemb_9 PF05434.11 EFC41789.1 - 0.025 14.5 4.9 1.4 8.8 0.0 3.1 3 0 0 3 3 3 0 TMEM9 Sigma_reg_N PF13800.6 EFC41789.1 - 0.7 10.2 3.9 2.3 8.6 0.0 3.0 3 1 0 3 3 3 0 Sigma factor regulator N-terminal DUF563 PF04577.14 EFC41790.1 - 6.5e-19 68.9 0.1 1e-18 68.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) CarbpepA_inh PF02977.15 EFC41790.1 - 1 9.2 3.7 1.9 8.4 3.7 1.4 1 0 0 1 1 1 0 Carboxypeptidase A inhibitor Shisa PF13908.6 EFC41791.1 - 0.00027 21.2 3.3 0.00027 21.2 3.3 2.0 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator DUF5305 PF17231.2 EFC41791.1 - 0.017 14.5 0.8 0.032 13.6 0.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Collagen_bind PF05737.12 EFC41791.1 - 3.5 7.8 7.5 3.4 7.8 4.9 2.3 2 1 1 3 3 3 0 Collagen binding domain RCR PF12273.8 EFC41792.1 - 0.29 11.8 28.9 0.097 13.3 24.9 2.1 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red KKLCAg1 PF15204.6 EFC41792.1 - 2.5 8.3 5.3 7.5 6.7 5.3 1.8 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 Peptidase_M32 PF02074.15 EFC41793.1 - 1.9e-156 521.7 1.6 2.2e-156 521.4 1.6 1.0 1 0 0 1 1 1 1 Carboxypeptidase Taq (M32) metallopeptidase MTH865 PF07747.11 EFC41793.1 - 0.037 13.8 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 MTH865-like family DUF4883 PF16224.5 EFC41795.1 - 0.05 13.9 0.5 0.082 13.2 0.5 1.4 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) AcetylCoA_hyd_C PF13336.6 EFC41796.1 - 2.7e-60 202.8 0.4 4.7e-60 202.0 0.4 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 EFC41796.1 - 1.8e-21 77.1 1.9 6.8e-21 75.2 0.0 2.6 2 1 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain DeoRC PF00455.22 EFC41796.1 - 0.027 14.4 0.0 0.074 13.0 0.0 1.7 1 0 0 1 1 1 0 DeoR C terminal sensor domain GxGYxYP_N PF16216.5 EFC41796.1 - 0.11 12.6 2.8 0.38 10.9 0.1 2.2 2 0 0 2 2 2 0 GxGYxY sequence motif in domain of unknown function N-terminal Adaptin_N PF01602.20 EFC41797.1 - 2.5e-150 501.5 14.4 3.3e-150 501.1 14.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFC41797.1 - 2.1e-61 206.7 8.4 4.3e-59 199.2 1.2 3.5 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EFC41797.1 - 4.1e-21 75.2 0.0 1.2e-20 73.6 0.0 1.9 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 EFC41797.1 - 9.8e-18 64.3 3.8 1.8e-08 34.6 0.1 5.7 2 2 3 5 5 5 4 HEAT repeats HEAT PF02985.22 EFC41797.1 - 6.9e-10 38.3 0.5 0.024 14.9 0.0 6.0 6 0 0 6 6 6 2 HEAT repeat Cnd3 PF12719.7 EFC41797.1 - 6.4e-07 28.8 1.5 7e-06 25.4 0.1 2.7 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 EFC41797.1 - 1.1e-06 28.7 6.5 0.055 13.6 0.1 4.5 2 2 2 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 EFC41797.1 - 2.4e-06 27.4 0.2 0.026 14.6 0.0 5.0 3 1 1 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC41797.1 - 1.1e-05 25.8 0.2 0.62 10.6 0.0 4.7 5 0 0 5 5 4 2 HEAT-like repeat Arm_2 PF04826.13 EFC41797.1 - 0.0047 16.4 2.8 0.083 12.3 0.2 2.7 1 1 1 2 2 2 1 Armadillo-like Alpha_adaptinC2 PF02883.20 EFC41797.1 - 0.0059 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain DUF5578 PF17741.1 EFC41797.1 - 0.0068 15.9 1.6 0.2 11.0 0.4 3.0 2 1 0 2 2 2 1 Family of unknown function (DUF5578) CCAP PF11105.8 EFC41797.1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a RIX1 PF08167.12 EFC41797.1 - 0.048 13.4 0.0 11 5.8 0.0 3.5 2 1 1 3 3 3 0 rRNA processing/ribosome biogenesis Phage_TAC_12 PF12363.8 EFC41797.1 - 0.13 12.7 3.0 1.2 9.5 0.1 3.6 3 0 0 3 3 3 0 Phage tail assembly chaperone protein, TAC Mo25 PF08569.11 EFC41797.1 - 0.51 9.6 6.2 1.7 7.9 0.3 3.2 2 1 1 3 3 3 0 Mo25-like Aa_trans PF01490.18 EFC41798.1 - 4.8e-28 98.0 38.3 6.8e-15 54.7 29.1 3.0 2 1 0 2 2 2 2 Transmembrane amino acid transporter protein Tmemb_9 PF05434.11 EFC41798.1 - 0.11 12.4 1.0 0.52 10.2 0.0 2.6 2 0 0 2 2 2 0 TMEM9 ATP_bind_2 PF03668.15 EFC41799.1 - 1.6e-10 40.8 0.1 0.0002 20.8 0.0 2.1 2 0 0 2 2 2 2 P-loop ATPase protein family DNA_pol_phi PF04931.13 EFC41799.1 - 8.3e-05 20.9 22.3 0.00011 20.6 22.3 1.2 1 0 0 1 1 1 1 DNA polymerase phi BUD22 PF09073.10 EFC41799.1 - 0.00025 20.5 15.8 0.00028 20.4 15.8 1.2 1 0 0 1 1 1 1 BUD22 CobT PF06213.12 EFC41799.1 - 0.00079 18.9 14.6 0.0011 18.4 14.6 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 EFC41799.1 - 0.0036 15.6 20.8 0.0044 15.3 20.8 1.2 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 EFC41799.1 - 0.0055 16.2 18.1 0.0077 15.7 18.1 1.4 1 0 0 1 1 1 1 SDA1 RNA_pol_3_Rpc31 PF11705.8 EFC41799.1 - 0.0066 16.7 24.5 0.012 15.9 24.5 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 RRN3 PF05327.11 EFC41799.1 - 0.007 15.0 12.8 0.0088 14.6 12.8 1.3 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF2428 PF10350.9 EFC41799.1 - 0.012 14.9 3.6 0.017 14.4 3.6 1.3 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) CDC45 PF02724.14 EFC41799.1 - 0.051 11.9 17.8 0.073 11.3 17.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF3530 PF12048.8 EFC41799.1 - 0.06 12.8 2.4 0.36 10.2 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) Paf1 PF03985.13 EFC41799.1 - 0.098 11.6 19.9 0.03 13.3 17.6 1.4 2 0 0 2 2 2 0 Paf1 Hydrolase_3 PF08282.12 EFC41799.1 - 0.13 11.9 9.7 0.14 11.8 4.3 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Tim54 PF11711.8 EFC41799.1 - 0.2 10.4 8.2 0.29 9.9 8.2 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CSRNP_N PF16019.5 EFC41799.1 - 0.25 11.2 6.4 0.45 10.4 6.4 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus CPSF100_C PF13299.6 EFC41799.1 - 0.35 11.0 7.4 0.18 12.0 5.4 1.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FYDLN_acid PF09538.10 EFC41799.1 - 0.55 10.9 21.1 1.1 9.9 21.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Astro_capsid_p PF12226.8 EFC41799.1 - 0.59 9.2 20.5 0.84 8.7 20.5 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RNA_pol_Rpc4 PF05132.14 EFC41799.1 - 0.7 10.3 4.7 1.3 9.5 4.7 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 TFB6 PF17110.5 EFC41799.1 - 0.79 9.5 9.3 1.3 8.7 9.3 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF913 PF06025.12 EFC41799.1 - 0.79 8.6 6.4 1.1 8.1 6.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 EFC41799.1 - 1.1 7.9 6.0 1.1 7.9 6.0 1.2 1 0 0 1 1 1 0 Presenilin VIR_N PF15912.5 EFC41799.1 - 1.5 8.4 12.4 2.2 7.8 12.4 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal TRAP_alpha PF03896.16 EFC41799.1 - 1.6 7.9 14.2 2.9 7.0 14.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1115 PF06544.12 EFC41799.1 - 2.2 8.4 7.8 5.8 7.0 7.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) Connexin PF00029.19 EFC41799.1 - 2.3 7.9 4.5 3.2 7.5 4.5 1.4 1 0 0 1 1 1 0 Connexin PTPRCAP PF15713.5 EFC41799.1 - 2.4 8.4 18.6 6.4 7.1 18.6 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4637 PF15470.6 EFC41799.1 - 2.5 7.8 22.3 0.071 12.8 15.7 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4637) DUF4746 PF15928.5 EFC41799.1 - 2.7 7.3 18.8 4.2 6.7 18.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GCIP PF13324.6 EFC41799.1 - 3 7.4 13.1 4.9 6.7 13.1 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting SPOUT_MTase PF02590.17 EFC41799.1 - 3.5 7.6 7.2 16 5.5 7.2 2.0 1 1 0 1 1 1 0 Predicted SPOUT methyltransferase DUF4407 PF14362.6 EFC41799.1 - 3.5 6.9 8.7 4.4 6.6 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Eapp_C PF10238.9 EFC41799.1 - 5.5 7.0 11.7 18 5.4 11.6 2.0 1 1 0 1 1 1 0 E2F-associated phosphoprotein Muted PF14942.6 EFC41801.1 - 0.0052 17.1 1.6 0.0081 16.5 1.6 1.2 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein Dna2 PF08696.11 EFC41801.1 - 0.0062 16.4 1.6 0.0082 16.0 1.6 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 GLTSCR1 PF15249.6 EFC41801.1 - 0.016 15.6 0.2 0.032 14.7 0.2 1.6 1 0 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein SMC_ScpA PF02616.14 EFC41801.1 - 0.02 14.8 0.2 0.024 14.5 0.2 1.1 1 0 0 1 1 1 0 Segregation and condensation protein ScpA Mucin PF01456.17 EFC41801.1 - 0.028 14.4 12.0 0.034 14.2 12.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Herpes_UL92 PF03048.14 EFC41801.1 - 0.042 13.6 0.6 0.059 13.1 0.6 1.1 1 0 0 1 1 1 0 UL92 family FliG_M PF14841.6 EFC41801.1 - 0.095 12.9 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 FliG middle domain DUF908 PF06012.12 EFC41801.1 - 4.7 6.5 15.6 5.6 6.3 15.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) L51_S25_CI-B8 PF05047.16 EFC41803.1 - 3.9e-05 23.5 0.0 6.1e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Ribosomal_S8 PF00410.19 EFC41804.1 - 1.9e-23 82.8 0.1 3.3e-23 82.0 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 V-SNARE_C PF12352.8 EFC41805.1 - 9.1e-12 45.1 3.0 9.1e-12 45.1 3.0 3.1 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 EFC41805.1 - 4e-05 23.5 9.7 8.3e-05 22.4 0.6 3.5 2 1 0 3 3 3 1 Sec20 SepSecS PF05889.13 EFC41805.1 - 0.0024 16.7 6.7 0.093 11.4 0.9 2.1 2 0 0 2 2 2 2 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Syntaxin-6_N PF09177.11 EFC41805.1 - 0.0067 17.0 8.6 0.027 15.0 0.6 2.8 1 1 2 3 3 3 1 Syntaxin 6, N-terminal DUF2362 PF10154.9 EFC41805.1 - 0.087 11.8 12.6 0.14 11.1 12.6 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2362) YejG PF13989.6 EFC41805.1 - 0.16 12.4 0.9 0.5 10.8 0.1 2.1 2 1 0 2 2 2 0 YejG-like protein DASH_Spc19 PF08287.11 EFC41805.1 - 0.16 11.8 15.7 0.21 11.4 3.1 2.8 1 1 2 3 3 3 0 Spc19 CPT_N PF16484.5 EFC41805.1 - 0.2 11.6 0.6 2.2 8.3 0.1 2.3 2 0 0 2 2 2 0 Carnitine O-palmitoyltransferase N-terminus DUF4709 PF15821.5 EFC41805.1 - 0.23 11.8 6.1 0.46 10.8 0.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) DUF948 PF06103.11 EFC41805.1 - 0.65 10.3 5.4 2.2 8.6 0.4 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2730 PF10805.8 EFC41805.1 - 1.3 9.1 4.9 0.79 9.8 0.3 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) Noelin-1 PF12308.8 EFC41805.1 - 1.8 8.6 8.0 1.6 8.8 0.4 3.1 3 1 0 3 3 3 0 Neurogenesis glycoprotein Tup_N PF08581.10 EFC41805.1 - 3.3 8.1 9.5 2.1 8.7 0.4 3.0 3 0 0 3 3 3 0 Tup N-terminal Exonuc_VII_L PF02601.15 EFC41805.1 - 4.8 6.7 12.9 25 4.3 12.9 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit BST2 PF16716.5 EFC41806.1 - 0.028 15.0 7.1 0.028 15.0 7.1 2.6 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 YtxH PF12732.7 EFC41806.1 - 0.082 13.4 1.7 9.5 6.8 1.6 2.7 2 1 0 2 2 2 0 YtxH-like protein EST1 PF10374.9 EFC41806.1 - 0.27 11.9 6.2 2.1 9.0 6.2 2.7 1 1 0 1 1 1 0 Telomerase activating protein Est1 Exonuc_VII_L PF02601.15 EFC41806.1 - 0.83 9.2 6.3 1.5 8.3 6.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_M76 PF09768.9 EFC41807.1 - 5.4e-49 166.2 1.6 7.4e-49 165.8 1.6 1.2 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M56 PF05569.11 EFC41807.1 - 0.0046 16.2 0.0 0.0079 15.4 0.0 1.3 1 0 0 1 1 1 1 BlaR1 peptidase M56 SprT-like PF10263.9 EFC41807.1 - 0.063 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 SprT-like family TPR_2 PF07719.17 EFC41808.1 - 2e-16 58.7 19.0 0.011 15.8 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41808.1 - 4.8e-15 55.6 13.8 0.00017 21.8 3.5 6.5 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41808.1 - 5.9e-13 47.9 22.9 0.0039 17.3 0.0 8.9 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC41808.1 - 6e-13 49.2 0.7 0.0053 17.4 0.8 4.6 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41808.1 - 8.5e-12 44.4 11.2 0.018 14.9 0.0 7.4 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC41808.1 - 1.4e-10 41.0 3.4 0.32 11.9 0.0 6.5 3 3 5 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC41808.1 - 7.5e-10 39.2 2.5 0.26 11.8 0.1 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC41808.1 - 1.9e-05 24.8 13.2 0.0013 18.9 0.2 4.1 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC41808.1 - 7e-05 22.9 9.0 24 5.6 0.0 7.6 7 1 1 8 8 8 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC41808.1 - 8e-05 22.4 5.3 0.15 12.0 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC41808.1 - 0.0015 18.6 0.1 0.51 10.5 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41808.1 - 0.0018 17.9 2.5 27 4.5 0.7 4.5 4 0 0 4 4 4 0 TPR repeat TPR_6 PF13174.6 EFC41808.1 - 0.01 16.4 3.1 7.2 7.5 0.3 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41808.1 - 0.014 15.4 4.3 3.3 8.0 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat HemY_N PF07219.13 EFC41808.1 - 1.8 8.8 5.5 1.5 9.1 0.0 3.3 3 1 0 4 4 4 0 HemY protein N-terminus GTP_EFTU PF00009.27 EFC41809.1 - 8.2e-66 221.3 0.0 1.2e-65 220.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFC41809.1 - 1e-30 106.0 0.0 2.7e-30 104.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFC41809.1 - 7.2e-21 74.0 0.0 1.4e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 EFC41809.1 - 3.5e-16 59.0 0.0 8.9e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFC41809.1 - 1.6e-10 41.3 0.1 1.1e-09 38.6 0.1 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC41809.1 - 0.00053 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Sel1 PF08238.12 EFC41810.1 - 2.3e-59 196.5 15.8 3.7e-09 37.0 0.0 8.6 8 0 0 8 8 8 8 Sel1 repeat DUF4116 PF13475.6 EFC41810.1 - 1.2e-36 124.2 1.1 1.6e-10 40.5 0.0 6.1 2 2 4 6 6 6 6 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC41810.1 - 7.2e-30 104.2 0.5 1.2e-29 103.6 0.5 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41810.1 - 2.4e-19 69.7 0.7 5.3e-19 68.5 0.7 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase TPR_2 PF07719.17 EFC41810.1 - 0.94 9.7 13.8 1.8 8.9 0.7 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat GNT-I PF03071.15 EFC41811.1 - 8.2e-06 24.8 2.0 1.1e-05 24.4 2.0 1.4 1 1 0 1 1 1 1 GNT-I family EGF_2 PF07974.13 EFC41812.1 - 3.1e-10 40.2 21.7 1.8e-06 28.2 8.2 3.9 5 0 0 5 5 5 2 EGF-like domain EGF PF00008.27 EFC41812.1 - 0.0017 18.6 14.4 0.059 13.7 2.2 3.0 2 0 0 2 2 2 2 EGF-like domain Fibrinogen_C PF00147.18 EFC41812.1 - 0.0081 16.0 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain hEGF PF12661.7 EFC41812.1 - 4.6 8.0 26.8 1.8 9.3 10.2 3.6 3 0 0 3 3 3 0 Human growth factor-like EGF DUF3349 PF11829.8 EFC41813.1 - 0.014 16.2 1.6 0.034 14.9 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) DUF4834 PF16118.5 EFC41814.1 - 0.019 15.9 0.1 0.35 11.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PorA PF11271.8 EFC41814.1 - 0.026 13.8 0.0 0.055 12.8 0.0 1.5 1 1 0 1 1 1 0 Porin PorA DUF2681 PF10883.8 EFC41814.1 - 0.087 13.2 0.1 0.087 13.2 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) RDD PF06271.12 EFC41814.1 - 1 9.5 4.9 1.1 9.4 0.6 2.1 2 0 0 2 2 2 0 RDD family C2-set PF05790.15 EFC41814.1 - 2.3 8.4 7.0 23 5.3 2.6 3.0 3 0 0 3 3 3 0 Immunoglobulin C2-set domain Sel1 PF08238.12 EFC41815.1 - 2.1e-20 72.7 11.2 6.4e-11 42.6 0.3 3.1 4 0 0 4 4 4 2 Sel1 repeat TPR_8 PF13181.6 EFC41815.1 - 0.0012 18.9 11.7 2.2 8.7 0.9 4.9 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41815.1 - 0.0033 17.7 2.3 0.25 11.6 0.1 3.0 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC41815.1 - 0.0079 16.8 0.9 3.6 8.4 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41815.1 - 0.031 14.3 0.9 19 5.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41815.1 - 0.065 13.1 8.8 6.5 6.7 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EFC41815.1 - 0.16 12.1 2.3 9.9 6.3 0.1 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Corona_NSP4_C PF16348.5 EFC41815.1 - 0.24 12.2 1.8 5 8.0 0.2 2.1 1 1 1 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus TPR_2 PF07719.17 EFC41815.1 - 0.39 11.0 8.4 4.7 7.6 0.2 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41815.1 - 0.62 9.8 9.8 1.9 8.3 0.2 3.3 4 0 0 4 4 4 0 TPR repeat Pkinase PF00069.25 EFC41816.1 - 3.2e-34 118.5 0.5 7.4e-34 117.3 0.5 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41816.1 - 6.7e-17 61.6 2.3 8.4e-16 58.0 0.7 2.8 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC41816.1 - 2.9e-05 23.0 0.1 6.8e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase S-AdoMet_synt_C PF02773.16 EFC41818.1 - 6.5e-68 227.0 0.4 1.3e-67 226.0 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EFC41818.1 - 1.3e-49 167.4 0.1 3.7e-49 166.0 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EFC41818.1 - 4.7e-42 142.7 1.7 5.5e-42 142.5 0.4 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EFC41818.1 - 0.056 12.2 0.3 2.4 6.9 0.1 2.3 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) PARP PF00644.20 EFC41819.1 - 1.1e-13 51.2 0.0 3.5e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF1264 PF06884.11 EFC41819.1 - 0.0031 17.1 0.0 0.012 15.2 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1264) ART-PolyVal PF18760.1 EFC41819.1 - 0.03 15.3 1.4 0.42 11.6 0.0 3.1 2 2 0 3 3 3 0 ADP-Ribosyltransferase in polyvalent proteins eIF3_p135 PF12807.7 EFC41820.1 - 0.1 12.6 0.1 0.11 12.5 0.1 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 IDEAL PF08858.10 EFC41820.1 - 0.96 9.2 5.5 0.22 11.3 1.9 1.8 2 0 0 2 2 2 0 IDEAL domain DUF2842 PF11003.8 EFC41821.1 - 0.2 12.0 0.2 0.2 12.0 0.2 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2842) Ras PF00071.22 EFC41822.1 - 2.6e-58 196.2 0.1 3.1e-58 195.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41822.1 - 1.9e-33 115.3 0.1 5.4e-33 113.7 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41822.1 - 4.9e-15 55.4 0.1 6.2e-15 55.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC41822.1 - 5.6e-06 26.4 0.0 0.065 13.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC41822.1 - 2.1e-05 24.6 0.0 4.2e-05 23.6 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC41822.1 - 4.5e-05 23.1 0.1 0.00037 20.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC41822.1 - 5.1e-05 22.8 0.1 7.3e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC41822.1 - 0.0001 21.8 0.1 0.00015 21.2 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EFC41822.1 - 0.00045 19.8 0.0 0.0028 17.2 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 EFC41822.1 - 0.0099 15.7 0.1 0.037 13.8 0.0 1.7 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 EFC41822.1 - 0.021 15.1 0.0 0.1 12.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC41822.1 - 0.024 14.4 0.0 0.057 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 EFC41822.1 - 0.036 13.8 0.3 0.54 9.9 0.1 2.2 1 1 1 2 2 2 0 AAA domain BtrH_N PF14399.6 EFC41822.1 - 0.057 13.7 0.0 11 6.3 0.0 2.3 2 0 0 2 2 2 0 Butirosin biosynthesis protein H, N-terminal AAA_16 PF13191.6 EFC41822.1 - 0.11 12.9 0.0 0.24 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 EFC41822.1 - 0.12 11.9 0.0 0.46 10.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Carot_N PF09150.10 EFC41823.1 - 0.0049 16.7 0.1 0.011 15.6 0.1 1.6 1 0 0 1 1 1 1 Orange carotenoid protein, N-terminal HEPN_AbiA_CTD PF18732.1 EFC41824.1 - 0.042 13.8 0.8 0.072 13.0 0.8 1.4 1 0 0 1 1 1 0 HEPN like, Abia C-terminal domain GPW_gp25 PF04965.14 EFC41824.1 - 0.047 13.5 0.2 0.085 12.6 0.2 1.5 1 0 0 1 1 1 0 Gene 25-like lysozyme Glyco_hydro_31 PF01055.26 EFC41825.1 - 1.8e-147 492.1 1.2 2.4e-147 491.7 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EFC41825.1 - 1.8e-26 92.6 0.5 4.6e-26 91.3 0.5 1.7 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EFC41825.1 - 6.4e-10 39.2 3.5 1e-08 35.3 1.0 3.6 3 0 0 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 EFC41825.1 - 0.0014 18.9 0.0 0.0047 17.2 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Pkinase_Tyr PF07714.17 EFC41826.1 - 1.2e-48 165.7 0.2 1.7e-48 165.1 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC41826.1 - 4e-48 164.1 0.3 6.6e-48 163.4 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC41826.1 - 1.3e-05 24.2 0.3 2.1e-05 23.5 0.3 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC41826.1 - 0.02 14.3 0.1 0.054 12.8 0.1 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC41826.1 - 0.027 14.4 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family AP_endonuc_2 PF01261.24 EFC41826.1 - 0.061 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Chlam_PMP PF02415.17 EFC41826.1 - 4.3 8.0 23.4 64 4.3 0.1 6.4 4 1 1 5 5 5 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat 2-Hacid_dh_C PF02826.19 EFC41827.1 - 3e-06 26.7 0.0 5.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DnaGprimase_HBD PF16730.5 EFC41827.1 - 0.0039 17.3 0.4 0.0073 16.4 0.1 1.6 2 0 0 2 2 2 1 DnaG-primase C-terminal, helicase-binding domain Glyco_hydro_67C PF07477.12 EFC41827.1 - 0.0095 15.5 0.1 0.016 14.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus VD10_N PF08476.10 EFC41827.1 - 0.034 13.8 1.1 13 5.5 0.2 3.3 2 1 1 3 3 3 0 Viral D10 N-terminal DUF2935 PF11155.8 EFC41827.1 - 0.057 13.8 3.1 0.6 10.5 1.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Ank_4 PF13637.6 EFC41828.1 - 6.6e-11 42.5 0.1 2.4e-05 24.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC41828.1 - 2.8e-08 33.9 0.0 3.5e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC41828.1 - 4.5e-05 23.5 0.0 0.00014 22.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 EFC41828.1 - 0.00027 21.5 0.0 0.0003 21.3 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC41828.1 - 0.0018 18.6 0.0 0.004 17.5 0.0 1.6 2 0 0 2 2 2 1 Ankyrin repeat DEAD PF00270.29 EFC41829.1 - 2e-13 50.5 0.2 9e-13 48.4 0.3 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC41829.1 - 1.3e-11 44.8 0.2 1e-10 41.9 0.0 2.7 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC41829.1 - 1.4e-07 31.7 4.4 1.9e-07 31.2 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Pkinase PF00069.25 EFC41830.1 - 5.4e-35 121.0 0.7 1.1e-34 120.0 0.7 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41830.1 - 1.4e-22 80.2 0.4 2.9e-22 79.2 0.4 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC41830.1 - 2e-22 78.0 7.6 0.013 15.5 0.0 10.8 11 0 0 11 11 11 6 NHL repeat EGF_2 PF07974.13 EFC41830.1 - 3.6e-22 78.4 150.3 0.00056 20.2 8.9 9.6 9 0 0 9 9 9 8 EGF-like domain Pkinase_fungal PF17667.1 EFC41830.1 - 0.001 17.9 0.2 0.0017 17.2 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase EGF PF00008.27 EFC41830.1 - 0.86 10.0 97.5 0.71 10.2 1.2 9.8 9 0 0 9 9 9 0 EGF-like domain G-alpha PF00503.20 EFC41831.1 - 1.1e-70 238.6 10.5 1.1e-70 238.6 10.5 1.4 2 0 0 2 2 2 1 G-protein alpha subunit Arf PF00025.21 EFC41831.1 - 2.9e-05 23.6 0.1 0.32 10.4 0.0 3.3 3 0 0 3 3 3 2 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EFC41831.1 - 0.27 11.0 3.9 1.1 9.0 0.1 3.0 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Roc PF08477.13 EFC41831.1 - 0.34 11.1 1.3 4.7 7.4 0.1 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase NHL PF01436.21 EFC41833.1 - 7.4e-19 66.8 14.3 1.3e-07 31.3 0.1 5.0 6 0 0 6 6 6 3 NHL repeat SGL PF08450.12 EFC41833.1 - 1.7e-11 44.2 0.5 0.0067 16.0 0.1 3.3 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 EFC41833.1 - 1.2e-05 24.6 2.4 1.3e-05 24.6 1.1 1.8 1 1 1 2 2 2 1 6-bladed beta-propeller DUF4934 PF16288.5 EFC41833.1 - 0.00021 21.2 2.4 0.0026 17.6 0.1 3.3 2 1 2 4 4 4 2 Domain of unknown function (DUF4934) Lactonase PF10282.9 EFC41833.1 - 0.0064 15.8 0.1 6.7 5.9 0.0 2.9 1 1 2 3 3 3 2 Lactonase, 7-bladed beta-propeller SBBP PF06739.11 EFC41833.1 - 0.01 15.8 10.4 1 9.4 1.1 4.4 4 1 0 4 4 4 0 Beta-propeller repeat DUF839 PF05787.13 EFC41833.1 - 0.021 14.0 2.0 2.7 7.1 0.0 3.4 2 1 1 4 4 4 0 Bacterial protein of unknown function (DUF839) NHL PF01436.21 EFC41834.1 - 1.5e-17 62.6 10.1 3.8e-08 33.0 0.6 4.8 5 0 0 5 5 5 3 NHL repeat SGL PF08450.12 EFC41834.1 - 1.2e-05 25.0 0.2 0.65 9.5 0.1 3.6 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EFC41834.1 - 1.4e-05 24.9 0.1 0.051 13.6 0.0 3.0 2 0 0 2 2 2 2 Beta-propeller repeat DUF5128 PF17170.4 EFC41834.1 - 0.0016 17.7 0.4 0.013 14.7 0.1 2.5 1 1 1 3 3 3 2 6-bladed beta-propeller DUF4934 PF16288.5 EFC41834.1 - 0.14 12.1 0.3 1.3 8.9 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4934) PhoPQ_related PF10142.9 EFC41835.1 - 4.8e-14 51.8 0.0 5.7e-14 51.6 0.0 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Roc PF08477.13 EFC41836.1 - 3.5e-13 49.8 0.0 8.5e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC41836.1 - 1.2e-12 47.8 0.0 1.9e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFC41836.1 - 5.2e-08 32.5 0.0 7e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFC41836.1 - 3.2e-05 23.5 0.0 4.4e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC41836.1 - 0.00092 18.7 0.0 0.0017 17.8 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 EFC41836.1 - 0.0087 16.5 0.0 0.021 15.2 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain ODC_AZ PF02100.17 EFC41836.1 - 0.012 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Ornithine decarboxylase antizyme MMR_HSR1 PF01926.23 EFC41836.1 - 0.022 14.8 0.0 0.062 13.4 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase DAP3 PF10236.9 EFC41836.1 - 0.055 12.6 0.1 0.22 10.7 0.1 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 EFC41836.1 - 0.061 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 EFC41836.1 - 0.064 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EFC41836.1 - 0.068 13.5 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 EFC41836.1 - 0.1 12.6 0.2 3 7.9 0.1 2.7 1 1 1 2 2 2 0 Dynamin family ABC_tran PF00005.27 EFC41836.1 - 0.13 12.8 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 EFC41836.1 - 0.19 11.6 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain DUF5392 PF17370.2 EFC41837.1 - 2.5 8.2 7.3 0.32 11.1 2.6 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5392) MACPF PF01823.19 EFC41838.1 - 1e-12 48.6 8.6 3.2e-12 47.0 8.6 1.8 1 1 0 1 1 1 1 MAC/Perforin domain Thioredoxin_15 PF18403.1 EFC41838.1 - 0.038 13.9 0.3 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin-like domain APOBEC4_like PF18774.1 EFC41838.1 - 0.061 13.3 0.3 0.2 11.6 0.3 1.9 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Actin PF00022.19 EFC41839.1 - 7e-27 94.1 0.1 1.9e-24 86.1 0.1 2.0 1 1 0 1 1 1 1 Actin Yae1_N PF09811.9 EFC41840.1 - 0.019 14.7 5.4 0.042 13.5 5.4 1.6 1 1 0 1 1 1 0 Essential protein Yae1, N terminal DUF5308 PF17233.2 EFC41841.1 - 0.11 12.7 0.9 11 6.2 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) DP PF08781.10 EFC41842.1 - 2e-31 108.7 8.1 2e-31 108.7 8.1 1.9 2 0 0 2 2 2 1 Transcription factor DP E2F_TDP PF02319.20 EFC41842.1 - 2.9e-23 81.7 0.5 2.9e-23 81.7 0.5 2.2 3 0 0 3 3 3 1 E2F/DP family winged-helix DNA-binding domain RNA_polI_A34 PF08208.11 EFC41842.1 - 0.013 15.6 12.5 0.013 15.6 12.5 2.3 3 0 0 3 3 3 0 DNA-directed RNA polymerase I subunit RPA34.5 MerR-DNA-bind PF09278.11 EFC41842.1 - 0.13 12.8 1.6 0.28 11.7 1.6 1.5 1 0 0 1 1 1 0 MerR, DNA binding PARP PF00644.20 EFC41843.1 - 4.5e-12 46.0 0.0 9.5e-12 44.9 0.0 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Ank_4 PF13637.6 EFC41843.1 - 1.1e-09 38.6 0.0 1.4e-08 35.1 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC41843.1 - 0.00011 22.7 0.0 0.00028 21.4 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC41843.1 - 0.00035 20.8 0.3 0.0093 16.4 0.0 3.2 4 0 0 4 4 4 1 Ankyrin repeat CUE PF02845.16 EFC41843.1 - 0.00046 19.8 0.0 0.0015 18.2 0.0 2.0 1 0 0 1 1 1 1 CUE domain TIG PF01833.24 EFC41843.1 - 0.0061 16.6 0.1 0.0061 16.6 0.1 2.5 2 0 0 2 2 2 1 IPT/TIG domain Ank_5 PF13857.6 EFC41843.1 - 0.016 15.5 0.0 1.6 9.1 0.0 3.3 2 1 1 3 3 3 0 Ankyrin repeats (many copies) DUF4520 PF15016.6 EFC41843.1 - 0.081 13.0 0.1 24 5.1 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4520) Pkinase PF00069.25 EFC41844.1 - 9.8e-31 107.1 0.6 9.8e-31 107.1 0.6 3.6 3 2 1 4 4 4 1 Protein kinase domain Ank_2 PF12796.7 EFC41844.1 - 2.1e-21 76.3 0.4 9e-13 48.6 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Pkinase_Tyr PF07714.17 EFC41844.1 - 1.1e-19 70.8 0.0 3.3e-19 69.2 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFC41844.1 - 3.2e-16 57.8 0.6 0.00046 20.4 0.0 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 EFC41844.1 - 3.3e-15 56.0 0.2 0.00012 22.3 0.0 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC41844.1 - 1.2e-13 50.8 2.2 0.0026 18.1 0.1 4.0 3 1 1 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFC41844.1 - 2.8e-13 50.1 0.2 3.3e-07 30.7 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Kdo PF06293.14 EFC41844.1 - 0.0033 16.8 0.1 0.0033 16.8 0.1 2.5 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family EIF_2_alpha PF07541.12 EFC41844.1 - 1.3 9.1 10.5 2.5 8.2 3.6 3.4 2 1 1 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit PARP PF00644.20 EFC41845.1 - 2.3e-28 99.1 2.9 9.5e-28 97.1 2.9 1.9 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain FAM24 PF15193.6 EFC41845.1 - 0.055 14.2 0.0 0.15 12.8 0.0 1.8 1 0 0 1 1 1 0 FAM24 family SMAP PF15477.6 EFC41846.1 - 0.046 14.7 1.0 0.061 14.3 0.1 1.7 2 0 0 2 2 2 0 Small acidic protein family L_lactis_RepB_C PF06430.12 EFC41846.1 - 0.05 13.6 3.8 0.16 12.0 3.8 1.7 1 1 0 1 1 1 0 Lactococcus lactis RepB C-terminus Proho_convert PF12177.8 EFC41846.1 - 0.068 13.2 3.0 0.07 13.1 1.3 2.0 2 1 0 2 2 2 0 Prohormone convertase enzyme Ribonucleas_3_3 PF14622.6 EFC41847.1 - 7.5e-22 77.9 0.1 2.7e-12 47.0 0.0 2.6 2 0 0 2 2 2 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EFC41847.1 - 7.7e-15 55.4 1.9 3e-07 31.0 0.3 4.1 3 2 0 3 3 3 2 Ribonuclease III domain dsrm PF00035.26 EFC41847.1 - 0.0022 18.6 0.2 0.0057 17.3 0.2 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif Astro_capsid_N PF03115.14 EFC41848.1 - 0.094 11.4 5.8 0.15 10.7 5.8 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Dynamin_N PF00350.23 EFC41850.1 - 3.2e-10 40.3 2.2 5.4e-10 39.6 0.0 2.5 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFC41850.1 - 0.00016 21.7 1.2 0.0043 17.1 0.1 3.6 3 1 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC41850.1 - 0.0028 17.6 0.1 0.0028 17.6 0.1 2.4 3 0 0 3 3 3 1 RsgA GTPase ABC_tran PF00005.27 EFC41850.1 - 0.074 13.6 0.0 0.41 11.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter CdiI_N PF18228.1 EFC41851.1 - 0.028 14.3 0.2 0.12 12.2 0.0 2.2 2 1 0 2 2 2 0 CdiI N-terminal domain DUF4209 PF13910.6 EFC41852.1 - 6.1e-24 84.1 0.2 6.6e-23 80.8 0.0 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4209) ESAG1 PF03238.13 EFC41852.1 - 0.017 14.6 0.3 0.04 13.4 0.3 1.5 1 0 0 1 1 1 0 ESAG protein Prefoldin PF02996.17 EFC41853.1 - 1e-24 86.8 1.1 1.3e-24 86.4 1.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 EFC41853.1 - 0.0084 16.1 0.1 0.015 15.3 0.1 1.5 1 1 0 1 1 1 1 Prefoldin subunit ABC_tran_Xtn PF12848.7 EFC41853.1 - 0.014 15.4 7.1 4.1 7.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter Prefoldin_2 PF01920.20 EFC41853.1 - 0.019 14.9 0.8 0.019 14.9 0.8 2.8 2 1 0 2 2 2 0 Prefoldin subunit ApoO PF09769.9 EFC41853.1 - 0.029 14.3 5.3 0.11 12.5 0.6 2.3 1 1 0 2 2 2 0 Apolipoprotein O DASH_Duo1 PF08651.10 EFC41853.1 - 0.074 12.8 4.2 1.2 8.9 0.7 2.2 2 0 0 2 2 2 0 DASH complex subunit Duo1 FlaC_arch PF05377.11 EFC41853.1 - 0.93 9.9 3.7 13 6.3 0.3 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Atg14 PF10186.9 EFC41853.1 - 1.5 7.8 11.5 2.6 7.0 4.3 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 COG2 PF06148.11 EFC41853.1 - 3.1 7.9 8.2 5.4 7.1 3.7 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF5340 PF17275.2 EFC41853.1 - 8 6.7 11.6 1.2 9.4 4.7 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5340) MIS13 PF08202.11 EFC41854.1 - 0.012 14.9 1.5 0.012 14.9 0.3 1.5 2 0 0 2 2 2 0 Mis12-Mtw1 protein family HrpF PF06266.12 EFC41854.1 - 0.048 14.0 2.1 0.059 13.7 0.3 2.0 2 0 0 2 2 2 0 HrpF protein Stomoxyn PF11585.8 EFC41854.1 - 0.68 10.0 5.0 0.19 11.7 0.8 2.2 2 0 0 2 2 2 0 Insect antimicrobial peptide, stomoxyn Phage_integrase PF00589.22 EFC41855.1 - 3.1e-06 27.1 0.0 4.9e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family DUF2666 PF10869.8 EFC41855.1 - 0.011 16.0 0.2 0.098 12.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) PHR PF08005.12 EFC41855.1 - 0.059 14.1 0.1 0.32 11.6 0.0 2.1 2 0 0 2 2 2 0 PHR domain DUF4020 PF13212.6 EFC41857.1 - 0.056 13.3 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4020) DUF2935 PF11155.8 EFC41857.1 - 0.061 13.7 1.4 0.17 12.2 0.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) Ammonium_transp PF00909.21 EFC41858.1 - 4.7e-37 127.6 35.6 4.7e-37 127.6 35.6 2.1 2 1 0 2 2 2 1 Ammonium Transporter Family Cofilin_ADF PF00241.20 EFC41858.1 - 3.2e-06 26.9 0.2 3.2e-06 26.9 0.2 2.2 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein Corona_M PF01635.18 EFC41858.1 - 0.016 14.6 0.5 0.016 14.6 0.5 2.1 2 0 0 2 2 2 0 Coronavirus M matrix/glycoprotein Baculo_PEP_C PF04513.12 EFC41858.1 - 0.33 11.0 4.6 0.71 9.9 4.6 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5401 PF17380.2 EFC41858.1 - 4.4 5.2 75.3 7 4.6 75.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF2192 PF09958.9 EFC41859.1 - 0.0071 15.9 3.0 0.019 14.5 2.9 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2192) NHL PF01436.21 EFC41861.1 - 4.7e-10 39.0 0.0 0.0059 16.6 0.0 5.4 5 0 0 5 5 5 2 NHL repeat SdiA-regulated PF06977.11 EFC41861.1 - 0.001 18.4 0.1 0.031 13.5 0.0 2.7 2 1 1 3 3 3 1 SdiA-regulated DUF4825 PF16107.5 EFC41861.1 - 0.024 14.7 0.0 0.056 13.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) Il2rg PF15874.5 EFC41861.1 - 0.071 13.4 0.1 5.4 7.3 0.0 2.8 2 1 0 2 2 2 0 Putative Interleukin 2 receptor, gamma chain SGL PF08450.12 EFC41861.1 - 0.11 12.1 0.0 0.55 9.8 0.0 2.1 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region LRR_8 PF13855.6 EFC41862.1 - 7.4e-28 96.1 35.5 2.4e-09 36.8 1.6 4.5 2 2 3 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 EFC41862.1 - 6.5e-27 91.3 20.9 0.001 19.0 0.2 9.5 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC41862.1 - 9.6e-19 67.2 24.5 0.00021 21.6 0.7 6.0 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41862.1 - 2.9e-11 42.3 13.6 4.1 8.3 0.3 8.2 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC41862.1 - 1.2e-07 31.4 8.5 0.0003 20.3 4.8 3.3 1 1 2 3 3 3 3 Leucine-rich repeat DUF2806 PF10987.8 EFC41862.1 - 0.0036 17.2 3.7 0.0054 16.6 3.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2806) UMPH-1 PF05822.12 EFC41862.1 - 0.01 15.3 0.1 0.015 14.8 0.1 1.3 1 0 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) Cluap1 PF10234.9 EFC41862.1 - 0.013 14.9 1.7 0.018 14.4 1.7 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF758 PF05527.11 EFC41862.1 - 0.19 11.7 3.8 1.5 8.8 1.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF758) DUF424 PF04242.13 EFC41862.1 - 0.35 11.1 4.6 36 4.7 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF424) Phe_tRNA-synt_N PF02912.18 EFC41863.1 - 0.062 13.2 0.0 0.79 9.7 0.0 2.2 2 0 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain Calreticulin PF00262.18 EFC41864.1 - 6.9e-147 489.1 18.3 1.1e-146 488.5 18.3 1.3 1 0 0 1 1 1 1 Calreticulin family Amino_oxidase PF01593.24 EFC41864.1 - 1e-11 44.8 0.0 2.2e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC41864.1 - 2.7e-11 43.5 1.2 5.5e-11 42.5 1.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFC41864.1 - 2.6e-08 33.4 2.5 7e-06 25.4 3.5 2.3 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 EFC41864.1 - 1.5e-07 31.4 0.4 0.00015 21.5 1.5 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 EFC41864.1 - 3e-07 29.9 1.7 6.3e-07 28.9 0.4 2.0 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 EFC41864.1 - 3.6e-06 26.0 10.0 0.0011 17.8 1.2 2.7 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_3 PF01494.19 EFC41864.1 - 3.6e-05 23.2 1.4 6.4e-05 22.4 1.4 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 EFC41864.1 - 0.00025 20.5 2.1 0.022 14.1 2.3 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC41864.1 - 0.0037 16.5 1.7 0.0044 16.3 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC41864.1 - 0.027 13.7 4.9 0.16 11.2 2.4 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SID-1_RNA_chan PF13965.6 EFC41864.1 - 0.032 12.7 1.1 0.051 12.0 1.1 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GIDA PF01134.22 EFC41864.1 - 0.035 13.2 4.0 2.1 7.3 1.4 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A GDI PF00996.18 EFC41864.1 - 0.037 12.5 1.0 0.66 8.4 0.2 2.2 2 0 0 2 2 2 0 GDP dissociation inhibitor Pyr_redox PF00070.27 EFC41864.1 - 0.26 11.9 5.8 1.3 9.7 0.9 2.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UDPGT PF00201.18 EFC41865.1 - 6.6e-18 64.8 0.0 1.9e-17 63.3 0.0 1.7 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFC41865.1 - 0.011 15.8 0.0 0.036 14.1 0.0 1.9 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain Enkurin PF13864.6 EFC41866.1 - 0.033 14.6 0.1 0.057 13.8 0.1 1.3 1 0 0 1 1 1 0 Calmodulin-binding CitMHS PF03600.16 EFC41867.1 - 4.7e-38 131.1 11.8 1.6e-27 96.5 0.0 2.4 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 EFC41867.1 - 1.5e-10 40.7 48.5 2.9e-08 33.2 22.1 3.2 3 0 0 3 3 3 3 Sodium:sulfate symporter transmembrane region TrkA_C PF02080.21 EFC41867.1 - 0.00044 20.0 0.0 0.79 9.6 0.0 2.5 2 0 0 2 2 2 2 TrkA-C domain NHL PF01436.21 EFC41868.1 - 1.3e-23 81.8 0.0 0.00025 20.9 0.0 6.0 5 0 0 5 5 5 5 NHL repeat EGF_2 PF07974.13 EFC41868.1 - 1.9e-15 56.9 63.0 5.5e-05 23.4 9.5 4.5 4 0 0 4 4 4 4 EGF-like domain SGL PF08450.12 EFC41868.1 - 0.0019 17.9 0.0 2.1 7.9 0.0 4.1 2 1 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC41868.1 - 0.0041 17.3 0.0 0.037 14.2 0.0 2.4 3 0 0 3 3 3 1 Arylesterase EGF PF00008.27 EFC41868.1 - 0.013 15.8 16.4 0.022 15.0 6.2 4.7 4 0 0 4 4 4 0 EGF-like domain TMEM18 PF14770.6 EFC41868.1 - 0.064 13.3 0.0 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 18 Sel1 PF08238.12 EFC41869.1 - 1.8e-73 241.3 33.1 1.8e-09 38.0 0.3 10.3 9 1 1 10 10 10 10 Sel1 repeat TPR_7 PF13176.6 EFC41869.1 - 0.00025 20.8 1.2 0.3 11.2 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC41869.1 - 0.0039 17.8 0.6 1.3 9.7 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41869.1 - 0.005 16.5 0.2 0.005 16.5 0.2 5.3 5 1 0 5 5 5 1 TPR repeat TPR_12 PF13424.6 EFC41869.1 - 0.0095 16.2 7.8 0.05 13.9 0.0 5.1 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC41869.1 - 0.018 15.1 23.9 0.027 14.6 0.1 7.9 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41869.1 - 0.019 14.8 0.2 0.019 14.8 0.2 8.1 11 0 0 11 11 11 0 Tetratricopeptide repeat FCH PF00611.23 EFC41869.1 - 0.046 14.0 3.1 1.5 9.1 0.0 4.2 4 1 1 5 5 4 0 Fes/CIP4, and EFC/F-BAR homology domain tRNA_synt_1c_R2 PF04557.15 EFC41869.1 - 0.18 12.8 4.3 0.46 11.4 4.3 1.7 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 ANAPC3 PF12895.7 EFC41869.1 - 0.76 10.1 13.3 1.4 9.2 0.2 4.6 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Ta0938 PF11494.8 EFC41869.1 - 9.3 6.6 7.0 12 6.2 0.1 4.0 3 2 2 5 5 5 0 Ta0938 Inositol_P PF00459.25 EFC41871.1 - 7.4e-60 202.8 0.1 9e-60 202.5 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family AIRS PF00586.24 EFC41872.1 - 1.1e-19 70.8 1.5 8.9e-19 68.0 0.1 2.8 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 EFC41872.1 - 1.1e-18 67.9 0.0 2.4e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain Methyltransf_31 PF13847.6 EFC41872.1 - 0.00091 19.0 0.0 0.0035 17.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Herpes_capsid PF06112.11 EFC41872.1 - 0.28 11.2 12.2 0.57 10.2 12.2 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Glyco_hydro_19 PF00182.19 EFC41873.1 - 3.8e-14 53.1 0.1 1.4e-13 51.3 0.1 1.9 1 1 0 1 1 1 1 Chitinase class I Zn_clus PF00172.18 EFC41874.1 - 4.6e-10 39.5 11.1 7.4e-10 38.8 11.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAM_1 PF00536.30 EFC41874.1 - 1.6e-06 28.5 0.1 2.6e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC41874.1 - 1.7e-05 24.8 0.1 3.4e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RNase_Zc3h12a PF11977.8 EFC41875.1 - 0.04 13.7 1.4 0.088 12.6 1.2 1.6 1 1 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain MINDY_DUB PF04424.13 EFC41876.1 - 6.4e-21 74.5 0.1 6.4e-21 74.5 0.1 2.0 2 0 0 2 2 2 1 MINDY deubiquitinase DUF4150 PF13665.6 EFC41876.1 - 0.014 15.6 0.1 0.032 14.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4150) DUF1481 PF07356.12 EFC41876.1 - 0.46 10.2 12.5 0.12 12.1 8.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1481) Clathrin_propel PF01394.20 EFC41877.1 - 0.48 10.8 1.9 34 5.0 0.0 4.0 4 0 0 4 4 4 0 Clathrin propeller repeat Ras PF00071.22 EFC41878.1 - 5.6e-34 117.1 0.2 8.4e-34 116.5 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41878.1 - 7.1e-17 61.7 0.0 1.3e-16 60.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41878.1 - 1e-08 34.8 0.2 2.5e-08 33.5 0.2 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC41878.1 - 3.8e-08 33.1 0.7 8.9e-07 28.6 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC41878.1 - 0.0024 17.8 1.5 0.024 14.5 0.3 2.2 2 0 0 2 2 2 1 RsgA GTPase F-box PF00646.33 EFC41878.1 - 0.0093 15.8 0.1 0.023 14.6 0.1 1.7 1 0 0 1 1 1 1 F-box domain MMR_HSR1 PF01926.23 EFC41878.1 - 0.017 15.2 0.0 0.041 14.0 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box-like PF12937.7 EFC41878.1 - 0.064 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 F-box-like PRANC PF09372.10 EFC41878.1 - 0.25 11.7 0.0 0.25 11.7 0.0 3.7 4 0 0 4 4 4 0 PRANC domain RhoGAP PF00620.27 EFC41879.1 - 8.4e-30 103.6 0.6 2.9e-29 101.9 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain DUF3135 PF11333.8 EFC41879.1 - 0.096 12.9 0.1 0.31 11.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3135) RNA_pol_L_2 PF13656.6 EFC41880.1 - 7.4e-26 89.7 0.2 1.1e-25 89.2 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFC41880.1 - 5e-07 29.1 0.0 8.5e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LRR_6 PF13516.6 EFC41881.1 - 2.9e-19 67.4 16.6 0.0039 17.1 0.0 6.7 6 0 0 6 6 6 5 Leucine Rich repeat PH PF00169.29 EFC41881.1 - 1e-16 61.4 0.6 4.5e-14 52.8 0.5 2.8 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EFC41881.1 - 1.2e-06 28.9 1.9 3.8e-06 27.3 0.1 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain LRR_4 PF12799.7 EFC41881.1 - 3.2e-06 27.4 20.0 0.0043 17.4 1.8 5.1 3 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41881.1 - 0.038 14.5 10.0 21 6.2 0.1 6.2 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC41881.1 - 0.75 9.6 20.4 0.19 11.5 1.9 4.9 4 1 1 5 5 5 0 Leucine rich repeat Abhydrolase_3 PF07859.13 EFC41882.1 - 2.8e-14 53.5 0.0 3.8e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC41882.1 - 1.9e-11 43.4 0.1 1.7e-10 40.3 0.1 2.2 1 1 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S10 PF00450.22 EFC41882.1 - 0.00022 20.8 0.0 0.00034 20.1 0.0 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase Abhydrolase_1 PF00561.20 EFC41882.1 - 0.0058 16.3 0.0 0.0093 15.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC41882.1 - 0.01 15.1 0.0 0.016 14.5 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF3169 PF11368.8 EFC41882.1 - 0.7 9.4 3.1 1.1 8.7 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) GST_C_3 PF14497.6 EFC41883.1 - 2.1e-10 40.6 0.1 4.2e-10 39.7 0.1 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC41883.1 - 5.8e-05 23.4 0.0 0.00016 22.0 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC41883.1 - 0.0066 16.6 0.1 0.011 15.9 0.1 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Hydrolase_4 PF12146.8 EFC41884.1 - 0.00029 20.2 0.0 0.00054 19.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC41884.1 - 0.00037 21.2 0.0 0.00055 20.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC41884.1 - 0.016 14.8 0.0 0.039 13.6 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Calcyon PF06387.11 EFC41884.1 - 0.13 12.2 0.1 2.4 8.1 0.0 2.3 2 0 0 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) RRM_1 PF00076.22 EFC41885.1 - 2.2e-21 75.4 0.0 8.9e-10 38.3 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFC41885.1 - 1.6e-09 37.6 0.0 6.2e-07 29.3 0.0 2.7 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 EFC41885.1 - 1.4e-07 31.5 0.8 0.016 15.2 0.0 3.4 2 1 1 3 3 3 2 RNA binding motif RRM_5 PF13893.6 EFC41885.1 - 3.6e-07 29.8 0.0 0.0095 15.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC41885.1 - 5e-06 26.3 0.0 0.032 14.1 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif PWI PF01480.17 EFC41885.1 - 0.00047 20.4 0.7 0.0018 18.5 0.0 2.2 2 0 0 2 2 2 1 PWI domain DUF3446 PF11928.8 EFC41885.1 - 0.0028 17.9 4.8 0.0028 17.9 4.8 2.2 2 0 0 2 2 2 1 Early growth response N-terminal domain RNA_bind PF08675.11 EFC41885.1 - 0.0045 17.0 0.0 1.7 8.7 0.0 2.6 2 0 0 2 2 2 1 RNA binding domain NCBP3 PF10309.9 EFC41885.1 - 0.0065 16.3 0.0 0.37 10.7 0.0 2.6 2 0 0 2 2 2 1 Nuclear cap-binding protein subunit 3 DUF4283 PF14111.6 EFC41885.1 - 0.0081 15.7 0.1 0.048 13.2 0.0 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4283) PHM7_cyt PF14703.6 EFC41885.1 - 0.28 11.4 0.0 0.28 11.4 0.0 5.1 3 2 3 6 6 6 0 Cytosolic domain of 10TM putative phosphate transporter Arm PF00514.23 EFC41886.1 - 6e-58 191.3 14.6 2.9e-10 39.8 0.5 10.0 10 0 0 10 10 10 7 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 EFC41886.1 - 3.5e-13 49.6 13.5 0.0019 17.7 0.3 5.2 1 1 4 5 5 5 5 Armadillo-like KAP PF05804.12 EFC41886.1 - 4.4e-12 45.0 8.4 1.4e-06 26.8 0.5 2.3 1 1 1 2 2 2 2 Kinesin-associated protein (KAP) HEAT_2 PF13646.6 EFC41886.1 - 3.1e-09 37.1 0.0 0.023 15.1 0.0 5.0 1 1 5 6 6 6 4 HEAT repeats Atx10homo_assoc PF09759.9 EFC41886.1 - 1.2e-06 28.4 12.8 0.00065 19.7 1.3 5.2 1 1 1 5 5 5 2 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 EFC41886.1 - 3.9e-06 27.2 0.0 1.5 9.4 0.0 5.0 4 0 0 4 4 4 1 HEAT-like repeat HEAT PF02985.22 EFC41886.1 - 9.5e-06 25.4 1.3 0.25 11.7 0.0 5.8 7 0 0 7 7 7 1 HEAT repeat Cnd1 PF12717.7 EFC41886.1 - 1.4e-05 25.2 6.0 0.49 10.4 0.2 5.0 1 1 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 EFC41886.1 - 0.0015 18.7 6.8 0.99 9.5 0.0 4.9 2 1 3 6 6 6 3 V-ATPase subunit H Ribosomal_L34e PF01199.18 EFC41887.1 - 1.5e-28 98.9 2.7 1.5e-28 98.9 2.7 1.4 2 0 0 2 2 2 1 Ribosomal protein L34e MA3 PF02847.17 EFC41888.1 - 4.8e-21 74.9 0.2 4.8e-21 74.9 0.2 3.5 4 0 0 4 4 4 1 MA3 domain MIF4G PF02854.19 EFC41888.1 - 2.2e-16 60.1 14.1 2.8e-16 59.8 6.8 2.9 2 1 0 2 2 2 2 MIF4G domain CDV3 PF15359.6 EFC41888.1 - 0.082 13.4 0.1 0.082 13.4 0.1 3.2 3 0 0 3 3 3 0 Carnitine deficiency-associated protein 3 Alpha-mann_mid PF09261.11 EFC41888.1 - 0.87 9.8 0.0 0.87 9.8 0.0 2.9 3 0 0 3 3 3 0 Alpha mannosidase middle domain Pkinase PF00069.25 EFC41889.1 - 8.6e-63 212.2 0.2 8.6e-63 212.2 0.2 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC41889.1 - 2.8e-44 151.4 0.0 2.8e-44 151.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC41889.1 - 4.1e-05 23.1 0.0 8.7e-05 22.0 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC41889.1 - 0.011 14.6 3.0 0.011 14.6 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase MYCBPAP PF14646.6 EFC41890.1 - 3.3e-32 112.0 2.9 7.4e-30 104.3 2.9 2.4 1 1 0 1 1 1 1 MYCBP-associated protein family ADH_zinc_N PF00107.26 EFC41891.1 - 4e-11 43.0 0.0 1.9e-10 40.8 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC41891.1 - 9.8e-05 23.4 0.0 0.00031 21.8 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DapB_N PF01113.20 EFC41891.1 - 0.0046 17.1 0.1 0.0095 16.1 0.1 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus ADH_N PF08240.12 EFC41891.1 - 0.014 15.3 0.6 0.12 12.3 0.1 2.5 2 1 1 3 3 3 0 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 EFC41891.1 - 0.066 13.5 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Beach PF02138.18 EFC41892.1 - 4.6e-48 164.0 1.0 4.6e-48 164.0 1.0 2.8 3 0 0 3 3 3 1 Beige/BEACH domain Pkinase PF00069.25 EFC41892.1 - 2.5e-16 59.9 3.2 3.2e-10 39.8 0.6 3.1 3 0 0 3 3 3 2 Protein kinase domain ANAPC4_WD40 PF12894.7 EFC41892.1 - 0.0033 17.7 0.0 7.9 6.9 0.0 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Musclin PF11037.8 EFC41892.1 - 0.0052 16.7 0.3 0.014 15.3 0.3 1.7 1 0 0 1 1 1 1 Insulin-resistance promoting peptide in skeletal muscle Sel1 PF08238.12 EFC41893.1 - 5.2e-25 87.3 2.0 1.5e-08 35.1 0.0 5.6 5 1 0 5 5 5 5 Sel1 repeat TPR_8 PF13181.6 EFC41893.1 - 0.02 15.1 0.4 3.9 7.9 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41893.1 - 0.021 14.7 0.7 3.2 7.7 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC41893.1 - 0.088 13.0 4.9 6.7 7.1 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41893.1 - 0.091 13.1 0.3 26 5.2 0.0 3.2 4 1 0 4 4 4 0 Tetratricopeptide repeat DUF4116 PF13475.6 EFC41896.1 - 1.1e-51 172.4 14.5 2.3e-14 52.8 0.0 8.8 5 3 3 9 9 9 7 Domain of unknown function (DUF4116) PPTA PF01239.22 EFC41896.1 - 0.036 13.8 0.1 0.35 10.7 0.0 2.9 4 0 0 4 4 4 0 Protein prenyltransferase alpha subunit repeat LcrR PF09621.10 EFC41896.1 - 0.13 11.7 0.0 0.55 9.7 0.0 1.9 1 1 1 2 2 2 0 Type III secretion system regulator (LcrR) Pkinase_Tyr PF07714.17 EFC41897.1 - 1.2e-52 178.7 0.0 3.8e-51 173.9 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC41897.1 - 1.9e-51 175.0 0.0 3.9e-51 173.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Chlam_PMP PF02415.17 EFC41897.1 - 9.7e-05 22.6 5.5 0.33 11.5 0.0 5.0 3 0 0 3 3 3 2 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pkinase_fungal PF17667.1 EFC41897.1 - 0.0028 16.5 0.0 0.0043 15.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC41897.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LMBR1 PF04791.16 EFC41898.1 - 2.4e-66 224.7 9.9 2.4e-66 224.7 9.9 1.6 2 0 0 2 2 2 1 LMBR1-like membrane protein LapA_dom PF06305.11 EFC41898.1 - 0.07 13.0 0.1 0.07 13.0 0.1 4.2 2 1 1 4 4 4 0 Lipopolysaccharide assembly protein A domain Bac_export_2 PF01312.19 EFC41898.1 - 0.31 10.2 5.5 0.32 10.2 0.0 2.3 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family DUF4957 PF16318.5 EFC41899.1 - 0.0017 18.3 16.5 0.044 13.7 3.3 4.3 1 1 1 3 3 3 2 Domain of unknown function (DUF4957) Herpes_gE PF02480.16 EFC41899.1 - 0.018 13.8 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF2149 PF09919.9 EFC41899.1 - 0.044 14.0 0.1 0.21 11.8 0.1 2.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) GAF_2 PF13185.6 EFC41900.1 - 5.4e-07 30.0 0.0 7.4e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 EFC41900.1 - 2.7e-06 28.0 0.0 3.4e-06 27.7 0.0 1.3 1 1 0 1 1 1 1 GAF domain DUF2688 PF10892.8 EFC41900.1 - 0.15 11.6 0.8 0.28 10.7 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2688) Ras PF00071.22 EFC41901.1 - 2.6e-37 127.9 2.5 2.6e-23 82.4 0.8 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC41901.1 - 4.6e-17 62.3 0.1 8.7e-11 42.1 0.1 2.9 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ank_2 PF12796.7 EFC41901.1 - 4e-09 36.9 0.4 4.9e-08 33.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC41901.1 - 1e-08 35.2 0.2 0.0024 18.2 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 EFC41901.1 - 3.1e-08 33.2 1.7 0.014 15.9 0.0 3.5 3 0 0 3 3 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC41901.1 - 8.9e-08 32.5 0.1 3e-07 30.9 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Arf PF00025.21 EFC41901.1 - 1.4e-07 31.2 8.1 4.9e-06 26.1 0.4 3.4 3 1 1 4 4 4 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC41901.1 - 5e-06 26.6 0.1 0.058 13.5 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase Ank_5 PF13857.6 EFC41901.1 - 7.5e-06 26.1 0.1 2.8e-05 24.3 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) AAA_7 PF12775.7 EFC41901.1 - 0.032 13.8 0.0 0.26 10.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 EFC41901.1 - 0.043 14.2 0.0 5.4 7.4 0.0 3.3 4 0 0 4 4 4 0 AAA ATPase domain RWP-RK PF02042.15 EFC41902.1 - 4.7e-09 36.1 0.0 1.7e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 RWP-RK domain HTH_Tnp_ISL3 PF13542.6 EFC41902.1 - 0.13 11.7 0.0 0.27 10.7 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Macoilin PF09726.9 EFC41902.1 - 0.19 10.3 17.2 0.22 10.0 17.2 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 EFC41902.1 - 0.84 6.7 17.5 1 6.4 17.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SPX PF03105.19 EFC41902.1 - 8.2 6.2 22.1 9.3 6.0 21.3 1.5 2 0 0 2 2 2 0 SPX domain Cnn_1N PF07989.11 EFC41903.1 - 0.015 15.4 13.5 0.015 15.4 13.5 4.2 2 1 2 4 4 4 0 Centrosomin N-terminal motif 1 DUF4530 PF15039.6 EFC41903.1 - 0.16 12.1 3.4 0.23 11.6 1.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4530) HisKA_2 PF07568.12 EFC41903.1 - 0.22 11.6 3.8 0.25 11.4 0.9 2.7 2 1 1 3 3 3 0 Histidine kinase Hrs_helical PF12210.8 EFC41903.1 - 0.34 11.5 14.7 21 5.7 1.8 3.8 2 1 1 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate ALMT PF11744.8 EFC41903.1 - 1.3 7.8 20.4 2.2 7.0 20.4 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4472 PF14739.6 EFC41903.1 - 5.2 7.8 29.2 1.1 10.0 17.4 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4472) DUF3450 PF11932.8 EFC41903.1 - 5.9 6.1 20.6 0.59 9.4 6.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DCP2 PF05026.13 EFC41904.1 - 3.6e-26 91.3 4.2 2.5e-25 88.6 2.3 2.6 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 EFC41904.1 - 1.8e-13 50.7 0.0 3.2e-13 49.9 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 EFC41904.1 - 0.019 14.5 0.0 0.05 13.2 0.0 1.7 1 1 0 1 1 1 0 Nucleotide hydrolase DUF4116 PF13475.6 EFC41905.1 - 5.8e-137 445.4 37.7 2e-17 62.7 0.0 12.3 4 1 9 15 15 15 14 Domain of unknown function (DUF4116) YafO_toxin PF13957.6 EFC41905.1 - 0.0097 15.9 0.0 0.75 9.9 0.0 3.0 2 0 0 2 2 2 1 Toxin YafO, type II toxin-antitoxin system DUF1667 PF07892.11 EFC41905.1 - 0.016 15.2 0.0 12 6.0 0.0 4.3 3 1 0 4 4 4 0 Protein of unknown function (DUF1667) 6PF2K PF01591.18 EFC41905.1 - 0.055 12.8 2.3 0.44 9.8 0.1 3.0 3 0 0 3 3 3 0 6-phosphofructo-2-kinase PPL4 PF18188.1 EFC41906.1 - 5.5e-57 192.1 0.6 7.3e-57 191.8 0.6 1.2 1 0 0 1 1 1 1 Prim-pol 4 PEGA PF08308.11 EFC41906.1 - 0.16 11.9 0.5 5.2 7.0 0.1 2.8 3 0 0 3 3 3 0 PEGA domain Pkinase PF00069.25 EFC41907.1 - 4.6e-15 55.7 2.9 4.6e-15 55.7 2.9 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC41907.1 - 2.8e-05 23.1 0.0 4.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 EFC41907.1 - 6.9e-05 22.3 0.9 0.00023 20.5 0.9 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFC41907.1 - 0.0015 18.1 0.6 0.0034 17.0 0.2 1.7 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 EFC41907.1 - 0.1 12.5 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Herpes_IE1 PF07340.11 EFC41908.1 - 0.04 12.9 0.0 0.051 12.5 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus IE1 protein FAM199X PF15814.5 EFC41909.1 - 0.011 14.9 4.2 0.018 14.1 4.2 1.3 1 0 0 1 1 1 0 Protein family FAM199X PPL4 PF18188.1 EFC41911.1 - 1.3e-61 207.2 3.7 1.8e-61 206.8 3.7 1.2 1 0 0 1 1 1 1 Prim-pol 4 zf-MYND PF01753.18 EFC41912.1 - 2.9e-08 33.6 12.5 8.4e-08 32.2 12.5 1.9 1 0 0 1 1 1 1 MYND finger FKBP_C PF00254.28 EFC41912.1 - 9.7e-08 32.2 0.1 0.0043 17.3 0.0 2.7 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase FAT PF02259.23 EFC41913.1 - 7.5e-90 301.6 11.2 7.5e-90 301.6 11.2 2.5 2 1 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 EFC41913.1 - 8.9e-78 261.6 0.3 2.5e-77 260.1 0.3 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 EFC41913.1 - 2.6e-63 212.8 9.2 5.7e-57 192.1 0.2 6.1 4 1 1 5 5 5 3 Domain of unknown function (DUF3385) FRB_dom PF08771.11 EFC41913.1 - 1.9e-42 143.7 0.2 1.9e-42 143.7 0.2 3.7 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 EFC41913.1 - 2.6e-17 63.0 0.0 0.0004 20.7 0.0 9.5 8 1 4 12 12 11 4 HEAT repeats HEAT_EZ PF13513.6 EFC41913.1 - 3.7e-17 62.4 1.8 0.079 13.5 0.0 9.1 8 1 1 9 9 7 4 HEAT-like repeat HEAT PF02985.22 EFC41913.1 - 4.7e-17 60.6 12.4 0.048 13.9 0.0 13.2 14 0 0 14 14 13 4 HEAT repeat FATC PF02260.20 EFC41913.1 - 1.7e-15 56.5 1.6 4.2e-15 55.3 1.6 1.7 1 0 0 1 1 1 1 FATC domain Cnd1 PF12717.7 EFC41913.1 - 5.1e-06 26.6 6.8 0.046 13.8 0.0 6.4 6 2 1 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFC41913.1 - 7.4e-06 26.5 6.0 0.63 10.7 0.0 7.6 9 2 1 10 10 7 1 Vacuolar 14 Fab1-binding region UME PF08064.13 EFC41913.1 - 0.00067 19.5 4.7 0.58 10.1 0.2 5.5 4 1 1 5 5 5 1 UME (NUC010) domain Arm PF00514.23 EFC41913.1 - 0.05 13.7 0.0 34 4.7 0.0 4.5 5 0 0 5 5 4 0 Armadillo/beta-catenin-like repeat DUF2603 PF10788.9 EFC41913.1 - 0.06 13.4 1.2 3.2 7.8 0.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2603) Sec7_N PF12783.7 EFC41913.1 - 0.072 13.0 4.1 6.9 6.6 0.0 4.1 4 0 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal PseudoU_synth_2 PF00849.22 EFC41914.1 - 2.3e-18 66.8 0.3 2.3e-18 66.8 0.3 1.8 2 0 0 2 2 2 1 RNA pseudouridylate synthase DUF3185 PF11381.8 EFC41915.1 - 0.0042 17.0 1.9 1.4 9.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3185) DUF308 PF03729.13 EFC41915.1 - 0.0058 16.9 15.9 0.039 14.3 6.5 2.3 1 1 2 3 3 3 2 Short repeat of unknown function (DUF308) DUF4064 PF13273.6 EFC41915.1 - 0.015 15.6 16.4 0.033 14.4 16.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4064) DUF5305 PF17231.2 EFC41915.1 - 0.027 13.9 2.6 0.29 10.5 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5305) Trp_oprn_chp PF09534.10 EFC41915.1 - 0.03 14.1 2.4 1.9 8.3 1.8 2.0 1 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Gram_pos_anchor PF00746.21 EFC41915.1 - 0.21 11.5 5.0 0.57 10.2 1.1 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF3995 PF13160.6 EFC41915.1 - 0.26 11.7 7.7 0.21 12.0 4.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) UPF0182 PF03699.13 EFC41915.1 - 0.44 8.6 6.0 0.44 8.6 6.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF3180 PF11377.8 EFC41915.1 - 0.56 10.3 9.9 3.3 7.9 7.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) DUF3040 PF11239.8 EFC41915.1 - 1.5 9.2 12.5 9.4 6.6 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) SseC PF04888.12 EFC41915.1 - 1.6 8.2 3.7 3.5 7.1 1.8 1.9 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF2207 PF09972.9 EFC41915.1 - 4 6.1 8.7 6.9 5.3 8.7 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) OATP PF03137.20 EFC41915.1 - 4.4 5.5 10.0 15 3.7 10.4 1.6 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PGPGW PF09656.10 EFC41915.1 - 5.2 6.6 9.7 4.7 6.8 2.8 2.5 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) SdpI PF13630.6 EFC41915.1 - 7.9 6.7 17.2 3.4e+03 -1.8 17.2 2.2 1 1 0 1 1 1 0 SdpI/YhfL protein family HSP90 PF00183.18 EFC41917.1 - 4.5e-78 263.4 11.9 6.8e-78 262.8 11.9 1.2 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFC41917.1 - 9.4e-08 32.6 0.0 1.8e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFC41917.1 - 0.01 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1655 PF07868.11 EFC41917.1 - 0.11 12.6 0.1 0.26 11.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1655) cNMP_binding PF00027.29 EFC41918.1 - 2.7e-15 56.2 0.0 5e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 EFC41918.1 - 1.9e-08 33.9 16.0 2.6e-08 33.4 16.0 1.2 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EFC41918.1 - 1.1 9.3 10.2 0.044 13.8 3.9 2.1 2 0 0 2 2 2 0 Ion channel DUF1431 PF07248.12 EFC41919.1 - 0.074 13.3 2.0 0.095 13.0 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1431) Pacs-1 PF10254.9 EFC41919.1 - 0.085 11.8 2.7 4.7 6.1 1.7 2.7 1 1 2 3 3 3 0 PACS-1 cytosolic sorting protein LRR_6 PF13516.6 EFC41920.1 - 2.9e-33 111.1 30.4 0.00096 19.0 0.0 12.4 12 0 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC41920.1 - 1.6e-25 88.6 27.9 5.6e-08 32.4 1.1 5.8 4 1 2 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC41920.1 - 2.2e-22 78.8 39.5 5.6e-05 23.4 0.2 8.5 4 3 3 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41920.1 - 1.7e-06 27.8 23.4 15 6.6 0.0 10.2 9 3 0 9 9 9 3 Leucine Rich Repeat PapC_C PF13953.6 EFC41920.1 - 0.02 14.7 0.0 17 5.3 0.0 3.4 3 0 0 3 3 3 0 PapC C-terminal domain Hydrolase_4 PF12146.8 EFC41921.1 - 1e-11 44.6 0.0 6.1e-07 29.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC41921.1 - 9.4e-07 28.5 0.0 1.8e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 EFC41921.1 - 2.4e-05 24.2 0.0 0.00022 21.1 0.0 2.1 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 EFC41921.1 - 0.00012 21.8 0.0 0.22 11.2 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold DUF818 PF05677.12 EFC41921.1 - 0.0027 16.7 0.0 0.0039 16.2 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.13 EFC41921.1 - 0.08 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) 3HBOH PF10605.9 EFC41921.1 - 0.17 10.1 0.0 0.2 9.8 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) LIP PF03583.14 EFC41921.1 - 0.2 10.9 0.0 2.5 7.4 0.0 2.0 2 0 0 2 2 2 0 Secretory lipase PPR_2 PF13041.6 EFC41923.1 - 1.8e-56 188.2 38.2 5.9e-12 45.6 0.1 13.0 7 4 7 14 14 14 12 PPR repeat family PPR PF01535.20 EFC41923.1 - 7.8e-52 170.0 42.0 5.4e-06 26.3 0.1 15.1 16 0 0 16 16 15 10 PPR repeat PPR_1 PF12854.7 EFC41923.1 - 7.3e-38 128.0 20.6 0.00089 18.9 0.1 12.1 11 1 1 12 12 12 9 PPR repeat DYW_deaminase PF14432.6 EFC41923.1 - 2.2e-33 114.8 2.0 6.7e-33 113.3 2.0 1.9 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases PPR_3 PF13812.6 EFC41923.1 - 8.1e-22 77.1 12.2 0.00025 21.1 0.1 9.6 4 3 7 11 11 11 6 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC41923.1 - 4.5e-11 42.5 0.2 0.00023 20.6 0.0 4.5 2 2 1 4 4 4 2 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 EFC41923.1 - 6.7e-06 26.5 0.0 1.2 9.7 0.0 6.1 7 1 1 8 8 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC41923.1 - 2.7e-05 24.6 0.0 7.5 7.7 0.0 6.5 7 2 2 9 9 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC41923.1 - 0.0002 21.2 0.0 5 7.4 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat MRP-S27 PF10037.9 EFC41923.1 - 0.00024 20.1 0.3 0.63 8.8 0.1 3.3 2 1 0 3 3 3 2 Mitochondrial 28S ribosomal protein S27 ATP13 PF12921.7 EFC41923.1 - 0.00029 20.7 0.7 0.33 10.8 0.0 4.9 4 2 2 6 6 6 1 Mitochondrial ATPase expression ECSIT PF06239.11 EFC41923.1 - 0.01 15.0 0.9 12 5.0 0.0 4.2 4 0 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_2 PF07719.17 EFC41923.1 - 0.019 15.0 0.6 65 4.0 0.0 5.5 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41923.1 - 0.027 14.3 7.9 3.8 7.5 0.0 5.9 8 0 0 8 8 7 0 Tetratricopeptide repeat DUF2175 PF09943.9 EFC41923.1 - 0.035 14.4 5.8 12 6.3 0.0 4.2 5 0 0 5 5 4 0 Uncharacterized protein conserved in archaea (DUF2175) 4HFCP_synth PF04476.13 EFC41923.1 - 0.096 12.4 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 4-HFC-P synthase LRR_8 PF13855.6 EFC41924.1 - 1.4e-31 108.0 64.1 2e-12 46.7 2.8 10.3 7 3 2 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EFC41924.1 - 1.6e-21 76.1 79.0 0.0016 18.8 5.3 12.1 8 3 1 11 11 11 9 Leucine Rich repeats (2 copies) RGS PF00615.19 EFC41924.1 - 8.4e-11 42.2 2.1 8.4e-11 42.2 2.1 4.0 4 0 0 4 4 4 2 Regulator of G protein signaling domain LRR_1 PF00560.33 EFC41924.1 - 5.3e-06 26.3 64.7 0.085 13.5 0.1 18.2 19 0 0 19 19 19 4 Leucine Rich Repeat DSPc PF00782.20 EFC41924.1 - 0.11 12.3 9.6 1.4 8.7 0.1 3.9 3 0 0 3 3 3 0 Dual specificity phosphatase, catalytic domain YjcQ PF09639.10 EFC41924.1 - 0.49 10.6 3.8 5.2 7.3 0.3 4.1 3 1 0 3 3 3 0 YjcQ protein YL1 PF05764.13 EFC41925.1 - 3.7e-31 109.1 39.7 4.8e-31 108.7 39.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 EFC41925.1 - 3.2e-15 55.6 0.1 7.8e-15 54.3 0.1 1.7 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Mitofilin PF09731.9 EFC41925.1 - 0.13 11.1 31.9 0.16 10.8 31.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Peptidase_S64 PF08192.11 EFC41925.1 - 0.36 9.3 16.2 0.41 9.1 16.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 EFC41925.1 - 1.7 5.6 19.2 2.1 5.3 19.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RWP-RK PF02042.15 EFC41926.1 - 3e-06 27.1 0.0 7.3e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 RWP-RK domain FAM177 PF14774.6 EFC41929.1 - 0.0016 18.8 1.1 0.0027 18.0 0.6 1.6 1 1 0 1 1 1 1 FAM177 family Cwf_Cwc_15 PF04889.12 EFC41929.1 - 0.042 13.6 4.5 0.055 13.2 4.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HEAT PF02985.22 EFC41930.1 - 5.8e-25 85.2 8.7 1.3e-05 25.0 0.0 14.3 16 0 0 16 16 16 4 HEAT repeat HEAT_2 PF13646.6 EFC41930.1 - 7.8e-14 51.8 1.7 9.4e-05 22.7 0.0 7.4 5 2 3 8 8 8 3 HEAT repeats HEAT_EZ PF13513.6 EFC41930.1 - 1.5e-11 44.5 3.7 0.023 15.2 0.0 9.8 10 1 0 10 10 10 2 HEAT-like repeat Cohesin_HEAT PF12765.7 EFC41930.1 - 1.2e-05 25.5 0.6 2.1 8.7 0.1 4.6 3 0 0 3 3 3 2 HEAT repeat associated with sister chromatid cohesion Vac14_Fab1_bd PF12755.7 EFC41930.1 - 0.00012 22.6 12.2 1.5 9.4 0.2 8.0 9 0 0 9 9 9 2 Vacuolar 14 Fab1-binding region UME PF08064.13 EFC41930.1 - 0.00033 20.5 5.3 1.3 9.0 0.0 6.0 6 2 1 7 7 7 2 UME (NUC010) domain Condensin2nSMC PF12422.8 EFC41930.1 - 0.045 13.9 9.5 5.7 7.1 0.0 7.8 8 1 1 9 9 9 0 Condensin II non structural maintenance of chromosomes subunit RTP1_C1 PF10363.9 EFC41930.1 - 0.084 13.1 2.0 16 5.7 0.1 5.3 3 1 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 MCR_C PF04609.12 EFC41930.1 - 0.3 10.1 2.2 0.64 9.0 1.2 2.0 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein C RasGEF PF00617.19 EFC41931.1 - 5.7e-11 42.9 0.2 1.1e-10 42.0 0.2 1.5 1 0 0 1 1 1 1 RasGEF domain EF-hand_6 PF13405.6 EFC41932.1 - 1.5e-19 68.2 6.0 2.1e-05 24.0 0.0 8.3 8 0 0 8 8 8 5 EF-hand domain EF-hand_1 PF00036.32 EFC41932.1 - 1.4e-14 52.4 10.2 9.9e-06 24.8 0.1 7.4 8 0 0 8 8 8 4 EF hand EF-hand_7 PF13499.6 EFC41932.1 - 2.3e-14 53.6 13.9 0.0047 17.4 0.0 7.7 6 1 0 6 6 6 3 EF-hand domain pair EF-hand_5 PF13202.6 EFC41932.1 - 3.2e-08 32.7 5.3 1.5e-05 24.3 0.1 4.7 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 EFC41932.1 - 4.8e-07 29.5 5.7 0.0034 17.2 0.1 5.0 5 0 0 5 5 5 2 EF-hand domain pair Caleosin PF05042.13 EFC41932.1 - 1e-06 28.8 0.0 3e-05 24.0 0.0 2.7 2 0 0 2 2 2 1 Caleosin related protein tRNA_synt_1c_R1 PF04558.15 EFC41932.1 - 0.021 14.8 1.2 0.1 12.6 0.3 2.4 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 LysM PF01476.20 EFC41933.1 - 0.00017 21.5 0.0 0.00037 20.5 0.0 1.6 1 0 0 1 1 1 1 LysM domain DUF655 PF04919.12 EFC41933.1 - 0.01 15.8 0.2 0.75 9.7 0.0 2.4 2 1 0 2 2 2 2 Protein of unknown function (DUF655) Acetyltransf_1 PF00583.25 EFC41934.1 - 6e-15 55.5 0.0 7.7e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC41934.1 - 3.9e-10 40.0 0.1 8.5e-10 38.9 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC41934.1 - 1.1e-09 38.3 0.0 7.2e-07 29.2 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC41934.1 - 1.1e-06 28.8 0.0 0.00058 19.9 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC41934.1 - 2.3e-05 25.1 0.0 2.8e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC41934.1 - 0.0012 18.3 0.1 0.0034 16.9 0.1 1.8 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 EFC41934.1 - 0.0025 17.9 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFC41934.1 - 0.0055 16.6 0.0 0.0089 16.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_13 PF13880.6 EFC41934.1 - 0.03 14.3 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_5 PF13444.6 EFC41934.1 - 0.065 13.9 0.0 0.15 12.8 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC41934.1 - 0.092 12.9 0.0 0.52 10.4 0.0 2.0 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Rad60-SLD PF11976.8 EFC41934.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SPRY PF00622.28 EFC41935.1 - 2.1e-08 34.3 1.9 5e-08 33.1 1.9 1.7 1 0 0 1 1 1 1 SPRY domain PMD PF10536.9 EFC41935.1 - 0.026 13.6 1.3 0.042 13.0 1.3 1.3 1 0 0 1 1 1 0 Plant mobile domain BTB PF00651.31 EFC41936.1 - 1.2e-17 64.1 2.9 1.6e-17 63.7 1.4 2.0 2 0 0 2 2 2 1 BTB/POZ domain DUF1325 PF07039.11 EFC41937.1 - 3e-34 118.0 1.0 3e-34 118.0 1.0 2.3 2 0 0 2 2 2 1 SGF29 tudor-like domain Tudor_3 PF18115.1 EFC41937.1 - 1.8e-06 27.7 1.1 3.6e-06 26.7 0.1 2.0 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 EFC41937.1 - 2.1e-06 27.8 0.2 1.7e-05 24.8 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) LBR_tudor PF09465.10 EFC41937.1 - 0.053 13.3 0.5 0.47 10.3 0.0 2.3 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain Ndc1_Nup PF09531.10 EFC41937.1 - 4.2 5.9 11.6 5.9 5.4 11.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mob1_phocein PF03637.17 EFC41938.1 - 6.7e-38 130.3 3.0 6.7e-38 130.3 3.0 2.5 3 0 0 3 3 3 1 Mob1/phocein family RasGAP PF00616.19 EFC41938.1 - 7.9e-25 87.8 8.9 7.9e-25 87.8 8.9 4.0 2 2 1 3 3 3 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 EFC41938.1 - 3e-21 75.7 0.4 7.8e-21 74.3 0.4 1.8 1 0 0 1 1 1 1 C2 domain Vps51 PF08700.11 EFC41938.1 - 0.2 11.8 2.8 2.5 8.2 0.3 3.4 3 1 0 3 3 3 0 Vps51/Vps67 RP-C_C PF11800.8 EFC41938.1 - 0.29 11.2 3.0 0.69 10.0 3.0 1.7 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 EFC41938.1 - 0.49 9.6 1.8 0.79 8.9 1.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 EFC41938.1 - 1.5 8.4 15.6 2.7 7.6 15.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ANAPC_CDC26 PF10471.9 EFC41938.1 - 1.8 9.5 4.8 6.4 7.7 4.8 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF5102 PF17104.5 EFC41939.1 - 9.4 6.2 18.3 5.4 7.0 11.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5102) F-box-like PF12937.7 EFC41940.1 - 2.7e-05 23.9 0.4 7.1e-05 22.6 0.2 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC41940.1 - 0.0016 18.3 0.2 0.005 16.7 0.2 1.9 1 0 0 1 1 1 1 F-box domain DUF3501 PF12007.8 EFC41941.1 - 2.5e-29 102.6 0.0 3.3e-29 102.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3501) Tropomyosin_1 PF12718.7 EFC41942.1 - 0.039 14.1 21.6 0.033 14.3 15.2 2.8 1 1 0 2 2 2 0 Tropomyosin like PAPS_reduct PF01507.19 EFC41942.1 - 0.12 12.5 2.0 0.26 11.3 2.0 1.9 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family TolA_bind_tri PF16331.5 EFC41942.1 - 0.2 11.7 0.1 0.2 11.7 0.1 2.7 3 0 0 3 3 3 0 TolA binding protein trimerisation NleF_casp_inhib PF16809.5 EFC41942.1 - 0.49 10.3 14.1 0.15 11.9 9.6 2.1 1 1 1 2 2 2 0 NleF caspase inhibitor PIN_8 PF18476.1 EFC41942.1 - 0.99 9.2 9.6 1.2 8.9 9.6 1.2 1 0 0 1 1 1 0 PIN like domain Fib_alpha PF08702.10 EFC41942.1 - 1.3 9.2 19.4 1.5 9.0 6.8 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 EFC41942.1 - 1.4 8.2 7.5 2.6 7.3 7.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EFC41942.1 - 1.6 8.8 13.3 0.16 12.0 3.8 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF2508 PF10704.9 EFC41942.1 - 3.1 8.0 12.2 0.88 9.8 2.7 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2508) DUF724 PF05266.14 EFC41942.1 - 3.2 7.5 16.8 0.11 12.3 8.5 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF724) TFR_dimer PF04253.15 EFC41942.1 - 3.2 7.9 6.0 23 5.1 4.7 2.4 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain RNA_polI_A14 PF08203.11 EFC41942.1 - 8.5 7.2 8.4 3 8.6 2.7 2.4 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 Csm1_N PF18504.1 EFC41942.1 - 9.1 6.7 19.7 1.4 9.3 2.2 3.8 3 2 1 4 4 4 0 Csm1 N-terminal domain Abhydrolase_1 PF00561.20 EFC41943.1 - 1.4e-06 28.2 8.0 2.2e-06 27.5 0.0 3.8 3 2 1 4 4 4 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC41943.1 - 0.02 15.5 0.0 0.046 14.3 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family DUF370 PF04025.12 EFC41944.1 - 0.055 13.6 2.7 0.2 11.8 0.5 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF370) DUF836 PF05768.14 EFC41944.1 - 4.6 7.7 5.6 18 5.8 0.9 2.8 2 1 0 2 2 2 0 Glutaredoxin-like domain (DUF836) SHIPPO-rpt PF07004.12 EFC41946.1 - 5.8e-33 112.3 61.8 0.00098 19.9 1.4 12.4 12 0 0 12 12 12 12 Sperm-tail PG-rich repeat YtkA PF13115.6 EFC41946.1 - 0.0097 16.5 1.9 42 4.8 0.1 6.0 9 1 0 9 9 9 1 YtkA-like Actin PF00022.19 EFC41947.1 - 2.3e-35 122.0 0.0 1e-33 116.6 0.0 2.2 1 1 0 1 1 1 1 Actin SHOCT PF09851.9 EFC41947.1 - 8.4e-10 38.1 4.3 8.4e-10 38.1 4.3 2.5 2 0 0 2 2 2 1 Short C-terminal domain Adaptin_binding PF10199.9 EFC41947.1 - 0.007 17.0 4.4 0.014 16.0 3.4 2.0 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 SDA1 PF05285.12 EFC41947.1 - 0.024 14.1 13.0 0.041 13.3 13.0 1.3 1 0 0 1 1 1 0 SDA1 DUF2937 PF11157.8 EFC41947.1 - 0.19 11.4 0.3 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) WD40 PF00400.32 EFC41948.1 - 5.9e-11 42.8 2.3 0.0018 19.0 0.2 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC41948.1 - 0.016 15.5 0.0 0.79 10.1 0.0 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RICTOR_phospho PF14665.6 EFC41948.1 - 0.027 14.8 0.1 0.077 13.3 0.1 1.8 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site Apyrase PF06079.11 EFC41949.1 - 1.7e-96 322.9 2.1 2e-96 322.6 2.1 1.0 1 0 0 1 1 1 1 Apyrase Ribosomal_L26 PF16906.5 EFC41949.1 - 0.15 12.5 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal proteins L26 eukaryotic, L24P archaeal PI3_PI4_kinase PF00454.27 EFC41950.1 - 2.1e-42 145.6 0.6 8.5e-42 143.7 0.6 2.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SMG1 PF15785.5 EFC41950.1 - 3.4e-11 42.3 8.3 6.8e-07 28.1 0.4 4.1 3 1 1 4 4 4 2 Serine/threonine-protein kinase smg-1 FATC PF02260.20 EFC41950.1 - 1.7e-05 24.6 0.0 3.9e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 FATC domain TIM21 PF08294.11 EFC41950.1 - 0.12 12.3 0.0 3.4 7.6 0.0 2.6 2 0 0 2 2 2 0 TIM21 FRB_dom PF08771.11 EFC41950.1 - 0.74 10.3 12.5 0.16 12.4 0.4 5.1 4 1 1 5 5 5 0 FKBP12-rapamycin binding domain LOH1CR12 PF10158.9 EFC41951.1 - 0.031 14.3 1.3 0.068 13.2 1.3 1.6 1 0 0 1 1 1 0 Tumour suppressor protein Nup_retrotrp_bd PF10599.9 EFC41951.1 - 0.041 14.6 2.0 0.92 10.2 0.0 2.3 2 0 0 2 2 2 0 Retro-transposon transporting motif Mce4_CUP1 PF11887.8 EFC41951.1 - 0.041 13.3 0.4 0.086 12.3 0.1 1.6 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Cellulose_synt PF03552.14 EFC41951.1 - 0.14 10.6 0.0 0.17 10.3 0.0 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF2570 PF10828.8 EFC41951.1 - 0.23 11.3 2.0 0.61 9.9 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Metallophos PF00149.28 EFC41952.1 - 0.0017 18.9 0.2 0.0021 18.6 0.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NUDIX_2 PF13869.6 EFC41954.1 - 1.4e-68 230.2 0.2 1.6e-68 230.1 0.2 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 EFC41954.1 - 0.047 13.7 0.0 0.07 13.2 0.0 1.5 1 0 0 1 1 1 0 NUDIX domain Ras PF00071.22 EFC41955.1 - 6.8e-15 55.0 0.0 8.3e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41955.1 - 8.5e-07 29.2 0.0 1.3e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC41955.1 - 0.011 15.1 0.1 0.013 14.9 0.1 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Arf PF00025.21 EFC41955.1 - 0.027 13.9 0.0 0.029 13.8 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family Pkinase PF00069.25 EFC41956.1 - 9.1e-32 110.5 0.1 9.1e-32 110.5 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain DSPc PF00782.20 EFC41956.1 - 2.5e-18 66.2 2.2 2.6e-18 66.1 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Pkinase_Tyr PF07714.17 EFC41956.1 - 4e-16 59.1 0.0 8.4e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase ATP-cone PF03477.16 EFC41957.1 - 0.0078 16.8 0.3 5.3 7.7 0.0 3.3 3 0 0 3 3 3 2 ATP cone domain PPL4 PF18188.1 EFC41960.1 - 1.8e-58 197.0 1.9 3.1e-58 196.2 1.9 1.4 1 0 0 1 1 1 1 Prim-pol 4 MJ1316 PF04457.12 EFC41960.1 - 1.6e-15 57.6 0.2 5.4e-15 55.9 0.2 1.9 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Band_3_cyto PF07565.13 EFC41960.1 - 0.8 9.4 15.3 0.079 12.8 3.3 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Sporozoite_P67 PF05642.11 EFC41960.1 - 2.3 6.2 11.9 3.6 5.5 11.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Methyltransf_16 PF10294.9 EFC41961.1 - 2.1e-17 63.4 0.0 6.3e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 Lysine methyltransferase Methyltransf_12 PF08242.12 EFC41961.1 - 0.0038 18.0 0.5 0.0087 16.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC41961.1 - 0.0041 17.0 0.0 0.0069 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC41961.1 - 0.09 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain tRNA_int_endo PF01974.17 EFC41962.1 - 2e-19 69.4 0.0 2.9e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain zf-RING_2 PF13639.6 EFC41963.1 - 2.2e-10 40.7 8.0 2.2e-10 40.7 8.0 1.8 2 0 0 2 2 1 1 Ring finger domain zf-rbx1 PF12678.7 EFC41963.1 - 5.5e-08 33.0 8.2 1.5e-07 31.6 8.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFC41963.1 - 1.2e-07 31.5 4.7 2.6e-07 30.4 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC41963.1 - 1.4e-06 28.0 6.9 3.4e-06 26.8 6.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC41963.1 - 2.5e-06 27.4 5.9 2.5e-06 27.4 5.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFC41963.1 - 1.7e-05 24.6 7.0 4.1e-05 23.3 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC41963.1 - 3.1e-05 23.8 6.0 9.2e-05 22.3 6.0 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Rtf2 PF04641.12 EFC41963.1 - 4.7e-05 22.9 1.7 7.5e-05 22.2 1.7 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 EFC41963.1 - 0.00059 19.7 6.8 0.0013 18.6 6.0 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFC41963.1 - 0.00094 19.2 0.7 0.0024 17.9 0.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-UDP PF14569.6 EFC41963.1 - 0.0054 16.8 0.8 0.03 14.4 1.1 2.1 2 0 0 2 2 2 1 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 EFC41963.1 - 0.01 16.0 6.4 0.064 13.4 6.3 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 EFC41963.1 - 0.014 15.3 0.2 0.034 14.0 0.2 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zinc_ribbon_16 PF17034.5 EFC41963.1 - 0.035 14.3 1.2 0.14 12.4 1.2 2.0 1 0 0 1 1 1 0 Zinc-ribbon like family Circo_capsid PF02443.15 EFC41963.1 - 0.085 12.4 2.6 0.17 11.5 2.6 1.4 1 0 0 1 1 1 0 Circovirus capsid protein zf-Nse PF11789.8 EFC41963.1 - 0.11 12.4 1.8 0.29 11.0 1.8 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 EFC41963.1 - 0.15 11.7 6.1 0.33 10.6 6.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 EFC41963.1 - 2.7 7.9 5.1 15 5.4 5.3 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 EFC41963.1 - 4.5 7.5 7.0 12 6.1 7.0 1.8 1 1 0 1 1 1 0 RING-variant domain FYVE_2 PF02318.16 EFC41963.1 - 4.7 7.5 11.2 0.62 10.3 1.0 2.6 3 0 0 3 3 2 0 FYVE-type zinc finger Peptidase_C71 PF12386.8 EFC41964.1 - 0.026 14.2 1.2 3.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Pseudomurein endo-isopeptidase Pei Gag_p17 PF00540.18 EFC41964.1 - 0.048 13.7 0.5 0.094 12.7 0.4 1.6 1 1 0 1 1 1 0 gag gene protein p17 (matrix protein) Robl_LC7 PF03259.17 EFC41965.1 - 1.5e-24 85.6 0.0 1.8e-24 85.3 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 EFC41965.1 - 0.00019 21.3 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 DUF1043 PF06295.12 EFC41966.1 - 0.021 14.8 0.5 0.021 14.8 0.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) DUF4795 PF16043.5 EFC41966.1 - 0.16 11.6 5.8 0.27 10.8 1.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DUF4200 PF13863.6 EFC41966.1 - 2.4 8.6 9.8 5.4 7.4 1.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) SlyX PF04102.12 EFC41966.1 - 3 8.5 6.5 0.68 10.6 0.7 2.7 3 0 0 3 3 3 0 SlyX Tristanin_u2 PF16638.5 EFC41966.1 - 7 7.5 7.3 6 7.7 2.7 2.7 2 1 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers TPR_8 PF13181.6 EFC41967.1 - 0.00069 19.6 0.4 0.0042 17.2 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC41967.1 - 0.00073 19.8 0.0 0.48 10.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC41967.1 - 0.00098 19.3 0.1 0.015 15.6 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC41967.1 - 0.0011 19.0 0.1 0.16 12.2 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC41967.1 - 0.0031 17.3 0.3 0.018 14.8 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TOM20_plant PF06552.12 EFC41967.1 - 0.062 13.1 2.3 0.066 12.9 0.7 1.9 2 0 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_7 PF13176.6 EFC41967.1 - 0.063 13.3 0.0 0.32 11.1 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41967.1 - 0.1 12.3 1.1 13 5.5 0.0 2.9 3 0 0 3 3 3 0 TPR repeat 3Beta_HSD PF01073.19 EFC41968.1 - 1.2e-20 73.7 0.8 1.9e-18 66.5 0.8 2.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC41968.1 - 2.8e-06 27.0 0.0 1.3e-05 24.8 0.0 2.1 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFC41968.1 - 7.7e-06 25.3 0.1 3.7e-05 23.0 0.1 1.9 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 EFC41968.1 - 0.0008 19.4 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 KR domain Ribosomal_S17_N PF16205.5 EFC41968.1 - 0.1 13.0 0.1 0.28 11.6 0.1 1.7 1 0 0 1 1 1 0 Ribosomal_S17 N-terminal Fip1 PF05182.13 EFC41969.1 - 2.8e-22 77.9 3.2 4.8e-22 77.2 3.2 1.4 1 0 0 1 1 1 1 Fip1 motif DUF4116 PF13475.6 EFC41970.1 - 2.5e-14 52.7 3.6 4.4e-10 39.1 0.2 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF4116) DEAD PF00270.29 EFC41970.1 - 3e-13 49.9 0.0 6.6e-13 48.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC41970.1 - 4.8e-08 33.3 4.0 1.6e-07 31.7 0.1 3.6 3 1 1 4 4 4 1 Helicase conserved C-terminal domain Ras PF00071.22 EFC41971.1 - 3.4e-44 150.3 0.0 4e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC41971.1 - 7e-13 48.9 0.0 1.2e-12 48.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC41971.1 - 0.00016 21.2 0.0 0.0002 20.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC41971.1 - 0.0022 17.5 0.0 0.0043 16.6 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC41971.1 - 0.0025 17.7 0.0 0.1 12.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Pacs-1 PF10254.9 EFC41972.1 - 8.3e-23 81.0 13.2 8.3e-23 81.0 13.2 2.5 2 1 0 2 2 2 1 PACS-1 cytosolic sorting protein RCC1 PF00415.18 EFC41973.1 - 1.1e-30 106.0 9.7 1.7e-07 31.8 0.0 6.8 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC41973.1 - 1e-19 69.8 10.2 1.5e-05 24.7 0.1 7.1 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC41973.1 - 0.012 15.8 0.2 3 8.1 0.1 3.7 3 1 0 3 3 3 0 Putative heavy-metal chelation Ank_2 PF12796.7 EFC41974.1 - 2.8e-47 159.2 25.9 5.3e-15 55.8 0.8 4.7 1 1 5 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC41974.1 - 9.8e-35 118.5 3.9 3.9e-12 46.4 0.0 5.7 6 0 0 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC41974.1 - 1.2e-32 108.2 6.2 3.1e-05 24.0 0.0 8.7 9 1 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 EFC41974.1 - 8.4e-31 105.6 10.1 1.3e-05 25.4 0.1 7.7 3 2 5 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 EFC41974.1 - 6.9e-30 102.2 1.8 0.00019 21.7 0.0 8.9 9 0 0 9 9 9 6 Ankyrin repeat RnaseA PF00074.20 EFC41974.1 - 0.023 15.1 0.1 0.36 11.3 0.0 2.4 2 0 0 2 2 2 0 Pancreatic ribonuclease Lactamase_B_6 PF16661.5 EFC41975.1 - 4.7e-13 49.0 1.2 6.1e-12 45.4 0.1 2.8 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 EFC41975.1 - 0.00021 21.6 0.4 0.0014 18.9 0.0 2.5 2 1 0 2 2 2 1 Beta-Casp domain Beta_lactamase3 PF17030.5 EFC41975.1 - 0.00066 19.0 0.7 0.0049 16.1 0.1 2.5 2 0 0 2 2 2 1 Putative beta-lactamase-like family Stealth_CR2 PF11380.8 EFC41975.1 - 0.041 14.0 0.0 0.15 12.2 0.0 1.9 1 0 0 1 1 1 0 Stealth protein CR2, conserved region 2 DUF3776 PF12618.8 EFC41975.1 - 0.043 14.4 0.8 0.13 12.8 0.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3776) EXS PF03124.14 EFC41976.1 - 4.3e-33 115.0 7.7 6.7e-33 114.4 7.7 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 EFC41976.1 - 6.6e-09 36.2 21.0 7.4e-06 26.1 13.0 2.3 1 1 1 2 2 2 2 SPX domain DUF2089 PF09862.9 EFC41976.1 - 0.0096 15.9 0.2 0.027 14.5 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2089) MPM1 PF17234.2 EFC41976.1 - 0.013 15.7 6.0 0.013 15.7 6.0 2.0 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 USP8_interact PF08941.10 EFC41976.1 - 0.074 12.9 3.7 15 5.4 4.1 2.4 2 0 0 2 2 2 0 USP8 interacting End3 PF12761.7 EFC41976.1 - 4.9 7.3 13.5 1.1 9.3 7.8 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 FNIP_M PF14637.6 EFC41977.1 - 8e-20 71.8 3.9 3.8e-19 69.6 3.9 2.1 1 1 0 1 1 1 1 Folliculin-interacting protein middle domain FNIP_C PF14638.6 EFC41977.1 - 1.5e-19 70.4 0.0 5.5e-14 52.2 0.0 2.8 2 0 0 2 2 2 2 Folliculin-interacting protein C-terminus FNIP_N PF14636.6 EFC41977.1 - 4.3e-19 70.0 3.6 4.3e-19 70.0 3.6 2.8 2 0 0 2 2 2 1 Folliculin-interacting protein N-terminus DUF4604 PF15377.6 EFC41977.1 - 0.081 13.3 3.6 0.44 10.9 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) ThiF PF00899.21 EFC41980.1 - 1.1e-93 313.1 0.0 1.5e-65 221.0 0.0 2.3 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFC41980.1 - 6.9e-67 226.0 3.3 1.6e-66 224.8 3.3 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 EFC41980.1 - 1.9e-19 69.6 0.9 7.6e-19 67.7 0.5 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EFC41980.1 - 1.3e-15 57.3 0.1 5.1e-15 55.4 0.1 2.1 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_UFD PF09358.10 EFC41980.1 - 2.4e-10 40.9 0.1 8.5e-10 39.2 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin fold domain Shikimate_DH PF01488.20 EFC41980.1 - 3.7e-05 23.8 0.6 0.019 15.0 0.1 2.9 2 1 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Pyr_redox_2 PF07992.14 EFC41980.1 - 0.0032 16.8 0.0 0.29 10.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 EFC41980.1 - 0.0093 16.4 0.2 0.34 11.4 0.0 2.9 2 1 0 2 2 2 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 EFC41980.1 - 0.087 12.2 0.0 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFC41980.1 - 0.16 12.6 3.3 8.5 7.0 0.1 3.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase RNA_pol_Rpb1_5 PF04998.17 EFC41982.1 - 8.7e-100 333.6 0.2 1.9e-99 332.5 0.1 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EFC41982.1 - 6.6e-95 318.0 4.9 2.9e-94 315.9 4.9 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EFC41982.1 - 4.8e-73 244.8 0.1 1.2e-72 243.5 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 EFC41982.1 - 4.8e-49 166.8 3.4 1.1e-48 165.7 3.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 EFC41982.1 - 4e-44 150.3 1.3 1.4e-41 142.0 0.0 4.2 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 EFC41982.1 - 1e-39 135.6 4.1 2e-39 134.7 4.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 EFC41982.1 - 1.1e-36 125.0 0.3 6e-36 122.7 0.3 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DNA_pol_A_exo1 PF01612.20 EFC41983.1 - 0.032 13.9 0.0 0.15 11.8 0.0 2.0 1 1 0 1 1 1 0 3'-5' exonuclease RolB_RolC PF02027.17 EFC41983.1 - 0.2 11.3 1.0 0.79 9.4 0.0 2.2 2 0 0 2 2 2 0 RolB/RolC glucosidase family G-alpha PF00503.20 EFC41984.1 - 1.2e-43 149.6 21.3 1.2e-43 149.6 21.3 2.2 1 1 1 2 2 2 1 G-protein alpha subunit Kelch_4 PF13418.6 EFC41984.1 - 5.7e-26 90.3 0.8 6.3e-05 22.9 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC41984.1 - 1.6e-23 82.2 1.9 0.00014 21.8 0.1 6.6 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFC41984.1 - 1.4e-19 69.9 1.8 9.6e-08 32.1 0.0 6.9 5 2 1 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC41984.1 - 4.3e-19 68.1 3.8 3e-07 30.5 0.1 6.5 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFC41984.1 - 2.8e-15 55.6 3.5 1.1e-06 28.1 0.1 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFC41984.1 - 5.4e-11 42.0 5.6 2.6e-05 24.0 0.1 5.6 6 0 0 6 6 6 1 Kelch motif ANAPC3 PF12895.7 EFC41984.1 - 0.00024 21.2 0.5 0.00065 19.9 0.5 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EFC41984.1 - 0.0018 18.0 0.0 0.41 10.5 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC41984.1 - 0.0019 18.3 0.1 0.18 12.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC41984.1 - 0.017 14.8 0.0 0.037 13.7 0.0 1.6 1 0 0 1 1 1 0 TPR repeat TPR_2 PF07719.17 EFC41984.1 - 0.022 14.8 0.0 0.72 10.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC41984.1 - 0.043 14.3 0.1 0.36 11.4 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC41984.1 - 0.053 14.4 0.0 0.83 10.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ARL2_Bind_BART PF11527.8 EFC41984.1 - 0.059 13.5 1.8 0.31 11.1 0.2 3.0 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART Alkyl_sulf_dimr PF14863.6 EFC41984.1 - 0.066 13.7 0.2 16 5.9 0.3 2.5 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation SH3BGR PF04908.15 EFC41984.1 - 0.098 12.8 0.7 0.61 10.3 0.1 2.5 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein Ribosomal_L27_C PF18471.1 EFC41984.1 - 0.36 10.2 7.4 0.67 9.3 0.2 3.5 3 0 0 3 3 3 0 Ribosomal L27 protein C-terminal domain Nipped-B_C PF12830.7 EFC41984.1 - 0.44 10.5 4.8 0.16 11.9 0.2 2.6 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus RGS PF00615.19 EFC41985.1 - 2e-15 57.1 0.1 8.8e-15 55.0 0.1 2.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Piwi PF02171.17 EFC41986.1 - 1.4e-76 257.6 1.6 2.1e-76 257.1 1.6 1.3 1 0 0 1 1 1 1 Piwi domain PAZ PF02170.22 EFC41986.1 - 3.7e-26 91.6 2.6 1e-25 90.2 2.6 1.7 1 0 0 1 1 1 1 PAZ domain ArgoN PF16486.5 EFC41986.1 - 1.9e-10 41.5 1.1 1.9e-10 41.5 1.1 2.0 2 0 0 2 2 2 1 N-terminal domain of argonaute THF_DHG_CYH PF00763.23 EFC41986.1 - 0.00069 19.9 0.6 0.0069 16.6 0.1 2.8 2 1 1 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain ArgoL1 PF08699.10 EFC41986.1 - 0.054 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 Argonaute linker 1 domain LRR_6 PF13516.6 EFC41987.1 - 5.9e-43 141.3 20.1 0.0012 18.7 0.0 11.3 11 0 0 11 11 11 10 Leucine Rich repeat LRR_8 PF13855.6 EFC41987.1 - 5e-22 77.4 20.0 2.5e-06 27.2 0.5 5.0 3 1 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC41987.1 - 1.8e-17 63.1 33.4 4.8e-05 23.6 0.5 7.5 2 2 8 10 10 10 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC41987.1 - 6.1e-06 26.1 14.6 4.4 8.2 0.1 9.1 10 3 0 10 10 10 1 Leucine Rich Repeat DUF1825 PF08855.10 EFC41987.1 - 0.0024 17.8 3.3 1.2 9.0 0.1 4.1 2 2 2 4 4 4 1 Domain of unknown function (DUF1825) Apo-VLDL-II PF05418.11 EFC41987.1 - 0.0081 16.7 0.0 1 10.0 0.0 3.0 2 1 0 2 2 2 1 Apovitellenin I (Apo-VLDL-II) F-box-like PF12937.7 EFC41987.1 - 0.03 14.2 0.1 0.055 13.4 0.1 1.4 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC41987.1 - 0.034 14.0 0.4 0.065 13.1 0.4 1.5 1 0 0 1 1 1 0 F-box domain RNA_pol_A_CTD PF03118.15 EFC41987.1 - 0.071 12.9 7.8 4.5 7.1 0.1 4.2 2 2 1 3 3 3 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF4869 PF16163.5 EFC41987.1 - 0.08 12.7 9.2 3.6 7.3 0.3 4.2 1 1 2 4 4 4 0 Domain of unknown function (DUF4869) PglZ PF08665.12 EFC41987.1 - 0.22 11.6 3.1 18 5.4 0.7 2.9 1 1 1 2 2 2 0 PglZ domain PulA_N1 PF17999.1 EFC41987.1 - 1.5 9.6 9.6 7 7.5 0.1 3.6 4 0 0 4 4 3 0 Pullulanase N1-terminal domain ApoB100_C PF12491.8 EFC41987.1 - 2.2 8.3 8.7 49 4.0 0.0 5.3 2 2 2 4 4 4 0 Apolipoprotein B100 C terminal Pkinase_Tyr PF07714.17 EFC41988.1 - 1.7e-51 175.0 1.6 1.4e-47 162.2 0.8 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC41988.1 - 9.9e-51 172.6 0.7 1.8e-50 171.7 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC41988.1 - 0.00015 20.7 0.0 0.00023 20.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Sterile PF03015.19 EFC41988.1 - 0.071 13.3 0.2 6.8 7.0 0.0 2.7 2 0 0 2 2 2 0 Male sterility protein Beta_helix PF13229.6 EFC41988.1 - 0.22 11.4 32.0 0.79 9.6 2.2 3.9 1 1 1 3 3 3 0 Right handed beta helix region TM2 PF05154.16 EFC41989.1 - 9.8e-10 38.6 7.3 9.8e-10 38.6 7.3 2.6 2 0 0 2 2 2 1 TM2 domain DUF5453 PF17534.2 EFC41989.1 - 2.3 8.2 7.8 0.2 11.6 2.6 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5453) Myb_DNA-binding PF00249.31 EFC41990.1 - 6.6e-15 55.0 1.5 1.6e-14 53.8 1.5 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC41990.1 - 1.3e-05 25.0 2.7 1.3e-05 25.0 2.7 3.3 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFC41990.1 - 2.9e-05 24.2 2.4 4.8e-05 23.5 0.5 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain MgtE_N PF03448.17 EFC41990.1 - 0.069 13.8 1.0 0.55 10.9 0.1 2.7 2 1 0 2 2 2 0 MgtE intracellular N domain UvdE PF03851.14 EFC41991.1 - 5.3e-55 186.6 0.7 7.2e-55 186.2 0.7 1.1 1 0 0 1 1 1 1 UV-endonuclease UvdE TPPK_C PF12555.8 EFC41993.1 - 0.022 14.8 0.1 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal Ycf70 PF17382.2 EFC41993.1 - 0.025 15.0 0.1 0.044 14.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized Ycf70-like Ribonuc_red_lgC PF02867.15 EFC41994.1 - 3.5e-186 619.8 0.0 4.6e-186 619.4 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 EFC41994.1 - 5.5e-25 87.2 0.0 7.5e-24 83.6 0.0 2.4 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 EFC41994.1 - 3.8e-08 33.8 1.6 1.1e-07 32.3 0.4 2.2 2 0 0 2 2 2 1 ATP cone domain Actin PF00022.19 EFC41995.1 - 1e-45 156.1 0.0 4.2e-44 150.8 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC41995.1 - 2.7e-05 23.1 0.1 0.00021 20.2 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein ROK PF00480.20 EFC41995.1 - 0.073 12.5 0.1 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 ROK family PKD PF00801.20 EFC41996.1 - 0.00046 20.0 1.3 0.0016 18.2 1.3 2.1 1 1 0 1 1 1 1 PKD domain DUF2207 PF09972.9 EFC41997.1 - 0.015 14.1 0.2 0.02 13.7 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PrgI PF12666.7 EFC41997.1 - 0.05 14.3 0.8 0.083 13.6 0.8 1.3 1 0 0 1 1 1 0 PrgI family protein NECFESHC PF16621.5 EFC41997.1 - 0.13 12.3 0.7 0.24 11.4 0.7 1.4 1 0 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 Spore_YabQ PF09578.10 EFC41997.1 - 0.31 11.3 4.5 0.09 13.0 1.7 1.5 2 0 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) AAA PF00004.29 EFC41998.1 - 2.9e-32 111.9 0.0 6.7e-32 110.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFC41998.1 - 4.4e-12 45.8 0.0 1.7e-11 44.0 0.0 2.0 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFC41998.1 - 7.3e-08 32.1 0.0 2.1e-07 30.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain MitMem_reg PF13012.6 EFC41999.1 - 1.2e-21 77.2 0.2 2.7e-21 76.1 0.2 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 EFC41999.1 - 1.5e-19 70.1 0.2 2.5e-19 69.4 0.2 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Glyoxalase PF00903.25 EFC42000.1 - 1.1e-22 80.5 0.0 1.3e-22 80.4 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 EFC42000.1 - 1e-09 38.6 0.0 3.4e-09 37.0 0.0 1.7 1 1 1 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 EFC42000.1 - 2.6e-06 28.2 0.0 4.3e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 EFC42000.1 - 0.00095 19.1 0.0 0.0022 17.9 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase-like domain WD40 PF00400.32 EFC42001.1 - 2.3e-14 53.5 11.7 6e-06 26.9 0.1 6.8 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42001.1 - 3.4e-10 40.1 0.0 0.0049 17.1 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC42001.1 - 0.0021 16.8 0.0 0.0043 15.8 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Mcl1_mid PF12341.8 EFC42001.1 - 0.003 17.0 0.0 0.012 15.0 0.0 1.9 1 1 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region TAF1D PF15333.6 EFC42001.1 - 0.31 10.8 4.9 0.58 9.9 4.9 1.4 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D ubiquitin PF00240.23 EFC42002.1 - 9.2e-102 332.9 13.9 2.1e-33 113.9 0.7 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 EFC42002.1 - 7.5e-50 166.6 14.2 4.2e-16 58.5 0.7 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC42002.1 - 3.2e-18 66.0 6.4 0.00018 21.9 0.2 4.6 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC42002.1 - 8.9e-13 48.0 3.0 0.0098 15.8 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC42002.1 - 1.3e-12 47.9 4.9 0.0081 16.5 0.1 3.1 1 1 2 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC42002.1 - 1.1e-11 44.8 2.0 0.041 14.0 0.1 4.0 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC42002.1 - 3.8e-10 40.3 0.7 0.15 12.7 0.0 3.2 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC42002.1 - 6.9e-09 35.7 0.2 0.25 11.2 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EFC42002.1 - 1.1e-07 31.8 16.8 3.3 7.8 0.2 6.0 6 0 0 6 6 6 3 Ubiquitin-like domain DUF3861 PF12977.7 EFC42002.1 - 4.4e-05 23.5 1.2 6.2 7.1 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 EFC42002.1 - 0.00018 21.8 0.2 20 5.6 0.0 4.0 3 3 0 3 3 3 0 Protein of unknown function (DUF2870) Methyltrans_RNA PF04452.14 EFC42002.1 - 0.00032 20.1 0.3 0.8 9.0 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase ACT_5 PF13710.6 EFC42002.1 - 0.00037 20.3 2.9 7.7 6.4 0.1 3.3 3 0 0 3 3 3 0 ACT domain UDP-g_GGTase PF06427.11 EFC42002.1 - 0.00088 19.4 4.9 1.3 9.2 0.1 3.3 4 0 0 4 4 3 2 UDP-glucose:Glycoprotein Glucosyltransferase RBD PF02196.15 EFC42002.1 - 0.0012 18.9 0.0 25 5.0 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain YcgR_2 PF12945.7 EFC42002.1 - 0.0014 18.7 2.9 15 5.8 0.1 3.3 3 0 0 3 3 3 0 Flagellar protein YcgR DUF1866 PF08952.11 EFC42002.1 - 0.0031 17.4 0.3 25 4.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) UN_NPL4 PF11543.8 EFC42002.1 - 0.0033 17.9 1.5 28 5.3 0.0 3.3 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 ProRS-C_2 PF09181.10 EFC42002.1 - 0.0037 17.3 5.9 11 6.2 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal DUF969 PF06149.12 EFC42002.1 - 0.0074 15.7 0.0 14 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) Tash_PEST PF07708.11 EFC42002.1 - 0.0075 16.4 6.8 11 6.3 0.2 3.4 3 0 0 3 3 3 0 Tash protein PEST motif NETI PF14044.6 EFC42002.1 - 0.014 15.1 2.9 32 4.4 0.1 4.0 3 3 0 3 3 3 0 NETI protein Big_7 PF17957.1 EFC42002.1 - 0.021 15.6 0.0 90 3.9 0.0 3.1 3 0 0 3 3 3 0 Bacterial Ig domain Raf1_HTH PF18579.1 EFC42002.1 - 0.031 14.0 0.0 71 3.2 0.0 3.2 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain ACT_4 PF13291.6 EFC42002.1 - 0.034 14.8 0.5 94 3.7 0.0 3.3 3 0 0 3 3 3 0 ACT domain ORF11CD3 PF10549.9 EFC42002.1 - 0.051 13.7 0.0 62 3.8 0.0 3.8 3 0 0 3 3 3 0 ORF11CD3 domain HAMP_N3 PF18575.1 EFC42002.1 - 0.15 11.7 4.4 38 3.9 0.1 3.2 3 0 0 3 3 3 0 HAMP N-terminal domain 3 Phage_sheath_1N PF17481.2 EFC42002.1 - 0.16 12.5 4.2 82 3.8 4.2 3.1 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain PI3K_p85B PF02192.16 EFC42002.1 - 0.17 11.6 6.1 30 4.4 0.1 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain DMA PF03474.14 EFC42002.1 - 0.25 11.0 1.5 72 3.1 0.0 3.3 3 0 0 3 3 3 0 DMRTA motif Plexin_cytopl PF08337.12 EFC42002.1 - 0.31 9.7 9.9 8.1 5.0 0.3 3.9 2 1 0 3 3 3 0 Plexin cytoplasmic RasGAP domain Myosin_N PF02736.19 EFC42002.1 - 0.63 9.9 4.8 72 3.3 0.1 4.3 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain HlyIII PF03006.20 EFC42003.1 - 1.4e-21 77.2 25.1 2.1e-21 76.7 25.1 1.2 1 0 0 1 1 1 1 Haemolysin-III related FeoB_associated PF12669.7 EFC42003.1 - 0.61 10.5 3.8 1.5 9.2 0.7 2.7 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein EF-hand_6 PF13405.6 EFC42004.1 - 7.4e-16 56.7 4.8 1.4e-05 24.7 0.0 3.7 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EFC42004.1 - 1.6e-15 55.4 8.1 6.4e-05 22.2 0.0 3.8 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 EFC42004.1 - 3.5e-14 53.0 6.6 1.7e-08 34.8 1.6 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFC42004.1 - 1.2e-07 31.4 2.5 6.2e-05 22.8 0.1 2.7 1 1 2 3 3 3 2 EF-hand domain pair EFhand_Ca_insen PF08726.10 EFC42004.1 - 6.1e-06 26.2 0.4 1.9e-05 24.7 0.0 1.9 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_5 PF13202.6 EFC42004.1 - 4.8e-05 22.7 3.9 0.55 9.8 0.0 3.5 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.9 EFC42004.1 - 0.003 17.9 2.7 0.0038 17.5 0.7 2.0 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Methyltransf_5 PF01795.19 EFC42004.1 - 0.0077 15.8 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 MraW methylase family EF-hand_9 PF14658.6 EFC42004.1 - 0.016 15.5 0.0 2.2 8.6 0.0 2.4 1 1 1 2 2 2 0 EF-hand domain OST-HTH PF12872.7 EFC42004.1 - 0.081 12.8 0.0 0.56 10.1 0.0 2.2 1 1 2 3 3 3 0 OST-HTH/LOTUS domain Uteroglobin PF01099.17 EFC42004.1 - 0.088 13.2 2.5 0.091 13.1 1.3 1.6 2 0 0 2 2 2 0 Uteroglobin family Ank_2 PF12796.7 EFC42005.1 - 4.1e-23 81.8 3.8 2.2e-09 37.8 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC42005.1 - 7.8e-21 73.9 1.8 3.5e-10 39.9 0.2 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC42005.1 - 1.2e-15 57.7 3.1 2.7e-09 37.4 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42005.1 - 2.6e-15 55.0 2.4 0.0015 18.8 0.0 6.1 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 EFC42005.1 - 1.7e-07 31.3 1.8 0.095 13.2 0.1 4.2 4 0 0 4 4 4 2 Ankyrin repeat Zn_clus PF00172.18 EFC42005.1 - 4.3e-07 29.9 10.9 8.7e-07 29.0 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BILBO1_N PF18281.1 EFC42006.1 - 0.18 12.2 0.5 0.81 10.2 0.2 2.2 2 1 0 2 2 2 0 BILBO1 N-terminal domain WSK PF03832.13 EFC42006.1 - 0.99 9.1 4.7 1.6 8.5 4.7 1.3 1 0 0 1 1 1 0 WSK motif RCC1_2 PF13540.6 EFC42008.1 - 4.4e-08 32.7 0.1 0.00054 19.7 0.0 3.8 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC42008.1 - 0.00077 20.0 0.0 0.067 13.8 0.0 3.3 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC42009.1 - 5e-55 183.5 369.8 9.2e-05 22.7 7.6 22.2 22 0 0 22 22 22 21 EGF-like domain EGF PF00008.27 EFC42009.1 - 0.016 15.5 2.6 0.016 15.5 2.6 22.0 22 0 0 22 22 22 0 EGF-like domain KH_6 PF15985.5 EFC42010.1 - 2.1e-10 40.8 0.2 3.8e-10 40.0 0.2 1.5 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 EFC42010.1 - 5.2e-10 39.0 0.0 1.1e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region NLPC_P60 PF00877.19 EFC42011.1 - 7.6e-07 29.1 0.1 2.6e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 NlpC/P60 family ER PF01133.17 EFC42011.1 - 1e-06 28.6 0.0 3.1e-06 27.1 0.0 1.8 1 0 0 1 1 1 1 Enhancer of rudimentary Poxvirus_B22R_N PF13169.6 EFC42012.1 - 0.021 15.3 1.3 0.045 14.3 1.3 1.5 1 0 0 1 1 1 0 Poxvirus B22R protein N-terminal NOP19 PF10863.8 EFC42012.1 - 3.5 7.4 6.7 1.5 8.7 0.1 2.6 3 0 0 3 3 3 0 Nucleolar protein 19 Ribosomal_L11_N PF03946.14 EFC42013.1 - 0.13 12.1 0.1 0.3 11.0 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11, N-terminal domain LMBR1 PF04791.16 EFC42013.1 - 5 5.9 8.1 5.8 5.7 8.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein NAD_binding_6 PF08030.12 EFC42014.1 - 1e-46 158.9 0.0 1.8e-46 158.1 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC42014.1 - 6.1e-20 71.3 0.0 1.4e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 EFC42014.1 - 5.9e-19 68.4 11.9 5.9e-19 68.4 11.9 2.0 3 0 0 3 3 3 1 Ferric reductase like transmembrane component SH3_9 PF14604.6 EFC42014.1 - 9.9e-15 54.1 0.0 1.8e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFC42014.1 - 1.7e-14 53.2 0.0 3.2e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFC42014.1 - 1.3e-08 34.4 0.0 2.4e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FAD_binding_6 PF00970.24 EFC42014.1 - 0.00082 19.7 0.0 0.011 16.0 0.0 2.6 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFC42014.1 - 0.0024 18.5 0.0 0.51 11.0 0.0 2.5 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Cu-oxidase_3 PF07732.15 EFC42015.1 - 5.6e-09 36.0 0.0 2.3e-06 27.6 0.0 2.6 2 2 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 EFC42015.1 - 2.3e-06 27.4 0.0 0.0035 17.1 0.0 2.5 3 0 0 3 3 3 2 Multicopper oxidase SNF2_N PF00176.23 EFC42016.1 - 2.5e-24 85.7 0.0 4.5e-24 84.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 EFC42016.1 - 2.3e-07 31.0 0.5 0.0007 19.6 0.0 2.7 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC42016.1 - 0.0014 18.9 0.6 0.0042 17.4 0.2 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC42016.1 - 0.037 13.8 0.1 5.3 6.8 0.0 3.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase SURF6 PF04935.12 EFC42018.1 - 1 9.1 40.1 0.17 11.7 36.1 1.7 1 1 1 2 2 2 0 Surfeit locus protein 6 SANTA PF09133.10 EFC42018.1 - 1.1 9.7 4.2 24 5.5 1.1 3.0 1 1 1 2 2 2 0 SANTA (SANT Associated) H_PPase PF03030.16 EFC42019.1 - 2.1e-251 836.2 30.3 2.5e-251 836.0 30.3 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase Big_1 PF02369.16 EFC42019.1 - 0.0012 18.8 0.2 0.056 13.4 0.0 2.7 2 0 0 2 2 2 1 Bacterial Ig-like domain (group 1) Invasin_D3 PF09134.10 EFC42019.1 - 0.018 15.3 0.4 0.058 13.7 0.2 1.9 2 0 0 2 2 2 0 Invasin, domain 3 DUF2407_C PF13373.6 EFC42019.1 - 0.058 13.6 0.6 3.4 7.9 0.0 3.4 3 0 0 3 3 3 0 DUF2407 C-terminal domain Vma12 PF11712.8 EFC42019.1 - 2 8.4 7.6 0.62 10.1 0.1 3.3 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4731 PF15875.5 EFC42019.1 - 6 7.1 5.8 2 8.6 0.3 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4731) KBP_C PF12309.8 EFC42020.1 - 9.5e-56 189.8 10.8 2.8e-55 188.3 5.3 2.4 2 0 0 2 2 2 1 KIF-1 binding protein C terminal TPR_2 PF07719.17 EFC42020.1 - 2.1e-06 27.4 0.6 0.0026 17.7 0.2 4.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42020.1 - 2.6e-05 23.9 0.3 0.001 18.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC42020.1 - 3.5e-05 23.5 0.1 0.026 14.4 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42020.1 - 5.4e-05 22.8 2.1 0.0013 18.4 0.2 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42020.1 - 0.0019 18.4 0.0 0.17 12.2 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC42020.1 - 0.067 13.6 0.0 0.33 11.4 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC42020.1 - 0.46 10.8 4.0 5.3 7.5 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_C12 PF01088.21 EFC42021.1 - 1.5e-66 224.1 0.2 3.2e-66 223.1 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DUF3781 PF12636.7 EFC42021.1 - 0.081 12.8 1.5 0.17 11.8 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3781) Es2 PF09751.9 EFC42023.1 - 1.1e-33 117.7 21.9 5.1e-28 99.0 14.4 2.2 1 1 1 2 2 2 2 Nuclear protein Es2 FAM184 PF15665.5 EFC42024.1 - 9.7e-05 22.2 35.6 9.7e-05 22.2 35.6 2.7 1 1 2 3 3 3 2 Family with sequence similarity 184, A and B Tho2 PF11262.8 EFC42024.1 - 0.0024 17.1 12.1 0.0024 17.1 12.1 3.2 1 1 2 3 3 3 2 Transcription factor/nuclear export subunit protein 2 YmaF PF12788.7 EFC42024.1 - 0.022 15.3 2.1 0.096 13.2 0.3 2.4 1 1 1 2 2 2 0 YmaF family Lectin_N PF03954.14 EFC42024.1 - 0.07 12.9 25.8 0.11 12.3 6.4 3.6 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain Inhibitor_G39P PF11417.8 EFC42024.1 - 0.07 13.7 0.4 0.32 11.5 0.2 2.2 2 0 0 2 2 2 0 Loader and inhibitor of phage G40P DUF2345 PF10106.9 EFC42024.1 - 0.25 11.2 7.0 4.1 7.3 0.2 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) DUF3747 PF12565.8 EFC42024.1 - 0.43 9.9 6.2 13 5.1 0.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3747) DUF812 PF05667.11 EFC42024.1 - 4.4 6.1 50.9 9 5.0 22.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Pkinase PF00069.25 EFC42025.1 - 5.2e-68 229.3 0.0 7.4e-68 228.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42025.1 - 7.1e-30 104.1 0.0 4e-28 98.4 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC42025.1 - 0.021 14.1 0.1 1.1 8.5 0.0 2.9 2 1 1 3 3 3 0 Kinase-like Pkinase_fungal PF17667.1 EFC42025.1 - 0.035 12.9 0.0 0.063 12.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF3246 PF11596.8 EFC42026.1 - 0.096 12.1 0.3 0.15 11.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Metallophos PF00149.28 EFC42027.1 - 2.4e-12 47.8 0.1 3.9e-12 47.1 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WD40 PF00400.32 EFC42028.1 - 2.6e-39 132.5 19.1 9e-09 35.8 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42028.1 - 1.1e-08 35.2 2.0 0.11 12.7 0.0 5.7 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFC42028.1 - 0.00023 21.2 0.1 5.6 7.1 0.0 4.1 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 EFC42028.1 - 0.0003 19.6 3.8 0.049 12.3 0.0 2.8 4 0 0 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 EFC42028.1 - 0.0034 16.8 0.0 0.11 11.7 0.0 2.5 2 0 0 2 2 2 1 WD40-like domain Frtz PF11768.8 EFC42028.1 - 0.027 12.8 0.1 5.1 5.3 0.0 3.0 3 1 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz FAM24 PF15193.6 EFC42028.1 - 0.077 13.8 0.1 0.19 12.5 0.1 1.6 1 0 0 1 1 1 0 FAM24 family REPA_OB_2 PF16900.5 EFC42028.1 - 0.089 12.7 0.2 0.46 10.4 0.1 2.1 2 0 0 2 2 2 0 Replication protein A OB domain Patatin PF01734.22 EFC42029.1 - 7.8e-18 65.4 0.0 1.4e-17 64.6 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase Homeobox_KN PF05920.11 EFC42030.1 - 5e-16 58.3 1.3 8.4e-16 57.6 0.2 2.1 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFC42030.1 - 9.8e-09 34.9 0.3 9.8e-09 34.9 0.3 2.2 2 0 0 2 2 2 1 Homeodomain Homez PF11569.8 EFC42030.1 - 0.015 14.7 0.7 0.057 12.9 0.2 2.2 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Pheromone PF08015.11 EFC42030.1 - 1.3 10.1 0.0 1.3 10.1 0.0 4.5 5 1 0 5 5 5 0 Fungal mating-type pheromone GARP PF16731.5 EFC42031.1 - 0.12 12.1 0.0 0.17 11.5 0.0 1.1 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma FTZ PF03867.14 EFC42031.1 - 0.82 9.2 5.9 1.3 8.5 5.9 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DDOST_48kD PF03345.14 EFC42032.1 - 7.2e-131 436.8 0.4 8.9e-131 436.5 0.4 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Myb_DNA-binding PF00249.31 EFC42033.1 - 3.8e-09 36.6 0.2 5.8e-09 36.0 0.2 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC42033.1 - 1.7e-05 25.0 0.2 4.6e-05 23.6 0.2 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC42033.1 - 0.0015 18.4 0.8 0.0026 17.6 0.0 1.8 2 0 0 2 2 2 1 Myb DNA-binding like Recep_L_domain PF01030.24 EFC42033.1 - 0.077 13.1 2.2 0.26 11.4 2.2 1.9 1 0 0 1 1 1 0 Receptor L domain MAPEG PF01124.18 EFC42034.1 - 3.8e-11 43.0 0.5 5e-11 42.6 0.5 1.2 1 0 0 1 1 1 1 MAPEG family 5_nucleotid PF05761.14 EFC42035.1 - 2.9e-138 461.6 8.7 5.6e-136 454.1 8.7 2.0 1 1 0 1 1 1 1 5' nucleotidase family DUF234 PF03008.14 EFC42035.1 - 0.065 13.7 0.1 3 8.4 0.0 2.5 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function HAD_2 PF13419.6 EFC42035.1 - 0.069 13.2 0.0 2.5 8.2 0.0 2.9 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Mito_carr PF00153.27 EFC42036.1 - 2.5e-12 46.6 0.1 1.1e-06 28.5 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein BCS1_N PF08740.11 EFC42037.1 - 1.3e-32 113.3 0.0 2.1e-32 112.6 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 EFC42037.1 - 9.3e-19 68.2 0.0 1.9e-18 67.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 EFC42037.1 - 2.7e-05 23.5 0.0 4.6e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFC42037.1 - 0.00012 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_6 PF12774.7 EFC42037.1 - 0.00014 20.9 0.0 0.00027 20.0 0.0 1.4 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_5 PF07728.14 EFC42037.1 - 0.00073 19.5 0.5 0.013 15.5 0.5 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC42037.1 - 0.0012 19.3 0.0 0.0027 18.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 EFC42037.1 - 0.0012 18.1 0.3 0.0024 17.1 0.0 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 EFC42037.1 - 0.0059 17.0 0.0 0.087 13.2 0.0 2.7 3 0 0 3 3 3 1 RNA helicase AAA_11 PF13086.6 EFC42037.1 - 0.0075 16.1 1.0 0.011 15.5 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFC42037.1 - 0.016 15.3 0.0 0.043 14.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 EFC42037.1 - 0.055 12.8 0.0 0.15 11.4 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 EFC42037.1 - 0.061 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EFC42037.1 - 0.08 13.5 0.1 0.48 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Enolase_like_N PF18374.1 EFC42037.1 - 0.15 11.4 0.1 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Enolase N-terminal domain-like Cytidylate_kin PF02224.18 EFC42037.1 - 0.19 11.4 0.3 0.52 10.0 0.0 1.9 3 0 0 3 3 3 0 Cytidylate kinase Pkinase PF00069.25 EFC42038.1 - 3.8e-64 216.6 0.0 4.5e-64 216.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42038.1 - 5e-33 114.5 0.0 1e-32 113.5 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC42038.1 - 0.0011 17.8 0.0 0.0092 14.8 0.0 2.0 1 1 1 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC42038.1 - 0.011 14.7 0.0 0.021 13.8 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 EFC42038.1 - 0.02 14.2 0.0 0.64 9.3 0.0 2.4 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 EFC42038.1 - 0.021 14.8 0.1 0.033 14.1 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFC42038.1 - 0.022 14.1 0.2 0.085 12.2 0.2 1.9 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MRNIP PF15749.5 EFC42039.1 - 3.6e-21 75.9 40.3 4.8e-18 65.9 29.7 3.3 2 1 0 2 2 2 1 MRN-interacting protein Zn_Tnp_IS1595 PF12760.7 EFC42039.1 - 0.032 14.2 2.0 0.057 13.4 2.0 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-MIZ PF02891.20 EFC42039.1 - 0.041 13.6 2.4 0.073 12.8 2.4 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-Sec23_Sec24 PF04810.15 EFC42039.1 - 1 9.5 4.4 2.6 8.2 4.4 1.7 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger GREB1 PF15782.5 EFC42039.1 - 1.5 5.8 14.0 1.9 5.5 14.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FAD_binding_2 PF00890.24 EFC42040.1 - 4.1e-118 395.1 2.1 5.5e-118 394.7 2.1 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 EFC42040.1 - 1.5e-40 138.2 0.1 2.9e-40 137.2 0.1 1.5 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 EFC42040.1 - 1e-05 25.0 0.2 2.2e-05 23.9 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC42040.1 - 8.4e-05 22.7 0.4 0.00022 21.4 0.4 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFC42040.1 - 0.00012 21.3 1.3 0.0039 16.3 2.0 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 EFC42040.1 - 0.00013 20.8 0.2 0.00033 19.5 0.3 1.7 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFC42040.1 - 0.00017 21.3 0.4 0.0003 20.5 0.4 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC42040.1 - 0.00034 20.0 0.7 0.0018 17.6 0.3 2.0 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 EFC42040.1 - 0.0004 19.7 0.4 0.0047 16.2 0.2 2.2 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 EFC42040.1 - 0.0033 16.5 1.8 0.0048 16.0 0.3 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein ApbA PF02558.16 EFC42040.1 - 0.055 13.1 0.9 0.14 11.8 0.9 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EFC42040.1 - 0.083 12.1 0.6 0.51 9.5 0.5 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC42040.1 - 0.09 13.4 1.0 0.2 12.2 1.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 EFC42040.1 - 4.6 6.8 4.9 1.1 8.8 0.8 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 EFC42040.1 - 6.6 6.6 6.2 2.9 7.7 0.2 2.6 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyridoxal_deC PF00282.19 EFC42041.1 - 4e-121 404.2 0.0 5.3e-121 403.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 EFC42041.1 - 0.00056 19.3 0.0 0.0038 16.5 0.0 1.9 1 1 1 2 2 2 1 Beta-eliminating lyase SepSecS PF05889.13 EFC42041.1 - 0.0064 15.2 0.0 0.0096 14.6 0.0 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_1_2 PF00155.21 EFC42041.1 - 0.028 13.6 0.1 0.31 10.2 0.0 2.0 2 0 0 2 2 2 0 Aminotransferase class I and II Raptor_N PF14538.6 EFC42042.1 - 2.1e-69 232.1 0.2 4.1e-69 231.2 0.2 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 EFC42042.1 - 3.5e-09 37.1 5.9 0.19 12.7 0.0 5.8 6 0 0 6 6 6 3 WD domain, G-beta repeat HEAT PF02985.22 EFC42042.1 - 1.5e-07 31.0 2.4 0.04 14.2 0.0 5.5 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EFC42042.1 - 1.8e-05 24.9 2.3 0.00092 19.3 0.1 3.4 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC42042.1 - 4.4e-05 23.8 0.0 0.033 14.6 0.0 3.6 2 1 2 4 4 4 2 HEAT repeats V-ATPase_H_C PF11698.8 EFC42042.1 - 0.002 18.2 0.0 0.006 16.7 0.0 1.8 1 0 0 1 1 1 1 V-ATPase subunit H RTP1_C1 PF10363.9 EFC42042.1 - 0.018 15.2 0.0 0.12 12.6 0.0 2.2 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 EFC42042.1 - 0.019 13.6 0.2 1.5 7.3 0.2 2.7 1 1 1 2 2 2 0 Adaptin N terminal region Rad51 PF08423.11 EFC42043.1 - 0.0017 17.7 0.3 0.0025 17.1 0.3 1.4 1 1 0 1 1 1 1 Rad51 Nup88 PF10168.9 EFC42043.1 - 0.0085 14.0 2.6 0.072 10.9 0.9 2.0 2 0 0 2 2 2 2 Nuclear pore component tRNA-synt_2 PF00152.20 EFC42045.1 - 1.2e-77 261.1 0.1 2.3e-77 260.2 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFC42045.1 - 1.1e-09 38.2 0.6 2.1e-09 37.2 0.6 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFC42045.1 - 0.0051 16.3 0.2 1.3 8.4 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DctP PF03480.13 EFC42045.1 - 0.18 11.1 5.0 0.49 9.7 5.0 1.6 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 LRR_6 PF13516.6 EFC42047.1 - 9.8e-14 50.2 40.8 0.00038 20.3 0.2 9.6 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.7 EFC42047.1 - 4.4e-07 30.1 49.0 6.4e-06 26.4 3.2 6.9 3 2 5 9 9 9 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC42047.1 - 6e-06 25.9 43.8 0.00031 20.5 2.8 5.8 2 1 4 6 6 6 3 Leucine rich repeat F-box PF00646.33 EFC42047.1 - 4.8e-05 23.1 0.0 0.00016 21.5 0.0 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC42047.1 - 0.0001 22.1 2.3 0.00036 20.4 0.2 2.3 2 0 0 2 2 2 1 F-box-like LRR_2 PF07723.13 EFC42047.1 - 0.57 10.9 6.4 15 6.5 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat zf-CW PF07496.15 EFC42047.1 - 0.61 10.2 4.2 50 4.0 0.0 2.5 1 1 1 2 2 2 0 CW-type Zinc Finger LRR_1 PF00560.33 EFC42047.1 - 0.9 10.3 33.3 5.5 7.9 0.7 8.7 7 2 0 7 7 7 0 Leucine Rich Repeat Viral_env_E26 PF11050.8 EFC42047.1 - 2.3 7.6 7.5 2.2 7.6 0.3 2.9 2 1 1 3 3 3 0 Virus envelope protein E26 Guanylate_cyc PF00211.20 EFC42048.1 - 0.00047 19.8 0.5 0.00084 19.0 0.5 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain ASFV_J13L PF05568.11 EFC42048.1 - 0.032 14.0 1.4 0.069 12.9 1.4 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein DNA_pol_phi PF04931.13 EFC42050.1 - 8.7 4.3 10.7 18 3.3 10.7 1.5 1 0 0 1 1 1 0 DNA polymerase phi Plant_NMP1 PF06694.11 EFC42051.1 - 1.3e-07 31.1 1.4 3.3e-07 29.7 0.3 1.9 1 1 0 2 2 2 1 Plant nuclear matrix protein 1 (NMP1) PX PF00787.24 EFC42051.1 - 3.7e-05 23.7 4.3 3.7e-05 23.7 4.3 3.6 4 0 0 4 4 4 1 PX domain FliS PF02561.14 EFC42051.1 - 0.00085 19.6 2.5 0.012 15.8 0.1 3.0 2 1 0 3 3 3 1 Flagellar protein FliS Phage_integr_3 PF16795.5 EFC42051.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Archaeal phage integrase Plasmod_dom_1 PF09715.10 EFC42051.1 - 0.43 10.7 8.9 3.5 7.8 1.4 3.7 3 1 0 3 3 3 0 Plasmodium protein of unknown function (Plasmod_dom_1) Myb_DNA-binding PF00249.31 EFC42052.1 - 6e-27 93.6 1.2 3.7e-11 43.0 0.1 3.8 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC42052.1 - 2.4e-11 43.7 7.4 3.7e-06 27.1 0.1 3.7 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC42052.1 - 5.5e-09 35.8 27.8 0.00061 19.6 0.2 4.5 4 0 0 4 4 4 3 Myb DNA-binding like CCDC-167 PF15188.6 EFC42052.1 - 0.13 12.6 2.1 0.81 10.1 2.1 2.5 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF2652 PF10851.8 EFC42052.1 - 4.6 7.4 6.6 2.5 8.3 0.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2652) HEAT_2 PF13646.6 EFC42053.1 - 2.7e-26 91.8 1.5 4.7e-12 46.1 0.3 2.8 2 1 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 EFC42053.1 - 4.7e-18 64.0 0.0 0.0032 18.0 0.0 6.0 6 1 0 6 6 6 4 PBS lyase HEAT-like repeat HEAT PF02985.22 EFC42053.1 - 3.6e-05 23.7 1.8 1.8 9.1 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Arm PF00514.23 EFC42053.1 - 6.3e-05 22.9 0.3 0.03 14.4 0.0 3.1 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC42053.1 - 0.00061 20.2 0.7 1.1 9.8 0.0 3.7 5 1 1 6 6 6 2 HEAT-like repeat Peptidase_S78 PF04586.17 EFC42053.1 - 0.002 18.3 0.1 0.012 15.8 0.0 2.3 3 0 0 3 3 3 1 Caudovirus prohead serine protease KilA-N PF04383.13 EFC42054.1 - 0.11 12.4 0.7 0.31 10.9 0.7 1.7 1 0 0 1 1 1 0 KilA-N domain EGF_2 PF07974.13 EFC42056.1 - 1e-164 534.4 1289.2 5e-06 26.8 4.9 84.9 82 4 1 83 83 83 72 EGF-like domain EGF PF00008.27 EFC42056.1 - 0.00095 19.4 4.0 0.00095 19.4 4.0 74.3 74 2 0 74 74 74 37 EGF-like domain START PF01852.19 EFC42056.1 - 0.0057 16.1 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 START domain FrhB_FdhB_N PF04422.13 EFC42056.1 - 0.089 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term NTPase_1 PF03266.15 EFC42057.1 - 2e-06 27.8 1.5 0.0019 18.2 0.2 2.3 1 1 0 2 2 2 2 NTPase AAA_16 PF13191.6 EFC42057.1 - 0.0013 19.2 0.2 0.0045 17.4 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC42057.1 - 0.0069 16.7 0.8 0.1 12.9 0.8 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC42057.1 - 0.031 14.7 0.7 0.37 11.2 0.7 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 EFC42057.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EFC42057.1 - 0.19 12.1 1.4 0.91 9.9 1.4 1.9 1 1 0 1 1 1 0 AAA domain Peptidase_C26 PF07722.13 EFC42059.1 - 0.061 13.1 0.0 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase C26 Nexin_C PF08628.12 EFC42059.1 - 0.15 12.6 0.2 1.3 9.6 0.0 2.0 1 1 1 2 2 2 0 Sorting nexin C terminal TB2_DP1_HVA22 PF03134.19 EFC42060.1 - 2.4e-25 88.3 8.5 2.4e-25 88.3 8.5 2.7 3 0 0 3 3 3 1 TB2/DP1, HVA22 family Zn_clus PF00172.18 EFC42060.1 - 1.9e-09 37.5 12.7 3.5e-09 36.6 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4116 PF13475.6 EFC42061.1 - 2.9e-23 81.3 3.7 3e-11 42.9 0.0 4.5 3 1 2 5 5 5 4 Domain of unknown function (DUF4116) eIF3_N PF09440.10 EFC42061.1 - 0.0087 16.5 0.1 0.049 14.1 0.0 2.3 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain F-box PF00646.33 EFC42061.1 - 0.024 14.5 0.2 0.098 12.6 0.2 2.1 1 0 0 1 1 1 0 F-box domain F-box-like_2 PF13013.6 EFC42061.1 - 0.049 13.6 0.1 0.22 11.5 0.1 2.2 2 0 0 2 2 2 0 F-box-like domain F-box-like PF12937.7 EFC42061.1 - 0.36 10.8 2.2 0.49 10.3 0.1 2.3 2 0 0 2 2 2 0 F-box-like PARP_regulatory PF01358.18 EFC42062.1 - 9.6e-23 80.5 0.3 2e-22 79.4 0.3 1.5 1 0 0 1 1 1 1 Poly A polymerase regulatory subunit Zn_clus PF00172.18 EFC42063.1 - 0.00012 22.1 13.2 0.00028 20.9 13.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNase_T PF00929.24 EFC42064.1 - 2e-11 44.7 1.6 3.7e-11 43.9 0.2 2.1 2 0 0 2 2 2 1 Exonuclease DUF5051 PF16473.5 EFC42064.1 - 0.0011 19.0 0.1 0.0023 17.9 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like RQC PF09382.10 EFC42066.1 - 0.061 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 RQC domain D123 PF07065.14 EFC42069.1 - 3.1e-18 66.0 4.2 5.1e-17 62.0 3.6 2.2 1 1 0 1 1 1 1 D123 WH2 PF02205.20 EFC42069.1 - 0.00026 20.7 0.1 0.00053 19.7 0.1 1.5 1 0 0 1 1 1 1 WH2 motif R2K_2 PF18299.1 EFC42069.1 - 0.032 14.1 0.0 0.064 13.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 MBOAT PF03062.19 EFC42070.1 - 3.4e-18 66.1 24.2 3.4e-18 66.1 24.2 1.6 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Gly_kinase PF02595.15 EFC42071.1 - 4e-87 292.6 0.0 4.9e-87 292.3 0.0 1.0 1 0 0 1 1 1 1 Glycerate kinase family Ras PF00071.22 EFC42072.1 - 8.5e-16 58.0 0.0 1.5e-15 57.2 0.0 1.4 1 1 0 1 1 1 1 Ras family C2 PF00168.30 EFC42073.1 - 7.5e-26 90.4 0.4 1.1e-25 89.9 0.4 1.2 1 0 0 1 1 1 1 C2 domain tRNA-synt_2_TM PF16995.5 EFC42074.1 - 0.2 11.3 0.1 0.28 10.8 0.1 1.1 1 0 0 1 1 1 0 Transmembrane region of lysyl-tRNA synthetase Peptidase_S9 PF00326.21 EFC42075.1 - 2e-41 141.8 0.0 3.1e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 EFC42075.1 - 3.3e-09 36.6 0.0 1.8e-08 34.2 0.0 2.1 2 1 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 EFC42075.1 - 1.7e-08 34.0 0.0 0.0014 17.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 EFC42075.1 - 0.00017 21.3 0.0 0.059 13.0 0.0 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 EFC42075.1 - 0.0017 17.1 0.1 0.029 13.0 0.1 2.4 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 EFC42075.1 - 0.0034 17.1 0.7 0.55 9.8 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold YfmQ PF10787.9 EFC42075.1 - 0.0062 16.3 0.3 0.018 14.8 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein from bacillus cereus group PD40 PF07676.12 EFC42075.1 - 0.02 14.8 0.9 0.93 9.5 0.4 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat FSH1 PF03959.13 EFC42075.1 - 0.033 13.9 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) COesterase PF00135.28 EFC42075.1 - 0.054 12.4 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 Carboxylesterase family Abhydrolase_3 PF07859.13 EFC42075.1 - 0.1 12.4 0.0 0.35 10.7 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Esterase_phd PF10503.9 EFC42075.1 - 0.15 11.6 0.0 1.1 8.7 0.0 2.0 1 1 0 1 1 1 0 Esterase PHB depolymerase TAF4 PF05236.14 EFC42076.1 - 2.4e-05 24.3 3.5 2.4e-05 24.3 3.5 1.5 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family LRR_6 PF13516.6 EFC42076.1 - 0.031 14.3 2.2 4.2 7.7 0.0 3.7 3 0 0 3 3 3 0 Leucine Rich repeat RCC1 PF00415.18 EFC42078.1 - 8.4e-48 160.8 19.6 3e-08 34.2 0.2 9.3 8 2 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC42078.1 - 7.1e-36 121.3 40.1 4.9e-08 32.6 1.0 7.9 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RGS PF00615.19 EFC42078.1 - 2.6e-15 56.7 5.0 2.6e-15 56.7 5.0 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain CHASE4 PF05228.13 EFC42078.1 - 0.0044 17.3 0.1 0.01 16.1 0.1 1.7 1 0 0 1 1 1 1 CHASE4 domain HAMP PF00672.25 EFC42078.1 - 0.0078 16.6 0.0 0.016 15.5 0.0 1.6 1 0 0 1 1 1 1 HAMP domain P-mevalo_kinase PF04275.14 EFC42078.1 - 0.085 12.8 2.2 0.77 9.7 2.3 2.5 2 0 0 2 2 2 0 Phosphomevalonate kinase HTH_ParB PF17762.1 EFC42078.1 - 0.14 12.0 0.1 0.51 10.2 0.1 2.0 1 0 0 1 1 1 0 HTH domain found in ParB protein DUF948 PF06103.11 EFC42078.1 - 0.15 12.4 6.0 0.61 10.4 1.7 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Microtub_bd PF16796.5 EFC42078.1 - 0.51 10.3 6.1 1.1 9.2 4.4 2.4 2 0 0 2 2 2 0 Microtubule binding SPASM PF13186.6 EFC42078.1 - 4.4 7.9 10.8 1.9 9.1 0.2 4.3 4 0 0 4 4 4 0 Iron-sulfur cluster-binding domain ABC_membrane PF00664.23 EFC42079.1 - 2.6e-69 233.9 19.6 3.6e-69 233.5 19.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC42079.1 - 6.3e-30 104.5 0.0 6.3e-30 104.5 0.0 2.0 2 1 0 2 2 1 1 ABC transporter AAA_30 PF13604.6 EFC42079.1 - 0.0087 15.8 0.0 0.15 11.8 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 EFC42079.1 - 0.011 16.0 1.8 0.064 13.5 0.1 2.9 3 1 0 3 3 3 0 AAA domain TniB PF05621.11 EFC42079.1 - 0.015 14.7 0.1 2.8 7.3 0.1 2.3 2 0 0 2 2 2 0 Bacterial TniB protein ABC_membrane_3 PF13748.6 EFC42079.1 - 0.017 14.4 5.2 0.043 13.0 5.2 1.7 1 1 0 1 1 1 0 ABC transporter transmembrane region AAA_5 PF07728.14 EFC42079.1 - 0.025 14.6 0.1 1.7 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 EFC42079.1 - 0.025 15.0 0.4 0.5 10.8 0.4 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC42079.1 - 0.027 14.9 0.1 0.13 12.6 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.15 EFC42079.1 - 0.061 13.2 0.3 3.8 7.4 0.0 2.4 2 0 0 2 2 2 0 NTPase UPF0172 PF03665.13 EFC42079.1 - 0.17 11.9 4.0 0.42 10.6 4.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Pribosyltran PF00156.27 EFC42080.1 - 1.5e-05 24.5 0.0 2.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 EFC42080.1 - 0.032 13.7 0.0 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 Phosphoribosyl transferase DUF4116 PF13475.6 EFC42081.1 - 1.5e-106 348.0 0.1 1.1e-19 69.9 0.0 5.7 2 2 5 7 7 7 7 Domain of unknown function (DUF4116) DUF1667 PF07892.11 EFC42081.1 - 4.5e-05 23.4 0.2 1.5 8.9 0.0 4.6 1 1 4 5 5 5 1 Protein of unknown function (DUF1667) DUF3993 PF13158.6 EFC42081.1 - 0.0083 16.3 1.2 1.8 8.8 0.1 2.8 1 1 3 4 4 4 2 Protein of unknown function (DUF3993) PAS_6 PF08348.11 EFC42081.1 - 0.014 15.2 1.4 0.86 9.5 0.0 3.7 1 1 1 3 3 3 0 YheO-like PAS domain PhnJ PF06007.11 EFC42081.1 - 0.048 12.7 0.0 4.4 6.2 0.0 2.3 1 1 1 2 2 2 0 Phosphonate metabolism protein PhnJ His_biosynth PF00977.21 EFC42081.1 - 0.069 12.6 0.0 0.76 9.2 0.0 2.5 2 1 1 3 3 3 0 Histidine biosynthesis protein SUIM_assoc PF16619.5 EFC42081.1 - 0.17 12.0 0.4 92 3.2 0.0 3.8 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 NES_C_h PF18208.1 EFC42081.1 - 1.1 9.5 7.0 17 5.7 0.1 3.4 2 1 2 4 4 4 0 Nicking enzyme C-terminal middle helical domain TAL_effector PF03377.13 EFC42081.1 - 1.5 9.2 4.1 1e+02 3.3 0.1 4.1 4 1 0 4 4 4 0 TAL effector repeat RGS PF00615.19 EFC42082.1 - 0.00039 20.7 3.0 0.05 13.9 1.5 3.0 2 1 0 2 2 2 1 Regulator of G protein signaling domain Wzy_C PF04932.15 EFC42082.1 - 0.03 13.9 0.0 0.4 10.3 0.0 2.2 2 0 0 2 2 2 0 O-Antigen ligase POM121 PF15229.6 EFC42082.1 - 0.068 12.8 4.5 0.15 11.6 4.5 1.5 1 0 0 1 1 1 0 POM121 family DUF5367 PF17329.2 EFC42082.1 - 0.38 10.9 3.8 3.4 7.9 1.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5367) Baculo_11_kDa PF06143.11 EFC42082.1 - 7.6 6.2 9.2 4 7.1 0.4 3.0 2 0 0 2 2 2 0 Baculovirus 11 kDa family ADP_ribosyl_GH PF03747.14 EFC42083.1 - 6.9e-41 140.9 0.6 8.8e-41 140.5 0.6 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase ABC_tran_CTD PF16326.5 EFC42083.1 - 0.028 14.7 3.0 0.079 13.2 3.0 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain LysE PF01810.18 EFC42085.1 - 0.051 13.0 0.1 0.092 12.2 0.1 1.3 1 0 0 1 1 1 0 LysE type translocator SPAN-X PF07458.12 EFC42085.1 - 0.072 13.6 4.8 0.18 12.3 4.8 1.7 1 0 0 1 1 1 0 Sperm protein associated with nucleus, mapped to X chromosome RXT2_N PF08595.11 EFC42086.1 - 0.091 12.8 0.1 0.091 12.8 0.1 4.4 1 1 3 4 4 4 0 RXT2-like, N-terminal His_Phos_1 PF00300.22 EFC42087.1 - 0.00029 20.6 0.0 0.51 10.0 0.0 3.2 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) EGF_2 PF07974.13 EFC42088.1 - 4.8e-40 135.6 286.4 0.00019 21.7 9.0 18.1 18 0 0 18 18 18 16 EGF-like domain NHL PF01436.21 EFC42088.1 - 1.3e-13 50.2 0.2 0.0049 16.9 0.0 6.0 5 0 0 5 5 5 3 NHL repeat RGS PF00615.19 EFC42088.1 - 1.7e-10 41.2 5.6 1.7e-10 41.2 5.6 2.6 2 1 1 3 3 3 1 Regulator of G protein signaling domain Trypan_PARP PF05887.11 EFC42089.1 - 1.7e-06 28.0 104.7 0.016 15.2 36.4 3.1 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) F-box PF00646.33 EFC42090.1 - 0.00019 21.3 0.0 0.00039 20.2 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC42090.1 - 0.0007 19.4 0.1 0.002 18.0 0.0 1.8 2 0 0 2 2 2 1 F-box-like Response_reg PF00072.24 EFC42091.1 - 2.7e-19 69.4 0.2 3.7e-19 69.0 0.2 1.2 1 0 0 1 1 1 1 Response regulator receiver domain Kelch_4 PF13418.6 EFC42092.1 - 3.3e-28 97.4 0.9 2.3e-11 43.5 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC42092.1 - 1.6e-21 75.8 4.2 7.6e-07 29.0 0.1 5.7 5 0 0 5 5 5 3 Kelch motif BTB PF00651.31 EFC42092.1 - 3.9e-21 75.4 1.7 2.4e-09 37.4 0.0 3.3 2 1 0 2 2 2 2 BTB/POZ domain Kelch_1 PF01344.25 EFC42092.1 - 1.9e-19 69.0 1.5 5.1e-09 35.6 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EFC42092.1 - 3.2e-19 68.7 2.3 1.6e-06 28.2 0.0 5.9 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC42092.1 - 7.3e-17 61.0 6.9 0.00031 20.9 0.0 5.0 4 1 1 5 5 5 4 Kelch motif Kelch_2 PF07646.15 EFC42092.1 - 5e-12 45.3 4.3 4.7e-05 23.2 0.1 5.2 5 0 0 5 5 5 2 Kelch motif YL1 PF05764.13 EFC42092.1 - 0.00041 20.6 17.3 0.00068 19.8 17.3 1.3 1 0 0 1 1 1 1 YL1 nuclear protein BACK PF07707.15 EFC42092.1 - 0.0062 16.6 0.1 0.043 13.9 0.0 2.4 2 0 0 2 2 2 1 BTB And C-terminal Kelch Nop14 PF04147.12 EFC42092.1 - 0.22 9.7 17.8 0.33 9.1 17.8 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EFC42092.1 - 2.4 6.4 17.9 3.5 5.8 17.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PYST-C1 PF09690.10 EFC42093.1 - 0.0007 19.3 2.7 0.0007 19.3 2.7 2.9 3 1 0 3 3 3 1 Plasmodium yoelii subtelomeric region (PYST-C1) MFS_1 PF07690.16 EFC42094.1 - 4.2e-21 75.2 46.6 9.5e-14 51.1 19.3 3.0 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC42094.1 - 4.7e-21 75.2 35.3 5.2e-17 61.8 11.9 4.0 2 2 1 3 3 3 3 Sugar (and other) transporter FAM176 PF14851.6 EFC42094.1 - 1.2 8.8 6.6 2.6 7.7 0.0 2.5 2 0 0 2 2 2 0 FAM176 family Methyltransf_32 PF13679.6 EFC42095.1 - 2.3e-23 82.9 7.7 4.3e-23 82.0 7.7 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC42095.1 - 0.0045 16.8 1.2 0.016 15.0 1.2 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC42095.1 - 0.01 16.5 0.0 0.048 14.4 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFC42095.1 - 0.015 15.9 0.1 0.41 11.3 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFC42095.1 - 0.018 14.9 0.0 0.04 13.8 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Aida_N PF08910.10 EFC42095.1 - 0.021 15.2 2.4 0.042 14.2 1.1 2.2 2 0 0 2 2 2 0 Aida N-terminus Methyltransf_12 PF08242.12 EFC42095.1 - 0.039 14.7 0.1 0.12 13.1 0.1 1.9 1 0 0 1 1 1 0 Methyltransferase domain STAT_alpha PF01017.20 EFC42095.1 - 0.04 13.8 5.3 0.15 11.9 1.9 2.5 2 0 0 2 2 2 0 STAT protein, all-alpha domain 3HCDH_N PF02737.18 EFC42095.1 - 0.046 13.6 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PEX11 PF05648.14 EFC42095.1 - 0.096 12.1 1.2 0.49 9.8 0.0 2.2 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DUF1525 PF07511.11 EFC42095.1 - 0.38 10.9 3.6 0.15 12.3 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1525) Pkinase PF00069.25 EFC42096.1 - 1.4e-46 159.0 0.0 2.3e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42096.1 - 3.4e-29 101.9 0.0 4.9e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC42096.1 - 6.5e-14 52.0 71.4 0.00013 22.2 10.6 5.2 5 0 0 5 5 4 4 EGF-like domain NHL PF01436.21 EFC42096.1 - 9.4e-07 28.6 0.0 0.0069 16.4 0.0 3.7 3 0 0 3 3 3 2 NHL repeat Pkinase_fungal PF17667.1 EFC42096.1 - 3.6e-06 26.0 0.5 7.8e-06 24.9 0.5 1.5 1 1 0 1 1 1 1 Fungal protein kinase TMEM51 PF15345.6 EFC42096.1 - 0.0026 17.6 0.5 0.0046 16.8 0.5 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 Kdo PF06293.14 EFC42096.1 - 0.013 14.8 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Stevor PF17410.2 EFC42096.1 - 0.026 14.1 0.1 0.11 12.0 0.0 2.0 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame S_4TM PF18159.1 EFC42096.1 - 0.077 12.3 0.0 0.18 11.1 0.0 1.5 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain Carbam_trans_C PF16861.5 EFC42096.1 - 0.093 12.3 0.9 0.17 11.5 0.9 1.3 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus DUF2140 PF09911.9 EFC42096.1 - 0.11 12.0 0.6 0.21 11.1 0.3 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) SieB PF14163.6 EFC42096.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B APH PF01636.23 EFC42096.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF5325 PF17259.2 EFC42096.1 - 0.16 11.9 1.1 0.32 10.9 1.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5325) Miga PF10265.9 EFC42096.1 - 0.18 10.8 0.5 0.27 10.1 0.5 1.2 1 0 0 1 1 1 0 Mitoguardin RGS PF00615.19 EFC42098.1 - 4.8e-17 62.3 4.7 4.8e-17 62.3 4.7 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain cobW PF02492.19 EFC42099.1 - 2.9e-59 199.6 0.2 4.1e-59 199.1 0.2 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFC42099.1 - 8.5e-15 54.5 0.0 1.8e-14 53.4 0.0 1.6 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EFC42099.1 - 0.00038 20.4 0.2 1 9.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC42099.1 - 0.0045 16.6 2.3 0.016 14.8 2.3 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 EFC42099.1 - 0.0068 16.7 0.1 0.024 14.9 0.0 1.9 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 EFC42099.1 - 0.026 13.6 0.0 0.062 12.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EFC42099.1 - 0.034 14.2 0.3 0.24 11.5 0.3 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 EFC42099.1 - 0.039 14.2 0.1 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 EFC42099.1 - 0.04 13.8 0.0 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 EFC42099.1 - 0.077 13.5 0.3 0.52 10.8 0.0 2.4 3 0 0 3 3 3 0 ABC transporter ATPase_2 PF01637.18 EFC42099.1 - 0.12 12.3 2.2 0.19 11.6 0.1 2.3 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EFC42099.1 - 0.14 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 EFC42099.1 - 0.18 11.6 0.1 0.42 10.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFC42099.1 - 5.7 7.4 10.1 73 3.8 10.1 2.3 1 1 0 1 1 1 0 AAA domain ESCRT-II PF05871.12 EFC42101.1 - 3.1e-46 157.1 0.2 4.2e-46 156.7 0.2 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit DUF4972 PF16342.5 EFC42102.1 - 0.0099 15.6 0.2 0.011 15.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4972) Peptidase_M3_N PF08439.10 EFC42102.1 - 0.081 13.2 1.5 0.09 13.1 0.6 1.5 2 0 0 2 2 2 0 Oligopeptidase F WD40 PF00400.32 EFC42103.1 - 6.3e-18 64.8 8.0 6.6e-08 33.1 1.0 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42103.1 - 3.7e-05 23.9 0.2 0.041 14.2 0.1 3.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC42103.1 - 0.00095 18.6 0.7 0.11 11.8 0.1 2.4 2 1 1 3 3 3 2 WD40-like domain BBS2_Mid PF14783.6 EFC42103.1 - 0.0018 18.3 0.1 0.13 12.3 0.0 3.1 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region DUF4116 PF13475.6 EFC42104.1 - 9.8e-120 390.2 22.4 3.4e-18 65.1 0.0 12.3 7 3 3 12 12 12 12 Domain of unknown function (DUF4116) FtsX_ECD PF18075.1 EFC42104.1 - 0.077 13.6 0.2 7.5 7.2 0.0 3.0 2 0 0 2 2 2 0 FtsX extracellular domain DUF1667 PF07892.11 EFC42104.1 - 0.1 12.7 0.1 19 5.4 0.0 3.9 3 1 2 5 5 5 0 Protein of unknown function (DUF1667) NOA36 PF06524.12 EFC42104.1 - 1.8 7.8 7.8 2.9 7.1 7.8 1.3 1 0 0 1 1 1 0 NOA36 protein adh_short PF00106.25 EFC42106.1 - 5.3e-17 61.9 0.0 2.2e-12 46.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC42106.1 - 3.9e-12 46.2 0.0 3e-09 36.8 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase PP2C PF00481.21 EFC42107.1 - 1.7e-55 188.5 0.1 1.9e-55 188.3 0.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C TolB_like PF15869.5 EFC42107.1 - 0.012 14.9 0.1 0.015 14.6 0.1 1.3 1 0 0 1 1 1 0 TolB-like 6-blade propeller-like SpoIIE PF07228.12 EFC42107.1 - 0.018 14.9 0.1 5.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EFC42107.1 - 0.023 14.3 0.0 0.039 13.6 0.0 1.4 1 1 0 1 1 1 0 Protein phosphatase 2C Pkinase PF00069.25 EFC42108.1 - 4.6e-57 193.4 0.0 3.7e-55 187.1 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42108.1 - 3.2e-24 85.6 0.1 5.1e-24 85.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 EFC42108.1 - 0.00047 19.8 0.2 0.35 10.4 0.0 2.5 2 1 0 2 2 2 2 Choline/ethanolamine kinase Kdo PF06293.14 EFC42108.1 - 0.0008 18.8 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC42108.1 - 0.23 11.3 0.0 0.37 10.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ion_trans_2 PF07885.16 EFC42109.1 - 3.7e-07 30.0 3.2 5.7e-07 29.4 3.2 1.3 1 0 0 1 1 1 1 Ion channel DUF4179 PF13786.6 EFC42109.1 - 0.034 14.6 0.0 0.082 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Shisa PF13908.6 EFC42110.1 - 0.042 14.1 1.3 0.066 13.4 0.1 2.0 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator BRCT PF00533.26 EFC42110.1 - 0.066 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain NAD_binding_6 PF08030.12 EFC42111.1 - 1.7e-45 154.9 0.0 3.2e-45 154.1 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC42111.1 - 2.5e-19 69.4 0.0 1.9e-18 66.5 0.0 2.4 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 EFC42111.1 - 9.2e-19 67.8 12.3 1.8e-18 66.8 12.3 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component SH3_9 PF14604.6 EFC42111.1 - 2e-15 56.4 0.0 4.2e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFC42111.1 - 4.8e-15 54.9 0.0 1e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 EFC42111.1 - 5.4e-09 35.6 0.0 1.1e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain NAD_binding_1 PF00175.21 EFC42111.1 - 0.0087 16.7 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFC42111.1 - 0.11 12.8 0.0 0.57 10.6 0.0 2.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain YcaO PF02624.16 EFC42111.1 - 0.17 11.1 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 YcaO cyclodehydratase, ATP-ad Mg2+-binding DBR1 PF05011.13 EFC42112.1 - 3.4e-20 72.9 0.3 2e-19 70.4 0.3 2.2 1 1 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain DUF536 PF04394.14 EFC42112.1 - 0.011 15.6 3.4 0.052 13.4 3.4 2.3 1 0 0 1 1 1 0 Protein of unknown function, DUF536 PB1 PF00564.24 EFC42112.1 - 0.07 13.1 0.2 0.6 10.1 0.6 2.3 2 0 0 2 2 2 0 PB1 domain PFK PF00365.20 EFC42112.1 - 0.18 11.1 0.0 0.35 10.2 0.0 1.4 1 0 0 1 1 1 0 Phosphofructokinase LRR_6 PF13516.6 EFC42114.1 - 3.8e-26 88.9 32.5 4.4e-06 26.3 0.7 8.9 9 0 0 9 9 9 6 Leucine Rich repeat LRR_8 PF13855.6 EFC42114.1 - 2.8e-13 49.4 39.7 2.2e-06 27.3 5.6 6.2 3 1 3 7 7 7 4 Leucine rich repeat LRR_4 PF12799.7 EFC42114.1 - 1.5e-10 41.2 58.4 8e-05 22.9 4.0 7.9 2 2 6 9 9 9 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42114.1 - 4.9e-10 38.5 19.5 0.87 10.4 0.0 9.6 10 0 0 10 10 10 3 Leucine Rich Repeat Pentapeptide_3 PF13576.6 EFC42114.1 - 9.4e-06 25.7 5.4 1.9e-05 24.7 5.4 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 EFC42114.1 - 1.2e-05 25.4 11.0 1.6e-05 25.0 6.1 2.9 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 EFC42114.1 - 0.00017 21.1 4.5 0.0003 20.3 0.7 2.9 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) Abi_C PF14355.6 EFC42114.1 - 3.3 7.9 4.9 17 5.6 0.1 3.9 3 2 1 5 5 5 0 Abortive infection C-terminus FumaraseC_C PF10415.9 EFC42114.1 - 6 7.4 9.3 35 4.9 0.0 4.9 4 1 1 5 5 5 0 Fumarase C C-terminus Ependymin PF00811.18 EFC42115.1 - 0.19 12.0 4.4 0.14 12.4 2.1 2.0 2 1 0 2 2 2 0 Ependymin ASC PF00858.24 EFC42116.1 - 3.4e-09 36.2 5.2 0.0013 17.8 1.0 3.0 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel Peptidase_C1 PF00112.23 EFC42117.1 - 5.7e-49 167.2 4.5 9.6e-49 166.4 4.5 1.4 1 0 0 1 1 1 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFC42117.1 - 1.7e-20 73.5 0.1 5.9e-20 71.7 0.1 2.0 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EFC42117.1 - 6e-05 22.0 1.6 0.0022 16.8 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family ICAM_N PF03921.14 EFC42117.1 - 0.14 11.8 0.5 0.38 10.5 0.1 1.9 2 0 0 2 2 2 0 Intercellular adhesion molecule (ICAM), N-terminal domain F-box-like PF12937.7 EFC42118.1 - 2.8e-05 23.9 0.5 0.0001 22.1 0.1 2.1 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 EFC42118.1 - 0.011 16.1 2.2 6.7 7.3 0.1 3.4 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC42118.1 - 0.028 14.3 1.3 0.19 11.6 0.1 2.6 3 0 0 3 3 3 0 F-box domain p450 PF00067.22 EFC42119.1 - 4.8e-67 226.7 0.0 7e-67 226.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Mak10 PF04112.13 EFC42119.1 - 0.086 12.4 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase GST_N_2 PF13409.6 EFC42120.1 - 1.1e-14 54.4 0.0 4.1e-14 52.6 0.0 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC42120.1 - 5.9e-11 42.2 0.0 1.2e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC42120.1 - 1.3e-07 31.9 0.0 1.9e-06 28.2 0.1 2.6 3 1 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 EFC42120.1 - 9.2e-06 26.2 0.0 2e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC42120.1 - 0.00045 20.5 0.2 0.021 15.2 0.1 3.0 2 1 1 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC42120.1 - 0.0024 18.1 0.1 0.0095 16.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Kinesin PF00225.23 EFC42122.1 - 2.7e-113 378.3 0.3 2.7e-113 378.3 0.3 2.3 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC42122.1 - 7e-27 94.2 0.0 7e-27 94.2 0.0 2.8 2 1 1 3 3 3 1 Microtubule binding SH3BGR PF04908.15 EFC42122.1 - 0.042 14.0 0.0 0.32 11.2 0.0 2.6 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein DUF305 PF03713.13 EFC42122.1 - 0.2 11.8 3.6 1.7 8.8 3.6 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF305) DUF932 PF06067.11 EFC42122.1 - 0.5 10.1 5.0 0.58 9.9 3.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF932) TPR_2 PF07719.17 EFC42123.1 - 2.1e-12 46.1 0.5 0.0034 17.4 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42123.1 - 3.8e-10 39.1 3.9 0.005 16.6 0.4 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat F-box-like PF12937.7 EFC42123.1 - 1.9e-05 24.5 0.3 3.8e-05 23.5 0.3 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC42123.1 - 9.6e-05 22.2 0.9 0.0002 21.1 0.9 1.5 1 0 0 1 1 1 1 F-box domain TPR_11 PF13414.6 EFC42123.1 - 0.00061 19.4 5.8 0.015 15.0 0.0 4.8 5 1 1 6 6 6 1 TPR repeat TPR_7 PF13176.6 EFC42123.1 - 0.0031 17.4 0.2 17 5.7 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC42123.1 - 0.015 14.7 0.0 0.31 10.5 0.0 2.5 2 0 0 2 2 2 0 SHNi-TPR MIT PF04212.18 EFC42123.1 - 0.016 15.3 2.6 6.9 6.8 0.0 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 EFC42123.1 - 0.018 15.2 1.8 0.86 10.0 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42123.1 - 0.027 14.7 0.9 2 8.8 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat F-box_4 PF15966.5 EFC42123.1 - 0.046 13.6 0.6 0.087 12.7 0.0 1.8 2 0 0 2 2 2 0 F-box DUF769 PF05590.11 EFC42123.1 - 0.059 12.8 0.1 5 6.5 0.1 2.3 2 0 0 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) TPR_14 PF13428.6 EFC42123.1 - 0.17 12.8 0.0 1.3e+02 3.8 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF3698 PF12479.8 EFC42123.1 - 9.7 6.8 8.0 17 6.0 1.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3698) Guanylate_cyc PF00211.20 EFC42124.1 - 3.8e-54 183.1 0.3 7.5e-54 182.1 0.3 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC42124.1 - 2.9e-11 43.5 0.1 6.9e-11 42.3 0.1 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC42124.1 - 1.5e-05 24.9 0.0 4e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 PAS fold dsDNA_bind PF01984.20 EFC42124.1 - 0.078 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Double-stranded DNA-binding domain PAS_4 PF08448.10 EFC42124.1 - 0.22 11.8 0.0 0.44 10.8 0.0 1.4 1 0 0 1 1 1 0 PAS fold Phage_holin_3_1 PF05106.12 EFC42124.1 - 3 8.3 5.2 1.8 9.0 2.2 2.3 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) DUF4386 PF14329.6 EFC42125.1 - 6.6e-30 104.6 8.1 8.1e-30 104.3 8.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4386) DUF998 PF06197.13 EFC42125.1 - 0.00032 20.4 1.1 0.00054 19.6 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF998) DUF4064 PF13273.6 EFC42125.1 - 0.9 9.8 7.5 2.2 8.6 6.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) EGF_2 PF07974.13 EFC42126.1 - 1.6e-06 28.3 47.7 7.2e-06 26.3 7.0 20.2 16 5 2 18 18 18 7 EGF-like domain Xpo1 PF08389.12 EFC42126.1 - 0.81 9.7 5.7 1.6 8.8 5.7 1.4 1 0 0 1 1 1 0 Exportin 1-like protein Pro_isomerase PF00160.21 EFC42127.1 - 3.1e-40 138.0 0.1 3.5e-40 137.9 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RWP-RK PF02042.15 EFC42128.1 - 5.4e-18 64.7 0.6 1.1e-17 63.7 0.1 1.8 2 0 0 2 2 2 1 RWP-RK domain Lambda_CIII PF02061.16 EFC42128.1 - 0.077 13.1 1.3 0.23 11.6 0.5 2.0 2 0 0 2 2 2 0 Lambda Phage CIII DUF4116 PF13475.6 EFC42129.1 - 4.9e-47 157.4 13.1 4.5e-10 39.1 0.8 9.0 5 2 3 9 9 9 9 Domain of unknown function (DUF4116) eIF3_N PF09440.10 EFC42129.1 - 0.27 11.7 2.6 0.25 11.8 0.4 2.1 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain F-box PF00646.33 EFC42130.1 - 6.5e-08 32.3 0.1 3e-07 30.2 0.1 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC42130.1 - 1.3e-07 31.3 0.4 3.7e-07 29.9 0.4 1.8 1 0 0 1 1 1 1 F-box-like SIR2 PF02146.17 EFC42131.1 - 5.3e-07 29.7 1.2 1.3e-06 28.5 0.5 2.0 1 1 1 2 2 2 1 Sir2 family LRR_4 PF12799.7 EFC42133.1 - 9.6e-07 29.0 44.1 0.0064 16.9 0.8 8.9 4 3 8 12 12 12 8 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC42133.1 - 0.0015 18.3 0.5 0.0089 15.9 0.1 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC42133.1 - 0.13 12.2 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 F-box-like RCC1_2 PF13540.6 EFC42134.1 - 2.4e-22 78.2 23.0 4.7e-06 26.3 3.3 4.9 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC42134.1 - 5.8e-17 62.0 14.3 5.2e-05 23.8 0.0 5.6 4 2 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 EFC42134.1 - 0.15 12.1 3.2 5.1 7.2 0.7 3.0 2 0 0 2 2 2 0 Galactose oxidase, central domain ADH_N_2 PF16884.5 EFC42135.1 - 6.1e-19 67.9 0.1 4.1e-16 58.8 0.1 2.3 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFC42135.1 - 9.4e-14 51.5 0.0 1.5e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC42135.1 - 7.9e-09 36.7 0.0 2.5e-08 35.1 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 EFC42135.1 - 0.00065 19.2 0.2 0.0012 18.3 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase RCC1 PF00415.18 EFC42136.1 - 4.6e-35 120.0 4.1 1.8e-09 38.0 0.1 7.3 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC42136.1 - 2.3e-23 81.4 16.3 4.7e-06 26.3 1.3 6.4 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat DUF3641 PF12345.8 EFC42136.1 - 0.074 13.1 1.0 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) SPASM PF13186.6 EFC42136.1 - 0.12 12.9 2.3 4.2 8.0 0.2 3.1 3 1 0 3 3 3 0 Iron-sulfur cluster-binding domain DUF4213 PF13938.6 EFC42136.1 - 0.12 12.6 0.3 10 6.4 0.0 3.3 3 2 0 3 3 3 0 Putative heavy-metal chelation DUF4116 PF13475.6 EFC42137.1 - 3.7e-15 55.4 1.0 2.4e-08 33.6 0.0 3.3 2 1 0 2 2 2 2 Domain of unknown function (DUF4116) HisKA PF00512.25 EFC42138.1 - 0.095 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 His Kinase A (phospho-acceptor) domain GRDP-like PF07173.12 EFC42139.1 - 0.0018 18.9 1.9 0.0018 18.9 1.9 1.9 2 0 0 2 2 2 1 Glycine-rich domain-containing protein-like nsp8 PF08717.10 EFC42139.1 - 0.74 9.7 8.4 16 5.3 0.0 5.8 1 1 4 7 7 7 0 nsp8 replicase Flu_B_M2 PF04772.12 EFC42139.1 - 2.5 8.4 6.1 6.1 7.1 0.1 3.8 3 1 0 4 4 4 0 Influenza B matrix protein 2 (BM2) IQ PF00612.27 EFC42140.1 - 1.9e-05 24.0 0.8 8.6e-05 22.0 0.8 2.2 1 0 0 1 1 1 1 IQ calmodulin-binding motif Pkinase PF00069.25 EFC42141.1 - 1.2e-64 218.2 0.0 1.2e-64 218.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42141.1 - 1.9e-42 145.4 0.0 4.5e-42 144.1 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC42141.1 - 0.00079 19.4 0.0 0.71 9.7 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC42141.1 - 0.00084 18.7 1.3 0.001 18.5 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFC42141.1 - 0.0041 15.9 0.0 0.0041 15.9 0.0 3.6 2 1 0 2 2 2 1 Fungal protein kinase Ank_2 PF12796.7 EFC42142.1 - 4.2e-20 72.1 0.0 2.1e-08 34.6 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) PH PF00169.29 EFC42142.1 - 6e-20 71.7 1.2 6e-20 71.7 1.2 2.6 2 1 0 2 2 2 1 PH domain Ank_3 PF13606.6 EFC42142.1 - 2.5e-16 58.1 2.6 0.00044 20.5 0.0 6.3 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFC42142.1 - 7e-14 52.0 5.2 0.0011 19.4 0.8 5.1 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC42142.1 - 8.4e-13 48.3 0.1 0.0081 16.5 0.0 4.8 2 1 3 5 5 5 3 Ankyrin repeats (many copies) WW PF00397.26 EFC42142.1 - 2.3e-11 43.5 2.6 7.8e-11 41.9 2.6 1.9 1 0 0 1 1 1 1 WW domain Ank PF00023.30 EFC42142.1 - 1.6e-10 40.9 1.5 0.0024 18.3 0.1 5.4 6 0 0 6 6 6 2 Ankyrin repeat PH_11 PF15413.6 EFC42142.1 - 0.0031 17.9 12.7 0.019 15.4 6.5 3.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 EFC42142.1 - 0.025 15.0 0.2 0.025 15.0 0.2 2.4 2 1 1 3 3 3 0 Pleckstrin homology domain Mcp5_PH PF12814.7 EFC42142.1 - 0.095 12.8 1.6 0.18 11.9 0.6 2.0 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology DUF2222 PF09984.9 EFC42142.1 - 0.16 11.8 3.6 0.1 12.5 1.4 1.9 2 0 0 2 2 2 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) DUF4661 PF15576.6 EFC42142.1 - 0.82 9.5 5.5 11 5.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4661) AMP-binding PF00501.28 EFC42144.1 - 6.4e-76 255.6 0.0 8.2e-76 255.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC42144.1 - 8.6e-21 74.7 0.8 1.9e-20 73.6 0.8 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EFC42144.1 - 5.8e-20 71.0 1.4 1.2e-19 70.0 1.4 1.5 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Myb_DNA-binding PF00249.31 EFC42145.1 - 2.2e-11 43.8 0.1 4.6e-11 42.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC42145.1 - 0.0043 17.3 0.3 0.021 15.1 0.3 2.3 1 1 0 1 1 1 1 Myb-like DNA-binding domain Mito_carr PF00153.27 EFC42146.1 - 1.7e-74 245.8 5.3 2.8e-25 88.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein RRM_1 PF00076.22 EFC42148.1 - 4.3e-18 64.9 0.2 6.3e-18 64.4 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC42148.1 - 0.00077 19.3 0.0 0.0026 17.6 0.0 1.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif Nup35_RRM PF05172.13 EFC42148.1 - 0.0082 16.1 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 EFC42148.1 - 0.0088 15.9 0.0 0.014 15.2 0.0 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF1866) Nup35_RRM_2 PF14605.6 EFC42148.1 - 0.014 15.4 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_Rrp7 PF17799.1 EFC42148.1 - 0.02 14.7 0.0 0.28 10.9 0.0 1.9 1 1 0 1 1 1 0 Rrp7 RRM-like N-terminal domain Nsp1_C PF05064.13 EFC42148.1 - 0.073 12.9 0.9 0.12 12.1 0.9 1.3 1 0 0 1 1 1 0 Nsp1-like C-terminal region RRM_7 PF16367.5 EFC42148.1 - 0.18 11.9 0.0 0.55 10.4 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif ECH_1 PF00378.20 EFC42149.1 - 2e-45 155.1 0.1 8e-45 153.1 0.1 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC42149.1 - 9.7e-30 104.2 0.1 1.5e-26 93.7 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase CC PF04942.14 EFC42149.1 - 0.055 13.7 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 CC domain Golgin_A5 PF09787.9 EFC42150.1 - 1.2e-46 159.7 30.0 1.2e-46 159.7 30.0 3.5 1 1 2 3 3 3 2 Golgin subfamily A member 5 HOOK PF05622.12 EFC42150.1 - 0.0011 17.2 32.0 0.0011 17.2 32.0 3.4 1 1 2 3 3 3 1 HOOK protein ADIP PF11559.8 EFC42150.1 - 0.015 15.4 14.7 0.015 15.4 14.7 5.7 2 2 3 5 5 5 0 Afadin- and alpha -actinin-Binding GP44 PF17510.2 EFC42150.1 - 2 8.7 11.2 0.12 12.6 0.6 3.7 3 2 1 5 5 5 0 Gene product 44 PARP_regulatory PF01358.18 EFC42151.1 - 7.1e-33 113.8 0.8 9e-33 113.4 0.8 1.0 1 0 0 1 1 1 1 Poly A polymerase regulatory subunit LAGLIDADG_1 PF00961.19 EFC42153.1 - 4.5 8.3 10.3 3.3 8.7 0.7 3.5 3 1 0 3 3 3 0 LAGLIDADG endonuclease RGS PF00615.19 EFC42154.1 - 1.5e-08 34.9 0.0 3.1e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Tmemb_14 PF03647.13 EFC42154.1 - 0.64 10.8 7.0 0.2 12.4 0.7 3.0 2 1 1 3 3 3 0 Transmembrane proteins 14C AAA_2 PF07724.14 EFC42155.1 - 1.2e-39 136.2 0.0 5.7e-39 134.0 0.1 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ClpB_D2-small PF10431.9 EFC42155.1 - 3.6e-17 62.2 0.1 3.6e-17 62.2 0.1 2.7 3 0 0 3 3 2 1 C-terminal, D2-small domain, of ClpB protein AAA_lid_9 PF17871.1 EFC42155.1 - 6.3e-16 58.2 0.7 6.3e-16 58.2 0.7 2.4 2 0 0 2 2 2 1 AAA lid domain AAA_5 PF07728.14 EFC42155.1 - 1.9e-13 50.6 0.2 2.1e-10 40.8 0.0 3.6 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) AAA PF00004.29 EFC42155.1 - 8e-09 36.0 0.3 3.7e-05 24.2 0.0 3.9 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC42155.1 - 2.6e-07 30.5 0.1 3.9e-06 26.7 0.1 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain DNA_pol3_delta2 PF13177.6 EFC42155.1 - 0.00043 20.1 0.0 0.02 14.7 0.0 2.9 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_24 PF13479.6 EFC42155.1 - 0.0012 18.6 0.3 0.0041 16.9 0.1 2.1 2 0 0 2 2 1 1 AAA domain AAA_7 PF12775.7 EFC42155.1 - 0.0017 17.9 0.1 0.33 10.4 0.1 3.3 3 0 0 3 3 3 1 P-loop containing dynein motor region Torsin PF06309.11 EFC42155.1 - 0.0021 18.1 0.1 0.0054 16.8 0.1 1.7 1 0 0 1 1 1 1 Torsin RsgA_GTPase PF03193.16 EFC42155.1 - 0.011 15.6 0.2 0.77 9.7 0.1 2.7 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 EFC42155.1 - 0.015 15.7 0.0 0.91 9.9 0.0 3.1 3 1 1 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 EFC42155.1 - 0.016 15.5 1.0 0.13 12.5 0.1 3.0 2 1 0 2 2 1 0 AAA domain RuvB_N PF05496.12 EFC42155.1 - 0.02 14.6 0.0 0.16 11.7 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 EFC42155.1 - 0.042 13.7 0.0 0.13 12.1 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFC42155.1 - 0.042 14.3 0.6 3.7 8.1 0.0 3.7 3 1 0 3 3 3 0 ABC transporter ABC_tran_CTD PF16326.5 EFC42155.1 - 0.048 13.9 2.5 0.87 9.9 0.0 3.2 3 0 0 3 3 2 0 ABC transporter C-terminal domain AAA_33 PF13671.6 EFC42155.1 - 0.07 13.3 0.0 0.32 11.2 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC42155.1 - 0.072 13.6 0.3 0.34 11.4 0.0 2.4 2 0 0 2 2 1 0 AAA domain CbiA PF01656.23 EFC42155.1 - 0.13 12.3 0.4 1.1 9.3 0.0 2.7 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 EFC42155.1 - 0.13 12.0 0.0 0.44 10.3 0.0 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein MbeD_MobD PF04899.12 EFC42155.1 - 0.17 12.0 1.9 0.73 10.0 0.4 2.5 2 0 0 2 2 2 0 MbeD/MobD like DUF4268 PF14088.6 EFC42155.1 - 0.47 10.3 4.1 9 6.2 0.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4268) Seryl_tRNA_N PF02403.22 EFC42155.1 - 3.1 8.1 20.7 3.2 8.0 1.8 5.0 4 1 1 5 5 5 0 Seryl-tRNA synthetase N-terminal domain CHZ PF09649.10 EFC42156.1 - 2e-06 27.2 0.1 6e-05 22.4 0.1 2.2 2 0 0 2 2 2 2 Histone chaperone domain CHZ LRR_6 PF13516.6 EFC42157.1 - 5.9e-49 160.0 50.4 2.3e-05 24.1 0.0 18.8 20 0 0 20 20 20 13 Leucine Rich repeat LRR_8 PF13855.6 EFC42157.1 - 2.2e-32 110.6 45.1 2e-07 30.6 2.7 9.7 5 1 6 12 12 12 8 Leucine rich repeat LRR_4 PF12799.7 EFC42157.1 - 7.6e-30 102.5 53.5 3.6e-08 33.6 0.7 12.4 6 2 5 12 12 12 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC42157.1 - 6e-11 42.2 16.2 3.7e-05 23.3 0.5 5.0 1 1 5 6 6 6 3 Leucine-rich repeat LRR_1 PF00560.33 EFC42157.1 - 1.9e-09 36.7 24.5 15 6.7 0.0 13.6 14 1 1 15 15 15 3 Leucine Rich Repeat SCF PF02404.15 EFC42158.1 - 0.011 15.1 0.1 0.014 14.7 0.1 1.2 1 0 0 1 1 1 0 Stem cell factor NHL PF01436.21 EFC42159.1 - 2.6e-05 24.0 0.2 0.0074 16.3 0.0 2.8 3 0 0 3 3 3 2 NHL repeat DUF4116 PF13475.6 EFC42160.1 - 1.8e-52 174.8 25.9 3e-11 42.8 0.3 9.3 6 2 3 9 9 9 8 Domain of unknown function (DUF4116) DUF778 PF05608.12 EFC42160.1 - 0.093 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF778) Ras PF00071.22 EFC42161.1 - 9.7e-12 44.8 0.0 1.6e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC42161.1 - 1.1e-05 25.6 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Paz_1 PF18349.1 EFC42161.1 - 0.018 15.0 0.4 1.1 9.3 0.1 2.9 3 0 0 3 3 3 0 PAZ domain CCT_2 PF09425.10 EFC42162.1 - 0.59 10.1 4.4 11 6.0 0.3 2.4 2 0 0 2 2 2 0 Divergent CCT motif API5 PF05918.11 EFC42162.1 - 4.7 5.9 12.1 5.6 5.7 12.1 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) JAB PF01398.21 EFC42163.1 - 2.5e-14 53.3 2.0 3.7e-14 52.7 0.1 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Peptidase_S41 PF03572.18 EFC42163.1 - 0.072 12.7 1.5 0.16 11.5 0.1 2.2 3 0 0 3 3 3 0 Peptidase family S41 HMG_box PF00505.19 EFC42164.1 - 1.4e-12 47.9 16.9 1.3e-09 38.3 0.8 2.9 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC42164.1 - 0.011 16.3 11.0 0.36 11.5 2.5 3.6 2 2 1 3 3 3 0 HMG-box domain DUF3810 PF12725.7 EFC42164.1 - 0.63 9.3 6.2 0.073 12.4 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) TPR_19 PF14559.6 EFC42165.1 - 0.01 16.3 0.1 0.11 13.1 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42165.1 - 0.093 12.9 3.9 20 5.6 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42165.1 - 0.82 9.6 4.1 14 5.7 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat AIM3 PF17096.5 EFC42165.1 - 4.2 8.4 6.7 2.8 8.9 2.6 2.3 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Iso_dh PF00180.20 EFC42166.1 - 4.8e-64 216.7 0.0 1.7e-60 205.1 0.1 2.1 2 0 0 2 2 2 2 Isocitrate/isopropylmalate dehydrogenase CN_hydrolase PF00795.22 EFC42167.1 - 1e-51 175.8 0.0 1.3e-51 175.5 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RNA_ligase PF09414.10 EFC42168.1 - 1.4e-25 90.4 0.0 2e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 RNA ligase LPD28 PF18843.1 EFC42168.1 - 0.048 13.3 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 28 LRRFIP PF09738.9 EFC42169.1 - 0.00056 19.5 12.2 0.00083 18.9 12.2 1.3 1 1 0 1 1 1 1 LRRFIP family XRCC4 PF06632.12 EFC42169.1 - 0.0012 17.8 19.0 0.017 14.0 18.9 2.4 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3287 PF11690.8 EFC42169.1 - 0.023 14.4 0.9 0.027 14.2 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) DUF724 PF05266.14 EFC42169.1 - 0.026 14.3 8.9 0.031 14.1 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF1764 PF08576.10 EFC42169.1 - 0.42 11.5 10.9 0.6 11.1 10.9 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF4446 PF14584.6 EFC42169.1 - 0.47 10.4 10.7 0.26 11.3 8.9 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4407 PF14362.6 EFC42169.1 - 0.67 9.3 4.1 0.74 9.1 4.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2681 PF10883.8 EFC42169.1 - 0.71 10.3 18.0 21 5.6 14.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) DUF3573 PF12097.8 EFC42169.1 - 0.92 8.3 8.8 1.1 8.1 8.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) YabA PF06156.13 EFC42169.1 - 0.96 10.1 13.6 1.9 9.1 13.6 1.7 1 1 0 1 1 1 0 Initiation control protein YabA ALMT PF11744.8 EFC42169.1 - 1.2 7.8 10.5 1.3 7.7 10.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CENP-H PF05837.12 EFC42169.1 - 1.3 9.4 12.7 3.1 8.3 12.9 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) DivIC PF04977.15 EFC42169.1 - 2.8 7.8 11.6 7.6 6.4 11.3 1.9 1 1 0 1 1 1 0 Septum formation initiator TMPIT PF07851.13 EFC42169.1 - 5.8 6.1 9.4 6.3 5.9 9.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein WD40 PF00400.32 EFC42170.1 - 1.3e-21 76.4 12.0 2.1e-08 34.7 0.2 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42170.1 - 1.4e-07 31.7 4.3 0.044 14.1 0.2 3.7 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 EFC42170.1 - 0.088 12.8 0.2 0.24 11.4 0.2 1.8 1 0 0 1 1 1 0 LisH zf-C3HC4_3 PF13920.6 EFC42171.1 - 8.3e-05 22.4 19.4 0.00015 21.6 12.5 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC42171.1 - 0.21 11.5 18.8 3.7 7.5 12.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 CCDC-167 PF15188.6 EFC42171.1 - 8.8 6.8 11.7 22 5.4 0.3 2.6 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 USP7_C2 PF14533.6 EFC42172.1 - 0.044 13.5 2.6 0.3 10.8 0.1 2.4 2 1 0 2 2 2 0 Ubiquitin-specific protease C-terminal PB1 PF00564.24 EFC42172.1 - 0.13 12.3 1.9 0.79 9.7 0.1 2.7 3 0 0 3 3 3 0 PB1 domain Linker_histone PF00538.19 EFC42173.1 - 0.08 13.3 1.6 0.14 12.5 0.5 2.1 2 0 0 2 2 2 0 linker histone H1 and H5 family Merozoite_SPAM PF07133.11 EFC42173.1 - 0.11 12.5 13.0 0.13 12.2 13.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) PAP2 PF01569.21 EFC42174.1 - 2.7e-11 43.4 0.0 5.1e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 PAP2 superfamily VCPO_N PF17897.1 EFC42174.1 - 0.00021 21.1 0.0 0.00062 19.6 0.0 1.7 2 0 0 2 2 2 1 Vanadium chloroperoxidase N-terminal domain Peptidase_C1 PF00112.23 EFC42175.1 - 5.7e-71 239.1 5.0 7.6e-71 238.7 5.0 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFC42175.1 - 1.5e-08 34.9 2.2 3.2e-08 33.9 2.2 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFC42175.1 - 2e-05 23.6 1.1 0.011 14.6 0.0 2.8 2 1 1 3 3 3 2 Peptidase C1-like family ANAPC4_WD40 PF12894.7 EFC42176.1 - 2.3e-11 43.8 2.9 0.014 15.7 0.0 4.9 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC42176.1 - 0.00038 21.2 1.5 9.7 7.2 0.0 5.8 7 0 0 7 7 7 1 WD domain, G-beta repeat B_lectin PF01453.24 EFC42176.1 - 0.0043 17.6 3.9 1.3 9.6 0.1 2.8 3 0 0 3 3 3 2 D-mannose binding lectin NHL PF01436.21 EFC42176.1 - 0.0084 16.1 0.2 0.3 11.2 0.0 3.2 3 0 0 3 3 3 1 NHL repeat Sel1 PF08238.12 EFC42178.1 - 7e-36 121.9 12.7 1.7e-07 31.7 0.6 5.3 4 1 1 5 5 5 5 Sel1 repeat TPR_17 PF13431.6 EFC42178.1 - 0.0033 17.7 0.9 2.6 8.6 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat NRN1 PF15056.6 EFC42178.1 - 0.031 14.4 0.2 0.031 14.4 0.2 2.8 3 0 0 3 3 3 0 Neuritin protein family Flu_NS2 PF00601.19 EFC42178.1 - 0.089 13.1 5.5 0.094 13.0 1.2 2.7 2 0 0 2 2 2 0 Influenza non-structural protein (NS2) HgmA PF04209.13 EFC42178.1 - 0.14 10.8 0.8 1.5 7.5 0.0 2.1 2 0 0 2 2 2 0 homogentisate 1,2-dioxygenase HetR_C PF18460.1 EFC42178.1 - 0.38 10.7 2.5 7 6.6 0.4 2.7 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain TPR_8 PF13181.6 EFC42178.1 - 2.8 8.4 6.5 26 5.4 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat SBP_bac_3 PF00497.20 EFC42179.1 - 4.1e-12 46.0 0.0 6e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Pyr_redox_2 PF07992.14 EFC42180.1 - 1.5e-53 182.0 0.3 1.9e-53 181.6 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFC42180.1 - 4.3e-28 97.8 0.0 8.2e-28 96.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFC42180.1 - 6.3e-16 58.7 1.6 1.8e-11 44.4 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC42180.1 - 1.7e-09 37.4 1.1 1.3e-06 27.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC42180.1 - 1.5e-05 24.3 0.9 0.00066 18.9 0.7 2.4 2 0 0 2 2 2 1 FAD binding domain K_oxygenase PF13434.6 EFC42180.1 - 3.6e-05 23.1 0.1 0.3 10.2 0.0 2.9 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 EFC42180.1 - 0.0019 17.5 0.1 0.024 13.9 0.1 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EFC42180.1 - 0.0073 15.1 0.6 0.021 13.5 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 EFC42180.1 - 0.0079 15.8 0.4 0.25 10.9 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EFC42180.1 - 0.052 12.6 2.3 0.072 12.2 1.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 EFC42180.1 - 0.061 12.7 1.6 0.063 12.6 0.6 1.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 EFC42180.1 - 0.07 12.4 0.1 0.15 11.3 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 EFC42180.1 - 0.12 11.4 0.2 0.18 10.8 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_8 PF13450.6 EFC42180.1 - 0.16 12.2 0.3 0.39 11.0 0.3 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain RCC1 PF00415.18 EFC42181.1 - 1.2e-28 99.4 2.2 2.6e-05 24.7 0.0 9.1 8 2 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC42181.1 - 3.7e-19 68.0 15.0 1.2e-05 25.0 0.0 8.0 8 1 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat ParBc_2 PF08857.11 EFC42181.1 - 0.03 14.4 1.0 0.11 12.6 1.0 1.9 1 1 0 1 1 1 0 Putative ParB-like nuclease WD40 PF00400.32 EFC42182.1 - 4.9e-10 39.8 11.4 0.066 14.1 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42182.1 - 0.0017 18.6 0.0 8.3 6.8 0.0 3.6 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Beach PF02138.18 EFC42183.1 - 9.9e-116 385.9 0.2 1.8e-115 385.0 0.2 1.5 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 EFC42183.1 - 1.1e-20 73.6 21.7 0.0016 19.2 0.9 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat PH_BEACH PF14844.6 EFC42183.1 - 3e-11 43.3 0.8 1.7e-09 37.7 0.6 3.3 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH ANAPC4_WD40 PF12894.7 EFC42183.1 - 3.5e-09 36.9 0.2 0.00039 20.7 0.1 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC42183.1 - 7e-08 32.1 9.7 1.8e-06 27.5 0.1 3.8 4 1 0 4 4 4 2 WD40-like domain GRAM PF02893.20 EFC42183.1 - 0.00011 22.0 2.1 0.0029 17.5 0.1 2.6 2 0 0 2 2 2 1 GRAM domain Frtz PF11768.8 EFC42183.1 - 0.065 11.5 3.3 0.035 12.4 0.4 1.9 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz LRR_6 PF13516.6 EFC42184.1 - 4.6e-49 160.3 34.5 0.00066 19.5 0.1 18.3 20 0 0 20 20 20 12 Leucine Rich repeat LRR_8 PF13855.6 EFC42184.1 - 1e-39 134.1 31.4 4.4e-09 36.0 5.4 8.9 4 1 6 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 EFC42184.1 - 3.4e-28 97.2 47.5 0.00031 21.1 2.0 12.6 4 2 9 14 14 14 13 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC42184.1 - 3e-12 46.4 16.6 0.0013 18.2 0.3 5.7 1 1 2 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EFC42184.1 - 1.8e-09 36.8 24.7 3 8.7 0.1 13.6 14 2 0 14 14 14 2 Leucine Rich Repeat F-box-like PF12937.7 EFC42184.1 - 0.001 18.9 0.0 0.0022 17.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like PTCB-BRCT PF12738.7 EFC42184.1 - 0.0091 15.9 0.3 1.3 9.1 0.0 4.6 5 1 1 6 6 6 1 twin BRCT domain F-box PF00646.33 EFC42184.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.7 1 0 0 1 1 1 0 F-box domain NKWYS PF10364.9 EFC42184.1 - 0.51 10.5 17.1 0.65 10.1 0.6 5.1 4 1 3 7 7 7 0 Putative capsular polysaccharide synthesis protein Pkinase PF00069.25 EFC42185.1 - 1e-31 110.3 0.5 1e-31 110.3 0.5 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42185.1 - 6e-18 65.0 0.1 1.2e-17 64.0 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_3 PF13606.6 EFC42185.1 - 2.1e-05 24.5 0.3 0.00023 21.4 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EFC42185.1 - 4.2e-05 24.1 0.0 0.00026 21.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC42185.1 - 0.00099 19.4 0.0 0.0028 17.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 EFC42185.1 - 0.0028 18.0 0.5 0.012 16.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 EFC42185.1 - 0.04 14.5 0.0 0.13 12.8 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Kdo PF06293.14 EFC42185.1 - 0.19 11.1 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acetyltransf_1 PF00583.25 EFC42186.1 - 6.2e-12 45.8 0.0 3.4e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family ZZ PF00569.17 EFC42186.1 - 8.4e-10 38.3 9.9 8.4e-10 38.3 9.9 4.0 4 1 0 4 4 4 1 Zinc finger, ZZ type Acetyltransf_7 PF13508.7 EFC42186.1 - 1.4e-09 38.2 0.0 5.6e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC42186.1 - 4e-06 26.8 0.0 0.0012 18.8 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC42186.1 - 0.0011 19.7 0.0 0.062 14.0 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC42186.1 - 0.0022 17.5 0.8 0.0041 16.6 0.8 1.4 1 0 0 1 1 1 1 Putative acetyl-transferase C1_2 PF03107.16 EFC42186.1 - 0.0026 18.0 7.0 0.0026 18.0 7.0 3.5 3 0 0 3 3 3 1 C1 domain Acetyltransf_CG PF14542.6 EFC42186.1 - 0.0071 16.4 0.0 0.018 15.2 0.0 1.6 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFC42186.1 - 0.018 15.0 0.0 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 FR47-like protein Guanylate_cyc PF00211.20 EFC42187.1 - 1.5e-40 138.8 0.3 7.4e-40 136.5 0.0 2.3 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC42187.1 - 3.2e-12 46.6 0.1 1.7e-11 44.2 0.1 2.4 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC42187.1 - 8.9e-07 28.9 0.0 3e-06 27.2 0.0 1.9 1 0 0 1 1 1 1 PAS fold DUF4469 PF14734.6 EFC42187.1 - 0.039 14.1 2.5 0.11 12.7 2.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4469) with IG-like fold PAS_8 PF13188.7 EFC42187.1 - 0.045 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 PAS domain DUF2073 PF09846.9 EFC42187.1 - 0.047 13.6 0.6 3.6 7.5 0.0 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2073) HNOBA PF07701.14 EFC42187.1 - 0.049 13.0 0.5 0.13 11.7 0.5 1.7 1 0 0 1 1 1 0 Heme NO binding associated PAS_4 PF08448.10 EFC42187.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold DUF1147 PF06615.11 EFC42188.1 - 0.036 14.1 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) Guanylate_cyc PF00211.20 EFC42190.1 - 3.1e-29 101.9 0.1 6.9e-29 100.8 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC42190.1 - 4.7e-09 36.4 1.5 4.7e-09 36.4 1.5 1.7 2 0 0 2 2 2 1 Cache domain DUF4577 PF15145.6 EFC42190.1 - 0.083 12.9 8.3 1.7 8.7 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Fic PF02661.18 EFC42191.1 - 8.6e-10 39.4 0.0 7e-09 36.5 0.0 2.4 2 0 0 2 2 2 1 Fic/DOC family Alpha-2-MRAP_C PF06401.11 EFC42191.1 - 0.021 14.8 2.9 4.1 7.3 0.3 2.5 2 1 0 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain CCDC-167 PF15188.6 EFC42191.1 - 2 8.8 6.1 0.58 10.5 0.2 2.6 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 F-box-like PF12937.7 EFC42192.1 - 0.025 14.5 0.5 0.066 13.1 0.5 1.7 1 0 0 1 1 1 0 F-box-like MerR_2 PF13591.6 EFC42192.1 - 0.099 12.5 0.0 3.2 7.7 0.0 2.6 2 0 0 2 2 2 0 MerR HTH family regulatory protein DUF4404 PF14357.6 EFC42193.1 - 0.99 10.1 0.1 0.99 10.1 0.1 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) Mfp-3 PF04202.13 EFC42194.1 - 0.0022 18.3 5.7 0.0022 18.3 5.7 3.2 1 1 1 2 2 2 1 Foot protein 3 LPAM_1 PF08139.12 EFC42194.1 - 0.16 12.5 0.7 0.23 12.0 0.7 1.2 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DUF4116 PF13475.6 EFC42195.1 - 6.6e-95 310.7 54.9 7.8e-13 47.9 0.0 17.2 9 3 7 17 17 17 16 Domain of unknown function (DUF4116) DUF4042 PF13251.6 EFC42195.1 - 0.069 12.8 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) VPS9 PF02204.18 EFC42196.1 - 2.1e-20 72.9 0.3 7.6e-20 71.1 0.3 2.1 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF547 PF04784.14 EFC42196.1 - 9.3e-15 54.7 0.0 2.7e-14 53.3 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function, DUF547 PH PF00169.29 EFC42196.1 - 7.6e-09 36.0 1.4 4.5e-08 33.5 1.4 2.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFC42196.1 - 0.0012 19.3 1.9 0.0092 16.4 1.9 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_15 PF17339.2 EFC42196.1 - 0.044 13.7 0.1 0.16 11.9 0.1 1.9 1 0 0 1 1 1 0 PH domain Abhydrolase_2 PF02230.16 EFC42197.1 - 2.9e-49 167.8 0.2 4.2e-49 167.3 0.2 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFC42197.1 - 9.1e-06 25.1 0.0 0.076 12.3 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC42197.1 - 0.0027 17.2 0.3 0.75 9.2 0.0 3.4 4 0 0 4 4 4 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFC42197.1 - 0.0031 18.1 0.0 0.0045 17.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 EFC42197.1 - 0.0071 16.2 1.3 0.079 12.8 0.0 2.5 2 1 0 2 2 2 1 Palmitoyl protein thioesterase Abhydrolase_3 PF07859.13 EFC42197.1 - 0.0084 16.0 0.0 0.014 15.2 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2974 PF11187.8 EFC42197.1 - 0.011 15.3 0.4 0.19 11.2 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2974) Sen15 PF09631.10 EFC42197.1 - 0.042 14.2 0.0 1.1 9.6 0.0 2.7 1 1 0 2 2 2 0 Sen15 protein Abhydrolase_1 PF00561.20 EFC42197.1 - 0.083 12.5 0.1 0.19 11.3 0.1 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Phosphodiest PF01663.22 EFC42198.1 - 3.2e-86 290.1 0.0 3.9e-86 289.9 0.0 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFC42198.1 - 0.00014 21.4 0.0 0.0021 17.5 0.0 2.3 2 0 0 2 2 2 1 Sulfatase Ank_5 PF13857.6 EFC42199.1 - 0.022 15.1 0.0 0.098 13.0 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Mlp PF03304.13 EFC42199.1 - 1.4 9.2 9.7 0.044 14.0 2.9 2.0 2 0 0 2 2 2 0 Mlp lipoprotein family 2_5_RNA_ligase2 PF13563.6 EFC42200.1 - 5.1e-38 130.4 0.0 6.3e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EFC42200.1 - 1.5e-05 25.1 0.1 0.22 11.7 0.0 2.5 2 0 0 2 2 2 2 LigT like Phosphoesterase Coilin_N PF15862.5 EFC42200.1 - 0.67 9.7 5.3 5.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Coilin N-terminus Kinesin_assoc PF16183.5 EFC42200.1 - 0.8 9.8 4.5 1.5 8.9 1.1 2.7 1 1 1 2 2 2 0 Kinesin-associated Lactamase_B_2 PF12706.7 EFC42201.1 - 1.9e-06 27.5 0.1 4.1e-05 23.2 0.1 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain GnsAB_toxin PF08178.11 EFC42201.1 - 0.0055 16.6 1.3 0.011 15.6 1.3 1.5 1 0 0 1 1 1 1 GnsA/GnsB toxin of bacterial toxin-antitoxin system ASC PF00858.24 EFC42202.1 - 1e-14 54.4 15.9 8.3e-05 21.7 0.4 3.1 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel ASC PF00858.24 EFC42203.1 - 1.7e-09 37.2 11.1 0.0001 21.4 0.5 3.0 2 1 1 3 3 3 3 Amiloride-sensitive sodium channel Endonuclease_5 PF04493.14 EFC42204.1 - 4.5e-66 222.3 0.0 5.1e-66 222.1 0.0 1.0 1 0 0 1 1 1 1 Endonuclease V UvrC_HhH_N PF08459.11 EFC42204.1 - 0.0051 16.7 0.0 0.0075 16.2 0.0 1.3 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal DUF99 PF01949.16 EFC42204.1 - 0.066 12.6 0.1 0.25 10.7 0.1 2.2 2 1 0 2 2 2 0 Protein of unknown function DUF99 RGS PF00615.19 EFC42206.1 - 2.6e-05 24.5 0.5 3.9e-05 23.9 0.5 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain EAP30 PF04157.16 EFC42206.1 - 0.064 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 EAP30/Vps36 family Glyco_hydro_57 PF03065.15 EFC42206.1 - 0.11 11.7 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 HMG_box PF00505.19 EFC42207.1 - 5.5e-13 49.1 23.7 1.8e-07 31.4 2.2 2.9 3 1 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC42207.1 - 7.1e-11 42.6 18.5 2.4e-07 31.2 2.2 2.7 3 0 0 3 3 3 2 HMG-box domain Oxidored_nitro PF00148.19 EFC42207.1 - 0.026 13.3 2.1 0.22 10.2 2.1 2.0 1 1 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase YqzH PF14164.6 EFC42207.1 - 0.19 11.8 5.4 1.4 9.0 0.7 2.9 2 0 0 2 2 2 0 YqzH-like protein Urocanase PF01175.18 EFC42207.1 - 1.2 8.8 4.7 0.24 11.0 0.6 1.8 2 1 0 2 2 2 0 Urocanase Rossmann-like domain BRCA-2_OB3 PF09104.10 EFC42207.1 - 4.5 6.9 7.8 0.66 9.6 0.7 2.5 2 1 1 3 3 3 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 CompInhib_SCIN PF11546.8 EFC42208.1 - 0.0062 16.6 0.3 0.17 11.9 0.1 2.6 2 0 0 2 2 2 1 Staphylococcal complement inhibitor SCIN LRAT PF04970.13 EFC42208.1 - 0.78 10.1 5.4 2.1 8.7 0.1 3.6 4 1 0 4 4 4 0 Lecithin retinol acyltransferase DUF1456 PF07308.13 EFC42209.1 - 0.1 12.9 0.3 0.42 11.0 0.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) FAD-oxidase_C PF02913.19 EFC42211.1 - 1.3e-28 100.3 0.0 1.8e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFC42211.1 - 1.5e-12 47.4 0.0 2.6e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFC42211.1 - 0.1 12.7 0.1 0.45 10.7 0.0 2.1 2 0 0 2 2 2 0 Berberine and berberine like Cystatin PF00031.21 EFC42212.1 - 0.052 13.8 0.1 0.096 13.0 0.1 1.8 1 1 0 1 1 1 0 Cystatin domain C-C_Bond_Lyase PF15617.6 EFC42212.1 - 0.073 12.2 0.0 0.081 12.1 0.0 1.2 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold ADH_zinc_N PF00107.26 EFC42213.1 - 3.6e-25 88.4 0.2 6.6e-25 87.6 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC42213.1 - 2.1e-23 82.3 1.4 4.2e-23 81.3 1.4 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain UDPG_MGDP_dh_N PF03721.14 EFC42213.1 - 0.00041 20.0 0.2 0.00063 19.4 0.2 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N_2 PF13602.6 EFC42213.1 - 0.045 14.8 0.0 0.096 13.7 0.0 1.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 EFC42213.1 - 0.096 12.0 0.4 0.14 11.4 0.4 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 EFC42214.1 - 6e-19 68.4 0.2 9.1e-19 67.8 0.2 1.2 1 0 0 1 1 1 1 ThiF family GLE1 PF07817.13 EFC42215.1 - 3.5e-29 101.8 0.3 4.4e-29 101.4 0.3 1.0 1 0 0 1 1 1 1 GLE1-like protein Sod_Fe_C PF02777.18 EFC42216.1 - 2e-31 108.2 0.8 3.8e-31 107.3 0.8 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFC42216.1 - 8.8e-22 77.4 2.3 3e-21 75.7 0.3 2.4 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DUF3900 PF13039.6 EFC42216.1 - 0.0087 16.0 0.2 0.051 13.5 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3900) Sgf11 PF08209.11 EFC42217.1 - 4.9e-14 51.6 3.3 7.2e-14 51.1 3.3 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) SPT6_acidic PF14632.6 EFC42217.1 - 9.4 6.9 47.1 0.24 12.0 18.9 3.5 2 1 1 3 3 3 0 Acidic N-terminal SPT6 Ras PF00071.22 EFC42218.1 - 1.4e-15 57.3 0.3 3.4e-10 39.8 0.0 2.3 2 0 0 2 2 2 2 Ras family Arf PF00025.21 EFC42218.1 - 0.017 14.6 0.0 0.83 9.1 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family Takusan PF04822.13 EFC42218.1 - 3.4 7.6 10.4 3.1 7.7 0.1 3.6 3 1 1 4 4 4 0 Takusan LRR_4 PF12799.7 EFC42219.1 - 2.2e-13 50.2 32.7 0.003 17.9 3.1 8.1 5 3 3 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC42219.1 - 1e-06 28.4 23.7 0.0041 16.9 0.1 5.7 5 2 2 7 7 7 5 Leucine rich repeat LRR_6 PF13516.6 EFC42219.1 - 2.2e-06 27.3 26.9 0.26 11.4 1.2 7.9 8 1 1 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 EFC42219.1 - 0.25 12.1 24.7 26 5.9 0.2 8.4 8 1 0 8 8 8 0 Leucine Rich Repeat Beta_helix PF13229.6 EFC42221.1 - 6e-05 22.9 26.7 0.00083 19.2 26.6 2.7 2 1 1 3 3 3 2 Right handed beta helix region DUF1565 PF07602.11 EFC42221.1 - 0.0012 18.2 0.0 0.0012 18.2 0.0 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF1565) PhoLip_ATPase_C PF16212.5 EFC42222.1 - 2.5e-66 224.0 24.9 2.5e-66 224.0 24.9 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC42222.1 - 5.6e-24 83.6 3.7 5.6e-24 83.6 3.7 2.1 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFC42222.1 - 1.6e-16 60.2 0.1 3.9e-14 52.5 0.0 2.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC42222.1 - 4.1e-14 53.4 1.7 0.0004 20.7 0.1 3.6 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFC42222.1 - 4.1e-13 49.3 0.8 4.1e-13 49.3 0.8 2.8 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFC42222.1 - 0.0035 17.1 1.7 0.0035 17.1 1.7 3.8 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Mito_carr PF00153.27 EFC42223.1 - 2.6e-52 174.7 5.5 1.4e-20 73.0 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein LysM PF01476.20 EFC42224.1 - 0.0017 18.4 0.0 0.0038 17.2 0.0 1.6 1 0 0 1 1 1 1 LysM domain TAP_C PF03943.13 EFC42224.1 - 0.025 14.2 0.5 0.025 14.2 0.5 2.0 2 0 0 2 2 2 0 TAP C-terminal domain E7 PF00527.18 EFC42224.1 - 0.19 12.0 2.9 0.11 12.7 0.7 1.7 2 0 0 2 2 2 0 E7 protein, Early protein PB1 PF00564.24 EFC42225.1 - 0.0016 18.4 1.9 0.0017 18.2 0.4 1.9 2 0 0 2 2 2 1 PB1 domain BUD22 PF09073.10 EFC42225.1 - 2.1 7.6 21.7 4.3 6.6 21.7 1.4 1 1 0 1 1 1 0 BUD22 LELP1 PF15042.6 EFC42225.1 - 9.2 6.7 11.2 3.6 8.0 2.4 2.4 2 0 0 2 2 2 0 Late cornified envelope-like proline-rich protein 1 A_thal_3526 PF09713.10 EFC42226.1 - 2.9e-21 75.4 5.0 2.9e-21 75.4 5.0 2.9 3 0 0 3 3 3 1 Plant protein 1589 of unknown function (A_thal_3526) Prominin PF05478.11 EFC42228.1 - 4.1e-12 44.9 17.8 1.5e-07 29.9 11.2 3.4 2 1 0 2 2 2 2 Prominin MICSWaP PF17018.5 EFC42228.1 - 0.18 11.3 2.8 0.98 8.9 0.2 2.7 2 1 1 3 3 3 0 Spore wall protein Acetyltransf_1 PF00583.25 EFC42229.1 - 1.8e-13 50.8 0.0 2.2e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC42229.1 - 4.6e-11 43.0 0.2 8.1e-11 42.2 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC42229.1 - 2.5e-08 33.9 0.0 3.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC42229.1 - 0.00016 21.5 0.0 0.00028 20.8 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFC42229.1 - 0.022 14.9 0.0 0.03 14.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC42229.1 - 0.022 14.3 0.6 0.036 13.5 0.6 1.4 1 1 0 1 1 1 0 Putative acetyl-transferase OSCP PF00213.18 EFC42229.1 - 0.048 13.8 0.0 0.063 13.4 0.0 1.1 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit Acetyltransf_13 PF13880.6 EFC42229.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.7 EFC42229.1 - 0.19 12.4 0.0 0.22 12.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TPR_12 PF13424.6 EFC42230.1 - 4.4e-12 46.1 0.3 2e-08 34.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42230.1 - 2.1e-10 40.0 0.1 0.0005 19.8 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC42230.1 - 3.7e-07 29.8 3.9 0.053 13.4 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42230.1 - 7e-05 22.6 0.0 0.19 11.9 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC42230.1 - 0.00024 21.1 0.7 0.07 13.4 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42230.1 - 0.18 11.9 0.2 7.8 6.8 0.1 3.6 5 0 0 5 5 5 0 Tetratricopeptide repeat Homeobox_KN PF05920.11 EFC42231.1 - 4.1e-16 58.6 0.3 1.1e-15 57.3 0.3 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC42231.1 - 3.3e-09 36.4 0.2 8e-09 35.2 0.2 1.7 1 0 0 1 1 1 1 Homeodomain DUF1732 PF08340.11 EFC42232.1 - 0.12 12.4 0.0 0.12 12.4 0.0 2.3 3 1 1 4 4 4 0 Domain of unknown function (DUF1732) p450 PF00067.22 EFC42233.1 - 1e-76 258.6 0.1 7.9e-64 216.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 VPS9 PF02204.18 EFC42234.1 - 2.1e-13 50.4 0.9 3.5e-13 49.7 0.1 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain MscS_TM PF12794.7 EFC42235.1 - 0.52 9.1 2.4 0.69 8.7 2.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Peptidase_C70 PF12385.8 EFC42236.1 - 3.9e-11 43.1 0.0 0.00013 21.9 0.0 2.3 2 0 0 2 2 2 2 Papain-like cysteine protease AvrRpt2 Peptidase_C39_2 PF13529.6 EFC42236.1 - 5.7e-11 43.2 0.1 5.2e-09 36.8 0.1 2.2 1 1 0 1 1 1 1 Peptidase_C39 like family DUF3335 PF11814.8 EFC42236.1 - 0.0022 17.5 0.0 0.004 16.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase_C39 like family Guanylate_cyc_2 PF09778.9 EFC42236.1 - 0.0025 17.2 0.0 2.1 7.7 0.0 2.2 2 0 0 2 2 2 2 Guanylylate cyclase Peptidase_C39 PF03412.15 EFC42236.1 - 0.054 13.3 0.0 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 Peptidase C39 family SANT_DAMP1_like PF16282.5 EFC42237.1 - 8.3e-26 90.0 1.6 8.3e-26 90.0 1.6 2.5 3 0 0 3 3 3 1 SANT/Myb-like domain of DAMP1 Atg14 PF10186.9 EFC42237.1 - 0.45 9.5 12.3 0.89 8.6 12.3 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 EFC42237.1 - 2.2 7.8 8.2 3.3 7.2 8.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 EFC42237.1 - 3.4 5.5 9.2 5.2 4.9 9.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 EFC42237.1 - 3.7 6.2 5.9 0.45 9.2 1.6 1.6 2 0 0 2 2 2 0 Presenilin ORC_WH_C PF18137.1 EFC42237.1 - 4 7.5 14.8 17 5.5 8.9 3.0 2 1 1 3 3 3 0 Origin recognition complex winged helix C-terminal Atg8 PF02991.16 EFC42238.1 - 7e-38 129.0 0.2 8.6e-38 128.7 0.2 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EFC42238.1 - 0.0055 17.1 0.0 0.0093 16.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 GRAM PF02893.20 EFC42239.1 - 0.036 13.9 2.1 1 9.3 0.1 3.0 3 0 0 3 3 3 0 GRAM domain Ras PF00071.22 EFC42240.1 - 1.2e-24 86.7 0.1 2.8e-23 82.3 0.0 2.1 1 1 1 2 2 2 1 Ras family Roc PF08477.13 EFC42240.1 - 3.5e-12 46.6 0.0 6.4e-12 45.7 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PAP_central PF04928.17 EFC42240.1 - 0.031 13.2 2.4 0.051 12.5 2.4 1.3 1 0 0 1 1 1 0 Poly(A) polymerase central domain OKR_DC_1_N PF03709.15 EFC42240.1 - 0.036 14.3 0.1 0.49 10.7 0.0 2.1 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain DGCR6 PF07324.11 EFC42240.1 - 0.085 12.5 5.0 0.13 11.9 5.0 1.2 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein PRKCSH-like PF12999.7 EFC42240.1 - 0.56 10.0 4.0 1 9.1 4.0 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like SpoIIE PF07228.12 EFC42241.1 - 2.1e-11 44.1 0.0 3.1e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EFC42241.1 - 3.5e-08 33.4 0.0 0.00017 21.4 0.1 2.8 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFC42241.1 - 3.1e-05 23.7 0.0 6.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C Nucleoside_tran PF01733.18 EFC42242.1 - 4.6e-15 55.8 12.0 6.5e-13 48.7 0.7 3.1 1 1 2 3 3 3 3 Nucleoside transporter Ebp2 PF05890.12 EFC42243.1 - 2.9e-47 161.5 19.8 5.1e-47 160.7 19.8 1.4 1 0 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 LMBR1 PF04791.16 EFC42243.1 - 0.52 9.2 7.1 0.77 8.6 7.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Mago_nashi PF02792.14 EFC42243.1 - 1.6 8.9 8.3 0.38 10.9 0.7 2.3 2 0 0 2 2 2 0 Mago nashi protein DUF5339 PF17274.2 EFC42243.1 - 2.7 8.9 12.4 0.91 10.4 0.5 4.0 3 1 1 4 4 4 0 Family of unknown function (DUF5339) Arm PF00514.23 EFC42244.1 - 1.3e-09 37.7 0.1 0.24 11.5 0.0 6.6 6 1 0 6 6 6 2 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 EFC42244.1 - 1.3 9.3 4.8 76 3.6 0.1 4.3 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 HSCB_C PF07743.13 EFC42244.1 - 6.6 7.3 9.8 3.3 8.3 0.3 3.4 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain PMC2NT PF08066.12 EFC42244.1 - 7.2 7.4 9.2 1.5 9.6 2.0 3.5 2 1 1 3 3 3 0 PMC2NT (NUC016) domain PH PF00169.29 EFC42245.1 - 1.9e-09 38.0 2.4 1.9e-09 38.0 2.4 3.1 2 0 0 2 2 2 1 PH domain PBECR1 PF18809.1 EFC42245.1 - 0.067 13.9 1.8 2 9.1 0.7 3.6 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 DUF438 PF04282.13 EFC42245.1 - 5.4 7.1 7.9 24 4.9 7.9 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF438) EIF_2_alpha PF07541.12 EFC42246.1 - 5.9e-37 126.3 0.2 1.2e-36 125.3 0.1 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 EFC42246.1 - 1.1e-11 44.9 0.1 2.8e-11 43.6 0.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Daxx PF03344.15 EFC42246.1 - 0.047 13.8 0.0 0.096 12.8 0.0 1.5 1 0 0 1 1 1 0 Daxx N-terminal Rassf1C-interacting domain V-SNARE PF05008.15 EFC42246.1 - 0.068 13.6 1.7 10 6.6 0.0 3.6 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus ubiquitin PF00240.23 EFC42247.1 - 1.4e-62 207.3 6.1 2.7e-31 107.1 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC42247.1 - 1.3e-29 101.8 6.9 2e-14 53.2 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC42247.1 - 1.2e-08 35.3 2.9 0.003 18.0 0.5 3.0 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC42247.1 - 2.5e-08 34.0 0.2 0.0042 17.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC42247.1 - 6.1e-08 32.5 0.5 0.0059 16.5 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC42247.1 - 9.5e-08 32.3 1.1 0.007 16.7 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC42247.1 - 1.1e-07 32.3 0.1 0.0046 17.5 0.0 2.1 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC42247.1 - 0.00061 19.8 7.2 4.1 7.5 0.2 4.0 2 2 2 4 4 4 2 Ubiquitin-like domain DUF366 PF04017.12 EFC42247.1 - 0.01 15.4 0.0 0.78 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF366) PI3K_p85B PF02192.16 EFC42247.1 - 0.028 14.1 0.3 2.9 7.7 0.1 2.3 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain DUF3861 PF12977.7 EFC42247.1 - 0.042 14.0 0.3 3.2 8.0 0.0 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC42247.1 - 0.088 13.2 2.2 2.1 8.8 0.3 3.0 2 1 1 3 3 3 0 Bacterial PH domain ProRS-C_2 PF09181.10 EFC42247.1 - 0.099 12.8 0.5 12 6.1 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PilN_bio_d PF18222.1 EFC42247.1 - 0.14 12.6 0.1 5.2 7.5 0.0 2.1 2 0 0 2 2 2 0 PilN biogenesis protein dimerization domain Coagulin PF02035.15 EFC42247.1 - 0.19 11.6 0.3 6 6.7 0.0 2.2 2 0 0 2 2 2 0 Coagulin Pkinase PF00069.25 EFC42248.1 - 2.2e-08 33.8 4.8 4.2e-08 32.9 4.8 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC42248.1 - 3.2e-06 26.2 0.4 6.6e-06 25.2 0.4 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC42248.1 - 0.00051 19.4 0.3 0.00096 18.6 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFC42248.1 - 0.011 15.3 0.8 0.027 14.1 0.8 1.6 1 0 0 1 1 1 0 RIO1 family Pkinase_Tyr PF07714.17 EFC42248.1 - 0.013 14.8 1.0 0.025 13.9 1.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Orbi_VP7 PF00897.17 EFC42249.1 - 0.12 11.4 0.1 0.16 10.9 0.1 1.2 1 0 0 1 1 1 0 Orbivirus inner capsid protein VP7 Ribosomal_L10 PF00466.20 EFC42250.1 - 1.1e-20 73.6 3.7 1.1e-20 73.6 3.7 1.8 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFC42250.1 - 2.2e-17 62.8 0.6 5e-17 61.7 0.4 1.7 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 EFC42250.1 - 4.7e-13 49.5 5.6 4.7e-13 49.5 5.6 2.4 2 0 0 2 2 2 1 60s Acidic ribosomal protein YjcQ PF09639.10 EFC42250.1 - 0.047 13.9 0.8 0.12 12.6 0.8 1.7 1 0 0 1 1 1 0 YjcQ protein HEXIM PF15313.6 EFC42250.1 - 0.16 12.2 0.1 0.16 12.2 0.1 1.6 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein DUF3682 PF12446.8 EFC42250.1 - 0.22 12.0 1.7 0.51 10.8 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Renin_r PF07850.14 EFC42252.1 - 0.0096 16.5 0.1 0.0096 16.5 0.1 3.8 4 2 1 5 5 5 1 Renin receptor-like protein TarH PF02203.15 EFC42252.1 - 0.21 11.5 0.0 0.21 11.5 0.0 3.6 2 1 1 3 3 3 0 Tar ligand binding domain homologue Phage_holin_3_6 PF07332.11 EFC42252.1 - 0.85 9.7 29.7 0.14 12.2 5.8 4.1 2 1 2 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III DNA_pol_A_exo1 PF01612.20 EFC42253.1 - 0.0023 17.7 0.9 0.075 12.7 0.2 2.9 1 1 1 2 2 2 1 3'-5' exonuclease GRAM PF02893.20 EFC42253.1 - 0.026 14.4 0.2 0.026 14.4 0.2 5.2 6 1 0 6 6 6 0 GRAM domain GRIM-19 PF06212.12 EFC42254.1 - 4.3e-33 114.1 0.6 5.2e-33 113.8 0.6 1.1 1 0 0 1 1 1 1 GRIM-19 protein A_deaminase PF00962.22 EFC42254.1 - 0.025 13.9 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 Adenosine/AMP deaminase Macro PF01661.21 EFC42255.1 - 3.9e-23 81.7 0.6 1.1e-22 80.3 0.0 2.2 2 0 0 2 2 2 1 Macro domain PARP PF00644.20 EFC42255.1 - 2.4e-19 69.7 1.8 1.1e-18 67.5 0.7 2.8 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 EFC42255.1 - 9.1e-14 51.8 13.1 2.8e-08 34.2 5.2 3.9 4 0 0 4 4 4 2 WWE domain ChlI PF13541.6 EFC42255.1 - 0.07 13.0 0.1 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 Subunit ChlI of Mg-chelatase G-alpha PF00503.20 EFC42256.1 - 1.3e-72 244.9 13.3 1.3e-72 244.9 13.3 1.8 2 0 0 2 2 2 1 G-protein alpha subunit Arf PF00025.21 EFC42256.1 - 0.0012 18.3 0.1 0.22 11.0 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family NOG1 PF06858.14 EFC42256.1 - 0.079 12.8 0.8 14 5.5 0.0 2.7 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 EFC42256.1 - 0.087 12.9 0.0 14 5.8 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EFC42256.1 - 0.14 11.9 0.4 0.58 9.9 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation LSM PF01423.22 EFC42257.1 - 4.4e-15 55.1 0.9 8.4e-15 54.2 0.3 1.7 2 0 0 2 2 2 1 LSM domain Sec3_C PF09763.9 EFC42257.1 - 0.033 12.6 3.2 0.036 12.5 3.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 DUF3276 PF11680.8 EFC42257.1 - 0.033 14.3 0.2 0.046 13.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) DUF4834 PF16118.5 EFC42257.1 - 0.15 13.0 4.2 0.22 12.5 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Macoilin PF09726.9 EFC42257.1 - 1.3 7.5 6.6 1.4 7.4 6.6 1.0 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EFC42257.1 - 1.8 7.3 3.6 2.1 7.0 3.6 1.1 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 EFC42257.1 - 6.6 5.0 7.4 8 4.7 7.4 1.1 1 0 0 1 1 1 0 Menin Glucosamine_iso PF01182.20 EFC42258.1 - 2.6e-39 135.4 0.0 3.4e-39 135.0 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF1077 PF06417.12 EFC42258.1 - 0.11 12.5 0.1 0.37 10.8 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1077) Ras PF00071.22 EFC42259.1 - 1.4e-55 187.3 0.1 1.6e-55 187.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC42259.1 - 1.2e-21 77.1 0.0 1.8e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC42259.1 - 1.8e-11 43.8 0.1 2.2e-11 43.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC42259.1 - 9.7e-07 28.5 0.2 3.7e-06 26.6 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFC42259.1 - 7.2e-06 25.6 0.4 1.8e-05 24.3 0.4 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFC42259.1 - 2e-05 24.7 0.1 5.3e-05 23.3 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC42259.1 - 0.00011 22.2 0.1 0.053 13.4 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EFC42259.1 - 0.0017 18.2 2.5 0.012 15.5 0.1 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 EFC42259.1 - 0.0031 17.0 0.0 0.0039 16.7 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC42259.1 - 0.02 14.1 0.5 1.6 7.8 0.1 2.3 1 1 1 2 2 2 0 G-protein alpha subunit NB-ARC PF00931.22 EFC42259.1 - 0.049 12.8 0.3 0.2 10.8 0.0 1.9 3 0 0 3 3 3 0 NB-ARC domain Rhabdo_M2 PF04785.12 EFC42260.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus matrix protein M2 BORCS6 PF10157.9 EFC42261.1 - 4.7e-14 52.9 4.1 6e-14 52.5 4.1 1.1 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 Fzo_mitofusin PF04799.13 EFC42261.1 - 0.016 14.7 0.7 0.016 14.7 0.7 2.2 1 1 1 2 2 2 0 fzo-like conserved region MCU PF04678.13 EFC42261.1 - 7.9 6.5 7.8 34 4.5 7.8 1.9 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Asp_Arg_Hydrox PF05118.15 EFC42262.1 - 2.9e-39 134.4 0.4 1.1e-38 132.6 0.0 2.1 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase Mob1_phocein PF03637.17 EFC42263.1 - 1.3e-69 233.5 0.4 1.7e-69 233.2 0.4 1.1 1 0 0 1 1 1 1 Mob1/phocein family Ependymin PF00811.18 EFC42264.1 - 1.1e-13 51.5 0.3 2e-13 50.7 0.3 1.4 1 0 0 1 1 1 1 Ependymin Ank_2 PF12796.7 EFC42265.1 - 1.5e-08 35.1 0.1 2.6e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC42265.1 - 8.4e-07 29.2 0.3 0.0043 17.3 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC42265.1 - 4.1e-06 27.2 4.2 0.0017 18.9 0.3 2.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42265.1 - 1.6e-05 24.9 0.3 0.019 15.5 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 EFC42265.1 - 0.008 16.6 0.1 6.3 7.4 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat FtsK_alpha PF17854.1 EFC42266.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.5 1 1 1 2 2 2 0 FtsK alpha domain DUF5093 PF17011.5 EFC42266.1 - 0.045 14.1 0.2 0.063 13.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5093) MFS_1 PF07690.16 EFC42267.1 - 2.6e-32 112.1 34.5 1.1e-24 87.1 15.3 2.7 1 1 2 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EFC42267.1 - 1e-21 77.5 7.5 1.9e-21 76.7 7.5 1.4 1 0 0 1 1 1 1 Nodulin-like V_ATPase_I PF01496.19 EFC42267.1 - 0.0022 16.0 0.0 0.0022 16.0 0.0 2.0 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family Dpy-30 PF05186.13 EFC42268.1 - 1.3e-18 66.4 0.3 2.2e-18 65.6 0.3 1.4 1 0 0 1 1 1 1 Dpy-30 motif DpnI_C PF17726.1 EFC42268.1 - 0.017 15.2 1.4 0.07 13.3 1.4 2.0 1 0 0 1 1 1 0 Dam-replacing HTH domain Tricorn_C1 PF14684.6 EFC42268.1 - 0.098 12.7 0.6 3.7 7.7 0.0 2.4 2 0 0 2 2 2 0 Tricorn protease C1 domain Ashwin PF15323.6 EFC42268.1 - 0.79 9.7 13.8 1.5 8.8 5.7 2.2 2 0 0 2 2 2 0 Developmental protein Laminin_I PF06008.14 EFC42269.1 - 0.0007 19.4 15.2 0.0015 18.3 14.7 1.8 1 1 1 2 2 2 1 Laminin Domain I Cor1 PF04803.12 EFC42269.1 - 0.013 15.7 27.3 0.079 13.2 12.8 2.8 2 1 1 3 3 3 0 Cor1/Xlr/Xmr conserved region MADF_DNA_bdg PF10545.9 EFC42269.1 - 0.026 14.8 22.9 3.7 7.9 6.4 5.3 2 1 2 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like ApoLp-III PF07464.11 EFC42269.1 - 0.031 14.4 14.6 0.24 11.5 5.5 2.5 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) OmpH PF03938.14 EFC42269.1 - 0.054 13.8 26.5 2 8.8 9.2 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Mt_ATP-synt_D PF05873.12 EFC42269.1 - 0.53 10.1 31.9 1.8 8.4 10.1 4.0 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) EspB PF05802.11 EFC42269.1 - 0.61 10.0 13.3 16 5.5 13.3 2.6 1 1 0 1 1 1 0 Enterobacterial EspB protein Mitofilin PF09731.9 EFC42269.1 - 0.76 8.5 24.4 1 8.1 24.4 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF1993 PF09351.10 EFC42269.1 - 0.89 9.7 5.3 2.3 8.3 1.9 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF1993) AcylCoA_dehyd_C PF12186.8 EFC42269.1 - 0.92 9.7 16.0 1.5 8.9 4.7 3.1 1 1 2 3 3 3 0 Acyl-CoA dehydrogenase C terminal DUF883 PF05957.13 EFC42269.1 - 1 10.0 15.6 0.51 11.0 2.8 3.4 2 1 2 4 4 3 0 Bacterial protein of unknown function (DUF883) DUF948 PF06103.11 EFC42269.1 - 1.2 9.4 7.8 94 3.4 5.1 3.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Noelin-1 PF12308.8 EFC42269.1 - 2.4 8.2 11.7 1.6 8.8 7.0 2.6 1 1 2 3 3 3 0 Neurogenesis glycoprotein SOAR PF16533.5 EFC42269.1 - 2.7 8.0 16.5 4.3 7.4 0.6 3.0 1 1 2 3 3 3 0 STIM1 Orai1-activating region ApoO PF09769.9 EFC42269.1 - 3 7.8 6.8 20 5.2 3.0 3.1 2 1 1 3 3 3 0 Apolipoprotein O Retrotrans_gag PF03732.17 EFC42269.1 - 4 7.8 9.6 1.2e+02 3.0 6.4 3.5 1 1 1 2 2 2 0 Retrotransposon gag protein Peptidase_C98 PF15499.6 EFC42269.1 - 9.5 5.6 13.4 0.45 9.9 3.4 2.5 1 1 2 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF4407 PF14362.6 EFC42269.1 - 10 5.4 20.8 0.91 8.8 15.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Pam16 PF03656.13 EFC42270.1 - 0.00039 20.4 2.4 0.0024 17.9 2.4 1.9 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 EFC42270.1 - 0.00059 19.9 0.0 0.00085 19.4 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain DHR-2 PF06920.13 EFC42271.1 - 6.7e-85 285.7 13.3 6.7e-85 285.7 13.3 3.1 3 0 0 3 3 3 1 Dock homology region 2 Ank_2 PF12796.7 EFC42271.1 - 1.8e-05 25.3 0.0 5.7e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC42271.1 - 0.00073 19.8 0.0 0.0021 18.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC42271.1 - 0.063 13.9 0.0 0.18 12.4 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42271.1 - 0.079 13.6 0.0 4.5 8.2 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeat TPR_2 PF07719.17 EFC42271.1 - 0.094 12.9 0.8 0.31 11.2 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-CSL PF05207.13 EFC42272.1 - 8.9 6.1 11.1 24 4.7 6.2 2.7 2 1 0 2 2 2 0 CSL zinc finger Fz PF01392.22 EFC42274.1 - 0.0011 19.6 8.0 0.0014 19.2 8.0 1.2 1 0 0 1 1 1 1 Fz domain N_methyl PF07963.12 EFC42274.1 - 0.089 12.4 0.1 0.089 12.4 0.1 1.6 2 0 0 2 2 2 0 Prokaryotic N-terminal methylation motif BRE PF06113.12 EFC42275.1 - 3.1e-13 49.3 5.6 7.6e-13 48.0 5.6 1.5 1 1 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) Arb1 PF09692.10 EFC42275.1 - 0.037 13.2 0.1 0.094 11.9 0.0 1.6 2 0 0 2 2 2 0 Argonaute siRNA chaperone (ARC) complex subunit Arb1 SARS_3b PF12383.8 EFC42275.1 - 0.069 13.3 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Severe acute respiratory syndrome coronavirus 3b protein Translat_reg PF01818.17 EFC42276.1 - 0.18 11.8 0.1 6.3 6.8 0.1 2.5 2 0 0 2 2 2 0 Bacteriophage translational regulator Methyltransf_28 PF02636.17 EFC42277.1 - 1.5e-60 205.0 0.0 1.9e-60 204.7 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Acetyltransf_3 PF13302.7 EFC42278.1 - 2.2e-07 31.6 0.0 3.3e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC42278.1 - 0.0012 19.1 0.0 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Formyl_trans_N PF00551.19 EFC42279.1 - 4.5e-24 85.2 0.0 1.5e-23 83.5 0.0 2.0 1 1 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 EFC42279.1 - 1.4e-10 41.2 0.0 4.1e-10 39.8 0.0 1.9 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain Sel1 PF08238.12 EFC42280.1 - 4.8e-51 170.0 25.1 1.5e-09 38.2 0.6 7.4 7 1 0 7 7 7 7 Sel1 repeat TPR_20 PF14561.6 EFC42280.1 - 1.5e-05 25.2 5.1 0.028 14.7 0.0 4.5 3 2 2 5 5 5 1 Tetratricopeptide repeat WW_like PF17890.1 EFC42280.1 - 0.088 12.9 1.2 3.7 7.7 0.1 3.4 4 0 0 4 4 4 0 Peptidoglycan hydrolase LytB WW-like domain TPR_11 PF13414.6 EFC42280.1 - 0.17 11.6 20.8 1.5 8.6 0.2 6.2 5 2 1 6 6 6 0 TPR repeat TPR_7 PF13176.6 EFC42280.1 - 0.4 10.8 3.0 8.4 6.7 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_11 PF08241.12 EFC42282.1 - 1.9e-15 57.3 0.0 5.8e-14 52.5 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC42282.1 - 5.1e-11 43.2 1.0 9.8e-09 35.9 0.0 3.5 2 2 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC42282.1 - 5.6e-11 43.0 0.0 5.7e-07 30.1 0.0 2.6 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 EFC42282.1 - 3.4e-08 33.4 0.0 0.0016 18.3 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 EFC42282.1 - 5e-08 33.0 0.0 9.1e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC42282.1 - 5.5e-07 29.2 0.0 9.4e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 EFC42282.1 - 0.0012 18.8 0.0 0.0074 16.2 0.0 2.1 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 EFC42282.1 - 0.0075 14.9 0.0 2.7 6.4 0.0 2.1 2 0 0 2 2 2 2 Putative S-adenosyl-L-methionine-dependent methyltransferase N6_N4_Mtase PF01555.18 EFC42282.1 - 0.0076 16.0 0.0 2.9 7.6 0.0 2.4 2 1 0 2 2 2 2 DNA methylase Rac1 PF09632.10 EFC42282.1 - 0.042 13.0 0.0 0.07 12.3 0.0 1.4 1 0 0 1 1 1 0 Rac1-binding domain Pex14_N PF04695.13 EFC42283.1 - 0.012 16.2 3.4 0.012 16.2 3.4 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Mucin PF01456.17 EFC42283.1 - 0.24 11.4 10.9 0.44 10.5 10.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 EFC42283.1 - 0.9 10.0 10.0 1.6 9.2 10.0 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MID_MedPIWI PF18296.1 EFC42283.1 - 1.2 8.9 9.8 0.19 11.5 5.5 1.7 2 0 0 2 2 2 0 MID domain of medPIWI Ribosomal_L5e PF17144.4 EFC42284.1 - 8.8e-83 276.2 0.2 8.8e-83 276.2 0.2 1.8 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 EFC42284.1 - 3.1e-28 98.6 10.1 3.1e-28 98.6 10.1 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region PriX PF18689.1 EFC42284.1 - 0.052 13.9 0.9 0.13 12.7 0.9 1.6 1 0 0 1 1 1 0 Primase X GNT-I PF03071.15 EFC42285.1 - 7.8e-96 321.5 1.0 1e-95 321.1 1.0 1.0 1 0 0 1 1 1 1 GNT-I family SAPS PF04499.15 EFC42287.1 - 1.2e-29 103.4 17.6 3.2e-21 75.7 0.3 2.8 3 0 0 3 3 3 2 SIT4 phosphatase-associated protein LRR_6 PF13516.6 EFC42288.1 - 5.9e-10 38.4 8.7 0.14 12.3 0.1 5.5 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 EFC42288.1 - 0.28 11.7 9.3 1.3 9.5 0.1 4.9 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) Fuseless PF15993.5 EFC42289.1 - 1.1e-13 51.0 12.3 8.5e-08 31.7 2.3 2.1 2 0 0 2 2 2 2 Fuseless DctQ PF04290.12 EFC42289.1 - 0.38 10.7 9.1 0.69 9.8 0.9 2.3 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF4795 PF16043.5 EFC42290.1 - 7e-07 29.0 17.6 7e-07 29.0 17.6 5.7 4 4 0 4 4 4 1 Domain of unknown function (DUF4795) Shugoshin_N PF07558.11 EFC42290.1 - 0.13 12.2 0.1 0.13 12.2 0.1 2.6 3 0 0 3 3 3 0 Shugoshin N-terminal coiled-coil region HIP1_clath_bdg PF16515.5 EFC42290.1 - 0.45 11.2 0.1 0.41 11.3 1.3 6.7 6 0 0 6 6 6 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Matrilin_ccoil PF10393.9 EFC42290.1 - 0.55 10.1 10.0 1.3 8.9 0.0 4.4 4 0 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin Laminin_II PF06009.12 EFC42290.1 - 0.66 10.0 50.6 0.33 11.0 2.8 6.9 5 2 1 6 6 6 0 Laminin Domain II Phage_pRha PF09669.10 EFC42290.1 - 0.97 10.0 7.6 0.3 11.7 0.4 3.8 2 1 2 4 4 4 0 Phage regulatory protein Rha (Phage_pRha) Vac_Fusion PF02346.16 EFC42290.1 - 1.9 8.2 9.1 7.6 6.2 0.1 4.3 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Pox_A_type_inc PF04508.12 EFC42290.1 - 2.8 7.9 10.8 12 5.9 0.2 5.0 3 1 1 4 4 4 0 Viral A-type inclusion protein repeat DASH_Dam1 PF08653.10 EFC42290.1 - 3.9 7.4 11.6 5.8 6.8 1.0 3.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 TSC22 PF01166.18 EFC42290.1 - 5.4 7.4 10.3 3 8.2 0.9 4.3 4 0 0 4 4 3 0 TSC-22/dip/bun family LIF_OSM PF01291.17 EFC42290.1 - 7 6.8 9.0 0.91 9.6 0.2 3.5 3 1 0 3 3 3 0 LIF / OSM family DIOX_N PF14226.6 EFC42290.1 - 8 7.2 8.1 1.8 9.3 0.2 3.3 3 0 0 3 3 3 0 non-haem dioxygenase in morphine synthesis N-terminal VASt PF16016.5 EFC42292.1 - 5.2e-22 78.9 0.1 1.7e-21 77.2 0.1 1.9 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 EFC42292.1 - 8.8e-22 77.1 1.2 8.8e-22 77.1 1.2 1.8 2 0 0 2 2 2 1 GRAM domain DUF1548 PF07579.11 EFC42292.1 - 0.027 14.8 3.6 0.1 12.9 3.6 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) PH_BEACH PF14844.6 EFC42292.1 - 0.07 13.2 0.0 0.07 13.2 0.0 4.5 3 1 1 4 4 4 0 PH domain associated with Beige/BEACH Utp14 PF04615.13 EFC42292.1 - 3.3 6.2 47.3 0.075 11.6 33.7 2.8 2 1 0 2 2 2 0 Utp14 protein HSP20 PF00011.21 EFC42293.1 - 3.2e-24 85.0 1.5 4.3e-24 84.6 1.5 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC42293.1 - 1.4e-06 27.7 0.0 2.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFC42293.1 - 0.023 15.7 0.6 0.16 13.0 0.4 2.0 1 1 1 2 2 2 0 CS domain FKBP26_C PF18046.1 EFC42293.1 - 0.036 14.1 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 FKBP26_C-terminal HSP20 PF00011.21 EFC42295.1 - 3.2e-24 85.0 1.5 4.3e-24 84.6 1.5 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC42295.1 - 1.4e-06 27.7 0.0 2.2e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 EFC42295.1 - 0.023 15.7 0.6 0.16 13.0 0.4 2.0 1 1 1 2 2 2 0 CS domain FKBP26_C PF18046.1 EFC42295.1 - 0.036 14.1 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 FKBP26_C-terminal DUF4116 PF13475.6 EFC42296.1 - 2.3e-51 171.3 12.2 9.7e-16 57.2 0.0 7.6 3 2 4 8 8 8 8 Domain of unknown function (DUF4116) DUF3206 PF11472.8 EFC42296.1 - 0.043 13.8 2.4 0.058 13.4 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3206) Epimerase PF01370.21 EFC42298.1 - 2.1e-20 73.2 0.2 3.3e-20 72.6 0.2 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC42298.1 - 2.6e-18 66.0 0.2 3.2e-18 65.7 0.2 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFC42298.1 - 5.8e-17 62.2 0.0 8.4e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EFC42298.1 - 1.9e-10 40.3 0.1 6.1e-09 35.4 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EFC42298.1 - 3.2e-10 39.9 0.2 6.3e-10 39.0 0.2 1.5 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 EFC42298.1 - 2.2e-06 27.0 0.0 3.2e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFC42298.1 - 8.4e-05 22.1 0.4 0.00014 21.4 0.4 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EFC42298.1 - 0.03 13.8 0.1 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 short chain dehydrogenase DXP_redisom_C PF08436.12 EFC42298.1 - 0.058 13.5 0.0 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal domain KR PF08659.10 EFC42298.1 - 0.076 12.9 0.1 0.78 9.6 0.1 2.1 1 1 0 1 1 1 0 KR domain Semialdhyde_dh PF01118.24 EFC42298.1 - 0.079 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain PseudoU_synth_1 PF01416.20 EFC42299.1 - 1.5e-33 115.4 0.0 5.3e-29 100.8 0.0 2.5 2 1 0 2 2 2 2 tRNA pseudouridine synthase RWP-RK PF02042.15 EFC42300.1 - 3.3e-10 39.8 0.0 7.6e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 RWP-RK domain HTH_8 PF02954.19 EFC42300.1 - 0.013 15.3 0.2 0.023 14.5 0.2 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_Tnp_ISL3 PF13542.6 EFC42300.1 - 0.018 14.5 0.0 0.033 13.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 RWP-RK PF02042.15 EFC42301.1 - 2.2e-08 34.0 0.1 5e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 RWP-RK domain CDK5_activator PF03261.15 EFC42301.1 - 0.094 12.2 12.9 0.14 11.7 12.9 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Macoilin PF09726.9 EFC42301.1 - 0.86 8.1 14.3 0.98 7.9 14.3 1.1 1 0 0 1 1 1 0 Macoilin family SNF2_N PF00176.23 EFC42302.1 - 5.1e-38 130.7 0.0 9e-38 129.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC42302.1 - 1.9e-11 44.2 0.0 3.4e-10 40.3 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC42302.1 - 1.5e-08 34.8 0.0 1e-07 32.1 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFC42302.1 - 0.00096 18.1 0.0 0.0017 17.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 SWI2_SNF2 PF18766.1 EFC42302.1 - 0.0066 16.1 0.0 0.16 11.6 0.0 2.6 2 1 0 2 2 2 1 SWI2/SNF2 ATPase NOA36 PF06524.12 EFC42302.1 - 8.4 5.6 9.5 15 4.8 9.5 1.4 1 0 0 1 1 1 0 NOA36 protein Vac7 PF12751.7 EFC42303.1 - 0.0061 16.1 0.1 0.0072 15.8 0.1 1.1 1 0 0 1 1 1 1 Vacuolar segregation subunit 7 Cathelicidins PF00666.17 EFC42303.1 - 0.082 13.2 0.1 0.22 11.8 0.1 1.7 1 1 0 1 1 1 0 Cathelicidin Suv3_N PF18114.1 EFC42304.1 - 0.0056 16.8 1.0 0.013 15.6 1.0 1.6 1 0 0 1 1 1 1 Suv3 helical N-terminal domain YscJ_FliF PF01514.17 EFC42304.1 - 0.11 12.2 0.9 0.27 10.9 0.9 1.6 1 0 0 1 1 1 0 Secretory protein of YscJ/FliF family Orf78 PF06024.12 EFC42304.1 - 0.71 10.2 5.2 0.14 12.5 1.1 2.0 2 0 0 2 2 2 0 Orf78 (ac78) NicO PF03824.16 EFC42306.1 - 0.014 14.8 0.2 0.017 14.4 0.2 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein Skp1_POZ PF03931.15 EFC42306.1 - 0.077 13.2 0.0 0.25 11.5 0.0 1.9 1 1 0 1 1 1 0 Skp1 family, tetramerisation domain DUF3829 PF12889.7 EFC42306.1 - 0.19 11.2 8.5 0.17 11.3 2.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) RYDR_ITPR PF01365.21 EFC42308.1 - 3.2e-27 95.3 18.6 3.7e-20 72.2 2.8 4.8 4 0 0 4 4 4 2 RIH domain RIH_assoc PF08454.11 EFC42308.1 - 9.8e-20 70.3 0.7 9.8e-20 70.3 0.7 6.1 5 1 1 6 6 6 2 RyR and IP3R Homology associated Ins145_P3_rec PF08709.11 EFC42308.1 - 6e-18 64.8 3.3 3.2e-17 62.5 2.3 2.4 1 1 0 2 2 2 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 EFC42308.1 - 4.5e-15 56.0 4.6 1.6e-11 44.4 1.0 3.8 3 0 0 3 3 3 2 MIR domain Ion_trans PF00520.31 EFC42308.1 - 2.5e-07 30.2 20.1 2.5e-07 30.2 20.1 2.4 2 1 0 2 2 2 1 Ion transport protein LRR_6 PF13516.6 EFC42309.1 - 1.2e-13 49.9 47.6 0.036 14.1 0.2 12.7 12 1 0 12 12 12 7 Leucine Rich repeat LRR_4 PF12799.7 EFC42309.1 - 1.4e-13 50.8 57.7 0.0032 17.8 1.5 8.4 4 2 5 9 9 9 9 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC42309.1 - 0.00022 20.8 12.0 0.072 12.6 0.3 3.5 1 1 1 3 3 3 2 Leucine-rich repeat F-box-like PF12937.7 EFC42309.1 - 0.0026 17.6 0.2 0.0061 16.4 0.2 1.5 1 0 0 1 1 1 1 F-box-like Crust_neurohorm PF01147.17 EFC42309.1 - 0.15 11.9 2.3 0.7 9.8 0.0 2.9 3 0 0 3 3 3 0 Crustacean CHH/MIH/GIH neurohormone family LRR_8 PF13855.6 EFC42309.1 - 0.49 10.2 50.6 2.4 8.0 2.2 7.9 3 3 4 7 7 7 0 Leucine rich repeat Guanylate_cyc PF00211.20 EFC42310.1 - 4.5e-53 179.6 0.4 9.6e-53 178.5 0.4 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC42310.1 - 1.4e-12 47.8 0.0 4.3e-12 46.2 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC42310.1 - 0.0046 16.9 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold DUF3939 PF13075.6 EFC42310.1 - 0.0055 16.7 0.1 0.021 14.8 0.1 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3939) PAS_4 PF08448.10 EFC42310.1 - 0.024 14.9 0.0 0.055 13.7 0.0 1.5 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC42310.1 - 0.045 13.2 0.1 0.098 12.1 0.1 1.6 1 0 0 1 1 1 0 Heme NO binding associated PAS_8 PF13188.7 EFC42310.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 PAS domain dsDNA_bind PF01984.20 EFC42310.1 - 0.16 12.3 1.3 0.31 11.4 0.1 2.1 2 0 0 2 2 2 0 Double-stranded DNA-binding domain PH PF00169.29 EFC42311.1 - 6.6e-24 84.4 15.3 1.1e-12 48.4 0.4 4.2 3 1 0 3 3 3 2 PH domain PH_11 PF15413.6 EFC42311.1 - 3.8e-08 33.7 14.1 0.00051 20.4 4.6 3.8 3 1 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 EFC42311.1 - 6.7e-05 23.1 1.0 0.77 10.1 0.0 3.4 4 0 0 4 4 4 2 Pleckstrin homology domain PH_9 PF15410.6 EFC42311.1 - 0.008 16.5 8.1 0.37 11.2 0.4 4.9 4 1 0 4 4 4 1 Pleckstrin homology domain Ribosomal_L4 PF00573.22 EFC42312.1 - 2.5e-54 183.9 0.3 6e-52 176.1 0.0 2.1 1 1 1 2 2 2 2 Ribosomal protein L4/L1 family DUF2058 PF09831.9 EFC42312.1 - 0.072 13.2 0.2 3.3 7.8 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) SR-25 PF10500.9 EFC42313.1 - 0.0018 17.9 11.9 0.0018 17.9 11.9 3.0 2 1 2 4 4 4 1 Nuclear RNA-splicing-associated protein SulA PF03846.14 EFC42313.1 - 0.027 14.4 1.9 0.043 13.8 0.2 2.2 2 0 0 2 2 2 0 Cell division inhibitor SulA Methyltransf_FA PF12248.8 EFC42313.1 - 0.21 12.0 0.2 0.21 12.0 0.2 2.9 3 0 0 3 3 3 0 Farnesoic acid 0-methyl transferase CN_hydrolase PF00795.22 EFC42314.1 - 1.6e-08 34.2 0.0 2.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Tenui_NS4 PF03300.13 EFC42314.1 - 0.042 13.3 0.2 0.084 12.3 0.2 1.4 1 0 0 1 1 1 0 Tenuivirus non-structural, movement protein NS4 DUF3682 PF12446.8 EFC42314.1 - 0.11 13.0 0.2 0.22 12.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Methyltransf_25 PF13649.6 EFC42315.1 - 0.011 16.4 0.0 0.025 15.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFC42315.1 - 0.058 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFC42315.1 - 0.15 12.9 0.1 1.2 9.9 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Kinesin PF00225.23 EFC42316.1 - 3.6e-109 364.7 14.1 1.1e-108 363.1 14.1 1.7 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC42316.1 - 1.5e-26 93.1 4.6 7.3e-26 90.9 4.6 2.1 1 1 0 1 1 1 1 Microtubule binding ANAPC4_WD40 PF12894.7 EFC42317.1 - 5.8e-07 29.7 0.2 0.015 15.6 0.0 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC42317.1 - 0.00067 20.4 0.0 0.052 14.4 0.0 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 EFC42317.1 - 0.0061 15.3 0.3 3.4 6.2 0.0 2.8 3 0 0 3 3 3 2 Nucleoporin Nup120/160 NBD_C PF17042.5 EFC42317.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain Histone PF00125.24 EFC42318.1 - 2.3e-50 170.3 4.7 2.6e-50 170.2 4.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 EFC42318.1 - 1.7e-05 25.4 0.8 1.9e-05 25.3 0.8 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EFC42318.1 - 7.9e-05 22.7 0.3 7.9e-05 22.7 0.3 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFC42318.1 - 0.0003 21.1 0.1 0.00046 20.5 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFC42318.1 - 0.012 15.9 0.6 0.023 14.9 0.1 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFC42318.1 - 0.11 12.5 0.9 0.15 12.1 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit EGF_2 PF07974.13 EFC42319.1 - 1.4e-07 31.8 72.2 0.0053 17.1 14.0 5.6 5 0 0 5 5 5 4 EGF-like domain Tubulin PF00091.25 EFC42320.1 - 5.9e-64 215.9 0.0 1e-63 215.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC42320.1 - 5.3e-43 146.2 0.5 9.2e-43 145.4 0.5 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC42320.1 - 3.3e-06 26.9 0.0 7.7e-06 25.7 0.0 1.7 1 0 0 1 1 1 1 Tubulin domain UPF0047 PF01894.17 EFC42320.1 - 0.17 12.0 0.3 28 4.9 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0047 LRR_4 PF12799.7 EFC42321.1 - 5.8e-07 29.7 50.8 0.0011 19.4 3.2 9.1 3 3 5 9 9 9 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC42321.1 - 0.0013 18.5 3.5 0.0013 18.5 3.5 5.5 5 1 0 5 5 5 2 Leucine rich repeat F-box PF00646.33 EFC42321.1 - 0.0017 18.2 0.7 0.013 15.4 0.1 2.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC42321.1 - 0.0088 15.9 0.1 0.027 14.4 0.1 1.8 1 0 0 1 1 1 1 F-box-like Phage_AlpA PF05930.12 EFC42321.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) LRR_6 PF13516.6 EFC42321.1 - 0.22 11.7 22.4 0.12 12.5 1.1 7.1 8 0 0 8 8 8 0 Leucine Rich repeat Copine PF07002.16 EFC42322.1 - 1.1e-08 34.8 1.4 4e-05 23.2 0.3 3.8 2 1 0 2 2 2 2 Copine CDO_I PF05995.12 EFC42323.1 - 1.6e-22 79.6 0.0 2.1e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I zinc-ribbon_6 PF10005.9 EFC42323.1 - 0.0048 17.5 0.8 0.015 16.0 0.3 2.0 1 1 1 2 2 2 1 zinc-ribbon domain LPD38 PF18857.1 EFC42323.1 - 0.045 13.9 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Large polyvalent protein associated domain 38 PCO_ADO PF07847.12 EFC42323.1 - 0.054 12.9 0.6 0.39 10.2 0.6 2.0 1 1 0 1 1 1 0 PCO_ADO Pkinase PF00069.25 EFC42324.1 - 3.8e-10 39.6 0.0 6.9e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42324.1 - 0.00018 20.9 0.0 0.00031 20.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase G5 PF07501.12 EFC42324.1 - 0.096 13.1 0.6 0.22 12.0 0.6 1.6 1 0 0 1 1 1 0 G5 domain Pkinase PF00069.25 EFC42325.1 - 3.6e-56 190.5 0.1 7e-56 189.5 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42325.1 - 7.8e-50 169.6 0.1 2.9e-48 164.4 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC42325.1 - 0.00024 20.0 0.2 0.00039 19.3 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC42325.1 - 0.012 14.6 0.3 0.13 11.2 0.3 2.3 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EFC42325.1 - 0.065 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC42325.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Chlam_PMP PF02415.17 EFC42325.1 - 0.26 11.8 17.3 0.28 11.8 0.9 5.6 4 1 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Tmemb_185A PF10269.9 EFC42326.1 - 6.8e-06 25.9 28.5 0.00022 21.0 12.7 2.8 3 0 0 3 3 3 2 Transmembrane Fragile-X-F protein Ykof PF07615.11 EFC42326.1 - 0.12 12.9 0.1 0.29 11.6 0.1 1.6 1 0 0 1 1 1 0 YKOF-related Family Guanylate_cyc PF00211.20 EFC42327.1 - 2.4e-21 76.2 0.2 4.5e-21 75.3 0.2 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DHHC PF01529.20 EFC42327.1 - 0.059 13.5 1.3 0.66 10.1 0.0 2.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase Peptidase_M14 PF00246.24 EFC42328.1 - 4.1e-17 62.9 0.0 1.6e-16 60.9 0.0 1.9 1 1 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 EFC42328.1 - 1.5e-15 57.5 0.2 3.8e-15 56.2 0.2 1.7 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain DAGK_cat PF00781.24 EFC42329.1 - 7.1e-21 74.1 0.0 2.1e-20 72.6 0.0 1.8 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain PH PF00169.29 EFC42329.1 - 0.011 16.3 0.0 0.035 14.6 0.0 1.9 1 0 0 1 1 1 0 PH domain FAM195 PF14799.6 EFC42329.1 - 0.4 11.0 2.7 0.26 11.7 0.2 2.0 2 0 0 2 2 2 0 FAM195 family EGF_2 PF07974.13 EFC42331.1 - 7.3e-47 157.4 240.0 8.2e-06 26.1 8.9 15.5 15 0 0 15 15 15 15 EGF-like domain RGS PF00615.19 EFC42331.1 - 1.1e-06 28.8 3.2 1.3e-06 28.7 1.2 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain EGF PF00008.27 EFC42331.1 - 0.0021 18.3 193.1 0.12 12.7 4.2 16.8 15 1 2 17 17 17 11 EGF-like domain Kelch_1 PF01344.25 EFC42331.1 - 0.1 12.2 11.7 1.5 8.5 0.0 5.2 5 0 0 5 5 5 0 Kelch motif Kelch_5 PF13854.6 EFC42331.1 - 0.94 9.5 16.7 0.79 9.8 0.7 4.3 5 0 0 5 5 5 0 Kelch motif HEAT PF02985.22 EFC42332.1 - 2.3e-11 42.9 0.4 0.061 13.6 0.0 6.0 5 0 0 5 5 5 2 HEAT repeat LisH PF08513.11 EFC42332.1 - 8.8e-08 31.8 2.3 0.0034 17.3 0.0 2.7 2 0 0 2 2 2 2 LisH HEAT_2 PF13646.6 EFC42332.1 - 9.6e-08 32.3 2.3 0.078 13.4 0.1 4.3 4 0 0 4 4 4 3 HEAT repeats Vac14_Fab1_bd PF12755.7 EFC42332.1 - 0.0022 18.5 0.3 3 8.5 0.0 4.1 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFC42332.1 - 0.0029 18.1 1.4 25 5.5 0.1 4.2 3 1 0 3 3 3 0 HEAT-like repeat PAP_central PF04928.17 EFC42332.1 - 0.0068 15.4 0.0 0.12 11.3 0.0 2.9 3 1 0 3 3 3 1 Poly(A) polymerase central domain Arm PF00514.23 EFC42332.1 - 0.038 14.0 0.7 26 5.0 0.1 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Alph_Pro_TM PF09608.10 EFC42332.1 - 0.09 12.6 0.3 0.18 11.6 0.3 1.4 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) YgbB PF02542.16 EFC42332.1 - 0.15 12.3 2.3 3.1 8.1 0.3 3.0 3 0 0 3 3 3 0 YgbB family TolA_bind_tri PF16331.5 EFC42332.1 - 0.36 11.0 16.8 0.058 13.5 0.9 3.9 2 1 1 3 3 3 0 TolA binding protein trimerisation PKcGMP_CC PF16808.5 EFC42332.1 - 0.98 9.3 15.7 0.33 10.8 7.2 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.12 EFC42332.1 - 1 10.0 10.2 1.6 9.4 1.2 3.7 3 0 0 3 3 2 0 SlyX Fez1 PF06818.15 EFC42332.1 - 1.3 9.4 21.0 0.41 11.1 8.4 2.9 2 0 0 2 2 2 0 Fez1 ADIP PF11559.8 EFC42332.1 - 2.4 8.2 17.2 6.1 6.9 6.2 3.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF745 PF05335.13 EFC42332.1 - 3 7.5 15.1 0.097 12.4 7.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) HrpB7 PF09486.10 EFC42332.1 - 9.4 6.6 8.0 50 4.2 3.1 2.6 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Rhodanese PF00581.20 EFC42333.1 - 7.2e-10 39.4 0.0 2e-09 37.9 0.0 1.8 1 1 0 1 1 1 1 Rhodanese-like domain DUF2892 PF11127.8 EFC42333.1 - 5.4e-08 32.8 1.1 9.4e-08 32.0 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2892) Ribosomal_L14 PF00238.19 EFC42333.1 - 0.078 13.1 0.1 0.28 11.3 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L14p/L23e zf-RING_2 PF13639.6 EFC42334.1 - 0.00034 20.9 13.0 0.00068 19.9 13.0 1.5 1 0 0 1 1 1 1 Ring finger domain Importin_rep_6 PF18829.1 EFC42335.1 - 0.037 14.2 1.5 0.075 13.2 0.1 2.3 2 0 0 2 2 2 0 Importin repeat 6 TraL PF07178.11 EFC42335.1 - 0.063 13.8 0.3 0.063 13.8 0.3 1.9 2 0 0 2 2 2 0 TraL protein MacB_PCD PF12704.7 EFC42335.1 - 0.13 12.6 1.3 2.8 8.2 0.1 2.5 2 0 0 2 2 2 0 MacB-like periplasmic core domain HisKA PF00512.25 EFC42336.1 - 4.5e-09 36.2 0.0 1.1e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c PF02518.26 EFC42338.1 - 3.2e-22 79.1 0.2 1.4e-21 77.1 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC42338.1 - 4e-19 68.8 0.1 6.2e-19 68.2 0.1 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_5 PF14501.6 EFC42338.1 - 0.004 17.0 0.5 0.024 14.5 0.0 2.5 2 2 0 2 2 2 1 GHKL domain GPCR_chapero_1 PF11904.8 EFC42338.1 - 0.057 12.8 0.1 0.071 12.5 0.1 1.1 1 0 0 1 1 1 0 GPCR-chaperone KRTAP PF11759.8 EFC42338.1 - 0.18 12.4 53.0 1.8e+04 -16.2 53.0 3.3 1 1 0 1 1 1 0 Keratin-associated matrix GST_C_3 PF14497.6 EFC42339.1 - 3.8e-05 23.8 0.0 8.5e-05 22.7 0.0 1.7 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC42339.1 - 0.00033 20.6 0.0 0.0006 19.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC42339.1 - 0.056 13.7 0.0 0.091 13.0 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF3007 PF11460.8 EFC42339.1 - 0.063 13.5 0.6 0.16 12.2 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) GST_C_6 PF17171.4 EFC42339.1 - 0.063 13.1 0.4 0.22 11.3 0.4 2.1 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain AAA PF00004.29 EFC42340.1 - 1.5e-30 106.4 0.0 2.7e-30 105.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC42340.1 - 1.3e-12 47.3 0.0 3.1e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EFC42340.1 - 6.1e-09 35.8 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MHCassoc_trimer PF08831.10 EFC42340.1 - 0.098 12.7 0.6 0.33 11.0 0.1 2.0 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain RPN13_C PF16550.5 EFC42341.1 - 4.1e-25 88.1 0.9 9.7e-25 86.9 0.1 2.0 2 1 0 2 2 2 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 EFC42341.1 - 2.9e-24 85.4 0.0 5.5e-24 84.5 0.0 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DUF1918 PF08940.11 EFC42341.1 - 0.029 14.0 0.1 0.096 12.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) GET2 PF08690.10 EFC42341.1 - 0.41 10.3 8.6 0.57 9.8 8.6 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 PNRC PF15365.6 EFC42342.1 - 4.2e-07 29.6 2.1 4.2e-07 29.6 2.1 2.9 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif SPOUT_MTase PF02590.17 EFC42342.1 - 0.49 10.4 3.4 1.1 9.2 3.4 1.5 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase DUF1676 PF07898.13 EFC42342.1 - 4.2 7.4 5.1 9.2 6.3 5.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) TPR_2 PF07719.17 EFC42343.1 - 9.2e-10 37.9 10.6 0.00052 19.9 0.0 4.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC42343.1 - 3.3e-09 37.1 0.0 0.00011 22.7 0.0 4.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC42343.1 - 8.5e-09 35.9 0.1 7.1e-06 26.6 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC42343.1 - 8.8e-09 34.9 0.1 3.5e-07 29.8 0.0 3.3 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.6 EFC42343.1 - 2.5e-08 34.0 0.4 0.0042 17.8 0.0 6.1 4 2 1 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC42343.1 - 1.8e-07 31.0 0.6 0.00059 20.0 0.1 4.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42343.1 - 2.7e-07 30.8 3.7 0.00024 21.4 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42343.1 - 3.2e-06 26.7 3.7 0.055 13.3 0.3 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC42343.1 - 1.5e-05 24.9 13.8 0.12 12.7 0.2 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFC42343.1 - 2.1e-05 23.9 1.6 0.00011 21.5 0.9 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC42343.1 - 0.014 16.0 1.0 0.23 12.2 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42343.1 - 0.018 15.0 1.9 21 5.5 0.1 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC42343.1 - 0.061 13.5 0.1 0.91 9.7 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC42343.1 - 0.073 13.3 7.3 0.047 13.9 1.5 3.3 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 RE_R_Pab1 PF09522.10 EFC42343.1 - 0.091 12.9 0.2 4.9 7.3 0.0 2.6 2 0 0 2 2 2 0 R.Pab1 restriction endonuclease DUF3151 PF11349.8 EFC42343.1 - 0.12 12.5 0.5 0.86 9.7 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3151) PepSY_TM_like_2 PF16357.5 EFC42343.1 - 0.15 12.0 0.8 0.26 11.2 0.1 1.7 2 0 0 2 2 2 0 Putative PepSY_TM-like TPR_10 PF13374.6 EFC42343.1 - 0.81 9.6 12.5 0.38 10.7 0.9 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat Clathrin PF00637.20 EFC42343.1 - 2.1 8.2 7.1 4.9 7.0 0.0 4.6 4 1 1 5 5 5 0 Region in Clathrin and VPS WD40 PF00400.32 EFC42344.1 - 7.8e-42 140.5 25.3 1.1e-07 32.4 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42344.1 - 2.4e-21 75.8 2.8 8.7e-05 22.8 0.1 6.4 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC42344.1 - 1.6e-07 31.4 5.7 0.0038 17.1 1.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFC42344.1 - 0.006 15.9 0.0 0.08 12.2 0.0 2.3 1 1 0 2 2 2 1 WD40-like domain FTHFS PF01268.19 EFC42345.1 - 1.7e-195 650.5 0.0 2.7e-162 540.8 0.0 2.0 1 1 1 2 2 2 2 Formate--tetrahydrofolate ligase Mob1_phocein PF03637.17 EFC42346.1 - 4.3e-56 189.6 0.2 6.4e-56 189.0 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family CKS PF01111.19 EFC42349.1 - 1.7e-31 108.3 1.6 2.4e-31 107.8 1.6 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit 2Fe-2S_thioredx PF01257.19 EFC42350.1 - 5.6e-53 178.7 0.2 7.1e-53 178.4 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin RIIa PF02197.17 EFC42350.1 - 0.022 14.4 0.2 0.46 10.2 0.0 2.4 2 0 0 2 2 2 0 Regulatory subunit of type II PKA R-subunit TPR_8 PF13181.6 EFC42351.1 - 6e-07 29.2 2.3 0.027 14.7 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42351.1 - 0.00018 21.4 2.1 1.5 9.1 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42351.1 - 0.0035 17.6 0.0 0.082 13.2 0.0 3.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42351.1 - 0.035 13.9 0.7 16 5.5 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TBCC_N PF16752.5 EFC42351.1 - 0.22 12.0 4.5 4.4 7.8 0.1 3.3 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain MCM_N PF14551.6 EFC42351.1 - 4 8.1 8.2 12 6.5 0.1 4.2 3 1 1 4 4 4 0 MCM N-terminal domain Acetyltransf_16 PF05301.11 EFC42352.1 - 4.2e-53 179.7 0.0 7.1e-53 178.9 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.7 EFC42352.1 - 0.0029 18.0 0.0 0.018 15.4 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Tn916-Xis PF09035.10 EFC42352.1 - 0.019 15.1 0.3 1.1 9.5 0.0 2.7 3 0 0 3 3 3 0 Excisionase from transposon Tn916 Acetyltransf_1 PF00583.25 EFC42352.1 - 0.02 15.1 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC42352.1 - 0.021 14.8 0.0 0.052 13.5 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FAM183 PF14886.6 EFC42353.1 - 0.087 13.5 8.8 0.44 11.3 2.0 2.0 1 1 1 2 2 2 0 FAM183A and FAM183B related Csm1_N PF18504.1 EFC42354.1 - 0.87 10.0 16.9 0.071 13.5 3.1 3.6 2 1 1 3 3 3 0 Csm1 N-terminal domain DUF4164 PF13747.6 EFC42354.1 - 1.3 9.4 17.5 0.17 12.2 4.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) MCC-bdg_PDZ PF10506.9 EFC42354.1 - 3.4 7.8 12.7 3.6 7.7 4.2 3.4 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Imm42 PF15593.6 EFC42354.1 - 3.8 8.0 9.2 0.84 10.1 4.5 2.1 2 0 0 2 2 2 0 Immunity protein 42 DUF4407 PF14362.6 EFC42354.1 - 4.4 6.6 7.9 8.4 5.6 7.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4196 PF13846.6 EFC42355.1 - 0.079 13.2 1.6 0.29 11.4 1.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4196) DUF5327 PF17261.2 EFC42355.1 - 1 10.2 13.1 2.4 8.9 5.4 3.7 3 0 0 3 3 3 0 Family of unknown function (DUF5327) HSP20 PF00011.21 EFC42357.1 - 2.7e-24 85.3 1.8 3.6e-24 84.9 1.8 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC42357.1 - 1.7e-06 27.5 0.0 2.6e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA FKBP26_C PF18046.1 EFC42357.1 - 0.02 15.0 0.1 0.71 10.0 0.0 2.3 2 0 0 2 2 2 0 FKBP26_C-terminal CS PF04969.16 EFC42357.1 - 0.023 15.7 1.1 0.15 13.1 1.1 2.0 1 1 0 1 1 1 0 CS domain GPS PF01825.21 EFC42358.1 - 2.5e-08 34.3 2.8 5.8e-08 33.1 2.8 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif RGS PF00615.19 EFC42358.1 - 3.5e-07 30.5 3.0 3.5e-07 30.5 3.0 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain NHL PF01436.21 EFC42358.1 - 2e-05 24.4 0.3 1.6 9.0 0.0 5.1 5 0 0 5 5 5 2 NHL repeat SGL PF08450.12 EFC42358.1 - 0.021 14.4 0.7 0.27 10.8 0.1 3.1 3 1 1 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region LVIVD PF08309.11 EFC42358.1 - 2.1 7.8 6.0 3.9 6.9 0.3 3.6 3 0 0 3 3 3 0 LVIVD repeat ABM PF03992.16 EFC42359.1 - 2.1e-06 27.7 0.1 2.6e-06 27.5 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF1431 PF07248.12 EFC42359.1 - 0.062 13.6 0.6 0.26 11.5 0.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1431) Pkinase PF00069.25 EFC42360.1 - 4.2e-19 68.9 4.1 6.8e-19 68.2 4.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42360.1 - 7.1e-10 38.6 2.1 2.3e-09 37.0 2.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC42360.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC42360.1 - 0.053 12.3 0.1 0.07 11.9 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinesin PF00225.23 EFC42361.1 - 1e-104 350.1 5.6 1e-104 350.1 5.6 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC42361.1 - 1.2e-20 74.0 2.7 1.2e-20 74.0 2.7 3.4 3 1 0 3 3 3 1 Microtubule binding PhoH PF02562.16 EFC42361.1 - 0.0096 15.4 0.0 0.023 14.2 0.0 1.7 1 0 0 1 1 1 1 PhoH-like protein YabA PF06156.13 EFC42361.1 - 0.013 16.1 1.0 0.013 16.1 1.0 3.9 3 1 0 3 3 3 0 Initiation control protein YabA TSC22 PF01166.18 EFC42361.1 - 0.018 15.3 1.5 0.018 15.3 1.5 3.4 3 1 0 3 3 3 0 TSC-22/dip/bun family DUF2205 PF10224.9 EFC42361.1 - 0.029 14.4 0.4 0.029 14.4 0.4 4.5 5 1 0 5 5 5 0 Short coiled-coil protein CK2S PF15011.6 EFC42361.1 - 0.88 9.4 7.7 0.42 10.5 0.2 3.0 3 0 0 3 3 3 0 Casein Kinase 2 substrate Shugoshin_N PF07558.11 EFC42361.1 - 0.88 9.5 10.1 0.42 10.5 6.3 2.6 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.15 EFC42361.1 - 0.9 9.7 14.8 1 9.5 2.5 4.2 2 1 1 3 3 3 0 Basic region leucine zipper Cep57_CLD_2 PF14197.6 EFC42361.1 - 1.1 9.4 9.3 0.94 9.6 2.7 3.3 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Glyco_hydro_108 PF05838.12 EFC42362.1 - 2.3e-11 44.0 0.0 5.8e-11 42.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase 108 SH3_3 PF08239.11 EFC42362.1 - 2.8e-06 27.5 0.4 4.9e-06 26.7 0.4 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain ApoC-I PF04691.12 EFC42362.1 - 0.65 10.0 2.0 18 5.4 0.0 2.7 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) adh_short_C2 PF13561.6 EFC42363.1 - 2.1e-63 214.0 0.0 2.3e-63 213.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC42363.1 - 8.9e-51 172.1 0.1 1.1e-50 171.8 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC42363.1 - 8.1e-06 25.9 0.0 1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 EFC42363.1 - 0.0023 17.9 0.0 0.003 17.5 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Baculo_LEF5 PF04838.12 EFC42363.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 Pyr_redox_2 PF07992.14 EFC42364.1 - 2.3e-33 115.7 0.0 3e-33 115.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC42364.1 - 2.1e-10 41.0 0.2 6.4e-09 36.2 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC42364.1 - 3.8e-07 29.6 0.0 1.4e-06 27.7 0.0 1.9 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 EFC42364.1 - 2.2e-05 23.8 0.0 0.012 14.7 0.0 2.6 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 EFC42364.1 - 0.0049 16.5 0.1 0.026 14.1 0.0 2.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC42364.1 - 0.0088 16.3 0.1 5.4 7.3 0.0 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFC42364.1 - 0.039 13.0 0.0 0.065 12.3 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 EFC42364.1 - 0.09 12.0 0.0 2.1 7.5 0.0 2.7 3 0 0 3 3 3 0 Thi4 family Sacchrp_dh_NADP PF03435.18 EFC42364.1 - 0.11 12.7 0.1 1.2 9.4 0.0 2.5 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain MMR_HSR1 PF01926.23 EFC42365.1 - 5e-09 36.2 0.3 1.2e-08 35.0 0.3 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC42365.1 - 3.9e-06 26.5 0.8 1.3e-05 24.7 0.8 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC42365.1 - 7.9e-05 22.6 2.4 9.2e-05 22.4 0.5 2.0 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EFC42365.1 - 0.00012 21.5 0.9 0.00012 21.5 0.9 2.5 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EFC42365.1 - 0.00023 21.4 0.5 0.0018 18.6 0.0 2.4 1 1 0 2 2 2 1 AAA domain AIG1 PF04548.16 EFC42365.1 - 0.00058 19.2 7.2 0.0021 17.4 7.2 1.9 1 1 0 1 1 1 1 AIG1 family AAA_7 PF12775.7 EFC42365.1 - 0.00075 19.1 2.1 0.00086 18.9 0.2 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_29 PF13555.6 EFC42365.1 - 0.00088 19.0 0.7 0.0021 17.8 0.7 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.6 EFC42365.1 - 0.0011 19.0 0.6 0.018 15.1 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC42365.1 - 0.0024 18.3 0.3 0.0081 16.6 0.0 2.0 3 0 0 3 3 2 1 AAA ATPase domain Arf PF00025.21 EFC42365.1 - 0.0027 17.2 0.2 0.0088 15.5 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 EFC42365.1 - 0.0035 17.6 1.6 0.0086 16.3 0.0 2.4 2 1 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 EFC42365.1 - 0.0049 17.3 0.5 0.027 14.9 0.0 2.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EFC42365.1 - 0.0065 15.9 0.2 0.019 14.4 0.0 2.0 2 0 0 2 2 2 1 Bacterial TniB protein Sigma54_activat PF00158.26 EFC42365.1 - 0.0086 15.8 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain ABC_tran PF00005.27 EFC42365.1 - 0.012 16.2 6.5 0.072 13.6 6.5 2.3 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 EFC42365.1 - 0.014 14.6 1.3 0.022 14.0 0.2 1.9 2 1 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 EFC42365.1 - 0.021 15.2 0.2 0.094 13.1 0.0 2.2 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.9 EFC42365.1 - 0.027 14.2 0.2 0.13 12.0 0.1 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 EFC42365.1 - 0.033 13.8 0.9 0.092 12.3 0.3 2.3 2 1 0 2 2 1 0 Ras family AAA_18 PF13238.6 EFC42365.1 - 0.033 14.7 0.0 0.079 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFC42365.1 - 0.036 13.8 1.5 0.058 13.1 0.2 1.9 2 1 0 2 2 1 0 AAA domain AAA_23 PF13476.6 EFC42365.1 - 0.041 14.4 11.6 0.17 12.3 11.6 2.0 1 1 0 1 1 1 0 AAA domain DUF1871 PF08958.10 EFC42365.1 - 0.049 14.0 3.8 5.3 7.4 0.1 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF1871) AAA_19 PF13245.6 EFC42365.1 - 0.06 13.7 1.3 0.13 12.6 1.3 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFC42365.1 - 0.067 13.3 0.7 0.34 11.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EFC42365.1 - 0.07 13.0 1.7 0.49 10.3 0.5 2.6 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 EFC42365.1 - 0.082 12.9 0.1 0.33 10.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 EFC42365.1 - 0.085 12.5 0.3 0.15 11.7 0.1 1.7 2 1 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Septin PF00735.18 EFC42365.1 - 0.11 11.8 0.1 0.11 11.8 0.1 2.4 3 0 0 3 3 2 0 Septin ATP_bind_1 PF03029.17 EFC42365.1 - 0.13 12.0 4.3 0.5 10.1 0.1 2.6 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EFC42365.1 - 0.25 11.4 4.0 1.1 9.3 4.0 2.2 1 1 0 1 1 1 0 Dynamin family DUF87 PF01935.17 EFC42365.1 - 0.43 10.6 7.6 7.7 6.5 7.6 2.3 1 1 0 1 1 1 0 Helicase HerA, central domain T2SSE PF00437.20 EFC42365.1 - 1.1 8.2 4.2 0.49 9.4 1.2 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF445 PF04286.12 EFC42366.1 - 0.022 14.6 5.1 0.027 14.3 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) ATP11 PF06644.11 EFC42367.1 - 1.2e-41 143.4 0.7 1.3e-41 143.2 0.7 1.0 1 0 0 1 1 1 1 ATP11 protein TFCD_C PF12612.8 EFC42367.1 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal FERM_f0 PF16511.5 EFC42367.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM PCRF PF03462.18 EFC42368.1 - 4.3e-34 118.1 0.0 5.3e-34 117.8 0.0 1.0 1 0 0 1 1 1 1 PCRF domain Phage_TAC_3 PF06896.11 EFC42368.1 - 0.18 12.4 3.0 0.21 12.2 2.1 1.5 2 0 0 2 2 2 0 Phage tail assembly chaperone proteins, TAC Na_H_Exchanger PF00999.21 EFC42370.1 - 5.5e-55 186.7 48.4 5.5e-55 186.7 48.4 1.4 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family TMEM107 PF14995.6 EFC42370.1 - 0.00036 21.0 1.6 0.00036 21.0 1.6 3.3 2 1 1 3 3 3 1 Transmembrane protein DUF2615 PF11027.8 EFC42370.1 - 0.23 11.6 0.7 39 4.5 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) DUF3328 PF11807.8 EFC42370.1 - 0.28 10.9 0.2 1.6 8.5 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3328) Ank_2 PF12796.7 EFC42372.1 - 7.5e-27 93.8 4.9 1.2e-10 41.8 0.1 4.9 3 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC42372.1 - 8.3e-25 86.5 3.2 7.4e-05 23.0 0.1 6.7 4 2 3 7 7 7 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC42372.1 - 1.1e-20 73.7 1.4 5.5e-09 36.4 0.0 5.7 5 0 0 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42372.1 - 1.9e-17 61.5 12.4 0.0062 16.9 0.0 7.8 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 EFC42372.1 - 3.5e-15 55.7 8.5 0.019 15.4 0.0 7.5 8 0 0 8 8 8 5 Ankyrin repeat DUF2520 PF10728.9 EFC42372.1 - 0.11 12.2 0.2 2.8 7.7 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF2520) DUF1479 PF07350.12 EFC42373.1 - 8.1e-11 41.3 0.0 0.00057 18.8 0.0 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 EFC42373.1 - 2.6e-07 31.1 0.0 0.045 14.0 0.0 3.2 3 0 0 3 3 3 2 Phytanoyl-CoA dioxygenase (PhyH) UBA_6 PF18039.1 EFC42373.1 - 0.14 12.1 0.2 0.64 10.0 0.2 2.1 1 1 0 1 1 1 0 UBA-like domain F-box-like PF12937.7 EFC42374.1 - 2.4e-07 30.5 0.6 9.4e-07 28.6 0.0 2.4 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EFC42374.1 - 5.4e-06 26.1 0.1 1.6e-05 24.6 0.1 1.9 1 0 0 1 1 1 1 F-box domain DUF1963 PF09234.10 EFC42374.1 - 0.013 16.0 0.9 0.013 16.0 0.9 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF1963) DUF1496 PF07383.12 EFC42374.1 - 0.1 12.2 1.1 0.21 11.2 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1496) Myb_DNA-binding PF00249.31 EFC42375.1 - 2.5e-33 114.0 9.3 2.9e-16 59.4 1.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC42375.1 - 1.9e-29 101.6 9.5 6.3e-15 55.2 1.7 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFC42375.1 - 9.9e-05 22.3 1.3 0.25 11.4 0.2 3.1 1 1 1 2 2 2 2 SLIDE Rap1_C PF11626.8 EFC42375.1 - 0.002 18.1 0.9 0.14 12.3 0.9 2.8 1 1 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BUD22 PF09073.10 EFC42375.1 - 3 7.1 39.0 0.31 10.3 22.9 2.2 2 0 0 2 2 2 0 BUD22 TFIIF_alpha PF05793.12 EFC42375.1 - 3.1 6.3 41.7 0.82 8.2 24.4 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 EFC42375.1 - 6.1 5.0 25.0 0.43 8.8 12.0 2.3 2 0 0 2 2 2 0 CDC45-like protein XLF PF09302.11 EFC42376.1 - 2.4e-07 31.1 0.4 2.4e-07 31.1 0.4 3.2 3 1 1 4 4 4 2 XLF-Cernunnos, XRcc4-like factor, NHEJ component UPF0158 PF03682.13 EFC42376.1 - 0.038 14.0 0.2 0.038 14.0 0.2 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0158) DUF3381 PF11861.8 EFC42376.1 - 9.6 6.0 23.7 1.3 8.8 6.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3381) DUF2852 PF11014.8 EFC42377.1 - 0.018 15.2 0.7 0.62 10.2 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) SAVED PF18145.1 EFC42377.1 - 0.035 13.9 0.1 0.39 10.5 0.0 2.2 2 0 0 2 2 2 0 SMODS-associated and fused to various effectors sensor domain LON_substr_bdg PF02190.16 EFC42377.1 - 6 6.7 10.0 0.55 10.1 0.8 2.7 2 1 0 3 3 3 0 ATP-dependent protease La (LON) substrate-binding domain RGS PF00615.19 EFC42378.1 - 5e-06 26.8 2.9 3.2e-05 24.2 2.9 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain CLLAC PF15675.5 EFC42378.1 - 0.0097 15.4 3.4 0.025 14.1 3.4 1.7 1 0 0 1 1 1 1 CLLAC-motif containing domain EGF_2 PF07974.13 EFC42379.1 - 3.2e-24 85.0 106.5 5.3e-05 23.5 8.5 7.4 7 0 0 7 7 7 7 EGF-like domain Kelch_5 PF13854.6 EFC42379.1 - 1.8e-07 31.0 8.8 0.34 10.9 0.3 6.0 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EFC42379.1 - 5.4e-05 23.3 13.6 6 7.3 2.5 6.6 5 1 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFC42379.1 - 0.00013 21.5 1.9 0.45 10.1 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 EFC42379.1 - 0.00019 21.6 6.6 2.9 8.3 0.0 6.2 6 1 0 6 6 6 1 Galactose oxidase, central domain EGF PF00008.27 EFC42379.1 - 2.1 8.8 85.6 0.28 11.5 4.5 7.8 7 0 0 7 7 7 0 EGF-like domain zf-C2HC_2 PF13913.6 EFC42380.1 - 1.3e-25 88.7 23.5 9.4e-09 35.0 1.4 4.5 4 0 0 4 4 4 4 zinc-finger of a C2HC-type Rad50_zn_hook PF04423.14 EFC42380.1 - 0.00017 21.3 9.6 0.64 9.9 0.3 4.8 4 1 0 4 4 4 2 Rad50 zinc hook motif Sgf11 PF08209.11 EFC42380.1 - 0.0005 19.6 7.8 0.033 13.7 0.5 2.7 2 0 0 2 2 2 2 Sgf11 (transcriptional regulation protein) TRAF6_Z2 PF18048.1 EFC42380.1 - 0.058 13.5 0.1 0.058 13.5 0.1 3.5 4 0 0 4 4 4 0 TNF receptor-associated factor 6 zinc finger 2 zf-RING_7 PF02591.15 EFC42380.1 - 0.065 13.4 3.1 3.1 8.0 0.1 3.3 3 0 0 3 3 3 0 C4-type zinc ribbon domain c-SKI_SMAD_bind PF08782.10 EFC42380.1 - 0.069 13.4 0.6 0.069 13.4 0.6 4.0 3 1 1 4 4 4 0 c-SKI Smad4 binding domain NinF PF05810.12 EFC42380.1 - 0.088 12.7 4.1 3 7.8 0.1 3.1 3 0 0 3 3 3 0 NinF protein zf-ribbon_3 PF13248.6 EFC42380.1 - 0.15 11.5 10.3 4.4 6.9 0.2 4.5 4 0 0 4 4 4 0 zinc-ribbon domain CxC7 PF18866.1 EFC42380.1 - 0.2 11.9 4.7 1.7 8.8 0.1 3.2 3 1 0 3 3 3 0 CxC7 like cysteine cluster associated with KDZ transposases zf-Di19 PF05605.12 EFC42380.1 - 0.22 11.8 17.1 1 9.7 2.4 4.2 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Vps39_2 PF10367.9 EFC42380.1 - 0.33 11.4 6.6 1.4 9.4 0.1 3.1 4 0 0 4 4 3 0 Vacuolar sorting protein 39 domain 2 IQ PF00612.27 EFC42380.1 - 0.39 10.6 1.3 30 4.8 0.1 2.4 2 0 0 2 2 2 0 IQ calmodulin-binding motif zinc_ribbon_9 PF14369.6 EFC42380.1 - 0.83 10.0 9.3 17 5.8 0.0 4.4 4 0 0 4 4 4 0 zinc-ribbon DUF1360 PF07098.11 EFC42380.1 - 2.2 8.3 3.5 11 6.1 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1360) zf-C2H2_3rep PF18868.1 EFC42380.1 - 2.7 8.7 12.7 2.5 8.8 0.2 3.6 3 1 0 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 EFC42380.1 - 6.7 7.8 24.0 1.4 9.9 3.1 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFC42380.1 - 7.2 7.3 14.8 17 6.1 2.4 3.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type SURF1 PF02104.15 EFC42381.1 - 5.1e-30 105.0 0.0 8.8e-30 104.2 0.0 1.4 1 0 0 1 1 1 1 SURF1 family Glyco_hydro_65m PF03632.15 EFC42382.1 - 2.1e-53 181.6 0.1 1.3e-45 156.0 0.0 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain DUF2152 PF10222.9 EFC42382.1 - 7.4e-18 64.2 0.2 3.7e-17 61.9 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2152) Glyco_hydro_65N PF03636.15 EFC42382.1 - 0.00053 19.7 0.2 0.0011 18.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Choline_kinase PF01633.20 EFC42383.1 - 1.8e-41 142.0 0.7 5.4e-41 140.5 0.7 1.9 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFC42383.1 - 3.9e-08 33.5 0.0 5.8e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RhoGAP PF00620.27 EFC42384.1 - 1.2e-26 93.4 0.4 2.5e-26 92.3 0.4 1.6 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 EFC42384.1 - 2.6e-11 43.5 0.0 4.7e-11 42.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PapD-like PF14874.6 EFC42384.1 - 0.0017 18.5 0.0 0.0044 17.1 0.0 1.7 1 0 0 1 1 1 1 Flagellar-associated PapD-like Esterase_phd PF10503.9 EFC42385.1 - 7e-08 32.2 2.4 0.00063 19.3 0.1 2.2 2 0 0 2 2 2 2 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EFC42385.1 - 0.00098 18.7 0.2 0.0032 17.0 0.2 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EFC42385.1 - 0.023 14.5 0.5 0.047 13.5 0.1 1.7 2 1 0 2 2 2 0 alpha/beta hydrolase fold RCC_reductase PF06405.11 EFC42386.1 - 0.032 13.4 0.1 0.05 12.8 0.1 1.2 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) Oxidored_q2 PF00420.24 EFC42386.1 - 0.14 11.8 1.9 0.23 11.1 0.2 1.9 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L SelK_SelG PF10961.8 EFC42387.1 - 0.25 12.0 4.3 0.8 10.4 3.1 2.5 2 0 0 2 2 2 0 Selenoprotein SelK_SelG LRR_6 PF13516.6 EFC42388.1 - 2.3e-31 105.1 25.9 0.00022 21.0 0.1 9.9 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC42388.1 - 7.3e-21 73.9 28.0 0.00087 19.6 0.3 6.3 3 1 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC42388.1 - 1.2e-20 73.0 23.8 6.8e-07 29.0 2.7 4.8 2 1 4 6 6 6 6 Leucine rich repeat LRR_1 PF00560.33 EFC42388.1 - 7e-09 35.0 19.5 18 6.4 0.0 9.7 8 2 0 8 8 8 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC42388.1 - 9.1e-06 25.3 7.0 1.1 8.8 0.1 3.8 1 1 3 4 4 4 3 Leucine-rich repeat Spc24 PF08286.11 EFC42388.1 - 0.15 12.3 1.8 0.23 11.7 0.2 2.1 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Sel1 PF08238.12 EFC42389.1 - 4.4e-15 55.8 28.9 0.00087 19.9 0.1 7.9 8 0 0 8 8 8 6 Sel1 repeat F-box PF00646.33 EFC42389.1 - 0.00021 21.1 0.1 0.00068 19.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain TPR_6 PF13174.6 EFC42389.1 - 0.00035 21.0 7.9 0.18 12.5 0.1 6.2 6 1 0 6 6 6 1 Tetratricopeptide repeat DUF5583 PF17821.1 EFC42389.1 - 0.089 12.7 0.3 0.24 11.3 0.3 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5583) TPR_2 PF07719.17 EFC42389.1 - 0.13 12.5 0.1 0.13 12.5 0.1 7.5 8 2 1 9 9 9 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42389.1 - 3.8 7.8 0.0 3.8 7.8 0.0 5.6 9 1 1 10 10 10 0 Tetratricopeptide repeat MIR PF02815.19 EFC42390.1 - 8.2e-23 81.2 0.3 3.8e-11 43.2 0.0 3.0 1 1 2 3 3 3 3 MIR domain Mucin_bdg PF03272.13 EFC42390.1 - 0.0032 17.5 0.4 2 8.5 0.0 2.8 1 1 2 3 3 3 2 Putative mucin or carbohydrate-binding module Methyltransf_11 PF08241.12 EFC42392.1 - 1.1e-10 42.1 0.0 2.8e-10 40.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC42392.1 - 6.7e-10 39.6 0.1 5.4e-09 36.6 0.0 2.4 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC42392.1 - 4.1e-08 33.1 0.0 7.3e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC42392.1 - 2.7e-06 28.0 0.4 0.0002 22.0 0.0 3.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFC42392.1 - 0.012 15.1 0.1 0.14 11.7 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase small domain TPMT PF05724.11 EFC42392.1 - 0.074 12.7 0.1 0.44 10.2 0.1 2.1 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) GDPD PF03009.17 EFC42393.1 - 0.046 13.5 0.6 0.13 11.9 0.2 1.8 1 1 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family HlyC PF02794.16 EFC42394.1 - 0.057 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 RTX toxin acyltransferase family CAP PF00188.26 EFC42395.1 - 3.9e-43 147.3 6.5 5.5e-22 78.9 0.9 2.5 2 1 0 2 2 2 2 Cysteine-rich secretory protein family Metallothio_Euk PF12749.7 EFC42395.1 - 0.093 12.9 5.3 1.3 9.2 0.2 2.3 2 0 0 2 2 2 0 Eukaryotic metallothionein DUF4656 PF15551.6 EFC42395.1 - 0.19 11.2 7.6 0.083 12.4 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4656) DCA16 PF15349.6 EFC42395.1 - 1.7 8.2 6.5 7.8 6.0 1.0 2.5 2 0 0 2 2 2 0 DDB1- and CUL4-associated factor 16 RtcB PF01139.17 EFC42397.1 - 2.2e-127 425.7 0.3 2.7e-127 425.4 0.3 1.1 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB DUF4514 PF14986.6 EFC42397.1 - 0.09 12.8 0.3 0.21 11.6 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4514) 3HCDH_N PF02737.18 EFC42399.1 - 0.058 13.3 0.5 0.67 9.8 0.0 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ank_5 PF13857.6 EFC42399.1 - 0.19 12.1 0.0 0.54 10.6 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) UpxZ PF06603.11 EFC42400.1 - 0.072 13.4 0.3 0.65 10.3 0.1 2.7 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists AAA_11 PF13086.6 EFC42401.1 - 2.7 7.7 7.3 0.24 11.1 1.6 2.2 2 1 0 2 2 2 0 AAA domain LRR_6 PF13516.6 EFC42402.1 - 3.2e-45 148.3 21.9 0.00023 21.0 0.0 13.9 14 0 0 14 14 14 10 Leucine Rich repeat LRR_8 PF13855.6 EFC42402.1 - 2.1e-32 110.7 36.1 9.8e-10 38.1 1.1 5.7 3 2 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC42402.1 - 8.3e-26 89.6 35.8 6.3e-05 23.3 0.6 9.0 3 2 7 11 11 11 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42402.1 - 1.1e-14 52.7 15.0 1.4 9.7 0.0 11.6 11 1 1 12 12 12 2 Leucine Rich Repeat LRR_5 PF13306.6 EFC42402.1 - 2.4e-09 37.2 12.9 0.0012 18.9 6.7 3.3 2 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 EFC42402.1 - 2.6e-08 33.6 4.2 0.0025 17.3 0.4 3.6 1 1 2 3 3 3 3 Leucine-rich repeat F-box-like PF12937.7 EFC42402.1 - 1.6e-05 24.7 0.3 3.1e-05 23.8 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC42402.1 - 0.0011 18.8 0.8 0.0025 17.7 0.8 1.6 1 0 0 1 1 1 1 F-box domain CLU_N PF15044.6 EFC42402.1 - 0.069 13.5 11.6 6.9 7.1 0.1 5.8 3 2 4 7 7 7 0 Mitochondrial function, CLU-N-term NKWYS PF10364.9 EFC42402.1 - 0.13 12.4 6.5 0.2 11.7 0.4 2.9 3 0 0 3 3 3 0 Putative capsular polysaccharide synthesis protein Peptidase_M3 PF01432.20 EFC42404.1 - 4.5e-25 88.8 0.2 1.2e-24 87.5 0.2 1.7 1 1 0 1 1 1 1 Peptidase family M3 PAS_9 PF13426.7 EFC42404.1 - 0.021 15.1 0.1 0.62 10.4 0.0 3.1 3 0 0 3 3 3 0 PAS domain Post_transc_reg PF13797.6 EFC42404.1 - 0.032 14.1 0.2 0.091 12.6 0.2 1.8 1 0 0 1 1 1 0 Post-transcriptional regulator SpoVT_C PF15714.5 EFC42404.1 - 4.2 7.4 5.7 9.8 6.2 2.5 2.9 3 0 0 3 3 3 0 Stage V sporulation protein T C-terminal, transcription factor SEP PF08059.13 EFC42405.1 - 1.7e-14 54.1 0.0 5.6e-14 52.5 0.0 1.9 1 0 0 1 1 1 1 SEP domain MSA-2c PF12238.8 EFC42405.1 - 0.0028 17.7 1.6 0.0028 17.7 1.6 1.9 2 0 0 2 2 2 1 Merozoite surface antigen 2c EDR1 PF14381.6 EFC42405.1 - 0.0094 15.7 0.2 0.022 14.5 0.2 1.7 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Syntaxin-6_N PF09177.11 EFC42405.1 - 0.082 13.5 1.0 0.26 11.9 0.3 2.2 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF16 PF01519.16 EFC42405.1 - 9.6 6.8 11.0 0.43 11.1 1.7 2.9 3 0 0 3 3 3 0 Protein of unknown function DUF16 Metallophos PF00149.28 EFC42408.1 - 4.2e-30 105.8 0.4 7.3e-30 105.0 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 EFC42408.1 - 9.2e-05 22.8 0.6 0.00021 21.7 0.6 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain DUF4419 PF14388.6 EFC42409.1 - 0.0076 15.7 0.1 0.012 15.0 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Vpu PF00558.19 EFC42409.1 - 0.1 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Vpu protein HATPase_c PF02518.26 EFC42410.1 - 2.7e-22 79.4 0.2 7.1e-22 78.0 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_2 PF13185.6 EFC42410.1 - 2.7e-19 69.8 0.0 5.8e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 GAF domain Response_reg PF00072.24 EFC42410.1 - 2.5e-18 66.3 0.2 7.3e-18 64.8 0.2 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC42410.1 - 1.1e-11 44.6 0.1 1.1e-11 44.6 0.1 3.3 4 0 0 4 4 4 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 EFC42410.1 - 3.6e-06 27.7 0.0 7.4e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 GAF domain HATPase_c_3 PF13589.6 EFC42410.1 - 0.015 15.1 0.1 0.045 13.6 0.1 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1151 PF06625.11 EFC42411.1 - 0.46 10.4 10.8 0.067 13.1 4.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) Zn_clus PF00172.18 EFC42412.1 - 2.8e-08 33.7 9.7 4.7e-08 33.0 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain G6PD_N PF00479.22 EFC42412.1 - 0.084 13.5 0.0 0.19 12.4 0.0 1.6 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain PBP1_TM PF14812.6 EFC42412.1 - 5.7 7.4 13.9 0.79 10.1 6.0 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ras PF00071.22 EFC42413.1 - 2.1e-20 73.0 0.0 4.6e-20 71.8 0.0 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC42413.1 - 3.6e-18 65.9 0.0 1.1e-17 64.4 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC42413.1 - 0.019 14.8 0.6 0.041 13.8 0.6 1.5 1 0 0 1 1 1 0 F-box-like ADH_zinc_N PF00107.26 EFC42414.1 - 1.3e-24 86.6 0.0 2.1e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC42414.1 - 3.5e-16 60.5 0.0 3e-15 57.5 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC42414.1 - 1.3e-08 34.7 0.0 3e-08 33.5 0.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF1899 PF08953.11 EFC42415.1 - 3.6e-21 74.8 0.0 7.1e-21 73.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 EFC42415.1 - 6.7e-19 67.5 0.1 1.3e-18 66.5 0.1 1.6 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 EFC42415.1 - 4.6e-17 62.1 0.1 9.5e-05 23.1 0.0 4.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42415.1 - 1.6e-06 28.3 0.0 0.031 14.6 0.0 4.2 3 1 2 5 5 4 1 Anaphase-promoting complex subunit 4 WD40 domain JAKMIP_CC3 PF16034.5 EFC42415.1 - 0.011 15.6 3.3 0.019 15.0 3.3 1.3 1 0 0 1 1 1 0 JAKMIP CC3 domain PQQ_2 PF13360.6 EFC42415.1 - 0.015 14.8 0.2 0.029 14.0 0.2 1.4 1 0 0 1 1 1 0 PQQ-like domain bZIP_1 PF00170.21 EFC42415.1 - 0.029 14.5 3.9 0.053 13.6 3.9 1.4 1 0 0 1 1 1 0 bZIP transcription factor Nup160 PF11715.8 EFC42415.1 - 0.059 12.0 0.0 0.26 9.9 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Cnn_1N PF07989.11 EFC42415.1 - 0.21 11.8 5.4 0.13 12.4 3.5 1.7 2 0 0 2 2 1 0 Centrosomin N-terminal motif 1 bZIP_2 PF07716.15 EFC42415.1 - 0.4 10.8 4.9 0.78 9.9 4.9 1.5 1 0 0 1 1 1 0 Basic region leucine zipper APC_N_CC PF16689.5 EFC42415.1 - 0.53 10.4 5.9 0.34 11.0 3.9 1.8 2 1 0 2 2 1 0 Coiled-coil N-terminus of APC, dimerisation domain HALZ PF02183.18 EFC42415.1 - 0.72 10.1 3.7 1.2 9.4 3.7 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper HEAT PF02985.22 EFC42416.1 - 0.0019 18.3 0.3 25 5.5 0.0 4.2 3 0 0 3 3 3 1 HEAT repeat NOA36 PF06524.12 EFC42416.1 - 0.37 10.1 3.2 0.67 9.2 3.2 1.3 1 0 0 1 1 1 0 NOA36 protein PdaC PF13739.6 EFC42416.1 - 1.1 10.3 3.7 1.2 10.1 0.4 2.9 2 0 0 2 2 2 0 Deacetylase PdaC DUF4611 PF15387.6 EFC42416.1 - 8.7 6.6 7.4 57 4.0 7.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Metallophos PF00149.28 EFC42417.1 - 3.3e-15 57.1 1.0 4.6e-15 56.7 1.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DDE_Tnp_1_4 PF13701.6 EFC42417.1 - 0.2 9.9 0.0 0.26 9.5 0.0 1.1 1 0 0 1 1 1 0 Transposase DDE domain group 1 Thioredoxin PF00085.20 EFC42418.1 - 4.7e-32 110.0 0.0 3.1e-26 91.4 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_2 PF13098.6 EFC42418.1 - 5e-09 36.6 0.1 0.00011 22.6 0.0 3.0 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 EFC42418.1 - 2.1e-08 33.8 0.0 9.6e-06 25.1 0.0 2.3 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFC42418.1 - 0.0014 18.9 0.0 0.46 10.8 0.0 3.1 3 1 1 4 4 4 1 Thioredoxin-like HyaE PF07449.11 EFC42418.1 - 0.0032 17.4 0.0 0.43 10.6 0.0 2.9 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_4 PF13462.6 EFC42418.1 - 0.024 14.8 0.1 2.4 8.3 0.1 2.5 1 1 0 1 1 1 0 Thioredoxin DUF2673 PF10880.8 EFC42418.1 - 0.091 12.9 0.1 0.22 11.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) Thioredoxin_7 PF13899.6 EFC42418.1 - 0.12 12.5 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like His_Phos_2 PF00328.22 EFC42420.1 - 3.1e-17 63.0 0.0 6.5e-17 61.9 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Guanylate_cyc PF00211.20 EFC42421.1 - 6.9e-05 22.5 0.0 0.00019 21.1 0.0 1.8 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain UvrD-helicase PF00580.21 EFC42421.1 - 0.038 13.5 1.4 0.041 13.4 0.1 1.6 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF4246 PF14033.6 EFC42422.1 - 3.2e-78 263.9 4.4 8.6e-46 157.0 0.0 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) Ca_bind_SSO6904 PF18249.1 EFC42422.1 - 0.04 14.3 0.1 0.46 10.9 0.1 2.5 2 0 0 2 2 2 0 Calcium binding protein SSO6904 YnfE PF17452.2 EFC42422.1 - 0.16 12.3 2.6 0.16 12.2 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized YnfE-like EF-hand_7 PF13499.6 EFC42424.1 - 0.0009 19.6 1.6 1.8 9.1 0.5 3.7 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 EFC42424.1 - 0.0094 15.8 1.0 1.9 8.4 0.0 3.7 4 0 0 4 4 4 1 EF-hand domain pair GEMIN8 PF15348.6 EFC42424.1 - 7.9 6.7 10.8 0.51 10.6 4.3 1.9 1 1 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 MTP18 PF10558.9 EFC42425.1 - 6.9e-49 166.1 8.7 8.2e-29 100.8 0.3 2.1 1 1 1 2 2 2 2 Mitochondrial 18 KDa protein (MTP18) DUF4064 PF13273.6 EFC42426.1 - 0.0072 16.6 2.7 0.0072 16.6 2.7 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF4064) Tetraspanin PF00335.20 EFC42426.1 - 0.025 14.3 7.2 0.23 11.1 1.6 2.3 2 0 0 2 2 2 0 Tetraspanin family DHHC PF01529.20 EFC42426.1 - 0.3 11.2 11.1 0.35 11.0 5.8 2.5 2 0 0 2 2 2 0 DHHC palmitoyltransferase Sigma_reg_N PF13800.6 EFC42426.1 - 0.56 10.5 11.2 3.6 7.9 0.7 4.1 3 1 1 4 4 4 0 Sigma factor regulator N-terminal RhoGAP PF00620.27 EFC42427.1 - 1.4e-32 112.6 0.8 4.1e-32 111.1 0.1 2.0 2 0 0 2 2 2 1 RhoGAP domain MyTH4 PF00784.17 EFC42427.1 - 2.7e-20 72.9 0.8 6.2e-20 71.7 0.1 2.0 2 0 0 2 2 2 1 MyTH4 domain WW PF00397.26 EFC42427.1 - 2.4e-18 65.9 12.6 1.4e-10 41.1 1.1 2.5 2 0 0 2 2 2 2 WW domain DLP_helical PF18709.1 EFC42428.1 - 0.012 14.9 3.6 0.35 10.0 1.5 2.1 2 0 0 2 2 2 0 Dynamin-like helical domain CRISPR_assoc PF08798.11 EFC42428.1 - 0.024 14.7 0.1 0.033 14.3 0.1 1.3 1 0 0 1 1 1 0 CRISPR associated protein WH2 PF02205.20 EFC42428.1 - 0.045 13.6 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 WH2 motif I_LWEQ PF01608.17 EFC42428.1 - 0.12 12.6 2.0 0.2 11.9 2.0 1.3 1 0 0 1 1 1 0 I/LWEQ domain KELK PF15796.5 EFC42428.1 - 0.56 10.7 9.4 1.5 9.4 9.5 1.7 1 1 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase p450 PF00067.22 EFC42429.1 - 6.6e-59 199.9 1.7 8.3e-59 199.5 1.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 HNH_repeat PF18780.1 EFC42429.1 - 0.035 13.9 1.4 0.079 12.8 0.3 2.2 2 0 0 2 2 2 0 Homing endonuclease repeat PC4 PF02229.16 EFC42429.1 - 0.051 13.2 0.3 0.26 10.9 0.0 2.2 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) FAD_binding_7 PF03441.14 EFC42429.1 - 0.17 11.3 0.4 3.5 7.1 0.0 2.8 3 0 0 3 3 3 0 FAD binding domain of DNA photolyase DUF2781 PF10914.8 EFC42430.1 - 2.4e-22 79.9 6.6 2.4e-22 79.9 6.6 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2781) Tim54 PF11711.8 EFC42430.1 - 0.11 11.3 1.9 0.34 9.7 0.0 2.0 1 1 1 2 2 2 0 Inner membrane protein import complex subunit Tim54 RCC1_2 PF13540.6 EFC42431.1 - 2.4e-28 97.3 22.3 0.00031 20.5 0.0 10.1 9 0 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC42431.1 - 1.9e-17 63.6 15.3 0.16 12.6 0.0 9.8 10 0 0 10 10 10 7 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC42431.1 - 9.8e-08 32.2 62.6 4.5e-05 23.7 4.2 4.6 5 0 0 5 5 5 3 EGF-like domain EGF PF00008.27 EFC42431.1 - 0.0073 16.6 2.9 0.0073 16.6 2.9 4.6 4 0 0 4 4 4 1 EGF-like domain CSN8_PSD8_EIF3K PF10075.9 EFC42432.1 - 2e-26 92.7 0.7 2e-26 92.7 0.7 1.8 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 EFC42432.1 - 7.2e-06 25.6 1.5 1.1e-05 25.0 1.5 1.3 1 0 0 1 1 1 1 SAC3/GANP family PCI PF01399.27 EFC42432.1 - 0.0027 18.2 3.8 0.92 10.0 3.8 3.2 1 1 0 1 1 1 1 PCI domain DUF61 PF01886.16 EFC42432.1 - 0.032 14.3 1.1 0.062 13.4 0.4 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF61 BTB PF00651.31 EFC42433.1 - 1.4e-18 67.1 0.5 3.5e-18 65.8 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain SPRY PF00622.28 EFC42433.1 - 4.6e-07 30.0 0.4 6.9e-07 29.4 0.4 1.3 1 0 0 1 1 1 1 SPRY domain Complex1_LYR PF05347.15 EFC42433.1 - 4.3e-06 26.7 0.1 8.7e-06 25.7 0.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF4116 PF13475.6 EFC42434.1 - 0.019 14.7 0.6 0.11 12.2 0.6 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4116) SMAP PF15477.6 EFC42434.1 - 0.1 13.6 0.1 0.22 12.5 0.1 1.5 1 0 0 1 1 1 0 Small acidic protein family LRR_6 PF13516.6 EFC42435.1 - 6.4e-31 103.8 27.9 1.3e-05 24.9 0.0 10.4 11 0 0 11 11 11 8 Leucine Rich repeat LRR_8 PF13855.6 EFC42435.1 - 1.5e-28 98.4 17.0 2.2e-08 33.7 2.5 5.7 4 2 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC42435.1 - 7.7e-22 77.0 23.8 0.0015 18.9 4.8 8.3 2 1 6 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42435.1 - 7.9e-12 44.0 14.9 5.8 7.9 0.0 10.4 12 0 0 12 12 12 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC42435.1 - 3.9e-05 23.2 4.8 0.15 11.6 2.3 3.3 2 1 1 3 3 3 3 Leucine-rich repeat ApoB100_C PF12491.8 EFC42435.1 - 0.0019 18.1 2.3 0.016 15.2 0.0 3.6 2 2 2 5 5 5 1 Apolipoprotein B100 C terminal Beta_helix PF13229.6 EFC42435.1 - 0.011 15.6 6.6 2.7 7.8 0.0 2.8 2 1 0 2 2 2 0 Right handed beta helix region CSN8_PSD8_EIF3K PF10075.9 EFC42435.1 - 0.075 13.0 0.0 0.28 11.1 0.0 2.0 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family RGS PF00615.19 EFC42436.1 - 2.1e-09 37.7 1.6 5.5e-09 36.3 1.6 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Phage_lambda_P PF06992.11 EFC42436.1 - 0.072 12.8 0.5 0.27 11.0 0.5 1.9 1 0 0 1 1 1 0 Replication protein P DUF4116 PF13475.6 EFC42437.1 - 2.7e-73 241.5 46.7 3.1e-10 39.6 0.1 11.4 4 2 10 14 14 14 14 Domain of unknown function (DUF4116) GSHPx PF00255.19 EFC42438.1 - 7.8e-36 121.9 0.5 9.6e-36 121.7 0.5 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EFC42438.1 - 0.00045 20.1 0.1 0.0016 18.3 0.1 2.0 1 1 0 1 1 1 1 AhpC/TSA family Par3_HAL_N_term PF12053.8 EFC42439.1 - 0.02 15.1 0.9 0.15 12.2 0.0 2.5 2 1 1 3 3 3 0 N-terminal of Par3 and HAL proteins MBT PF02820.18 EFC42439.1 - 0.095 13.1 0.3 14 6.1 0.0 2.6 2 0 0 2 2 2 0 mbt repeat PhyH PF05721.13 EFC42440.1 - 0.0001 22.7 0.1 0.00025 21.4 0.0 1.7 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) DDHD PF02862.17 EFC42441.1 - 4.4e-23 82.6 1.4 4e-17 63.1 0.5 2.5 1 1 1 2 2 2 2 DDHD domain PGAP1 PF07819.13 EFC42441.1 - 0.0053 16.5 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 EFC42441.1 - 0.006 16.1 0.0 0.035 13.6 0.0 2.1 2 0 0 2 2 2 1 Putative serine esterase (DUF676) SLM4 PF16818.5 EFC42441.1 - 0.015 15.2 0.2 0.024 14.6 0.2 1.5 1 1 0 1 1 1 0 Protein SLM4 Thioesterase PF00975.20 EFC42441.1 - 0.018 15.1 0.0 0.027 14.6 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 EFC42441.1 - 0.053 13.4 0.1 0.17 11.8 0.0 1.9 2 1 0 2 2 2 0 Lipase (class 3) Hydrolase_4 PF12146.8 EFC42441.1 - 0.13 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF900 PF05990.12 EFC42441.1 - 0.14 11.6 0.0 0.32 10.5 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_6 PF12697.7 EFC42441.1 - 0.15 12.6 0.0 0.21 12.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Na_Ca_ex PF01699.24 EFC42442.1 - 7.8e-21 74.6 34.9 3.7e-10 40.0 16.8 2.7 2 1 0 2 2 2 2 Sodium/calcium exchanger protein EphA2_TM PF14575.6 EFC42442.1 - 0.03 15.2 0.0 0.48 11.3 0.3 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Saf_2TM PF18303.1 EFC42442.1 - 0.068 12.8 0.2 0.25 10.9 0.1 2.1 1 1 0 1 1 1 0 SAVED-fused 2TM effector domain DUF4064 PF13273.6 EFC42442.1 - 1.8 8.9 20.6 1.3 9.3 0.2 4.7 2 1 2 4 4 4 0 Protein of unknown function (DUF4064) RseA_C PF03873.13 EFC42442.1 - 8 6.8 7.0 0.8 10.0 2.2 1.8 2 0 0 2 2 2 0 Anti sigma-E protein RseA, C-terminal domain Urocanase_N PF17391.2 EFC42443.1 - 0.051 13.3 0.0 0.081 12.6 0.0 1.3 1 0 0 1 1 1 0 Urocanase N-terminal domain SAM_decarbox PF01536.16 EFC42444.1 - 6.8e-106 354.3 0.6 1.1e-105 353.5 0.6 1.3 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase AdoMet_dc PF02675.15 EFC42444.1 - 0.0019 18.4 0.0 0.017 15.4 0.0 2.4 2 0 0 2 2 2 1 S-adenosylmethionine decarboxylase DUF572 PF04502.13 EFC42445.1 - 8e-38 130.9 23.8 9.8e-38 130.6 23.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Zn_ribbon_SprT PF17283.2 EFC42445.1 - 0.0063 16.4 1.2 0.0063 16.4 1.2 1.9 2 0 0 2 2 2 1 SprT-like zinc ribbon domain Nudix_N_2 PF14803.6 EFC42445.1 - 0.047 13.6 3.0 0.047 13.6 3.0 2.4 2 0 0 2 2 2 0 Nudix N-terminal HalOD2 PF18547.1 EFC42445.1 - 0.15 12.0 0.2 3.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Halobacterial output domain 2 zf-ACC PF17848.1 EFC42445.1 - 0.18 11.9 3.6 1.1 9.4 0.4 2.7 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PIG-S PF10510.9 EFC42447.1 - 2.7e-101 339.9 5.0 3.1e-101 339.7 5.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein POTRA_TamA_1 PF17243.2 EFC42447.1 - 0.12 12.5 0.1 0.33 11.1 0.1 1.7 1 0 0 1 1 1 0 POTRA domain TamA domain 1 DUF2012 PF09430.10 EFC42448.1 - 3.1e-15 56.4 0.0 4.8e-15 55.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) EMC3_TMCO1 PF01956.16 EFC42448.1 - 0.025 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like CarboxypepD_reg PF13620.6 EFC42448.1 - 0.11 12.7 0.0 0.29 11.4 0.0 1.7 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain Trypan_PARP PF05887.11 EFC42449.1 - 1.7 8.6 13.2 5.9 6.9 0.1 2.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) FHA PF00498.26 EFC42451.1 - 1.2e-14 54.4 1.7 1.8e-14 53.8 0.1 2.2 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 EFC42451.1 - 3e-07 30.6 0.0 8.7e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Rootletin PF15035.6 EFC42451.1 - 0.00069 19.7 8.4 0.00069 19.7 8.4 2.0 2 1 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion COG2 PF06148.11 EFC42451.1 - 0.008 16.3 5.8 0.6 10.2 0.9 3.9 3 1 1 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 TPR_MLP1_2 PF07926.12 EFC42451.1 - 2.8 8.0 15.9 0.057 13.5 1.5 3.3 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Tubulin PF00091.25 EFC42452.1 - 7.6e-67 225.3 0.0 1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC42452.1 - 1.5e-50 170.6 0.1 2.5e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC42452.1 - 0.0023 17.7 0.0 0.0059 16.3 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 EFC42452.1 - 0.18 10.9 0.1 0.29 10.3 0.1 1.3 1 0 0 1 1 1 0 Tubulin like RGS PF00615.19 EFC42453.1 - 1.5e-05 25.2 6.5 7.5e-05 23.0 6.0 2.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain SAM_1 PF00536.30 EFC42453.1 - 8.7e-05 22.9 2.8 0.00017 22.0 0.1 2.6 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC42453.1 - 0.031 14.4 0.1 0.072 13.2 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Form_Nir_trans PF01226.17 EFC42454.1 - 1e-69 234.5 23.2 1.3e-69 234.1 23.2 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Ost5 PF05251.12 EFC42454.1 - 0.044 14.0 2.9 3.4 8.0 0.2 3.3 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 TatD_DNase PF01026.21 EFC42455.1 - 3.6e-46 157.6 0.1 4e-46 157.5 0.1 1.0 1 0 0 1 1 1 1 TatD related DNase Herpes_IE2_3 PF03361.14 EFC42455.1 - 0.0012 18.7 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 Herpes virus intermediate/early protein 2/3 RecG_N PF17190.4 EFC42455.1 - 0.048 14.4 1.7 5.5 7.8 0.1 3.4 2 2 1 3 3 3 0 RecG N-terminal helical domain B12-binding PF02310.19 EFC42455.1 - 0.14 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 B12 binding domain Sel1 PF08238.12 EFC42457.1 - 2.3e-24 85.3 5.5 6.5e-07 29.8 0.0 4.6 4 0 0 4 4 4 4 Sel1 repeat WD40 PF00400.32 EFC42457.1 - 4.7e-10 39.9 4.1 0.17 12.8 0.0 6.6 6 1 1 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42457.1 - 1.5e-05 25.2 0.0 12 6.3 0.0 5.2 3 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain CXCXC PF03128.14 EFC42457.1 - 0.015 15.7 0.6 0.063 13.7 0.6 2.2 1 0 0 1 1 1 0 CXCXC repeat Rep_fac-A_C PF08646.10 EFC42457.1 - 0.055 13.2 1.2 0.25 11.1 0.1 2.7 2 1 0 2 2 2 0 Replication factor-A C terminal domain DUF898 PF05987.13 EFC42458.1 - 0.12 11.4 4.2 0.48 9.4 2.0 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF898) BRCT_2 PF16589.5 EFC42459.1 - 1.4e-10 41.4 0.0 3.2e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFC42459.1 - 3.5e-07 30.5 0.1 1.2e-06 28.8 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 EFC42459.1 - 6.6e-05 23.1 0.0 0.00015 22.0 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 EFC42459.1 - 0.1 12.5 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 twin BRCT domain DSHCT PF08148.12 EFC42460.1 - 1.5e-49 167.9 0.6 4.7e-49 166.2 0.6 1.9 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 EFC42460.1 - 6.6e-17 61.8 1.3 1.7e-16 60.5 0.0 2.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 EFC42460.1 - 1.3e-15 58.1 9.3 2.1e-09 37.7 4.1 2.7 2 1 1 3 3 3 2 rRNA-processing arch domain ResIII PF04851.15 EFC42460.1 - 9.7e-07 28.9 0.3 3.9e-06 27.0 0.1 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC42460.1 - 1.8e-06 28.2 0.0 1e-05 25.8 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ATPase_2 PF01637.18 EFC42460.1 - 0.032 14.1 0.5 0.12 12.3 0.1 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PhoH PF02562.16 EFC42460.1 - 0.055 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ANAPC4_WD40 PF12894.7 EFC42462.1 - 0.0014 18.9 0.0 0.032 14.5 0.0 3.0 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC42462.1 - 0.87 10.6 3.8 8 7.5 0.1 4.0 5 1 0 5 5 5 0 WD domain, G-beta repeat UPF0669 PF17065.5 EFC42464.1 - 4.1e-15 56.0 10.0 4.4e-06 26.6 0.0 6.4 5 2 1 7 7 7 5 Putative cytokine, C6ORF120 ATG27 PF09451.10 EFC42464.1 - 1.6e-05 24.9 0.0 3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 27 Uricase PF01014.18 EFC42465.1 - 3.4e-09 37.1 0.4 8.6e-09 35.7 0.1 1.9 3 0 0 3 3 3 1 Uricase WSN PF02206.18 EFC42465.1 - 0.0067 16.3 0.6 0.25 11.3 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function DUF3194 PF11419.8 EFC42465.1 - 0.2 12.0 2.6 0.91 9.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3194) CBS PF00571.28 EFC42466.1 - 6e-17 61.8 0.1 2.6e-10 40.6 0.0 2.1 2 0 0 2 2 2 2 CBS domain Cyt-b5 PF00173.28 EFC42467.1 - 5.8e-08 32.8 0.1 9e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF1512 PF07431.12 EFC42468.1 - 0.03 13.3 0.0 0.064 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) GAGA_bind PF06217.12 EFC42468.1 - 1.8 8.8 10.9 3.3 7.9 10.9 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family Aminotran_5 PF00266.19 EFC42469.1 - 3.1e-43 148.1 0.0 4.5e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V HAD PF12710.7 EFC42469.1 - 2.4e-05 24.8 0.0 5.5e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFC42469.1 - 0.0023 18.0 0.7 0.12 12.4 0.1 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 EFC42469.1 - 0.0054 16.2 1.1 0.053 12.9 1.0 2.4 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.26 EFC42469.1 - 0.033 14.5 0.8 0.66 10.2 0.8 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase HORMA PF02301.18 EFC42471.1 - 1e-65 221.3 1.5 1e-65 221.3 1.5 2.0 2 0 0 2 2 2 1 HORMA domain FtsK_gamma PF09397.10 EFC42471.1 - 4e-06 26.5 0.0 1e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 Ftsk gamma domain Fe_dep_repress PF01325.19 EFC42471.1 - 0.00097 19.3 4.8 0.0011 19.1 2.0 2.6 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain MarR_2 PF12802.7 EFC42471.1 - 0.0012 18.7 0.0 0.0033 17.3 0.0 1.7 1 0 0 1 1 1 1 MarR family MarR PF01047.22 EFC42471.1 - 0.0033 17.3 0.1 0.017 15.1 0.1 2.2 1 0 0 1 1 1 1 MarR family Ribosomal_S25 PF03297.15 EFC42471.1 - 0.0044 17.2 1.2 0.0044 17.2 1.2 2.7 3 0 0 3 3 3 1 S25 ribosomal protein HTH_24 PF13412.6 EFC42471.1 - 0.011 15.3 0.0 0.027 14.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Mga PF05043.13 EFC42471.1 - 0.041 14.5 0.2 0.1 13.2 0.2 1.7 1 0 0 1 1 1 0 Mga helix-turn-helix domain TrmB PF01978.19 EFC42471.1 - 0.041 13.8 0.2 0.14 12.1 0.2 1.9 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.12 EFC42471.1 - 0.13 12.2 0.7 1.5 8.9 0.1 2.6 2 0 0 2 2 2 0 HTH domain eIF_4EBP PF05456.11 EFC42472.1 - 1e-33 115.7 0.7 1.1e-33 115.5 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Cellulose_synt PF03552.14 EFC42472.1 - 0.15 10.5 0.0 0.17 10.3 0.0 1.0 1 0 0 1 1 1 0 Cellulose synthase DPPIV_N PF00930.21 EFC42473.1 - 3.8e-67 226.5 5.0 5.4e-67 226.1 5.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 EFC42473.1 - 2e-42 145.1 0.1 3.6e-42 144.2 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFC42473.1 - 6.9e-07 29.1 0.5 1.4e-06 28.1 0.5 1.5 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EFC42473.1 - 0.0017 19.0 0.0 0.0044 17.6 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1100 PF06500.11 EFC42473.1 - 0.0045 15.9 0.6 0.15 10.9 0.0 2.6 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF1100) TMEM154 PF15102.6 EFC42473.1 - 0.0062 16.4 0.4 0.017 15.1 0.4 1.7 1 0 0 1 1 1 1 TMEM154 protein family AXE1 PF05448.12 EFC42473.1 - 0.0072 15.0 0.2 0.063 11.9 0.2 2.1 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) LIP PF03583.14 EFC42473.1 - 0.11 11.7 2.4 0.24 10.7 1.4 2.0 2 0 0 2 2 2 0 Secretory lipase STE2 PF02116.15 EFC42473.1 - 0.12 11.6 0.4 0.37 10.0 0.1 1.8 2 0 0 2 2 2 0 Fungal pheromone mating factor STE2 GPCR UPF0054 PF02130.17 EFC42474.1 - 8.1e-33 113.0 0.5 1.1e-32 112.5 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized protein family UPF0054 zf-C2H2 PF00096.26 EFC42475.1 - 3.7e-18 64.9 49.2 0.0001 22.6 0.3 6.5 6 0 0 6 6 6 6 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFC42475.1 - 3.1e-16 58.7 45.1 0.00069 20.2 0.3 6.5 6 0 0 6 6 6 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFC42475.1 - 5.6e-12 45.6 36.1 0.00066 19.9 0.8 6.7 6 1 0 6 6 6 5 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFC42475.1 - 2.1e-08 34.3 26.1 0.0099 16.2 0.4 6.7 6 1 0 6 6 6 3 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 EFC42475.1 - 9.6e-08 32.1 32.2 0.069 13.6 0.3 6.6 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 EFC42475.1 - 0.00055 19.9 0.1 0.00055 19.9 0.1 5.5 6 0 0 6 6 6 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 EFC42475.1 - 0.0012 19.1 19.9 0.027 14.8 7.9 3.7 1 1 2 4 4 4 2 C2H2-type zinc ribbon zf_Hakai PF18408.1 EFC42475.1 - 0.013 15.2 1.8 0.013 15.2 1.8 4.2 3 1 1 4 4 4 0 C2H2 Hakai zinc finger domain zf-C2H2_2 PF12756.7 EFC42475.1 - 0.093 13.1 31.3 1 9.7 1.5 4.5 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 EFC42475.1 - 0.1 13.3 25.3 6.5 7.4 6.2 5.1 2 1 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats FOXP-CC PF16159.5 EFC42475.1 - 0.32 11.7 23.8 0.47 11.1 0.4 5.4 2 1 4 6 6 6 0 FOXP coiled-coil domain OTT_1508_deam PF14441.6 EFC42475.1 - 6.2 6.9 11.1 7.3 6.7 0.2 3.5 2 1 0 3 3 3 0 OTT_1508-like deaminase Oxidored_FMN PF00724.20 EFC42476.1 - 4.1e-83 279.5 0.0 4.8e-83 279.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 EFC42476.1 - 0.11 11.9 0.0 0.47 9.9 0.0 2.1 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel IQ PF00612.27 EFC42477.1 - 1.6 8.7 4.4 0.35 10.8 0.5 2.1 2 0 0 2 2 2 0 IQ calmodulin-binding motif Sad1_UNC PF07738.13 EFC42478.1 - 8.1e-37 126.2 0.1 4.7e-36 123.7 0.1 2.3 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal Snapin_Pallidin PF14712.6 EFC42478.1 - 1.3e-21 76.8 0.3 1.3e-21 76.8 0.3 2.9 2 1 0 2 2 2 1 Snapin/Pallidin CorA PF01544.18 EFC42478.1 - 0.00061 19.2 9.2 0.016 14.5 0.8 2.4 2 0 0 2 2 2 2 CorA-like Mg2+ transporter protein DUF489 PF04356.12 EFC42478.1 - 0.52 10.3 8.8 5.8 6.9 0.7 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF489) DUF1672 PF07901.11 EFC42478.1 - 0.87 8.9 13.1 0.017 14.5 5.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1672) DUF1664 PF07889.12 EFC42478.1 - 1.3 9.1 11.4 0.26 11.3 0.6 3.3 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) SlyX PF04102.12 EFC42478.1 - 1.4 9.5 6.9 3 8.5 0.4 3.8 4 0 0 4 4 4 0 SlyX KxDL PF10241.9 EFC42478.1 - 1.7 9.0 8.3 0.21 11.9 0.9 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein Motile_Sperm PF00635.26 EFC42479.1 - 4.3e-08 33.0 4.5 0.027 14.3 0.0 4.5 4 1 0 4 4 4 3 MSP (Major sperm protein) domain ASH PF15780.5 EFC42479.1 - 9.9e-08 32.1 3.4 0.24 11.7 0.0 5.2 5 1 0 5 5 5 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin MYCBPAP PF14646.6 EFC42479.1 - 9.7e-05 21.5 0.1 0.00029 19.9 0.0 1.7 1 1 1 2 2 2 1 MYCBP-associated protein family TMEM131_like PF12371.8 EFC42479.1 - 0.012 15.9 0.8 0.73 10.1 0.0 3.4 4 0 0 4 4 4 0 Transmembrane protein 131-like AAA_13 PF13166.6 EFC42480.1 - 9.4 4.7 36.8 0.96 8.0 15.9 2.2 2 0 0 2 2 2 0 AAA domain PB1 PF00564.24 EFC42482.1 - 5.5e-05 23.0 0.1 0.00021 21.2 0.1 2.0 1 0 0 1 1 1 1 PB1 domain PIN_8 PF18476.1 EFC42482.1 - 0.038 13.9 4.5 0.068 13.0 4.5 1.3 1 0 0 1 1 1 0 PIN like domain Tox-GHH PF15636.6 EFC42482.1 - 0.19 11.7 0.8 0.66 10.0 0.1 2.2 2 0 0 2 2 2 0 GHH signature containing HNH/Endo VII superfamily nuclease toxin AI-2E_transport PF01594.16 EFC42482.1 - 0.27 10.4 1.1 0.42 9.7 1.1 1.2 1 0 0 1 1 1 0 AI-2E family transporter DUF2222 PF09984.9 EFC42482.1 - 0.92 9.4 7.9 18 5.2 7.9 2.4 1 1 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) Atrophin-1 PF03154.15 EFC42482.1 - 1.3 7.2 7.0 1.7 6.9 7.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family Complex1_LYR PF05347.15 EFC42483.1 - 2.4e-06 27.5 0.3 4.7e-06 26.6 0.3 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF2570 PF10828.8 EFC42485.1 - 0.02 14.7 1.4 0.03 14.1 1.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) ICE2 PF08426.10 EFC42485.1 - 0.025 13.7 0.1 0.029 13.5 0.1 1.1 1 0 0 1 1 1 0 ICE2 DUF3172 PF11371.8 EFC42485.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3172) WD40 PF00400.32 EFC42486.1 - 1.8e-17 63.4 13.0 0.00026 21.7 0.0 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42486.1 - 1.6e-14 53.9 5.3 5.7e-05 23.3 0.1 4.6 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC42486.1 - 0.013 14.5 0.1 0.21 10.5 0.0 2.5 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 EFC42486.1 - 0.027 13.5 0.5 0.18 10.8 0.1 2.2 2 0 0 2 2 2 0 Coatomer WD associated region Myb_DNA-bind_6 PF13921.6 EFC42487.1 - 1.6e-19 69.9 8.3 8.2e-13 48.4 3.1 3.1 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFC42487.1 - 1.3e-14 54.0 7.5 2.8e-11 43.4 0.8 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFC42487.1 - 0.00043 20.3 3.0 0.083 12.9 0.0 2.7 2 1 1 3 3 3 2 SLIDE Myb_DNA-bind_2 PF08914.11 EFC42487.1 - 0.00089 19.4 0.5 0.039 14.1 0.0 2.5 2 0 0 2 2 2 1 Rap1 Myb domain DUF3446 PF11928.8 EFC42487.1 - 0.019 15.2 8.6 0.26 11.6 0.7 2.7 3 0 0 3 3 3 0 Early growth response N-terminal domain YppG PF14179.6 EFC42487.1 - 0.054 14.2 2.9 0.054 14.2 2.9 2.5 1 1 1 2 2 2 0 YppG-like protein Rap1_C PF11626.8 EFC42487.1 - 0.14 12.3 2.7 0.58 10.3 0.4 2.3 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain JHY PF15261.6 EFC42488.1 - 2.8e-14 53.9 15.8 2.8e-14 53.9 15.8 4.5 4 3 0 4 4 4 1 Jhy protein Ribosomal_S13_N PF08069.12 EFC42489.1 - 7.6e-30 102.7 0.2 1.5e-29 101.8 0.2 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 EFC42489.1 - 1.1e-12 48.0 1.0 1.6e-12 47.5 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 HK97-gp10_like PF04883.12 EFC42489.1 - 0.013 16.5 0.1 0.042 14.8 0.0 1.9 2 1 0 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component RecX PF02631.16 EFC42489.1 - 0.047 14.2 0.2 7.8 7.0 0.0 2.1 2 0 0 2 2 2 0 RecX family HTH_32 PF13565.6 EFC42489.1 - 0.09 13.4 0.3 0.29 11.8 0.1 1.9 1 1 1 2 2 2 0 Homeodomain-like domain PAX PF00292.18 EFC42489.1 - 0.11 12.5 0.0 0.24 11.3 0.0 1.6 1 1 0 1 1 1 0 'Paired box' domain EF-hand_7 PF13499.6 EFC42490.1 - 3.7e-09 36.9 0.1 4.1e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EFC42490.1 - 3.3e-06 27.3 0.0 0.021 15.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 EFC42490.1 - 8.7e-06 25.3 0.0 0.17 11.9 0.0 3.5 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 EFC42490.1 - 0.00073 18.9 0.1 0.22 11.1 0.0 3.5 3 1 0 3 3 3 1 EF hand RNase_PH_C PF03725.15 EFC42490.1 - 0.013 15.5 0.6 0.31 11.1 0.0 2.9 3 1 0 3 3 3 0 3' exoribonuclease family, domain 2 TFIIE_beta PF02186.15 EFC42490.1 - 0.064 13.5 0.6 0.15 12.4 0.1 1.9 2 1 0 2 2 2 0 TFIIE beta subunit core domain DUF1456 PF07308.13 EFC42490.1 - 0.12 12.8 0.2 1.4 9.3 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) AAA PF00004.29 EFC42491.1 - 9.8e-14 51.9 3.0 6.1e-13 49.3 3.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC42491.1 - 1.9e-12 47.6 0.0 5.3e-11 42.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC42491.1 - 4.6e-08 33.6 0.0 2e-07 31.6 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 EFC42491.1 - 0.00037 20.1 0.1 0.00037 20.1 0.1 2.6 3 0 0 3 3 3 1 P-loop containing dynein motor region DUF2075 PF09848.9 EFC42491.1 - 0.00097 18.5 3.4 0.00097 18.5 3.4 2.0 2 1 0 2 2 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EFC42491.1 - 0.0015 18.9 0.1 0.012 16.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EFC42491.1 - 0.01 15.8 0.0 0.16 11.9 0.0 2.3 1 1 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 EFC42491.1 - 0.011 15.5 0.3 0.011 15.5 0.3 2.7 3 1 0 3 3 3 0 AAA domain AAA_24 PF13479.6 EFC42491.1 - 0.015 15.0 0.0 0.04 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFC42491.1 - 0.02 14.1 0.0 0.053 12.7 0.0 1.9 1 1 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 EFC42491.1 - 0.021 14.1 0.0 0.042 13.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Viral_helicase1 PF01443.18 EFC42491.1 - 0.021 14.5 0.4 0.11 12.2 0.0 2.3 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 EFC42491.1 - 0.029 14.3 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 EFC42491.1 - 0.12 12.4 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Folliculin PF11704.8 EFC42491.1 - 1.1 9.1 12.2 0.11 12.4 2.9 2.5 2 1 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport KRTAP PF11759.8 EFC42492.1 - 6.8e-08 32.9 151.3 1.8e+04 -109.5 151.3 6.6 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 EFC42492.1 - 0.19 11.9 147.6 1.8e+04 -33.1 70.0 7.3 1 1 1 2 2 2 0 Keratin type II head Actin PF00022.19 EFC42493.1 - 2.3e-142 474.4 0.0 9.4e-142 472.4 0.0 1.7 1 1 0 1 1 1 1 Actin NIT PF08376.10 EFC42494.1 - 6.6e-36 124.9 0.0 1.4e-35 123.9 0.0 1.6 1 0 0 1 1 1 1 Nitrate and nitrite sensing Guanylate_cyc PF00211.20 EFC42494.1 - 3e-26 92.2 0.0 6.9e-26 91.0 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain NIT PF08376.10 EFC42495.1 - 8.8e-39 134.3 0.0 2.7e-38 132.7 0.0 1.8 2 0 0 2 2 2 1 Nitrate and nitrite sensing Guanylate_cyc PF00211.20 EFC42495.1 - 8e-28 97.3 0.0 4.3e-27 94.9 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PIG-F PF06699.11 EFC42495.1 - 0.0039 17.4 0.2 0.014 15.5 0.2 1.9 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F LAP1C PF05609.12 EFC42495.1 - 0.051 12.7 15.6 0.083 12.0 15.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) T4bSS_IcmS PF12608.8 EFC42495.1 - 0.13 12.6 0.1 0.38 11.1 0.1 1.7 1 0 0 1 1 1 0 Type IVb secretion, IcmS, effector-recruitment Abhydrolase_1 PF00561.20 EFC42496.1 - 6.9e-07 29.2 0.2 2.7e-05 24.0 0.2 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Pkinase PF00069.25 EFC42497.1 - 2.3e-32 112.4 6.0 1.4e-30 106.5 1.1 3.2 2 1 0 2 2 2 1 Protein kinase domain Ank_2 PF12796.7 EFC42497.1 - 2.4e-21 76.1 3.1 4.9e-07 30.3 1.1 4.8 2 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC42497.1 - 8.3e-21 71.9 3.2 0.00014 22.0 0.1 7.0 6 1 1 7 7 7 4 Ankyrin repeat Ank PF00023.30 EFC42497.1 - 8.3e-18 64.0 1.5 5.2e-06 26.7 0.1 6.4 5 1 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFC42497.1 - 3.1e-17 62.7 0.3 5e-07 30.1 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC42497.1 - 1.1e-16 60.6 0.4 0.00032 20.9 0.0 5.5 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 EFC42497.1 - 2.2e-13 50.1 0.7 5.3e-08 32.5 0.4 2.7 2 0 0 2 2 2 2 Protein tyrosine kinase HTH_16 PF12645.7 EFC42497.1 - 0.028 14.5 0.3 0.074 13.1 0.3 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain TFIIE_beta PF02186.15 EFC42497.1 - 0.037 14.3 1.1 0.29 11.4 0.0 3.1 3 0 0 3 3 3 0 TFIIE beta subunit core domain Sel1 PF08238.12 EFC42498.1 - 2.6e-54 180.4 34.3 6.7e-08 33.0 0.0 10.9 11 0 0 11 11 11 8 Sel1 repeat Ras PF00071.22 EFC42499.1 - 3.5e-22 78.7 0.1 5.7e-22 78.1 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC42499.1 - 2.3e-08 34.3 0.1 9.3e-08 32.3 0.0 2.1 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC42499.1 - 1.4e-06 27.9 0.1 3e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC42499.1 - 0.00052 19.6 0.2 0.001 18.7 0.2 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMS19_N PF14500.6 EFC42499.1 - 0.0035 16.9 0.0 0.48 10.0 0.0 2.2 2 0 0 2 2 2 2 Dos2-interacting transcription regulator of RNA-Pol-II G-alpha PF00503.20 EFC42499.1 - 0.0049 16.1 6.4 0.22 10.6 0.0 2.7 1 1 1 3 3 3 2 G-protein alpha subunit F-box-like PF12937.7 EFC42499.1 - 0.006 16.4 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like MMR_HSR1_Xtn PF16897.5 EFC42499.1 - 0.016 15.2 2.9 0.12 12.4 1.5 2.4 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Oxidored_nitro PF00148.19 EFC42500.1 - 0.0026 16.5 0.0 0.0038 16.0 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase RasGEF PF00617.19 EFC42502.1 - 1.2e-54 185.2 3.4 1.2e-54 185.2 3.4 2.5 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFC42502.1 - 1.5e-20 73.4 1.2 1.5e-20 73.4 1.2 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif Str_synth PF03088.16 EFC42502.1 - 0.021 14.9 0.0 0.061 13.5 0.0 1.8 1 0 0 1 1 1 0 Strictosidine synthase Vac14_Fig4_bd PF11916.8 EFC42502.1 - 0.37 10.4 6.5 0.55 9.9 0.3 3.1 3 0 0 3 3 3 0 Vacuolar protein 14 C-terminal Fig4p binding DUF4355 PF14265.6 EFC42502.1 - 0.94 9.7 8.9 2.4 8.4 3.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) HIP1_clath_bdg PF16515.5 EFC42502.1 - 1.4 9.5 9.7 15 6.2 0.2 2.8 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 EF-G-binding_N PF07299.11 EFC42502.1 - 2.5 8.7 6.2 5.6 7.6 0.0 3.8 3 1 0 3 3 3 0 Elongation factor G-binding protein, N-terminal NOT2_3_5 PF04153.18 EFC42503.1 - 1.3e-29 102.9 2.2 1.3e-29 102.9 2.2 2.1 3 0 0 3 3 3 1 NOT2 / NOT3 / NOT5 family LPD22 PF18834.1 EFC42503.1 - 0.093 12.9 0.7 0.27 11.5 0.7 1.8 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 SSF PF00474.17 EFC42504.1 - 1.2e-74 251.6 34.3 4.9e-69 233.1 23.1 3.5 3 1 0 3 3 3 2 Sodium:solute symporter family TMEM154 PF15102.6 EFC42505.1 - 0.0013 18.6 1.0 0.0013 18.6 1.0 2.2 2 0 0 2 2 2 1 TMEM154 protein family ABC1 PF03109.16 EFC42506.1 - 2.6e-28 98.6 0.0 1.1e-27 96.6 0.0 2.1 2 0 0 2 2 2 1 ABC1 family Pkinase PF00069.25 EFC42506.1 - 0.014 14.8 1.3 0.068 12.5 0.2 2.3 1 1 0 2 2 2 0 Protein kinase domain TPR_19 PF14559.6 EFC42507.1 - 1.2e-43 147.4 33.3 6.6e-05 23.3 0.1 15.9 13 5 2 17 17 16 11 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42507.1 - 9.4e-34 112.8 47.5 3.7e-06 26.6 0.3 19.5 20 1 1 21 21 19 7 Tetratricopeptide repeat TPR_14 PF13428.6 EFC42507.1 - 2.7e-31 105.6 17.5 0.006 17.3 0.1 17.9 13 4 5 18 18 17 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFC42507.1 - 7e-31 106.6 1.0 0.00023 21.8 0.0 10.9 12 0 0 12 12 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC42507.1 - 1.3e-23 81.2 56.7 0.00026 20.9 0.6 18.2 20 0 0 20 20 18 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42507.1 - 1.1e-20 72.5 52.4 4.6e-07 29.4 0.6 15.7 18 0 0 18 18 17 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC42507.1 - 5.5e-20 70.2 23.7 7.1e-05 22.9 0.2 13.3 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42507.1 - 4.7e-17 62.0 40.6 0.00034 20.8 0.1 15.1 11 5 4 15 15 15 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42507.1 - 2.4e-16 58.5 26.3 0.028 14.4 0.1 14.1 14 1 0 14 14 13 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC42507.1 - 3.1e-16 59.4 43.3 0.00017 21.7 0.7 12.5 11 3 1 12 12 12 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFC42507.1 - 3.7e-16 58.5 31.0 5.8e-06 25.9 0.6 11.2 12 2 2 14 14 12 3 TPR repeat TPR_21 PF09976.9 EFC42507.1 - 5.8e-13 49.0 36.0 6.4e-06 26.0 1.7 6.9 6 1 1 7 7 6 5 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 EFC42507.1 - 5e-11 42.5 34.3 3.4 8.5 0.0 17.0 19 0 0 19 19 17 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC42507.1 - 5.9e-10 39.2 5.8 3.3 7.9 0.2 8.5 9 1 0 9 9 8 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFC42507.1 - 9e-07 28.6 3.8 0.29 10.8 0.0 7.0 4 4 4 8 8 8 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_MalT PF17874.1 EFC42507.1 - 0.00019 20.9 24.9 0.31 10.4 2.0 7.4 4 3 2 6 6 6 2 MalT-like TPR region TPR_20 PF14561.6 EFC42507.1 - 0.0097 16.2 25.9 1.4 9.3 0.1 8.6 6 2 2 8 8 8 1 Tetratricopeptide repeat DUF4250 PF14056.6 EFC42507.1 - 0.016 15.2 0.0 4.4 7.3 0.0 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) PknG_TPR PF16918.5 EFC42507.1 - 0.018 13.8 4.4 1.4 7.6 0.0 4.3 3 2 1 5 5 5 0 Protein kinase G tetratricopeptide repeat ChAPs PF09295.10 EFC42507.1 - 0.033 13.2 7.1 3.1 6.7 0.3 4.3 3 2 1 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) MIT PF04212.18 EFC42507.1 - 0.074 13.1 16.4 1.4 9.1 0.1 7.3 6 1 1 7 7 7 0 MIT (microtubule interacting and transport) domain Alkyl_sulf_dimr PF14863.6 EFC42507.1 - 0.094 13.2 13.5 6.7 7.2 0.2 6.4 5 1 1 6 6 5 0 Alkyl sulfatase dimerisation TPR_10 PF13374.6 EFC42507.1 - 0.095 12.6 29.4 0.4 10.6 0.1 10.3 14 0 0 14 14 10 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC42507.1 - 0.38 10.9 16.9 21 5.3 0.0 7.9 9 0 0 9 9 8 0 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 EFC42507.1 - 0.52 11.1 11.3 18 6.3 0.3 5.4 5 0 0 5 5 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC42507.1 - 1.3 8.5 11.6 8.9 5.9 0.0 6.3 7 0 0 7 7 7 0 SHNi-TPR Peptidase_C39_2 PF13529.6 EFC42508.1 - 3.9e-12 46.9 0.6 2.2e-11 44.5 0.0 2.2 2 0 0 2 2 2 1 Peptidase_C39 like family DASH_Duo1 PF08651.10 EFC42508.1 - 0.31 10.9 1.5 0.57 10.0 1.5 1.4 1 0 0 1 1 1 0 DASH complex subunit Duo1 DUF948 PF06103.11 EFC42508.1 - 0.52 10.6 3.6 1 9.6 3.6 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Fib_alpha PF08702.10 EFC42508.1 - 0.65 10.2 13.1 0.085 13.0 1.2 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family tRNA-synt_2 PF00152.20 EFC42509.1 - 1.7e-95 319.7 0.0 3e-95 318.9 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFC42509.1 - 7.2e-10 38.7 0.2 1.7e-09 37.5 0.2 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain GAD PF02938.14 EFC42509.1 - 3e-08 33.8 0.4 1e-07 32.1 0.4 2.0 1 0 0 1 1 1 1 GAD domain tRNA-synt_2b PF00587.25 EFC42509.1 - 0.014 15.3 3.1 0.025 14.5 0.3 2.5 2 1 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) MazE_antitoxin PF04014.18 EFC42509.1 - 0.029 14.3 0.1 0.068 13.1 0.1 1.6 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin tRNA-synt_2d PF01409.20 EFC42509.1 - 0.031 13.7 0.1 0.076 12.5 0.1 1.6 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) DUF4539 PF15072.6 EFC42509.1 - 0.042 13.9 0.3 0.17 12.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4539) PALP PF00291.25 EFC42510.1 - 1.4e-46 159.3 0.0 1.9e-46 158.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme G-alpha PF00503.20 EFC42511.1 - 3e-20 72.7 15.6 7e-20 71.5 15.6 1.6 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC42511.1 - 0.0075 15.7 0.6 0.019 14.3 0.2 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_18 PF13238.6 EFC42511.1 - 0.099 13.2 0.4 17 6.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain C2 PF00168.30 EFC42513.1 - 1.6e-17 63.7 0.0 3.2e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain Peptidase_C92 PF05708.12 EFC42513.1 - 2e-08 34.5 0.0 4.6e-05 23.6 0.0 2.4 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family zf-CSL PF05207.13 EFC42515.1 - 0.032 13.9 1.6 3 7.6 0.1 3.1 3 0 0 3 3 3 0 CSL zinc finger DUF5441 PF17513.2 EFC42516.1 - 0.0069 16.1 0.0 0.0091 15.8 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5441) Viral_Hsp90 PF03225.14 EFC42516.1 - 0.033 12.7 0.0 0.043 12.3 0.0 1.3 1 1 0 1 1 1 0 Viral heat shock protein Hsp90 homologue HSCB_C PF07743.13 EFC42516.1 - 0.058 13.9 2.1 0.11 13.0 2.1 1.5 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain OPA3 PF07047.12 EFC42516.1 - 0.065 13.0 1.3 0.088 12.6 0.5 1.6 2 0 0 2 2 2 0 Optic atrophy 3 protein (OPA3) XTBD PF11952.8 EFC42516.1 - 0.083 12.7 0.5 0.49 10.2 0.0 2.3 2 1 0 2 2 2 0 XRN-Two Binding Domain, XTBD Rx_N PF18052.1 EFC42516.1 - 0.099 12.9 1.8 0.16 12.3 1.8 1.3 1 0 0 1 1 1 0 Rx N-terminal domain DUF2576 PF10845.8 EFC42516.1 - 0.18 11.4 0.0 0.35 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) DUF1002 PF06207.11 EFC42516.1 - 1.2 8.7 8.3 6.6 6.2 4.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) TauD PF02668.16 EFC42517.1 - 4.5e-33 115.2 0.5 1.1e-32 114.0 0.1 1.7 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 EFC42517.1 - 0.00032 21.3 0.1 0.0084 16.7 0.1 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF971) Ago_PAZ PF18309.1 EFC42517.1 - 0.023 15.3 0.0 0.076 13.7 0.0 1.9 1 0 0 1 1 1 0 Argonaute PAZ domain BTB PF00651.31 EFC42518.1 - 1.6e-08 34.8 2.5 5.8e-08 32.9 0.2 3.1 4 0 0 4 4 4 1 BTB/POZ domain RGS PF00615.19 EFC42519.1 - 3.6e-08 33.7 5.6 1.4e-07 31.8 5.6 2.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain SAM_1 PF00536.30 EFC42519.1 - 8.3e-08 32.6 0.1 1.8e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cyclin_N PF00134.23 EFC42519.1 - 0.00043 20.0 0.2 0.0013 18.5 0.2 1.9 1 0 0 1 1 1 1 Cyclin, N-terminal domain SAM_2 PF07647.17 EFC42519.1 - 0.00045 20.3 0.1 0.001 19.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Ank_2 PF12796.7 EFC42520.1 - 1.2e-13 51.4 0.1 1.4e-10 41.6 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC42520.1 - 8.4e-09 35.8 0.0 0.0024 18.4 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42520.1 - 2.7e-07 30.4 0.0 0.00078 19.7 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFC42520.1 - 1.4e-05 25.2 0.0 0.02 15.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC42520.1 - 2.9e-05 24.3 0.0 0.38 11.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat SLC12 PF03522.15 EFC42520.1 - 1.1 8.2 31.5 0.066 12.2 12.8 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Nop14 PF04147.12 EFC42520.1 - 3.2 5.8 60.8 0.37 9.0 17.1 2.1 2 0 0 2 2 2 0 Nop14-like family RR_TM4-6 PF06459.12 EFC42520.1 - 9.9 5.9 52.7 5.7 6.7 14.4 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2428 PF10350.9 EFC42522.1 - 2.5e-55 187.7 0.6 3e-54 184.2 0.0 2.9 4 0 0 4 4 4 1 Putative death-receptor fusion protein (DUF2428) Erf4 PF10256.9 EFC42522.1 - 0.036 14.2 1.5 11 6.2 0.4 3.7 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family TPR_2 PF07719.17 EFC42523.1 - 5e-14 51.2 13.9 0.0074 16.3 0.0 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC42523.1 - 8.3e-14 50.7 17.3 0.00019 21.1 0.2 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat zf-MYND PF01753.18 EFC42523.1 - 2.3e-09 37.2 21.8 2.3e-09 37.2 21.8 2.6 3 0 0 3 3 3 1 MYND finger TPR_12 PF13424.6 EFC42523.1 - 3.7e-08 33.5 2.8 0.0079 16.5 0.3 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC42523.1 - 5.9e-07 29.8 1.4 0.15 12.9 0.0 5.1 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC42523.1 - 1.5e-06 28.7 0.1 0.037 14.7 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat Ank_2 PF12796.7 EFC42523.1 - 2.1e-05 25.0 0.0 0.00013 22.5 0.0 2.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) TPR_19 PF14559.6 EFC42523.1 - 4.3e-05 23.9 0.9 3.2 8.3 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat Ank_4 PF13637.6 EFC42523.1 - 5.8e-05 23.6 0.0 0.00022 21.7 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) ANAPC3 PF12895.7 EFC42523.1 - 0.00011 22.4 9.6 0.21 11.8 0.1 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 Ank_3 PF13606.6 EFC42523.1 - 0.00021 21.4 0.0 0.095 13.3 0.1 3.7 3 0 0 3 3 3 1 Ankyrin repeat TPR_11 PF13414.6 EFC42523.1 - 0.00026 20.6 12.4 0.071 12.8 0.3 5.2 4 1 1 5 5 5 1 TPR repeat Ank_5 PF13857.6 EFC42523.1 - 0.0019 18.5 0.0 0.057 13.8 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF3856 PF12968.7 EFC42523.1 - 0.0039 17.3 1.1 3.1 7.9 0.0 4.2 4 1 0 4 4 4 1 Domain of Unknown Function (DUF3856) TPR_8 PF13181.6 EFC42523.1 - 0.007 16.5 19.1 0.56 10.6 0.1 6.8 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42523.1 - 0.058 13.4 4.3 23 5.3 0.2 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Rhodanese_C PF12368.8 EFC42523.1 - 3.6 8.0 12.2 14 6.2 12.2 2.0 1 0 0 1 1 1 0 Rhodanase C-terminal TPR_6 PF13174.6 EFC42523.1 - 4.9 8.0 9.5 1e+02 3.9 0.0 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC42523.1 - 5.5 7.0 8.7 4.6 7.3 1.2 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF4386 PF14329.6 EFC42524.1 - 0.012 15.5 0.9 0.016 15.1 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) PTPA PF03095.15 EFC42525.1 - 1.7e-109 365.9 0.0 2.1e-109 365.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF3147 PF11345.8 EFC42526.1 - 1.8 8.9 18.9 0.14 12.6 1.3 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3147) DUF2842 PF11003.8 EFC42526.1 - 1.8 8.9 5.6 10 6.5 3.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2842) EF-hand_7 PF13499.6 EFC42527.1 - 4.8e-23 81.4 4.4 1.4e-12 47.9 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC42527.1 - 1.9e-18 64.5 4.2 0.00025 20.4 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC42527.1 - 1.2e-15 56.1 1.2 0.0014 18.4 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFC42527.1 - 2.6e-10 40.0 3.9 1.9e-06 27.6 0.3 2.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC42527.1 - 1e-09 37.4 0.3 0.0013 18.1 0.0 3.7 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.9 EFC42527.1 - 0.0031 17.8 2.3 0.17 12.2 0.3 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region p25-alpha PF05517.12 EFC42527.1 - 0.014 15.5 0.8 0.055 13.6 0.4 1.9 1 1 1 2 2 2 0 p25-alpha Cbl_N2 PF02761.14 EFC42527.1 - 0.027 15.2 3.3 0.62 10.8 0.9 2.2 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain DUF4734 PF15881.5 EFC42527.1 - 0.076 13.2 1.0 15 5.8 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4734) Colicin_immun PF09204.10 EFC42527.1 - 0.18 12.4 4.4 0.65 10.6 0.9 2.3 1 1 1 2 2 2 0 Bacterial self-protective colicin-like immunity DUF5638 PF18688.1 EFC42527.1 - 0.24 11.7 2.9 0.29 11.5 1.0 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5638) Ank_5 PF13857.6 EFC42528.1 - 6e-08 32.8 0.0 0.00013 22.2 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC42528.1 - 5.2e-07 30.2 0.0 0.0058 17.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFC42528.1 - 1.7e-05 25.1 0.0 0.23 12.0 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EFC42528.1 - 0.0014 18.9 0.1 17 6.4 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFC42528.1 - 0.07 13.7 0.5 2.8 8.6 0.0 2.8 3 0 0 3 3 3 0 Ankyrin repeats (many copies) BK_channel_a PF03493.18 EFC42529.1 - 7.6e-21 74.1 0.4 1.6e-18 66.7 0.2 3.1 3 0 0 3 3 3 2 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 EFC42529.1 - 3.8e-10 39.6 9.5 3.8e-10 39.6 9.5 2.5 2 0 0 2 2 2 1 Ion channel TrkA_N PF02254.18 EFC42529.1 - 6.3e-08 32.9 0.0 4.5e-06 26.9 0.0 2.8 2 0 0 2 2 2 1 TrkA-N domain Copine PF07002.16 EFC42530.1 - 8.1e-40 136.6 1.5 1.9e-38 132.1 1.5 2.8 1 1 0 1 1 1 1 Copine C2 PF00168.30 EFC42530.1 - 1.9e-20 73.1 0.9 9.5e-10 38.7 0.1 2.8 3 0 0 3 3 3 2 C2 domain vWA-TerF-like PF10138.9 EFC42530.1 - 0.0031 17.6 0.0 0.008 16.3 0.0 1.7 2 0 0 2 2 2 1 vWA found in TerF C terminus PBD PF00786.28 EFC42532.1 - 1.4e-12 47.7 0.1 4.1e-12 46.3 0.1 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain WH1 PF00568.23 EFC42532.1 - 2.6e-11 43.5 0.2 3.7e-11 42.9 0.2 1.3 1 0 0 1 1 1 1 WH1 domain zf-AN1 PF01428.16 EFC42534.1 - 3.5e-19 68.7 36.9 1.6e-10 41.0 17.1 2.7 3 0 0 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 EFC42534.1 - 1.3e-05 25.5 26.1 9.4e-05 22.7 6.3 2.7 2 1 0 2 2 2 2 Tc5 transposase C-terminal domain zf-C2H2_4 PF13894.6 EFC42534.1 - 1.1 10.3 18.3 1.8 9.6 4.8 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 EFC42534.1 - 2 9.0 16.4 7 7.3 4.1 3.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf_C2HC_14 PF18574.1 EFC42534.1 - 6.8 6.6 9.3 11 5.9 2.2 2.6 2 0 0 2 2 2 0 C2HC Zing finger domain zf-C3HC PF07967.13 EFC42534.1 - 8.4 6.4 12.7 2.3 8.3 2.0 2.8 2 1 0 2 2 2 0 C3HC zinc finger-like CobW_C PF07683.14 EFC42537.1 - 2.4e-07 30.6 0.4 1.1e-05 25.2 0.4 2.1 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain APOBEC_C PF05240.14 EFC42537.1 - 0.1 12.6 0.4 1.9 8.5 0.2 2.1 1 1 1 2 2 2 0 APOBEC-like C-terminal domain Ras PF00071.22 EFC42538.1 - 9.7e-53 178.1 1.5 1.2e-52 177.8 1.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC42538.1 - 1.3e-18 67.4 0.0 1.2e-17 64.2 0.0 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC42538.1 - 5.5e-10 39.0 0.1 8.2e-10 38.4 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC42538.1 - 0.00017 21.6 0.0 0.00027 21.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC42538.1 - 0.00028 20.8 0.7 0.063 13.2 0.1 2.6 2 1 1 3 3 3 1 RsgA GTPase ATPase_2 PF01637.18 EFC42538.1 - 0.0066 16.4 3.2 0.047 13.6 3.2 2.0 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Septin PF00735.18 EFC42538.1 - 0.012 14.9 0.0 0.02 14.2 0.0 1.5 1 1 0 1 1 1 0 Septin DAP3 PF10236.9 EFC42538.1 - 0.017 14.3 0.2 0.28 10.3 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AbiJ_NTD4 PF18863.1 EFC42538.1 - 0.026 15.0 0.9 0.037 14.5 0.9 1.4 1 1 0 1 1 1 0 AbiJ N-terminal domain 4 G-alpha PF00503.20 EFC42538.1 - 0.039 13.1 0.4 0.35 10.0 0.5 2.1 1 1 0 1 1 1 0 G-protein alpha subunit Viral_helicase1 PF01443.18 EFC42538.1 - 0.066 12.9 0.0 0.12 12.1 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase CbiA PF01656.23 EFC42538.1 - 0.14 12.2 0.0 3.6 7.6 0.0 2.6 2 1 1 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain RGS PF00615.19 EFC42540.1 - 4.1e-19 69.0 0.1 1e-12 48.3 0.0 2.5 2 0 0 2 2 2 2 Regulator of G protein signaling domain START PF01852.19 EFC42540.1 - 0.00064 19.2 0.0 0.00093 18.7 0.0 1.3 1 0 0 1 1 1 1 START domain Guanylate_cyc PF00211.20 EFC42541.1 - 2.9e-30 105.2 0.1 6.1e-30 104.2 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AF0941-like PF14591.6 EFC42541.1 - 0.18 12.4 4.9 0.11 13.1 1.2 2.5 2 0 0 2 2 2 0 AF0941-like DUF3149 PF11346.8 EFC42541.1 - 0.33 10.6 2.9 0.67 9.6 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) HTH_9 PF08221.11 EFC42541.1 - 0.96 9.6 4.2 1.3 9.2 1.5 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain PepX_C PF08530.10 EFC42542.1 - 8.2e-32 111.0 0.0 1.4e-31 110.2 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 EFC42542.1 - 4.4e-26 92.1 0.1 3.9e-16 59.4 0.0 2.1 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Fringe PF02434.16 EFC42543.1 - 0.017 14.5 0.0 0.35 10.2 0.0 2.4 2 0 0 2 2 2 0 Fringe-like G8 PF10162.9 EFC42545.1 - 3.3e-16 59.5 0.0 7.3e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 G8 domain CHRD PF07452.12 EFC42545.1 - 0.0019 19.2 0.0 0.0046 17.9 0.0 1.7 1 0 0 1 1 1 1 CHRD domain SH3_19 PF18597.1 EFC42545.1 - 0.068 13.0 0.2 0.31 10.9 0.2 2.1 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain Cyt-b5 PF00173.28 EFC42546.1 - 3.7e-07 30.2 0.0 5.3e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4834 PF16118.5 EFC42546.1 - 0.022 15.7 0.0 0.034 15.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Chordopox_A13L PF05961.11 EFC42546.1 - 0.035 14.4 0.4 0.78 10.0 0.0 2.8 3 0 0 3 3 3 0 Chordopoxvirus A13L protein NhaB PF06450.12 EFC42546.1 - 0.072 11.9 0.0 0.088 11.6 0.0 1.1 1 0 0 1 1 1 0 Bacterial Na+/H+ antiporter B (NhaB) LRR_4 PF12799.7 EFC42547.1 - 2.6e-05 24.5 22.0 0.29 11.6 0.3 7.4 7 2 2 9 9 9 4 Leucine Rich repeats (2 copies) Ribosomal_L12 PF00542.19 EFC42547.1 - 0.047 14.1 0.0 0.36 11.2 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain F-box-like PF12937.7 EFC42547.1 - 0.17 11.8 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 F-box-like EGF_2 PF07974.13 EFC42550.1 - 3e-13 49.9 83.4 0.00018 21.8 7.9 5.6 5 0 0 5 5 5 5 EGF-like domain NHL PF01436.21 EFC42550.1 - 3e-12 45.9 8.4 0.0088 16.0 0.2 7.1 6 0 0 6 6 6 3 NHL repeat SGL PF08450.12 EFC42550.1 - 0.0017 18.0 2.5 0.34 10.4 0.0 5.2 4 2 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region DUF4934 PF16288.5 EFC42550.1 - 0.063 13.2 2.6 16 5.4 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4934) YmzC PF14157.6 EFC42550.1 - 0.085 12.9 0.3 1.1 9.4 0.1 2.7 2 0 0 2 2 2 0 YmzC-like protein MNNL PF07657.13 EFC42552.1 - 0.53 10.4 8.4 1.3 9.1 8.4 1.7 1 0 0 1 1 1 0 N terminus of Notch ligand Exo_endo_phos PF03372.23 EFC42553.1 - 0.0035 16.9 0.0 0.012 15.2 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RRM_1 PF00076.22 EFC42554.1 - 5.9e-65 215.0 2.5 1.6e-21 75.9 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC42554.1 - 1.3e-07 31.7 0.3 0.17 12.1 0.0 3.7 2 1 1 3 3 3 3 RNA recognition motif RRM_5 PF13893.6 EFC42554.1 - 3.9e-06 26.5 0.1 0.045 13.3 0.0 3.3 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFC42554.1 - 2.5e-05 24.2 0.9 0.12 12.4 0.0 3.6 2 1 1 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 EFC42554.1 - 0.01 15.8 0.2 7.6 6.6 0.0 3.1 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EFC42554.1 - 0.014 15.6 2.0 3.1 8.0 0.2 4.0 3 2 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter DUF4523 PF15023.6 EFC42554.1 - 0.063 13.1 0.0 6.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Pkinase PF00069.25 EFC42555.1 - 1.8e-62 211.1 0.0 4e-62 210.0 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42555.1 - 2.5e-37 128.6 0.0 7e-37 127.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC42555.1 - 7.1e-06 25.0 5.3 0.0003 19.7 0.0 2.6 3 0 0 3 3 3 2 Fungal protein kinase Kinase-like PF14531.6 EFC42555.1 - 2.3e-05 23.9 0.0 0.00011 21.7 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EFC42555.1 - 0.003 17.2 0.1 0.006 16.2 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFC42555.1 - 0.05 13.5 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SgrR_N PF12793.7 EFC42555.1 - 0.13 12.5 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 Sugar transport-related sRNA regulator N-term Proteasome PF00227.26 EFC42556.1 - 2.1e-63 213.3 0.0 2.9e-63 212.8 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFC42556.1 - 3.6e-10 39.3 0.1 2.7e-09 36.5 0.0 2.2 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Guanylate_cyc PF00211.20 EFC42558.1 - 9.8e-55 185.0 0.5 9.8e-55 185.0 0.5 2.9 3 0 0 3 3 3 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC42558.1 - 1.4e-14 54.2 0.0 4.5e-14 52.6 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC42558.1 - 1.1e-08 35.1 0.0 4.2e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC42558.1 - 9.1e-05 22.4 0.1 0.004 17.1 0.0 3.1 3 0 0 3 3 3 1 PAS domain HNOBA PF07701.14 EFC42558.1 - 0.004 16.6 0.3 0.004 16.6 0.3 1.8 2 0 0 2 2 2 1 Heme NO binding associated WLM PF08325.10 EFC42558.1 - 0.09 12.8 0.1 0.22 11.6 0.1 1.6 1 0 0 1 1 1 0 WLM domain Orf78 PF06024.12 EFC42558.1 - 6.3 7.1 9.0 38 4.7 2.6 3.8 3 0 0 3 3 3 0 Orf78 (ac78) DUF1043 PF06295.12 EFC42558.1 - 7.4 6.6 7.4 2.7 8.0 3.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF5557 PF17712.1 EFC42559.1 - 0.053 13.5 0.1 0.17 11.8 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5557) Pro_isomerase PF00160.21 EFC42560.1 - 5.4e-22 78.7 0.1 8.7e-22 78.1 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 EFC42560.1 - 3.1e-11 42.6 1.1 0.00084 19.1 1.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42560.1 - 4.1e-09 35.8 0.6 0.0019 18.1 1.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42560.1 - 0.0001 22.0 0.1 0.45 10.7 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 EFC42560.1 - 0.0003 20.8 0.5 0.0012 18.9 0.5 2.0 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 EFC42560.1 - 0.00052 19.6 0.4 0.0024 17.5 0.3 2.2 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 EFC42560.1 - 0.00053 20.2 0.2 2.8 8.3 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC42560.1 - 0.0076 16.8 0.1 3.6 8.4 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.9 EFC42560.1 - 0.014 15.1 1.0 0.093 12.4 0.0 2.5 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_14 PF13428.6 EFC42560.1 - 0.11 13.3 0.0 13 6.9 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC42560.1 - 0.16 11.3 0.0 2.5 7.4 0.0 2.0 1 1 2 3 3 3 0 MalT-like TPR region Pkinase PF00069.25 EFC42561.1 - 1.6e-55 188.3 0.1 7.4e-42 143.5 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42561.1 - 2.7e-22 79.3 0.2 1.2e-15 57.5 0.0 3.1 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFC42561.1 - 0.049 13.6 0.0 0.088 12.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ALF PF03752.13 EFC42561.1 - 0.24 11.4 0.1 0.4 10.7 0.1 1.4 1 0 0 1 1 1 0 Short repeats of unknown function TFIIS_C PF01096.18 EFC42562.1 - 4.1e-19 68.1 9.6 4.1e-19 68.1 9.6 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EFC42562.1 - 0.00018 21.3 4.2 0.00018 21.3 4.2 3.5 3 1 0 3 3 3 1 RNA polymerases M/15 Kd subunit zf-C2H2_7 PF15269.6 EFC42562.1 - 0.00021 21.3 1.3 0.00041 20.4 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger Nudix_N_2 PF14803.6 EFC42562.1 - 0.011 15.6 2.4 0.011 15.6 2.4 3.2 3 1 0 3 3 3 0 Nudix N-terminal Zn_Tnp_IS1595 PF12760.7 EFC42562.1 - 0.045 13.7 14.0 0.28 11.2 0.6 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 EFC42562.1 - 0.083 12.3 0.0 0.083 12.3 0.0 3.9 4 0 0 4 4 4 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 EFC42562.1 - 0.13 12.2 9.3 0.37 10.8 1.0 3.3 3 0 0 3 3 3 0 PhnA Zinc-Ribbon zinc_ribbon_4 PF13717.6 EFC42562.1 - 0.55 10.2 15.9 1.8 8.5 2.7 3.7 4 0 0 4 4 4 0 zinc-ribbon domain Pkinase PF00069.25 EFC42563.1 - 3.1e-51 174.3 0.1 2.6e-50 171.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42563.1 - 7e-39 133.7 0.0 1.1e-38 133.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC42563.1 - 1.7e-21 76.6 3.6 6.7e-14 52.2 1.4 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC42563.1 - 9.4e-20 70.7 8.1 5.8e-12 45.9 0.4 2.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42563.1 - 2.5e-19 67.3 1.5 9.2e-06 25.6 0.1 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 EFC42563.1 - 4.3e-17 61.7 4.2 4.1e-05 23.8 0.2 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFC42563.1 - 6.8e-16 58.1 1.3 1.9e-09 37.6 0.5 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Pkinase_fungal PF17667.1 EFC42563.1 - 4.3e-06 25.7 0.0 7.4e-06 25.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC42563.1 - 0.0049 16.2 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFC42563.1 - 0.0058 16.3 0.1 3.7 7.1 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EFC42563.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL zf-met PF12874.7 EFC42564.1 - 2.7e-20 72.1 33.8 2e-06 28.0 0.3 5.9 5 0 0 5 5 5 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 EFC42564.1 - 7.5e-20 70.7 20.3 2.8e-05 24.3 0.2 4.6 4 0 0 4 4 4 4 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 EFC42564.1 - 4.6e-12 46.2 11.5 0.025 14.9 0.5 4.5 4 0 0 4 4 4 4 C2H2 type zinc-finger (2 copies) dsrm PF00035.26 EFC42564.1 - 2.8e-06 27.9 0.1 2.8e-06 27.9 0.1 2.5 3 0 0 3 3 1 1 Double-stranded RNA binding motif AKAP95 PF04988.12 EFC42564.1 - 1.6e-05 25.2 10.8 0.059 13.6 0.0 4.0 4 0 0 4 4 4 2 A-kinase anchoring protein 95 (AKAP95) OrsD PF12013.8 EFC42564.1 - 0.00011 22.7 12.8 0.11 12.9 0.8 4.2 3 1 0 4 4 4 2 Orsellinic acid/F9775 biosynthesis cluster protein D Dicer_dimer PF03368.14 EFC42564.1 - 0.00086 19.4 0.2 0.0065 16.6 0.0 2.6 2 0 0 2 2 2 1 Dicer dimerisation domain zf-C2H2_4 PF13894.6 EFC42564.1 - 0.0024 18.5 17.1 5.6 8.1 0.1 5.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-SCNM1 PF15803.5 EFC42564.1 - 0.027 14.1 9.1 1.7 8.3 0.1 3.8 3 0 0 3 3 3 0 Zinc-finger of sodium channel modifier 1 zf-C2H2 PF00096.26 EFC42564.1 - 0.032 14.7 1.7 0.032 14.7 1.7 5.5 5 0 0 5 5 4 0 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 EFC42564.1 - 0.29 10.8 14.9 1.2 8.9 0.1 4.6 4 0 0 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF629 PF04780.12 EFC42564.1 - 0.49 8.9 9.2 4.7 5.6 0.2 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF629) RMI1_N PF08585.12 EFC42566.1 - 0.0038 17.0 0.2 0.0052 16.6 0.2 1.2 1 0 0 1 1 1 1 RecQ mediated genome instability protein Usher PF00577.20 EFC42566.1 - 0.021 13.7 1.1 0.024 13.5 1.1 1.1 1 0 0 1 1 1 0 Outer membrane usher protein Orf78 PF06024.12 EFC42566.1 - 0.13 12.6 2.0 0.22 11.9 2.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) SMC_N PF02463.19 EFC42567.1 - 1.5e-24 86.7 0.8 2.1e-23 82.9 0.8 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFC42567.1 - 4.9e-23 82.7 10.1 4.9e-23 82.7 10.1 4.6 3 1 0 4 4 3 2 AAA domain AAA_21 PF13304.6 EFC42567.1 - 3.7e-06 27.0 7.5 0.036 13.9 0.0 3.6 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFC42567.1 - 9.8e-05 22.0 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain HAP1_N PF04849.13 EFC42567.1 - 0.031 13.5 49.0 0.036 13.3 16.1 3.8 2 1 1 3 3 3 0 HAP1 N-terminal conserved region AAA_27 PF13514.6 EFC42567.1 - 0.031 13.9 0.2 0.031 13.9 0.2 3.6 2 2 0 3 3 3 0 AAA domain DUF4535 PF15054.6 EFC42567.1 - 0.038 13.7 1.0 0.22 11.3 1.0 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) AAA_16 PF13191.6 EFC42567.1 - 0.052 13.9 0.7 0.28 11.6 0.0 2.6 4 0 0 4 4 4 0 AAA ATPase domain Spc7 PF08317.11 EFC42567.1 - 0.49 9.2 59.3 0.096 11.6 26.3 3.8 2 1 2 4 4 4 0 Spc7 kinetochore protein AAA PF00004.29 EFC42567.1 - 0.5 10.8 0.0 0.5 10.8 0.0 3.5 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) GvpK PF05121.12 EFC42567.1 - 8.2 6.5 11.9 1.6 8.8 0.2 4.8 4 1 2 6 6 6 0 Gas vesicle protein K DUF4116 PF13475.6 EFC42568.1 - 2.7e-28 97.4 24.5 6.6e-10 38.6 0.4 8.0 3 1 4 8 8 8 8 Domain of unknown function (DUF4116) Tri3 PF07428.11 EFC42568.1 - 0.18 10.7 0.5 6.1 5.6 0.1 2.2 2 0 0 2 2 2 0 15-O-acetyltransferase Tri3 DUF4116 PF13475.6 EFC42569.1 - 2.1e-21 75.4 8.4 1.6e-07 30.9 0.1 3.4 1 1 3 4 4 4 4 Domain of unknown function (DUF4116) RGS PF00615.19 EFC42570.1 - 0.0018 18.5 3.5 0.0025 18.1 1.3 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain Adap_comp_sub PF00928.21 EFC42571.1 - 8.9e-58 195.7 0.1 1.2e-57 195.3 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFC42571.1 - 1.3e-06 28.4 1.9 2.3e-06 27.6 1.9 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF3029 PF11230.8 EFC42571.1 - 0.081 11.3 0.0 0.12 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) DUF11 PF01345.18 EFC42571.1 - 0.12 12.7 0.7 0.33 11.3 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function DUF11 Smr PF01713.21 EFC42572.1 - 1.1e-11 44.9 0.0 2.3e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Smr domain CUE PF02845.16 EFC42572.1 - 3.6e-10 39.4 1.8 1.6e-06 27.6 0.1 4.3 4 0 0 4 4 4 2 CUE domain DUF1771 PF08590.10 EFC42572.1 - 0.00049 20.4 0.3 0.0014 18.9 0.3 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) DUF3464 PF11947.8 EFC42572.1 - 1 9.1 6.3 2.2 8.0 6.3 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Pkinase PF00069.25 EFC42573.1 - 9.7e-59 198.9 0.1 1.9e-58 197.9 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42573.1 - 3.3e-25 88.8 0.0 4.9e-25 88.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFC42573.1 - 5.9e-05 22.7 0.1 0.00011 21.8 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFC42573.1 - 0.00068 19.0 0.0 0.026 13.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFC42573.1 - 0.0038 16.1 0.0 0.0058 15.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC42573.1 - 0.0039 17.2 0.0 0.019 14.9 0.0 1.8 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC42573.1 - 0.0073 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQ-loop PF04193.14 EFC42574.1 - 6.6e-15 54.6 9.5 2e-14 53.1 0.3 3.1 2 1 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 EFC42574.1 - 3.9e-06 27.8 5.8 3.9e-06 27.8 5.8 2.2 1 1 2 3 3 3 1 ER lumen protein retaining receptor ECSCR PF15820.5 EFC42574.1 - 0.88 9.4 4.2 19 5.1 0.0 3.3 4 0 0 4 4 4 0 Endothelial cell-specific chemotaxis regulator LapA_dom PF06305.11 EFC42574.1 - 1.2 9.0 5.6 57 3.6 0.8 3.7 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain CLTH PF10607.9 EFC42575.1 - 3.1e-13 49.9 9.2 3.1e-13 49.9 9.2 2.0 1 1 1 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EFC42575.1 - 0.0015 18.4 0.5 0.0015 18.4 0.5 2.1 2 0 0 2 2 2 1 LisH SPRY PF00622.28 EFC42575.1 - 0.0054 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 SPRY domain FOP_dimer PF09398.10 EFC42575.1 - 0.054 13.7 0.4 0.054 13.7 0.4 2.4 2 1 1 3 3 3 0 FOP N terminal dimerisation domain YebO PF13974.6 EFC42575.1 - 6 7.0 6.6 1.5 8.9 2.6 2.1 2 0 0 2 2 2 0 YebO-like protein UCH PF00443.29 EFC42577.1 - 2.5e-34 119.0 1.6 3.1e-34 118.7 1.6 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC42577.1 - 2.5e-15 56.9 0.1 3.1e-15 56.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C3Hc3H PF13891.6 EFC42578.1 - 1.1e-21 76.9 7.6 6.5e-15 55.2 1.6 2.7 2 0 0 2 2 2 2 Potential DNA-binding domain Pox_G5 PF04599.12 EFC42578.1 - 0.083 11.9 0.9 0.14 11.2 0.9 1.2 1 0 0 1 1 1 0 Poxvirus G5 protein PMI_typeI PF01238.21 EFC42579.1 - 8.4e-91 304.9 0.5 9.8e-91 304.7 0.5 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 EFC42579.1 - 0.0056 16.6 0.0 0.57 10.1 0.1 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain SUIM_assoc PF16619.5 EFC42579.1 - 0.14 12.3 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 p450 PF00067.22 EFC42580.1 - 1.3e-72 245.1 0.2 1.5e-72 244.8 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 IFT57 PF10498.9 EFC42580.1 - 0.045 12.7 0.1 0.092 11.7 0.1 1.5 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF2011 PF09428.10 EFC42580.1 - 0.056 13.7 0.2 3.2 8.1 0.0 2.7 3 0 0 3 3 3 0 Fungal protein of unknown function (DUF2011) Phage_GPA PF05840.13 EFC42580.1 - 0.061 12.4 0.0 0.09 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) Cyclin_N PF00134.23 EFC42581.1 - 5.2e-15 55.3 2.6 1.5e-14 53.8 2.6 1.8 1 1 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC42581.1 - 2.9 8.0 8.1 0.31 11.1 0.6 3.0 2 1 1 4 4 4 0 Cyclin, C-terminal domain PPR_2 PF13041.6 EFC42582.1 - 2.6e-17 62.7 3.8 0.11 12.7 0.0 7.2 6 1 2 8 8 8 7 PPR repeat family PPR PF01535.20 EFC42582.1 - 4.8e-13 48.4 2.5 0.29 11.5 0.0 6.3 6 0 0 6 6 6 3 PPR repeat PPR_3 PF13812.6 EFC42582.1 - 5.3e-08 32.8 7.8 0.39 10.8 0.0 6.0 5 1 1 6 6 6 4 Pentatricopeptide repeat domain Annexin PF00191.20 EFC42582.1 - 0.0041 17.2 0.1 0.013 15.6 0.1 1.9 1 0 0 1 1 1 1 Annexin PPR_long PF17177.4 EFC42582.1 - 0.043 13.2 5.9 0.27 10.6 0.2 4.1 2 1 2 4 4 4 0 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EFC42582.1 - 0.069 13.0 2.8 15 5.5 0.1 3.9 3 1 2 5 5 5 0 Mitochondrial ATPase expression CRAL_TRIO PF00650.20 EFC42583.1 - 1.6e-20 73.4 0.9 2.4e-20 72.9 0.9 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFC42583.1 - 2.5e-07 30.9 0.4 4.2e-07 30.2 0.4 1.5 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC42583.1 - 0.0007 19.7 0.1 0.0017 18.5 0.1 1.8 1 1 0 1 1 1 1 CRAL/TRIO, N-terminal domain Response_reg PF00072.24 EFC42584.1 - 8.3e-21 74.2 0.9 4.2e-20 72.0 0.4 2.5 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 EFC42584.1 - 3e-18 66.4 1.0 3.1e-17 63.1 0.4 2.7 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC42584.1 - 2.4e-07 30.7 0.0 6.9e-07 29.2 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EFC42584.1 - 0.027 14.3 0.0 0.072 12.9 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Chordopox_A35R PF05989.12 EFC42584.1 - 0.032 14.1 1.1 0.11 12.3 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus A35R protein adh_short PF00106.25 EFC42585.1 - 1.7e-11 43.9 0.0 6.8e-09 35.5 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC42585.1 - 3.9e-06 26.6 0.0 0.0014 18.2 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC42585.1 - 1e-05 25.5 0.0 1.4e-05 25.1 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC42585.1 - 0.02 14.4 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family VIT_2 PF13757.6 EFC42588.1 - 0.047 13.6 0.5 0.13 12.2 0.5 1.8 1 0 0 1 1 1 0 Vault protein inter-alpha-trypsin domain RasGAP PF00616.19 EFC42589.1 - 3.7e-31 108.5 10.4 1.8e-30 106.2 3.9 3.2 2 1 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 EFC42589.1 - 3.9e-07 30.3 1.5 3.9e-07 30.3 1.5 2.1 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain SPG48 PF14764.6 EFC42589.1 - 0.2 12.1 1.7 4 7.9 0.0 3.6 4 0 0 4 4 4 0 AP-5 complex subunit, vesicle trafficking Lung_7-TM_R PF06814.13 EFC42590.1 - 1.2e-30 106.8 9.4 1.2e-30 106.8 9.4 1.6 2 0 0 2 2 2 1 Lung seven transmembrane receptor DUF2806 PF10987.8 EFC42590.1 - 0.18 11.7 0.0 0.47 10.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2806) RGS PF00615.19 EFC42592.1 - 4.1e-08 33.5 5.4 1.2e-07 32.1 5.4 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Guanylin PF02058.15 EFC42592.1 - 0.02 15.3 0.2 0.082 13.4 0.2 2.0 1 0 0 1 1 1 0 Guanylin precursor Baculo_11_kDa PF06143.11 EFC42592.1 - 3.9 7.1 8.8 0.74 9.4 2.3 2.6 2 0 0 2 2 2 0 Baculovirus 11 kDa family RGS PF00615.19 EFC42593.1 - 1.3e-07 31.9 6.8 5.2e-07 29.9 6.8 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain Ninjurin PF04923.12 EFC42593.1 - 0.01 15.8 0.8 0.031 14.2 0.8 1.8 1 0 0 1 1 1 1 Ninjurin DUF2207 PF09972.9 EFC42593.1 - 0.024 13.4 0.0 0.024 13.4 0.0 2.3 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) Guanylin PF02058.15 EFC42593.1 - 0.027 14.9 0.2 0.091 13.2 0.2 1.8 1 0 0 1 1 1 0 Guanylin precursor Ly49 PF08391.10 EFC42593.1 - 0.07 13.5 4.4 0.15 12.4 3.0 2.4 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region RWP-RK PF02042.15 EFC42594.1 - 3e-18 65.5 0.2 5.1e-18 64.8 0.2 1.4 1 0 0 1 1 1 1 RWP-RK domain Atx10homo_assoc PF09759.9 EFC42594.1 - 0.0056 16.7 2.4 0.016 15.2 2.4 1.8 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain HTH_Mga PF08280.11 EFC42594.1 - 0.034 14.2 0.1 0.081 13.0 0.1 1.6 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_17 PF12728.7 EFC42594.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 EFC42594.1 - 0.13 12.1 0.1 0.32 10.9 0.0 1.6 2 0 0 2 2 2 0 Homeodomain-like domain Met_10 PF02475.16 EFC42595.1 - 0.0061 16.3 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 Met-10+ like-protein LRR_6 PF13516.6 EFC42596.1 - 6.1e-14 50.8 0.0 1.9e-06 27.5 0.0 3.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_8 PF13855.6 EFC42596.1 - 7e-09 35.3 3.0 0.00061 19.5 0.1 3.1 3 1 2 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 EFC42596.1 - 3.1e-08 33.8 1.0 0.00025 21.4 0.0 3.3 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42596.1 - 0.00098 19.4 1.1 3.8 8.4 0.0 4.0 5 0 0 5 5 5 2 Leucine Rich Repeat Dynein_heavy PF03028.15 EFC42596.1 - 0.01 15.9 0.3 0.017 15.2 0.3 1.4 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain ApoB100_C PF12491.8 EFC42596.1 - 0.025 14.5 11.8 0.079 12.9 0.1 4.6 3 1 2 5 5 5 0 Apolipoprotein B100 C terminal PB1 PF00564.24 EFC42597.1 - 2.1e-05 24.4 0.7 2.1e-05 24.4 0.7 2.1 2 0 0 2 2 2 1 PB1 domain DUF4201 PF13870.6 EFC42598.1 - 0.11 12.2 40.0 0.038 13.7 21.1 4.6 2 2 2 4 4 4 0 Domain of unknown function (DUF4201) Osmo_CC PF08946.10 EFC42598.1 - 0.62 10.4 4.3 0.24 11.7 0.2 2.5 2 1 1 3 3 3 0 Osmosensory transporter coiled coil ERM PF00769.19 EFC42598.1 - 1.2 8.9 38.4 0.12 12.2 18.0 2.7 1 1 2 3 3 3 0 Ezrin/radixin/moesin family Rootletin PF15035.6 EFC42598.1 - 3.8 7.5 39.1 3.4 7.7 27.4 3.4 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion IF4E PF01652.18 EFC42599.1 - 1.1e-40 139.0 1.8 1.5e-40 138.6 1.8 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E NYD-SP28 PF14772.6 EFC42599.1 - 0.84 9.7 4.2 0.28 11.3 1.2 1.7 2 0 0 2 2 2 0 Sperm tail RCC1 PF00415.18 EFC42600.1 - 6.6e-10 39.5 0.6 0.0015 19.1 0.0 4.0 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC42600.1 - 7.5e-09 35.2 0.6 0.0099 15.7 0.0 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat ID PF18543.1 EFC42600.1 - 0.098 12.7 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Intracellular delivery domain PPR_2 PF13041.6 EFC42601.1 - 1.1e-134 438.6 51.7 2.8e-15 56.2 0.3 16.7 10 6 6 16 16 16 13 PPR repeat family PPR PF01535.20 EFC42601.1 - 3.3e-87 280.9 38.1 1.9e-07 30.8 0.1 27.2 29 0 0 29 29 28 10 PPR repeat PPR_3 PF13812.6 EFC42601.1 - 1.2e-83 275.2 44.9 2.4e-13 50.0 0.0 13.0 11 3 2 13 13 12 12 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC42601.1 - 3.1e-47 157.9 39.8 0.0029 17.3 0.0 21.0 22 0 0 22 22 22 13 PPR repeat PPR_long PF17177.4 EFC42601.1 - 5.8e-42 143.5 9.1 4e-09 36.1 0.0 8.2 2 2 7 9 9 9 8 Pentacotripeptide-repeat region of PRORP DYW_deaminase PF14432.6 EFC42601.1 - 2.2e-26 92.2 3.8 3.5e-26 91.5 0.6 3.1 3 0 0 3 3 2 1 DYW family of nucleic acid deaminases MRP-S27 PF10037.9 EFC42601.1 - 3.3e-14 52.6 15.7 0.11 11.3 0.1 8.0 5 3 4 9 9 9 5 Mitochondrial 28S ribosomal protein S27 TPR_19 PF14559.6 EFC42601.1 - 8.3e-14 51.9 0.0 1.5 9.4 0.0 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TUG-UBL1 PF11470.8 EFC42601.1 - 2e-10 40.7 3.1 0.0051 17.0 0.1 6.7 7 0 0 7 7 6 1 TUG ubiquitin-like domain ATP13 PF12921.7 EFC42601.1 - 2.3e-10 40.3 18.4 4.4 7.2 0.0 13.3 8 3 7 15 15 15 1 Mitochondrial ATPase expression Ocnus PF05005.15 EFC42601.1 - 1.1e-07 31.9 5.7 8.5 6.6 0.0 7.2 8 0 0 8 8 7 0 Janus/Ocnus family (Ocnus) PHB_acc PF05233.13 EFC42601.1 - 1.8e-06 27.9 1.0 35 4.5 0.0 7.5 7 0 0 7 7 7 0 PHB accumulation regulatory domain Katanin_con80 PF13925.6 EFC42601.1 - 1.4e-05 25.2 3.7 2.4 8.2 0.0 6.2 7 0 0 7 7 6 1 con80 domain of Katanin TPR_1 PF00515.28 EFC42601.1 - 1.6e-05 24.5 1.3 18 5.4 0.0 7.5 10 0 0 10 10 9 0 Tetratricopeptide repeat ECSIT PF06239.11 EFC42601.1 - 1.7e-05 24.1 10.4 3.5 6.7 0.0 7.6 9 0 0 9 9 9 1 Evolutionarily conserved signalling intermediate in Toll pathway RNHCP PF12647.7 EFC42601.1 - 0.0034 17.3 4.6 11 6.1 0.0 5.7 7 0 0 7 7 5 0 RNHCP domain Nrap PF03813.14 EFC42601.1 - 0.0038 17.3 9.2 30 4.6 0.1 6.3 5 1 1 6 6 6 0 Nrap protein domain 1 Clathrin PF00637.20 EFC42601.1 - 0.042 13.7 36.6 0.63 9.9 1.1 8.3 6 3 1 7 7 7 0 Region in Clathrin and VPS DUF5567 PF17722.1 EFC42601.1 - 0.048 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5567) Ufm1 PF03671.14 EFC42601.1 - 0.22 11.6 6.2 39 4.4 0.0 5.5 6 0 0 6 6 5 0 Ubiquitin fold modifier 1 protein NAGLU PF05089.12 EFC42601.1 - 0.48 9.3 5.2 3.5 6.5 0.1 3.5 5 0 0 5 5 5 0 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain Gag_p17 PF00540.18 EFC42601.1 - 0.83 9.6 7.2 6.9 6.7 0.0 4.5 5 0 0 5 5 4 0 gag gene protein p17 (matrix protein) Arg_repressor PF01316.21 EFC42601.1 - 2.6 7.9 14.8 31 4.4 0.0 6.5 7 0 0 7 7 7 0 Arginine repressor, DNA binding domain Peptidase_S15 PF02129.18 EFC42602.1 - 1.9e-43 149.0 0.0 4.5e-43 147.8 0.0 1.6 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 EFC42602.1 - 2.4e-20 73.4 0.0 3.7e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S9 PF00326.21 EFC42602.1 - 0.00082 18.9 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC42602.1 - 0.00087 19.0 0.3 0.0018 18.0 0.1 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC42602.1 - 0.00089 18.6 0.1 0.0018 17.6 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioredoxin_13 PF18401.1 EFC42602.1 - 0.0038 17.1 0.1 0.0076 16.2 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Methyltr_RsmB-F PF01189.17 EFC42604.1 - 3.6e-36 124.7 0.0 1.5e-35 122.7 0.0 1.9 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PUA PF01472.20 EFC42604.1 - 4.3e-07 29.8 1.4 7.1e-07 29.1 0.2 2.1 2 1 0 2 2 2 1 PUA domain FtsJ PF01728.19 EFC42604.1 - 5.5e-07 29.9 0.0 1.3e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 EFC42604.1 - 1.6e-05 24.4 0.0 0.07 12.4 0.0 2.3 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFC42604.1 - 1.8e-05 24.6 0.1 0.00017 21.4 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC42604.1 - 8.1e-05 23.2 0.1 0.00073 20.1 0.1 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC42604.1 - 0.002 18.8 0.1 2 9.1 0.0 2.8 1 1 1 2 2 2 2 Methyltransferase domain PCMT PF01135.19 EFC42604.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EFC42604.1 - 0.12 12.2 0.0 1.2 8.9 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain Antibiotic_NAT PF02522.14 EFC42604.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase Chlam_PMP PF02415.17 EFC42605.1 - 0.24 12.0 7.2 0.66 10.6 2.4 3.5 2 0 0 2 2 2 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF4116 PF13475.6 EFC42607.1 - 1.2e-181 588.4 78.2 4.8e-15 55.0 0.0 22.1 12 5 8 23 23 23 22 Domain of unknown function (DUF4116) IL6 PF00489.17 EFC42607.1 - 0.11 12.1 2.5 0.52 9.9 0.1 3.4 3 0 0 3 3 3 0 Interleukin-6/G-CSF/MGF family F-box-like PF12937.7 EFC42608.1 - 1.1e-08 34.8 0.4 5e-08 32.7 0.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC42608.1 - 1.6e-08 34.2 0.0 3.4e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 F-box domain MSP PF01716.18 EFC42611.1 - 0.052 12.8 0.0 0.11 11.7 0.0 1.5 2 0 0 2 2 2 0 Manganese-stabilising protein / photosystem II polypeptide Zn_clus PF00172.18 EFC42612.1 - 5.2e-09 36.1 11.6 1.1e-08 35.0 11.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_56 PF07429.11 EFC42613.1 - 0.12 11.5 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 4-alpha-L-fucosyltransferase glycosyl transferase group 56 RhoGEF PF00621.20 EFC42614.1 - 1.3e-38 133.1 0.9 1.3e-38 133.1 0.9 6.0 3 2 2 5 5 5 1 RhoGEF domain IQ PF00612.27 EFC42614.1 - 1.8e-13 49.0 70.0 0.29 11.0 0.3 20.7 25 0 0 25 25 25 10 IQ calmodulin-binding motif LRR_8 PF13855.6 EFC42614.1 - 4.7e-12 45.5 14.7 4.5e-07 29.5 5.2 3.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC42614.1 - 1e-05 25.8 30.5 0.00039 20.7 0.8 5.3 5 0 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42614.1 - 0.018 15.5 8.8 38 5.4 0.0 6.3 5 0 0 5 5 5 0 Leucine Rich Repeat Pkinase PF00069.25 EFC42615.1 - 6.1e-60 202.8 0.0 9.1e-60 202.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42615.1 - 5.6e-26 91.4 0.0 1.1e-25 90.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC42615.1 - 5.7e-06 25.8 0.0 3.8e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EFC42615.1 - 1.1e-05 25.1 0.7 5.9e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 EFC42615.1 - 0.0012 18.2 0.0 0.002 17.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC42615.1 - 0.24 11.3 0.0 1.3 8.9 0.0 2.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family zf-MYND PF01753.18 EFC42616.1 - 2e-12 47.0 18.6 1.1e-11 44.6 15.7 2.6 2 0 0 2 2 2 1 MYND finger DUF2271 PF10029.9 EFC42616.1 - 0.087 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) zf-C6H2 PF15801.5 EFC42616.1 - 0.78 10.1 12.4 2.1 8.7 12.4 1.8 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-Mss51 PF13824.6 EFC42616.1 - 2.3 8.4 9.1 6.7 6.9 9.1 1.9 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 PUB PF09409.10 EFC42617.1 - 3.4e-18 65.4 0.0 6.4e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 PUB domain Pkinase PF00069.25 EFC42617.1 - 2.9e-11 43.3 0.0 5.5e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42617.1 - 5.6e-05 22.6 0.0 0.00011 21.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC42617.1 - 0.035 13.4 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like NmrA PF05368.13 EFC42618.1 - 9.2e-26 90.8 0.7 1.2e-25 90.5 0.7 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC42618.1 - 5.3e-18 65.6 0.0 9.7e-18 64.7 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding Shikimate_DH PF01488.20 EFC42618.1 - 9.1e-05 22.5 0.3 0.00019 21.5 0.3 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EFC42618.1 - 0.0012 19.1 0.4 0.0026 18.0 0.4 1.5 1 1 0 1 1 1 1 TrkA-N domain DapB_N PF01113.20 EFC42618.1 - 0.0042 17.2 0.3 0.014 15.5 0.1 2.1 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus K_oxygenase PF13434.6 EFC42618.1 - 0.021 14.0 0.1 0.032 13.4 0.1 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Semialdhyde_dh PF01118.24 EFC42618.1 - 0.054 13.9 0.2 0.11 13.0 0.2 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 EFC42618.1 - 0.074 12.5 0.2 0.45 9.9 0.2 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF5406 PF17400.2 EFC42618.1 - 0.1 13.0 0.3 13 6.2 0.1 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5406) Pkinase PF00069.25 EFC42619.1 - 1.3e-23 83.7 0.0 1.7e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42619.1 - 2.2e-14 53.3 0.0 4e-14 52.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFC42619.1 - 1e-05 25.0 0.3 1.7e-05 24.3 0.1 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC42619.1 - 0.00011 21.6 0.0 0.00013 21.4 0.0 1.3 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EFC42619.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family NmrA PF05368.13 EFC42620.1 - 2.2e-23 83.1 1.0 3.3e-23 82.5 1.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC42620.1 - 4.6e-17 62.5 0.1 6.3e-16 58.8 0.1 2.4 2 1 0 2 2 2 1 NAD(P)H-binding Shikimate_DH PF01488.20 EFC42620.1 - 0.00019 21.5 0.4 0.00039 20.5 0.4 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EFC42620.1 - 0.00032 20.9 0.4 0.00067 19.9 0.4 1.5 1 1 0 1 1 1 1 TrkA-N domain DapB_N PF01113.20 EFC42620.1 - 0.0028 17.8 0.1 0.0077 16.4 0.1 1.9 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus K_oxygenase PF13434.6 EFC42620.1 - 0.019 14.1 0.1 0.029 13.5 0.1 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Epimerase PF01370.21 EFC42620.1 - 0.028 13.9 0.7 0.23 10.9 0.2 2.4 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFC42620.1 - 0.056 13.9 0.2 0.11 12.9 0.2 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFC42620.1 - 0.057 12.5 0.1 0.094 11.8 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein KR PF08659.10 EFC42620.1 - 0.1 12.5 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 KR domain CPT PF07931.12 EFC42620.1 - 0.11 12.3 0.1 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein NAD_binding_10 PF13460.6 EFC42621.1 - 1.1e-24 87.3 0.1 1.3e-24 87.1 0.1 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC42621.1 - 0.059 12.8 0.1 0.099 12.1 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family PP_kinase PF02503.17 EFC42621.1 - 0.078 12.6 0.1 0.18 11.4 0.1 1.5 1 1 0 1 1 1 0 Polyphosphate kinase middle domain DUF1122 PF06557.11 EFC42621.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1122) COesterase PF00135.28 EFC42621.1 - 0.19 10.5 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family DUF724 PF05266.14 EFC42622.1 - 0.14 11.9 3.2 0.21 11.4 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF334 PF03904.13 EFC42622.1 - 1.7 8.2 6.9 0.57 9.7 3.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF334) BET PF17035.5 EFC42623.1 - 8e-23 80.4 2.5 5e-22 77.9 0.5 2.7 2 0 0 2 2 2 1 Bromodomain extra-terminal - transcription regulation Bromodomain PF00439.25 EFC42623.1 - 1.4e-22 79.6 0.4 3e-22 78.5 0.4 1.6 1 0 0 1 1 1 1 Bromodomain Prefoldin PF02996.17 EFC42626.1 - 1.1e-25 89.8 3.2 1.1e-25 89.8 3.2 1.8 1 1 1 2 2 2 1 Prefoldin subunit Osmo_CC PF08946.10 EFC42626.1 - 0.0011 19.1 1.6 0.0011 19.1 1.6 2.8 2 1 1 3 3 3 1 Osmosensory transporter coiled coil Laminin_II PF06009.12 EFC42626.1 - 0.013 15.5 2.2 0.28 11.2 0.1 2.1 2 0 0 2 2 2 0 Laminin Domain II DUF3847 PF12958.7 EFC42626.1 - 0.041 14.0 2.7 0.047 13.8 0.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3847) Fib_alpha PF08702.10 EFC42626.1 - 0.056 13.6 0.6 0.056 13.6 0.6 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Rep_fac_C PF08542.11 EFC42626.1 - 0.083 13.3 0.2 0.37 11.2 0.0 2.0 2 0 0 2 2 2 0 Replication factor C C-terminal domain CALCOCO1 PF07888.11 EFC42626.1 - 0.17 10.7 7.0 0.083 11.7 1.1 2.0 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Occludin_ELL PF07303.13 EFC42626.1 - 0.2 12.4 9.1 0.078 13.7 2.5 2.2 2 0 0 2 2 2 0 Occludin homology domain Ribosomal_L4 PF00573.22 EFC42627.1 - 8.5e-38 130.0 1.8 1.2e-37 129.5 0.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 EFC42627.1 - 2.8e-21 75.4 2.5 2.8e-21 75.4 2.5 2.4 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain F-box-like PF12937.7 EFC42628.1 - 1.7e-05 24.6 0.0 0.011 15.6 0.0 2.5 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 EFC42628.1 - 0.06 13.2 0.2 2.8 7.9 0.0 3.0 3 0 0 3 3 3 0 F-box domain NHL PF01436.21 EFC42629.1 - 0.00013 21.8 3.6 0.25 11.5 0.1 3.7 3 0 0 3 3 3 3 NHL repeat Arylesterase PF01731.20 EFC42629.1 - 0.0043 17.2 0.0 6.3 7.1 0.0 2.8 2 0 0 2 2 2 2 Arylesterase TLD PF07534.16 EFC42630.1 - 1.2e-19 71.0 1.7 2e-19 70.2 1.7 1.4 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFC42630.1 - 0.0003 21.1 0.0 0.00054 20.3 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain CBM_6 PF03422.15 EFC42630.1 - 0.095 13.0 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding module (family 6) ENTH PF01417.20 EFC42631.1 - 2.5e-32 111.6 0.0 4.3e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 ENTH domain Polyketide_cyc PF03364.20 EFC42632.1 - 8e-11 42.3 0.0 1e-10 41.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EFC42632.1 - 1.2e-07 32.1 0.1 1.4e-07 31.9 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport YdjM PF04307.14 EFC42633.1 - 5e-06 25.9 5.1 1.5e-05 24.4 5.2 1.6 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase DUF4234 PF14018.6 EFC42633.1 - 0.67 10.1 7.2 0.39 10.9 0.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4234) PAP2_C PF14360.6 EFC42635.1 - 5.1e-22 78.2 9.8 5.1e-22 78.2 9.8 2.9 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EFC42635.1 - 5.4e-07 29.4 3.8 5.4e-07 29.4 3.8 2.3 1 1 1 2 2 2 1 PAP2 superfamily CitMHS PF03600.16 EFC42635.1 - 0.00044 19.5 0.4 0.00064 19.0 0.4 1.2 1 0 0 1 1 1 1 Citrate transporter PAP2_3 PF14378.6 EFC42635.1 - 0.47 10.1 10.9 1.3 8.6 10.9 1.8 1 1 0 1 1 1 0 PAP2 superfamily ABC_tran PF00005.27 EFC42636.1 - 8.8e-26 91.1 0.0 2.3e-25 89.7 0.0 1.8 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFC42636.1 - 1.2e-12 47.6 45.2 1.2e-12 47.6 45.2 1.8 2 1 0 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFC42636.1 - 1.5e-12 48.0 0.8 6.6e-10 39.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFC42636.1 - 0.0059 16.4 0.1 0.76 9.4 0.0 3.0 2 1 0 3 3 3 1 AAA ATPase domain SMC_N PF02463.19 EFC42636.1 - 0.014 14.9 2.0 0.36 10.2 0.0 2.7 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain SurA_N_3 PF13624.6 EFC42636.1 - 0.052 13.3 0.9 0.4 10.5 0.2 2.4 2 0 0 2 2 2 0 SurA N-terminal domain Pesticin PF16754.5 EFC42638.1 - 6.5e-60 201.5 3.8 1.5e-59 200.3 0.3 2.3 2 0 0 2 2 2 1 Bacterial toxin homologue of phage lysozyme, C-term Apt1 PF10351.9 EFC42638.1 - 1.2 7.9 11.0 1.4 7.7 11.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOBP PF15279.6 EFC42638.1 - 1.8 9.1 12.0 3.3 8.2 12.0 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Macoilin PF09726.9 EFC42638.1 - 7.3 5.0 12.5 10 4.5 12.5 1.3 1 0 0 1 1 1 0 Macoilin family Tubulin PF00091.25 EFC42639.1 - 3.2e-28 99.3 0.0 6.6e-28 98.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 EFC42639.1 - 6.5e-08 32.5 0.5 1.5e-07 31.2 0.1 1.8 2 0 0 2 2 2 1 Tubulin domain Ribosomal_L15e PF00827.17 EFC42640.1 - 4.3e-83 277.8 4.0 5e-83 277.5 4.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 RGS PF00615.19 EFC42641.1 - 9.2e-11 42.1 0.2 1.7e-10 41.2 0.2 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF505 PF04458.12 EFC42641.1 - 0.0086 14.5 0.3 0.012 14.0 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF505) NHL PF01436.21 EFC42642.1 - 2.2e-25 87.3 10.3 0.00019 21.3 0.1 6.4 6 0 0 6 6 6 6 NHL repeat BTB PF00651.31 EFC42642.1 - 4.3e-06 26.9 1.0 1.4e-05 25.3 1.0 2.0 1 1 0 1 1 1 1 BTB/POZ domain SGL PF08450.12 EFC42642.1 - 0.033 13.8 0.5 22 4.5 0.0 4.0 3 1 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Linker_histone PF00538.19 EFC42642.1 - 0.13 12.6 1.6 17 5.8 0.4 4.1 4 1 1 5 5 5 0 linker histone H1 and H5 family TRL PF13146.6 EFC42642.1 - 0.23 11.7 11.0 1.8 8.9 0.2 4.4 5 1 1 6 6 6 0 TRL-like protein family DUF1236 PF06823.12 EFC42642.1 - 4.4 7.2 6.1 54 3.8 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1236) Plasmo_rep PF12135.8 EFC42642.1 - 4.5 6.9 12.7 8 6.1 0.0 5.2 6 0 0 6 6 6 0 Plasmodium repeat family VCBS PF13517.6 EFC42645.1 - 1.4e-18 67.2 11.9 5.7e-05 23.6 0.2 5.6 4 1 1 5 5 5 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFC42645.1 - 0.00012 22.1 23.3 0.0012 18.9 0.1 5.0 5 0 0 5 5 5 4 FG-GAP repeat PliI PF16743.5 EFC42645.1 - 0.18 11.6 0.1 2.9 7.7 0.0 2.8 3 0 0 3 3 3 0 Periplasmic lysozyme inhibitor of I-type lysozyme RhoGAP PF00620.27 EFC42646.1 - 4.5e-27 94.8 0.1 1.5e-26 93.1 0.1 1.9 1 0 0 1 1 1 1 RhoGAP domain VWA PF00092.28 EFC42646.1 - 1.3e-23 84.1 3.1 1.3e-23 84.1 3.1 2.1 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC42646.1 - 3.4e-20 72.6 0.4 6.4e-20 71.7 0.4 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC42646.1 - 2.7e-15 56.9 3.0 4.7e-15 56.2 0.8 2.6 2 0 0 2 2 2 1 von Willebrand factor type A domain C2 PF00168.30 EFC42646.1 - 8.9e-09 35.6 0.1 0.0009 19.5 0.1 3.5 2 1 0 2 2 2 2 C2 domain VWA_CoxE PF05762.14 EFC42646.1 - 1.9e-05 24.2 0.0 3.2e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein DUF2201 PF09967.9 EFC42646.1 - 0.0053 16.9 0.2 0.026 14.7 0.2 2.2 2 0 0 2 2 2 1 VWA-like domain (DUF2201) CobT_C PF11775.8 EFC42646.1 - 0.13 11.9 0.3 0.29 10.8 0.1 1.7 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT VWA domain IFT81_CH PF18383.1 EFC42646.1 - 6.3 7.1 8.0 3 8.1 1.5 3.0 2 1 1 3 3 3 0 Intraflagellar transport 81 calponin homology domain SPRY PF00622.28 EFC42647.1 - 1.9e-06 28.0 0.0 3.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 SPRY domain FAD_binding_3 PF01494.19 EFC42648.1 - 8e-05 22.0 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFC42648.1 - 0.0017 18.5 0.1 0.038 14.2 0.0 2.7 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC42648.1 - 0.0053 16.4 0.2 0.027 14.0 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC42648.1 - 0.011 15.0 0.0 0.034 13.4 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HTH_Tnp_1_2 PF13022.6 EFC42648.1 - 0.03 14.5 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase Pyr_redox PF00070.27 EFC42648.1 - 0.035 14.7 0.3 0.57 10.8 0.1 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC42648.1 - 0.042 13.8 0.1 0.25 11.3 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding DDE_Tnp_1_7 PF13843.6 EFC42649.1 - 0.0014 18.0 0.0 0.0037 16.6 0.0 1.8 1 1 0 1 1 1 1 Transposase IS4 DUF4760 PF15956.5 EFC42649.1 - 0.078 13.1 1.8 0.12 12.5 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4760) FAD_binding_3 PF01494.19 EFC42650.1 - 5.2e-09 35.8 0.1 1.8e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DNApol_Exo PF18136.1 EFC42650.1 - 0.13 11.4 1.2 0.25 10.4 1.2 1.4 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain CCDC106 PF15794.5 EFC42650.1 - 0.47 10.1 8.7 1 9.0 8.7 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SR-25 PF10500.9 EFC42650.1 - 1.7 8.2 24.1 0.05 13.2 13.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Kinesin PF00225.23 EFC42651.1 - 2e-107 359.0 2.3 2e-107 359.0 2.3 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC42651.1 - 1.8e-27 96.1 2.5 3.8e-27 95.1 2.5 1.7 1 0 0 1 1 1 1 Microtubule binding PRCC PF10253.9 EFC42651.1 - 0.01 16.7 1.8 0.083 13.7 1.8 2.3 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting AAA_22 PF13401.6 EFC42651.1 - 0.085 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EFC42651.1 - 2.7 8.0 7.4 1.6 8.8 0.6 3.1 2 1 1 3 3 3 0 Helicase HerA, central domain Hydrolase_4 PF12146.8 EFC42652.1 - 1.6e-05 24.3 0.0 2.7e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC42652.1 - 0.00048 19.7 0.0 0.001 18.6 0.0 1.7 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFC42652.1 - 0.00063 20.4 0.0 0.00077 20.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC42652.1 - 0.0051 16.5 0.1 0.015 15.0 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold AXE1 PF05448.12 EFC42652.1 - 0.1 11.3 0.0 3.1 6.4 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) 2OG-FeII_Oxy_3 PF13640.6 EFC42653.1 - 1.2e-11 45.3 0.1 2.1e-11 44.5 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC42653.1 - 0.0069 16.8 0.0 0.019 15.5 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily dUTPase PF00692.19 EFC42655.1 - 8.5e-44 148.3 0.0 9.8e-44 148.2 0.0 1.0 1 0 0 1 1 1 1 dUTPase Colicin_D PF11429.8 EFC42655.1 - 0.12 12.9 0.0 0.46 11.0 0.0 1.9 2 0 0 2 2 2 0 Colicin D MIF4G PF02854.19 EFC42656.1 - 4.6e-49 166.9 36.7 2.4e-26 92.7 2.1 4.0 3 1 0 3 3 3 2 MIF4G domain DUF5327 PF17261.2 EFC42656.1 - 0.66 10.8 0.0 0.66 10.8 0.0 4.3 3 1 1 4 4 4 0 Family of unknown function (DUF5327) HAUS-augmin3 PF14932.6 EFC42657.1 - 5.2e-08 32.8 37.4 1.2e-07 31.6 25.5 4.5 2 2 0 2 2 2 1 HAUS augmin-like complex subunit 3 Pkinase PF00069.25 EFC42658.1 - 1.8e-09 37.4 0.6 2e-09 37.2 0.6 1.2 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 EFC42658.1 - 1.3e-06 28.5 0.0 1.4e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC42658.1 - 6.3e-05 22.4 0.3 9.4e-05 21.9 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 EFC42658.1 - 0.00056 19.6 0.4 0.00074 19.2 0.4 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 EFC42658.1 - 0.00079 18.8 0.7 0.0011 18.3 0.7 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFC42658.1 - 0.0028 17.3 1.3 0.0044 16.6 1.3 1.5 1 1 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 EFC42658.1 - 0.023 14.0 0.1 0.044 13.1 0.0 1.4 1 1 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EFC42658.1 - 0.033 13.8 0.2 0.052 13.2 0.1 1.3 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Ssu72 PF04722.13 EFC42659.1 - 2.3e-28 99.1 0.1 3.2e-28 98.6 0.1 1.2 1 0 0 1 1 1 1 Ssu72-like protein DUF2020 PF09449.10 EFC42659.1 - 7.8 6.3 6.3 0.3 10.9 0.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2020) PAPA-1 PF04795.12 EFC42660.1 - 5.8e-05 23.8 1.7 5.8e-05 23.8 1.7 2.4 1 1 1 2 2 2 1 PAPA-1-like conserved region CDC45 PF02724.14 EFC42660.1 - 0.68 8.2 20.7 0.77 8.0 20.7 1.0 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 EFC42660.1 - 3.1 4.8 12.0 3.4 4.7 12.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop53 PF07767.11 EFC42660.1 - 4.5 6.5 25.2 6.2 6.1 25.2 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RGS PF00615.19 EFC42661.1 - 1.6e-11 44.5 0.8 2.5e-11 43.9 0.8 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain SSP160 PF06933.11 EFC42661.1 - 0.062 11.5 6.1 0.079 11.2 6.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 HET-S PF17108.5 EFC42661.1 - 0.13 12.0 0.9 0.22 11.3 0.9 1.4 1 0 0 1 1 1 0 N-terminal small S protein of HET, non-prionic PAZ_siRNAbind PF12212.8 EFC42662.1 - 0.062 13.1 1.0 0.49 10.2 0.0 2.5 2 1 0 2 2 2 0 PAZ domain zinc_ribbon_12 PF11331.8 EFC42662.1 - 0.16 11.8 0.1 0.33 10.8 0.1 1.5 1 0 0 1 1 1 0 Probable zinc-ribbon domain DUF2587 PF10759.9 EFC42662.1 - 0.19 11.2 0.5 0.55 9.7 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2587) Cpn60_TCP1 PF00118.24 EFC42663.1 - 4e-07 29.0 0.0 4.7e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family REC1 PF18501.1 EFC42663.1 - 0.049 13.5 0.1 0.065 13.1 0.1 1.1 1 0 0 1 1 1 0 Alpha helical recognition lobe domain HXXSHH PF07586.11 EFC42663.1 - 0.16 11.5 0.0 0.19 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) Cpn60_TCP1 PF00118.24 EFC42664.1 - 9.6e-18 64.1 0.4 1.1e-17 63.8 0.4 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nudix_hydro PF18290.1 EFC42664.1 - 0.036 14.1 0.4 0.33 11.0 0.1 2.4 2 0 0 2 2 2 0 Nudix hydrolase domain UCH_N PF16674.5 EFC42664.1 - 0.11 12.4 3.1 5 7.1 0.1 2.5 2 0 0 2 2 2 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 Arrestin_C PF02752.22 EFC42665.1 - 4.6e-11 43.3 0.5 4.6e-11 43.3 0.5 2.9 2 1 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFC42665.1 - 7.4e-09 35.8 5.2 6.8e-08 32.7 1.3 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 EFC42665.1 - 0.004 16.9 0.0 0.0096 15.6 0.0 1.7 1 0 0 1 1 1 1 Arrestin_N terminal like AP3B1_C PF14796.6 EFC42665.1 - 0.072 13.4 0.1 0.2 11.9 0.1 1.8 1 0 0 1 1 1 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal Amidohydro_1 PF01979.20 EFC42666.1 - 3.6e-26 92.3 0.2 6.6e-26 91.4 0.2 1.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFC42666.1 - 1.6e-15 57.6 0.6 8.6e-07 28.8 0.0 2.7 2 1 1 3 3 3 2 Amidohydrolase family TPP_enzyme_M PF00205.22 EFC42666.1 - 0.029 14.1 0.5 0.088 12.6 0.0 1.9 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain WD40 PF00400.32 EFC42667.1 - 9.7e-28 95.9 21.2 0.00081 20.2 0.5 11.1 12 0 0 12 12 12 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42667.1 - 1.4e-16 60.6 4.3 7.7e-07 29.3 0.0 6.9 4 3 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC42667.1 - 1.9e-07 31.2 0.5 0.0022 17.9 0.0 4.3 3 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFC42667.1 - 2.2e-07 30.2 2.7 0.13 11.2 0.2 5.2 3 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFC42667.1 - 1.6e-05 23.8 3.3 0.012 14.3 0.0 2.9 3 1 0 3 3 3 2 Nucleoporin Nup120/160 IKI3 PF04762.12 EFC42667.1 - 0.00016 19.9 0.0 0.023 12.7 0.0 2.5 2 1 0 2 2 2 2 IKI3 family WD40_like PF17005.5 EFC42667.1 - 0.0084 15.5 8.5 4 6.7 0.0 4.2 3 1 2 5 5 5 3 WD40-like domain RAB3GAP2_N PF14655.6 EFC42667.1 - 0.074 12.3 0.0 2.4 7.3 0.0 2.9 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PD40 PF07676.12 EFC42667.1 - 0.21 11.6 1.9 4 7.5 0.0 3.8 4 1 1 5 5 5 0 WD40-like Beta Propeller Repeat TPR_1 PF00515.28 EFC42668.1 - 2.5e-49 163.2 2.2 7.7e-10 38.2 0.1 6.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42668.1 - 5e-39 129.3 1.2 1.8e-07 30.7 0.1 6.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFC42668.1 - 4.2e-34 116.0 4.4 2.5e-10 39.9 0.0 5.9 3 2 3 6 6 6 5 TPR repeat TPR_8 PF13181.6 EFC42668.1 - 4.5e-32 107.6 8.9 3.3e-07 30.0 0.0 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC42668.1 - 3.3e-18 64.7 4.2 0.0011 19.2 0.0 6.3 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42668.1 - 5.3e-17 61.9 0.5 4.8e-05 23.6 0.1 5.0 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC42668.1 - 9.1e-14 51.8 0.0 0.00028 21.5 0.0 3.5 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC42668.1 - 3.1e-13 49.7 0.0 0.0018 18.4 0.0 5.0 1 1 3 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42668.1 - 4.9e-11 41.8 0.5 0.0028 17.6 0.0 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC42668.1 - 8.8e-11 41.7 0.0 0.055 14.3 0.0 4.9 2 2 3 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC42668.1 - 9.7e-11 41.6 0.1 0.064 13.9 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC42668.1 - 3.3e-07 29.9 0.2 0.28 11.1 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC42668.1 - 6.7e-07 28.6 4.5 0.29 10.6 0.0 4.8 5 0 0 5 5 5 3 SHNi-TPR TPR_19 PF14559.6 EFC42668.1 - 6.8e-07 29.7 0.0 0.48 11.0 0.0 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_15 PF13429.6 EFC42668.1 - 1.1e-05 24.9 0.0 1 8.5 0.0 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC42668.1 - 4.3e-05 23.7 2.9 0.26 11.5 0.2 3.0 1 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EFC42668.1 - 0.00032 19.7 1.8 0.71 8.7 0.1 3.0 1 1 2 3 3 3 2 NMDA receptor-regulated protein 1 DUF3856 PF12968.7 EFC42668.1 - 0.0011 19.0 0.6 4.4 7.4 0.1 3.3 1 1 1 3 3 3 1 Domain of Unknown Function (DUF3856) ANAPC5 PF12862.7 EFC42668.1 - 0.0012 18.8 1.3 0.052 13.6 0.2 2.6 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 5 MIT PF04212.18 EFC42668.1 - 0.0018 18.3 3.3 17 5.6 0.1 4.2 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_20 PF14561.6 EFC42668.1 - 0.0026 18.1 0.0 2.9 8.3 0.0 3.2 2 1 2 4 4 4 1 Tetratricopeptide repeat DUF357 PF04010.13 EFC42668.1 - 0.0043 17.1 3.3 0.87 9.7 0.1 3.4 3 2 0 4 4 4 1 Protein of unknown function (DUF357) RPN7 PF10602.9 EFC42668.1 - 0.013 15.2 3.5 8.1 6.1 0.1 3.5 2 1 2 4 4 4 0 26S proteasome subunit RPN7 BTAD PF03704.17 EFC42668.1 - 0.037 14.5 0.0 3.9 7.9 0.0 3.1 3 1 1 4 4 3 0 Bacterial transcriptional activator domain NERD PF08378.11 EFC42668.1 - 0.046 14.2 0.0 0.097 13.1 0.0 1.6 1 0 0 1 1 1 0 Nuclease-related domain TPR_3 PF07720.12 EFC42668.1 - 2.9 8.0 7.9 41 4.3 0.1 4.3 4 1 1 5 5 5 0 Tetratricopeptide repeat eIF-3_zeta PF05091.12 EFC42669.1 - 1.1e-126 423.9 10.8 1.4e-126 423.6 10.8 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) YscJ_FliF_C PF08345.11 EFC42669.1 - 0.017 15.5 4.5 0.051 13.9 4.5 1.9 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal HCV_NS1 PF01560.17 EFC42669.1 - 0.14 10.8 0.0 0.21 10.2 0.0 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein E2/NS1 UPF0239 PF06783.11 EFC42669.1 - 8.2 6.7 7.6 29 4.9 7.6 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) VPS13_C PF16909.5 EFC42670.1 - 4.3e-50 169.9 8.8 8.6e-49 165.7 0.3 3.5 3 1 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EFC42670.1 - 2.5e-49 168.2 11.7 1.6e-47 162.3 6.0 4.0 3 0 0 3 3 3 1 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 EFC42670.1 - 2.3e-27 96.0 20.2 3.5e-24 85.6 0.8 4.4 4 1 1 5 5 5 2 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 EFC42670.1 - 8.7e-25 87.1 0.4 4.2e-24 84.9 0.4 2.4 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 VPS13_mid_rpt PF16910.5 EFC42670.1 - 3.2e-13 49.7 18.7 6.5e-12 45.4 4.8 5.8 5 2 1 6 6 6 2 Repeating coiled region of VPS13 ATG_C PF09333.11 EFC42670.1 - 2.4e-09 37.4 0.0 1.3e-08 35.1 0.0 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Rep_fac_C PF08542.11 EFC42670.1 - 0.0094 16.3 1.6 0.12 12.8 0.0 3.4 3 0 0 3 3 3 1 Replication factor C C-terminal domain DUF2591 PF10765.9 EFC42670.1 - 0.039 14.2 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) PH PF00169.29 EFC42670.1 - 0.096 13.2 5.1 0.061 13.8 0.4 3.4 3 0 0 3 3 3 0 PH domain E1_UFD PF09358.10 EFC42670.1 - 1.2 9.9 4.0 13 6.5 0.0 4.7 4 0 0 4 4 4 0 Ubiquitin fold domain SET PF00856.28 EFC42671.1 - 7.9e-19 68.7 2.5 7.9e-19 68.7 2.5 2.6 2 2 0 2 2 2 1 SET domain AWS PF17907.1 EFC42671.1 - 0.0038 17.2 14.0 0.0038 17.2 14.0 2.9 2 1 0 2 2 2 1 AWS domain TCR PF03638.15 EFC42671.1 - 2 8.8 26.0 0.044 14.1 15.4 2.9 2 0 0 2 2 2 0 Tesmin/TSO1-like CXC domain, cysteine-rich domain DAO PF01266.24 EFC42672.1 - 1.2e-31 110.6 0.0 1.4e-31 110.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC42672.1 - 0.014 14.7 0.0 0.68 9.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC42672.1 - 0.041 14.1 0.1 0.083 13.1 0.1 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFC42672.1 - 0.12 11.0 0.5 2.9 6.5 0.0 2.8 3 0 0 3 3 3 0 HI0933-like protein Mob1_phocein PF03637.17 EFC42673.1 - 5.3e-67 225.1 0.0 6.7e-67 224.7 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family Guanylate_cyc PF00211.20 EFC42674.1 - 2.4e-29 102.3 0.6 2.4e-29 102.3 0.6 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC42674.1 - 0.00037 20.4 2.7 0.00077 19.3 2.7 1.5 1 0 0 1 1 1 1 Cache domain COG4 PF08318.12 EFC42674.1 - 0.03 13.4 0.0 0.057 12.5 0.0 1.4 1 0 0 1 1 1 0 COG4 transport protein TP6A_N PF04406.14 EFC42675.1 - 4.2e-12 45.9 0.3 9.9e-12 44.7 0.3 1.7 1 0 0 1 1 1 1 Type IIB DNA topoisomerase 2OG-FeII_Oxy_3 PF13640.6 EFC42675.1 - 4.4e-06 27.5 0.1 9.9e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UQ_con PF00179.26 EFC42676.1 - 2e-44 150.6 0.1 2.3e-44 150.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC42676.1 - 0.00062 19.5 0.0 0.00077 19.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFC42676.1 - 0.035 14.4 1.0 0.042 14.1 0.9 1.4 1 1 0 1 1 1 0 RWD domain RNA_lig_T4_1 PF09511.10 EFC42678.1 - 3e-34 118.8 2.3 3e-34 118.8 2.3 1.8 2 0 0 2 2 2 1 RNA ligase DUF4743 PF15916.5 EFC42678.1 - 0.00043 20.2 0.2 0.097 12.6 0.0 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF4743) APC_N_CC PF16689.5 EFC42679.1 - 0.017 15.2 2.0 0.048 13.7 2.0 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Herpes_BLRF2 PF05812.12 EFC42679.1 - 0.035 14.3 0.9 0.091 12.9 0.9 1.7 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein DUF1043 PF06295.12 EFC42679.1 - 0.75 9.8 7.7 0.77 9.8 1.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) YabA PF06156.13 EFC42679.1 - 1 10.1 8.1 0.55 10.9 4.1 2.7 2 1 0 2 2 2 0 Initiation control protein YabA UQ_con PF00179.26 EFC42680.1 - 1.1e-54 183.8 0.1 1.3e-54 183.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC42680.1 - 8.7e-05 22.2 0.0 0.0001 22.0 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFC42680.1 - 0.023 15.0 0.1 0.028 14.7 0.1 1.3 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 EFC42680.1 - 0.049 13.5 0.1 0.087 12.7 0.1 1.4 1 1 0 1 1 1 0 UEV domain Occludin_ELL PF07303.13 EFC42681.1 - 0.042 14.6 2.4 0.096 13.4 0.6 2.6 2 0 0 2 2 2 0 Occludin homology domain HMMR_N PF15905.5 EFC42681.1 - 0.57 9.6 3.5 0.18 11.2 0.4 1.7 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal PB1 PF00564.24 EFC42682.1 - 6.7e-06 26.0 0.7 1.9e-05 24.5 0.7 1.8 1 0 0 1 1 1 1 PB1 domain LRR_6 PF13516.6 EFC42683.1 - 2.6e-70 226.6 29.0 6.5e-06 25.8 0.1 13.1 13 0 0 13 13 13 13 Leucine Rich repeat LRR_8 PF13855.6 EFC42683.1 - 5.8e-46 154.1 47.1 2.1e-09 37.0 0.6 5.6 2 2 6 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC42683.1 - 8.3e-35 118.2 46.4 4.1e-07 30.2 0.3 7.7 1 1 10 12 12 12 12 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42683.1 - 5.3e-22 75.0 6.3 3.9 8.4 0.0 12.4 13 0 0 13 13 13 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC42683.1 - 3.8e-06 26.5 8.9 0.02 14.4 0.8 3.4 1 1 2 4 4 4 3 Leucine-rich repeat ApoB100_C PF12491.8 EFC42683.1 - 3e-05 23.9 24.3 0.54 10.3 0.1 9.9 4 4 7 11 11 11 2 Apolipoprotein B100 C terminal HydF_dimer PF18128.1 EFC42683.1 - 0.0031 17.6 0.2 4.1 7.5 0.0 3.9 2 2 2 4 4 4 1 Hydrogen maturase F dimerization domain DUF424 PF04242.13 EFC42683.1 - 0.0041 17.4 10.0 16 5.8 0.1 5.6 1 1 5 8 8 8 1 Protein of unknown function (DUF424) Beta_helix PF13229.6 EFC42683.1 - 0.0056 16.5 3.1 0.0056 16.5 3.1 2.4 1 1 1 2 2 2 2 Right handed beta helix region NdhN PF11909.8 EFC42683.1 - 0.047 13.4 0.1 5.7 6.6 0.0 3.5 1 1 3 4 4 4 0 NADH-quinone oxidoreductase cyanobacterial subunit N LRR_6 PF13516.6 EFC42684.1 - 1.4e-44 146.4 23.0 0.00016 21.5 0.2 13.1 13 0 0 13 13 13 10 Leucine Rich repeat LRR_8 PF13855.6 EFC42684.1 - 5.1e-33 112.6 67.0 9.7e-08 31.7 1.9 6.9 2 1 7 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 EFC42684.1 - 1.7e-29 101.4 22.6 0.00011 22.5 0.0 7.7 6 1 0 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42684.1 - 2.4e-11 42.5 20.6 5.5 8.0 0.1 12.2 13 1 0 13 13 13 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC42684.1 - 9.1e-05 22.0 16.2 0.77 9.2 7.2 4.7 1 1 5 6 6 6 4 Leucine-rich repeat Dynein_heavy PF03028.15 EFC42684.1 - 0.051 13.7 0.2 0.14 12.2 0.2 1.7 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain ApoB100_C PF12491.8 EFC42684.1 - 0.49 10.4 28.4 18 5.4 0.0 10.2 6 3 7 13 13 13 0 Apolipoprotein B100 C terminal LRR_2 PF07723.13 EFC42684.1 - 2.2 9.1 3.8 50 4.8 0.0 5.3 6 0 0 6 6 6 0 Leucine Rich Repeat DUF5517 PF17639.2 EFC42684.1 - 2.7 8.3 8.5 10 6.5 0.2 4.9 2 1 1 5 5 5 0 Family of unknown function (DUF5517) SWI-SNF_Ssr4 PF08549.10 EFC42685.1 - 1.8 7.1 17.5 3.4 6.2 17.5 1.4 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Apolipoprotein PF01442.18 EFC42686.1 - 5e-09 36.3 14.2 6.1e-05 23.0 6.2 2.1 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain Prominin PF05478.11 EFC42686.1 - 0.00047 18.3 16.1 0.00061 17.9 16.1 1.2 1 0 0 1 1 1 1 Prominin DUF883 PF05957.13 EFC42686.1 - 0.00057 20.4 13.1 0.25 12.0 3.6 3.2 1 1 2 3 3 3 2 Bacterial protein of unknown function (DUF883) DUF2884 PF11101.8 EFC42686.1 - 0.0011 18.5 19.6 0.0027 17.3 18.8 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2884) Baculo_PEP_C PF04513.12 EFC42686.1 - 0.0046 17.0 15.1 0.044 13.8 9.9 3.2 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phe_tRNA-synt_N PF02912.18 EFC42686.1 - 0.006 16.5 0.7 0.006 16.5 0.7 5.2 1 1 3 5 5 5 1 Aminoacyl tRNA synthetase class II, N-terminal domain YtxH PF12732.7 EFC42686.1 - 0.0064 17.0 33.6 2.5 8.7 4.0 3.7 1 1 2 3 3 3 2 YtxH-like protein Tape_meas_lam_C PF09718.10 EFC42686.1 - 0.0087 16.2 0.7 3.2 7.9 0.0 3.0 2 1 0 3 3 3 1 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Phasin PF05597.11 EFC42686.1 - 0.013 15.6 26.5 0.91 9.5 7.3 3.1 1 1 3 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) AIP3 PF03915.13 EFC42686.1 - 0.013 14.6 21.0 0.015 14.4 21.0 1.0 1 0 0 1 1 1 0 Actin interacting protein 3 Tcp11 PF05794.13 EFC42686.1 - 0.02 14.0 6.5 0.024 13.8 6.5 1.2 1 0 0 1 1 1 0 T-complex protein 11 Toxin_trans PF07952.12 EFC42686.1 - 0.022 13.9 19.9 0.012 14.8 13.2 2.1 1 1 1 2 2 2 0 Clostridium neurotoxin, Translocation domain Mitofilin PF09731.9 EFC42686.1 - 0.049 12.5 28.4 0.095 11.5 28.2 1.5 1 1 0 1 1 1 0 Mitochondrial inner membrane protein hDGE_amylase PF14701.6 EFC42686.1 - 0.078 12.1 11.8 0.097 11.7 11.8 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Mst1_SARAH PF11629.8 EFC42686.1 - 0.083 13.0 4.6 0.22 11.6 4.2 1.9 2 0 0 2 2 1 0 C terminal SARAH domain of Mst1 T7SS_ESX_EspC PF10824.8 EFC42686.1 - 0.16 12.5 2.4 8 7.0 1.0 3.0 1 1 2 3 3 3 0 Excreted virulence factor EspC, type VII ESX diderm Mer2 PF09074.10 EFC42686.1 - 0.31 10.8 25.4 3 7.6 21.9 2.2 1 1 1 2 2 2 0 Mer2 DUF2130 PF09903.9 EFC42686.1 - 0.37 10.0 27.0 0.25 10.5 17.9 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) AI-2E_transport PF01594.16 EFC42686.1 - 0.5 9.5 6.2 0.15 11.2 2.0 2.0 1 1 1 2 2 2 0 AI-2E family transporter ApoLp-III PF07464.11 EFC42686.1 - 0.74 9.9 37.4 1.9 8.6 34.5 2.1 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) V-ATPase_G_2 PF16999.5 EFC42686.1 - 0.79 10.2 20.7 0.68 10.4 12.9 2.4 1 1 2 3 3 3 0 Vacuolar (H+)-ATPase G subunit GvpL_GvpF PF06386.11 EFC42686.1 - 0.83 9.5 10.2 2 8.3 10.2 1.6 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF PIN_8 PF18476.1 EFC42686.1 - 1 9.2 22.5 3.2 7.5 4.2 2.2 1 1 1 2 2 2 0 PIN like domain RB_A PF01858.17 EFC42686.1 - 1 9.1 11.6 2.1 8.2 8.0 2.6 1 1 2 3 3 3 0 Retinoblastoma-associated protein A domain Csa1 PF06023.12 EFC42686.1 - 1 8.6 11.7 1.2 8.4 1.0 2.1 1 1 1 2 2 2 0 CRISPR-associated exonuclease Csa1 REF PF05755.12 EFC42686.1 - 2.1 8.1 19.9 5.1 6.8 5.2 2.1 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) GBP_C PF02841.14 EFC42686.1 - 2.6 7.4 24.9 21 4.4 24.9 1.9 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Ku_C PF03730.14 EFC42686.1 - 3.1 8.5 19.2 1.5 9.6 1.5 2.9 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm Fzo_mitofusin PF04799.13 EFC42686.1 - 3.4 7.2 18.7 0.59 9.7 9.0 3.1 1 1 2 3 3 3 0 fzo-like conserved region ATP-synt_B PF00430.18 EFC42686.1 - 3.4 7.8 25.6 0.53 10.4 11.6 2.4 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) TipAS PF07739.13 EFC42686.1 - 3.6 8.2 13.3 11 6.6 4.7 2.9 1 1 2 3 3 3 0 TipAS antibiotic-recognition domain Mit_KHE1 PF10173.9 EFC42686.1 - 3.7 7.6 17.1 50 3.9 2.6 3.3 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related FdhE PF04216.12 EFC42686.1 - 3.8 7.3 9.9 17 5.2 9.4 1.9 1 1 1 2 2 2 0 Protein involved in formate dehydrogenase formation YlqD PF11068.8 EFC42686.1 - 3.9 7.9 28.4 0.79 10.1 17.9 2.5 1 1 1 2 2 2 0 YlqD protein BMFP PF04380.13 EFC42686.1 - 4.1 8.0 14.3 17 6.0 0.7 3.7 1 1 2 3 3 3 0 Membrane fusogenic activity CarD_CdnL_TRCF PF02559.16 EFC42686.1 - 5 7.9 18.9 2.6 8.8 1.2 3.2 2 1 1 3 3 3 0 CarD-like/TRCF domain ZYG-11_interact PF05884.12 EFC42686.1 - 6.6 6.1 14.3 11 5.3 7.0 2.4 1 1 1 2 2 2 0 Interactor of ZYG-11 Hydantoinase_A PF01968.18 EFC42686.1 - 6.7 5.9 15.7 0.89 8.8 3.4 2.7 1 1 2 3 3 3 0 Hydantoinase/oxoprolinase DUF45 PF01863.17 EFC42686.1 - 7.4 6.6 15.2 10 6.1 13.5 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF45 Actin PF00022.19 EFC42687.1 - 2.1e-107 359.2 0.0 6.5e-107 357.7 0.0 1.6 1 1 0 1 1 1 1 Actin adh_short_C2 PF13561.6 EFC42688.1 - 0.0047 16.5 0.0 0.0052 16.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC42688.1 - 0.033 13.6 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase HTH_IclR PF09339.10 EFC42688.1 - 0.082 12.7 0.1 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 IclR helix-turn-helix domain Zn_clus PF00172.18 EFC42689.1 - 0.043 13.9 0.4 0.088 12.9 0.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 EFC42690.1 - 1.2e-08 34.6 4.0 2.3e-08 33.7 4.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC42690.1 - 1.1e-07 31.0 0.9 2.1e-07 30.1 0.9 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC42690.1 - 1.4e-07 31.1 0.3 2.5e-07 30.3 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EFC42690.1 - 0.016 14.7 0.2 0.15 11.6 0.2 2.3 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL APH PF01636.23 EFC42690.1 - 0.017 15.0 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFC42690.1 - 0.037 13.6 1.0 0.088 12.4 1.0 1.7 1 1 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 EFC42690.1 - 0.11 11.7 0.6 0.18 11.1 0.6 1.3 1 0 0 1 1 1 0 Kinase-like Pkinase_Tyr PF07714.17 EFC42690.1 - 0.2 10.9 2.4 0.33 10.2 2.4 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase CitMHS PF03600.16 EFC42691.1 - 1.2e-24 87.0 1.0 1.2e-24 87.0 1.0 2.3 1 1 1 2 2 2 2 Citrate transporter ArsB PF02040.15 EFC42691.1 - 1.2e-23 84.2 17.8 1.6e-12 47.5 6.4 2.6 2 0 0 2 2 2 2 Arsenical pump membrane protein OAD_gamma PF04277.13 EFC42691.1 - 0.27 11.9 1.8 1.9 9.1 0.1 3.2 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain SBDS PF01172.18 EFC42692.1 - 1.2e-30 105.4 2.4 1.2e-30 105.4 2.4 2.3 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EFC42692.1 - 1.2e-30 105.9 2.3 2e-30 105.2 0.8 2.2 2 0 0 2 2 2 1 SBDS protein C-terminal domain Actin PF00022.19 EFC42693.1 - 2.7e-79 266.7 0.1 2.4e-74 250.4 0.0 2.2 1 1 0 2 2 2 2 Actin Transposase_21 PF02992.14 EFC42694.1 - 0.014 14.6 1.0 0.2 10.8 0.1 2.4 2 0 0 2 2 2 0 Transposase family tnp2 zf-Di19 PF05605.12 EFC42694.1 - 4.7 7.6 10.6 90 3.5 10.6 2.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 EFC42694.1 - 6.9 6.4 8.1 5.9 6.6 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Fra10Ac1 PF09725.9 EFC42695.1 - 8.7e-32 109.8 1.0 1.5e-31 109.0 1.0 1.5 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 START PF01852.19 EFC42695.1 - 2.6e-07 30.2 0.0 3.8e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 START domain WD40 PF00400.32 EFC42696.1 - 7.6e-38 127.9 23.4 4e-05 24.3 0.1 12.6 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42696.1 - 2e-11 44.0 0.2 0.45 10.8 0.0 6.9 5 3 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain FERM_M PF00373.18 EFC42697.1 - 6.4e-21 74.9 0.0 1e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 FERM central domain RA PF00788.23 EFC42697.1 - 1.2e-06 29.1 0.1 2.8e-06 27.9 0.1 1.8 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_N PF09379.10 EFC42697.1 - 6.5e-05 22.8 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain ACBP PF00887.19 EFC42697.1 - 0.00013 22.1 0.1 0.00056 20.1 0.0 2.0 2 0 0 2 2 2 1 Acyl CoA binding protein IRS PF02174.17 EFC42697.1 - 0.0012 18.7 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 PTB domain (IRS-1 type) Gag_p10 PF02337.17 EFC42698.1 - 0.036 14.0 0.1 0.063 13.2 0.1 1.3 1 0 0 1 1 1 0 Retroviral GAG p10 protein DUF829 PF05705.14 EFC42699.1 - 2.1e-20 73.7 0.0 2.6e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) ABC_membrane_2 PF06472.15 EFC42700.1 - 7.8e-74 248.5 2.6 1.1e-73 248.0 2.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFC42700.1 - 2.9e-16 60.2 0.0 5.8e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 EFC42700.1 - 0.00027 21.5 0.0 0.00061 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 EFC42700.1 - 0.00036 20.5 0.1 0.00071 19.5 0.1 1.6 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFC42700.1 - 0.0016 18.2 0.4 0.004 16.9 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF2079 PF09852.9 EFC42700.1 - 0.0073 15.2 0.2 0.0073 15.2 0.2 1.5 2 0 0 2 2 2 1 Predicted membrane protein (DUF2079) AAA_16 PF13191.6 EFC42700.1 - 0.0086 16.5 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 EFC42700.1 - 0.04 13.8 0.1 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_30 PF13604.6 EFC42700.1 - 0.047 13.4 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 EFC42700.1 - 0.083 12.3 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 EFC42700.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 EFC42700.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 EFC42700.1 - 0.14 11.2 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 T2SSE PF00437.20 EFC42700.1 - 0.14 11.2 0.3 0.29 10.2 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein ABC_membrane PF00664.23 EFC42701.1 - 2.2e-64 217.8 14.4 2.9e-64 217.4 14.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC42701.1 - 6.4e-32 110.9 0.0 1.4e-31 109.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC42701.1 - 4.3e-08 32.9 0.8 3.2e-07 30.0 0.8 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABA_GPCR PF12430.8 EFC42701.1 - 0.022 14.5 4.4 0.059 13.1 4.4 1.7 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor Zeta_toxin PF06414.12 EFC42701.1 - 0.025 13.9 0.0 0.061 12.6 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin TniB PF05621.11 EFC42701.1 - 0.031 13.7 0.1 4.1 6.8 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_29 PF13555.6 EFC42701.1 - 0.063 13.0 0.2 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 EFC42701.1 - 0.074 13.0 0.0 18 5.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EFC42701.1 - 0.077 12.9 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Peptidase_C2 PF00648.21 EFC42702.1 - 1e-86 290.7 0.2 1.4e-86 290.2 0.2 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EFC42702.1 - 2e-20 73.5 0.0 3.7e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Calpain large subunit, domain III Collagen PF01391.18 EFC42703.1 - 4e-07 29.7 41.2 3.2e-05 23.6 20.7 5.5 4 1 0 4 4 4 2 Collagen triple helix repeat (20 copies) NmrA PF05368.13 EFC42704.1 - 1.7e-27 96.5 0.9 2.2e-27 96.1 0.9 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC42704.1 - 3.7e-19 69.3 0.0 6.8e-19 68.5 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding Shikimate_DH PF01488.20 EFC42704.1 - 0.00018 21.6 0.4 0.0004 20.5 0.4 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EFC42704.1 - 0.0003 21.1 0.2 0.00055 20.2 0.2 1.5 1 0 0 1 1 1 1 TrkA-N domain DapB_N PF01113.20 EFC42704.1 - 0.0027 17.8 0.3 0.0086 16.2 0.1 2.0 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus K_oxygenase PF13434.6 EFC42704.1 - 0.022 13.9 0.1 0.034 13.3 0.1 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Epimerase PF01370.21 EFC42704.1 - 0.026 14.0 0.6 0.18 11.2 0.2 2.4 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC42704.1 - 0.059 12.5 0.1 0.098 11.8 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EFC42704.1 - 0.059 13.8 0.2 0.11 12.9 0.2 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 EFC42704.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.5 1 0 0 1 1 1 0 KR domain CPT PF07931.12 EFC42704.1 - 0.12 12.2 0.1 0.3 10.9 0.0 1.7 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Mito_carr PF00153.27 EFC42705.1 - 9.8e-63 208.1 4.6 3.2e-21 75.1 0.0 3.2 2 1 1 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 EFC42705.1 - 1.4e-23 80.7 9.6 2.4e-06 26.7 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFC42705.1 - 1.8e-23 82.8 3.6 3.8e-12 46.5 0.0 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC42705.1 - 2e-19 67.8 7.1 0.00089 19.0 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFC42705.1 - 1.2e-17 62.5 10.6 1.8e-05 24.0 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFC42705.1 - 4e-12 45.8 5.9 0.00057 19.7 0.0 4.2 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC42705.1 - 2.5e-11 43.9 1.8 1.1e-05 25.7 0.4 3.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC42705.1 - 0.023 14.7 6.0 5.8 6.9 0.2 3.7 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand WD40 PF00400.32 EFC42706.1 - 1.2e-22 79.7 28.4 8.2e-06 26.5 0.4 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42706.1 - 5.6e-05 23.4 0.2 0.039 14.2 0.0 4.1 2 2 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC42706.1 - 0.0032 16.2 2.5 0.66 8.5 0.3 3.9 2 1 0 3 3 3 1 Nucleoporin Nup120/160 Kelch_6 PF13964.6 EFC42706.1 - 0.19 12.1 2.5 30 5.1 0.0 4.3 4 0 0 4 4 4 0 Kelch motif Pkinase PF00069.25 EFC42707.1 - 6e-77 258.6 1.0 9.9e-77 257.9 0.2 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42707.1 - 7.1e-42 143.5 0.6 1.4e-41 142.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC42707.1 - 1.2e-07 31.4 0.1 1e-06 28.3 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFC42707.1 - 0.0012 18.2 0.2 0.0022 17.4 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC42707.1 - 0.0046 16.9 0.0 0.34 10.8 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family DUF3372 PF11852.8 EFC42707.1 - 0.028 13.9 0.3 0.061 12.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) FTA2 PF13095.6 EFC42707.1 - 0.087 12.4 0.2 0.19 11.3 0.2 1.6 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 NAF PF03822.14 EFC42707.1 - 0.099 12.8 0.0 0.39 10.9 0.0 2.1 1 0 0 1 1 1 0 NAF domain EF-hand_7 PF13499.6 EFC42708.1 - 6.5e-18 65.0 2.1 3.6e-09 36.9 0.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC42708.1 - 2.1e-14 51.9 8.0 2.3e-06 26.8 0.9 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC42708.1 - 2.6e-12 45.6 5.0 0.001 18.8 0.5 3.9 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFC42708.1 - 5.3e-09 35.2 5.6 4e-06 26.1 0.5 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC42708.1 - 1.6e-08 34.3 1.0 5.8e-05 22.9 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 EFC42708.1 - 0.026 14.9 0.0 4.2 7.8 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain RelB_N PF18506.1 EFC42708.1 - 0.056 13.3 1.8 0.33 10.8 0.5 2.6 3 0 0 3 3 3 0 RelB Antitoxin alpha helical domain SPARC_Ca_bdg PF10591.9 EFC42708.1 - 0.12 12.8 1.5 5.8 7.3 0.4 2.9 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Homez PF11569.8 EFC42709.1 - 0.023 14.1 0.1 0.039 13.4 0.1 1.3 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez RYDR_ITPR PF01365.21 EFC42710.1 - 1.8e-30 105.9 3.5 2.9e-16 59.5 2.1 6.7 9 0 0 9 9 9 2 RIH domain RIH_assoc PF08454.11 EFC42710.1 - 4.7e-27 93.8 2.9 4.7e-27 93.8 2.9 6.4 5 1 1 6 6 6 1 RyR and IP3R Homology associated Ins145_P3_rec PF08709.11 EFC42710.1 - 1.7e-21 76.4 8.4 2.7e-21 75.7 0.2 3.7 3 1 0 3 3 3 1 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 EFC42710.1 - 4.3e-20 72.3 16.7 3.7e-17 62.8 0.7 4.2 3 1 0 3 3 3 2 MIR domain Ion_trans PF00520.31 EFC42710.1 - 0.00025 20.3 16.2 0.00051 19.3 16.2 1.6 1 0 0 1 1 1 1 Ion transport protein DUF1889 PF08986.10 EFC42710.1 - 0.11 12.9 0.1 3.1 8.2 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1889) DUF3037 PF11236.8 EFC42710.1 - 0.63 10.5 2.6 3.2 8.2 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3037) DUF1911 PF08929.10 EFC42710.1 - 2 9.3 12.2 6.6 7.6 0.1 4.8 4 0 0 4 4 4 0 Domain of unknown function (DUF1911) bZIP_2 PF07716.15 EFC42713.1 - 0.23 11.6 3.3 0.51 10.5 3.3 1.7 1 0 0 1 1 1 0 Basic region leucine zipper RPE65 PF03055.15 EFC42714.1 - 4.6e-108 362.4 0.1 5.2e-108 362.2 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Peptidase_C2 PF00648.21 EFC42715.1 - 7.1e-56 189.4 0.1 1.1e-54 185.5 0.1 2.0 1 1 0 1 1 1 1 Calpain family cysteine protease DUF1479 PF07350.12 EFC42716.1 - 1.3e-10 40.6 0.0 9.1e-05 21.4 0.0 3.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 EFC42716.1 - 0.0003 21.1 0.0 0.019 15.2 0.0 2.6 3 0 0 3 3 3 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1839 PF08893.10 EFC42716.1 - 0.11 11.7 0.0 0.66 9.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1839) ydhR PF08803.11 EFC42717.1 - 1.4e-43 146.7 0.0 1.6e-43 146.6 0.0 1.0 1 0 0 1 1 1 1 Putative mono-oxygenase ydhR DUF4116 PF13475.6 EFC42718.1 - 2.3e-48 161.7 8.3 2.4e-12 46.4 0.0 6.7 4 2 2 6 6 6 6 Domain of unknown function (DUF4116) DUF1981 PF09324.10 EFC42718.1 - 0.019 14.8 0.0 0.074 12.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) Peptidase_C2 PF00648.21 EFC42719.1 - 3.7e-60 203.5 1.3 1.3e-53 182.0 0.1 3.0 2 1 0 2 2 2 2 Calpain family cysteine protease AP3D1 PF06375.11 EFC42719.1 - 6.5 7.0 10.5 0.37 11.0 4.8 1.7 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Guanylate_cyc PF00211.20 EFC42720.1 - 2.9e-30 105.3 0.3 6e-30 104.2 0.3 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain TFCD_C PF12612.8 EFC42721.1 - 1.3e-50 171.8 0.7 2.7e-49 167.6 0.0 3.2 3 0 0 3 3 3 1 Tubulin folding cofactor D C terminal HEAT_EZ PF13513.6 EFC42721.1 - 1.4e-07 31.8 11.0 0.14 12.7 0.0 8.4 7 2 3 10 10 10 2 HEAT-like repeat HEAT_2 PF13646.6 EFC42721.1 - 9.8e-07 29.1 4.3 0.1 13.0 0.1 5.3 6 0 0 6 6 6 2 HEAT repeats Cnd1 PF12717.7 EFC42721.1 - 5.7e-06 26.5 7.1 0.18 11.8 0.0 5.9 5 2 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFC42721.1 - 8.1e-06 25.7 11.1 0.86 10.0 0.0 8.1 8 0 0 8 8 8 1 HEAT repeat Vac14_Fab1_bd PF12755.7 EFC42721.1 - 0.00017 22.1 2.5 11 6.7 0.0 5.8 6 1 0 6 6 6 1 Vacuolar 14 Fab1-binding region TAF6_C PF07571.13 EFC42721.1 - 0.00065 20.0 4.1 1.2 9.5 0.0 5.3 5 0 0 5 5 5 1 TAF6 C-terminal HEAT repeat domain RICTOR_M PF14666.6 EFC42721.1 - 0.31 10.8 3.2 1.6 8.6 0.0 3.5 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, middle domain Cnd3 PF12719.7 EFC42721.1 - 1.4 8.0 6.2 1.5 7.9 0.2 3.6 4 1 0 4 4 4 0 Nuclear condensing complex subunits, C-term domain Pkinase PF00069.25 EFC42722.1 - 5.7e-13 48.8 0.0 1.2e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Acetyltransf_19 PF18015.1 EFC42722.1 - 0.00077 19.6 2.2 0.2 11.8 0.3 2.6 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Fimbrial_PilY2 PF14481.6 EFC42723.1 - 0.013 15.1 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 RVP_2 PF08284.11 EFC42725.1 - 0.047 13.5 0.1 0.094 12.5 0.1 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease LRR_9 PF14580.6 EFC42726.1 - 1.3e-07 31.3 1.3 3.8e-07 29.8 1.3 1.8 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EFC42726.1 - 8.2e-06 25.5 6.7 3.2e-05 23.6 2.3 2.7 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFC42726.1 - 0.0034 17.8 6.7 0.11 13.0 0.4 2.9 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) CheB_methylest PF01339.17 EFC42726.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 CheB methylesterase Med9 PF07544.13 EFC42727.1 - 0.00073 19.6 14.5 0.009 16.1 4.6 2.3 1 1 1 2 2 2 2 RNA polymerase II transcription mediator complex subunit 9 AIP3 PF03915.13 EFC42727.1 - 0.0018 17.4 11.6 0.0022 17.2 11.6 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 SKA2 PF16740.5 EFC42727.1 - 0.0029 17.4 9.8 0.0045 16.7 9.8 1.3 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 EzrA PF06160.12 EFC42727.1 - 0.0076 14.5 6.3 0.0085 14.3 6.3 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Dynactin_p22 PF07426.11 EFC42727.1 - 0.011 15.6 8.3 0.014 15.3 8.3 1.2 1 0 0 1 1 1 0 Dynactin subunit p22 Apolipoprotein PF01442.18 EFC42727.1 - 0.015 15.2 0.5 0.019 14.8 0.5 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Spc7 PF08317.11 EFC42727.1 - 0.032 13.1 9.9 0.04 12.8 9.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Spectrin PF00435.21 EFC42727.1 - 0.034 14.6 5.7 0.057 13.9 5.7 1.3 1 0 0 1 1 1 0 Spectrin repeat Baculo_p24 PF05073.12 EFC42727.1 - 0.045 13.5 6.4 0.064 13.0 6.4 1.3 1 0 0 1 1 1 0 Baculovirus P24 capsid protein Leu_zip PF15294.6 EFC42727.1 - 0.057 12.9 11.6 0.076 12.5 11.6 1.2 1 0 0 1 1 1 0 Leucine zipper YscO PF07321.12 EFC42727.1 - 0.057 13.4 2.7 0.075 13.0 2.7 1.2 1 0 0 1 1 1 0 Type III secretion protein YscO GARP PF16731.5 EFC42727.1 - 0.058 13.1 2.0 0.11 12.2 2.0 1.5 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma APG17 PF04108.12 EFC42727.1 - 0.064 12.4 7.2 0.11 11.6 7.2 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 DUF4201 PF13870.6 EFC42727.1 - 0.073 12.8 14.8 0.094 12.4 14.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) OSCP PF00213.18 EFC42727.1 - 0.082 13.0 5.0 0.27 11.3 5.0 1.8 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit CorA PF01544.18 EFC42727.1 - 0.083 12.2 0.6 0.11 11.7 0.6 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Vac_Fusion PF02346.16 EFC42727.1 - 0.09 12.4 7.0 1 9.1 0.7 2.7 2 2 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 BLOC1_2 PF10046.9 EFC42727.1 - 0.1 12.9 10.7 0.7 10.2 1.9 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AGOG PF09171.10 EFC42727.1 - 0.12 11.7 9.4 0.16 11.3 9.4 1.2 1 0 0 1 1 1 0 N-glycosylase/DNA lyase YlbD_coat PF14071.6 EFC42727.1 - 0.16 12.2 9.1 0.42 10.9 2.3 2.3 1 1 1 2 2 2 0 Putative coat protein Cob_adeno_trans PF01923.18 EFC42727.1 - 0.2 11.8 1.8 0.27 11.4 1.8 1.1 1 0 0 1 1 1 0 Cobalamin adenosyltransferase CLZ PF16526.5 EFC42727.1 - 0.22 11.9 5.6 0.21 12.0 1.3 2.7 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Exonuc_VII_L PF02601.15 EFC42727.1 - 0.26 10.8 7.0 0.27 10.7 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.9 EFC42727.1 - 0.34 10.9 9.3 0.74 9.8 9.3 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UPF0242 PF06785.11 EFC42727.1 - 0.45 10.6 12.7 0.53 10.4 12.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 EFC42727.1 - 0.48 10.5 8.2 0.83 9.7 6.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 EFC42727.1 - 0.56 10.4 8.2 0.57 10.4 1.8 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF2203 PF09969.9 EFC42727.1 - 0.95 10.2 4.8 2.1 9.1 4.8 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) GCN5L1 PF06320.13 EFC42727.1 - 1 9.5 10.8 2.3 8.4 10.8 1.6 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Pox_A_type_inc PF04508.12 EFC42727.1 - 1.1 9.2 5.7 17 5.4 0.3 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF745 PF05335.13 EFC42727.1 - 1.1 8.9 7.6 2.2 8.0 7.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Occludin_ELL PF07303.13 EFC42727.1 - 1.2 9.9 17.6 0.42 11.4 12.2 2.1 1 1 1 2 2 2 0 Occludin homology domain FapA PF03961.13 EFC42727.1 - 1.3 7.6 13.4 0.86 8.1 10.6 1.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A PRKG1_interact PF15898.5 EFC42727.1 - 1.3 9.9 11.1 4.4 8.3 10.9 1.9 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF148 PF02520.17 EFC42727.1 - 1.5 8.9 10.1 0.33 11.1 2.4 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 ArsA_ATPase PF02374.15 EFC42727.1 - 1.7 7.7 7.9 1.1 8.4 2.9 2.0 1 1 1 2 2 2 0 Anion-transporting ATPase DUF2207 PF09972.9 EFC42727.1 - 2 7.1 7.8 2.2 6.9 7.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) IFT57 PF10498.9 EFC42727.1 - 2.2 7.2 13.5 2.5 7.0 13.0 1.4 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 YgaB PF14182.6 EFC42727.1 - 2.2 8.7 12.3 2 8.9 5.6 2.8 1 1 2 3 3 3 0 YgaB-like protein Syntaxin PF00804.25 EFC42727.1 - 2.4 7.8 15.2 0.88 9.2 3.9 2.1 1 1 1 2 2 2 0 Syntaxin RPW8 PF05659.11 EFC42727.1 - 3.1 7.5 13.6 0.45 10.2 5.5 2.5 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 XhlA PF10779.9 EFC42727.1 - 3.5 7.9 11.4 1.5 9.1 1.1 3.0 1 1 2 3 3 3 0 Haemolysin XhlA TMPIT PF07851.13 EFC42727.1 - 4 6.6 14.7 6.6 5.9 14.7 1.4 1 1 0 1 1 1 0 TMPIT-like protein P4Ha_N PF08336.11 EFC42727.1 - 4.2 7.4 8.3 12 5.9 1.0 2.1 1 1 2 3 3 3 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Sigma70_ner PF04546.13 EFC42727.1 - 4.8 7.0 9.9 6.4 6.6 9.9 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region PilO PF04350.13 EFC42727.1 - 6 7.0 11.0 11 6.2 2.9 2.3 1 1 1 2 2 2 0 Pilus assembly protein, PilO Uso1_p115_C PF04871.13 EFC42727.1 - 7 7.0 11.8 65 3.9 11.8 2.0 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region ATP-synt_G PF04718.15 EFC42727.1 - 8 7.4 8.8 4.9 8.1 0.8 2.3 1 1 0 2 2 2 0 Mitochondrial ATP synthase g subunit Tup_N PF08581.10 EFC42727.1 - 8.5 6.8 9.9 6.2 7.2 0.9 2.4 2 0 0 2 2 2 0 Tup N-terminal Mgm101p PF06420.12 EFC42728.1 - 2.6e-72 241.9 0.0 4e-72 241.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Pkinase PF00069.25 EFC42729.1 - 1.2e-71 241.2 2.4 1.4e-68 231.1 2.4 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42729.1 - 2.2e-34 118.9 0.2 7.5e-34 117.2 0.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC42729.1 - 0.00045 19.6 0.1 0.002 17.5 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC42729.1 - 0.0036 16.3 0.4 0.0063 15.5 0.4 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC42729.1 - 0.0051 16.2 0.1 0.0078 15.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFC42730.1 - 5.4e-58 196.4 0.0 7.1e-58 196.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42730.1 - 4.5e-28 98.3 0.0 1.2e-27 96.8 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFC42730.1 - 3.5e-05 23.3 0.0 5e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFC42730.1 - 0.028 13.4 0.0 0.04 12.9 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC42730.1 - 0.088 11.6 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EFC42730.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFC42730.1 - 0.13 12.2 0.1 0.22 11.4 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Acyltransferase PF01553.21 EFC42731.1 - 6.7e-20 71.1 0.0 1.3e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EFC42731.1 - 1.5e-08 34.6 0.1 3e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 Acyltransferase C-terminus Aminotran_1_2 PF00155.21 EFC42732.1 - 3.3e-35 121.9 0.0 4.2e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFC42732.1 - 1.1e-05 24.1 0.0 1.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFC42732.1 - 2.6e-05 23.4 0.0 4.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFC42732.1 - 0.0003 20.2 0.0 0.00041 19.8 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 EFC42732.1 - 0.0049 16.2 0.0 0.007 15.7 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_3 PF00202.21 EFC42732.1 - 0.075 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III Peptidase_M19 PF01244.21 EFC42733.1 - 2.3e-56 191.3 0.2 2.8e-56 191.0 0.2 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Synaptobrevin PF00957.21 EFC42734.1 - 2.2e-11 43.4 0.1 4.1e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 Synaptobrevin rRNA_proc-arch PF13234.6 EFC42734.1 - 0.0011 19.0 0.2 0.0017 18.3 0.2 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain Longin PF13774.6 EFC42734.1 - 0.0028 17.6 0.0 0.0057 16.7 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain YlqD PF11068.8 EFC42734.1 - 0.021 15.2 0.5 0.038 14.4 0.5 1.3 1 0 0 1 1 1 0 YlqD protein Sybindin PF04099.12 EFC42734.1 - 0.026 14.5 0.1 0.04 13.8 0.1 1.4 1 0 0 1 1 1 0 Sybindin-like family DUF4208 PF13907.6 EFC42734.1 - 0.035 14.5 0.6 0.071 13.6 0.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Cytochrom_B562 PF07361.11 EFC42734.1 - 0.035 14.8 1.2 0.066 13.9 1.2 1.4 1 0 0 1 1 1 0 Cytochrome b562 Serine_rich PF08824.10 EFC42734.1 - 0.099 12.6 0.6 0.19 11.7 0.6 1.6 1 1 0 1 1 1 0 Serine rich protein interaction domain 2OG-FeII_Oxy_3 PF13640.6 EFC42735.1 - 1.2e-11 45.3 0.1 2.1e-11 44.5 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC42735.1 - 0.0081 16.6 0.0 0.019 15.5 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Peptidase_M30 PF10460.9 EFC42736.1 - 0.00013 21.0 0.5 0.00021 20.4 0.5 1.3 1 0 0 1 1 1 1 Peptidase M30 LRR_6 PF13516.6 EFC42737.1 - 3.4e-25 85.9 44.4 0.00079 19.3 0.1 15.0 17 0 0 17 17 17 9 Leucine Rich repeat LRR_4 PF12799.7 EFC42737.1 - 7.6e-18 64.3 49.9 0.0027 18.1 3.5 11.2 6 3 6 12 12 12 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC42737.1 - 1.1e-05 25.1 39.8 0.0034 17.1 2.9 9.4 7 4 3 10 10 10 4 Leucine rich repeat LRR_9 PF14580.6 EFC42737.1 - 2.3e-05 24.0 13.8 0.026 14.1 0.3 4.5 3 2 1 4 4 4 2 Leucine-rich repeat F-box-like PF12937.7 EFC42737.1 - 0.0053 16.6 0.2 0.011 15.6 0.2 1.5 1 0 0 1 1 1 1 F-box-like PB1 PF00564.24 EFC42737.1 - 0.068 13.1 0.0 0.27 11.2 0.0 2.0 1 0 0 1 1 1 0 PB1 domain LRR_1 PF00560.33 EFC42737.1 - 0.14 12.8 40.0 5 8.1 0.0 12.2 13 2 0 13 13 13 0 Leucine Rich Repeat Pesticin PF16754.5 EFC42738.1 - 3.8e-61 205.5 1.7 4.6e-61 205.2 0.7 1.6 2 0 0 2 2 2 1 Bacterial toxin homologue of phage lysozyme, C-term DUF512 PF04459.12 EFC42738.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF512) OmdA PF13376.6 EFC42738.1 - 7.9 6.6 6.5 0.55 10.3 0.1 2.4 3 0 0 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated ABC_tran PF00005.27 EFC42739.1 - 1.4e-28 100.1 0.0 3.2e-28 98.9 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 EFC42739.1 - 2e-26 92.9 30.2 3.1e-26 92.3 30.2 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 EFC42739.1 - 3.4e-08 33.7 0.0 0.00021 21.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC42739.1 - 0.01 15.7 0.1 0.024 14.6 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 EFC42739.1 - 0.026 13.9 0.0 9 5.7 0.1 2.4 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.17 EFC42739.1 - 0.03 14.1 0.0 9 6.0 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_15 PF13175.6 EFC42739.1 - 0.087 12.5 4.4 0.21 11.2 0.1 2.7 1 1 1 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EFC42739.1 - 0.089 12.5 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EFC42739.1 - 0.14 12.3 0.2 0.48 10.5 0.2 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EFC42739.1 - 0.18 12.3 3.3 0.15 12.5 0.4 2.3 2 1 0 2 2 2 0 AAA domain ABC2_membrane_2 PF12679.7 EFC42739.1 - 0.67 9.2 18.4 1.3 8.2 18.4 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF4116 PF13475.6 EFC42740.1 - 5.5e-73 240.5 21.9 1.4e-14 53.5 0.0 11.1 6 3 4 11 11 11 11 Domain of unknown function (DUF4116) UBA PF00627.31 EFC42740.1 - 0.098 12.6 0.9 2 8.4 0.0 3.4 3 0 0 3 3 3 0 UBA/TS-N domain Glyoxalase PF00903.25 EFC42741.1 - 7e-07 29.5 0.1 9e-05 22.7 0.0 2.4 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CppA_N PF14506.6 EFC42741.1 - 0.01 15.9 0.7 0.15 12.2 0.1 2.6 3 0 0 3 3 3 0 CppA N-terminal NHL PF01436.21 EFC42742.1 - 4.2e-47 155.9 33.9 0.00015 21.6 0.1 12.6 12 0 0 12 12 12 11 NHL repeat SGL PF08450.12 EFC42742.1 - 2.1e-08 34.1 4.8 8.9 5.8 0.1 6.9 7 2 0 7 7 7 2 SMP-30/Gluconolactonase/LRE-like region Linker_histone PF00538.19 EFC42742.1 - 3.7e-07 30.4 7.8 9.4 6.7 0.1 9.9 10 2 2 12 12 12 1 linker histone H1 and H5 family TRL PF13146.6 EFC42742.1 - 1.4e-05 25.3 11.8 6.7 7.1 0.0 8.8 9 0 0 9 9 9 1 TRL-like protein family KdpD PF02702.17 EFC42742.1 - 9.8e-05 21.9 0.0 19 4.7 0.0 6.7 8 0 0 8 8 8 0 Osmosensitive K+ channel His kinase sensor domain DUF2092 PF09865.9 EFC42742.1 - 0.00012 21.5 0.5 20 4.5 0.0 6.3 4 2 4 8 8 8 0 Predicted periplasmic protein (DUF2092) DUF1236 PF06823.12 EFC42742.1 - 0.00025 20.9 13.2 9.9 6.1 0.0 7.0 8 0 0 8 8 6 1 Protein of unknown function (DUF1236) YdfZ PF14001.6 EFC42742.1 - 0.0011 19.3 7.7 8 7.0 0.0 7.2 7 0 0 7 7 7 1 YdfZ protein NSs PF11073.8 EFC42742.1 - 0.0012 18.3 0.2 45 3.4 0.0 5.4 5 1 1 6 6 6 0 Rift valley fever virus non structural protein (NSs) like PsbX PF06596.11 EFC42742.1 - 0.0018 18.2 3.4 74 3.5 0.0 6.0 6 0 0 6 6 6 0 Photosystem II reaction centre X protein (PsbX) Phytase-like PF13449.6 EFC42742.1 - 0.011 15.8 1.6 9.3 6.1 0.0 5.5 6 3 0 6 6 6 0 Esterase-like activity of phytase Cytochrom_D1 PF02239.16 EFC42742.1 - 0.021 13.4 0.0 10 4.5 0.0 4.2 5 1 0 5 5 5 0 Cytochrome D1 heme domain tRNA_anti-codon PF01336.25 EFC42742.1 - 0.068 13.2 2.8 91 3.2 0.0 5.9 8 0 0 8 8 8 0 OB-fold nucleic acid binding domain MJ1316 PF04457.12 EFC42742.1 - 0.093 13.5 18.0 83 4.0 0.0 8.7 10 0 0 10 10 10 0 MJ1316 RNA cyclic group end recognition domain iPGM_N PF06415.13 EFC42742.1 - 0.79 9.1 3.3 4.4 6.7 0.1 3.3 4 0 0 4 4 4 0 BPG-independent PGAM N-terminus (iPGM_N) potato_inhibit PF00280.18 EFC42742.1 - 1.7 9.3 10.6 1.3e+02 3.3 0.1 6.4 8 0 0 8 8 6 0 Potato inhibitor I family PARG_cat PF05028.14 EFC42743.1 - 2.2e-12 46.9 0.0 2.7e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Trypan_PARP PF05887.11 EFC42745.1 - 1.7e-05 24.8 75.2 0.0073 16.3 37.1 2.1 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Trypan_PARP PF05887.11 EFC42746.1 - 0.00017 21.6 92.3 0.054 13.5 37.9 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) DUF1935 PF09149.10 EFC42748.1 - 0.061 13.7 1.3 1.3 9.4 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1935) HemY_N PF07219.13 EFC42748.1 - 9.2 6.5 8.7 15 5.9 0.2 2.4 2 0 0 2 2 2 0 HemY protein N-terminus DUF4116 PF13475.6 EFC42749.1 - 1.2e-106 348.3 30.3 8.6e-16 57.4 0.0 13.2 7 3 7 14 14 14 13 Domain of unknown function (DUF4116) DUF3860 PF12976.7 EFC42749.1 - 0.061 13.4 0.0 0.59 10.2 0.0 2.7 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3860) 3Beta_HSD PF01073.19 EFC42750.1 - 3.8e-15 55.6 0.0 5.9e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC42750.1 - 1.4e-11 44.3 0.0 3.4e-11 43.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFC42750.1 - 2.9e-10 39.8 0.0 4.4e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFC42750.1 - 7.3e-06 25.6 0.1 1.1e-05 25.0 0.1 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFC42750.1 - 0.0015 18.5 0.0 0.067 13.1 0.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC42750.1 - 0.0043 16.6 0.0 0.009 15.6 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family pPIWI_RE_REase PF18154.1 EFC42750.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 REase associating with pPIWI_RE RGS PF00615.19 EFC42751.1 - 3e-07 30.7 2.9 7.8e-07 29.4 2.9 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4577 PF15145.6 EFC42751.1 - 0.17 11.9 8.5 2.1 8.4 0.1 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4577) ArfGap PF01412.18 EFC42752.1 - 1.7e-16 60.3 1.1 1.7e-16 60.3 1.1 3.0 3 1 2 5 5 5 1 Putative GTPase activating protein for Arf NAAA-beta PF15508.6 EFC42753.1 - 1.1e-13 51.3 0.0 3e-13 49.9 0.0 1.8 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.18 EFC42753.1 - 1.9e-06 27.8 0.0 3.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family AAT PF03417.16 EFC42753.1 - 0.0096 15.6 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase ubiquitin PF00240.23 EFC42754.1 - 8e-07 28.7 0.0 2e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC42754.1 - 0.011 15.5 0.0 0.039 13.8 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFC42754.1 - 0.085 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like LRR_4 PF12799.7 EFC42754.1 - 0.59 10.6 5.1 6.8 7.3 4.3 2.9 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42754.1 - 1.3 9.9 4.6 35 5.5 0.3 3.9 3 1 0 3 3 3 0 Leucine Rich Repeat ubiquitin PF00240.23 EFC42755.1 - 7.4e-37 124.9 7.9 7.6e-22 76.9 1.6 2.1 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC42755.1 - 2.4e-12 46.5 8.6 2.7e-07 30.3 1.6 2.1 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Diphtheria_C PF02763.14 EFC42755.1 - 0.011 15.5 0.1 0.014 15.1 0.1 1.1 1 0 0 1 1 1 0 Diphtheria toxin, C domain ALAD PF00490.21 EFC42755.1 - 0.016 14.4 0.0 0.022 13.9 0.0 1.1 1 0 0 1 1 1 0 Delta-aminolevulinic acid dehydratase TBK1_ULD PF18396.1 EFC42755.1 - 0.025 14.5 0.4 0.068 13.1 0.0 1.8 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain PDGLE PF13190.6 EFC42755.1 - 0.026 14.4 0.1 1.2 9.0 0.1 2.7 1 1 1 2 2 2 0 PDGLE domain Ubiquitin_2 PF14560.6 EFC42755.1 - 0.038 14.4 3.4 3.1 8.3 0.1 3.1 2 1 0 2 2 2 0 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC42755.1 - 0.058 13.5 5.9 13 5.9 0.1 3.4 2 2 2 4 4 4 0 Ubiquitin-like domain Aldedh PF00171.22 EFC42757.1 - 2.6e-156 520.7 0.1 3e-156 520.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 EFC42757.1 - 5.9e-06 25.6 0.0 9.9e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 EFC42757.1 - 0.00034 20.2 0.1 0.0018 17.7 0.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) IgG_binding_B PF01378.17 EFC42757.1 - 0.86 9.7 3.4 15 5.7 0.1 3.5 4 0 0 4 4 4 0 B domain Lipase_3 PF01764.25 EFC42758.1 - 8.1e-06 25.8 0.0 3e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 EFC42758.1 - 0.0028 17.4 0.2 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 PGAP1-like protein DUF2974 PF11187.8 EFC42758.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) FA_desaturase PF00487.24 EFC42758.1 - 0.13 12.0 0.1 0.13 12.0 0.1 3.6 3 1 1 4 4 4 0 Fatty acid desaturase Hydrolase_4 PF12146.8 EFC42758.1 - 0.18 11.1 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 EFC42758.1 - 0.2 11.6 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) TPPK_C PF12555.8 EFC42758.1 - 0.27 11.3 3.4 1.2 9.2 3.4 2.2 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal RGS PF00615.19 EFC42759.1 - 0.00038 20.7 11.2 0.0041 17.4 1.0 3.1 4 0 0 4 4 4 2 Regulator of G protein signaling domain DUF4116 PF13475.6 EFC42761.1 - 1e-27 95.6 32.0 2.5e-07 30.3 0.5 8.8 2 2 5 8 8 8 8 Domain of unknown function (DUF4116) AAA_18 PF13238.6 EFC42762.1 - 0.00013 22.5 1.9 0.0085 16.6 0.0 3.4 2 1 1 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 EFC42762.1 - 0.00022 21.3 0.0 0.00084 19.4 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase T2SSE PF00437.20 EFC42762.1 - 0.00033 19.8 0.3 0.00065 18.8 0.3 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 EFC42762.1 - 0.00064 19.8 1.1 0.0071 16.4 0.0 3.0 3 1 0 3 3 3 1 AAA domain KTI12 PF08433.10 EFC42762.1 - 0.0013 18.3 0.0 0.0032 17.0 0.0 1.7 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 EFC42762.1 - 0.0018 18.7 0.0 0.013 15.9 0.0 2.3 2 1 0 3 3 2 1 AAA ATPase domain AAA PF00004.29 EFC42762.1 - 0.0028 18.1 0.1 0.028 14.9 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 EFC42762.1 - 0.0064 16.5 0.3 0.35 10.9 0.1 2.7 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.15 EFC42762.1 - 0.0075 16.2 1.1 1.6 8.6 0.0 3.2 3 0 0 3 3 3 1 NTPase AAA_33 PF13671.6 EFC42762.1 - 0.0088 16.2 0.0 0.023 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain PIF1 PF05970.14 EFC42762.1 - 0.011 14.9 0.0 0.034 13.3 0.0 1.8 2 0 0 2 2 2 0 PIF1-like helicase AAA_22 PF13401.6 EFC42762.1 - 0.011 16.0 0.1 0.064 13.5 0.0 2.2 2 1 0 2 2 1 0 AAA domain TniB PF05621.11 EFC42762.1 - 0.011 15.1 0.0 1.9 7.9 0.0 2.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 EFC42762.1 - 0.012 15.3 0.0 0.041 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFC42762.1 - 0.014 15.0 0.0 1.4 8.5 0.0 2.7 2 1 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 EFC42762.1 - 0.02 14.2 0.0 0.041 13.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 EFC42762.1 - 0.02 14.6 0.0 0.04 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC42762.1 - 0.022 14.5 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TK PF00265.18 EFC42762.1 - 0.022 14.6 0.0 0.087 12.7 0.0 2.0 2 0 0 2 2 2 0 Thymidine kinase FeoB_N PF02421.18 EFC42762.1 - 0.031 13.8 0.4 0.28 10.7 0.0 2.7 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_5 PF07728.14 EFC42762.1 - 0.04 13.9 0.0 0.32 11.0 0.0 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 EFC42762.1 - 0.044 13.5 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EFC42762.1 - 0.047 13.2 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 EFC42762.1 - 0.051 12.5 0.1 0.15 11.0 0.0 1.7 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ABC_tran PF00005.27 EFC42762.1 - 0.051 14.1 0.3 0.82 10.2 0.0 2.6 3 1 0 4 4 3 0 ABC transporter MeaB PF03308.16 EFC42762.1 - 0.053 12.5 0.0 0.12 11.3 0.0 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 EFC42762.1 - 0.058 12.7 0.0 0.14 11.5 0.0 1.7 1 1 1 2 2 2 0 FtsK/SpoIIIE family TMCCDC2 PF15844.5 EFC42762.1 - 0.066 13.1 8.1 0.51 10.2 2.2 2.6 2 0 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 RNA_helicase PF00910.22 EFC42762.1 - 0.09 13.2 0.0 0.65 10.4 0.0 2.6 3 1 0 3 3 1 0 RNA helicase Mg_chelatase PF01078.21 EFC42762.1 - 0.092 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI E1-E2_ATPase PF00122.20 EFC42763.1 - 3.8e-21 75.4 0.7 4.8e-21 75.1 0.7 1.1 1 0 0 1 1 1 1 E1-E2 ATPase DUF1137 PF06587.11 EFC42763.1 - 0.018 15.0 0.0 0.046 13.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1137) Stomoxyn PF11585.8 EFC42763.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn Cation_ATPase_N PF00690.26 EFC42763.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Syntaxin-18_N PF10496.9 EFC42764.1 - 0.053 13.8 2.3 0.22 11.8 0.3 2.7 2 1 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus LPP PF04728.13 EFC42764.1 - 0.82 10.1 2.9 22 5.6 0.3 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Exonuc_VII_L PF02601.15 EFC42764.1 - 6.9 6.1 12.1 12 5.4 12.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 EFC42764.1 - 9.6 6.3 16.2 1.2 9.1 6.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Microtub_bd PF16796.5 EFC42765.1 - 0.0026 17.7 2.1 0.0047 16.9 0.6 1.9 1 1 1 2 2 2 1 Microtubule binding Bud13 PF09736.9 EFC42765.1 - 0.17 12.3 10.7 0.059 13.8 7.6 1.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex CHD5 PF04420.14 EFC42765.1 - 2 8.2 7.5 3.6 7.4 7.5 1.4 1 1 0 1 1 1 0 CHD5-like protein DUF4116 PF13475.6 EFC42766.1 - 3.2e-50 167.6 23.9 4.2e-10 39.2 0.1 11.3 6 4 3 10 10 10 10 Domain of unknown function (DUF4116) Hemocyanin_N PF03722.14 EFC42766.1 - 0.15 12.5 1.1 4.2 7.9 1.0 2.9 2 0 0 2 2 2 0 Hemocyanin, all-alpha domain F-box-like PF12937.7 EFC42767.1 - 2.8e-07 30.3 0.1 6.8e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC42767.1 - 5e-05 23.1 0.1 0.00013 21.7 0.1 1.8 1 0 0 1 1 1 1 F-box domain DUF1963 PF09234.10 EFC42767.1 - 0.1 13.1 1.9 0.34 11.3 1.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1963) DUF4116 PF13475.6 EFC42768.1 - 1.8e-50 168.4 42.1 4e-11 42.5 0.4 8.1 5 3 4 9 9 9 8 Domain of unknown function (DUF4116) CNOT11 PF10155.9 EFC42768.1 - 2.9 8.1 7.0 0.84 9.8 0.4 3.1 4 0 0 4 4 4 0 CCR4-NOT transcription complex subunit 11 Glyco_transf_10 PF00852.19 EFC42769.1 - 8.2e-25 87.5 0.1 1.5e-24 86.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term MACPF PF01823.19 EFC42770.1 - 1e-08 35.6 0.2 2e-08 34.6 0.2 1.5 1 1 0 1 1 1 1 MAC/Perforin domain DUF4587 PF15248.6 EFC42771.1 - 2.5 9.0 6.7 8.1 7.3 1.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4587) Dmd PF17587.2 EFC42773.1 - 0.048 14.0 0.3 0.12 12.7 0.3 1.7 1 0 0 1 1 1 0 Discriminator of mRNA degradation Zn_clus PF00172.18 EFC42773.1 - 0.25 11.5 4.7 0.093 12.9 1.7 1.9 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 EFC42774.1 - 3e-19 69.5 0.0 5.2e-19 68.7 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC42774.1 - 7e-14 51.8 0.4 5.4e-07 29.1 0.0 1.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC42774.1 - 1e-11 45.0 0.0 2.4e-06 27.4 0.0 2.4 3 0 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 EFC42774.1 - 1.1e-08 34.6 0.0 1.9e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EFC42774.1 - 1.8e-07 31.2 0.0 3.9e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EFC42774.1 - 8.5e-06 24.9 0.0 0.065 12.1 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 EFC42774.1 - 6.6e-05 23.4 0.0 0.00023 21.7 0.0 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC42774.1 - 0.00012 21.3 0.0 0.0015 17.7 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 EFC42774.1 - 0.0002 20.2 0.0 0.00031 19.6 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein GIDA PF01134.22 EFC42774.1 - 0.0014 17.8 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EFC42774.1 - 0.0028 17.0 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC42774.1 - 0.0053 15.9 0.0 1.6 7.7 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.7 EFC42774.1 - 0.01 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 EFC42774.1 - 0.083 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 EFC42774.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EFC42774.1 - 0.16 12.4 0.0 0.41 11.1 0.0 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding F-box PF00646.33 EFC42775.1 - 0.06 13.2 4.4 0.24 11.3 4.4 2.1 1 1 0 1 1 1 0 F-box domain IQ PF00612.27 EFC42776.1 - 7.5e-06 25.3 1.4 1.7e-05 24.2 1.4 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif FHA PF00498.26 EFC42777.1 - 5.2e-06 26.7 0.2 1.2e-05 25.5 0.2 1.7 1 0 0 1 1 1 1 FHA domain Alpha-amylase PF00128.24 EFC42778.1 - 1.2e-13 51.3 0.1 2.7e-07 30.5 0.1 2.3 2 0 0 2 2 2 2 Alpha amylase, catalytic domain Viral_Hsp90 PF03225.14 EFC42778.1 - 0.058 11.9 0.1 0.1 11.1 0.1 1.3 1 0 0 1 1 1 0 Viral heat shock protein Hsp90 homologue E1-E2_ATPase PF00122.20 EFC42779.1 - 5.6e-15 55.3 0.0 7.8e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase Pkinase PF00069.25 EFC42780.1 - 1.3e-60 205.0 1.6 2.4e-59 200.8 1.6 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42780.1 - 9.3e-29 100.5 4.2 3.9e-27 95.2 0.5 3.6 2 1 0 2 2 2 1 Protein tyrosine kinase tRNA-synt_His PF13393.6 EFC42780.1 - 9.1e-16 58.0 0.0 4.9e-15 55.6 0.0 2.0 2 0 0 2 2 2 1 Histidyl-tRNA synthetase RWD PF05773.22 EFC42780.1 - 8.2e-05 22.9 1.8 8.2e-05 22.9 1.8 3.4 3 0 0 3 3 3 1 RWD domain HGTP_anticodon PF03129.20 EFC42780.1 - 0.00018 21.6 0.0 0.00094 19.3 0.0 2.3 1 0 0 1 1 1 1 Anticodon binding domain Vac14_Fab1_bd PF12755.7 EFC42781.1 - 1.1e-13 51.6 2.8 0.0049 17.4 0.0 6.9 6 1 1 7 7 7 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFC42781.1 - 1e-12 48.3 0.2 0.0011 19.5 0.4 8.6 8 2 2 10 10 9 2 HEAT-like repeat HEAT PF02985.22 EFC42781.1 - 2.8e-11 42.6 5.2 0.12 12.7 0.0 8.0 9 0 0 9 9 8 3 HEAT repeat ParcG PF10274.9 EFC42781.1 - 1.9e-09 37.9 5.7 0.0073 16.4 0.0 6.7 5 3 3 8 8 8 3 Parkin co-regulated protein Cnd1 PF12717.7 EFC42781.1 - 2.1e-09 37.6 4.9 0.039 14.0 0.0 5.9 4 2 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC42781.1 - 1e-08 35.4 0.0 7.3 7.1 0.0 6.8 4 4 4 8 8 8 1 HEAT repeats IBN_N PF03810.19 EFC42781.1 - 4e-07 29.8 0.2 4e-07 29.8 0.2 3.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain UME PF08064.13 EFC42781.1 - 1.9e-06 27.7 7.1 1.2 9.1 0.0 7.5 5 3 2 7 7 7 2 UME (NUC010) domain RTP1_C1 PF10363.9 EFC42781.1 - 2e-06 27.9 0.4 0.028 14.6 0.0 4.6 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_N PF14500.6 EFC42781.1 - 9.4e-06 25.4 2.8 0.18 11.4 0.0 5.3 6 0 0 6 6 6 1 Dos2-interacting transcription regulator of RNA-Pol-II Ipi1_N PF12333.8 EFC42781.1 - 9.7e-06 26.1 0.2 1.4 9.6 0.0 4.3 4 0 0 4 4 4 2 Rix1 complex component involved in 60S ribosome maturation DUF3385 PF11865.8 EFC42781.1 - 1.1e-05 25.4 11.7 3.6 7.5 0.1 7.5 5 2 2 7 7 7 2 Domain of unknown function (DUF3385) RIX1 PF08167.12 EFC42781.1 - 1.9e-05 24.5 0.7 0.44 10.3 0.1 4.4 6 0 0 6 6 5 2 rRNA processing/ribosome biogenesis IFRD PF05004.13 EFC42781.1 - 3.8e-05 22.9 0.2 1.5 7.8 0.0 4.4 4 2 0 4 4 4 2 Interferon-related developmental regulator (IFRD) Tti2 PF10521.9 EFC42781.1 - 0.0016 18.0 2.3 0.22 11.0 0.0 3.7 4 0 0 4 4 4 1 Tti2 family DNA_alkylation PF08713.11 EFC42781.1 - 0.031 14.0 0.1 0.24 11.1 0.0 2.6 2 1 0 2 2 2 0 DNA alkylation repair enzyme Importin_rep_5 PF18816.1 EFC42781.1 - 0.033 14.5 0.2 1.5 9.2 0.0 3.9 5 0 0 5 5 3 0 Importin repeat Cohesin_HEAT PF12765.7 EFC42781.1 - 0.081 13.2 0.0 18 5.8 0.0 3.2 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion PUL PF08324.11 EFC42781.1 - 0.1 11.8 8.8 0.14 11.4 0.1 3.5 4 0 0 4 4 4 0 PUL domain Trigger_C PF05698.14 EFC42781.1 - 2.9 7.9 7.5 15 5.6 0.6 2.9 2 0 0 2 2 2 0 Bacterial trigger factor protein (TF) C-terminus RIH_assoc PF08454.11 EFC42781.1 - 5.8 6.8 9.1 1.3 8.9 0.3 3.9 4 1 0 4 4 4 0 RyR and IP3R Homology associated Ribosomal_60s PF00428.19 EFC42781.1 - 8.4 7.1 6.0 52 4.5 0.1 2.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Kelch_6 PF13964.6 EFC42782.1 - 7.2e-16 57.8 1.3 1.2e-07 31.8 0.1 3.1 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.6 EFC42782.1 - 3.6e-15 55.8 0.1 1.5e-06 28.3 0.1 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC42782.1 - 1e-14 54.2 6.9 3.7e-07 30.1 0.1 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC42782.1 - 7.4e-13 47.9 1.2 1.3e-05 24.7 0.2 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EFC42782.1 - 5.4e-11 42.0 0.8 0.00024 20.9 0.0 3.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 EFC42782.1 - 7.7e-09 35.3 3.4 1.2e-05 25.2 0.1 3.1 3 0 0 3 3 3 2 Kelch motif MACPF PF01823.19 EFC42783.1 - 8.7e-05 22.7 0.1 0.0012 19.0 0.1 2.3 1 1 0 1 1 1 1 MAC/Perforin domain DUF3614 PF12267.8 EFC42783.1 - 0.12 12.9 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3614) Peptidase_M76 PF09768.9 EFC42784.1 - 4.2e-27 95.0 1.0 8.7e-27 94.0 1.0 1.6 1 0 0 1 1 1 1 Peptidase M76 family DUF2268 PF10026.9 EFC42784.1 - 0.01 15.4 0.0 0.021 14.4 0.0 1.5 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) DUF5034 PF16437.5 EFC42784.1 - 0.072 13.1 0.1 0.29 11.1 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5034) Pal1 PF08316.11 EFC42784.1 - 0.083 13.6 1.7 0.23 12.2 1.7 1.7 1 0 0 1 1 1 0 Pal1 cell morphology protein DUF4820 PF16091.5 EFC42784.1 - 1 8.7 6.7 2.1 7.6 6.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Snf7 PF03357.21 EFC42785.1 - 4.1e-28 98.1 18.2 4.1e-28 98.1 18.2 1.9 2 0 0 2 2 2 1 Snf7 HHH_5 PF14520.6 EFC42785.1 - 0.028 15.0 0.3 0.089 13.4 0.1 1.9 2 0 0 2 2 2 0 Helix-hairpin-helix domain LuxC PF05893.14 EFC42785.1 - 0.04 13.0 1.0 0.046 12.8 1.0 1.1 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1428 PF07237.11 EFC42785.1 - 0.085 13.1 0.4 0.14 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1428) DUF948 PF06103.11 EFC42785.1 - 0.15 12.4 2.5 0.16 12.3 1.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) COMM_domain PF07258.14 EFC42786.1 - 1.2e-15 57.3 0.0 2.4e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 COMM domain Pkinase PF00069.25 EFC42787.1 - 9e-71 238.3 0.0 1.1e-70 238.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42787.1 - 2.9e-34 118.5 0.0 4.6e-34 117.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC42787.1 - 7.4e-06 25.5 0.1 0.00012 21.6 0.0 2.4 1 1 1 2 2 2 1 Kinase-like EF-G-binding_N PF07299.11 EFC42787.1 - 0.0011 19.5 2.8 0.47 11.0 0.1 3.1 3 0 0 3 3 3 2 Elongation factor G-binding protein, N-terminal Haspin_kinase PF12330.8 EFC42787.1 - 0.0013 17.7 3.0 0.0039 16.2 3.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC42787.1 - 0.0014 17.5 0.1 0.0045 15.8 0.0 1.7 1 1 1 2 2 2 1 Fungal protein kinase ASXH PF13919.6 EFC42787.1 - 0.012 15.6 2.1 0.012 15.6 0.6 1.8 2 0 0 2 2 2 0 Asx homology domain Kdo PF06293.14 EFC42787.1 - 0.024 14.0 2.9 0.049 13.0 2.9 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC42787.1 - 0.046 13.6 0.1 2.8 7.8 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family Coat_F PF07875.12 EFC42787.1 - 0.059 13.6 0.9 0.26 11.5 0.1 2.3 3 0 0 3 3 3 0 Coat F domain UPF0181 PF03701.14 EFC42788.1 - 0.0047 16.5 0.1 0.017 14.8 0.1 1.9 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0181) PfaD_N PF18328.1 EFC42788.1 - 0.023 14.6 0.0 0.06 13.3 0.0 1.7 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain DUF4476 PF14771.6 EFC42789.1 - 1e-23 83.4 1.5 1.7e-20 73.1 0.7 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4476) Nudix_N PF12535.8 EFC42789.1 - 0.091 12.4 0.0 1.6 8.4 0.1 2.2 2 0 0 2 2 2 0 Hydrolase of X-linked nucleoside diphosphate N terminal Extensin_2 PF04554.13 EFC42789.1 - 4.2 7.5 11.7 6.5 6.9 11.7 1.3 1 0 0 1 1 1 0 Extensin-like region TIMELESS_C PF05029.13 EFC42790.1 - 0.14 11.3 0.3 0.18 10.9 0.3 1.2 1 0 0 1 1 1 0 Timeless protein C terminal region DUF4829 PF16111.5 EFC42790.1 - 0.16 12.8 3.8 1.1 10.0 3.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4829) Na_sulph_symp PF00939.19 EFC42791.1 - 8.4e-74 249.3 17.5 2.8e-73 247.6 17.4 1.6 1 1 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EFC42791.1 - 2.4e-42 145.2 22.0 8.5e-35 120.4 1.9 3.1 1 1 1 2 2 2 2 Citrate transporter DUF4306 PF14154.6 EFC42791.1 - 0.045 13.9 6.3 0.041 14.0 3.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4306) DUF3810 PF12725.7 EFC42791.1 - 0.074 12.4 8.1 0.02 14.2 4.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) UPF0182 PF03699.13 EFC42791.1 - 0.075 11.2 3.6 0.15 10.1 3.6 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Orf78 PF06024.12 EFC42791.1 - 0.99 9.7 4.9 6.9 7.0 0.1 3.2 3 0 0 3 3 3 0 Orf78 (ac78) F-box-like PF12937.7 EFC42792.1 - 0.02 14.8 0.1 0.042 13.7 0.1 1.5 1 0 0 1 1 1 0 F-box-like Pkinase PF00069.25 EFC42793.1 - 1.3e-38 132.9 0.1 1.9e-38 132.3 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42793.1 - 4.3e-24 85.2 0.2 1e-23 84.0 0.2 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC42793.1 - 3.2e-08 32.8 0.1 4.3e-08 32.4 0.1 1.3 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC42793.1 - 6e-05 22.5 0.0 8.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC42793.1 - 0.0011 19.0 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC42793.1 - 0.01 14.9 0.0 0.02 13.9 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 EFC42793.1 - 0.03 13.9 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 RIO1 family PFU PF09070.11 EFC42794.1 - 2.2e-35 121.3 0.7 4.8e-35 120.2 0.7 1.6 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 EFC42794.1 - 2.6e-28 97.7 19.5 2.4e-05 25.0 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat PUL PF08324.11 EFC42794.1 - 5e-07 29.2 0.1 1e-06 28.2 0.1 1.4 1 0 0 1 1 1 1 PUL domain BBS2_Mid PF14783.6 EFC42794.1 - 2.5e-06 27.5 0.0 0.42 10.7 0.0 4.1 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EFC42794.1 - 0.024 14.0 0.0 0.051 12.9 0.0 1.6 1 1 0 1 1 1 0 WD40-like domain ResIII PF04851.15 EFC42795.1 - 9.3e-16 58.3 4.9 4.2e-15 56.2 2.3 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFC42795.1 - 2e-07 31.0 0.2 5.2e-07 29.6 0.2 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC42795.1 - 7.4e-07 29.5 0.1 3e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DNA_pol3_tau_5 PF12170.8 EFC42795.1 - 0.081 13.0 0.5 0.35 10.9 0.1 2.1 2 0 0 2 2 2 0 DNA polymerase III tau subunit V interacting with alpha Occludin_ELL PF07303.13 EFC42795.1 - 0.082 13.6 1.4 7.2 7.4 0.1 2.9 3 0 0 3 3 3 0 Occludin homology domain Helicase_C_2 PF13307.6 EFC42795.1 - 0.13 12.4 1.7 5.2 7.2 0.2 2.9 1 1 1 2 2 2 0 Helicase C-terminal domain RnlB_antitoxin PF15933.5 EFC42795.1 - 0.14 12.5 3.1 0.6 10.4 0.2 3.3 3 0 0 3 3 3 0 Antitoxin to bacterial toxin RNase LS or RnlA RasGEF PF00617.19 EFC42796.1 - 1.5e-45 155.6 3.4 1.5e-45 155.6 3.4 2.1 2 0 0 2 2 2 1 RasGEF domain DOCK-C2 PF14429.6 EFC42796.1 - 2.7e-33 115.4 2.1 9.5e-33 113.7 2.1 2.1 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC42796.1 - 3.5e-11 43.3 0.9 5.1e-10 39.5 0.9 3.2 1 0 0 1 1 1 1 RasGEF N-terminal motif CYYR1 PF10873.8 EFC42796.1 - 5.1 7.5 7.1 13 6.2 7.1 1.6 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 PEPCK_ATP PF01293.20 EFC42797.1 - 8.4e-12 44.5 0.4 3.6e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 Phosphoenolpyruvate carboxykinase Kelch_4 PF13418.6 EFC42799.1 - 6.8e-16 58.0 2.9 0.0062 16.5 0.0 5.5 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC42799.1 - 6.2e-13 48.4 2.1 0.088 12.8 0.2 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_3 PF13415.6 EFC42799.1 - 1.3e-10 41.3 0.7 0.00024 21.3 0.0 5.7 7 0 0 7 7 7 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC42799.1 - 1.4e-09 37.9 9.0 0.0064 16.7 0.3 6.4 6 2 2 8 8 8 2 Kelch motif Kelch_2 PF07646.15 EFC42799.1 - 5e-06 26.3 7.4 0.079 13.0 0.2 6.1 7 0 0 7 7 7 2 Kelch motif Kelch_1 PF01344.25 EFC42799.1 - 0.0011 18.5 7.1 0.031 13.9 0.1 3.9 5 0 0 5 5 5 2 Kelch motif AMP_N PF05195.16 EFC42799.1 - 0.096 12.4 0.1 20 4.9 0.0 2.6 2 0 0 2 2 2 0 Aminopeptidase P, N-terminal domain Arginase PF00491.21 EFC42800.1 - 6e-17 62.0 0.1 1.7e-16 60.5 0.1 1.7 1 1 0 1 1 1 1 Arginase family F-box PF00646.33 EFC42801.1 - 0.022 14.6 1.1 0.057 13.3 0.2 2.1 2 0 0 2 2 2 0 F-box domain PX PF00787.24 EFC42802.1 - 8.9e-11 41.8 0.7 3.2e-10 40.0 0.3 2.2 2 0 0 2 2 2 1 PX domain DUF4796 PF16044.5 EFC42802.1 - 0.071 12.7 2.9 0.51 9.9 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4796) PRESAN PF09687.10 EFC42802.1 - 0.27 11.8 4.7 0.14 12.7 0.8 2.5 2 0 0 2 2 2 0 Plasmodium RESA N-terminal NHL PF01436.21 EFC42803.1 - 2.2e-63 207.3 1.9 8.1e-06 25.6 0.0 12.9 12 0 0 12 12 12 11 NHL repeat Pkinase PF00069.25 EFC42803.1 - 1.5e-49 168.7 2.5 1.5e-49 168.7 2.5 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42803.1 - 1.4e-35 122.8 0.4 1.9e-35 122.4 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC42803.1 - 4.4e-06 25.7 0.1 6.9e-06 25.1 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF839 PF05787.13 EFC42803.1 - 0.00021 20.6 11.0 1.6 7.8 0.7 5.8 2 2 3 5 5 5 3 Bacterial protein of unknown function (DUF839) TMEM154 PF15102.6 EFC42803.1 - 0.0018 18.2 0.1 0.0038 17.1 0.1 1.6 1 0 0 1 1 1 1 TMEM154 protein family Shisa PF13908.6 EFC42803.1 - 0.0023 18.2 2.6 0.0045 17.2 2.6 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FrhB_FdhB_N PF04422.13 EFC42803.1 - 0.012 15.8 1.0 21 5.4 0.1 4.1 3 1 1 4 4 3 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term Phytase-like PF13449.6 EFC42803.1 - 0.022 14.7 0.7 78 3.1 0.0 5.6 5 1 2 7 7 7 0 Esterase-like activity of phytase TMEM132D_C PF15706.5 EFC42803.1 - 0.023 14.5 0.1 0.051 13.4 0.1 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term TMEM51 PF15345.6 EFC42803.1 - 0.076 12.8 0.4 0.14 12.0 0.4 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Pkinase PF00069.25 EFC42804.1 - 4.6e-62 209.8 0.0 4.6e-62 209.8 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42804.1 - 2.3e-32 112.3 0.0 5.9e-32 111.0 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC42804.1 - 0.012 15.5 0.1 0.046 13.6 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF4028 PF13220.6 EFC42804.1 - 0.31 10.9 0.1 0.31 10.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) Haspin_kinase PF12330.8 EFC42804.1 - 2.7 6.8 17.4 0.0065 15.5 6.3 2.2 2 1 0 2 2 2 0 Haspin like kinase domain Sec6 PF06046.13 EFC42805.1 - 1.4e-36 126.1 14.4 7.3e-19 67.6 1.5 3.3 3 0 0 3 3 3 2 Exocyst complex component Sec6 Xpo1 PF08389.12 EFC42805.1 - 1.1e-32 113.2 1.9 1.1e-32 113.2 1.9 4.5 4 0 0 4 4 4 1 Exportin 1-like protein TMF_TATA_bd PF12325.8 EFC42805.1 - 0.019 15.2 4.9 0.089 13.0 4.9 2.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HEAT PF02985.22 EFC42805.1 - 0.041 14.2 0.4 51 4.5 0.0 5.1 5 0 0 5 5 5 0 HEAT repeat Sec20 PF03908.13 EFC42805.1 - 0.13 12.2 4.5 9.3 6.3 1.5 4.1 3 0 0 3 3 3 0 Sec20 DUF2052 PF09747.9 EFC42805.1 - 0.38 10.9 5.7 0.57 10.3 1.0 2.5 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DcpS PF05652.12 EFC42806.1 - 1.9e-09 38.3 0.0 2.1e-09 38.2 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal AAA_6 PF12774.7 EFC42807.1 - 1.1e-127 425.5 1.9 1.8e-126 421.6 0.0 3.8 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC42807.1 - 6.3e-100 335.1 13.5 6.3e-100 335.1 13.5 6.2 6 1 0 6 6 4 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 EFC42807.1 - 1.2e-72 243.6 6.2 1.2e-72 243.6 6.2 5.0 5 0 0 5 5 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 EFC42807.1 - 2.7e-43 148.2 0.7 2.7e-43 148.2 0.7 3.8 4 0 0 4 4 4 1 P-loop containing dynein motor region D4 AAA_lid_11 PF18198.1 EFC42807.1 - 5.3e-40 136.9 0.1 1.4e-39 135.5 0.1 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC42807.1 - 4.4e-34 117.1 0.1 4.4e-34 117.1 0.1 4.2 6 0 0 6 6 1 1 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 EFC42807.1 - 8.5e-31 106.9 2.1 1.6e-25 89.7 0.0 4.4 4 0 0 4 4 4 2 P-loop containing dynein motor region DHC_N1 PF08385.12 EFC42807.1 - 1.5e-29 103.1 13.7 1.5e-29 103.1 13.7 4.1 5 0 0 5 5 4 1 Dynein heavy chain, N-terminal region 1 AAA_5 PF07728.14 EFC42807.1 - 2.9e-29 101.8 0.2 2.6e-19 69.6 0.0 6.3 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) MT PF12777.7 EFC42807.1 - 4.8e-27 94.9 13.2 4.8e-27 94.9 13.2 1.9 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 EFC42807.1 - 2.1e-23 83.0 0.1 2.1e-23 83.0 0.1 3.8 4 0 0 4 4 3 1 Dynein heavy chain C-terminal domain AAA PF00004.29 EFC42807.1 - 7.1e-11 42.7 1.7 0.0061 17.0 0.0 6.0 6 0 0 6 6 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC42807.1 - 4.2e-09 37.0 0.0 0.04 14.3 0.0 6.0 5 0 0 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 EFC42807.1 - 8.1e-05 22.9 11.7 0.47 10.7 0.0 6.3 6 0 0 6 6 4 2 AAA domain AAA_18 PF13238.6 EFC42807.1 - 0.00014 22.4 0.2 0.097 13.2 0.0 4.9 4 0 0 4 4 4 1 AAA domain AAA_19 PF13245.6 EFC42807.1 - 0.00019 21.8 0.8 3 8.2 0.0 4.5 4 0 0 4 4 3 1 AAA domain AAA_lid_1 PF17857.1 EFC42807.1 - 0.00035 20.7 0.7 0.0022 18.2 0.1 2.8 2 0 0 2 2 2 1 AAA+ lid domain AAA_24 PF13479.6 EFC42807.1 - 0.00095 18.9 6.5 0.1 12.3 0.0 4.9 6 0 0 6 6 4 1 AAA domain AAA_30 PF13604.6 EFC42807.1 - 0.001 18.8 1.2 0.29 10.8 0.0 3.4 4 0 0 4 4 3 1 AAA domain RNA_helicase PF00910.22 EFC42807.1 - 0.0024 18.2 0.0 0.88 10.0 0.0 3.9 3 0 0 3 3 3 1 RNA helicase ERM PF00769.19 EFC42807.1 - 0.0029 17.5 5.5 0.0029 17.5 5.5 6.0 5 2 1 6 6 5 1 Ezrin/radixin/moesin family RsgA_GTPase PF03193.16 EFC42807.1 - 0.003 17.5 5.0 1.3 8.9 0.0 4.2 4 0 0 4 4 3 2 RsgA GTPase NACHT PF05729.12 EFC42807.1 - 0.0057 16.6 0.2 1.3 8.9 0.0 3.3 3 0 0 3 3 2 1 NACHT domain ABC_tran PF00005.27 EFC42807.1 - 0.014 15.9 13.4 0.032 14.7 0.0 5.7 5 0 0 5 5 3 0 ABC transporter AAA_33 PF13671.6 EFC42807.1 - 0.018 15.2 0.5 1.1 9.5 0.0 3.9 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 EFC42807.1 - 0.021 14.5 0.0 13 5.4 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein cobW PF02492.19 EFC42807.1 - 0.026 14.1 0.2 5.1 6.7 0.0 2.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EFC42807.1 - 0.03 14.1 2.2 0.41 10.4 0.0 3.3 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein T2SSE PF00437.20 EFC42807.1 - 0.031 13.4 0.0 0.28 10.2 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_25 PF13481.6 EFC42807.1 - 0.042 13.4 0.6 2 7.9 0.0 3.1 4 0 0 4 4 2 0 AAA domain AAA_29 PF13555.6 EFC42807.1 - 0.048 13.4 0.0 0.95 9.3 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain TsaE PF02367.17 EFC42807.1 - 0.14 12.2 2.6 2 8.4 0.0 3.9 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 EFC42807.1 - 0.17 12.1 0.0 11 6.2 0.0 3.3 3 0 0 3 3 3 0 AAA domain PUF PF00806.19 EFC42808.1 - 6.6e-08 31.8 1.0 0.005 16.5 0.0 5.8 5 0 0 5 5 5 2 Pumilio-family RNA binding repeat Peptidase_M24 PF00557.24 EFC42809.1 - 4.5e-25 88.6 0.1 6.3e-25 88.1 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Radical_SAM PF04055.21 EFC42809.1 - 0.016 15.6 0.0 0.54 10.6 0.0 2.5 1 1 0 2 2 2 0 Radical SAM superfamily Proteasome PF00227.26 EFC42810.1 - 2.9e-18 66.0 1.7 1.6e-17 63.6 1.7 2.0 1 1 0 1 1 1 1 Proteasome subunit DUF953 PF06110.11 EFC42810.1 - 9.8e-17 60.7 0.0 1.9e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) DUF1827 PF08860.10 EFC42810.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1827) HEAT PF02985.22 EFC42811.1 - 1e-09 37.8 6.9 0.083 13.2 0.0 6.3 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 EFC42811.1 - 3.2e-05 24.2 0.0 0.25 11.7 0.0 3.7 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 EFC42811.1 - 4.4e-05 23.9 0.0 0.55 10.8 0.0 4.1 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 EFC42811.1 - 0.0049 16.9 9.0 1.2 9.2 0.0 3.7 2 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFC42811.1 - 0.023 15.3 7.3 12 6.6 0.5 4.4 3 2 1 4 4 4 0 Vacuolar 14 Fab1-binding region Acyl-CoA_dh_M PF02770.19 EFC42812.1 - 1.1e-15 57.6 0.0 2.2e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain ACOX PF01756.19 EFC42812.1 - 1.7e-13 50.5 1.9 3.8e-13 49.4 1.9 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_1 PF00441.24 EFC42812.1 - 9.9e-09 35.6 0.0 2.1e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 EFC42812.1 - 0.011 16.3 0.6 0.026 15.1 0.1 1.9 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal SIR2 PF02146.17 EFC42813.1 - 6.4e-39 133.7 0.2 1.2e-38 132.8 0.2 1.5 1 0 0 1 1 1 1 Sir2 family zf-ZPR1 PF03367.13 EFC42813.1 - 2.3e-07 30.8 0.0 5.4e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 ZPR1 zinc-finger domain TPP_enzyme_M PF00205.22 EFC42813.1 - 0.01 15.5 0.0 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DNA_pol_B PF00136.21 EFC42814.1 - 9.1e-146 486.2 2.8 1.2e-144 482.5 5.5 1.5 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFC42814.1 - 6.3e-78 262.3 1.3 6.8e-78 262.2 0.2 1.6 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 EFC42814.1 - 6.5e-16 58.6 4.9 1.4e-15 57.5 4.9 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 EFC42814.1 - 0.00094 18.2 0.3 0.0024 16.8 0.1 1.7 1 1 0 1 1 1 1 DNA polymerase type B, organellar and viral TLD PF07534.16 EFC42816.1 - 7.3e-14 52.2 0.3 1.2e-13 51.5 0.3 1.4 1 0 0 1 1 1 1 TLD PBP_like_2 PF12849.7 EFC42817.1 - 4.4e-27 95.5 4.3 5.6e-27 95.1 4.3 1.1 1 0 0 1 1 1 1 PBP superfamily domain DUF792 PF05632.11 EFC42817.1 - 0.046 13.6 0.0 0.088 12.7 0.0 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF792) PBP_like PF12727.7 EFC42817.1 - 0.14 11.3 0.0 0.62 9.2 0.0 1.8 2 0 0 2 2 2 0 PBP superfamily domain YL1_C PF08265.11 EFC42818.1 - 3.9e-08 32.9 1.1 7.2e-08 32.1 1.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Par3_HAL_N_term PF12053.8 EFC42818.1 - 0.66 10.2 6.4 1.4 9.2 0.4 2.9 2 0 0 2 2 2 0 N-terminal of Par3 and HAL proteins MADF_DNA_bdg PF10545.9 EFC42819.1 - 0.0048 17.2 1.4 0.019 15.2 0.3 2.5 2 0 0 2 2 2 1 Alcohol dehydrogenase transcription factor Myb/SANT-like HD_3 PF13023.6 EFC42819.1 - 0.11 12.4 0.9 0.23 11.4 0.9 1.5 1 0 0 1 1 1 0 HD domain DNA_pol_B_N PF18094.1 EFC42819.1 - 0.13 12.8 0.5 0.54 10.8 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase beta N-terminal domain Coat_X PF07552.11 EFC42819.1 - 0.25 11.2 1.9 0.66 9.8 0.8 2.3 2 0 0 2 2 2 0 Spore Coat Protein X and V domain SWIM PF04434.17 EFC42819.1 - 0.55 9.9 4.1 1.2 8.9 4.1 1.4 1 0 0 1 1 1 0 SWIM zinc finger Snf7 PF03357.21 EFC42819.1 - 0.65 9.6 15.7 0.9 9.1 10.8 2.6 2 0 0 2 2 2 0 Snf7 PA26 PF04636.13 EFC42819.1 - 0.78 8.6 6.8 3.3 6.5 0.2 2.4 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) YabA PF06156.13 EFC42819.1 - 0.9 10.2 8.1 1.4 9.6 0.1 3.2 3 0 0 3 3 3 0 Initiation control protein YabA DivIC PF04977.15 EFC42819.1 - 1.8 8.4 5.7 2.1 8.2 0.1 2.7 2 0 0 2 2 2 0 Septum formation initiator ACOX PF01756.19 EFC42820.1 - 2.9e-16 59.5 0.4 2.9e-16 59.5 0.4 1.7 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFC42820.1 - 9.6e-11 41.7 0.0 1.6e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFC42820.1 - 2.4e-06 27.9 0.0 6.7e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 EFC42820.1 - 1.8e-05 25.3 0.1 7.4e-05 23.3 0.0 2.0 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Not3 PF04065.15 EFC42821.1 - 2.8e-61 206.9 39.3 2.8e-61 206.9 39.3 3.7 2 1 1 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component ATP-synt_F6 PF05511.11 EFC42821.1 - 6.8 7.2 12.8 0.32 11.4 0.6 3.8 3 0 0 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 RabGAP-TBC PF00566.18 EFC42822.1 - 1.5e-54 184.9 4.8 4.9e-54 183.2 4.8 2.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRR_6 PF13516.6 EFC42822.1 - 1.9e-07 30.6 3.1 0.0052 16.7 0.2 5.0 5 0 0 5 5 5 2 Leucine Rich repeat YokU PF14122.6 EFC42822.1 - 0.068 13.1 0.1 0.36 10.8 0.1 2.4 1 0 0 1 1 1 0 YokU-like protein, putative antitoxin LRR_1 PF00560.33 EFC42822.1 - 0.084 13.5 1.2 52 5.0 0.1 4.7 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC42822.1 - 1.6 8.5 6.7 0.31 10.8 1.6 2.7 2 0 0 2 2 2 0 Leucine rich repeat TPR_12 PF13424.6 EFC42823.1 - 0.015 15.6 0.1 0.075 13.3 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat ydhR PF08803.11 EFC42824.1 - 0.031 14.2 0.8 0.16 11.9 0.1 2.4 2 1 0 2 2 2 0 Putative mono-oxygenase ydhR DUF3238 PF11579.8 EFC42824.1 - 0.041 13.7 0.0 0.074 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3238) Neur_chan_memb PF02932.16 EFC42824.1 - 1 9.4 6.6 1.8 8.5 6.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region YabA PF06156.13 EFC42824.1 - 5.8 7.6 12.1 3.4 8.4 9.2 2.1 2 0 0 2 2 2 0 Initiation control protein YabA NPC1_N PF16414.5 EFC42825.1 - 7.4e-29 101.0 16.6 3.7e-28 98.7 16.6 1.8 1 1 0 1 1 1 1 Niemann-Pick C1 N terminus SWI-SNF_Ssr4 PF08549.10 EFC42826.1 - 0.23 10.1 7.3 0.29 9.7 7.3 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RWD PF05773.22 EFC42827.1 - 1.8e-20 73.3 2.1 3.1e-20 72.6 2.1 1.4 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 EFC42827.1 - 1.2e-06 28.9 6.9 6.7e-06 26.5 6.9 2.1 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 CLPTM1 PF05602.12 EFC42827.1 - 0.027 13.5 0.1 0.05 12.6 0.1 1.4 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) VPS28 PF03997.12 EFC42827.1 - 0.028 14.1 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 VPS28 protein Acyl-CoA_dh_1 PF00441.24 EFC42828.1 - 6.6e-43 146.5 0.3 8.8e-43 146.1 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFC42828.1 - 8.9e-22 77.1 0.0 1.8e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFC42828.1 - 9.2e-21 74.5 0.0 1.2e-20 74.2 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFC42828.1 - 1.6e-05 25.5 0.0 5e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain CDC27 PF09507.10 EFC42829.1 - 0.0019 17.6 10.7 0.0019 17.6 10.7 3.2 2 1 1 3 3 3 2 DNA polymerase subunit Cdc27 Fer2_2 PF01799.20 EFC42830.1 - 8.5e-27 93.0 0.1 8.3e-26 89.8 0.0 2.4 2 0 0 2 2 2 1 [2Fe-2S] binding domain Fer2 PF00111.27 EFC42830.1 - 3.1e-07 30.3 1.0 6.1e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DFRP_C PF16543.5 EFC42830.1 - 5.2e-06 26.9 8.0 9.3e-06 26.1 6.0 2.4 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 VPS28 PF03997.12 EFC42830.1 - 0.036 13.7 0.1 0.063 12.9 0.1 1.3 1 0 0 1 1 1 0 VPS28 protein Pentapeptide PF00805.22 EFC42831.1 - 4.9e-18 64.4 39.7 2.2e-09 36.8 8.4 5.0 2 1 3 5 5 5 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC42831.1 - 4.4e-17 62.0 32.4 1.8e-12 47.2 12.7 4.1 2 1 2 4 4 4 3 Pentapeptide repeats (9 copies) TLD PF07534.16 EFC42831.1 - 7.9e-16 58.5 1.9 7.9e-16 58.5 1.9 2.7 2 0 0 2 2 2 1 TLD Pentapeptide_3 PF13576.6 EFC42831.1 - 7.7e-13 48.4 26.6 8.8e-08 32.2 9.7 4.9 2 1 3 5 5 5 4 Pentapeptide repeats (9 copies) zf-C3HC4_3 PF13920.6 EFC42831.1 - 0.00063 19.6 6.1 0.00063 19.6 6.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Apolipoprotein PF01442.18 EFC42831.1 - 0.0072 16.2 9.9 0.012 15.6 9.9 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain zf-RING_UBOX PF13445.6 EFC42831.1 - 0.044 13.8 13.5 0.044 13.8 7.5 2.7 2 0 0 2 2 2 0 RING-type zinc-finger OmpH PF03938.14 EFC42831.1 - 0.13 12.6 16.8 0.23 11.8 16.8 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF1640 PF07798.11 EFC42831.1 - 0.17 11.9 7.0 0.32 11.0 7.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Tox-ODYAM1 PF15642.6 EFC42831.1 - 0.24 10.3 5.1 0.38 9.7 5.1 1.3 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus zf-C3HC4_2 PF13923.6 EFC42831.1 - 0.36 10.7 17.1 0.043 13.7 11.8 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1272 PF06906.11 EFC42831.1 - 0.53 10.4 10.0 0.12 12.5 4.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1272) Exonuc_VII_L PF02601.15 EFC42831.1 - 0.77 9.3 4.2 1.1 8.7 4.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 EFC42831.1 - 1.9 7.8 5.5 2.8 7.2 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C3HC4 PF00097.25 EFC42831.1 - 4.5 7.2 18.2 0.2 11.6 10.5 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) YtxH PF12732.7 EFC42831.1 - 4.5 7.9 4.6 10 6.7 4.6 1.6 1 0 0 1 1 1 0 YtxH-like protein Pkinase PF00069.25 EFC42832.1 - 8.9e-78 261.3 0.0 1.1e-77 261.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42832.1 - 1.1e-39 136.2 0.0 3.3e-38 131.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 EFC42832.1 - 0.00048 19.8 0.4 0.00081 19.0 0.4 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 EFC42832.1 - 0.0033 16.8 0.3 0.0071 15.7 0.3 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Anoct_dimer PF16178.5 EFC42832.1 - 0.0071 16.1 1.5 0.0098 15.6 0.7 1.5 2 0 0 2 2 2 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin APH PF01636.23 EFC42832.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family PUF PF00806.19 EFC42833.1 - 6.7e-58 189.2 16.7 6.3e-09 35.0 0.2 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF445 PF04286.12 EFC42833.1 - 0.049 13.4 0.9 0.36 10.6 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF445) SR-25 PF10500.9 EFC42833.1 - 0.43 10.2 12.0 0.85 9.2 12.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3408 PF11888.8 EFC42833.1 - 3.4 7.8 7.6 0.22 11.7 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Guanylate_cyc PF00211.20 EFC42834.1 - 6.2e-34 117.2 0.1 1.2e-33 116.2 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC42834.1 - 9.4e-16 57.8 0.1 1.8e-09 37.6 0.0 2.9 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC42834.1 - 1.7e-11 44.3 2.2 1.1e-07 32.0 0.1 4.0 2 1 1 3 3 3 2 PAS domain PAS_4 PF08448.10 EFC42834.1 - 1.1e-09 38.5 0.0 0.00013 22.2 0.0 2.4 2 0 0 2 2 2 2 PAS fold LRR_4 PF12799.7 EFC42835.1 - 8.1e-13 48.3 46.1 0.001 19.4 3.5 7.2 3 2 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC42835.1 - 3.3e-11 42.8 38.4 0.00022 20.9 3.7 5.4 1 1 6 7 7 7 6 Leucine rich repeat LRR_6 PF13516.6 EFC42835.1 - 6.3e-09 35.2 40.0 0.0072 16.3 0.1 8.9 9 0 0 9 9 9 5 Leucine Rich repeat F-box-like PF12937.7 EFC42835.1 - 0.0028 17.5 0.9 0.0063 16.4 0.9 1.6 1 0 0 1 1 1 1 F-box-like LRR_9 PF14580.6 EFC42835.1 - 0.021 14.4 13.3 0.026 14.0 2.2 2.6 1 1 1 2 2 2 0 Leucine-rich repeat F-box PF00646.33 EFC42835.1 - 0.59 10.1 5.4 1.9 8.5 3.0 3.1 2 1 0 2 2 2 0 F-box domain TFIIB PF00382.19 EFC42837.1 - 1e-13 51.1 0.0 2.1e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 EFC42837.1 - 8.4e-09 34.8 4.4 8.4e-09 34.8 4.4 2.2 2 0 0 2 2 2 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 EFC42837.1 - 0.024 14.5 1.0 0.062 13.2 1.0 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain HARE-HTH PF05066.13 EFC42837.1 - 0.029 14.8 0.0 16 6.0 0.0 3.2 3 0 0 3 3 3 0 HB1, ASXL, restriction endonuclease HTH domain NLRC4_HD2 PF17776.1 EFC42837.1 - 0.053 14.1 1.1 0.61 10.6 0.5 2.4 1 1 0 2 2 2 0 NLRC4 helical domain HD2 DUF5314 PF17241.2 EFC42837.1 - 0.054 13.2 1.1 0.42 10.3 0.2 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5314) HTH_3 PF01381.22 EFC42837.1 - 0.1 12.7 0.0 21 5.3 0.0 2.8 3 0 0 3 3 3 0 Helix-turn-helix HTH_17 PF12728.7 EFC42837.1 - 0.12 12.6 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain FYVE_2 PF02318.16 EFC42837.1 - 0.42 10.8 5.9 5.9 7.1 0.3 2.5 2 0 0 2 2 2 0 FYVE-type zinc finger DnaJ PF00226.31 EFC42838.1 - 1.3e-22 79.7 5.5 1.7e-22 79.3 4.0 1.9 2 0 0 2 2 2 1 DnaJ domain SLATT_5 PF18160.1 EFC42838.1 - 0.14 11.5 3.9 0.16 11.3 1.4 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF4460 PF14687.6 EFC42838.1 - 0.22 11.6 3.1 0.31 11.1 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) RRM_1 PF00076.22 EFC42839.1 - 1.6e-27 95.1 0.0 2.5e-12 46.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC42839.1 - 4.2e-05 23.6 0.1 0.1 12.7 0.0 3.4 2 2 0 2 2 2 2 RNA recognition motif RL PF17797.1 EFC42839.1 - 0.021 14.7 0.0 0.086 12.8 0.0 2.1 2 0 0 2 2 2 0 RL domain NID PF07292.13 EFC42839.1 - 0.14 12.8 0.1 1.2 9.8 0.0 2.6 4 0 0 4 4 4 0 Nmi/IFP 35 domain (NID) Ank_2 PF12796.7 EFC42840.1 - 8.3e-13 48.7 0.0 2.3e-12 47.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC42840.1 - 1.8e-11 44.3 0.0 5.3e-11 42.8 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42840.1 - 6.9e-11 41.4 0.0 0.00012 22.2 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFC42840.1 - 6.6e-07 29.5 0.0 0.047 14.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC42840.1 - 4.5e-05 23.7 0.0 0.36 11.3 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat TPR_1 PF00515.28 EFC42840.1 - 0.0021 17.8 0.3 0.11 12.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF1759 PF03564.15 EFC42840.1 - 0.039 13.9 0.8 0.098 12.6 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) DUF5049 PF16468.5 EFC42840.1 - 0.055 13.4 0.9 43 4.1 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) TPR_8 PF13181.6 EFC42840.1 - 0.11 12.8 2.5 0.42 10.9 0.0 3.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC42840.1 - 0.17 12.4 0.1 5.3 7.6 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 EFC42840.1 - 1.5 8.9 4.0 9.6 6.4 0.0 3.8 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain Tn7_Tnp_TnsA_C PF08721.11 EFC42840.1 - 1.8 9.3 6.0 1.4 9.6 0.2 3.4 4 0 0 4 4 4 0 TnsA endonuclease C terminal DUF3447 PF11929.8 EFC42840.1 - 7 6.7 12.8 0.31 11.0 0.2 4.1 2 2 2 4 4 3 0 Domain of unknown function (DUF3447) NHL PF01436.21 EFC42841.1 - 1.8e-12 46.6 0.1 0.0071 16.3 0.0 4.8 4 0 0 4 4 4 3 NHL repeat SGL PF08450.12 EFC42841.1 - 0.0053 16.4 0.0 0.06 12.9 0.0 2.5 2 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region NOA36 PF06524.12 EFC42841.1 - 2.7 7.2 8.6 4.3 6.6 8.6 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 EFC42841.1 - 4.3 6.4 9.5 5.9 5.9 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-CCCH_4 PF18044.1 EFC42842.1 - 1.7e-06 27.7 3.7 3.2e-06 26.8 3.7 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger CCSAP PF15748.5 EFC42842.1 - 0.012 15.8 11.4 0.028 14.6 11.4 1.6 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated zf_CCCH_4 PF18345.1 EFC42842.1 - 0.014 15.5 9.3 0.032 14.3 9.3 1.7 1 0 0 1 1 1 0 Zinc finger domain CDC45 PF02724.14 EFC42842.1 - 0.031 12.6 29.0 0.064 11.5 29.0 1.6 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 EFC42842.1 - 0.28 9.9 9.9 0.56 8.9 9.9 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.12 EFC42842.1 - 1.3 7.2 38.5 2.2 6.4 38.5 1.3 1 0 0 1 1 1 0 Nop14-like family DUF3391 PF11871.8 EFC42842.1 - 1.6 9.3 9.9 3.7 8.1 9.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) 2-Hacid_dh_C PF02826.19 EFC42844.1 - 1.2e-50 171.3 0.0 1.7e-49 167.6 0.0 2.4 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFC42844.1 - 6e-37 126.3 0.1 9.8e-37 125.6 0.0 1.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFC42844.1 - 5.4e-06 26.7 2.4 9.6e-06 25.8 0.0 2.6 4 1 0 4 4 4 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 EFC42844.1 - 0.045 14.3 0.0 0.22 12.0 0.0 2.1 2 0 0 2 2 2 0 XdhC Rossmann domain Amdase PF17645.1 EFC42844.1 - 0.1 12.2 0.1 0.24 11.0 0.1 1.5 2 0 0 2 2 2 0 Arylmalonate decarboxylase IlvN PF07991.12 EFC42844.1 - 0.11 12.0 0.2 0.32 10.6 0.1 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Rossmann-like PF10727.9 EFC42844.1 - 0.17 11.8 1.0 1.4 8.8 1.0 2.2 1 1 0 1 1 1 0 Rossmann-like domain DASH_Dad4 PF08650.10 EFC42845.1 - 0.79 9.7 13.1 0.68 9.9 2.0 3.8 3 0 0 3 3 3 0 DASH complex subunit Dad4 C2 PF00168.30 EFC42846.1 - 2e-22 79.4 0.1 2.6e-22 79.1 0.1 1.1 1 0 0 1 1 1 1 C2 domain nsp8 PF08717.10 EFC42847.1 - 0.016 15.1 2.2 0.042 13.7 2.2 1.7 1 0 0 1 1 1 0 nsp8 replicase RGS PF00615.19 EFC42847.1 - 0.14 12.4 9.3 0.11 12.8 5.3 2.6 2 0 0 2 2 2 0 Regulator of G protein signaling domain DUF5411 PF17424.2 EFC42847.1 - 0.16 11.9 1.0 0.34 10.9 1.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5411) PIN_12 PF16289.5 EFC42847.1 - 1.4 9.3 12.8 0.27 11.7 8.8 1.9 2 0 0 2 2 2 0 PIN domain PhyH PF05721.13 EFC42848.1 - 2.2e-09 37.9 0.0 4.2e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HEAT_2 PF13646.6 EFC42848.1 - 0.00025 21.4 0.0 0.15 12.5 0.0 2.8 2 1 1 3 3 3 3 HEAT repeats ComR_TPR PF18710.1 EFC42848.1 - 0.065 12.8 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 ComR tetratricopeptide F-box PF00646.33 EFC42849.1 - 0.0011 18.8 0.0 0.0028 17.5 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC42849.1 - 0.0017 18.2 0.3 0.0058 16.5 0.0 2.0 2 0 0 2 2 2 1 F-box-like DUF1963 PF09234.10 EFC42849.1 - 0.053 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) SPRY PF00622.28 EFC42850.1 - 4.3e-10 39.8 0.2 2.6e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 SPRY domain Endonuc_Holl PF10107.9 EFC42850.1 - 0.00048 20.0 0.1 0.0011 18.9 0.1 1.5 1 0 0 1 1 1 1 Endonuclease related to archaeal Holliday junction resolvase Com_YlbF PF06133.11 EFC42851.1 - 9.3 6.9 13.5 0.2 12.3 1.6 3.6 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA DUF572 PF04502.13 EFC42852.1 - 1.1e-44 153.4 21.0 3.3e-22 79.6 0.1 2.2 2 0 0 2 2 2 2 Family of unknown function (DUF572) ABC2_membrane_3 PF12698.7 EFC42852.1 - 2.6 7.0 5.8 6.3 5.8 1.0 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein NUDIX PF00293.28 EFC42853.1 - 0.0022 18.0 0.0 0.0059 16.6 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain SUR7 PF06687.12 EFC42854.1 - 0.041 13.5 1.3 0.06 13.0 0.8 1.4 1 1 0 1 1 1 0 SUR7/PalI family PH PF00169.29 EFC42855.1 - 1.4e-36 125.2 7.5 1.4e-18 67.3 0.1 3.3 3 0 0 3 3 3 2 PH domain ArfGap PF01412.18 EFC42855.1 - 3.7e-36 123.8 2.5 3.7e-36 123.8 2.5 2.8 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf PH_11 PF15413.6 EFC42855.1 - 2.7e-12 47.0 16.7 8e-06 26.2 4.0 5.5 3 2 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 EFC42855.1 - 1.1e-10 41.6 7.0 1.7e-05 25.0 0.0 3.0 3 0 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 EFC42855.1 - 4.5e-06 27.0 4.5 0.35 11.2 0.0 4.4 2 2 1 3 3 3 2 Pleckstrin homology domain PH_2 PF08458.10 EFC42855.1 - 0.019 15.3 0.2 0.91 9.9 0.0 2.8 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_13 PF16652.5 EFC42855.1 - 0.03 14.1 1.7 0.29 10.9 0.1 3.3 3 0 0 3 3 3 0 Pleckstrin homology domain PH_6 PF15406.6 EFC42855.1 - 0.13 12.5 1.2 0.4 11.0 0.0 2.5 3 0 0 3 3 3 0 Pleckstrin homology domain FAD_binding_1 PF00667.20 EFC42856.1 - 1.9e-24 86.5 0.3 3.9e-24 85.5 0.3 1.6 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 EFC42856.1 - 4.7e-21 75.5 0.0 1.3e-20 74.1 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Flavodoxin_1 PF00258.25 EFC42856.1 - 5.3e-18 65.6 0.0 1.5e-17 64.1 0.0 1.9 1 0 0 1 1 1 1 Flavodoxin NAD_binding_6 PF08030.12 EFC42856.1 - 0.28 11.3 0.0 0.28 11.3 0.0 2.7 3 0 0 3 3 3 0 Ferric reductase NAD binding domain GRIM-19 PF06212.12 EFC42857.1 - 0.13 12.2 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 GRIM-19 protein Radical_SAM PF04055.21 EFC42858.1 - 2e-06 28.3 0.0 4.6e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily RUN PF02759.19 EFC42859.1 - 1.7e-10 41.0 0.9 1.7e-07 31.3 0.0 3.0 2 0 0 2 2 2 2 RUN domain Ribosomal_L30 PF00327.20 EFC42860.1 - 6.6e-10 38.7 1.1 1.2e-09 37.9 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e DUF3699 PF12480.8 EFC42860.1 - 0.058 13.6 1.4 0.57 10.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3699) LUC7 PF03194.15 EFC42861.1 - 3.7e-60 203.7 7.7 5.9e-60 203.0 7.7 1.2 1 0 0 1 1 1 1 LUC7 N_terminus HlyD_2 PF12700.7 EFC42861.1 - 0.062 12.0 11.4 0.096 11.4 11.4 1.2 1 0 0 1 1 1 0 HlyD family secretion protein DUF4175 PF13779.6 EFC42861.1 - 0.072 11.0 4.4 0.093 10.6 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) GyrB_insert PF18053.1 EFC42861.1 - 0.24 11.3 3.2 0.42 10.5 3.2 1.3 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain Prominin PF05478.11 EFC42861.1 - 0.28 9.1 3.1 0.39 8.6 3.1 1.1 1 0 0 1 1 1 0 Prominin Phasin PF05597.11 EFC42861.1 - 0.69 9.9 8.4 0.75 9.8 4.2 2.6 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4363 PF14276.6 EFC42861.1 - 2.8 8.1 10.6 7.2 6.8 10.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) DUF1090 PF06476.12 EFC42861.1 - 5.5 7.2 23.9 0.91 9.7 11.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1090) V_ATPase_I PF01496.19 EFC42861.1 - 8 4.2 7.7 10 3.9 7.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Apolipoprotein PF01442.18 EFC42862.1 - 0.00015 21.7 10.6 0.27 11.1 4.7 3.2 2 1 0 2 2 2 2 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EFC42862.1 - 0.048 13.7 20.5 0.25 11.4 1.1 3.5 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus CLZ PF16526.5 EFC42862.1 - 0.07 13.5 9.3 2.8 8.4 3.0 4.1 2 2 2 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels GCP_C_terminal PF04130.13 EFC42862.1 - 0.27 10.7 6.0 0.074 12.5 2.0 1.9 2 0 0 2 2 2 0 Gamma tubulin complex component C-terminal COG5 PF10392.9 EFC42862.1 - 0.33 11.1 16.7 0.077 13.2 6.1 3.8 2 2 2 4 4 4 0 Golgi transport complex subunit 5 Ribosomal_S20p PF01649.18 EFC42862.1 - 0.38 11.4 9.5 0.79 10.4 0.8 4.1 2 1 0 2 2 2 0 Ribosomal protein S20 DUF1640 PF07798.11 EFC42862.1 - 0.67 10.0 26.8 0.071 13.2 4.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1640) YtxH PF12732.7 EFC42862.1 - 0.99 10.0 12.8 7.2 7.2 1.4 4.2 2 2 0 2 2 2 0 YtxH-like protein Fib_alpha PF08702.10 EFC42862.1 - 1 9.5 24.8 0.1 12.7 7.4 3.7 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family BST2 PF16716.5 EFC42862.1 - 1.5 9.4 11.2 7.9 7.1 1.8 3.4 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 DASH_Dam1 PF08653.10 EFC42862.1 - 1.6 8.6 7.7 11 6.0 0.1 4.1 5 0 0 5 5 4 0 DASH complex subunit Dam1 Exonuc_VII_S PF02609.16 EFC42862.1 - 1.6 8.9 6.7 0.6 10.2 0.1 3.7 4 0 0 4 4 4 0 Exonuclease VII small subunit ApoC-I PF04691.12 EFC42862.1 - 3.4 7.6 7.1 14 5.7 0.1 4.5 4 2 0 4 4 4 0 Apolipoprotein C-I (ApoC-1) Rx_N PF18052.1 EFC42862.1 - 3.6 7.9 8.9 3.2 8.1 0.1 3.8 3 1 1 4 4 4 0 Rx N-terminal domain Vps51 PF08700.11 EFC42862.1 - 4.1 7.6 11.1 0.87 9.7 3.5 3.3 3 0 0 3 3 3 0 Vps51/Vps67 V-SNARE_C PF12352.8 EFC42862.1 - 4.1 7.8 7.4 31 4.9 0.8 3.6 4 0 0 4 4 3 0 Snare region anchored in the vesicle membrane C-terminus SlyX PF04102.12 EFC42862.1 - 5.8 7.6 8.2 50 4.6 0.3 3.8 3 0 0 3 3 3 0 SlyX KxDL PF10241.9 EFC42862.1 - 6 7.2 21.9 7.8 6.8 2.2 4.0 3 1 1 4 4 4 0 Uncharacterized conserved protein DUF1664 PF07889.12 EFC42862.1 - 9 6.4 24.9 16 5.6 5.3 4.8 2 2 3 5 5 5 0 Protein of unknown function (DUF1664) HGTP_anticodon PF03129.20 EFC42863.1 - 4.5e-22 78.0 0.2 1.2e-21 76.7 0.1 1.8 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFC42863.1 - 4.7e-08 33.2 0.0 3.1e-07 30.6 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Kelch_5 PF13854.6 EFC42864.1 - 3.2e-37 125.9 7.6 1.1e-08 34.8 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFC42864.1 - 1.5e-30 104.4 11.1 1.5e-07 31.5 0.0 6.3 4 1 2 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFC42864.1 - 9.9e-29 99.1 11.1 6.5e-08 32.5 0.1 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC42864.1 - 2.8e-28 97.6 8.2 1.1e-08 35.2 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC42864.1 - 1.1e-25 88.9 11.9 1.7e-07 30.7 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 EFC42864.1 - 2.4e-16 59.0 13.3 0.00019 21.3 0.0 6.6 6 1 0 6 6 6 5 Kelch motif Methyltransf_23 PF13489.6 EFC42865.1 - 6.8e-05 22.8 0.0 8.7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC42865.1 - 0.0032 18.2 0.0 0.0074 17.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PI_PP_I PF18363.1 EFC42865.1 - 0.0085 16.3 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 Phosphoinositide phosphatase insertion domain Methyltransf_11 PF08241.12 EFC42865.1 - 0.048 14.3 0.0 0.95 10.1 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain DUF1657 PF07870.11 EFC42865.1 - 1.3 8.9 6.1 0.9 9.5 0.6 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1657) BTB PF00651.31 EFC42866.1 - 1.4e-12 47.9 6.3 5.3e-11 42.7 0.8 2.9 3 0 0 3 3 3 2 BTB/POZ domain Ank_2 PF12796.7 EFC42866.1 - 0.002 18.7 0.0 0.006 17.1 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF3342 PF11822.8 EFC42866.1 - 0.0036 17.5 0.2 0.014 15.5 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Ank_5 PF13857.6 EFC42866.1 - 0.087 13.2 0.0 0.37 11.2 0.0 2.1 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42866.1 - 0.12 13.0 0.1 0.55 11.0 0.1 2.2 1 0 0 1 1 1 0 Ankyrin repeat RCC1 PF00415.18 EFC42868.1 - 1.9e-34 118.1 1.2 0.00014 22.4 0.0 7.7 6 2 1 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC42868.1 - 5.3e-21 73.9 10.9 4.2e-05 23.2 0.0 7.0 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat Kelch_1 PF01344.25 EFC42868.1 - 0.48 10.0 5.4 8.9 6.0 0.5 3.9 4 0 0 4 4 4 0 Kelch motif F-box PF00646.33 EFC42869.1 - 0.027 14.3 2.0 0.095 12.6 0.4 2.7 2 0 0 2 2 2 0 F-box domain EGF_2 PF07974.13 EFC42870.1 - 1.9e-16 60.1 60.9 0.00011 22.4 7.1 5.0 3 1 1 4 4 4 4 EGF-like domain NHL PF01436.21 EFC42870.1 - 1.2e-15 56.7 4.4 0.00043 20.2 0.0 7.9 8 0 0 8 8 8 3 NHL repeat hEGF PF12661.7 EFC42870.1 - 6.2e-06 26.7 53.3 0.033 14.8 6.7 6.0 4 1 1 5 5 5 4 Human growth factor-like EGF EGF PF00008.27 EFC42870.1 - 0.00085 19.6 57.7 0.077 13.3 8.0 5.5 5 1 0 5 5 5 4 EGF-like domain Stevor PF17410.2 EFC42870.1 - 0.018 14.6 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Ly49 PF08391.10 EFC42870.1 - 0.11 12.9 0.1 0.26 11.6 0.1 1.6 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF4595 PF15283.6 EFC42870.1 - 0.11 12.5 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4595) with porin-like fold RIFIN PF02009.16 EFC42870.1 - 0.12 12.3 0.5 0.19 11.6 0.5 1.2 1 0 0 1 1 1 0 Rifin phage_tail_N PF08400.10 EFC42871.1 - 0.015 15.2 0.7 0.051 13.6 0.1 1.8 2 0 0 2 2 2 0 Prophage tail fibre N-terminal ABC_tran PF00005.27 EFC42872.1 - 7.7e-23 81.5 0.0 1.4e-22 80.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EFC42872.1 - 0.019 14.9 0.1 0.045 13.7 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EFC42872.1 - 0.076 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC42872.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad51 PF08423.11 EFC42872.1 - 0.12 11.6 0.2 0.21 10.8 0.2 1.3 1 0 0 1 1 1 0 Rad51 AAA_14 PF13173.6 EFC42872.1 - 0.17 11.9 1.0 0.99 9.4 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC42872.1 - 0.17 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Arm PF00514.23 EFC42876.1 - 1.6e-22 78.7 4.9 9.6e-06 25.5 0.2 5.5 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat KAP PF05804.12 EFC42876.1 - 1.2e-07 30.3 7.5 5.6e-07 28.1 7.7 1.6 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) HEAT_EZ PF13513.6 EFC42876.1 - 7.7e-06 26.3 0.1 0.084 13.4 0.0 3.9 4 0 0 4 4 4 1 HEAT-like repeat V-ATPase_H_N PF03224.14 EFC42876.1 - 6e-05 22.5 7.4 0.14 11.4 0.0 2.3 1 1 1 2 2 2 2 V-ATPase subunit H HEAT PF02985.22 EFC42876.1 - 7.2e-05 22.7 0.4 2.9 8.4 0.1 4.3 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 EFC42876.1 - 7.8e-05 23.0 0.1 0.0054 17.1 0.0 3.3 1 1 3 4 4 4 1 HEAT repeats V-ATPase_H_C PF11698.8 EFC42876.1 - 0.0064 16.6 9.9 0.013 15.6 0.1 3.9 2 2 2 4 4 4 2 V-ATPase subunit H SporV_AA PF12164.8 EFC42876.1 - 0.014 15.8 2.1 0.039 14.3 0.2 2.6 3 0 0 3 3 3 0 Stage V sporulation protein AA DUF4490 PF14892.6 EFC42877.1 - 2.6e-14 53.1 1.9 3e-14 52.9 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4490) TPR_11 PF13414.6 EFC42878.1 - 9.5e-07 28.4 3.0 6.1e-05 22.6 0.2 3.6 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.17 EFC42878.1 - 5.2e-05 23.0 7.4 6.8 7.1 0.0 5.9 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC42878.1 - 0.00038 20.9 2.0 9.6 7.1 0.1 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC42878.1 - 0.029 14.7 0.1 0.029 14.7 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC42878.1 - 0.19 12.0 11.2 16 6.0 0.1 5.7 6 1 0 6 6 6 0 Tetratricopeptide repeat AA_permease PF00324.21 EFC42879.1 - 6.2e-39 133.9 54.4 8.8e-39 133.4 54.4 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 EFC42879.1 - 1.6e-29 103.2 6.1 1.7e-12 47.1 0.2 3.4 3 1 1 4 4 4 3 Solute carrier family 12 AA_permease_2 PF13520.6 EFC42879.1 - 8.9e-21 74.2 58.9 1.4e-20 73.6 58.9 1.3 1 0 0 1 1 1 1 Amino acid permease SKIP_SNW PF02731.15 EFC42881.1 - 7.3e-54 181.8 1.0 2e-53 180.4 0.3 2.1 2 0 0 2 2 2 1 SKIP/SNW domain DLIC PF05783.11 EFC42882.1 - 2.4e-07 30.0 0.1 2.4e-07 30.0 0.1 2.2 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) Roc PF08477.13 EFC42882.1 - 0.00015 22.0 0.0 0.00044 20.5 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC42882.1 - 0.0012 18.3 0.1 0.0021 17.5 0.1 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EFC42882.1 - 0.0077 16.6 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Ras PF00071.22 EFC42882.1 - 0.011 15.3 0.1 0.028 14.0 0.1 1.7 1 1 0 1 1 1 0 Ras family FtsK_SpoIIIE PF01580.18 EFC42882.1 - 0.18 11.1 0.6 0.43 9.9 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family YxiJ PF14176.6 EFC42882.1 - 0.21 12.1 4.2 0.42 11.1 0.2 2.6 2 1 0 2 2 2 0 YxiJ-like protein Ank_2 PF12796.7 EFC42883.1 - 2e-33 114.8 5.4 1.9e-13 50.8 0.2 5.4 1 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC42883.1 - 6.2e-32 109.6 3.3 2e-09 37.8 0.1 6.5 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC42883.1 - 1.3e-23 82.7 4.4 1.4e-05 25.3 0.0 7.1 4 1 3 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42883.1 - 3.2e-22 76.2 4.9 0.04 14.5 0.0 8.6 8 0 0 8 8 8 6 Ankyrin repeat Ank PF00023.30 EFC42883.1 - 3.8e-21 74.5 3.9 0.0075 16.7 0.0 7.9 7 0 0 7 7 7 6 Ankyrin repeat PBP PF01161.20 EFC42883.1 - 2.9e-10 40.6 0.0 8.9e-10 39.0 0.0 1.8 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein UCH PF00443.29 EFC42886.1 - 6.5e-29 101.2 0.7 1.3e-28 100.2 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC42886.1 - 1.6e-16 60.8 0.9 1.6e-16 60.8 0.9 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4407 PF14362.6 EFC42887.1 - 0.00042 19.8 17.2 0.00042 19.8 17.2 4.7 1 1 4 5 5 5 1 Domain of unknown function (DUF4407) DUF1192 PF06698.11 EFC42887.1 - 0.0053 16.8 0.3 0.0053 16.8 0.3 4.0 4 0 0 4 4 4 1 Protein of unknown function (DUF1192) SlyX PF04102.12 EFC42887.1 - 0.022 15.3 1.3 0.022 15.3 1.3 10.6 4 4 4 9 9 9 0 SlyX KASH_CCD PF14662.6 EFC42887.1 - 0.38 10.6 113.3 0.51 10.1 27.9 6.7 1 1 5 6 6 6 0 Coiled-coil region of CCDC155 or KASH GP40 PF11025.8 EFC42887.1 - 2.8 7.7 5.8 2.3 8.0 3.8 1.9 2 0 0 2 2 2 0 Glycoprotein GP40 of Cryptosporidium Voldacs PF03517.13 EFC42888.1 - 0.019 15.1 9.3 0.023 14.8 9.3 1.2 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling Neur_chan_memb PF02932.16 EFC42888.1 - 1.8 8.6 5.3 2 8.4 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Lin-8 PF03353.15 EFC42888.1 - 1.8 8.1 11.9 1.8 8.1 11.9 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 EFC42888.1 - 3.3 6.4 8.8 3.9 6.1 8.8 1.0 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 EFC42888.1 - 4.6 7.1 20.5 5.5 6.9 20.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 EFC42890.1 - 9.4e-65 218.6 0.1 1.2e-64 218.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42890.1 - 3.2e-34 118.4 0.0 4.6e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH_3 PF14593.6 EFC42890.1 - 1e-30 105.9 1.8 1e-30 105.9 1.8 2.0 3 0 0 3 3 3 1 PH domain Kinase-like PF14531.6 EFC42890.1 - 1.1e-07 31.4 0.0 2.9e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFC42890.1 - 7.2e-05 21.9 0.2 0.00013 21.0 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 EFC42890.1 - 0.00043 20.0 0.2 0.18 11.4 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFC42890.1 - 0.012 14.9 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC42890.1 - 0.017 15.1 0.0 0.049 13.5 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFC42890.1 - 0.022 14.3 0.9 0.063 12.9 0.0 2.0 2 0 0 2 2 2 0 RIO1 family Sushi_2 PF09014.10 EFC42890.1 - 0.034 14.0 0.3 0.13 12.1 0.0 2.0 2 0 0 2 2 2 0 Beta-2-glycoprotein-1 fifth domain Pkinase_fungal PF17667.1 EFC42890.1 - 0.12 11.1 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase AAA PF00004.29 EFC42891.1 - 6e-52 175.6 0.0 8.5e-35 120.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC42891.1 - 2.1e-09 37.0 0.1 2.1e-08 33.8 0.0 2.4 2 0 0 2 2 2 1 AAA+ lid domain AAA_14 PF13173.6 EFC42891.1 - 6e-08 32.8 0.0 0.0018 18.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 EFC42891.1 - 1.9e-07 31.0 0.1 0.011 15.5 0.0 3.4 4 1 0 4 4 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFC42891.1 - 2.9e-07 31.0 1.1 0.058 13.8 0.0 3.8 2 2 1 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 EFC42891.1 - 3e-06 27.5 0.3 0.29 11.4 0.0 3.4 2 1 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 EFC42891.1 - 5e-06 26.9 0.1 0.16 12.4 0.0 3.2 3 0 0 3 3 3 2 RNA helicase TIP49 PF06068.13 EFC42891.1 - 1.2e-05 24.7 0.1 0.012 14.9 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain DUF815 PF05673.13 EFC42891.1 - 0.00023 20.4 0.0 0.68 9.1 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF815) AAA_5 PF07728.14 EFC42891.1 - 0.00047 20.2 0.0 0.015 15.3 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 EFC42891.1 - 0.0013 18.7 0.0 0.0041 17.1 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 EFC42891.1 - 0.0014 18.4 0.0 0.15 11.8 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein Rad17 PF03215.15 EFC42891.1 - 0.0016 18.4 0.2 0.51 10.2 0.0 2.9 3 0 0 3 3 3 1 Rad17 P-loop domain Zot PF05707.12 EFC42891.1 - 0.0016 18.1 2.1 2.5 7.7 0.0 4.0 3 2 1 4 4 3 1 Zonular occludens toxin (Zot) AAA_7 PF12775.7 EFC42891.1 - 0.0047 16.5 0.0 0.82 9.2 0.0 3.0 3 0 0 3 3 3 1 P-loop containing dynein motor region TsaE PF02367.17 EFC42891.1 - 0.0054 16.7 0.0 4.2 7.4 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 EFC42891.1 - 0.0054 16.4 0.4 1.4 8.7 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EFC42891.1 - 0.0073 16.2 0.3 17 5.3 0.0 3.6 3 1 1 4 4 4 0 NACHT domain Sigma54_activat PF00158.26 EFC42891.1 - 0.01 15.5 0.0 0.13 12.0 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFC42891.1 - 0.013 14.9 0.0 0.053 12.9 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 EFC42891.1 - 0.019 15.1 0.0 0.19 11.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 EFC42891.1 - 0.02 14.2 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_33 PF13671.6 EFC42891.1 - 0.029 14.5 0.0 0.33 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EFC42891.1 - 0.031 13.5 0.2 15 4.7 0.0 3.0 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 EFC42891.1 - 0.034 14.0 0.0 0.38 10.6 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFC42891.1 - 0.038 14.5 0.0 8.5 6.9 0.0 2.8 3 0 0 3 3 2 0 ABC transporter AAA_18 PF13238.6 EFC42891.1 - 0.046 14.3 0.0 7.8 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 EFC42891.1 - 0.05 13.0 0.1 3.6 6.9 0.0 3.0 2 2 1 3 3 3 0 Bacterial TniB protein AAA_25 PF13481.6 EFC42891.1 - 0.064 12.8 0.1 18 4.8 0.1 3.6 3 1 1 4 4 4 0 AAA domain AAA_17 PF13207.6 EFC42891.1 - 0.11 12.9 0.0 1 9.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EFC42891.1 - 0.11 11.6 0.0 13 4.9 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain Dus PF01207.17 EFC42892.1 - 1.2e-48 165.8 0.0 1.4e-47 162.3 0.0 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) Imm6 PF14434.6 EFC42892.1 - 0.079 12.9 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Immunity protein Imm6 Rio2_N PF09202.11 EFC42893.1 - 2e-33 114.4 0.1 3.7e-33 113.6 0.1 1.5 1 0 0 1 1 1 1 Rio2, N-terminal RIO1 PF01163.22 EFC42893.1 - 2.2e-15 56.7 0.0 8e-15 54.9 0.0 1.8 2 0 0 2 2 2 1 RIO1 family ResIII PF04851.15 EFC42894.1 - 7.8e-19 68.3 6.1 3.9e-18 66.0 0.0 3.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC42894.1 - 1.4e-18 67.2 3.8 1.9e-18 66.8 0.2 3.2 5 0 0 5 5 5 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC42894.1 - 1.3e-14 54.4 0.0 3.4e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ER PF01133.17 EFC42894.1 - 0.2 11.7 2.2 0.22 11.5 0.3 2.1 2 0 0 2 2 2 0 Enhancer of rudimentary C2 PF00168.30 EFC42897.1 - 4.4e-11 43.0 0.9 3.3e-10 40.2 0.1 2.6 2 0 0 2 2 2 1 C2 domain TerD PF02342.18 EFC42897.1 - 0.0003 20.3 0.0 0.00085 18.9 0.0 1.7 1 0 0 1 1 1 1 TerD domain Alk_phosphatase PF00245.20 EFC42898.1 - 2.6e-112 375.8 1.6 3.1e-112 375.6 1.6 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 EFC42898.1 - 6.2e-06 25.7 0.3 7.9e-05 22.1 0.2 2.2 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF3976 PF13121.6 EFC42898.1 - 0.053 13.6 1.1 1.3 9.2 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3976) FA_desaturase PF00487.24 EFC42900.1 - 1.1e-22 81.2 8.5 1.1e-22 81.2 8.5 1.8 2 0 0 2 2 2 1 Fatty acid desaturase LRR_6 PF13516.6 EFC42901.1 - 6.7e-05 22.6 1.6 1.2 9.4 0.1 4.5 4 0 0 4 4 4 2 Leucine Rich repeat FTH PF01827.27 EFC42901.1 - 0.018 14.8 6.4 0.86 9.4 0.4 2.2 1 1 1 2 2 2 0 FTH domain LRR_4 PF12799.7 EFC42901.1 - 0.15 12.5 19.3 0.15 12.5 3.9 5.0 1 1 5 6 6 6 0 Leucine Rich repeats (2 copies) PA26 PF04636.13 EFC42903.1 - 4.7e-126 421.3 7.1 9e-126 420.3 7.1 1.4 1 1 0 1 1 1 1 PA26 p53-induced protein (sestrin) BING4CT PF08149.11 EFC42903.1 - 0.14 11.9 0.4 5.6 6.8 0.0 2.6 2 1 0 2 2 2 0 BING4CT (NUC141) domain FAD-oxidase_C PF02913.19 EFC42905.1 - 5.8e-61 206.3 0.0 7.5e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 EFC42905.1 - 2e-31 108.6 0.0 4.2e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain RRM_1 PF00076.22 EFC42906.1 - 5.8e-31 106.1 0.2 2e-10 40.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFC42906.1 - 7e-06 25.9 1.2 0.0063 16.5 0.1 3.0 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 EFC42906.1 - 0.0085 15.9 0.0 0.85 9.5 0.0 3.0 3 1 0 3 3 3 1 Occluded RNA-recognition motif RL PF17797.1 EFC42906.1 - 0.03 14.2 2.5 1.4 9.0 0.1 3.2 3 0 0 3 3 3 0 RL domain PAC2 PF09754.9 EFC42906.1 - 0.072 13.1 0.0 0.26 11.2 0.0 1.8 2 0 0 2 2 2 0 PAC2 family LMBR1 PF04791.16 EFC42907.1 - 0.57 9.0 5.6 0.7 8.7 5.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Mucin PF01456.17 EFC42907.1 - 2.3 8.2 13.6 2.9 7.9 13.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein XAP5 PF04921.14 EFC42907.1 - 2.9 7.6 11.8 3.6 7.3 11.8 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Presenilin PF01080.17 EFC42907.1 - 7.3 5.2 8.9 8.9 5.0 8.9 1.0 1 0 0 1 1 1 0 Presenilin Vezatin PF12632.7 EFC42908.1 - 3.8e-06 26.5 0.5 3.8e-06 26.5 0.5 2.0 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes GCV_H PF01597.19 EFC42909.1 - 4.2e-34 117.1 4.3 5.3e-34 116.7 4.3 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl PF00364.22 EFC42909.1 - 5.8e-07 29.3 2.1 1e-06 28.4 2.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme RnfC_N PF13375.6 EFC42909.1 - 2.4e-05 24.2 1.3 3.3e-05 23.8 1.3 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain ACT_4 PF13291.6 EFC42909.1 - 0.0059 17.2 1.8 0.06 13.9 0.3 2.4 3 0 0 3 3 3 1 ACT domain Colicin_E5 PF12106.8 EFC42909.1 - 0.053 13.8 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Colicin E5 ribonuclease domain Peptidase_M23 PF01551.22 EFC42909.1 - 0.36 11.1 2.5 2.9 8.1 0.7 2.2 1 1 1 2 2 2 0 Peptidase family M23 SH3_1 PF00018.28 EFC42910.1 - 3.8e-31 106.4 0.8 7.5e-15 54.3 0.1 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 EFC42910.1 - 9.7e-29 99.0 0.2 1.7e-14 53.4 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EFC42910.1 - 6e-24 83.5 0.1 5.9e-11 41.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain hSH3 PF14603.6 EFC42910.1 - 0.00046 20.6 0.0 0.82 10.1 0.0 2.7 1 1 1 2 2 2 2 Helically-extended SH3 domain SH3_10 PF17902.1 EFC42910.1 - 0.0066 16.5 0.1 3.8 7.7 0.0 2.6 2 0 0 2 2 2 2 SH3 domain APG6_N PF17675.1 EFC42910.1 - 0.022 15.3 9.9 0.022 15.3 9.9 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region Bromo_TP PF07524.13 EFC42910.1 - 0.099 12.7 0.1 0.35 10.9 0.0 2.0 2 0 0 2 2 1 0 Bromodomain associated S-l_SbsC_C PF18316.1 EFC42910.1 - 0.29 11.6 0.1 0.29 11.6 0.1 3.5 3 1 1 4 4 3 0 S-layer protein SbsC C-terminal domain Seryl_tRNA_N PF02403.22 EFC42910.1 - 3 8.1 18.2 1.3 9.3 8.0 3.4 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain CENP-H PF05837.12 EFC42910.1 - 5.4 7.5 15.1 2.7 8.4 11.8 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF4168 PF13767.6 EFC42910.1 - 5.5 8.2 12.4 95 4.3 6.2 4.0 3 1 1 4 4 4 0 Domain of unknown function (DUF4168) ESM4 PF15952.5 EFC42910.1 - 9 6.7 12.5 21 5.5 12.5 1.6 1 1 0 1 1 1 0 Enhancer of split M4 family Atg14 PF10186.9 EFC42910.1 - 9.8 5.1 15.9 30 3.6 15.6 1.8 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 PPV_E1_N PF00524.18 EFC42911.1 - 2.6 8.5 14.4 2.5 8.5 9.6 2.9 2 1 0 2 2 2 0 E1 Protein, N terminal domain zf-CCCH PF00642.24 EFC42912.1 - 6.4e-05 22.7 20.6 0.00018 21.4 2.2 3.9 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFC42912.1 - 7.2e-05 22.7 5.8 7.2e-05 22.7 5.8 4.1 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH_4 PF18044.1 EFC42912.1 - 0.00012 21.7 2.9 0.00012 21.7 2.9 4.0 3 1 0 3 3 3 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EFC42912.1 - 0.0038 17.6 29.2 0.15 12.6 7.6 3.9 3 0 0 3 3 3 3 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EFC42912.1 - 0.14 12.9 15.9 0.053 14.2 4.0 3.7 1 1 2 3 3 3 0 Torus domain zf-CCCH_3 PF15663.5 EFC42912.1 - 0.39 11.0 12.3 1 9.6 0.2 3.1 2 1 0 2 2 2 0 Zinc-finger containing family TEX12 PF15219.6 EFC42913.1 - 0.009 16.3 0.7 2.3 8.6 0.0 3.3 3 0 0 3 3 3 2 Testis-expressed 12 Dak2 PF02734.17 EFC42913.1 - 0.18 11.7 0.1 0.34 10.8 0.1 1.4 1 0 0 1 1 1 0 DAK2 domain LRR_6 PF13516.6 EFC42914.1 - 1.5e-15 55.8 21.8 4.1e-05 23.3 0.2 6.0 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 EFC42914.1 - 4.9e-07 30.0 13.1 0.0037 17.6 4.0 4.6 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC42914.1 - 0.0038 17.6 1.3 88 4.3 0.1 5.5 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC42914.1 - 0.045 13.5 17.8 2.8 7.8 10.0 4.5 1 1 2 3 3 3 0 Leucine rich repeat cNMP_binding PF00027.29 EFC42915.1 - 8.7e-16 57.8 0.0 1.4e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 EFC42915.1 - 7.5e-13 48.3 14.9 1.1e-12 47.7 14.9 1.2 1 0 0 1 1 1 1 Ion transport protein Pex14_N PF04695.13 EFC42915.1 - 0.0014 19.3 6.2 0.0014 19.3 6.2 3.0 3 0 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region GP3_package PF16677.5 EFC42915.1 - 0.0039 17.3 0.1 0.37 11.0 0.0 2.6 2 1 0 2 2 2 1 DNA-packaging protein gp3 Mt_ATP-synt_B PF05405.14 EFC42915.1 - 0.12 12.0 0.9 0.73 9.4 0.0 2.4 3 0 0 3 3 3 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Ion_trans_2 PF07885.16 EFC42915.1 - 7.1 6.7 9.9 0.13 12.3 2.9 1.8 2 0 0 2 2 2 0 Ion channel Pro-rich PF15240.6 EFC42915.1 - 7.6 6.8 55.8 0.084 13.2 29.9 2.1 2 0 0 2 2 2 0 Proline-rich UAA PF08449.11 EFC42916.1 - 7e-29 101.0 10.2 4.2e-25 88.6 5.4 2.5 2 1 1 3 3 3 2 UAA transporter family EamA PF00892.20 EFC42916.1 - 0.00026 21.2 7.2 0.00057 20.1 3.8 2.3 2 0 0 2 2 2 1 EamA-like transporter family CRT-like PF08627.10 EFC42916.1 - 0.00038 19.5 4.1 0.00053 19.0 4.1 1.3 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like GTP_cyclohydroI PF01227.22 EFC42918.1 - 2.1e-07 30.5 0.0 2.9e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I GTP_cyclohydroI PF01227.22 EFC42919.1 - 5e-56 189.0 1.1 5.5e-56 188.8 1.1 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 EFC42919.1 - 6.1e-05 23.1 0.0 8e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 QueF-like protein DUF2294 PF10057.9 EFC42919.1 - 0.017 15.2 1.4 0.03 14.5 1.4 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) EIF_2_alpha PF07541.12 EFC42919.1 - 0.16 12.1 0.4 0.28 11.3 0.4 1.4 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit YflT PF11181.8 EFC42920.1 - 0.00046 20.6 0.8 0.0034 17.8 1.5 1.9 2 0 0 2 2 2 1 Heat induced stress protein YflT DUF1690 PF07956.11 EFC42920.1 - 0.13 12.7 9.8 0.19 12.2 9.8 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) TFIIE_beta PF02186.15 EFC42920.1 - 1.7 9.0 6.3 1.9 8.8 3.0 2.4 1 1 2 3 3 3 0 TFIIE beta subunit core domain MAS20 PF02064.15 EFC42920.1 - 2.2 8.4 8.5 2.5 8.2 6.9 1.8 2 0 0 2 2 2 0 MAS20 protein import receptor Ribosomal_S13 PF00416.22 EFC42921.1 - 1.8e-47 160.9 0.7 2.1e-47 160.7 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 DUF2746 PF10874.8 EFC42921.1 - 0.03 14.8 0.0 0.045 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) HATPase_c_3 PF13589.6 EFC42921.1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase T5orf172 PF10544.9 EFC42922.1 - 0.094 13.3 0.8 0.32 11.5 0.0 2.3 3 0 0 3 3 3 0 T5orf172 domain cwf21 PF08312.12 EFC42923.1 - 0.00046 20.3 5.4 0.0013 18.9 5.4 1.8 1 0 0 1 1 1 1 cwf21 domain UMPH-1 PF05822.12 EFC42923.1 - 0.17 11.4 4.5 0.074 12.6 2.1 1.6 1 1 1 2 2 2 0 Pyrimidine 5'-nucleotidase (UMPH-1) CALM_bind PF16025.5 EFC42923.1 - 0.83 10.2 11.0 0.5 10.9 0.7 2.7 3 0 0 3 3 3 0 Calcium-dependent calmodulin binding SAD_SRA PF02182.17 EFC42924.1 - 1.7e-25 89.5 0.0 1.7e-25 89.5 0.0 2.5 3 0 0 3 3 3 1 SAD/SRA domain R3H PF01424.22 EFC42924.1 - 1.7e-08 34.3 1.4 3.1e-08 33.5 0.1 2.2 2 0 0 2 2 2 1 R3H domain zf-CCCH PF00642.24 EFC42925.1 - 1.6e-19 69.3 15.8 6.1e-13 48.3 4.0 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFC42925.1 - 1.3e-07 31.5 4.2 1.3e-07 31.5 4.2 2.5 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFC42925.1 - 7e-06 25.7 15.7 9.5e-06 25.3 1.6 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 EFC42925.1 - 0.0083 16.6 0.3 0.0083 16.6 0.3 2.6 2 0 0 2 2 2 1 RNA-binding, Nab2-type zinc finger Trm112p PF03966.16 EFC42926.1 - 5.7e-10 39.6 0.3 8.2e-10 39.1 0.3 1.2 1 0 0 1 1 1 1 Trm112p-like protein Peptidase_M8 PF01457.16 EFC42927.1 - 8.3e-59 199.6 12.0 2.1e-58 198.3 12.0 1.6 1 1 0 1 1 1 1 Leishmanolysin DUF4200 PF13863.6 EFC42927.1 - 1e-28 100.1 22.7 1e-28 100.1 22.7 4.0 3 2 1 4 4 4 1 Domain of unknown function (DUF4200) DUF4246 PF14033.6 EFC42928.1 - 1.3e-46 159.7 18.7 1.7e-24 86.8 15.2 3.8 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) ORC6 PF05460.13 EFC42928.1 - 0.0029 16.9 1.0 0.0042 16.4 1.0 1.3 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) YtxH PF12732.7 EFC42928.1 - 0.11 13.1 0.1 3.3 8.3 0.0 2.7 2 0 0 2 2 2 0 YtxH-like protein Adaptin_binding PF10199.9 EFC42928.1 - 0.65 10.6 6.8 3 8.5 6.8 2.1 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Mem_trans PF03547.18 EFC42929.1 - 5.5e-18 64.5 27.2 6.5e-09 34.7 7.0 3.3 2 1 1 3 3 3 3 Membrane transport protein Cor1 PF04803.12 EFC42929.1 - 3.2 8.0 4.5 3.5 7.8 1.9 2.1 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region RWP-RK PF02042.15 EFC42930.1 - 9.5e-08 31.9 0.2 3.1e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 RWP-RK domain HTH_Crp_2 PF13545.6 EFC42930.1 - 0.1 12.6 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_23 PF13384.6 EFC42930.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 EFC42930.1 - 0.18 11.5 0.1 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 G_glu_transpept PF01019.21 EFC42931.1 - 3.6e-137 458.2 0.0 1.3e-94 317.9 0.0 2.0 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase RWP-RK PF02042.15 EFC42932.1 - 7.5e-05 22.6 0.0 0.00017 21.5 0.0 1.6 1 0 0 1 1 1 1 RWP-RK domain Sigma70_r4_2 PF08281.12 EFC42932.1 - 0.014 15.0 0.0 0.029 14.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_Tnp_4 PF13613.6 EFC42932.1 - 0.031 14.0 0.0 0.072 12.8 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease HTH_23 PF13384.6 EFC42932.1 - 0.089 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_Tnp_ISL3 PF13542.6 EFC42932.1 - 0.16 11.4 0.0 0.36 10.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 RCC1 PF00415.18 EFC42933.1 - 0.00084 19.9 0.0 0.028 15.0 0.0 3.2 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat CH PF00307.31 EFC42934.1 - 4.5e-08 33.2 0.1 4.5e-08 33.2 0.1 3.1 3 0 0 3 3 3 1 Calponin homology (CH) domain Spc7 PF08317.11 EFC42934.1 - 0.031 13.2 20.9 0.07 12.0 20.9 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Polysacc_deac_2 PF04748.13 EFC42934.1 - 0.047 12.9 2.7 0.11 11.7 2.7 1.6 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase WEMBL PF05701.11 EFC42934.1 - 0.076 11.7 20.0 0.14 10.8 20.0 1.4 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF489 PF04356.12 EFC42934.1 - 0.99 9.4 8.6 0.86 9.6 6.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Glyco_hydro_1 PF00232.18 EFC42934.1 - 1.4 7.2 5.3 2.5 6.4 5.3 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Atg14 PF10186.9 EFC42934.1 - 5.2 6.1 26.9 0.07 12.2 17.8 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 MPS2 PF17060.5 EFC42934.1 - 7.2 5.8 19.1 29 3.8 19.1 1.9 1 1 0 1 1 1 0 Monopolar spindle protein 2 DEAD PF00270.29 EFC42935.1 - 2e-20 73.3 0.0 7.7e-20 71.4 0.0 2.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC42935.1 - 8e-15 55.3 0.3 1.1e-13 51.6 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC42935.1 - 6.9e-06 26.4 0.0 3.7e-05 24.0 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain T2SSE PF00437.20 EFC42935.1 - 0.011 14.8 0.0 0.023 13.8 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Suc_Fer-like PF06999.12 EFC42936.1 - 5.7e-27 94.9 0.1 7.9e-27 94.4 0.1 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like RhoGEF PF00621.20 EFC42937.1 - 2.7e-40 138.5 2.0 2.7e-40 138.5 2.0 2.3 2 0 0 2 2 2 1 RhoGEF domain Cupin_4 PF08007.12 EFC42938.1 - 7.1e-45 153.8 1.0 1.3e-44 153.0 0.7 1.6 1 1 1 2 2 2 1 Cupin superfamily protein Cupin_8 PF13621.6 EFC42938.1 - 1e-08 35.3 1.1 5.4e-07 29.6 0.0 3.0 2 1 0 2 2 2 1 Cupin-like domain Cupin_1 PF00190.22 EFC42938.1 - 0.007 16.0 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 Cupin JmjC PF02373.22 EFC42938.1 - 0.011 16.1 0.0 0.047 14.1 0.0 2.1 1 0 0 1 1 1 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 EFC42938.1 - 0.017 14.8 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 0 Cupin domain ARD PF03079.14 EFC42938.1 - 0.58 10.3 4.5 0.98 9.6 0.0 3.0 2 1 1 3 3 3 0 ARD/ARD' family TPR_1 PF00515.28 EFC42940.1 - 7.2e-11 41.4 7.0 0.0018 18.0 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC42940.1 - 7.6e-10 38.1 5.0 0.0015 18.5 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC42940.1 - 1.8e-06 27.7 5.8 0.17 12.2 0.0 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC42940.1 - 0.00095 19.6 0.2 0.0035 17.8 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC42940.1 - 0.0013 18.7 0.1 0.13 12.3 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC42940.1 - 0.0018 18.8 0.3 1.3 9.8 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC42940.1 - 0.006 16.9 0.6 1.1 9.6 0.2 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC42940.1 - 0.014 16.0 0.0 0.36 11.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC42940.1 - 0.018 15.2 4.8 1.2 9.5 0.3 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC42940.1 - 0.019 15.3 3.1 9.8 6.8 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC42940.1 - 0.051 13.6 3.8 0.94 9.5 0.4 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SDA1 PF05285.12 EFC42940.1 - 6.3 6.1 22.1 9.7 5.5 22.1 1.3 1 0 0 1 1 1 0 SDA1 Dapper PF15268.6 EFC42941.1 - 0.08 11.8 29.2 0.11 11.3 29.2 1.1 1 0 0 1 1 1 0 Dapper RR_TM4-6 PF06459.12 EFC42941.1 - 0.081 12.7 35.5 0.24 11.2 35.5 1.9 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TPR_17 PF13431.6 EFC42941.1 - 0.12 12.8 0.2 0.35 11.3 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Presenilin PF01080.17 EFC42941.1 - 0.16 10.7 20.9 0.26 10.0 20.9 1.4 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 EFC42941.1 - 0.31 11.3 32.3 0.84 9.9 32.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Hid1 PF12722.7 EFC42941.1 - 0.34 9.0 21.0 0.53 8.4 21.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 EFC42941.1 - 0.7 8.1 34.6 1 7.6 34.6 1.1 1 0 0 1 1 1 0 CDC45-like protein LicD PF04991.13 EFC42941.1 - 0.71 10.0 24.9 2.7 8.1 24.9 2.0 1 0 0 1 1 1 0 LicD family Zip PF02535.22 EFC42941.1 - 5.3 6.2 18.9 9.8 5.3 18.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4551 PF15087.6 EFC42941.1 - 5.6 5.7 23.2 8.7 5.0 23.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Peptidase_S10 PF00450.22 EFC42942.1 - 2e-99 333.8 12.9 3.6e-99 333.0 12.9 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase BPL_N PF09825.9 EFC42943.1 - 2.1e-21 76.4 0.4 1.6e-12 47.2 0.5 2.0 1 1 1 2 2 2 2 Biotin-protein ligase, N terminal DJ-1_PfpI PF01965.24 EFC42943.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EFC42943.1 - 0.0037 16.9 0.0 0.005 16.5 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 EFC42943.1 - 0.0074 16.1 0.0 0.009 15.8 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Synaptobrevin PF00957.21 EFC42944.1 - 1.2e-15 57.1 2.6 2.6e-15 56.0 2.6 1.6 1 0 0 1 1 1 1 Synaptobrevin TBCA PF02970.16 EFC42944.1 - 0.068 13.5 2.5 0.16 12.3 2.5 1.6 1 0 0 1 1 1 0 Tubulin binding cofactor A Ins134_P3_kin PF05770.11 EFC42944.1 - 0.084 12.4 0.9 0.12 11.8 0.9 1.4 1 1 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain DUF848 PF05852.11 EFC42944.1 - 0.17 12.0 3.6 0.25 11.4 3.4 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) G8 PF10162.9 EFC42945.1 - 5.1e-22 78.3 0.6 1.1e-21 77.1 0.6 1.6 1 0 0 1 1 1 1 G8 domain CHRD PF07452.12 EFC42945.1 - 0.00026 21.9 0.8 0.006 17.5 0.0 2.7 2 0 0 2 2 2 1 CHRD domain Beta_helix PF13229.6 EFC42945.1 - 0.0085 16.0 20.0 0.072 12.9 0.0 4.4 4 1 1 5 5 5 3 Right handed beta helix region CAF1 PF04857.20 EFC42945.1 - 0.12 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 CAF1 family ribonuclease Prion PF00377.18 EFC42946.1 - 0.00035 20.4 0.4 0.0011 18.8 0.4 1.8 1 0 0 1 1 1 1 Prion/Doppel alpha-helical domain DUF4050 PF13259.6 EFC42947.1 - 0.13 12.5 5.3 0.2 12.0 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Hamartin PF04388.12 EFC42947.1 - 2 7.0 9.7 1.9 7.0 9.7 1.1 1 0 0 1 1 1 0 Hamartin protein ICA69 PF04629.14 EFC42947.1 - 9.9 6.4 11.6 13 6.0 11.6 1.1 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain Bax1-I PF01027.20 EFC42948.1 - 8.7e-26 91.0 27.5 1.1e-25 90.8 27.5 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Kinesin PF00225.23 EFC42949.1 - 1.8e-17 63.3 0.0 1.8e-17 63.3 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain PP_kinase_C PF13090.6 EFC42949.1 - 0.26 10.7 2.7 3.3 7.2 0.0 2.9 3 0 0 3 3 3 0 Polyphosphate kinase C-terminal domain 2 zf-RING_2 PF13639.6 EFC42950.1 - 1e-07 32.2 7.8 4.5e-07 30.1 4.1 2.5 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EFC42950.1 - 2.1e-07 30.6 3.5 2.1e-07 30.6 3.5 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 EFC42950.1 - 5.4e-05 23.1 2.7 5.4e-05 23.1 2.7 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFC42950.1 - 5.4e-05 23.1 7.3 7e-05 22.7 3.8 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFC42950.1 - 0.0018 18.1 7.7 0.002 18.0 3.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC42950.1 - 0.0028 17.5 6.2 0.01 15.7 2.8 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EFC42950.1 - 0.017 14.7 2.8 0.017 14.7 2.8 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 EFC42950.1 - 0.028 14.7 5.4 0.029 14.7 2.4 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain RINGv PF12906.7 EFC42950.1 - 0.22 11.7 1.6 0.71 10.0 1.6 1.9 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 EFC42950.1 - 0.29 11.3 3.0 0.3 11.2 1.1 1.9 2 0 0 2 2 2 0 KIAA1045 RING finger zf-RING_6 PF14835.6 EFC42950.1 - 0.5 10.3 2.9 0.4 10.6 0.6 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 EFC42950.1 - 1.8 8.5 5.1 3.6 7.5 1.8 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cucumo_coat PF00760.18 EFC42951.1 - 0.011 15.4 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Cucumovirus coat protein SBDS PF01172.18 EFC42952.1 - 2.3e-20 72.4 1.2 3.8e-20 71.8 1.2 1.4 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 EFC42952.1 - 9.2e-17 61.1 0.2 1.7e-16 60.3 0.2 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain Phage_TAC_5 PF08890.11 EFC42952.1 - 0.044 13.8 0.9 0.4 10.7 0.2 2.5 2 1 0 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC DUF1949 PF09186.11 EFC42952.1 - 0.083 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1949) Pox_A22 PF04848.13 EFC42953.1 - 8.9e-05 22.6 0.5 1.2e+02 2.8 0.0 5.8 1 1 2 6 6 6 0 Poxvirus A22 protein Rho_RNA_bind PF07497.12 EFC42953.1 - 0.00021 21.1 3.6 23 4.9 0.0 4.9 1 1 4 5 5 5 2 Rho termination factor, RNA-binding domain Urocanase_N PF17391.2 EFC42953.1 - 0.00093 18.9 0.0 22 4.8 0.0 4.2 1 1 3 4 4 4 2 Urocanase N-terminal domain BAP PF06639.11 EFC42953.1 - 0.0037 17.6 8.2 21 5.5 0.1 5.0 1 1 5 6 6 6 3 Basal layer antifungal peptide (BAP) Bax1-I PF01027.20 EFC42954.1 - 2.4e-40 138.6 14.2 2.4e-40 138.6 14.2 1.5 2 0 0 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 Yippee-Mis18 PF03226.14 EFC42955.1 - 1.2e-13 51.2 4.5 1.4e-13 50.9 4.5 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 EFC42955.1 - 2.8e-05 24.3 5.0 3.5e-05 24.0 5.0 1.1 1 0 0 1 1 1 1 C-terminal domain of RIG-I SelR PF01641.18 EFC42955.1 - 0.04 14.0 3.5 0.089 12.9 3.5 1.5 1 1 0 1 1 1 0 SelR domain zf-UBP PF02148.19 EFC42955.1 - 0.06 13.7 5.3 0.14 12.5 5.3 1.6 1 1 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein zf-HIT PF04438.16 EFC42955.1 - 0.12 12.3 0.5 0.12 12.3 0.5 2.3 2 0 0 2 2 2 0 HIT zinc finger Tnp_zf-ribbon_2 PF13842.6 EFC42955.1 - 0.17 12.7 0.7 0.17 12.7 0.7 2.4 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon Ras PF00071.22 EFC42956.1 - 3.2e-20 72.4 0.0 4e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC42956.1 - 3.5e-10 40.2 0.0 5.8e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EFC42956.1 - 0.0029 17.9 0.0 0.0042 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFC42956.1 - 0.013 15.6 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase F_actin_cap_B PF01115.17 EFC42957.1 - 1.4e-94 316.2 0.0 1.6e-94 316.0 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit RCC1_2 PF13540.6 EFC42958.1 - 0.0049 16.6 0.3 0.0049 16.6 0.3 2.3 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC42958.1 - 0.022 15.4 0.0 8.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Mito_carr PF00153.27 EFC42959.1 - 1e-42 144.0 1.2 9.2e-21 73.6 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF1430 PF07242.11 EFC42959.1 - 0.09 13.0 0.6 0.16 12.3 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) NUDIX PF00293.28 EFC42960.1 - 1.3e-08 35.0 0.1 2.1e-08 34.3 0.1 1.5 1 1 0 1 1 1 1 NUDIX domain Plasmod_MYXSPDY PF07981.11 EFC42960.1 - 0.43 10.6 2.8 0.99 9.5 2.8 1.5 1 0 0 1 1 1 0 Plasmodium repeat_MYXSPDY LRR_4 PF12799.7 EFC42961.1 - 0.0054 17.1 18.3 4.2 7.9 0.2 6.1 4 2 2 7 7 7 4 Leucine Rich repeats (2 copies) LMBR1 PF04791.16 EFC42962.1 - 1.2e-26 93.7 43.6 2.4e-20 72.9 16.6 2.1 1 1 1 2 2 2 2 LMBR1-like membrane protein CDC50 PF03381.15 EFC42962.1 - 0.034 13.7 0.0 0.034 13.7 0.0 2.1 2 0 0 2 2 2 0 LEM3 (ligand-effect modulator 3) family / CDC50 family ZapB PF06005.12 EFC42963.1 - 0.019 15.4 9.0 0.019 15.4 9.0 5.9 5 1 1 6 6 6 0 Cell division protein ZapB WXG100 PF06013.12 EFC42963.1 - 5.5 7.3 8.4 2.9 8.2 0.3 3.8 4 0 0 4 4 4 0 Proteins of 100 residues with WXG Ank_2 PF12796.7 EFC42964.1 - 0.00026 21.5 0.0 0.00071 20.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC42964.1 - 0.014 15.9 0.0 4.6 7.9 0.0 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC42964.1 - 0.12 13.0 0.0 5.5 7.9 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat Casein PF00363.18 EFC42965.1 - 0.021 15.2 1.7 0.039 14.3 1.0 1.8 1 1 0 1 1 1 0 Casein LPP PF04728.13 EFC42965.1 - 0.029 14.8 6.2 0.37 11.2 0.3 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DUF1515 PF07439.11 EFC42965.1 - 0.032 14.2 7.9 0.073 13.1 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF948 PF06103.11 EFC42965.1 - 0.083 13.2 1.5 5.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 EFC42965.1 - 0.18 11.3 20.0 0.018 14.6 10.8 2.0 1 1 1 2 2 2 0 Intermediate filament protein NPV_P10 PF05531.12 EFC42965.1 - 0.23 12.0 6.3 1.9 9.0 0.8 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 EFC42965.1 - 0.56 10.3 5.8 2.3 8.3 0.9 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF724 PF05266.14 EFC42965.1 - 1 9.2 17.7 0.76 9.6 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Exonuc_VII_L PF02601.15 EFC42965.1 - 1.1 8.7 13.4 1.9 7.9 13.4 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit TMCO5 PF14992.6 EFC42965.1 - 1.3 8.5 17.2 2 7.9 17.2 1.3 1 0 0 1 1 1 0 TMCO5 family GTA_holin_3TM PF11351.8 EFC42965.1 - 1.7 9.2 5.6 0.66 10.5 2.6 1.8 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release Spc7 PF08317.11 EFC42965.1 - 2.3 7.0 21.3 28 3.5 12.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein YabA PF06156.13 EFC42965.1 - 2.4 8.9 15.0 28 5.4 0.4 2.5 1 1 1 2 2 2 0 Initiation control protein YabA FlaC_arch PF05377.11 EFC42965.1 - 8.1 6.9 8.7 11 6.5 0.4 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF445 PF04286.12 EFC42966.1 - 0.0066 16.3 13.1 0.0066 16.3 13.1 4.2 2 2 0 3 3 3 1 Protein of unknown function (DUF445) DCB PF16213.5 EFC42967.1 - 0.0096 15.6 1.3 0.1 12.2 0.4 2.5 1 1 1 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 His_kinase PF06580.13 EFC42967.1 - 0.29 11.5 3.6 0.31 11.4 0.3 2.8 3 0 0 3 3 3 0 Histidine kinase Mucin PF01456.17 EFC42968.1 - 4 7.4 14.6 0.22 11.5 8.6 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2838 PF10998.8 EFC42969.1 - 1.4e-35 121.9 13.0 1.4e-35 121.9 13.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) SAM_1 PF00536.30 EFC42970.1 - 3.7e-06 27.3 1.8 9e-06 26.0 1.8 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC42970.1 - 5.4e-05 23.2 1.6 0.00017 21.7 1.6 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kelch_4 PF13418.6 EFC42972.1 - 9.4e-12 44.8 2.1 0.02 14.9 0.0 6.5 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC42972.1 - 2.6e-11 43.4 10.3 0.00094 19.4 0.1 6.5 6 1 1 7 7 7 3 Kelch motif Kelch_3 PF13415.6 EFC42972.1 - 1.9e-08 34.4 1.2 0.0022 18.2 0.0 5.6 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC42972.1 - 8.2e-08 32.1 0.3 0.11 12.6 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 EFC42972.1 - 0.00016 21.1 9.2 1.3 8.6 0.0 4.6 4 0 0 4 4 4 3 Kelch motif EphA2_TM PF14575.6 EFC42973.1 - 0.066 14.1 0.0 7.7 7.5 0.0 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SP_C-Propep PF08999.10 EFC42973.1 - 3.8 7.4 5.4 12 5.7 1.9 2.2 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide Tad PF13400.6 EFC42973.1 - 7.2 7.0 7.6 34 4.9 0.0 2.1 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like Zn_clus PF00172.18 EFC42974.1 - 4.3e-08 33.1 12.2 9.5e-08 32.0 12.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SYCP2_ARLD PF18581.1 EFC42974.1 - 0.024 14.6 0.1 0.1 12.6 0.1 2.2 2 0 0 2 2 2 0 Synaptonemal complex 2 armadillo-repeat-like domain ABC_membrane_2 PF06472.15 EFC42975.1 - 2.3e-66 224.0 0.1 2.8e-65 220.4 0.8 2.0 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFC42975.1 - 9.5e-20 71.5 0.0 4.8e-19 69.2 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 EFC42975.1 - 5.1e-07 29.8 0.2 4.9e-05 23.3 0.1 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane PF00664.23 EFC42975.1 - 1.8e-06 27.8 1.8 3.5e-06 26.9 1.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_23 PF13476.6 EFC42975.1 - 0.00034 21.2 2.9 0.0017 18.9 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFC42975.1 - 0.00044 19.8 0.0 0.00098 18.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_27 PF13514.6 EFC42975.1 - 0.014 15.0 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC42975.1 - 0.02 14.6 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EFC42975.1 - 0.037 13.5 0.2 0.17 11.3 0.2 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFC42975.1 - 0.051 13.8 0.0 0.27 11.5 0.0 2.2 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EFC42975.1 - 0.089 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase IstB_IS21 PF01695.17 EFC42975.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Prp19 PF08606.11 EFC42976.1 - 3.5e-33 113.4 0.5 9.3e-33 112.0 0.5 1.7 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 EFC42976.1 - 2.5e-23 81.9 10.4 2e-09 37.9 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC42976.1 - 7.9e-11 42.1 0.1 0.0017 18.6 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain zf-Nse PF11789.8 EFC42976.1 - 1.3e-05 24.9 1.8 2.2e-05 24.2 0.1 2.3 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit Ge1_WD40 PF16529.5 EFC42976.1 - 0.00015 20.8 1.4 2.7 6.9 0.0 3.4 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EFC42976.1 - 0.006 15.2 0.0 0.062 11.8 0.0 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain PEPcase PF00311.17 EFC42976.1 - 0.38 8.8 3.4 0.53 8.3 3.4 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Actin PF00022.19 EFC42977.1 - 6.4e-70 235.8 0.1 1.8e-68 231.1 0.1 2.0 1 1 0 1 1 1 1 Actin Penicil_amidase PF01804.18 EFC42979.1 - 1.8e-178 595.6 0.1 2.5e-178 595.2 0.1 1.0 1 0 0 1 1 1 1 Penicillin amidase PBP1_TM PF14812.6 EFC42979.1 - 0.00068 20.0 0.2 0.0013 19.1 0.2 1.4 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Fructosamin_kin PF03881.14 EFC42979.1 - 0.091 11.9 1.4 0.23 10.6 0.0 2.2 3 1 0 3 3 3 0 Fructosamine kinase FAM176 PF14851.6 EFC42979.1 - 0.13 11.9 2.9 0.071 12.8 0.5 1.8 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 EFC42979.1 - 0.5 10.8 7.9 1 9.8 7.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 EFC42979.1 - 0.54 8.3 5.5 0.8 7.7 5.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 EFC42979.1 - 0.84 8.9 10.5 1.5 8.1 10.5 1.3 1 0 0 1 1 1 0 NOA36 protein S-antigen PF05756.11 EFC42979.1 - 0.93 9.9 6.0 0.31 11.4 2.8 1.8 2 0 0 2 2 2 0 S-antigen protein DUF4611 PF15387.6 EFC42979.1 - 1.3 9.3 6.1 3.2 8.0 6.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF5623 PF18536.1 EFC42980.1 - 0.18 12.1 4.1 7.2 6.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5623) RNA_pol_Rpb1_R PF05001.13 EFC42981.1 - 0.029 14.7 52.2 0.11 12.8 5.8 5.6 3 2 1 4 4 4 0 RNA polymerase Rpb1 C-terminal repeat WH2 PF02205.20 EFC42982.1 - 3.5e-07 29.9 0.1 3e-06 26.8 0.1 2.6 2 0 0 2 2 2 1 WH2 motif ArgoMid PF16487.5 EFC42982.1 - 0.017 15.4 1.0 0.051 13.8 0.9 1.8 1 1 1 2 2 2 0 Mid domain of argonaute Aa_trans PF01490.18 EFC42982.1 - 0.073 11.8 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein FapA PF03961.13 EFC42982.1 - 0.1 11.2 8.1 0.12 10.9 8.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A LRR_4 PF12799.7 EFC42986.1 - 1.4e-21 76.2 31.3 0.00026 21.3 0.4 9.4 3 1 5 10 10 10 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC42986.1 - 4.5e-20 69.9 31.4 0.00078 19.3 0.2 12.1 12 0 0 12 12 12 6 Leucine Rich repeat LRR_8 PF13855.6 EFC42986.1 - 2.8e-15 55.8 24.1 2.8e-06 27.0 0.6 7.0 4 2 2 6 6 6 5 Leucine rich repeat LRR_1 PF00560.33 EFC42986.1 - 1.8e-06 27.7 19.3 1.8 9.4 0.0 8.9 7 2 0 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC42986.1 - 6.3e-05 22.5 16.3 0.0016 18.0 1.6 4.0 1 1 3 4 4 4 3 Leucine-rich repeat LRR_2 PF07723.13 EFC42986.1 - 0.11 13.2 6.2 71 4.3 0.0 5.6 5 0 0 5 5 5 0 Leucine Rich Repeat ADH_zinc_N_2 PF13602.6 EFC42987.1 - 6e-12 46.8 0.0 1.6e-11 45.4 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC42987.1 - 1.8e-09 37.5 0.1 1.1e-08 34.9 0.1 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC42987.1 - 1.6e-07 31.4 0.0 4.4e-07 29.9 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EFC42987.1 - 0.0037 17.1 0.0 0.0057 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) TA0956 PF11513.8 EFC42987.1 - 0.11 12.7 0.1 0.28 11.4 0.1 1.7 1 0 0 1 1 1 0 Thermoplasma acidophilum protein TA0956 PP2C PF00481.21 EFC42988.1 - 8.9e-37 127.1 0.2 6.2e-35 121.1 0.1 2.0 1 1 1 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFC42988.1 - 0.0013 18.4 0.0 0.0045 16.7 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Suf PF05843.14 EFC42989.1 - 0.097 12.6 11.1 0.14 12.1 11.1 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) ADK PF00406.22 EFC42990.1 - 2.6e-44 151.0 0.0 3.5e-44 150.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFC42990.1 - 2.2e-23 83.2 0.3 6.4e-23 81.7 0.1 1.8 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 EFC42990.1 - 2.5e-12 46.5 1.8 4.1e-12 45.9 1.8 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EFC42990.1 - 0.0024 18.0 0.0 0.0037 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC42990.1 - 0.0028 18.2 0.0 0.0043 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DZR PF12773.7 EFC42990.1 - 0.077 13.0 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zeta_toxin PF06414.12 EFC42990.1 - 0.091 12.0 0.1 0.15 11.3 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 EFC42990.1 - 0.11 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf_C2H2_13 PF18508.1 EFC42990.1 - 0.19 11.3 0.4 2.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Zinc finger domain AAA_28 PF13521.6 EFC42990.1 - 0.2 11.9 0.0 0.29 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain zf-IS66 PF13005.7 EFC42990.1 - 0.35 11.3 1.5 21 5.6 0.3 2.5 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 DUF2358 PF10184.9 EFC42991.1 - 0.0049 17.1 0.8 0.029 14.6 0.6 2.0 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2358) SnoaL_2 PF12680.7 EFC42991.1 - 0.034 14.8 0.0 0.053 14.2 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain MFS_1 PF07690.16 EFC42992.1 - 4e-15 55.6 51.8 4.9e-15 55.3 42.0 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_3 PF05977.13 EFC42992.1 - 8.3e-15 54.2 11.0 1.8e-14 53.0 4.7 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 EFC42992.1 - 2.5e-05 23.3 19.5 9.9e-05 21.4 9.5 2.5 2 1 0 2 2 2 2 MFS_1 like family Metallophos PF00149.28 EFC42993.1 - 1.7e-06 28.7 0.3 3.5e-06 27.7 0.3 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF3108 PF11306.8 EFC42993.1 - 0.033 14.2 0.3 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3108) Pkinase PF00069.25 EFC42994.1 - 7.4e-34 117.3 0.6 1.9e-33 115.9 0.6 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC42994.1 - 4.8e-27 94.9 0.2 1e-26 93.8 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Shisa PF13908.6 EFC42994.1 - 1.4e-05 25.4 0.8 1.4e-05 25.4 0.8 4.7 3 1 1 4 4 2 1 Wnt and FGF inhibitory regulator Pkinase_fungal PF17667.1 EFC42994.1 - 1.7e-05 23.8 0.0 1.7e-05 23.8 0.0 3.9 3 1 0 3 3 2 1 Fungal protein kinase F-box PF00646.33 EFC42994.1 - 4.2e-05 23.3 0.0 0.00013 21.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain GPS PF01825.21 EFC42994.1 - 6.9e-05 23.3 0.4 0.00018 22.0 0.4 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif TMEM154 PF15102.6 EFC42994.1 - 0.0012 18.8 0.9 0.0012 18.8 0.9 5.7 3 1 1 4 4 2 1 TMEM154 protein family XPA_C PF05181.12 EFC42994.1 - 0.0034 17.3 0.0 0.014 15.4 0.0 2.1 1 0 0 1 1 1 1 XPA protein C-terminus ODV-E18 PF10717.9 EFC42994.1 - 0.0078 16.1 2.3 0.048 13.5 2.3 2.4 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 EphA2_TM PF14575.6 EFC42994.1 - 0.014 16.2 0.4 0.014 16.2 0.4 3.5 3 1 0 3 3 1 0 Ephrin type-A receptor 2 transmembrane domain F-box-like PF12937.7 EFC42994.1 - 0.019 14.8 0.5 0.046 13.6 0.5 1.7 1 0 0 1 1 1 0 F-box-like Kdo PF06293.14 EFC42994.1 - 0.07 12.5 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4834 PF16118.5 EFC42994.1 - 0.21 12.6 0.1 0.21 12.6 0.1 5.5 3 1 1 4 4 2 0 Domain of unknown function (DUF4834) SIT PF15330.6 EFC42994.1 - 0.44 11.0 0.0 0.44 11.0 0.0 3.3 3 0 0 3 3 2 0 SHP2-interacting transmembrane adaptor protein, SIT p450 PF00067.22 EFC42996.1 - 6.4e-79 265.8 0.1 8.2e-79 265.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PH PF00169.29 EFC42997.1 - 9.1e-09 35.8 0.1 1.6e-08 35.0 0.1 1.4 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 EFC42997.1 - 0.0014 18.9 0.0 0.002 18.5 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 EFC42997.1 - 0.01 15.9 0.3 0.031 14.4 0.1 1.8 1 1 0 2 2 2 0 PH domain RCC1 PF00415.18 EFC42998.1 - 0.031 14.9 0.0 13 6.5 0.0 2.7 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat Vps16_N PF04841.13 EFC42998.1 - 0.38 9.5 3.8 10 4.7 0.1 3.0 2 1 1 3 3 3 0 Vps16, N-terminal region cobW PF02492.19 EFC42999.1 - 1.1e-48 165.2 5.5 2.1e-47 161.0 5.5 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFC42999.1 - 2.7e-21 75.3 0.0 5.5e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EFC42999.1 - 4.4e-05 23.4 0.3 0.33 10.8 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase TsaE PF02367.17 EFC42999.1 - 0.0018 18.2 0.0 0.0053 16.8 0.0 1.7 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFC42999.1 - 0.0044 17.6 1.7 0.033 14.7 0.0 3.0 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 EFC42999.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 EFC42999.1 - 0.028 14.8 0.0 0.12 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 EFC42999.1 - 0.029 14.5 0.0 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC42999.1 - 0.032 14.5 0.1 0.36 11.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFC42999.1 - 0.043 14.3 1.4 0.18 12.3 1.2 2.3 1 1 0 1 1 1 0 ABC transporter MobB PF03205.14 EFC42999.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.6 EFC42999.1 - 0.093 12.8 1.2 0.89 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFC42999.1 - 0.17 11.9 1.0 0.98 9.5 1.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF678 PF05077.12 EFC42999.1 - 0.84 9.8 4.3 0.3 11.2 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF678) AAA_23 PF13476.6 EFC42999.1 - 3.5 8.1 16.1 2.7 8.4 0.1 3.2 3 0 0 3 3 3 0 AAA domain PseudoU_synth_2 PF00849.22 EFC43000.1 - 1.8e-23 83.4 0.2 3e-23 82.7 0.2 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase NIF PF03031.18 EFC43001.1 - 6.3e-51 172.2 0.0 1.6e-50 170.9 0.0 1.7 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EFC43001.1 - 0.19 12.1 0.2 2.7 8.4 0.0 2.5 1 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase TUSC2 PF15000.6 EFC43001.1 - 2.1 8.7 17.8 0.064 13.5 7.5 3.3 2 1 1 3 3 3 0 Tumour suppressor candidate 2 Ferric_reduct PF01794.19 EFC43002.1 - 5.9e-18 65.2 8.5 5.9e-18 65.2 8.5 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DOMON PF03351.17 EFC43002.1 - 1.9e-17 63.7 1.0 1.9e-17 63.7 1.0 2.3 3 0 0 3 3 3 1 DOMON domain NAD_binding_6 PF08030.12 EFC43002.1 - 6.5e-10 39.3 0.4 3.8e-09 36.8 0.0 2.1 2 0 0 2 2 2 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EFC43002.1 - 0.053 14.2 0.0 1.5 9.5 0.0 2.5 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Ferric_reduct PF01794.19 EFC43003.1 - 5.9e-21 74.9 6.8 3.7e-19 69.1 7.5 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 EFC43003.1 - 2e-08 34.5 1.1 3.5e-08 33.7 0.0 1.9 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 EFC43003.1 - 0.00017 21.6 0.1 0.00043 20.4 0.1 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFC43003.1 - 0.18 12.5 0.0 1.2 9.8 0.0 2.2 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain RhoGAP PF00620.27 EFC43004.1 - 1.1e-26 93.5 0.5 4.5e-26 91.5 0.5 2.0 1 1 0 1 1 1 1 RhoGAP domain SOG2 PF10428.9 EFC43004.1 - 0.0039 16.5 20.8 0.0039 16.5 20.8 2.1 2 0 0 2 2 2 1 RAM signalling pathway protein Synaptobrevin PF00957.21 EFC43005.1 - 2.5e-14 52.8 2.4 3.7e-14 52.3 2.4 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFC43005.1 - 1.4e-05 25.0 0.0 2.7e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain DUF1515 PF07439.11 EFC43005.1 - 0.036 14.1 0.7 0.058 13.4 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) HSBP1 PF06825.12 EFC43005.1 - 0.036 13.9 1.2 0.26 11.2 0.8 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Tnp_22_trimer PF17489.2 EFC43005.1 - 1.6 8.7 8.7 0.8 9.7 3.6 2.3 1 1 1 2 2 2 0 L1 transposable element trimerization domain adh_short PF00106.25 EFC43006.1 - 4.8e-17 62.1 0.0 7.6e-11 41.8 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43006.1 - 3.7e-13 49.6 0.0 1.7e-05 24.5 0.0 2.5 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase CDC45 PF02724.14 EFC43006.1 - 0.0096 14.3 14.6 0.015 13.6 14.6 1.2 1 0 0 1 1 1 1 CDC45-like protein F-box-like PF12937.7 EFC43006.1 - 0.048 13.6 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC43006.1 - 0.056 13.3 0.0 0.18 11.7 0.0 1.9 1 0 0 1 1 1 0 F-box domain POTRA_2 PF08479.11 EFC43006.1 - 0.16 11.8 0.0 0.47 10.3 0.0 1.8 1 0 0 1 1 1 0 POTRA domain, ShlB-type TFIIF_alpha PF05793.12 EFC43006.1 - 0.32 9.5 31.4 0.51 8.9 31.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 EFC43006.1 - 1.7 6.6 25.7 3.3 5.7 25.7 1.4 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.10 EFC43006.1 - 2.4 7.4 23.8 3.9 6.7 23.8 1.2 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 EFC43006.1 - 2.5 6.8 6.9 3.7 6.2 6.9 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 EFC43006.1 - 3.7 7.0 6.6 7.8 5.9 6.6 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2201_N PF13203.6 EFC43006.1 - 7.6 6.0 6.2 12 5.4 6.2 1.3 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF4746 PF15928.5 EFC43006.1 - 8.2 5.8 17.4 14 5.0 17.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TPR_1 PF00515.28 EFC43007.1 - 0.00042 20.0 5.0 0.24 11.3 0.5 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC43007.1 - 0.00048 20.0 4.1 1 9.6 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat Rcd1 PF04078.13 EFC43007.1 - 0.0035 16.7 0.1 0.36 10.1 0.0 2.4 2 0 0 2 2 2 1 Cell differentiation family, Rcd1-like TPR_11 PF13414.6 EFC43007.1 - 0.0049 16.5 3.4 9.4 6.0 0.1 4.5 4 0 0 4 4 4 1 TPR repeat ANAPC3 PF12895.7 EFC43007.1 - 0.017 15.3 2.4 5 7.4 0.1 3.8 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC43007.1 - 0.029 14.9 0.1 46 4.6 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC43007.1 - 0.045 14.0 0.5 8.6 6.7 0.1 3.3 2 2 0 2 2 2 0 Tetratricopeptide repeat Com_YlbF PF06133.11 EFC43007.1 - 0.084 13.5 8.0 2.6 8.7 2.7 2.5 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Alkyl_sulf_dimr PF14863.6 EFC43007.1 - 0.098 13.1 0.0 0.31 11.5 0.0 1.9 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_17 PF13431.6 EFC43007.1 - 0.17 12.3 3.2 0.79 10.2 0.3 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC43007.1 - 0.26 12.0 0.8 46 5.0 0.0 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43007.1 - 8.6 6.9 9.3 44 4.6 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat KRTAP PF11759.8 EFC43008.1 - 0.00037 21.0 56.5 1.8e+04 -14.4 56.5 3.1 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 EFC43008.1 - 0.046 13.9 54.2 1.8e+04 -15.3 54.2 3.1 1 1 0 1 1 1 0 Keratin type II head Ank PF00023.30 EFC43009.1 - 0.017 15.6 0.4 0.044 14.2 0.4 1.8 1 0 0 1 1 1 0 Ankyrin repeat SH2_2 PF14633.6 EFC43011.1 - 1.2e-55 188.3 1.1 1.2e-55 188.3 1.1 1.8 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 EFC43011.1 - 6.1e-19 68.3 0.2 1.2e-18 67.4 0.2 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 EFC43011.1 - 5e-16 59.2 3.3 1.3e-15 57.8 3.3 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 YqgF PF14639.6 EFC43011.1 - 1.5e-14 54.0 0.0 4.4e-14 52.5 0.0 1.8 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_9 PF17674.1 EFC43011.1 - 3.7e-08 34.2 1.0 1.6e-07 32.1 1.0 2.3 1 0 0 1 1 1 1 HHH domain Tex_YqgF PF16921.5 EFC43011.1 - 3.1e-07 30.9 0.1 8e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Tex protein YqgF-like domain Tex_N PF09371.10 EFC43011.1 - 6.5e-07 29.2 1.0 1.4e-05 24.9 1.0 2.7 1 1 0 1 1 1 1 Tex-like protein N-terminal domain ELMO_CED12 PF04727.13 EFC43012.1 - 0.052 13.7 0.7 0.13 12.3 0.7 1.7 1 0 0 1 1 1 0 ELMO/CED-12 family Ctf8 PF09696.10 EFC43013.1 - 4.6e-06 27.0 3.2 7.1e-05 23.2 0.2 3.3 2 1 0 2 2 2 1 Ctf8 Arf PF00025.21 EFC43014.1 - 1.6e-78 262.2 0.2 1.9e-78 261.9 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC43014.1 - 3.4e-15 56.3 0.1 4.7e-15 55.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC43014.1 - 1.9e-13 50.4 0.0 2.2e-13 50.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC43014.1 - 3.4e-13 49.5 0.6 4.9e-09 35.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC43014.1 - 6.6e-13 48.5 0.0 8.2e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC43014.1 - 9.3e-10 38.2 0.1 1.2e-09 37.9 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC43014.1 - 1e-05 25.6 0.1 1.5e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 EFC43014.1 - 0.00051 19.4 0.0 0.00062 19.1 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase cobW PF02492.19 EFC43014.1 - 0.0063 16.1 0.4 0.1 12.2 0.0 2.0 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EFC43014.1 - 0.073 13.6 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain MobB PF03205.14 EFC43014.1 - 0.093 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Adeno_GP19K PF04881.13 EFC43015.1 - 0.015 15.3 0.4 0.051 13.6 0.4 1.9 1 0 0 1 1 1 0 Adenovirus GP19K Dopey_N PF04118.14 EFC43016.1 - 7.5e-40 136.9 0.5 1e-39 136.5 0.5 1.1 1 0 0 1 1 1 1 Dopey, N-terminal TRI5 PF06330.11 EFC43016.1 - 0.016 14.1 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) HECA PF15353.6 EFC43016.1 - 0.025 14.8 0.2 0.062 13.5 0.3 1.6 1 1 1 2 2 2 0 Headcase protein family homologue Ribosomal_S5 PF00333.20 EFC43017.1 - 3.5e-16 58.9 0.0 5.7e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFC43017.1 - 1.6e-12 46.7 0.0 3.1e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain PLA2_B PF01735.18 EFC43017.1 - 6e-05 21.6 0.9 0.0001 20.9 0.9 1.3 1 0 0 1 1 1 1 Lysophospholipase catalytic domain DUF413 PF04219.12 EFC43017.1 - 0.046 13.8 0.3 2.2 8.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function, DUF SAS-6_N PF16531.5 EFC43018.1 - 1.2e-17 64.3 1.3 1.2e-17 64.3 1.3 2.4 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal HOOK PF05622.12 EFC43018.1 - 0.59 8.2 78.8 1.8 6.6 78.8 1.6 1 1 0 1 1 1 0 HOOK protein YbfN PF13982.6 EFC43018.1 - 1.3 9.4 8.2 1.1 9.6 3.3 3.1 2 1 1 3 3 3 0 YbfN-like lipoprotein Cnd3 PF12719.7 EFC43019.1 - 1.7e-49 168.6 12.0 1.7e-49 168.6 12.0 2.8 4 1 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 EFC43019.1 - 1.1e-05 25.7 0.0 0.019 15.3 0.0 3.6 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 EFC43019.1 - 3.4e-05 23.7 0.0 7.6 7.1 0.0 6.0 6 0 0 6 6 6 1 HEAT repeat UVR PF02151.19 EFC43019.1 - 0.001 18.7 4.8 0.001 18.7 4.8 3.1 3 0 0 3 3 3 1 UvrB/uvrC motif DUF1386 PF07138.11 EFC43019.1 - 0.01 15.1 1.2 1.2 8.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1386) RIX1 PF08167.12 EFC43019.1 - 0.44 10.3 5.6 0.6 9.8 0.2 3.2 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis F-box PF00646.33 EFC43021.1 - 0.0064 16.3 0.1 0.016 15.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain Phi_1 PF04674.12 EFC43021.1 - 0.058 12.7 0.4 0.093 12.0 0.4 1.2 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region F-box-like PF12937.7 EFC43021.1 - 0.06 13.2 0.1 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 F-box-like DNA_repr_REX1B PF14966.6 EFC43021.1 - 0.13 13.0 4.2 0.2 12.3 0.3 3.0 2 2 1 3 3 3 0 DNA repair REX1-B Nbl1_Borealin_N PF10444.9 EFC43021.1 - 0.67 9.6 4.9 10 5.8 0.2 3.4 4 0 0 4 4 4 0 Nbl1 / Borealin N terminal PdaC PF13739.6 EFC43021.1 - 9.5 7.3 12.9 5.9 7.9 1.1 3.1 2 1 0 3 3 3 0 Deacetylase PdaC Trehalose_PPase PF02358.16 EFC43022.1 - 3.6e-45 153.9 0.0 5.7e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 EFC43022.1 - 1.2e-06 28.4 1.1 1.6e-06 28.0 0.6 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TatD_DNase PF01026.21 EFC43024.1 - 2.2e-51 174.7 0.0 2.5e-51 174.5 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_1 PF01979.20 EFC43024.1 - 0.021 14.1 0.0 0.82 8.9 0.0 2.2 1 1 0 1 1 1 0 Amidohydrolase family Amidohydro_2 PF04909.14 EFC43024.1 - 0.03 14.1 0.0 0.61 9.8 0.0 2.7 2 1 0 2 2 2 0 Amidohydrolase Tubulin PF00091.25 EFC43025.1 - 3.7e-51 174.1 0.3 6.8e-51 173.3 0.1 1.5 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EFC43025.1 - 0.0012 18.2 0.0 0.0022 17.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin like M_domain PF12938.7 EFC43026.1 - 0.0054 16.6 1.1 0.0083 15.9 1.1 1.2 1 0 0 1 1 1 1 M domain of GW182 PEP_hydrolase PF09370.10 EFC43026.1 - 0.076 12.2 0.0 0.41 9.8 0.0 2.0 2 0 0 2 2 2 0 Phosphoenolpyruvate hydrolase-like ROK PF00480.20 EFC43027.1 - 2.3e-47 161.9 0.8 2.6e-47 161.7 0.8 1.0 1 0 0 1 1 1 1 ROK family Glucokinase PF02685.16 EFC43027.1 - 0.13 11.2 0.2 0.68 8.9 0.2 2.0 2 0 0 2 2 2 0 Glucokinase Preseq_ALAS PF09029.10 EFC43028.1 - 0.068 13.7 0.3 12 6.4 0.0 2.2 1 1 0 2 2 2 0 5-aminolevulinate synthase presequence GLTSCR1 PF15249.6 EFC43029.1 - 3.8e-18 65.8 0.8 3.8e-18 65.8 0.8 1.8 2 0 0 2 2 2 1 Conserved region of unknown function on GLTSCR protein DUF3987 PF13148.6 EFC43029.1 - 0.19 10.7 0.2 0.35 9.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) FSA_C PF10479.9 EFC43029.1 - 2.9 5.9 16.4 0.051 11.7 5.5 2.1 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus Guanylate_cyc PF00211.20 EFC43030.1 - 3e-21 75.9 0.0 1.1e-20 74.1 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain OpuAC PF04069.12 EFC43030.1 - 0.0077 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Substrate binding domain of ABC-type glycine betaine transport system OMP_b-brl_2 PF13568.6 EFC43030.1 - 0.063 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain Shisa PF13908.6 EFC43030.1 - 0.088 13.0 0.3 0.17 12.1 0.3 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Ras PF00071.22 EFC43032.1 - 3.1e-26 91.9 3.6 1.7e-21 76.5 1.5 3.6 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFC43032.1 - 1.2e-14 54.6 0.4 1e-07 32.2 0.1 2.7 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43032.1 - 3.1e-07 30.0 0.1 1.5e-05 24.5 0.0 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC43032.1 - 0.045 13.8 0.0 0.16 12.1 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sen15 PF09631.10 EFC43033.1 - 0.17 12.2 0.8 0.28 11.5 0.1 1.7 2 0 0 2 2 2 0 Sen15 protein adh_short PF00106.25 EFC43034.1 - 2.7e-18 66.1 0.0 3.3e-18 65.8 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43034.1 - 2.6e-17 63.2 0.0 3e-17 63.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43034.1 - 0.025 14.5 0.0 0.028 14.3 0.0 1.1 1 0 0 1 1 1 0 KR domain DUF2120 PF09893.9 EFC43034.1 - 0.025 14.7 0.1 0.037 14.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) QRPTase_C PF01729.19 EFC43034.1 - 0.092 12.5 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain MbtH PF03621.13 EFC43034.1 - 0.2 11.2 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 MbtH-like protein CAMSAP_CKK PF08683.11 EFC43035.1 - 7.2e-21 74.5 0.6 6.7e-20 71.4 0.6 2.5 1 1 0 1 1 1 1 Microtubule-binding calmodulin-regulated spectrin-associated Actin PF00022.19 EFC43036.1 - 2.8e-107 358.9 0.0 1.1e-106 356.9 0.0 1.7 1 1 0 1 1 1 1 Actin LRR_6 PF13516.6 EFC43037.1 - 7.2e-25 84.9 29.0 8.4e-06 25.4 0.4 9.6 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC43037.1 - 3.5e-06 27.3 24.0 0.064 13.7 0.0 6.8 6 1 1 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC43037.1 - 0.00025 21.1 20.8 7.7 7.5 0.0 8.8 8 3 0 8 8 8 2 Leucine Rich Repeat DUF268 PF03269.14 EFC43037.1 - 0.033 14.0 0.1 5.1 6.9 0.0 2.4 2 0 0 2 2 2 0 Caenorhabditis protein of unknown function, DUF268 LRR_8 PF13855.6 EFC43037.1 - 0.084 12.7 29.1 1.8 8.4 1.4 8.3 4 2 3 7 7 7 0 Leucine rich repeat Ribosomal_L24e PF01246.20 EFC43038.1 - 3.2e-29 100.9 0.3 6.5e-29 100.0 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e ABC_tran PF00005.27 EFC43039.1 - 3.7e-34 118.2 0.0 9.6e-34 116.8 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EFC43039.1 - 3.9e-08 33.0 0.2 6.2e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC43039.1 - 0.00034 21.0 0.1 0.00082 19.8 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 EFC43039.1 - 0.00036 20.4 0.0 0.00046 20.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC43039.1 - 0.00038 20.1 0.3 0.00085 19.0 0.3 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 EFC43039.1 - 0.0026 17.4 0.0 0.28 10.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 EFC43039.1 - 0.0036 17.7 0.6 0.79 10.1 0.1 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC43039.1 - 0.0037 17.5 0.7 0.053 13.8 0.7 2.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC43039.1 - 0.0044 16.9 0.0 0.0097 15.8 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase ABC_ATPase PF09818.9 EFC43039.1 - 0.0054 15.6 0.6 0.025 13.4 0.0 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_30 PF13604.6 EFC43039.1 - 0.017 14.9 0.0 0.26 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFC43039.1 - 0.022 14.7 0.0 0.18 11.7 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_21 PF13304.6 EFC43039.1 - 0.022 14.6 0.0 0.66 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EFC43039.1 - 0.028 14.4 0.2 0.25 11.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EFC43039.1 - 0.036 13.8 0.1 0.28 10.9 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein SbcCD_C PF13558.6 EFC43039.1 - 0.054 13.7 0.4 0.5 10.7 0.4 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 EFC43039.1 - 0.056 12.6 0.0 0.094 11.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_18 PF13238.6 EFC43039.1 - 0.073 13.6 1.7 0.13 12.8 0.2 2.3 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFC43039.1 - 0.1 13.1 0.1 0.19 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EFC43039.1 - 0.1 12.6 0.7 0.52 10.4 0.1 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain APS_kinase PF01583.20 EFC43039.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase F-box PF00646.33 EFC43040.1 - 0.0046 16.8 0.1 0.016 15.1 0.1 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC43040.1 - 0.011 15.6 0.0 0.048 13.6 0.0 2.0 2 0 0 2 2 2 0 F-box-like PIN_2 PF10130.9 EFC43041.1 - 0.017 15.3 0.0 0.53 10.5 0.0 2.0 1 1 0 2 2 2 0 PIN domain Myotub-related PF06602.14 EFC43042.1 - 6.1e-130 433.2 1.1 1.2e-129 432.2 1.1 1.5 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 EFC43042.1 - 1.4e-07 31.4 1.4 8.6e-07 28.8 0.0 2.8 3 0 0 3 3 3 1 GRAM domain Taxilin PF09728.9 EFC43042.1 - 0.02 14.1 11.5 0.031 13.5 11.5 1.3 1 0 0 1 1 1 0 Myosin-like coiled-coil protein Y_phosphatase3 PF13350.6 EFC43042.1 - 0.042 13.8 0.6 0.089 12.7 0.0 1.8 2 0 0 2 2 2 0 Tyrosine phosphatase family DSPc PF00782.20 EFC43042.1 - 0.053 13.3 0.1 0.053 13.3 0.1 2.1 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Scm3 PF10384.9 EFC43042.1 - 0.84 9.4 5.0 1.2 8.9 1.8 2.7 2 1 0 2 2 2 0 Centromere protein Scm3 Jnk-SapK_ap_N PF09744.9 EFC43042.1 - 0.89 9.8 11.2 1.9 8.7 11.2 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 GPS2_interact PF15784.5 EFC43042.1 - 0.94 10.0 4.4 2.8 8.4 4.4 1.8 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain NHL PF01436.21 EFC43044.1 - 3.5e-21 74.1 9.2 0.14 12.3 0.0 10.8 10 0 0 10 10 10 7 NHL repeat Pkinase PF00069.25 EFC43044.1 - 4e-18 65.7 0.0 9.4e-18 64.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43044.1 - 4.1e-17 62.3 0.0 8.5e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC43044.1 - 1.2e-10 41.5 68.4 0.00046 20.5 7.7 5.0 5 0 0 5 5 5 4 EGF-like domain Arylesterase PF01731.20 EFC43044.1 - 0.033 14.4 0.4 40 4.5 0.0 4.6 4 0 0 4 4 4 0 Arylesterase HSP70 PF00012.20 EFC43045.1 - 6.6e-248 823.8 8.5 7.5e-248 823.6 8.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC43045.1 - 2.6e-18 66.0 1.3 1.3e-17 63.6 0.1 2.3 2 1 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC43045.1 - 0.0097 15.2 0.1 0.1 11.9 0.1 2.2 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase DDR PF08841.10 EFC43045.1 - 0.02 13.9 0.0 0.84 8.6 0.0 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 EFC43045.1 - 0.03 13.8 0.0 5 6.5 0.0 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family DUF3410 PF11890.8 EFC43045.1 - 0.077 12.8 0.2 0.19 11.6 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3410) EF-hand_7 PF13499.6 EFC43045.1 - 0.15 12.5 0.7 0.65 10.5 0.5 2.3 2 0 0 2 2 2 0 EF-hand domain pair Laminin_II PF06009.12 EFC43045.1 - 0.25 11.4 4.8 1.1 9.2 0.0 3.0 2 1 1 3 3 3 0 Laminin Domain II FtsA PF14450.6 EFC43045.1 - 0.43 11.0 3.1 9.5 6.7 0.2 3.3 3 2 0 3 3 3 0 Cell division protein FtsA CLTH PF10607.9 EFC43047.1 - 6.2e-26 91.1 2.9 6.2e-26 91.1 2.9 2.2 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 EFC43047.1 - 6e-05 23.0 1.0 0.00012 22.0 1.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFC43047.1 - 0.0015 18.8 0.6 0.0033 17.7 0.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFC43047.1 - 0.0055 16.6 0.3 0.012 15.6 0.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain SUKH_6 PF14568.6 EFC43047.1 - 0.024 15.1 0.3 0.072 13.5 0.3 1.9 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall zf-C3HC4 PF00097.25 EFC43047.1 - 0.047 13.6 1.1 0.11 12.4 1.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ApoLp-III PF07464.11 EFC43047.1 - 0.32 11.1 8.2 0.19 11.8 5.3 2.0 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) zf-Nse PF11789.8 EFC43047.1 - 0.37 10.6 3.1 0.99 9.3 3.1 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RPA_C PF08784.11 EFC43048.1 - 1e-07 32.5 0.3 1.3e-07 32.2 0.3 1.1 1 0 0 1 1 1 1 Replication protein A C terminal M20_dimer PF07687.14 EFC43048.1 - 0.01 15.7 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase dimerisation domain Pox_I3 PF04661.12 EFC43048.1 - 0.012 14.8 0.2 0.027 13.6 0.1 1.5 1 1 1 2 2 2 0 Poxvirus I3 ssDNA-binding protein tRNA_anti-codon PF01336.25 EFC43049.1 - 2.6e-05 24.1 0.1 3.5e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain COesterase PF00135.28 EFC43050.1 - 2.9e-97 326.7 2.4 3.4e-97 326.5 2.4 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFC43050.1 - 4e-07 30.1 1.6 0.0007 19.5 0.0 2.9 3 0 0 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC43050.1 - 0.073 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family PHD_like PF12910.7 EFC43050.1 - 0.081 12.9 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system PTR2 PF00854.21 EFC43051.1 - 1.4e-97 327.1 7.4 1.4e-97 327.1 7.4 2.0 1 1 1 2 2 2 1 POT family MFS_1 PF07690.16 EFC43051.1 - 3.9e-18 65.5 15.5 3.9e-18 65.5 15.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily UPF0370 PF13980.6 EFC43051.1 - 0.098 12.7 0.3 56 3.9 0.0 3.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0370) Pkinase PF00069.25 EFC43052.1 - 9.9e-56 189.0 0.0 7.2e-55 186.2 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43052.1 - 7.6e-27 94.2 0.0 4.3e-20 72.1 0.0 2.6 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFC43052.1 - 2.3e-05 24.4 0.0 0.0043 17.0 0.1 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC43052.1 - 0.0023 17.3 0.0 0.0096 15.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFC43052.1 - 0.0089 15.4 0.1 0.022 14.1 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 EFC43052.1 - 0.015 14.4 0.1 0.033 13.2 0.1 1.5 1 0 0 1 1 1 0 Seadornavirus VP7 DUF1911 PF08929.10 EFC43052.1 - 0.088 13.6 0.7 0.3 11.9 0.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) zf_C2HC_14 PF18574.1 EFC43052.1 - 0.2 11.5 0.8 0.49 10.2 0.8 1.6 1 0 0 1 1 1 0 C2HC Zing finger domain DUF1910 PF08928.10 EFC43052.1 - 0.32 11.0 9.5 1.4 8.9 0.5 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1910) DUF5566 PF17721.1 EFC43053.1 - 0.065 13.5 0.8 0.12 12.6 0.3 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5566) DUF4293 PF14126.6 EFC43053.1 - 6.5 7.0 11.1 31 4.8 11.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) FHA PF00498.26 EFC43054.1 - 1.2e-15 57.6 1.0 2.5e-15 56.6 1.0 1.6 1 0 0 1 1 1 1 FHA domain zf-C3HC4_2 PF13923.6 EFC43054.1 - 2.4e-10 40.1 13.9 2.4e-10 40.1 13.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC43054.1 - 9.3e-10 38.7 13.6 2.3e-09 37.4 13.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFC43054.1 - 8.2e-09 35.2 10.9 1.6e-08 34.3 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC43054.1 - 1.3e-08 34.5 14.5 3.9e-08 33.0 14.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC43054.1 - 1.3e-07 31.6 11.2 2.5e-07 30.6 10.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 EFC43054.1 - 4.9e-07 29.8 12.9 1.4e-06 28.4 12.9 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFC43054.1 - 8.6e-07 28.7 11.1 1.8e-06 27.7 11.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 U-box PF04564.15 EFC43054.1 - 1e-06 28.8 0.0 2.3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-RING_10 PF16685.5 EFC43054.1 - 4.4e-06 26.7 10.5 1.2e-05 25.4 10.5 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 EFC43054.1 - 0.00025 21.3 16.9 0.00038 20.7 15.0 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain Yop-YscD_cpl PF16697.5 EFC43054.1 - 0.00045 20.5 0.0 0.00092 19.5 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 EFC43054.1 - 0.0013 18.6 18.2 0.0039 17.1 18.2 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 EFC43054.1 - 0.0041 16.9 10.5 0.009 15.8 10.0 1.9 1 1 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 EFC43054.1 - 0.23 11.5 8.5 0.21 11.6 6.8 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Methyltransf_11 PF08241.12 EFC43055.1 - 1.4e-14 54.5 0.0 9.9e-14 51.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC43055.1 - 3.3e-14 53.0 0.0 9e-14 51.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC43055.1 - 1.5e-12 48.1 0.0 1.3e-10 41.8 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC43055.1 - 3.2e-10 40.0 0.5 1.2e-08 34.9 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC43055.1 - 2.8e-08 34.4 1.3 3.9e-07 30.7 0.3 3.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFC43055.1 - 9.4e-06 25.6 0.0 1.9e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase Met_10 PF02475.16 EFC43055.1 - 7.3e-05 22.6 0.2 0.00045 20.0 0.0 2.2 2 0 0 2 2 2 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 EFC43055.1 - 8.8e-05 22.2 0.0 0.00024 20.8 0.0 1.7 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 EFC43055.1 - 0.00016 21.3 0.4 0.00091 18.8 0.2 2.4 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase Methyltransf_29 PF03141.16 EFC43055.1 - 0.00019 20.1 0.0 0.00036 19.2 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 EFC43055.1 - 0.0002 20.8 0.0 0.0005 19.5 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 EFC43055.1 - 0.0041 16.8 0.0 0.0088 15.7 0.0 1.5 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.14 EFC43055.1 - 0.0063 16.1 0.0 1.3 8.5 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 EFC43055.1 - 0.04 14.0 0.0 0.52 10.4 0.0 2.6 1 1 1 2 2 2 0 FtsJ-like methyltransferase Methyltransf_9 PF08003.11 EFC43055.1 - 0.079 11.9 0.0 0.17 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PEP_mutase PF13714.6 EFC43056.1 - 8.2e-54 182.6 0.5 9.6e-54 182.4 0.5 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 EFC43056.1 - 1.9e-16 59.7 0.2 2.8e-16 59.1 0.2 1.2 1 0 0 1 1 1 1 Isocitrate lyase family Asp_Glu_race PF01177.22 EFC43056.1 - 0.018 14.9 0.1 0.28 11.0 0.1 2.4 2 0 0 2 2 2 0 Asp/Glu/Hydantoin racemase S-methyl_trans PF02574.16 EFC43056.1 - 0.022 14.6 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 Homocysteine S-methyltransferase Bromo_TP PF07524.13 EFC43057.1 - 6.9e-07 29.2 0.0 1.5e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 EFC43057.1 - 0.0016 18.6 1.0 0.0068 16.6 0.0 2.7 2 0 0 2 2 2 1 Histone-fold protein RGS PF00615.19 EFC43058.1 - 5.6e-08 33.1 14.2 3.8e-07 30.4 9.8 3.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain Reticulon PF02453.17 EFC43058.1 - 0.028 14.4 4.7 1.2 9.1 0.2 2.8 3 0 0 3 3 3 0 Reticulon SP_C-Propep PF08999.10 EFC43058.1 - 0.14 12.0 1.5 12 5.7 0.3 2.4 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide F-box-like PF12937.7 EFC43060.1 - 3e-06 27.0 1.1 3.8e-06 26.7 0.1 1.7 2 0 0 2 2 2 1 F-box-like DUF5353 PF17304.2 EFC43060.1 - 0.077 12.7 4.7 3.4 7.5 0.5 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5353) F-box PF00646.33 EFC43060.1 - 0.078 12.9 1.1 0.21 11.5 1.1 1.7 1 1 0 1 1 1 0 F-box domain Zn_clus PF00172.18 EFC43061.1 - 3e-06 27.2 9.5 3e-06 27.2 9.5 2.8 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4381 PF14316.6 EFC43061.1 - 0.17 12.1 0.0 0.52 10.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Methyltransf_31 PF13847.6 EFC43063.1 - 0.0023 17.7 0.0 0.0052 16.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC43063.1 - 0.0059 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC43063.1 - 0.0098 16.6 0.0 0.026 15.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC43063.1 - 0.071 13.8 0.0 0.17 12.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain SNARE PF05739.19 EFC43063.1 - 2.4 8.2 4.2 5.5 7.1 4.2 1.6 1 0 0 1 1 1 0 SNARE domain DNA_primase_S PF01896.19 EFC43064.1 - 0.043 13.9 0.1 0.072 13.1 0.1 1.4 1 0 0 1 1 1 0 DNA primase small subunit F-box-like PF12937.7 EFC43066.1 - 0.00082 19.2 0.2 0.0017 18.2 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC43066.1 - 0.0026 17.6 0.3 0.0051 16.7 0.3 1.5 1 0 0 1 1 1 1 F-box domain DUF4240 PF14024.6 EFC43066.1 - 0.0072 16.5 1.5 0.09 13.0 1.5 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4240) T5orf172 PF10544.9 EFC43067.1 - 0.025 15.1 1.6 0.18 12.4 0.1 2.7 3 0 0 3 3 3 0 T5orf172 domain GIY-YIG PF01541.24 EFC43067.1 - 0.068 13.5 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 GIY-YIG catalytic domain DUF4709 PF15821.5 EFC43067.1 - 0.56 10.5 5.6 0.46 10.8 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4709) Shisa PF13908.6 EFC43068.1 - 0.082 13.1 1.5 0.14 12.4 1.5 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4709 PF15821.5 EFC43069.1 - 0.07 13.4 0.4 0.25 11.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) p450 PF00067.22 EFC43070.1 - 3.8e-71 240.2 0.3 4.4e-71 240.0 0.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 EFC43071.1 - 4.1e-10 39.0 0.0 4.8e-10 38.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LRR_6 PF13516.6 EFC43072.1 - 7.8e-28 94.1 10.5 5.3e-05 22.9 0.0 6.4 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC43072.1 - 1.4e-17 63.2 16.8 1.3e-10 40.8 0.7 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC43072.1 - 1.9e-17 63.1 12.7 3.9e-06 27.1 0.1 4.2 2 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC43072.1 - 2.4e-07 30.4 7.7 4.1 8.3 0.0 6.4 6 1 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC43072.1 - 0.036 13.6 3.6 0.033 13.7 0.8 2.1 1 1 2 3 3 3 0 Leucine-rich repeat LRR_5 PF13306.6 EFC43072.1 - 0.14 12.1 2.1 0.27 11.2 1.7 1.8 1 1 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) DUF4032 PF13224.6 EFC43072.1 - 0.16 11.9 0.2 9.4 6.1 0.0 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4032) ADH_N PF08240.12 EFC43073.1 - 7.9e-11 41.8 0.0 1.7e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFC43073.1 - 7.5e-10 40.0 0.0 0.0028 18.7 0.0 2.7 2 1 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC43073.1 - 6.4e-07 29.4 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFC43073.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase MFS_1 PF07690.16 EFC43074.1 - 7.4e-17 61.3 37.7 7.4e-17 61.3 37.7 2.7 1 1 2 3 3 3 1 Major Facilitator Superfamily MFS_3 PF05977.13 EFC43074.1 - 2.3e-15 56.0 3.8 2.3e-15 56.0 3.8 2.0 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 EFC43074.1 - 0.00022 20.2 26.8 0.00099 18.1 25.0 2.4 1 1 0 1 1 1 1 MFS_1 like family MFS_2 PF13347.6 EFC43074.1 - 0.00074 18.2 8.1 0.00074 18.2 8.1 3.2 2 2 1 3 3 3 1 MFS/sugar transport protein ABC2_membrane PF01061.24 EFC43075.1 - 5.6e-40 137.0 21.4 9e-40 136.3 21.4 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC43075.1 - 8.6e-20 71.7 0.4 1.9e-19 70.5 0.4 1.6 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFC43075.1 - 0.0026 17.5 0.2 0.0062 16.3 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFC43075.1 - 0.0041 16.6 1.0 2.8 7.3 0.2 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC43075.1 - 0.0099 15.8 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 EFC43075.1 - 0.013 15.4 0.6 0.033 14.0 0.1 1.9 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Nodulin PF02451.15 EFC43075.1 - 0.1 12.1 0.4 0.25 10.8 0.4 1.6 1 0 0 1 1 1 0 Nodulin F-box PF00646.33 EFC43076.1 - 0.00013 21.7 0.1 0.00073 19.4 0.1 2.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC43076.1 - 0.0021 17.9 0.8 0.0064 16.4 0.2 2.2 2 0 0 2 2 2 1 F-box-like RCC1_2 PF13540.6 EFC43077.1 - 0.009 15.8 0.2 0.009 15.8 0.2 3.3 3 1 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC43078.1 - 3.5e-35 121.7 1.4 7e-35 120.7 1.4 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43078.1 - 1.1e-18 67.5 0.1 2.6e-18 66.3 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase SL4P PF17618.2 EFC43078.1 - 0.019 15.0 0.2 0.065 13.3 0.2 1.9 1 0 0 1 1 1 0 Uncharacterized Strongylid L4 protein APH PF01636.23 EFC43078.1 - 0.049 13.5 0.2 0.096 12.6 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Myc-LZ PF02344.15 EFC43078.1 - 0.067 13.3 0.9 0.15 12.2 0.9 1.6 1 0 0 1 1 1 0 Myc leucine zipper domain ERp29 PF07749.12 EFC43079.1 - 0.25 12.3 7.9 23 6.0 0.0 3.8 3 1 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF737 PF05300.11 EFC43079.1 - 4.4 7.6 21.5 0.22 11.9 9.5 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF737) Peripla_BP_6 PF13458.6 EFC43080.1 - 0.021 14.5 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Peptidase_S8 PF00082.22 EFC43081.1 - 1.2e-22 80.5 1.5 9e-22 77.7 0.1 2.1 2 0 0 2 2 2 2 Subtilase family GFO_IDH_MocA PF01408.22 EFC43082.1 - 2.5e-21 76.7 0.0 4.1e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EFC43082.1 - 0.044 14.4 0.0 0.07 13.8 0.0 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain MRG PF05712.13 EFC43083.1 - 0.0098 15.2 0.3 0.017 14.4 0.3 1.4 1 0 0 1 1 1 1 MRG DUF2263 PF10021.9 EFC43083.1 - 0.071 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2263) MAPEG PF01124.18 EFC43084.1 - 2.2e-13 50.2 1.1 3.3e-13 49.7 1.1 1.3 1 0 0 1 1 1 1 MAPEG family Voltage_CLC PF00654.20 EFC43086.1 - 3.3e-58 197.6 28.5 3.3e-58 197.6 28.5 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel Nmad2 PF18753.1 EFC43086.1 - 0.025 14.0 0.3 0.046 13.2 0.3 1.3 1 0 0 1 1 1 0 Nucleotide modification associated domain 2 ANAPC4_WD40 PF12894.7 EFC43088.1 - 1.2e-19 70.4 9.4 3.2e-09 36.9 0.4 5.0 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC43088.1 - 9.9e-19 67.4 11.7 0.00027 21.7 0.1 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat eIF2A PF08662.11 EFC43088.1 - 7.6e-08 32.5 1.7 2.1e-05 24.5 0.2 3.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 EFC43088.1 - 0.00011 21.5 1.7 0.44 9.5 0.1 3.1 1 1 2 3 3 3 3 Coatomer WD associated region Ge1_WD40 PF16529.5 EFC43088.1 - 0.0046 16.0 0.0 1.5 7.7 0.0 2.8 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 EFC43088.1 - 0.011 14.1 0.0 0.046 12.0 0.0 1.8 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EFC43088.1 - 0.04 13.3 0.9 0.27 10.5 0.9 2.3 1 1 0 1 1 1 0 WD40-like domain IKI3 PF04762.12 EFC43088.1 - 0.046 11.7 5.5 0.53 8.2 0.1 3.0 2 1 1 3 3 3 0 IKI3 family HECT PF00632.25 EFC43089.1 - 2.7e-90 303.0 0.0 3.3e-90 302.7 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Guanylate_cyc PF00211.20 EFC43090.1 - 0.00034 20.3 0.1 0.001 18.8 0.1 1.8 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF5046 PF16465.5 EFC43090.1 - 0.011 15.3 0.7 0.094 12.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) TPR_2 PF07719.17 EFC43090.1 - 0.014 15.4 0.1 0.038 14.1 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Carbam_trans_C PF16861.5 EFC43090.1 - 0.092 12.3 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus TPR_8 PF13181.6 EFC43090.1 - 0.11 12.8 0.1 0.37 11.1 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat VWA PF00092.28 EFC43090.1 - 0.11 12.7 4.4 2.6 8.3 0.4 2.6 2 0 0 2 2 2 0 von Willebrand factor type A domain TPR_1 PF00515.28 EFC43090.1 - 0.12 12.3 0.3 0.29 11.0 0.3 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat LRR_6 PF13516.6 EFC43091.1 - 1.2e-40 134.1 0.6 0.00011 22.0 0.0 8.7 8 0 0 8 8 8 7 Leucine Rich repeat Pkinase PF00069.25 EFC43091.1 - 7.6e-31 107.4 0.4 7.6e-31 107.4 0.4 2.2 2 0 0 2 2 2 1 Protein kinase domain DUF4116 PF13475.6 EFC43091.1 - 6.8e-27 93.0 32.8 2.1e-10 40.2 0.2 5.6 5 1 0 5 5 5 4 Domain of unknown function (DUF4116) LRR_8 PF13855.6 EFC43091.1 - 5e-21 74.2 1.5 7.6e-08 32.0 0.0 4.1 1 1 0 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC43091.1 - 7.9e-18 64.3 9.9 0.00042 20.6 0.0 6.4 2 1 1 5 5 5 4 Leucine Rich repeats (2 copies) Pkinase_Tyr PF07714.17 EFC43091.1 - 7.8e-17 61.4 0.3 3.5e-16 59.3 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase LRR_1 PF00560.33 EFC43091.1 - 3.1e-10 39.1 0.0 41 5.3 0.0 8.7 8 0 0 8 8 8 0 Leucine Rich Repeat Pkinase_fungal PF17667.1 EFC43091.1 - 0.0004 19.3 0.1 0.0011 17.8 0.1 1.7 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC43091.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family CSTF2_hinge PF14327.6 EFC43091.1 - 0.46 11.0 2.5 3.3 8.2 0.1 3.8 3 0 0 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 Ras PF00071.22 EFC43092.1 - 8.5e-22 77.5 0.3 1.4e-21 76.8 0.3 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43092.1 - 9.1e-12 45.3 0.0 1.8e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43092.1 - 1.7e-06 27.6 2.9 1.5e-05 24.5 1.8 2.4 1 1 1 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC43092.1 - 0.0078 15.6 1.9 0.018 14.4 1.9 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 EFC43092.1 - 0.032 14.3 0.1 0.032 14.3 0.1 2.2 2 1 0 2 2 2 0 AAA domain DUF573 PF04504.14 EFC43093.1 - 0.087 13.5 1.9 0.16 12.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF573 Secretin_N_2 PF07655.13 EFC43094.1 - 0.015 15.8 18.6 0.28 11.7 7.9 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain POX PF07526.11 EFC43094.1 - 1.8 9.1 8.7 0.84 10.2 3.0 2.6 3 0 0 3 3 3 0 Associated with HOX adh_short PF00106.25 EFC43095.1 - 8.6e-43 146.1 0.5 1e-42 145.8 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43095.1 - 7.8e-41 140.2 0.0 9.7e-41 139.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43095.1 - 6.6e-13 49.0 1.9 2.9e-12 46.9 1.9 2.0 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EFC43095.1 - 9.8e-09 34.6 2.3 1.8e-07 30.4 2.3 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC43095.1 - 0.0002 20.9 1.6 0.0025 17.3 1.6 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC43095.1 - 0.0066 15.9 1.4 0.099 12.0 1.4 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFC43095.1 - 0.02 14.1 0.2 0.046 12.9 0.1 1.6 2 0 0 2 2 2 0 Male sterility protein Fe-S_biosyn PF01521.20 EFC43096.1 - 6.3e-13 48.9 0.0 7e-13 48.7 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF2195 PF09961.9 EFC43096.1 - 0.054 13.4 0.0 0.074 13.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2195) GAT PF03127.14 EFC43097.1 - 2.4e-15 56.6 1.2 6e-15 55.3 1.2 1.7 1 0 0 1 1 1 1 GAT domain VHS PF00790.19 EFC43097.1 - 4.7e-14 52.4 0.2 8.4e-14 51.6 0.2 1.4 1 0 0 1 1 1 1 VHS domain UNC45-central PF11701.8 EFC43097.1 - 0.0073 16.3 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Myosin-binding striated muscle assembly central Dopey_N PF04118.14 EFC43097.1 - 0.057 12.5 0.2 0.084 12.0 0.2 1.2 1 0 0 1 1 1 0 Dopey, N-terminal DENN PF02141.21 EFC43097.1 - 0.1 12.6 1.4 0.25 11.3 1.4 1.6 1 0 0 1 1 1 0 DENN (AEX-3) domain Ras PF00071.22 EFC43098.1 - 3.2e-51 173.1 0.0 3.7e-51 172.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43098.1 - 1.1e-19 70.9 0.0 2e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43098.1 - 3.2e-13 49.5 0.1 3.8e-13 49.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC43098.1 - 5.4e-06 26.1 0.0 2.3e-05 24.0 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC43098.1 - 8.2e-06 25.9 0.0 1.6e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC43098.1 - 8.3e-05 22.6 0.0 0.0052 16.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EFC43098.1 - 0.0063 16.5 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain Gtr1_RagA PF04670.12 EFC43098.1 - 0.015 14.7 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region NHL PF01436.21 EFC43099.1 - 0.0049 16.8 0.1 0.061 13.4 0.0 2.6 3 0 0 3 3 3 1 NHL repeat MCM PF00493.23 EFC43100.1 - 2.3e-62 210.0 0.0 5.6e-62 208.8 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EFC43100.1 - 9.8e-27 93.3 1.0 2.1e-26 92.2 1.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFC43100.1 - 6.1e-16 58.6 2.2 1.6e-15 57.3 2.2 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 EFC43100.1 - 2.2e-08 34.2 0.0 5.1e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFC43100.1 - 5.5e-08 32.4 0.0 0.00059 19.3 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA PF00004.29 EFC43100.1 - 0.0053 17.2 0.1 0.032 14.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC43100.1 - 0.011 15.4 0.0 0.16 11.6 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain cobW PF02492.19 EFC43100.1 - 0.014 15.0 0.1 0.028 14.0 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MCM_N PF14551.6 EFC43100.1 - 0.015 15.9 0.1 0.052 14.1 0.1 1.9 1 0 0 1 1 1 0 MCM N-terminal domain ADK_lid PF05191.14 EFC43100.1 - 0.029 14.4 0.7 0.065 13.2 0.7 1.7 1 0 0 1 1 1 0 Adenylate kinase, active site lid FtsK_SpoIIIE PF01580.18 EFC43100.1 - 0.04 13.3 0.1 0.04 13.3 0.1 1.7 2 0 0 2 2 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EFC43100.1 - 0.075 13.3 0.3 0.3 11.4 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC43100.1 - 0.076 13.4 0.6 0.38 11.1 0.6 2.3 1 1 0 1 1 1 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 EFC43100.1 - 0.082 11.8 0.1 0.14 11.1 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 EFC43100.1 - 0.12 12.9 0.0 0.34 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC43100.1 - 0.12 11.8 0.1 0.31 10.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Zn-ribbon_8 PF09723.10 EFC43100.1 - 0.19 11.9 1.1 0.58 10.3 1.1 1.8 1 0 0 1 1 1 0 Zinc ribbon domain Symplekin_C PF12295.8 EFC43101.1 - 9.9e-27 94.2 3.8 9.9e-27 94.2 3.8 3.3 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 EFC43101.1 - 5.6e-19 68.7 1.6 5.6e-19 68.7 1.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) GCIP PF13324.6 EFC43102.1 - 0.0098 15.5 0.5 0.0098 15.5 0.5 1.7 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting DNA_pol3_beta_3 PF02768.15 EFC43102.1 - 0.13 12.1 2.0 1.4 8.7 0.2 2.3 2 0 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain Amino_oxidase PF01593.24 EFC43103.1 - 2.2e-81 274.5 0.0 1.8e-78 264.9 0.0 3.4 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase GDI PF00996.18 EFC43103.1 - 2.7e-38 131.6 7.2 8.1e-36 123.5 0.2 2.9 2 1 0 2 2 2 2 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EFC43103.1 - 5.6e-16 58.5 0.1 2.8e-09 37.1 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain SWIRM PF04433.17 EFC43103.1 - 4.8e-07 30.0 1.1 4.8e-07 30.0 1.1 4.1 5 0 0 5 5 5 1 SWIRM domain Pyr_redox_2 PF07992.14 EFC43103.1 - 8e-07 28.6 0.0 3e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC43103.1 - 2.9e-06 27.7 0.7 8e-05 23.1 0.1 3.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC43103.1 - 4.4e-06 25.7 0.1 0.00017 20.4 0.0 3.3 4 0 0 4 4 4 1 HI0933-like protein FAD_oxidored PF12831.7 EFC43103.1 - 9.5e-05 21.9 0.0 0.0009 18.7 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase Arm PF00514.23 EFC43103.1 - 0.00014 21.8 2.9 26 5.0 0.0 6.2 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat DAO PF01266.24 EFC43103.1 - 0.0002 21.1 0.1 0.00081 19.1 0.2 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EFC43103.1 - 0.024 13.7 0.0 0.078 12.0 0.0 1.9 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 EFC43103.1 - 0.06 12.6 0.1 0.5 9.5 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain CLCA PF08434.11 EFC43103.1 - 0.069 12.5 0.7 0.58 9.4 0.3 2.3 2 0 0 2 2 2 0 Calcium-activated chloride channel N terminal Thi4 PF01946.17 EFC43103.1 - 0.087 12.1 0.0 0.22 10.8 0.0 1.6 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 EFC43103.1 - 0.12 11.4 0.1 0.28 10.2 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 EFC43103.1 - 0.18 11.1 0.0 0.45 9.8 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF3959 PF13105.6 EFC43104.1 - 2 7.9 5.8 3.7 7.0 5.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Acyltransferase PF01553.21 EFC43105.1 - 2.5e-25 88.7 0.0 3.3e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase UCH PF00443.29 EFC43106.1 - 1.3e-44 152.6 2.7 1.6e-44 152.3 2.7 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC43106.1 - 7.8e-17 61.8 11.0 2.8e-16 60.0 11.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFC43106.1 - 1e-06 28.4 0.0 2.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.6 EFC43106.1 - 0.16 11.4 0.1 0.16 11.4 0.1 3.1 2 2 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF1682 PF07946.14 EFC43106.1 - 3 6.9 13.0 2.8 7.1 11.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1682) Arm PF00514.23 EFC43107.1 - 1.7e-15 56.4 1.6 0.00028 20.8 0.1 4.8 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC43107.1 - 0.0094 16.4 0.0 0.14 12.7 0.0 2.5 2 0 0 2 2 2 1 HEAT-like repeat DUF577 PF04510.12 EFC43107.1 - 0.016 15.1 0.8 6.1 6.7 0.1 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF577) fn2 PF00040.19 EFC43107.1 - 0.55 10.6 2.6 4.4 7.7 0.1 3.0 3 0 0 3 3 3 0 Fibronectin type II domain Pkinase PF00069.25 EFC43108.1 - 1.4e-64 218.0 0.0 2.1e-64 217.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43108.1 - 2.9e-45 154.6 0.0 4.8e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43108.1 - 6.8e-07 28.9 0.0 2.1e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC43108.1 - 8.6e-05 21.5 0.0 0.0002 20.2 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC43108.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF5300 PF17224.3 EFC43108.1 - 0.027 14.7 0.1 0.073 13.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) U-box PF04564.15 EFC43108.1 - 0.073 13.3 0.1 0.27 11.4 0.1 2.0 1 0 0 1 1 1 0 U-box domain Mito_carr PF00153.27 EFC43109.1 - 4.8e-65 215.5 0.0 4.4e-23 81.0 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein ParE_toxin PF05016.15 EFC43109.1 - 0.077 13.6 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 ParE toxin of type II toxin-antitoxin system, parDE EMC3_TMCO1 PF01956.16 EFC43110.1 - 1.5e-41 142.0 2.4 1.9e-41 141.6 2.4 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Hanta_G1 PF01567.16 EFC43110.1 - 0.2 10.3 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 Hantavirus glycoprotein G1 MBOAT PF03062.19 EFC43111.1 - 7.4e-24 84.7 28.9 1.9e-23 83.4 28.2 1.9 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family SHIPPO-rpt PF07004.12 EFC43112.1 - 0.0023 18.8 34.2 0.066 14.2 2.7 6.8 6 1 0 6 6 6 4 Sperm-tail PG-rich repeat Glyco_transf_18 PF15024.6 EFC43113.1 - 2e-06 26.7 16.1 2e-06 26.7 16.1 1.8 1 1 0 2 2 2 1 Glycosyltransferase family 18 Ferric_reduct PF01794.19 EFC43114.1 - 0.083 13.0 13.1 2 8.6 11.3 2.5 1 1 1 2 2 2 0 Ferric reductase like transmembrane component Sel1 PF08238.12 EFC43115.1 - 1.3e-48 162.3 33.8 8.1e-08 32.7 0.3 11.3 11 1 0 11 11 11 9 Sel1 repeat TPR_11 PF13414.6 EFC43115.1 - 0.0014 18.3 11.6 3.1 7.6 0.4 4.9 4 1 0 4 4 4 3 TPR repeat TPR_16 PF13432.6 EFC43115.1 - 0.0039 17.8 5.4 28 5.5 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC43115.1 - 0.031 14.7 6.7 6.4 7.4 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC43115.1 - 3.6 7.6 20.2 6.2 6.8 0.1 7.2 8 0 0 8 8 8 0 Tetratricopeptide repeat AAA_6 PF12774.7 EFC43116.1 - 2.2e-151 503.4 0.0 5.5e-151 502.1 0.0 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EFC43116.1 - 3.8e-121 405.5 18.9 3.8e-121 405.5 18.9 4.8 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EFC43116.1 - 7.4e-110 367.8 17.4 7.4e-110 367.8 17.4 6.2 5 2 1 6 6 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFC43116.1 - 1.4e-104 349.1 0.3 1.4e-104 349.1 0.3 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFC43116.1 - 2.1e-80 269.0 0.7 2.1e-80 269.0 0.7 5.7 5 0 0 5 5 4 1 ATP-binding dynein motor region Dynein_C PF18199.1 EFC43116.1 - 2.3e-80 270.1 0.2 2.3e-80 270.1 0.2 3.1 4 0 0 4 4 3 1 Dynein heavy chain C-terminal domain AAA_7 PF12775.7 EFC43116.1 - 1.1e-67 227.1 5.7 1.3e-63 213.8 1.0 3.9 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC43116.1 - 9.8e-51 171.8 0.1 9.8e-51 171.8 0.1 2.9 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain MT PF12777.7 EFC43116.1 - 2.7e-45 154.9 15.2 5.2e-45 154.0 15.2 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EFC43116.1 - 7.4e-43 145.4 0.0 2e-40 137.6 0.0 4.0 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EFC43116.1 - 1.6e-23 83.2 1.8 1.3e-22 80.2 0.6 3.3 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFC43116.1 - 6.8e-20 71.5 0.4 0.00027 20.9 0.0 6.3 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFC43116.1 - 1.7e-13 50.6 1.8 3.2e-13 49.7 0.1 2.6 2 0 0 2 2 1 1 AAA+ lid domain AAA PF00004.29 EFC43116.1 - 4.2e-07 30.4 1.6 0.87 10.0 0.0 6.0 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC43116.1 - 1e-05 25.8 0.1 2.4 8.4 0.0 5.7 5 0 0 5 5 4 1 AAA domain AAA_16 PF13191.6 EFC43116.1 - 1.7e-05 25.3 8.4 2.5 8.5 0.2 7.0 6 1 1 7 7 7 1 AAA ATPase domain RNA_helicase PF00910.22 EFC43116.1 - 2.1e-05 24.8 0.3 3.2 8.2 0.0 4.4 4 0 0 4 4 3 2 RNA helicase T2SSE PF00437.20 EFC43116.1 - 0.041 12.9 0.2 2.3 7.2 0.0 3.3 3 0 0 3 3 3 0 Type II/IV secretion system protein Roc PF08477.13 EFC43116.1 - 0.059 13.6 0.3 9.5 6.5 0.1 3.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 EFC43116.1 - 0.21 12.2 8.1 0.37 11.3 0.0 5.2 6 1 1 7 7 4 0 AAA domain ABC_tran PF00005.27 EFC43116.1 - 0.22 12.0 3.7 8.6 6.9 0.0 4.5 4 0 0 4 4 3 0 ABC transporter FtsK_SpoIIIE PF01580.18 EFC43116.1 - 6.5 6.0 5.8 2.5 7.4 0.0 3.1 4 0 0 4 4 3 0 FtsK/SpoIIIE family AAA_22 PF13401.6 EFC43117.1 - 0.0055 17.0 0.2 0.13 12.6 0.2 2.8 2 1 0 2 2 2 1 AAA domain Mnd1 PF03962.15 EFC43117.1 - 0.034 14.4 0.4 0.034 14.4 0.4 3.0 3 0 0 3 3 3 0 Mnd1 HTH domain NACHT PF05729.12 EFC43117.1 - 0.046 13.6 0.3 0.24 11.3 0.3 2.1 1 1 0 1 1 1 0 NACHT domain DS PF01916.17 EFC43118.1 - 2e-126 421.1 0.0 2.4e-126 420.8 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase adh_short_C2 PF13561.6 EFC43119.1 - 2.1e-44 151.8 0.0 5.3e-44 150.5 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC43119.1 - 2.5e-36 125.0 0.0 3.5e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC43119.1 - 3.2e-05 23.9 0.0 0.00017 21.6 0.0 1.8 2 0 0 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 EFC43119.1 - 0.088 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF2207 PF09972.9 EFC43120.1 - 9.5e-06 24.6 0.1 1.3e-05 24.2 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Erf4 PF10256.9 EFC43120.1 - 0.0043 17.1 0.3 0.034 14.2 0.1 2.1 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family 7TM-7TMR_HD PF07698.11 EFC43120.1 - 0.01 15.6 1.4 0.016 15.0 1.4 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase RRM_9 PF18444.1 EFC43121.1 - 0.082 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif DUF641 PF04859.12 EFC43121.1 - 0.1 12.9 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) COX15-CtaA PF02628.15 EFC43123.1 - 3.8e-101 338.4 5.6 4.5e-101 338.2 5.6 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF4079 PF13301.6 EFC43123.1 - 0.095 12.9 2.0 0.17 12.0 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) Acetyltransf_1 PF00583.25 EFC43124.1 - 2.6e-09 37.3 0.0 3.2e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC43124.1 - 8.7e-09 35.4 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC43124.1 - 1.3e-05 25.5 0.1 2.3e-05 24.7 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC43124.1 - 8.6e-05 22.4 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein RRM_5 PF13893.6 EFC43125.1 - 1.7e-13 50.2 0.0 4.5e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EFC43125.1 - 9.6e-11 41.4 2.8 0.00014 21.6 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) tRNA-Thr_ED PF08915.11 EFC43126.1 - 0.023 14.7 0.0 0.7 9.9 0.0 2.7 2 0 0 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase SPATIAL PF15256.6 EFC43126.1 - 1.8 8.8 8.9 0.13 12.5 2.3 2.3 2 1 0 2 2 2 0 SPATIAL Aldo_ket_red PF00248.21 EFC43127.1 - 1.4e-65 221.4 0.0 1.7e-65 221.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family WH1 PF00568.23 EFC43128.1 - 6.3e-16 58.3 0.2 9.6e-16 57.7 0.2 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 EFC43128.1 - 4.5e-13 49.3 0.1 1.2e-12 48.0 0.1 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Drf_FH1 PF06346.12 EFC43128.1 - 0.0073 16.0 31.0 0.0073 16.0 31.0 2.4 3 0 0 3 3 3 1 Formin Homology Region 1 Pirin PF02678.16 EFC43129.1 - 1.4e-27 95.7 0.0 2.9e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.11 EFC43129.1 - 8.8e-06 25.4 0.0 3.9e-05 23.3 0.0 1.9 2 0 0 2 2 2 1 Cupin domain Pirin_C_2 PF17954.1 EFC43129.1 - 2.6e-05 24.3 0.1 0.0013 18.9 0.0 2.6 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain TerD PF02342.18 EFC43130.1 - 2e-11 43.7 0.0 3.3e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 TerD domain ubiquitin PF00240.23 EFC43130.1 - 7.6e-07 28.8 0.2 2.6e-06 27.1 0.2 2.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC43130.1 - 0.0094 15.8 0.2 0.023 14.5 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF4177 PF13783.6 EFC43130.1 - 0.14 12.5 0.0 0.48 10.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) ThiF PF00899.21 EFC43131.1 - 6.2e-70 235.3 0.1 6.6e-42 143.5 0.0 2.3 2 0 0 2 2 2 2 ThiF family UCH PF00443.29 EFC43131.1 - 4.7e-11 42.7 1.7 0.00024 20.7 0.1 2.7 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase NAD_binding_7 PF13241.6 EFC43131.1 - 1.4e-07 31.9 0.3 0.00021 21.7 0.0 3.3 2 1 0 2 2 2 2 Putative NAD(P)-binding UBA_e1_thiolCys PF10585.9 EFC43131.1 - 3.5e-05 23.9 0.1 3.5e-05 23.9 0.1 3.4 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site Shikimate_DH PF01488.20 EFC43131.1 - 0.0023 18.0 2.6 1.8 8.6 0.1 3.0 3 0 0 3 3 3 2 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFC43131.1 - 0.021 14.2 0.0 5.3 6.4 0.0 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 EFC43131.1 - 0.033 14.4 0.3 18 5.7 0.0 3.3 3 0 0 3 3 3 0 TrkA-N domain Pyr_redox PF00070.27 EFC43131.1 - 0.23 12.0 0.5 3.4 8.3 0.1 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Actin PF00022.19 EFC43132.1 - 3.5e-10 39.1 0.0 6.3e-10 38.2 0.0 1.3 1 0 0 1 1 1 1 Actin zf-A20 PF01754.16 EFC43132.1 - 2.2e-06 27.5 6.2 4.6e-06 26.5 6.2 1.6 1 0 0 1 1 1 1 A20-like zinc finger MCD PF05292.11 EFC43132.1 - 0.059 12.9 0.1 0.1 12.1 0.1 1.3 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain DFRP_C PF16543.5 EFC43132.1 - 0.085 13.3 6.1 0.075 13.5 2.8 2.2 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 HMG_box PF00505.19 EFC43132.1 - 5.3 7.5 7.3 6 7.4 2.2 2.9 3 0 0 3 3 3 0 HMG (high mobility group) box zf-C2H2 PF00096.26 EFC43134.1 - 1.6e-10 40.8 6.5 0.00025 21.3 0.1 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 EFC43134.1 - 5.1e-07 29.8 7.2 0.0015 18.8 0.1 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 EFC43134.1 - 1.8e-05 25.2 4.9 0.042 14.7 1.8 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger Arf PF00025.21 EFC43134.1 - 7.4e-05 22.3 0.0 7.4e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family BTB PF00651.31 EFC43134.1 - 0.0068 16.6 0.0 0.023 14.9 0.0 2.0 1 0 0 1 1 1 1 BTB/POZ domain zf-C2H2_6 PF13912.6 EFC43134.1 - 0.27 11.3 4.6 4.4 7.4 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Ras PF00071.22 EFC43135.1 - 4.8e-51 172.6 1.0 9.7e-51 171.6 0.2 2.0 2 0 0 2 2 2 1 Ras family Pkinase PF00069.25 EFC43135.1 - 1.4e-28 100.0 4.8 1.4e-28 100.0 4.8 1.9 2 0 0 2 2 2 1 Protein kinase domain DUF4116 PF13475.6 EFC43135.1 - 1.9e-27 94.8 14.0 1.1e-11 44.3 0.0 5.8 7 0 0 7 7 7 3 Domain of unknown function (DUF4116) Roc PF08477.13 EFC43135.1 - 5.3e-26 91.2 0.0 2e-25 89.4 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Pkinase_Tyr PF07714.17 EFC43135.1 - 1.4e-12 47.5 1.3 2.9e-12 46.4 0.8 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Arf PF00025.21 EFC43135.1 - 4.2e-08 32.8 0.0 9.4e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Kdo PF06293.14 EFC43135.1 - 0.039 13.3 0.0 0.091 12.1 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FBA_2 PF07735.17 EFC43136.1 - 0.054 13.6 0.7 2.2 8.5 0.1 2.7 2 0 0 2 2 2 0 F-box associated Ras PF00071.22 EFC43136.1 - 0.083 12.5 0.2 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 Ras family p53-inducible11 PF14936.6 EFC43137.1 - 0.13 12.3 4.0 0.16 12.0 4.0 1.1 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 Rtt106_N PF18215.1 EFC43138.1 - 0.032 14.0 0.0 0.11 12.2 0.0 1.9 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain DUF2004 PF09406.10 EFC43138.1 - 0.15 12.4 0.1 0.73 10.2 0.0 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2004) Antimicrobial20 PF08256.11 EFC43138.1 - 0.24 12.0 0.5 1 10.1 0.5 2.1 1 0 0 1 1 1 0 Aurein-like antibiotic peptide Synaptobrevin PF00957.21 EFC43139.1 - 0.033 14.0 1.0 0.07 12.9 1.0 1.5 1 0 0 1 1 1 0 Synaptobrevin Rtt106_N PF18215.1 EFC43140.1 - 0.0033 17.1 0.0 0.021 14.6 0.0 2.2 2 0 0 2 2 2 1 Histone chaperone Rtt106 N-terminal domain DUF1700 PF08006.11 EFC43140.1 - 0.1 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Pkinase PF00069.25 EFC43141.1 - 3.6e-42 144.6 0.2 5.5e-42 144.0 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43141.1 - 7.5e-27 94.2 0.1 1.1e-26 93.6 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC43141.1 - 2.5e-26 91.7 242.5 3.3e-05 24.2 10.0 16.7 15 1 1 16 16 16 11 EGF-like domain NHL PF01436.21 EFC43141.1 - 3.8e-13 48.7 3.3 0.00033 20.5 0.0 8.4 9 0 0 9 9 9 2 NHL repeat EGF PF00008.27 EFC43141.1 - 1.6e-09 37.9 154.0 0.00024 21.3 3.9 13.9 13 0 0 13 13 13 8 EGF-like domain EGF_Tenascin PF18720.1 EFC43141.1 - 0.00059 19.8 7.6 0.00059 19.8 7.6 12.5 12 1 0 12 12 11 3 Tenascin EGF domain Kdo PF06293.14 EFC43141.1 - 0.028 13.8 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC43141.1 - 0.11 11.2 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF4834 PF16118.5 EFC43141.1 - 0.23 12.4 3.6 0.19 12.7 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Bowman-Birk_leg PF00228.20 EFC43141.1 - 0.54 10.7 6.8 34 5.0 1.2 4.8 3 0 0 3 3 3 0 Bowman-Birk serine protease inhibitor family hEGF PF12661.7 EFC43141.1 - 0.57 10.9 175.1 0.046 14.4 5.6 16.8 17 0 0 17 17 16 0 Human growth factor-like EGF SurE PF01975.17 EFC43142.1 - 0.087 12.6 0.1 0.11 12.2 0.1 1.1 1 0 0 1 1 1 0 Survival protein SurE Vfa1 PF08432.10 EFC43143.1 - 0.35 11.2 12.6 0.75 10.1 12.6 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3611 PF12263.8 EFC43144.1 - 0.038 13.9 0.1 0.042 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) ADP_ribosyl_GH PF03747.14 EFC43145.1 - 4.1e-11 43.1 0.0 6.1e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase CRISPR_Cas2 PF09827.9 EFC43145.1 - 0.019 15.2 0.3 0.22 11.7 0.1 2.5 2 0 0 2 2 2 0 CRISPR associated protein Cas2 DUF4367 PF14285.6 EFC43145.1 - 0.031 14.7 0.3 0.063 13.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Fanconi_A_N PF15865.5 EFC43145.1 - 0.053 12.9 0.3 0.33 10.3 0.1 2.0 2 0 0 2 2 2 0 Fanconi anaemia group A protein N terminus TnsE_C PF18623.1 EFC43145.1 - 0.067 13.1 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 TnsE C-terminal domain DUF1479 PF07350.12 EFC43146.1 - 3.3e-12 45.9 0.3 1.8e-05 23.7 0.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 EFC43146.1 - 5.5e-06 26.8 0.2 0.26 11.5 0.1 3.2 2 1 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Macoilin PF09726.9 EFC43146.1 - 0.8 8.2 13.8 1.3 7.5 13.8 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 EFC43146.1 - 2.6 6.7 6.6 3.8 6.2 6.6 1.2 1 0 0 1 1 1 0 Presenilin DUF5023 PF16426.5 EFC43147.1 - 0.19 11.3 0.7 0.39 10.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5023) C_Hendra PF16821.5 EFC43147.1 - 0.29 11.0 6.9 0.11 12.3 4.1 1.8 2 0 0 2 2 2 0 C protein from hendra and measles viruses Presenilin PF01080.17 EFC43147.1 - 1.8 7.2 6.2 2.6 6.7 6.2 1.2 1 0 0 1 1 1 0 Presenilin SpuA_C PF18033.1 EFC43148.1 - 0.03 14.4 0.1 0.068 13.2 0.1 1.5 1 0 0 1 1 1 0 SpuA C-terminal TGBp3 PF02495.17 EFC43148.1 - 0.035 13.8 3.8 0.28 10.9 3.8 2.1 1 1 0 1 1 1 0 Triple gene block 3 DUF3430 PF11912.8 EFC43148.1 - 0.36 10.8 6.8 0.81 9.7 6.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3430) EF-hand_7 PF13499.6 EFC43149.1 - 1.2e-22 80.1 2.7 1e-12 48.3 0.5 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC43149.1 - 9.6e-19 65.5 11.3 9.3e-06 24.8 0.5 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC43149.1 - 1.8e-18 64.9 8.7 6.1e-06 25.8 0.5 4.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 EFC43149.1 - 3.1e-17 61.2 6.8 1.1e-05 24.6 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFC43149.1 - 1.2e-15 57.0 5.3 1.2e-08 34.7 0.0 3.9 3 1 1 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC43149.1 - 0.00019 21.8 0.2 0.62 10.4 0.0 3.2 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC43149.1 - 0.0021 18.0 0.3 0.22 11.5 0.0 2.8 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EFC43149.1 - 0.0025 18.0 0.8 8.1 6.7 0.0 3.3 3 0 0 3 3 3 1 Dockerin type I domain UPF0731 PF14982.6 EFC43150.1 - 0.16 12.2 0.1 0.43 10.8 0.1 1.7 1 0 0 1 1 1 0 UPF0731 family tRNA-synt_2c PF01411.19 EFC43151.1 - 1.4e-213 710.4 0.7 1.4e-213 710.4 0.7 1.8 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 EFC43151.1 - 2.2e-15 56.4 0.1 5.3e-15 55.2 0.1 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 EFC43151.1 - 1.9e-14 54.3 1.0 1.9e-14 54.3 1.0 2.1 2 0 0 2 2 2 1 DHHA1 domain Carmo_coat_C PF08462.10 EFC43151.1 - 0.15 12.2 0.0 0.41 10.8 0.0 1.7 1 0 0 1 1 1 0 Carmovirus coat protein TRAM_LAG1_CLN8 PF03798.16 EFC43152.1 - 6.5e-39 133.7 29.8 6.5e-39 133.7 29.8 1.5 2 0 0 2 2 2 1 TLC domain Kelch_6 PF13964.6 EFC43154.1 - 0.21 11.9 8.2 8.1 6.9 0.0 4.8 6 0 0 6 6 6 0 Kelch motif DUF5122 PF17164.4 EFC43154.1 - 1.4 9.3 14.8 16 5.8 0.1 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller HMG_box PF00505.19 EFC43155.1 - 7.9e-19 67.8 3.2 2e-18 66.6 3.2 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC43155.1 - 1.9e-11 44.4 3.1 2.9e-11 43.8 2.0 1.9 2 0 0 2 2 2 1 HMG-box domain WD40 PF00400.32 EFC43157.1 - 1.6e-21 76.2 10.2 8.5e-05 23.3 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat 2OG-FeII_Oxy_3 PF13640.6 EFC43157.1 - 1.7e-10 41.6 0.0 8.8e-10 39.4 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Nup160 PF11715.8 EFC43157.1 - 9.7e-10 37.7 2.3 6.3e-06 25.1 1.3 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFC43157.1 - 0.0053 17.0 2.0 2.3 8.6 0.3 3.0 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PhyH PF05721.13 EFC43157.1 - 0.024 14.9 0.1 0.39 10.9 0.1 2.2 1 1 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) TetR_C_13 PF16925.5 EFC43157.1 - 0.034 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DNA_pol3_a_NII PF11490.8 EFC43157.1 - 1.1 9.1 5.0 4.4 7.2 0.2 2.9 2 1 1 3 3 3 0 DNA polymerase III polC-type N-terminus II Guanylate_cyc PF00211.20 EFC43158.1 - 8.7e-19 67.9 0.0 1.6e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain NMT1 PF09084.11 EFC43158.1 - 5.6e-17 62.4 0.0 1.1e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 NMT1/THI5 like Gram_pos_anchor PF00746.21 EFC43158.1 - 0.45 10.5 1.5 0.93 9.5 1.5 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Guanylate_cyc PF00211.20 EFC43159.1 - 1e-19 70.9 0.0 1.6e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain NMT1 PF09084.11 EFC43159.1 - 1e-17 64.8 0.0 2e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 NMT1/THI5 like Acetyltransf_1 PF00583.25 EFC43160.1 - 0.00022 21.4 0.0 0.00063 20.0 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFC43160.1 - 0.00034 20.5 0.0 0.00088 19.2 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EFC43160.1 - 0.00053 20.4 0.0 0.0012 19.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain B56 PF01603.20 EFC43160.1 - 0.02 13.9 1.2 1.3 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein phosphatase 2A regulatory B subunit (B56 family) Baculo_11_kDa PF06143.11 EFC43161.1 - 0.13 11.8 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family ETRAMP PF09716.10 EFC43161.1 - 0.14 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) UCH PF00443.29 EFC43162.1 - 1.2e-47 162.6 5.0 1.2e-47 162.6 5.0 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC43162.1 - 1.3e-08 34.8 7.9 1.3e-08 34.8 7.9 3.8 3 2 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Utp14 PF04615.13 EFC43162.1 - 3.8 6.0 83.1 0.018 13.6 52.1 3.2 3 0 0 3 3 3 0 Utp14 protein NHL PF01436.21 EFC43163.1 - 4.9e-05 23.2 0.0 0.18 11.9 0.0 4.2 4 0 0 4 4 4 1 NHL repeat Reg_prop PF07494.11 EFC43163.1 - 0.001 19.0 1.0 0.8 10.1 0.0 4.3 5 1 0 5 5 5 1 Two component regulator propeller DUF5050 PF16472.5 EFC43163.1 - 0.036 13.3 0.1 0.3 10.3 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5050) SGL PF08450.12 EFC43163.1 - 0.091 12.3 0.1 5 6.6 0.0 2.8 1 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Ras PF00071.22 EFC43164.1 - 1.9e-58 196.6 0.1 2.3e-58 196.4 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43164.1 - 8.3e-32 109.9 0.1 1.5e-31 109.1 0.1 1.4 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43164.1 - 1e-12 47.9 0.0 1.3e-12 47.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC43164.1 - 1.9e-06 28.0 0.0 3e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC43164.1 - 0.0012 18.8 0.1 0.027 14.4 0.1 2.2 1 1 1 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFC43164.1 - 0.0023 17.5 0.0 0.0065 16.0 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC43164.1 - 0.011 15.1 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EFC43164.1 - 0.14 12.6 0.0 0.18 12.1 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFC43164.1 - 0.16 12.4 0.2 0.32 11.5 0.2 1.7 1 1 0 1 1 1 0 ABC transporter RGS PF00615.19 EFC43165.1 - 2e-08 34.5 2.1 4.1e-08 33.5 2.1 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC43165.1 - 0.016 14.9 0.3 0.035 13.8 0.3 1.6 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Mt_ATP-synt_B PF05405.14 EFC43165.1 - 0.032 13.9 0.3 0.11 12.1 0.3 1.9 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Allexi_40kDa PF05549.11 EFC43165.1 - 0.048 13.2 1.6 0.12 11.9 1.6 1.6 1 0 0 1 1 1 0 Allexivirus 40kDa protein ELMO_CED12 PF04727.13 EFC43167.1 - 4.2e-35 121.5 0.7 7.5e-35 120.6 0.1 1.7 2 0 0 2 2 2 1 ELMO/CED-12 family PsbP PF01789.16 EFC43168.1 - 0.025 14.7 0.9 0.032 14.4 0.7 1.4 1 1 0 1 1 1 0 PsbP zf-C2H2_7 PF15269.6 EFC43168.1 - 0.12 12.4 0.6 0.26 11.4 0.6 1.6 1 1 0 1 1 1 0 Zinc-finger DUF3439 PF11921.8 EFC43168.1 - 2.8 7.9 13.7 0.68 9.9 10.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) FHA PF00498.26 EFC43169.1 - 4.9e-18 65.3 1.5 8e-18 64.6 1.5 1.4 1 1 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFC43169.1 - 7.2e-08 32.6 0.0 0.0089 16.3 0.0 2.1 1 1 1 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain NAD_Gly3P_dh_C PF07479.14 EFC43170.1 - 6.4e-50 169.1 0.7 1e-49 168.4 0.4 1.6 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 EFC43170.1 - 3.2e-36 124.7 0.0 9.3e-36 123.2 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 EFC43170.1 - 0.05 13.2 0.0 0.094 12.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.6 EFC43170.1 - 0.055 12.7 0.0 0.083 12.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Bombolitin PF08096.11 EFC43170.1 - 0.13 12.6 0.1 0.56 10.6 0.0 2.1 2 0 0 2 2 2 0 Bombolitin family F420_oxidored PF03807.17 EFC43170.1 - 0.15 12.7 0.0 0.39 11.3 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PdaC PF13739.6 EFC43170.1 - 2.7 9.0 5.5 4.4 8.3 1.8 2.4 2 1 0 2 2 2 0 Deacetylase PdaC Adaptin_N PF01602.20 EFC43171.1 - 1.5e-86 291.1 11.7 1.9e-86 290.7 11.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFC43171.1 - 2.5e-36 125.2 4.7 3.3e-36 124.8 2.3 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 EFC43171.1 - 2.2e-14 53.5 1.4 3.3e-14 52.9 0.3 1.8 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 EFC43171.1 - 4.4e-09 36.6 0.0 2.6e-05 24.5 0.0 4.0 3 1 1 4 4 4 1 HEAT repeats HEAT PF02985.22 EFC43171.1 - 8.6e-07 28.7 0.2 0.0024 18.0 0.0 3.6 3 0 0 3 3 3 2 HEAT repeat RTP1_C1 PF10363.9 EFC43171.1 - 0.00016 21.8 0.8 0.0058 16.8 0.2 3.0 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 EFC43171.1 - 0.00097 19.4 0.1 0.34 11.3 0.0 3.0 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion API5 PF05918.11 EFC43171.1 - 0.0016 17.4 0.4 0.38 9.5 0.1 2.4 2 0 0 2 2 2 2 Apoptosis inhibitory protein 5 (API5) CLASP_N PF12348.8 EFC43171.1 - 0.061 12.9 0.0 0.45 10.0 0.0 2.5 2 0 0 2 2 2 0 CLASP N terminal DUF503 PF04456.12 EFC43171.1 - 0.098 12.5 0.6 0.47 10.3 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF503) DUF4116 PF13475.6 EFC43172.1 - 4.9e-07 29.4 17.7 0.0069 16.1 3.8 6.2 5 1 1 6 6 6 3 Domain of unknown function (DUF4116) Ndr PF03096.14 EFC43172.1 - 0.026 13.2 0.2 0.049 12.3 0.2 1.4 1 0 0 1 1 1 0 Ndr family F-box_4 PF15966.5 EFC43172.1 - 0.029 14.2 0.8 6.5 6.7 0.0 3.1 3 0 0 3 3 3 0 F-box Tweety PF04906.13 EFC43172.1 - 0.041 12.6 0.3 0.19 10.4 0.0 2.0 2 0 0 2 2 2 0 Tweety 14-3-3 PF00244.20 EFC43173.1 - 2.2e-104 347.8 6.4 2.5e-104 347.6 6.4 1.0 1 0 0 1 1 1 1 14-3-3 protein DUF919 PF06034.11 EFC43173.1 - 0.14 12.0 1.6 0.38 10.6 1.6 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) TPR_19 PF14559.6 EFC43173.1 - 0.18 12.3 1.4 0.35 11.4 0.2 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat RCC1 PF00415.18 EFC43174.1 - 2e-16 60.3 0.0 1e-09 38.9 0.0 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC43174.1 - 1e-09 38.6 5.8 1.6e-08 34.8 0.8 3.0 2 1 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 EFC43174.1 - 4.1e-08 32.8 0.6 1.7e-05 24.5 0.0 3.3 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat BRCT_2 PF16589.5 EFC43174.1 - 0.011 16.1 0.4 2.2 8.7 0.1 2.9 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 EFC43174.1 - 0.026 14.4 0.0 0.059 13.3 0.0 1.6 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain DUF1533 PF07550.11 EFC43174.1 - 0.86 9.5 4.3 28 4.7 0.5 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1533) RCC1 PF00415.18 EFC43175.1 - 1.9e-57 191.7 28.6 7.1e-13 49.0 0.0 14.6 13 2 0 13 13 13 10 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43175.1 - 3e-25 87.4 34.1 3.6e-06 26.6 0.2 14.8 15 1 0 15 15 15 7 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC43175.1 - 1e-09 38.6 50.5 3.8e-05 24.0 11.1 3.5 3 0 0 3 3 3 3 EGF-like domain DUF5074 PF16819.5 EFC43175.1 - 0.067 13.2 0.3 0.067 13.2 0.3 3.3 4 1 1 5 5 5 0 Domain of unknown function (DUF5074) Laminin_EGF PF00053.24 EFC43175.1 - 0.08 13.1 37.4 0.16 12.1 8.7 3.4 2 1 1 3 3 3 0 Laminin EGF domain MalM PF07148.12 EFC43176.1 - 0.2 11.4 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Maltose operon periplasmic protein precursor (MalM) adh_short PF00106.25 EFC43178.1 - 3.6e-41 140.8 0.2 5.4e-41 140.2 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43178.1 - 6.6e-30 104.4 0.0 8.9e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43178.1 - 2.5e-07 30.8 0.0 4.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC43178.1 - 0.00022 20.5 0.6 0.00035 19.8 0.6 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EFC43178.1 - 0.00034 20.9 0.5 0.0017 18.6 0.3 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N PF00107.26 EFC43178.1 - 0.0025 17.8 0.1 0.0046 16.9 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 EFC43178.1 - 0.0064 16.3 0.1 0.014 15.1 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2855) Shikimate_DH PF01488.20 EFC43178.1 - 0.0073 16.4 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EFC43178.1 - 0.014 14.9 0.4 0.024 14.1 0.4 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC43178.1 - 0.015 15.2 0.1 0.021 14.7 0.1 1.3 1 1 0 1 1 1 0 NAD(P)H-binding 3HCDH_N PF02737.18 EFC43178.1 - 0.015 15.2 0.2 0.023 14.6 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 EFC43178.1 - 0.094 12.0 0.1 0.21 10.9 0.1 1.6 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TANGO2 PF05742.12 EFC43179.1 - 1.7e-17 64.3 0.6 2.2e-17 63.9 0.6 1.2 1 0 0 1 1 1 1 Transport and Golgi organisation 2 DUF3387 PF11867.8 EFC43179.1 - 0.043 13.2 6.3 0.061 12.7 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3387) SRI PF08236.11 EFC43179.1 - 0.093 12.9 2.0 0.21 11.8 2.0 1.7 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Cytokin_check_N PF10407.9 EFC43179.1 - 0.12 12.3 0.5 0.12 12.3 0.5 2.3 3 0 0 3 3 3 0 Cdc14 phosphatase binding protein N-terminus PfkB PF00294.24 EFC43180.1 - 9e-47 159.8 0.4 1e-46 159.6 0.4 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Cation_efflux PF01545.21 EFC43181.1 - 1.1e-48 165.6 15.5 1.3e-48 165.4 15.5 1.1 1 0 0 1 1 1 1 Cation efflux family MFS_2 PF13347.6 EFC43181.1 - 0.0096 14.5 7.1 0.015 13.9 7.1 1.3 1 1 0 1 1 1 1 MFS/sugar transport protein F-box PF00646.33 EFC43182.1 - 0.00012 21.8 0.8 0.00072 19.4 0.1 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC43182.1 - 0.0015 18.4 0.7 0.0095 15.8 0.0 2.6 3 0 0 3 3 3 1 F-box-like PRANC PF09372.10 EFC43182.1 - 0.024 14.9 7.9 0.11 12.8 0.0 3.8 4 0 0 4 4 4 0 PRANC domain GST_C_3 PF14497.6 EFC43183.1 - 8.6e-11 41.9 0.1 5.6e-10 39.3 0.0 2.0 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC43183.1 - 6.4e-07 29.5 0.0 1.3e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC43183.1 - 0.00038 20.4 0.0 0.0007 19.6 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.13 EFC43183.1 - 0.0093 15.8 0.1 0.027 14.3 0.0 1.7 1 1 1 2 2 2 1 Glutaredoxin 2, C terminal domain HTH_40 PF14493.6 EFC43183.1 - 0.12 12.8 0.2 0.38 11.2 0.0 1.9 3 0 0 3 3 3 0 Helix-turn-helix domain Lipase_GDSL PF00657.22 EFC43184.1 - 1.8e-08 34.6 0.0 2.7e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Cu-binding_MopE PF11617.8 EFC43184.1 - 8.3e-05 22.7 0.2 0.00019 21.5 0.2 1.6 1 0 0 1 1 1 1 Putative metal-binding motif SapB_2 PF03489.17 EFC43184.1 - 0.00017 21.6 0.3 0.00052 20.1 0.3 1.9 1 0 0 1 1 1 1 Saposin-like type B, region 2 Hydrolase_4 PF12146.8 EFC43186.1 - 4.3e-05 22.9 0.0 0.00011 21.5 0.0 1.7 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC43186.1 - 0.058 13.0 0.0 0.2 11.3 0.0 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold EF-hand_7 PF13499.6 EFC43187.1 - 1.1e-30 105.9 8.7 9.5e-16 58.0 1.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC43187.1 - 1.4e-30 102.5 14.6 8.5e-08 31.2 0.2 4.1 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EFC43187.1 - 2.5e-24 83.1 13.3 1.1e-07 31.1 0.7 4.3 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFC43187.1 - 2.4e-22 77.3 10.4 1.8e-06 27.2 0.5 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFC43187.1 - 1.4e-19 69.6 19.3 1.2e-07 31.5 0.2 4.1 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC43187.1 - 1.1e-08 35.4 0.3 3.3e-05 24.2 0.0 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 EFC43187.1 - 3.1e-06 27.4 0.6 0.0023 18.2 0.1 2.4 2 1 0 2 2 2 2 EF-hand domain Caleosin PF05042.13 EFC43187.1 - 0.00051 20.0 1.8 0.27 11.1 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein EF-hand_11 PF08976.11 EFC43187.1 - 0.00057 20.7 0.3 0.044 14.6 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 EFC43187.1 - 0.0024 17.8 6.6 1.4 8.9 0.1 3.6 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 EFC43187.1 - 0.025 14.9 1.1 2.6 8.5 0.1 2.5 2 1 1 3 3 3 0 EF-hand domain p25-alpha PF05517.12 EFC43187.1 - 0.068 13.3 0.3 0.21 11.7 0.1 1.8 2 0 0 2 2 2 0 p25-alpha SNARE PF05739.19 EFC43188.1 - 3.7e-10 39.7 0.0 1.1e-09 38.1 0.0 1.9 1 0 0 1 1 1 1 SNARE domain Adeno_E3 PF06040.11 EFC43188.1 - 0.074 13.2 0.5 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 Adenovirus E3 protein Swi5 PF07061.11 EFC43188.1 - 0.26 11.4 0.1 0.26 11.4 0.1 3.6 2 1 1 3 3 3 0 Swi5 Cytochrom_C_2 PF01322.20 EFC43188.1 - 0.5 11.3 6.3 0.071 14.0 1.7 2.0 2 1 0 2 2 2 0 Cytochrome C' DUF4481 PF14800.6 EFC43188.1 - 0.5 9.8 4.8 0.94 8.9 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) Arc_PepC_II PF06847.11 EFC43188.1 - 2.2 8.9 10.4 12 6.5 4.4 3.2 2 1 1 3 3 3 0 Archaeal Peptidase A24 C-terminus Type II Peptidase_M16 PF00675.20 EFC43189.1 - 2e-41 141.4 0.3 1.4e-38 132.2 0.0 2.5 3 0 0 3 3 3 2 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFC43189.1 - 1.1e-28 100.4 0.1 3.3e-28 98.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain M16C_assoc PF08367.11 EFC43189.1 - 0.083 12.0 0.0 0.2 10.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase M16C associated DKCLD PF08068.12 EFC43190.1 - 2.2e-32 110.9 0.4 6.7e-30 103.0 0.1 3.0 3 0 0 3 3 3 1 DKCLD (NUC011) domain TruB_N PF01509.18 EFC43190.1 - 1.5e-22 80.5 0.9 1.6e-19 70.8 0.9 3.5 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 EFC43190.1 - 4.4e-18 65.0 0.4 9.3e-18 64.0 0.4 1.6 1 0 0 1 1 1 1 PUA domain TruB_C_2 PF16198.5 EFC43190.1 - 3.1e-17 62.5 0.2 6.3e-17 61.5 0.2 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain UPF0113 PF03657.13 EFC43190.1 - 0.093 13.0 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 UPF0113 PUA domain AC_N PF16214.5 EFC43190.1 - 0.26 10.4 1.9 0.39 9.8 1.9 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region KTI12 PF08433.10 EFC43191.1 - 2.5e-77 260.0 0.6 2.8e-77 259.8 0.6 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EFC43191.1 - 7.2e-05 23.0 0.0 0.00012 22.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC43191.1 - 0.0007 20.1 0.0 0.0012 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFC43191.1 - 0.1 13.0 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Proteasome PF00227.26 EFC43192.1 - 4e-37 127.5 0.0 4.6e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Cornichon PF03311.14 EFC43193.1 - 5.6e-17 62.2 6.4 6.4e-17 62.0 6.4 1.0 1 0 0 1 1 1 1 Cornichon protein MFS_1 PF07690.16 EFC43194.1 - 1.7e-36 125.9 38.0 1.6e-27 96.4 18.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFC43194.1 - 4.5e-11 42.2 12.7 8.4e-08 31.5 6.0 2.5 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 EFC43194.1 - 1.3e-08 34.1 14.1 1.2e-07 31.0 0.5 3.7 3 1 0 3 3 3 2 Sugar (and other) transporter FixP_N PF14715.6 EFC43194.1 - 0.052 13.3 0.6 0.052 13.3 0.6 3.5 4 0 0 4 4 4 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Peptidase_S64 PF08192.11 EFC43195.1 - 0.25 9.8 9.8 0.37 9.2 9.8 1.2 1 0 0 1 1 1 0 Peptidase family S64 LRR_9 PF14580.6 EFC43195.1 - 0.38 10.2 3.8 0.79 9.2 1.6 2.3 2 0 0 2 2 2 0 Leucine-rich repeat LRR_8 PF13855.6 EFC43195.1 - 0.53 10.1 3.3 1.8 8.4 0.7 2.9 3 1 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 EFC43195.1 - 0.7 10.4 16.9 1.4 9.5 1.0 4.9 5 1 2 7 7 7 0 Leucine Rich repeats (2 copies) AAA_33 PF13671.6 EFC43196.1 - 1.9e-19 70.3 0.0 2.3e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC43196.1 - 9.3e-06 26.2 0.0 1.6e-05 25.5 0.0 1.4 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.12 EFC43196.1 - 5.3e-05 22.6 0.5 0.0003 20.1 0.5 1.8 1 1 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 EFC43196.1 - 0.00056 20.3 0.1 0.0011 19.4 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 EFC43196.1 - 0.0037 16.5 0.1 0.006 15.8 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 EFC43196.1 - 0.0059 16.9 0.1 0.0084 16.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EFC43196.1 - 0.01 15.8 0.1 0.015 15.2 0.1 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 EFC43196.1 - 0.011 15.8 0.0 0.018 15.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 EFC43196.1 - 0.013 15.0 0.0 0.017 14.6 0.0 1.2 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_29 PF13555.6 EFC43196.1 - 0.019 14.7 1.0 0.04 13.7 1.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 EFC43196.1 - 0.02 14.8 0.0 0.03 14.3 0.0 1.4 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_17 PF13207.6 EFC43196.1 - 0.022 15.2 0.1 0.043 14.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFC43196.1 - 0.034 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Ploopntkinase3 PF18751.1 EFC43196.1 - 0.042 13.7 0.0 0.064 13.2 0.0 1.4 1 1 0 1 1 1 0 P-loop Nucleotide Kinase3 RNA_helicase PF00910.22 EFC43196.1 - 0.055 13.9 0.8 0.15 12.5 0.8 1.9 1 1 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 EFC43196.1 - 0.061 13.0 0.2 0.092 12.5 0.2 1.4 1 1 0 1 1 1 0 AAA domain APS_kinase PF01583.20 EFC43196.1 - 0.063 13.2 0.2 0.12 12.3 0.1 1.5 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_30 PF13604.6 EFC43196.1 - 0.067 12.9 0.5 0.53 10.0 0.1 2.3 1 1 1 2 2 2 0 AAA domain CPT PF07931.12 EFC43196.1 - 0.085 12.7 0.4 0.17 11.7 0.4 1.8 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.27 EFC43196.1 - 0.098 13.2 2.4 0.17 12.4 2.4 1.7 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 EFC43196.1 - 0.13 12.1 0.3 0.26 11.2 0.1 1.6 2 0 0 2 2 2 0 RsgA GTPase AAA_28 PF13521.6 EFC43196.1 - 0.15 12.3 0.0 0.22 11.8 0.0 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 EFC43196.1 - 0.18 11.5 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain Methyltransf_25 PF13649.6 EFC43197.1 - 1.8e-18 67.0 0.0 4.2e-18 65.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC43197.1 - 1.2e-16 60.9 0.0 1.5e-16 60.5 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC43197.1 - 5.6e-15 55.8 0.0 1.1e-14 54.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC43197.1 - 4.9e-14 52.2 0.1 9.2e-13 48.1 0.1 2.1 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC43197.1 - 5.3e-13 49.1 0.0 8.1e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC43197.1 - 1.2e-08 35.6 0.0 1.9e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFC43197.1 - 0.00085 19.3 0.1 0.002 18.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFC43197.1 - 0.00092 19.2 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC43197.1 - 0.0091 15.6 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 EFC43197.1 - 0.016 14.9 0.0 0.039 13.7 0.0 1.5 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 PCMT PF01135.19 EFC43197.1 - 0.091 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_8 PF05148.15 EFC43197.1 - 0.091 12.6 0.0 0.53 10.1 0.0 2.2 3 0 0 3 3 3 0 Hypothetical methyltransferase PrmA PF06325.13 EFC43197.1 - 0.11 11.9 0.3 0.27 10.6 0.1 1.7 2 1 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 EFC43198.1 - 2.2e-13 50.6 0.0 4.5e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain WBS_methylT PF12589.8 EFC43198.1 - 4.2e-13 49.8 1.3 6.4e-13 49.3 1.3 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_25 PF13649.6 EFC43198.1 - 2.8e-11 44.0 0.0 5.3e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC43198.1 - 1.5e-06 28.9 0.0 2.5e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC43198.1 - 2.8e-06 27.3 0.0 5.3e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC43198.1 - 7.2e-05 22.6 0.0 0.00012 21.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC43198.1 - 0.0061 15.9 0.0 0.009 15.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 EFC43198.1 - 0.012 15.4 0.0 0.018 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 EFC43198.1 - 0.051 12.9 0.0 0.068 12.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase N6_N4_Mtase PF01555.18 EFC43198.1 - 0.066 12.9 0.1 0.92 9.2 0.0 2.1 2 1 0 2 2 2 0 DNA methylase Na_sulph_symp PF00939.19 EFC43199.1 - 1.3e-76 258.6 17.3 1.5e-76 258.4 17.3 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 EFC43199.1 - 5.5e-35 121.0 7.3 5.5e-35 121.0 7.3 2.5 1 1 1 2 2 2 2 Citrate transporter GWT1 PF06423.12 EFC43199.1 - 2.4 8.3 6.7 0.38 10.9 1.2 2.5 2 1 1 3 3 3 0 GWT1 YSIRK_signal PF04650.17 EFC43199.1 - 5.8 6.9 6.6 15 5.6 0.9 3.4 3 0 0 3 3 3 0 YSIRK type signal peptide Acetyltransf_1 PF00583.25 EFC43200.1 - 7.2e-17 61.7 0.0 1.2e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC43200.1 - 7.1e-12 45.4 1.0 1.4e-11 44.4 0.1 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC43200.1 - 2e-11 44.2 0.0 4.9e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC43200.1 - 5.2e-07 29.9 0.1 1.6e-06 28.3 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC43200.1 - 8.5e-07 29.7 0.1 1.3e-06 29.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC43200.1 - 0.0011 19.1 0.0 0.016 15.3 0.0 2.4 1 1 1 2 2 2 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFC43200.1 - 0.017 15.1 0.1 0.033 14.2 0.1 1.4 1 0 0 1 1 1 0 FR47-like protein Pfk_N PF18468.1 EFC43200.1 - 0.039 14.4 0.9 1.5 9.3 0.1 2.9 2 1 1 3 3 3 0 Phosphofructokinase N-terminal domain yeast Acetyltransf_9 PF13527.7 EFC43200.1 - 0.08 13.0 0.0 0.27 11.3 0.0 2.0 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF3567 PF12091.8 EFC43202.1 - 0.078 13.1 1.9 0.096 12.8 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3567) Phage_XkdX PF09693.10 EFC43202.1 - 1.3 9.1 5.5 24 5.1 0.2 4.0 4 0 0 4 4 4 0 Phage uncharacterised protein (Phage_XkdX) HMG_box PF00505.19 EFC43203.1 - 2.4e-36 124.0 8.3 4.6e-23 81.4 0.9 2.8 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC43203.1 - 1.4e-24 86.5 13.4 1.2e-14 54.6 0.7 2.8 1 1 1 3 3 3 2 HMG-box domain CHDNT PF08073.12 EFC43203.1 - 0.00014 21.8 0.7 0.00031 20.6 0.0 1.9 2 0 0 2 2 2 1 CHDNT (NUC034) domain KRAB PF01352.27 EFC43203.1 - 0.16 11.7 0.0 0.87 9.3 0.1 2.0 2 0 0 2 2 2 0 KRAB box Mlh1_C PF16413.5 EFC43203.1 - 3 7.1 7.7 0.14 11.5 0.6 1.9 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus AAA PF00004.29 EFC43204.1 - 2.2e-43 147.8 0.1 7.8e-43 146.1 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC43204.1 - 5.3e-09 35.7 0.1 1.1e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFC43204.1 - 6.4e-09 35.6 0.3 1.5e-08 34.5 0.3 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 EFC43204.1 - 4.2e-08 33.5 0.3 1.3e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFC43204.1 - 9.1e-06 25.7 0.0 4.9e-05 23.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC43204.1 - 6.8e-05 23.2 0.1 0.022 15.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFC43204.1 - 0.00019 21.2 0.1 0.00049 19.9 0.0 1.7 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFC43204.1 - 0.00027 21.4 0.0 0.0032 17.9 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EFC43204.1 - 0.00029 21.0 0.0 0.00068 19.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFC43204.1 - 0.0024 17.2 0.1 0.23 10.8 0.0 2.5 2 0 0 2 2 2 1 KaiC PhoH PF02562.16 EFC43204.1 - 0.0025 17.3 0.0 0.051 13.0 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein Troponin PF00992.20 EFC43204.1 - 0.0026 18.1 2.7 0.0034 17.7 0.9 2.0 2 0 0 2 2 2 1 Troponin IstB_IS21 PF01695.17 EFC43204.1 - 0.0028 17.4 0.0 0.0057 16.4 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 EFC43204.1 - 0.0046 16.2 0.0 0.01 15.1 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 EFC43204.1 - 0.005 16.2 0.2 0.013 14.9 0.1 1.7 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFC43204.1 - 0.015 15.6 0.0 0.027 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DASH_Dad2 PF08654.10 EFC43204.1 - 0.017 15.5 0.8 0.052 14.0 0.6 1.9 2 0 0 2 2 1 0 DASH complex subunit Dad2 RNA_helicase PF00910.22 EFC43204.1 - 0.017 15.5 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 EFC43204.1 - 0.017 15.0 0.0 0.04 13.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 EFC43204.1 - 0.018 14.9 0.1 0.6 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 EFC43204.1 - 0.019 14.7 0.0 0.38 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC43204.1 - 0.024 15.2 0.0 0.098 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 EFC43204.1 - 0.037 14.1 0.0 0.11 12.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain TsaE PF02367.17 EFC43204.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2072 PF09845.9 EFC43204.1 - 0.06 13.6 0.7 0.14 12.4 0.7 1.6 1 0 0 1 1 1 0 Zn-ribbon containing protein Prot_ATP_OB_N PF17758.1 EFC43204.1 - 0.062 13.0 0.0 0.17 11.5 0.0 1.7 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Zeta_toxin PF06414.12 EFC43204.1 - 0.063 12.5 0.0 0.18 11.1 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin Snapin_Pallidin PF14712.6 EFC43204.1 - 0.07 13.6 2.1 0.24 11.9 2.1 1.9 1 0 0 1 1 1 0 Snapin/Pallidin Sigma54_activat PF00158.26 EFC43204.1 - 0.079 12.7 0.1 0.43 10.3 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain APG6_N PF17675.1 EFC43204.1 - 0.087 13.3 1.4 0.2 12.2 1.4 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Parvo_NS1 PF01057.17 EFC43204.1 - 0.12 11.4 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 EFC43204.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Phage_GP20 PF06810.11 EFC43204.1 - 0.24 11.2 2.2 0.93 9.3 2.2 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 AAA PF00004.29 EFC43205.1 - 4.5e-11 43.3 0.2 0.00018 22.0 0.0 3.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFC43205.1 - 3e-09 36.6 0.1 2.9e-05 23.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 EFC43205.1 - 4.4e-09 36.5 0.0 1.6e-06 28.1 0.0 4.1 5 0 0 5 5 4 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 EFC43205.1 - 1.3e-06 28.6 0.4 2.1 8.4 0.0 4.5 3 0 0 3 3 3 3 Sigma-54 interaction domain AAA_14 PF13173.6 EFC43205.1 - 4.5e-06 26.7 1.2 0.00024 21.2 0.0 4.2 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.6 EFC43205.1 - 0.00089 19.5 1.7 0.41 10.9 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 EFC43205.1 - 0.0015 19.0 0.0 0.17 12.2 0.0 3.3 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 EFC43205.1 - 0.002 18.5 0.0 1.3 9.5 0.0 4.1 2 0 0 2 2 2 1 RNA helicase NTPase_1 PF03266.15 EFC43205.1 - 0.0027 17.6 2.3 0.36 10.7 0.1 4.1 4 0 0 4 4 4 1 NTPase Viral_helicase1 PF01443.18 EFC43205.1 - 0.031 14.0 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EFC43205.1 - 0.056 13.9 1.6 0.85 10.1 0.1 3.2 3 0 0 3 3 3 0 ABC transporter NACHT PF05729.12 EFC43205.1 - 0.1 12.5 0.8 1.3 9.0 0.1 3.0 3 0 0 3 3 3 0 NACHT domain AAA_18 PF13238.6 EFC43205.1 - 0.11 13.1 0.1 1.8 9.1 0.0 3.2 2 0 0 2 2 2 0 AAA domain DASH_Dad4 PF08650.10 EFC43205.1 - 0.72 9.9 9.8 0.088 12.8 0.6 3.9 2 0 0 2 2 2 0 DASH complex subunit Dad4 Rad17 PF03215.15 EFC43205.1 - 1.6 8.6 10.0 1.7 8.5 0.0 4.5 5 0 0 5 5 4 0 Rad17 P-loop domain Peptidase_M9_N PF08453.10 EFC43206.1 - 0.0035 17.1 1.0 0.0047 16.7 1.0 1.2 1 0 0 1 1 1 1 Peptidase family M9 N-terminal rRNA_proc-arch PF13234.6 EFC43206.1 - 0.011 15.7 3.5 0.086 12.8 0.1 2.3 2 0 0 2 2 2 0 rRNA-processing arch domain Phage_Mu_Gam PF07352.12 EFC43206.1 - 0.024 14.5 2.7 0.035 14.0 1.8 1.7 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein HBM PF16591.5 EFC43206.1 - 0.045 13.2 0.2 0.067 12.6 0.2 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain Dak1_2 PF13684.6 EFC43206.1 - 0.047 12.8 1.8 0.072 12.2 0.2 1.8 1 1 1 2 2 2 0 Dihydroxyacetone kinase family BCDHK_Adom3 PF10436.9 EFC43206.1 - 0.065 13.1 1.1 0.51 10.2 1.1 2.0 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Ribosomal_L27A PF00828.19 EFC43207.1 - 0.39 11.4 1.1 0.6 10.8 0.4 1.7 2 0 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ank_2 PF12796.7 EFC43209.1 - 1.6e-26 92.7 2.5 2.8e-07 31.0 0.0 7.0 3 1 4 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC43209.1 - 6.8e-23 80.7 1.3 3.5e-07 30.7 0.0 7.0 5 1 2 7 7 7 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC43209.1 - 9e-17 60.9 0.6 0.023 15.0 0.0 8.1 6 2 3 9 9 9 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC43209.1 - 1.1e-13 50.0 8.8 0.018 15.6 0.1 9.9 10 0 0 10 10 10 2 Ankyrin repeat zf-MYND PF01753.18 EFC43209.1 - 7.4e-07 29.2 18.1 1.7e-06 28.0 18.1 1.6 1 0 0 1 1 1 1 MYND finger Ank PF00023.30 EFC43209.1 - 1.2e-06 28.6 5.4 1.2 9.7 0.2 6.3 4 1 0 4 4 4 2 Ankyrin repeat SAM_1 PF00536.30 EFC43210.1 - 1.6e-09 38.1 0.3 5.7e-09 36.3 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) RGS PF00615.19 EFC43210.1 - 0.00012 22.4 4.4 0.00012 22.4 4.4 2.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain SAM_2 PF07647.17 EFC43210.1 - 0.0029 17.7 0.1 0.008 16.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RasGAP PF00616.19 EFC43210.1 - 0.0037 17.0 2.8 0.0094 15.7 2.8 1.7 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase PMC2NT PF08066.12 EFC43210.1 - 0.0058 17.3 2.1 3.5 8.4 0.1 2.7 2 1 0 2 2 2 2 PMC2NT (NUC016) domain MA3 PF02847.17 EFC43210.1 - 0.11 12.5 2.5 9 6.3 0.0 3.5 5 1 0 5 5 5 0 MA3 domain RhoGAP PF00620.27 EFC43211.1 - 1.5e-19 70.3 0.1 4.8e-19 68.7 0.1 1.9 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 EFC43211.1 - 9.2e-19 67.4 24.7 2.1e-10 40.7 8.5 2.6 2 0 0 2 2 2 2 LIM domain TPR_MLP1_2 PF07926.12 EFC43211.1 - 0.0028 17.7 11.2 0.0028 17.7 11.2 2.9 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 EFC43211.1 - 3.7 6.5 20.8 0.008 15.3 8.5 2.7 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 TNFR_c6 PF00020.18 EFC43211.1 - 5.7 7.4 10.8 10 6.6 0.4 3.2 3 0 0 3 3 3 0 TNFR/NGFR cysteine-rich region zf-HYPF PF07503.12 EFC43211.1 - 6.8 6.6 9.1 5.9 6.8 0.9 2.9 2 0 0 2 2 2 0 HypF finger BRCT PF00533.26 EFC43212.1 - 3.8e-13 49.6 1.0 6.1e-12 45.8 0.1 3.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC43212.1 - 9.2e-09 35.6 0.1 2.3e-08 34.3 0.1 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain F-box PF00646.33 EFC43212.1 - 8.9e-05 22.3 0.3 0.00032 20.5 0.3 2.0 1 0 0 1 1 1 1 F-box domain PTCB-BRCT PF12738.7 EFC43212.1 - 0.00013 21.8 0.0 0.00032 20.6 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain F-box-like PF12937.7 EFC43212.1 - 0.0012 18.7 0.1 0.0033 17.3 0.1 1.8 1 0 0 1 1 1 1 F-box-like BRCT_3 PF18428.1 EFC43212.1 - 0.043 13.9 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain FAM176 PF14851.6 EFC43212.1 - 1.6 8.4 8.0 1.4 8.6 2.6 2.6 2 0 0 2 2 2 0 FAM176 family DUF4611 PF15387.6 EFC43212.1 - 5.3 7.3 8.4 0.58 10.4 0.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF4116 PF13475.6 EFC43214.1 - 5.9e-51 170.0 7.7 1.1e-15 57.1 0.1 6.1 4 1 1 6 6 6 5 Domain of unknown function (DUF4116) zf-MYND PF01753.18 EFC43215.1 - 3.4e-11 43.0 17.4 9.1e-11 41.7 17.4 1.8 1 0 0 1 1 1 1 MYND finger MRI PF15325.6 EFC43216.1 - 0.14 13.2 1.8 0.3 12.2 1.8 1.6 1 0 0 1 1 1 0 Modulator of retrovirus infection F-box-like PF12937.7 EFC43217.1 - 0.0038 17.1 0.0 0.012 15.4 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFC43217.1 - 0.041 13.5 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box F-box PF00646.33 EFC43217.1 - 0.078 12.9 0.0 0.25 11.3 0.0 1.9 1 0 0 1 1 1 0 F-box domain NHL PF01436.21 EFC43218.1 - 1.1e-06 28.3 0.0 2.3e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 NHL repeat ANAPC4_WD40 PF12894.7 EFC43218.1 - 0.14 12.4 0.1 0.53 10.6 0.1 2.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RGS PF00615.19 EFC43219.1 - 1.2e-09 38.4 2.3 4.3e-09 36.7 2.3 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain RGS PF00615.19 EFC43220.1 - 7.3e-11 42.4 5.5 1e-09 38.7 5.5 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF3021 PF11457.8 EFC43221.1 - 0.0073 16.6 20.8 1.3 9.4 2.4 3.3 3 0 0 3 3 3 3 Protein of unknown function (DUF3021) DUF5305 PF17231.2 EFC43222.1 - 0.62 9.4 4.4 0.19 11.1 1.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5305) DUF5326 PF17260.2 EFC43222.1 - 5.6 7.2 6.6 1.3 9.2 0.5 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5326) Actin PF00022.19 EFC43223.1 - 5.3e-118 394.2 0.0 3.1e-117 391.6 0.0 1.8 1 1 0 1 1 1 1 Actin Ras PF00071.22 EFC43224.1 - 2.1e-14 53.4 0.1 5.6e-14 52.0 0.1 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC43224.1 - 2.5e-06 27.7 0.0 5.8e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC43224.1 - 4.9e-05 22.7 5.9 0.047 12.9 0.1 2.6 2 1 1 3 3 3 2 G-protein alpha subunit RsgA_GTPase PF03193.16 EFC43224.1 - 0.00013 21.9 0.1 0.16 11.9 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC43224.1 - 0.0018 18.4 0.0 0.0048 17.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFC43224.1 - 0.0046 17.5 0.0 0.011 16.3 0.0 1.6 1 1 0 1 1 1 1 ABC transporter PX PF00787.24 EFC43224.1 - 0.0078 16.2 3.0 0.072 13.1 0.1 3.1 3 0 0 3 3 3 1 PX domain GTP_EFTU PF00009.27 EFC43224.1 - 0.0086 15.6 0.0 0.048 13.2 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFC43224.1 - 0.013 15.3 0.1 0.18 11.6 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 EFC43224.1 - 0.014 14.9 0.0 0.058 12.8 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_18 PF13238.6 EFC43224.1 - 0.044 14.3 0.0 0.14 12.7 0.0 2.0 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 EFC43224.1 - 0.061 13.1 0.2 3.5 7.4 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein F-box PF00646.33 EFC43224.1 - 2.6 8.0 4.9 0.5 10.3 0.2 2.3 3 0 0 3 3 3 0 F-box domain RasGEF PF00617.19 EFC43225.1 - 4.6e-44 150.7 2.8 1.7e-43 148.9 2.8 2.1 1 0 0 1 1 1 1 RasGEF domain DOCK-C2 PF14429.6 EFC43225.1 - 1e-32 113.6 1.9 1e-32 113.6 1.9 2.8 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC43225.1 - 1.1e-06 28.8 0.2 1.4e-05 25.2 0.2 3.2 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF4698 PF15769.5 EFC43226.1 - 2.3 7.2 12.2 3.6 6.5 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Glyco_transf_4 PF13439.6 EFC43227.1 - 6.2e-09 36.1 0.0 8.1e-08 32.4 0.0 2.8 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 EFC43227.1 - 0.00018 21.6 0.4 0.00073 19.6 0.4 2.0 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_4_4 PF13579.6 EFC43227.1 - 0.00055 20.4 0.0 0.0057 17.1 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain HisK_sensor PF18698.1 EFC43227.1 - 0.14 12.5 3.3 7 7.0 0.2 3.3 3 0 0 3 3 3 0 Histidine kinase sensor domain SF3A3 PF16837.5 EFC43227.1 - 4.4 7.9 6.8 19 5.8 0.1 4.3 4 1 0 4 4 4 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Opacity PF02462.15 EFC43228.1 - 0.15 12.2 0.2 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Opacity family porin protein LRR_6 PF13516.6 EFC43229.1 - 8.7e-35 115.8 6.7 7.8e-06 25.5 0.0 6.4 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC43229.1 - 5.7e-25 86.8 19.6 3.1e-09 36.5 1.3 3.7 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC43229.1 - 1.6e-19 69.7 12.3 5.4e-06 26.7 0.9 4.4 2 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC43229.1 - 4.4e-12 44.8 3.3 2.3 9.1 0.0 7.2 7 0 0 7 7 7 2 Leucine Rich Repeat DUF4347 PF14252.6 EFC43229.1 - 0.00023 21.0 0.8 4.9 7.0 0.2 4.9 1 1 2 3 3 3 1 Domain of unknown function (DUF4347) LRR_9 PF14580.6 EFC43229.1 - 0.0011 18.6 2.7 0.0062 16.0 0.9 2.3 1 1 1 2 2 2 2 Leucine-rich repeat NKWYS PF10364.9 EFC43229.1 - 0.0055 16.8 7.2 0.066 13.3 0.6 3.0 1 1 2 3 3 3 2 Putative capsular polysaccharide synthesis protein RNase_Zc3h12a_2 PF14626.6 EFC43229.1 - 0.011 16.0 0.3 9.1 6.5 0.0 2.9 2 1 1 3 3 3 0 Zc3h12a-like Ribonuclease NYN domain ApoB100_C PF12491.8 EFC43229.1 - 0.057 13.4 8.7 38 4.3 0.2 5.5 1 1 5 6 6 6 0 Apolipoprotein B100 C terminal SAS-6_N PF16531.5 EFC43229.1 - 0.36 11.4 5.6 0.78 10.4 5.1 2.3 1 1 0 1 1 1 0 Centriolar protein SAS N-terminal SOG2 PF10428.9 EFC43230.1 - 0.11 11.7 8.2 0.16 11.1 8.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Ndc1_Nup PF09531.10 EFC43230.1 - 1.8 7.1 6.0 2.6 6.6 6.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup EF-hand_8 PF13833.6 EFC43231.1 - 1.1e-06 28.4 0.0 2.4e-06 27.3 0.1 1.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 EFC43231.1 - 3e-05 24.4 0.0 4.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC43231.1 - 7.2e-05 22.4 0.2 0.00016 21.3 0.1 1.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EFC43231.1 - 0.00016 21.0 0.2 0.00032 20.0 0.2 1.4 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 EFC43231.1 - 0.027 14.0 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 EF hand DUF4497 PF14924.6 EFC43232.1 - 1.2e-09 38.5 0.1 4.9e-08 33.4 0.0 3.6 3 1 0 3 3 3 1 Protein of unknown function (DUF4497) SR-25 PF10500.9 EFC43232.1 - 0.0016 18.1 20.4 0.0016 18.1 20.4 3.4 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein FAM70 PF14967.6 EFC43233.1 - 7.4 5.9 7.3 8.8 5.7 7.3 1.1 1 0 0 1 1 1 0 FAM70 protein PhoPQ_related PF10142.9 EFC43234.1 - 8.7e-96 320.7 0.1 1.1e-95 320.4 0.1 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DUF3494 PF11999.8 EFC43234.1 - 4.5e-10 39.5 7.3 8.4e-10 38.6 7.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3494) Ribosomal_L10 PF00466.20 EFC43235.1 - 4.4e-12 46.0 0.2 6.8e-12 45.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFC43235.1 - 1.3e-08 34.7 0.1 4.7e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 EFC43236.1 - 2.5e-14 53.2 0.4 9.5e-14 51.4 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L10 F-box-like PF12937.7 EFC43236.1 - 0.014 15.3 0.1 0.16 11.9 0.1 2.5 2 0 0 2 2 2 0 F-box-like RL10P_insert PF17777.1 EFC43236.1 - 0.066 13.2 0.1 0.75 9.8 0.0 2.4 1 1 1 2 2 2 0 Insertion domain in 60S ribosomal protein L10P 2OG-FeII_Oxy_3 PF13640.6 EFC43237.1 - 0.015 16.1 0.1 0.031 15.2 0.1 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Guanylate_cyc PF00211.20 EFC43238.1 - 1.5e-54 184.4 0.0 2.8e-54 183.5 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC43238.1 - 7.2e-08 32.4 0.1 2.2e-07 30.9 0.1 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EFC43238.1 - 7.2e-07 29.4 0.1 3.2e-06 27.3 0.1 2.3 1 0 0 1 1 1 1 PAS domain PAS_7 PF12860.7 EFC43238.1 - 0.045 13.9 0.0 0.31 11.2 0.0 2.6 1 1 0 1 1 1 0 PAS fold PAS_8 PF13188.7 EFC43238.1 - 0.047 13.7 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 EFC43238.1 - 0.17 12.1 0.0 0.34 11.2 0.0 1.5 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC43238.1 - 0.94 8.9 7.8 0.23 10.9 0.9 3.1 3 1 0 3 3 3 0 Heme NO binding associated WD40 PF00400.32 EFC43239.1 - 3.4e-10 40.4 0.6 7.9e-06 26.5 0.3 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat His_Phos_1 PF00300.22 EFC43239.1 - 2.1e-06 27.6 0.0 0.0033 17.2 0.0 2.4 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Ribosomal_L36e PF01158.18 EFC43240.1 - 1.4e-16 60.5 5.5 1.4e-16 60.5 5.5 1.4 1 1 0 1 1 1 1 Ribosomal protein L36e Ependymin PF00811.18 EFC43241.1 - 0.0066 16.7 1.0 0.27 11.5 1.0 2.2 1 1 0 1 1 1 1 Ependymin Patatin PF01734.22 EFC43243.1 - 6.9e-18 65.6 0.0 1.2e-17 64.8 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3979 PF13141.6 EFC43243.1 - 0.026 14.8 0.0 0.13 12.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3979) Cu-binding_MopE PF11617.8 EFC43244.1 - 0.0026 17.9 6.3 0.0026 17.9 6.3 2.1 2 0 0 2 2 2 1 Putative metal-binding motif Lipase_GDSL PF00657.22 EFC43244.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase SapB_2 PF03489.17 EFC43244.1 - 0.033 14.3 0.3 0.13 12.4 0.3 2.1 1 0 0 1 1 1 0 Saposin-like type B, region 2 OB_NTP_bind PF07717.16 EFC43245.1 - 6e-10 39.4 0.3 2.4e-09 37.4 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RRM_1 PF00076.22 EFC43245.1 - 6.6e-09 35.5 0.3 0.0062 16.3 0.0 4.0 4 0 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) IBR PF01485.21 EFC43245.1 - 2.3e-07 30.9 11.2 2.3e-07 30.9 11.2 3.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 EFC43245.1 - 2e-05 24.5 8.3 2e-05 24.5 8.3 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC43245.1 - 0.00056 19.7 11.6 0.00056 19.7 11.6 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC43245.1 - 0.0011 18.8 14.2 0.0011 18.8 14.2 3.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-Di19 PF05605.12 EFC43245.1 - 0.023 15.0 0.5 0.023 15.0 0.5 3.4 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding KH_1 PF00013.29 EFC43245.1 - 0.094 12.5 11.0 0.2 11.5 0.8 3.8 4 0 0 4 4 4 0 KH domain zf-C3HC4_3 PF13920.6 EFC43245.1 - 0.33 10.9 33.4 0.032 14.1 9.4 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC43245.1 - 0.36 11.2 32.0 0.13 12.6 13.5 3.2 2 1 0 2 2 2 0 Ring finger domain zf-MIZ PF02891.20 EFC43245.1 - 1.4 8.7 16.9 0.036 13.8 9.0 2.4 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger RasGEF PF00617.19 EFC43246.1 - 3.8e-61 206.4 2.9 3.8e-61 206.4 2.9 2.2 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFC43246.1 - 8.8e-27 93.4 5.2 1.8e-26 92.4 1.5 3.2 2 0 0 2 2 2 1 RasGEF N-terminal motif Atrophin-1 PF03154.15 EFC43246.1 - 0.031 12.6 13.0 0.042 12.1 13.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family RasGEF PF00617.19 EFC43247.1 - 4.4e-61 206.1 2.9 4.4e-61 206.1 2.9 2.5 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFC43247.1 - 1.3e-26 92.9 5.5 2e-26 92.2 1.5 3.3 2 0 0 2 2 2 1 RasGEF N-terminal motif RRF_GI PF12614.8 EFC43247.1 - 0.2 11.8 4.1 0.63 10.2 3.7 2.1 1 1 0 1 1 1 0 Ribosome recycling factor ZapB PF06005.12 EFC43247.1 - 2.9 8.4 21.8 0.096 13.1 12.0 3.5 3 1 1 4 4 4 0 Cell division protein ZapB PhoLip_ATPase_C PF16212.5 EFC43248.1 - 2.7e-63 214.0 22.8 2.7e-63 214.0 22.8 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EFC43248.1 - 1.3e-11 45.2 0.0 0.035 14.4 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFC43248.1 - 1.6e-09 37.6 2.2 5.1e-09 35.9 0.0 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFC43248.1 - 3.8e-07 30.1 0.0 1.3e-05 25.2 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC43248.1 - 0.0048 16.7 0.1 0.016 15.0 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Radial_spoke PF04712.12 EFC43249.1 - 4.6e-112 375.5 9.9 4.2e-78 263.5 0.7 2.3 1 1 1 2 2 2 2 Radial spokehead-like protein EF-hand_1 PF00036.32 EFC43250.1 - 2.2e-10 39.3 0.5 0.0001 21.6 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFC43250.1 - 2.3e-10 39.5 0.6 0.00026 20.7 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 EFC43250.1 - 1.8e-08 34.7 1.8 1.3e-07 31.9 1.8 2.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EFC43250.1 - 1e-05 25.2 1.2 0.071 13.0 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC43250.1 - 0.0017 17.7 0.2 0.25 10.9 0.0 2.4 2 0 0 2 2 2 2 EF hand MCR PF18509.1 EFC43252.1 - 0.088 12.4 0.1 0.088 12.4 0.1 2.3 2 0 0 2 2 2 0 Magnetochrome domain DUF5082 PF16888.5 EFC43254.1 - 0.00072 19.8 10.0 0.031 14.5 3.3 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF5082) Cast PF10174.9 EFC43254.1 - 0.00081 17.8 14.0 0.0032 15.8 14.0 1.8 1 1 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Spc7 PF08317.11 EFC43254.1 - 0.0013 17.7 14.6 0.0015 17.5 14.6 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein KxDL PF10241.9 EFC43254.1 - 0.0026 18.0 10.4 0.051 13.9 3.7 2.3 1 1 1 2 2 2 2 Uncharacterized conserved protein APG6_N PF17675.1 EFC43254.1 - 0.0032 18.0 15.6 0.06 13.9 4.7 2.0 1 1 1 2 2 2 2 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 EFC43254.1 - 0.004 17.2 16.9 0.031 14.3 10.6 2.6 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Syntaxin-6_N PF09177.11 EFC43254.1 - 0.0079 16.7 15.1 0.073 13.6 15.1 2.1 1 1 0 1 1 1 1 Syntaxin 6, N-terminal V-SNARE_C PF12352.8 EFC43254.1 - 0.019 15.2 6.1 0.22 11.8 1.8 2.7 1 1 2 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Golgin_A5 PF09787.9 EFC43254.1 - 0.023 14.2 11.2 0.025 14.0 11.2 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF5339 PF17274.2 EFC43254.1 - 0.024 15.5 4.3 0.28 12.1 0.7 2.1 1 1 0 2 2 2 0 Family of unknown function (DUF5339) COG2 PF06148.11 EFC43254.1 - 0.029 14.5 4.7 0.34 11.0 4.7 2.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 WEMBL PF05701.11 EFC43254.1 - 0.032 12.9 10.2 0.034 12.8 10.2 1.0 1 0 0 1 1 1 0 Weak chloroplast movement under blue light WXG100 PF06013.12 EFC43254.1 - 0.033 14.4 4.8 7.4 6.9 0.2 3.0 1 1 0 2 2 2 0 Proteins of 100 residues with WXG HMMR_N PF15905.5 EFC43254.1 - 0.047 13.2 17.5 0.05 13.1 17.5 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF745 PF05335.13 EFC43254.1 - 0.059 13.1 8.8 0.062 13.0 8.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF4200 PF13863.6 EFC43254.1 - 0.07 13.5 8.0 0.66 10.4 8.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) HIP1_clath_bdg PF16515.5 EFC43254.1 - 0.079 13.6 14.0 0.39 11.4 7.3 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Nup54 PF13874.6 EFC43254.1 - 0.091 12.9 6.7 0.12 12.5 6.7 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF3584 PF12128.8 EFC43254.1 - 0.1 10.1 10.4 0.11 9.9 10.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2203 PF09969.9 EFC43254.1 - 0.1 13.3 3.2 0.82 10.4 3.2 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF3552 PF12072.8 EFC43254.1 - 0.12 11.8 11.3 0.2 11.1 11.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) ARA70 PF12489.8 EFC43254.1 - 0.12 12.6 8.0 0.17 12.1 8.0 1.4 1 1 0 1 1 1 0 Nuclear coactivator DUF1664 PF07889.12 EFC43254.1 - 0.13 12.3 9.5 0.82 9.7 9.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 EFC43254.1 - 0.14 11.5 8.9 0.24 10.7 8.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Bul1_N PF04425.12 EFC43254.1 - 0.15 10.8 8.2 0.17 10.6 8.2 1.0 1 0 0 1 1 1 0 Bul1 N terminus Prefoldin_2 PF01920.20 EFC43254.1 - 0.18 11.8 14.8 0.8 9.7 4.0 2.6 1 1 1 2 2 2 0 Prefoldin subunit Prominin PF05478.11 EFC43254.1 - 0.2 9.6 9.4 0.22 9.4 9.4 1.0 1 0 0 1 1 1 0 Prominin Sec20 PF03908.13 EFC43254.1 - 0.24 11.4 11.8 0.86 9.6 2.3 2.1 1 1 1 2 2 2 0 Sec20 bZIP_1 PF00170.21 EFC43254.1 - 0.29 11.3 15.6 0.26 11.4 2.1 3.0 1 1 3 4 4 4 0 bZIP transcription factor APG17 PF04108.12 EFC43254.1 - 0.3 10.1 12.5 0.38 9.8 12.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 DASH_Dam1 PF08653.10 EFC43254.1 - 0.32 10.8 4.6 0.67 9.8 0.7 2.5 1 1 2 3 3 3 0 DASH complex subunit Dam1 Exonuc_VII_L PF02601.15 EFC43254.1 - 0.36 10.4 8.0 0.38 10.3 8.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit GLE1 PF07817.13 EFC43254.1 - 0.36 10.0 4.2 0.35 10.0 3.5 1.3 1 1 0 1 1 1 0 GLE1-like protein ZapB PF06005.12 EFC43254.1 - 0.39 11.2 16.1 0.36 11.3 8.8 2.5 1 1 1 2 2 2 0 Cell division protein ZapB IFT57 PF10498.9 EFC43254.1 - 0.39 9.6 14.9 0.59 9.0 14.9 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Cauli_AT PF03233.13 EFC43254.1 - 0.47 10.4 6.7 0.66 9.9 6.7 1.3 1 1 0 1 1 1 0 Aphid transmission protein TMPIT PF07851.13 EFC43254.1 - 0.52 9.5 9.8 0.54 9.4 9.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein DLP_helical PF18709.1 EFC43254.1 - 0.68 9.1 7.6 0.22 10.7 2.2 2.0 1 1 1 2 2 2 0 Dynamin-like helical domain Laminin_II PF06009.12 EFC43254.1 - 0.84 9.7 12.0 2.5 8.1 4.1 2.1 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.8 EFC43254.1 - 0.99 9.6 14.6 0.69 10.2 10.7 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ADIP PF11559.8 EFC43254.1 - 1 9.4 19.4 3.3 7.8 8.2 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding UPF0449 PF15136.6 EFC43254.1 - 1.1 9.8 13.5 8.7 6.9 6.0 2.9 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 OEP PF02321.18 EFC43254.1 - 1.1 9.0 6.1 2.4 7.9 6.1 1.6 1 1 0 1 1 1 0 Outer membrane efflux protein KELK PF15796.5 EFC43254.1 - 1.1 9.7 9.6 0.82 10.2 1.3 2.4 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase V_ATPase_I PF01496.19 EFC43254.1 - 1.2 7.0 10.5 1.2 7.0 10.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fez1 PF06818.15 EFC43254.1 - 1.3 9.4 11.9 2.7 8.4 11.9 1.5 1 1 0 1 1 1 0 Fez1 Prp19 PF08606.11 EFC43254.1 - 1.7 8.7 7.4 1 9.4 0.9 2.7 1 1 1 3 3 3 0 Prp19/Pso4-like Mce4_CUP1 PF11887.8 EFC43254.1 - 1.8 8.0 7.6 2 7.8 7.6 1.1 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative ApoO PF09769.9 EFC43254.1 - 1.9 8.4 6.2 20 5.1 6.2 2.1 1 1 0 1 1 1 0 Apolipoprotein O Jnk-SapK_ap_N PF09744.9 EFC43254.1 - 2.4 8.4 13.7 5.2 7.3 13.7 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DivIC PF04977.15 EFC43254.1 - 2.5 7.9 10.1 4.6 7.1 1.2 2.7 1 1 2 3 3 3 0 Septum formation initiator TMF_DNA_bd PF12329.8 EFC43254.1 - 2.8 8.0 20.0 5.5 7.1 9.6 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Pedibin PF08182.11 EFC43254.1 - 3 7.7 6.5 9.4 6.1 0.1 3.0 3 0 0 3 3 3 0 Pedibin/Hym-346 family Vps54_N PF10475.9 EFC43254.1 - 3.2 6.9 12.3 1.7 7.9 4.4 1.9 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex DASH_Duo1 PF08651.10 EFC43254.1 - 3.4 7.5 13.7 7.5 6.4 2.7 2.5 1 1 2 3 3 3 0 DASH complex subunit Duo1 CENP-H PF05837.12 EFC43254.1 - 3.6 8.0 12.5 6.8 7.1 12.5 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) JIP_LZII PF16471.5 EFC43254.1 - 6 7.1 17.6 10 6.4 4.4 2.8 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II DUF1968 PF09291.10 EFC43255.1 - 0.057 13.5 0.6 0.12 12.5 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1968) Mak16 PF04874.14 EFC43255.1 - 0.23 12.1 5.0 0.46 11.1 5.0 1.6 1 1 0 1 1 1 0 Mak16 protein C-terminal region Acyltransferase PF01553.21 EFC43256.1 - 0.00041 20.0 0.0 0.00054 19.6 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 EFC43257.1 - 4.6e-16 58.7 1.5 1.5e-15 57.0 0.8 2.0 2 0 0 2 2 2 1 Acyltransferase C-terminus Acyltransferase PF01553.21 EFC43257.1 - 0.12 12.0 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Acyltransferase PP-binding PF00550.25 EFC43258.1 - 8.7e-12 45.2 0.0 1.2e-11 44.8 0.0 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 EFC43258.1 - 4.1e-05 23.7 0.1 5e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Acyl-carrier HalOD1 PF18545.1 EFC43258.1 - 0.0072 16.6 0.1 0.011 16.0 0.1 1.3 1 0 0 1 1 1 1 Halobacterial output domain 1 NUDIX PF00293.28 EFC43259.1 - 6.7e-10 39.1 0.1 1.1e-09 38.4 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain CCB2_CCB4 PF11152.8 EFC43261.1 - 0.052 12.9 0.1 0.8 9.0 0.0 2.4 2 1 0 2 2 2 0 Cofactor assembly of complex C subunit B, CCB2/CCB4 ubiquitin PF00240.23 EFC43262.1 - 1.4e-62 207.3 6.7 3.7e-31 106.7 0.9 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC43262.1 - 7.6e-31 105.8 8.1 5e-16 58.3 0.9 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC43262.1 - 4.4e-09 36.7 4.0 0.0017 18.7 0.4 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC43262.1 - 2.1e-08 33.9 0.4 0.0031 17.4 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC43262.1 - 6.4e-08 32.9 2.2 0.0028 18.0 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC43262.1 - 1.4e-07 31.6 0.3 0.0027 17.8 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC43262.1 - 2.5e-06 28.0 0.1 0.0094 16.5 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC43262.1 - 7.9e-05 22.6 7.1 3.9 7.6 0.2 4.0 2 2 2 4 4 4 2 Ubiquitin-like domain Raf1_HTH PF18579.1 EFC43262.1 - 0.024 14.3 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain TUG-UBL1 PF11470.8 EFC43262.1 - 0.026 14.7 0.0 8 6.8 0.0 2.1 2 0 0 2 2 2 0 TUG ubiquitin-like domain TnpV PF14198.6 EFC43262.1 - 0.031 14.2 0.5 1.2 9.1 0.1 2.1 2 0 0 2 2 2 0 Transposon-encoded protein TnpV DUF3861 PF12977.7 EFC43262.1 - 0.059 13.5 0.6 1.6 8.9 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) RBD PF02196.15 EFC43262.1 - 0.076 13.1 0.0 3.8 7.7 0.0 2.4 2 0 0 2 2 2 0 Raf-like Ras-binding domain PI3K_p85B PF02192.16 EFC43262.1 - 0.095 12.5 0.4 7.9 6.3 0.1 2.3 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain ProRS-C_2 PF09181.10 EFC43262.1 - 0.1 12.7 1.6 4.2 7.6 0.3 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Coagulin PF02035.15 EFC43262.1 - 0.11 12.4 0.3 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Coagulin DUF969 PF06149.12 EFC43262.1 - 0.12 11.8 0.0 6.2 6.2 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF969) Sel1 PF08238.12 EFC43263.1 - 2.5e-38 129.7 24.3 5.7e-09 36.4 0.1 6.5 6 1 0 6 6 6 6 Sel1 repeat TPR_12 PF13424.6 EFC43263.1 - 0.00017 21.8 5.7 0.067 13.5 0.9 4.4 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC43263.1 - 0.00068 19.8 5.1 0.93 10.0 0.5 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC43263.1 - 0.0027 18.3 0.1 10 6.9 0.0 3.6 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC43263.1 - 0.0064 17.2 0.0 0.19 12.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 EFC43263.1 - 0.0087 16.1 3.9 0.55 10.3 0.2 3.1 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 EFC43263.1 - 0.022 14.9 8.3 0.13 12.5 1.9 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFC43263.1 - 0.036 13.8 4.0 1 9.1 1.8 3.0 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.17 EFC43263.1 - 0.036 14.2 0.3 0.036 14.2 0.3 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43263.1 - 0.052 13.8 8.3 0.13 12.6 0.2 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EFC43263.1 - 0.062 13.6 1.8 0.23 11.8 0.5 2.5 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 TPR_1 PF00515.28 EFC43263.1 - 0.065 13.1 16.1 0.07 13.0 0.2 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3978 PF13123.6 EFC43263.1 - 0.069 12.9 0.2 0.18 11.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3978) TPR_20 PF14561.6 EFC43263.1 - 0.16 12.4 0.1 0.72 10.2 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat HEPN_Apea PF18739.1 EFC43263.1 - 0.48 10.9 5.6 33 5.0 0.1 4.0 2 1 0 3 3 3 0 Apea-like HEPN PTase_Orf2 PF11468.8 EFC43264.1 - 0.00075 19.0 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Aromatic prenyltransferase Orf2 Ank_2 PF12796.7 EFC43266.1 - 0.00017 22.1 0.0 0.00048 20.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC43266.1 - 0.15 12.6 0.0 3.2 8.4 0.0 2.8 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC43266.1 - 0.17 12.3 0.0 1.4 9.3 0.0 2.3 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Cyclin_C PF02984.19 EFC43267.1 - 2e-06 27.9 0.1 2e-06 27.9 0.1 2.7 2 2 1 3 3 3 1 Cyclin, C-terminal domain NTP_transf_9 PF04248.12 EFC43267.1 - 0.15 12.0 0.2 0.33 10.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF427) Pkinase PF00069.25 EFC43268.1 - 7.4e-37 127.1 3.9 1.3e-29 103.4 1.6 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43268.1 - 1.9e-26 92.9 1.7 1.1e-25 90.4 0.7 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43268.1 - 0.012 14.9 0.3 0.023 14.0 0.3 1.4 1 0 0 1 1 1 0 Kinase-like ENTH PF01417.20 EFC43268.1 - 0.03 14.4 0.0 0.14 12.2 0.0 2.3 1 0 0 1 1 1 0 ENTH domain Xpo1 PF08389.12 EFC43268.1 - 0.07 13.2 1.2 0.39 10.8 0.0 2.7 3 0 0 3 3 3 0 Exportin 1-like protein SlyX PF04102.12 EFC43268.1 - 9 7.0 8.1 2.9 8.6 4.6 2.0 2 0 0 2 2 2 0 SlyX LRR_6 PF13516.6 EFC43269.1 - 1e-18 65.7 31.8 1e-05 25.2 0.1 11.3 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.7 EFC43269.1 - 3.5e-15 55.9 48.1 1.4e-05 25.3 0.6 9.7 5 1 7 12 12 12 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43269.1 - 0.00037 20.2 0.9 0.00037 20.2 0.9 8.3 6 4 4 10 10 10 4 Leucine rich repeat LRR_1 PF00560.33 EFC43269.1 - 0.034 14.7 23.9 7 7.6 0.2 9.6 10 0 0 10 10 10 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC43269.1 - 0.036 13.6 22.8 0.079 12.5 0.3 4.7 2 1 4 6 6 6 0 Leucine-rich repeat DUF1319 PF07028.11 EFC43269.1 - 0.071 13.3 2.0 12 6.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1319) FAM176 PF14851.6 EFC43270.1 - 0.064 12.9 2.0 0.074 12.7 0.3 1.9 2 0 0 2 2 2 0 FAM176 family EphA2_TM PF14575.6 EFC43270.1 - 0.38 11.7 2.2 0.72 10.8 0.5 2.4 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain ubiquitin PF00240.23 EFC43271.1 - 3.1e-19 68.5 0.1 3.4e-19 68.3 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC43271.1 - 2.7e-07 30.3 0.1 2.9e-07 30.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC43271.1 - 0.0073 16.2 0.1 0.0085 16.0 0.1 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain PolyA_pol PF01743.20 EFC43272.1 - 0.0037 17.7 1.2 0.0062 17.0 1.2 1.6 1 1 0 1 1 1 1 Poly A polymerase head domain SLATT_4 PF18186.1 EFC43272.1 - 0.11 12.2 0.2 0.17 11.5 0.2 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 adh_short PF00106.25 EFC43274.1 - 2.2e-51 174.1 0.8 2.7e-51 173.8 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43274.1 - 7.2e-37 127.2 0.3 8.9e-37 126.9 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43274.1 - 9.4e-13 48.5 0.8 1.3e-12 48.0 0.8 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC43274.1 - 0.00035 20.1 0.8 0.0037 16.8 0.8 2.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ammonium_transp PF00909.21 EFC43275.1 - 4.9e-109 364.6 33.2 5.8e-109 364.4 33.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Ammonium_transp PF00909.21 EFC43276.1 - 1e-107 360.3 34.0 1.2e-107 360.1 34.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF1196 PF06709.11 EFC43276.1 - 0.066 13.4 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1196) RRM_1 PF00076.22 EFC43277.1 - 5.1e-33 112.7 0.3 4.9e-16 58.3 0.1 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 EFC43277.1 - 5.8e-05 23.4 0.1 0.28 11.4 0.0 2.8 2 1 1 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter BRAP2 PF07576.12 EFC43277.1 - 0.0051 17.0 0.0 0.74 10.1 0.0 2.1 2 0 0 2 2 2 1 BRCA1-associated protein 2 RRM_7 PF16367.5 EFC43277.1 - 0.011 15.8 0.0 0.043 13.9 0.0 2.1 2 2 0 2 2 2 0 RNA recognition motif RRM_occluded PF16842.5 EFC43277.1 - 0.016 15.0 0.0 0.85 9.5 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_5 PF13893.6 EFC43277.1 - 0.02 14.5 0.0 0.57 9.8 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFC43277.1 - 0.023 14.7 0.0 9.2 6.4 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif UQ_con PF00179.26 EFC43278.1 - 2.8e-46 156.6 0.1 3.3e-46 156.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC43278.1 - 0.0071 16.6 0.5 0.0091 16.3 0.5 1.4 1 1 0 1 1 1 1 RWD domain Zn_clus PF00172.18 EFC43279.1 - 0.00012 22.1 13.5 0.00027 21.0 13.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 EFC43279.1 - 0.0032 17.2 2.6 0.0084 15.9 2.6 1.8 1 0 0 1 1 1 1 AT hook motif LRR_8 PF13855.6 EFC43280.1 - 1.7e-08 34.1 9.6 0.00065 19.4 1.5 4.9 4 2 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 EFC43280.1 - 1.8e-06 28.1 22.6 0.014 15.8 1.8 6.5 4 2 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC43280.1 - 0.0011 18.8 12.1 0.75 10.0 0.2 5.9 6 0 0 6 6 6 2 Leucine Rich repeat LRR_5 PF13306.6 EFC43280.1 - 0.0048 16.9 18.7 0.065 13.2 2.1 3.1 2 1 1 3 3 3 3 BspA type Leucine rich repeat region (6 copies) F-box PF00646.33 EFC43280.1 - 0.034 14.0 1.1 0.034 14.0 1.1 3.6 4 0 0 4 4 4 0 F-box domain LRR_1 PF00560.33 EFC43280.1 - 0.13 12.9 21.1 5.4 8.0 1.8 8.6 6 4 1 7 7 7 0 Leucine Rich Repeat SNF2_N PF00176.23 EFC43281.1 - 6e-25 87.7 0.1 8.4e-25 87.2 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC43281.1 - 3.3e-10 40.3 0.0 1.3e-09 38.3 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC43281.1 - 4.1e-05 23.6 0.1 0.00028 20.9 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFC43281.1 - 0.03 13.2 0.0 0.046 12.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 Musclin PF11037.8 EFC43281.1 - 0.091 12.7 0.4 0.17 11.8 0.4 1.4 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle BTB PF00651.31 EFC43282.1 - 4.9e-14 52.5 3.2 7.4e-14 51.9 0.5 2.6 2 1 1 3 3 3 1 BTB/POZ domain BACK PF07707.15 EFC43282.1 - 1.5e-09 37.9 0.2 1.5e-09 37.9 0.2 3.3 5 0 0 5 5 5 1 BTB And C-terminal Kelch DUF3342 PF11822.8 EFC43282.1 - 0.0006 20.0 0.7 0.061 13.5 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) BTB_2 PF02214.22 EFC43282.1 - 0.0039 17.5 0.2 0.46 10.9 0.0 3.3 3 0 0 3 3 3 1 BTB/POZ domain BTB_3 PF16017.5 EFC43282.1 - 0.056 13.6 0.2 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 BTB/POZ domain JAB PF01398.21 EFC43283.1 - 9.8e-13 48.1 0.5 3.2e-12 46.5 0.0 2.2 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EFC43283.1 - 1.8e-09 37.4 0.0 5.1e-09 35.9 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain DUF1819 PF08849.11 EFC43283.1 - 0.0041 16.9 1.3 0.0088 15.9 1.3 1.6 1 0 0 1 1 1 1 Putative inner membrane protein (DUF1819) Crystall_3 PF08964.10 EFC43283.1 - 0.037 14.2 0.2 0.19 11.9 0.1 2.3 2 0 0 2 2 2 0 Beta/Gamma crystallin ATP-synt_DE PF00401.20 EFC43284.1 - 0.041 14.2 3.2 1.1 9.5 0.4 2.8 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF2757 PF10955.8 EFC43284.1 - 0.94 9.8 3.3 0.68 10.2 0.3 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) POPLD PF08170.12 EFC43284.1 - 1.3 9.4 4.2 28 5.1 0.0 3.4 3 1 0 3 3 3 0 POPLD (NUC188) domain G-alpha PF00503.20 EFC43286.1 - 6.4e-63 213.0 23.4 3.6e-62 210.6 23.4 1.9 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC43286.1 - 1.1e-06 28.2 0.2 6.4e-05 22.5 0.1 2.5 2 0 0 2 2 2 1 ADP-ribosylation factor family KAP_NTPase PF07693.14 EFC43286.1 - 0.00077 18.8 0.1 0.0045 16.3 0.0 2.0 1 1 1 2 2 2 1 KAP family P-loop domain SRP54 PF00448.22 EFC43286.1 - 0.0012 18.6 0.0 0.0027 17.4 0.0 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 EFC43286.1 - 0.0068 16.8 0.8 0.027 14.8 0.8 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFC43286.1 - 0.008 16.7 0.9 0.094 13.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATP_bind_1 PF03029.17 EFC43286.1 - 0.019 14.8 1.2 2.4 7.9 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 EFC43286.1 - 0.021 14.6 0.3 0.054 13.2 0.3 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 EFC43286.1 - 0.089 12.3 0.1 0.22 11.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Thymidylate_kin PF02223.17 EFC43286.1 - 0.16 11.7 0.0 0.16 11.7 0.0 2.8 3 0 0 3 3 3 0 Thymidylate kinase adh_short_C2 PF13561.6 EFC43287.1 - 3.4e-52 177.3 0.1 3.9e-52 177.1 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC43287.1 - 3.1e-45 154.0 0.5 4e-45 153.7 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC43287.1 - 9.2e-11 42.0 2.0 5.6e-10 39.4 2.0 2.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC43287.1 - 8.7e-06 25.4 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFC43287.1 - 0.02 14.0 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFC43287.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding DUF2286 PF10051.9 EFC43287.1 - 0.1 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2286) PsbU PF06514.11 EFC43289.1 - 0.089 12.8 0.1 0.27 11.2 0.1 1.9 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) Pannexin_like PF12534.8 EFC43289.1 - 0.41 9.7 4.4 0.97 8.5 4.4 1.5 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Guanylate_cyc PF00211.20 EFC43290.1 - 1.4e-51 174.7 0.1 2.7e-51 173.8 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC43290.1 - 1.4e-15 57.4 0.1 5e-15 55.6 0.1 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC43290.1 - 0.00045 20.2 0.1 0.0035 17.3 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 EFC43290.1 - 0.0012 19.0 0.0 0.0024 18.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC43290.1 - 0.0091 15.5 0.2 0.022 14.2 0.2 1.6 1 0 0 1 1 1 1 Heme NO binding associated Caps_synth_GfcC PF06251.11 EFC43290.1 - 0.037 13.7 0.2 0.086 12.4 0.2 1.5 1 0 0 1 1 1 0 Capsule biosynthesis GfcC DUF444 PF04285.12 EFC43291.1 - 0.06 12.4 3.6 0.083 12.0 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF444) CDC45 PF02724.14 EFC43291.1 - 0.2 9.9 12.8 0.24 9.6 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 EFC43291.1 - 3.9 6.6 5.2 4.5 6.4 5.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ras PF00071.22 EFC43292.1 - 6.7e-53 178.6 0.3 7.7e-53 178.4 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43292.1 - 1.1e-24 86.9 0.0 1.6e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43292.1 - 1.4e-10 40.9 0.0 1.9e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC43292.1 - 0.0036 16.7 0.0 0.0064 15.9 0.0 1.4 1 1 0 2 2 2 1 Gtr1/RagA G protein conserved region Nmad2 PF18753.1 EFC43293.1 - 0.27 10.7 6.4 0.5 9.8 1.3 2.2 2 0 0 2 2 2 0 Nucleotide modification associated domain 2 Rad60-SLD PF11976.8 EFC43296.1 - 1.8e-24 85.4 8.6 6.6e-12 45.1 0.7 3.3 3 0 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 EFC43296.1 - 7.2e-16 57.7 5.6 1.5e-08 34.2 0.2 3.1 3 0 0 3 3 3 2 Ubiquitin family TBK1_ULD PF18396.1 EFC43296.1 - 1.9e-05 24.5 0.0 0.2 11.6 0.0 2.7 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain HPPK PF01288.20 EFC43296.1 - 3 8.4 5.1 18 5.9 0.2 3.1 3 0 0 3 3 3 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Glyco_hydro_15 PF00723.21 EFC43297.1 - 2.3e-37 128.8 0.0 3.1e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Dynamitin PF04912.14 EFC43298.1 - 1.1e-48 166.6 27.4 1.4e-48 166.2 27.4 1.0 1 0 0 1 1 1 1 Dynamitin Lactamase_B PF00753.27 EFC43299.1 - 1.2e-16 61.3 0.2 3.9e-16 59.7 0.1 1.7 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC43299.1 - 1.2e-05 24.9 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EFC43299.1 - 0.0016 17.9 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RdgC PF04381.12 EFC43299.1 - 0.058 12.6 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative exonuclease, RdgC adh_short PF00106.25 EFC43300.1 - 3.4e-55 186.5 1.3 4.1e-55 186.3 1.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43300.1 - 1e-37 130.0 0.2 1.2e-37 129.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43300.1 - 2.7e-14 53.5 1.5 8.9e-14 51.8 1.3 1.7 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 EFC43300.1 - 7.7e-06 25.5 0.4 1.7e-05 24.4 0.3 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC43300.1 - 0.00017 21.5 0.4 0.00029 20.8 0.4 1.6 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFC43300.1 - 0.0057 16.1 0.3 0.0083 15.6 0.3 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC43300.1 - 0.01 15.0 0.7 0.013 14.7 0.7 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EFC43300.1 - 0.013 15.6 0.4 0.034 14.2 0.1 1.9 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 EFC43300.1 - 0.037 13.4 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Phage_tail_APC PF16778.5 EFC43300.1 - 0.16 11.8 0.2 0.4 10.6 0.2 1.6 1 1 0 1 1 1 0 Phage tail assembly chaperone protein Guanylate_cyc PF00211.20 EFC43302.1 - 1.3e-51 174.9 0.8 2.5e-51 173.9 0.1 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC43302.1 - 2.2e-14 53.6 0.1 8.7e-14 51.6 0.0 2.2 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC43302.1 - 1.4e-05 25.0 0.0 3.3e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC43302.1 - 0.0037 17.5 0.0 0.0071 16.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC43302.1 - 0.0065 16.5 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 PAS domain DUF5078 PF16877.5 EFC43302.1 - 0.038 14.4 2.3 0.14 12.6 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5078) PAS_10 PF13596.6 EFC43302.1 - 0.061 13.9 0.0 0.2 12.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain DUF3855 PF12967.7 EFC43303.1 - 0.046 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3855) LRR_6 PF13516.6 EFC43304.1 - 2.1e-13 49.1 48.2 0.00016 21.5 1.6 10.5 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.7 EFC43304.1 - 1.6e-09 37.8 66.5 0.00071 19.9 1.4 7.3 3 2 5 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43304.1 - 1.7e-05 24.5 62.0 0.0013 18.5 8.2 8.3 2 2 3 6 6 6 5 Leucine rich repeat LRR_1 PF00560.33 EFC43304.1 - 0.029 14.9 47.2 4.7 8.1 3.0 9.5 9 2 0 9 9 9 0 Leucine Rich Repeat CooT PF10133.9 EFC43304.1 - 0.047 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT FTH PF01827.27 EFC43304.1 - 0.091 12.6 7.7 0.077 12.8 1.5 2.7 2 1 0 2 2 2 0 FTH domain JmjC PF02373.22 EFC43305.1 - 1.8e-38 131.5 0.3 2.3e-37 127.9 0.0 2.7 2 0 0 2 2 2 1 JmjC domain, hydroxylase JmjN PF02375.17 EFC43305.1 - 5.6e-15 55.0 2.6 1e-14 54.2 0.3 2.5 3 0 0 3 3 3 1 jmjN domain zf-C5HC2 PF02928.16 EFC43305.1 - 0.00062 20.1 6.2 0.0012 19.2 6.2 1.5 1 0 0 1 1 1 1 C5HC2 zinc finger DUF1517 PF07466.11 EFC43306.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) F-actin_cap_A PF01267.17 EFC43307.1 - 1.1e-80 270.9 0.3 1.3e-80 270.7 0.3 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit F_actin_cap_B PF01115.17 EFC43307.1 - 0.00015 21.5 0.4 0.00018 21.2 0.4 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Abhydrolase_1 PF00561.20 EFC43308.1 - 5.4e-12 45.9 0.7 1.8e-11 44.2 0.7 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 EFC43308.1 - 3.3e-07 30.6 0.0 4.9e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 EFC43308.1 - 1.2e-06 29.3 0.0 1.6e-06 28.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC43308.1 - 3.8e-05 23.1 0.2 0.00036 19.9 0.3 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Palm_thioest PF02089.15 EFC43308.1 - 0.00067 19.6 0.1 0.001 19.0 0.1 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 EFC43308.1 - 0.0033 17.2 0.1 0.14 11.9 0.1 2.2 1 1 0 1 1 1 1 PGAP1-like protein B3 PF02362.21 EFC43308.1 - 0.027 14.3 0.3 0.072 13.0 0.1 1.7 2 0 0 2 2 2 0 B3 DNA binding domain MATH PF00917.26 EFC43309.1 - 0.0074 16.4 0.1 2.3 8.4 0.0 2.9 2 0 0 2 2 2 2 MATH domain RCC1 PF00415.18 EFC43310.1 - 1.2e-38 131.5 5.5 1.2e-08 35.4 0.0 6.7 6 1 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43310.1 - 2.3e-18 65.5 22.4 2.3e-05 24.0 0.0 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC43311.1 - 2e-77 260.1 0.0 5.2e-77 258.8 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43311.1 - 2.9e-45 154.6 0.0 1e-44 152.8 0.0 2.0 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 EFC43311.1 - 6.7e-14 52.0 0.0 1.8e-07 31.4 0.0 4.5 2 1 3 5 5 5 3 HEAT repeats HEAT PF02985.22 EFC43311.1 - 7.6e-14 50.6 0.8 0.2 12.0 0.0 6.0 5 0 0 5 5 5 4 HEAT repeat Arm PF00514.23 EFC43311.1 - 7.2e-13 48.1 1.9 5.6e-06 26.2 0.0 6.3 8 0 0 8 8 6 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC43311.1 - 1.4e-12 47.8 0.0 1.3e-05 25.6 0.0 4.9 3 1 0 3 3 3 2 HEAT-like repeat DUF3361 PF11841.8 EFC43311.1 - 1.4e-06 28.4 6.3 0.00025 21.0 0.0 4.8 6 0 0 6 6 6 1 Domain of unknown function (DUF3361) Kinase-like PF14531.6 EFC43311.1 - 6.9e-06 25.6 0.0 0.00012 21.5 0.0 2.3 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 EFC43311.1 - 0.00012 21.7 0.1 0.00031 20.4 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EFC43311.1 - 0.0013 17.6 0.0 0.0013 17.6 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 EFC43311.1 - 0.0019 17.8 0.2 0.017 14.8 0.0 2.5 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 EFC43311.1 - 0.0022 17.6 0.3 0.034 13.7 0.1 3.0 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EFC43311.1 - 0.0032 16.5 2.2 0.013 14.5 0.1 2.8 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFC43311.1 - 0.0045 16.9 0.0 0.0085 16.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family V-ATPase_H_C PF11698.8 EFC43311.1 - 0.014 15.5 12.3 0.21 11.7 0.2 4.9 4 1 4 8 8 7 0 V-ATPase subunit H Kdo PF06293.14 EFC43311.1 - 0.02 14.2 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIX1 PF08167.12 EFC43311.1 - 0.052 13.3 5.4 1.2 8.8 0.2 3.5 3 1 0 3 3 3 0 rRNA processing/ribosome biogenesis Atx10homo_assoc PF09759.9 EFC43311.1 - 0.14 12.2 4.6 1.1 9.4 0.2 3.3 3 0 0 3 3 2 0 Spinocerebellar ataxia type 10 protein domain CTNNBL PF08216.11 EFC43311.1 - 0.42 10.8 0.1 0.42 10.8 0.1 4.5 4 0 0 4 4 4 0 Catenin-beta-like, Arm-motif containing nuclear UNC45-central PF11701.8 EFC43311.1 - 0.65 9.9 6.5 1.4 8.8 0.5 3.8 3 2 0 3 3 3 0 Myosin-binding striated muscle assembly central Ras PF00071.22 EFC43312.1 - 2.5e-29 102.0 2.4 1.2e-11 44.5 0.0 4.0 3 1 0 3 3 3 3 Ras family Roc PF08477.13 EFC43312.1 - 5.6e-09 36.2 0.0 0.019 15.2 0.0 3.7 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Zip PF02535.22 EFC43312.1 - 0.39 9.9 6.1 0.58 9.3 6.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NST1 PF13945.6 EFC43312.1 - 1.5 8.9 16.1 3.9 7.5 16.1 1.7 1 0 0 1 1 1 0 Salt tolerance down-regulator SMYLE_N PF18615.1 EFC43312.1 - 2.3 7.7 8.9 0.32 10.5 4.9 1.6 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 EFC43312.1 - 9.6 4.8 9.3 15 4.3 9.3 1.2 1 0 0 1 1 1 0 Presenilin DUF455 PF04305.14 EFC43313.1 - 1.1e-53 182.4 0.0 1.4e-53 182.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) FAM183 PF14886.6 EFC43314.1 - 7e-38 129.7 6.2 1.1e-37 129.0 6.2 1.3 1 0 0 1 1 1 1 FAM183A and FAM183B related AKAP7_NLS PF10469.9 EFC43315.1 - 5e-48 163.7 1.9 5.7e-48 163.6 1.9 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 EFC43315.1 - 3.9e-07 30.1 0.0 5e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily Cu-oxidase_4 PF02578.15 EFC43315.1 - 0.082 12.5 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase Pkinase PF00069.25 EFC43316.1 - 5.5e-46 157.1 0.3 9.9e-46 156.2 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43316.1 - 1.5e-45 155.6 0.1 2.8e-45 154.6 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase DUF948 PF06103.11 EFC43316.1 - 0.04 14.2 0.4 2.7 8.3 0.0 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Chlam_PMP PF02415.17 EFC43316.1 - 0.044 14.3 8.2 4.1 8.1 0.1 4.1 3 0 0 3 3 3 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat NHL PF01436.21 EFC43317.1 - 2.5e-38 128.2 0.0 3.5e-07 29.9 0.0 10.9 11 0 0 11 11 11 8 NHL repeat SGL PF08450.12 EFC43317.1 - 2.6e-09 37.0 0.2 2.3e-05 24.1 0.0 3.9 4 2 0 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 EFC43317.1 - 0.00034 20.5 0.0 2.8 8.5 0.0 5.2 4 0 0 4 4 4 1 Two component regulator propeller Linker_histone PF00538.19 EFC43317.1 - 0.00096 19.5 9.0 1.5 9.2 0.0 6.9 9 0 0 9 9 9 1 linker histone H1 and H5 family Phytase-like PF13449.6 EFC43317.1 - 0.0064 16.5 0.1 16 5.4 0.0 4.5 4 1 2 6 6 6 1 Esterase-like activity of phytase SBBP PF06739.11 EFC43317.1 - 0.0066 16.4 13.9 3.6 7.7 0.1 6.3 6 0 0 6 6 6 1 Beta-propeller repeat CAT_RBD PF03123.15 EFC43317.1 - 0.98 9.4 3.0 12 5.9 0.0 3.8 4 0 0 4 4 4 0 CAT RNA binding domain N6_N4_Mtase PF01555.18 EFC43319.1 - 0.022 14.5 0.1 0.05 13.3 0.1 1.6 1 0 0 1 1 1 0 DNA methylase Alg14 PF08660.11 EFC43320.1 - 5e-61 205.7 0.0 5.9e-61 205.4 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like EAR PF07897.11 EFC43320.1 - 0.07 12.8 0.4 0.13 11.9 0.4 1.5 1 0 0 1 1 1 0 Ethylene-responsive binding factor-associated repression Lipoprotein_2 PF00921.17 EFC43321.1 - 7.8 6.0 6.1 0.77 9.3 1.4 1.7 2 0 0 2 2 2 0 Borrelia lipoprotein Motile_Sperm PF00635.26 EFC43322.1 - 2.8e-19 69.0 1.5 6.8e-19 67.7 0.2 2.3 2 0 0 2 2 2 1 MSP (Major sperm protein) domain DUF3258 PF11646.8 EFC43322.1 - 0.0079 16.3 5.0 0.051 13.7 1.4 2.7 2 0 0 2 2 2 1 Protein of unknown function DUF3258 PHA_gran_rgn PF09650.10 EFC43322.1 - 0.024 14.9 0.1 0.1 12.9 0.0 2.1 2 0 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) SRP_SPB PF02978.19 EFC43322.1 - 0.024 15.2 2.5 2.3 8.9 0.0 2.6 2 0 0 2 2 2 0 Signal peptide binding domain Tox-URI2 PF15653.6 EFC43322.1 - 0.053 13.8 2.2 0.12 12.7 0.7 2.4 1 1 1 2 2 2 0 URI fold toxin 2 Exonuc_VII_L PF02601.15 EFC43322.1 - 0.12 11.9 5.7 0.22 11.1 5.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pre-PUA PF17832.1 EFC43322.1 - 0.23 12.2 5.4 3.2 8.5 1.8 3.4 3 0 0 3 3 3 0 Pre-PUA-like domain DUF2009 PF09418.10 EFC43322.1 - 0.26 10.3 3.3 0.45 9.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) PARM PF17061.5 EFC43322.1 - 0.27 11.3 7.3 0.41 10.7 7.3 1.2 1 0 0 1 1 1 0 PARM Prominin PF05478.11 EFC43322.1 - 0.45 8.4 6.7 0.72 7.7 6.7 1.2 1 0 0 1 1 1 0 Prominin Atg14 PF10186.9 EFC43322.1 - 4.1 6.4 16.5 8.7 5.3 16.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 EFC43322.1 - 5.7 6.1 10.5 13 4.9 10.4 1.6 1 1 0 1 1 1 0 TMPIT-like protein DUF3450 PF11932.8 EFC43322.1 - 6.1 6.1 14.3 0.83 8.9 10.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) VWA PF00092.28 EFC43324.1 - 1.5e-15 57.9 0.3 2.3e-15 57.3 0.3 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC43324.1 - 7.8e-13 49.0 0.1 1.5e-12 48.1 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC43324.1 - 4.7e-06 26.6 0.0 7.3e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 EFC43324.1 - 0.01 16.0 0.0 0.017 15.2 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus VWA_CoxE PF05762.14 EFC43324.1 - 0.048 13.0 0.1 0.1 11.9 0.1 1.5 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein SR-25 PF10500.9 EFC43325.1 - 0.93 9.1 11.3 1.5 8.4 11.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UPF0183 PF03676.14 EFC43326.1 - 5.4e-125 417.7 4.8 6.2e-125 417.5 4.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0183) Sec8_exocyst PF04048.14 EFC43328.1 - 1.3e-14 54.3 5.2 1.8e-14 53.9 2.1 2.9 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain ABC_tran PF00005.27 EFC43329.1 - 1.3e-28 100.2 0.0 2.2e-28 99.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFC43329.1 - 1.6e-06 28.2 1.9 0.00034 20.5 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC43329.1 - 0.0014 18.1 0.3 0.05 13.0 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 EFC43329.1 - 0.0021 18.0 0.0 0.0063 16.4 0.0 1.6 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 EFC43329.1 - 0.0065 16.9 0.0 0.01 16.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain SbcCD_C PF13558.6 EFC43329.1 - 0.026 14.8 0.8 0.39 11.0 0.3 2.6 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFC43329.1 - 0.042 13.6 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC43329.1 - 0.078 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 EFC43329.1 - 0.088 12.5 0.1 0.15 11.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 EFC43329.1 - 0.12 12.8 1.1 0.26 11.7 0.1 2.0 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 EFC43329.1 - 0.22 11.4 0.5 0.77 9.7 0.1 2.0 2 0 0 2 2 2 0 NACHT domain RGS PF00615.19 EFC43330.1 - 1.9e-06 28.1 2.3 4.6e-06 26.9 2.3 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain STATa_Ig PF18214.1 EFC43330.1 - 0.0024 17.9 0.9 0.088 12.8 0.0 2.7 2 0 0 2 2 2 1 STATa Immunoglobulin-like domain Sec2p PF06428.11 EFC43330.1 - 0.054 13.5 0.2 2.9 7.9 0.0 3.2 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Anoctamin PF04547.12 EFC43330.1 - 0.12 11.1 4.0 0.19 10.5 4.0 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel RPT PF13446.6 EFC43330.1 - 0.36 10.8 2.9 0.85 9.6 0.5 2.6 3 0 0 3 3 3 0 A repeated domain in UCH-protein DUF4448 PF14610.6 EFC43330.1 - 2.1 8.1 6.7 0.25 11.1 1.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4448) Dyp_perox PF04261.12 EFC43331.1 - 4.4e-38 131.1 0.0 5.2e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Dyp-type peroxidase family RNA_pol_Rpb5_C PF01191.19 EFC43331.1 - 0.00026 20.8 0.1 1 9.3 0.0 3.0 2 1 1 3 3 3 2 RNA polymerase Rpb5, C-terminal domain AsnC_trans_reg PF01037.21 EFC43331.1 - 0.042 13.8 0.0 2.6 8.1 0.0 2.8 3 0 0 3 3 3 0 Lrp/AsnC ligand binding domain DUF588 PF04535.12 EFC43333.1 - 0.00098 18.9 0.1 0.0022 17.8 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF588) Exo_endo_phos PF03372.23 EFC43334.1 - 1.1e-12 48.0 0.0 1.4e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFC43334.1 - 0.00079 19.3 0.0 0.57 10.0 0.0 2.5 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase RGS PF00615.19 EFC43337.1 - 0.00099 19.4 4.7 0.00099 19.4 4.7 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain VAPB_antitox PF02697.14 EFC43337.1 - 0.22 12.3 4.4 0.31 11.9 0.9 2.4 2 0 0 2 2 2 0 Putative antitoxin EGF_2 PF07974.13 EFC43338.1 - 0.0027 18.1 23.8 0.0092 16.3 9.1 3.0 2 1 1 3 3 3 2 EGF-like domain EGF PF00008.27 EFC43338.1 - 0.67 10.3 17.4 0.8 10.1 0.4 3.2 2 1 1 3 3 3 0 EGF-like domain Cytomega_TRL10 PF06084.11 EFC43338.1 - 1.6 8.7 7.3 2.6 8.1 7.3 1.5 1 1 0 1 1 1 0 Cytomegalovirus TRL10 protein NHL PF01436.21 EFC43339.1 - 2.1e-33 112.6 13.6 5.1e-06 26.3 0.0 6.7 6 0 0 6 6 6 6 NHL repeat BTB PF00651.31 EFC43339.1 - 4.9e-11 42.8 0.2 1.7e-10 41.1 0.2 1.9 1 0 0 1 1 1 1 BTB/POZ domain Linker_histone PF00538.19 EFC43339.1 - 8.5e-05 22.8 4.1 51 4.3 0.0 6.1 6 0 0 6 6 6 0 linker histone H1 and H5 family SGL PF08450.12 EFC43339.1 - 0.00063 19.4 0.0 16 5.0 0.0 4.1 3 2 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region KdpD PF02702.17 EFC43339.1 - 0.0069 15.9 0.0 20 4.5 0.0 4.8 7 0 0 7 7 7 0 Osmosensitive K+ channel His kinase sensor domain DUF1236 PF06823.12 EFC43339.1 - 0.083 12.8 15.2 16 5.4 0.3 6.0 6 0 0 6 6 6 0 Protein of unknown function (DUF1236) TRL PF13146.6 EFC43339.1 - 0.19 12.0 14.5 2.7 8.3 0.0 5.4 6 0 0 6 6 6 0 TRL-like protein family PCMT PF01135.19 EFC43339.1 - 0.21 11.3 4.6 5.5 6.7 0.0 4.6 4 1 3 7 7 7 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Plasmo_rep PF12135.8 EFC43339.1 - 0.38 10.3 24.3 7.2 6.3 0.2 6.2 6 0 0 6 6 6 0 Plasmodium repeat family SNARE PF05739.19 EFC43340.1 - 3.3e-08 33.4 0.7 1.4e-07 31.3 0.7 2.1 1 1 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 EFC43340.1 - 1.4e-07 31.8 17.4 1.4e-07 31.8 17.4 3.4 1 1 3 4 4 4 1 Syntaxin-like protein Laminin_II PF06009.12 EFC43340.1 - 0.03 14.3 15.6 0.022 14.8 9.3 2.8 2 1 0 2 2 2 0 Laminin Domain II FTCD_C PF04961.12 EFC43340.1 - 0.31 10.8 5.3 0.19 11.5 1.7 2.2 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase IL5 PF02025.15 EFC43340.1 - 0.48 10.7 11.9 0.16 12.3 8.0 2.3 2 1 0 2 2 2 0 Interleukin 5 Lig_chan-Glu_bd PF10613.9 EFC43340.1 - 0.6 10.3 4.2 7.2 6.8 0.5 2.3 2 0 0 2 2 2 0 Ligated ion channel L-glutamate- and glycine-binding site MCPsignal PF00015.21 EFC43340.1 - 1.7 8.4 12.4 1.5 8.6 1.8 3.4 1 1 2 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain TRP PF06011.12 EFC43340.1 - 2 7.0 4.3 0.34 9.6 0.0 1.7 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel PIEZO PF15917.5 EFC43340.1 - 2.4 7.6 19.7 0.04 13.4 7.3 2.3 2 0 0 2 2 2 0 Piezo TMEM189_B_dmain PF10520.9 EFC43341.1 - 4.6e-69 232.0 3.5 7.2e-69 231.3 3.5 1.3 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain QueT PF06177.11 EFC43341.1 - 0.53 10.7 5.4 1.9 8.9 5.3 1.9 1 1 1 2 2 2 0 QueT transporter FA_hydroxylase PF04116.13 EFC43341.1 - 0.97 9.8 8.9 0.39 11.1 6.1 1.8 1 1 1 2 2 2 0 Fatty acid hydroxylase superfamily Sec23_trunk PF04811.15 EFC43343.1 - 1.7e-40 139.1 0.0 4.5e-40 137.7 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 EFC43343.1 - 7.7e-16 57.9 5.6 2.2e-15 56.4 5.6 1.9 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 EFC43343.1 - 2.2e-15 57.2 0.0 8.6e-15 55.3 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 EFC43343.1 - 4.7e-07 29.6 0.0 2.3e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Gelsolin repeat Sec23_helical PF04815.15 EFC43343.1 - 0.011 15.6 0.6 0.054 13.3 0.1 2.2 1 1 1 2 2 2 0 Sec23/Sec24 helical domain V-ATPase_H_N PF03224.14 EFC43343.1 - 0.11 11.7 0.0 0.28 10.4 0.0 1.6 1 0 0 1 1 1 0 V-ATPase subunit H cNMP_binding PF00027.29 EFC43344.1 - 7.9e-18 64.3 0.0 1.4e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 EFC43344.1 - 9.7e-16 57.7 14.6 1.3e-15 57.3 14.6 1.2 1 0 0 1 1 1 1 Ion transport protein DUF296 PF03479.15 EFC43345.1 - 4.8e-22 78.4 0.1 8.1e-22 77.6 0.1 1.4 1 0 0 1 1 1 1 Plants and Prokaryotes Conserved (PCC) domain EF-hand_9 PF14658.6 EFC43345.1 - 0.1 12.9 0.0 0.34 11.3 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain ODV-E18 PF10717.9 EFC43345.1 - 0.13 12.2 0.8 0.36 10.7 0.8 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DAO PF01266.24 EFC43346.1 - 1.9e-05 24.4 0.0 0.063 12.8 0.0 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC43346.1 - 6.2e-05 22.4 0.3 0.012 14.9 0.3 3.1 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC43346.1 - 6.9e-05 22.2 0.2 0.0065 15.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC43346.1 - 0.00018 22.0 0.9 0.0045 17.5 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 EFC43346.1 - 0.00022 20.2 0.1 0.39 9.5 0.0 3.0 3 0 0 3 3 3 2 Tryptophan halogenase HI0933_like PF03486.14 EFC43346.1 - 0.04 12.6 0.1 0.092 11.4 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 EFC43346.1 - 0.095 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFC43346.1 - 0.1 11.8 0.3 0.24 10.6 0.1 1.6 2 0 0 2 2 2 0 Thi4 family DUF4728 PF15860.5 EFC43346.1 - 5.3 7.8 7.5 24 5.7 0.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4728) adh_short PF00106.25 EFC43347.1 - 2.4e-28 98.9 0.0 5.3e-25 88.0 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43347.1 - 1.7e-17 63.8 0.0 5.9e-17 62.0 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43347.1 - 0.0004 20.3 0.1 0.00059 19.8 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFC43347.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.3 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pro_isomerase PF00160.21 EFC43348.1 - 1.5e-53 181.3 0.0 1.7e-53 181.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Mob1_phocein PF03637.17 EFC43349.1 - 2.1e-70 236.1 0.1 2.4e-70 235.9 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family DUF4516 PF14990.6 EFC43349.1 - 0.072 12.8 0.1 10 6.0 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4516) ThiF PF00899.21 EFC43350.1 - 2.7e-57 193.9 0.2 4.4e-57 193.2 0.2 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 EFC43350.1 - 2.6e-13 50.4 0.0 5.6e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Sacchrp_dh_NADP PF03435.18 EFC43350.1 - 0.12 12.6 1.6 0.79 10.0 1.6 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF688 PF05097.12 EFC43351.1 - 0.0046 16.2 3.9 0.005 16.1 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF688) MMR_HSR1 PF01926.23 EFC43353.1 - 0.00015 21.9 0.0 0.0004 20.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FBA_1 PF07734.13 EFC43353.1 - 0.0046 16.9 0.1 0.01 15.8 0.1 1.5 1 0 0 1 1 1 1 F-box associated cobW PF02492.19 EFC43353.1 - 0.015 14.9 1.2 0.24 11.0 0.1 2.7 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 EFC43353.1 - 0.027 13.8 0.0 0.053 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family TsaE PF02367.17 EFC43353.1 - 0.061 13.3 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AIG1 PF04548.16 EFC43353.1 - 0.072 12.4 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Rep_fac_C PF08542.11 EFC43354.1 - 4.6e-20 71.8 0.0 1.1e-19 70.6 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EFC43354.1 - 1.7e-14 54.4 0.0 3.3e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFC43354.1 - 8.9e-12 45.1 0.2 3.3e-10 40.0 0.2 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_14 PF13173.6 EFC43354.1 - 7.1e-08 32.6 0.0 1.3e-07 31.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC43354.1 - 3.9e-07 30.6 0.1 9.6e-05 22.8 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 EFC43354.1 - 6.9e-06 25.6 0.0 3.6e-05 23.2 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 EFC43354.1 - 1.3e-05 25.5 3.5 0.099 12.9 0.1 3.0 2 1 1 3 3 3 2 AAA domain AAA_11 PF13086.6 EFC43354.1 - 7.1e-05 22.7 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFC43354.1 - 0.00014 21.9 0.1 0.00045 20.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 EFC43354.1 - 0.00014 22.2 0.2 0.00044 20.6 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFC43354.1 - 0.00039 20.2 0.0 0.0012 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFC43354.1 - 0.00046 20.0 0.0 0.0007 19.4 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EFC43354.1 - 0.00075 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 EFC43354.1 - 0.0012 19.1 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 EFC43354.1 - 0.0014 18.6 0.0 0.0036 17.3 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain DEAD PF00270.29 EFC43354.1 - 0.0015 18.4 0.5 0.077 12.8 0.0 2.5 2 1 1 3 3 2 1 DEAD/DEAH box helicase ATPase_2 PF01637.18 EFC43354.1 - 0.0019 18.2 0.0 0.0026 17.7 0.0 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EFC43354.1 - 0.0021 17.7 0.0 0.0039 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFC43354.1 - 0.0023 17.7 0.0 0.0068 16.2 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 EFC43354.1 - 0.0027 18.1 0.1 0.012 16.0 0.1 2.1 1 1 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 EFC43354.1 - 0.0029 17.6 0.4 0.3 11.0 0.1 2.4 1 1 1 2 2 2 1 NTPase AAA_assoc_2 PF16193.5 EFC43354.1 - 0.0039 17.5 0.5 0.018 15.4 0.0 2.5 2 2 0 2 2 2 1 AAA C-terminal domain AAA_3 PF07726.11 EFC43354.1 - 0.0079 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFC43354.1 - 0.0083 16.7 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 EFC43354.1 - 0.0084 15.6 0.1 1.5 8.2 0.0 2.6 3 0 0 3 3 2 1 PhoH-like protein AAA_24 PF13479.6 EFC43354.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFC43354.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 EFC43354.1 - 0.013 14.9 1.4 1.1 8.6 0.0 2.8 2 1 1 3 3 3 0 Bacterial TniB protein KTI12 PF08433.10 EFC43354.1 - 0.014 14.8 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ResIII PF04851.15 EFC43354.1 - 0.016 15.2 0.1 6.9 6.6 0.0 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.18 EFC43354.1 - 0.016 14.6 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF2247 PF10004.9 EFC43354.1 - 0.017 14.9 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2247) MipZ PF09140.11 EFC43354.1 - 0.024 13.9 0.0 0.039 13.2 0.0 1.2 1 0 0 1 1 1 0 ATPase MipZ IstB_IS21 PF01695.17 EFC43354.1 - 0.031 14.0 0.0 0.064 13.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 EFC43354.1 - 0.034 14.7 0.0 0.1 13.1 0.0 1.6 1 1 0 1 1 1 0 ABC transporter T2SSE PF00437.20 EFC43354.1 - 0.057 12.5 0.1 0.11 11.6 0.0 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein DUF2075 PF09848.9 EFC43354.1 - 0.069 12.4 1.8 1.5 8.0 1.8 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 EFC43354.1 - 0.074 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Longin PF13774.6 EFC43355.1 - 7e-19 67.7 0.2 1.2e-18 67.0 0.2 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 EFC43355.1 - 1.5e-18 66.4 0.4 2.7e-18 65.6 0.4 1.5 1 0 0 1 1 1 1 Synaptobrevin zf_PR_Knuckle PF18445.1 EFC43355.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 PR zinc knuckle motif Dala_Dala_lig_N PF01820.21 EFC43355.1 - 0.16 12.5 0.4 0.28 11.7 0.4 1.5 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus Myb_DNA-bind_5 PF13873.6 EFC43355.1 - 0.18 11.9 1.3 0.34 11.0 0.2 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Lipase_GDSL_2 PF13472.6 EFC43356.1 - 2.9e-19 70.1 0.0 3.3e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFC43356.1 - 7.8e-06 26.0 0.0 1.1e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 EFC43356.1 - 0.098 12.8 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Pkinase PF00069.25 EFC43358.1 - 1e-61 208.6 0.0 1.2e-61 208.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43358.1 - 1.3e-28 100.0 0.0 1.6e-28 99.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC43358.1 - 0.0026 17.7 0.1 0.0043 17.0 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC43358.1 - 0.026 13.9 0.2 0.068 12.5 0.1 1.7 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC43358.1 - 0.029 13.1 0.0 0.035 12.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFC43358.1 - 0.03 13.3 0.0 0.05 12.6 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Haspin_kinase PF12330.8 EFC43358.1 - 0.047 12.6 0.1 0.11 11.4 0.0 1.7 1 1 1 2 2 2 0 Haspin like kinase domain ATG16 PF08614.11 EFC43360.1 - 0.00079 19.7 22.4 0.00079 19.7 22.4 9.4 1 1 7 8 8 8 2 Autophagy protein 16 (ATG16) BST2 PF16716.5 EFC43360.1 - 0.00093 19.7 6.2 0.00093 19.7 6.2 14.5 6 5 7 14 14 14 1 Bone marrow stromal antigen 2 ADIP PF11559.8 EFC43360.1 - 0.0012 19.0 28.9 0.0012 19.0 28.9 11.2 4 2 7 11 11 11 3 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 EFC43360.1 - 0.006 16.6 19.3 0.006 16.6 19.3 11.5 4 2 8 12 12 12 5 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 EFC43360.1 - 0.013 15.5 4.7 0.013 15.5 4.7 17.2 7 6 6 15 15 15 0 TATA element modulatory factor 1 DNA binding Phage_tail_T PF06223.12 EFC43360.1 - 0.43 11.1 3.0 0.92 10.1 0.2 3.1 3 0 0 3 3 3 0 Minor tail protein T Bacillus_HBL PF05791.11 EFC43360.1 - 9.4 6.0 111.4 0.028 14.3 7.0 8.0 4 2 3 7 7 7 0 Bacillus haemolytic enterotoxin (HBL) Metallophos PF00149.28 EFC43361.1 - 0.0008 20.0 8.4 0.0095 16.4 5.2 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Hum_adeno_E3A PF05393.11 EFC43361.1 - 0.21 11.6 0.2 0.21 11.6 0.2 1.7 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein Syja_N PF02383.18 EFC43362.1 - 4.2e-79 266.2 0.4 5.9e-79 265.7 0.4 1.2 1 0 0 1 1 1 1 SacI homology domain Porphobil_deam PF01379.20 EFC43362.1 - 0.12 11.9 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain Ribosomal_L18A PF01775.17 EFC43363.1 - 7.7e-48 161.6 2.7 9.2e-48 161.3 2.7 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Sigma54_activ_2 PF14532.6 EFC43363.1 - 0.18 11.9 0.0 0.23 11.6 0.0 1.3 1 1 0 1 1 1 0 Sigma-54 interaction domain DUF3566 PF12089.8 EFC43364.1 - 0.14 12.5 5.1 0.41 11.0 0.0 3.5 4 0 0 4 4 4 0 Transmembrane domain of unknown function (DUF3566) Phosphoesterase PF04185.14 EFC43365.1 - 3.6e-30 105.3 2.5 5.8e-29 101.4 2.5 2.0 1 1 0 1 1 1 1 Phosphoesterase family DUF4788 PF16032.5 EFC43365.1 - 0.12 11.3 0.0 0.32 9.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4788) NHL PF01436.21 EFC43366.1 - 4e-34 114.9 22.7 2.6e-06 27.2 0.0 12.9 13 0 0 13 13 13 9 NHL repeat SGL PF08450.12 EFC43366.1 - 8.9e-13 48.4 9.0 0.18 11.4 0.5 7.6 4 3 3 7 7 7 5 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC43366.1 - 3.7e-07 30.4 38.8 0.0011 19.3 8.1 3.7 3 0 0 3 3 3 3 EGF-like domain Arylesterase PF01731.20 EFC43366.1 - 0.00057 20.0 12.3 6.1 7.1 0.0 7.7 8 1 1 9 9 9 1 Arylesterase EGF PF00008.27 EFC43366.1 - 0.00073 19.8 19.1 0.0015 18.8 1.6 4.1 3 0 0 3 3 3 2 EGF-like domain Str_synth PF03088.16 EFC43366.1 - 0.0037 17.3 7.2 0.83 9.8 0.0 6.7 8 1 0 8 8 8 1 Strictosidine synthase SBBP PF06739.11 EFC43366.1 - 2.9 8.0 24.3 1.1 9.3 0.2 6.8 8 0 0 8 8 8 0 Beta-propeller repeat RGS PF00615.19 EFC43369.1 - 2.1e-12 47.3 2.4 5.1e-12 46.1 2.4 1.7 1 1 0 1 1 1 1 Regulator of G protein signaling domain PX PF00787.24 EFC43369.1 - 1.4e-10 41.1 0.3 3.8e-10 39.7 0.3 1.7 1 0 0 1 1 1 1 PX domain DUF693 PF05113.13 EFC43369.1 - 0.0059 15.9 0.0 0.012 14.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF693) DUF1187 PF06688.11 EFC43369.1 - 0.026 14.9 0.2 0.087 13.2 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1187) AAA_23 PF13476.6 EFC43370.1 - 1.6e-15 58.2 0.3 1.7e-15 58.1 0.3 1.0 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EFC43370.1 - 1.5e-12 47.5 0.7 1.5e-12 47.4 0.7 1.0 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFC43370.1 - 1.6e-10 41.3 0.8 1.6e-10 41.3 0.8 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC43370.1 - 8.1e-06 25.5 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFC43370.1 - 0.0022 17.9 0.1 0.0022 17.8 0.1 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 EFC43370.1 - 0.0025 18.3 0.0 0.0028 18.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 EFC43370.1 - 0.003 17.5 0.1 0.0041 17.1 0.1 1.3 1 0 0 1 1 1 1 NACHT domain AAA_27 PF13514.6 EFC43370.1 - 0.01 15.5 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC43370.1 - 0.012 16.0 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFC43370.1 - 0.018 15.3 0.1 0.023 14.9 0.1 1.3 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFC43370.1 - 0.037 13.9 0.1 0.056 13.3 0.1 1.3 1 1 0 1 1 1 0 RsgA GTPase DUF2075 PF09848.9 EFC43370.1 - 0.05 12.8 0.2 0.056 12.7 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Orn_Arg_deC_N PF02784.16 EFC43371.1 - 1e-42 146.3 0.0 1.7e-42 145.5 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFC43371.1 - 1.9e-23 82.6 0.0 3.9e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AA_kinase PF00696.28 EFC43371.1 - 1.2e-12 48.0 0.0 3.4e-12 46.5 0.0 1.8 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 EFC43371.1 - 0.00017 21.3 0.0 0.00059 19.5 0.0 1.9 1 0 0 1 1 1 1 ACT domain GDPD PF03009.17 EFC43372.1 - 2.1e-21 76.9 0.0 4e-20 72.6 0.0 2.2 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family PI-PLC-X PF00388.19 EFC43372.1 - 0.022 14.3 0.0 0.047 13.3 0.0 1.5 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain SPACA9 PF15120.6 EFC43374.1 - 0.026 14.3 1.0 0.06 13.1 1.0 1.7 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 RGS PF00615.19 EFC43374.1 - 0.23 11.7 8.4 3.1 8.1 7.1 3.0 2 1 0 2 2 2 0 Regulator of G protein signaling domain DUF3619 PF12279.8 EFC43374.1 - 1.2 9.5 3.9 0.41 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Beta-lactamase PF00144.24 EFC43375.1 - 1.7e-36 126.2 0.0 1.5e-35 123.0 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase Aldedh PF00171.22 EFC43376.1 - 2.3e-151 504.4 0.0 2.6e-151 504.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ras PF00071.22 EFC43377.1 - 2.4e-43 147.6 0.1 1.6e-34 118.9 0.0 2.7 2 0 0 2 2 2 2 Ras family zf-C3HC4_3 PF13920.6 EFC43377.1 - 6.8e-15 54.7 10.2 6.8e-15 54.7 10.2 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Roc PF08477.13 EFC43377.1 - 4.9e-14 52.6 0.0 5e-08 33.2 0.0 2.9 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Prok-RING_4 PF14447.6 EFC43377.1 - 8.1e-09 35.2 8.7 8.1e-09 35.2 8.7 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Arf PF00025.21 EFC43377.1 - 1.8e-05 24.3 0.0 6.9e-05 22.4 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Sec23_BS PF08033.12 EFC43377.1 - 4.5e-05 24.1 1.0 0.00044 20.9 0.3 2.7 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-RING_5 PF14634.6 EFC43377.1 - 8.3e-05 22.5 9.2 8.3e-05 22.5 9.2 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFC43377.1 - 9.1e-05 22.7 9.8 9.1e-05 22.7 9.8 2.6 2 0 0 2 2 2 1 Ring finger domain RsgA_GTPase PF03193.16 EFC43377.1 - 0.00051 20.0 0.0 0.0013 18.6 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase Sec23_trunk PF04811.15 EFC43377.1 - 0.00061 19.4 0.2 0.0027 17.3 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain zf-Sec23_Sec24 PF04810.15 EFC43377.1 - 0.0016 18.4 4.2 0.0084 16.1 4.2 2.3 1 1 0 1 1 1 1 Sec23/Sec24 zinc finger VWA_2 PF13519.6 EFC43377.1 - 0.0039 17.8 2.6 4.8 7.9 0.1 3.8 3 1 0 3 3 3 2 von Willebrand factor type A domain GTP_EFTU PF00009.27 EFC43377.1 - 0.0077 15.8 0.0 0.022 14.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain VWA_CoxE PF05762.14 EFC43377.1 - 0.075 12.4 0.0 0.43 9.9 0.0 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein DUF2076 PF09849.9 EFC43377.1 - 0.72 9.9 4.6 0.36 10.8 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4116 PF13475.6 EFC43378.1 - 5.3e-37 125.3 6.7 4.7e-14 51.8 0.0 11.2 8 2 4 12 12 12 9 Domain of unknown function (DUF4116) E1-E2_ATPase PF00122.20 EFC43379.1 - 7.6e-32 110.3 0.4 1.9e-31 109.0 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC43379.1 - 3e-13 50.5 0.1 8.8e-05 22.9 0.1 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC43379.1 - 0.0015 18.5 0.0 0.0037 17.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC43379.1 - 0.008 15.9 0.2 0.038 13.7 0.1 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ceramidase PF05875.12 EFC43379.1 - 0.59 9.5 5.1 0.43 10.0 0.5 2.3 2 0 0 2 2 2 0 Ceramidase MatE PF01554.18 EFC43380.1 - 6.8e-33 113.6 42.9 6.1e-24 84.5 12.9 4.4 5 0 0 5 5 5 2 MatE DUF3487 PF11990.8 EFC43380.1 - 0.032 14.1 0.5 0.032 14.1 0.5 4.5 5 1 2 7 7 7 0 Protein of unknown function (DUF3487) DUF2561 PF10812.8 EFC43380.1 - 0.14 12.2 1.4 0.35 10.9 1.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF4579 PF15158.6 EFC43380.1 - 0.42 10.3 4.0 2.3 8.0 2.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) ParA PF10609.9 EFC43381.1 - 2e-100 335.3 0.5 2.3e-100 335.1 0.5 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFC43381.1 - 7.2e-13 48.7 0.0 2.1e-12 47.2 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 EFC43381.1 - 2.3e-06 27.2 0.1 0.021 14.3 0.0 2.3 2 1 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 EFC43381.1 - 2.5e-06 27.0 0.0 3.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 EFC43381.1 - 3.7e-06 27.0 0.8 2.3e-05 24.4 0.3 2.0 1 1 1 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 EFC43381.1 - 6.8e-06 25.5 2.6 0.00073 18.8 0.5 3.0 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.6 EFC43381.1 - 0.035 13.7 1.2 0.039 13.5 0.2 1.5 2 0 0 2 2 2 0 AAA domain AAA_26 PF13500.6 EFC43381.1 - 0.063 13.1 0.6 7.9 6.2 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_33 PF13671.6 EFC43381.1 - 0.14 12.3 0.1 0.78 9.9 0.1 2.4 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 EFC43381.1 - 0.19 10.9 0.1 0.35 10.0 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain NUDIX PF00293.28 EFC43383.1 - 1.3e-17 64.1 0.1 2.1e-17 63.4 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain zf-Di19 PF05605.12 EFC43383.1 - 8.2e-07 29.2 6.9 5.9e-06 26.5 7.3 2.2 1 1 1 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 EFC43383.1 - 0.032 14.5 0.9 0.08 13.2 0.9 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon IBR PF01485.21 EFC43383.1 - 0.36 11.1 5.7 0.71 10.1 5.7 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF4363 PF14276.6 EFC43385.1 - 0.088 12.9 0.4 0.23 11.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) ABC2_membrane_3 PF12698.7 EFC43386.1 - 0.017 14.3 6.6 0.019 14.1 6.1 1.3 1 1 0 1 1 1 0 ABC-2 family transporter protein Sarcoglycan_1 PF04790.13 EFC43386.1 - 1.4 8.2 4.4 5 6.4 0.0 2.4 2 1 0 2 2 2 0 Sarcoglycan complex subunit protein ATG27 PF09451.10 EFC43386.1 - 1.6 8.5 6.8 0.11 12.3 1.2 1.9 1 1 1 2 2 2 0 Autophagy-related protein 27 Sigma_reg_N PF13800.6 EFC43386.1 - 2.7 8.4 5.3 1.6 9.0 0.3 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2207 PF09972.9 EFC43386.1 - 3.8 6.2 7.3 2.7 6.7 0.4 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DHHC PF01529.20 EFC43386.1 - 6.7 6.8 8.8 14 5.8 8.6 1.5 1 1 0 1 1 1 0 DHHC palmitoyltransferase Methyltransf_4 PF02390.17 EFC43387.1 - 7.2e-41 139.5 0.0 9.5e-41 139.1 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 EFC43387.1 - 0.00096 19.9 0.0 0.0017 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC43387.1 - 0.0022 17.8 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC43387.1 - 0.0036 18.0 0.0 0.0057 17.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC43387.1 - 0.082 12.5 0.0 0.26 10.8 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EFC43387.1 - 0.1 12.6 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Cofilin_ADF PF00241.20 EFC43388.1 - 3.9e-38 130.0 1.2 3.8e-24 84.8 0.3 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein MIT_C PF16565.5 EFC43388.1 - 0.18 11.8 2.7 0.18 11.8 0.3 2.0 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT Pex2_Pex12 PF04757.14 EFC43389.1 - 0.0038 16.8 0.1 0.0077 15.9 0.1 1.5 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region F-box-like PF12937.7 EFC43389.1 - 0.051 13.5 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC43389.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 F-box domain zf-FPG_IleRS PF06827.14 EFC43390.1 - 0.33 10.9 0.0 0.33 10.9 0.0 4.1 5 0 0 5 5 5 0 Zinc finger found in FPG and IleRS NOB1_Zn_bind PF08772.11 EFC43390.1 - 1.1 9.4 16.6 2 8.7 1.6 3.9 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like HNH PF01844.23 EFC43390.1 - 3.5 7.9 19.9 1.4 9.2 0.3 5.1 5 0 0 5 5 5 0 HNH endonuclease EF-hand_7 PF13499.6 EFC43391.1 - 0.00077 19.9 0.4 0.0018 18.7 0.1 1.7 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_9 PF14658.6 EFC43391.1 - 0.0012 19.2 0.0 0.002 18.4 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain DUF4698 PF15769.5 EFC43391.1 - 0.015 14.4 0.3 0.017 14.2 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) EF-hand_6 PF13405.6 EFC43391.1 - 0.015 15.2 0.3 0.092 12.7 0.1 2.3 3 0 0 3 3 3 0 EF-hand domain T3SS_HrpK1 PF16937.5 EFC43391.1 - 0.027 14.1 0.0 0.032 13.9 0.0 1.1 1 0 0 1 1 1 0 Type III secretion system translocator protein, HrpF GPHH PF16905.5 EFC43391.1 - 0.17 11.7 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated bZIP_1 PF00170.21 EFC43392.1 - 2.4e-05 24.3 13.7 2.4e-05 24.3 13.7 2.7 3 0 0 3 3 3 1 bZIP transcription factor DUF896 PF05979.12 EFC43392.1 - 0.045 13.6 6.9 0.095 12.6 6.0 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF896) HemY_N PF07219.13 EFC43392.1 - 0.052 13.8 0.1 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 HemY protein N-terminus MacB_PCD PF12704.7 EFC43392.1 - 0.071 13.4 0.4 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 MacB-like periplasmic core domain DUF2205 PF10224.9 EFC43392.1 - 2 8.5 13.4 21 5.2 12.6 2.6 1 1 1 2 2 2 0 Short coiled-coil protein FlaC_arch PF05377.11 EFC43392.1 - 3.2 8.2 5.3 2.5 8.6 1.1 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) YabA PF06156.13 EFC43392.1 - 4.7 7.9 12.2 0.18 12.4 3.5 2.8 1 1 1 2 2 2 0 Initiation control protein YabA Polyketide_cyc PF03364.20 EFC43393.1 - 4.3e-10 39.9 0.0 5.3e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport zf-CCHC PF00098.23 EFC43394.1 - 0.00016 21.6 0.2 0.0003 20.7 0.2 1.5 1 0 0 1 1 1 1 Zinc knuckle LAGLIDADG_3 PF14528.6 EFC43394.1 - 0.0091 16.3 0.1 0.053 13.9 0.1 2.3 1 0 0 1 1 1 1 LAGLIDADG-like domain Actin PF00022.19 EFC43396.1 - 1.3e-100 336.9 0.0 7.2e-99 331.1 0.0 2.0 1 1 0 1 1 1 1 Actin WD40 PF00400.32 EFC43397.1 - 1e-31 108.4 19.3 1.2e-07 32.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC43397.1 - 1.1e-14 54.5 1.1 0.0003 21.0 0.0 5.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC43397.1 - 2.4e-07 30.1 2.1 0.24 10.3 0.0 4.3 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC43397.1 - 6.9e-06 25.6 1.6 0.022 14.1 0.1 3.1 2 1 1 3 3 3 2 WD40-like domain VID27 PF08553.10 EFC43397.1 - 0.0089 15.1 0.2 0.052 12.6 0.1 1.9 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain Nup160 PF11715.8 EFC43397.1 - 0.046 12.4 1.2 0.51 8.9 0.1 2.6 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFC43397.1 - 0.083 11.4 0.3 0.51 8.8 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain Big_7 PF17957.1 EFC43397.1 - 0.53 11.1 3.3 49 4.8 0.0 4.0 3 1 0 3 3 3 0 Bacterial Ig domain Ribosomal_L29 PF00831.23 EFC43398.1 - 6.1e-21 74.2 3.3 6.1e-21 74.2 3.3 2.8 1 1 2 3 3 3 1 Ribosomal L29 protein PRKG1_interact PF15898.5 EFC43398.1 - 6.3 7.8 13.3 0.73 10.8 1.4 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Ras PF00071.22 EFC43399.1 - 2.9e-53 179.8 0.3 3.4e-53 179.6 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43399.1 - 1.6e-26 92.9 0.8 2.1e-26 92.5 0.2 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43399.1 - 1.7e-11 43.9 0.1 2e-11 43.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC43399.1 - 0.00031 20.2 0.2 0.00065 19.1 0.2 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 EFC43399.1 - 0.029 14.3 0.1 2.2 8.2 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 EFC43399.1 - 0.053 13.6 0.1 0.26 11.4 0.0 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase Guanylate_cyc PF00211.20 EFC43400.1 - 2.8e-51 173.7 0.9 4.8e-51 173.0 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC43400.1 - 5.6e-14 52.3 0.1 1.8e-13 50.6 0.1 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC43400.1 - 6.1e-10 39.1 0.0 1.4e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC43400.1 - 1.7e-06 28.3 0.0 2.8e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC43400.1 - 0.015 15.3 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_2 PF08446.11 EFC43400.1 - 0.071 13.8 0.1 0.23 12.1 0.1 1.8 1 0 0 1 1 1 0 PAS fold Iwr1 PF08574.10 EFC43401.1 - 0.00015 22.7 16.6 0.00015 22.7 16.6 3.6 4 2 0 4 4 4 1 Transcription factor Iwr1 EST1_DNA_bind PF10373.9 EFC43402.1 - 4.5e-18 65.7 12.9 4.5e-18 65.7 12.9 2.3 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain Kinesin PF00225.23 EFC43403.1 - 1.6e-106 356.1 6.1 1.6e-106 356.1 6.1 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC43403.1 - 4.4e-24 85.1 1.2 2e-23 82.9 0.1 2.8 2 0 0 2 2 2 1 Microtubule binding PH PF00169.29 EFC43403.1 - 0.039 14.5 0.5 0.039 14.5 0.5 3.0 3 0 0 3 3 3 0 PH domain Cpn60_TCP1 PF00118.24 EFC43404.1 - 2.4e-105 353.0 0.1 1.6e-104 350.3 0.1 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pkinase PF00069.25 EFC43406.1 - 4.7e-62 209.7 0.3 1.1e-61 208.5 0.3 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43406.1 - 3.5e-36 124.8 0.1 1.5e-35 122.7 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase GFO_IDH_MocA PF01408.22 EFC43407.1 - 4.1e-22 79.3 0.0 6.4e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 EFC43407.1 - 8.5e-06 26.4 0.0 1.6e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 EFC43407.1 - 0.0076 16.7 0.0 0.015 15.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFC43407.1 - 0.022 15.3 0.0 0.045 14.3 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 EFC43407.1 - 0.023 15.0 0.0 0.041 14.1 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFC43407.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Med11 PF10280.9 EFC43408.1 - 0.0046 17.4 8.9 0.01 16.3 1.3 3.4 3 0 0 3 3 3 2 Mediator complex protein TPR_2 PF07719.17 EFC43409.1 - 0.001 19.0 0.5 0.011 15.8 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC43409.1 - 0.021 14.6 0.0 0.21 11.5 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_8 PF13855.6 EFC43410.1 - 2.6e-05 23.9 10.8 0.0092 15.7 1.3 4.0 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC43410.1 - 0.00012 22.4 17.2 1.7 9.2 3.7 6.2 4 1 2 6 6 6 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC43410.1 - 0.16 12.1 0.6 32 4.9 0.0 3.6 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 EFC43410.1 - 0.54 11.0 4.3 4 8.4 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat PRANC PF09372.10 EFC43410.1 - 9.2 6.7 10.8 2.5 8.5 0.1 3.6 3 1 1 4 4 4 0 PRANC domain Guanylate_cyc PF00211.20 EFC43411.1 - 1.9e-51 174.3 0.1 4.3e-51 173.2 0.1 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC43411.1 - 1.1e-21 77.1 0.4 4.8e-21 75.0 0.4 2.3 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC43411.1 - 6.3e-05 23.0 0.0 0.00014 21.8 0.0 1.7 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC43411.1 - 0.00076 19.0 0.3 0.0024 17.3 0.3 1.9 1 0 0 1 1 1 1 Heme NO binding associated YajC PF02699.15 EFC43411.1 - 2.5 8.1 7.0 0.22 11.4 1.1 2.5 2 0 0 2 2 2 0 Preprotein translocase subunit CPP1-like PF11833.8 EFC43411.1 - 2.9 7.5 6.1 4.9 6.8 3.5 2.6 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Guanylate_cyc PF00211.20 EFC43412.1 - 9.3e-52 175.3 0.1 3.1e-51 173.6 0.1 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC43412.1 - 5.9e-22 77.9 0.5 3.1e-21 75.6 0.5 2.4 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC43412.1 - 3.3e-05 23.9 0.0 0.0001 22.3 0.0 1.9 1 1 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC43412.1 - 0.00064 19.2 0.3 0.0019 17.7 0.3 1.8 1 0 0 1 1 1 1 Heme NO binding associated EGF_2 PF07974.13 EFC43413.1 - 2.4e-36 123.8 126.3 3e-05 24.3 11.8 8.6 8 0 0 8 8 8 8 EGF-like domain EGF PF00008.27 EFC43413.1 - 2.1e-07 31.1 105.4 0.0043 17.3 4.0 10.4 9 1 1 10 10 10 8 EGF-like domain EGF_Tenascin PF18720.1 EFC43413.1 - 0.014 15.5 4.0 0.014 15.5 4.0 8.5 8 0 0 8 8 8 0 Tenascin EGF domain G-alpha PF00503.20 EFC43414.1 - 2.2e-43 148.8 14.7 3.8e-43 148.0 14.7 1.4 1 0 0 1 1 1 1 G-protein alpha subunit RGS PF00615.19 EFC43416.1 - 7.9e-06 26.1 0.9 2.2e-05 24.7 0.9 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF2271 PF10029.9 EFC43416.1 - 0.019 14.6 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) Pex24p PF06398.11 EFC43416.1 - 1.3 7.9 8.7 0.56 9.1 5.5 1.9 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin Protamine_P2 PF00841.19 EFC43417.1 - 1.2 9.6 14.5 1.9 9.0 13.9 1.6 2 0 0 2 2 2 0 Sperm histone P2 RCC1_2 PF13540.6 EFC43418.1 - 0.00024 20.8 19.9 0.13 12.1 0.9 5.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC43418.1 - 0.24 12.1 5.9 72 4.1 0.0 5.3 6 0 0 6 6 6 0 Regulator of chromosome condensation (RCC1) repeat Acetyltransf_9 PF13527.7 EFC43420.1 - 4.6e-13 49.4 0.0 8.2e-06 25.9 0.0 2.7 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC43420.1 - 1.1e-06 29.0 0.0 1.2e-05 25.7 0.0 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC43420.1 - 8e-06 25.8 0.0 0.00019 21.3 0.0 2.7 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC43420.1 - 8.2e-06 26.0 0.0 4.9e-05 23.6 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_17 PF17668.1 EFC43420.1 - 0.0051 17.6 0.0 0.011 16.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC43420.1 - 0.0094 15.9 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 EFC43420.1 - 0.01 15.3 0.0 0.027 14.0 0.0 1.7 1 1 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_13 PF13880.6 EFC43420.1 - 0.1 12.6 0.0 0.81 9.7 0.0 2.4 2 1 0 2 2 2 0 ESCO1/2 acetyl-transferase DUF1425 PF07233.12 EFC43420.1 - 0.13 12.2 0.2 0.44 10.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1425) DEP PF00610.21 EFC43422.1 - 3.5e-14 52.6 0.1 6.3e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) RGS PF00615.19 EFC43422.1 - 2.4e-12 47.1 0.4 2.4e-12 47.1 0.4 2.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain XOO_2897-deam PF14440.6 EFC43422.1 - 0.16 12.1 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Ntox11 PF15521.6 EFC43423.1 - 9.5e-121 402.5 1.4 1.3e-120 402.1 1.4 1.1 1 0 0 1 1 1 1 Novel toxin 11 RBR PF17208.3 EFC43423.1 - 0.03 15.0 1.9 0.13 13.0 1.9 2.2 1 0 0 1 1 1 0 RNA binding Region RCC1 PF00415.18 EFC43425.1 - 9.7e-42 141.4 8.8 3.1e-09 37.3 0.3 6.5 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43425.1 - 1.7e-39 132.8 24.5 3.4e-10 39.5 0.7 7.8 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC43425.1 - 4e-12 45.8 20.6 1.6e-08 34.4 0.4 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 EFC43425.1 - 0.00031 20.9 18.1 0.49 10.8 0.3 6.2 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EFC43425.1 - 0.0057 16.6 18.4 1 9.5 0.5 5.9 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC43425.1 - 6.9 6.8 19.7 0.26 11.3 0.2 5.0 6 0 0 6 6 6 0 Kelch motif TraB PF01963.17 EFC43426.1 - 1.4e-15 57.9 0.0 3e-10 40.4 0.0 3.2 2 1 0 2 2 2 2 TraB family Jnk-SapK_ap_N PF09744.9 EFC43427.1 - 0.00051 20.3 22.8 0.00051 20.3 22.8 7.1 3 1 4 8 8 8 2 JNK_SAPK-associated protein-1 BST2 PF16716.5 EFC43427.1 - 0.012 16.2 10.8 0.012 16.2 10.8 8.9 5 1 4 9 9 9 0 Bone marrow stromal antigen 2 SlyX PF04102.12 EFC43427.1 - 0.046 14.3 0.8 0.046 14.3 0.8 9.2 6 3 3 9 9 9 0 SlyX LRR_6 PF13516.6 EFC43427.1 - 0.052 13.6 0.2 0.22 11.6 0.2 2.2 1 0 0 1 1 1 0 Leucine Rich repeat DUF3800 PF12686.7 EFC43427.1 - 0.2 12.3 10.4 2.9e+03 -1.2 10.4 5.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) RCC1 PF00415.18 EFC43429.1 - 2.6e-75 248.9 14.7 5e-11 43.1 0.0 8.1 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43429.1 - 1.5e-56 187.2 21.2 1.2e-08 34.6 0.7 8.3 8 0 0 8 8 8 8 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC43429.1 - 0.39 11.0 4.6 8.1 6.8 0.3 3.7 2 2 0 2 2 2 0 Putative heavy-metal chelation DUF4428 PF14471.6 EFC43431.1 - 0.025 14.5 2.3 0.025 14.5 2.3 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) Phage_int_SAM_5 PF13102.6 EFC43432.1 - 7.4e-07 29.4 3.4 7.4e-07 29.4 0.7 2.4 2 1 0 2 2 2 1 Phage integrase SAM-like domain Phage_int_SAM_4 PF13495.6 EFC43432.1 - 0.11 13.0 0.6 0.11 13.0 0.6 2.5 3 1 1 4 4 4 0 Phage integrase, N-terminal SAM-like domain DUF3776 PF12618.8 EFC43432.1 - 0.4 11.3 3.8 0.34 11.5 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3776) Exo_endo_phos_2 PF14529.6 EFC43434.1 - 0.00097 19.0 0.1 0.0046 16.8 0.1 2.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RCC1 PF00415.18 EFC43435.1 - 1.7e-43 147.0 6.7 3e-09 37.3 0.0 5.6 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43435.1 - 8.7e-27 92.3 21.9 5.2e-06 26.1 1.7 6.5 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC43435.1 - 3.5e-08 33.2 10.1 3.2e-06 27.0 0.7 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EFC43435.1 - 0.084 13.2 12.4 4.2 7.8 0.1 5.8 6 0 0 6 6 6 0 Kelch motif Kelch_4 PF13418.6 EFC43435.1 - 1.1 9.4 16.0 20 5.3 0.3 5.7 6 0 0 6 6 6 0 Galactose oxidase, central domain RCC1 PF00415.18 EFC43436.1 - 1.2e-37 128.2 9.9 4.4e-07 30.4 0.1 8.2 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43436.1 - 5.2e-24 83.5 26.6 4.2e-07 29.6 0.1 7.9 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC43436.1 - 1.7e-14 53.4 15.5 4.5e-05 23.3 0.5 6.3 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 EFC43436.1 - 1.2e-06 28.6 23.3 0.86 10.0 0.1 8.6 10 0 0 10 10 10 4 Kelch motif Kelch_1 PF01344.25 EFC43436.1 - 1.2e-06 28.0 12.1 0.4 10.3 0.1 5.8 5 0 0 5 5 5 4 Kelch motif Fibrinogen_C PF00147.18 EFC43436.1 - 3.4e-05 23.8 0.1 8.8e-05 22.4 0.1 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Kelch_4 PF13418.6 EFC43436.1 - 0.0065 16.5 17.9 5.8 7.0 0.0 7.1 8 0 0 8 8 8 1 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC43436.1 - 0.0094 15.9 12.6 38 4.5 0.0 6.6 6 0 0 6 6 6 0 Kelch motif Kelch_3 PF13415.6 EFC43436.1 - 0.51 10.7 13.3 7.1 7.1 0.1 5.1 4 0 0 4 4 4 0 Galactose oxidase, central domain EGF_2 PF07974.13 EFC43436.1 - 2.7 8.4 15.7 0.025 14.9 6.9 2.3 2 0 0 2 2 2 0 EGF-like domain Pkinase PF00069.25 EFC43437.1 - 3.5e-14 52.8 0.1 7.9e-14 51.6 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43437.1 - 2.1e-10 40.3 0.0 5.4e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Phage_lysozyme PF00959.19 EFC43438.1 - 0.0014 19.1 0.0 0.0029 18.1 0.0 1.5 1 0 0 1 1 1 1 Phage lysozyme SH3_3 PF08239.11 EFC43438.1 - 0.02 15.2 0.0 1.6 9.0 0.0 2.7 2 0 0 2 2 2 0 Bacterial SH3 domain Pkinase PF00069.25 EFC43440.1 - 8.8e-46 156.4 1.8 1.4e-45 155.8 1.8 1.2 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC43440.1 - 2.2e-42 141.0 8.7 4e-06 26.6 0.0 10.9 10 0 0 10 10 10 8 NHL repeat Pkinase_Tyr PF07714.17 EFC43440.1 - 2e-28 99.4 0.4 3.2e-28 98.7 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC43440.1 - 1.1e-16 60.8 99.3 0.00039 20.7 9.5 6.6 6 0 0 6 6 6 6 EGF-like domain SGL PF08450.12 EFC43440.1 - 2.2e-09 37.3 6.3 0.094 12.3 0.2 5.0 4 1 1 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC43440.1 - 7.1e-05 22.9 6.7 0.58 10.4 0.0 6.2 6 2 2 8 8 8 2 Arylesterase Str_synth PF03088.16 EFC43440.1 - 7.6e-05 22.8 0.4 4.4 7.5 0.0 6.5 5 3 1 6 6 6 1 Strictosidine synthase EGF PF00008.27 EFC43440.1 - 0.0002 21.6 77.2 0.039 14.3 4.7 6.7 6 0 0 6 6 6 4 EGF-like domain Pkinase_fungal PF17667.1 EFC43440.1 - 0.0012 17.7 0.0 0.0018 17.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Phytase-like PF13449.6 EFC43440.1 - 0.0019 18.2 0.1 0.99 9.3 0.0 4.4 4 2 0 4 4 4 1 Esterase-like activity of phytase Mid2 PF04478.12 EFC43440.1 - 0.014 15.2 0.1 0.039 13.8 0.1 1.7 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor hEGF PF12661.7 EFC43440.1 - 0.022 15.4 81.1 0.12 13.1 4.4 6.8 6 0 0 6 6 6 0 Human growth factor-like EGF EB PF01683.18 EFC43440.1 - 7.8 6.9 79.1 1.2 9.5 4.8 6.4 5 1 1 6 6 6 0 EB module DUF4116 PF13475.6 EFC43442.1 - 3.4e-13 49.1 6.1 9.8e-05 22.0 0.3 4.5 3 1 1 4 4 4 3 Domain of unknown function (DUF4116) PhoLip_ATPase_C PF16212.5 EFC43443.1 - 1e-85 287.5 30.2 1e-85 287.5 30.2 1.6 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC43443.1 - 5.3e-28 96.5 0.7 4.2e-27 93.6 0.1 2.6 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFC43443.1 - 8.7e-11 41.7 4.3 1e-10 41.4 0.0 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFC43443.1 - 1.1e-09 38.9 0.2 1.8e-05 25.1 0.1 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC43443.1 - 1.8e-09 37.5 0.1 2.4e-08 33.9 0.0 2.8 4 0 0 4 4 4 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC43443.1 - 0.052 13.3 1.9 0.095 12.4 0.2 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase CdvA PF18822.1 EFC43443.1 - 0.4 10.5 3.7 0.84 9.5 0.2 2.7 3 0 0 3 3 3 0 CdvA-like coiled-coil domain Glyco_hydro_19 PF00182.19 EFC43444.1 - 3e-19 69.8 0.6 5e-18 65.8 0.2 2.4 1 1 1 2 2 2 1 Chitinase class I TetR_C_7 PF14246.6 EFC43444.1 - 0.18 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal domain DUF1615 PF07759.12 EFC43446.1 - 0.046 12.9 1.2 1.3 8.2 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1615) SH2 PF00017.24 EFC43447.1 - 8e-11 41.9 0.1 2.2e-10 40.5 0.1 1.9 1 0 0 1 1 1 1 SH2 domain Cbl_N2 PF02761.14 EFC43447.1 - 7.3e-06 26.6 1.5 2.1e-05 25.1 1.5 1.8 1 0 0 1 1 1 1 CBL proto-oncogene N-terminus, EF hand-like domain LAGLIDADG_WhiA PF14527.6 EFC43447.1 - 0.13 12.4 0.1 0.36 10.9 0.1 1.7 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain Clr2 PF10383.9 EFC43447.1 - 0.17 12.7 0.6 0.59 10.9 0.6 2.0 1 1 0 1 1 1 0 Transcription-silencing protein Clr2 Metallophos PF00149.28 EFC43449.1 - 1.7e-17 64.6 4.6 3.3e-17 63.7 4.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFC43449.1 - 3.8e-14 53.0 1.2 6.5e-14 52.3 0.2 2.0 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFC43449.1 - 2.1e-07 31.7 1.5 3.5e-07 31.0 0.0 2.2 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Phage_TAC_4 PF08748.11 EFC43450.1 - 0.074 13.4 0.1 0.26 11.6 0.0 2.1 2 0 0 2 2 2 0 Phage tail assembly chaperone DUF620 PF04788.12 EFC43450.1 - 0.074 12.5 0.0 0.16 11.4 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF620) DUF4502 PF14950.6 EFC43450.1 - 0.31 10.4 3.0 0.46 9.9 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4502) SBP_bac_3 PF00497.20 EFC43451.1 - 9.7e-25 87.3 0.0 2.7e-11 43.3 0.0 2.1 2 0 0 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 NA37 PF04245.13 EFC43451.1 - 0.0055 16.2 0.5 1.7 8.1 0.0 2.1 2 0 0 2 2 2 2 37-kD nucleoid-associated bacterial protein SUV3_C PF12513.8 EFC43451.1 - 0.021 14.7 0.2 9.8 6.2 0.0 2.7 2 0 0 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal Lig_chan-Glu_bd PF10613.9 EFC43451.1 - 0.025 14.7 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 0 Ligated ion channel L-glutamate- and glycine-binding site motB PF17613.2 EFC43451.1 - 0.12 12.3 0.0 15 5.4 0.0 2.4 2 0 0 2 2 2 0 Modifier of transcription Kelch_4 PF13418.6 EFC43452.1 - 2.7e-08 33.7 0.3 2.1e-06 27.6 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC43452.1 - 4.1e-07 30.0 0.7 0.0096 16.2 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 EFC43452.1 - 2.8e-05 24.3 0.0 0.02 15.2 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC43452.1 - 0.014 15.0 0.4 0.097 12.3 0.0 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 EFC43452.1 - 0.015 15.3 0.2 5.8 7.0 0.0 2.8 2 0 0 2 2 2 0 Kelch motif KH_9 PF17904.1 EFC43454.1 - 0.1 13.0 0.4 0.5 10.8 0.5 2.1 2 0 0 2 2 2 0 FMRP KH0 domain Ras PF00071.22 EFC43456.1 - 1.4e-20 73.5 0.0 1.9e-20 73.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43456.1 - 8.3e-13 48.6 0.0 1.1e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43456.1 - 9.2e-09 35.0 0.0 1.2e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC43456.1 - 1.9e-05 24.7 0.0 2.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC43456.1 - 0.00059 19.4 0.0 0.0011 18.6 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC43456.1 - 0.009 15.9 0.1 2.4 8.0 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFC43456.1 - 0.012 15.0 0.1 0.017 14.5 0.1 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 EFC43456.1 - 0.019 15.0 0.7 0.035 14.1 0.7 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 EFC43456.1 - 0.079 13.0 0.3 7.3 6.6 0.1 2.1 1 1 0 2 2 2 0 Dynamin family AMP-binding PF00501.28 EFC43457.1 - 8.7e-46 156.4 0.0 1.2e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC43457.1 - 0.042 14.8 0.0 0.11 13.5 0.0 1.8 1 1 0 1 1 1 0 AMP-binding enzyme C-terminal domain F-box-like PF12937.7 EFC43458.1 - 6.4e-07 29.2 0.0 2.2e-06 27.5 0.0 2.0 1 0 0 1 1 1 1 F-box-like F-box_5 PF18511.1 EFC43458.1 - 0.027 14.0 0.0 0.059 13.0 0.0 1.6 1 0 0 1 1 1 0 F-box F-box PF00646.33 EFC43458.1 - 0.17 11.8 0.0 0.17 11.8 0.0 3.1 3 0 0 3 3 3 0 F-box domain ABC_membrane_2 PF06472.15 EFC43459.1 - 1.5e-56 191.8 2.5 2e-56 191.4 2.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 EFC43459.1 - 1.1e-22 81.0 0.0 2.8e-21 76.5 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EFC43459.1 - 5.7e-07 29.5 4.4 5.7e-07 29.5 4.4 1.6 1 1 1 2 2 2 1 ABC transporter transmembrane region Rad17 PF03215.15 EFC43459.1 - 0.00021 21.3 0.0 0.00048 20.1 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 EFC43459.1 - 0.00029 21.1 0.0 0.00076 19.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFC43459.1 - 0.0015 18.3 0.0 0.097 12.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 EFC43459.1 - 0.0042 16.5 0.0 1.1 8.7 0.0 2.5 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC43459.1 - 0.0074 16.7 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC43459.1 - 0.0092 15.7 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFC43459.1 - 0.014 15.3 0.3 0.06 13.2 0.2 2.0 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC43459.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EFC43459.1 - 0.024 15.2 0.0 0.06 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EFC43459.1 - 0.024 14.4 0.0 0.54 9.9 0.0 2.5 3 0 0 3 3 3 0 Cytidylate kinase DUF815 PF05673.13 EFC43459.1 - 0.05 12.8 0.0 0.091 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Lig_chan PF00060.26 EFC43459.1 - 0.078 12.8 0.3 0.22 11.3 0.1 1.9 2 0 0 2 2 2 0 Ligand-gated ion channel AAA PF00004.29 EFC43459.1 - 0.11 12.9 0.0 0.56 10.6 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFC43459.1 - 0.11 12.9 0.1 0.38 11.1 0.0 1.9 2 0 0 2 2 2 0 RNA helicase AAA_5 PF07728.14 EFC43459.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 EFC43459.1 - 0.16 11.3 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family U-box PF04564.15 EFC43460.1 - 1.5e-06 28.3 1.3 1.9e-05 24.7 0.0 3.0 3 0 0 3 3 3 1 U-box domain zf-Nse PF11789.8 EFC43460.1 - 0.043 13.6 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 EFC43460.1 - 0.094 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Ank_4 PF13637.6 EFC43461.1 - 2.9e-09 37.3 0.1 6.4e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC43461.1 - 9.1e-07 29.4 0.2 1.9e-06 28.4 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC43461.1 - 4.5e-06 26.8 1.1 7.9e-05 22.9 0.4 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC43461.1 - 6.7e-05 23.0 1.6 0.0093 16.4 0.1 3.5 4 0 0 4 4 3 1 Ankyrin repeat Ank PF00023.30 EFC43461.1 - 0.00014 22.1 1.0 0.00035 20.9 0.3 2.0 2 0 0 2 2 2 1 Ankyrin repeat HMw1_D2 PF18254.1 EFC43461.1 - 0.051 13.9 0.0 1.6 9.2 0.0 3.0 3 0 0 3 3 2 0 HMW1 domain 2 F-box PF00646.33 EFC43461.1 - 0.083 12.8 0.7 0.45 10.5 0.2 2.4 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EFC43461.1 - 0.14 12.1 1.1 0.97 9.4 0.4 2.4 2 0 0 2 2 2 0 F-box-like DUF728 PF05304.12 EFC43461.1 - 0.2 11.5 1.5 0.41 10.5 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF728) CDC45 PF02724.14 EFC43461.1 - 0.29 9.4 8.9 0.38 9.0 8.9 1.2 1 0 0 1 1 1 0 CDC45-like protein PPL5 PF18168.1 EFC43461.1 - 1.5 8.1 6.8 2.6 7.3 6.8 1.4 1 0 0 1 1 1 0 Prim-pol family 5 ALMT PF11744.8 EFC43461.1 - 6.5 5.5 10.1 9 5.0 10.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3337 PF11816.8 EFC43462.1 - 1.1e-16 61.2 1.2 3.7e-16 59.5 1.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 EFC43462.1 - 1.8e-08 34.9 15.9 9.8e-06 26.2 0.4 6.0 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC43462.1 - 5.4e-05 23.4 0.0 0.011 16.1 0.0 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC43462.1 - 0.0005 19.5 0.2 0.00089 18.7 0.2 1.4 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 EFC43462.1 - 0.0015 17.3 0.4 0.0029 16.3 0.4 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 PQQ PF01011.21 EFC43462.1 - 0.0048 16.8 0.3 11 6.2 0.1 3.7 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_3 PF13570.6 EFC43462.1 - 0.17 12.4 0.1 16 6.1 0.1 3.6 4 0 0 4 4 4 0 PQQ-like domain NDUFA12 PF05071.16 EFC43463.1 - 1.7e-10 41.6 2.1 2.1e-10 41.3 0.4 2.1 2 1 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Ank_2 PF12796.7 EFC43465.1 - 7.2e-14 52.1 0.1 0.00011 22.7 0.0 3.4 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC43465.1 - 2.9e-11 42.5 0.4 2.2e-05 24.5 0.0 4.2 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 EFC43465.1 - 5.7e-10 39.2 0.1 0.0023 18.3 0.0 3.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 EFC43465.1 - 2.5e-09 37.2 0.2 0.00038 20.7 0.0 3.9 3 1 0 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC43465.1 - 4.4e-08 33.5 0.0 0.00015 22.3 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) CAS_C PF12026.8 EFC43466.1 - 0.18 11.9 4.0 0.32 11.1 4.0 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Leu_zip PF15294.6 EFC43467.1 - 0.00016 21.3 1.3 0.00016 21.3 1.3 1.2 1 0 0 1 1 1 1 Leucine zipper DUF3827 PF12877.7 EFC43467.1 - 0.0083 14.6 1.0 0.0095 14.4 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) TSC22 PF01166.18 EFC43467.1 - 0.028 14.7 2.5 0.24 11.7 2.5 2.2 1 1 0 1 1 1 0 TSC-22/dip/bun family DivIC PF04977.15 EFC43467.1 - 0.058 13.2 9.7 0.1 12.4 9.7 1.4 1 0 0 1 1 1 0 Septum formation initiator PspB PF06667.12 EFC43467.1 - 0.084 12.9 0.2 0.14 12.3 0.2 1.4 1 0 0 1 1 1 0 Phage shock protein B Atg14 PF10186.9 EFC43467.1 - 0.089 11.9 3.4 0.11 11.6 3.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 EFC43467.1 - 0.095 13.3 4.6 0.086 13.5 3.4 1.6 1 1 0 1 1 1 0 Initiation control protein YabA SlyX PF04102.12 EFC43467.1 - 0.16 12.6 5.9 0.11 13.1 4.3 1.6 2 0 0 2 2 2 0 SlyX Csm1_N PF18504.1 EFC43467.1 - 0.18 12.2 9.0 0.29 11.5 9.0 1.3 1 0 0 1 1 1 0 Csm1 N-terminal domain TMEM192 PF14802.6 EFC43467.1 - 0.24 10.5 0.3 0.32 10.1 0.3 1.2 1 0 0 1 1 1 0 TMEM192 family DUF4337 PF14235.6 EFC43467.1 - 0.24 11.5 0.8 0.26 11.4 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Herpes_UL6 PF01763.16 EFC43467.1 - 0.66 8.4 3.9 0.83 8.1 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like ZapB PF06005.12 EFC43467.1 - 0.9 10.0 11.2 0.24 11.9 8.1 1.6 2 0 0 2 2 2 0 Cell division protein ZapB Response_reg PF00072.24 EFC43468.1 - 9.8e-24 83.7 0.0 1.2e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain PDEase_I PF00233.19 EFC43469.1 - 2.7e-81 272.8 0.6 3.1e-81 272.6 0.6 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EFC43469.1 - 0.0075 16.5 0.0 0.0098 16.1 0.0 1.3 1 0 0 1 1 1 1 HD domain Peptidase_C97 PF05903.14 EFC43469.1 - 0.04 13.7 0.4 0.073 12.9 0.4 1.3 1 0 0 1 1 1 0 PPPDE putative peptidase domain Tfb4 PF03850.14 EFC43470.1 - 2.6e-78 263.3 2.8 4.1e-78 262.7 2.8 1.3 1 1 0 1 1 1 1 Transcription factor Tfb4 DUF4428 PF14471.6 EFC43470.1 - 0.0079 16.1 2.9 0.17 11.8 0.1 2.9 2 1 1 3 3 3 2 Domain of unknown function (DUF4428) Glyco_hydro_38N PF01074.22 EFC43471.1 - 4.6e-56 190.3 1.1 4.6e-56 190.3 1.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 EFC43471.1 - 1.2e-17 63.8 0.1 3.2e-17 62.5 0.1 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 EFC43471.1 - 4.6e-17 62.8 0.3 7.4e-17 62.1 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain ABC_tran PF00005.27 EFC43472.1 - 2.1e-26 93.1 0.0 2.4e-15 57.3 0.0 2.7 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 EFC43472.1 - 7.2e-11 41.9 1.2 0.002 17.6 0.0 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFC43472.1 - 3.1e-08 33.8 6.5 0.015 15.1 0.0 4.0 3 2 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFC43472.1 - 0.00069 19.9 0.0 0.0017 18.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EFC43472.1 - 0.0012 18.7 2.5 0.0092 15.7 2.5 2.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFC43472.1 - 0.0057 16.6 0.0 0.017 15.1 0.0 1.8 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 EFC43472.1 - 0.0088 16.4 0.0 0.057 13.8 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFC43472.1 - 0.019 14.9 0.0 0.049 13.5 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 EFC43472.1 - 0.02 14.9 0.0 0.048 13.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SbcCD_C PF13558.6 EFC43472.1 - 0.033 14.4 0.0 9.5 6.5 0.0 3.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA PF00004.29 EFC43472.1 - 0.033 14.6 0.0 0.081 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFC43472.1 - 0.036 13.8 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC43472.1 - 0.07 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 EFC43472.1 - 0.095 13.2 0.1 0.095 13.2 0.1 2.8 3 0 0 3 3 3 0 AAA domain Pribosyltran_N PF13793.6 EFC43473.1 - 8.9e-45 151.4 3.4 2.2e-44 150.1 0.7 2.4 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFC43473.1 - 2.6e-31 109.1 0.8 1.7e-30 106.5 0.1 2.1 2 1 0 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFC43473.1 - 6.8e-11 41.9 0.4 5.8e-10 38.9 0.1 2.6 1 1 1 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFC43473.1 - 0.036 13.5 0.1 0.076 12.4 0.0 1.6 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase DUF995 PF06191.12 EFC43473.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF995) Lipase_GDSL PF00657.22 EFC43474.1 - 1.1e-17 64.7 0.0 1.4e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 EFC43474.1 - 9.8e-17 61.9 0.0 1.7e-16 61.2 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family RGS PF00615.19 EFC43476.1 - 9.7e-08 32.3 1.2 2e-07 31.3 1.2 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain CitMHS PF03600.16 EFC43476.1 - 0.11 11.7 7.2 0.16 11.1 7.2 1.3 1 0 0 1 1 1 0 Citrate transporter PhoQ_Sensor PF08918.10 EFC43476.1 - 0.2 11.5 1.3 0.71 9.7 0.0 2.2 2 0 0 2 2 2 0 PhoQ Sensor GTP_EFTU PF00009.27 EFC43477.1 - 7.9e-63 211.5 0.1 1.3e-62 210.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EFC43477.1 - 1.8e-29 101.6 0.1 4.6e-29 100.3 0.1 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFC43477.1 - 9.4e-26 89.7 0.1 2.1e-25 88.6 0.1 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 EFC43477.1 - 1.8e-08 34.3 0.0 3.7e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 EFC43477.1 - 1.1e-07 31.7 0.0 2.4e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 EFC43477.1 - 1.6e-07 31.6 0.3 5e-07 30.0 0.3 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC43477.1 - 0.00015 21.8 0.0 0.00042 20.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC43477.1 - 0.076 12.5 0.0 0.28 10.7 0.0 1.9 1 0 0 1 1 1 0 Ferrous iron transport protein B SRPRB PF09439.10 EFC43477.1 - 0.12 11.8 0.0 0.39 10.1 0.0 2.0 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AvrPtoB_bdg PF16847.5 EFC43477.1 - 0.13 12.8 0.0 1.9 9.0 0.0 2.7 3 0 0 3 3 3 0 Avirulence AvrPtoB, BAK1-binding domain Cir_N PF10197.9 EFC43478.1 - 1.1e-10 41.4 8.8 1.1e-10 41.4 8.8 4.7 5 1 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR zf-CCHC_6 PF15288.6 EFC43478.1 - 2.7e-05 23.9 0.2 7.6e-05 22.5 0.2 1.8 1 0 0 1 1 1 1 Zinc knuckle HMG_box PF00505.19 EFC43480.1 - 3.1e-24 85.2 8.8 2.2e-19 69.6 2.7 3.6 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC43480.1 - 4.6e-13 49.6 7.0 8.3e-08 32.7 3.1 3.5 4 0 0 4 4 4 2 HMG-box domain CHDNT PF08073.12 EFC43480.1 - 5.6e-06 26.2 0.3 1.1e-05 25.3 0.3 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain FAM178 PF14816.6 EFC43480.1 - 0.2 10.6 8.9 0.36 9.7 8.9 1.3 1 0 0 1 1 1 0 Family of unknown function, FAM178 DUF1644 PF07800.12 EFC43480.1 - 1 9.4 7.4 14 5.7 7.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) PIEZO PF15917.5 EFC43480.1 - 3.9 6.9 21.5 0.064 12.7 10.8 2.1 2 0 0 2 2 2 0 Piezo YABBY PF04690.13 EFC43480.1 - 4.9 7.7 13.2 3 8.4 0.7 2.1 2 0 0 2 2 2 0 YABBY protein DUF1664 PF07889.12 EFC43481.1 - 0.069 13.2 4.1 0.14 12.2 4.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Uds1 PF15456.6 EFC43481.1 - 0.13 12.4 1.8 0.97 9.6 0.3 2.2 1 1 1 2 2 2 0 Up-regulated During Septation APG6_N PF17675.1 EFC43481.1 - 1.1 9.8 10.8 15 6.1 10.8 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region LRR_8 PF13855.6 EFC43482.1 - 2.3e-17 62.5 22.1 1.2e-10 41.0 2.2 5.0 5 0 0 5 5 5 4 Leucine rich repeat LRR_6 PF13516.6 EFC43482.1 - 1.4e-16 59.0 38.3 0.00044 20.1 0.1 10.5 12 2 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.7 EFC43482.1 - 1e-13 51.2 32.7 4.7e-05 23.7 0.7 8.1 2 1 7 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC43482.1 - 0.57 10.9 26.2 5 8.1 0.1 7.9 9 2 0 9 9 9 0 Leucine Rich Repeat GIDA PF01134.22 EFC43484.1 - 9.6e-124 413.4 0.1 3.5e-123 411.6 0.1 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 EFC43484.1 - 3.7e-28 99.2 2.1 7.8e-28 98.1 2.1 1.6 1 0 0 1 1 1 1 GidA associated domain NAD_binding_9 PF13454.6 EFC43484.1 - 7.8e-05 22.7 0.1 0.0011 18.9 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFC43484.1 - 0.00082 18.7 2.9 0.0052 16.1 1.4 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC43484.1 - 0.019 14.1 0.1 0.11 11.5 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 EFC43484.1 - 0.054 14.1 0.7 5.3 7.7 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFC43484.1 - 0.15 11.4 0.1 0.25 10.6 0.1 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase SOG2 PF10428.9 EFC43485.1 - 0.0046 16.2 26.2 0.0052 16.0 26.2 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein BLI1 PF17324.2 EFC43485.1 - 0.017 15.7 1.9 0.066 13.9 0.2 2.2 2 0 0 2 2 2 0 BLOC-1 interactor 1 RasGEF PF00617.19 EFC43486.1 - 8e-62 208.6 0.8 8e-62 208.6 0.8 2.4 3 1 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 EFC43486.1 - 4.8e-19 68.5 4.0 4.8e-19 68.5 4.0 2.6 3 0 0 3 3 3 1 RasGEF N-terminal motif BBL5 PF07289.11 EFC43487.1 - 2.1e-139 464.2 1.1 2.4e-139 464.0 1.1 1.0 1 0 0 1 1 1 1 Bardet-Biedl syndrome 5 protein bPH_3 PF14470.6 EFC43487.1 - 3e-08 33.9 0.3 3.4e-07 30.5 0.0 2.6 2 1 1 3 3 3 1 Bacterial PH domain Vps36_ESCRT-II PF11605.8 EFC43487.1 - 2.3e-06 27.7 0.1 0.0083 16.3 0.1 2.6 2 0 0 2 2 2 2 Vacuolar protein sorting protein 36 Vps36 SHMT PF00464.19 EFC43488.1 - 1.8e-176 586.7 0.0 2.2e-176 586.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EFC43488.1 - 1e-05 24.9 0.0 0.00025 20.3 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFC43488.1 - 6.3e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SelA PF03841.13 EFC43488.1 - 0.096 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 L-seryl-tRNA selenium transferase Epimerase PF01370.21 EFC43489.1 - 6.4e-15 55.3 0.0 1e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC43489.1 - 2.9e-13 49.5 0.0 5.1e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC43489.1 - 2.1e-11 43.5 0.0 3.1e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EFC43489.1 - 3e-06 27.3 0.0 0.0035 17.2 0.0 2.7 2 1 0 2 2 2 2 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 EFC43489.1 - 1.4e-05 24.7 0.1 2.6e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 EFC43489.1 - 1.5e-05 24.6 0.0 6.5e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 EFC43489.1 - 0.0058 15.8 0.0 0.01 15.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Complex1_LYR PF05347.15 EFC43490.1 - 0.0012 18.8 1.9 1.4 9.0 0.1 2.6 1 1 1 2 2 2 2 Complex 1 protein (LYR family) DUF4718 PF15842.5 EFC43491.1 - 0.3 10.9 5.1 0.38 10.5 3.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) RCC1 PF00415.18 EFC43493.1 - 6.6e-12 45.9 0.6 0.28 11.8 0.0 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43493.1 - 2.2e-11 43.2 10.0 0.00048 19.8 0.4 5.6 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Fibrinogen_C PF00147.18 EFC43495.1 - 0.0015 18.4 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain LigB PF02900.18 EFC43496.1 - 1.9e-38 132.1 0.0 2.3e-38 131.8 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DUF1959 PF09218.10 EFC43496.1 - 0.029 14.5 0.0 14 5.9 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1959) Csm1_B PF18211.1 EFC43496.1 - 0.089 12.6 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Csm1 subunit domain B Mersacidin PF16934.5 EFC43496.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Two-component Enterococcus faecalis cytolysin (EFC) EGF_2 PF07974.13 EFC43497.1 - 6.5e-08 32.8 76.5 0.00062 20.1 9.5 6.1 6 0 0 6 6 6 5 EGF-like domain DUF4889 PF16230.5 EFC43497.1 - 0.72 10.1 2.2 3.2 8.0 2.2 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) DUF3139 PF11337.8 EFC43498.1 - 0.076 13.7 0.2 0.076 13.7 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Sar8_2 PF03058.14 EFC43498.1 - 0.1 13.2 0.5 0.14 12.7 0.5 1.4 1 1 0 1 1 1 0 Sar8.2 family LPAM_1 PF08139.12 EFC43498.1 - 0.31 11.6 2.9 0.92 10.1 2.7 2.0 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site O-antigen_lig PF13425.6 EFC43498.1 - 0.6 8.8 2.3 0.66 8.7 2.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RhoGAP PF00620.27 EFC43499.1 - 3.3e-25 88.7 0.0 7.2e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain BTB_2 PF02214.22 EFC43500.1 - 3.3e-14 53.0 1.2 4.8e-09 36.4 0.2 2.9 2 0 0 2 2 2 2 BTB/POZ domain COG2 PF06148.11 EFC43500.1 - 2.3 8.3 12.6 0.043 13.9 4.1 2.5 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 YabA PF06156.13 EFC43500.1 - 3 8.5 11.5 0.47 11.1 5.7 2.8 3 0 0 3 3 3 0 Initiation control protein YabA Guanylate_cyc PF00211.20 EFC43501.1 - 0.036 13.7 0.0 0.097 12.3 0.0 1.8 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain EVI2A PF05399.11 EFC43501.1 - 4.7 6.7 7.3 2.5 7.7 1.9 2.2 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) EGF_2 PF07974.13 EFC43502.1 - 1.3e-72 239.8 805.0 0.00049 20.4 11.6 53.7 56 0 0 56 56 56 45 EGF-like domain Stevor PF17410.2 EFC43502.1 - 0.0028 17.3 0.9 0.0066 16.0 0.9 1.5 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame DUF3850 PF12961.7 EFC43502.1 - 0.074 13.1 0.0 5.2 7.2 0.1 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3850) Phage_HK97_TLTM PF06120.11 EFC43502.1 - 0.13 11.5 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 Tail length tape measure protein RCC1_2 PF13540.6 EFC43503.1 - 1.7e-13 49.9 5.4 0.0014 18.4 0.0 6.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC43503.1 - 7.5e-06 25.8 10.5 0.12 12.4 0.1 5.3 6 0 0 6 6 6 3 Kelch motif RCC1 PF00415.18 EFC43503.1 - 0.00014 22.4 10.5 2 9.1 0.0 6.6 6 2 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC43504.1 - 5.1e-58 193.5 12.7 1.8e-10 41.3 0.0 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43504.1 - 1.1e-56 187.6 18.7 5.3e-09 35.6 0.0 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC43504.1 - 0.022 15.0 1.7 11 6.4 0.5 4.0 3 1 0 3 3 3 0 Putative heavy-metal chelation Peptidase_S31 PF05578.12 EFC43504.1 - 0.11 12.0 0.2 0.22 11.0 0.2 1.5 1 0 0 1 1 1 0 Pestivirus NS3 polyprotein peptidase S31 FTP PF07504.13 EFC43504.1 - 2.9 7.8 5.2 40 4.1 0.1 3.6 5 0 0 5 5 5 0 Fungalysin/Thermolysin Propeptide Motif LAGLIDADG_3 PF14528.6 EFC43505.1 - 0.038 14.3 0.7 0.06 13.7 0.1 1.7 2 0 0 2 2 2 0 LAGLIDADG-like domain RCC1 PF00415.18 EFC43507.1 - 1.3e-40 137.8 3.9 3.5e-07 30.7 0.1 6.0 6 0 0 6 6 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43507.1 - 7.4e-23 79.8 15.1 4e-08 32.9 0.3 6.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC43507.1 - 1.7e-12 47.0 21.8 1e-05 25.4 0.1 5.6 5 0 0 5 5 5 4 Kelch motif Fibrinogen_C PF00147.18 EFC43507.1 - 9.4e-08 32.1 0.0 6.2e-07 29.4 0.0 2.2 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain Kelch_2 PF07646.15 EFC43507.1 - 3.5e-06 26.8 2.4 0.31 11.1 0.1 5.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFC43507.1 - 0.0002 20.9 13.9 1.3 8.7 0.1 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EFC43507.1 - 0.00074 19.5 5.5 10 6.2 0.1 5.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC43507.1 - 0.00084 19.6 11.7 1.1 9.6 0.0 5.6 5 0 0 5 5 5 1 Galactose oxidase, central domain EGF_Tenascin PF18720.1 EFC43507.1 - 0.001 19.1 20.0 0.0077 16.3 5.6 2.6 2 0 0 2 2 2 2 Tenascin EGF domain Kelch_6 PF13964.6 EFC43507.1 - 0.0034 17.6 26.5 0.73 10.2 0.2 6.9 7 1 1 8 8 8 3 Kelch motif EGF_2 PF07974.13 EFC43507.1 - 0.0053 17.1 31.4 0.026 14.9 8.6 2.9 3 0 0 3 3 2 2 EGF-like domain Pkinase PF00069.25 EFC43508.1 - 4.1e-77 259.1 0.0 4.7e-77 258.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43508.1 - 9.3e-29 100.5 0.0 1.5e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC43508.1 - 0.021 14.2 0.0 0.031 13.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SwrA PF17423.2 EFC43508.1 - 0.11 12.4 1.1 0.37 10.8 1.1 1.9 1 1 0 1 1 1 0 Swarming motility protein Ank_4 PF13637.6 EFC43509.1 - 2.5e-06 27.9 0.7 0.051 14.2 0.1 4.0 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC43509.1 - 0.00024 21.3 0.3 1.2 9.9 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFC43509.1 - 0.00039 20.7 0.0 0.44 10.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC43509.1 - 0.0011 19.6 0.1 0.11 13.1 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) SAM_1 PF00536.30 EFC43510.1 - 2.4e-05 24.7 0.1 4.7e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC43510.1 - 0.0002 21.4 0.2 0.00059 19.9 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 EFC43510.1 - 0.001 18.8 0.0 0.0035 17.1 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Peptidase_C97 PF05903.14 EFC43510.1 - 0.066 13.0 0.4 0.42 10.4 0.1 2.2 2 0 0 2 2 2 0 PPPDE putative peptidase domain RCC1 PF00415.18 EFC43511.1 - 1.4e-46 156.9 6.5 8.8e-11 42.3 0.1 5.5 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43511.1 - 3.5e-39 131.8 16.5 1e-09 37.9 1.2 6.6 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC43511.1 - 4.4e-07 29.7 3.0 0.011 15.7 0.1 4.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFC43511.1 - 1.9 8.2 5.0 12 5.6 0.2 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 EFC43511.1 - 4 7.9 14.7 9.9 6.6 0.0 5.5 7 0 0 7 7 7 0 Kelch motif Questin_oxidase PF14027.6 EFC43512.1 - 2.7e-63 214.6 1.0 3.2e-63 214.3 1.0 1.1 1 0 0 1 1 1 1 Questin oxidase-like PAH PF02671.21 EFC43512.1 - 2.4 8.3 6.6 0.86 9.8 0.5 3.3 3 1 0 3 3 3 0 Paired amphipathic helix repeat SpoIIE PF07228.12 EFC43513.1 - 2.3e-16 60.3 0.0 6.3e-16 58.9 0.0 1.7 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EFC43513.1 - 0.00019 21.1 0.1 0.13 11.8 0.0 2.6 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 EFC43513.1 - 0.0014 18.3 0.3 0.01 15.5 0.0 2.5 2 1 0 2 2 2 1 Protein phosphatase 2C zf-B_box PF00643.24 EFC43514.1 - 0.032 14.4 2.1 0.032 14.4 2.1 2.0 2 0 0 2 2 2 0 B-box zinc finger FYVE PF01363.21 EFC43514.1 - 0.097 12.8 7.6 0.18 12.0 7.6 1.6 1 1 0 1 1 1 0 FYVE zinc finger zf-AN1 PF01428.16 EFC43514.1 - 0.29 11.3 9.1 1.1 9.5 4.8 2.3 1 1 1 2 2 2 0 AN1-like Zinc finger IBR PF01485.21 EFC43514.1 - 0.71 10.1 11.1 0.13 12.6 6.5 1.9 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Zn-ribbon_8 PF09723.10 EFC43514.1 - 2.8 8.1 9.2 1e+02 3.2 5.0 2.6 1 1 1 2 2 2 0 Zinc ribbon domain HypA PF01155.19 EFC43514.1 - 8.2 6.5 7.6 43 4.2 7.6 1.9 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CLU PF13236.6 EFC43515.1 - 1.9e-82 276.4 0.0 5.1e-82 275.0 0.0 1.8 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 EFC43515.1 - 3.2e-47 160.8 0.3 3.2e-47 160.8 0.3 3.5 3 0 0 3 3 3 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 EFC43515.1 - 2.7e-21 75.6 0.5 2.9e-12 46.7 0.5 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC43515.1 - 1.3e-14 53.5 0.0 4.1e-07 29.7 0.2 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat CLU_N PF15044.6 EFC43515.1 - 8.9e-13 48.4 2.6 1.2e-12 48.0 0.1 2.7 3 0 0 3 3 2 1 Mitochondrial function, CLU-N-term TPR_8 PF13181.6 EFC43515.1 - 9.1e-07 28.6 0.7 0.025 14.8 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat ubiquitin PF00240.23 EFC43515.1 - 2.7e-06 27.0 0.2 8.4e-06 25.5 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin family TPR_1 PF00515.28 EFC43515.1 - 3.3e-06 26.7 0.5 0.23 11.4 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF727 PF05303.12 EFC43515.1 - 9.7e-05 22.4 0.0 0.00036 20.5 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_2 PF07719.17 EFC43515.1 - 0.00019 21.3 2.2 1.6 9.0 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC43515.1 - 0.0017 18.2 0.6 0.33 11.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC43515.1 - 0.0094 15.4 0.4 0.041 13.2 0.1 2.0 2 1 0 2 2 2 1 MalT-like TPR region DUF2225 PF09986.9 EFC43515.1 - 0.011 15.4 0.2 0.041 13.6 0.2 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 EFC43515.1 - 0.097 13.4 0.3 1.6 9.5 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC5 PF12862.7 EFC43515.1 - 0.18 11.9 0.8 0.49 10.5 0.1 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Peptidase_S49_N PF08496.10 EFC43515.1 - 6 6.9 9.2 0.26 11.3 1.5 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal F-box_5 PF18511.1 EFC43516.1 - 0.00042 19.8 0.0 0.00099 18.6 0.0 1.6 1 0 0 1 1 1 1 F-box F-box-like PF12937.7 EFC43516.1 - 0.027 14.4 0.0 0.07 13.0 0.0 1.7 1 0 0 1 1 1 0 F-box-like BTB_2 PF02214.22 EFC43517.1 - 3.9e-12 46.3 0.4 2e-06 28.0 0.1 3.5 3 0 0 3 3 3 2 BTB/POZ domain BTB PF00651.31 EFC43517.1 - 0.047 13.9 0.1 0.22 11.7 0.0 2.2 2 0 0 2 2 2 0 BTB/POZ domain EDS1_EP PF18117.1 EFC43517.1 - 0.42 11.1 7.0 0.63 10.5 1.1 3.2 2 0 0 2 2 2 0 Enhanced disease susceptibility 1 protein EP domain CAC1F_C PF16885.5 EFC43518.1 - 0.41 10.3 18.6 0.24 11.0 16.9 1.4 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Pox_Ag35 PF03286.14 EFC43518.1 - 6.5 6.5 28.8 2.9 7.7 18.8 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF4690 PF15756.5 EFC43519.1 - 0.015 15.9 1.7 0.03 14.9 0.4 2.1 2 0 0 2 2 2 0 Small Novel Rich in Cartilage REJ PF02010.15 EFC43520.1 - 1.4e-31 109.8 4.7 1.4e-31 109.8 4.7 3.8 3 1 1 4 4 4 2 REJ domain EGF_2 PF07974.13 EFC43520.1 - 4.5e-17 62.1 140.0 4.4e-05 23.7 10.2 10.4 9 1 1 10 10 10 7 EGF-like domain DSL PF01414.19 EFC43520.1 - 0.00059 20.0 15.8 0.00059 20.0 15.8 6.8 4 1 2 6 6 6 1 Delta serrate ligand RII_binding_1 PF10522.9 EFC43520.1 - 0.13 12.5 0.3 0.63 10.4 0.3 2.3 1 0 0 1 1 1 0 RII binding domain PNTB_4TM PF12769.7 EFC43520.1 - 4.1 7.9 7.3 39 4.8 0.1 4.0 2 1 1 3 3 3 0 4TM region of pyridine nucleotide transhydrogenase, mitoch Sulf_transp PF04143.14 EFC43521.1 - 9.1e-05 22.2 0.2 0.00012 21.7 0.2 1.1 1 0 0 1 1 1 1 Sulphur transport DUF898 PF05987.13 EFC43521.1 - 0.047 12.7 1.2 0.068 12.2 0.2 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) AgrB PF04647.15 EFC43521.1 - 0.12 11.6 10.4 0.051 12.9 5.9 2.0 1 1 1 2 2 2 0 Accessory gene regulator B DUF373 PF04123.13 EFC43521.1 - 0.26 10.7 3.1 0.3 10.5 3.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Rhabdo_glycop PF00974.18 EFC43521.1 - 3.9 5.8 4.9 0.83 8.0 0.2 1.9 1 1 1 2 2 2 0 Rhabdovirus spike glycoprotein adh_short PF00106.25 EFC43522.1 - 1.8e-20 73.2 0.1 3.4e-18 65.8 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43522.1 - 1.2e-14 54.5 0.0 5.7e-14 52.2 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43522.1 - 0.00072 19.5 0.0 0.001 19.0 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFC43522.1 - 0.003 17.0 0.1 0.01 15.2 0.1 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC43522.1 - 0.01 15.3 0.1 0.047 13.1 0.1 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TFIIB PF00382.19 EFC43522.1 - 0.027 14.5 0.1 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 Transcription factor TFIIB repeat Csm1_B PF18211.1 EFC43522.1 - 0.068 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Csm1 subunit domain B EGF_2 PF07974.13 EFC43523.1 - 1.3e-09 38.2 68.0 6e-05 23.3 10.5 4.9 5 0 0 5 5 5 4 EGF-like domain RGS PF00615.19 EFC43523.1 - 1.1e-05 25.7 0.6 1.1e-05 25.7 0.6 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF285 PF03382.14 EFC43523.1 - 0.26 11.1 5.0 0.11 12.2 1.9 2.0 2 0 0 2 2 2 0 Mycoplasma protein of unknown function, DUF285 Chi-conotoxin PF16981.5 EFC43524.1 - 2.3 8.5 5.9 1.1 9.5 0.1 2.9 3 0 0 3 3 3 0 chi-Conotoxin or t superfamily UPF0193 PF05250.11 EFC43525.1 - 1.8e-23 83.5 9.0 2.2e-23 83.2 9.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0193) Pkinase PF00069.25 EFC43526.1 - 0.0014 18.1 0.0 0.0025 17.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkip-1 PF06878.11 EFC43526.1 - 0.031 14.4 0.4 0.042 13.9 0.4 1.1 1 0 0 1 1 1 0 Pkip-1 protein Pkinase_Tyr PF07714.17 EFC43526.1 - 0.067 12.5 0.0 0.088 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase 14-3-3 PF00244.20 EFC43527.1 - 5e-41 140.6 1.2 5.4e-41 140.5 1.2 1.0 1 0 0 1 1 1 1 14-3-3 protein RRF PF01765.19 EFC43527.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosome recycling factor Ran_BP1 PF00638.18 EFC43528.1 - 8.5e-48 161.7 1.6 1.2e-47 161.2 1.6 1.2 1 0 0 1 1 1 1 RanBP1 domain Ras PF00071.22 EFC43530.1 - 4.1e-30 104.5 0.0 7.7e-30 103.6 0.0 1.4 1 0 0 1 1 1 1 Ras family Kelch_5 PF13854.6 EFC43530.1 - 2.2e-26 91.4 2.5 5.6e-07 29.4 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 EFC43530.1 - 1.2e-22 79.6 3.3 7.1e-05 22.7 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC43530.1 - 3e-20 72.0 0.0 0.012 15.9 0.0 5.4 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC43530.1 - 2.5e-16 59.3 1.9 0.015 15.6 0.0 5.1 5 0 0 5 5 4 4 Kelch motif Kelch_1 PF01344.25 EFC43530.1 - 1.4e-14 53.3 0.4 0.0098 15.5 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFC43530.1 - 3.6e-11 42.6 2.7 0.024 14.6 0.0 5.1 5 0 0 5 5 5 3 Kelch motif Roc PF08477.13 EFC43530.1 - 7.3e-09 35.9 0.0 1.6e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43530.1 - 0.023 14.2 0.0 0.042 13.3 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC43530.1 - 0.051 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box PF00646.33 EFC43530.1 - 0.3 11.0 1.7 0.55 10.2 0.1 2.4 3 0 0 3 3 3 0 F-box domain Pkinase PF00069.25 EFC43531.1 - 1.5e-45 155.7 1.7 2.2e-45 155.1 1.7 1.3 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC43531.1 - 1.9e-42 141.2 0.9 2.7e-06 27.1 0.0 10.8 10 0 0 10 10 10 8 NHL repeat Pkinase_Tyr PF07714.17 EFC43531.1 - 2.3e-28 99.2 0.3 3.3e-28 98.7 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SGL PF08450.12 EFC43531.1 - 2.9e-09 36.9 7.9 0.1 12.1 0.1 5.3 4 2 1 6 6 6 4 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC43531.1 - 1.5e-08 34.9 51.6 0.0015 18.9 8.0 3.6 3 0 0 3 3 3 3 EGF-like domain Arylesterase PF01731.20 EFC43531.1 - 7.6e-05 22.8 7.4 1.1 9.5 0.0 6.9 5 3 3 9 9 8 2 Arylesterase Pkinase_fungal PF17667.1 EFC43531.1 - 0.00064 18.6 0.1 0.0012 17.7 0.1 1.5 1 1 0 1 1 1 1 Fungal protein kinase Str_synth PF03088.16 EFC43531.1 - 0.0026 17.8 3.5 4 7.6 0.0 6.5 8 2 1 9 9 9 1 Strictosidine synthase EGF PF00008.27 EFC43531.1 - 0.015 15.6 36.8 0.07 13.4 6.2 3.7 3 0 0 3 3 3 0 EGF-like domain Phytase-like PF13449.6 EFC43531.1 - 0.048 13.6 0.0 12 5.7 0.0 3.9 3 2 0 3 3 3 0 Esterase-like activity of phytase EB PF01683.18 EFC43531.1 - 0.12 12.6 34.9 0.15 12.3 4.7 3.4 3 0 0 3 3 3 0 EB module LRR_4 PF12799.7 EFC43532.1 - 0.046 14.2 20.8 0.8 10.2 0.7 6.9 5 2 3 8 8 8 0 Leucine Rich repeats (2 copies) Sporozoite_P67 PF05642.11 EFC43533.1 - 0.15 10.1 0.6 0.22 9.6 0.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4611 PF15387.6 EFC43533.1 - 1.1 9.5 7.2 3.3 8.0 7.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 EFC43533.1 - 2.9 8.3 12.0 0.27 11.6 6.6 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Thioredoxin PF00085.20 EFC43534.1 - 7.5e-18 64.4 0.1 8.1e-18 64.3 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 EFC43534.1 - 0.00012 21.9 0.0 0.00015 21.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Glutaredoxin PF00462.24 EFC43534.1 - 0.0039 17.4 0.1 0.0077 16.4 0.1 1.5 1 0 0 1 1 1 1 Glutaredoxin OST3_OST6 PF04756.13 EFC43534.1 - 0.0048 16.3 0.1 0.006 16.0 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFC43534.1 - 0.0067 16.9 0.1 0.0092 16.4 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFC43534.1 - 0.017 15.5 0.1 0.045 14.1 0.1 1.7 1 1 0 1 1 1 0 Thioredoxin-like Redoxin PF08534.10 EFC43534.1 - 0.022 14.5 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.6 EFC43534.1 - 0.041 14.1 0.0 0.06 13.5 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 EFC43534.1 - 0.09 12.7 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family CLTH PF10607.9 EFC43535.1 - 3.6e-36 124.3 0.5 8.8e-36 123.0 0.1 1.8 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Zwint PF15556.6 EFC43535.1 - 0.018 14.5 2.0 0.033 13.7 2.0 1.4 1 0 0 1 1 1 0 ZW10 interactor Fe_dep_repr_C PF02742.15 EFC43535.1 - 0.081 13.0 0.0 0.37 10.9 0.0 2.1 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain FKS1_dom1 PF14288.6 EFC43535.1 - 0.09 13.1 0.2 0.21 11.9 0.2 1.6 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 YfcL PF08891.11 EFC43535.1 - 0.19 12.1 1.4 0.35 11.2 0.3 2.1 2 0 0 2 2 2 0 YfcL protein Ribosomal_L32e PF01655.18 EFC43536.1 - 3.4e-33 114.3 0.3 4e-33 114.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Ependymin PF00811.18 EFC43537.1 - 0.22 11.8 2.9 0.67 10.2 2.9 1.8 1 1 0 1 1 1 0 Ependymin TRAM_LAG1_CLN8 PF03798.16 EFC43538.1 - 1.8e-18 67.0 24.2 2.6e-18 66.5 24.2 1.2 1 0 0 1 1 1 1 TLC domain YtxH PF12732.7 EFC43539.1 - 2.3e-11 44.1 40.0 0.00022 21.7 6.7 4.3 1 1 2 3 3 3 2 YtxH-like protein Apolipoprotein PF01442.18 EFC43539.1 - 1.5e-09 38.1 12.1 2.1e-05 24.5 9.3 2.0 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain LEA_4 PF02987.16 EFC43539.1 - 4.7e-09 36.2 60.8 8e-05 22.6 18.2 5.7 1 1 6 7 7 7 4 Late embryogenesis abundant protein DUF883 PF05957.13 EFC43539.1 - 2.9e-07 31.0 17.1 0.012 16.2 3.1 3.9 1 1 3 4 4 4 4 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 EFC43539.1 - 7.3e-06 26.1 18.9 0.00043 20.4 7.9 2.2 1 1 1 2 2 2 2 Apolipophorin-III precursor (apoLp-III) RPA_interact_N PF14766.6 EFC43539.1 - 0.00032 20.3 1.7 0.5 10.0 0.1 3.2 3 1 0 3 3 3 2 Replication protein A interacting N-terminal Prominin PF05478.11 EFC43539.1 - 0.003 15.6 10.6 0.13 10.2 3.2 2.0 1 1 1 2 2 2 2 Prominin PhaP_Bmeg PF09602.10 EFC43539.1 - 0.02 14.9 15.9 0.41 10.6 4.1 2.3 1 1 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Zeta_toxin PF06414.12 EFC43539.1 - 0.027 13.7 6.5 0.37 10.0 0.9 2.3 1 1 0 2 2 2 0 Zeta toxin ApoO PF09769.9 EFC43539.1 - 0.03 14.3 3.8 2.4 8.1 0.9 3.2 1 1 1 2 2 2 0 Apolipoprotein O WXG100 PF06013.12 EFC43539.1 - 0.036 14.3 5.5 0.55 10.5 0.3 2.9 1 1 2 3 3 3 0 Proteins of 100 residues with WXG DUF2746 PF10874.8 EFC43539.1 - 0.04 14.3 10.9 0.12 12.8 0.7 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2746) CdvA PF18822.1 EFC43539.1 - 0.058 13.2 21.9 0.065 13.1 3.3 3.9 1 1 3 4 4 4 0 CdvA-like coiled-coil domain ATP-synt_B PF00430.18 EFC43539.1 - 0.34 11.0 10.8 6.1 6.9 4.2 2.7 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) zf-CRD PF17979.1 EFC43539.1 - 0.61 10.2 3.4 6.4 6.9 0.2 2.2 1 1 0 2 2 2 0 Cysteine rich domain with multizinc binding regions QIL1 PF15884.5 EFC43539.1 - 0.88 10.2 3.9 45 4.7 3.9 3.0 1 1 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 Mit_KHE1 PF10173.9 EFC43539.1 - 1.1 9.3 12.5 5.2 7.1 2.6 2.5 1 1 1 2 2 2 0 Mitochondrial K+-H+ exchange-related DUF1178 PF06676.11 EFC43539.1 - 2.9 8.3 8.3 9.6 6.6 8.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) Baculo_p24 PF05073.12 EFC43539.1 - 3.1 7.6 10.8 4.3 7.1 3.7 2.1 1 1 1 2 2 2 0 Baculovirus P24 capsid protein ZYG-11_interact PF05884.12 EFC43539.1 - 3.3 7.1 5.6 23 4.3 5.4 2.0 1 1 0 1 1 1 0 Interactor of ZYG-11 DUF2203 PF09969.9 EFC43539.1 - 5.3 7.8 11.6 1.1e+03 0.3 11.6 2.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF2884 PF11101.8 EFC43539.1 - 5.4 6.5 14.2 4.3 6.8 0.8 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF2884) Syntaxin-6_N PF09177.11 EFC43539.1 - 6.5 7.4 14.0 3.9e+03 -1.5 14.0 3.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Atg14 PF10186.9 EFC43539.1 - 6.7 5.7 10.5 32 3.5 10.1 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_S6e PF01092.19 EFC43541.1 - 6.8e-27 93.9 0.1 2.8e-26 91.9 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e ATP-grasp_5 PF13549.6 EFC43541.1 - 0.048 13.1 0.2 0.073 12.5 0.2 1.3 1 0 0 1 1 1 0 ATP-grasp domain Myb_DNA-bind_6 PF13921.6 EFC43541.1 - 0.13 12.5 0.4 0.26 11.6 0.4 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Csm2_III-A PF03750.13 EFC43542.1 - 0.61 10.9 3.7 0.38 11.6 0.3 2.2 2 1 0 2 2 2 0 Csm2 Type III-A Baculo_PEP_C PF04513.12 EFC43542.1 - 3.5 7.6 6.5 6.4 6.8 3.7 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SAM_1 PF00536.30 EFC43543.1 - 1.9e-05 25.0 1.3 0.11 13.0 0.4 4.3 3 1 0 3 3 3 2 SAM domain (Sterile alpha motif) Peptidase_C97 PF05903.14 EFC43543.1 - 0.0048 16.7 0.0 0.01 15.7 0.0 1.6 1 0 0 1 1 1 1 PPPDE putative peptidase domain SAM_2 PF07647.17 EFC43543.1 - 0.0082 16.2 1.2 1.4 9.1 0.1 3.9 5 0 0 5 5 5 1 SAM domain (Sterile alpha motif) AKAP28 PF14469.6 EFC43543.1 - 0.084 12.6 0.2 0.17 11.7 0.2 1.4 1 0 0 1 1 1 0 28 kDa A-kinase anchor Sacchrp_dh_C PF16653.5 EFC43544.1 - 0.026 14.6 0.2 0.095 12.8 0.2 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain PRP1_N PF06424.12 EFC43544.1 - 2.3 8.6 13.1 5.9 7.3 8.5 3.5 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal Spc7 PF08317.11 EFC43544.1 - 4.3 6.1 30.5 0.27 10.1 3.7 3.1 4 0 0 4 4 4 0 Spc7 kinetochore protein PADR1 PF08063.12 EFC43545.1 - 0.0027 17.4 0.9 0.41 10.5 0.2 2.0 2 0 0 2 2 2 2 PADR1 (NUC008) domain UPF0203 PF05254.12 EFC43545.1 - 0.0038 17.4 2.6 0.26 11.6 0.2 2.0 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0203) Ndufs5 PF10200.9 EFC43545.1 - 0.01 16.1 0.4 0.014 15.6 0.4 1.3 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa COX17 PF05051.13 EFC43545.1 - 0.012 16.0 1.9 0.19 12.1 1.6 2.0 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) COX6B PF02297.17 EFC43545.1 - 0.076 13.3 3.3 0.49 10.7 0.4 2.0 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb CHCH PF06747.13 EFC43545.1 - 0.16 12.1 3.0 0.92 9.7 0.2 2.3 1 1 2 3 3 3 0 CHCH domain Metallophos PF00149.28 EFC43546.1 - 4.6e-13 50.1 4.5 1.1e-12 48.9 4.5 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase BRCT PF00533.26 EFC43547.1 - 3.1e-08 33.9 0.1 1.1e-07 32.1 0.1 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC43547.1 - 3.4e-07 30.6 0.0 8.9e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain ATP_bind_3 PF01171.20 EFC43548.1 - 1.7e-17 63.7 0.0 3.1e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 EFC43548.1 - 3e-16 58.6 1.3 3e-16 58.6 1.3 2.7 2 0 0 2 2 2 1 Zinc-ribbon PAPS_reduct PF01507.19 EFC43548.1 - 0.029 14.4 0.0 0.045 13.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family tRNA_Me_trans PF03054.16 EFC43548.1 - 0.059 12.1 0.0 0.059 12.1 0.0 1.8 2 0 0 2 2 2 0 tRNA methyl transferase HTH_AraC PF00165.23 EFC43548.1 - 0.089 12.9 0.3 3.4 7.9 0.0 3.2 3 0 0 3 3 3 0 Bacterial regulatory helix-turn-helix proteins, AraC family PuR_N PF09182.10 EFC43548.1 - 0.12 12.3 0.1 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal zf-UBR PF02207.20 EFC43548.1 - 0.24 11.6 3.2 4.2 7.6 0.2 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) TF_Zn_Ribbon PF08271.12 EFC43548.1 - 2.1 7.9 10.3 0.14 11.7 0.9 3.0 3 0 0 3 3 3 0 TFIIB zinc-binding Aminotran_5 PF00266.19 EFC43549.1 - 1.5e-32 113.0 0.0 2.7e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFC43549.1 - 0.00019 20.7 0.0 0.00053 19.3 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II DUF5344 PF17279.2 EFC43549.1 - 0.02 15.5 0.3 0.1 13.2 0.7 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5344) SHMT PF00464.19 EFC43549.1 - 0.049 12.2 0.0 0.086 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine hydroxymethyltransferase PRK PF00485.18 EFC43549.1 - 0.091 12.5 0.0 0.33 10.7 0.0 1.8 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Elf4 PF07011.11 EFC43549.1 - 0.28 11.1 1.5 26 4.8 0.0 3.1 3 0 0 3 3 3 0 Early Flowering 4 domain Pkinase PF00069.25 EFC43550.1 - 1.4e-39 136.0 1.1 1.6e-39 135.9 1.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43550.1 - 4.6e-26 91.7 0.1 5.6e-26 91.4 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43550.1 - 1.9e-05 23.6 0.1 3.7e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC43550.1 - 0.0021 17.1 0.7 0.003 16.6 0.7 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC43550.1 - 0.028 13.8 0.1 0.045 13.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC43550.1 - 0.041 13.8 0.0 0.067 13.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Beta-lactamase PF00144.24 EFC43551.1 - 4.1e-42 144.6 0.0 9.4e-28 97.4 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase DUF2608 PF11019.8 EFC43551.1 - 0.076 12.5 0.1 0.23 10.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) DUF1731 PF08338.11 EFC43552.1 - 2.4e-10 40.1 0.0 4.1e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 EFC43552.1 - 0.0017 17.9 0.0 0.0094 15.4 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SOR_SNZ PF01680.17 EFC43553.1 - 3.9e-13 49.7 0.4 7.3e-13 48.8 0.2 1.5 1 1 1 2 2 2 1 SOR/SNZ family zf-CCHC_5 PF14787.6 EFC43554.1 - 1.9e-09 37.1 7.8 1.7e-05 24.4 1.0 2.3 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger HNH_3 PF13392.6 EFC43554.1 - 1.5e-05 24.7 0.2 2.9e-05 23.7 0.2 1.5 1 0 0 1 1 1 1 HNH endonuclease zf-CCHC PF00098.23 EFC43554.1 - 0.18 11.9 13.7 0.14 12.2 2.4 2.3 2 0 0 2 2 2 0 Zinc knuckle Ribosomal_L37e PF01907.19 EFC43554.1 - 0.5 10.6 12.3 1.9 8.7 3.6 2.5 2 0 0 2 2 2 0 Ribosomal protein L37e IBR PF01485.21 EFC43554.1 - 0.77 10.0 5.8 6.2 7.1 1.0 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain zf-CCHC_4 PF14392.6 EFC43554.1 - 8.7 6.2 12.7 4.5 7.1 3.2 2.3 2 0 0 2 2 2 0 Zinc knuckle CN_hydrolase PF00795.22 EFC43555.1 - 1.7e-08 34.2 0.0 6e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase DUF4116 PF13475.6 EFC43556.1 - 1.5e-58 194.3 21.4 2.2e-14 52.9 0.0 9.7 5 3 5 11 11 11 10 Domain of unknown function (DUF4116) Nsp1 PF11501.8 EFC43556.1 - 0.08 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Non structural protein Nsp1 Fis1_TPR_C PF14853.6 EFC43557.1 - 6e-10 39.0 0.2 1.4e-09 37.9 0.2 1.7 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 EFC43557.1 - 3.8e-05 23.2 0.0 7.5e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat Mg296 PF09644.10 EFC43557.1 - 0.0068 16.5 1.1 0.014 15.6 1.1 1.5 1 0 0 1 1 1 1 Mg296 protein AF2331-like PF14556.6 EFC43557.1 - 0.082 13.5 0.4 0.19 12.3 0.2 1.7 1 1 0 1 1 1 0 AF2331-like DUF4834 PF16118.5 EFC43557.1 - 0.11 13.5 2.2 0.26 12.2 2.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Kinesin PF00225.23 EFC43561.1 - 9.9e-30 103.6 4.5 1.3e-26 93.4 0.3 3.3 2 2 0 2 2 2 2 Kinesin motor domain zf-C3HC4_3 PF13920.6 EFC43563.1 - 1.3e-17 63.4 7.7 2.1e-17 62.7 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC43563.1 - 9.6e-11 41.4 7.6 9.6e-11 41.4 7.6 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 EFC43563.1 - 1.2e-07 32.0 7.2 2.4e-07 31.0 7.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFC43563.1 - 6.4e-06 26.0 7.6 1.4e-05 25.0 7.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFC43563.1 - 0.00023 20.9 8.7 0.00047 19.9 8.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC43563.1 - 0.0049 16.9 1.3 0.0049 16.9 1.3 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 EFC43563.1 - 0.044 13.6 5.0 0.091 12.6 5.0 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-P11 PF03854.14 EFC43563.1 - 0.092 12.4 6.5 0.053 13.2 4.1 1.9 2 0 0 2 2 2 0 P-11 zinc finger DZR PF12773.7 EFC43563.1 - 2.2 8.4 7.8 5.9 7.0 7.8 1.7 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_4 PF15227.6 EFC43563.1 - 2.5 8.3 6.4 7.6 6.8 6.4 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING AFOR_C PF01314.18 EFC43564.1 - 0.018 14.1 1.3 0.026 13.5 1.3 1.2 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 Apt1 PF10351.9 EFC43564.1 - 0.74 8.6 10.3 1.1 8.0 10.3 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain NPR3 PF03666.13 EFC43564.1 - 2.2 7.0 9.1 3.7 6.2 9.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Hid1 PF12722.7 EFC43564.1 - 7 4.6 7.8 9.7 4.2 7.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4614 PF15391.6 EFC43564.1 - 8.6 6.3 16.4 0.21 11.5 9.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) CcmB PF03379.13 EFC43565.1 - 0.039 13.4 0.7 0.062 12.8 0.7 1.2 1 0 0 1 1 1 0 CcmB protein DUF3611 PF12263.8 EFC43565.1 - 0.28 11.1 3.6 0.087 12.7 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) COG4 PF08318.12 EFC43566.1 - 0.03 13.4 4.0 0.072 12.1 4.0 1.6 1 0 0 1 1 1 0 COG4 transport protein Guanylate_cyc PF00211.20 EFC43566.1 - 0.057 13.0 0.2 0.13 11.8 0.2 1.6 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Actin PF00022.19 EFC43567.1 - 6e-145 482.9 0.0 2.4e-144 480.9 0.0 1.7 1 1 0 1 1 1 1 Actin DUF4116 PF13475.6 EFC43568.1 - 3.5e-66 218.7 3.4 1e-16 60.4 0.2 6.1 5 1 1 6 6 6 6 Domain of unknown function (DUF4116) PRA-CH PF01502.18 EFC43568.1 - 0.13 12.2 0.0 1.6 8.6 0.0 2.6 2 1 0 2 2 2 0 Phosphoribosyl-AMP cyclohydrolase Pkinase PF00069.25 EFC43569.1 - 6e-22 78.3 0.1 9.4e-22 77.6 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF4116 PF13475.6 EFC43569.1 - 6.2e-11 41.9 0.9 2.8e-10 39.8 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4116) Pkinase_Tyr PF07714.17 EFC43569.1 - 3.8e-10 39.5 0.2 2e-09 37.1 0.2 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43569.1 - 0.00012 21.0 0.4 0.00019 20.4 0.4 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC43569.1 - 0.19 11.6 0.1 0.46 10.4 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribosomal_S25 PF03297.15 EFC43571.1 - 2.1e-35 120.9 8.4 2.1e-35 120.9 8.4 1.6 1 1 1 2 2 2 1 S25 ribosomal protein MerR PF00376.23 EFC43571.1 - 0.0043 16.8 0.1 0.039 13.7 0.1 2.1 1 1 0 1 1 1 1 MerR family regulatory protein DDRGK PF09756.9 EFC43571.1 - 0.011 15.4 5.6 0.027 14.0 5.6 1.6 1 1 0 1 1 1 0 DDRGK domain HTH_DeoR PF08220.12 EFC43571.1 - 0.031 14.0 0.0 0.069 12.9 0.0 1.5 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain MerR_1 PF13411.6 EFC43571.1 - 0.085 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 MerR HTH family regulatory protein ADK PF00406.22 EFC43572.1 - 1.5e-19 70.6 0.0 1.1e-08 35.4 0.0 2.2 1 1 0 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 EFC43572.1 - 1.1e-12 48.6 0.0 4.3e-08 33.7 0.0 3.2 2 1 1 3 3 3 2 AAA domain ADK_lid PF05191.14 EFC43572.1 - 2.3e-10 40.2 0.1 4.4e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 EFC43572.1 - 0.0016 18.6 3.4 0.0053 16.9 3.4 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC43572.1 - 0.0058 17.2 0.3 0.049 14.2 0.1 2.7 2 1 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 EFC43572.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin FAM150 PF15129.6 EFC43572.1 - 0.019 15.1 0.0 0.044 13.9 0.0 1.6 1 0 0 1 1 1 0 FAM150 family ABC_tran PF00005.27 EFC43572.1 - 0.097 13.2 1.8 0.42 11.1 1.8 2.1 1 1 0 1 1 1 0 ABC transporter Shisa PF13908.6 EFC43572.1 - 1.9 8.7 16.6 1.6 8.9 4.1 2.2 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Ribosomal_L11_N PF03946.14 EFC43573.1 - 2.7e-22 78.4 0.5 4.7e-22 77.6 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 EFC43573.1 - 6.4e-16 58.6 1.0 1.4e-15 57.5 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain gerPA PF10676.9 EFC43573.1 - 0.029 14.6 0.1 0.052 13.8 0.1 1.4 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF TCTP PF00838.17 EFC43574.1 - 2.4e-42 145.1 10.4 2.7e-42 144.9 10.4 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Baculo_PEP_C PF04513.12 EFC43574.1 - 0.081 13.0 0.1 0.11 12.6 0.1 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus EF-hand_6 PF13405.6 EFC43574.1 - 0.17 11.9 1.9 0.41 10.7 0.1 2.6 3 0 0 3 3 3 0 EF-hand domain La PF05383.17 EFC43574.1 - 0.29 11.2 0.2 0.29 11.2 0.2 2.3 4 0 0 4 4 4 0 La domain AAA PF00004.29 EFC43575.1 - 1.4e-41 142.0 0.0 3e-41 140.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC43575.1 - 8.7e-13 47.9 0.0 2.1e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFC43575.1 - 6.9e-11 41.9 0.1 1.4e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 EFC43575.1 - 1.4e-07 32.1 0.1 7.4e-05 23.2 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 EFC43575.1 - 2.6e-06 27.5 0.0 3.9e-05 23.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFC43575.1 - 6e-06 26.1 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 EFC43575.1 - 6.1e-06 26.4 0.0 1.7e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFC43575.1 - 9.6e-05 22.7 0.0 0.018 15.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EFC43575.1 - 0.00028 20.1 0.1 0.00087 18.5 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TIP49 PF06068.13 EFC43575.1 - 0.00039 19.7 0.1 0.00078 18.7 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 EFC43575.1 - 0.001 18.7 0.0 0.0024 17.4 0.0 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 EFC43575.1 - 0.001 19.6 0.1 0.0064 17.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFC43575.1 - 0.0023 17.7 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Sigma54_activat PF00158.26 EFC43575.1 - 0.0024 17.6 0.0 0.011 15.4 0.0 2.1 1 1 1 2 2 2 1 Sigma-54 interaction domain RNA_helicase PF00910.22 EFC43575.1 - 0.0036 17.7 0.0 0.0091 16.4 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EFC43575.1 - 0.0045 16.4 0.0 0.0085 15.5 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EFC43575.1 - 0.0051 16.9 0.0 0.015 15.3 0.0 1.8 2 0 0 2 2 1 1 AAA domain ATPase PF06745.13 EFC43575.1 - 0.0069 15.8 0.7 0.085 12.2 0.0 2.5 3 0 0 3 3 2 1 KaiC AAA_3 PF07726.11 EFC43575.1 - 0.01 15.7 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 EFC43575.1 - 0.011 14.9 0.0 0.024 13.8 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Prot_ATP_OB_N PF17758.1 EFC43575.1 - 0.011 15.4 0.0 0.027 14.1 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain ABC_tran PF00005.27 EFC43575.1 - 0.013 16.0 0.3 0.21 12.1 0.0 2.7 3 0 0 3 3 2 0 ABC transporter Tektin PF03148.14 EFC43575.1 - 0.015 14.1 1.5 0.031 13.0 1.5 1.5 1 0 0 1 1 1 0 Tektin family AAA_11 PF13086.6 EFC43575.1 - 0.015 15.1 0.6 0.27 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 EFC43575.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF4200 PF13863.6 EFC43575.1 - 0.019 15.3 6.4 0.019 15.3 6.4 2.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4200) FapA PF03961.13 EFC43575.1 - 0.021 13.4 1.6 0.034 12.8 1.6 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PhoH PF02562.16 EFC43575.1 - 0.026 14.0 0.1 0.13 11.7 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EFC43575.1 - 0.027 14.2 0.6 0.069 12.9 0.1 2.0 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFC43575.1 - 0.036 14.2 0.0 0.092 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC43575.1 - 0.039 14.2 0.0 0.097 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFC43575.1 - 0.04 13.8 0.0 0.083 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 EFC43575.1 - 0.043 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 EFC43575.1 - 0.046 13.4 0.1 11 5.6 0.2 2.4 2 0 0 2 2 2 0 Thymidylate kinase Bac_DnaA PF00308.18 EFC43575.1 - 0.068 13.0 3.8 0.35 10.7 0.0 2.9 2 1 1 3 3 3 0 Bacterial dnaA protein AAA_25 PF13481.6 EFC43575.1 - 0.11 12.0 0.1 0.33 10.5 0.0 1.7 2 0 0 2 2 1 0 AAA domain ATPase_2 PF01637.18 EFC43575.1 - 0.17 11.7 2.6 0.32 10.9 0.0 2.6 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea Syntaxin-6_N PF09177.11 EFC43575.1 - 0.36 11.4 2.4 5.4 7.6 1.3 3.1 3 1 0 3 3 3 0 Syntaxin 6, N-terminal Phage_GP20 PF06810.11 EFC43575.1 - 3.1 7.6 10.3 8.8 6.1 1.8 3.2 4 0 0 4 4 3 0 Phage minor structural protein GP20 DivIC PF04977.15 EFC43575.1 - 3.9 7.3 9.2 0.39 10.5 3.4 2.3 3 0 0 3 3 2 0 Septum formation initiator DUF16 PF01519.16 EFC43575.1 - 8.1 7.0 7.9 3.8 8.1 2.8 2.6 3 0 0 3 3 2 0 Protein of unknown function DUF16 Ras PF00071.22 EFC43576.1 - 2.4e-19 69.5 0.0 2.8e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43576.1 - 0.0012 19.1 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Trypan_PARP PF05887.11 EFC43577.1 - 8.8e-06 25.7 92.8 1.8e+04 -34.8 92.8 3.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) HATPase_c PF02518.26 EFC43579.1 - 2.7e-14 53.6 0.3 2e-13 50.8 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC43579.1 - 1.1e-10 41.4 0.0 3.4e-10 39.8 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 EFC43579.1 - 5.2e-06 26.8 0.0 1.3e-05 25.5 0.0 1.7 1 1 0 1 1 1 1 GAF domain PAS_8 PF13188.7 EFC43579.1 - 0.0003 20.7 0.0 0.00091 19.2 0.0 1.8 1 0 0 1 1 1 1 PAS domain HATPase_c_3 PF13589.6 EFC43579.1 - 0.0015 18.4 0.0 0.0015 18.4 0.0 2.2 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF PF01590.26 EFC43579.1 - 0.0057 17.3 0.0 0.017 15.8 0.0 1.8 1 0 0 1 1 1 1 GAF domain SpoVT_C PF15714.5 EFC43579.1 - 0.053 13.6 0.3 3.3 7.8 0.0 3.6 4 0 0 4 4 4 0 Stage V sporulation protein T C-terminal, transcription factor PAS PF00989.25 EFC43579.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 1 0 0 1 1 1 0 PAS fold Zip PF02535.22 EFC43579.1 - 1.3 8.1 3.4 2.5 7.2 3.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Response_reg PF00072.24 EFC43580.1 - 1.6e-24 86.3 0.6 1.7e-24 86.1 0.6 1.0 1 0 0 1 1 1 1 Response regulator receiver domain CbiX PF01903.17 EFC43580.1 - 0.042 14.2 0.0 0.15 12.4 0.0 1.8 2 1 0 2 2 2 0 CbiX DUF934 PF06073.12 EFC43580.1 - 0.16 11.9 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF934) Form_Nir_trans PF01226.17 EFC43581.1 - 1e-63 214.9 18.0 1.2e-63 214.6 18.0 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter COX4 PF02936.14 EFC43581.1 - 0.0096 15.9 0.0 3.4 7.7 0.0 2.5 2 0 0 2 2 2 2 Cytochrome c oxidase subunit IV Na_H_antiport_1 PF06965.12 EFC43581.1 - 1.3 7.8 11.6 0.22 10.4 0.4 2.5 3 0 0 3 3 3 0 Na+/H+ antiporter 1 RhoGEF PF00621.20 EFC43582.1 - 2.1e-37 129.1 8.7 2.1e-37 129.1 8.7 2.9 3 0 0 3 3 3 1 RhoGEF domain SF3A3 PF16837.5 EFC43582.1 - 0.038 14.5 1.6 0.13 12.8 1.5 2.0 1 1 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 DinB PF05163.12 EFC43582.1 - 0.044 13.7 0.1 0.13 12.2 0.1 1.8 1 0 0 1 1 1 0 DinB family CHDCT2 PF08074.11 EFC43582.1 - 9.4 6.4 8.5 0.34 11.1 1.0 2.3 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain DUF4476 PF14771.6 EFC43583.1 - 0.016 15.5 1.0 0.053 13.8 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) Glyco_transf_36 PF06165.11 EFC43584.1 - 2.5e-145 482.5 0.3 2.5e-75 253.1 0.0 2.6 2 0 0 2 2 2 2 Glycosyltransferase family 36 Glyco_hydro_36 PF17167.4 EFC43584.1 - 2e-106 356.2 1.8 2.9e-106 355.7 1.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Glycoamylase PF10091.9 EFC43584.1 - 1.9e-06 27.6 0.0 4.3e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Putative glucoamylase ApoLp-III PF07464.11 EFC43584.1 - 2.5 8.2 4.3 5.7 7.0 1.0 2.7 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TPR_6 PF13174.6 EFC43585.1 - 0.012 16.2 0.0 0.04 14.6 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Guanylate_cyc PF00211.20 EFC43585.1 - 0.018 14.7 1.3 0.13 11.9 0.1 2.6 2 1 1 3 3 3 0 Adenylate and Guanylate cyclase catalytic domain DUF4919 PF16266.5 EFC43585.1 - 0.032 14.2 0.1 0.063 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4919) TPR_2 PF07719.17 EFC43585.1 - 0.046 13.9 0.1 0.31 11.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat PGAP1 PF07819.13 EFC43586.1 - 1.8e-12 47.5 0.6 3.7e-07 30.1 0.2 2.4 2 0 0 2 2 2 2 PGAP1-like protein Zip PF02535.22 EFC43587.1 - 1.6 7.9 17.2 2.6 7.2 17.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Spore_GerAC PF05504.11 EFC43588.1 - 0.0013 19.0 0.8 0.0024 18.1 0.8 1.4 1 0 0 1 1 1 1 Spore germination B3/ GerAC like, C-terminal ubiquitin PF00240.23 EFC43589.1 - 7.4e-63 208.2 5.9 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC43589.1 - 2.9e-30 103.9 7.5 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC43589.1 - 5.5e-09 36.4 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC43589.1 - 1.3e-08 34.6 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC43589.1 - 1.4e-08 34.8 0.4 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC43589.1 - 5.8e-07 29.8 1.6 0.025 14.9 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC43589.1 - 1.2e-06 29.0 0.1 0.015 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC43589.1 - 9e-05 22.4 6.5 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain Coagulin PF02035.15 EFC43589.1 - 0.043 13.7 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC43589.1 - 0.05 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC43589.1 - 0.072 13.5 1.0 0.84 10.0 0.2 2.5 2 1 0 3 3 3 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC43589.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC43589.1 - 0.14 12.3 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC43589.1 - 0.22 11.7 1.5 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain PAP2 PF01569.21 EFC43590.1 - 4.2e-17 62.2 2.7 6.8e-17 61.5 2.7 1.3 1 0 0 1 1 1 1 PAP2 superfamily Hydrolase_4 PF12146.8 EFC43591.1 - 6.6e-08 32.1 0.0 9.1e-08 31.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 EFC43591.1 - 5.9e-07 29.2 0.2 9.7e-07 28.5 0.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFC43591.1 - 2.9e-05 23.8 0.1 3.7e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 EFC43591.1 - 0.00015 22.5 0.0 0.00023 21.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC43591.1 - 0.0057 16.3 0.1 0.015 15.0 0.1 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold AXE1 PF05448.12 EFC43591.1 - 0.0062 15.3 0.7 0.39 9.4 0.2 2.4 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) Esterase PF00756.20 EFC43591.1 - 0.014 15.0 0.0 0.029 14.0 0.0 1.5 1 0 0 1 1 1 0 Putative esterase RAP PF08373.10 EFC43591.1 - 0.12 12.5 0.2 0.32 11.1 0.2 1.8 1 0 0 1 1 1 0 RAP domain G-alpha PF00503.20 EFC43592.1 - 4.7e-39 134.5 10.2 9.2e-39 133.6 10.2 1.4 1 0 0 1 1 1 1 G-protein alpha subunit F-box-like PF12937.7 EFC43592.1 - 0.00075 19.3 0.0 0.0021 17.9 0.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC43592.1 - 0.15 12.7 0.6 4.3 8.3 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC43592.1 - 0.16 11.7 5.0 6.3 6.6 0.1 3.5 3 0 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 EFC43592.1 - 0.81 10.2 11.1 2.5 8.6 0.1 4.6 3 1 1 5 5 5 0 Leucine Rich repeats (2 copies) REJ PF02010.15 EFC43593.1 - 2.3e-23 82.7 4.5 2.3e-23 82.7 4.5 1.6 2 0 0 2 2 2 1 REJ domain ASFV_J13L PF05568.11 EFC43593.1 - 0.0064 16.3 1.3 0.0064 16.3 1.3 2.5 3 0 0 3 3 3 1 African swine fever virus J13L protein SKG6 PF08693.10 EFC43593.1 - 1.1 8.7 7.8 2.5 7.6 7.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Insulin_TMD PF17870.1 EFC43593.1 - 2 8.6 10.5 0.41 10.8 3.6 2.9 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment eIF2_C PF09173.11 EFC43594.1 - 9.6e-36 121.9 0.5 2.3e-35 120.7 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 EFC43594.1 - 3.9e-22 78.7 1.1 3.4e-21 75.7 1.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFC43594.1 - 4e-11 43.2 1.8 4e-11 43.2 1.8 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 EFC43594.1 - 0.0035 17.3 0.9 0.037 14.0 0.2 2.5 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 EFC43594.1 - 0.0037 17.2 0.2 0.031 14.2 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC43594.1 - 0.0062 16.6 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 EFC43594.1 - 0.088 12.9 0.1 0.77 9.8 0.1 2.2 1 1 1 2 2 2 0 Dynamin family Peptidase_C1 PF00112.23 EFC43595.1 - 5.5e-43 147.6 2.9 1.1e-42 146.6 2.9 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC43595.1 - 0.00056 19.8 0.2 0.002 18.0 0.1 1.9 2 0 0 2 2 2 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EFC43595.1 - 0.0019 17.0 2.4 0.024 13.4 0.1 3.2 3 1 1 4 4 4 1 Peptidase C1-like family CathepsinC_exc PF08773.11 EFC43595.1 - 0.0085 16.4 2.1 0.0096 16.2 0.1 2.1 2 0 0 2 2 2 1 Cathepsin C exclusion domain F-box PF00646.33 EFC43596.1 - 0.0014 18.4 0.3 0.0036 17.1 0.3 1.8 1 1 0 1 1 1 1 F-box domain Leo1 PF04004.13 EFC43596.1 - 0.03 14.2 0.5 0.049 13.5 0.5 1.3 1 0 0 1 1 1 0 Leo1-like protein FlxA PF14282.6 EFC43596.1 - 0.052 13.5 1.0 0.052 13.5 1.0 2.0 2 1 0 2 2 2 0 FlxA-like protein Allexi_40kDa PF05549.11 EFC43596.1 - 0.1 12.1 1.8 0.13 11.8 1.8 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Snapin_Pallidin PF14712.6 EFC43596.1 - 0.26 11.7 6.2 0.35 11.3 4.2 2.0 1 1 1 2 2 2 0 Snapin/Pallidin Baculo_p24 PF05073.12 EFC43596.1 - 0.52 10.1 6.9 0.83 9.4 6.9 1.3 1 1 0 1 1 1 0 Baculovirus P24 capsid protein Peptidase_C1 PF00112.23 EFC43597.1 - 1.2e-45 156.3 2.7 1.3e-45 156.2 2.7 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Ras PF00071.22 EFC43598.1 - 3.9e-21 75.3 0.0 6.1e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43598.1 - 5.2e-07 29.9 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RNF220 PF15926.5 EFC43599.1 - 0.09 12.4 0.1 0.14 11.7 0.1 1.4 1 1 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 zf-C2HC_2 PF13913.6 EFC43599.1 - 0.2 11.6 0.3 0.3 11.0 0.3 1.3 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Glyco_transf_18 PF15024.6 EFC43600.1 - 2e-09 36.6 12.2 3.5e-09 35.8 12.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 18 Mucin PF01456.17 EFC43603.1 - 0.0042 17.1 5.3 0.0069 16.4 5.3 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein Shisa PF13908.6 EFC43603.1 - 0.02 15.2 4.1 0.02 15.2 4.1 1.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator ELH PF02323.15 EFC43603.1 - 0.047 13.1 1.5 0.062 12.7 1.5 1.2 1 0 0 1 1 1 0 Egg-laying hormone precursor EphA2_TM PF14575.6 EFC43603.1 - 0.17 12.8 0.8 0.42 11.5 0.8 1.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SprT-like PF10263.9 EFC43604.1 - 1.1e-22 80.0 0.8 2.2e-22 79.0 0.1 1.9 2 0 0 2 2 2 1 SprT-like family Aa_trans PF01490.18 EFC43605.1 - 1.3e-11 43.9 11.5 6.2e-07 28.5 5.5 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Cortexin PF11057.8 EFC43605.1 - 0.015 15.1 0.5 0.051 13.4 0.5 1.9 1 0 0 1 1 1 0 Cortexin of kidney DUF3382 PF11862.8 EFC43605.1 - 0.027 14.7 0.9 1.1 9.5 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) Tfb2 PF03849.14 EFC43606.1 - 8.6e-103 344.0 10.7 1.4e-102 343.3 10.7 1.3 1 1 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 EFC43606.1 - 3.8e-23 81.7 0.4 8.4e-23 80.6 0.4 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain SinI PF08671.10 EFC43606.1 - 0.01 15.6 0.0 0.028 14.2 0.0 1.8 1 0 0 1 1 1 0 Anti-repressor SinI KH_1 PF00013.29 EFC43607.1 - 0.0026 17.5 3.0 0.0033 17.2 0.3 2.3 2 0 0 2 2 2 1 KH domain LRRC37AB_C PF14914.6 EFC43607.1 - 0.16 11.9 0.3 0.16 11.9 0.3 2.6 2 1 1 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain L27_N PF09060.10 EFC43607.1 - 0.19 11.8 1.0 0.41 10.8 0.1 1.9 2 0 0 2 2 2 0 L27_N rhaM PF05336.13 EFC43608.1 - 0.0059 16.7 1.7 0.69 10.0 0.3 2.6 2 0 0 2 2 2 2 L-rhamnose mutarotase HNH PF01844.23 EFC43608.1 - 0.33 11.2 6.0 1 9.6 6.0 1.9 1 0 0 1 1 1 0 HNH endonuclease ADD_DNMT3 PF17980.1 EFC43608.1 - 0.44 10.6 4.2 1.3 9.0 0.1 2.9 3 0 0 3 3 3 0 Cysteine rich ADD domain in DNMT3 Glyco_hydro_1 PF00232.18 EFC43609.1 - 1.2e-165 551.4 2.9 1.3e-165 551.2 2.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 NUDIX PF00293.28 EFC43611.1 - 2.1e-12 47.2 0.0 3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Glyco_hydro_97 PF10566.9 EFC43611.1 - 0.022 14.0 0.2 0.037 13.3 0.2 1.3 1 0 0 1 1 1 0 Glycoside hydrolase 97 NUDIX_2 PF13869.6 EFC43611.1 - 0.067 12.8 0.5 0.1 12.2 0.1 1.5 2 0 0 2 2 2 0 Nucleotide hydrolase Pkinase PF00069.25 EFC43613.1 - 1.3e-44 152.5 2.6 1.3e-44 152.5 2.6 3.7 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43613.1 - 1.6e-28 99.7 1.7 1.6e-28 99.7 1.7 3.7 4 1 0 4 4 4 1 Protein tyrosine kinase HEAT_2 PF13646.6 EFC43613.1 - 6e-19 68.2 2.5 2.9e-09 37.2 0.3 6.1 3 2 4 7 7 7 5 HEAT repeats HEAT PF02985.22 EFC43613.1 - 6.7e-07 29.0 0.8 0.16 12.3 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat NACHT PF05729.12 EFC43613.1 - 7.1e-05 22.8 0.0 0.0004 20.3 0.0 2.4 1 0 0 1 1 1 1 NACHT domain PC_rep PF01851.22 EFC43613.1 - 0.0039 17.6 1.7 0.33 11.5 0.1 4.4 5 0 0 5 5 5 1 Proteasome/cyclosome repeat APH PF01636.23 EFC43613.1 - 0.0047 16.9 0.0 1.9 8.3 0.0 2.4 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC43613.1 - 0.0073 15.7 0.7 0.96 8.7 0.0 3.2 3 0 0 3 3 3 1 Kinase-like HEAT_EZ PF13513.6 EFC43613.1 - 0.011 16.2 0.0 8.7 7.0 0.0 3.9 3 0 0 3 3 3 0 HEAT-like repeat Roc PF08477.13 EFC43613.1 - 0.044 14.0 0.5 0.32 11.2 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 EFC43614.1 - 4.6e-12 45.9 7.4 3.5e-09 36.4 0.4 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43614.1 - 2.6e-07 30.2 0.1 6.1e-07 29.0 0.1 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase IBR PF01485.21 EFC43615.1 - 2.6e-10 40.3 40.9 1.4e-06 28.4 12.1 4.9 4 1 1 5 5 5 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFC43615.1 - 0.00012 22.4 7.9 0.00012 22.4 7.9 4.3 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC43615.1 - 0.0061 16.4 5.5 0.0061 16.4 5.5 5.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) RHSP PF07999.11 EFC43615.1 - 0.056 12.2 0.5 0.11 11.3 0.5 1.5 1 0 0 1 1 1 0 Retrotransposon hot spot protein EF-G-binding_N PF07299.11 EFC43615.1 - 0.074 13.6 1.6 0.26 11.8 0.1 2.7 3 0 0 3 3 3 0 Elongation factor G-binding protein, N-terminal DUF3452 PF11934.8 EFC43616.1 - 0.0049 16.4 0.7 0.01 15.4 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3452) SPAM PF02090.15 EFC43616.1 - 0.56 10.0 8.7 1.8 8.4 8.7 1.8 1 1 0 1 1 1 0 Salmonella surface presentation of antigen gene type M protein PAN_3 PF08277.12 EFC43617.1 - 0.7 9.7 8.4 2.3 8.1 1.6 3.3 2 1 1 3 3 3 0 PAN-like domain YL1 PF05764.13 EFC43617.1 - 2.4 8.2 12.5 0.77 9.8 9.2 1.6 1 1 0 1 1 1 0 YL1 nuclear protein Vps35 PF03635.17 EFC43618.1 - 4.1e-10 38.8 9.6 4.1e-10 38.8 9.6 2.4 2 0 0 2 2 2 1 Vacuolar protein sorting-associated protein 35 NTS PF15447.6 EFC43618.1 - 0.05 14.1 0.0 0.21 12.1 0.0 2.0 1 0 0 1 1 1 0 N-terminal segments of PfEMP1 Phage_TAC_8 PF10666.9 EFC43618.1 - 0.087 13.1 1.3 0.79 10.0 0.2 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Gp14 ()A118 DUF934 PF06073.12 EFC43618.1 - 0.15 11.9 0.0 4.9 7.1 0.0 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF934) Ependymin PF00811.18 EFC43619.1 - 1.2e-13 51.5 0.0 1.6e-13 51.0 0.0 1.2 1 0 0 1 1 1 1 Ependymin PsaD PF02531.16 EFC43619.1 - 0.2 11.2 0.0 0.71 9.4 0.0 1.9 2 0 0 2 2 2 0 PsaD Pro_isomerase PF00160.21 EFC43620.1 - 3.2e-20 73.0 0.0 3.9e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD F-box-like PF12937.7 EFC43621.1 - 0.0023 17.8 0.0 0.0059 16.5 0.0 1.7 1 0 0 1 1 1 1 F-box-like MADF_DNA_bdg PF10545.9 EFC43621.1 - 0.041 14.2 0.1 0.1 12.9 0.1 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like HlyIII PF03006.20 EFC43622.1 - 7.9e-24 84.6 16.5 1.1e-23 84.1 16.5 1.2 1 0 0 1 1 1 1 Haemolysin-III related DUF5464 PF17552.2 EFC43623.1 - 0.14 12.4 6.6 0.36 11.1 6.6 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5464) Doppel PF11466.8 EFC43623.1 - 7.1 6.4 9.7 15 5.3 9.7 1.5 1 0 0 1 1 1 0 Prion-like protein Doppel F-box-like PF12937.7 EFC43624.1 - 4.9e-05 23.1 0.0 0.00012 21.9 0.0 1.6 1 0 0 1 1 1 1 F-box-like Ank_4 PF13637.6 EFC43624.1 - 0.00047 20.7 0.2 0.0021 18.6 0.2 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC43624.1 - 0.0012 19.4 0.0 0.0029 18.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC43624.1 - 0.0082 16.6 1.1 0.047 14.3 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 EFC43624.1 - 0.015 15.7 0.1 0.075 13.5 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EFC43624.1 - 0.033 14.5 0.1 0.3 11.4 0.1 2.6 3 0 0 3 3 3 0 Ankyrin repeats (many copies) PseudoU_synth_1 PF01416.20 EFC43626.1 - 7.4e-21 74.6 0.0 2.6e-15 56.8 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase LisH_2 PF16045.5 EFC43627.1 - 4e-09 35.3 0.0 9.2e-09 34.2 0.0 1.7 1 0 0 1 1 1 1 LisH FOP_dimer PF09398.10 EFC43627.1 - 0.00013 22.2 0.0 0.00031 20.9 0.0 1.6 1 0 0 1 1 1 1 FOP N terminal dimerisation domain Ribosomal_60s PF00428.19 EFC43628.1 - 6.4e-20 71.5 8.7 7.4e-20 71.3 8.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein NolX PF05819.11 EFC43628.1 - 0.0054 16.1 0.7 0.0061 15.9 0.7 1.0 1 0 0 1 1 1 1 NolX protein DUF2057 PF09829.9 EFC43628.1 - 0.13 12.4 0.2 0.15 12.2 0.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) RhoGEF PF00621.20 EFC43629.1 - 9.8e-54 182.3 5.0 3e-53 180.8 5.0 1.9 1 0 0 1 1 1 1 RhoGEF domain RCC1 PF00415.18 EFC43629.1 - 1.2e-35 121.9 19.2 3.9e-11 43.4 0.6 7.2 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat FYVE PF01363.21 EFC43629.1 - 1.8e-21 76.1 6.9 3.6e-21 75.1 6.9 1.5 1 0 0 1 1 1 1 FYVE zinc finger RCC1_2 PF13540.6 EFC43629.1 - 5.2e-12 45.2 16.9 1.1e-06 28.3 0.5 4.9 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat PH_12 PF16457.5 EFC43629.1 - 4.1e-07 30.6 0.0 4.1e-07 30.6 0.0 2.9 4 0 0 4 4 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 EFC43629.1 - 4.3e-07 30.1 0.1 8.8e-06 25.8 0.0 2.9 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 EFC43629.1 - 1.9e-06 28.3 0.3 0.0017 18.8 0.0 2.9 2 0 0 2 2 2 2 PH domain PH_2 PF08458.10 EFC43629.1 - 0.0005 20.4 0.1 0.043 14.2 0.0 2.6 2 0 0 2 2 2 1 Plant pleckstrin homology-like region PH_16 PF17838.1 EFC43629.1 - 0.00099 18.9 1.4 0.0068 16.2 0.6 2.6 2 1 0 2 2 2 1 PH domain IQ PF00612.27 EFC43629.1 - 0.0048 16.6 3.2 0.013 15.3 0.7 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif Glyco_hydro_65C PF03633.15 EFC43629.1 - 0.087 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain FYVE_2 PF02318.16 EFC43629.1 - 0.49 10.6 7.8 0.25 11.6 4.5 2.1 2 0 0 2 2 2 0 FYVE-type zinc finger PH_13 PF16652.5 EFC43629.1 - 0.61 9.9 8.7 0.15 11.9 0.7 3.3 3 2 1 4 4 4 0 Pleckstrin homology domain SF3A3 PF16837.5 EFC43629.1 - 0.77 10.3 3.0 1.9 9.1 0.7 2.6 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-AN1 PF01428.16 EFC43629.1 - 8.1 6.7 9.9 22 5.3 9.9 1.7 1 0 0 1 1 1 0 AN1-like Zinc finger NEMP PF10225.9 EFC43630.1 - 1.4 8.6 9.4 11 5.5 0.2 2.3 1 1 1 2 2 2 0 NEMP family ubiquitin PF00240.23 EFC43631.1 - 7.4e-63 208.2 5.9 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC43631.1 - 2.9e-30 103.9 7.5 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC43631.1 - 5.5e-09 36.4 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC43631.1 - 1.3e-08 34.6 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC43631.1 - 1.4e-08 34.8 0.4 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC43631.1 - 5.8e-07 29.8 1.6 0.025 14.9 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC43631.1 - 1.2e-06 29.0 0.1 0.015 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC43631.1 - 9e-05 22.4 6.5 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain Coagulin PF02035.15 EFC43631.1 - 0.043 13.7 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC43631.1 - 0.05 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC43631.1 - 0.072 13.5 1.0 0.84 10.0 0.2 2.5 2 1 0 3 3 3 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC43631.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC43631.1 - 0.14 12.3 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC43631.1 - 0.22 11.7 1.5 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain GTP_EFTU PF00009.27 EFC43632.1 - 3.1e-20 72.5 0.0 4e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC43632.1 - 4.6e-10 39.8 0.1 1.3e-09 38.4 0.0 1.7 2 0 0 2 2 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC43632.1 - 6.7e-09 36.0 1.3 1.3e-08 35.1 0.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC43632.1 - 6.2e-05 23.0 0.0 0.00016 21.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 EFC43632.1 - 0.00013 21.8 2.0 0.00026 20.8 2.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Gtr1_RagA PF04670.12 EFC43632.1 - 0.0012 18.2 1.3 0.0031 16.9 1.3 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Rad17 PF03215.15 EFC43632.1 - 0.0092 15.9 0.4 0.028 14.3 0.4 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain PduV-EutP PF10662.9 EFC43632.1 - 0.0096 15.7 0.5 1.8 8.3 0.0 2.9 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 EFC43632.1 - 0.011 15.5 0.2 0.03 14.1 0.2 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC43632.1 - 0.012 15.5 0.3 0.082 12.8 0.3 2.2 1 1 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 EFC43632.1 - 0.031 14.8 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Dynamin_N PF00350.23 EFC43632.1 - 0.044 13.8 1.0 8.9 6.3 0.3 2.5 1 1 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 EFC43632.1 - 0.062 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EFC43632.1 - 0.14 12.1 0.1 0.33 10.8 0.1 1.6 1 0 0 1 1 1 0 NACHT domain G-alpha PF00503.20 EFC43632.1 - 0.14 11.3 1.1 0.39 9.8 0.9 1.8 1 1 1 2 2 2 0 G-protein alpha subunit AAA_5 PF07728.14 EFC43632.1 - 0.18 11.8 0.0 0.42 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF3198 PF11433.8 EFC43632.1 - 0.19 11.7 0.2 66 3.5 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3198) Roc PF08477.13 EFC43632.1 - 0.29 11.4 1.1 3 8.1 0.5 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Alpha-amylase PF00128.24 EFC43633.1 - 6.7e-58 196.9 0.3 4e-57 194.3 0.3 2.0 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 EFC43633.1 - 0.012 15.9 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1966) hDGE_amylase PF14701.6 EFC43633.1 - 0.014 14.5 0.1 0.024 13.8 0.1 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DSPc PF00782.20 EFC43634.1 - 5.1e-06 26.3 0.1 7.9e-06 25.7 0.1 1.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFC43634.1 - 2.3e-05 24.5 0.0 2.8e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC43634.1 - 3.3e-05 23.6 0.0 3.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFC43634.1 - 0.00066 19.8 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EFC43634.1 - 0.011 15.4 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family MACPF PF01823.19 EFC43635.1 - 1.6e-08 34.9 0.9 0.00033 20.8 0.2 2.3 2 0 0 2 2 2 2 MAC/Perforin domain DUF3725 PF12523.8 EFC43635.1 - 0.11 12.8 0.3 0.29 11.5 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) FGGY_C PF02782.16 EFC43636.1 - 5.9e-35 120.8 0.0 3.6e-34 118.2 0.0 2.2 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 EFC43636.1 - 1.2e-08 34.8 3.2 9.4e-06 25.4 3.2 3.4 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain MatE PF01554.18 EFC43637.1 - 2.3e-50 170.4 39.9 3.1e-31 108.2 14.2 2.5 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 EFC43637.1 - 4e-06 27.0 2.8 4e-06 27.0 2.8 4.2 4 2 0 4 4 4 1 Polysaccharide biosynthesis C-terminal domain UPF0242 PF06785.11 EFC43637.1 - 1.9 8.6 5.8 4.9 7.2 5.8 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2418 PF10332.9 EFC43637.1 - 9.7 6.8 6.4 1.8 9.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2418) HAUS2 PF15003.6 EFC43638.1 - 4.4e-13 49.4 6.4 5.6e-13 49.1 6.4 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 2 UvsY PF11056.8 EFC43638.1 - 0.015 15.6 4.4 0.95 9.8 0.1 2.4 1 1 1 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY DUF948 PF06103.11 EFC43638.1 - 0.064 13.5 1.2 0.7 10.2 0.1 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Ribosomal_S19e PF01090.19 EFC43639.1 - 1.2e-52 177.3 0.2 1.3e-52 177.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e DUF1529 PF07485.11 EFC43639.1 - 0.01 15.7 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1259) YEATS PF03366.16 EFC43641.1 - 1e-12 47.8 0.1 3.6e-12 46.1 0.1 1.9 2 0 0 2 2 2 1 YEATS family SBP PF03110.14 EFC43641.1 - 0.019 15.2 1.1 0.019 15.2 1.1 2.1 2 0 0 2 2 2 0 SBP domain SapB_1 PF05184.15 EFC43642.1 - 0.016 15.2 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 0 Saposin-like type B, region 1 NTP_transf_2 PF01909.23 EFC43642.1 - 0.033 14.5 0.7 0.23 11.8 0.2 2.7 2 0 0 2 2 2 0 Nucleotidyltransferase domain Polbeta PF18765.1 EFC43642.1 - 0.039 14.0 1.3 0.2 11.7 0.2 2.8 2 1 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase Orthopox_B11R PF07033.11 EFC43642.1 - 0.17 11.7 2.2 0.19 11.5 0.4 2.0 2 0 0 2 2 2 0 Orthopoxvirus B11R protein LRR_9 PF14580.6 EFC43643.1 - 1.1e-17 64.1 2.1 2e-17 63.2 2.1 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC43643.1 - 1.1e-11 44.8 21.3 8.1e-07 29.3 2.7 4.0 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43643.1 - 0.0001 22.0 10.4 0.0023 17.6 3.3 3.1 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EFC43643.1 - 0.33 11.7 7.0 21 6.2 0.1 4.5 4 2 0 4 4 4 0 Leucine Rich Repeat RabGAP-TBC PF00566.18 EFC43644.1 - 0.14 11.8 1.5 0.21 11.2 1.5 1.2 1 0 0 1 1 1 0 Rab-GTPase-TBC domain UDPG_MGDP_dh_N PF03721.14 EFC43645.1 - 0.0089 15.6 0.7 0.019 14.6 0.7 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PrlF_antitoxin PF15937.5 EFC43645.1 - 0.076 13.5 0.1 0.21 12.0 0.1 1.7 1 0 0 1 1 1 0 prlF antitoxin for toxin YhaV_toxin Filamin PF00630.19 EFC43646.1 - 1.5e-83 276.3 16.7 8.6e-17 61.8 0.1 8.6 8 1 0 8 8 8 7 Filamin/ABP280 repeat CH PF00307.31 EFC43646.1 - 7.2e-32 109.8 0.1 1.9e-16 60.2 0.0 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain Invasin_D3 PF09134.10 EFC43646.1 - 1.5e-15 57.3 0.9 0.0051 17.1 0.1 5.7 5 1 0 5 5 5 3 Invasin, domain 3 YtkA PF13115.6 EFC43646.1 - 5.8e-06 26.8 0.5 0.24 12.0 0.0 5.6 6 0 0 6 6 6 1 YtkA-like CAMSAP_CH PF11971.8 EFC43646.1 - 3.3e-05 23.6 0.0 0.00029 20.6 0.0 2.4 2 0 0 2 2 2 1 CAMSAP CH domain Big_6 PF17936.1 EFC43646.1 - 0.0048 17.1 0.3 8.1 6.8 0.0 4.7 5 0 0 5 5 5 1 Bacterial Ig domain DUF5060 PF16586.5 EFC43646.1 - 0.0071 16.7 0.0 34 4.9 0.0 4.9 6 0 0 6 6 6 0 Domain of unknown function (DUF5060) Neurexophilin PF06312.12 EFC43646.1 - 0.0091 15.5 0.1 0.58 9.6 0.0 3.3 3 0 0 3 3 3 1 Neurexophilin Big_1 PF02369.16 EFC43646.1 - 0.0099 15.9 8.0 3 7.9 0.2 5.9 6 1 1 7 7 7 1 Bacterial Ig-like domain (group 1) Cadherin_5 PF17892.1 EFC43646.1 - 0.02 14.8 1.5 5.5 7.0 0.1 3.8 3 0 0 3 3 3 0 Cadherin-like domain GPI-anchored PF10342.9 EFC43646.1 - 0.039 14.7 1.4 8.9 7.1 0.0 4.3 4 0 0 4 4 3 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Big_3 PF07523.12 EFC43646.1 - 0.054 13.8 0.6 0.9 9.9 0.1 3.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) DUF3164 PF11363.8 EFC43646.1 - 0.074 12.7 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) Big_3_5 PF16640.5 EFC43646.1 - 0.11 12.7 0.1 29 4.9 0.0 3.7 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) Big_7 PF17957.1 EFC43646.1 - 0.47 11.2 3.0 45 4.9 0.0 4.1 4 0 0 4 4 3 0 Bacterial Ig domain Y_Y_Y PF07495.13 EFC43646.1 - 3.2 7.8 5.0 32 4.6 0.4 4.2 4 1 1 5 5 5 0 Y_Y_Y domain adh_short PF00106.25 EFC43647.1 - 6.8e-29 100.7 1.1 7.3e-28 97.4 1.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43647.1 - 4.5e-20 72.2 0.1 3.7e-19 69.2 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43647.1 - 0.0032 17.4 0.1 0.0049 16.8 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFC43647.1 - 0.05 13.0 0.1 0.069 12.5 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 EFC43647.1 - 0.098 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain PPP4R2 PF09184.11 EFC43648.1 - 3e-05 23.7 19.9 3.7e-05 23.4 19.9 1.2 1 0 0 1 1 1 1 PPP4R2 CDC27 PF09507.10 EFC43648.1 - 0.00011 21.7 15.0 0.00012 21.6 15.0 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 RNA_pol_3_Rpc31 PF11705.8 EFC43648.1 - 0.001 19.4 18.9 0.0012 19.2 18.9 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Prothymosin PF03247.14 EFC43648.1 - 0.0048 17.3 36.2 0.0074 16.7 36.2 1.3 1 0 0 1 1 1 1 Prothymosin/parathymosin family Nop14 PF04147.12 EFC43648.1 - 0.022 13.0 23.2 0.023 13.0 23.2 1.1 1 0 0 1 1 1 0 Nop14-like family WAP PF00095.21 EFC43648.1 - 0.024 15.0 0.2 0.047 14.1 0.2 1.4 1 0 0 1 1 1 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' Mpp10 PF04006.12 EFC43648.1 - 0.029 12.8 25.1 0.035 12.6 25.1 1.0 1 0 0 1 1 1 0 Mpp10 protein Nodulin_late PF07127.11 EFC43648.1 - 0.05 13.9 0.2 0.092 13.1 0.2 1.4 1 0 0 1 1 1 0 Late nodulin protein CDC45 PF02724.14 EFC43648.1 - 0.097 11.0 16.1 0.11 10.8 16.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DcuA_DcuB PF03605.14 EFC43648.1 - 0.099 11.5 1.4 0.35 9.7 0.4 1.9 2 0 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter HTH_36 PF13730.6 EFC43648.1 - 0.14 12.1 0.6 14 5.8 0.1 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain DUF5523 PF17661.1 EFC43648.1 - 0.22 11.2 18.2 0.25 11.0 18.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DDHD PF02862.17 EFC43648.1 - 0.38 10.9 7.1 0.48 10.6 7.1 1.3 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 EFC43648.1 - 0.42 10.4 15.7 0.46 10.3 15.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIA PF03153.13 EFC43648.1 - 0.43 10.5 22.5 0.45 10.4 22.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CobT PF06213.12 EFC43648.1 - 0.58 9.5 23.3 0.65 9.3 23.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nucleo_P87 PF07267.11 EFC43648.1 - 0.81 8.5 10.4 0.85 8.4 10.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Cwf_Cwc_15 PF04889.12 EFC43648.1 - 0.97 9.1 21.7 1.3 8.7 21.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein V_ATPase_I PF01496.19 EFC43648.1 - 1.2 7.0 8.7 1.1 7.1 8.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Paf1 PF03985.13 EFC43648.1 - 3.1 6.7 24.7 3.8 6.4 24.7 1.1 1 0 0 1 1 1 0 Paf1 DUF4746 PF15928.5 EFC43648.1 - 7.5 5.9 19.4 9.6 5.5 19.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF3602 PF12223.8 EFC43648.1 - 7.8 7.2 9.3 14 6.4 9.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3602) CLN3 PF02487.17 EFC43648.1 - 9.1 5.2 6.2 11 4.9 6.0 1.3 1 1 0 1 1 1 0 CLN3 protein FSA_C PF10479.9 EFC43648.1 - 9.4 4.2 12.1 11 4.0 12.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PIG-H PF10181.9 EFC43649.1 - 5.9e-17 61.3 0.3 1.2e-16 60.3 0.3 1.5 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component NUC173 PF08161.12 EFC43651.1 - 1.7e-17 63.7 1.5 9.9e-16 58.0 0.0 4.3 5 0 0 5 5 5 1 NUC173 domain DUF4042 PF13251.6 EFC43651.1 - 0.0032 17.2 0.2 0.0032 17.2 0.2 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4042) RTP1_C1 PF10363.9 EFC43651.1 - 0.023 14.9 0.2 74 3.6 0.0 4.5 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF4004 PF13171.6 EFC43651.1 - 0.72 10.1 10.1 0.86 9.8 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4004) NUDIX PF00293.28 EFC43652.1 - 1e-14 54.7 0.1 1.4e-14 54.3 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain Nudix_N_2 PF14803.6 EFC43652.1 - 0.0087 16.0 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Nudix N-terminal ADK_lid PF05191.14 EFC43652.1 - 0.12 12.4 0.3 0.62 10.1 0.1 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid tRNA-synt_2 PF00152.20 EFC43653.1 - 3.7e-89 298.9 0.3 4.8e-89 298.5 0.3 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFC43653.1 - 4.1e-08 33.1 0.0 8.5e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFC43653.1 - 0.0087 15.6 0.1 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) WD40 PF00400.32 EFC43654.1 - 0.0017 19.1 1.7 0.41 11.6 0.1 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC43654.1 - 0.0023 18.2 0.0 1.4 9.2 0.0 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4125 PF13526.6 EFC43655.1 - 3.2e-05 23.6 1.1 4.4e-05 23.2 1.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4125) CLTH PF10607.9 EFC43655.1 - 0.43 10.5 7.3 0.14 12.1 2.8 2.1 1 1 1 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Coq4 PF05019.13 EFC43656.1 - 2.3e-79 265.8 0.0 2.6e-79 265.6 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 TPR_1 PF00515.28 EFC43657.1 - 6.1e-10 38.5 13.5 0.0093 15.8 0.2 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC43657.1 - 3.4e-09 36.1 9.6 0.074 13.2 0.1 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC43657.1 - 1.6e-06 28.3 1.6 0.026 14.8 0.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43657.1 - 3e-05 23.9 8.8 0.044 14.0 0.3 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC43657.1 - 5.8e-05 23.6 0.3 0.81 10.7 0.0 4.5 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC43657.1 - 0.00019 22.0 0.1 0.29 11.8 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC43657.1 - 0.00026 20.8 1.1 0.16 12.1 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC43657.1 - 0.00033 20.3 5.3 0.017 14.8 0.0 3.5 3 0 0 3 3 3 1 TPR repeat TPR_19 PF14559.6 EFC43657.1 - 0.00055 20.4 6.5 0.0081 16.6 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC43657.1 - 0.00098 18.9 0.4 0.011 15.5 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC43657.1 - 0.0014 18.8 14.8 0.0049 17.1 6.7 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC43657.1 - 0.0067 16.7 5.2 1 9.9 0.9 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat IstB_IS21 PF01695.17 EFC43657.1 - 0.059 13.1 0.1 0.22 11.2 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein TPR_20 PF14561.6 EFC43657.1 - 0.066 13.6 3.5 11 6.5 0.0 4.5 4 2 1 5 5 5 0 Tetratricopeptide repeat CDK2AP PF09806.9 EFC43657.1 - 0.22 11.6 6.5 0.066 13.3 3.2 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein TPR_6 PF13174.6 EFC43657.1 - 1.8 9.4 6.7 1.7e+02 3.2 0.0 5.4 6 1 0 6 6 5 0 Tetratricopeptide repeat DUF1635 PF07795.11 EFC43657.1 - 1.8 8.3 10.9 0.18 11.6 6.4 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF1635) SKA1 PF07160.12 EFC43657.1 - 3.1 7.6 15.8 4.5 7.1 10.9 2.4 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Neur_chan_memb PF02932.16 EFC43657.1 - 3.8 7.5 5.9 2.1 8.3 3.3 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GTP_EFTU_D2 PF03144.25 EFC43658.1 - 1.8e-08 34.7 0.9 5.1e-08 33.2 1.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EFC43658.1 - 0.0031 17.8 0.1 0.011 16.1 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain Arrestin_C PF02752.22 EFC43659.1 - 5.4e-20 72.2 0.0 5.8e-17 62.4 0.1 2.3 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFC43659.1 - 1.8e-17 63.8 0.6 3.9e-11 43.2 0.0 3.2 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EFC43659.1 - 4.8e-06 26.3 0.0 0.0042 16.7 0.0 2.6 3 0 0 3 3 3 2 SpoOM protein Rgp1 PF08737.10 EFC43659.1 - 0.059 12.5 0.6 12 4.9 0.0 3.3 3 1 1 4 4 4 0 Rgp1 MG2 PF01835.19 EFC43659.1 - 0.076 13.5 0.1 0.82 10.2 0.0 2.4 2 1 0 2 2 2 0 MG2 domain Actin PF00022.19 EFC43660.1 - 1.9e-80 270.5 0.0 6.5e-79 265.4 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC43660.1 - 0.0045 15.9 0.0 0.017 14.0 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein Cullin_binding PF03556.15 EFC43661.1 - 2.7e-28 98.8 4.0 4.8e-28 98.0 4.0 1.4 1 0 0 1 1 1 1 Cullin binding Macoilin PF09726.9 EFC43661.1 - 0.26 9.8 8.9 0.29 9.6 8.9 1.2 1 0 0 1 1 1 0 Macoilin family Membralin PF09746.9 EFC43661.1 - 0.85 8.6 6.6 0.57 9.2 5.1 1.4 1 1 0 1 1 1 0 Tumour-associated protein SOG2 PF10428.9 EFC43661.1 - 0.92 8.6 13.4 1.5 8.0 13.4 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Neur_chan_memb PF02932.16 EFC43661.1 - 3.9 7.5 7.5 21 5.1 5.3 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Adaptin_N PF01602.20 EFC43662.1 - 1.5e-108 363.6 13.1 1.8e-108 363.4 13.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFC43662.1 - 9.3e-19 68.0 2.4 4.1e-12 46.4 0.0 2.6 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFC43662.1 - 9.3e-06 25.5 0.0 4.4 7.8 0.0 5.1 4 0 0 4 4 4 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EFC43662.1 - 0.00056 20.4 2.3 0.062 13.9 0.1 3.9 2 1 2 4 4 4 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFC43662.1 - 0.00098 19.6 0.0 7.4 7.2 0.0 4.3 4 0 0 4 4 4 1 HEAT-like repeat Cohesin_HEAT PF12765.7 EFC43662.1 - 0.0048 17.2 0.1 0.52 10.7 0.0 2.8 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion RTP1_C1 PF10363.9 EFC43662.1 - 0.016 15.4 0.4 5 7.4 0.0 3.6 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 V-ATPase_H_C PF11698.8 EFC43662.1 - 0.024 14.8 2.4 0.22 11.7 0.1 3.6 3 1 0 3 3 3 0 V-ATPase subunit H PPTA PF01239.22 EFC43663.1 - 4.3e-44 147.0 16.7 1.8e-10 40.2 0.1 5.2 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat TPR_14 PF13428.6 EFC43663.1 - 0.0043 17.8 0.1 2.7 9.0 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat PSCyt2 PF07583.11 EFC43663.1 - 0.3 11.0 6.0 8.5 6.2 2.8 3.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1549) TPR_17 PF13431.6 EFC43663.1 - 4.1 8.0 6.6 2.9 8.5 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat YL1 PF05764.13 EFC43664.1 - 0.046 13.8 10.9 0.061 13.4 10.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Kelch_4 PF13418.6 EFC43665.1 - 5.3e-18 64.8 4.8 5.1e-09 36.0 0.0 4.0 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC43665.1 - 7.3e-14 51.4 8.3 1.1e-08 34.8 0.0 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 EFC43665.1 - 3.3e-13 49.4 1.6 6.6e-06 26.2 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EFC43665.1 - 2.9e-12 45.9 0.9 1.8e-08 33.8 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 EFC43665.1 - 2e-11 43.9 1.7 8.2e-05 22.8 0.1 4.2 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC43665.1 - 3.5e-10 39.4 0.8 2.6e-06 27.2 0.0 3.9 4 0 0 4 4 4 1 Kelch motif BTB PF00651.31 EFC43665.1 - 1.6e-09 38.0 3.5 4.4e-09 36.5 0.1 2.9 3 1 1 4 4 4 1 BTB/POZ domain RAG2 PF03089.14 EFC43665.1 - 0.00081 18.5 0.0 0.0022 17.1 0.0 1.7 1 1 0 1 1 1 1 Recombination activating protein 2 BACK PF07707.15 EFC43665.1 - 0.043 13.9 3.2 0.054 13.6 0.0 2.7 4 0 0 4 4 4 0 BTB And C-terminal Kelch DUF2430 PF10353.9 EFC43665.1 - 0.045 14.2 0.2 0.18 12.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2430) AAA PF00004.29 EFC43666.1 - 5.1e-52 175.8 0.2 7.2e-37 126.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC43666.1 - 5.2e-11 42.2 0.1 1.8e-10 40.4 0.0 2.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_22 PF13401.6 EFC43666.1 - 3.4e-10 40.3 0.8 0.00015 22.0 0.0 3.7 2 1 1 3 3 3 2 AAA domain AAA_18 PF13238.6 EFC43666.1 - 3.6e-10 40.5 0.2 0.0014 19.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_24 PF13479.6 EFC43666.1 - 8.7e-08 32.1 0.1 0.0051 16.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFC43666.1 - 1.7e-07 31.8 0.0 0.019 15.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 EFC43666.1 - 6.7e-07 29.4 0.2 0.0056 16.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 EFC43666.1 - 8.2e-07 29.4 1.5 0.0073 16.6 0.3 2.7 3 0 0 3 3 2 2 AAA domain AAA_2 PF07724.14 EFC43666.1 - 3.2e-06 27.4 0.1 0.0014 18.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 EFC43666.1 - 5e-06 26.7 0.0 0.11 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EFC43666.1 - 5.8e-06 26.6 0.0 0.19 12.1 0.0 2.7 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 EFC43666.1 - 7.1e-06 25.5 0.3 0.0044 16.4 0.0 2.6 3 0 0 3 3 2 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 EFC43666.1 - 7.7e-06 25.9 0.1 0.097 12.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 EFC43666.1 - 1.2e-05 25.1 0.1 0.016 14.9 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain RuvB_N PF05496.12 EFC43666.1 - 1.5e-05 24.8 0.6 0.28 10.9 0.1 3.1 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 EFC43666.1 - 1.9e-05 24.2 1.8 0.096 12.2 0.0 2.8 3 0 0 3 3 2 2 P-loop containing dynein motor region T2SSE PF00437.20 EFC43666.1 - 5.5e-05 22.4 0.6 0.011 14.8 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 EFC43666.1 - 8.2e-05 22.4 0.1 0.089 12.5 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein ABC_tran PF00005.27 EFC43666.1 - 8.8e-05 23.0 0.9 0.057 13.9 0.1 2.9 3 0 0 3 3 2 1 ABC transporter TIP49 PF06068.13 EFC43666.1 - 0.0001 21.6 0.1 0.21 10.7 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain ATPase PF06745.13 EFC43666.1 - 0.00023 20.6 3.5 0.44 9.9 0.0 3.4 2 1 1 3 3 3 2 KaiC AAA_25 PF13481.6 EFC43666.1 - 0.00029 20.5 3.7 0.24 11.0 0.6 3.4 4 0 0 4 4 3 2 AAA domain AAA_14 PF13173.6 EFC43666.1 - 0.00047 20.2 1.1 0.9 9.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain PhoH PF02562.16 EFC43666.1 - 0.00053 19.5 0.1 0.7 9.3 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein IPT PF01745.16 EFC43666.1 - 0.0007 19.1 0.6 0.0067 15.8 0.1 2.6 2 0 0 2 2 2 1 Isopentenyl transferase AAA_30 PF13604.6 EFC43666.1 - 0.0015 18.3 0.1 0.97 9.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 EFC43666.1 - 0.0015 18.9 0.2 0.78 10.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EFC43666.1 - 0.0019 18.1 1.1 1.6 8.6 0.0 3.4 3 1 1 4 4 3 1 Rad17 P-loop domain AAA_3 PF07726.11 EFC43666.1 - 0.0029 17.4 0.0 0.53 10.2 0.0 2.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 EFC43666.1 - 0.0042 16.4 1.3 1.4 8.0 0.0 2.9 3 1 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) Torsin PF06309.11 EFC43666.1 - 0.0047 17.0 0.1 0.47 10.6 0.0 2.7 2 0 0 2 2 2 1 Torsin Zeta_toxin PF06414.12 EFC43666.1 - 0.0048 16.2 0.1 0.2 10.9 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 EFC43666.1 - 0.0057 15.9 0.1 1.8 7.7 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain NACHT PF05729.12 EFC43666.1 - 0.0064 16.4 6.6 2.6 7.9 0.1 4.4 4 1 1 5 5 5 1 NACHT domain ResIII PF04851.15 EFC43666.1 - 0.0078 16.2 4.0 1.6 8.7 0.1 3.6 3 1 1 4 4 3 1 Type III restriction enzyme, res subunit AAA_17 PF13207.6 EFC43666.1 - 0.0082 16.6 0.3 3.8 7.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain SKI PF01202.22 EFC43666.1 - 0.01 16.0 0.1 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase CbiA PF01656.23 EFC43666.1 - 0.012 15.6 1.5 0.24 11.5 0.5 3.2 3 0 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 EFC43666.1 - 0.021 14.5 0.5 0.68 9.5 0.1 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain CDC48_N PF02359.18 EFC43666.1 - 0.023 14.8 0.0 0.073 13.2 0.0 1.9 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain TniB PF05621.11 EFC43666.1 - 0.032 13.6 0.2 3.8 6.9 0.0 3.3 3 0 0 3 3 3 0 Bacterial TniB protein TrwB_AAD_bind PF10412.9 EFC43666.1 - 0.039 12.9 0.5 0.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain PduV-EutP PF10662.9 EFC43666.1 - 0.043 13.5 2.4 4.7 7.0 0.0 3.4 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Cytidylate_kin PF02224.18 EFC43666.1 - 0.062 13.0 0.1 8.3 6.1 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase Sigma54_activ_2 PF14532.6 EFC43666.1 - 0.065 13.4 0.1 12 6.0 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain KTI12 PF08433.10 EFC43666.1 - 0.078 12.4 0.0 1.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 DEAD PF00270.29 EFC43666.1 - 0.13 12.0 1.2 9.7 5.9 0.0 3.3 2 1 1 3 3 3 0 DEAD/DEAH box helicase APS_kinase PF01583.20 EFC43666.1 - 0.13 12.1 0.1 8.5 6.2 0.1 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_29 PF13555.6 EFC43666.1 - 0.23 11.3 2.1 2.5 7.9 0.3 2.9 3 0 0 3 3 2 0 P-loop containing region of AAA domain Glyco_hydro_31 PF01055.26 EFC43667.1 - 3.7e-143 477.9 4.8 5.1e-143 477.4 4.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFC43667.1 - 7.4e-14 51.8 2.2 2.7e-13 50.0 2.2 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like NtCtMGAM_N PF16863.5 EFC43667.1 - 0.0051 17.0 0.2 0.017 15.3 0.2 2.0 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gsf2 PF11055.8 EFC43667.1 - 0.059 12.1 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 Glucose signalling factor 2 DEAD PF00270.29 EFC43668.1 - 8.4e-44 149.4 0.8 2.6e-43 147.8 0.3 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC43668.1 - 1.7e-29 102.4 0.5 2.1e-28 98.9 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EFC43668.1 - 9.3e-05 22.8 0.1 0.003 17.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain CMS1 PF14617.6 EFC43668.1 - 0.0067 15.8 0.1 0.0067 15.8 0.1 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.6 EFC43668.1 - 0.0078 16.0 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain tRNA-synt_1b PF00579.25 EFC43668.1 - 0.075 12.3 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Helicase_RecD PF05127.14 EFC43668.1 - 0.089 12.6 0.0 0.21 11.4 0.0 1.6 2 0 0 2 2 2 0 Helicase AAA_22 PF13401.6 EFC43668.1 - 0.092 13.0 0.4 0.64 10.3 0.4 2.3 1 1 0 1 1 1 0 AAA domain CDC37_C PF08564.10 EFC43668.1 - 0.11 12.6 0.0 7.3 6.8 0.0 2.8 2 0 0 2 2 2 0 Cdc37 C terminal domain Pullulanase_Ins PF18494.1 EFC43668.1 - 0.36 11.3 2.8 0.29 11.6 0.8 1.9 2 0 0 2 2 2 0 Pullulanase Ins domain Histone PF00125.24 EFC43669.1 - 0.0031 17.9 5.7 0.0057 17.0 5.7 1.6 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Chromo PF00385.24 EFC43670.1 - 8.6e-10 38.4 0.2 2.8e-09 36.8 0.2 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Phage_integrase PF00589.22 EFC43670.1 - 0.26 11.1 1.3 1.1 9.0 0.3 2.7 2 1 1 3 3 3 0 Phage integrase family CitMHS PF03600.16 EFC43671.1 - 1.2e-28 100.2 0.0 7.6e-28 97.6 0.0 1.9 1 1 1 2 2 2 1 Citrate transporter ICL PF00463.21 EFC43671.1 - 0.042 12.4 0.1 0.075 11.5 0.1 1.3 1 0 0 1 1 1 0 Isocitrate lyase family TrkA_C PF02080.21 EFC43671.1 - 0.2 11.5 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 TrkA-C domain ANAPC3 PF12895.7 EFC43672.1 - 0.0046 17.1 0.5 0.01 16.0 0.5 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF948 PF06103.11 EFC43672.1 - 0.027 14.7 0.8 1.3 9.3 0.0 3.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TPR_19 PF14559.6 EFC43672.1 - 0.038 14.5 0.0 0.084 13.4 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Big_2 PF02368.18 EFC43673.1 - 3.1e-15 55.8 14.8 2e-05 24.4 6.6 6.9 7 0 0 7 7 7 4 Bacterial Ig-like domain (group 2) T2SS-T3SS_pil_N PF13629.6 EFC43673.1 - 0.00049 19.8 4.5 15 5.4 0.0 6.3 7 0 0 7 7 7 1 Pilus formation protein N terminal region BppU_N PF10651.9 EFC43673.1 - 0.05 13.3 0.3 0.22 11.2 0.0 2.3 2 0 0 2 2 2 0 BppU N-terminal domain Rol_Rep_N PF18106.1 EFC43673.1 - 0.092 13.1 0.1 0.32 11.3 0.1 1.9 1 0 0 1 1 1 0 Rolling Circle replication initiation protein N-terminal domain Pkinase PF00069.25 EFC43674.1 - 3.9e-58 196.9 2.2 4.4e-58 196.7 2.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43674.1 - 1.1e-32 113.4 0.2 1.5e-32 112.9 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43674.1 - 1.3e-07 30.8 0.0 2.6e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFC43674.1 - 0.00092 18.8 1.3 0.0014 18.1 0.2 1.8 2 1 0 2 2 2 1 PhoP regulatory network protein YrbL Kdo PF06293.14 EFC43674.1 - 0.0055 16.1 0.1 0.012 15.0 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC43674.1 - 0.0056 16.0 0.1 0.024 14.0 0.1 2.1 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 EFC43674.1 - 0.0062 16.1 1.3 0.0078 15.8 0.1 1.8 2 0 0 2 2 2 1 RIO1 family DUF4116 PF13475.6 EFC43674.1 - 0.018 14.8 0.3 0.085 12.6 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) APH PF01636.23 EFC43674.1 - 0.23 11.4 0.0 0.34 10.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Enkurin PF13864.6 EFC43675.1 - 3.8e-24 85.0 11.4 3.8e-24 85.0 11.4 3.1 2 1 0 2 2 2 1 Calmodulin-binding MgsA_C PF12002.8 EFC43675.1 - 9.1 6.2 14.2 13 5.7 4.5 2.8 2 1 0 2 2 2 0 MgsA AAA+ ATPase C terminal Ferritin PF00210.24 EFC43677.1 - 9.3e-28 96.9 1.8 3.3e-27 95.2 1.8 1.7 1 1 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 EFC43677.1 - 0.00035 21.0 0.2 0.00052 20.4 0.2 1.3 1 1 0 1 1 1 1 Rubrerythrin UPF0242 PF06785.11 EFC43678.1 - 2 8.4 8.4 55 3.8 6.0 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus RCC1 PF00415.18 EFC43679.1 - 5.7e-22 78.1 6.8 0.0044 17.6 0.0 6.6 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43679.1 - 2.4e-19 68.6 21.3 1.4e-07 31.1 0.0 7.2 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC43679.1 - 0.006 16.8 0.1 2.8 8.2 0.0 2.8 2 1 0 2 2 2 2 Putative heavy-metal chelation SUKH-3 PF14433.6 EFC43679.1 - 0.17 12.4 0.7 0.53 10.7 0.0 2.1 3 0 0 3 3 3 0 SUKH-3 immunity protein LRR_4 PF12799.7 EFC43680.1 - 0.00058 20.2 3.5 0.0013 19.1 3.5 1.6 1 0 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC43680.1 - 0.022 14.8 1.6 5.5 7.3 0.0 2.9 2 0 0 2 2 2 0 Leucine Rich repeat LRR_8 PF13855.6 EFC43680.1 - 0.53 10.1 5.6 2 8.3 4.2 2.5 2 1 0 2 2 2 0 Leucine rich repeat LRR_1 PF00560.33 EFC43680.1 - 3.6 8.5 5.1 1.7 9.5 0.4 2.9 3 1 0 3 3 3 0 Leucine Rich Repeat Ank_2 PF12796.7 EFC43681.1 - 1.3e-19 70.6 0.4 8.1e-19 68.0 0.2 2.0 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC43681.1 - 2.5e-19 69.4 0.1 8.7e-10 38.9 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC43681.1 - 1.7e-17 63.0 0.0 7e-07 29.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFC43681.1 - 1.9e-15 56.7 0.2 2.4e-07 30.9 0.0 2.6 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC43681.1 - 4.9e-13 48.0 0.0 0.0001 22.4 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat CheD PF03975.13 EFC43681.1 - 0.16 12.0 0.0 5.3 7.2 0.0 2.2 2 0 0 2 2 2 0 CheD chemotactic sensory transduction Cupin_8 PF13621.6 EFC43682.1 - 2.4e-40 138.9 1.1 3.3e-40 138.4 1.1 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EFC43682.1 - 1.8e-13 50.7 0.2 2.4e-12 47.0 0.2 2.2 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EFC43682.1 - 0.00066 20.1 0.2 0.0021 18.5 0.1 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase RIO1 PF01163.22 EFC43683.1 - 5.1e-68 228.4 0.2 5.1e-68 228.4 0.2 1.6 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 EFC43683.1 - 0.0033 16.8 1.2 0.048 13.0 0.3 2.8 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFC43683.1 - 0.0068 15.8 0.9 0.014 14.8 0.2 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC43683.1 - 0.026 13.3 0.0 0.026 13.3 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase REJ PF02010.15 EFC43684.1 - 6e-37 127.5 5.0 6e-37 127.5 5.0 3.0 3 1 0 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC43684.1 - 1.8e-28 98.5 297.0 7.4e-05 23.0 5.4 20.2 19 1 0 19 19 19 14 EGF-like domain EGF PF00008.27 EFC43684.1 - 0.00061 20.0 3.0 0.00061 20.0 3.0 18.5 19 1 0 19 19 19 9 EGF-like domain TcfC PF16967.5 EFC43684.1 - 0.015 14.8 0.2 0.44 10.1 0.0 2.4 2 0 0 2 2 2 0 E-set like domain F-box-like PF12937.7 EFC43687.1 - 0.00018 21.3 0.3 0.00018 21.3 0.3 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 EFC43687.1 - 0.0006 19.6 0.5 0.0006 19.6 0.5 3.7 4 0 0 4 4 4 1 F-box domain LRR_8 PF13855.6 EFC43687.1 - 0.073 12.8 1.9 1.2 9.0 0.0 3.7 3 1 1 4 4 4 0 Leucine rich repeat MJ1316 PF04457.12 EFC43688.1 - 1e-07 32.6 0.1 2e-07 31.6 0.1 1.5 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Turandot PF07240.11 EFC43688.1 - 0.046 13.7 0.7 3 7.9 0.0 2.9 3 1 0 3 3 3 0 Stress-inducible humoral factor Turandot KdpC PF02669.15 EFC43688.1 - 0.13 12.0 0.4 0.25 11.2 0.4 1.4 1 0 0 1 1 1 0 K+-transporting ATPase, c chain Nore1-SARAH PF16517.5 EFC43688.1 - 6 6.9 12.6 0.77 9.7 0.8 2.4 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain Peptidase_M16_C PF05193.21 EFC43690.1 - 9.6e-15 55.1 0.0 9.2e-12 45.3 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFC43690.1 - 1.1e-08 35.2 0.0 2e-07 31.1 0.0 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) ARGLU PF15346.6 EFC43690.1 - 0.02 14.8 8.5 0.016 15.1 6.4 1.8 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 p450 PF00067.22 EFC43691.1 - 2e-39 135.6 1.3 2.3e-37 128.8 1.3 2.2 1 1 0 1 1 1 1 Cytochrome P450 CdiA_C_tRNase PF18664.1 EFC43691.1 - 0.45 10.7 1.6 2.2 8.5 0.3 2.4 1 1 0 2 2 2 0 CdiA C-terminal tRNase domain AMP-binding PF00501.28 EFC43692.1 - 6.4e-30 104.1 0.0 7.7e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme NHL PF01436.21 EFC43693.1 - 0.002 18.1 0.1 0.0079 16.2 0.1 2.1 1 0 0 1 1 1 1 NHL repeat Polysacc_deac_1 PF01522.21 EFC43694.1 - 7.9e-11 41.9 0.0 3.3e-10 39.9 0.0 1.9 1 1 0 1 1 1 1 Polysaccharide deacetylase DUF4834 PF16118.5 EFC43694.1 - 0.0028 18.6 0.2 0.0062 17.5 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Polysacc_deac_2 PF04748.13 EFC43694.1 - 0.016 14.4 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase MASE1 PF05231.14 EFC43695.1 - 0.051 12.7 0.0 0.087 12.0 0.0 1.3 1 0 0 1 1 1 0 MASE1 PigN PF04987.14 EFC43696.1 - 3.5e-119 398.7 46.8 4.5e-119 398.3 46.8 1.1 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Sulfatase PF00884.23 EFC43696.1 - 2.5e-09 37.0 0.0 5.6e-09 35.8 0.0 1.7 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 EFC43696.1 - 2.7e-08 33.8 0.7 4.9e-07 29.7 0.8 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EFC43696.1 - 2.9e-06 26.8 0.0 5.8e-06 25.8 0.0 1.4 1 1 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 EFC43696.1 - 0.00058 20.0 0.5 0.059 13.5 0.2 2.4 2 0 0 2 2 2 1 PglZ domain Mononeg_mRNAcap PF14318.6 EFC43697.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V DUF4116 PF13475.6 EFC43698.1 - 3.5e-28 97.1 38.0 9.4e-09 34.9 0.1 9.8 7 3 1 8 8 8 7 Domain of unknown function (DUF4116) LigB PF02900.18 EFC43700.1 - 2.2e-44 151.6 0.0 2.9e-44 151.2 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DNA_pol_viral_N PF00242.17 EFC43700.1 - 0.15 11.5 0.0 0.22 11.0 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) N-terminal domain MIP-T3_C PF17749.1 EFC43702.1 - 0.05 13.6 0.2 0.05 13.6 0.2 2.2 2 1 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region TMF_TATA_bd PF12325.8 EFC43703.1 - 3.9e-06 27.1 14.5 3.9e-06 27.1 14.5 7.1 1 1 5 6 6 6 1 TATA element modulatory factor 1 TATA binding HOOK PF05622.12 EFC43703.1 - 0.37 8.9 115.6 3.9 5.5 93.3 2.3 1 1 1 2 2 2 0 HOOK protein Surfac_D-trimer PF09006.11 EFC43703.1 - 1.2 9.1 5.0 44 4.1 0.4 4.1 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation zf-CCCH_6 PF18585.1 EFC43703.1 - 2.7 7.9 5.1 2.4 8.1 0.2 3.8 2 1 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 GAS PF13851.6 EFC43703.1 - 2.8 7.3 128.9 1.2 8.4 18.3 4.8 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Filament PF00038.21 EFC43703.1 - 8.6 5.8 116.1 4.3 6.8 48.6 4.9 1 1 1 3 3 3 0 Intermediate filament protein ETC_C1_NDUFA4 PF04800.12 EFC43704.1 - 9.3e-30 102.7 0.2 1.3e-29 102.3 0.2 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Vac14_Fab1_bd PF12755.7 EFC43705.1 - 3.6e-07 30.7 1.7 0.15 12.7 0.0 4.9 5 0 0 5 5 5 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFC43705.1 - 9.8e-05 22.0 2.9 9.8e-05 22.0 2.9 5.2 6 1 1 7 7 7 2 CLASP N terminal MMS19_N PF14500.6 EFC43705.1 - 0.018 14.6 6.0 7.4 6.1 0.0 4.7 3 1 1 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II ParcG PF10274.9 EFC43705.1 - 0.075 13.2 0.4 0.39 10.8 0.1 2.4 2 0 0 2 2 2 0 Parkin co-regulated protein RTP1_C1 PF10363.9 EFC43705.1 - 0.078 13.2 0.7 3.6 7.8 0.0 3.5 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 TAN PF11640.8 EFC43705.1 - 0.28 11.3 0.0 0.28 11.3 0.0 5.6 5 1 0 5 5 5 0 Telomere-length maintenance and DNA damage repair Ndc1_Nup PF09531.10 EFC43706.1 - 0.14 10.8 4.9 0.35 9.5 4.9 1.8 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup VRR_NUC PF08774.11 EFC43708.1 - 3e-21 75.5 0.1 8.9e-21 74.0 0.1 1.9 1 0 0 1 1 1 1 VRR-NUC domain DUF4980 PF16352.5 EFC43708.1 - 0.01 15.8 0.3 0.043 13.8 0.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4980) NUP214 PF16755.5 EFC43709.1 - 0.0074 15.6 0.1 0.0079 15.5 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 LRR_6 PF13516.6 EFC43710.1 - 3.9e-08 32.7 29.2 0.025 14.6 0.2 8.9 9 0 0 9 9 9 3 Leucine Rich repeat LRR_4 PF12799.7 EFC43710.1 - 1.3e-06 28.6 34.6 0.0037 17.7 0.6 6.3 3 2 3 6 6 6 4 Leucine Rich repeats (2 copies) DUF3557 PF12078.8 EFC43710.1 - 0.0012 18.8 0.8 0.0012 18.8 0.8 2.6 3 1 0 3 3 3 1 Domain of unknown function (DUF3557) LRR_8 PF13855.6 EFC43710.1 - 0.0043 16.8 29.5 0.0069 16.1 1.7 6.3 3 2 2 5 5 5 2 Leucine rich repeat FAM176 PF14851.6 EFC43710.1 - 0.51 10.0 4.3 1.5 8.5 4.3 1.7 1 0 0 1 1 1 0 FAM176 family LRR_2 PF07723.13 EFC43710.1 - 6.9 7.5 13.2 12 6.8 0.2 5.2 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_1 PF00560.33 EFC43710.1 - 9.8 7.2 30.1 2.1 9.2 0.3 7.8 7 3 0 7 7 7 0 Leucine Rich Repeat F-box-like PF12937.7 EFC43711.1 - 7.9e-05 22.5 1.3 0.00014 21.7 0.2 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC43711.1 - 0.0049 16.7 0.2 0.017 15.0 0.2 2.0 1 1 0 1 1 1 1 F-box domain F-box_5 PF18511.1 EFC43711.1 - 0.04 13.5 0.9 0.095 12.3 0.9 1.6 1 0 0 1 1 1 0 F-box Antimicrobial20 PF08256.11 EFC43711.1 - 0.16 12.5 0.9 0.16 12.5 0.9 3.3 3 0 0 3 3 3 0 Aurein-like antibiotic peptide ASF1_hist_chap PF04729.13 EFC43712.1 - 2.5e-57 193.1 0.5 2.8e-57 193.0 0.5 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone UPF0154 PF03672.13 EFC43712.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0154) TPR_1 PF00515.28 EFC43713.1 - 5.9e-06 25.9 1.3 0.1 12.5 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC43713.1 - 3.8e-05 23.5 1.5 0.25 11.5 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC43713.1 - 0.00071 19.4 1.1 1.8 8.7 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC43713.1 - 0.028 14.7 1.3 8.9 6.7 0.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43713.1 - 0.047 13.9 2.9 1.2 9.5 0.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2208 PF09973.9 EFC43713.1 - 0.063 12.9 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) AbfS_sensor PF18225.1 EFC43714.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Sensor histidine kinase (AbfS) sensor domain Pkinase PF00069.25 EFC43715.1 - 4.4e-35 121.3 2.1 5.8e-35 120.9 2.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43715.1 - 7.9e-28 97.4 0.5 1.1e-27 97.0 0.5 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43715.1 - 0.00019 20.4 0.0 0.00027 19.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFC43715.1 - 0.009 15.6 0.0 0.017 14.6 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL ASFV_L11L PF05293.11 EFC43715.1 - 0.13 12.6 0.7 0.57 10.6 0.0 2.3 2 1 1 3 3 3 0 African swine fever virus (ASFV) L11L protein MFS_MOT1 PF16983.5 EFC43716.1 - 0.15 12.5 0.1 0.37 11.2 0.0 1.6 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily DUF676 PF05057.14 EFC43717.1 - 1.9e-40 138.7 0.0 3.5e-40 137.9 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFC43717.1 - 2.4e-05 24.2 0.2 0.00019 21.3 0.2 2.2 1 1 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 EFC43717.1 - 6.7e-05 22.8 0.2 0.00018 21.5 0.0 1.8 2 0 0 2 2 2 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 EFC43717.1 - 0.00033 20.5 0.0 0.00066 19.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Sigma70_ner PF04546.13 EFC43717.1 - 0.028 14.3 1.4 0.04 13.8 1.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Abhydrolase_6 PF12697.7 EFC43717.1 - 0.044 14.4 0.0 0.058 14.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cytokin_check_N PF10407.9 EFC43717.1 - 0.082 12.9 1.2 0.22 11.5 0.4 2.2 2 0 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus Hydrolase_4 PF12146.8 EFC43717.1 - 0.12 11.7 0.0 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF2120 PF09893.9 EFC43717.1 - 1.4 9.0 4.3 2.2 8.4 3.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Pkinase PF00069.25 EFC43718.1 - 5.1e-49 167.0 0.2 6.4e-49 166.7 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43718.1 - 1.7e-32 112.7 0.1 2.1e-32 112.5 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43718.1 - 6.9e-06 25.6 0.0 0.0034 16.7 0.0 2.2 1 1 1 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 EFC43718.1 - 0.0029 16.6 0.3 0.0041 16.1 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC43718.1 - 0.057 12.2 1.1 2.5 6.8 0.0 2.1 1 1 0 2 2 2 0 Fungal protein kinase APH PF01636.23 EFC43718.1 - 0.12 12.3 0.0 4.7 7.0 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family LRR_6 PF13516.6 EFC43720.1 - 3.6e-45 148.2 36.9 0.00012 21.8 0.2 15.0 14 1 0 14 14 14 11 Leucine Rich repeat LRR_4 PF12799.7 EFC43720.1 - 1e-07 32.1 26.9 0.0022 18.3 2.3 6.9 5 2 2 7 7 7 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC43720.1 - 2.9e-07 30.1 10.6 4 8.4 0.0 9.7 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_2 PF07723.13 EFC43720.1 - 0.0007 20.1 8.0 2 9.2 0.0 6.2 7 0 0 7 7 7 1 Leucine Rich Repeat Lipase PF00151.19 EFC43720.1 - 0.57 9.4 4.5 0.25 10.6 2.1 1.6 2 0 0 2 2 2 0 Lipase LRR_8 PF13855.6 EFC43720.1 - 6.8 6.5 35.6 0.99 9.2 2.7 8.8 6 2 3 9 9 9 0 Leucine rich repeat Tfb5 PF06331.12 EFC43720.1 - 8.6 6.4 8.4 3.1 7.8 0.3 3.8 3 1 1 4 4 4 0 Transcription factor TFIIH complex subunit Tfb5 Beta_helix PF13229.6 EFC43721.1 - 7.7e-51 172.1 58.3 4.4e-20 72.1 14.3 5.1 3 1 3 6 6 6 4 Right handed beta helix region NosD PF05048.13 EFC43721.1 - 1.4e-33 116.2 68.2 5.6e-14 52.0 16.6 4.8 2 1 4 6 6 6 5 Periplasmic copper-binding protein (NosD) Disaggr_assoc PF08480.10 EFC43721.1 - 0.0032 17.4 0.4 0.0032 17.4 0.4 5.7 4 3 2 6 6 6 1 Disaggregatase related DUF295 PF03478.18 EFC43721.1 - 0.062 12.9 0.9 0.61 9.7 0.0 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF295) Pectate_lyase_3 PF12708.7 EFC43721.1 - 0.18 11.6 20.4 0.12 12.2 3.3 4.2 1 1 4 5 5 5 0 Pectate lyase superfamily protein Lig_chan PF00060.26 EFC43723.1 - 3.6e-32 111.2 0.8 5.9e-32 110.6 0.8 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 EFC43723.1 - 3.5e-26 92.0 0.0 7.7e-25 87.6 0.0 2.1 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 EFC43723.1 - 9.6e-23 80.6 0.0 1.9e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site DUF3139 PF11337.8 EFC43723.1 - 0.059 14.0 2.9 14 6.4 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Wzy_C PF04932.15 EFC43723.1 - 0.071 12.7 2.2 0.82 9.3 0.2 2.5 2 1 0 2 2 2 0 O-Antigen ligase Ni_hydr_CYTB PF01292.20 EFC43723.1 - 0.098 12.2 1.9 0.13 11.8 0.2 1.8 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 DUF4834 PF16118.5 EFC43723.1 - 0.28 12.2 4.6 2.4 9.2 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Pkinase PF00069.25 EFC43724.1 - 8.5e-72 241.7 0.0 1.1e-71 241.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43724.1 - 8.7e-34 117.0 0.0 1.2e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43724.1 - 0.00022 20.7 0.2 0.0025 17.2 0.0 2.4 3 0 0 3 3 3 1 Kinase-like FTA2 PF13095.6 EFC43724.1 - 0.0039 16.8 0.5 0.045 13.4 0.2 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EFC43724.1 - 0.038 12.9 0.1 0.038 12.9 0.1 1.5 2 0 0 2 2 2 0 Haspin like kinase domain ATPgrasp_YheCD PF14398.6 EFC43724.1 - 0.038 13.2 0.2 0.082 12.1 0.2 1.5 1 0 0 1 1 1 0 YheC/D like ATP-grasp Cyclin_N PF00134.23 EFC43725.1 - 2.1e-06 27.5 1.3 5.3e-06 26.2 1.3 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF4116 PF13475.6 EFC43726.1 - 1.6e-31 107.8 11.4 7.2e-18 64.1 0.4 5.0 2 2 3 5 5 5 5 Domain of unknown function (DUF4116) DUF1304 PF06993.12 EFC43727.1 - 2.4e-41 140.1 5.0 2.8e-41 140.0 5.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1304) Josephin PF02099.17 EFC43728.1 - 2.9e-35 121.8 1.8 4.7e-35 121.1 1.8 1.3 1 0 0 1 1 1 1 Josephin Mucin2_WxxW PF13330.6 EFC43728.1 - 0.13 13.1 0.9 0.3 11.9 0.0 2.1 2 0 0 2 2 2 0 Mucin-2 protein WxxW repeating region EIF4E-T PF10477.9 EFC43728.1 - 0.19 10.5 6.8 1.6 7.4 6.8 2.0 1 1 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E NAD_binding_4 PF07993.12 EFC43729.1 - 3.6e-50 170.5 0.0 5.9e-50 169.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 EFC43729.1 - 2.2e-42 145.2 0.0 4.6e-42 144.1 0.0 1.5 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 EFC43729.1 - 1.6e-14 54.0 0.0 3e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC43729.1 - 4.8e-13 49.2 0.2 4.8e-13 49.2 0.2 1.9 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC43729.1 - 4.7e-07 29.1 0.6 1.1e-06 27.9 0.1 1.8 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 EFC43729.1 - 3.7e-05 23.7 0.0 7.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 KR domain PP-binding PF00550.25 EFC43729.1 - 0.0011 19.3 0.0 0.003 17.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 EFC43729.1 - 0.0038 16.4 0.1 0.013 14.6 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Rif1_N PF12231.8 EFC43729.1 - 0.065 12.2 1.0 0.13 11.3 1.0 1.4 1 0 0 1 1 1 0 Rap1-interacting factor 1 N terminal PCRF PF03462.18 EFC43729.1 - 0.072 13.0 0.2 0.24 11.2 0.2 1.9 1 0 0 1 1 1 0 PCRF domain NAD_binding_10 PF13460.6 EFC43729.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 NAD(P)H-binding NlpE PF04170.12 EFC43729.1 - 0.2 12.6 0.7 6.2 7.9 0.0 3.1 3 0 0 3 3 3 0 NlpE N-terminal domain SRP19 PF01922.17 EFC43730.1 - 1.4e-25 90.0 0.2 1.6e-25 89.9 0.2 1.0 1 0 0 1 1 1 1 SRP19 protein Pre-PUA PF17832.1 EFC43731.1 - 1.4e-22 80.2 0.0 1.9e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 EFC43731.1 - 7.9e-17 61.0 0.2 1.2e-16 60.4 0.2 1.3 1 0 0 1 1 1 1 PUA domain Polyoma_lg_T_C PF06431.11 EFC43731.1 - 0.16 10.8 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus Ribosom_S12_S23 PF00164.25 EFC43732.1 - 6.4e-50 167.6 0.5 8.2e-50 167.2 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF4539 PF15072.6 EFC43733.1 - 5.7e-19 67.9 0.2 9.8e-19 67.2 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4539) HTH_19 PF12844.7 EFC43734.1 - 0.024 14.6 1.6 2.5 8.2 0.1 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain PAW PF04721.17 EFC43737.1 - 0.0022 17.8 0.3 0.0022 17.8 0.3 2.0 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW Arm-DNA-bind_5 PF17293.2 EFC43737.1 - 0.5 10.8 9.9 0.15 12.5 3.0 2.8 2 0 0 2 2 2 0 Arm DNA-binding domain PhoU PF01895.19 EFC43737.1 - 1.5 9.3 4.8 0.6 10.6 1.2 2.2 3 0 0 3 3 3 0 PhoU domain LSM PF01423.22 EFC43738.1 - 4.9e-17 61.4 1.3 4.9e-17 61.4 1.3 1.5 2 0 0 2 2 2 1 LSM domain Hfq PF17209.3 EFC43738.1 - 0.071 12.8 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Hfq protein BP28CT PF08146.12 EFC43739.1 - 1.7e-31 109.2 0.4 1.7e-31 109.2 0.4 4.2 4 0 0 4 4 4 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 EFC43739.1 - 3.7e-20 72.4 1.2 3.7e-20 72.4 1.2 7.5 7 2 1 9 9 9 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 EFC43739.1 - 4.2e-05 23.5 1.2 5.8 7.5 0.1 5.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 EFC43739.1 - 0.0023 18.3 0.5 26 5.3 0.1 5.2 5 0 0 5 5 5 0 HEAT repeats HEAT_EZ PF13513.6 EFC43739.1 - 0.0082 16.6 0.1 86 3.8 0.0 6.2 7 0 0 7 7 7 0 HEAT-like repeat Nucleocap_ssRNA PF11128.8 EFC43739.1 - 0.055 13.2 0.1 0.16 11.7 0.1 1.7 1 0 0 1 1 1 0 Plant viral coat protein nucleocapsid Imm70 PF15601.6 EFC43739.1 - 0.13 11.8 1.1 17 4.9 0.1 3.3 2 0 0 2 2 2 0 Immunity protein 70 RTP1_C1 PF10363.9 EFC43739.1 - 1.6 9.0 19.6 0.14 12.3 0.6 6.1 6 1 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 PARP PF00644.20 EFC43740.1 - 2.9e-12 46.6 0.1 5.7e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain RSN1_7TM PF02714.15 EFC43742.1 - 3.1e-35 121.8 26.7 3.1e-35 121.8 26.7 2.1 1 1 1 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 EFC43742.1 - 2.3e-11 44.2 0.9 2.3e-11 44.2 0.9 2.0 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 EFC43742.1 - 8.3e-05 22.4 2.9 8.3e-05 22.4 2.9 3.8 4 1 0 4 4 4 2 Late exocytosis, associated with Golgi transport DUF919 PF06034.11 EFC43742.1 - 0.033 14.0 1.2 0.065 13.1 0.1 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Peroxin-3 PF04882.12 EFC43744.1 - 6.6e-38 130.9 5.8 2.3e-30 106.0 3.2 2.1 1 1 1 2 2 2 2 Peroxin-3 PAP_PilO PF06864.12 EFC43744.1 - 0.19 10.5 0.7 0.96 8.2 0.1 2.0 1 1 1 2 2 2 0 Pilin accessory protein (PilO) Beach PF02138.18 EFC43745.1 - 9.3e-123 409.0 0.5 1.8e-122 408.0 0.5 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 EFC43745.1 - 2.2e-12 46.9 0.1 7.5e-12 45.2 0.1 2.0 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 EFC43745.1 - 1.2e-08 35.3 1.0 1.2e-07 32.0 1.0 2.4 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 EFC43745.1 - 2.1e-05 23.9 1.8 5.8e-05 22.5 1.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) WD40 PF00400.32 EFC43745.1 - 0.0014 19.4 2.9 2.2 9.3 0.1 4.3 3 0 0 3 3 3 1 WD domain, G-beta repeat Laminin_G_2 PF02210.24 EFC43745.1 - 0.1 13.2 0.0 0.35 11.5 0.0 1.9 1 0 0 1 1 1 0 Laminin G domain Helicase_C_2 PF13307.6 EFC43746.1 - 4.8e-55 186.3 0.0 1.1e-54 185.2 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFC43746.1 - 1.7e-45 154.8 3.8 4.3e-45 153.5 1.1 2.5 2 0 0 2 2 2 1 DEAD_2 HBB PF06777.11 EFC43746.1 - 0.012 15.3 0.1 0.042 13.5 0.0 1.9 3 0 0 3 3 3 0 Helical and beta-bridge domain ResIII PF04851.15 EFC43746.1 - 0.019 15.0 0.1 0.95 9.4 0.1 2.5 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit DUF3958 PF13125.6 EFC43746.1 - 0.079 13.2 0.2 0.3 11.3 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) PhoLip_ATPase_C PF16212.5 EFC43747.1 - 2.6e-67 227.2 29.1 2.6e-67 227.2 29.1 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 EFC43747.1 - 2.2e-10 41.2 0.1 6.5e-05 23.3 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC43747.1 - 4.2e-07 30.0 0.7 1.9e-05 24.7 0.1 3.5 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC43747.1 - 0.0019 18.0 2.4 0.0019 18.0 2.4 3.7 4 1 1 5 5 5 1 haloacid dehalogenase-like hydrolase Response_reg PF00072.24 EFC43748.1 - 1.1e-17 64.2 0.2 1.2e-17 64.1 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain AAA-ATPase_like PF09820.9 EFC43749.1 - 0.0022 17.5 0.2 0.0022 17.5 0.2 2.3 3 0 0 3 3 3 1 Predicted AAA-ATPase DUF1912 PF08930.10 EFC43749.1 - 0.12 12.5 1.0 4.2 7.6 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) ASH PF15780.5 EFC43750.1 - 6e-34 116.2 27.9 1.8e-08 34.4 0.0 11.0 11 1 0 11 11 11 7 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 EFC43750.1 - 6.6e-11 42.3 0.4 0.081 13.1 0.0 5.6 5 0 0 5 5 5 3 Flagellar-associated PapD-like MYCBPAP PF14646.6 EFC43750.1 - 2.8e-08 33.1 12.2 0.74 8.7 0.0 6.1 5 0 0 5 5 5 5 MYCBP-associated protein family Motile_Sperm PF00635.26 EFC43750.1 - 6.1e-08 32.5 25.7 4.1e-05 23.4 0.4 8.8 8 0 0 8 8 8 3 MSP (Major sperm protein) domain DUF1573 PF07610.11 EFC43750.1 - 1.4e-07 31.4 12.5 0.0093 16.0 0.1 6.7 8 0 0 8 8 8 2 Protein of unknown function (DUF1573) TMEM131_like PF12371.8 EFC43750.1 - 4.4e-05 23.6 11.8 2.4 8.5 0.0 8.0 9 0 0 9 9 9 2 Transmembrane protein 131-like HBD PF18534.1 EFC43750.1 - 0.12 12.5 2.3 0.8 9.9 0.0 3.0 3 0 0 3 3 3 0 Helical bundle domain EF-hand_1 PF00036.32 EFC43751.1 - 5.1e-07 28.8 1.1 0.0001 21.6 0.1 3.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EFC43751.1 - 3.5e-06 27.4 1.8 0.0016 18.8 0.1 3.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EFC43751.1 - 0.00063 19.5 0.3 0.59 10.0 0.3 3.2 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC43751.1 - 0.0032 17.3 1.1 0.57 10.3 0.1 3.7 4 0 0 4 4 4 1 EF-hand domain FAM219A PF15260.6 EFC43751.1 - 0.093 13.1 1.5 0.27 11.6 0.2 2.6 1 1 1 2 2 2 0 Protein family FAM219A IZUMO PF15005.6 EFC43751.1 - 0.13 12.8 0.4 36 4.8 0.0 3.1 2 1 1 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Trypan_PARP PF05887.11 EFC43752.1 - 3.4e-06 27.1 102.0 1.8e+04 -44.3 102.0 3.0 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) LRR_6 PF13516.6 EFC43753.1 - 7.5e-11 41.2 20.5 4.1e-05 23.3 0.2 6.9 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 EFC43753.1 - 2.2e-09 37.4 27.8 0.0028 18.0 1.0 5.9 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43753.1 - 0.0059 16.4 1.7 0.0059 16.4 1.7 5.0 2 1 3 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 EFC43753.1 - 2.7 8.9 17.1 30 5.7 1.3 7.0 4 2 1 5 5 5 0 Leucine Rich Repeat RGS PF00615.19 EFC43753.1 - 7.1 6.9 9.4 0.26 11.5 1.9 2.4 2 0 0 2 2 2 0 Regulator of G protein signaling domain Sec20 PF03908.13 EFC43754.1 - 8.9 6.3 8.0 3.1 7.8 0.1 3.9 5 0 0 5 5 5 0 Sec20 NAC PF01849.18 EFC43755.1 - 2.5e-12 46.6 0.3 6.8e-12 45.2 0.3 1.7 1 0 0 1 1 1 1 NAC domain VirE3 PF06661.11 EFC43755.1 - 0.023 14.0 1.8 0.035 13.4 1.8 1.3 1 0 0 1 1 1 0 VirE3 SapB_2 PF03489.17 EFC43755.1 - 0.17 12.1 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Saposin-like type B, region 2 TPR_2 PF07719.17 EFC43757.1 - 5.2e-12 44.9 6.7 0.024 14.7 0.0 7.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC43757.1 - 2e-11 43.2 9.1 0.028 14.2 0.2 7.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC43757.1 - 5.7e-09 35.5 0.9 0.00075 19.1 0.0 4.5 3 1 1 4 4 4 2 TPR repeat TPR_9 PF13371.6 EFC43757.1 - 1.3e-06 28.5 0.0 2.8e-05 24.2 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC43757.1 - 3.1e-06 27.4 5.2 0.12 12.7 0.1 5.8 4 3 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC43757.1 - 3.6e-05 23.9 5.0 0.63 10.6 0.4 5.1 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43757.1 - 3.9e-05 23.5 15.6 1.2 9.5 0.0 6.7 9 0 0 9 9 8 3 Tetratricopeptide repeat BHD_1 PF10403.9 EFC43757.1 - 0.055 13.3 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 1 TPR_10 PF13374.6 EFC43757.1 - 0.082 12.8 1.7 28 4.8 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Rsbr_N PF08678.10 EFC43757.1 - 0.2 11.7 2.0 12 5.9 0.1 3.5 3 1 0 3 3 3 0 Rsbr N terminal MIT PF04212.18 EFC43757.1 - 0.29 11.2 8.5 11 6.1 0.0 4.3 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain RCC1 PF00415.18 EFC43758.1 - 8.1e-12 45.6 0.9 0.00014 22.4 0.0 4.6 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43758.1 - 7.3e-11 41.6 0.3 7.3e-11 41.6 0.3 2.8 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Actin PF00022.19 EFC43759.1 - 1.5e-92 310.4 0.0 1.2e-89 300.8 0.0 2.0 1 1 0 1 1 1 1 Actin RGS PF00615.19 EFC43760.1 - 0.0023 18.2 4.0 0.0084 16.4 4.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF2700 PF10912.8 EFC43760.1 - 0.091 12.8 2.6 0.19 11.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2700) Marek_A PF02124.15 EFC43760.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Marek's disease glycoprotein A Baculo_11_kDa PF06143.11 EFC43760.1 - 0.45 10.1 6.3 0.25 11.0 0.4 2.6 2 0 0 2 2 2 0 Baculovirus 11 kDa family Alginate_lyase2 PF08787.11 EFC43761.1 - 2.9e-29 102.6 0.1 2.9e-29 102.6 0.1 1.8 2 1 0 2 2 2 1 Alginate lyase DUF2981 PF11200.8 EFC43761.1 - 3.1 7.5 8.0 4.7 6.9 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) LRR_8 PF13855.6 EFC43762.1 - 1.9e-22 78.8 11.5 7.2e-07 28.9 0.0 4.4 2 1 3 5 5 5 5 Leucine rich repeat LRR_6 PF13516.6 EFC43762.1 - 5e-22 76.0 16.7 0.029 14.4 0.0 9.9 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC43762.1 - 1.8e-16 60.0 18.1 6.3e-05 23.3 0.2 5.9 2 2 6 8 8 8 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC43762.1 - 4.8e-08 32.5 9.5 5.2 8.0 0.0 8.2 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC43762.1 - 1.4e-05 24.7 3.3 0.1 12.1 0.3 2.6 2 1 1 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC43762.1 - 7.8e-05 22.6 0.3 1.2 9.0 0.0 4.4 1 1 1 4 4 4 1 Domain of unknown function (DUF4347) Spore_YhaL PF14147.6 EFC43762.1 - 0.13 12.0 3.5 16 5.3 0.0 4.4 5 0 0 5 5 5 0 Sporulation protein YhaL NKWYS PF10364.9 EFC43762.1 - 0.79 9.8 6.4 2.6 8.2 0.2 2.9 1 1 2 3 3 3 0 Putative capsular polysaccharide synthesis protein SBP_bac_3 PF00497.20 EFC43763.1 - 1.5e-05 24.5 0.1 2.8e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Peptidase_S9 PF00326.21 EFC43764.1 - 1.8e-45 155.0 0.2 4.2e-45 153.8 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC43764.1 - 9e-09 35.3 0.6 6.4e-05 22.7 0.1 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 EFC43764.1 - 2.7e-07 30.5 0.0 0.0094 15.6 0.0 2.7 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 EFC43764.1 - 1.1e-06 28.1 1.3 0.00022 20.6 0.0 2.8 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 EFC43764.1 - 1.1e-05 25.0 0.8 0.00013 21.6 0.1 2.6 2 1 0 2 2 2 1 Dienelactone hydrolase family DUF2920 PF11144.8 EFC43764.1 - 3e-05 23.4 1.3 3.9e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2920) Mucin PF01456.17 EFC43764.1 - 0.0043 17.1 3.2 0.0098 15.9 3.2 1.6 1 0 0 1 1 1 1 Mucin-like glycoprotein Peptidase_S28 PF05577.12 EFC43764.1 - 0.029 13.2 0.0 0.059 12.1 0.0 1.4 1 0 0 1 1 1 0 Serine carboxypeptidase S28 Peptidase_S10 PF00450.22 EFC43764.1 - 0.34 10.3 4.7 0.51 9.7 0.1 3.1 3 1 1 4 4 4 0 Serine carboxypeptidase Trypsin_2 PF13365.6 EFC43765.1 - 3.8e-05 24.6 0.0 6.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain MIP-T3 PF10243.9 EFC43766.1 - 0.018 15.0 1.1 0.03 14.3 0.3 1.8 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 CH-like domain Sigma54_activ_2 PF14532.6 EFC43766.1 - 0.035 14.2 0.4 0.083 13.0 0.4 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain MALT1_Ig PF18703.1 EFC43766.1 - 1.4 9.0 5.9 0.25 11.4 2.5 1.5 2 0 0 2 2 2 0 MALT1 Ig-like domain DUF1525 PF07511.11 EFC43766.1 - 5.3 7.2 6.0 7.9 6.7 0.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1525) LMBR1 PF04791.16 EFC43767.1 - 1e-19 70.9 1.6 1e-19 70.9 1.6 2.3 1 1 1 2 2 2 1 LMBR1-like membrane protein ABC2_membrane PF01061.24 EFC43768.1 - 1.6e-44 151.9 27.5 1.6e-44 151.9 27.5 1.7 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 EFC43768.1 - 7.2e-27 94.6 0.8 1.2e-26 93.8 0.0 1.8 2 0 0 2 2 1 1 ABC transporter AAA_16 PF13191.6 EFC43768.1 - 2.5e-05 24.7 0.0 6.8e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 EFC43768.1 - 0.00013 21.9 0.6 0.29 10.9 0.0 2.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC43768.1 - 0.00063 19.2 0.1 0.00063 19.2 0.1 3.1 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFC43768.1 - 0.00072 19.8 0.3 0.0085 16.4 0.1 2.5 2 1 0 2 2 1 1 AAA domain RsgA_GTPase PF03193.16 EFC43768.1 - 0.00075 19.4 0.1 0.0016 18.4 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA PF00004.29 EFC43768.1 - 0.0048 17.3 0.3 0.049 14.1 0.3 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFC43768.1 - 0.0083 16.1 0.0 0.02 14.8 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_33 PF13671.6 EFC43768.1 - 0.026 14.7 0.0 0.085 13.0 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFC43768.1 - 0.042 13.9 0.0 0.64 10.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.14 EFC43768.1 - 0.043 13.1 0.3 0.081 12.1 0.0 1.7 2 0 0 2 2 2 0 KAP family P-loop domain AAA_35 PF14516.6 EFC43768.1 - 0.046 12.5 0.0 0.093 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain AAA_5 PF07728.14 EFC43768.1 - 0.051 13.6 0.1 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EFC43768.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC43768.1 - 0.11 13.0 1.1 0.36 11.4 0.0 2.3 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 EFC43768.1 - 0.12 12.2 0.4 10 6.0 0.0 2.3 2 0 0 2 2 2 0 NTPase PRK PF00485.18 EFC43768.1 - 0.14 11.8 0.1 0.48 10.1 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 EFC43768.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 EFC43768.1 - 0.17 11.6 0.1 0.29 10.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFC43768.1 - 0.17 11.4 0.0 0.41 10.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain U-box PF04564.15 EFC43769.1 - 0.0007 19.7 0.0 0.0027 17.8 0.0 2.0 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 EFC43769.1 - 0.014 15.5 0.0 0.053 13.7 0.0 2.0 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein PP2C_C PF07830.13 EFC43769.1 - 0.014 15.8 0.2 0.11 13.0 0.0 2.6 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain TerB_C PF15615.6 EFC43769.1 - 0.24 11.7 11.1 0.025 14.9 2.1 2.7 2 0 0 2 2 2 0 TerB-C domain EF-hand_1 PF00036.32 EFC43770.1 - 5.1e-19 66.3 2.9 3.8e-06 26.0 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFC43770.1 - 2.2e-17 63.2 5.1 5.6e-10 39.5 1.4 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC43770.1 - 1.1e-14 53.0 7.2 0.00029 20.5 0.0 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EFC43770.1 - 5.6e-09 35.1 8.5 6.8e-05 22.2 0.2 4.3 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EFC43770.1 - 3.8e-07 29.8 2.4 0.079 12.8 0.0 3.5 3 1 0 3 3 3 2 EF-hand domain pair Glyco_hydro_76 PF03663.14 EFC43772.1 - 2.2e-32 113.0 7.0 2.9e-32 112.6 7.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 EFC43772.1 - 4.2e-05 22.8 1.8 0.025 13.7 0.0 2.5 1 1 1 2 2 2 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 EFC43772.1 - 0.0026 17.3 0.2 0.6 9.6 0.0 2.7 3 0 0 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 EFC43772.1 - 0.0038 15.8 0.2 0.048 12.2 0.1 2.0 1 1 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 PDDEXK_9 PF08011.11 EFC43773.1 - 0.0038 17.1 0.1 0.012 15.5 0.1 1.8 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily YbaB_DNA_bd PF02575.16 EFC43774.1 - 1.7e-13 50.6 0.1 2e-13 50.4 0.1 1.1 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family Diphtheria_C PF02763.14 EFC43774.1 - 0.14 11.8 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Diphtheria toxin, C domain NYN_YacP PF05991.11 EFC43775.1 - 1.3e-06 28.4 5.1 1.5e-06 28.3 0.0 2.5 3 0 0 3 3 3 1 YacP-like NYN domain SPT6_acidic PF14632.6 EFC43775.1 - 0.0031 18.1 5.3 0.0031 18.1 5.3 2.2 2 0 0 2 2 2 1 Acidic N-terminal SPT6 PIN_9 PF18477.1 EFC43775.1 - 0.0035 17.6 1.1 0.038 14.3 0.0 2.8 3 0 0 3 3 3 1 PIN like domain Helicase_RecD PF05127.14 EFC43775.1 - 0.069 13.0 1.1 0.11 12.3 0.3 1.8 1 1 1 2 2 2 0 Helicase Toprim_Crpt PF13342.6 EFC43775.1 - 0.13 12.2 1.6 0.54 10.3 0.3 2.4 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase LRR_6 PF13516.6 EFC43776.1 - 2.8e-25 86.2 11.9 3.2e-06 26.8 0.1 7.3 7 0 0 7 7 7 5 Leucine Rich repeat LRR_1 PF00560.33 EFC43776.1 - 4.3e-05 23.5 0.6 6.3 7.8 0.0 4.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_4 PF12799.7 EFC43776.1 - 8.5e-05 22.8 11.7 0.41 11.1 0.2 4.8 3 3 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43776.1 - 0.0016 18.2 4.6 0.93 9.3 0.3 4.5 2 2 1 3 3 3 2 Leucine rich repeat SpoU_sub_bind PF08032.12 EFC43776.1 - 0.066 13.5 1.6 21 5.4 0.0 3.9 4 1 2 6 6 6 0 RNA 2'-O ribose methyltransferase substrate binding DUF4252 PF14060.6 EFC43776.1 - 0.48 10.3 6.7 1.7 8.5 0.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4252) zf-CDGSH PF09360.10 EFC43778.1 - 2.4e-20 72.5 7.0 1.1e-09 38.3 0.4 2.5 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type DUF4503 PF14951.6 EFC43778.1 - 0.053 12.0 0.0 0.057 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) FMN_bind_2 PF04299.12 EFC43779.1 - 9.1e-42 142.6 0.1 1.8e-41 141.7 0.1 1.5 1 0 0 1 1 1 1 Putative FMN-binding domain MtaB PF12176.8 EFC43779.1 - 0.05 12.4 0.3 0.14 10.9 0.3 1.7 1 0 0 1 1 1 0 Methanol-cobalamin methyltransferase B subunit NHL PF01436.21 EFC43780.1 - 0.037 14.1 1.9 14 6.0 0.0 3.6 3 0 0 3 3 3 0 NHL repeat SGL PF08450.12 EFC43780.1 - 0.051 13.2 0.1 3.6 7.1 0.0 2.6 2 2 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC43780.1 - 0.053 13.7 0.8 0.5 10.6 0.1 2.7 2 1 1 3 3 3 0 Arylesterase Luciferase_cat PF10285.9 EFC43780.1 - 0.066 12.6 0.0 0.34 10.3 0.0 1.8 2 0 0 2 2 2 0 Luciferase catalytic domain Hemerythrin PF01814.23 EFC43781.1 - 9.5e-10 39.2 1.1 9.5e-10 39.2 1.1 1.9 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain Phage_Integr_2 PF13009.6 EFC43781.1 - 0.024 13.8 1.1 0.028 13.5 1.1 1.1 1 0 0 1 1 1 0 Putative phage integrase DUF1948 PF09185.10 EFC43781.1 - 0.045 13.6 0.1 0.068 13.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) WD40 PF00400.32 EFC43782.1 - 7.7e-32 108.8 22.2 1.3e-08 35.3 0.3 6.8 7 1 0 7 7 7 5 WD domain, G-beta repeat FapA PF03961.13 EFC43782.1 - 0.0031 16.2 4.3 0.0056 15.4 4.3 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A TMF_TATA_bd PF12325.8 EFC43782.1 - 0.046 13.9 8.0 0.13 12.4 8.0 1.8 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding HAUS6_N PF14661.6 EFC43782.1 - 0.13 11.8 4.9 0.33 10.5 4.9 1.6 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DHR10 PF18595.1 EFC43782.1 - 0.44 10.6 10.2 0.88 9.6 10.2 1.5 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain DUF4407 PF14362.6 EFC43782.1 - 0.77 9.1 6.1 1.4 8.2 6.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 EFC43782.1 - 1 9.4 4.9 2.4 8.2 4.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) BRE1 PF08647.11 EFC43782.1 - 3.4 7.8 14.7 8.3 6.6 14.7 1.6 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Ta0938 PF11494.8 EFC43784.1 - 0.13 12.6 3.2 12 6.2 0.4 2.9 2 1 1 3 3 3 0 Ta0938 WBP-1 PF11669.8 EFC43785.1 - 0.17 12.5 0.3 1.4 9.6 0.0 2.6 3 0 0 3 3 3 0 WW domain-binding protein 1 EphA2_TM PF14575.6 EFC43785.1 - 0.25 12.2 5.8 4.4 8.3 0.0 3.9 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 EFC43785.1 - 1.6 9.0 5.8 13 6.1 0.1 3.5 3 0 0 3 3 3 0 Chordopoxvirus A13L protein RNA_ligase PF09414.10 EFC43786.1 - 1.1e-25 90.8 0.0 1.8e-25 90.1 0.0 1.3 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 EFC43786.1 - 7e-21 74.2 0.6 2.1e-20 72.6 0.1 2.1 2 0 0 2 2 2 1 T4 RNA ligase 2 C-terminal IAT_beta PF11924.8 EFC43786.1 - 0.0039 16.7 0.0 0.0074 15.7 0.0 1.4 1 0 0 1 1 1 1 Inverse autotransporter, beta-domain Prominin PF05478.11 EFC43787.1 - 5.7e-05 21.3 30.5 0.00033 18.8 10.0 3.5 2 2 1 3 3 3 2 Prominin Ni_hydr_CYTB PF01292.20 EFC43787.1 - 0.11 12.1 1.8 0.34 10.5 0.4 2.3 2 1 0 2 2 2 0 Prokaryotic cytochrome b561 Endotoxin_C2 PF18449.1 EFC43787.1 - 0.24 11.8 4.0 0.63 10.4 0.5 3.2 3 0 0 3 3 3 0 Delta endotoxin NdhM PF10664.9 EFC43789.1 - 0.037 14.3 0.4 0.13 12.6 0.1 2.1 2 0 0 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M LRR_9 PF14580.6 EFC43790.1 - 5e-09 35.9 0.1 1.6e-08 34.2 0.1 1.9 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC43790.1 - 0.0038 17.6 2.9 0.75 10.3 0.0 2.8 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43790.1 - 0.037 13.8 0.7 0.12 12.2 0.0 2.2 2 0 0 2 2 2 0 Leucine rich repeat EGF_2 PF07974.13 EFC43791.1 - 8.8e-52 173.1 537.9 0.00021 21.6 6.9 34.3 34 0 0 34 34 34 31 EGF-like domain Mor PF08765.11 EFC43791.1 - 0.0013 18.7 0.0 54 3.8 0.0 5.5 7 1 0 7 7 7 1 Mor transcription activator family SKG6 PF08693.10 EFC43791.1 - 1.8 8.1 8.8 4.5 6.8 8.8 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain NAD_binding_8 PF13450.6 EFC43792.1 - 0.0003 20.9 0.0 0.00059 20.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain La PF05383.17 EFC43793.1 - 3.9e-17 62.0 0.1 6.4e-17 61.4 0.1 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 EFC43793.1 - 1.3e-06 28.1 0.2 3.4e-06 26.8 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 EFC43793.1 - 0.029 14.4 0.2 0.13 12.3 0.2 2.1 1 1 0 1 1 1 0 RNA binding motif PTS_2-RNA PF01885.16 EFC43793.1 - 0.064 13.3 0.0 0.07 13.2 0.0 1.2 1 0 0 1 1 1 0 RNA 2'-phosphotransferase, Tpt1 / KptA family Zip PF02535.22 EFC43794.1 - 1.4e-19 70.5 11.3 1.9e-15 56.9 2.2 2.6 1 1 1 2 2 2 2 ZIP Zinc transporter Peptidase_C2 PF00648.21 EFC43795.1 - 1.6e-35 122.6 0.0 4e-35 121.3 0.0 1.7 2 0 0 2 2 2 1 Calpain family cysteine protease EGF_2 PF07974.13 EFC43796.1 - 4.7e-52 174.0 396.0 2.4e-05 24.6 5.6 24.3 24 0 0 24 24 24 23 EGF-like domain Beta_helix PF13229.6 EFC43797.1 - 2.5e-22 79.4 42.3 2.8e-20 72.7 28.8 2.9 2 1 1 3 3 3 2 Right handed beta helix region Nore1-SARAH PF16517.5 EFC43798.1 - 0.014 15.3 0.2 0.014 15.3 0.2 2.2 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain AAA_24 PF13479.6 EFC43798.1 - 0.12 12.1 0.5 0.4 10.4 0.1 1.9 2 0 0 2 2 2 0 AAA domain RnlB_antitoxin PF15933.5 EFC43798.1 - 0.41 11.0 8.2 0.048 14.0 1.5 2.6 2 1 0 2 2 2 0 Antitoxin to bacterial toxin RNase LS or RnlA EGF_2 PF07974.13 EFC43799.1 - 3.7e-54 180.7 433.6 0.0001 22.6 5.3 27.5 26 1 1 27 27 27 24 EGF-like domain SKG6 PF08693.10 EFC43799.1 - 6.2 6.3 11.3 15 5.1 11.3 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LRR_9 PF14580.6 EFC43800.1 - 1.4e-08 34.4 0.1 1.4e-08 34.4 0.1 1.8 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EFC43800.1 - 1.5e-08 34.8 0.4 5.8e-05 23.4 0.0 3.1 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC43800.1 - 6.7e-06 25.8 0.3 0.00018 21.2 0.6 2.7 2 1 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 EFC43800.1 - 0.12 13.0 1.5 48 5.1 0.0 3.9 3 0 0 3 3 3 0 Leucine Rich Repeat Csm1_N PF18504.1 EFC43800.1 - 2 8.8 13.5 1.4 9.3 2.8 3.7 3 0 0 3 3 3 0 Csm1 N-terminal domain DUF4116 PF13475.6 EFC43801.1 - 2.4e-38 129.6 15.0 2.8e-08 33.4 0.3 6.3 2 2 3 6 6 6 6 Domain of unknown function (DUF4116) Clenterotox PF03505.14 EFC43801.1 - 0.024 14.2 0.2 0.15 11.6 0.0 2.1 2 0 0 2 2 2 0 Clostridium enterotoxin UDPG_MGDP_dh_N PF03721.14 EFC43802.1 - 1.4e-59 200.8 0.0 2.9e-59 199.8 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 EFC43802.1 - 1.5e-35 121.8 0.2 5.2e-35 120.0 0.0 2.0 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 EFC43802.1 - 2.4e-30 104.6 0.0 4.9e-30 103.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.18 EFC43802.1 - 0.00022 21.1 0.0 0.00056 19.8 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFC43802.1 - 0.0019 18.4 0.0 0.031 14.5 0.0 2.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EFC43802.1 - 0.0098 16.2 0.0 0.079 13.2 0.0 2.2 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.23 EFC43802.1 - 0.013 15.6 0.0 0.14 12.2 0.0 2.5 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 EFC43802.1 - 0.044 13.8 0.0 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DEAD PF00270.29 EFC43803.1 - 0.059 13.1 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF3584 PF12128.8 EFC43804.1 - 0.0024 15.5 7.3 0.0029 15.2 7.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) F-box-like PF12937.7 EFC43804.1 - 0.0063 16.4 0.1 0.01 15.7 0.1 1.3 1 0 0 1 1 1 1 F-box-like SKA2 PF16740.5 EFC43804.1 - 0.0073 16.1 5.1 0.0073 16.1 5.1 2.1 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 2 FAM184 PF15665.5 EFC43804.1 - 0.11 12.3 12.8 0.092 12.5 3.2 2.0 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B F-box PF00646.33 EFC43804.1 - 0.21 11.5 0.4 0.21 11.5 0.4 1.7 2 0 0 2 2 2 0 F-box domain PRANC PF09372.10 EFC43804.1 - 0.36 11.2 0.1 0.36 11.2 0.1 3.1 1 1 2 3 3 3 0 PRANC domain DUF1664 PF07889.12 EFC43804.1 - 0.49 10.4 9.3 0.61 10.1 3.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 EFC43804.1 - 1 10.0 18.3 0.26 11.9 10.9 2.4 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Exonuc_VII_L PF02601.15 EFC43804.1 - 2.8 7.4 7.2 3.5 7.1 7.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Seryl_tRNA_N PF02403.22 EFC43804.1 - 5.1 7.4 16.2 2.1 8.6 2.9 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FtsH_ext PF06480.15 EFC43805.1 - 0.077 13.4 0.0 0.3 11.5 0.0 2.2 1 0 0 1 1 1 0 FtsH Extracellular FIBP PF05427.11 EFC43806.1 - 3.1e-54 184.7 16.9 1.7e-52 178.9 16.9 3.1 1 1 0 1 1 1 1 Acidic fibroblast growth factor binding (FIBP) RasGAP PF00616.19 EFC43806.1 - 3.8e-29 101.9 8.5 3.8e-29 101.9 8.5 3.6 4 1 0 4 4 4 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 EFC43806.1 - 3.1e-07 30.8 0.4 0.00044 20.7 0.0 3.0 2 0 0 2 2 2 2 PH domain Colicin_Pyocin PF01320.18 EFC43806.1 - 0.45 10.7 2.7 29 4.9 0.7 3.7 2 0 0 2 2 2 0 Colicin immunity protein / pyocin immunity protein EGF_2 PF07974.13 EFC43807.1 - 4.6e-67 222.0 467.3 9.5e-06 25.9 6.8 29.4 29 0 0 29 29 29 27 EGF-like domain NHL PF01436.21 EFC43807.1 - 0.0024 17.8 0.2 1.7 8.9 0.0 4.4 2 0 0 2 2 2 1 NHL repeat SKG6 PF08693.10 EFC43807.1 - 2.4 7.6 12.3 6.2 6.3 12.3 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Beta_helix PF13229.6 EFC43808.1 - 2.7e-21 76.1 43.0 3.5e-16 59.5 27.1 3.0 2 1 1 3 3 3 2 Right handed beta helix region DUF3915 PF13054.6 EFC43808.1 - 0.04 13.9 1.1 0.18 11.8 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3915) PhoPQ_related PF10142.9 EFC43809.1 - 1.1e-99 333.6 0.9 1.2e-99 333.4 0.9 1.0 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein CdAMP_rec PF06153.11 EFC43809.1 - 0.045 14.0 0.0 0.098 12.9 0.0 1.6 1 0 0 1 1 1 0 Cyclic-di-AMP receptor WAC_Acf1_DNA_bd PF10537.9 EFC43811.1 - 9.3e-26 90.3 3.1 9.3e-26 90.3 3.1 1.5 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal RNA_pol_Rpb6 PF01192.22 EFC43812.1 - 1.4e-14 53.7 0.1 2.4e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 Nucleic_acid_bd PF13820.6 EFC43812.1 - 0.064 13.1 0.1 0.095 12.5 0.1 1.3 1 0 0 1 1 1 0 Putative nucleic acid-binding region Couple_hipA PF13657.6 EFC43812.1 - 0.13 12.9 0.0 0.18 12.5 0.0 1.3 1 0 0 1 1 1 0 HipA N-terminal domain eIF-5_eIF-2B PF01873.17 EFC43813.1 - 3.3e-31 107.6 0.2 5.4e-31 106.9 0.2 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 EFC43813.1 - 3.3e-06 27.1 5.6 6.3e-06 26.2 0.1 2.5 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Synaptobrevin PF00957.21 EFC43814.1 - 3.4e-23 81.2 0.6 7.4e-23 80.2 0.6 1.6 1 0 0 1 1 1 1 Synaptobrevin AAA_22 PF13401.6 EFC43814.1 - 0.007 16.6 1.4 0.02 15.2 1.4 1.9 1 1 0 1 1 1 1 AAA domain PMC2NT PF08066.12 EFC43814.1 - 0.047 14.4 1.1 4.6 8.0 0.0 2.4 2 0 0 2 2 2 0 PMC2NT (NUC016) domain Retrotrans_gag PF03732.17 EFC43814.1 - 0.097 13.0 1.8 0.62 10.4 0.2 2.2 2 0 0 2 2 2 0 Retrotransposon gag protein Fz PF01392.22 EFC43815.1 - 1.4e-06 28.9 2.0 1.7e-06 28.6 2.0 1.1 1 0 0 1 1 1 1 Fz domain Ras PF00071.22 EFC43816.1 - 0.00014 21.5 0.5 0.0003 20.4 0.0 1.7 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFC43816.1 - 0.00047 20.4 0.1 0.0028 17.9 0.0 2.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43816.1 - 0.00057 19.4 0.1 0.00076 19.0 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EFC43816.1 - 0.02 14.4 0.1 0.031 13.8 0.1 1.4 1 1 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 EFC43816.1 - 0.025 13.8 2.2 0.041 13.1 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit DAP3 PF10236.9 EFC43816.1 - 0.027 13.7 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 TsaE PF02367.17 EFC43816.1 - 0.066 13.2 0.1 0.087 12.8 0.1 1.3 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PTPlike_phytase PF14566.6 EFC43816.1 - 0.19 11.8 2.5 0.25 11.4 2.5 1.2 1 1 0 1 1 1 0 Inositol hexakisphosphate Myosin_head PF00063.21 EFC43817.1 - 3e-188 627.2 18.2 3.7e-188 626.9 18.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Zeta_toxin PF06414.12 EFC43817.1 - 0.0047 16.2 0.5 0.017 14.4 0.0 2.1 3 0 0 3 3 3 1 Zeta toxin AAA_22 PF13401.6 EFC43817.1 - 0.016 15.5 0.1 0.25 11.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC43817.1 - 0.078 13.3 0.0 0.25 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain zf-RING_2 PF13639.6 EFC43818.1 - 1.8e-12 47.4 6.2 1.8e-12 47.4 6.2 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC43818.1 - 2.5e-09 36.8 5.7 6.5e-09 35.5 5.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC43818.1 - 1.4e-08 34.4 1.9 1.4e-08 34.4 1.9 2.8 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 EFC43818.1 - 1.2e-06 28.3 6.1 1.2e-06 28.3 6.1 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_9 PF14369.6 EFC43818.1 - 2e-06 27.9 0.5 2e-06 27.9 0.5 2.8 3 0 0 3 3 3 1 zinc-ribbon zf-C3HC4_3 PF13920.6 EFC43818.1 - 2.2e-06 27.4 6.4 2.2e-06 27.4 6.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFC43818.1 - 2.9e-06 27.5 8.8 2.9e-06 27.5 8.8 2.3 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFC43818.1 - 3.9e-06 26.8 1.9 5.2e-06 26.4 0.8 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFC43818.1 - 9.3e-06 25.5 4.0 9.3e-06 25.5 4.0 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFC43818.1 - 6.7e-05 22.7 3.1 6.7e-05 22.7 3.1 2.5 2 1 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 EFC43818.1 - 0.013 15.6 4.2 0.027 14.5 4.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger A2L_zn_ribbon PF08792.10 EFC43818.1 - 0.024 14.3 1.5 0.024 14.3 1.5 2.2 2 0 0 2 2 1 0 A2L zinc ribbon domain Zn_ribbon_17 PF17120.5 EFC43818.1 - 9 6.0 16.1 0.17 11.5 8.9 1.9 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type Peptidase_S10 PF00450.22 EFC43820.1 - 6.9e-92 309.0 7.1 7.7e-92 308.9 7.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DNA_pol_A_exo1 PF01612.20 EFC43821.1 - 0.0001 22.1 0.2 0.00061 19.5 0.1 2.3 1 1 0 2 2 2 1 3'-5' exonuclease Pkinase PF00069.25 EFC43822.1 - 2.1e-74 250.2 0.0 2.6e-74 249.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43822.1 - 2e-47 161.7 0.0 2.6e-47 161.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43822.1 - 1.3e-06 28.0 0.0 3.7e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 EFC43822.1 - 4.5e-05 23.5 0.2 0.066 13.1 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC43822.1 - 0.00079 18.5 0.2 0.0012 17.8 0.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 EFC43822.1 - 0.004 16.7 0.2 0.0073 15.8 0.2 1.4 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 EFC43822.1 - 0.016 14.3 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 EFC43822.1 - 0.03 13.1 0.1 0.045 12.5 0.1 1.4 1 1 0 1 1 1 0 Fungal protein kinase MIF4G_like_2 PF09090.11 EFC43823.1 - 1.9e-38 132.5 0.9 1.8e-37 129.3 0.2 2.3 2 0 0 2 2 2 1 MIF4G like MIF4G_like PF09088.11 EFC43823.1 - 2.9e-12 46.8 0.5 7.4e-12 45.4 0.2 1.8 2 0 0 2 2 2 1 MIF4G like MIF4G PF02854.19 EFC43823.1 - 5.4e-10 39.3 1.3 5.4e-10 39.3 1.3 2.7 3 0 0 3 3 3 1 MIF4G domain DUF1617 PF07761.12 EFC43823.1 - 0.063 13.4 1.9 0.28 11.3 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1617) TraU PF06834.11 EFC43823.1 - 0.18 11.0 0.6 0.3 10.3 0.6 1.3 1 0 0 1 1 1 0 TraU protein HAUS5 PF14817.6 EFC43824.1 - 2e-19 69.9 24.0 8.5e-12 44.6 5.6 2.1 1 1 0 2 2 2 2 HAUS augmin-like complex subunit 5 YtxH PF12732.7 EFC43824.1 - 0.74 10.4 4.6 64 4.2 4.5 3.6 1 1 0 1 1 1 0 YtxH-like protein DUF3209 PF11483.8 EFC43824.1 - 1.4 9.4 5.2 5.4 7.5 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3209) Vac14_Fab1_bd PF12755.7 EFC43825.1 - 0.0065 17.0 0.1 0.045 14.3 0.1 2.5 1 0 0 1 1 1 1 Vacuolar 14 Fab1-binding region AAA PF00004.29 EFC43826.1 - 1.5e-39 135.4 0.0 3.3e-39 134.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC43826.1 - 4.3e-10 39.2 0.1 1.5e-09 37.5 0.1 1.9 2 0 0 2 2 1 1 AAA+ lid domain RuvB_N PF05496.12 EFC43826.1 - 7.9e-05 22.5 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC43826.1 - 0.00018 21.8 1.5 0.013 15.8 1.5 2.7 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 EFC43826.1 - 0.0012 18.1 0.0 0.003 16.8 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 EFC43826.1 - 0.0018 18.3 0.1 0.0052 16.8 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFC43826.1 - 0.0022 17.4 0.1 0.0069 15.8 0.0 1.8 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFC43826.1 - 0.0029 17.4 0.0 0.0072 16.1 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EFC43826.1 - 0.0032 17.9 0.4 0.035 14.5 0.3 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFC43826.1 - 0.0047 16.7 2.4 0.013 15.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 EFC43826.1 - 0.0059 16.7 0.2 0.05 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) ABC_tran PF00005.27 EFC43826.1 - 0.0083 16.6 0.6 0.081 13.4 0.0 2.6 3 0 0 3 3 2 1 ABC transporter AAA_33 PF13671.6 EFC43826.1 - 0.011 15.9 0.1 0.048 13.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFC43826.1 - 0.011 15.8 0.0 0.052 13.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC43826.1 - 0.015 15.9 2.6 0.039 14.5 0.0 2.8 4 0 0 4 4 3 0 AAA domain AAA_7 PF12775.7 EFC43826.1 - 0.015 14.8 0.0 0.035 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Vps4_C PF09336.10 EFC43826.1 - 0.016 15.2 0.0 0.05 13.6 0.0 1.9 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain FIBP PF05427.11 EFC43826.1 - 0.019 14.3 0.2 0.14 11.4 0.0 2.2 1 1 1 2 2 2 0 Acidic fibroblast growth factor binding (FIBP) DUF815 PF05673.13 EFC43826.1 - 0.02 14.1 0.0 0.038 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 EFC43826.1 - 0.027 14.1 0.4 0.098 12.2 0.4 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFC43826.1 - 0.029 14.7 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EFC43826.1 - 0.062 13.2 0.1 0.26 11.2 0.1 2.1 1 1 0 1 1 1 0 NACHT domain PhoH PF02562.16 EFC43826.1 - 0.068 12.6 0.0 0.16 11.4 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EFC43826.1 - 0.092 13.0 0.2 0.36 11.0 0.1 2.1 2 1 0 2 2 2 0 AAA domain SRP-alpha_N PF04086.13 EFC43826.1 - 0.11 12.4 14.4 0.21 11.5 14.4 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ndc1_Nup PF09531.10 EFC43826.1 - 0.12 11.1 5.7 0.17 10.6 5.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NAM-associated PF14303.6 EFC43826.1 - 0.68 10.6 18.2 0.13 13.0 14.1 1.9 2 0 0 2 2 1 0 No apical meristem-associated C-terminal domain PPP4R2 PF09184.11 EFC43826.1 - 3 7.4 21.4 6.8 6.2 21.4 1.5 1 0 0 1 1 1 0 PPP4R2 COMM_domain PF07258.14 EFC43827.1 - 1.1e-12 47.8 0.1 1.1e-12 47.8 0.1 2.3 3 0 0 3 3 3 1 COMM domain HU-CCDC81_euk_2 PF18289.1 EFC43827.1 - 0.063 13.4 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 2 Pkinase PF00069.25 EFC43828.1 - 1e-47 162.7 0.0 1.5e-47 162.2 0.0 1.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43828.1 - 3.2e-21 75.8 0.0 5.1e-21 75.1 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43828.1 - 6.4e-05 22.4 0.0 0.018 14.3 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Choline_kinase PF01633.20 EFC43828.1 - 0.00025 20.7 0.1 0.00038 20.1 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 EFC43828.1 - 0.0014 17.6 0.2 0.0019 17.2 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC43828.1 - 0.014 15.3 0.1 0.12 12.3 0.3 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1081 PF06448.11 EFC43829.1 - 0.48 10.8 7.4 0.2 12.0 3.2 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1081) DUF3395 PF11875.8 EFC43830.1 - 1.9e-16 60.3 1.4 1.2e-15 57.8 0.8 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3395) FH2 PF02181.23 EFC43832.1 - 8.6e-79 265.3 8.5 8.6e-79 265.3 8.5 3.3 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFC43832.1 - 1e-19 70.9 7.9 1e-19 70.9 7.9 2.6 2 1 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EFC43832.1 - 2.2e-08 33.9 9.4 3.2e-08 33.4 0.1 3.6 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain SOG2 PF10428.9 EFC43832.1 - 1.3 8.1 34.7 0.071 12.3 27.2 2.4 2 0 0 2 2 2 0 RAM signalling pathway protein DUF4407 PF14362.6 EFC43832.1 - 2.3 7.5 13.5 0.5 9.7 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) zf-C3HC4_3 PF13920.6 EFC43833.1 - 0.0061 16.4 22.0 0.0061 16.4 22.0 3.8 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) Folate_carrier PF01770.18 EFC43833.1 - 2.4 6.8 7.9 0.44 9.2 0.1 2.2 2 0 0 2 2 2 0 Reduced folate carrier Sel1 PF08238.12 EFC43834.1 - 1.7e-15 57.1 1.9 0.012 16.3 0.0 5.8 6 0 0 6 6 6 4 Sel1 repeat TPR_2 PF07719.17 EFC43835.1 - 1.2e-05 25.0 1.5 0.01 15.9 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC43835.1 - 0.0041 17.0 0.3 0.5 10.5 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43835.1 - 0.0048 17.0 6.3 0.069 13.4 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC43835.1 - 0.011 15.5 3.9 0.018 14.9 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 EFC43835.1 - 3.7 7.7 8.6 18 5.5 0.2 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain RGS PF00615.19 EFC43836.1 - 0.00028 21.2 1.4 0.00028 21.2 1.4 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain RNA_pol_Rpb2_2 PF04561.14 EFC43836.1 - 0.04 13.5 0.3 0.066 12.8 0.3 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 2 MMM1 PF10296.9 EFC43837.1 - 9.7e-15 54.4 5.4 3.9e-10 39.3 0.6 2.5 1 1 2 3 3 3 2 Maintenance of mitochondrial morphology protein 1 Orai-1 PF07856.12 EFC43837.1 - 0.038 13.7 0.8 0.062 13.0 0.8 1.2 1 0 0 1 1 1 0 Mediator of CRAC channel activity Ribosomal_S19 PF00203.21 EFC43838.1 - 2e-29 101.3 0.1 2.4e-29 101.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Adaptin_N PF01602.20 EFC43839.1 - 1.2e-87 294.6 13.4 1.6e-87 294.3 13.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EFC43839.1 - 1.8e-05 25.0 0.3 0.5 10.8 0.0 4.2 4 0 0 4 4 4 1 HEAT repeats Cnd1 PF12717.7 EFC43839.1 - 2.4e-05 24.4 4.5 0.00053 20.1 0.0 3.1 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.7 EFC43839.1 - 0.00028 20.2 2.5 0.0023 17.2 0.8 2.6 1 1 1 2 2 2 1 Nuclear condensing complex subunits, C-term domain tRNA-Thr_ED PF08915.11 EFC43839.1 - 0.024 14.7 0.0 1.5 8.9 0.0 3.1 4 0 0 4 4 4 0 Archaea-specific editing domain of threonyl-tRNA synthetase HEAT PF02985.22 EFC43839.1 - 0.027 14.7 0.1 4.6 7.8 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat Vac14_Fab1_bd PF12755.7 EFC43839.1 - 0.11 13.1 0.5 7.5 7.2 0.1 3.7 3 2 1 4 4 4 0 Vacuolar 14 Fab1-binding region Pro_isomerase PF00160.21 EFC43840.1 - 2.1e-37 128.8 0.1 3.2e-37 128.3 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF5001 PF16392.5 EFC43842.1 - 0.0036 17.2 0.0 0.012 15.5 0.0 1.8 1 0 0 1 1 1 1 Ig-like domain ANAPC4_WD40 PF12894.7 EFC43842.1 - 0.0046 17.2 0.0 1.1 9.6 0.0 3.4 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain NHL PF01436.21 EFC43842.1 - 1.3 9.2 7.5 1.6e+02 2.6 0.0 5.4 6 1 1 7 7 7 0 NHL repeat FtsX PF02687.21 EFC43843.1 - 2.5e-17 63.1 23.3 5.6e-10 39.6 5.8 6.3 7 0 0 7 7 7 4 FtsX-like permease family adh_short PF00106.25 EFC43844.1 - 1.6e-18 66.9 0.0 1.9e-10 40.6 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43844.1 - 6.2e-07 29.2 0.0 3.1e-05 23.7 0.0 2.3 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43844.1 - 0.0043 17.0 0.0 0.008 16.1 0.0 1.4 1 0 0 1 1 1 1 KR domain ScsC_N PF18312.1 EFC43844.1 - 0.071 12.9 0.0 0.071 12.9 0.0 1.9 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain tRNA-synt_1c PF00749.21 EFC43845.1 - 6.5e-103 343.9 0.1 9.2e-103 343.4 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 EFC43845.1 - 1.1e-37 129.6 0.8 1.1e-37 129.6 0.8 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 EFC43845.1 - 1.9e-05 24.2 0.1 4.1e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain NHL PF01436.21 EFC43846.1 - 3.3e-21 74.2 7.5 7.9e-06 25.6 0.1 8.2 8 0 0 8 8 8 6 NHL repeat SGL PF08450.12 EFC43846.1 - 0.0031 17.1 0.1 0.23 11.0 0.0 3.8 3 3 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region REJ PF02010.15 EFC43847.1 - 3.2e-15 55.9 6.3 3.2e-15 55.9 6.3 3.5 3 0 0 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC43847.1 - 1.1e-13 51.3 74.1 0.0029 17.9 7.3 6.2 5 0 0 5 5 5 5 EGF-like domain Peptidase_S24 PF00717.23 EFC43847.1 - 0.0071 16.3 0.5 0.52 10.3 0.1 3.2 2 0 0 2 2 2 1 Peptidase S24-like ubiquitin PF00240.23 EFC43848.1 - 8.9e-135 438.7 21.3 3.6e-33 113.2 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EFC43848.1 - 1.4e-65 217.0 21.5 7.2e-16 57.8 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC43848.1 - 2.8e-23 82.2 11.2 0.0003 21.2 0.2 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC43848.1 - 8.9e-17 60.8 5.0 0.016 15.1 0.1 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC43848.1 - 4.9e-16 58.9 9.2 0.014 15.8 0.1 4.1 1 1 3 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC43848.1 - 4.3e-15 55.8 3.8 0.07 13.2 0.0 5.1 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC43848.1 - 1.8e-13 51.0 1.4 0.27 11.8 0.0 4.2 1 1 2 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC43848.1 - 1.2e-11 44.7 0.4 0.43 10.4 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EFC43848.1 - 6.1e-09 35.8 25.1 5 7.2 0.2 8.0 8 0 0 8 8 8 4 Ubiquitin-like domain DUF3861 PF12977.7 EFC43848.1 - 1.8e-06 28.0 2.9 9.8 6.4 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) Methyltrans_RNA PF04452.14 EFC43848.1 - 1.9e-06 27.4 1.3 1.3 8.3 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase DUF2870 PF11069.8 EFC43848.1 - 4e-06 27.1 0.0 30 5.1 0.0 5.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) UDP-g_GGTase PF06427.11 EFC43848.1 - 1e-05 25.6 7.0 2.1 8.5 0.1 4.2 4 0 0 4 4 4 3 UDP-glucose:Glycoprotein Glucosyltransferase ACT_5 PF13710.6 EFC43848.1 - 4.8e-05 23.1 6.0 11 5.9 0.1 4.3 4 0 0 4 4 4 0 ACT domain RBD PF02196.15 EFC43848.1 - 5.6e-05 23.1 0.0 40 4.4 0.0 4.3 4 0 0 4 4 4 0 Raf-like Ras-binding domain YcgR_2 PF12945.7 EFC43848.1 - 0.00033 20.7 6.2 22 5.3 0.1 4.3 4 0 0 4 4 4 0 Flagellar protein YcgR DUF969 PF06149.12 EFC43848.1 - 0.0004 19.9 0.0 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) DUF1866 PF08952.11 EFC43848.1 - 0.00044 20.1 1.7 38 4.1 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1866) UN_NPL4 PF11543.8 EFC43848.1 - 0.00068 20.1 3.7 45 4.6 0.0 4.3 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 ProRS-C_2 PF09181.10 EFC43848.1 - 0.0013 18.8 10.5 16 5.7 0.1 4.2 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Big_7 PF17957.1 EFC43848.1 - 0.0019 18.9 0.1 1.4e+02 3.3 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain Tash_PEST PF07708.11 EFC43848.1 - 0.003 17.6 11.7 15 5.9 0.2 4.4 4 0 0 4 4 4 0 Tash protein PEST motif Raf1_HTH PF18579.1 EFC43848.1 - 0.0037 16.9 0.0 1e+02 2.7 0.0 4.2 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain ORF11CD3 PF10549.9 EFC43848.1 - 0.0039 17.3 0.0 91 3.3 0.0 4.7 4 0 0 4 4 4 0 ORF11CD3 domain ACT_4 PF13291.6 EFC43848.1 - 0.0068 17.0 1.5 1.4e+02 3.2 0.0 4.2 4 0 0 4 4 4 0 ACT domain Baculo_p48 PF04878.13 EFC43848.1 - 0.035 13.0 0.0 41 3.0 0.0 3.1 3 0 0 3 3 3 0 Baculovirus P48 protein DUF493 PF04359.14 EFC43848.1 - 0.049 14.2 0.1 2.9e+02 2.1 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF493) HAMP_N3 PF18575.1 EFC43848.1 - 0.17 11.5 8.5 54 3.5 0.1 4.2 4 0 0 4 4 4 0 HAMP N-terminal domain 3 PI3K_p85B PF02192.16 EFC43848.1 - 0.23 11.2 10.7 43 3.9 0.1 4.3 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain DMA PF03474.14 EFC43848.1 - 0.26 10.9 4.0 1e+02 2.6 0.0 4.1 4 0 0 4 4 4 0 DMRTA motif Phage_sheath_1N PF17481.2 EFC43848.1 - 0.31 11.5 8.9 2.4e+03 -0.9 8.9 4.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Myosin_N PF02736.19 EFC43848.1 - 0.53 10.2 7.7 1e+02 2.8 0.1 5.3 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain Coagulin PF02035.15 EFC43848.1 - 2.2 8.1 4.6 2.2e+02 1.6 0.0 3.8 4 0 0 4 4 4 0 Coagulin NCD2 PF04905.13 EFC43849.1 - 0.0041 17.1 0.5 2.2 8.2 0.1 2.1 1 1 0 2 2 2 2 NAB conserved region 2 (NCD2) SlyX PF04102.12 EFC43849.1 - 0.14 12.8 0.8 0.24 12.1 0.8 1.3 1 0 0 1 1 1 0 SlyX Metallopep PF12044.8 EFC43850.1 - 2.3e-61 207.7 0.1 3e-61 207.3 0.1 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 EFC43850.1 - 0.017 15.3 3.2 0.03 14.5 2.7 1.6 1 1 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EFC43850.1 - 0.029 14.9 0.0 0.078 13.5 0.0 1.8 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like BTB_2 PF02214.22 EFC43851.1 - 1.5e-13 50.9 3.3 9.5e-08 32.3 0.1 3.6 3 0 0 3 3 3 2 BTB/POZ domain Homeobox_KN PF05920.11 EFC43852.1 - 1.3e-17 63.3 1.8 3.7e-17 61.9 1.6 1.9 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFC43852.1 - 6.9e-08 32.2 1.0 1.5e-07 31.2 1.0 1.5 1 0 0 1 1 1 1 Homeodomain RGS PF00615.19 EFC43853.1 - 1.2e-13 51.4 3.1 1.6e-13 51.0 1.0 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain START PF01852.19 EFC43853.1 - 0.00096 18.6 0.0 0.0022 17.4 0.0 1.7 1 1 0 1 1 1 1 START domain RCC1 PF00415.18 EFC43854.1 - 1.3e-28 99.3 4.4 2.5e-08 34.4 0.2 7.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC43854.1 - 6.2e-27 92.8 15.3 5.2e-09 35.7 0.0 6.7 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat EF1_GNE PF00736.19 EFC43855.1 - 0.037 14.2 0.4 0.38 11.0 0.0 2.7 3 0 0 3 3 3 0 EF-1 guanine nucleotide exchange domain Recep_L_domain PF01030.24 EFC43855.1 - 0.35 11.0 4.0 1.8 8.7 0.3 3.3 3 1 1 4 4 4 0 Receptor L domain HVSL PF09749.9 EFC43856.1 - 0.045 13.2 6.3 0.088 12.3 0.2 3.1 2 1 0 2 2 2 0 Uncharacterised conserved protein ApoO PF09769.9 EFC43856.1 - 0.074 13.0 0.0 0.55 10.2 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein O Ribosomal_L27e PF01777.18 EFC43857.1 - 2.3e-22 79.2 3.2 2.3e-22 79.2 3.2 1.4 2 0 0 2 2 2 1 Ribosomal L27e protein family KOW PF00467.29 EFC43857.1 - 3.9e-05 23.4 0.8 0.00025 20.9 0.0 2.4 2 1 0 2 2 2 1 KOW motif DUF4116 PF13475.6 EFC43858.1 - 4.9e-85 279.1 30.1 8.4e-14 51.0 0.0 11.5 4 1 9 14 14 14 14 Domain of unknown function (DUF4116) DUF1433 PF07252.11 EFC43858.1 - 0.033 14.4 0.7 2.1 8.6 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1433) MotCF PF09158.10 EFC43858.1 - 0.37 10.9 6.6 22 5.2 0.1 4.9 3 2 2 5 5 5 0 Bacteriophage T4 MotA, C-terminal Vint PF14623.6 EFC43859.1 - 6.5e-42 143.2 0.0 1e-41 142.5 0.0 1.3 1 0 0 1 1 1 1 Hint-domain Vwaint PF14624.6 EFC43859.1 - 3.4e-20 71.9 0.0 6.5e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 VWA / Hh protein intein-like U-box PF04564.15 EFC43859.1 - 3.7e-18 65.5 0.0 9.2e-18 64.2 0.0 1.7 1 0 0 1 1 1 1 U-box domain VWA PF00092.28 EFC43859.1 - 6.6e-15 55.8 0.0 1.9e-14 54.3 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC43859.1 - 2e-14 54.1 0.0 1.1e-13 51.8 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC43859.1 - 9.9e-11 41.8 0.0 2.7e-10 40.4 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Hint PF01079.20 EFC43859.1 - 2e-05 24.2 0.0 3.6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Hint module zf-Nse PF11789.8 EFC43859.1 - 0.00091 19.0 0.2 0.0059 16.4 0.0 2.4 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 EFC43859.1 - 0.024 14.8 0.0 0.063 13.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein DUF3977 PF13122.6 EFC43860.1 - 0.11 12.7 0.1 0.32 11.2 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3977) APH PF01636.23 EFC43861.1 - 0.00032 20.7 0.0 0.00041 20.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family BP28CT PF08146.12 EFC43861.1 - 0.1 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 BP28CT (NUC211) domain HRDC PF00570.23 EFC43861.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 HRDC domain AAA_19 PF13245.6 EFC43862.1 - 9.3e-05 22.8 0.1 0.63 10.4 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFC43862.1 - 0.025 14.8 0.2 1.2 9.5 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 EFC43862.1 - 0.064 13.7 0.1 0.45 10.9 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TarH PF02203.15 EFC43862.1 - 0.11 12.4 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 Tar ligand binding domain homologue Sec15 PF04091.12 EFC43862.1 - 0.18 11.1 5.5 0.044 13.2 0.8 2.2 3 0 0 3 3 3 0 Exocyst complex subunit Sec15-like UvrD-helicase PF00580.21 EFC43862.1 - 0.53 9.7 3.6 9.6 5.6 0.1 2.8 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain 14-3-3 PF00244.20 EFC43862.1 - 0.71 9.3 5.6 0.23 10.9 1.6 2.2 3 0 0 3 3 3 0 14-3-3 protein Rhodanese PF00581.20 EFC43863.1 - 2.8e-08 34.2 0.0 6.3e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain 2OG-FeII_Oxy_2 PF13532.6 EFC43864.1 - 2.8e-12 47.2 0.0 3.7e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC43864.1 - 0.011 16.2 0.0 0.024 15.1 0.0 1.6 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Saw1 PF11561.8 EFC43864.1 - 0.082 12.4 0.2 0.12 11.9 0.2 1.2 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Ribosomal_L13 PF00572.18 EFC43865.1 - 1.9e-06 28.1 4.5 3.6e-05 24.0 1.1 2.7 2 1 0 2 2 2 1 Ribosomal protein L13 HTH_33 PF13592.6 EFC43865.1 - 0.037 13.7 0.1 0.085 12.5 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn helix Fibrinogen_C PF00147.18 EFC43866.1 - 0.00017 21.4 0.0 0.00036 20.4 0.0 1.5 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 EFC43866.1 - 0.017 14.4 0.0 0.15 11.4 0.0 2.1 2 0 0 2 2 2 0 Fibrillar collagen C-terminal domain CCD48 PF15799.5 EFC43866.1 - 0.12 10.6 1.1 0.17 10.1 1.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 DASH_Dad2 PF08654.10 EFC43866.1 - 0.39 11.2 4.6 0.8 10.2 1.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 Macoilin PF09726.9 EFC43866.1 - 7.9 4.9 9.1 13 4.2 0.1 2.0 1 1 1 2 2 2 0 Macoilin family Mpv17_PMP22 PF04117.12 EFC43867.1 - 1e-06 28.9 0.9 2.9e-06 27.4 0.1 2.1 2 0 0 2 2 2 1 Mpv17 / PMP22 family COE1_HLH PF16423.5 EFC43867.1 - 0.17 11.6 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain Trypsin PF00089.26 EFC43869.1 - 4.2e-39 134.7 0.0 5.9e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 Trypsin DUF1986 PF09342.11 EFC43869.1 - 9.2e-05 22.8 0.1 0.00032 21.1 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) Trypsin_2 PF13365.6 EFC43869.1 - 0.0044 17.9 0.0 0.008 17.1 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain Imm30 PF15565.6 EFC43871.1 - 0.00015 21.7 2.1 0.00085 19.3 2.1 2.4 1 0 0 1 1 1 1 Immunity protein 30 ubiquitin PF00240.23 EFC43872.1 - 8.5e-09 35.1 2.6 8.6e-09 35.0 0.1 2.4 3 0 0 3 3 3 1 Ubiquitin family F-box PF00646.33 EFC43872.1 - 0.0016 18.2 0.9 0.0085 16.0 0.2 2.4 2 0 0 2 2 2 1 F-box domain Ubiquitin_2 PF14560.6 EFC43872.1 - 0.091 13.2 0.2 0.46 11.0 0.2 2.3 1 0 0 1 1 1 0 Ubiquitin-like domain PQQ_2 PF13360.6 EFC43872.1 - 0.2 11.2 0.0 0.94 9.0 0.0 2.1 2 0 0 2 2 2 0 PQQ-like domain Ras PF00071.22 EFC43873.1 - 2.2e-49 167.2 0.0 2.5e-49 167.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43873.1 - 3.1e-20 72.6 0.0 7.1e-20 71.4 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43873.1 - 7.7e-07 28.7 0.0 1.7e-06 27.6 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 EFC43873.1 - 0.051 13.1 0.4 8.4 5.9 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFC43873.1 - 0.12 12.1 0.3 1.4 8.6 0.2 2.2 2 0 0 2 2 2 0 AAA domain Rsbr_N PF08678.10 EFC43874.1 - 0.25 11.4 8.6 2.5 8.2 3.4 3.3 3 0 0 3 3 3 0 Rsbr N terminal DEAD PF00270.29 EFC43875.1 - 2e-48 164.5 0.1 2.6e-47 160.9 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC43875.1 - 7.3e-32 110.0 0.1 5.9e-30 103.9 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC43875.1 - 0.00012 22.1 0.6 0.00068 19.7 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFC43875.1 - 0.044 13.0 0.0 0.082 12.1 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SNF2_N PF00176.23 EFC43875.1 - 0.046 12.4 0.0 0.12 11.1 0.0 1.7 2 0 0 2 2 2 0 SNF2 family N-terminal domain CMS1 PF14617.6 EFC43875.1 - 3.9 6.8 7.7 2.4 7.4 0.0 2.8 2 1 1 3 3 3 0 U3-containing 90S pre-ribosomal complex subunit UQ_con PF00179.26 EFC43876.1 - 4.5e-53 178.7 0.0 5.1e-53 178.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC43876.1 - 0.0011 18.7 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFC43876.1 - 0.024 14.9 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 RWD domain zf-RING_5 PF14634.6 EFC43877.1 - 1.2e-08 34.7 7.2 2.1e-08 34.0 7.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFC43877.1 - 0.0021 17.9 9.0 0.0066 16.3 9.0 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC43877.1 - 0.0096 15.8 6.1 0.021 14.7 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CortBP2 PF09727.9 EFC43877.1 - 0.011 15.7 0.5 0.021 14.7 0.5 1.4 1 0 0 1 1 1 0 Cortactin-binding protein-2 zf-RING_UBOX PF13445.6 EFC43877.1 - 0.026 14.5 5.0 0.076 13.1 5.0 1.9 1 0 0 1 1 1 0 RING-type zinc-finger Phage_HK97_TLTM PF06120.11 EFC43877.1 - 0.14 11.3 3.1 3.9 6.6 0.6 2.8 2 2 0 2 2 2 0 Tail length tape measure protein zf-RING_2 PF13639.6 EFC43877.1 - 0.15 12.4 6.2 0.28 11.5 6.2 1.5 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 EFC43877.1 - 0.87 9.5 7.9 1.9 8.4 7.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFC43877.1 - 4.5 7.5 10.6 15 5.9 10.6 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFC43877.1 - 4.6 7.2 10.1 0.28 11.0 2.9 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) EF-hand_1 PF00036.32 EFC43878.1 - 1.3e-32 108.9 12.4 9.8e-09 34.2 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFC43878.1 - 2e-29 101.2 11.4 1.4e-13 50.5 0.3 4.1 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_7 PF13499.6 EFC43878.1 - 2.4e-29 101.6 6.1 2.9e-16 59.7 2.3 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC43878.1 - 1.3e-24 83.9 8.4 3.7e-08 32.7 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFC43878.1 - 2.5e-19 67.8 10.6 2.8e-06 26.6 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EFC43878.1 - 3.1e-17 62.7 0.1 2.9e-07 30.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC43878.1 - 4e-10 40.0 0.4 1e-05 25.8 0.3 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC43878.1 - 5.5e-08 32.7 2.2 0.00022 21.1 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EFC43878.1 - 7.4e-05 22.7 3.4 0.81 9.6 0.0 3.7 1 1 3 4 4 4 2 Caleosin related protein TerB PF05099.13 EFC43878.1 - 8.9e-05 22.5 0.2 0.34 10.8 0.0 2.2 2 0 0 2 2 2 2 Tellurite resistance protein TerB Dockerin_1 PF00404.18 EFC43878.1 - 0.00033 20.8 3.7 0.054 13.7 0.1 3.0 1 1 2 3 3 3 2 Dockerin type I domain EF-hand_11 PF08976.11 EFC43878.1 - 0.0011 19.8 0.4 0.018 15.9 0.1 2.2 1 1 1 2 2 2 1 EF-hand domain Lipoprotein_Ltp PF07553.11 EFC43878.1 - 0.0047 17.2 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 Host cell surface-exposed lipoprotein SurA_N_3 PF13624.6 EFC43878.1 - 0.012 15.4 0.9 0.027 14.3 0.3 1.8 2 0 0 2 2 2 0 SurA N-terminal domain EF-hand_14 PF17959.1 EFC43878.1 - 0.016 15.5 0.2 0.24 11.8 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain UPF0154 PF03672.13 EFC43878.1 - 0.02 14.9 0.1 9.4 6.4 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 EFC43878.1 - 0.048 13.7 0.3 0.16 12.1 0.1 2.0 2 0 0 2 2 2 0 Ca2+ insensitive EF hand SapB_1 PF05184.15 EFC43878.1 - 0.059 13.4 1.0 0.19 11.8 0.4 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 1 Fe_hyd_lg_C PF02906.14 EFC43878.1 - 0.091 12.4 0.9 3.2 7.3 0.2 2.0 1 1 1 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain DUF3349 PF11829.8 EFC43878.1 - 0.19 12.5 0.2 5.1 7.9 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) MLANA PF14991.6 EFC43879.1 - 0.00015 22.0 0.0 0.00015 22.0 0.0 2.7 3 1 1 4 4 4 1 Protein melan-A ETRAMP PF09716.10 EFC43879.1 - 0.02 15.0 0.3 0.02 15.0 0.3 3.6 2 1 2 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) Neurensin PF14927.6 EFC43879.1 - 0.022 14.4 0.6 0.022 14.4 0.6 3.2 3 2 1 4 4 4 0 Neurensin WBP-1 PF11669.8 EFC43879.1 - 0.064 13.9 1.8 0.33 11.6 0.1 2.9 3 0 0 3 3 3 0 WW domain-binding protein 1 DUF1345 PF07077.11 EFC43879.1 - 0.13 11.9 7.4 0.97 9.1 3.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1345) Cadherin_C_2 PF16492.5 EFC43879.1 - 0.17 12.6 0.1 0.17 12.6 0.1 2.6 2 1 0 2 2 1 0 Cadherin cytoplasmic C-terminal Renin_r PF07850.14 EFC43879.1 - 0.24 12.0 0.2 0.24 12.0 0.2 3.4 4 2 1 5 5 5 0 Renin receptor-like protein EphA2_TM PF14575.6 EFC43879.1 - 0.88 10.5 0.1 0.88 10.5 0.1 4.1 4 2 1 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.6 EFC43879.1 - 1.2 8.9 8.3 3 7.6 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF4448) E1-E2_ATPase PF00122.20 EFC43879.1 - 1.7 8.1 7.8 0.54 9.8 0.8 3.1 2 1 0 3 3 3 0 E1-E2 ATPase LRRC37AB_C PF14914.6 EFC43879.1 - 2.1 8.3 12.0 1.5 8.7 0.1 3.5 2 1 1 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain DHHC PF01529.20 EFC43879.1 - 3.2 7.9 22.6 2.3 8.4 4.1 3.7 1 1 3 4 4 4 0 DHHC palmitoyltransferase F-box PF00646.33 EFC43880.1 - 0.0013 18.6 0.2 0.0036 17.2 0.2 1.8 1 0 0 1 1 1 1 F-box domain SR-25 PF10500.9 EFC43880.1 - 0.95 9.0 9.3 1.5 8.3 9.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein LRS4 PF10422.9 EFC43880.1 - 2.2 7.8 10.3 0.88 9.1 7.8 1.5 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 DIL PF01843.19 EFC43881.1 - 2.7e-13 50.1 0.4 2.7e-13 50.1 0.4 4.0 4 0 0 4 4 4 1 DIL domain Spc7 PF08317.11 EFC43881.1 - 7.7e-05 21.7 76.3 0.00024 20.1 34.5 9.0 1 1 8 9 9 9 4 Spc7 kinetochore protein DUF4200 PF13863.6 EFC43881.1 - 0.00045 20.6 23.8 0.00045 20.6 23.8 13.2 3 2 8 12 12 12 4 Domain of unknown function (DUF4200) DUF948 PF06103.11 EFC43881.1 - 0.0035 17.6 2.1 0.0035 17.6 2.1 12.5 5 2 8 13 13 13 1 Bacterial protein of unknown function (DUF948) ATG16 PF08614.11 EFC43881.1 - 0.0052 17.0 17.6 0.0052 17.0 17.6 9.7 1 1 8 10 10 10 4 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 EFC43881.1 - 0.0089 16.2 24.6 0.0089 16.2 24.6 11.4 2 2 10 12 12 12 3 Tropomyosin like DUF4116 PF13475.6 EFC43882.1 - 1e-57 191.7 35.6 1.1e-08 34.6 1.1 11.1 6 3 7 13 13 13 12 Domain of unknown function (DUF4116) PI3Ka PF00613.20 EFC43882.1 - 0.026 14.0 0.2 0.069 12.5 0.1 1.8 2 0 0 2 2 2 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Pkinase PF00069.25 EFC43883.1 - 1.9e-61 207.8 0.0 2.1e-61 207.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43883.1 - 7e-35 120.6 0.0 8.5e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43883.1 - 3.2e-08 32.8 0.0 5e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC43883.1 - 4.3e-05 23.5 0.0 0.00039 20.4 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC43883.1 - 0.0019 17.6 0.0 0.0041 16.5 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC43883.1 - 0.006 15.6 0.3 0.019 13.9 0.3 1.7 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFC43883.1 - 0.037 13.6 0.2 0.071 12.7 0.2 1.5 1 1 0 1 1 1 0 RIO1 family Kdo PF06293.14 EFC43883.1 - 0.077 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ADC PF06314.11 EFC43884.1 - 3.7e-109 363.8 0.0 8.5e-64 215.3 0.0 2.0 2 0 0 2 2 2 2 Acetoacetate decarboxylase (ADC) ubiquitin PF00240.23 EFC43885.1 - 0.00038 20.2 0.0 0.0011 18.6 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin family F-box-like PF12937.7 EFC43885.1 - 0.0035 17.2 0.4 0.0074 16.2 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC43885.1 - 0.11 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 F-box domain zf-C3HC4_3 PF13920.6 EFC43887.1 - 3e-07 30.2 15.8 1.6e-05 24.7 12.1 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC43887.1 - 0.032 14.1 17.1 2.6 8.0 0.0 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Rab5ip PF07019.12 EFC43887.1 - 1.7 9.3 5.7 0.6 10.7 2.2 2.0 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Neur_chan_memb PF02932.16 EFC43888.1 - 0.045 13.8 2.5 0.065 13.3 2.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 EFC43888.1 - 0.16 10.2 12.8 0.21 9.9 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein EMC3_TMCO1 PF01956.16 EFC43888.1 - 0.69 9.6 6.3 0.09 12.5 1.5 1.8 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like PEX11 PF05648.14 EFC43888.1 - 0.96 8.9 6.8 2.4 7.6 6.9 1.9 1 1 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Spexin PF15171.6 EFC43888.1 - 7.9 6.8 9.2 0.57 10.4 2.1 2.2 1 1 1 2 2 2 0 Neuropeptide secretory protein family, NPQ, spexin PH PF00169.29 EFC43889.1 - 9.5e-18 64.6 0.1 2.2e-17 63.5 0.1 1.6 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EFC43889.1 - 4.3e-07 30.0 0.1 1.8e-06 28.0 0.1 2.0 2 0 0 2 2 2 1 PH domain Beta_helix PF13229.6 EFC43889.1 - 7.3e-06 25.9 0.1 0.00011 22.1 0.1 2.4 1 1 1 2 2 2 1 Right handed beta helix region NosD PF05048.13 EFC43889.1 - 1.5e-05 24.4 0.0 3.9e-05 23.0 0.0 1.6 2 0 0 2 2 2 1 Periplasmic copper-binding protein (NosD) PH_8 PF15409.6 EFC43889.1 - 0.0024 18.1 0.0 0.0048 17.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFC43889.1 - 0.0025 18.2 0.8 0.067 13.6 0.8 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Pkinase PF00069.25 EFC43890.1 - 2.7e-52 177.8 0.0 3.2e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43890.1 - 2.1e-31 109.2 0.0 5.7e-31 107.7 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC43890.1 - 0.02 14.2 0.0 0.043 13.1 0.0 1.6 1 1 0 1 1 1 0 Kinase-like ISP3_C PF18045.1 EFC43890.1 - 0.12 12.3 0.1 2 8.3 0.0 2.6 3 0 0 3 3 3 0 ISP3 C-terminal Kdo PF06293.14 EFC43890.1 - 0.14 11.5 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_2 PF07719.17 EFC43891.1 - 7.8e-11 41.2 20.4 9.5e-05 22.2 1.6 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC43891.1 - 5.5e-09 35.5 22.7 1.1e-05 25.0 2.3 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC43891.1 - 3.8e-06 26.7 16.9 0.0017 18.4 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC43891.1 - 5.3e-05 23.4 12.4 0.00014 22.1 1.3 3.8 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC43891.1 - 0.00024 21.7 4.5 0.0014 19.2 0.3 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat F-box PF00646.33 EFC43891.1 - 0.0011 18.8 0.1 0.0033 17.2 0.1 1.8 1 0 0 1 1 1 1 F-box domain TPR_11 PF13414.6 EFC43891.1 - 0.019 14.7 9.0 0.7 9.6 0.1 5.0 5 0 0 5 5 5 0 TPR repeat F-box-like PF12937.7 EFC43891.1 - 0.032 14.1 0.2 0.084 12.8 0.0 1.7 2 0 0 2 2 2 0 F-box-like TPR_9 PF13371.6 EFC43891.1 - 0.036 14.2 2.6 13 6.0 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC43891.1 - 0.046 13.1 0.2 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 MalT-like TPR region ANAPC3 PF12895.7 EFC43891.1 - 3 8.1 10.3 1.2 9.4 3.5 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Nucleoside_tran PF01733.18 EFC43892.1 - 2.5e-51 174.9 29.5 5.2e-51 173.9 25.7 2.3 2 1 0 2 2 2 1 Nucleoside transporter Pox_G7 PF05503.12 EFC43892.1 - 0.0092 15.0 1.6 0.014 14.3 1.6 1.2 1 0 0 1 1 1 1 Poxvirus G7-like Presenilin PF01080.17 EFC43893.1 - 0.95 8.2 4.8 1.1 8.0 4.8 1.2 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 EFC43893.1 - 1.9 7.8 10.2 2.4 7.4 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) O-antigen_lig PF13425.6 EFC43893.1 - 4.3 6.0 7.2 4.9 5.8 7.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ras PF00071.22 EFC43894.1 - 9.4e-30 103.4 0.2 1.7e-29 102.5 0.2 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC43894.1 - 1.5e-20 73.6 0.0 4e-20 72.2 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC43894.1 - 7.1e-08 32.1 0.0 1.3e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box-like PF12937.7 EFC43894.1 - 9.5e-07 28.6 0.3 2.3e-06 27.4 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC43894.1 - 1.3e-05 24.9 0.6 3.3e-05 23.7 0.6 1.6 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 EFC43894.1 - 7.4e-05 22.2 0.9 0.0003 20.2 0.1 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Toxin_ToxA PF11584.8 EFC43895.1 - 0.026 14.5 2.4 0.045 13.7 0.5 2.3 3 0 0 3 3 3 0 Proteinaceous host-selective toxin ToxA Motile_Sperm PF00635.26 EFC43895.1 - 0.17 11.8 0.1 0.37 10.7 0.1 1.5 1 0 0 1 1 1 0 MSP (Major sperm protein) domain EGF_2 PF07974.13 EFC43896.1 - 1.5e-46 156.4 262.5 3.7e-05 24.0 4.9 17.7 17 0 0 17 17 17 17 EGF-like domain EGF PF00008.27 EFC43896.1 - 0.0098 16.2 3.2 0.0098 16.2 3.2 17.9 18 0 0 18 18 18 12 EGF-like domain GTP_EFTU PF00009.27 EFC43897.1 - 1.6e-58 197.5 0.1 5.1e-58 195.8 0.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFC43897.1 - 4.1e-21 74.8 0.0 1.1e-20 73.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 EFC43897.1 - 6e-20 71.2 0.0 1.2e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 EFC43897.1 - 4e-13 49.2 0.0 8.9e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFC43897.1 - 1.1e-10 41.8 0.0 3e-10 40.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFC43897.1 - 0.0005 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFC43897.1 - 0.0074 16.4 0.1 0.017 15.2 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MycE_N PF17843.1 EFC43897.1 - 0.13 12.8 0.1 30 5.1 0.0 2.5 2 0 0 2 2 2 0 MycE methyltransferase N-terminal Arf PF00025.21 EFC43898.1 - 1.1e-63 213.8 0.1 1.2e-63 213.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC43898.1 - 1e-13 51.2 0.0 1.1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC43898.1 - 9.7e-12 44.7 1.1 1.7e-08 34.1 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFC43898.1 - 1.2e-11 44.9 0.0 1.6e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC43898.1 - 7.2e-10 38.6 0.0 8.8e-10 38.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC43898.1 - 4.8e-07 29.4 0.0 6.1e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC43898.1 - 0.00024 21.2 0.0 0.00034 20.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4116 PF13475.6 EFC43899.1 - 4.3e-28 96.8 11.3 8.1e-10 38.3 0.3 3.9 2 2 2 4 4 4 4 Domain of unknown function (DUF4116) Met_synt_B12 PF02965.17 EFC43899.1 - 0.00095 18.7 0.0 0.0017 17.9 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Ribosomal_L26 PF16906.5 EFC43901.1 - 3.3e-31 107.6 1.5 4.1e-31 107.3 1.5 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 EFC43901.1 - 7e-06 25.8 4.4 7e-06 25.8 4.4 1.9 2 0 0 2 2 2 1 KOW motif Exo_endo_phos PF03372.23 EFC43902.1 - 0.072 12.6 0.0 0.1 12.1 0.0 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ribosomal_L18_c PF14204.6 EFC43903.1 - 0.2 12.6 2.1 2.2 9.3 0.1 3.3 3 0 0 3 3 3 0 Ribosomal L18 C-terminal region PAD_porph PF04371.15 EFC43904.1 - 4.9e-40 137.8 0.0 5.5e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase zf-Nse PF11789.8 EFC43905.1 - 1.1e-14 54.0 0.1 2.4e-14 52.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit CDV3 PF15359.6 EFC43905.1 - 0.0083 16.6 1.2 0.012 16.1 0.1 1.8 2 0 0 2 2 2 1 Carnitine deficiency-associated protein 3 zf-MIZ PF02891.20 EFC43905.1 - 0.0099 15.6 0.6 0.019 14.7 0.6 1.5 1 1 0 1 1 1 1 MIZ/SP-RING zinc finger MetOD1 PF18546.1 EFC43905.1 - 0.013 15.5 0.1 0.027 14.4 0.1 1.6 1 0 0 1 1 1 0 Metanogen output domain 1 Pox_VP8_L4R PF04498.12 EFC43905.1 - 0.016 14.8 0.2 0.036 13.7 0.2 1.6 1 0 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R UPF0542 PF15086.6 EFC43905.1 - 0.02 14.8 0.4 0.041 13.8 0.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Pyrid_ox_like PF16242.5 EFC43906.1 - 1.3e-34 118.9 0.0 1.6e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 EFC43906.1 - 5.2e-12 45.8 0.0 1.5e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 EFC43906.1 - 0.0015 18.3 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Putative FMN-binding domain Zn_clus PF00172.18 EFC43907.1 - 1.7e-05 24.8 14.0 4.4e-05 23.5 14.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.6 EFC43907.1 - 1.4 8.5 20.7 1.5 8.4 13.4 3.0 1 1 2 3 3 3 0 PHD/FYVE-zinc-finger like domain DUF2373 PF10180.9 EFC43908.1 - 2.3e-15 56.2 0.3 4.3e-15 55.3 0.3 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) GHMP_kinases_N PF00288.26 EFC43909.1 - 5.9e-14 52.1 0.3 1.3e-13 51.0 0.1 1.8 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 EFC43909.1 - 2.3e-06 27.9 0.0 2.9e-05 24.3 0.0 2.4 2 0 0 2 2 2 1 GHMP kinases C terminal Cor1 PF04803.12 EFC43909.1 - 1.4 9.1 5.2 3.1 8.0 0.9 3.0 2 1 1 3 3 3 0 Cor1/Xlr/Xmr conserved region zf-CRD PF17979.1 EFC43911.1 - 5.9e-27 94.7 20.8 5.9e-27 94.7 20.8 2.4 2 0 0 2 2 2 1 Cysteine rich domain with multizinc binding regions FHA PF00498.26 EFC43911.1 - 2.9e-09 37.1 0.3 1.1e-08 35.3 0.0 2.2 2 0 0 2 2 2 1 FHA domain zf-C3HC4 PF00097.25 EFC43911.1 - 3e-08 33.4 7.3 3e-08 33.4 7.3 4.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC43911.1 - 7.7e-08 32.2 6.3 7.7e-08 32.2 6.3 3.2 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC43911.1 - 8.2e-08 32.0 6.4 8.2e-08 32.0 6.4 4.5 3 1 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC43911.1 - 1.9e-07 31.3 7.3 1.9e-07 31.3 7.3 4.2 4 1 0 4 4 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFC43911.1 - 2.3e-07 30.6 4.1 2.3e-07 30.6 4.1 4.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHH PF10283.9 EFC43911.1 - 6.1e-07 29.3 1.5 3.2e-06 27.0 1.5 2.3 1 0 0 1 1 1 1 PBZ domain zf-C3HC4_4 PF15227.6 EFC43911.1 - 9.8e-06 25.6 10.0 9.8e-06 25.6 10.0 4.0 4 0 0 4 4 3 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFC43911.1 - 1.8e-05 24.6 4.9 1.8e-05 24.6 4.9 4.7 3 2 1 4 4 3 1 zinc-RING finger domain FYVE PF01363.21 EFC43911.1 - 0.00026 21.1 23.5 0.11 12.7 10.4 3.7 3 0 0 3 3 3 3 FYVE zinc finger FHA_2 PF17913.1 EFC43911.1 - 0.00035 20.8 0.0 0.0016 18.6 0.0 2.1 1 1 0 1 1 1 1 FHA domain zf-Nse PF11789.8 EFC43911.1 - 0.05 13.4 2.4 0.14 12.0 2.4 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Coa1 PF08695.10 EFC43911.1 - 0.065 13.0 0.0 1.2 9.0 0.0 2.5 3 0 0 3 3 3 0 Cytochrome oxidase complex assembly protein 1 zf-FPG_IleRS PF06827.14 EFC43911.1 - 0.33 10.9 0.1 0.33 10.9 0.1 3.6 3 1 0 3 3 2 0 Zinc finger found in FPG and IleRS CDC45 PF02724.14 EFC43911.1 - 6 5.0 8.1 8.5 4.5 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-RING_6 PF14835.6 EFC43911.1 - 6.5 6.7 15.7 0.024 14.5 5.0 2.6 2 1 0 2 2 1 0 zf-RING of BARD1-type protein SPT2 PF08243.11 EFC43912.1 - 4.1e-14 53.0 20.9 4.1e-14 53.0 20.9 2.8 3 0 0 3 3 3 1 SPT2 chromatin protein YL1 PF05764.13 EFC43912.1 - 0.013 15.6 14.8 0.013 15.6 14.8 3.3 2 1 0 2 2 2 0 YL1 nuclear protein GH97_C PF14509.6 EFC43912.1 - 0.13 12.5 0.3 0.13 12.5 0.3 3.0 4 0 0 4 4 4 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation SieB PF14163.6 EFC43913.1 - 0.1 12.1 0.0 0.27 10.7 0.0 1.8 1 0 0 1 1 1 0 Super-infection exclusion protein B YlaC PF10777.9 EFC43913.1 - 0.38 10.6 4.0 0.092 12.6 0.7 1.6 2 0 0 2 2 2 0 Inner membrane protein YlaC CH PF00307.31 EFC43914.1 - 3.7e-09 36.7 0.4 1.3e-08 35.0 0.3 2.1 1 1 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFC43914.1 - 0.0024 17.7 0.1 0.0078 16.0 0.0 1.9 2 0 0 2 2 2 1 CAMSAP CH domain CASP_C PF08172.12 EFC43914.1 - 0.019 14.3 0.4 0.036 13.4 0.4 1.5 1 0 0 1 1 1 0 CASP C terminal Mtc PF03820.17 EFC43915.1 - 4.8e-114 380.6 2.8 5.5e-114 380.4 2.8 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier TIG PF01833.24 EFC43916.1 - 6.3e-09 35.8 3.6 8e-09 35.5 0.2 3.2 2 0 0 2 2 2 1 IPT/TIG domain Ntox1 PF15500.6 EFC43917.1 - 0.18 12.1 6.5 0.082 13.3 1.6 2.2 1 1 1 2 2 2 0 Putative RNase-like toxin, toxin_1 NAP PF00956.18 EFC43917.1 - 6.3 5.9 15.1 10 5.2 15.1 1.5 1 1 0 1 1 1 0 Nucleosome assembly protein (NAP) CTP_transf_like PF01467.26 EFC43918.1 - 1.2e-25 90.4 0.0 1.8e-25 89.8 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF5639 PF18690.1 EFC43918.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5639) FAD_binding_1 PF00667.20 EFC43919.1 - 2.3e-49 167.9 0.0 3.5e-49 167.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFC43919.1 - 3.5e-31 108.3 0.0 6.5e-31 107.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFC43919.1 - 1.7e-14 54.4 0.0 4.9e-14 52.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 EFC43919.1 - 0.00036 20.8 0.1 0.74 10.0 0.0 2.8 2 1 1 3 3 3 2 Flavodoxin domain Flavodoxin_3 PF12641.7 EFC43919.1 - 0.14 11.8 0.1 1.5 8.5 0.0 2.6 3 0 0 3 3 3 0 Flavodoxin domain Pro_isomerase PF00160.21 EFC43920.1 - 4e-35 121.4 0.8 4.4e-35 121.3 0.8 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Bunya_G2 PF03563.13 EFC43921.1 - 0.0025 17.1 0.3 0.0058 15.9 0.3 1.5 1 0 0 1 1 1 1 Bunyavirus glycoprotein G2 Baculo_11_kDa PF06143.11 EFC43921.1 - 0.0026 17.3 4.9 0.18 11.4 0.3 2.6 2 0 0 2 2 2 2 Baculovirus 11 kDa family RGS PF00615.19 EFC43921.1 - 0.03 14.6 1.3 0.03 14.6 1.3 2.2 2 1 0 2 2 2 0 Regulator of G protein signaling domain Mating_N PF12731.7 EFC43921.1 - 0.17 12.0 1.8 36 4.5 0.0 3.5 3 0 0 3 3 3 0 Mating-type protein beta 1 DUF5383 PF17355.2 EFC43921.1 - 0.24 11.8 5.5 0.42 11.0 0.5 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5383) SIT PF15330.6 EFC43921.1 - 1.8 9.1 5.0 0.4 11.1 0.2 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT EF-hand_8 PF13833.6 EFC43922.1 - 8.3e-20 70.4 0.2 8.8e-15 54.3 0.2 3.2 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC43922.1 - 1.4e-19 68.1 0.4 4e-09 35.4 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFC43922.1 - 9.2e-17 61.3 0.1 1.1e-13 51.4 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC43922.1 - 3.6e-12 45.2 0.1 0.00011 21.8 0.0 3.5 4 1 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EFC43922.1 - 1.3e-09 37.1 1.5 0.00018 20.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 EFC43922.1 - 1.5e-09 38.0 0.0 1.4e-07 31.7 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_4 PF12763.7 EFC43922.1 - 4.4e-06 26.6 0.0 1.1e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand UPF0154 PF03672.13 EFC43922.1 - 0.0019 18.2 0.1 0.0035 17.3 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0154) SPARC_Ca_bdg PF10591.9 EFC43922.1 - 0.007 16.7 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EFC43922.1 - 0.054 13.4 0.2 4.4 7.2 0.0 2.4 1 1 1 2 2 2 0 EF hand TerB PF05099.13 EFC43922.1 - 0.055 13.4 0.3 0.18 11.8 0.1 1.9 1 1 1 2 2 2 0 Tellurite resistance protein TerB Herpes_UL36 PF03586.13 EFC43922.1 - 0.1 11.9 0.3 0.21 10.9 0.2 1.6 1 1 1 2 2 2 0 Herpesvirus UL36 tegument protein Surface_antigen PF11054.8 EFC43922.1 - 0.11 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen Pyr_redox_2 PF07992.14 EFC43923.1 - 3.7e-62 210.2 1.0 4.8e-62 209.8 1.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC43923.1 - 5.6e-18 65.3 9.7 5e-17 62.2 0.2 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Rhodanese PF00581.20 EFC43923.1 - 2.8e-17 63.2 0.0 5.3e-16 59.1 0.0 2.7 3 0 0 3 3 3 1 Rhodanese-like domain Pyr_redox_dim PF02852.22 EFC43923.1 - 7e-14 52.0 0.9 4.1e-12 46.4 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 EFC43923.1 - 3e-10 39.8 0.8 4.1e-09 36.1 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC43923.1 - 4.6e-07 30.0 0.1 0.013 15.7 0.1 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 EFC43923.1 - 0.00061 19.0 0.2 0.0013 17.9 0.0 1.6 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 EFC43923.1 - 0.0024 16.7 6.9 1.9 7.1 0.0 4.1 3 1 1 4 4 4 1 HI0933-like protein NAD_binding_9 PF13454.6 EFC43923.1 - 0.0029 17.6 5.2 4.8 7.2 0.0 4.1 3 1 1 4 4 4 1 FAD-NAD(P)-binding ThiF PF00899.21 EFC43923.1 - 0.0035 16.7 0.3 0.13 11.6 0.1 2.3 2 0 0 2 2 2 1 ThiF family Lycopene_cycl PF05834.12 EFC43923.1 - 0.0074 15.4 3.4 0.94 8.5 0.3 3.0 2 1 1 3 3 3 1 Lycopene cyclase protein TrkA_N PF02254.18 EFC43923.1 - 0.011 16.0 0.6 2.7 8.3 0.0 3.2 2 1 0 2 2 2 0 TrkA-N domain Amino_oxidase PF01593.24 EFC43923.1 - 0.018 14.3 0.3 0.092 12.0 0.0 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase DAO PF01266.24 EFC43923.1 - 0.027 14.1 11.2 5.4 6.5 2.4 4.1 3 1 1 4 4 4 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 EFC43923.1 - 0.12 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 EFC43923.1 - 0.14 11.2 6.5 3.7 6.5 0.1 3.2 3 0 0 3 3 3 0 FAD binding domain NAD_binding_7 PF13241.6 EFC43923.1 - 0.15 12.5 0.4 3.7 8.0 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding GIDA PF01134.22 EFC43923.1 - 0.21 10.7 10.3 0.34 9.9 0.9 3.1 2 2 1 3 3 3 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 EFC43923.1 - 4.1 6.1 4.6 10 4.9 0.1 2.7 3 0 0 3 3 3 0 Tryptophan halogenase Sec1 PF00995.23 EFC43924.1 - 1e-125 421.2 16.8 1.3e-125 420.9 16.8 1.1 1 0 0 1 1 1 1 Sec1 family TEX13 PF15186.6 EFC43924.1 - 0.049 13.3 0.8 0.097 12.4 0.8 1.5 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Costars PF14705.6 EFC43924.1 - 0.078 13.2 0.0 0.67 10.2 0.0 2.5 2 0 0 2 2 2 0 Costars Oxidored_q6 PF01058.22 EFC43924.1 - 0.1 12.4 0.0 0.34 10.7 0.0 1.8 1 0 0 1 1 1 0 NADH ubiquinone oxidoreductase, 20 Kd subunit FRB_dom PF08771.11 EFC43924.1 - 0.14 12.6 2.5 14 6.1 0.0 3.0 1 1 1 2 2 2 0 FKBP12-rapamycin binding domain DUF3642 PF12182.8 EFC43925.1 - 0.02 15.1 2.8 0.1 12.9 0.4 2.9 2 1 0 2 2 2 0 Bacterial lipoprotein DsbD_2 PF13386.6 EFC43925.1 - 0.035 14.0 0.7 0.054 13.4 0.7 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region ELO PF01151.18 EFC43926.1 - 1.4e-42 146.0 19.2 1.6e-42 145.8 19.2 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family WD40 PF00400.32 EFC43927.1 - 1.4e-31 108.0 9.9 1.6e-08 35.1 0.0 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 EFC43927.1 - 1e-26 92.9 0.7 5.1e-26 90.7 0.6 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 EFC43927.1 - 2.1e-07 31.2 1.1 0.008 16.5 0.1 4.3 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF4849 PF16141.5 EFC43928.1 - 0.0072 15.6 2.9 0.0082 15.4 2.9 1.1 1 0 0 1 1 1 1 Putative glycoside hydrolase Family 18, chitinase_18 BshC PF10079.9 EFC43928.1 - 0.026 13.3 5.7 0.031 13.0 5.7 1.1 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC Apolipoprotein PF01442.18 EFC43928.1 - 0.038 13.9 4.2 0.063 13.2 3.2 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Exonuc_VII_L PF02601.15 EFC43928.1 - 0.31 10.6 2.9 0.33 10.5 2.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spore_II_R PF09551.10 EFC43928.1 - 0.72 10.3 4.0 24 5.4 0.0 2.5 2 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) Zn_ribbon_2 PF12674.7 EFC43928.1 - 1.2 9.8 3.7 1.9 9.2 0.7 2.3 1 1 1 2 2 2 0 Putative zinc ribbon domain ABC1 PF03109.16 EFC43929.1 - 2.4e-27 95.5 0.6 5.6e-27 94.3 0.1 1.9 2 0 0 2 2 2 1 ABC1 family RIO1 PF01163.22 EFC43929.1 - 0.0017 18.0 2.4 0.0096 15.5 2.4 2.1 1 1 0 1 1 1 1 RIO1 family Pkinase PF00069.25 EFC43929.1 - 0.016 14.6 0.5 0.16 11.3 0.3 2.3 2 0 0 2 2 2 0 Protein kinase domain Sod_Cu PF00080.20 EFC43930.1 - 1.6e-35 122.3 2.3 1.8e-35 122.2 2.3 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) BRCT_2 PF16589.5 EFC43931.1 - 9.3e-20 70.8 5.4 4e-09 36.8 0.1 4.6 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFC43931.1 - 2.1e-16 60.1 0.3 2.3e-10 40.7 0.1 5.2 5 2 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFC43931.1 - 3.5e-14 52.5 0.1 8.7e-10 38.4 0.0 3.6 3 0 0 3 3 3 2 twin BRCT domain HMG_box PF00505.19 EFC43931.1 - 7.6e-09 35.9 5.4 7.6e-09 35.9 5.4 5.0 4 1 0 4 4 4 1 HMG (high mobility group) box RTT107_BRCT_5 PF16770.5 EFC43931.1 - 0.00022 21.1 0.0 0.00022 21.1 0.0 7.0 5 2 2 8 8 8 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EFC43931.1 - 0.00072 19.8 0.1 0.0043 17.3 0.4 5.7 6 1 0 6 6 6 2 DNA ligase 3 BRCT domain WD40 PF00400.32 EFC43932.1 - 5.9e-06 26.9 11.7 2.1 9.4 0.0 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.11 EFC43932.1 - 0.0071 16.2 4.5 5 7.0 0.1 3.7 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EFC43932.1 - 0.016 13.7 0.1 0.29 9.6 0.0 2.5 2 1 1 3 3 3 0 Cytochrome D1 heme domain Exonuc_VII_L PF02601.15 EFC43932.1 - 4.1 6.9 6.9 11 5.4 6.9 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit RNA_pol_Rpb2_2 PF04561.14 EFC43933.1 - 0.35 10.5 7.1 0.12 11.9 3.7 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 2 Drf_FH1 PF06346.12 EFC43934.1 - 1.8e-06 27.8 26.9 1.8e-06 27.8 26.9 2.5 2 0 0 2 2 2 1 Formin Homology Region 1 Mucin PF01456.17 EFC43934.1 - 0.0052 16.8 26.8 0.0052 16.8 26.8 8.6 6 2 0 6 6 6 1 Mucin-like glycoprotein UPF0259 PF06790.11 EFC43934.1 - 0.36 10.6 1.9 0.63 9.8 1.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0259) ALGX PF16822.5 EFC43934.1 - 9.6 5.8 10.5 3.2 7.4 1.4 3.7 3 0 0 3 3 3 0 SGNH hydrolase-like domain, acetyltransferase AlgX Gal_mutarotas_2 PF13802.6 EFC43935.1 - 0.019 15.3 2.3 0.032 14.6 2.3 1.4 1 0 0 1 1 1 0 Galactose mutarotase-like Ras PF00071.22 EFC43937.1 - 3.8e-11 42.9 0.6 9e-11 41.6 0.2 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC43937.1 - 4e-10 40.0 1.6 2.4e-09 37.4 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC43937.1 - 8.2e-07 28.8 0.5 2.3e-06 27.4 0.5 1.8 1 0 0 1 1 1 1 F-box-like Arf PF00025.21 EFC43937.1 - 6.2e-06 25.8 1.3 8.3e-06 25.4 0.2 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family F-box PF00646.33 EFC43937.1 - 4.1e-05 23.3 0.1 0.0001 22.1 0.1 1.6 1 0 0 1 1 1 1 F-box domain RsgA_GTPase PF03193.16 EFC43937.1 - 0.0057 16.6 0.3 0.18 11.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC43937.1 - 0.11 12.6 0.1 0.35 11.0 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC43937.1 - 0.12 12.2 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cas9_b_hairpin PF17893.1 EFC43937.1 - 0.15 11.9 0.0 9.2 6.1 0.0 2.5 2 0 0 2 2 2 0 CRISPR-associated endonuclease Cas9 beta-hairpin domain Terminase_1 PF03354.15 EFC43938.1 - 0.052 12.1 0.1 0.053 12.1 0.1 1.1 1 0 0 1 1 1 0 Phage Terminase GRDP-like PF07173.12 EFC43939.1 - 0.0069 17.0 0.1 0.012 16.3 0.1 1.5 1 0 0 1 1 1 1 Glycine-rich domain-containing protein-like SoDot-IcmSS PF16848.5 EFC43939.1 - 0.058 13.4 0.4 0.096 12.7 0.4 1.3 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative adh_short PF00106.25 EFC43940.1 - 1e-28 100.1 0.0 6.2e-21 74.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43940.1 - 3.8e-21 75.7 0.0 1e-18 67.8 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43940.1 - 5.3e-05 23.2 0.0 8.2e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 EFC43940.1 - 0.0029 17.1 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase SPOUT_MTase PF02590.17 EFC43940.1 - 0.077 13.0 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase EGF_2 PF07974.13 EFC43941.1 - 8.1e-18 64.5 188.8 0.0002 21.7 10.0 13.7 13 1 0 13 13 13 9 EGF-like domain DUF1697 PF08002.11 EFC43942.1 - 8.4e-30 104.0 1.3 1.8e-17 64.1 0.0 2.4 3 0 0 3 3 3 2 Protein of unknown function (DUF1697) MALT1_Ig PF18703.1 EFC43942.1 - 0.54 10.3 3.1 14 5.7 0.1 2.1 1 1 1 2 2 2 0 MALT1 Ig-like domain Pkinase PF00069.25 EFC43943.1 - 8.5e-60 202.3 0.1 9.6e-60 202.2 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43943.1 - 4e-39 134.5 0.0 4.7e-39 134.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC43943.1 - 3.5e-07 29.5 0.1 4.6e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC43943.1 - 1.6e-06 27.2 0.0 2.3e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFC43943.1 - 4.3e-05 23.2 0.9 0.00041 20.0 0.1 2.1 1 1 1 2 2 2 1 RIO1 family ABC1 PF03109.16 EFC43943.1 - 0.00016 21.8 0.0 0.00027 21.1 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Kinase-like PF14531.6 EFC43943.1 - 0.0038 16.6 0.0 0.0063 15.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC43943.1 - 0.0045 16.9 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family SIP1 PF04938.12 EFC43944.1 - 2.2e-11 43.9 7.0 2.2e-11 43.9 7.0 2.8 1 1 0 2 2 2 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) BK_channel_a PF03493.18 EFC43944.1 - 0.39 10.9 1.6 5.1 7.4 0.0 3.1 3 0 0 3 3 3 0 Calcium-activated BK potassium channel alpha subunit DUF4604 PF15377.6 EFC43944.1 - 0.74 10.2 26.0 0.23 11.9 4.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Chromo PF00385.24 EFC43945.1 - 2.9e-07 30.3 3.8 6.7e-07 29.1 3.8 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 EFC43945.1 - 0.00079 19.3 4.3 0.0028 17.5 4.3 1.9 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain SHNi-TPR PF10516.9 EFC43946.1 - 0.00014 21.3 5.9 0.00016 21.0 0.1 3.7 4 0 0 4 4 4 1 SHNi-TPR TPR_2 PF07719.17 EFC43946.1 - 0.057 13.6 4.9 2.2 8.6 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC43946.1 - 0.061 13.6 2.2 22 5.4 0.0 3.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC43946.1 - 0.74 9.7 4.3 2.6 8.0 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Sigma70_ner PF04546.13 EFC43946.1 - 7 6.5 13.8 0.71 9.7 0.8 2.5 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF373 PF04123.13 EFC43947.1 - 2.1 7.7 12.2 4.2 6.7 12.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF373) B12D PF06522.11 EFC43947.1 - 3 7.7 5.2 0.58 10.0 0.7 2.2 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Pkinase PF00069.25 EFC43950.1 - 2.6e-18 66.4 0.1 8.6e-18 64.6 0.1 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43950.1 - 9.6e-12 44.7 0.0 3.8e-11 42.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43950.1 - 6.1e-07 28.6 0.0 8.8e-07 28.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFC43950.1 - 0.0078 15.2 0.0 0.014 14.4 0.0 1.4 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Pkinase PF00069.25 EFC43951.1 - 8.9e-27 94.1 0.0 9.8e-27 94.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43951.1 - 3.2e-14 52.9 0.0 4.5e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC43951.1 - 2.4e-08 33.2 0.0 2.9e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC43951.1 - 0.028 13.8 0.0 0.039 13.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC43951.1 - 0.096 12.6 0.0 0.19 11.6 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF4116 PF13475.6 EFC43952.1 - 2.8e-33 113.4 0.0 1e-13 50.8 0.0 3.8 3 0 0 3 3 3 3 Domain of unknown function (DUF4116) DUF4253 PF14062.6 EFC43952.1 - 0.036 14.2 0.0 0.086 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) RebB PF11747.8 EFC43952.1 - 0.045 13.9 0.3 0.085 13.0 0.3 1.4 1 0 0 1 1 1 0 Killing trait LCAT PF02450.15 EFC43953.1 - 2.3e-40 139.0 3.5 1.5e-25 90.2 0.1 2.0 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase DUF915 PF06028.11 EFC43953.1 - 1.2e-05 24.8 0.7 0.025 13.9 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF915) DUF676 PF05057.14 EFC43953.1 - 0.00018 21.1 0.0 0.00034 20.2 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 EFC43953.1 - 0.0033 17.1 0.1 0.01 15.5 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC43953.1 - 0.076 13.6 0.0 0.11 13.0 0.0 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF4441 PF14536.6 EFC43953.1 - 0.099 12.8 0.7 3.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) Esterase PF00756.20 EFC43953.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Lysine_decarbox PF03641.14 EFC43955.1 - 1.1e-16 61.1 0.0 1.8e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFC43955.1 - 8.4e-13 48.2 0.0 8.7e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 SLOG cluster4 family C9orf72-like PF15019.6 EFC43955.1 - 0.13 11.8 0.3 0.2 11.2 0.3 1.2 1 0 0 1 1 1 0 C9orf72-like protein family F-box PF00646.33 EFC43956.1 - 0.0038 17.1 0.8 0.0038 17.1 0.8 2.3 2 0 0 2 2 2 1 F-box domain DUF1839 PF08893.10 EFC43956.1 - 0.14 11.3 0.1 0.21 10.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1839) EF1G PF00647.19 EFC43957.1 - 1.3e-19 70.2 0.2 2.7e-19 69.2 0.1 1.5 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain RGS PF00615.19 EFC43958.1 - 0.00046 20.5 8.4 0.00046 20.5 8.4 3.0 2 1 0 2 2 2 1 Regulator of G protein signaling domain DUF4028 PF13220.6 EFC43958.1 - 0.0034 17.1 0.3 0.01 15.6 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4028) RGS PF00615.19 EFC43959.1 - 9.3e-05 22.7 0.7 9.3e-05 22.7 0.7 2.6 4 0 0 4 4 4 1 Regulator of G protein signaling domain DUF4263 PF14082.6 EFC43959.1 - 0.09 13.0 1.6 0.15 12.3 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4263) DUF5018 PF16410.5 EFC43960.1 - 0.011 14.4 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) PQQ_2 PF13360.6 EFC43960.1 - 0.016 14.8 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 PQQ-like domain OCRE PF17780.1 EFC43960.1 - 0.11 12.6 0.0 0.35 10.9 0.0 1.8 1 0 0 1 1 1 0 OCRE domain RICTOR_N PF14664.6 EFC43961.1 - 0.072 12.1 0.4 0.092 11.7 0.4 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term DUF4755 PF15947.5 EFC43961.1 - 0.084 12.8 0.7 1.7 8.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4755) zf-CCHC_3 PF13917.6 EFC43961.1 - 0.72 9.9 5.9 0.58 10.2 0.3 2.8 2 0 0 2 2 2 0 Zinc knuckle adh_short PF00106.25 EFC43962.1 - 1.7e-27 96.2 0.3 8.2e-26 90.7 0.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC43962.1 - 1.5e-10 41.0 0.0 2.3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC43962.1 - 7e-08 32.6 0.1 1e-07 32.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 EFC43962.1 - 0.0035 17.6 0.1 0.0071 16.6 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EFC43962.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 EFC43962.1 - 0.017 15.2 0.1 0.038 14.1 0.1 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 EFC43962.1 - 0.018 14.5 0.1 0.028 13.9 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC43962.1 - 0.018 14.9 0.0 0.022 14.6 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding DOMON PF03351.17 EFC43963.1 - 1.9e-19 70.1 0.3 4.1e-19 69.0 0.3 1.6 1 0 0 1 1 1 1 DOMON domain TrmE_N PF10396.9 EFC43964.1 - 0.024 14.9 0.0 0.053 13.8 0.0 1.5 1 0 0 1 1 1 0 GTP-binding protein TrmE N-terminus E1_DerP2_DerF2 PF02221.15 EFC43965.1 - 1.1e-17 64.8 0.1 1.2e-17 64.6 0.1 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EFC43965.1 - 3.9e-05 24.0 0.1 8.2e-05 23.0 0.1 1.6 1 1 1 2 2 2 1 ML-like domain Big_9 PF17963.1 EFC43965.1 - 0.095 13.5 1.1 0.24 12.2 0.3 1.9 2 0 0 2 2 2 0 Bacterial Ig domain Big_3_5 PF16640.5 EFC43965.1 - 0.27 11.4 3.7 2 8.7 2.3 2.2 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 3) 2OG-FeII_Oxy_3 PF13640.6 EFC43966.1 - 2.2e-08 34.9 0.1 3.2e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 EFC43966.1 - 0.01 16.1 0.0 0.014 15.7 0.0 1.4 1 1 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) PAD PF03068.15 EFC43966.1 - 0.12 11.3 0.0 0.17 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) RGS PF00615.19 EFC43967.1 - 3.8e-08 33.6 9.6 1.2e-06 28.8 4.2 3.5 3 1 0 3 3 3 1 Regulator of G protein signaling domain DUF3593 PF12159.8 EFC43967.1 - 0.043 13.8 0.7 0.043 13.8 0.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3593) RNA_pol_Rpb5_C PF01191.19 EFC43967.1 - 0.061 13.2 1.5 0.15 12.0 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Actin PF00022.19 EFC43968.1 - 7.3e-117 390.4 0.0 1.1e-115 386.5 0.0 1.9 1 1 0 1 1 1 1 Actin Fic PF02661.18 EFC43969.1 - 6.3e-16 59.1 0.0 1.6e-15 57.7 0.0 1.7 1 0 0 1 1 1 1 Fic/DOC family TMEMspv1-c74-12 PF11044.8 EFC43969.1 - 0.2 11.7 1.8 0.54 10.3 1.8 1.7 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein FRG1 PF06229.12 EFC43970.1 - 0.0017 18.1 0.2 0.25 11.1 0.0 3.0 2 1 1 3 3 3 2 FRG1-like domain Fascin PF06268.13 EFC43970.1 - 0.0041 17.3 0.5 4.4 7.6 0.0 3.2 2 2 0 3 3 3 2 Fascin domain EF-hand_6 PF13405.6 EFC43970.1 - 0.0073 16.2 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain DUF4367 PF14285.6 EFC43970.1 - 0.024 15.1 0.2 0.048 14.1 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4367) EF-hand_1 PF00036.32 EFC43970.1 - 0.031 13.8 0.0 0.075 12.6 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 EFC43970.1 - 0.16 12.5 0.0 0.28 11.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair NMT PF01233.19 EFC43971.1 - 0.015 15.2 2.1 0.024 14.5 2.1 1.5 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain MtrB PF05440.12 EFC43971.1 - 0.12 12.8 1.6 0.28 11.6 0.2 2.1 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF1664 PF07889.12 EFC43971.1 - 2.5 8.2 9.6 3.9 7.5 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 EFC43971.1 - 4.7 7.3 22.1 0.26 11.4 13.8 2.3 1 1 1 2 2 2 0 RasGAP C-terminus Nitrate_red_gam PF02665.14 EFC43973.1 - 0.067 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Esterase_phd PF10503.9 EFC43974.1 - 0.013 15.0 0.1 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Esterase PHB depolymerase GCN5L1 PF06320.13 EFC43975.1 - 0.038 14.1 1.1 0.15 12.2 0.7 2.2 2 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) RCC1_2 PF13540.6 EFC43976.1 - 2.5e-20 71.7 4.8 1.8e-06 27.6 0.2 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC43976.1 - 4.1e-19 68.9 1.5 1.1e-08 35.5 0.0 6.7 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC43979.1 - 1.6e-23 83.4 0.1 2.7e-23 82.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC43979.1 - 2.7e-11 43.3 0.0 3.7e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Phage_rep_O PF04492.13 EFC43979.1 - 0.006 17.1 0.1 0.032 14.8 0.3 2.2 2 1 0 2 2 2 1 Bacteriophage replication protein O Kdo PF06293.14 EFC43979.1 - 0.014 14.8 0.3 0.014 14.8 0.3 1.8 2 1 1 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family ATPase PF06745.13 EFC43979.1 - 0.048 13.0 0.4 0.06 12.7 0.4 1.2 1 0 0 1 1 1 0 KaiC APH PF01636.23 EFC43979.1 - 0.082 12.8 0.2 0.13 12.2 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Protamine_P2 PF00841.19 EFC43980.1 - 0.003 18.0 8.4 0.0035 17.8 8.4 1.1 1 0 0 1 1 1 1 Sperm histone P2 TcdB_N PF12918.7 EFC43980.1 - 4.1 7.8 10.4 9.2 6.6 1.1 2.5 1 1 2 3 3 3 0 TcdB toxin N-terminal helical domain Ank_2 PF12796.7 EFC43981.1 - 1.1e-19 70.8 0.1 6.6e-12 45.9 0.0 3.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC43981.1 - 5.6e-15 53.9 0.0 0.0002 21.5 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 EFC43981.1 - 1.8e-14 53.9 0.0 2.8e-05 24.6 0.0 3.4 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC43981.1 - 3.6e-10 39.9 0.0 0.00064 20.0 0.0 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC43981.1 - 6e-10 39.1 0.1 7.8e-05 22.9 0.0 4.3 5 0 0 5 5 5 2 Ankyrin repeat AnkUBD PF18418.1 EFC43981.1 - 0.093 12.9 0.0 12 6.1 0.0 2.7 3 0 0 3 3 3 0 Ankyrin ubiquitin-binding domain Peptidase_M3 PF01432.20 EFC43983.1 - 1.6e-131 439.8 0.1 2.3e-131 439.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M3 RasGEF PF00617.19 EFC43984.1 - 1.7e-42 145.6 6.5 4e-42 144.4 6.5 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFC43984.1 - 1.2e-16 60.9 0.9 1.9e-15 57.0 0.1 3.3 2 0 0 2 2 2 1 RasGEF N-terminal motif LisH PF08513.11 EFC43984.1 - 0.076 13.0 0.2 0.076 13.0 0.2 2.0 2 0 0 2 2 2 0 LisH Cupin_8 PF13621.6 EFC43986.1 - 3.1e-32 112.3 2.2 6.1e-32 111.3 2.2 1.5 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EFC43986.1 - 0.0071 16.8 1.0 0.47 10.9 0.0 2.9 3 0 0 3 3 3 1 JmjC domain, hydroxylase Wzz PF02706.15 EFC43986.1 - 0.12 12.7 0.1 0.25 11.7 0.1 1.5 1 0 0 1 1 1 0 Chain length determinant protein Phage_capsid PF05065.13 EFC43987.1 - 0.016 14.6 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Phage capsid family BUD22 PF09073.10 EFC43988.1 - 0.0057 16.1 25.3 0.0057 16.1 25.3 2.3 2 0 0 2 2 2 1 BUD22 SDA1 PF05285.12 EFC43988.1 - 7 6.0 37.5 0.51 9.7 29.4 2.3 2 0 0 2 2 2 0 SDA1 Spec3 PF15795.5 EFC43989.1 - 6.6e-13 49.0 13.4 3.1e-12 46.9 13.4 1.8 1 1 0 1 1 1 1 Ectodermal ciliogenesis protein DUF4234 PF14018.6 EFC43989.1 - 0.0098 16.0 1.2 0.0098 16.0 1.2 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4234) MMR_HSR1 PF01926.23 EFC43990.1 - 8.3e-15 54.9 0.3 1.9e-13 50.5 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC43990.1 - 1.3e-07 31.3 0.0 7.9e-07 28.7 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC43990.1 - 1.2e-06 28.5 0.3 7.7e-05 22.7 0.3 2.7 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 EFC43990.1 - 0.00012 21.7 0.2 0.0031 17.1 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain cobW PF02492.19 EFC43990.1 - 0.00068 19.3 0.4 0.037 13.6 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 EFC43990.1 - 0.0081 16.2 0.3 0.018 15.0 0.3 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 EFC43990.1 - 0.024 14.1 0.2 0.6 9.5 0.0 2.8 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC43990.1 - 0.077 12.6 0.5 2.9 7.5 0.1 2.2 2 0 0 2 2 2 0 Ras family Roc PF08477.13 EFC43990.1 - 0.13 12.4 0.1 0.98 9.7 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFC43990.1 - 0.14 12.2 1.8 7.5 6.6 0.1 3.1 3 1 0 3 3 3 0 Dynamin family Aldo_ket_red PF00248.21 EFC43991.1 - 1.4e-43 149.2 0.0 4.1e-41 141.1 0.1 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Sacchrp_dh_NADP PF03435.18 EFC43991.1 - 0.13 12.5 0.0 7.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Kelch_5 PF13854.6 EFC43994.1 - 3.4e-20 71.6 6.6 2.7e-07 30.4 0.1 6.1 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 EFC43994.1 - 5.2e-17 61.6 8.8 2.1e-07 30.8 0.1 6.0 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC43994.1 - 1.4e-15 56.5 5.3 6.3e-06 25.7 0.0 5.1 6 0 0 6 6 6 3 Kelch motif BTB PF00651.31 EFC43994.1 - 2.2e-14 53.6 5.9 1.3e-07 31.8 1.6 3.3 3 0 0 3 3 3 2 BTB/POZ domain Kelch_6 PF13964.6 EFC43994.1 - 4.7e-13 48.9 7.9 0.00048 20.3 0.2 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 EFC43994.1 - 6.3e-13 48.7 1.0 0.001 19.3 0.0 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC43994.1 - 7.4e-07 28.9 13.1 0.24 11.4 0.1 6.1 6 0 0 6 6 6 3 Kelch motif DUF2505 PF10698.9 EFC43995.1 - 0.046 13.8 0.0 0.06 13.5 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2505) F-box-like PF12937.7 EFC43996.1 - 0.00029 20.7 0.1 0.00071 19.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like Antimicrobial20 PF08256.11 EFC43996.1 - 0.043 14.3 0.9 0.16 12.5 0.9 2.1 1 0 0 1 1 1 0 Aurein-like antibiotic peptide Globin PF00042.22 EFC43996.1 - 0.091 13.3 0.0 0.28 11.7 0.0 1.8 1 0 0 1 1 1 0 Globin F-box PF00646.33 EFC43996.1 - 0.095 12.6 0.1 0.3 11.0 0.1 1.8 1 0 0 1 1 1 0 F-box domain Ephrin_rec_like PF07699.13 EFC43997.1 - 0.046 13.5 14.2 1.5 8.6 6.7 2.6 1 1 1 2 2 2 0 Putative ephrin-receptor like Methyltransf_23 PF13489.6 EFC43997.1 - 0.15 11.8 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Furin-like_2 PF15913.5 EFC43997.1 - 0.34 11.1 6.3 0.19 11.9 0.6 2.2 1 1 1 2 2 2 0 Furin-like repeat, cysteine-rich NCD3G PF07562.14 EFC43997.1 - 0.41 10.6 7.1 34 4.5 7.1 2.3 1 1 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR TNFR_c6 PF00020.18 EFC43997.1 - 0.43 11.0 8.5 11 6.5 8.5 2.4 1 1 0 1 1 1 0 TNFR/NGFR cysteine-rich region gpW PF02831.15 EFC43998.1 - 0.12 12.2 0.0 9.9 6.1 0.0 2.8 3 0 0 3 3 3 0 gpW AMP-binding PF00501.28 EFC44000.1 - 5e-50 170.3 0.0 9.6e-36 123.3 0.0 2.4 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 EFC44000.1 - 0.00017 22.5 0.2 0.00093 20.1 0.2 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Meiotic_rec114 PF03525.14 EFC44000.1 - 0.089 11.7 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Meiotic recombination protein rec114 Pkinase PF00069.25 EFC44001.1 - 3.6e-60 203.6 0.0 4.6e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44001.1 - 1.1e-29 103.5 0.1 1.7e-29 102.9 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC44001.1 - 0.00074 18.6 0.6 0.0013 17.7 0.6 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Ank_2 PF12796.7 EFC44002.1 - 8.7e-08 32.7 3.2 0.0015 19.1 0.2 4.6 4 1 0 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC44002.1 - 0.00034 21.1 0.5 1.6 9.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC44002.1 - 0.033 14.5 0.1 1.2 9.6 0.0 3.7 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC44002.1 - 0.051 14.1 1.6 51 4.9 0.0 5.5 5 0 0 5 5 5 0 Ankyrin repeat Mpp10 PF04006.12 EFC44002.1 - 0.17 10.3 30.8 0.39 9.1 19.2 2.1 2 0 0 2 2 2 0 Mpp10 protein IMS PF00817.20 EFC44003.1 - 7.7e-35 120.1 0.0 1.4e-34 119.3 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 EFC44003.1 - 5.6e-10 39.9 0.0 1.3e-09 38.8 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Hist_deacetyl PF00850.19 EFC44003.1 - 0.037 13.5 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Histone deacetylase domain Ribosomal_S6e PF01092.19 EFC44004.1 - 7.1e-40 135.9 0.2 7.1e-40 135.9 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein S6e F-box PF00646.33 EFC44006.1 - 0.011 15.6 0.7 0.49 10.3 0.0 2.7 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EFC44006.1 - 0.027 14.4 0.0 0.088 12.7 0.0 1.9 1 0 0 1 1 1 0 F-box-like F-box_4 PF15966.5 EFC44006.1 - 0.041 13.8 0.2 0.49 10.3 0.0 2.9 2 1 0 2 2 2 0 F-box KxDL PF10241.9 EFC44006.1 - 0.13 12.6 1.9 2.2 8.6 0.1 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein IFT20 PF14931.6 EFC44006.1 - 0.33 11.1 3.9 1.2 9.3 0.3 2.5 2 1 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Nas2_N PF18265.1 EFC44007.1 - 2e-26 91.7 0.3 2.6e-26 91.3 0.3 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain Kazal_1 PF00050.21 EFC44008.1 - 1.3e-05 25.1 4.6 4.1e-05 23.5 4.6 1.9 1 0 0 1 1 1 1 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EFC44008.1 - 9e-05 22.5 10.5 9.3e-05 22.5 8.9 2.0 2 0 0 2 2 2 1 Kazal-type serine protease inhibitor domain HBM PF16591.5 EFC44008.1 - 0.96 8.8 10.6 0.39 10.1 2.5 2.3 1 1 0 2 2 2 0 Helical bimodular sensor domain bVLRF1 PF18826.1 EFC44008.1 - 2.8 7.8 6.9 20 5.1 0.6 3.1 1 1 2 3 3 3 0 bacteroidetes VLRF1 release factor SpoIIE PF07228.12 EFC44009.1 - 3.5e-10 40.1 0.0 6.2e-10 39.3 0.0 1.4 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 EFC44009.1 - 1e-06 28.6 0.0 5.4e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Protein phosphatase 2C ABC_tran PF00005.27 EFC44010.1 - 2.3e-24 86.5 0.0 1.1e-23 84.3 0.0 2.2 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFC44010.1 - 5.1e-05 22.9 0.1 0.00013 21.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 EFC44010.1 - 7.8e-05 22.2 1.7 0.041 13.3 0.2 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_14 PF13173.6 EFC44010.1 - 0.0012 18.9 2.8 0.014 15.4 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 EFC44010.1 - 0.052 13.8 0.1 1.1 9.5 0.0 2.9 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EFC44010.1 - 0.092 12.8 0.2 0.51 10.4 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase PDZ_1 PF12812.7 EFC44010.1 - 0.17 11.9 0.2 23 5.1 0.0 3.0 2 1 1 3 3 3 0 PDZ-like domain NTP_transf_2 PF01909.23 EFC44012.1 - 8e-08 32.5 3.2 1.5e-07 31.6 0.0 2.7 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 EFC44012.1 - 1.8e-07 31.2 0.1 5.3e-07 29.8 0.1 1.9 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 EFC44012.1 - 0.0023 18.0 0.3 0.0099 15.9 0.0 2.3 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase DUF745 PF05335.13 EFC44012.1 - 0.064 13.0 3.5 0.12 12.1 3.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Dot_icm_IcmQ PF09475.10 EFC44012.1 - 0.74 9.3 9.4 0.096 12.2 4.0 2.2 2 1 0 2 2 2 0 Dot/Icm secretion system protein (dot_icm_IcmQ) MID_MedPIWI PF18296.1 EFC44013.1 - 8.1e-10 38.9 2.5 4.9e-07 29.8 0.0 4.9 2 2 1 3 3 3 2 MID domain of medPIWI Med13_C PF06333.12 EFC44013.1 - 1.4e-05 24.6 0.1 1.4e-05 24.6 0.1 4.5 2 2 2 4 4 4 2 Mediator complex subunit 13 C-terminal domain Neur_chan_memb PF02932.16 EFC44013.1 - 0.0067 16.5 2.2 0.0067 16.5 2.2 2.7 2 1 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DUF4501 PF14946.6 EFC44013.1 - 0.012 15.7 0.6 5.9 6.9 0.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4501) DUF4495 PF14906.6 EFC44013.1 - 0.021 13.9 0.5 2.3 7.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4495) SNARE PF05739.19 EFC44014.1 - 0.004 17.1 3.9 0.012 15.6 3.9 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin-6_N PF09177.11 EFC44014.1 - 0.0078 16.7 6.3 0.018 15.6 0.5 2.4 1 1 0 2 2 2 1 Syntaxin 6, N-terminal KxDL PF10241.9 EFC44014.1 - 0.056 13.7 6.0 0.16 12.3 1.5 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein Amnionless PF14828.6 EFC44014.1 - 0.13 11.0 0.3 0.23 10.2 0.0 1.6 2 0 0 2 2 2 0 Amnionless Sec20 PF03908.13 EFC44014.1 - 0.16 11.9 3.7 0.25 11.3 0.9 2.5 2 2 0 2 2 2 0 Sec20 DUF2367 PF10164.9 EFC44014.1 - 0.23 12.0 0.3 0.4 11.2 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) ASFV_J13L PF05568.11 EFC44014.1 - 1.2 8.8 3.3 2 8.1 3.3 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein XhlA PF10779.9 EFC44014.1 - 1.7 8.9 9.8 0.055 13.7 2.9 2.1 3 0 0 3 3 3 0 Haemolysin XhlA DUF2207 PF09972.9 EFC44014.1 - 2.5 6.8 9.4 0.077 11.7 0.9 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) LRR19-TM PF15176.6 EFC44014.1 - 7.9 6.5 7.8 3.5 7.7 4.0 2.2 1 1 1 2 2 2 0 Leucine-rich repeat family 19 TM domain Occludin_ELL PF07303.13 EFC44015.1 - 9.9e-16 58.3 9.6 9.9e-16 58.3 9.6 1.9 2 0 0 2 2 2 1 Occludin homology domain PRANC PF09372.10 EFC44015.1 - 8.8e-05 22.8 0.9 0.00019 21.7 0.7 1.7 1 1 0 1 1 1 1 PRANC domain FapA PF03961.13 EFC44015.1 - 0.043 12.4 3.4 0.07 11.7 3.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Nop PF01798.18 EFC44015.1 - 0.42 10.0 8.1 0.041 13.3 2.7 1.9 2 0 0 2 2 2 0 snoRNA binding domain, fibrillarin YxiJ PF14176.6 EFC44015.1 - 0.53 10.8 5.5 7 7.2 2.2 2.4 1 1 0 2 2 2 0 YxiJ-like protein DUF4375 PF14300.6 EFC44015.1 - 3.8 7.8 7.9 33 4.8 7.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4375) Peptidase_C2 PF00648.21 EFC44016.1 - 2e-40 138.7 0.1 2e-40 138.7 0.1 1.5 2 0 0 2 2 2 1 Calpain family cysteine protease Swi3 PF07962.12 EFC44016.1 - 0.028 14.4 0.1 0.097 12.7 0.1 1.9 1 0 0 1 1 1 0 Replication Fork Protection Component Swi3 MCC-bdg_PDZ PF10506.9 EFC44016.1 - 0.17 12.0 0.8 0.43 10.6 0.8 1.7 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF1731 PF08338.11 EFC44017.1 - 1.5e-13 50.3 0.0 3.1e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1731) Epimerase PF01370.21 EFC44017.1 - 1.3e-08 34.6 0.5 5.6e-07 29.3 0.5 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFC44017.1 - 0.028 13.6 0.3 0.12 11.5 0.2 2.0 2 0 0 2 2 2 0 Male sterility protein DUF4467 PF14729.6 EFC44017.1 - 0.03 14.7 0.3 0.03 14.7 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) 3Beta_HSD PF01073.19 EFC44017.1 - 0.044 12.8 3.9 1.2 8.0 0.6 2.3 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family BTB PF00651.31 EFC44018.1 - 0.029 14.6 0.1 0.084 13.1 0.1 1.8 1 1 0 1 1 1 0 BTB/POZ domain NADH_dhqG_C PF09326.11 EFC44018.1 - 0.04 14.6 0.1 0.096 13.4 0.1 1.7 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit G, C-terminal Importin_rep_4 PF18808.1 EFC44019.1 - 1.8e-18 66.6 2.1 1.6e-17 63.6 0.1 3.5 4 1 0 4 4 2 1 Importin repeat Vac14_Fab1_bd PF12755.7 EFC44019.1 - 1.1e-17 64.4 9.6 0.00026 21.5 0.1 8.0 6 2 2 8 8 8 4 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 EFC44019.1 - 7.9e-16 58.2 0.1 0.00019 21.8 0.0 7.5 4 2 5 9 9 9 5 HEAT repeats HEAT_EZ PF13513.6 EFC44019.1 - 1.9e-14 53.8 14.7 0.0035 17.8 0.0 10.2 11 1 1 12 12 8 4 HEAT-like repeat HEAT PF02985.22 EFC44019.1 - 2.4e-13 49.1 13.5 0.15 12.4 0.0 10.0 12 0 0 12 12 11 4 HEAT repeat Adaptin_N PF01602.20 EFC44019.1 - 5e-11 41.9 7.2 0.00044 18.9 0.0 4.8 3 2 1 4 4 4 2 Adaptin N terminal region Cnd1 PF12717.7 EFC44019.1 - 2.2e-09 37.6 7.9 0.00036 20.6 0.1 5.4 4 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 EFC44019.1 - 8.3e-06 25.6 8.6 5e-05 23.1 0.2 4.8 4 0 0 4 4 4 1 Importin-beta N-terminal domain RTP1_C1 PF10363.9 EFC44019.1 - 3.8e-05 23.8 6.9 1.3 9.2 0.0 6.2 6 0 0 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 UME PF08064.13 EFC44019.1 - 0.0027 17.6 5.3 2.1 8.3 0.0 5.9 6 1 1 7 7 7 1 UME (NUC010) domain DNA_alkylation PF08713.11 EFC44019.1 - 0.0064 16.2 0.0 0.17 11.6 0.0 3.2 4 0 0 4 4 4 1 DNA alkylation repair enzyme V-ATPase_H_N PF03224.14 EFC44019.1 - 0.012 14.9 14.7 0.12 11.6 0.5 5.1 3 2 2 5 5 5 0 V-ATPase subunit H Importin_rep_6 PF18829.1 EFC44019.1 - 0.013 15.6 0.9 0.013 15.6 0.9 3.4 3 0 0 3 3 2 0 Importin repeat 6 Phage_lysozyme PF00959.19 EFC44019.1 - 0.017 15.5 0.0 0.063 13.7 0.0 1.9 1 0 0 1 1 1 0 Phage lysozyme Arm PF00514.23 EFC44019.1 - 0.034 14.2 7.3 13 6.0 0.0 6.5 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat MOR2-PAG1_C PF14225.6 EFC44019.1 - 0.047 13.6 5.7 0.39 10.5 0.1 3.8 4 1 0 4 4 3 0 Cell morphogenesis C-terminal RIX1 PF08167.12 EFC44019.1 - 0.13 12.0 0.0 0.13 12.0 0.0 4.8 6 1 0 6 6 6 0 rRNA processing/ribosome biogenesis Urb2 PF10441.9 EFC44019.1 - 0.13 12.1 10.2 0.69 9.8 0.3 4.2 5 1 0 5 5 5 0 Urb2/Npa2 family XPC-binding PF09280.11 EFC44019.1 - 0.21 11.3 7.1 2.3 8.0 7.1 2.9 1 0 0 1 1 1 0 XPC-binding domain Hydrolase_6 PF13344.6 EFC44020.1 - 3.9e-20 71.9 0.1 7.2e-20 71.0 0.1 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFC44020.1 - 4.1e-14 52.4 0.0 1.2e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 EFC44020.1 - 6.5e-07 29.6 0.3 0.0077 16.3 0.2 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 EFC44020.1 - 5.8e-05 22.8 0.4 0.00049 19.7 0.1 2.2 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Hydrolase PF00702.26 EFC44020.1 - 0.00011 22.6 0.0 0.017 15.4 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase DUF2608 PF11019.8 EFC44020.1 - 0.048 13.1 0.1 0.081 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) Complex1_51K PF01512.17 EFC44021.1 - 3.9e-46 156.7 0.0 6.6e-46 155.9 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 EFC44021.1 - 1.6e-31 108.2 0.1 3.8e-31 107.0 0.1 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 EFC44021.1 - 7.5e-07 28.9 0.0 1.9e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 SLBB domain GHMP_kinases_C PF08544.13 EFC44021.1 - 0.15 12.4 0.0 8.9 6.8 0.0 2.6 2 0 0 2 2 2 0 GHMP kinases C terminal TUG-UBL1 PF11470.8 EFC44022.1 - 2.8e-14 53.1 0.3 8.1e-14 51.6 0.1 2.0 2 0 0 2 2 2 1 TUG ubiquitin-like domain F-box PF00646.33 EFC44022.1 - 1.6e-08 34.2 1.2 4e-08 32.9 1.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC44022.1 - 1.8e-06 27.7 1.6 3.4e-06 26.8 1.6 1.4 1 0 0 1 1 1 1 F-box-like Rad60-SLD PF11976.8 EFC44022.1 - 0.02 14.7 0.1 0.46 10.3 0.0 2.9 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like UBX PF00789.20 EFC44022.1 - 0.02 15.1 0.0 0.16 12.2 0.0 2.6 2 1 0 2 2 2 0 UBX domain Cobl PF09469.10 EFC44022.1 - 0.023 15.0 0.0 0.19 12.0 0.0 2.5 2 0 0 2 2 2 0 Cordon-bleu ubiquitin-like domain THF_DHG_CYH_C PF02882.19 EFC44023.1 - 3.4e-58 195.5 0.3 6.6e-58 194.6 0.3 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 EFC44023.1 - 7.8e-36 122.9 2.8 1.2e-35 122.2 2.8 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 EFC44023.1 - 0.002 17.1 0.1 0.0033 16.4 0.1 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family ClpS PF02617.17 EFC44023.1 - 0.26 11.1 1.6 3.5 7.5 0.1 2.5 2 0 0 2 2 2 0 ATP-dependent Clp protease adaptor protein ClpS Ligase_CoA PF00549.19 EFC44023.1 - 0.41 10.5 2.6 2.3 8.0 0.1 2.8 2 1 0 3 3 3 0 CoA-ligase CBS PF00571.28 EFC44027.1 - 2.8e-34 117.3 4.9 2.6e-09 37.4 0.1 4.2 4 0 0 4 4 4 4 CBS domain AAA PF00004.29 EFC44029.1 - 7.3e-51 172.1 0.1 4.8e-40 137.0 0.0 3.3 4 0 0 4 4 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC44029.1 - 4.6e-08 32.7 0.2 2.5e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain Bromodomain PF00439.25 EFC44029.1 - 1.2e-06 28.4 1.2 5.6e-06 26.3 0.9 2.3 2 0 0 2 2 2 1 Bromodomain AAA_16 PF13191.6 EFC44029.1 - 3.7e-06 27.4 1.2 0.0055 17.1 0.2 4.7 2 2 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EFC44029.1 - 5.9e-05 23.3 0.0 0.00033 20.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 EFC44029.1 - 0.00021 21.3 0.0 0.0057 16.7 0.0 2.9 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC44029.1 - 0.0019 18.5 0.5 0.26 11.5 0.4 4.1 3 1 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFC44029.1 - 0.0057 17.0 0.0 0.04 14.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EFC44029.1 - 0.0071 16.9 0.0 0.076 13.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFC44029.1 - 0.013 15.3 0.0 0.038 13.7 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein PRANC PF09372.10 EFC44029.1 - 0.013 15.8 3.5 5 7.5 1.4 2.7 2 0 0 2 2 2 0 PRANC domain TFIIF_alpha PF05793.12 EFC44029.1 - 0.025 13.2 41.1 0.061 11.9 15.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NACHT PF05729.12 EFC44029.1 - 0.026 14.5 0.0 0.12 12.3 0.0 2.3 3 0 0 3 3 2 0 NACHT domain RuvB_N PF05496.12 EFC44029.1 - 0.029 14.1 0.0 0.082 12.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 EFC44029.1 - 0.048 13.0 0.2 0.17 11.3 0.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFC44029.1 - 0.048 13.8 0.0 0.17 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC44029.1 - 0.048 13.9 0.1 0.18 12.1 0.1 2.0 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 EFC44029.1 - 0.074 12.7 0.0 12 5.6 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Nup88 PF10168.9 EFC44030.1 - 4.6e-05 21.5 1.1 9.2e-05 20.5 0.2 1.9 3 0 0 3 3 3 1 Nuclear pore component RTA1 PF04479.13 EFC44030.1 - 0.26 10.8 3.4 0.52 9.9 3.4 1.4 1 0 0 1 1 1 0 RTA1 like protein EGF_2 PF07974.13 EFC44031.1 - 4.7e-05 23.7 8.6 4.7e-05 23.7 8.6 3.3 4 0 0 4 4 4 1 EGF-like domain UPF0564 PF10595.9 EFC44032.1 - 8.9e-34 117.1 44.8 8.9e-34 117.1 44.8 3.5 3 1 0 3 3 3 1 Uncharacterised protein family UPF0564 Exo84_C PF16528.5 EFC44032.1 - 2.6e-17 63.3 8.7 2.6e-17 63.3 8.7 2.3 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EFC44032.1 - 7.8e-07 29.1 0.3 7.8e-07 29.1 0.3 3.5 3 0 0 3 3 3 1 Vps51/Vps67 FCH PF00611.23 EFC44032.1 - 0.037 14.3 2.1 1.1 9.6 0.3 4.0 4 0 0 4 4 4 0 Fes/CIP4, and EFC/F-BAR homology domain DeoC PF01791.9 EFC44033.1 - 1.5e-21 77.1 5.1 1.8e-21 76.9 5.1 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase DUF943 PF06092.12 EFC44033.1 - 0.055 13.1 0.3 0.095 12.4 0.3 1.3 1 0 0 1 1 1 0 Enterobacterial putative membrane protein (DUF943) PapC_N PF13954.6 EFC44033.1 - 0.14 12.1 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 PapC N-terminal domain BBS2_Mid PF14783.6 EFC44034.1 - 5.8e-10 39.2 0.4 3.4e-09 36.7 0.1 2.5 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.6 EFC44034.1 - 0.00063 20.3 1.2 0.027 15.0 0.1 3.2 2 1 1 3 3 3 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFC44034.1 - 0.023 14.8 0.1 0.064 13.4 0.1 1.6 1 0 0 1 1 1 0 FG-GAP repeat Spc24 PF08286.11 EFC44034.1 - 1.6 9.0 6.8 1.5 9.1 0.5 2.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF3395 PF11875.8 EFC44035.1 - 4.1e-36 124.2 0.1 4.1e-36 124.2 0.1 2.6 4 0 0 4 4 4 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 EFC44035.1 - 7.8e-17 61.2 8.9 8.7e-17 61.0 5.0 2.9 2 1 0 2 2 2 1 DnaJ domain SLT_L PF14718.6 EFC44035.1 - 0.046 13.8 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Soluble lytic murein transglycosylase L domain GNAT_acetyltr_2 PF13718.6 EFC44035.1 - 0.17 11.3 0.0 0.17 11.3 0.0 2.5 3 1 0 3 3 3 0 GNAT acetyltransferase 2 SYCE1 PF15233.6 EFC44035.1 - 3.8 7.5 16.3 0.056 13.5 7.1 2.3 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 Transglut_core PF01841.19 EFC44036.1 - 0.0081 16.6 0.0 0.033 14.6 0.0 2.1 1 1 0 1 1 1 1 Transglutaminase-like superfamily eIF-5a PF01287.20 EFC44036.1 - 0.33 11.1 2.9 6.2 7.0 0.0 3.4 4 0 0 4 4 4 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold MFS_1 PF07690.16 EFC44037.1 - 8.6e-43 146.6 38.3 1.5e-30 106.3 18.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC44037.1 - 7.8e-40 137.1 30.8 2.7e-39 135.3 30.8 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2964 PF11177.8 EFC44037.1 - 0.083 13.1 0.3 0.083 13.1 0.3 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2964) MFS_1_like PF12832.7 EFC44037.1 - 0.18 10.7 28.2 2.4 6.9 28.2 2.4 1 1 0 1 1 1 0 MFS_1 like family Beta_helix PF13229.6 EFC44038.1 - 1.7e-17 63.7 50.1 2e-15 57.0 27.4 3.6 1 1 2 3 3 3 2 Right handed beta helix region NosD PF05048.13 EFC44038.1 - 2.2e-13 50.1 64.2 1.2e-12 47.7 38.2 3.2 1 1 2 3 3 3 2 Periplasmic copper-binding protein (NosD) Actin PF00022.19 EFC44039.1 - 1.5e-100 336.7 0.3 6.2e-74 249.0 0.0 2.8 2 1 0 2 2 2 2 Actin Pkinase PF00069.25 EFC44040.1 - 7.3e-30 104.2 1.1 1.2e-29 103.5 1.1 1.4 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC44040.1 - 1.7e-26 90.9 0.0 7.8e-07 28.8 0.0 5.7 5 0 0 5 5 5 4 NHL repeat EGF_2 PF07974.13 EFC44040.1 - 2.7e-25 88.4 228.3 0.00038 20.8 12.2 13.5 13 0 0 13 13 13 11 EGF-like domain Pkinase_Tyr PF07714.17 EFC44040.1 - 9e-16 57.9 0.1 1.7e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TMEM154 PF15102.6 EFC44040.1 - 0.005 16.8 0.6 0.015 15.2 0.6 1.8 1 0 0 1 1 1 1 TMEM154 protein family DUF4690 PF15756.5 EFC44040.1 - 0.015 15.9 1.1 0.054 14.1 1.1 1.9 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DUF5385 PF17359.2 EFC44040.1 - 0.015 14.8 1.3 0.025 14.1 1.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) ASFV_J13L PF05568.11 EFC44040.1 - 0.023 14.5 1.2 0.047 13.4 1.2 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein Dynactin_p22 PF07426.11 EFC44040.1 - 0.046 13.6 0.3 6.6 6.6 0.0 2.7 2 0 0 2 2 2 0 Dynactin subunit p22 DUF3377 PF11857.8 EFC44040.1 - 0.15 12.0 0.8 0.43 10.5 0.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Syndecan PF01034.20 EFC44040.1 - 0.85 9.6 4.3 2 8.4 4.3 1.5 1 0 0 1 1 1 0 Syndecan domain DUF4328 PF14219.6 EFC44040.1 - 0.93 9.0 2.1 2.1 7.8 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4328) SKG6 PF08693.10 EFC44040.1 - 4.5 6.8 14.6 14 5.1 14.6 1.9 1 1 0 1 1 1 0 Transmembrane alpha-helix domain Renin_r PF07850.14 EFC44041.1 - 1.1 9.9 4.4 6.6 7.4 0.1 2.3 2 1 0 2 2 2 0 Renin receptor-like protein DHHC PF01529.20 EFC44041.1 - 7.9 6.6 9.5 3.9 7.6 4.6 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase Glyco_hydro_38N PF01074.22 EFC44042.1 - 2e-47 161.9 2.5 3.5e-47 161.2 2.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 EFC44042.1 - 2.3e-13 50.1 0.0 6.5e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 EFC44042.1 - 1.3e-10 41.7 0.3 2.3e-10 40.9 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain MSV199 PF10553.9 EFC44042.1 - 0.034 14.4 0.3 0.16 12.2 0.3 2.2 1 0 0 1 1 1 0 MSV199 domain ZapB PF06005.12 EFC44045.1 - 1.2e-05 25.6 12.0 0.043 14.2 1.5 3.5 2 2 1 3 3 3 2 Cell division protein ZapB Lebercilin PF15619.6 EFC44045.1 - 1.3e-05 25.0 12.5 7.4e-05 22.5 12.5 2.0 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease HALZ PF02183.18 EFC44045.1 - 4.5e-05 23.6 2.4 0.0017 18.6 0.7 3.2 2 0 0 2 2 2 1 Homeobox associated leucine zipper BLOC1_2 PF10046.9 EFC44045.1 - 0.00021 21.5 17.7 0.0098 16.2 4.7 3.6 1 1 2 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Baculo_PEP_C PF04513.12 EFC44045.1 - 0.00021 21.3 22.2 0.056 13.5 6.2 3.0 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus bZIP_1 PF00170.21 EFC44045.1 - 0.0003 20.8 0.5 0.0003 20.8 0.5 3.3 2 1 1 3 3 2 1 bZIP transcription factor TMF_TATA_bd PF12325.8 EFC44045.1 - 0.0044 17.2 2.6 0.0044 17.2 2.6 2.6 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding Filament PF00038.21 EFC44045.1 - 0.0047 16.6 12.3 0.24 11.0 12.2 2.2 1 1 1 2 2 2 2 Intermediate filament protein HAP1_N PF04849.13 EFC44045.1 - 0.0055 16.0 9.6 0.0086 15.3 9.6 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region YabA PF06156.13 EFC44045.1 - 0.0083 16.7 15.6 0.049 14.3 2.0 3.9 2 1 2 4 4 4 1 Initiation control protein YabA JIP_LZII PF16471.5 EFC44045.1 - 0.0097 16.1 8.3 0.78 10.0 1.5 3.7 2 1 1 3 3 3 1 JNK-interacting protein leucine zipper II Sec34 PF04136.15 EFC44045.1 - 0.011 15.6 11.1 0.045 13.6 3.2 2.6 2 0 0 2 2 2 0 Sec34-like family MbeD_MobD PF04899.12 EFC44045.1 - 0.018 15.2 1.4 5.6 7.2 0.0 3.3 3 1 0 3 3 2 0 MbeD/MobD like TolA_bind_tri PF16331.5 EFC44045.1 - 0.019 15.0 4.2 0.28 11.3 0.0 2.8 2 1 1 3 3 3 0 TolA binding protein trimerisation Jnk-SapK_ap_N PF09744.9 EFC44045.1 - 0.02 15.1 12.1 0.31 11.3 3.8 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 HOOK PF05622.12 EFC44045.1 - 0.022 12.9 13.2 0.065 11.4 13.1 1.7 1 1 1 2 2 2 0 HOOK protein COMMD1_N PF17221.3 EFC44045.1 - 0.022 15.0 2.7 0.054 13.8 0.8 2.5 1 1 1 2 2 2 0 COMMD1 N-terminal domain Fez1 PF06818.15 EFC44045.1 - 0.025 15.0 1.4 0.025 15.0 1.4 2.3 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 EFC44045.1 - 0.029 13.2 14.7 0.16 10.8 5.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Spectrin PF00435.21 EFC44045.1 - 0.031 14.8 7.3 2.7 8.5 0.2 3.0 3 0 0 3 3 2 0 Spectrin repeat IFT57 PF10498.9 EFC44045.1 - 0.033 13.2 18.6 0.038 13.0 7.8 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Occludin_ELL PF07303.13 EFC44045.1 - 0.035 14.8 6.6 1 10.1 0.3 3.2 1 1 2 3 3 3 0 Occludin homology domain Seryl_tRNA_N PF02403.22 EFC44045.1 - 0.046 14.0 10.1 0.36 11.1 1.2 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain H-kinase_dim PF02895.14 EFC44045.1 - 0.046 14.1 4.0 2 8.9 1.1 3.2 2 1 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain GIT_CC PF16559.5 EFC44045.1 - 0.055 13.3 7.0 0.77 9.7 0.1 3.5 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor CENP-H PF05837.12 EFC44045.1 - 0.08 13.4 14.8 0.53 10.7 2.4 3.2 1 1 2 3 3 3 0 Centromere protein H (CENP-H) Prefoldin_2 PF01920.20 EFC44045.1 - 0.084 12.8 13.6 0.25 11.3 1.5 3.5 2 1 0 3 3 3 0 Prefoldin subunit DivIVA PF05103.13 EFC44045.1 - 0.097 12.8 9.9 3.8 7.6 0.1 3.4 1 1 0 2 2 2 0 DivIVA protein Spc24 PF08286.11 EFC44045.1 - 0.11 12.7 15.5 1.1 9.6 4.8 3.6 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Atg14 PF10186.9 EFC44045.1 - 0.11 11.5 12.3 0.27 10.3 12.3 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GAS PF13851.6 EFC44045.1 - 0.13 11.6 13.5 0.65 9.3 13.5 2.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 EFC44045.1 - 0.14 11.9 10.3 0.092 12.5 1.4 3.1 1 1 1 3 3 3 0 Septum formation initiator DUF2730 PF10805.8 EFC44045.1 - 0.18 11.9 9.1 2.2 8.4 1.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) TPR_MLP1_2 PF07926.12 EFC44045.1 - 0.2 11.7 11.7 1.2 9.3 1.3 2.6 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 EFC44045.1 - 0.25 11.4 11.6 2.6 8.1 0.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) bZIP_2 PF07716.15 EFC44045.1 - 0.25 11.4 5.7 0.094 12.8 0.6 3.0 2 1 0 2 2 2 0 Basic region leucine zipper FlaC_arch PF05377.11 EFC44045.1 - 0.28 11.6 19.9 5.8 7.4 1.3 5.3 1 1 4 5 5 5 0 Flagella accessory protein C (FlaC) Cnn_1N PF07989.11 EFC44045.1 - 0.48 10.6 16.1 6.5 7.0 7.5 3.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Nup54 PF13874.6 EFC44045.1 - 0.54 10.4 7.6 8.2 6.5 7.6 2.3 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 SlyX PF04102.12 EFC44045.1 - 0.64 10.7 6.0 12 6.6 0.6 3.7 3 1 1 4 4 3 0 SlyX DUF3450 PF11932.8 EFC44045.1 - 0.66 9.2 11.5 0.88 8.8 1.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CLZ PF16526.5 EFC44045.1 - 0.74 10.2 9.0 0.71 10.3 1.1 3.7 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FAM76 PF16046.5 EFC44045.1 - 0.99 8.7 13.7 2.2 7.5 13.5 1.7 1 1 0 1 1 1 0 FAM76 protein DUF4763 PF15960.5 EFC44045.1 - 1.1 8.5 8.9 5.7 6.2 9.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) Nnf1 PF03980.14 EFC44045.1 - 1.4 9.4 7.1 1.1 9.7 0.3 2.8 2 1 0 2 2 2 0 Nnf1 Cep57_CLD_2 PF14197.6 EFC44045.1 - 1.5 9.0 7.8 4.7 7.4 0.5 3.0 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF4200 PF13863.6 EFC44045.1 - 1.6 9.2 10.1 14 6.1 0.5 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) ApoO PF09769.9 EFC44045.1 - 1.6 8.7 6.1 2.4 8.1 1.0 2.9 3 0 0 3 3 2 0 Apolipoprotein O LPP PF04728.13 EFC44045.1 - 1.8 9.0 9.0 5 7.6 0.7 4.4 3 2 0 3 3 3 0 Lipoprotein leucine-zipper Mod_r PF07200.13 EFC44045.1 - 1.9 8.6 14.4 1.8e+02 2.2 14.0 2.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein NPV_P10 PF05531.12 EFC44045.1 - 1.9 9.0 18.3 44 4.6 0.5 4.1 1 1 1 2 2 1 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 EFC44045.1 - 2 9.0 10.9 18 5.9 1.3 2.6 1 1 2 3 3 3 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 EFC44045.1 - 2.1 8.7 5.7 2.5 8.4 1.7 2.9 1 1 1 3 3 3 0 ABC transporter C-terminal domain UPF0242 PF06785.11 EFC44045.1 - 2.5 8.2 15.9 35 4.4 15.8 2.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CC2-LZ PF16516.5 EFC44045.1 - 2.7 8.4 10.7 3.9 7.9 4.7 3.2 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CENP-F_leu_zip PF10473.9 EFC44045.1 - 3.5 7.6 14.6 15 5.6 7.6 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 COG2 PF06148.11 EFC44045.1 - 4.2 7.4 8.8 0.83 9.7 0.7 2.6 1 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ATG16 PF08614.11 EFC44045.1 - 6.3 7.0 19.4 0.3 11.3 12.5 2.4 2 1 0 2 2 1 0 Autophagy protein 16 (ATG16) TACC_C PF05010.14 EFC44045.1 - 6.4 6.5 14.5 5.9 6.6 4.5 2.6 2 1 1 3 3 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DHR10 PF18595.1 EFC44045.1 - 6.6 6.8 10.2 2.1 8.5 3.1 2.5 1 1 0 2 2 2 0 Designed helical repeat protein 10 domain Myb_DNA-binding PF00249.31 EFC44047.1 - 8e-13 48.4 0.0 1.8e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC44047.1 - 0.00017 21.8 0.6 0.00017 21.8 0.6 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC44047.1 - 0.011 15.6 0.2 0.011 15.6 0.2 2.6 3 0 0 3 3 3 0 Myb DNA-binding like Methyltransf_31 PF13847.6 EFC44048.1 - 8.8e-24 84.0 0.0 1.3e-23 83.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC44048.1 - 7.7e-11 42.6 0.0 1.6e-10 41.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC44048.1 - 5e-10 40.0 0.0 1.1e-09 38.9 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC44048.1 - 5.5e-09 36.5 0.0 9.2e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC44048.1 - 8.9e-09 35.4 0.0 9.2e-08 32.1 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC44048.1 - 2.4e-07 30.3 0.0 3.5e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFC44048.1 - 3.8e-06 27.0 0.0 5.7e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC44048.1 - 8.4e-05 22.2 0.0 0.00038 20.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Pox_MCEL PF03291.16 EFC44048.1 - 0.00014 21.1 0.1 0.00025 20.3 0.1 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_18 PF12847.7 EFC44048.1 - 0.00059 19.8 0.0 0.00098 19.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 EFC44048.1 - 0.0026 17.3 0.0 0.023 14.2 0.0 2.0 2 0 0 2 2 2 1 MraW methylase family AdoMet_MTase PF07757.13 EFC44048.1 - 0.016 15.5 0.0 0.039 14.3 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase CSF-1 PF05337.11 EFC44048.1 - 0.042 14.0 0.1 0.13 12.4 0.0 1.8 2 0 0 2 2 2 0 Macrophage colony stimulating factor-1 (CSF-1) ATP-synt_D PF01813.17 EFC44049.1 - 1.1e-50 172.2 5.5 1.3e-50 172.0 5.5 1.0 1 0 0 1 1 1 1 ATP synthase subunit D MatP_C PF17414.2 EFC44049.1 - 0.053 13.7 1.1 13 6.1 0.1 3.0 1 1 1 2 2 2 0 MatP C-terminal ribbon-helix-helix domain Snapin_Pallidin PF14712.6 EFC44049.1 - 0.24 11.8 5.4 25 5.4 0.0 3.5 2 1 2 4 4 4 0 Snapin/Pallidin DUF4116 PF13475.6 EFC44050.1 - 1.9e-26 91.5 2.9 8.1e-06 25.5 0.0 5.6 2 1 3 5 5 5 5 Domain of unknown function (DUF4116) LCAT PF02450.15 EFC44051.1 - 9.1e-33 114.0 1.3 1e-30 107.2 1.3 2.1 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 EFC44051.1 - 0.017 15.7 0.0 0.06 13.9 0.0 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 EFC44051.1 - 0.023 14.5 0.1 0.091 12.6 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) DUF676 PF05057.14 EFC44051.1 - 0.085 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) CagS PF16707.5 EFC44051.1 - 0.11 12.4 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Cag pathogenicity island protein S of Helicobacter pylori Tim17 PF02466.19 EFC44052.1 - 2.2e-27 95.6 6.8 2.6e-27 95.4 6.8 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family FlxA PF14282.6 EFC44053.1 - 0.006 16.6 8.3 0.006 16.6 8.3 6.9 7 1 1 8 8 8 2 FlxA-like protein MbeD_MobD PF04899.12 EFC44053.1 - 0.013 15.6 2.2 0.013 15.6 2.2 5.4 4 2 1 5 5 5 0 MbeD/MobD like OGFr_N PF04664.13 EFC44054.1 - 3.6e-55 186.7 3.3 4.9e-55 186.3 3.3 1.1 1 0 0 1 1 1 1 Opioid growth factor receptor (OGFr) conserved region Pkinase PF00069.25 EFC44055.1 - 6.6e-27 94.5 0.6 1.3e-26 93.5 0.6 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44055.1 - 1.6e-12 47.3 0.7 1.6e-12 47.3 0.7 1.7 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44055.1 - 6.1e-08 31.8 0.1 9.3e-08 31.3 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC44055.1 - 0.032 13.6 0.4 0.032 13.6 0.4 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RdRP PF05183.12 EFC44057.1 - 2.4e-100 336.9 0.2 4e-100 336.2 0.2 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase Helicase_C PF00271.31 EFC44058.1 - 1.3e-17 64.1 4.8 2.2e-17 63.4 0.2 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC44058.1 - 1.1e-13 51.5 1.0 4.7e-12 46.2 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFC44058.1 - 1.1e-10 41.5 0.1 1.6e-08 34.5 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Imm-NTF2 PF15655.6 EFC44058.1 - 0.083 13.2 1.9 1 9.7 0.0 3.1 3 1 0 3 3 3 0 NTF2 fold immunity protein Arm PF00514.23 EFC44059.1 - 1.3e-12 47.3 1.6 0.00045 20.2 0.1 5.6 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat Neurochondrin PF05536.11 EFC44059.1 - 0.0007 18.1 0.0 0.0012 17.3 0.0 1.3 1 0 0 1 1 1 1 Neurochondrin HEAT_2 PF13646.6 EFC44059.1 - 0.18 12.2 0.0 9.4 6.7 0.0 3.0 2 0 0 2 2 2 0 HEAT repeats YdjM PF04307.14 EFC44060.1 - 4.4e-16 58.7 2.3 9.2e-16 57.6 0.1 2.4 3 0 0 3 3 3 1 LexA-binding, inner membrane-associated putative hydrolase DUF2227 PF09988.9 EFC44060.1 - 0.036 13.9 2.4 0.096 12.6 0.4 2.7 2 1 0 2 2 2 0 Uncharacterized metal-binding protein (DUF2227) DUF2681 PF10883.8 EFC44060.1 - 0.13 12.6 7.8 0.86 10.0 0.5 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF2681) Kei1 PF08552.11 EFC44060.1 - 0.67 9.8 5.6 3.2 7.6 0.2 3.4 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 Tir_receptor_C PF07489.11 EFC44060.1 - 0.84 9.6 7.1 1.6 8.7 7.1 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus MaoC_dehydratas PF01575.19 EFC44061.1 - 5.6e-19 67.9 0.0 6.6e-19 67.7 0.0 1.0 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 EFC44061.1 - 1.2e-09 38.4 0.0 1.6e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase DUF4336 PF14234.6 EFC44062.1 - 0.0013 18.0 0.0 0.074 12.2 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4336) AroM PF07302.11 EFC44062.1 - 0.16 11.3 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 AroM protein WD40 PF00400.32 EFC44063.1 - 1.9e-10 41.1 5.9 0.0044 17.8 0.0 6.9 7 0 0 7 7 7 3 WD domain, G-beta repeat PQQ_3 PF13570.6 EFC44063.1 - 0.0032 17.9 0.0 0.16 12.5 0.0 3.0 4 0 0 4 4 4 1 PQQ-like domain PDDEXK_1 PF12705.7 EFC44064.1 - 5.1e-16 59.4 0.0 1.9e-07 31.3 0.0 2.2 2 0 0 2 2 2 2 PD-(D/E)XK nuclease superfamily Actin PF00022.19 EFC44065.1 - 5.1e-95 318.5 0.0 3.1e-92 309.3 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC44065.1 - 0.00059 18.8 0.0 0.061 12.1 0.0 2.3 2 1 0 2 2 2 2 MreB/Mbl protein Ovate PF04844.13 EFC44065.1 - 0.12 12.4 0.2 0.3 11.1 0.2 1.6 1 0 0 1 1 1 0 Transcriptional repressor, ovate GTP_EFTU PF00009.27 EFC44066.1 - 4.6e-10 39.4 0.0 1.4e-09 37.7 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC44066.1 - 0.00042 20.6 0.1 0.0024 18.2 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC44066.1 - 0.0055 17.1 0.0 0.017 15.5 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Fra10Ac1 PF09725.9 EFC44066.1 - 0.013 15.6 0.1 0.062 13.4 0.0 2.0 2 0 0 2 2 2 0 Folate-sensitive fragile site protein Fra10Ac1 NUMOD1 PF07453.13 EFC44067.1 - 0.14 12.5 0.5 1.9 8.8 0.1 2.5 2 0 0 2 2 2 0 NUMOD1 domain TMEM144 PF07857.12 EFC44068.1 - 3.3e-13 49.3 27.3 2.4e-12 46.5 27.3 2.5 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters EamA PF00892.20 EFC44068.1 - 0.012 15.8 11.3 0.012 15.8 11.3 2.9 2 1 0 2 2 2 0 EamA-like transporter family Gram_pos_anchor PF00746.21 EFC44068.1 - 2.6 8.1 7.2 1.1 9.3 0.9 3.2 3 0 0 3 3 3 0 LPXTG cell wall anchor motif RGS PF00615.19 EFC44069.1 - 0.00014 22.1 2.2 0.00014 22.1 2.2 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain His_Phos_1 PF00300.22 EFC44070.1 - 1.6e-25 90.0 0.0 7.8e-18 64.9 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) FH2 PF02181.23 EFC44071.1 - 9.9e-76 255.3 14.8 9.9e-76 255.3 14.8 4.7 3 2 2 5 5 5 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFC44071.1 - 8.1e-14 51.6 6.1 2.5e-08 33.7 0.9 5.5 4 1 1 5 5 5 2 Diaphanous GTPase-binding Domain zf-C4H2 PF10146.9 EFC44071.1 - 0.00048 20.5 22.1 0.00048 20.5 22.1 5.1 4 1 2 6 6 6 1 Zinc finger-containing protein DUF1843 PF08898.10 EFC44071.1 - 0.76 10.3 5.7 1.3 9.6 2.8 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) Baculo_PEP_C PF04513.12 EFC44071.1 - 5.9 6.9 25.6 0.22 11.6 0.1 4.9 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Abi_2 PF07751.11 EFC44072.1 - 0.012 15.8 0.7 0.012 15.8 0.7 1.8 2 0 0 2 2 2 0 Abi-like protein F-box_4 PF15966.5 EFC44072.1 - 0.017 15.0 0.9 0.031 14.2 0.9 1.5 1 1 0 1 1 1 0 F-box F-box-like PF12937.7 EFC44072.1 - 0.082 12.8 0.5 0.15 12.0 0.5 1.4 1 0 0 1 1 1 0 F-box-like GtrA PF04138.14 EFC44073.1 - 2.8e-09 37.2 14.0 4.2e-09 36.7 14.0 1.3 1 0 0 1 1 1 1 GtrA-like protein DUF4271 PF14093.6 EFC44073.1 - 0.0073 16.2 13.2 0.011 15.7 13.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4271) RRM_1 PF00076.22 EFC44074.1 - 3.3e-11 42.8 0.0 8e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MCC-bdg_PDZ PF10506.9 EFC44074.1 - 0.047 13.7 0.7 0.11 12.5 0.7 1.7 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TetR_C_17 PF17922.1 EFC44074.1 - 0.057 13.5 2.0 0.19 11.9 0.1 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain VEFS-Box PF09733.9 EFC44074.1 - 2.5 7.9 9.2 5.2 6.9 9.2 1.5 1 0 0 1 1 1 0 VEFS-Box of polycomb protein DHHC PF01529.20 EFC44075.1 - 7.4e-20 71.4 11.3 7.4e-20 71.4 11.3 2.7 2 2 1 3 3 3 1 DHHC palmitoyltransferase XAP5 PF04921.14 EFC44075.1 - 2.2 8.1 12.7 0.98 9.2 0.3 2.2 2 0 0 2 2 2 0 XAP5, circadian clock regulator RasGEF PF00617.19 EFC44076.1 - 4.2e-61 206.2 2.5 8.7e-61 205.2 0.5 2.5 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFC44076.1 - 8.6e-19 67.7 0.1 8.6e-19 67.7 0.1 3.1 3 1 0 3 3 3 1 RasGEF N-terminal motif PH PF00169.29 EFC44076.1 - 0.0099 16.4 1.2 0.022 15.2 0.4 2.1 2 0 0 2 2 2 1 PH domain Hemocyanin_N PF03722.14 EFC44076.1 - 0.39 11.3 3.5 0.73 10.4 0.1 3.2 3 0 0 3 3 3 0 Hemocyanin, all-alpha domain DUF4477 PF14780.6 EFC44076.1 - 1.5 8.4 7.8 18 4.9 1.6 3.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4477) adh_short PF00106.25 EFC44078.1 - 1.8e-12 47.1 2.5 2.4e-06 27.2 0.3 2.6 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC44078.1 - 1.3e-07 31.4 0.2 0.0024 17.5 0.0 2.4 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase NAD_binding_7 PF13241.6 EFC44078.1 - 0.0095 16.4 0.1 0.013 15.9 0.1 1.4 1 1 0 1 1 1 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 EFC44078.1 - 0.018 14.4 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain KR PF08659.10 EFC44078.1 - 0.025 14.5 0.1 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 KR domain Pyr_redox PF00070.27 EFC44078.1 - 0.066 13.8 0.1 0.13 12.8 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase F-box-like PF12937.7 EFC44079.1 - 0.0002 21.2 0.1 0.00045 20.0 0.0 1.6 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 EFC44079.1 - 0.095 12.3 0.2 0.47 10.1 0.1 2.2 2 0 0 2 2 2 0 F-box CENP-B_dimeris PF09026.10 EFC44079.1 - 0.12 12.8 4.5 0.32 11.4 4.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Gastrin PF00918.17 EFC44079.1 - 1.9 9.5 5.1 0.34 11.9 1.1 1.8 2 0 0 2 2 2 0 Gastrin/cholecystokinin family Pox_Ag35 PF03286.14 EFC44079.1 - 5 6.9 19.9 2.2 8.0 6.0 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein NHL PF01436.21 EFC44080.1 - 0.0041 17.1 1.0 0.28 11.3 0.0 3.3 3 0 0 3 3 3 1 NHL repeat 2_5_RNA_ligase2 PF13563.6 EFC44080.1 - 0.086 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily DUF4116 PF13475.6 EFC44081.1 - 8.3e-11 41.4 25.5 0.0028 17.4 0.4 7.0 6 1 0 6 6 6 3 Domain of unknown function (DUF4116) Prp19 PF08606.11 EFC44081.1 - 0.12 12.4 0.0 0.55 10.3 0.0 2.2 3 0 0 3 3 3 0 Prp19/Pso4-like Na_Ca_ex PF01699.24 EFC44082.1 - 1.1e-35 122.8 45.1 9.2e-19 67.9 15.4 3.6 3 1 1 4 4 4 2 Sodium/calcium exchanger protein NHL PF01436.21 EFC44083.1 - 0.14 12.2 0.7 16 5.7 0.0 4.0 3 0 0 3 3 3 0 NHL repeat Tnp_zf-ribbon_2 PF13842.6 EFC44083.1 - 0.44 11.4 15.0 2.7 8.9 2.1 3.1 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DnaJ_CXXCXGXG PF00684.19 EFC44083.1 - 2.5 8.5 15.6 4.3 7.8 13.7 2.5 2 1 0 2 2 2 0 DnaJ central domain Ras PF00071.22 EFC44084.1 - 4.8e-12 45.8 0.0 6.2e-09 35.6 0.0 3.4 3 1 0 3 3 3 2 Ras family Roc PF08477.13 EFC44084.1 - 2.3e-08 34.3 0.0 0.00015 22.0 0.0 2.7 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC44084.1 - 3.3e-08 33.3 0.7 6.7e-08 32.3 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC44084.1 - 1.8e-07 30.9 0.2 4.5e-07 29.6 0.2 1.7 1 0 0 1 1 1 1 F-box domain Arf PF00025.21 EFC44084.1 - 0.026 14.0 0.0 2.9 7.3 0.0 2.9 2 1 0 2 2 2 0 ADP-ribosylation factor family F-box_4 PF15966.5 EFC44084.1 - 0.05 13.5 0.2 0.88 9.5 0.0 2.5 2 0 0 2 2 2 0 F-box CBF PF03914.17 EFC44088.1 - 2.1e-34 119.0 0.0 2.1e-34 119.0 0.0 3.1 4 0 0 4 4 4 1 CBF/Mak21 family NOC3p PF07540.11 EFC44088.1 - 0.81 10.2 7.1 0.8 10.2 2.2 3.5 2 1 0 2 2 2 0 Nucleolar complex-associated protein Phasin PF05597.11 EFC44089.1 - 0.08 13.0 3.1 0.18 11.8 3.1 1.6 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Prominin PF05478.11 EFC44089.1 - 0.2 9.6 5.5 0.34 8.8 5.5 1.3 1 0 0 1 1 1 0 Prominin Abhydrolase_1 PF00561.20 EFC44090.1 - 2.2e-08 34.1 0.0 4.9e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 EFC44090.1 - 4.4e-05 22.9 0.2 0.00052 19.4 0.1 2.3 1 1 1 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Hydrolase_4 PF12146.8 EFC44090.1 - 0.0063 15.8 0.0 0.058 12.6 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC44090.1 - 0.0086 16.7 0.0 0.016 15.8 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family RST PF12174.8 EFC44090.1 - 0.017 15.0 0.4 2 8.4 0.1 2.7 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Alpha_L_fucos PF01120.17 EFC44090.1 - 0.021 14.3 0.5 0.094 12.1 0.2 2.1 2 1 0 2 2 2 0 Alpha-L-fucosidase Thioesterase PF00975.20 EFC44090.1 - 0.027 14.6 0.0 0.057 13.5 0.0 1.6 1 1 0 1 1 1 0 Thioesterase domain BAAT_C PF08840.11 EFC44090.1 - 0.069 13.1 1.1 0.34 10.8 0.2 2.2 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Zn_clus PF00172.18 EFC44091.1 - 3.5e-11 43.0 14.9 6.5e-11 42.2 14.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_47 PF01532.20 EFC44092.1 - 3.1e-155 517.6 1.6 4.1e-155 517.2 1.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 GlcNAc_2-epim PF07221.11 EFC44092.1 - 0.00022 20.6 0.0 0.83 8.8 0.0 3.2 4 0 0 4 4 4 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_88 PF07470.13 EFC44092.1 - 0.088 11.9 0.2 0.42 9.6 0.1 2.1 2 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 EFC44092.1 - 0.097 12.2 0.1 5 6.5 0.0 2.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 76 TPR_2 PF07719.17 EFC44094.1 - 0.0042 17.1 1.3 0.018 15.1 0.6 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44094.1 - 0.041 13.7 1.3 0.19 11.6 1.3 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44094.1 - 0.26 11.6 1.9 1.2 9.5 1.9 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Inositol_P PF00459.25 EFC44095.1 - 3.7e-39 134.9 0.0 4.7e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family BppU_N PF10651.9 EFC44095.1 - 0.018 14.8 0.2 0.8 9.4 0.2 2.4 2 1 0 2 2 2 0 BppU N-terminal domain Xol-1_N PF09108.10 EFC44096.1 - 0.016 15.1 2.3 0.11 12.3 0.3 2.5 1 1 1 2 2 2 0 Switch protein XOL-1, N-terminal Actin PF00022.19 EFC44097.1 - 6.8e-72 242.3 0.0 1.6e-69 234.5 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC44097.1 - 0.17 10.7 0.0 2.4 6.9 0.0 2.3 3 0 0 3 3 3 0 MreB/Mbl protein ABC2_membrane_3 PF12698.7 EFC44098.1 - 3.6 6.6 18.7 6.7 5.7 18.7 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein Pkinase PF00069.25 EFC44099.1 - 5.3e-83 278.4 0.1 8.4e-83 277.8 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44099.1 - 1e-46 159.4 0.0 1.4e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC44099.1 - 4.9e-11 42.5 0.0 1e-09 38.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Glycos_trans_3N PF02885.17 EFC44099.1 - 2.8e-06 27.1 0.3 0.0033 17.2 0.1 2.7 3 0 0 3 3 3 2 Glycosyl transferase family, helical bundle domain RIO1 PF01163.22 EFC44099.1 - 8.6e-06 25.5 0.5 4.8e-05 23.0 0.4 1.9 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 EFC44099.1 - 0.0019 17.6 0.1 0.0031 16.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC44099.1 - 0.0026 17.7 0.1 0.024 14.6 0.2 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC44099.1 - 0.0085 15.1 0.6 0.017 14.1 0.6 1.5 1 1 0 1 1 1 1 Haspin like kinase domain YukC PF10140.9 EFC44099.1 - 0.028 13.3 0.1 0.044 12.6 0.1 1.4 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC ABC1 PF03109.16 EFC44099.1 - 0.04 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 ABC1 family EF-hand_1 PF00036.32 EFC44100.1 - 1.4e-06 27.4 1.4 0.00038 19.8 0.0 3.6 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EFC44100.1 - 2.8e-05 24.5 4.2 0.00026 21.4 0.1 3.4 1 1 2 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC44100.1 - 4.5e-05 23.0 2.2 0.0015 18.3 0.0 3.8 4 1 1 5 5 5 1 EF-hand domain EF-hand_5 PF13202.6 EFC44100.1 - 0.0023 17.4 1.6 0.026 14.0 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_10 PF14788.6 EFC44100.1 - 0.0056 16.5 2.1 0.05 13.5 0.0 3.1 3 0 0 3 3 3 1 EF hand DUF2368 PF10166.9 EFC44100.1 - 0.0089 15.6 0.7 0.029 14.0 0.0 2.1 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2368) EF-hand_8 PF13833.6 EFC44100.1 - 0.014 15.2 0.7 0.57 10.1 0.0 3.6 3 1 0 3 3 3 0 EF-hand domain pair Rab3-GTPase_cat PF13890.6 EFC44100.1 - 0.055 13.1 1.1 0.35 10.5 1.1 2.1 1 1 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit CDC4_D PF16856.5 EFC44100.1 - 0.11 12.4 3.2 0.36 10.7 3.2 1.9 1 0 0 1 1 1 0 Cell division control protein 4 dimerisation domain SF1-HH PF16275.5 EFC44100.1 - 0.56 10.6 3.7 7.2 7.0 0.6 2.7 2 1 0 2 2 2 0 Splicing factor 1 helix-hairpin domain Rotamase_3 PF13616.6 EFC44101.1 - 2e-22 79.9 0.0 2.2e-22 79.8 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 EFC44101.1 - 1.3e-19 71.0 0.0 1.8e-19 70.5 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 EFC44101.1 - 1e-05 26.4 0.0 1.2e-05 26.1 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WD40 PF00400.32 EFC44102.1 - 9.5e-25 86.4 17.4 5.6e-06 27.0 0.1 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 EFC44102.1 - 1.2e-09 37.4 1.6 0.089 11.4 0.1 3.9 2 1 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 EFC44102.1 - 6.8e-07 29.5 0.7 0.086 13.1 0.1 4.2 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 EFC44102.1 - 6.1e-06 26.6 0.0 10 6.7 0.0 4.6 5 0 0 5 5 5 3 PQQ-like domain PQQ_2 PF13360.6 EFC44102.1 - 0.00016 21.4 0.0 0.00079 19.1 0.0 2.1 1 1 0 1 1 1 1 PQQ-like domain BBS2_Mid PF14783.6 EFC44102.1 - 0.00021 21.3 0.2 4 7.5 0.0 4.4 3 2 3 6 6 6 1 Ciliary BBSome complex subunit 2, middle region Transket_pyr PF02779.24 EFC44103.1 - 1.2e-47 161.9 0.0 1.6e-47 161.5 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFC44103.1 - 8.3e-40 135.5 0.0 2e-39 134.3 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 EFC44103.1 - 0.0065 16.8 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Rpp20 PF12328.8 EFC44103.1 - 0.16 12.0 0.5 2.9 7.8 0.0 2.2 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P FYRC PF05965.14 EFC44104.1 - 5.8e-22 77.6 1.0 2.5e-21 75.6 0.0 2.7 2 0 0 2 2 2 1 F/Y rich C-terminus FYRN PF05964.14 EFC44104.1 - 2.9e-17 62.2 0.2 5.4e-17 61.4 0.2 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus DDT PF02791.17 EFC44104.1 - 0.018 15.3 0.0 0.042 14.2 0.0 1.6 1 0 0 1 1 1 0 DDT domain Arf PF00025.21 EFC44105.1 - 1.6e-42 144.9 0.0 2.1e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFC44105.1 - 5e-09 35.8 4.1 2.4e-06 27.0 0.0 3.0 1 1 2 3 3 3 2 G-protein alpha subunit Roc PF08477.13 EFC44105.1 - 1.4e-07 31.7 0.0 2.7e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC44105.1 - 2.9e-07 30.1 0.3 2.3e-05 23.9 0.0 2.3 1 1 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC44105.1 - 4.7e-07 29.9 0.0 1.2e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EFC44105.1 - 1e-06 28.4 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Septin PF00735.18 EFC44105.1 - 0.021 14.1 2.2 0.44 9.8 0.0 2.5 2 1 0 2 2 2 0 Septin Smac_DIABLO PF09057.10 EFC44105.1 - 0.33 10.3 4.1 0.48 9.7 4.1 1.3 1 0 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases Dynamin_N PF00350.23 EFC44105.1 - 0.4 10.7 5.1 2 8.4 5.1 2.1 1 1 0 1 1 1 0 Dynamin family AAA_18 PF13238.6 EFC44105.1 - 1.6 9.3 0.0 1.6 9.3 0.0 3.1 2 1 1 3 3 3 0 AAA domain Phage_holin_3_6 PF07332.11 EFC44106.1 - 0.0017 18.4 7.2 0.0017 18.4 7.2 2.3 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III Renin_r PF07850.14 EFC44106.1 - 0.022 15.3 0.3 0.022 15.3 0.3 3.4 2 1 2 4 4 4 0 Renin receptor-like protein TarH PF02203.15 EFC44106.1 - 0.025 14.5 1.3 0.025 14.5 1.3 3.2 4 0 0 4 4 4 0 Tar ligand binding domain homologue SDF PF00375.18 EFC44106.1 - 0.18 10.8 18.6 0.18 10.8 0.2 2.1 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family DHHC PF01529.20 EFC44106.1 - 0.3 11.2 11.3 4.2 7.5 5.3 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase SKN1 PF03935.15 EFC44106.1 - 0.44 8.9 4.2 3.2 6.1 0.0 2.5 2 1 1 3 3 3 0 Beta-glucan synthesis-associated protein (SKN1) DUF4179 PF13786.6 EFC44106.1 - 0.53 10.8 5.8 7 7.2 1.5 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) LMF1 PF06762.14 EFC44106.1 - 1.5 7.8 9.0 15 4.6 9.0 1.9 1 1 0 1 1 1 0 Lipase maturation factor DUF418 PF04235.12 EFC44106.1 - 2.3 8.1 9.4 2.2 8.2 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF418) TssO PF17561.2 EFC44106.1 - 3.1 7.9 0.0 3.1 7.9 0.0 2.8 3 1 0 3 3 3 0 Type VI secretion system, TssO DUF1772 PF08592.11 EFC44106.1 - 3.8 7.8 10.2 4.1 7.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) DUF1230 PF06799.11 EFC44106.1 - 4.7 7.3 8.0 19 5.3 3.3 2.2 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 Ephrin_rec_like PF07699.13 EFC44107.1 - 3.5e-14 52.3 45.3 3.5e-07 29.9 6.1 9.9 8 2 1 9 9 9 6 Putative ephrin-receptor like TA_inhibitor PF17574.2 EFC44107.1 - 0.16 12.0 0.0 16 5.6 0.0 2.7 3 0 0 3 3 3 0 Inhibitor of toxin/antitoxin system (Gp4.5) DUF1179 PF06678.11 EFC44107.1 - 0.17 11.9 3.3 0.45 10.5 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) DUF4690 PF15756.5 EFC44107.1 - 6.1 7.5 0.0 6.1 7.5 0.0 3.5 4 0 0 4 4 4 0 Small Novel Rich in Cartilage RCC1 PF00415.18 EFC44108.1 - 4.5e-37 126.4 0.6 6.8e-13 49.0 0.0 4.5 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC44108.1 - 6.6e-20 70.4 9.2 4e-07 29.6 0.3 3.3 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat EB1 PF03271.17 EFC44108.1 - 0.09 13.0 0.0 0.29 11.4 0.0 1.8 1 0 0 1 1 1 0 EB1-like C-terminal motif SR-25 PF10500.9 EFC44108.1 - 0.17 11.4 6.9 0.26 10.9 6.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ribosomal_L6e PF01159.19 EFC44108.1 - 1.1 9.8 9.3 0.43 11.1 5.2 2.0 1 1 1 2 2 2 0 Ribosomal protein L6e Atg14 PF10186.9 EFC44109.1 - 0.0016 17.6 10.4 0.0029 16.8 10.4 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Paramyxo_P PF01806.17 EFC44109.1 - 0.041 13.3 5.4 0.29 10.6 0.0 2.9 2 1 0 2 2 2 0 Paramyxovirinae P phosphoprotein C-terminal region ADIP PF11559.8 EFC44109.1 - 0.05 13.7 12.3 1.9 8.5 10.4 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Noelin-1 PF12308.8 EFC44109.1 - 0.19 11.7 8.7 0.85 9.6 1.4 3.0 1 1 2 3 3 3 0 Neurogenesis glycoprotein YabA PF06156.13 EFC44109.1 - 0.51 11.0 8.4 0.16 12.6 2.4 2.9 3 1 1 4 4 4 0 Initiation control protein YabA FlgN PF05130.12 EFC44109.1 - 6.6 7.2 12.6 4 7.9 5.5 2.5 2 1 1 3 3 3 0 FlgN protein LRRFIP PF09738.9 EFC44110.1 - 7.9 5.9 13.0 0.21 11.0 5.2 2.2 2 0 0 2 2 2 0 LRRFIP family FSH1 PF03959.13 EFC44111.1 - 1.9e-09 37.5 0.1 5e-09 36.1 0.1 1.8 1 0 0 1 1 1 1 Serine hydrolase (FSH1) WH2 PF02205.20 EFC44111.1 - 1.7e-08 34.0 0.3 4.9e-08 32.6 0.3 1.8 1 0 0 1 1 1 1 WH2 motif VPS9 PF02204.18 EFC44111.1 - 0.00033 20.8 1.3 0.0013 18.9 1.3 2.1 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SMC_ScpB PF04079.16 EFC44111.1 - 0.082 12.5 0.6 1.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Segregation and condensation complex subunit ScpB EF1G PF00647.19 EFC44111.1 - 1.8 8.7 7.7 32 4.6 3.0 3.7 3 0 0 3 3 3 0 Elongation factor 1 gamma, conserved domain Prefoldin_2 PF01920.20 EFC44111.1 - 8.9 6.3 8.7 5.7 6.9 0.2 4.0 4 0 0 4 4 4 0 Prefoldin subunit Ras PF00071.22 EFC44112.1 - 4e-47 159.8 0.0 4.8e-47 159.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44112.1 - 2.6e-20 72.8 0.2 6.2e-20 71.6 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44112.1 - 2e-07 30.6 0.0 2.6e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC44112.1 - 0.0001 21.9 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain L51_S25_CI-B8 PF05047.16 EFC44112.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Sel1 PF08238.12 EFC44114.1 - 4.7e-64 211.4 24.8 2.2e-08 34.5 0.0 11.8 11 1 0 11 11 11 9 Sel1 repeat TPR_6 PF13174.6 EFC44114.1 - 3e-09 36.9 6.9 0.34 11.6 0.1 7.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44114.1 - 9e-08 31.6 28.0 0.023 14.5 0.3 9.7 11 1 0 11 11 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44114.1 - 3.8e-07 30.7 6.7 0.067 13.9 0.1 5.4 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44114.1 - 8.3e-06 25.5 37.2 0.081 13.1 0.6 9.4 11 1 1 12 12 12 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44114.1 - 5.3e-05 23.4 16.0 0.3 11.4 0.7 7.4 7 3 1 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44114.1 - 0.0013 19.4 1.8 13 6.9 0.0 4.7 2 1 2 4 4 4 0 Tetratricopeptide repeat Agglutinin_C PF18021.1 EFC44114.1 - 0.0072 16.8 0.1 5.7 7.5 0.0 3.4 3 0 0 3 3 3 1 Agglutinin C-terminal TPR_8 PF13181.6 EFC44114.1 - 0.0086 16.2 24.8 0.2 11.9 0.4 7.7 8 1 0 8 8 8 2 Tetratricopeptide repeat DUF3443 PF11925.8 EFC44114.1 - 0.0095 14.8 0.6 0.047 12.5 0.1 2.1 1 1 0 2 2 2 1 Protein of unknown function (DUF3443) TPR_7 PF13176.6 EFC44114.1 - 0.091 12.8 13.5 10 6.4 0.0 6.2 6 1 1 7 7 7 0 Tetratricopeptide repeat Spore_Cse60 PF10957.8 EFC44114.1 - 0.12 12.4 0.3 2.5 8.2 0.0 3.0 3 0 0 3 3 3 0 Sporulation protein Cse60 Glu-tRNAGln PF02686.15 EFC44114.1 - 0.15 12.4 0.1 0.95 9.8 0.0 2.2 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit TPR_11 PF13414.6 EFC44114.1 - 0.29 10.9 18.7 5.7 6.7 0.1 7.5 8 1 1 9 9 9 0 TPR repeat TPR_17 PF13431.6 EFC44114.1 - 1.7 9.2 14.2 11 6.6 0.0 6.2 8 0 0 8 8 6 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC44114.1 - 5.1 6.6 10.1 29 4.2 0.0 4.5 5 0 0 5 5 5 0 SHNi-TPR RCC1 PF00415.18 EFC44115.1 - 5.4e-29 100.6 1.5 0.00069 20.2 0.0 8.3 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC44115.1 - 7.2e-28 95.8 17.9 1.9e-07 30.7 0.1 8.1 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Lipocalin_2 PF08212.12 EFC44116.1 - 2.2e-23 82.8 0.0 2.8e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 EFC44116.1 - 4.8e-14 52.8 0.0 6e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Peptidase_C33 PF05412.12 EFC44116.1 - 0.0073 16.3 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Equine arterivirus Nsp2-type cysteine proteinase Triabin PF03973.13 EFC44116.1 - 0.0079 16.1 0.6 0.021 14.7 0.6 1.6 1 1 0 1 1 1 1 Triabin Mpv17_PMP22 PF04117.12 EFC44117.1 - 5.6e-16 58.5 1.6 1.1e-15 57.6 0.6 1.9 2 0 0 2 2 2 1 Mpv17 / PMP22 family Zip PF02535.22 EFC44118.1 - 6.4e-22 78.2 7.8 1.7e-21 76.8 7.8 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter Mt_ATP-synt_B PF05405.14 EFC44118.1 - 0.019 14.6 0.2 0.036 13.7 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Pex24p PF06398.11 EFC44118.1 - 0.18 10.8 1.6 0.24 10.3 0.4 1.8 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin zf-AN1 PF01428.16 EFC44119.1 - 6.3e-15 55.1 47.9 9.8e-09 35.2 20.7 3.0 3 0 0 3 3 3 2 AN1-like Zinc finger LRR_4 PF12799.7 EFC44120.1 - 0.081 13.4 16.1 14 6.3 0.6 7.3 3 3 5 8 8 8 0 Leucine Rich repeats (2 copies) UCH PF00443.29 EFC44121.1 - 2.2e-41 142.0 0.9 4.6e-41 141.0 0.9 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 EFC44121.1 - 4.2e-27 93.7 0.6 4.6e-25 87.2 0.2 2.7 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 EFC44121.1 - 4.6e-17 62.1 1.5 2.1e-16 60.0 0.1 2.5 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 EFC44121.1 - 7.1e-13 48.2 0.1 1.7e-07 31.0 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 EFC44121.1 - 1.9e-11 44.1 7.5 8.3e-10 38.8 7.5 2.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PS_Dcarbxylase PF02666.15 EFC44122.1 - 3.5e-55 186.7 5.4 2.5e-54 183.9 5.4 2.0 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase SDF PF00375.18 EFC44122.1 - 0.17 10.8 0.0 0.17 10.8 0.0 1.2 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family Presenilin PF01080.17 EFC44122.1 - 0.62 8.8 2.5 4.9 5.8 0.3 2.2 2 0 0 2 2 2 0 Presenilin NFACT-R_1 PF05670.13 EFC44123.1 - 6.1e-40 136.3 0.7 1.1e-39 135.4 0.1 1.8 1 1 1 2 2 2 1 NFACT protein RNA binding domain DUF2368 PF10166.9 EFC44123.1 - 1.2 8.8 4.9 2 8.0 4.9 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Peptidase_S49_N PF08496.10 EFC44123.1 - 2.7 8.0 11.8 4.3 7.4 11.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ank_2 PF12796.7 EFC44124.1 - 2.4e-22 79.3 1.3 4.5e-09 36.8 0.4 5.9 3 2 4 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC44124.1 - 7e-15 55.2 5.1 0.0007 20.1 0.1 6.7 4 3 0 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC44124.1 - 7.2e-13 48.5 3.9 0.031 14.6 0.0 6.9 6 1 1 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC44124.1 - 1.9e-12 46.2 7.0 0.013 16.0 0.0 8.3 9 0 0 9 9 9 2 Ankyrin repeat Ank PF00023.30 EFC44124.1 - 5.2e-12 45.6 0.2 0.0088 16.5 0.1 6.5 8 0 0 8 8 8 3 Ankyrin repeat DUF16 PF01519.16 EFC44124.1 - 0.054 14.0 2.3 0.17 12.4 2.3 1.9 1 0 0 1 1 1 0 Protein of unknown function DUF16 XLF PF09302.11 EFC44124.1 - 0.093 12.9 3.2 0.096 12.8 1.2 2.1 2 0 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component TRAF_BIRC3_bd PF16673.5 EFC44124.1 - 1.5 8.6 7.4 3.4 7.5 4.2 2.9 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain TMF_DNA_bd PF12329.8 EFC44124.1 - 6.2 6.9 10.9 0.2 11.6 3.8 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Aldo_ket_red PF00248.21 EFC44125.1 - 1e-76 257.9 0.1 1.2e-76 257.8 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PTB PF08416.13 EFC44125.1 - 0.11 12.6 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 Phosphotyrosine-binding domain UPF0220 PF05255.11 EFC44126.1 - 5.7e-20 71.5 7.8 6.6e-20 71.3 7.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) FeoB_C PF07664.12 EFC44126.1 - 0.37 10.5 3.1 10 5.9 0.1 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus EMP24_GP25L PF01105.24 EFC44127.1 - 3.7e-49 167.1 0.2 4.3e-49 166.9 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Synapsin_N PF10581.9 EFC44128.1 - 0.12 12.3 0.2 0.12 12.3 0.2 2.0 2 0 0 2 2 2 0 Synapsin N-terminal Nore1-SARAH PF16517.5 EFC44128.1 - 0.5 10.3 4.8 0.25 11.3 1.8 2.1 2 0 0 2 2 2 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain DUF483 PF04467.12 EFC44128.1 - 0.92 9.5 5.3 1.1 9.3 1.2 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF483) PhoLip_ATPase_C PF16212.5 EFC44129.1 - 4.1e-67 226.5 31.3 4.1e-67 226.5 31.3 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC44129.1 - 1.5e-22 79.1 3.4 1.5e-22 79.1 3.4 2.8 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFC44129.1 - 1.8e-11 43.9 1.1 3.8e-11 42.9 0.0 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC44129.1 - 1.5e-08 35.2 1.3 0.00065 20.0 0.1 3.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC44129.1 - 0.0028 17.5 0.5 0.0028 17.5 0.5 2.3 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC44129.1 - 0.0075 16.3 0.0 0.033 14.3 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) ADIP PF11559.8 EFC44130.1 - 0.0018 18.4 21.9 0.0018 18.4 21.9 6.2 3 2 4 7 7 7 1 Afadin- and alpha -actinin-Binding Fungal_TACC PF12709.7 EFC44130.1 - 0.0044 17.4 4.0 0.0044 17.4 4.0 7.4 3 2 5 8 8 8 1 Fungal Transforming acidic coiled-coil (TACC) proteins RTP1_C1 PF10363.9 EFC44130.1 - 0.0048 17.1 0.9 0.21 11.8 0.4 3.7 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnn_1N PF07989.11 EFC44130.1 - 0.0057 16.8 10.4 0.0057 16.8 10.4 6.0 3 1 3 6 6 6 2 Centrosomin N-terminal motif 1 Pox_A_type_inc PF04508.12 EFC44130.1 - 0.65 10.0 7.3 1.4 8.9 0.5 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat RRM_1 PF00076.22 EFC44131.1 - 6e-16 58.0 0.1 9.7e-16 57.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC44131.1 - 0.0021 18.1 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif RRM_Rrp7 PF17799.1 EFC44131.1 - 0.046 13.5 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain PHM7_cyt PF14703.6 EFC44131.1 - 0.11 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Secretin_N_2 PF07655.13 EFC44131.1 - 5.6 7.6 12.1 10 6.7 12.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain MCM PF00493.23 EFC44132.1 - 1.7e-91 305.3 0.1 3e-91 304.5 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC44132.1 - 2.2e-28 98.6 0.1 6.5e-28 97.1 0.0 1.9 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 EFC44132.1 - 9.6e-26 90.0 0.6 2.3e-25 88.8 0.6 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFC44132.1 - 6.6e-08 32.2 0.1 5.7e-07 29.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFC44132.1 - 1.3e-05 25.1 0.0 2.7e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MCM_N PF14551.6 EFC44132.1 - 7.7e-05 23.2 4.8 0.00024 21.7 1.2 3.0 2 1 0 2 2 2 1 MCM N-terminal domain Sigma54_activat PF00158.26 EFC44132.1 - 0.0054 16.5 0.0 0.024 14.4 0.0 2.0 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.14 EFC44132.1 - 0.0076 16.3 0.0 0.029 14.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DEAD PF00270.29 EFC44132.1 - 0.08 12.7 0.2 0.23 11.2 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 EFC44132.1 - 0.16 12.4 2.1 0.44 11.0 0.0 2.8 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DUF4586 PF15239.6 EFC44133.1 - 2.4e-47 162.6 23.4 3.1e-47 162.2 23.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4586) Ras PF00071.22 EFC44134.1 - 1.2e-42 145.3 1.0 1.4e-42 145.0 1.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44134.1 - 8e-20 71.3 0.1 1.1e-19 70.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44134.1 - 2.6e-10 40.0 0.2 3.1e-10 39.8 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EFC44134.1 - 2.1e-07 31.0 3.7 1.4e-05 25.0 0.4 2.1 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EFC44134.1 - 5.7e-07 29.3 1.0 1.2e-06 28.2 0.4 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC44134.1 - 9.8e-07 28.9 0.1 1.4e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC44134.1 - 4.4e-05 22.9 0.5 5.3e-05 22.7 0.5 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFC44134.1 - 0.001 18.3 0.6 0.29 10.2 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit RsgA_GTPase PF03193.16 EFC44134.1 - 0.018 14.9 1.1 1.1 9.2 0.3 2.5 2 1 1 3 3 3 0 RsgA GTPase DUF2024 PF09630.10 EFC44134.1 - 0.024 14.5 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) Prefoldin_2 PF01920.20 EFC44134.1 - 0.043 13.8 0.3 0.083 12.9 0.3 1.4 1 0 0 1 1 1 0 Prefoldin subunit NB-ARC PF00931.22 EFC44134.1 - 0.055 12.6 0.4 0.076 12.2 0.4 1.5 1 1 0 1 1 1 0 NB-ARC domain CbiA PF01656.23 EFC44134.1 - 0.089 12.8 0.2 0.21 11.6 0.2 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 EFC44134.1 - 0.11 13.0 0.0 0.17 12.4 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFC44134.1 - 0.22 11.9 0.2 0.86 10.0 0.2 2.1 1 1 0 1 1 1 0 AAA ATPase domain BTB_2 PF02214.22 EFC44135.1 - 1.7e-10 41.1 0.1 3.4e-10 40.1 0.1 1.4 1 1 0 1 1 1 1 BTB/POZ domain BTB PF00651.31 EFC44135.1 - 0.087 13.1 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 BTB/POZ domain Serpin PF00079.20 EFC44137.1 - 2.6e-83 280.4 4.3 3.5e-83 280.0 4.3 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Collagen PF01391.18 EFC44138.1 - 0.00014 21.5 24.2 0.00014 21.5 24.2 6.1 4 2 1 5 5 5 2 Collagen triple helix repeat (20 copies) DUF4795 PF16043.5 EFC44138.1 - 0.042 13.4 1.4 0.07 12.7 0.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) p450 PF00067.22 EFC44139.1 - 7.5e-65 219.5 0.1 8.6e-65 219.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PIN_5 PF08745.11 EFC44139.1 - 0.023 14.1 0.2 0.2 11.1 0.1 2.2 2 0 0 2 2 2 0 PINc domain ribonuclease TraL PF07178.11 EFC44141.1 - 0.026 15.0 1.1 0.047 14.2 0.2 1.8 2 0 0 2 2 2 0 TraL protein GRA6 PF05084.13 EFC44141.1 - 0.46 10.4 2.7 0.91 9.4 2.7 1.5 1 0 0 1 1 1 0 Granule antigen protein (GRA6) Peptidase_S13 PF02113.15 EFC44142.1 - 4.5e-57 193.7 0.0 6.3e-57 193.3 0.0 1.1 1 0 0 1 1 1 1 D-Ala-D-Ala carboxypeptidase 3 (S13) family zf-MYND PF01753.18 EFC44143.1 - 2.8e-11 43.3 19.9 5.7e-11 42.3 19.9 1.6 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 EFC44143.1 - 0.052 13.4 11.3 0.15 11.9 11.3 1.9 1 0 0 1 1 1 0 HIT zinc finger zf-C6H2 PF15801.5 EFC44143.1 - 0.061 13.6 13.4 0.18 12.1 13.4 1.8 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding IDO PF01231.18 EFC44143.1 - 0.13 11.1 0.9 1.4 7.6 0.4 2.1 2 0 0 2 2 2 0 Indoleamine 2,3-dioxygenase REJ PF02010.15 EFC44145.1 - 2.4e-14 53.0 5.1 1.2e-13 50.7 3.7 2.4 1 1 1 2 2 2 1 REJ domain UPF0669 PF17065.5 EFC44145.1 - 5.7e-06 26.2 0.2 0.0059 16.4 0.0 4.3 5 0 0 5 5 5 1 Putative cytokine, C6ORF120 PPC PF04151.15 EFC44145.1 - 0.019 16.0 34.3 0.094 13.8 1.0 7.5 6 2 1 7 7 7 0 Bacterial pre-peptidase C-terminal domain Tmpp129 PF10272.9 EFC44145.1 - 0.22 10.8 1.6 0.5 9.6 1.6 1.6 1 0 0 1 1 1 0 Putative transmembrane protein precursor FeoB_associated PF12669.7 EFC44145.1 - 0.47 10.9 1.9 1.1 9.7 1.9 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein GPI-anchored PF10342.9 EFC44145.1 - 0.93 10.3 7.6 0.23 12.3 0.6 3.7 3 1 1 4 4 4 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CesT PF05932.13 EFC44146.1 - 1.6e-05 25.0 0.0 0.11 12.6 0.0 2.7 2 0 0 2 2 2 2 Tir chaperone protein (CesT) family Headcase PF16002.5 EFC44146.1 - 0.48 9.8 5.5 0.046 13.2 0.3 2.0 2 0 0 2 2 2 0 Headcase protein TPR_1 PF00515.28 EFC44147.1 - 6e-24 82.8 26.3 3.6e-07 29.7 0.6 7.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44147.1 - 3e-23 80.0 19.6 1.1e-06 28.3 0.1 6.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44147.1 - 6.2e-18 63.5 17.6 4.7e-05 23.3 0.2 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44147.1 - 6.4e-17 61.6 14.2 0.0057 16.9 0.0 5.8 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44147.1 - 8.3e-10 38.7 0.1 0.068 14.0 0.0 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44147.1 - 5.3e-07 29.9 5.3 0.33 11.7 0.1 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44147.1 - 9e-07 28.5 8.2 0.16 12.1 0.1 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44147.1 - 2e-06 28.2 0.8 0.001 19.6 0.0 4.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44147.1 - 1.8e-05 25.3 0.1 0.022 15.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC44147.1 - 4.4e-05 23.5 0.0 0.00046 20.3 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 EFC44147.1 - 5.9e-05 22.2 6.4 0.037 12.9 0.7 2.9 2 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_11 PF13414.6 EFC44147.1 - 0.00026 20.6 11.1 0.092 12.5 1.8 5.2 5 2 2 7 7 7 2 TPR repeat ANAPC3 PF12895.7 EFC44147.1 - 0.00038 20.6 2.6 0.00038 20.6 2.6 4.3 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC44147.1 - 0.0084 16.4 9.0 10 6.7 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 EFC44147.1 - 0.015 15.4 14.7 0.082 13.0 0.4 4.9 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EFC44147.1 - 0.033 14.2 16.6 0.77 9.9 0.2 4.7 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 EFC44147.1 - 0.12 13.1 6.3 23 5.8 0.2 4.4 4 1 0 4 4 4 0 Sel1 repeat TPR_10 PF13374.6 EFC44147.1 - 0.14 12.1 10.1 1.9 8.4 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat HTH_Bact PF18768.1 EFC44147.1 - 8 6.1 7.5 19 4.9 0.3 3.4 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain Peptidase_C39_2 PF13529.6 EFC44148.1 - 3.8e-12 47.0 0.0 5.6e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFC44148.1 - 0.00045 20.2 0.0 0.001 19.1 0.0 1.6 1 1 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 DUF3335 PF11814.8 EFC44148.1 - 0.085 12.3 0.1 0.15 11.5 0.0 1.5 2 0 0 2 2 2 0 Peptidase_C39 like family Guanylate_cyc_2 PF09778.9 EFC44148.1 - 0.15 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Guanylylate cyclase HATPase_c PF02518.26 EFC44149.1 - 9.6e-23 80.8 0.2 2.1e-22 79.7 0.2 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC44149.1 - 8.9e-18 64.5 0.2 1.6e-17 63.6 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_5 PF14501.6 EFC44149.1 - 0.014 15.2 0.9 0.041 13.8 0.9 1.8 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 EFC44149.1 - 0.016 15.0 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Bot1p PF12298.8 EFC44149.1 - 0.034 14.3 0.4 0.059 13.5 0.4 1.3 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein RasGEF PF00617.19 EFC44150.1 - 6.1e-48 163.4 2.0 1.1e-47 162.6 0.2 2.5 2 0 0 2 2 2 1 RasGEF domain DOCK-C2 PF14429.6 EFC44150.1 - 1.6e-27 96.6 5.3 1.7e-27 96.5 1.3 3.0 3 0 0 3 3 3 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC44150.1 - 8.1e-08 32.5 6.6 1e-07 32.1 0.4 3.8 2 0 0 2 2 2 1 RasGEF N-terminal motif PAH PF02671.21 EFC44150.1 - 0.037 14.2 1.8 0.094 12.9 0.0 2.8 3 0 0 3 3 3 0 Paired amphipathic helix repeat DUF5339 PF17274.2 EFC44150.1 - 0.28 12.0 6.3 0.14 13.0 0.4 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5339) DUF5407 PF17401.2 EFC44151.1 - 0.018 15.3 2.4 2 8.7 0.8 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5407) Arm_3 PF16186.5 EFC44151.1 - 0.055 13.0 0.1 1.6 8.3 0.0 2.8 2 0 0 2 2 2 0 Atypical Arm repeat HIGH_NTase1_ass PF16581.5 EFC44151.1 - 0.093 12.7 1.9 0.18 11.8 0.3 2.2 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region ZZ PF00569.17 EFC44152.1 - 7.5e-07 28.9 7.1 7.5e-07 28.9 7.1 3.5 3 1 0 3 3 3 1 Zinc finger, ZZ type C1_2 PF03107.16 EFC44152.1 - 0.0018 18.5 5.8 0.0018 18.5 5.8 3.8 4 0 0 4 4 4 2 C1 domain zf-PARP PF00645.18 EFC44152.1 - 0.0036 18.1 0.5 0.0036 18.1 0.5 2.7 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-C3HC4_3 PF13920.6 EFC44152.1 - 0.029 14.3 4.7 0.029 14.3 4.7 3.9 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.22 EFC44152.1 - 0.28 11.1 13.3 0.19 11.7 4.5 3.2 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4428 PF14471.6 EFC44152.1 - 3.9 7.5 17.5 5.5 7.0 2.6 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4428) DZR PF12773.7 EFC44152.1 - 9.2 6.4 20.6 56 3.9 0.2 4.2 2 1 0 2 2 2 0 Double zinc ribbon Pro_isomerase PF00160.21 EFC44154.1 - 1.6e-49 168.2 0.4 1.9e-49 167.9 0.4 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD F-box-like PF12937.7 EFC44155.1 - 1.3e-10 41.0 0.0 4.4e-10 39.3 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC44155.1 - 3.4e-08 33.2 0.0 9.2e-08 31.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain Tad PF13400.6 EFC44155.1 - 6.2 7.2 0.0 6.2 7.2 0.0 3.7 4 1 1 5 5 5 0 Putative Flp pilus-assembly TadE/G-like DUF455 PF04305.14 EFC44156.1 - 1.5e-77 260.5 0.1 1.7e-77 260.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF455) zf-CCHC_3 PF13917.6 EFC44157.1 - 2.7e-17 62.4 2.3 5.7e-17 61.4 2.3 1.6 1 0 0 1 1 1 1 Zinc knuckle Kisspeptin PF15152.6 EFC44157.1 - 0.68 10.8 7.2 0.072 13.9 1.5 2.4 2 0 0 2 2 2 0 Kisspeptin GerD PF17898.1 EFC44158.1 - 0.12 12.3 2.8 0.18 11.8 0.8 2.2 2 0 0 2 2 2 0 Spore germination GerD central core domain LRR_6 PF13516.6 EFC44159.1 - 2.7e-33 111.2 37.1 0.003 17.5 0.1 16.3 16 0 0 16 16 16 10 Leucine Rich repeat LRR_4 PF12799.7 EFC44159.1 - 3e-18 65.6 54.6 1.9e-05 24.9 1.6 9.8 6 3 5 11 11 11 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC44159.1 - 8.4e-08 31.7 28.8 8.7 7.3 0.3 11.1 10 0 0 10 10 10 2 Leucine Rich Repeat LRR_8 PF13855.6 EFC44159.1 - 6.1e-05 22.7 52.5 0.014 15.1 2.0 10.9 8 3 3 11 11 11 5 Leucine rich repeat YjcQ PF09639.10 EFC44159.1 - 2.1 8.6 8.4 20 5.5 0.1 5.5 5 2 2 7 7 7 0 YjcQ protein Pkinase PF00069.25 EFC44160.1 - 5.4e-25 88.3 0.6 7.3e-25 87.8 0.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44160.1 - 6.2e-14 51.9 0.1 8.7e-14 51.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44160.1 - 0.0023 16.8 0.1 0.0045 15.8 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC44160.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GDI PF00996.18 EFC44161.1 - 3.6e-137 457.4 0.7 4.1e-137 457.3 0.7 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EFC44161.1 - 0.047 13.9 0.0 0.087 13.1 0.0 1.4 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thioredoxin PF00085.20 EFC44162.1 - 1.9e-25 88.8 0.0 2.2e-25 88.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFC44162.1 - 1.3e-07 32.0 0.0 3e-07 30.9 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain ERp29_N PF07912.13 EFC44162.1 - 6.5e-06 26.3 0.3 1.8e-05 24.9 0.3 1.6 1 1 0 1 1 1 1 ERp29, N-terminal domain Thioredoxin_8 PF13905.6 EFC44162.1 - 9.1e-06 25.9 0.0 0.0026 18.0 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 EFC44162.1 - 2.3e-05 23.9 0.0 3.5e-05 23.3 0.0 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 EFC44162.1 - 0.00063 19.6 0.0 0.00076 19.4 0.0 1.2 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_6 PF13848.6 EFC44162.1 - 0.004 17.1 0.0 0.025 14.5 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFC44162.1 - 0.0047 17.1 0.1 0.011 15.9 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_4 PF13462.6 EFC44162.1 - 0.094 12.9 0.1 0.68 10.1 0.0 1.9 1 1 1 2 2 2 0 Thioredoxin Fimbrial_PilY2 PF14481.6 EFC44162.1 - 0.12 12.0 0.0 0.3 10.8 0.0 1.6 2 0 0 2 2 2 0 Type 4 fimbrial biogenesis protein PilY2 DAP_epimerase PF01678.19 EFC44163.1 - 3.6e-33 114.3 0.1 1.1e-19 70.8 0.1 3.1 2 1 0 2 2 2 2 Diaminopimelate epimerase PRMT5 PF05185.16 EFC44164.1 - 1.2e-58 197.8 0.0 3.8e-58 196.1 0.0 1.9 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 EFC44164.1 - 4.2e-49 166.8 0.6 6.3e-49 166.2 0.6 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Oxidored_q6 PF01058.22 EFC44165.1 - 1.9e-20 73.0 0.0 2.4e-20 72.7 0.0 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DUF4064 PF13273.6 EFC44166.1 - 0.024 14.9 4.6 1.1 9.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) HSR PF03172.13 EFC44166.1 - 0.1 12.8 4.5 0.4 10.8 1.3 2.6 2 0 0 2 2 2 0 HSR domain MgtE PF01769.16 EFC44166.1 - 0.15 12.4 2.3 0.85 10.0 0.2 2.1 2 0 0 2 2 2 0 Divalent cation transporter Reprolysin_2 PF13574.6 EFC44167.1 - 0.075 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M78 PF06114.13 EFC44167.1 - 0.098 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 IrrE N-terminal-like domain IU_nuc_hydro PF01156.19 EFC44168.1 - 9.5e-44 150.2 0.1 1.2e-43 149.9 0.1 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Zn_clus PF00172.18 EFC44169.1 - 1.7e-05 24.8 7.5 3.8e-05 23.7 7.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain C2 PF00168.30 EFC44171.1 - 3.8e-09 36.8 0.0 0.00035 20.8 0.0 2.7 2 0 0 2 2 2 2 C2 domain CDC45 PF02724.14 EFC44171.1 - 4 5.6 13.3 7.6 4.7 13.3 1.4 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 EFC44171.1 - 6.2 7.0 21.5 0.11 12.7 11.4 2.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 2OG-FeII_Oxy_2 PF13532.6 EFC44172.1 - 1.3e-36 126.7 0.1 1.6e-36 126.3 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2120 PF09893.9 EFC44173.1 - 0.21 11.7 1.9 0.4 10.8 0.5 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) SNF2_N PF00176.23 EFC44174.1 - 1.1e-47 162.5 0.4 1.1e-47 162.5 0.4 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC44174.1 - 7.7e-20 71.3 0.3 8.5e-19 67.9 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC44174.1 - 8e-15 55.3 1.5 3e-14 53.4 0.1 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFC44174.1 - 4.7e-09 35.8 2.2 1.6e-08 34.1 2.2 1.9 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 EFC44174.1 - 2.5e-06 27.4 0.0 6.8e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C_2 PF13307.6 EFC44174.1 - 0.024 14.8 3.8 0.025 14.8 0.1 2.9 3 1 1 4 4 4 0 Helicase C-terminal domain BRO1 PF03097.18 EFC44176.1 - 1e-88 297.8 9.3 1e-88 297.8 9.3 2.6 4 0 0 4 4 4 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 EFC44176.1 - 1.6e-55 188.5 24.3 1.6e-55 188.5 24.3 1.8 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV HOIP-UBA PF16678.5 EFC44176.1 - 0.0077 16.2 0.3 0.0077 16.2 0.3 3.0 4 0 0 4 4 4 1 HOIP UBA domain pair PRAS PF15798.5 EFC44178.1 - 0.039 14.6 3.8 0.07 13.7 0.7 2.2 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 NLPC_P60 PF00877.19 EFC44179.1 - 2e-11 43.8 0.0 3.9e-11 42.9 0.0 1.4 1 1 0 1 1 1 1 NlpC/P60 family Amidase_5 PF05382.13 EFC44179.1 - 5.3e-08 32.9 2.6 2.1e-07 30.9 1.3 2.4 2 1 0 2 2 2 1 Bacteriophage peptidoglycan hydrolase SH3_3 PF08239.11 EFC44179.1 - 2.4e-06 27.7 0.4 2.3e-05 24.6 0.1 2.5 3 0 0 3 3 3 1 Bacterial SH3 domain Peptidase_C92 PF05708.12 EFC44179.1 - 0.0049 17.0 0.2 1.2 9.2 0.1 2.2 1 1 1 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Fim-adh_lectin PF09222.10 EFC44179.1 - 0.0086 15.6 1.0 0.065 12.7 0.0 2.0 1 1 1 2 2 2 1 Fimbrial adhesin F17-AG, lectin domain SH3_4 PF06347.13 EFC44179.1 - 0.0093 15.8 0.0 0.027 14.3 0.0 1.8 1 1 0 1 1 1 1 Bacterial SH3 domain RWP-RK PF02042.15 EFC44180.1 - 1.4e-19 69.8 0.1 3.5e-19 68.5 0.1 1.8 1 0 0 1 1 1 1 RWP-RK domain HTH_37 PF13744.6 EFC44180.1 - 0.049 13.6 0.3 0.2 11.6 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain TolA_bind_tri PF16331.5 EFC44180.1 - 0.05 13.7 1.7 0.05 13.7 1.7 2.1 2 0 0 2 2 2 0 TolA binding protein trimerisation HTH_17 PF12728.7 EFC44180.1 - 0.089 13.0 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r3 PF04539.16 EFC44180.1 - 0.11 12.7 0.7 0.27 11.4 0.1 2.0 2 0 0 2 2 2 0 Sigma-70 region 3 HMG_box PF00505.19 EFC44181.1 - 2.8e-14 53.3 0.3 6.2e-14 52.2 0.3 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC44181.1 - 2.8e-08 34.2 0.4 5.6e-08 33.3 0.4 1.5 1 0 0 1 1 1 1 HMG-box domain GTP_EFTU PF00009.27 EFC44182.1 - 5.7e-54 182.6 0.1 1.1e-53 181.7 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC44182.1 - 1.3e-39 134.9 0.1 3e-39 133.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC44182.1 - 2.1e-13 50.5 0.1 7.6e-13 48.7 0.1 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC44182.1 - 7.6e-09 35.7 0.5 7.1e-06 26.1 0.0 2.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase NIF3 PF01784.18 EFC44182.1 - 0.0019 17.9 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Roc PF08477.13 EFC44182.1 - 0.011 15.9 1.0 0.078 13.2 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC44182.1 - 0.016 14.7 0.1 0.048 13.1 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 EFC44182.1 - 0.017 15.0 0.6 0.055 13.4 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Ras PF00071.22 EFC44182.1 - 0.062 12.9 0.8 0.15 11.6 0.1 1.9 2 0 0 2 2 2 0 Ras family Pur_ac_phosph_N PF16656.5 EFC44183.1 - 2.8e-15 56.7 0.2 7.1e-15 55.4 0.2 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 EFC44183.1 - 3.3e-13 50.3 1.7 5.8e-13 49.5 0.2 2.3 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 EFC44183.1 - 5.7e-11 43.3 5.2 1e-10 42.5 5.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase F-box-like PF12937.7 EFC44185.1 - 0.0016 18.3 0.1 0.0045 16.9 0.1 1.8 1 0 0 1 1 1 1 F-box-like DUF2015 PF09435.10 EFC44185.1 - 0.38 10.6 2.8 0.44 10.4 1.6 1.7 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2015) TPR_1 PF00515.28 EFC44186.1 - 1.7e-37 125.7 10.1 1.7e-09 37.1 0.4 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44186.1 - 1.7e-32 108.8 4.7 1.6e-07 30.9 0.8 6.8 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_9 PF13371.6 EFC44186.1 - 3.9e-19 68.6 0.0 3.8e-06 26.9 0.0 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44186.1 - 5.3e-19 66.8 10.5 0.00071 19.6 0.2 6.9 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC44186.1 - 5.1e-18 64.1 4.3 2.2e-06 27.6 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44186.1 - 5.9e-18 64.3 6.8 2e-06 27.4 0.1 6.1 3 2 4 7 7 7 3 TPR repeat TPR_16 PF13432.6 EFC44186.1 - 8.5e-16 58.3 0.0 1.1e-05 25.9 0.0 3.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44186.1 - 3.1e-13 49.8 2.3 2.8e-05 24.3 0.3 5.7 2 2 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44186.1 - 4.5e-12 45.7 0.0 0.1 13.5 0.0 6.5 3 3 4 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44186.1 - 1e-11 45.2 0.6 0.014 15.9 0.0 4.8 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44186.1 - 1.1e-10 41.4 4.0 0.059 14.0 0.0 6.4 6 1 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC44186.1 - 6e-10 39.2 2.6 0.0089 16.2 0.3 4.5 2 1 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFC44186.1 - 1.1e-09 37.7 1.2 0.021 14.8 0.2 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC44186.1 - 3.5e-08 32.7 4.1 0.00088 18.7 0.0 4.5 4 0 0 4 4 4 1 SHNi-TPR TPR_10 PF13374.6 EFC44186.1 - 1.3e-07 31.3 2.5 0.0061 16.4 0.9 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFC44186.1 - 0.00014 21.2 0.1 0.074 12.3 0.0 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC44186.1 - 0.00022 21.2 3.7 0.11 12.6 0.1 4.6 4 1 1 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFC44186.1 - 0.00022 21.2 1.1 1.9 8.6 0.0 4.2 4 1 1 5 5 4 1 MIT (microtubule interacting and transport) domain SNAP PF14938.6 EFC44186.1 - 0.00027 20.5 1.8 0.0012 18.3 0.4 2.4 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_20 PF14561.6 EFC44186.1 - 0.00085 19.6 0.2 0.39 11.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat YfiO PF13525.6 EFC44186.1 - 0.0039 16.9 1.8 1.9 8.2 0.0 2.7 2 1 0 2 2 2 2 Outer membrane lipoprotein Sec5 PF15469.6 EFC44186.1 - 0.052 13.4 1.8 0.65 9.8 0.1 2.7 2 1 0 2 2 2 0 Exocyst complex component Sec5 TPR_21 PF09976.9 EFC44186.1 - 0.082 12.6 0.3 31 4.2 0.0 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain HTH_Bact PF18768.1 EFC44186.1 - 0.67 9.6 3.3 4.6 6.9 0.1 3.3 4 1 1 5 5 3 0 Helix-turn-helix bacterial domain DUF3887 PF13026.6 EFC44186.1 - 0.89 10.4 5.2 2.1 9.2 0.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3887) DUF5101 PF17031.5 EFC44186.1 - 1.9 8.6 5.3 1.3 9.1 0.3 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF5101) DUF4118 PF13493.6 EFC44187.1 - 0.0016 18.2 1.6 0.0016 18.2 1.6 4.5 5 0 0 5 5 5 1 Domain of unknown function (DUF4118) Beta_helix PF13229.6 EFC44188.1 - 3.2e-40 137.6 115.4 2.4e-13 50.2 29.0 8.5 5 3 4 9 9 9 5 Right handed beta helix region Kelch_5 PF13854.6 EFC44188.1 - 7.2e-10 38.6 5.0 7.8e-05 22.6 0.0 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFC44188.1 - 3.2e-06 26.6 5.0 0.0077 15.8 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EFC44188.1 - 1.1e-05 25.4 0.5 0.00063 19.7 0.1 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain F-box-like PF12937.7 EFC44188.1 - 0.012 15.4 0.1 0.04 13.8 0.1 1.9 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC44188.1 - 0.076 12.9 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 F-box domain Kelch_2 PF07646.15 EFC44188.1 - 0.13 12.3 6.4 1.9 8.6 0.1 4.1 3 0 0 3 3 3 0 Kelch motif Gemini_mov PF01708.16 EFC44189.1 - 0.12 12.1 0.0 9.2 6.1 0.0 2.6 2 0 0 2 2 2 0 Geminivirus putative movement protein Phage_Gp23 PF10669.9 EFC44189.1 - 0.27 11.6 4.3 5.8 7.3 0.3 2.6 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) TMEM43 PF07787.12 EFC44189.1 - 2 7.8 6.0 3.1 7.1 6.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 START PF01852.19 EFC44190.1 - 2.2e-08 33.8 0.8 3.1e-08 33.3 0.8 1.2 1 0 0 1 1 1 1 START domain WW PF00397.26 EFC44190.1 - 0.3 11.2 3.5 0.29 11.3 0.6 2.2 2 0 0 2 2 2 0 WW domain SRI PF08236.11 EFC44190.1 - 0.31 11.2 2.7 2.4 8.4 0.3 2.3 1 1 1 2 2 2 0 SRI (Set2 Rpb1 interacting) domain SURF2 PF05477.11 EFC44191.1 - 0.36 10.5 3.1 0.46 10.1 3.1 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) RdRP PF05183.12 EFC44192.1 - 1.2e-74 252.0 0.3 2.9e-74 250.8 0.0 1.7 2 0 0 2 2 2 1 RNA dependent RNA polymerase TLD PF07534.16 EFC44192.1 - 7.2e-09 36.0 2.3 7.2e-09 36.0 2.3 2.5 2 1 0 2 2 2 1 TLD Sel1 PF08238.12 EFC44192.1 - 4.5e-06 27.2 8.3 0.23 12.2 0.0 4.7 4 1 0 4 4 4 3 Sel1 repeat Nipped-B_C PF12830.7 EFC44192.1 - 0.017 15.1 0.0 0.11 12.4 0.2 2.2 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus TPR_1 PF00515.28 EFC44192.1 - 1.1 9.2 3.0 7.9 6.5 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DDE_3 PF13358.6 EFC44193.1 - 0.093 12.5 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease Oxidored_q6 PF01058.22 EFC44194.1 - 2.3e-18 66.3 0.1 2.8e-18 66.0 0.1 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Sel1 PF08238.12 EFC44196.1 - 2.3e-24 85.3 11.5 5.6e-06 26.9 0.2 6.5 6 1 0 6 6 6 5 Sel1 repeat TPR_8 PF13181.6 EFC44196.1 - 1.1e-06 28.3 13.9 0.21 11.9 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat LRR_6 PF13516.6 EFC44196.1 - 1.2e-06 28.1 3.3 6.5e-05 22.7 0.4 2.9 3 0 0 3 3 2 1 Leucine Rich repeat TPR_14 PF13428.6 EFC44196.1 - 1.2e-06 28.8 0.0 0.21 12.5 0.0 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44196.1 - 1.3e-05 25.6 0.7 0.61 10.6 0.2 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44196.1 - 2.9e-05 23.6 3.8 0.0022 17.6 0.5 3.2 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.17 EFC44196.1 - 4.9e-05 23.1 12.2 0.056 13.6 0.2 6.0 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44196.1 - 0.001 18.8 22.6 0.024 14.5 1.2 6.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44196.1 - 0.0048 17.2 5.2 0.29 11.5 0.1 4.5 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44196.1 - 0.0052 16.7 2.9 0.61 10.2 0.3 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44196.1 - 0.0061 17.1 1.9 5.1 7.9 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat LRR_8 PF13855.6 EFC44196.1 - 0.0064 16.2 2.1 0.037 13.8 1.0 2.3 1 1 1 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 EFC44196.1 - 0.047 14.1 4.0 0.09 13.2 0.7 2.4 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) Fis1_TPR_C PF14853.6 EFC44196.1 - 0.3 11.2 2.1 0.72 10.0 0.2 2.7 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFC44196.1 - 3.6 7.7 7.0 7.4 6.7 0.4 3.9 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EFC44196.1 - 4.1 7.4 4.6 27 4.8 0.2 3.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TTL PF03133.15 EFC44199.1 - 3.5e-53 180.7 10.4 1e-52 179.1 10.4 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFC44199.1 - 3.6e-07 29.7 0.1 0.0019 17.5 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFC44199.1 - 8.6e-06 25.2 0.0 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp zf-CCCH PF00642.24 EFC44199.1 - 0.0014 18.5 3.8 0.0031 17.4 3.8 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFC44199.1 - 0.008 16.2 8.7 0.017 15.2 8.7 1.6 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 EFC44199.1 - 0.016 15.9 0.0 0.057 14.1 0.0 1.9 1 0 0 1 1 1 0 Torus domain Dala_Dala_lig_C PF07478.13 EFC44199.1 - 0.021 14.3 0.0 0.051 13.1 0.0 1.6 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFC44199.1 - 0.036 14.1 0.0 13 5.8 0.0 2.7 2 0 0 2 2 2 0 ATP-grasp domain DIL PF01843.19 EFC44199.1 - 0.054 13.8 0.5 0.19 12.0 0.1 2.0 2 0 0 2 2 2 0 DIL domain RimK PF08443.11 EFC44199.1 - 0.067 12.8 0.0 0.17 11.5 0.0 1.6 1 0 0 1 1 1 0 RimK-like ATP-grasp domain zf-CCCH_4 PF18044.1 EFC44199.1 - 0.95 9.3 9.2 0.84 9.5 6.2 2.1 2 0 0 2 2 2 0 CCCH-type zinc finger Beta-lactamase PF00144.24 EFC44200.1 - 1.6e-34 119.6 0.0 1.3e-33 116.7 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase zf-C3HC4_3 PF13920.6 EFC44201.1 - 1.1e-14 54.0 10.5 1.7e-14 53.4 10.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC44201.1 - 2.6e-06 27.2 9.8 4.8e-06 26.3 9.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFC44201.1 - 4e-05 23.5 10.5 9.4e-05 22.3 10.5 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFC44201.1 - 0.00032 20.5 8.8 0.00096 19.0 8.9 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC44201.1 - 0.0015 18.8 12.0 0.0049 17.2 12.0 1.9 1 1 1 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 EFC44201.1 - 0.024 14.5 10.8 0.061 13.2 10.8 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC44201.1 - 0.036 13.8 6.3 1.6 8.6 1.4 2.8 2 0 0 2 2 2 0 RING-like zinc finger BBP1_C PF15272.6 EFC44201.1 - 0.062 13.1 16.7 0.03 14.2 13.6 1.8 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal Transferase PF02458.15 EFC44201.1 - 0.34 9.5 8.3 0.3 9.7 7.1 1.4 1 1 0 1 1 1 0 Transferase family Rrp44_S1 PF17215.3 EFC44201.1 - 3.6 7.6 6.5 1.7 8.6 0.2 2.3 1 1 0 2 2 2 0 S1 domain Myosin_head PF00063.21 EFC44202.1 - 2.6e-228 759.6 17.1 2e-227 756.7 17.1 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFC44202.1 - 2.6e-36 125.1 5.6 5.2e-36 124.1 5.6 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding DUF2075 PF09848.9 EFC44202.1 - 0.011 15.0 0.1 0.025 13.8 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EFC44202.1 - 0.029 14.7 0.0 0.06 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 EFC44202.1 - 0.041 13.4 1.3 5.7 6.4 0.0 2.8 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain hSac2 PF12456.8 EFC44202.1 - 0.068 12.9 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Inositol phosphatase RNA_helicase PF00910.22 EFC44202.1 - 0.075 13.4 0.0 0.35 11.3 0.0 2.3 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.6 EFC44202.1 - 0.099 12.9 0.0 0.29 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain IQ PF00612.27 EFC44202.1 - 0.17 11.7 0.9 0.38 10.7 0.9 1.6 1 0 0 1 1 1 0 IQ calmodulin-binding motif 4HBT PF03061.22 EFC44203.1 - 5.4e-06 26.7 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily RCC1_2 PF13540.6 EFC44204.1 - 6.8e-25 86.3 20.4 1e-06 28.3 0.2 5.4 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC44204.1 - 7.1e-25 87.4 15.0 2.8e-09 37.4 0.1 8.2 8 1 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat Neocarzinostat PF00960.18 EFC44204.1 - 0.0019 18.2 0.1 0.3 11.1 0.0 2.5 2 0 0 2 2 2 2 Neocarzinostatin family Exo_endo_phos PF03372.23 EFC44205.1 - 0.014 14.9 0.0 0.034 13.7 0.0 1.8 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family AMH_N PF04709.12 EFC44208.1 - 0.099 11.5 4.1 0.17 10.7 4.1 1.3 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region TMEM52 PF14979.6 EFC44208.1 - 3.9 7.4 5.3 0.71 9.8 0.2 2.3 3 0 0 3 3 3 0 Transmembrane 52 Brix PF04427.18 EFC44209.1 - 4.3e-37 128.1 0.6 6.2e-37 127.6 0.6 1.2 1 0 0 1 1 1 1 Brix domain 2OG-FeII_Oxy PF03171.20 EFC44210.1 - 0.0035 17.8 0.0 0.0056 17.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Lipase_3 PF01764.25 EFC44212.1 - 7.3e-20 71.3 0.0 1.6e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 EFC44212.1 - 0.01 15.2 0.0 0.02 14.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2048 PF09752.9 EFC44212.1 - 0.02 14.0 0.2 1 8.4 0.0 2.3 2 0 0 2 2 2 0 Abhydrolase domain containing 18 PA26 PF04636.13 EFC44212.1 - 0.054 12.4 5.6 0.11 11.4 5.6 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PAS_9 PF13426.7 EFC44212.1 - 0.12 12.7 1.0 0.34 11.2 1.0 1.8 1 0 0 1 1 1 0 PAS domain Defensin_2 PF01097.18 EFC44212.1 - 0.12 12.4 1.7 0.23 11.4 1.7 1.4 1 0 0 1 1 1 0 Arthropod defensin Pkinase PF00069.25 EFC44213.1 - 4.8e-40 137.6 0.1 5.3e-40 137.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44213.1 - 8.7e-38 130.1 0.0 9.2e-38 130.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC44213.1 - 0.0013 17.8 0.0 0.0029 16.6 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EFC44213.1 - 0.0026 17.4 0.1 1 8.9 0.0 2.1 1 1 1 2 2 2 2 Choline/ethanolamine kinase APH PF01636.23 EFC44213.1 - 0.018 15.0 0.0 0.021 14.8 0.0 1.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF4417 PF14386.6 EFC44213.1 - 0.091 12.3 0.0 0.2 11.2 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4417) RIO1 PF01163.22 EFC44213.1 - 0.097 12.3 0.0 0.15 11.7 0.0 1.3 1 1 0 1 1 1 0 RIO1 family Prismane PF03063.20 EFC44214.1 - 1.8e-147 492.2 0.1 2e-147 492.0 0.1 1.0 1 0 0 1 1 1 1 Prismane/CO dehydrogenase family DUF4116 PF13475.6 EFC44215.1 - 4e-140 455.4 70.2 1.3e-11 44.0 0.1 20.2 11 3 12 24 24 24 23 Domain of unknown function (DUF4116) DUF3523 PF12037.8 EFC44215.1 - 0.0023 17.4 0.7 0.017 14.5 0.0 2.8 5 0 0 5 5 5 1 Domain of unknown function (DUF3523) Pox_F16 PF04708.12 EFC44215.1 - 0.028 13.9 2.3 0.36 10.2 0.7 3.0 2 0 0 2 2 2 0 Poxvirus F16 protein LRR_4 PF12799.7 EFC44216.1 - 1.1e-08 35.2 57.6 0.0064 16.9 0.7 12.1 6 4 5 12 12 12 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC44216.1 - 1.6e-06 27.8 42.9 0.0044 16.7 3.8 9.8 10 2 1 11 11 11 4 Leucine rich repeat F-box-like PF12937.7 EFC44216.1 - 4.8e-05 23.2 0.2 0.00012 21.9 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC44216.1 - 0.00027 20.7 3.9 0.00034 20.4 1.1 2.6 2 0 0 2 2 2 1 F-box domain TbpB_C PF17483.2 EFC44216.1 - 0.14 12.5 3.6 20 5.6 0.1 3.9 3 1 0 3 3 3 0 C-lobe handle domain of Tf-binding protein B RSN1_7TM PF02714.15 EFC44217.1 - 1.2e-14 54.3 19.0 1.2e-14 54.3 19.0 3.2 2 2 1 4 4 4 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFC44217.1 - 0.00014 21.6 5.4 0.00014 21.6 5.4 5.0 3 2 2 6 6 6 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.22 EFC44217.1 - 0.0012 18.6 0.1 0.16 11.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UPF0172 PF03665.13 EFC44219.1 - 8.7e-42 143.3 0.0 9.8e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 EFC44219.1 - 0.0068 16.4 0.0 0.015 15.3 0.0 1.5 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SIX1_SD PF16878.5 EFC44220.1 - 0.0026 18.3 0.2 0.0035 17.8 0.2 1.5 1 1 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Ubie_methyltran PF01209.18 EFC44221.1 - 6.9e-82 274.3 0.0 9e-82 273.9 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFC44221.1 - 5e-13 49.6 0.0 1.1e-12 48.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC44221.1 - 9.8e-12 45.4 0.0 2.1e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC44221.1 - 1.3e-10 41.9 0.0 5.7e-10 39.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC44221.1 - 9.2e-10 38.5 0.0 1.7e-09 37.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC44221.1 - 6e-05 22.9 0.0 0.00012 22.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFC44221.1 - 0.0064 16.4 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_5 PF01795.19 EFC44221.1 - 0.007 15.9 0.0 0.031 13.8 0.0 1.9 1 1 1 2 2 2 1 MraW methylase family N6_N4_Mtase PF01555.18 EFC44221.1 - 0.043 13.5 0.0 0.074 12.7 0.0 1.3 1 0 0 1 1 1 0 DNA methylase Sec1 PF00995.23 EFC44222.1 - 1.6e-102 344.6 5.0 1.9e-102 344.4 5.0 1.1 1 0 0 1 1 1 1 Sec1 family Transglut_core PF01841.19 EFC44223.1 - 1.8e-11 44.5 0.0 4.9e-11 43.1 0.0 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily CENP-F_leu_zip PF10473.9 EFC44224.1 - 4.1e-05 23.6 23.5 4.1e-05 23.6 23.5 8.7 1 1 6 8 8 8 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 EFC44224.1 - 0.0093 16.1 29.5 0.0093 16.1 29.5 9.0 1 1 4 7 7 7 1 Tropomyosin like DASH_Hsk3 PF08227.11 EFC44224.1 - 0.67 10.4 10.7 9.1 6.7 0.3 5.0 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like FAD_SOX PF18371.1 EFC44224.1 - 8.6 6.8 13.8 0.18 12.2 1.0 4.5 3 0 0 3 3 3 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Lung_7-TM_R PF06814.13 EFC44225.1 - 1.4e-19 70.5 24.3 2.7e-19 69.6 24.3 1.4 1 1 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 EFC44225.1 - 3.5e-06 26.6 30.1 1.6e-05 24.5 30.1 2.1 1 1 0 1 1 1 1 Rhodopsin-like GPCR transmembrane domain Chol_subst-bind PF09129.11 EFC44225.1 - 0.037 13.0 0.0 0.064 12.2 0.0 1.3 1 0 0 1 1 1 0 Cholesterol oxidase, substrate-binding RseC_MucC PF04246.12 EFC44225.1 - 1.8 8.5 8.2 0.052 13.5 0.6 2.3 2 1 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Glyco_hydro_31 PF01055.26 EFC44226.1 - 3e-145 484.8 3.6 4e-145 484.4 2.4 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFC44226.1 - 1.8e-17 63.4 0.1 1e-16 61.0 0.0 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EFC44226.1 - 5.6e-08 33.0 0.1 1.7e-07 31.4 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) TPR_12 PF13424.6 EFC44227.1 - 4.6e-14 52.5 1.8 5.3e-06 26.6 0.1 3.4 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44227.1 - 3.8e-06 26.5 11.6 0.25 11.2 0.1 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC44227.1 - 1.4e-05 24.6 0.4 2.1e-05 24.1 0.4 1.2 1 0 0 1 1 1 1 MalT-like TPR region TPR_8 PF13181.6 EFC44227.1 - 0.00012 22.0 9.9 0.4 11.0 0.1 5.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44227.1 - 0.00016 21.5 7.0 0.78 10.0 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44227.1 - 0.0023 17.8 3.9 12 6.2 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC44227.1 - 0.0055 16.5 3.9 0.055 13.3 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF4810 PF16068.5 EFC44227.1 - 0.046 14.3 0.3 0.91 10.1 0.0 3.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) TPR_14 PF13428.6 EFC44227.1 - 0.27 12.1 0.6 9 7.4 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat NPR3 PF03666.13 EFC44228.1 - 1.1e-18 67.3 1.2 3.2e-11 42.7 0.4 4.2 3 1 0 3 3 3 3 Nitrogen Permease regulator of amino acid transport activity 3 HTH_IclR PF09339.10 EFC44228.1 - 0.0012 18.6 0.0 0.0038 17.0 0.0 1.8 2 0 0 2 2 2 1 IclR helix-turn-helix domain NPR2 PF06218.11 EFC44228.1 - 0.0032 16.3 0.2 1.1 8.0 0.1 2.4 2 0 0 2 2 2 2 Nitrogen permease regulator 2 DUF742 PF05331.11 EFC44228.1 - 0.036 13.9 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF742) UPF0122 PF04297.14 EFC44228.1 - 0.1 12.8 1.6 0.41 10.9 0.2 2.6 3 0 0 3 3 3 0 Putative helix-turn-helix protein, YlxM / p13 like MarR_2 PF12802.7 EFC44228.1 - 0.17 11.8 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 MarR family Pkinase PF00069.25 EFC44230.1 - 8.5e-76 254.8 0.7 9.6e-76 254.6 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44230.1 - 9e-45 153.0 0.1 1e-44 152.8 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC44230.1 - 2.6e-06 27.5 0.0 0.0043 17.0 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC44230.1 - 3.8e-06 26.4 0.1 7e-06 25.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC44230.1 - 0.0083 15.1 0.5 0.011 14.7 0.5 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 EFC44230.1 - 0.015 14.9 0.1 0.028 14.0 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 EFC44230.1 - 0.034 13.5 0.6 0.057 12.8 0.6 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 EFC44230.1 - 0.045 13.9 0.1 0.13 12.5 0.1 1.8 1 0 0 1 1 1 0 ABC1 family Glycos_trans_3N PF02885.17 EFC44230.1 - 0.096 12.5 0.0 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain YL1 PF05764.13 EFC44231.1 - 7.4e-05 23.0 8.2 7.4e-05 23.0 8.2 2.4 2 0 0 2 2 2 1 YL1 nuclear protein Presenilin PF01080.17 EFC44231.1 - 0.16 10.7 20.1 0.082 11.7 3.3 2.2 2 0 0 2 2 2 0 Presenilin RR_TM4-6 PF06459.12 EFC44231.1 - 2 8.2 22.3 0.35 10.6 11.2 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 EFC44231.1 - 2.9 6.1 18.2 0.19 10.0 8.7 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF3807 PF12720.7 EFC44231.1 - 5.3 7.3 24.3 1 9.6 9.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) TFIIF_alpha PF05793.12 EFC44231.1 - 5.8 5.4 30.9 0.22 10.1 14.4 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2052 PF09747.9 EFC44231.1 - 8 6.5 21.3 0.38 10.9 8.8 2.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) tRNA-synt_1d PF00750.19 EFC44232.1 - 2.4e-42 145.1 1.8 4.2e-42 144.3 1.8 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 EFC44232.1 - 1.8e-26 92.6 0.4 4.4e-26 91.4 0.4 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain tRNA-synt_1e PF01406.19 EFC44232.1 - 0.0056 16.1 0.5 0.05 12.9 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain tRNA_bind PF01588.20 EFC44232.1 - 0.072 13.2 0.0 0.18 12.0 0.0 1.7 1 0 0 1 1 1 0 Putative tRNA binding domain SAUGI PF06106.11 EFC44232.1 - 0.11 13.0 0.1 0.27 11.7 0.1 1.6 1 0 0 1 1 1 0 S. aureus uracil DNA glycosylase inhibitor DUF5074 PF16819.5 EFC44233.1 - 0.033 14.2 3.2 0.062 13.3 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5074) PQQ_3 PF13570.6 EFC44233.1 - 0.29 11.7 0.4 17 6.0 0.0 3.3 3 0 0 3 3 3 0 PQQ-like domain LSM14 PF12701.7 EFC44233.1 - 4.3 7.5 6.9 0.99 9.6 0.2 3.4 4 0 0 4 4 4 0 Scd6-like Sm domain Abhydro_lipase PF04083.16 EFC44234.1 - 2.1e-23 81.6 0.0 4.3e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFC44234.1 - 9e-16 58.3 0.4 3.9e-12 46.3 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC44234.1 - 2.5e-06 26.9 0.1 0.00037 19.9 0.0 2.5 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EFC44234.1 - 0.12 11.2 0.0 0.56 9.1 0.0 2.0 2 1 0 2 2 2 0 Chlorophyllase enzyme ACBP PF00887.19 EFC44235.1 - 5.8e-29 100.1 1.5 7e-29 99.9 1.5 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein CDT1_C PF16679.5 EFC44235.1 - 0.041 14.3 0.0 0.057 13.9 0.0 1.3 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Elong-fact-P_C PF09285.11 EFC44236.1 - 2.6e-15 55.9 0.0 6.2e-15 54.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor P, C-terminal EFP_N PF08207.12 EFC44236.1 - 0.00029 20.8 0.2 0.00063 19.7 0.2 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain RNA_pol_3_Rpc31 PF11705.8 EFC44236.1 - 0.00048 20.5 2.1 0.00048 20.5 2.1 1.4 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DTW PF03942.15 EFC44237.1 - 2.1e-28 99.4 0.2 3.6e-28 98.6 0.2 1.3 1 0 0 1 1 1 1 DTW domain zf-B_box PF00643.24 EFC44237.1 - 0.18 12.0 8.0 0.34 11.1 8.0 1.5 1 0 0 1 1 1 0 B-box zinc finger Vps26 PF03643.15 EFC44238.1 - 1.1e-33 116.4 2.3 1.4e-33 116.1 2.3 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EFC44238.1 - 1.8e-05 24.8 0.4 5.8e-05 23.2 0.4 1.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain AAA_2 PF07724.14 EFC44239.1 - 1.4e-50 171.7 0.0 2.5e-46 157.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFC44239.1 - 5.7e-31 106.5 2.1 5.7e-31 106.5 2.1 2.6 1 1 0 2 2 2 1 AAA lid domain AAA PF00004.29 EFC44239.1 - 8.5e-24 84.5 0.0 7.7e-13 49.0 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFC44239.1 - 5.4e-21 74.4 0.5 2.2e-20 72.5 0.5 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFC44239.1 - 3.7e-17 62.6 0.0 1.5e-12 47.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFC44239.1 - 3.2e-12 46.6 0.2 7.7e-06 26.0 0.0 3.3 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.6 EFC44239.1 - 1.6e-10 41.4 0.2 0.0013 19.0 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 EFC44239.1 - 2.2e-09 37.9 6.1 5.7e-05 23.6 0.4 4.3 4 2 0 5 5 3 2 AAA ATPase domain Sigma54_activat PF00158.26 EFC44239.1 - 2.7e-08 33.7 0.0 2.5e-05 24.0 0.0 2.8 2 1 0 2 2 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 EFC44239.1 - 1.7e-06 28.1 11.7 0.0041 17.0 0.0 4.9 4 2 1 5 5 5 2 ATPase domain predominantly from Archaea TniB PF05621.11 EFC44239.1 - 2.2e-06 27.2 0.1 0.00044 19.7 0.1 3.5 2 1 0 2 2 2 1 Bacterial TniB protein AAA_18 PF13238.6 EFC44239.1 - 2.3e-05 25.0 1.3 0.17 12.4 0.0 3.6 4 0 0 4 4 2 2 AAA domain AAA_7 PF12775.7 EFC44239.1 - 5.3e-05 22.8 0.1 0.075 12.5 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 EFC44239.1 - 0.00011 22.5 0.5 0.75 10.0 0.0 3.6 3 1 0 3 3 3 2 AAA domain Torsin PF06309.11 EFC44239.1 - 0.00026 21.1 0.0 0.0017 18.5 0.0 2.2 2 0 0 2 2 2 1 Torsin AAA_3 PF07726.11 EFC44239.1 - 0.00056 19.8 0.1 0.013 15.4 0.0 2.9 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFC44239.1 - 0.0009 19.0 0.0 0.032 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFC44239.1 - 0.0011 18.7 0.0 0.25 11.1 0.0 2.8 2 0 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.12 EFC44239.1 - 0.0019 18.2 0.0 0.16 11.9 0.0 3.0 2 0 0 2 2 2 1 NACHT domain ResIII PF04851.15 EFC44239.1 - 0.0026 17.8 2.9 1.2 9.1 0.0 3.8 3 1 0 4 4 3 1 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 EFC44239.1 - 0.0043 17.4 1.6 6.1 7.3 1.0 3.4 2 1 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 EFC44239.1 - 0.0043 16.5 0.0 1.8 7.9 0.0 3.3 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DNA_pol3_delta2 PF13177.6 EFC44239.1 - 0.0055 16.5 0.0 0.068 12.9 0.0 2.7 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Viral_helicase1 PF01443.18 EFC44239.1 - 0.0068 16.2 0.0 0.33 10.7 0.0 2.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 EFC44239.1 - 0.013 15.0 0.0 1.7 8.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EFC44239.1 - 0.015 14.9 0.0 3.8 7.1 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EFC44239.1 - 0.018 15.2 0.0 7.6 6.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFC44239.1 - 0.037 13.9 0.2 0.76 9.7 0.1 3.0 3 1 1 4 4 3 0 Rad17 P-loop domain DUF815 PF05673.13 EFC44239.1 - 0.061 12.5 0.6 2.4 7.2 0.2 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 EFC44239.1 - 0.083 12.2 0.0 4.2 6.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin TsaE PF02367.17 EFC44239.1 - 0.091 12.8 0.0 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 EFC44239.1 - 0.1 12.5 0.3 2.8 7.8 0.1 2.8 2 1 0 2 2 2 0 RsgA GTPase Spc42p PF11544.8 EFC44239.1 - 0.11 12.5 5.7 0.26 11.3 5.7 1.6 1 0 0 1 1 1 0 Spindle pole body component Spc42p Roc PF08477.13 EFC44239.1 - 0.11 12.7 0.0 0.99 9.6 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_6 PF12774.7 EFC44239.1 - 0.12 11.3 1.2 4.2 6.3 0.0 2.9 4 0 0 4 4 4 0 Hydrolytic ATP binding site of dynein motor region AAA_30 PF13604.6 EFC44239.1 - 0.12 12.1 0.2 5.7 6.6 0.1 3.1 2 2 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EFC44239.1 - 0.15 11.7 0.0 5.3 6.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain CbiA PF01656.23 EFC44239.1 - 0.17 12.0 0.1 1.8 8.7 0.0 2.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_19 PF13245.6 EFC44239.1 - 0.26 11.6 2.6 9.8 6.5 0.2 3.5 3 1 0 4 4 3 0 AAA domain Pinin_SDK_memA PF04696.13 EFC44239.1 - 0.35 10.9 9.9 1.8 8.6 10.3 2.0 2 0 0 2 2 1 0 pinin/SDK/memA/ protein conserved region AAA_23 PF13476.6 EFC44239.1 - 0.78 10.2 19.5 63 4.0 19.7 3.3 2 1 0 2 2 2 0 AAA domain ELMO_CED12 PF04727.13 EFC44240.1 - 6.1e-32 111.2 0.1 2.3e-31 109.3 0.1 2.0 1 0 0 1 1 1 1 ELMO/CED-12 family PX PF00787.24 EFC44240.1 - 7e-10 38.9 0.6 2e-09 37.4 0.6 1.7 1 0 0 1 1 1 1 PX domain DUF4704 PF15787.5 EFC44240.1 - 0.01 15.1 0.0 0.042 13.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4704) Polbeta PF18765.1 EFC44240.1 - 0.075 13.1 1.6 2.5 8.2 0.1 3.3 3 0 0 3 3 3 0 Polymerase beta, Nucleotidyltransferase G-alpha PF00503.20 EFC44241.1 - 5.4e-80 269.2 44.7 5.9e-79 265.8 44.7 2.2 1 1 0 1 1 1 1 G-protein alpha subunit ATG7_N PF16420.5 EFC44242.1 - 4.4e-55 187.4 3.6 6e-55 187.0 3.6 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 EFC44242.1 - 1.6e-44 152.1 0.0 2.6e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 EFC44242.1 - 0.0016 18.5 0.0 0.011 15.8 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Sec63 PF02889.16 EFC44242.1 - 0.023 13.8 0.1 0.043 13.0 0.1 1.4 1 0 0 1 1 1 0 Sec63 Brl domain 2-Hacid_dh_C PF02826.19 EFC44242.1 - 0.057 12.8 0.0 0.55 9.6 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_hydro_47 PF01532.20 EFC44243.1 - 1.1e-99 334.4 3.8 1e-98 331.3 3.8 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 DAG_kinase_N PF14513.6 EFC44243.1 - 0.24 11.6 9.1 0.45 10.7 9.1 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Macoilin PF09726.9 EFC44243.1 - 0.8 8.2 10.2 1.2 7.6 10.2 1.1 1 0 0 1 1 1 0 Macoilin family Striatin PF08232.12 EFC44243.1 - 1.1 9.9 5.9 1.7 9.2 5.9 1.2 1 0 0 1 1 1 0 Striatin family DUF1635 PF07795.11 EFC44243.1 - 1.1 9.0 8.0 1.7 8.5 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) DUF4116 PF13475.6 EFC44244.1 - 5.1e-81 266.2 30.3 6.5e-15 54.6 0.1 11.3 7 3 6 14 14 14 12 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC44244.1 - 5.7e-21 75.1 2.4 1.3e-20 73.9 1.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44244.1 - 2.1e-16 60.0 2.4 6.2e-15 55.2 0.1 2.6 1 1 1 2 2 2 2 Protein tyrosine kinase DUF2070 PF09843.9 EFC44245.1 - 1.6 6.9 10.3 2.3 6.4 10.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EVI2A PF05399.11 EFC44246.1 - 0.0047 16.6 0.3 0.0098 15.5 0.3 1.5 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) Baculo_11_kDa PF06143.11 EFC44246.1 - 0.012 15.2 3.3 0.56 9.8 0.0 2.8 3 0 0 3 3 3 0 Baculovirus 11 kDa family DUF2615 PF11027.8 EFC44246.1 - 0.025 14.7 0.0 3.4 7.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) SARAF PF06682.12 EFC44246.1 - 0.1 12.2 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis EphA2_TM PF14575.6 EFC44246.1 - 0.19 12.6 1.7 0.48 11.3 0.0 2.3 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CCDC106 PF15794.5 EFC44246.1 - 0.49 10.1 1.9 0.75 9.5 1.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF4834 PF16118.5 EFC44246.1 - 0.52 11.3 0.1 0.52 11.3 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) Pkinase_Tyr PF07714.17 EFC44247.1 - 2.3e-17 63.1 0.0 2.6e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC44247.1 - 1.6e-16 60.5 0.1 2.7e-16 59.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Peptidase_C62 PF12380.8 EFC44247.1 - 0.092 11.8 0.1 0.14 11.3 0.1 1.2 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase Big_9 PF17963.1 EFC44248.1 - 7.5e-101 331.1 242.3 1.1e-11 45.3 4.5 20.3 17 5 3 20 20 20 16 Bacterial Ig domain Cadherin_4 PF17803.1 EFC44248.1 - 5.1e-64 212.8 167.4 2.4e-09 37.7 6.6 18.1 17 1 0 17 17 17 14 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFC44248.1 - 3.6e-60 200.0 111.6 3.8e-08 33.2 0.3 17.2 12 3 4 16 16 16 14 Cadherin-like domain VWA PF00092.28 EFC44248.1 - 1.2e-21 77.7 0.2 6.3e-21 75.4 0.2 2.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC44248.1 - 7.9e-10 39.3 0.2 3.2e-09 37.4 0.2 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ras PF00071.22 EFC44249.1 - 3.6e-51 173.0 0.0 4.2e-51 172.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44249.1 - 4.4e-21 75.3 0.0 6.6e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44249.1 - 1.1e-07 31.5 0.0 1.3e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC44249.1 - 0.045 13.3 0.0 0.093 12.3 0.0 1.5 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain FA_hydroxylase PF04116.13 EFC44250.1 - 4.6e-19 69.1 17.5 4.6e-19 69.1 17.5 2.9 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily SspO PF08175.12 EFC44253.1 - 0.11 13.0 0.3 0.22 12.0 0.3 1.5 1 0 0 1 1 1 0 Small acid-soluble spore protein O family Ank_2 PF12796.7 EFC44254.1 - 4.2e-30 104.2 13.2 2e-07 31.5 0.0 7.5 3 2 5 8 8 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC44254.1 - 9.3e-18 62.5 16.9 0.019 15.5 0.4 11.1 11 1 1 12 12 11 3 Ankyrin repeat Ank_4 PF13637.6 EFC44254.1 - 7e-17 61.6 16.6 0.00095 19.7 0.0 8.9 8 1 1 9 9 9 4 Ankyrin repeats (many copies) TPR_1 PF00515.28 EFC44254.1 - 2.4e-12 46.1 1.8 0.0042 16.9 0.4 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat Ank_5 PF13857.6 EFC44254.1 - 4.5e-12 45.9 9.4 0.97 9.8 0.0 9.3 7 3 3 10 10 10 1 Ankyrin repeats (many copies) Ank PF00023.30 EFC44254.1 - 1.1e-10 41.5 22.2 0.021 15.3 0.1 9.3 8 1 0 8 8 8 3 Ankyrin repeat TPR_2 PF07719.17 EFC44254.1 - 3.3e-10 39.3 2.8 0.0034 17.4 0.4 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat zf-MYND PF01753.18 EFC44254.1 - 1.5e-08 34.5 16.1 3.8e-08 33.3 16.1 1.7 1 0 0 1 1 1 1 MYND finger TPR_17 PF13431.6 EFC44254.1 - 8.6e-07 28.9 0.4 5.6e-05 23.2 0.8 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44254.1 - 0.00077 19.1 1.6 0.0017 18.0 0.5 2.1 1 1 1 2 2 2 2 TPR repeat TPR_8 PF13181.6 EFC44254.1 - 0.0052 16.9 1.8 0.51 10.7 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44254.1 - 0.018 15.5 0.3 0.13 12.8 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44254.1 - 0.081 13.6 0.0 0.36 11.5 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC44254.1 - 0.098 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44254.1 - 0.12 12.7 0.6 0.67 10.3 0.2 2.5 1 1 0 1 1 1 0 Tetratricopeptide repeat TrpP PF17099.5 EFC44254.1 - 0.18 11.6 0.5 0.39 10.5 0.0 1.8 2 0 0 2 2 2 0 Tryptophan transporter TrpP Ras PF00071.22 EFC44255.1 - 6.6e-53 178.6 0.0 7.5e-53 178.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44255.1 - 9.6e-23 80.7 0.0 1.3e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44255.1 - 8.6e-08 31.8 0.0 1.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC44255.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Peptidase_C1 PF00112.23 EFC44256.1 - 7.9e-33 114.4 0.5 8.7e-33 114.2 0.5 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC44256.1 - 9.2e-05 21.4 0.3 0.00012 21.1 0.3 1.1 1 0 0 1 1 1 1 Peptidase C1-like family DUF4983 PF16356.5 EFC44256.1 - 0.11 13.3 0.0 0.15 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4983) SNAP PF14938.6 EFC44258.1 - 9.1e-42 143.4 11.8 6.7e-41 140.6 11.8 1.9 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 EFC44258.1 - 5.2e-06 26.1 0.5 0.25 11.4 0.0 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44258.1 - 0.00058 20.1 0.1 0.85 10.0 0.1 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44258.1 - 0.0017 18.3 6.1 0.74 10.1 0.2 4.7 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF2225 PF09986.9 EFC44258.1 - 0.0024 17.6 6.3 0.015 15.0 6.3 2.0 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 EFC44258.1 - 0.0042 17.1 7.0 1.5 9.0 0.0 4.4 3 1 1 4 4 4 2 MIT (microtubule interacting and transport) domain Spatacsin_C PF14649.6 EFC44258.1 - 0.0043 16.2 0.9 0.18 10.9 0.1 2.4 2 0 0 2 2 2 1 Spatacsin C-terminus Pex26 PF07163.12 EFC44258.1 - 0.0058 16.0 1.0 0.02 14.2 0.0 1.9 2 0 0 2 2 2 1 Pex26 protein A_deaminase PF00962.22 EFC44258.1 - 0.013 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Adenosine/AMP deaminase Foie-gras_1 PF11817.8 EFC44258.1 - 0.018 14.7 1.1 0.1 12.2 0.2 2.0 2 0 0 2 2 2 0 Foie gras liver health family 1 TPR_8 PF13181.6 EFC44258.1 - 0.024 14.8 9.3 1.9 8.9 0.3 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC44258.1 - 0.026 14.2 3.5 1.1 9.0 0.4 2.7 2 1 0 2 2 2 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 EFC44258.1 - 0.044 13.6 13.0 0.89 9.5 0.1 4.6 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44258.1 - 0.072 12.8 4.4 35 4.2 0.4 3.7 2 1 1 3 3 3 0 TPR repeat Sel1 PF08238.12 EFC44258.1 - 0.14 12.9 0.1 34 5.3 0.0 3.4 3 0 0 3 3 3 0 Sel1 repeat NSF PF02071.20 EFC44258.1 - 3.6 8.8 13.8 2.4 9.3 0.1 5.6 7 0 0 7 7 4 0 Aromatic-di-Alanine (AdAR) repeat Tubulin PF00091.25 EFC44259.1 - 7.6e-67 225.3 0.0 1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC44259.1 - 1.5e-50 170.6 0.1 2.5e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC44259.1 - 0.0023 17.7 0.0 0.0059 16.3 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 EFC44259.1 - 0.18 10.9 0.1 0.29 10.3 0.1 1.3 1 0 0 1 1 1 0 Tubulin like Ras PF00071.22 EFC44260.1 - 2.1e-21 76.2 0.0 3.4e-21 75.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44260.1 - 7.7e-21 74.5 0.0 1.3e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44260.1 - 2.5e-10 40.1 0.0 3.9e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 EFC44260.1 - 9.4e-07 28.6 0.1 2.2e-06 27.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain Gtr1_RagA PF04670.12 EFC44260.1 - 1.4e-06 27.9 0.0 2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region F-box-like PF12937.7 EFC44260.1 - 1.1e-05 25.2 0.1 2.4e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like MMR_HSR1 PF01926.23 EFC44260.1 - 0.00011 22.3 0.0 0.00026 21.0 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC44260.1 - 0.009 15.5 0.1 0.017 14.5 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DUF1508 PF07411.12 EFC44260.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1508) PWWP PF00855.17 EFC44261.1 - 4.1e-10 39.9 0.0 4.1e-10 39.9 0.0 3.3 3 1 1 4 4 4 1 PWWP domain ECH_2 PF16113.5 EFC44262.1 - 0.056 12.9 0.0 2.6 7.5 0.0 2.9 3 0 0 3 3 3 0 Enoyl-CoA hydratase/isomerase Dimer_Tnp_hAT PF05699.14 EFC44262.1 - 0.095 12.5 2.0 0.24 11.2 0.3 2.6 3 0 0 3 3 3 0 hAT family C-terminal dimerisation region AAA_19 PF13245.6 EFC44262.1 - 0.19 12.1 0.7 5.5 7.3 0.8 3.0 2 1 0 2 2 2 0 AAA domain Folate_rec PF03024.14 EFC44263.1 - 0.033 14.1 0.2 0.033 14.1 0.2 1.5 2 0 0 2 2 2 0 Folate receptor family Peptidase_M56 PF05569.11 EFC44263.1 - 0.087 12.0 0.1 0.099 11.8 0.1 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Pur_ac_phosph_N PF16656.5 EFC44264.1 - 2.5e-15 56.8 0.9 2.5e-15 56.8 0.9 2.3 3 0 0 3 3 3 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 EFC44264.1 - 2.2e-13 51.2 8.1 3.7e-13 50.4 8.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 EFC44264.1 - 6.8e-05 23.7 4.1 0.00019 22.2 0.0 3.5 3 1 1 4 4 4 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 EFC44264.1 - 0.074 13.2 0.0 3.3 7.9 0.0 2.2 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain RGS PF00615.19 EFC44267.1 - 9e-05 22.7 5.9 0.0094 16.2 5.9 2.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain PRP1_N PF06424.12 EFC44267.1 - 0.29 11.5 2.3 0.62 10.5 2.3 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF4870 PF09685.10 EFC44268.1 - 0.094 12.8 3.0 0.16 12.1 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) Sensor PF13796.6 EFC44268.1 - 0.24 11.4 6.6 0.41 10.7 6.6 1.3 1 0 0 1 1 1 0 Putative sensor TM2 PF05154.16 EFC44268.1 - 0.26 11.6 5.2 0.97 9.8 5.2 1.9 1 1 0 1 1 1 0 TM2 domain TPR_1 PF00515.28 EFC44269.1 - 1.2e-78 255.9 1.8 3.5e-09 36.1 0.1 8.9 8 1 1 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44269.1 - 5e-55 179.2 0.1 4.9e-06 26.2 0.0 8.5 8 1 1 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44269.1 - 4.7e-46 151.2 3.0 3.5e-06 26.8 0.1 8.2 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44269.1 - 2e-38 129.8 10.0 2.7e-08 33.4 0.0 10.2 6 4 5 11 11 11 5 TPR repeat TPR_17 PF13431.6 EFC44269.1 - 3e-34 114.9 9.9 3.3e-06 27.1 0.1 9.8 9 2 0 9 9 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44269.1 - 2.2e-23 82.4 0.1 0.0009 19.5 0.2 6.5 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_9 PF13371.6 EFC44269.1 - 4.9e-19 68.2 0.0 5e-05 23.4 0.0 6.8 1 1 6 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44269.1 - 1.2e-17 62.5 0.0 0.025 14.6 0.0 8.6 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44269.1 - 1.8e-16 59.6 0.1 0.54 11.0 0.0 8.4 8 1 1 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44269.1 - 4.3e-13 49.7 0.0 0.0046 17.6 0.0 5.1 3 1 2 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44269.1 - 1.7e-07 31.5 0.0 9.9 7.3 0.0 6.2 4 2 3 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC44269.1 - 6.3e-07 29.1 11.3 0.36 10.8 0.1 7.0 8 1 0 8 8 7 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC44269.1 - 6.8e-06 25.4 9.2 3.8 7.0 0.0 6.8 8 0 0 8 8 8 2 SHNi-TPR TPR_19 PF14559.6 EFC44269.1 - 3.2e-05 24.3 0.0 0.41 11.2 0.0 4.4 2 2 2 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFC44269.1 - 9.6e-05 21.7 0.0 2.5 7.2 0.0 4.2 2 1 3 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.8 EFC44269.1 - 0.00065 18.7 0.3 0.29 10.0 0.0 3.8 1 1 3 5 5 5 2 NMDA receptor-regulated protein 1 RPN7 PF10602.9 EFC44269.1 - 0.0039 16.9 1.5 0.84 9.3 0.1 3.8 2 2 3 5 5 5 1 26S proteasome subunit RPN7 Rota_NSP3 PF01665.16 EFC44269.1 - 0.028 13.5 0.3 0.82 8.7 0.0 2.5 1 1 0 2 2 2 0 Rotavirus non-structural protein NSP3 Fis1_TPR_C PF14853.6 EFC44269.1 - 0.036 14.1 0.9 7.2 6.8 0.1 4.0 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat MtrB PF05440.12 EFC44269.1 - 0.11 12.9 0.1 58 4.2 0.0 3.3 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase subunit B ANAPC3 PF12895.7 EFC44269.1 - 0.4 10.9 2.6 6.8 7.0 0.2 3.3 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Cupin_8 PF13621.6 EFC44270.1 - 4.3e-71 239.6 6.1 4.9e-71 239.4 6.1 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 EFC44270.1 - 0.015 14.8 0.7 0.05 13.1 0.2 2.0 1 1 1 2 2 2 0 Cupin superfamily protein Cupin_2 PF07883.11 EFC44270.1 - 0.064 13.0 0.1 2.9 7.7 0.0 2.6 3 0 0 3 3 3 0 Cupin domain NHL PF01436.21 EFC44272.1 - 5.5e-06 26.1 0.1 9.1e-05 22.3 0.0 3.1 4 0 0 4 4 4 1 NHL repeat SGL PF08450.12 EFC44272.1 - 0.0038 16.9 0.2 0.012 15.2 0.0 1.8 3 0 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region T4SS_CagC PF16943.5 EFC44272.1 - 0.0056 16.8 0.1 0.012 15.8 0.1 1.5 1 0 0 1 1 1 1 Cag pathogenicity island, type IV secretory system SBBP PF06739.11 EFC44272.1 - 0.0064 16.5 1.4 0.017 15.1 0.0 2.5 2 0 0 2 2 2 1 Beta-propeller repeat TMEM154 PF15102.6 EFC44272.1 - 0.015 15.2 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Cadherin_C_2 PF16492.5 EFC44272.1 - 0.018 15.8 0.1 0.05 14.4 0.1 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Peptidase_M56 PF05569.11 EFC44272.1 - 0.074 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 Tmemb_9 PF05434.11 EFC44272.1 - 0.099 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 TMEM9 ArfGap PF01412.18 EFC44273.1 - 1.9e-34 118.2 0.8 1.9e-34 118.2 0.8 2.3 2 1 0 2 2 2 1 Putative GTPase activating protein for Arf LRR_4 PF12799.7 EFC44274.1 - 5e-19 68.1 41.9 6e-06 26.5 2.5 8.3 4 3 2 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC44274.1 - 6.1e-14 51.5 36.7 0.00035 20.3 4.0 6.8 3 3 4 7 7 7 5 Leucine rich repeat LRR_6 PF13516.6 EFC44274.1 - 5.5e-10 38.5 19.3 0.42 10.8 0.1 8.5 8 0 0 8 8 8 5 Leucine Rich repeat LRR_9 PF14580.6 EFC44274.1 - 4.2e-06 26.4 15.3 8.5e-05 22.1 2.4 4.0 1 1 3 4 4 4 3 Leucine-rich repeat F-box PF00646.33 EFC44274.1 - 7e-05 22.6 0.7 0.00031 20.5 0.7 2.2 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC44274.1 - 0.00067 19.5 0.5 0.0018 18.1 0.5 1.7 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 EFC44275.1 - 2e-07 30.7 25.3 1.5e-05 24.7 0.2 5.3 4 2 0 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC44275.1 - 3.2e-06 27.4 27.2 0.0023 18.3 0.1 5.7 2 2 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC44275.1 - 2.5e-05 24.0 24.5 0.083 13.0 0.1 8.3 9 0 0 9 9 9 3 Leucine Rich repeat F-box-like PF12937.7 EFC44275.1 - 0.058 13.3 0.0 0.18 11.7 0.0 1.9 1 0 0 1 1 1 0 F-box-like Ras PF00071.22 EFC44276.1 - 3.7e-32 111.2 0.0 6.5e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44276.1 - 9.5e-25 87.1 0.0 1.9e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44276.1 - 6.5e-07 29.0 0.0 1.2e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC44276.1 - 6.6e-05 22.4 0.0 0.00014 21.3 0.0 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EFC44276.1 - 0.0013 18.5 0.0 0.0021 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFC44276.1 - 0.0015 18.6 0.0 0.0035 17.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFC44276.1 - 0.003 17.9 0.4 1.1 9.7 0.1 3.1 2 1 0 2 2 2 1 RNA helicase NB-ARC PF00931.22 EFC44276.1 - 0.0046 16.2 0.0 0.0078 15.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain PduV-EutP PF10662.9 EFC44276.1 - 0.005 16.6 0.0 0.033 13.9 0.0 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 EFC44276.1 - 0.011 16.3 0.1 0.069 13.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 EFC44276.1 - 0.012 15.4 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 EFC44276.1 - 0.016 14.4 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFC44276.1 - 0.02 15.2 0.2 0.2 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC44276.1 - 0.025 14.9 0.0 0.051 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 EFC44276.1 - 0.03 14.2 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 EFC44276.1 - 0.034 14.2 0.0 0.062 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 EFC44276.1 - 0.056 13.2 0.4 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 EFC44276.1 - 0.072 12.6 0.3 0.15 11.6 0.1 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 EFC44276.1 - 0.12 11.3 0.0 0.23 10.3 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Metallophos PF00149.28 EFC44277.1 - 9e-12 45.9 0.8 1.2e-11 45.5 0.8 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Fimbrial_CS1 PF04449.12 EFC44277.1 - 0.068 13.3 0.1 2.7 8.1 0.0 2.3 2 0 0 2 2 2 0 CS1 type fimbrial major subunit ATG27 PF09451.10 EFC44278.1 - 4.8e-05 23.4 0.0 7.9e-05 22.6 0.0 1.3 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 EFC44278.1 - 0.0033 17.5 0.2 2.6 8.1 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat DUF4141 PF13605.6 EFC44278.1 - 0.25 10.6 0.1 0.25 10.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4141) RNase_Zc3h12a PF11977.8 EFC44281.1 - 0.052 13.3 0.1 7.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Zc3h12a-like Ribonuclease NYN domain F-box PF00646.33 EFC44281.1 - 0.061 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 F-box domain DUF2576 PF10845.8 EFC44281.1 - 0.095 12.3 0.0 0.24 11.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) DUF4637 PF15470.6 EFC44281.1 - 0.89 9.3 5.0 9.3 6.0 3.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) NOA36 PF06524.12 EFC44281.1 - 1.3 8.3 7.6 2.3 7.5 7.6 1.3 1 0 0 1 1 1 0 NOA36 protein SNF2_N PF00176.23 EFC44282.1 - 4.5e-18 65.1 1.0 1e-17 63.9 1.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC44282.1 - 3e-14 53.3 0.4 3e-14 53.3 0.4 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain NUC130_3NT PF08158.12 EFC44282.1 - 0.00032 21.0 0.4 0.071 13.4 0.0 2.7 2 0 0 2 2 2 1 NUC130/3NT domain DEAD PF00270.29 EFC44282.1 - 0.00097 18.9 0.7 0.003 17.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFC44282.1 - 0.13 12.5 1.3 0.69 10.2 0.0 2.9 3 1 0 3 3 3 0 AAA domain Rrn6 PF10214.9 EFC44282.1 - 2.3 6.6 11.0 2.6 6.4 4.6 2.4 3 0 0 3 3 3 0 RNA polymerase I-specific transcription-initiation factor Arf PF00025.21 EFC44283.1 - 1.2e-76 256.0 0.4 1.4e-76 255.8 0.4 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC44283.1 - 6.3e-15 55.4 0.0 9.7e-15 54.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC44283.1 - 6e-14 52.0 0.1 7e-14 51.7 0.1 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFC44283.1 - 3.2e-12 46.3 0.0 3.9e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC44283.1 - 1.2e-11 44.4 0.4 3.2e-07 29.8 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC44283.1 - 2.1e-08 33.8 0.1 2.8e-08 33.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC44283.1 - 2.2e-07 30.9 0.1 3.4e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC44283.1 - 0.00033 20.3 0.2 0.0071 15.9 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFC44283.1 - 0.0021 17.6 2.7 0.01 15.3 2.7 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B PduV-EutP PF10662.9 EFC44283.1 - 0.0043 16.8 0.2 0.73 9.6 0.0 2.2 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation MeaB PF03308.16 EFC44283.1 - 0.011 14.7 0.3 0.051 12.5 0.2 2.0 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EFC44283.1 - 0.062 13.8 0.0 0.093 13.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain Antistasin PF02822.14 EFC44285.1 - 0.0082 16.8 10.0 0.0082 16.8 10.0 25.1 23 5 0 23 23 23 12 Antistasin family Pkinase PF00069.25 EFC44286.1 - 4.7e-60 203.2 0.0 1.4e-59 201.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44286.1 - 1.4e-27 96.6 0.2 7.2e-20 71.4 0.1 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFC44286.1 - 1.6e-07 31.0 0.1 0.011 15.1 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 EFC44286.1 - 2.7e-05 23.3 0.0 3.8e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC44286.1 - 0.00095 18.6 0.0 0.0026 17.2 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC44286.1 - 0.004 17.1 0.4 0.26 11.2 0.3 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFC44286.1 - 0.088 12.4 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family DUF4506 PF14958.6 EFC44288.1 - 1.9e-06 27.4 0.3 3.7e-06 26.5 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4506) DUF4800 PF16057.5 EFC44288.1 - 0.0078 15.5 0.2 0.018 14.3 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) TPH PF13868.6 EFC44289.1 - 2.3e-70 236.9 149.7 2.3e-70 236.9 149.7 2.2 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain WD40 PF00400.32 EFC44290.1 - 5.4e-17 61.9 5.7 5.3e-06 27.1 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC44290.1 - 1.8e-06 28.2 2.1 0.36 11.2 0.0 5.0 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain CAF1C_H4-bd PF12265.8 EFC44290.1 - 7.1e-06 26.2 0.3 0.00012 22.3 0.1 2.8 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex FAD_binding_1 PF00667.20 EFC44291.1 - 3.8e-38 131.3 0.0 6.4e-38 130.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFC44291.1 - 1.8e-22 80.1 0.1 3.9e-22 79.0 0.1 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 EFC44291.1 - 3.4e-10 40.5 0.0 1.2e-09 38.8 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Pkinase_Tyr PF07714.17 EFC44292.1 - 7.4e-14 51.6 0.7 2.9e-13 49.7 0.7 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC44292.1 - 1.2e-13 51.0 2.4 1.2e-13 51.0 2.4 2.0 2 1 0 2 2 2 1 Protein kinase domain TPR_17 PF13431.6 EFC44292.1 - 0.0017 18.6 2.4 2.1 8.9 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44292.1 - 0.0017 18.6 7.8 0.049 13.9 0.3 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44292.1 - 0.0019 18.8 0.4 0.17 12.6 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Pkinase_fungal PF17667.1 EFC44292.1 - 0.0021 16.9 0.5 0.0057 15.5 0.5 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC44292.1 - 0.0037 16.7 0.1 0.0081 15.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_2 PF07719.17 EFC44292.1 - 0.022 14.8 0.7 13 6.2 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Aminotran_1_2 PF00155.21 EFC44293.1 - 4.2e-53 180.8 0.0 5e-53 180.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFC44293.1 - 7.7e-05 22.1 0.0 0.00012 21.5 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.20 EFC44293.1 - 0.00021 20.2 0.0 0.00034 19.5 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 EFC44293.1 - 0.00039 19.1 0.0 0.001 17.7 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFC44293.1 - 0.0081 15.2 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Ion_trans PF00520.31 EFC44294.1 - 5.9e-21 74.8 23.9 5.9e-21 74.8 23.9 1.5 2 0 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.16 EFC44294.1 - 2.9e-11 43.2 7.6 2.9e-11 43.2 7.6 2.5 3 1 0 3 3 3 1 Ion channel Claudin_2 PF13903.6 EFC44294.1 - 0.0017 18.1 0.4 0.0017 18.1 0.4 2.7 2 1 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction Pan3_PK PF18101.1 EFC44294.1 - 0.097 12.6 0.3 0.18 11.8 0.3 1.4 1 0 0 1 1 1 0 Pan3 Pseudokinase domain Lig_chan PF00060.26 EFC44294.1 - 0.1 12.4 0.2 0.1 12.4 0.2 1.9 2 0 0 2 2 2 0 Ligand-gated ion channel DUF2207 PF09972.9 EFC44294.1 - 0.86 8.3 7.0 0.36 9.5 0.2 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Ribosomal_S8e PF01201.22 EFC44295.1 - 3e-48 163.5 3.4 3.6e-48 163.2 3.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e 4PPT_N PF17837.1 EFC44295.1 - 0.26 11.5 1.9 0.33 11.1 0.5 1.9 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain zf-CHCC PF10276.9 EFC44296.1 - 1e-11 44.6 1.3 1.6e-11 44.0 1.3 1.3 1 0 0 1 1 1 1 Zinc-finger domain Glyco_hydro_3 PF00933.21 EFC44297.1 - 0.0013 18.2 0.0 0.0015 18.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain NHL PF01436.21 EFC44298.1 - 1.7e-06 27.7 0.1 0.12 12.4 0.0 4.2 4 0 0 4 4 4 2 NHL repeat G-alpha PF00503.20 EFC44299.1 - 3.1e-48 164.7 18.3 4.5e-48 164.2 18.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC44299.1 - 9.1e-07 28.5 1.3 0.012 15.1 1.2 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family T2SSE PF00437.20 EFC44299.1 - 0.0009 18.4 0.5 0.004 16.3 0.0 2.1 2 1 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EFC44299.1 - 0.0011 19.1 0.1 0.037 14.1 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC44299.1 - 0.0023 17.8 5.6 0.0035 17.3 0.2 2.7 2 1 1 3 3 3 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 EFC44299.1 - 0.0058 16.0 0.0 0.015 14.7 0.0 1.7 1 0 0 1 1 1 1 FtsK/SpoIIIE family CobU PF02283.16 EFC44299.1 - 0.0062 16.1 0.3 0.026 14.1 0.0 2.2 2 0 0 2 2 2 1 Cobinamide kinase / cobinamide phosphate guanyltransferase DUF4874 PF16173.5 EFC44299.1 - 0.021 14.5 2.2 0.23 11.1 0.5 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4874) GTP_EFTU PF00009.27 EFC44299.1 - 0.022 14.3 0.9 0.14 11.7 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EFC44299.1 - 0.036 13.6 0.3 0.13 11.7 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 EFC44299.1 - 0.054 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF357 PF04010.13 EFC44299.1 - 0.077 13.1 0.1 23 5.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF357) DUF664 PF04978.12 EFC44299.1 - 0.13 12.7 0.0 0.31 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF664) ATP_bind_1 PF03029.17 EFC44299.1 - 0.23 11.2 4.5 1.4 8.7 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EFC44299.1 - 0.36 11.3 4.2 1.8 9.1 4.1 2.4 1 1 0 1 1 1 0 ABC transporter P16-Arc PF04699.14 EFC44301.1 - 0.042 14.3 0.1 0.042 14.3 0.1 1.6 2 0 0 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) BRD4_CDT PF17105.5 EFC44301.1 - 6.2 6.5 11.1 30 4.3 5.4 3.2 2 1 1 3 3 3 0 C-terminal domain of bromodomain protein 4 REJ PF02010.15 EFC44302.1 - 3.7e-39 134.8 9.0 3.7e-39 134.8 9.0 4.4 3 1 0 4 4 4 2 REJ domain EGF_2 PF07974.13 EFC44302.1 - 3e-14 53.1 136.4 0.0012 19.2 7.5 10.5 10 1 0 10 10 10 7 EGF-like domain EGF PF00008.27 EFC44302.1 - 0.00062 20.0 1.1 0.00062 20.0 1.1 8.7 9 1 0 9 9 9 4 EGF-like domain Laminin_EGF PF00053.24 EFC44302.1 - 0.0009 19.3 121.6 0.026 14.7 17.6 7.7 2 2 5 7 7 7 3 Laminin EGF domain DUF5093 PF17011.5 EFC44303.1 - 0.0083 16.4 0.1 0.021 15.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5093) DUF2205 PF10224.9 EFC44304.1 - 0.0016 18.4 16.7 0.045 13.7 4.0 3.3 2 1 1 3 3 3 2 Short coiled-coil protein Baculo_F PF12259.8 EFC44304.1 - 0.0038 15.8 14.0 0.0045 15.6 14.0 1.1 1 0 0 1 1 1 1 Baculovirus F protein Spc7 PF08317.11 EFC44304.1 - 0.0054 15.7 13.3 0.0054 15.7 13.3 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein ADIP PF11559.8 EFC44304.1 - 0.0063 16.6 23.2 0.022 14.9 5.7 2.2 1 1 0 2 2 2 2 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 EFC44304.1 - 0.01 16.1 6.6 0.01 16.1 6.6 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 EFC44304.1 - 0.011 16.4 12.6 0.032 14.8 2.3 2.8 2 1 0 2 2 2 0 SlyX Fez1 PF06818.15 EFC44304.1 - 0.013 15.9 19.6 0.16 12.4 7.4 2.1 1 1 1 2 2 2 0 Fez1 AAA_13 PF13166.6 EFC44304.1 - 0.023 13.3 17.0 0.028 13.1 16.5 1.3 1 1 0 1 1 1 0 AAA domain CENP-H PF05837.12 EFC44304.1 - 0.045 14.1 18.7 0.048 14.1 8.6 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF2570 PF10828.8 EFC44304.1 - 0.063 13.1 16.3 0.082 12.7 4.7 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2570) KLRAQ PF10205.9 EFC44304.1 - 0.065 13.5 21.0 0.3 11.4 7.6 2.9 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein GAS PF13851.6 EFC44304.1 - 0.071 12.5 27.5 1.2 8.4 4.2 3.0 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 EFC44304.1 - 0.24 11.5 23.1 0.48 10.5 6.7 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein HAUS-augmin3 PF14932.6 EFC44304.1 - 0.26 10.8 18.0 0.26 10.9 3.5 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 TMPIT PF07851.13 EFC44304.1 - 0.34 10.1 20.7 0.94 8.7 6.3 2.1 1 1 0 2 2 2 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 EFC44304.1 - 0.43 10.8 17.0 1.1 9.6 3.6 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 EFC44304.1 - 0.62 10.2 17.6 1.1 9.3 3.4 2.8 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Tmemb_cc2 PF10267.9 EFC44304.1 - 0.64 9.1 25.2 1.9 7.5 24.4 1.7 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein APG6_N PF17675.1 EFC44304.1 - 0.7 10.4 25.6 0.42 11.1 8.8 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region TMF_DNA_bd PF12329.8 EFC44304.1 - 0.79 9.8 19.1 0.62 10.1 6.1 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CC2-LZ PF16516.5 EFC44304.1 - 0.93 9.9 17.3 0.066 13.6 5.4 2.9 1 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator IFT57 PF10498.9 EFC44304.1 - 1 8.3 24.8 1.4 7.8 6.1 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 ZapB PF06005.12 EFC44304.1 - 1.3 9.6 23.9 0.13 12.7 7.5 3.1 2 2 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 EFC44304.1 - 1.3 9.7 22.2 0.11 13.2 5.3 2.5 1 1 1 2 2 2 0 Initiation control protein YabA SKA2 PF16740.5 EFC44304.1 - 1.3 8.8 14.3 2.1 8.2 3.4 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 BRE1 PF08647.11 EFC44304.1 - 1.4 9.1 25.4 0.79 9.8 6.9 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase JIP_LZII PF16471.5 EFC44304.1 - 1.4 9.1 19.1 0.97 9.6 0.4 3.5 3 2 0 3 3 3 0 JNK-interacting protein leucine zipper II DivIC PF04977.15 EFC44304.1 - 1.4 8.7 25.4 0.41 10.4 4.4 4.4 2 2 2 4 4 4 0 Septum formation initiator DUF4795 PF16043.5 EFC44304.1 - 1.7 8.2 21.9 0.11 12.1 7.3 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) CLZ PF16526.5 EFC44304.1 - 1.8 9.0 11.7 1.4 9.3 0.7 2.8 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 EFC44304.1 - 1.8 8.6 16.4 1.1 9.3 0.4 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) PRKG1_interact PF15898.5 EFC44304.1 - 1.9 9.5 22.4 4.6 8.2 8.4 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Rootletin PF15035.6 EFC44304.1 - 2.2 8.3 23.9 0.43 10.6 7.1 2.5 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DASH_Dad3 PF08656.10 EFC44304.1 - 2.5 8.3 9.6 5 7.3 1.9 2.7 2 1 0 2 2 2 0 DASH complex subunit Dad3 Flg_bbr_C PF06429.13 EFC44304.1 - 2.6 8.2 6.8 0.78 9.9 1.4 2.8 3 1 0 3 3 3 0 Flagellar basal body rod FlgEFG protein C-terminal DUF948 PF06103.11 EFC44304.1 - 2.8 8.2 4.9 3.1 8.1 0.5 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4337 PF14235.6 EFC44304.1 - 3.7 7.7 12.9 0.32 11.1 1.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4337) Atg14 PF10186.9 EFC44304.1 - 3.9 6.5 20.0 6.7 5.7 8.2 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5082 PF16888.5 EFC44304.1 - 5.1 7.4 22.1 1.5 9.1 16.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) GrpE PF01025.19 EFC44304.1 - 7.1 6.3 19.0 1.6 8.4 7.6 2.6 1 1 1 2 2 2 0 GrpE NPV_P10 PF05531.12 EFC44304.1 - 7.1 7.2 8.6 22 5.6 1.2 2.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Prominin PF05478.11 EFC44304.1 - 7.8 4.3 18.7 69 1.2 18.8 1.8 1 1 0 1 1 1 0 Prominin RasGAP_C PF03836.15 EFC44304.1 - 9.8 6.3 24.1 3.4 7.8 3.0 2.5 1 1 1 2 2 2 0 RasGAP C-terminus Kinesin PF00225.23 EFC44305.1 - 3e-107 358.4 0.1 3e-107 358.4 0.1 2.2 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC44305.1 - 9.9e-24 84.0 0.0 9.9e-24 84.0 0.0 3.0 3 0 0 3 3 3 1 Microtubule binding Kinesin_assoc PF16183.5 EFC44305.1 - 1.4e-18 67.7 10.8 1.1e-12 48.5 0.0 3.8 2 1 1 3 3 3 2 Kinesin-associated FHA PF00498.26 EFC44305.1 - 5.9e-10 39.4 0.2 1.7e-09 37.9 0.2 1.9 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 EFC44305.1 - 2.3e-05 24.6 0.0 7.3e-05 23.0 0.0 1.8 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain C2-C2_1 PF11618.8 EFC44305.1 - 0.006 16.7 0.1 0.047 13.8 0.0 2.3 2 0 0 2 2 2 1 First C2 domain of RPGR-interacting protein 1 DUF3800 PF12686.7 EFC44305.1 - 0.33 11.6 4.5 3.2 8.4 3.3 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) TcdA_TcdB PF12919.7 EFC44305.1 - 0.43 9.8 20.7 0.35 10.1 2.1 2.8 3 0 0 3 3 3 0 TcdA/TcdB catalytic glycosyltransferase domain AAA_11 PF13086.6 EFC44305.1 - 0.93 9.2 18.9 0.77 9.5 2.4 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 EFC44305.1 - 0.98 9.5 16.7 0.44 10.6 3.2 3.7 3 0 0 3 3 3 0 Helicase HerA, central domain LUC7 PF03194.15 EFC44305.1 - 1.3 8.6 18.0 0.92 9.1 9.2 2.4 2 0 0 2 2 2 0 LUC7 N_terminus RdRP PF05183.12 EFC44306.1 - 1.2e-60 205.8 0.3 9.3e-45 153.3 0.2 2.3 1 1 1 2 2 2 2 RNA dependent RNA polymerase SPRY PF00622.28 EFC44307.1 - 7.3e-07 29.3 0.3 1.4e-06 28.5 0.3 1.4 1 0 0 1 1 1 1 SPRY domain F-box-like PF12937.7 EFC44307.1 - 0.013 15.4 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 F-box-like DSPc PF00782.20 EFC44308.1 - 4.4e-08 33.0 0.0 1.2e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC44308.1 - 0.0051 16.4 0.0 0.0084 15.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ribosomal_L24e PF01246.20 EFC44309.1 - 1.5e-25 89.2 0.2 1.5e-25 89.2 0.2 2.1 2 1 0 2 2 2 1 Ribosomal protein L24e DUF1676 PF07898.13 EFC44309.1 - 0.51 10.4 6.4 0.6 10.1 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DDHD PF02862.17 EFC44309.1 - 1.9 8.6 9.3 2.5 8.2 9.3 1.1 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EFC44309.1 - 2.6 6.7 8.6 2.9 6.6 8.6 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 EFC44309.1 - 9 5.0 9.7 10 4.9 9.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter TPR_MLP1_2 PF07926.12 EFC44310.1 - 0.057 13.5 6.3 0.098 12.7 6.3 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein GrpE PF01025.19 EFC44310.1 - 0.95 9.1 8.0 1.1 8.9 4.7 2.1 1 1 1 2 2 2 0 GrpE CH PF00307.31 EFC44312.1 - 2.2e-09 37.4 0.2 8.5e-09 35.6 0.2 2.0 1 0 0 1 1 1 1 Calponin homology (CH) domain SlyX PF04102.12 EFC44312.1 - 0.0087 16.7 4.9 0.0087 16.7 4.9 3.5 2 2 0 2 2 2 1 SlyX CRAL_TRIO PF00650.20 EFC44313.1 - 2.6e-23 82.5 0.2 3.9e-23 81.9 0.2 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC44313.1 - 0.033 14.4 0.3 0.11 12.7 0.3 2.0 1 1 0 1 1 1 0 CRAL/TRIO, N-terminal domain Cas6b_N PF17955.1 EFC44313.1 - 0.041 14.0 0.1 0.083 13.0 0.1 1.5 1 0 0 1 1 1 0 Cas6b N-terminal domain CHZ PF09649.10 EFC44315.1 - 7.2e-05 22.2 0.4 0.0002 20.7 0.4 1.8 1 0 0 1 1 1 1 Histone chaperone domain CHZ Myc_N PF01056.18 EFC44315.1 - 0.44 10.4 11.5 0.46 10.3 11.5 1.0 1 0 0 1 1 1 0 Myc amino-terminal region UCH PF00443.29 EFC44316.1 - 1.6e-57 194.9 1.2 1.9e-57 194.7 1.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC44316.1 - 1.2e-23 84.2 2.7 1.6e-23 83.8 2.7 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 EFC44316.1 - 0.014 14.9 3.5 0.55 9.6 0.4 3.6 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Headcase PF16002.5 EFC44316.1 - 0.027 13.9 1.8 0.032 13.7 0.7 1.6 2 0 0 2 2 2 0 Headcase protein zf-RING_6 PF14835.6 EFC44316.1 - 0.044 13.7 0.3 0.11 12.3 0.3 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Aminotran_1_2 PF00155.21 EFC44317.1 - 3.1e-71 240.4 0.0 3.7e-71 240.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFC44317.1 - 1.3e-05 24.4 0.0 3.2e-05 23.0 0.0 1.6 1 1 1 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 EFC44317.1 - 0.00011 20.8 0.0 0.00018 20.2 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Radical_SAM PF04055.21 EFC44317.1 - 0.0019 18.6 0.1 0.47 10.8 0.1 2.6 1 1 0 1 1 1 1 Radical SAM superfamily Beta_elim_lyase PF01212.21 EFC44317.1 - 0.0038 16.5 0.0 0.0059 15.9 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 EFC44317.1 - 0.018 13.6 0.0 0.032 12.8 0.0 1.4 1 0 0 1 1 1 0 Methionine gamma-lyase HATPase_c_5 PF14501.6 EFC44317.1 - 0.029 14.3 0.1 0.062 13.2 0.1 1.5 1 0 0 1 1 1 0 GHKL domain DegT_DnrJ_EryC1 PF01041.17 EFC44317.1 - 0.075 12.3 0.1 0.18 11.1 0.1 1.6 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family zf-CRD PF17979.1 EFC44319.1 - 0.07 13.2 5.6 0.088 12.9 5.1 1.5 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Tubulin_C PF03953.17 EFC44320.1 - 2.5e-49 166.6 0.1 3.2e-49 166.3 0.1 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Trypan_PARP PF05887.11 EFC44321.1 - 2.1e-06 27.8 75.6 0.0022 18.0 37.5 2.2 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) LRR_6 PF13516.6 EFC44322.1 - 1.5e-27 93.3 16.7 0.00012 21.8 0.2 9.5 9 0 0 9 9 9 8 Leucine Rich repeat LRR_8 PF13855.6 EFC44322.1 - 1.4e-25 88.8 44.4 7e-07 28.9 2.1 4.6 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC44322.1 - 1.1e-17 63.8 22.3 0.0052 17.2 0.8 6.6 1 1 4 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC44322.1 - 2.7e-08 33.2 17.0 0.23 12.1 0.2 9.1 9 2 0 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC44322.1 - 0.052 13.0 13.0 0.52 9.8 4.7 3.1 1 1 1 3 3 3 0 Leucine-rich repeat EGF_2 PF07974.13 EFC44323.1 - 2.2e-06 27.9 58.3 0.0029 18.0 6.7 6.4 6 0 0 6 6 6 4 EGF-like domain RGS PF00615.19 EFC44324.1 - 6.3e-06 26.5 10.7 6.3e-06 26.5 10.7 2.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain Marek_A PF02124.15 EFC44324.1 - 0.11 12.3 0.6 0.21 11.4 0.6 1.4 1 0 0 1 1 1 0 Marek's disease glycoprotein A FtsX PF02687.21 EFC44327.1 - 0.0062 17.0 1.0 4.1 7.9 0.0 2.2 2 0 0 2 2 2 2 FtsX-like permease family Sigma_reg_N PF13800.6 EFC44327.1 - 0.75 10.1 3.3 4.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Hemerythrin PF01814.23 EFC44328.1 - 5.2e-11 43.3 0.0 1.1e-10 42.2 0.0 1.6 1 1 0 2 2 2 1 Hemerythrin HHE cation binding domain CH PF00307.31 EFC44329.1 - 1.6e-32 111.9 8.3 7.8e-20 71.1 0.6 2.5 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFC44329.1 - 6.9e-06 25.8 0.1 0.063 13.1 0.0 2.7 2 0 0 2 2 2 2 CAMSAP CH domain VWD PF00094.25 EFC44330.1 - 7.8e-08 32.7 0.1 2.6e-07 31.0 0.1 1.9 1 0 0 1 1 1 1 von Willebrand factor type D domain DUF1805 PF08827.11 EFC44330.1 - 0.019 15.3 0.9 0.019 15.3 0.9 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1805) Tli4_N PF18443.1 EFC44330.1 - 1.5 9.2 0.0 1.5 9.2 0.0 5.1 2 1 3 5 5 5 0 Tle cognate immunity protein 4 N-terminal domain Acetyltransf_10 PF13673.7 EFC44332.1 - 1e-12 48.1 0.0 1.5e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC44332.1 - 9.4e-12 45.2 0.1 1.3e-11 44.7 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC44332.1 - 1.3e-11 44.7 0.2 2e-11 44.1 0.2 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC44332.1 - 6.6e-09 35.6 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFC44332.1 - 1e-05 25.5 0.0 2.7e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 EFC44332.1 - 1.5e-05 25.0 0.0 3.1e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC44332.1 - 0.029 13.9 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 Putative acetyl-transferase RGS PF00615.19 EFC44333.1 - 0.0091 16.3 4.5 0.031 14.5 4.5 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain BSD PF03909.17 EFC44333.1 - 0.023 14.7 1.6 0.27 11.2 0.1 2.6 1 1 1 2 2 2 0 BSD domain FKBP_C PF00254.28 EFC44334.1 - 9.6e-34 115.6 0.0 1.1e-33 115.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N_2 PF18023.1 EFC44334.1 - 0.15 12.2 0.0 0.77 9.9 0.0 1.9 1 1 0 1 1 1 0 BDBT FKBP like N-terminal FSA_C PF10479.9 EFC44335.1 - 0.51 8.4 4.1 0.6 8.2 4.1 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mem_trans PF03547.18 EFC44336.1 - 0.033 12.6 0.3 0.052 12.0 0.3 1.2 1 0 0 1 1 1 0 Membrane transport protein Peptidase_M54 PF07998.11 EFC44337.1 - 1.5e-12 47.9 0.7 2.3e-12 47.3 0.7 1.3 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_3 PF13582.6 EFC44337.1 - 0.13 12.8 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PQ-loop PF04193.14 EFC44339.1 - 3.1e-22 78.1 20.0 5.3e-13 48.5 1.0 3.4 4 0 0 4 4 4 2 PQ loop repeat QueT PF06177.11 EFC44339.1 - 0.69 10.3 8.1 0.13 12.7 0.4 2.9 2 2 1 3 3 3 0 QueT transporter Sel1 PF08238.12 EFC44340.1 - 1.2e-43 146.5 18.5 3.3e-09 37.1 0.1 7.2 7 0 0 7 7 7 7 Sel1 repeat TPR_14 PF13428.6 EFC44340.1 - 0.0048 17.6 6.4 7 7.8 0.0 5.0 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44340.1 - 0.012 16.1 2.9 13 6.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 EFC44340.1 - 0.024 15.0 1.1 5.2 7.5 0.1 3.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44340.1 - 0.033 14.5 4.9 6.4 7.1 0.0 5.1 3 2 2 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC44340.1 - 0.57 10.4 6.3 1.7 8.9 0.2 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 HPS3_N PF14761.6 EFC44341.1 - 0.0037 16.8 0.6 0.48 9.9 0.3 2.1 1 1 0 2 2 2 2 Hermansky-Pudlak syndrome 3 DUF4954 PF16314.5 EFC44341.1 - 0.02 13.1 0.3 0.024 12.8 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Arm-DNA-bind_5 PF17293.2 EFC44342.1 - 0.14 12.6 0.6 0.37 11.3 0.1 1.9 2 0 0 2 2 2 0 Arm DNA-binding domain GST_N_3 PF13417.6 EFC44343.1 - 4.6e-08 33.3 0.0 8.1e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFC44343.1 - 2.1e-06 28.0 0.0 5.8e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC44343.1 - 2.4e-06 27.7 0.0 5.4e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC44343.1 - 0.0002 21.5 0.0 0.00043 20.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC44343.1 - 0.00025 21.3 0.0 0.00052 20.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC44343.1 - 0.0056 16.7 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain RCC1 PF00415.18 EFC44344.1 - 1.1e-10 42.0 0.3 7.3e-05 23.3 0.0 4.2 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC44344.1 - 0.00061 19.5 5.5 0.079 12.8 0.7 3.8 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Ephrin_rec_like PF07699.13 EFC44345.1 - 0.15 11.9 16.8 1.1 9.1 5.5 2.6 1 1 1 2 2 2 0 Putative ephrin-receptor like Glft2_N PF17994.1 EFC44346.1 - 0.082 12.8 0.2 4.4 7.2 0.0 3.1 2 0 0 2 2 2 0 Galactofuranosyltransferase 2 N-terminal SLC35F PF06027.12 EFC44348.1 - 1.1e-82 277.9 21.5 1.3e-82 277.7 21.5 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 EFC44348.1 - 5.5e-10 39.6 31.9 4.1e-05 23.8 11.2 2.2 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EFC44348.1 - 2.6e-05 23.3 4.3 2.6e-05 23.3 4.3 2.1 1 1 1 2 2 2 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EFC44348.1 - 0.011 15.0 19.4 0.06 12.5 19.4 2.1 1 1 0 1 1 1 0 UAA transporter family Mg_trans_NIPA PF05653.14 EFC44348.1 - 0.011 14.8 7.0 0.025 13.7 7.0 1.8 1 1 0 1 1 1 0 Magnesium transporter NIPA MotA_ExbB PF01618.16 EFC44348.1 - 0.13 12.0 0.1 0.41 10.4 0.0 1.8 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family Peptidase_S8 PF00082.22 EFC44349.1 - 2.6e-39 135.3 0.0 4.3e-39 134.5 0.0 1.4 1 0 0 1 1 1 1 Subtilase family PAT1 PF09770.9 EFC44350.1 - 1.5 7.0 16.2 1.9 6.7 16.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EF-hand_7 PF13499.6 EFC44351.1 - 4.2e-13 49.5 10.0 1.7e-09 38.0 0.5 3.3 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC44351.1 - 6.4e-12 44.1 13.2 1.3e-05 24.3 1.2 4.3 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC44351.1 - 9.4e-11 40.8 4.6 0.0011 18.8 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EFC44351.1 - 1.5e-07 31.2 4.3 1.1e-06 28.4 1.4 3.5 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 EFC44351.1 - 3.5e-05 23.1 5.0 0.0003 20.2 0.5 3.3 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 EFC44351.1 - 0.02 15.2 0.0 0.073 13.4 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain TIP49 PF06068.13 EFC44352.1 - 3.1e-154 513.4 3.9 4.5e-154 512.9 3.9 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFC44352.1 - 1.6e-24 85.8 0.9 6.1e-24 83.9 0.2 2.5 3 0 0 3 3 2 1 TIP49 AAA-lid domain AAA PF00004.29 EFC44352.1 - 5.8e-08 33.2 4.3 3.5e-05 24.2 0.1 3.3 3 1 1 4 4 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFC44352.1 - 3.4e-07 30.2 0.2 0.0004 20.2 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 EFC44352.1 - 9.6e-07 28.4 0.3 2e-06 27.3 0.3 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 EFC44352.1 - 7.4e-05 23.2 0.1 0.00035 21.0 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC44352.1 - 9e-05 22.8 0.3 0.46 10.7 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFC44352.1 - 9.7e-05 22.4 0.1 0.036 14.0 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFC44352.1 - 0.00011 21.7 1.1 0.002 17.5 0.4 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 EFC44352.1 - 0.00011 22.6 2.2 0.0032 17.8 2.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFC44352.1 - 0.0013 18.4 0.0 0.0044 16.6 0.1 1.8 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EFC44352.1 - 0.0028 17.4 0.2 1.5 8.5 0.1 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain DNA_pol3_delta PF06144.13 EFC44352.1 - 0.005 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Zeta_toxin PF06414.12 EFC44352.1 - 0.019 14.3 0.2 0.051 12.8 0.2 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 EFC44352.1 - 0.038 14.5 2.7 0.049 14.1 0.4 2.2 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EFC44352.1 - 0.05 13.6 0.8 9.6 6.2 0.1 2.6 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit AAA_11 PF13086.6 EFC44352.1 - 0.068 12.9 2.7 0.45 10.2 2.6 2.2 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 EFC44352.1 - 0.084 12.1 0.2 0.29 10.3 0.0 1.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 EFC44352.1 - 0.098 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EFC44352.1 - 0.11 13.0 0.1 0.41 11.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EFC44352.1 - 0.23 11.0 2.0 0.8 9.2 0.0 2.7 3 1 1 4 4 4 0 P-loop containing dynein motor region Glyco_hydro_38N PF01074.22 EFC44353.1 - 3.6e-79 266.1 0.1 6.1e-79 265.4 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 EFC44353.1 - 5.4e-49 167.2 0.0 9.7e-49 166.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 EFC44353.1 - 2.3e-25 88.5 0.0 5.2e-25 87.4 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain LSM14 PF12701.7 EFC44354.1 - 8.5e-31 105.9 0.0 1.4e-30 105.2 0.0 1.4 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 EFC44354.1 - 2.1e-07 31.0 0.2 5.6e-07 29.6 0.0 1.8 2 0 0 2 2 2 1 Ataxin 2 SM domain FDF PF09532.10 EFC44354.1 - 0.037 14.9 2.3 0.037 14.9 2.3 2.7 2 2 1 3 3 3 0 FDF domain LSM PF01423.22 EFC44355.1 - 3.5e-19 68.2 0.2 6.3e-19 67.4 0.2 1.4 2 0 0 2 2 2 1 LSM domain SM-ATX PF14438.6 EFC44355.1 - 0.00019 21.5 0.1 0.00028 20.9 0.1 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain BPL_C PF02237.17 EFC44355.1 - 0.017 15.0 0.2 0.032 14.1 0.2 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Zn_clus PF00172.18 EFC44356.1 - 4.2e-07 30.0 11.4 9.2e-07 28.9 11.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 EFC44356.1 - 0.85 8.1 23.4 0.49 8.9 18.6 2.1 2 0 0 2 2 2 0 Macoilin family OTU PF02338.19 EFC44357.1 - 7.3e-14 52.3 0.0 1.8e-13 51.1 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFC44357.1 - 3.4e-06 26.7 0.6 0.00029 20.4 0.0 2.5 1 1 1 2 2 2 2 Peptidase C65 Otubain Pkinase PF00069.25 EFC44358.1 - 4.1e-30 105.0 0.0 4.3e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44358.1 - 1.8e-19 70.0 0.0 2.1e-19 69.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44358.1 - 1.1e-08 34.4 0.0 1.2e-08 34.1 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC44358.1 - 4.1e-06 26.3 0.0 4.6e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EFC44358.1 - 0.014 14.9 0.0 0.017 14.7 0.0 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 EFC44358.1 - 0.046 13.6 0.0 0.055 13.4 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFC44358.1 - 0.049 12.6 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase CoA_transf_3 PF02515.17 EFC44359.1 - 5e-113 378.0 0.0 5.6e-113 377.8 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III WD40 PF00400.32 EFC44360.1 - 2.8e-30 103.9 19.3 6.6e-06 26.8 0.5 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC44360.1 - 9.9e-07 29.0 0.0 2.3 8.6 0.0 4.3 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFC44360.1 - 2.1e-06 26.5 0.4 0.018 13.6 0.0 3.5 2 2 2 4 4 4 2 Cytochrome D1 heme domain WD40_like PF17005.5 EFC44360.1 - 0.046 13.0 1.3 3.2 7.0 0.0 3.3 4 0 0 4 4 4 0 WD40-like domain PD40 PF07676.12 EFC44360.1 - 0.085 12.8 0.0 32 4.6 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PQQ_3 PF13570.6 EFC44360.1 - 0.092 13.3 0.1 5.6 7.6 0.0 3.0 2 0 0 2 2 2 0 PQQ-like domain Pkinase PF00069.25 EFC44361.1 - 2.3e-11 43.6 0.0 2.7e-11 43.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44361.1 - 0.00032 20.1 0.0 0.00036 19.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ribosomal_S7e PF01251.18 EFC44362.1 - 5.4e-70 234.9 9.0 6.1e-70 234.7 9.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e CREPT PF16566.5 EFC44362.1 - 0.071 13.3 0.5 0.071 13.3 0.5 2.1 2 1 1 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour WD40 PF00400.32 EFC44363.1 - 7.9e-21 74.0 10.8 0.00013 22.7 0.0 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC44363.1 - 6.4e-06 26.4 1.3 0.45 10.9 0.0 5.4 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 EFC44363.1 - 0.0019 18.2 0.1 3.1 7.9 0.0 4.2 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PTEN_C2 PF10409.9 EFC44365.1 - 1.3e-17 63.8 0.6 2.5e-17 62.9 0.6 1.4 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EFC44365.1 - 2.5e-06 27.3 0.0 6e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC44365.1 - 2.8e-06 27.6 0.0 7.6e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFC44365.1 - 1.6e-05 24.6 0.0 3.1e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFC44365.1 - 3.3e-05 24.0 0.0 7.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family CDKN3 PF05706.12 EFC44365.1 - 0.0049 16.6 0.1 0.014 15.0 0.0 1.8 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 EFC44365.1 - 0.028 14.0 0.0 0.071 12.7 0.0 1.7 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-MIZ PF02891.20 EFC44366.1 - 6.1e-13 48.3 0.2 1.1e-12 47.4 0.2 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 EFC44366.1 - 3.4e-05 23.5 0.8 0.00045 19.9 0.1 2.8 3 0 0 3 3 3 1 SAP domain zf-Nse PF11789.8 EFC44366.1 - 0.0094 15.8 0.3 0.025 14.4 0.3 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Serglycin PF04360.12 EFC44366.1 - 0.094 12.7 0.3 0.21 11.5 0.3 1.6 1 0 0 1 1 1 0 Serglycin zf_UBZ PF18439.1 EFC44366.1 - 0.1 12.2 0.1 0.21 11.2 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger Oxysterol_BP PF01237.18 EFC44367.1 - 2.1e-60 204.6 9.4 7.6e-56 189.5 1.1 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein CaMBD PF02888.16 EFC44367.1 - 0.1 12.8 0.1 0.19 11.9 0.1 1.4 1 0 0 1 1 1 0 Calmodulin binding domain SH3_9 PF14604.6 EFC44368.1 - 1.3e-15 57.0 0.0 3.6e-09 36.3 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 EFC44368.1 - 4.1e-13 48.8 0.1 4.7e-07 29.4 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 EFC44368.1 - 1.8e-11 43.5 0.4 0.00018 21.1 0.1 3.3 3 1 0 3 3 3 2 SH3 domain PX PF00787.24 EFC44368.1 - 9.9e-08 32.0 1.5 2.6e-07 30.6 1.1 1.6 1 1 0 1 1 1 1 PX domain Ribosomal_L36e PF01158.18 EFC44368.1 - 0.011 15.9 0.1 0.021 15.1 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L36e His_Phos_2 PF00328.22 EFC44369.1 - 1.8e-16 60.5 0.7 6.6e-07 29.0 0.0 3.1 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 2) IMPa_N_2 PF18650.1 EFC44369.1 - 0.00057 19.2 0.2 0.38 10.0 0.0 2.3 2 0 0 2 2 2 2 Immunomodulating metalloprotease N-terminal domain DUF4461 PF14688.6 EFC44369.1 - 0.09 12.6 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4461) VPS9 PF02204.18 EFC44370.1 - 8.6e-17 61.3 0.1 2.3e-16 59.9 0.1 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain MORN PF02493.20 EFC44370.1 - 6.8e-16 57.1 18.7 0.00027 20.6 0.9 6.3 7 0 0 7 7 7 5 MORN repeat UQ_con PF00179.26 EFC44371.1 - 1.5e-16 60.3 0.3 1.6e-16 60.2 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC44371.1 - 0.008 16.5 0.1 0.0082 16.4 0.1 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 EFC44371.1 - 0.025 14.3 0.1 0.029 14.1 0.1 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B DYW_deaminase PF14432.6 EFC44372.1 - 1.7e-25 89.4 0.8 1.8e-25 89.2 0.8 1.0 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases dCMP_cyt_deam_1 PF00383.23 EFC44372.1 - 0.0077 16.1 0.1 0.0091 15.9 0.1 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region WD40 PF00400.32 EFC44373.1 - 1.4e-58 193.4 16.3 2.8e-10 40.6 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC44373.1 - 3.4e-18 65.7 0.2 0.0028 17.9 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC44373.1 - 1.6e-10 41.2 0.6 1.3e-07 31.7 0.3 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 EFC44373.1 - 5.9e-08 32.4 0.8 0.0058 16.0 0.1 3.4 2 2 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 EFC44373.1 - 8.6e-08 31.5 0.0 0.014 14.3 0.0 4.7 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 EFC44373.1 - 1.5e-07 30.5 5.6 0.053 12.2 0.8 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 HPS3_N PF14761.6 EFC44373.1 - 0.00034 20.2 0.1 0.021 14.3 0.0 2.9 2 2 1 3 3 3 2 Hermansky-Pudlak syndrome 3 Nbas_N PF15492.6 EFC44373.1 - 0.014 14.7 0.2 1 8.6 0.1 2.7 1 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 EFC44373.1 - 0.034 12.7 0.1 0.68 8.4 0.0 2.1 1 1 0 1 1 1 0 Cytochrome D1 heme domain Frtz PF11768.8 EFC44373.1 - 0.04 12.2 0.2 0.24 9.7 0.1 2.0 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz HTH_19 PF12844.7 EFC44374.1 - 0.19 11.8 0.7 0.46 10.5 0.2 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain TFIIA PF03153.13 EFC44374.1 - 1.4 8.8 17.3 1.8 8.4 17.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 EFC44374.1 - 1.6 8.2 7.6 2.1 7.8 7.6 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF4355 PF14265.6 EFC44375.1 - 0.0019 18.4 2.6 0.0026 18.0 2.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4355) Spc7 PF08317.11 EFC44375.1 - 0.0069 15.3 1.6 0.0074 15.2 1.6 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Pox_A_type_inc PF04508.12 EFC44375.1 - 0.012 15.4 3.5 0.067 13.1 0.1 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF3860 PF12976.7 EFC44375.1 - 0.022 14.7 0.2 0.034 14.2 0.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) HAUS6_N PF14661.6 EFC44375.1 - 0.031 13.9 1.2 0.033 13.7 1.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF3781 PF12636.7 EFC44375.1 - 0.039 13.8 2.6 0.098 12.5 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3781) PHM7_cyt PF14703.6 EFC44375.1 - 0.046 14.0 1.1 0.063 13.5 1.0 1.3 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter TSC22 PF01166.18 EFC44375.1 - 0.13 12.6 0.5 0.13 12.6 0.5 1.9 2 1 1 3 3 3 0 TSC-22/dip/bun family BshC PF10079.9 EFC44375.1 - 0.39 9.4 4.7 0.16 10.7 2.6 1.4 2 0 0 2 2 2 0 Bacillithiol biosynthesis BshC ABC_tran PF00005.27 EFC44376.1 - 2e-28 99.6 0.0 4.3e-28 98.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFC44376.1 - 1.6e-12 47.9 1.4 1.4e-09 38.2 0.1 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFC44376.1 - 1e-10 41.3 41.2 1.5e-10 40.7 41.2 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_15 PF13175.6 EFC44376.1 - 0.0002 21.2 0.0 0.41 10.3 0.0 2.3 1 1 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.19 EFC44376.1 - 0.0035 16.8 0.7 0.21 11.0 0.0 2.2 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain MeaB PF03308.16 EFC44376.1 - 0.14 11.1 0.3 0.24 10.3 0.3 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Snf7 PF03357.21 EFC44377.1 - 2.4e-14 53.3 14.2 2.4e-14 53.3 14.2 1.9 1 1 1 2 2 2 1 Snf7 CbiG_C PF01890.16 EFC44377.1 - 0.24 12.0 3.9 0.84 10.2 0.6 2.3 2 0 0 2 2 2 0 Cobalamin synthesis G C-terminus Ist1 PF03398.14 EFC44377.1 - 0.41 10.6 9.0 0.047 13.6 4.6 1.8 2 1 0 2 2 2 0 Regulator of Vps4 activity in the MVB pathway Kelch_3 PF13415.6 EFC44378.1 - 4.2e-13 49.2 1.5 0.019 15.3 0.1 4.7 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC44378.1 - 4.7e-12 45.7 4.0 0.0025 17.8 0.1 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC44378.1 - 6.1e-12 44.9 2.7 0.0041 16.7 0.0 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EFC44378.1 - 8.8e-12 44.7 6.7 0.0029 17.5 0.1 4.8 4 1 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 EFC44378.1 - 9.9e-11 41.5 8.2 0.00044 20.4 0.1 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 EFC44378.1 - 1.7e-09 37.3 5.5 0.041 13.9 0.0 4.5 4 1 0 4 4 4 4 Kelch motif DUF5074 PF16819.5 EFC44378.1 - 0.00098 19.2 0.3 0.019 15.0 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF5074) Dynamin_N PF00350.23 EFC44379.1 - 3.2e-11 43.6 3.2 3.9e-10 40.0 1.1 2.8 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFC44379.1 - 1.1e-05 25.5 0.3 0.003 17.6 0.3 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC44379.1 - 0.039 13.9 0.7 0.81 9.6 0.1 3.0 3 1 0 3 3 3 0 RsgA GTPase GT-D PF08759.11 EFC44379.1 - 0.94 9.1 9.3 0.75 9.4 1.8 2.8 3 0 0 3 3 3 0 Glycosyltransferase GT-D fold tRNA_int_end_N2 PF12928.7 EFC44380.1 - 0.00025 21.2 0.0 0.00048 20.2 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 EFC44380.1 - 0.029 14.0 0.0 0.074 12.7 0.0 1.6 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain PduV-EutP PF10662.9 EFC44381.1 - 0.028 14.2 1.1 0.27 11.0 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF4116 PF13475.6 EFC44382.1 - 4.1e-31 106.5 12.5 1.9e-12 46.7 0.4 4.5 2 1 3 5 5 5 5 Domain of unknown function (DUF4116) RP-C_C PF11800.8 EFC44382.1 - 0.052 13.6 0.0 0.073 13.2 0.0 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Ank_5 PF13857.6 EFC44383.1 - 1.2e-06 28.6 0.0 8.9e-06 25.9 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC44383.1 - 0.0088 16.6 0.0 0.68 10.6 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC44383.1 - 0.015 15.8 0.1 8.7 7.1 0.0 4.0 2 1 1 4 4 4 0 Ankyrin repeats (many copies) Ank PF00023.30 EFC44383.1 - 0.023 15.1 0.0 4.8 7.8 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.6 EFC44383.1 - 0.026 15.0 0.3 2.6 8.9 0.0 3.9 3 0 0 3 3 3 0 Ankyrin repeat F-box PF00646.33 EFC44383.1 - 0.051 13.5 0.2 0.38 10.7 0.0 2.6 2 1 0 2 2 2 0 F-box domain WD40 PF00400.32 EFC44384.1 - 3.5e-25 87.8 15.9 0.00018 22.3 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 EFC44384.1 - 0.033 12.8 1.9 0.4 9.3 0.1 3.1 1 1 2 5 5 5 0 Nucleoporin Nup120/160 EF-hand_7 PF13499.6 EFC44385.1 - 2.4e-22 79.2 6.1 8e-17 61.5 1.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC44385.1 - 9.5e-20 68.6 5.1 5.7e-07 28.6 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC44385.1 - 7.2e-16 56.7 2.2 0.00057 19.6 0.0 4.2 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFC44385.1 - 8.7e-13 47.1 2.5 8.9e-06 25.0 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFC44385.1 - 1.7e-12 47.0 6.6 0.00053 19.8 0.5 4.3 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 EFC44385.1 - 0.00011 22.2 0.9 0.092 12.7 0.0 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC44385.1 - 0.00081 19.7 3.0 0.3 11.4 0.1 3.5 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region AAA PF00004.29 EFC44386.1 - 1.7e-41 141.7 0.0 3.6e-41 140.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC44386.1 - 1.8e-10 40.5 0.1 3.7e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFC44386.1 - 3.2e-09 36.6 0.0 6.8e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EFC44386.1 - 3.1e-06 27.3 0.6 1.6e-05 24.9 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFC44386.1 - 7.6e-06 26.1 0.2 9.4e-05 22.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 EFC44386.1 - 1.8e-05 25.0 0.3 0.011 16.0 0.3 2.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFC44386.1 - 4.5e-05 22.7 0.0 8.5e-05 21.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EFC44386.1 - 5.5e-05 23.6 0.2 0.0007 20.0 0.1 2.5 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFC44386.1 - 0.0025 17.6 0.0 0.0054 16.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 EFC44386.1 - 0.0042 16.5 0.1 0.25 10.7 0.0 2.8 3 0 0 3 3 3 1 KaiC IstB_IS21 PF01695.17 EFC44386.1 - 0.011 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EFC44386.1 - 0.011 16.1 0.0 0.048 14.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 EFC44386.1 - 0.015 15.3 0.1 0.2 11.6 0.0 2.4 1 1 1 2 2 2 0 NACHT domain TIP49 PF06068.13 EFC44386.1 - 0.017 14.4 0.1 0.051 12.8 0.0 1.8 1 1 1 2 2 2 0 TIP49 P-loop domain NB-ARC PF00931.22 EFC44386.1 - 0.019 14.1 0.1 0.68 9.1 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain AAA_14 PF13173.6 EFC44386.1 - 0.028 14.4 0.0 0.7 9.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC44386.1 - 0.029 14.9 0.1 0.12 13.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFC44386.1 - 0.033 13.8 0.4 0.17 11.5 0.1 2.1 1 1 1 2 2 2 0 AAA domain AAA_3 PF07726.11 EFC44386.1 - 0.034 14.0 0.0 0.093 12.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC44386.1 - 0.036 13.8 0.1 0.14 11.8 0.0 2.0 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 EFC44386.1 - 0.045 13.5 1.2 0.18 11.5 0.1 2.5 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EFC44386.1 - 0.065 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC44386.1 - 0.065 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFC44386.1 - 0.069 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 EFC44386.1 - 0.09 12.2 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 EFC44386.1 - 0.17 11.6 0.2 0.4 10.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain SRAP PF02586.14 EFC44387.1 - 8e-42 143.2 0.0 7.8e-41 140.0 0.0 1.9 1 1 0 1 1 1 1 SOS response associated peptidase (SRAP) PTS_2-RNA PF01885.16 EFC44388.1 - 1.1e-59 201.5 0.2 1.3e-59 201.3 0.2 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Dehydrin PF00257.19 EFC44388.1 - 4.3 7.9 10.0 0.51 10.9 5.1 1.9 2 1 0 2 2 2 0 Dehydrin Metallophos PF00149.28 EFC44389.1 - 1.6e-16 61.4 0.5 2.6e-16 60.7 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PQQ PF01011.21 EFC44389.1 - 0.12 12.4 0.1 0.29 11.1 0.1 1.7 1 0 0 1 1 1 0 PQQ enzyme repeat Glyco_hydro_67C PF07477.12 EFC44389.1 - 0.4 10.2 2.8 4.1 6.9 0.2 2.6 2 1 1 3 3 3 0 Glycosyl hydrolase family 67 C-terminus TAP_C PF03943.13 EFC44390.1 - 1.2e-12 47.3 0.0 2.5e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 TAP C-terminal domain UBA_4 PF14555.6 EFC44390.1 - 4.5e-08 32.8 0.1 1.1e-07 31.5 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain LRR_4 PF12799.7 EFC44390.1 - 0.0002 21.7 5.1 0.004 17.5 3.1 3.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC44390.1 - 0.0037 17.0 2.5 0.02 14.7 2.5 2.3 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.6 EFC44390.1 - 0.065 12.7 0.1 0.15 11.5 0.1 1.6 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 EFC44390.1 - 0.29 11.3 3.5 86 3.6 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeat DUF4392 PF14336.6 EFC44391.1 - 1.2e-90 303.9 0.0 1.4e-90 303.8 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) ODC_AZ PF02100.17 EFC44392.1 - 1.1e-08 35.0 0.0 3.5e-08 33.4 0.0 1.8 1 1 1 2 2 2 1 Ornithine decarboxylase antizyme IGFL PF14653.6 EFC44392.1 - 0.066 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Insulin growth factor-like family UQ_con PF00179.26 EFC44394.1 - 2.8e-23 82.1 0.2 3.1e-23 82.0 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC44394.1 - 9.1e-06 26.0 0.8 1.2e-05 25.6 0.8 1.2 1 0 0 1 1 1 1 RWD domain zf-U1 PF06220.12 EFC44395.1 - 8.1e-07 28.7 2.6 8.1e-07 28.7 2.6 2.1 2 0 0 2 2 2 1 U1 zinc finger F-box PF00646.33 EFC44397.1 - 0.052 13.4 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC44397.1 - 0.089 12.7 0.0 0.34 10.8 0.0 1.9 2 0 0 2 2 2 0 F-box-like RhoGEF PF00621.20 EFC44398.1 - 2.3e-45 155.1 2.2 2.3e-45 155.1 2.2 2.9 3 1 0 3 3 3 1 RhoGEF domain SH3_9 PF14604.6 EFC44398.1 - 3.8e-08 33.0 0.0 7.2e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 EFC44398.1 - 1.4e-07 31.0 0.0 2.9e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 SH3 domain LsmAD PF06741.13 EFC44398.1 - 9 6.9 7.0 1.4 9.5 1.4 2.7 2 0 0 2 2 2 0 LsmAD domain Peptidase_M41 PF01434.18 EFC44399.1 - 3.4e-57 193.4 0.5 5.2e-57 192.8 0.5 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFC44399.1 - 7.3e-44 149.4 0.0 1.8e-43 148.1 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC44399.1 - 1.6e-11 43.8 0.5 6.2e-11 41.9 0.1 2.1 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 EFC44399.1 - 0.00013 22.4 0.6 0.041 14.3 0.3 2.5 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 EFC44399.1 - 0.00016 21.5 0.0 0.0004 20.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC44399.1 - 0.00016 22.0 0.1 0.4 11.0 0.1 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFC44399.1 - 0.00023 21.2 0.1 0.0013 18.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFC44399.1 - 0.00032 20.0 0.0 0.00065 19.0 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 EFC44399.1 - 0.017 15.3 0.0 0.071 13.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 EFC44399.1 - 0.017 14.9 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 EFC44399.1 - 0.038 14.5 0.2 0.15 12.6 0.2 2.2 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 EFC44399.1 - 0.045 13.7 0.2 0.14 12.1 0.2 1.8 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 EFC44399.1 - 0.045 13.8 0.1 0.096 12.7 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EFC44399.1 - 0.048 12.8 0.0 0.13 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 EFC44399.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC44399.1 - 0.081 12.4 0.1 0.5 9.8 0.1 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFC44399.1 - 0.084 12.6 0.0 0.28 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 EFC44399.1 - 0.095 13.1 0.1 0.43 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFC44399.1 - 0.11 11.9 0.2 0.22 10.9 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 EFC44399.1 - 0.13 11.5 1.1 0.45 9.8 1.0 1.9 1 1 1 2 2 2 0 Zeta toxin ABC_tran PF00005.27 EFC44399.1 - 0.14 12.6 1.0 0.51 10.8 1.0 1.9 1 0 0 1 1 1 0 ABC transporter Sigma54_activat PF00158.26 EFC44399.1 - 0.16 11.7 0.3 0.64 9.7 0.1 2.2 2 1 0 2 2 2 0 Sigma-54 interaction domain Myb_DNA-binding PF00249.31 EFC44400.1 - 2.3e-33 114.1 6.9 3.9e-16 59.0 1.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC44400.1 - 9.3e-28 96.3 7.0 1.4e-17 63.7 0.3 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 EFC44400.1 - 0.00077 19.5 6.6 0.12 12.4 0.1 3.4 3 1 1 4 4 4 2 SLIDE Rap1_C PF11626.8 EFC44400.1 - 0.045 13.9 0.0 8.5 6.5 0.0 2.6 1 1 1 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain SANT_DAMP1_like PF16282.5 EFC44400.1 - 0.055 13.7 0.3 5.2 7.3 0.1 2.5 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 EFC44400.1 - 0.12 12.3 3.4 0.29 11.1 0.5 2.9 3 1 0 3 3 3 0 Myb DNA-binding like Ribosomal_S11 PF00411.19 EFC44401.1 - 1.3e-47 160.7 0.6 1.6e-47 160.4 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 EFC44401.1 - 0.016 15.5 0.0 0.05 13.9 0.0 1.8 2 0 0 2 2 2 0 Carbohydrate binding domain (family 25) Iso_dh PF00180.20 EFC44403.1 - 6e-91 305.2 0.3 9.3e-91 304.5 0.3 1.2 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Imm27 PF15590.6 EFC44404.1 - 3.7 7.4 7.6 3.7 7.4 0.8 3.4 2 2 0 2 2 2 0 Immunity protein 27 COX5B PF01215.19 EFC44405.1 - 8.9e-06 25.4 0.0 1.6e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb ATP-synt_G PF04718.15 EFC44406.1 - 0.00012 22.9 0.2 0.00016 22.4 0.2 1.5 1 1 0 1 1 1 1 Mitochondrial ATP synthase g subunit SpoU_methylase PF00588.19 EFC44407.1 - 2e-16 60.4 0.0 4.7e-16 59.2 0.0 1.6 1 1 0 1 1 1 1 SpoU rRNA Methylase family YHS PF04945.13 EFC44407.1 - 0.019 15.0 0.6 0.038 14.1 0.1 1.8 2 0 0 2 2 2 0 YHS domain Laminin_G_3 PF13385.6 EFC44408.1 - 1.7e-17 64.0 2.5 2.9e-17 63.2 2.5 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 EFC44408.1 - 5.2e-05 23.0 0.1 9.8e-05 22.1 0.1 1.5 1 0 0 1 1 1 1 Pentaxin family TTRAP PF14203.6 EFC44408.1 - 0.012 15.6 0.0 0.044 13.7 0.0 2.0 2 0 0 2 2 2 0 Putative tranposon-transfer assisting protein DUF2340 PF10209.9 EFC44409.1 - 2e-42 144.4 2.6 2.2e-42 144.3 2.6 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) NMT PF01233.19 EFC44410.1 - 5.9e-70 234.2 0.2 1.2e-68 229.9 0.0 2.1 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 EFC44410.1 - 2.1e-65 220.2 0.1 3.1e-65 219.6 0.1 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain ATG11 PF10377.9 EFC44410.1 - 0.085 12.9 0.1 0.22 11.6 0.1 1.8 1 0 0 1 1 1 0 Autophagy-related protein 11 HU-CCDC81_euk_2 PF18289.1 EFC44411.1 - 1.4e-15 57.2 5.7 3e-15 56.1 0.4 3.0 3 0 0 3 3 3 1 CCDC81 eukaryotic HU domain 2 HU-CCDC81_euk_1 PF14908.6 EFC44411.1 - 1.8e-09 37.6 0.4 7.9e-09 35.6 0.4 2.2 1 0 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 Bac_DNA_binding PF00216.21 EFC44411.1 - 0.18 12.0 2.9 1.2 9.3 0.1 3.4 3 1 1 4 4 4 0 Bacterial DNA-binding protein TFIIA PF03153.13 EFC44411.1 - 1.6 8.6 29.1 0.11 12.5 20.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF1154 PF06631.11 EFC44411.1 - 6.8 6.8 12.1 1.4 9.0 0.2 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1154) Renin_r PF07850.14 EFC44412.1 - 0.11 13.1 0.1 0.11 13.1 0.1 5.2 5 1 0 5 5 5 0 Renin receptor-like protein 4HB_MCP_1 PF12729.7 EFC44412.1 - 0.89 9.1 8.0 2.1 7.8 0.7 4.0 4 0 0 4 4 4 0 Four helix bundle sensory module for signal transduction DUF5446 PF17522.2 EFC44412.1 - 9.8 6.4 11.7 1.2 9.4 0.9 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5446) Guanylate_cyc PF00211.20 EFC44413.1 - 6.4e-51 172.6 0.0 2.5e-50 170.7 0.0 2.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC44413.1 - 3.6e-16 59.3 0.1 1.5e-15 57.3 0.1 2.2 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC44413.1 - 1.2e-10 41.3 0.0 3.1e-10 40.0 0.0 1.8 1 0 0 1 1 1 1 PAS fold DUF5113 PF17140.4 EFC44413.1 - 0.012 15.4 2.5 0.22 11.3 0.1 3.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) DUF3899 PF13038.6 EFC44413.1 - 0.022 15.2 2.6 0.19 12.2 1.6 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Amnionless PF14828.6 EFC44413.1 - 0.03 13.1 2.7 1.1 8.0 0.1 3.6 4 0 0 4 4 4 0 Amnionless PAS_10 PF13596.6 EFC44413.1 - 0.073 13.7 0.0 0.21 12.2 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 EFC44413.1 - 0.086 13.1 0.0 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 PAS fold Mid2 PF04478.12 EFC44413.1 - 0.56 10.0 5.3 12 5.7 0.0 3.3 3 0 0 3 3 3 0 Mid2 like cell wall stress sensor Acetyltransf_9 PF13527.7 EFC44414.1 - 0.00089 19.3 0.0 0.0027 17.8 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Pyridoxal_deC PF00282.19 EFC44415.1 - 8.7e-23 80.6 0.0 2.3e-14 52.9 0.0 3.2 3 0 0 3 3 3 3 Pyridoxal-dependent decarboxylase conserved domain Fzo_mitofusin PF04799.13 EFC44415.1 - 0.068 12.7 0.3 0.13 11.8 0.3 1.4 1 0 0 1 1 1 0 fzo-like conserved region Homoserine_dh PF00742.19 EFC44415.1 - 0.21 11.5 0.0 0.42 10.5 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase GTA_TIM PF13547.6 EFC44416.1 - 4.9e-05 22.8 0.1 0.00014 21.3 0.0 1.7 1 1 1 2 2 2 1 GTA TIM-barrel-like domain ABC2_membrane_3 PF12698.7 EFC44417.1 - 0.0006 19.0 14.5 0.0006 19.0 14.5 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein 7tm_3 PF00003.22 EFC44417.1 - 0.18 11.5 16.6 0.26 11.0 16.6 1.2 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR HisKA_7TM PF16927.5 EFC44417.1 - 0.59 10.1 14.0 0.83 9.6 14.0 1.3 1 0 0 1 1 1 0 N-terminal 7TM region of histidine kinase Gaa1 PF04114.14 EFC44417.1 - 0.59 9.1 6.8 0.9 8.5 6.8 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component EI24 PF07264.11 EFC44417.1 - 0.87 9.8 11.7 1.3 9.2 11.7 1.3 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF2975 PF11188.8 EFC44417.1 - 3.1 7.7 12.1 11 5.9 9.6 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2975) Glyco_transf_18 PF15024.6 EFC44418.1 - 2.8e-08 32.8 7.9 4.7e-08 32.1 7.9 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 18 Sel1 PF08238.12 EFC44419.1 - 2.8e-62 205.7 26.9 6.1e-11 42.6 0.0 8.8 8 0 0 8 8 8 8 Sel1 repeat Scramblase PF03803.15 EFC44419.1 - 1.2e-48 165.3 0.2 1.7e-48 164.8 0.2 1.2 1 0 0 1 1 1 1 Scramblase TPR_16 PF13432.6 EFC44419.1 - 3.4e-06 27.6 8.9 2.3 8.9 0.1 5.4 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44419.1 - 5.2e-06 26.1 6.1 0.083 13.0 0.1 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44419.1 - 6.2e-05 23.4 7.9 7.3 7.5 0.4 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44419.1 - 0.0005 20.3 10.6 1.5 9.2 1.0 5.3 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC44419.1 - 0.015 15.1 11.6 7.7 6.5 0.0 6.1 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_20 PF14561.6 EFC44419.1 - 0.016 15.5 3.0 2.5 8.5 0.1 4.2 2 1 3 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44419.1 - 0.019 15.1 1.9 0.019 15.1 1.9 8.8 9 2 1 10 10 10 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44419.1 - 0.053 13.8 0.8 0.053 13.8 0.8 7.7 7 2 0 8 8 8 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC44419.1 - 0.08 13.0 1.5 3.3 7.8 0.5 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC44419.1 - 0.17 12.3 7.7 17 6.0 0.2 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44419.1 - 2.2 8.2 33.6 0.1 12.5 1.0 8.8 10 2 1 11 11 11 0 Tetratricopeptide repeat G-alpha PF00503.20 EFC44420.1 - 4.9e-91 305.5 4.4 6.1e-91 305.2 4.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC44420.1 - 3e-11 43.1 1.5 2e-08 33.9 0.1 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC44420.1 - 0.00026 20.6 0.1 0.0035 16.9 0.1 2.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC44420.1 - 0.00061 19.2 0.4 0.12 11.7 0.1 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC44420.1 - 0.0036 17.4 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase Roc PF08477.13 EFC44420.1 - 0.026 14.7 0.3 8.1 6.7 0.0 2.8 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 EFC44420.1 - 0.083 12.6 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SNF PF00209.18 EFC44422.1 - 3.7e-57 194.2 50.9 3.1e-35 121.9 22.3 3.0 1 1 2 3 3 3 3 Sodium:neurotransmitter symporter family DUF1295 PF06966.12 EFC44423.1 - 3.7e-52 177.2 10.7 4.8e-52 176.8 10.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 EFC44423.1 - 5e-10 39.6 1.1 5e-10 39.6 1.1 1.8 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 EFC44423.1 - 0.00086 19.7 2.5 0.0015 18.9 0.0 2.5 3 0 0 3 3 3 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFC44423.1 - 0.012 16.0 0.1 0.012 16.0 0.1 2.7 2 2 0 2 2 2 0 Phospholipid methyltransferase Chordopox_A20R PF05941.13 EFC44423.1 - 0.16 10.9 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Chordopoxvirus A20R protein DUF4382 PF14321.6 EFC44424.1 - 0.0084 16.4 0.8 0.013 15.7 0.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4382) ABC1 PF03109.16 EFC44425.1 - 1.5e-27 96.1 0.1 5.1e-27 94.4 0.1 2.0 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 EFC44425.1 - 0.056 13.3 0.3 0.11 12.4 0.3 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4116 PF13475.6 EFC44426.1 - 9.7e-36 121.3 25.2 1.7e-11 43.7 0.0 9.0 6 3 2 8 8 8 6 Domain of unknown function (DUF4116) RecG_wedge PF17191.4 EFC44426.1 - 0.046 13.3 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 RecG wedge domain DrsE PF02635.15 EFC44426.1 - 0.12 12.7 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 DsrE/DsrF-like family PSI_PsaF PF02507.15 EFC44426.1 - 0.13 12.1 0.1 0.23 11.3 0.1 1.3 1 0 0 1 1 1 0 Photosystem I reaction centre subunit III BTB PF00651.31 EFC44427.1 - 9.9e-10 38.6 2.7 0.00021 21.5 0.3 2.9 2 0 0 2 2 2 2 BTB/POZ domain Kelch_5 PF13854.6 EFC44427.1 - 1.1e-08 34.9 7.7 0.0045 16.9 0.0 5.5 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 EFC44427.1 - 4.7e-08 32.9 8.5 0.12 12.4 0.0 6.4 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC44427.1 - 1.6e-06 27.6 0.7 0.24 11.0 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 EFC44427.1 - 0.0013 19.0 2.3 16 6.0 0.1 5.4 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 EFC44427.1 - 0.0092 16.3 7.7 27 5.2 0.1 5.9 6 0 0 6 6 6 1 Galactose oxidase, central domain Ras PF00071.22 EFC44428.1 - 2.1e-17 63.2 0.0 4.4e-17 62.2 0.0 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44428.1 - 1.5e-08 34.9 0.0 5.2e-08 33.1 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44428.1 - 1.1e-07 31.5 0.0 1.7e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 EFC44428.1 - 6.8e-07 29.0 0.3 1.9e-06 27.6 0.1 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC44428.1 - 7e-06 25.8 0.1 1.4e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 F-box-like Gtr1_RagA PF04670.12 EFC44428.1 - 1.1e-05 25.0 0.0 1.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region HSR PF03172.13 EFC44428.1 - 0.01 16.0 0.8 0.19 11.9 0.7 2.5 2 0 0 2 2 2 0 HSR domain F-box_4 PF15966.5 EFC44428.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.7 1 0 0 1 1 1 0 F-box MMR_HSR1 PF01926.23 EFC44428.1 - 0.014 15.4 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase BUD22 PF09073.10 EFC44430.1 - 0.092 12.1 11.5 0.12 11.6 11.5 1.1 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 EFC44430.1 - 1.5 6.9 23.7 2.3 6.2 23.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi LNS2 PF08235.13 EFC44431.1 - 1.2e-53 181.9 0.0 2.3e-53 181.0 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EFC44431.1 - 0.00018 21.5 0.1 0.00068 19.6 0.1 2.0 2 0 0 2 2 2 1 lipin, N-terminal conserved region Hydrolase_3 PF08282.12 EFC44431.1 - 0.33 10.7 0.0 0.33 10.7 0.0 3.0 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase Ndc1_Nup PF09531.10 EFC44431.1 - 3 6.4 5.6 4.9 5.7 5.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NHL PF01436.21 EFC44432.1 - 8.5e-79 255.9 14.2 6.3e-08 32.3 0.0 15.8 15 0 0 15 15 15 12 NHL repeat RGS PF00615.19 EFC44432.1 - 6.1e-13 49.1 5.3 1.8e-12 47.6 5.3 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain SGL PF08450.12 EFC44432.1 - 4e-11 43.0 15.4 0.0036 16.9 0.2 7.7 5 2 0 6 6 6 4 SMP-30/Gluconolactonase/LRE-like region GPS PF01825.21 EFC44432.1 - 1.8e-05 25.1 4.8 4.4e-05 23.9 4.8 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Phytase-like PF13449.6 EFC44432.1 - 9.3e-05 22.5 0.3 22 4.9 0.0 5.4 6 0 0 6 6 6 0 Esterase-like activity of phytase Bac_export_2 PF01312.19 EFC44432.1 - 0.038 13.2 12.9 0.089 12.0 12.9 1.6 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Linker_histone PF00538.19 EFC44432.1 - 0.071 13.5 5.2 1.9e+02 2.5 0.0 7.3 8 0 0 8 8 8 0 linker histone H1 and H5 family DPM2 PF07297.12 EFC44432.1 - 0.16 12.3 6.0 0.56 10.5 6.0 2.0 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Arylesterase PF01731.20 EFC44432.1 - 0.45 10.8 20.9 5.7 7.2 0.2 8.6 9 1 0 9 9 9 0 Arylesterase BLYB PF05289.11 EFC44432.1 - 0.63 10.3 15.2 0.094 12.9 0.4 4.0 4 0 0 4 4 4 0 Borrelia hemolysin accessory protein SPRY PF00622.28 EFC44435.1 - 7.1e-07 29.4 0.5 9.1e-07 29.0 0.5 1.1 1 0 0 1 1 1 1 SPRY domain ELFV_dehydrog PF00208.21 EFC44436.1 - 5.8e-12 45.8 3.2 5.8e-12 45.8 3.2 2.3 2 1 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EFC44436.1 - 1.6e-08 34.5 0.0 3.3e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Methyltransf_25 PF13649.6 EFC44436.1 - 0.0071 17.0 0.0 0.022 15.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain NAD_binding_7 PF13241.6 EFC44436.1 - 0.028 14.9 0.0 0.078 13.4 0.0 1.8 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFC44436.1 - 0.031 14.3 0.0 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase VPS9 PF02204.18 EFC44437.1 - 4.3e-14 52.6 0.1 2.2e-13 50.3 0.1 2.3 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PH PF00169.29 EFC44437.1 - 0.00039 20.9 1.8 0.015 15.8 0.1 4.0 3 0 0 3 3 3 1 PH domain CDT1_C PF16679.5 EFC44437.1 - 1.5 9.3 6.2 0.5 10.8 1.6 2.6 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Peptidase_M60 PF13402.6 EFC44438.1 - 6.4e-64 216.1 3.2 9.2e-64 215.6 3.2 1.2 1 0 0 1 1 1 1 Peptidase M60, enhancin and enhancin-like M60-like_N PF17291.2 EFC44438.1 - 6.8e-25 87.1 0.2 2.1e-24 85.5 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of M60-like peptidases ThuA PF06283.11 EFC44438.1 - 0.06 13.6 0.1 0.27 11.4 0.0 1.9 2 0 0 2 2 2 0 Trehalose utilisation Peptidase_M13 PF01431.21 EFC44438.1 - 0.084 12.5 0.3 0.15 11.7 0.3 1.4 1 0 0 1 1 1 0 Peptidase family M13 DUF5643 PF18705.1 EFC44438.1 - 0.086 12.8 0.2 0.18 11.8 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5643) Exo_endo_phos PF03372.23 EFC44439.1 - 1.6e-15 57.2 0.0 2.6e-15 56.6 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family HTH_50 PF18024.1 EFC44439.1 - 0.14 11.8 0.1 0.34 10.6 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1189 PF06691.11 EFC44439.1 - 2.2 7.8 4.8 0.42 10.2 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) UCH PF00443.29 EFC44440.1 - 4.6e-45 154.1 9.5 4.6e-45 154.1 9.5 3.1 4 0 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 EFC44440.1 - 7.6e-13 48.1 0.1 2.2e-12 46.6 0.1 1.9 1 0 0 1 1 1 1 UBA/TS-N domain UCH_1 PF13423.6 EFC44440.1 - 2.9e-05 23.8 12.0 2.9e-05 23.8 12.0 3.3 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UIM PF02809.20 EFC44440.1 - 0.0079 16.0 1.8 0.032 14.1 1.8 2.2 1 0 0 1 1 1 1 Ubiquitin interaction motif CUE PF02845.16 EFC44440.1 - 0.01 15.5 0.0 0.033 13.9 0.0 1.9 1 0 0 1 1 1 0 CUE domain UBA_3 PF09288.10 EFC44440.1 - 0.01 15.6 0.6 0.044 13.6 0.0 2.4 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain UBA_4 PF14555.6 EFC44440.1 - 0.021 14.7 0.1 0.061 13.1 0.1 1.9 1 0 0 1 1 1 0 UBA-like domain zf-Tim10_DDP PF02953.15 EFC44440.1 - 0.05 13.3 4.9 0.13 11.9 3.4 2.6 2 0 0 2 2 2 0 Tim10/DDP family zinc finger Phage_connect_1 PF05135.13 EFC44440.1 - 0.49 10.9 4.5 5.2 7.6 0.7 4.1 3 0 0 3 3 2 0 Phage gp6-like head-tail connector protein DUF2312 PF10073.9 EFC44440.1 - 0.58 9.8 5.7 0.29 10.8 0.2 3.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) HSBP1 PF06825.12 EFC44440.1 - 5.5 6.9 7.4 4.2 7.3 0.5 3.8 4 0 0 4 4 4 0 Heat shock factor binding protein 1 Peptidase_C2 PF00648.21 EFC44441.1 - 1e-73 248.0 0.0 3e-73 246.5 0.0 1.8 2 0 0 2 2 2 1 Calpain family cysteine protease Jnk-SapK_ap_N PF09744.9 EFC44441.1 - 0.06 13.6 9.2 0.4 10.9 9.3 2.2 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Nup54 PF13874.6 EFC44441.1 - 0.55 10.3 4.3 0.62 10.2 1.8 2.2 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF4404 PF14357.6 EFC44441.1 - 1 10.0 4.9 0.49 11.1 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Retrotrans_gag PF03732.17 EFC44441.1 - 1.1 9.5 5.2 4.3 7.7 0.5 3.5 3 1 1 4 4 4 0 Retrotransposon gag protein CpxA_peri PF16527.5 EFC44441.1 - 2.9 8.3 10.7 1 9.7 0.4 3.2 1 1 3 4 4 4 0 Two-component sensor protein CpxA, periplasmic domain COG5 PF10392.9 EFC44441.1 - 3.1 8.0 7.6 4.6 7.4 2.2 2.9 1 1 2 3 3 3 0 Golgi transport complex subunit 5 HMMR_N PF15905.5 EFC44441.1 - 6.3 6.2 19.5 0.65 9.4 13.7 2.0 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal SNAP PF14938.6 EFC44442.1 - 1.4e-75 254.4 21.5 1.7e-75 254.1 21.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP MIT PF04212.18 EFC44442.1 - 4.2e-05 23.5 12.5 0.033 14.3 2.5 5.4 2 1 3 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 EFC44442.1 - 8e-05 22.2 1.3 0.00011 21.7 1.3 1.2 1 0 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 EFC44442.1 - 8.6e-05 22.8 5.6 0.0009 19.5 2.6 3.4 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44442.1 - 0.00058 20.5 3.0 0.11 13.4 0.1 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44442.1 - 0.00058 19.6 0.0 0.00058 19.6 0.0 4.3 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44442.1 - 0.00063 19.7 11.5 0.0062 16.6 0.1 4.7 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44442.1 - 0.0028 17.6 4.6 0.068 13.2 0.0 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC5 PF12862.7 EFC44442.1 - 0.0032 17.5 5.2 0.0049 16.9 2.0 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 5 DHR-2 PF06920.13 EFC44442.1 - 0.0058 15.3 1.7 0.0058 15.3 1.7 1.6 1 1 1 2 2 2 1 Dock homology region 2 TPR_6 PF13174.6 EFC44442.1 - 0.014 16.0 2.3 12 6.8 0.0 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44442.1 - 0.017 15.3 7.1 0.071 13.4 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44442.1 - 0.032 13.9 4.0 2.6 7.8 0.0 4.1 4 0 0 4 4 4 0 TPR repeat TPR_19 PF14559.6 EFC44442.1 - 0.046 14.2 3.6 0.061 13.8 0.7 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Spatacsin_C PF14649.6 EFC44442.1 - 0.076 12.1 7.1 0.51 9.4 6.5 2.5 1 1 1 2 2 2 0 Spatacsin C-terminus DUF1722 PF08349.11 EFC44442.1 - 0.12 12.7 1.6 0.45 10.8 0.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) NSF PF02071.20 EFC44442.1 - 0.57 11.2 21.7 6 8.1 0.8 6.8 6 0 0 6 6 5 0 Aromatic-di-Alanine (AdAR) repeat TPR_16 PF13432.6 EFC44442.1 - 0.75 10.5 3.9 2 9.1 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF357 PF04010.13 EFC44442.1 - 1.4 9.0 4.6 1 9.5 1.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF357) Arm PF00514.23 EFC44443.1 - 2.9e-27 93.8 13.7 1.1e-06 28.5 0.2 5.6 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC44443.1 - 1e-11 45.1 0.2 0.0011 19.5 0.0 4.2 3 1 1 4 4 4 3 HEAT-like repeat HEAT_2 PF13646.6 EFC44443.1 - 1.1e-05 25.8 0.1 0.00039 20.8 0.0 2.8 2 1 0 2 2 2 1 HEAT repeats RICTOR_V PF14668.6 EFC44443.1 - 0.00026 21.2 2.1 1.6 9.0 0.0 4.2 3 1 2 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_PBS PF03130.16 EFC44443.1 - 0.0016 18.9 0.4 86 4.3 0.0 4.9 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat HEAT PF02985.22 EFC44443.1 - 0.0045 17.1 2.5 1.9 9.0 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat V-ATPase_H_C PF11698.8 EFC44443.1 - 0.055 13.6 0.0 0.3 11.2 0.0 1.9 2 0 0 2 2 2 0 V-ATPase subunit H PPPI_inhib PF14895.6 EFC44444.1 - 2e-12 47.0 5.8 2.6e-12 46.6 5.8 1.3 1 0 0 1 1 1 1 Protein phosphatase 1 inhibitor DUF4263 PF14082.6 EFC44444.1 - 0.021 15.1 0.3 1.1 9.5 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4263) GST_N_3 PF13417.6 EFC44445.1 - 5.3e-09 36.4 0.0 4.6e-08 33.4 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC44445.1 - 1.3e-08 34.9 0.3 3.8e-08 33.4 0.1 1.8 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC44445.1 - 1.4e-07 31.5 0.0 2.4e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC44445.1 - 1.6e-06 28.4 0.0 3.3e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC44445.1 - 2.7e-06 27.5 0.1 6.4e-06 26.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC44445.1 - 6.8e-06 26.3 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 EFC44445.1 - 0.0068 16.7 0.0 0.021 15.1 0.0 1.9 2 1 0 2 2 2 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 EFC44445.1 - 0.037 14.8 0.0 0.12 13.1 0.0 1.9 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain PCAF_N PF06466.11 EFC44446.1 - 0.049 13.2 0.6 0.13 11.9 0.1 1.9 2 0 0 2 2 2 0 PCAF (P300/CBP-associated factor) N-terminal domain NTF2 PF02136.20 EFC44447.1 - 2.7e-28 99.0 0.0 3e-28 98.8 0.0 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain GMP_PDE_delta PF05351.11 EFC44448.1 - 2.1e-30 105.9 0.0 3e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 GMP-PDE, delta subunit AMP-binding PF00501.28 EFC44449.1 - 2e-83 280.4 0.0 2.6e-83 280.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme GerD PF17898.1 EFC44449.1 - 0.12 12.3 0.2 0.28 11.2 0.2 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain F-box PF00646.33 EFC44450.1 - 3.7e-05 23.5 0.0 0.0002 21.2 0.0 2.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC44450.1 - 0.016 15.1 0.0 0.066 13.1 0.0 2.1 1 0 0 1 1 1 0 F-box-like LRR_8 PF13855.6 EFC44450.1 - 0.025 14.4 12.2 0.064 13.0 0.4 5.6 5 2 2 7 7 7 0 Leucine rich repeat PPR PF01535.20 EFC44451.1 - 2.4e-19 68.1 6.5 0.00044 20.3 0.0 7.6 8 0 0 8 8 8 5 PPR repeat PPR_2 PF13041.6 EFC44451.1 - 5.5e-14 52.1 15.9 7.5e-05 22.9 0.4 7.9 6 2 2 8 8 8 4 PPR repeat family PPR_1 PF12854.7 EFC44451.1 - 6.3e-08 32.2 0.4 0.00032 20.3 0.0 3.6 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 EFC44451.1 - 6.8e-08 32.5 17.3 0.072 13.2 0.0 7.2 4 2 4 8 8 8 4 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC44451.1 - 1e-06 28.3 2.0 0.0011 18.4 0.1 3.6 1 1 2 3 3 3 1 Pentacotripeptide-repeat region of PRORP TPR_8 PF13181.6 EFC44451.1 - 0.00049 20.1 11.2 0.017 15.3 0.1 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44451.1 - 0.00059 20.3 0.5 0.32 11.5 0.1 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44451.1 - 0.00067 19.6 10.5 0.18 12.0 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat ATP13 PF12921.7 EFC44451.1 - 0.0014 18.5 4.3 0.14 12.0 0.2 3.7 2 1 0 3 3 3 1 Mitochondrial ATPase expression TPR_7 PF13176.6 EFC44451.1 - 0.0014 18.5 4.3 1.1 9.5 0.0 5.8 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44451.1 - 0.0038 17.9 0.0 7.6 7.6 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44451.1 - 0.014 15.2 17.7 0.091 12.6 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44451.1 - 0.018 15.3 2.4 0.21 11.9 0.1 3.4 3 2 0 3 3 3 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC44451.1 - 0.047 13.4 3.8 0.24 11.1 0.1 3.2 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_16 PF13432.6 EFC44451.1 - 0.082 13.6 0.2 8.6 7.1 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TRPM_tetra PF16519.5 EFC44451.1 - 0.084 13.0 0.4 3.4 7.9 0.1 2.8 3 0 0 3 3 3 0 Tetramerisation domain of TRPM TPR_6 PF13174.6 EFC44451.1 - 0.75 10.6 3.1 15 6.5 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat DJ-1_PfpI PF01965.24 EFC44452.1 - 1.7e-38 132.0 0.6 2e-38 131.8 0.6 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 EFC44452.1 - 0.042 13.4 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain FLYWCH PF04500.16 EFC44453.1 - 0.0028 17.7 2.4 0.0051 16.9 2.4 1.4 1 0 0 1 1 1 1 FLYWCH zinc finger domain Ribosomal_S30 PF04758.14 EFC44454.1 - 7.7e-07 29.2 1.0 7.7e-07 29.2 1.0 2.1 1 1 1 2 2 2 1 Ribosomal protein S30 BsuPI PF12690.7 EFC44454.1 - 0.016 15.2 0.6 0.024 14.7 0.5 1.4 1 1 0 1 1 1 0 Intracellular proteinase inhibitor DUF4154 PF13689.6 EFC44455.1 - 0.072 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 YfiR/HmsC-like tRNA-synt_2b PF00587.25 EFC44456.1 - 2e-35 122.4 0.1 4.5e-35 121.2 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFC44456.1 - 9.7e-23 80.1 2.3 1.5e-22 79.5 0.9 2.0 2 0 0 2 2 2 1 Anticodon binding domain TGS PF02824.21 EFC44456.1 - 8.4e-11 41.8 0.0 1.7e-10 40.7 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 EFC44456.1 - 2.4e-08 33.9 0.0 4.7e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Copine PF07002.16 EFC44457.1 - 7.1e-73 244.7 0.0 1e-72 244.1 0.0 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFC44457.1 - 4e-25 88.1 0.1 1.7e-11 44.3 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFC44457.1 - 7.4e-06 26.2 0.0 2.1e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 vWA found in TerF C terminus VWA_3 PF13768.6 EFC44457.1 - 0.013 15.4 0.0 0.063 13.2 0.0 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain SNF2_N PF00176.23 EFC44458.1 - 3.7e-43 147.6 0.3 8.9e-43 146.3 0.3 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC44458.1 - 6e-18 65.2 0.6 4.3e-17 62.4 0.2 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC44458.1 - 1e-12 48.4 0.0 1e-12 48.4 0.0 3.6 3 2 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_34 PF13872.6 EFC44458.1 - 1.2e-05 24.3 0.1 4.9e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 SWI2_SNF2 PF18766.1 EFC44458.1 - 1.3e-05 25.0 1.7 4.9e-05 23.1 0.0 2.8 2 1 0 2 2 2 1 SWI2/SNF2 ATPase Med15_fungi PF05397.12 EFC44458.1 - 0.033 14.5 3.5 0.11 12.8 3.5 1.9 1 0 0 1 1 1 0 Mediator complex subunit 15 Chromo PF00385.24 EFC44459.1 - 8e-19 67.3 8.0 4.7e-11 42.4 2.2 2.8 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 EFC44459.1 - 0.096 12.6 0.9 5.8 6.9 0.1 2.7 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain NHL PF01436.21 EFC44461.1 - 4.8e-33 111.5 3.0 1.9e-06 27.6 0.0 7.2 6 1 0 6 6 6 6 NHL repeat BTB PF00651.31 EFC44461.1 - 7.7e-14 51.9 1.7 1.9e-13 50.6 1.7 1.7 1 0 0 1 1 1 1 BTB/POZ domain SGL PF08450.12 EFC44461.1 - 5.2e-05 22.9 0.1 0.52 9.9 0.0 3.0 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EFC44461.1 - 0.00047 20.2 0.1 4.4 7.5 0.0 4.2 3 1 0 3 3 3 2 Strictosidine synthase Arylesterase PF01731.20 EFC44461.1 - 0.0043 17.2 1.2 0.45 10.7 0.0 4.4 6 0 0 6 6 6 1 Arylesterase Phytase-like PF13449.6 EFC44461.1 - 0.1 12.6 0.3 87 2.9 0.0 4.2 3 1 1 4 4 4 0 Esterase-like activity of phytase DUF3342 PF11822.8 EFC44461.1 - 0.11 12.7 0.3 0.11 12.7 0.3 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) zf-SAP30 PF13866.6 EFC44461.1 - 0.14 12.3 0.8 8.1 6.6 0.0 3.1 4 0 0 4 4 4 0 SAP30 zinc-finger Flavoprotein PF02441.19 EFC44462.1 - 1.9e-46 157.7 0.1 2.3e-46 157.5 0.1 1.0 1 0 0 1 1 1 1 Flavoprotein ABC2_membrane PF01061.24 EFC44464.1 - 5e-43 147.0 18.9 8.6e-43 146.2 18.9 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC44464.1 - 3.2e-20 73.0 0.9 4.7e-20 72.5 0.3 1.6 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 EFC44464.1 - 0.002 17.6 0.5 1.6 8.1 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC44464.1 - 0.0064 16.4 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC44464.1 - 0.0067 16.1 1.3 0.016 14.9 1.3 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFC44464.1 - 0.042 13.6 0.2 0.21 11.3 0.1 2.2 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 EFC44464.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.6 EFC44464.1 - 1 9.8 5.3 2.8 8.4 4.8 2.1 1 1 0 1 1 1 0 AAA domain BRCT PF00533.26 EFC44465.1 - 1.6e-13 50.8 1.2 5e-13 49.2 1.2 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC44465.1 - 6e-12 45.8 0.3 1.3e-11 44.7 0.3 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFC44465.1 - 3.4e-06 26.9 0.5 7.6e-06 25.8 0.5 1.6 1 0 0 1 1 1 1 twin BRCT domain F-box PF00646.33 EFC44465.1 - 2.3e-05 24.2 0.1 6.3e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC44465.1 - 5.4e-05 23.0 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 F-box-like LIG3_BRCT PF16759.5 EFC44465.1 - 0.00056 20.2 0.4 0.0041 17.4 0.1 2.5 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain CENP-B_dimeris PF09026.10 EFC44465.1 - 2.3 8.6 17.3 0.14 12.6 5.7 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 EFC44465.1 - 6.4 6.8 8.7 1.4 8.9 4.0 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal TIG PF01833.24 EFC44466.1 - 9.8e-09 35.2 12.6 1.9e-08 34.3 12.4 1.6 1 1 0 1 1 1 1 IPT/TIG domain DUF5008 PF16400.5 EFC44466.1 - 5.3e-05 23.3 0.7 7.5e-05 22.8 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5008) DUF5412 PF17428.2 EFC44466.1 - 0.022 14.6 0.4 0.032 14.1 0.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5412) Methyltransf_5 PF01795.19 EFC44467.1 - 8.6e-70 235.7 1.9 3.6e-69 233.6 1.9 1.9 1 1 0 1 1 1 1 MraW methylase family HHH_3 PF12836.7 EFC44467.1 - 0.026 14.8 0.0 0.06 13.6 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif Orbi_NS3 PF01616.16 EFC44467.1 - 0.041 13.6 0.1 0.072 12.8 0.1 1.3 1 0 0 1 1 1 0 Orbivirus NS3 MUG113 PF13455.6 EFC44467.1 - 0.088 13.5 0.1 0.23 12.2 0.1 1.7 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 COMM_domain PF07258.14 EFC44468.1 - 4.9e-22 77.8 0.5 6e-22 77.5 0.5 1.1 1 0 0 1 1 1 1 COMM domain TRAPP PF04051.16 EFC44469.1 - 1.3e-27 96.3 0.0 1.5e-27 96.1 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Glycos_transf_2 PF00535.26 EFC44470.1 - 2.3e-18 66.6 0.1 3.3e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 EFC44470.1 - 0.00033 20.2 0.1 0.00043 19.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_3 PF13641.6 EFC44470.1 - 0.006 16.5 0.0 0.0077 16.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EFC44470.1 - 0.048 14.2 0.1 0.15 12.6 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 2 Adaptin_binding PF10199.9 EFC44470.1 - 0.14 12.7 0.1 0.21 12.2 0.1 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 UQ_con PF00179.26 EFC44471.1 - 2.2e-55 186.1 0.2 2.5e-55 186.0 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC44471.1 - 0.00013 21.6 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFC44471.1 - 0.0068 16.7 0.2 0.0076 16.5 0.2 1.4 1 1 0 1 1 1 1 RWD domain DUF2207 PF09972.9 EFC44472.1 - 0.0017 17.2 0.9 0.002 17.0 0.9 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) UPF0565 PF10561.9 EFC44472.1 - 0.013 14.7 0.2 0.016 14.4 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 Sec62 PF03839.16 EFC44472.1 - 0.029 13.9 0.1 0.031 13.8 0.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RAMP4 PF06624.12 EFC44472.1 - 0.11 12.5 0.5 0.11 12.5 0.5 1.7 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 RCC1_2 PF13540.6 EFC44474.1 - 6.2e-17 60.9 24.1 0.011 15.5 0.1 9.6 10 0 0 10 10 10 7 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC44474.1 - 8.3e-16 58.4 16.6 0.0012 19.4 0.0 9.8 10 1 0 10 10 10 3 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC44474.1 - 0.002 18.5 6.6 0.0047 17.3 6.6 1.6 1 0 0 1 1 1 1 EGF-like domain Fic PF02661.18 EFC44475.1 - 2.5e-18 66.8 0.1 8.6e-18 65.0 0.1 1.9 1 0 0 1 1 1 1 Fic/DOC family HTH_34 PF13601.6 EFC44476.1 - 0.055 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Oxidored_q4 PF00507.19 EFC44476.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Arf PF00025.21 EFC44477.1 - 0.006 16.0 0.4 0.0094 15.4 0.4 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family EamA PF00892.20 EFC44478.1 - 3.5e-19 69.3 43.5 7.3e-12 45.6 19.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EFC44478.1 - 2.2e-15 56.8 24.1 2.7e-15 56.5 24.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EFC44478.1 - 0.038 13.2 30.1 0.039 13.2 24.2 2.4 1 1 1 2 2 2 0 UAA transporter family DnaJ PF00226.31 EFC44479.1 - 1e-19 70.4 0.2 1e-19 70.4 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain DUF3899 PF13038.6 EFC44479.1 - 0.45 11.1 1.4 0.55 10.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF3364 PF11844.8 EFC44479.1 - 5.6 7.3 10.6 0.35 11.2 1.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF3364) DUF4829 PF16111.5 EFC44479.1 - 6.9 7.5 12.2 0.22 12.3 4.5 2.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4829) TPR_12 PF13424.6 EFC44480.1 - 4.5e-05 23.7 1.8 0.4 11.0 0.0 2.8 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44480.1 - 0.00036 21.0 0.1 0.025 15.2 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44480.1 - 0.0018 18.2 6.3 0.13 12.4 0.2 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC44480.1 - 0.0024 17.9 0.2 0.1 12.7 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat UPF0181 PF03701.14 EFC44480.1 - 0.0076 15.9 0.3 0.02 14.5 0.1 1.8 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0181) MIT PF04212.18 EFC44480.1 - 0.013 15.5 0.1 0.87 9.7 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 EFC44480.1 - 0.014 15.2 0.4 6.1 6.9 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44480.1 - 0.026 15.0 0.4 0.16 12.5 0.4 2.2 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44480.1 - 0.047 14.4 0.1 6.6 7.5 0.2 2.2 1 1 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC44480.1 - 0.049 13.8 0.4 4.3 7.6 0.1 2.6 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFC44480.1 - 0.061 13.6 2.7 1.8 9.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFC44480.1 - 0.092 12.5 1.3 0.16 11.7 0.2 1.9 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_1 PF00515.28 EFC44480.1 - 0.31 10.9 0.0 0.31 10.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NST1 PF13945.6 EFC44482.1 - 0.44 10.6 7.1 0.4 10.8 6.4 1.3 1 1 0 1 1 1 0 Salt tolerance down-regulator MAP70 PF07058.11 EFC44482.1 - 7.5 5.2 6.2 8 5.1 6.2 1.0 1 0 0 1 1 1 0 Microtubule-associated protein 70 FSH1 PF03959.13 EFC44483.1 - 1.7e-25 90.0 0.0 3.9e-25 88.8 0.0 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) LRR_6 PF13516.6 EFC44485.1 - 1.5e-31 105.7 24.8 0.0035 17.3 0.1 10.3 10 0 0 10 10 10 8 Leucine Rich repeat LRR_8 PF13855.6 EFC44485.1 - 1.3e-19 69.6 42.8 7e-07 28.9 1.5 4.6 2 1 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC44485.1 - 2.3e-14 53.3 31.3 0.0019 18.5 0.1 6.0 2 2 6 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC44485.1 - 5.9e-07 29.2 14.9 14 6.7 0.1 8.8 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC44485.1 - 0.011 15.3 10.8 1.1 8.8 0.2 3.3 1 1 2 3 3 3 0 Leucine-rich repeat BAR_3 PF16746.5 EFC44485.1 - 0.092 12.4 4.9 0.04 13.6 1.1 2.2 3 0 0 3 3 3 0 BAR domain of APPL family RNA_pol_A_CTD PF03118.15 EFC44485.1 - 0.39 10.5 5.9 1.4 8.7 0.0 4.0 3 1 1 4 4 4 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF4116 PF13475.6 EFC44486.1 - 2.4e-56 187.2 23.9 2.1e-12 46.6 0.0 10.4 6 4 2 9 9 9 7 Domain of unknown function (DUF4116) Enterotoxin_b PF01376.18 EFC44486.1 - 0.1 12.8 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 Heat-labile enterotoxin beta chain MotCF PF09158.10 EFC44486.1 - 0.11 12.6 2.6 0.54 10.3 0.1 3.4 2 2 2 4 4 4 0 Bacteriophage T4 MotA, C-terminal Pkinase PF00069.25 EFC44487.1 - 1.9e-65 220.8 0.3 2.2e-65 220.7 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44487.1 - 2.7e-53 180.9 0.1 3.3e-53 180.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC44487.1 - 1.9e-06 27.4 0.1 4.4e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFC44487.1 - 2e-06 27.0 0.6 3.8e-06 26.1 0.6 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC44487.1 - 0.0092 14.8 0.0 0.013 14.3 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC44487.1 - 0.017 15.1 0.0 4.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family S4 PF01479.25 EFC44489.1 - 8.3e-13 47.8 0.9 2e-12 46.6 0.2 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 EFC44489.1 - 7.4e-05 23.6 0.8 7.4e-05 23.6 0.8 1.9 2 1 0 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain CheR_N PF03705.15 EFC44489.1 - 0.17 11.7 2.5 0.39 10.5 0.1 2.3 1 1 1 2 2 2 0 CheR methyltransferase, all-alpha domain LINES_C PF14695.6 EFC44490.1 - 4.6e-12 45.2 0.1 1.1e-11 44.0 0.1 1.7 1 0 0 1 1 1 1 Lines C-terminus LINES_N PF14694.6 EFC44490.1 - 1.1e-05 25.2 9.3 1.1e-05 25.2 9.3 2.0 1 1 0 1 1 1 1 Lines N-terminus SLATT_4 PF18186.1 EFC44491.1 - 0.051 13.2 0.1 0.094 12.4 0.1 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 PBC PF03792.13 EFC44491.1 - 0.13 12.0 5.2 0.078 12.7 3.1 1.7 2 0 0 2 2 2 0 PBC domain Pilin_N PF07790.11 EFC44492.1 - 0.073 14.0 1.4 0.68 10.9 0.2 2.7 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal LLGL PF08366.13 EFC44492.1 - 0.11 12.8 0.2 0.11 12.8 0.2 2.0 2 0 0 2 2 2 0 LLGL2 WYL_2 PF10902.8 EFC44492.1 - 5.1 7.5 5.2 1.2 9.5 0.9 2.1 2 0 0 2 2 2 0 WYL_2, Sm-like SH3 beta-barrel fold BTB_2 PF02214.22 EFC44494.1 - 1.2e-21 76.8 2.8 5.5e-13 49.1 0.1 3.6 3 1 0 3 3 3 2 BTB/POZ domain Polbeta PF18765.1 EFC44494.1 - 0.038 14.1 0.2 0.4 10.8 0.2 2.5 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase PGAP1 PF07819.13 EFC44495.1 - 0.002 17.9 0.0 0.0068 16.2 0.0 1.9 1 1 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 EFC44495.1 - 0.0094 16.6 0.0 0.013 16.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family IMS PF00817.20 EFC44496.1 - 7.2e-46 155.9 0.6 1.2e-44 151.9 0.2 2.4 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 EFC44496.1 - 1.2e-13 51.8 0.0 5.2e-13 49.7 0.0 2.1 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 EFC44496.1 - 1.5e-09 38.1 0.6 1.7e-08 34.7 0.0 3.0 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFC44496.1 - 2.5e-07 31.0 0.1 5.5e-06 26.7 0.0 3.3 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFC44496.1 - 0.00027 20.8 0.0 0.00078 19.3 0.0 1.9 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 EFC44496.1 - 0.00036 20.8 1.7 0.035 14.4 0.0 3.7 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain UPF0489 PF12640.7 EFC44496.1 - 0.062 13.5 0.9 1.1 9.4 0.0 3.1 2 1 0 3 3 3 0 UPF0489 domain IMS_HHH PF11798.8 EFC44496.1 - 0.077 13.4 0.0 0.35 11.3 0.0 2.1 1 0 0 1 1 1 0 IMS family HHH motif SAM_3 PF18016.1 EFC44496.1 - 0.12 12.2 1.1 0.21 11.4 0.2 1.9 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) RTT107_BRCT_5 PF16770.5 EFC44496.1 - 0.32 10.9 0.0 0.32 10.9 0.0 3.4 3 1 1 4 4 4 0 Regulator of Ty1 transposition protein 107 BRCT domain Serinc PF03348.15 EFC44496.1 - 0.57 9.1 5.9 0.049 12.5 0.7 1.9 2 0 0 2 2 2 0 Serine incorporator (Serinc) Ribosomal_L12_N PF16320.5 EFC44496.1 - 1.7 8.4 5.4 0.43 10.3 1.3 2.2 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain Phage_TAC_4 PF08748.11 EFC44496.1 - 2 8.7 14.1 0.87 9.9 1.3 3.3 3 1 0 3 3 3 0 Phage tail assembly chaperone SR-25 PF10500.9 EFC44496.1 - 5.6 6.5 20.2 3 7.4 8.0 3.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Arrestin_N PF00339.29 EFC44497.1 - 8.9e-10 38.8 0.0 8.6e-07 29.1 0.0 2.7 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFC44497.1 - 2.7e-06 27.9 0.1 2.7e-06 27.9 0.1 2.7 2 1 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Baculo_PEP_C PF04513.12 EFC44498.1 - 0.98 9.5 6.4 0.78 9.8 2.9 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPMT PF05724.11 EFC44499.1 - 2.8e-32 112.2 0.0 4.6e-32 111.4 0.0 1.3 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 EFC44499.1 - 7.1e-10 38.9 0.0 1.5e-09 37.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC44499.1 - 1.8e-07 31.8 0.0 2.6e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC44499.1 - 2e-07 31.6 0.0 3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC44499.1 - 1.7e-06 28.7 0.0 2.7e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC44499.1 - 0.0004 20.3 0.0 0.00074 19.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC44499.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DUF4116 PF13475.6 EFC44500.1 - 2.5e-140 456.1 18.8 3e-19 68.5 0.1 12.7 9 3 4 13 13 13 12 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC44500.1 - 5.9e-24 84.8 7.3 5.9e-24 84.8 7.3 2.4 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44500.1 - 7.4e-08 32.0 1.7 9.2e-08 31.7 0.2 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase AfsA PF03756.13 EFC44500.1 - 0.00037 20.5 0.0 6.3 6.8 0.0 4.0 2 2 2 4 4 4 2 A-factor biosynthesis hotdog domain Sen15 PF09631.10 EFC44500.1 - 0.03 14.6 1.3 9.5 6.6 0.0 3.6 3 1 0 3 3 3 0 Sen15 protein Kdo PF06293.14 EFC44500.1 - 0.042 13.2 0.4 0.1 11.9 0.4 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NYD-SP28_assoc PF14775.6 EFC44500.1 - 0.79 9.9 4.1 5.1 7.3 2.9 2.7 2 0 0 2 2 2 0 Sperm tail C-terminal domain AAA_22 PF13401.6 EFC44501.1 - 2.6e-06 27.7 0.0 5.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EFC44501.1 - 3.5e-05 23.8 0.0 7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 EFC44501.1 - 0.0012 18.7 0.0 0.0022 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 EFC44501.1 - 0.009 15.4 0.1 0.034 13.6 0.1 1.8 1 1 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 EFC44501.1 - 0.021 15.2 0.1 0.29 11.5 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 EFC44501.1 - 0.03 13.5 0.0 0.099 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFC44501.1 - 0.091 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Wx5_PLAF3D7 PF09688.10 EFC44501.1 - 0.15 12.1 1.4 0.36 10.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) Gaa1 PF04114.14 EFC44502.1 - 6.3e-50 170.6 23.2 2.3e-49 168.7 23.2 1.9 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component PK PF00224.21 EFC44503.1 - 1.4e-111 372.7 8.5 1.9e-111 372.4 8.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 EFC44503.1 - 8.6e-23 80.8 0.2 4.3e-22 78.6 0.1 2.3 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EFC44503.1 - 0.03 13.5 0.6 0.078 12.1 0.6 1.7 1 1 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family DUF4533 PF15047.6 EFC44504.1 - 0.013 15.0 2.5 0.95 9.0 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4533) ApoLp-III PF07464.11 EFC44504.1 - 0.19 11.8 11.6 8.1 6.5 0.5 4.6 3 2 1 4 4 4 0 Apolipophorin-III precursor (apoLp-III) MMR_HSR1 PF01926.23 EFC44505.1 - 0.0054 16.8 0.3 0.031 14.4 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase CAC1F_C PF16885.5 EFC44506.1 - 0.089 12.4 3.3 0.11 12.2 3.3 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Presenilin PF01080.17 EFC44506.1 - 0.25 10.1 0.8 0.24 10.1 0.8 1.1 1 0 0 1 1 1 0 Presenilin ESSS PF10183.9 EFC44506.1 - 0.33 11.2 2.0 3.3 8.0 1.3 2.3 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) TMEM43 PF07787.12 EFC44506.1 - 0.52 9.7 4.2 0.62 9.4 4.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 43 TPT PF03151.16 EFC44507.1 - 9e-21 74.5 26.4 1.1e-20 74.2 26.4 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC44507.1 - 3e-08 33.9 29.8 1.7e-06 28.3 15.4 3.0 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 EFC44507.1 - 0.00025 20.4 30.5 0.00042 19.6 30.5 1.5 1 1 0 1 1 1 1 UAA transporter family Ly-6_related PF06579.12 EFC44507.1 - 0.019 15.2 0.3 0.11 12.7 0.1 2.0 1 1 1 2 2 2 0 Caenorhabditis elegans ly-6-related protein DUF1129 PF06570.11 EFC44507.1 - 1.4 8.3 6.8 2 7.9 5.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) NST1 PF13945.6 EFC44508.1 - 4.3e-15 56.3 7.1 4.3e-15 56.3 7.1 7.0 2 2 4 7 7 7 1 Salt tolerance down-regulator DUF454 PF04304.13 EFC44508.1 - 0.11 12.5 0.2 0.21 11.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF454) MAPKK1_Int PF08923.10 EFC44509.1 - 8.8e-18 64.2 0.1 3e-17 62.5 0.1 1.8 1 1 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting DUF2570 PF10828.8 EFC44509.1 - 0.036 13.9 1.1 0.056 13.3 0.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) IZUMO PF15005.6 EFC44509.1 - 0.037 14.5 0.1 0.064 13.8 0.1 1.4 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated NuA4 PF09340.10 EFC44510.1 - 3.2e-21 75.0 5.1 4.8e-21 74.4 5.1 1.3 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 FAM104 PF15434.6 EFC44510.1 - 0.037 14.6 0.1 0.037 14.6 0.1 1.9 1 1 0 2 2 2 0 Family 104 PI3_PI4_kinase PF00454.27 EFC44511.1 - 1.9e-51 175.3 0.1 1.2e-34 120.3 0.0 2.8 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC44511.1 - 3e-51 173.4 4.8 3e-51 173.4 4.8 2.1 2 1 1 3 3 3 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3K_C2 PF00792.24 EFC44511.1 - 9.7e-21 74.2 0.0 3e-20 72.5 0.0 1.9 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 DUF4135 PF13575.6 EFC44511.1 - 0.0058 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) C2 PF00168.30 EFC44511.1 - 0.032 14.5 0.1 0.15 12.4 0.0 2.2 2 0 0 2 2 2 0 C2 domain Glyco_transf_4 PF13439.6 EFC44512.1 - 0.00055 20.0 0.0 0.00099 19.2 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase Family 4 CUE PF02845.16 EFC44513.1 - 1.3e-07 31.2 0.0 2.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 CUE domain HEAT PF02985.22 EFC44514.1 - 1.8e-18 65.0 8.5 0.0035 17.5 0.0 9.5 10 0 0 10 10 10 5 HEAT repeat HEAT_2 PF13646.6 EFC44514.1 - 9.7e-16 57.9 0.2 0.0028 18.0 0.0 6.5 5 2 1 6 6 6 3 HEAT repeats Adaptin_N PF01602.20 EFC44514.1 - 5.1e-06 25.3 3.5 0.098 11.2 0.0 3.4 1 1 0 2 2 2 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 EFC44514.1 - 1.6e-05 25.4 5.6 0.24 12.0 0.0 5.9 5 3 3 8 8 8 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFC44514.1 - 0.08 13.5 1.0 3.6 8.2 0.0 4.0 3 1 1 4 4 4 0 HEAT-like repeat F-box-like PF12937.7 EFC44515.1 - 4.1e-08 33.0 0.2 8e-08 32.1 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC44515.1 - 0.028 14.3 0.3 0.079 12.9 0.3 1.8 1 0 0 1 1 1 0 F-box domain F-box_5 PF18511.1 EFC44515.1 - 0.16 11.5 0.6 0.43 10.2 0.2 1.9 2 0 0 2 2 2 0 F-box GATA PF00320.27 EFC44516.1 - 1.4e-06 27.8 8.1 1.4e-06 27.8 8.1 3.2 2 1 0 2 2 2 1 GATA zinc finger PHD PF00628.29 EFC44516.1 - 0.00054 19.8 15.6 0.00054 19.8 15.6 2.7 2 0 0 2 2 2 1 PHD-finger C1_1 PF00130.22 EFC44516.1 - 0.018 14.9 12.7 0.018 14.9 12.7 3.0 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ndc1_Nup PF09531.10 EFC44516.1 - 1 7.9 4.7 1.4 7.5 4.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup 2TM PF13239.6 EFC44517.1 - 0.03 14.6 0.6 0.061 13.6 0.6 1.5 1 0 0 1 1 1 0 2TM domain TK PF00265.18 EFC44521.1 - 0.083 12.7 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Thymidine kinase Ras PF00071.22 EFC44522.1 - 5.7e-38 130.1 0.0 6.6e-38 129.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44522.1 - 7.4e-15 55.2 0.0 1.1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 EFC44523.1 - 2.6e-16 60.0 5.1 1.2e-15 57.9 5.1 2.2 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EFC44523.1 - 3e-08 33.7 4.8 3e-08 33.7 4.8 1.9 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFC44523.1 - 6.6e-08 32.7 3.1 6.6e-08 32.7 3.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EFC44523.1 - 1.5e-05 25.3 7.1 1.5e-05 25.3 7.1 5.2 5 2 2 7 7 7 2 Pleckstrin homology domain DUF3492 PF11997.8 EFC44523.1 - 0.1 12.3 3.0 0.3 10.8 3.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) PH_15 PF17339.2 EFC44523.1 - 0.13 12.1 1.6 0.33 10.9 1.6 1.6 1 0 0 1 1 1 0 PH domain PRR22 PF15776.5 EFC44523.1 - 0.24 10.7 1.6 0.4 10.0 1.6 1.3 1 0 0 1 1 1 0 Proline-rich protein family 22 CRA PF06589.11 EFC44524.1 - 0.27 11.4 4.8 0.06 13.4 1.4 1.7 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) Acetyltransf_1 PF00583.25 EFC44525.1 - 2.8e-14 53.3 0.0 4e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC44525.1 - 1.9e-12 47.2 0.0 2.5e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC44525.1 - 3.3e-10 40.2 0.0 4.9e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC44525.1 - 1e-08 35.0 0.0 1.7e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFC44525.1 - 5.6e-05 23.3 0.5 9e-05 22.6 0.2 1.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC44525.1 - 0.013 16.2 0.0 0.016 15.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC44525.1 - 0.021 14.3 0.5 0.028 13.9 0.5 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_9 PF13527.7 EFC44525.1 - 0.03 14.4 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFC44525.1 - 0.04 13.6 0.0 0.082 12.6 0.0 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DAD PF02109.16 EFC44526.1 - 5.4e-35 120.0 8.0 6.6e-35 119.7 8.0 1.1 1 0 0 1 1 1 1 DAD family DUF1129 PF06570.11 EFC44526.1 - 0.099 12.1 1.8 0.095 12.2 0.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Cyt_b-c1_8 PF10890.8 EFC44526.1 - 0.11 12.9 0.2 1.1 9.7 0.0 2.0 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 DUF2929 PF11151.8 EFC44526.1 - 0.84 10.0 8.3 1.1 9.6 1.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) FliP PF00813.20 EFC44527.1 - 0.046 13.6 0.1 0.068 13.0 0.1 1.4 1 1 0 1 1 1 0 FliP family DUF3589 PF12141.8 EFC44527.1 - 0.054 12.1 4.2 0.066 11.8 4.2 1.0 1 0 0 1 1 1 0 Beta-mannosyltransferases DUF5383 PF17355.2 EFC44527.1 - 0.057 13.8 3.2 0.1 12.9 2.2 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5383) tRNA_bind PF01588.20 EFC44528.1 - 1.3e-08 34.8 0.0 2.6e-08 33.8 0.0 1.6 2 0 0 2 2 2 1 Putative tRNA binding domain BPL_C PF02237.17 EFC44528.1 - 0.026 14.4 0.1 0.084 12.8 0.0 1.8 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain E1-E2_ATPase PF00122.20 EFC44528.1 - 0.13 11.8 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 E1-E2 ATPase RhoGEF PF00621.20 EFC44529.1 - 2.6e-36 125.5 16.6 2.6e-36 125.5 16.6 5.0 5 1 0 5 5 5 1 RhoGEF domain FerA PF08165.11 EFC44529.1 - 0.0044 16.9 1.4 0.0087 16.0 0.2 2.2 2 0 0 2 2 2 1 FerA (NUC095) domain TIR_2 PF13676.6 EFC44531.1 - 0.12 13.0 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 TIR domain LRR_6 PF13516.6 EFC44532.1 - 2.9e-23 79.9 22.0 2.4e-06 27.2 0.4 9.4 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.7 EFC44532.1 - 4.4e-08 33.3 26.8 0.032 14.7 3.3 6.6 4 2 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC44532.1 - 1e-06 28.4 5.0 7.2 7.6 0.0 8.2 8 0 0 8 8 8 1 Leucine Rich Repeat Sipho_Gp157 PF05565.11 EFC44532.1 - 0.042 13.9 8.9 0.097 12.7 8.5 1.9 1 1 0 1 1 1 0 Siphovirus Gp157 Baculo_PEP_C PF04513.12 EFC44532.1 - 0.36 10.9 19.1 0.24 11.5 0.6 4.3 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phasin PF05597.11 EFC44532.1 - 0.37 10.8 13.6 2.2 8.3 0.6 3.4 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Apolipoprotein PF01442.18 EFC44532.1 - 0.38 10.6 14.0 0.31 10.9 11.3 2.1 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 EFC44532.1 - 1.2 9.8 5.3 22 5.7 0.5 3.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 EFC44532.1 - 3.5 7.1 17.1 1 8.9 8.6 2.5 1 1 1 2 2 2 0 Exonuclease VII, large subunit Rrp15p PF07890.12 EFC44533.1 - 2.1e-07 31.4 4.4 2.1e-07 31.4 4.4 2.7 1 1 1 2 2 2 1 Rrp15p Peptidase_M28 PF04389.17 EFC44534.1 - 8.9e-12 45.1 0.0 1.4e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Nicastrin PF05450.15 EFC44534.1 - 0.00036 20.1 0.6 0.0019 17.7 0.6 2.2 1 1 0 1 1 1 1 Nicastrin LSM PF01423.22 EFC44535.1 - 1e-15 57.1 0.6 1.3e-15 56.8 0.6 1.2 1 0 0 1 1 1 1 LSM domain PhnA PF03831.14 EFC44535.1 - 0.011 15.6 0.2 2.4 8.1 0.1 2.2 2 0 0 2 2 2 0 PhnA domain Hfq PF17209.3 EFC44535.1 - 0.033 13.8 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Hfq protein MMR_HSR1 PF01926.23 EFC44537.1 - 1.1e-09 38.3 0.0 4e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Septin PF00735.18 EFC44537.1 - 1.9e-07 30.7 0.2 0.0035 16.7 0.1 2.4 1 1 1 2 2 2 2 Septin AIG1 PF04548.16 EFC44537.1 - 3.6e-06 26.5 0.2 0.0004 19.8 0.0 2.6 2 0 0 2 2 2 1 AIG1 family RsgA_GTPase PF03193.16 EFC44537.1 - 8.6e-06 25.8 0.1 0.0017 18.3 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EFC44537.1 - 3.8e-05 24.1 0.0 0.00017 22.0 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain TF_Zn_Ribbon PF08271.12 EFC44537.1 - 0.00019 20.9 2.4 0.00058 19.3 2.4 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding Dynamin_N PF00350.23 EFC44537.1 - 0.00054 20.1 0.4 0.003 17.6 0.4 2.4 1 1 0 1 1 1 1 Dynamin family Arf PF00025.21 EFC44537.1 - 0.0008 18.9 0.1 0.24 10.8 0.0 2.7 3 0 0 3 3 3 1 ADP-ribosylation factor family IIGP PF05049.13 EFC44537.1 - 0.0061 15.7 0.0 0.015 14.4 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) DUF815 PF05673.13 EFC44537.1 - 0.013 14.7 0.0 0.028 13.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EFC44537.1 - 0.013 14.6 0.0 0.033 13.3 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 EFC44537.1 - 0.02 15.4 0.0 0.064 13.8 0.0 1.9 2 0 0 2 2 1 0 ABC transporter FtsK_SpoIIIE PF01580.18 EFC44537.1 - 0.033 13.5 0.0 0.089 12.1 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF953 PF06110.11 EFC44537.1 - 0.033 13.8 0.7 0.1 12.2 0.7 1.8 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Herpes_UL14 PF03580.14 EFC44537.1 - 0.041 14.1 0.3 0.11 12.8 0.3 1.7 1 0 0 1 1 1 0 Herpesvirus UL14-like protein MMR_HSR1_Xtn PF16897.5 EFC44537.1 - 0.056 13.5 0.6 1 9.4 0.0 2.9 2 1 0 2 2 2 0 C-terminal region of MMR_HSR1 domain AAA_29 PF13555.6 EFC44537.1 - 0.058 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 EFC44537.1 - 0.061 12.9 0.2 6.4 6.3 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 EFC44537.1 - 0.064 13.0 0.9 19 5.0 0.0 3.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Zn_Tnp_IS1595 PF12760.7 EFC44537.1 - 0.066 13.2 0.8 0.14 12.1 0.8 1.6 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Ribosomal_S27e PF01667.17 EFC44537.1 - 0.068 12.9 0.6 0.14 11.9 0.6 1.4 1 0 0 1 1 1 0 Ribosomal protein S27 Zeta_toxin PF06414.12 EFC44537.1 - 0.12 11.6 0.0 0.27 10.5 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin DUF2387 PF09526.10 EFC44537.1 - 1.6 9.0 4.2 4.5 7.5 4.2 1.7 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) RhoGEF PF00621.20 EFC44538.1 - 8.5e-37 127.1 2.4 8.5e-37 127.1 2.4 4.8 2 1 1 4 4 4 2 RhoGEF domain SH3_1 PF00018.28 EFC44538.1 - 0.00016 21.2 0.2 0.0017 17.9 0.0 2.5 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 EFC44538.1 - 0.00043 19.9 0.0 0.00095 18.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 EFC44538.1 - 0.00052 19.8 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain HAP1_N PF04849.13 EFC44538.1 - 0.0057 15.9 7.0 0.0057 15.9 7.0 4.8 4 1 1 5 5 5 1 HAP1 N-terminal conserved region OrfB_IS605 PF01385.19 EFC44538.1 - 0.3 11.3 7.2 8.7 6.6 1.8 3.4 2 0 0 2 2 2 0 Probable transposase PKcGMP_CC PF16808.5 EFC44538.1 - 0.4 10.6 10.9 2.4 8.1 1.1 5.5 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SUB1_ProdP9 PF18213.1 EFC44538.1 - 2.1 8.2 7.9 5.9 6.8 2.4 3.8 3 0 0 3 3 3 0 SUB1 protease Prodomain ProdP9 RNase_PH PF01138.21 EFC44540.1 - 7.7e-39 133.2 0.0 1e-38 132.8 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFC44540.1 - 2e-09 37.4 0.0 3.8e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RAB3GAP2_N PF14655.6 EFC44541.1 - 9.6e-48 163.5 0.0 1.3e-47 163.0 0.0 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus TRL PF13146.6 EFC44541.1 - 0.072 13.4 0.4 2.5 8.5 0.1 2.5 2 0 0 2 2 2 0 TRL-like protein family MethyTransf_Reg PF10119.9 EFC44542.1 - 0.018 15.8 0.0 0.055 14.2 0.0 1.8 1 0 0 1 1 1 0 Predicted methyltransferase regulatory domain MMR_HSR1_Xtn PF16897.5 EFC44542.1 - 0.059 13.4 4.9 0.053 13.5 0.9 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain RCC1 PF00415.18 EFC44544.1 - 5.6e-14 52.5 4.7 8.8e-06 26.3 0.0 4.7 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC44544.1 - 1.6e-10 40.5 12.6 0.0031 17.3 1.2 4.3 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat DUF2862 PF11061.8 EFC44544.1 - 0.06 13.2 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2862) WaaY PF06176.11 EFC44544.1 - 0.12 12.0 0.2 0.12 12.0 0.2 1.5 2 0 0 2 2 2 0 Lipopolysaccharide core biosynthesis protein (WaaY) Kelch_6 PF13964.6 EFC44544.1 - 0.23 11.8 1.9 30 5.1 0.1 3.8 4 0 0 4 4 4 0 Kelch motif DIM1 PF02966.16 EFC44545.1 - 3.3e-66 221.1 0.6 3.7e-66 220.9 0.6 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EFC44545.1 - 3.9e-06 26.8 0.2 5.1e-06 26.4 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFC44545.1 - 0.061 13.7 0.1 0.091 13.1 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like GidB PF02527.15 EFC44545.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G EI24 PF07264.11 EFC44546.1 - 2.7e-32 112.4 11.0 3.4e-32 112.1 11.0 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) BTB_2 PF02214.22 EFC44548.1 - 1.4e-12 47.7 0.1 1.6e-12 47.6 0.1 1.0 1 0 0 1 1 1 1 BTB/POZ domain FAE1_CUT1_RppA PF08392.12 EFC44549.1 - 0.00042 19.7 0.8 0.0012 18.2 0.7 1.7 1 1 1 2 2 2 1 FAE1/Type III polyketide synthase-like protein Q_salvage PF10343.9 EFC44549.1 - 0.042 13.4 0.1 0.079 12.5 0.1 1.4 1 0 0 1 1 1 0 Potential Queuosine, Q, salvage protein family p450 PF00067.22 EFC44551.1 - 3.1e-15 55.9 0.0 4.1e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PAZ_siRNAbind PF12212.8 EFC44551.1 - 0.037 13.9 0.2 0.089 12.6 0.2 1.6 1 0 0 1 1 1 0 PAZ domain p450 PF00067.22 EFC44552.1 - 1.5e-33 116.3 0.1 1.7e-33 116.1 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cnd1 PF12717.7 EFC44553.1 - 3.9e-13 49.8 9.8 0.0012 18.9 1.7 5.3 3 1 1 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC44553.1 - 1.9e-11 44.2 0.6 2.8e-05 24.4 0.2 3.7 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 EFC44553.1 - 1.3e-07 31.2 4.2 5.5 7.5 0.0 7.2 7 0 0 7 7 7 2 HEAT repeat Vac14_Fab1_bd PF12755.7 EFC44553.1 - 1.7e-05 25.3 7.0 0.015 15.9 0.1 5.0 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region ArgoMid PF16487.5 EFC44553.1 - 0.11 12.7 0.0 6.1 7.2 0.0 3.3 2 0 0 2 2 2 0 Mid domain of argonaute DUF1837 PF08878.11 EFC44554.1 - 0.17 11.7 9.6 0.041 13.7 5.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) Ribosomal_60s PF00428.19 EFC44554.1 - 1.8 9.2 12.7 1.9 9.1 3.7 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein 2OG-FeII_Oxy_3 PF13640.6 EFC44555.1 - 1.2e-08 35.8 0.0 2.7e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1831 PF08866.10 EFC44555.1 - 0.0044 17.4 0.6 0.016 15.6 0.6 1.9 1 0 0 1 1 1 1 Putative amino acid metabolism RPN1_C PF18051.1 EFC44555.1 - 0.065 13.3 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal SUB1_ProdP9 PF18213.1 EFC44555.1 - 0.18 11.6 0.6 17 5.3 0.0 2.8 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 TRAM_LAG1_CLN8 PF03798.16 EFC44556.1 - 2.2e-27 96.1 28.5 2.6e-27 95.9 28.5 1.1 1 0 0 1 1 1 1 TLC domain DSPc PF00782.20 EFC44557.1 - 5.6e-08 32.7 0.0 7.7e-08 32.2 0.0 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC44557.1 - 7.6e-06 25.7 0.0 1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFC44557.1 - 0.0002 21.4 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family CDKN3 PF05706.12 EFC44557.1 - 0.0042 16.8 0.0 0.0052 16.5 0.0 1.1 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EFC44557.1 - 0.0082 16.3 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EFC44557.1 - 0.029 14.0 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Pkinase PF00069.25 EFC44558.1 - 4.6e-28 98.3 0.0 5e-28 98.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44558.1 - 2e-22 79.8 0.0 2.2e-22 79.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44558.1 - 0.00086 18.2 0.0 0.00091 18.1 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC44558.1 - 0.0016 17.8 0.0 0.0018 17.7 0.0 1.0 1 0 0 1 1 1 1 Kinase-like RGS PF00615.19 EFC44559.1 - 8.1e-08 32.5 3.9 8.1e-08 32.5 3.9 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF3387 PF11867.8 EFC44559.1 - 0.0074 15.7 1.0 0.015 14.7 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3387) Pkinase PF00069.25 EFC44560.1 - 1.1e-36 126.5 0.1 1.5e-36 126.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44560.1 - 2.9e-20 72.7 0.0 4e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44560.1 - 0.00038 19.3 0.0 0.0007 18.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC44560.1 - 0.018 15.0 0.0 0.73 9.7 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Acyl-CoA_dh_M PF02770.19 EFC44562.1 - 9.3e-10 38.6 0.0 1.6e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFC44562.1 - 0.00012 22.3 0.0 0.00048 20.3 0.0 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 EFC44562.1 - 0.0022 18.5 0.1 0.005 17.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Filamin PF00630.19 EFC44563.1 - 2.5e-73 243.5 14.9 9.3e-18 65.0 0.0 5.7 5 0 0 5 5 5 5 Filamin/ABP280 repeat RasGAP PF00616.19 EFC44563.1 - 6.1e-34 117.6 6.7 6.1e-34 117.6 6.7 3.4 3 1 1 4 4 3 1 GTPase-activator protein for Ras-like GTPase CH PF00307.31 EFC44563.1 - 5.4e-18 65.2 1.3 2.3e-17 63.1 0.0 2.9 3 0 0 3 3 2 1 Calponin homology (CH) domain Invasin_D3 PF09134.10 EFC44563.1 - 1.3e-17 63.8 19.1 9.7e-06 25.8 1.7 5.6 5 0 0 5 5 5 4 Invasin, domain 3 RasGAP_C PF03836.15 EFC44563.1 - 3.1e-17 63.0 12.6 3.1e-17 63.0 12.6 2.9 4 0 0 4 4 2 1 RasGAP C-terminus YtkA PF13115.6 EFC44563.1 - 1e-10 42.0 7.5 0.024 15.2 0.0 5.9 5 0 0 5 5 5 2 YtkA-like Y_Y_Y PF07495.13 EFC44563.1 - 4.6e-07 29.7 11.2 0.22 11.5 0.0 6.4 6 0 0 6 6 6 2 Y_Y_Y domain Cadherin_5 PF17892.1 EFC44563.1 - 0.0026 17.7 11.6 0.43 10.6 0.2 4.4 4 1 0 4 4 4 2 Cadherin-like domain CopC PF04234.12 EFC44563.1 - 0.0029 18.6 0.7 31 5.7 0.1 4.3 4 0 0 4 4 3 0 CopC domain DUF5060 PF16586.5 EFC44563.1 - 0.0031 17.9 0.0 2.5 8.6 0.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF5060) DUF5011 PF16403.5 EFC44563.1 - 0.0069 16.5 21.3 0.39 10.9 0.5 5.9 7 0 0 7 7 5 2 Domain of unknown function (DUF5011) Big_1 PF02369.16 EFC44563.1 - 0.0072 16.3 13.2 0.32 11.0 0.5 5.2 5 0 0 5 5 4 1 Bacterial Ig-like domain (group 1) PKD PF00801.20 EFC44563.1 - 0.029 14.2 1.6 29 4.6 0.0 4.2 4 0 0 4 4 4 0 PKD domain CAMSAP_CH PF11971.8 EFC44563.1 - 0.035 13.9 0.0 0.12 12.2 0.0 2.0 1 0 0 1 1 1 0 CAMSAP CH domain BclA_C PF18573.1 EFC44563.1 - 0.16 11.9 2.5 7.4 6.5 0.1 3.4 4 0 0 4 4 2 0 BclA C-terminal domain Glyco_hydro_30C PF17189.4 EFC44563.1 - 0.21 11.8 1.5 0.98 9.7 0.2 2.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 30 beta sandwich domain Aida_N PF08910.10 EFC44563.1 - 0.26 11.7 6.0 5.5 7.4 0.3 3.5 3 0 0 3 3 2 0 Aida N-terminus DUF2277 PF10041.9 EFC44563.1 - 0.28 11.5 1.2 3.8 7.9 0.1 3.0 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2277) CBM60 PF16841.5 EFC44563.1 - 0.31 11.5 5.6 0.28 11.6 0.3 3.5 4 0 0 4 4 4 0 Ca-dependent carbohydrate-binding module xylan-binding MG2 PF01835.19 EFC44563.1 - 0.77 10.3 4.1 38 4.8 0.1 4.2 5 0 0 5 5 5 0 MG2 domain ZapD PF07072.11 EFC44563.1 - 1.9 8.2 6.7 0.24 11.1 1.7 2.0 2 0 0 2 2 2 0 Cell division protein SpoOE-like PF09388.10 EFC44563.1 - 4 7.4 8.1 46 4.0 4.4 3.4 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein Big_3 PF07523.12 EFC44563.1 - 4.1 7.8 14.5 1.9 8.8 0.5 4.8 4 1 0 4 4 4 0 Bacterial Ig-like domain (group 3) Big_3_5 PF16640.5 EFC44563.1 - 4.2 7.6 9.5 14 6.0 0.3 4.2 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) Exonuc_VII_L PF02601.15 EFC44563.1 - 5.9 6.4 11.8 0.56 9.7 4.9 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF1541 PF07563.11 EFC44563.1 - 6.5 6.7 7.1 26 4.8 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) Big_6 PF17936.1 EFC44563.1 - 7.2 7.0 15.2 38 4.6 0.2 5.6 6 2 1 7 7 4 0 Bacterial Ig domain DUF5093 PF17011.5 EFC44565.1 - 0.057 13.7 0.3 0.091 13.0 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5093) DUF3067 PF11267.8 EFC44566.1 - 0.049 14.2 0.8 0.1 13.2 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3067) An_peroxidase PF03098.15 EFC44567.1 - 8.5e-110 367.8 0.0 9.8e-110 367.6 0.0 1.0 1 0 0 1 1 1 1 Animal haem peroxidase HSBP1 PF06825.12 EFC44568.1 - 0.0036 17.1 2.4 0.018 14.9 2.4 2.3 1 1 0 1 1 1 1 Heat shock factor binding protein 1 Vps5 PF09325.10 EFC44568.1 - 0.023 14.3 0.2 0.041 13.4 0.2 1.3 1 0 0 1 1 1 0 Vps5 C terminal like Nup54 PF13874.6 EFC44568.1 - 0.059 13.5 2.6 0.32 11.1 0.3 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 DUF3450 PF11932.8 EFC44568.1 - 1.3 8.3 4.9 0.13 11.5 0.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) FlaC_arch PF05377.11 EFC44568.1 - 1.5 9.3 7.4 0.46 10.9 2.4 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 EFC44568.1 - 6.6 6.8 12.1 1.4 9.0 1.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) XhlA PF10779.9 EFC44568.1 - 8.9 6.6 8.2 9.7 6.5 4.2 2.7 2 1 0 2 2 2 0 Haemolysin XhlA LSM PF01423.22 EFC44569.1 - 9.4e-22 76.5 1.2 1.2e-21 76.2 1.2 1.1 1 0 0 1 1 1 1 LSM domain RhoGAP PF00620.27 EFC44570.1 - 4.6e-45 153.1 0.1 1.5e-44 151.5 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain CTNNBL PF08216.11 EFC44570.1 - 0.59 10.3 5.0 0.53 10.5 1.1 2.7 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear TPR_1 PF00515.28 EFC44571.1 - 6.7e-29 98.5 6.3 4.3e-05 23.1 0.1 6.3 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44571.1 - 7.9e-24 81.8 1.9 0.0028 17.7 0.0 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44571.1 - 1.2e-11 44.4 0.2 0.31 11.8 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44571.1 - 5.8e-11 41.7 8.8 0.52 10.7 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44571.1 - 9e-11 41.9 5.8 0.00066 19.9 0.1 4.8 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44571.1 - 1.9e-10 40.3 1.6 0.0097 15.6 0.0 5.5 5 0 0 5 5 5 2 TPR repeat TPR_9 PF13371.6 EFC44571.1 - 3.1e-09 36.8 0.0 0.074 13.2 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC44571.1 - 1.9e-08 34.4 15.4 0.00019 21.6 6.0 5.3 2 1 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC44571.1 - 3.6e-07 30.6 0.2 0.12 12.9 0.0 5.2 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44571.1 - 2.1e-06 28.2 0.0 0.0077 16.9 0.0 4.1 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44571.1 - 2e-05 24.3 2.5 2.6 8.3 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 EFC44571.1 - 5.3e-05 22.8 2.7 0.0036 16.8 3.3 2.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 EFC44571.1 - 6.4e-05 22.7 0.0 0.77 9.7 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC44571.1 - 8.5e-05 22.7 6.1 4.2 8.0 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44571.1 - 9.5e-05 22.9 0.0 2.8 9.0 0.0 4.8 5 1 0 5 5 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC44571.1 - 0.00043 19.8 1.0 0.054 12.9 0.0 2.7 1 1 1 3 3 3 1 MalT-like TPR region T6SS_VasE PF05936.12 EFC44571.1 - 0.0039 16.0 0.2 0.071 11.8 0.0 2.1 2 0 0 2 2 2 1 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE TPR_15 PF13429.6 EFC44571.1 - 0.0055 15.9 0.2 0.92 8.7 0.1 3.2 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 EFC44571.1 - 0.0097 15.9 5.8 6 7.0 0.1 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 EFC44571.1 - 0.011 15.8 5.4 7.3 6.7 0.0 4.9 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 EFC44571.1 - 0.012 15.7 10.5 2.6 8.2 0.1 5.1 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat DUF3808 PF10300.9 EFC44571.1 - 0.018 13.8 0.9 0.018 13.8 0.9 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF3808) Pterin_4a PF01329.19 EFC44571.1 - 0.11 12.6 0.3 0.32 11.2 0.2 1.8 1 1 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase Desmo_N PF06771.11 EFC44571.1 - 0.17 12.3 3.4 6.8 7.1 0.0 3.9 3 1 1 4 4 4 0 Viral Desmoplakin N-terminus ACT_5 PF13710.6 EFC44572.1 - 0.0083 16.0 1.0 0.076 12.9 0.2 2.5 2 0 0 2 2 2 1 ACT domain RNase_H2-Ydr279 PF09468.10 EFC44572.1 - 0.05 13.8 1.3 0.19 11.9 0.0 2.5 3 0 0 3 3 3 0 Ydr279p protein family (RNase H2 complex component) wHTH domain WD40 PF00400.32 EFC44573.1 - 4.2e-09 36.9 0.6 0.0031 18.3 0.0 3.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC44573.1 - 1e-05 25.7 0.0 0.11 12.9 0.0 3.6 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC44573.1 - 0.044 12.7 0.1 0.19 10.6 0.0 1.8 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Actin PF00022.19 EFC44574.1 - 1.2e-144 481.9 0.0 5.3e-144 479.8 0.0 1.7 1 1 0 1 1 1 1 Actin ABC_membrane PF00664.23 EFC44575.1 - 1.3e-50 172.6 31.9 2e-29 103.1 16.8 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFC44575.1 - 5.4e-44 150.0 0.1 2.5e-21 76.6 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_29 PF13555.6 EFC44575.1 - 7.7e-07 28.8 1.0 0.019 14.7 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 EFC44575.1 - 9.6e-07 28.5 11.4 0.012 15.1 2.0 4.3 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC44575.1 - 2.3e-06 27.6 0.0 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 EFC44575.1 - 3e-06 27.5 1.0 0.058 13.5 0.1 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain MMR_HSR1 PF01926.23 EFC44575.1 - 1.7e-05 24.9 2.5 0.17 12.0 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC44575.1 - 3.6e-05 24.0 0.9 1.2 9.5 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EFC44575.1 - 0.0002 21.8 0.0 0.96 9.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain T2SSE PF00437.20 EFC44575.1 - 0.00028 20.0 0.0 0.32 10.0 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein Dynamin_N PF00350.23 EFC44575.1 - 0.00028 21.0 3.6 0.047 13.8 0.0 3.5 4 0 0 4 4 3 1 Dynamin family NB-ARC PF00931.22 EFC44575.1 - 0.00057 19.1 0.0 1 8.5 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_7 PF12775.7 EFC44575.1 - 0.00064 19.3 0.1 1.1 8.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 EFC44575.1 - 0.0063 16.6 0.3 6.3 6.8 0.0 3.7 2 1 1 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 EFC44575.1 - 0.0067 16.2 0.6 4.3 7.0 0.2 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_15 PF13175.6 EFC44575.1 - 0.0074 16.0 4.7 1.6 8.4 0.2 2.9 2 1 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 EFC44575.1 - 0.0082 16.1 0.3 4.6 7.1 0.1 2.5 2 0 0 2 2 2 1 NACHT domain FtsK_SpoIIIE PF01580.18 EFC44575.1 - 0.0083 15.5 1.1 1.3 8.4 0.1 2.8 3 0 0 3 3 3 1 FtsK/SpoIIIE family Roc PF08477.13 EFC44575.1 - 0.0085 16.3 0.1 14 5.9 0.0 3.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 EFC44575.1 - 0.0086 16.1 0.4 2.8 7.9 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Septin PF00735.18 EFC44575.1 - 0.0093 15.3 0.1 2.7 7.2 0.0 2.4 2 0 0 2 2 2 1 Septin AAA_25 PF13481.6 EFC44575.1 - 0.015 14.9 0.0 2.5 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain MeaB PF03308.16 EFC44575.1 - 0.016 14.2 0.0 5 6.0 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 EFC44575.1 - 0.023 14.4 0.1 7.8 6.2 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 EFC44575.1 - 0.042 13.1 0.9 1.4 8.1 0.0 3.0 3 0 0 3 3 3 0 Zeta toxin ATP-synt_ab PF00006.25 EFC44575.1 - 0.042 13.5 0.0 6.4 6.4 0.0 3.1 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.6 EFC44575.1 - 0.054 13.2 0.4 12 5.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFC44575.1 - 0.095 12.4 0.4 18 5.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 EFC44575.1 - 0.11 12.1 0.7 9.5 5.8 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 EFC44575.1 - 0.15 12.2 0.1 26 4.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 EFC44575.1 - 0.18 11.6 7.7 2.1 8.1 0.5 3.5 2 2 2 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Pox_A32 PF04665.12 EFC44575.1 - 0.2 11.1 2.3 1.1 8.7 0.1 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein AIG1 PF04548.16 EFC44575.1 - 0.23 10.8 1.2 3.5 6.9 0.1 2.5 2 0 0 2 2 2 0 AIG1 family AAA_23 PF13476.6 EFC44575.1 - 1 9.8 18.8 8.8 6.8 0.1 3.4 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 EFC44575.1 - 1.1 9.7 3.1 22 5.5 0.0 3.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Arf PF00025.21 EFC44576.1 - 1.1e-57 194.2 0.0 1.3e-57 194.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC44576.1 - 8.4e-10 38.4 0.0 1e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC44576.1 - 1.6e-07 30.8 1.0 0.0003 20.1 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC44576.1 - 3.8e-07 30.2 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFC44576.1 - 6e-06 26.5 0.0 9.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC44576.1 - 8.1e-06 25.4 0.0 9.9e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EFC44576.1 - 0.0004 20.1 0.0 0.00075 19.3 0.0 1.5 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 EFC44576.1 - 0.0011 18.5 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 Ras family Exo_endo_phos_2 PF14529.6 EFC44578.1 - 4.4e-05 23.3 0.7 4.4e-05 23.3 0.7 2.5 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Cast PF10174.9 EFC44578.1 - 0.00099 17.5 2.8 0.0013 17.0 2.8 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone L27 PF02828.16 EFC44578.1 - 0.067 13.0 0.3 0.16 11.8 0.3 1.6 1 0 0 1 1 1 0 L27 domain HTH_40 PF14493.6 EFC44578.1 - 0.41 11.1 4.7 13 6.3 0.0 3.5 4 0 0 4 4 4 0 Helix-turn-helix domain Mt_ATP-synt_D PF05873.12 EFC44578.1 - 0.56 10.0 6.3 0.36 10.7 3.3 2.2 1 1 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) HypA PF01155.19 EFC44579.1 - 0.1 12.6 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DHHC PF01529.20 EFC44580.1 - 4.4e-28 98.1 9.0 4.4e-28 98.1 9.0 2.5 3 0 0 3 3 3 1 DHHC palmitoyltransferase eIF-5a PF01287.20 EFC44580.1 - 1.1e-16 60.7 0.2 2e-16 59.8 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Zip PF02535.22 EFC44580.1 - 0.045 13.0 0.4 0.092 11.9 0.4 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter EFP_N PF08207.12 EFC44580.1 - 0.53 10.4 2.7 0.29 11.2 0.2 1.9 2 0 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain LRR_6 PF13516.6 EFC44581.1 - 2.3e-20 70.9 25.3 0.00026 20.8 0.0 9.3 10 0 0 10 10 10 6 Leucine Rich repeat LRR_4 PF12799.7 EFC44581.1 - 2.6e-19 69.0 37.6 1.3e-06 28.6 4.7 8.6 1 1 10 11 11 11 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC44581.1 - 2e-15 56.3 32.3 5e-08 32.6 2.7 7.2 2 2 5 8 8 8 6 Leucine rich repeat LRR_1 PF00560.33 EFC44581.1 - 6.4e-05 23.0 19.0 8.3 7.4 0.3 9.3 8 2 1 9 9 9 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC44581.1 - 0.0097 15.4 13.9 0.034 13.6 2.4 3.6 1 1 3 4 4 4 2 Leucine-rich repeat F-box-like PF12937.7 EFC44581.1 - 0.022 14.7 0.0 0.063 13.2 0.0 1.8 1 0 0 1 1 1 0 F-box-like Protoglobin PF11563.8 EFC44581.1 - 0.073 13.0 0.2 8 6.3 0.2 2.3 2 0 0 2 2 2 0 Protoglobin Beta_helix PF13229.6 EFC44581.1 - 2.5 7.9 6.5 0.57 10.0 2.2 2.0 2 1 0 2 2 2 0 Right handed beta helix region Trypsin_2 PF13365.6 EFC44582.1 - 0.0089 16.9 0.0 0.016 16.1 0.0 1.4 1 1 0 1 1 1 1 Trypsin-like peptidase domain dCache_1 PF02743.18 EFC44583.1 - 0.00099 19.0 7.8 0.00099 19.0 7.8 2.2 2 1 0 2 2 2 1 Cache domain Josephin PF02099.17 EFC44584.1 - 2.2e-49 167.7 0.1 2.9e-49 167.3 0.1 1.2 1 0 0 1 1 1 1 Josephin Glyoxalase PF00903.25 EFC44585.1 - 0.02 15.1 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C6 PF01681.17 EFC44585.1 - 9.4 6.8 13.1 2.2 8.8 0.7 2.9 1 1 1 3 3 3 0 C6 domain Sel1 PF08238.12 EFC44586.1 - 9.3e-48 159.6 25.9 2e-10 41.0 0.5 5.7 6 0 0 6 6 6 5 Sel1 repeat Pkinase PF00069.25 EFC44586.1 - 1.5e-39 136.0 1.6 1.5e-39 136.0 1.6 1.8 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44586.1 - 1.7e-26 93.0 0.8 3.6e-26 92.0 0.2 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase TPR_20 PF14561.6 EFC44586.1 - 6.5e-05 23.2 0.0 0.55 10.6 0.0 3.6 1 1 1 3 3 3 1 Tetratricopeptide repeat Haspin_kinase PF12330.8 EFC44586.1 - 0.0012 17.8 0.4 0.0012 17.8 0.4 2.4 2 1 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC44586.1 - 0.0079 15.0 0.1 0.02 13.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Phage_BR0599 PF09356.10 EFC44586.1 - 0.021 15.2 3.7 1.8 9.0 0.0 4.1 2 2 3 5 5 5 0 Phage conserved hypothetical protein BR0599 HEPN_Apea PF18739.1 EFC44586.1 - 0.29 11.6 7.7 1.2e+02 3.2 0.0 5.9 5 1 1 6 6 6 0 Apea-like HEPN TipAS PF07739.13 EFC44586.1 - 0.56 10.8 5.2 3.1 8.4 0.2 3.1 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain DUF4468 PF14730.6 EFC44586.1 - 0.95 9.8 10.9 5.4 7.4 0.0 5.6 7 0 0 7 7 7 0 Domain of unknown function (DUF4468) with TBP-like fold Sel1 PF08238.12 EFC44587.1 - 5.3e-62 204.9 35.7 2.6e-11 43.8 1.0 6.0 6 0 0 6 6 6 6 Sel1 repeat TPR_20 PF14561.6 EFC44587.1 - 8.6e-09 35.6 0.1 0.033 14.5 0.0 4.3 1 1 5 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44587.1 - 9.9e-07 29.0 10.6 0.18 12.1 1.0 5.9 1 1 5 6 6 6 3 Tetratricopeptide repeat Raptor_N PF14538.6 EFC44587.1 - 3.9e-06 26.9 1.9 0.2 11.6 0.2 4.1 1 1 3 4 4 4 2 Raptor N-terminal CASPase like domain HEPN_Apea PF18739.1 EFC44587.1 - 0.00088 19.7 10.3 26 5.3 0.1 5.6 3 2 3 6 6 6 0 Apea-like HEPN TPR_11 PF13414.6 EFC44587.1 - 0.0025 17.4 1.5 0.0025 17.4 1.5 6.9 7 2 0 7 7 7 1 TPR repeat TPR_6 PF13174.6 EFC44587.1 - 0.021 15.4 18.5 14 6.6 0.0 6.2 5 1 0 5 5 5 0 Tetratricopeptide repeat Ubiq-assoc PF09145.10 EFC44587.1 - 0.078 13.0 5.4 57 3.8 0.0 5.3 5 1 0 5 5 5 0 Ubiquitin-associated TerY_C PF15616.6 EFC44587.1 - 0.26 11.4 11.5 0.078 13.1 1.0 3.2 1 1 4 5 5 5 0 TerY-C metal binding domain Spore_III_AB PF09548.10 EFC44587.1 - 0.43 10.7 7.7 1.8 8.7 0.3 2.7 1 1 2 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) DUP PF00674.18 EFC44587.1 - 0.66 10.2 20.0 22 5.3 0.1 5.9 4 1 2 6 6 6 0 DUP family MIT PF04212.18 EFC44587.1 - 1.2 9.3 13.1 46 4.2 0.1 5.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain DUF2524 PF10732.9 EFC44587.1 - 1.5 9.1 17.5 16 5.9 0.3 5.4 5 1 1 6 6 6 0 Protein of unknown function (DUF2524) EcoEI_R_C PF08463.10 EFC44588.1 - 0.21 11.7 1.3 1.8 8.6 0.0 2.8 3 0 0 3 3 3 0 EcoEI R protein C-terminal FAM176 PF14851.6 EFC44589.1 - 0.11 12.2 1.3 0.23 11.1 1.3 1.7 1 1 0 1 1 1 0 FAM176 family EGF_2 PF07974.13 EFC44590.1 - 3.1e-06 27.4 74.7 0.0023 18.2 7.6 6.5 5 1 1 6 6 6 4 EGF-like domain Pectate_lyase_3 PF12708.7 EFC44590.1 - 4.2e-06 26.8 3.2 4.2e-06 26.8 3.2 3.0 2 1 2 4 4 4 1 Pectate lyase superfamily protein Cellulase PF00150.18 EFC44591.1 - 1e-05 25.2 0.0 3.2e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 EFC44591.1 - 0.016 14.9 0.1 0.03 13.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4038) CBM_11 PF03425.13 EFC44591.1 - 0.061 13.2 0.1 0.095 12.6 0.1 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Pkinase PF00069.25 EFC44592.1 - 9.3e-36 123.5 0.1 1.5e-24 86.8 0.0 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44592.1 - 9.5e-22 77.5 0.0 2.9e-15 56.3 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase PBD PF00786.28 EFC44592.1 - 0.084 13.3 0.4 0.25 11.7 0.4 1.8 1 0 0 1 1 1 0 P21-Rho-binding domain DUF505 PF04458.12 EFC44592.1 - 0.096 11.0 0.5 0.22 9.8 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF505) Pkinase_fungal PF17667.1 EFC44592.1 - 0.29 9.9 4.1 1 8.0 0.0 3.3 3 1 1 4 4 4 0 Fungal protein kinase Mcp5_PH PF12814.7 EFC44593.1 - 1e-05 25.6 0.0 3e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_12 PF16457.5 EFC44593.1 - 0.0022 18.5 0.1 0.0082 16.7 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Apt1 PF10351.9 EFC44594.1 - 0.00061 18.8 7.1 0.00061 18.8 7.1 2.3 2 0 0 2 2 2 1 Golgi-body localisation protein domain Podoplanin PF05808.11 EFC44594.1 - 1.4 9.0 15.7 0.034 14.2 2.3 2.5 2 1 0 2 2 2 0 Podoplanin CDP-OH_P_transf PF01066.21 EFC44595.1 - 7.6e-17 61.9 0.2 7.6e-17 61.9 0.2 3.8 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF1765 PF08578.10 EFC44595.1 - 1.1 9.7 7.4 0.81 10.2 1.3 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1765) Herpes_LMP1 PF05297.11 EFC44595.1 - 8.9 5.4 12.9 0.48 9.6 3.8 2.4 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) ANAPC4_WD40 PF12894.7 EFC44596.1 - 0.065 13.5 0.1 77 3.7 0.0 3.7 2 1 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DER1 PF04511.15 EFC44597.1 - 5.7e-42 143.8 8.2 6.4e-42 143.6 8.2 1.0 1 0 0 1 1 1 1 Der1-like family ABC2_membrane_5 PF13346.6 EFC44597.1 - 0.086 12.4 9.3 0.15 11.6 9.3 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein CTP-dep_RFKase PF01982.16 EFC44598.1 - 0.14 12.2 0.1 0.34 11.0 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function DUF120 Mago_nashi PF02792.14 EFC44599.1 - 9.9e-55 184.6 0.4 1.1e-54 184.4 0.4 1.0 1 0 0 1 1 1 1 Mago nashi protein DUF4419 PF14388.6 EFC44600.1 - 4.1e-102 341.7 0.8 4.6e-102 341.5 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) Sec7 PF01369.20 EFC44601.1 - 3.2e-61 206.2 0.7 1e-60 204.6 0.7 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 EFC44601.1 - 2.3e-42 144.6 5.8 2.3e-42 144.6 5.8 2.9 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 EFC44601.1 - 2.8e-35 121.6 3.3 2.8e-35 121.6 3.3 4.3 5 0 0 5 5 5 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF1981 PF09324.10 EFC44601.1 - 8.6e-26 89.6 10.5 1.1e-24 86.1 0.1 5.3 6 0 0 6 6 6 2 Domain of unknown function (DUF1981) FRG1 PF06229.12 EFC44602.1 - 5.4e-07 29.5 0.0 0.01 15.6 0.0 3.3 1 1 2 3 3 3 2 FRG1-like domain Fascin PF06268.13 EFC44602.1 - 0.00038 20.6 0.1 1.4 9.2 0.0 2.9 2 1 0 3 3 3 2 Fascin domain EF-hand_6 PF13405.6 EFC44602.1 - 0.0024 17.7 0.2 0.009 15.9 0.0 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EFC44602.1 - 0.018 14.9 0.0 0.041 13.7 0.0 1.6 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 EFC44602.1 - 0.019 14.5 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 EF hand Ins_allergen_rp PF06757.13 EFC44602.1 - 0.038 14.0 0.6 0.065 13.2 0.6 1.4 1 1 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification DUF4282 PF14110.6 EFC44603.1 - 0.00033 21.3 4.2 0.00045 20.9 4.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4282) Pex14_N PF04695.13 EFC44603.1 - 0.0038 17.9 1.1 0.0057 17.3 1.1 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Cytochrom_B_C PF00032.17 EFC44603.1 - 0.081 13.2 1.5 0.11 12.8 1.5 1.2 1 0 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD LysM PF01476.20 EFC44605.1 - 0.00091 19.2 0.0 0.021 14.9 0.0 2.4 2 0 0 2 2 2 1 LysM domain Mucin PF01456.17 EFC44605.1 - 0.0043 17.1 5.6 0.0064 16.5 5.6 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Chorion_3 PF05387.11 EFC44605.1 - 0.0043 16.7 0.7 0.0043 16.7 0.7 1.8 2 0 0 2 2 2 1 Chorion family 3 Herpes_capsid PF06112.11 EFC44605.1 - 0.43 10.6 21.9 0.9 9.6 21.9 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SSP160 PF06933.11 EFC44605.1 - 0.74 7.9 9.6 0.98 7.5 9.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Pkinase PF00069.25 EFC44606.1 - 3.9e-19 69.1 0.1 7.5e-19 68.1 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44606.1 - 7.1e-10 38.6 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_1 PF00515.28 EFC44606.1 - 3.4e-07 29.8 5.6 0.027 14.3 0.0 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat Kinase-like PF14531.6 EFC44606.1 - 7.7e-07 28.7 0.0 1.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like TPR_2 PF07719.17 EFC44606.1 - 2.2e-06 27.4 1.0 1.8 8.9 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44606.1 - 2.3e-05 24.3 11.9 0.03 14.5 0.0 5.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44606.1 - 0.00073 19.8 0.0 1.5 9.1 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Kdo PF06293.14 EFC44606.1 - 0.0047 16.3 0.0 0.009 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ANAPC3 PF12895.7 EFC44606.1 - 0.055 13.7 7.1 0.07 13.4 0.4 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC44606.1 - 0.15 12.6 0.1 10 6.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44607.1 - 1.7e-18 65.2 13.8 0.0096 16.0 0.4 7.1 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44607.1 - 1.1e-13 50.4 19.4 0.0063 16.3 0.1 6.9 6 1 1 7 7 7 4 Tetratricopeptide repeat Pkinase PF00069.25 EFC44607.1 - 1.2e-13 51.0 0.1 7.3e-13 48.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain TPR_12 PF13424.6 EFC44607.1 - 4e-11 43.0 5.2 0.01 16.1 0.2 5.1 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44607.1 - 7e-11 41.4 17.9 0.0076 16.4 0.7 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44607.1 - 8.6e-10 39.0 1.5 0.0093 16.5 0.0 5.3 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44607.1 - 6.7e-07 29.9 0.0 0.0036 17.9 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44607.1 - 1.2e-06 28.8 0.0 1.3 10.0 0.0 5.1 5 2 2 7 7 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44607.1 - 2.2e-06 27.9 2.7 0.25 12.0 0.0 5.3 6 0 0 6 6 4 1 Tetratricopeptide repeat Pkinase_Tyr PF07714.17 EFC44607.1 - 2.8e-06 26.8 0.1 8.4e-06 25.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase ANAPC3 PF12895.7 EFC44607.1 - 2.7e-05 24.3 14.4 0.3 11.3 0.7 4.5 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFC44607.1 - 3.1e-05 24.0 0.0 6.1 7.1 0.0 4.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44607.1 - 0.00034 20.4 0.2 10 6.4 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC44607.1 - 0.0021 18.3 7.2 0.59 10.6 0.1 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44607.1 - 0.0038 16.9 7.7 0.41 10.4 0.1 4.9 6 0 0 6 6 6 1 TPR repeat DUF1854 PF08909.11 EFC44607.1 - 0.043 13.6 0.4 0.089 12.6 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1854) DUF4810 PF16068.5 EFC44607.1 - 0.044 14.3 0.1 13 6.4 0.0 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4810) DUF5113 PF17140.4 EFC44607.1 - 0.58 9.9 8.6 2.8 7.7 1.0 3.9 2 2 2 4 4 4 0 Domain of unknown function (DUF5113) Guanylate_cyc PF00211.20 EFC44609.1 - 0.026 14.2 0.1 0.059 13.0 0.1 1.6 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Ribosomal_L4 PF00573.22 EFC44609.1 - 0.75 9.4 2.5 8.9 5.9 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L4/L1 family VirB3 PF05101.13 EFC44609.1 - 4.1 7.7 4.8 3.9 7.8 0.3 2.3 2 0 0 2 2 2 0 Type IV secretory pathway, VirB3-like protein His_Phos_2 PF00328.22 EFC44610.1 - 7.3e-15 55.2 0.1 1.1e-07 31.6 0.1 3.1 1 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 2) Spc7_C2 PF15577.6 EFC44610.1 - 0.082 13.0 0.1 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 Spc7_C2 Ras PF00071.22 EFC44611.1 - 1.4e-27 96.3 0.0 2.2e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44611.1 - 6.9e-22 77.9 0.0 1.2e-21 77.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC44611.1 - 1.6e-06 27.7 0.0 2.5e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFC44611.1 - 2.7e-06 26.9 0.0 3.8e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC44611.1 - 1e-05 25.2 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC44611.1 - 0.0014 18.7 0.0 0.0025 17.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFC44611.1 - 0.0046 16.2 2.1 0.15 11.2 2.1 2.1 1 1 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 EFC44611.1 - 0.014 15.3 0.0 0.053 13.4 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase ATP_bind_1 PF03029.17 EFC44611.1 - 0.021 14.6 0.0 0.04 13.7 0.0 1.7 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein Dpy-30 PF05186.13 EFC44611.1 - 0.15 11.8 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Dpy-30 motif Pkinase PF00069.25 EFC44612.1 - 1.1e-48 165.9 0.1 1.2e-48 165.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44612.1 - 2.2e-47 161.5 0.0 2.4e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC44612.1 - 7e-05 22.3 0.0 8.5e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFC44612.1 - 0.0006 18.9 0.0 0.0013 17.8 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC44612.1 - 0.024 13.4 0.1 0.031 13.1 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 EFC44612.1 - 0.031 13.6 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC44612.1 - 0.035 14.0 0.0 0.058 13.3 0.0 1.3 1 1 0 1 1 1 0 Phosphotransferase enzyme family RCC1 PF00415.18 EFC44613.1 - 1.9e-26 92.4 3.9 2.8e-07 31.0 0.1 6.7 6 2 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC44613.1 - 4.4e-17 61.4 13.2 0.00028 20.6 0.1 6.4 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Mcl1_mid PF12341.8 EFC44613.1 - 0.0066 15.8 0.0 0.069 12.5 0.0 2.3 1 1 0 1 1 1 1 Minichromosome loss protein, Mcl1, middle region RdRP PF05183.12 EFC44614.1 - 1.7e-152 509.1 2.0 2.6e-152 508.5 2.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase Syntaxin_2 PF14523.6 EFC44615.1 - 0.0045 17.3 3.6 0.32 11.4 0.4 2.1 1 1 0 2 2 2 2 Syntaxin-like protein Lge1 PF11488.8 EFC44615.1 - 0.083 13.1 0.7 0.28 11.4 0.7 1.9 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 Transglut_core PF01841.19 EFC44617.1 - 2e-07 31.5 0.2 1.7e-05 25.2 0.2 2.2 1 1 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 EFC44617.1 - 0.0051 16.4 0.1 0.0074 15.8 0.1 1.2 1 0 0 1 1 1 1 Transglutaminase-like domain RNA_pol_Rpb4 PF03874.16 EFC44617.1 - 0.14 12.5 0.6 0.24 11.7 0.1 1.5 1 1 0 1 1 1 0 RNA polymerase Rpb4 PagP PF07017.11 EFC44618.1 - 0.1 12.0 0.2 0.18 11.2 0.2 1.5 1 1 0 1 1 1 0 Antimicrobial peptide resistance and lipid A acylation protein PagP PARG_cat PF05028.14 EFC44619.1 - 8.3e-12 45.0 0.0 2.2e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 Poly (ADP-ribose) glycohydrolase (PARG) Myosin_TH1 PF06017.13 EFC44620.1 - 0.00024 20.8 0.2 0.00043 20.0 0.2 1.5 1 1 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Uteroglobin PF01099.17 EFC44620.1 - 0.17 12.3 0.0 0.29 11.5 0.0 1.3 1 0 0 1 1 1 0 Uteroglobin family PTPLA PF04387.14 EFC44621.1 - 3.1e-35 121.3 0.7 5.5e-35 120.5 0.7 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA PSP1 PF04468.12 EFC44622.1 - 0.021 15.1 0.6 0.13 12.5 0.2 2.4 2 1 0 2 2 2 0 PSP1 C-terminal conserved region RIH_assoc PF08454.11 EFC44622.1 - 0.25 11.2 3.4 5.3 6.9 0.6 2.4 2 0 0 2 2 2 0 RyR and IP3R Homology associated Cation_efflux PF01545.21 EFC44623.1 - 5.4e-21 75.2 9.8 7.7e-21 74.7 9.8 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 EFC44623.1 - 1.6e-12 47.4 0.2 3.2e-12 46.4 0.2 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Rax2 PF12768.7 EFC44624.1 - 0.1 12.1 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF3980 PF13140.6 EFC44624.1 - 0.1 13.0 0.5 0.1 13.0 0.5 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3980) Guanylate_cyc PF00211.20 EFC44625.1 - 3.3e-57 193.1 0.9 6.5e-57 192.1 0.9 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC44625.1 - 1.1e-14 54.6 0.3 2.9e-14 53.2 0.1 1.9 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC44625.1 - 1.6e-05 24.9 0.0 3.5e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC44625.1 - 0.003 17.8 0.0 0.006 16.8 0.0 1.5 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC44625.1 - 0.0032 16.9 0.1 0.0069 15.8 0.1 1.6 1 0 0 1 1 1 1 Heme NO binding associated DUF2970 PF11174.8 EFC44625.1 - 5.9 6.8 8.6 0.11 12.3 0.3 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2970) Patatin PF01734.22 EFC44626.1 - 6.2e-17 62.4 0.0 1.1e-16 61.7 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase SR-25 PF10500.9 EFC44626.1 - 3.2 7.3 18.8 3.7 7.1 1.5 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein LRR_8 PF13855.6 EFC44627.1 - 3e-25 87.7 40.0 4.6e-11 42.3 0.7 5.3 4 1 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC44627.1 - 1.1e-20 73.4 42.1 7e-05 23.1 0.2 7.7 2 2 6 9 9 9 8 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC44627.1 - 2.5e-17 61.4 27.4 0.0021 18.0 0.5 9.7 10 0 0 10 10 10 5 Leucine Rich repeat LRR_9 PF14580.6 EFC44627.1 - 4.5e-09 36.1 13.4 0.0038 16.7 4.1 3.2 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 EFC44627.1 - 8e-06 25.7 24.5 3.4 8.6 0.2 9.3 9 1 0 9 9 9 3 Leucine Rich Repeat F-box-like PF12937.7 EFC44627.1 - 0.0065 16.3 0.1 0.018 15.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC44627.1 - 0.019 14.8 0.5 0.06 13.2 0.1 2.1 2 0 0 2 2 2 0 F-box domain DUF4508 PF14969.6 EFC44628.1 - 0.019 15.2 1.2 1 9.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4508) Adenosine_kin PF04008.14 EFC44629.1 - 2.1e-74 248.5 0.1 2.4e-74 248.3 0.1 1.0 1 0 0 1 1 1 1 Adenosine specific kinase FAM104 PF15434.6 EFC44630.1 - 0.96 10.0 6.4 4.8 7.8 3.6 2.4 2 0 0 2 2 2 0 Family 104 2OG-FeII_Oxy_2 PF13532.6 EFC44631.1 - 2.5e-40 138.8 0.2 3e-40 138.5 0.2 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4402 PF14352.6 EFC44631.1 - 0.032 14.9 0.1 0.076 13.7 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4402) Nucleoporin2 PF04096.14 EFC44633.1 - 2.8e-34 118.4 1.2 4.4e-34 117.7 0.0 2.0 2 0 0 2 2 2 1 Nucleoporin autopeptidase RGS PF00615.19 EFC44634.1 - 6.2e-10 39.4 5.5 1.8e-09 37.9 5.5 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain Mito_carr PF00153.27 EFC44636.1 - 5.2e-21 74.4 0.0 1.3e-13 50.7 0.2 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Phage_F PF02305.17 EFC44636.1 - 0.027 13.2 0.1 0.031 13.0 0.1 1.0 1 0 0 1 1 1 0 Capsid protein (F protein) DnaJ_C PF01556.18 EFC44637.1 - 1.8e-34 119.0 0.1 2.4e-34 118.5 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFC44637.1 - 1.1e-22 79.9 1.7 1.8e-22 79.2 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFC44637.1 - 6.6e-11 42.4 16.9 1.4e-10 41.4 16.9 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFC44637.1 - 0.00099 19.0 19.5 0.0059 16.5 5.0 2.4 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 EFC44637.1 - 4.6 7.3 11.8 8.2 6.5 2.1 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 EFC44637.1 - 9.5 6.3 9.9 58 3.8 9.9 2.0 1 1 0 1 1 1 0 zinc-ribbons zf-C3HC4_3 PF13920.6 EFC44638.1 - 3.3e-09 36.5 10.6 5.1e-09 35.9 10.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC44638.1 - 1.7e-08 34.3 10.9 2.8e-08 33.6 10.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 EFC44638.1 - 8.4e-08 32.4 12.7 1.3e-07 31.8 12.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 EFC44638.1 - 3.8e-06 26.8 11.8 8.1e-06 25.8 11.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFC44638.1 - 2.7e-05 23.9 10.1 6.3e-05 22.7 10.1 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFC44638.1 - 3e-05 23.8 13.7 5.7e-05 22.9 13.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC44638.1 - 0.0012 18.7 12.6 0.0024 17.7 12.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFC44638.1 - 0.0024 17.7 3.2 0.0046 16.8 3.2 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 EFC44638.1 - 0.0074 16.1 9.3 0.016 15.0 9.3 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain DUF1079 PF06435.11 EFC44638.1 - 0.067 13.4 2.8 0.34 11.2 0.3 2.7 3 0 0 3 3 3 0 Repeat of unknown function (DUF1079) zf-rbx1 PF12678.7 EFC44638.1 - 0.18 12.1 10.3 0.38 11.1 10.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 EFC44638.1 - 0.19 11.9 7.9 0.34 11.1 7.9 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 EFC44638.1 - 0.49 10.2 8.2 1.2 9.0 8.2 1.7 1 0 0 1 1 1 0 RING-like zinc finger DUF1272 PF06906.11 EFC44638.1 - 0.71 10.0 7.5 1.2 9.2 7.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) IBR PF01485.21 EFC44638.1 - 0.82 9.9 10.4 30 5.0 10.5 2.5 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C3HC4_4 PF15227.6 EFC44638.1 - 0.96 9.7 11.5 3.3 8.0 11.6 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 EFC44638.1 - 1.5 8.1 16.1 2.3 7.5 15.3 2.0 1 1 0 1 1 1 0 Rtf2 RING-finger Geminin PF07412.12 EFC44639.1 - 0.028 14.2 1.7 0.056 13.2 0.0 2.0 2 0 0 2 2 2 0 Geminin BPL_LplA_LipB PF03099.19 EFC44639.1 - 0.038 13.9 0.0 0.087 12.7 0.0 1.6 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family VCBS PF13517.6 EFC44640.1 - 4.4e-21 75.2 18.5 4.2e-09 36.9 0.6 5.8 5 0 0 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 EFC44640.1 - 5.5e-17 61.6 15.5 6.4e-05 23.0 0.4 6.8 6 0 0 6 6 6 5 FG-GAP repeat PQQ_2 PF13360.6 EFC44640.1 - 3.5e-07 30.0 1.5 0.00078 19.1 0.0 2.8 2 1 1 3 3 3 2 PQQ-like domain BBS2_Mid PF14783.6 EFC44640.1 - 4.3e-07 29.9 1.5 2.5 8.2 0.0 5.9 6 1 0 6 6 6 2 Ciliary BBSome complex subunit 2, middle region Itfg2 PF15907.5 EFC44640.1 - 5.2e-07 29.0 6.4 0.22 10.5 0.1 5.4 5 2 0 5 5 5 3 Integrin-alpha FG-GAP repeat-containing protein 2 TcdB_toxin_midN PF12256.8 EFC44640.1 - 6.8e-06 25.6 1.4 0.15 11.5 0.0 5.0 5 0 0 5 5 5 1 Insecticide toxin TcdB middle/N-terminal region PQQ PF01011.21 EFC44640.1 - 8.2e-06 25.5 7.4 0.29 11.2 0.0 6.0 7 0 0 7 7 7 2 PQQ enzyme repeat PQQ_3 PF13570.6 EFC44640.1 - 0.00035 20.9 11.6 0.05 14.1 0.9 5.1 6 0 0 6 6 6 2 PQQ-like domain PliI PF16743.5 EFC44640.1 - 0.047 13.5 3.1 30 4.4 0.1 4.5 3 1 1 4 4 4 0 Periplasmic lysozyme inhibitor of I-type lysozyme DUF1712 PF08217.11 EFC44641.1 - 6.2e-34 117.5 4.5 4.2e-27 94.9 0.4 2.2 1 1 1 2 2 2 2 Fungal domain of unknown function (DUF1712) DUF3113 PF11310.8 EFC44641.1 - 0.015 15.2 0.4 4 7.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3113) HIT PF01230.23 EFC44642.1 - 4.8e-23 81.8 0.0 5.6e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 EFC44642.1 - 4.2e-19 69.1 0.0 5e-19 68.9 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Ribosomal_S17 PF00366.20 EFC44643.1 - 1.1e-19 70.3 1.8 1.8e-19 69.6 1.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S17 DUF1189 PF06691.11 EFC44643.1 - 0.2 11.2 2.1 0.28 10.7 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) E1-E2_ATPase PF00122.20 EFC44644.1 - 2.9e-49 167.0 0.4 2.9e-49 167.0 0.4 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFC44644.1 - 9.8e-45 152.5 3.4 9.8e-45 152.5 3.4 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFC44644.1 - 6.5e-23 82.1 1.0 1.7e-22 80.8 1.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC44644.1 - 2e-22 79.1 0.1 5.4e-22 77.7 0.1 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC44644.1 - 1.4e-14 53.5 0.0 2.6e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC44644.1 - 5.4e-06 26.3 0.6 0.0017 18.2 0.9 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 EFC44644.1 - 0.014 15.4 0.0 0.05 13.7 0.0 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase HAD PF12710.7 EFC44644.1 - 0.035 14.5 0.0 0.1 13.0 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1394 PF07159.12 EFC44646.1 - 1.1e-13 51.1 3.3 8.7e-12 44.9 3.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1394) WASH-7_N PF14745.6 EFC44646.1 - 0.00024 19.8 1.9 0.001 17.7 1.9 1.9 1 1 0 1 1 1 1 WASH complex subunit 7, N-terminal DNA_ligase_A_M PF01068.21 EFC44646.1 - 0.034 13.8 0.2 0.06 13.0 0.2 1.5 1 0 0 1 1 1 0 ATP dependent DNA ligase domain FTCD_C PF04961.12 EFC44646.1 - 0.05 13.4 0.7 0.12 12.1 0.3 1.7 1 1 0 1 1 1 0 Formiminotransferase-cyclodeaminase 2OG-FeII_Oxy_3 PF13640.6 EFC44647.1 - 2.7e-08 34.6 0.2 6.2e-08 33.4 0.2 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SWC7 PF17330.2 EFC44647.1 - 0.088 12.9 0.0 0.53 10.4 0.0 2.4 1 0 0 1 1 1 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 SDA1 PF05285.12 EFC44647.1 - 0.42 10.0 30.4 0.19 11.2 24.1 2.3 2 0 0 2 2 2 0 SDA1 Presenilin PF01080.17 EFC44647.1 - 2.1 7.0 8.1 3.5 6.3 8.1 1.3 1 0 0 1 1 1 0 Presenilin CAP PF00188.26 EFC44648.1 - 3.3e-16 60.3 4.3 4.3e-16 59.9 4.3 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SGL PF08450.12 EFC44649.1 - 0.00022 20.9 0.0 0.0018 17.9 0.0 2.0 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EFC44649.1 - 0.0029 17.6 0.9 4.4 7.5 0.0 4.4 5 0 0 5 5 5 1 NHL repeat DevR PF01905.16 EFC44649.1 - 0.048 12.7 0.0 0.068 12.2 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 TSNR_N PF04705.12 EFC44649.1 - 0.089 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus p25-alpha PF05517.12 EFC44650.1 - 7.1e-10 39.3 0.1 8.1e-06 26.1 0.1 2.3 2 0 0 2 2 2 2 p25-alpha NPR1_interact PF15699.5 EFC44650.1 - 2 9.1 6.5 0.38 11.4 1.9 2.1 2 0 0 2 2 2 0 NPR1 interacting PGM_PMM_I PF02878.16 EFC44651.1 - 6.7e-35 119.8 0.0 1.7e-34 118.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EFC44651.1 - 9.9e-20 71.1 0.0 2.9e-19 69.6 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFC44651.1 - 8.1e-14 51.8 0.1 1.4e-13 51.0 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 EFC44651.1 - 7.9e-10 38.8 0.0 2.6e-09 37.1 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain eIF2A PF08662.11 EFC44652.1 - 5e-12 46.1 1.7 0.0014 18.5 0.0 5.1 1 1 5 6 6 6 4 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EFC44652.1 - 1.1e-10 41.7 1.8 0.019 15.3 0.0 5.5 4 3 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC44652.1 - 4.4e-10 40.0 11.6 0.015 16.1 0.0 7.9 8 1 1 9 9 9 2 WD domain, G-beta repeat Lactonase PF10282.9 EFC44652.1 - 0.0012 18.1 0.0 0.25 10.6 0.0 2.4 1 1 0 2 2 2 2 Lactonase, 7-bladed beta-propeller PD40 PF07676.12 EFC44652.1 - 0.01 15.8 1.8 19 5.3 0.1 4.4 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat IKI3 PF04762.12 EFC44652.1 - 0.074 11.0 2.7 1.8 6.4 0.2 2.8 1 1 2 3 3 3 0 IKI3 family SGL PF08450.12 EFC44652.1 - 0.1 12.1 0.2 29 4.1 0.0 3.2 4 0 0 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region Kelch_2 PF07646.15 EFC44652.1 - 0.44 10.6 2.4 6.3 7.0 0.1 3.5 3 0 0 3 3 3 0 Kelch motif Proteasome_A_N PF10584.9 EFC44652.1 - 6 6.6 11.4 14 5.5 0.2 5.3 5 1 1 6 6 6 0 Proteasome subunit A N-terminal signature MA3 PF02847.17 EFC44653.1 - 8.4e-24 83.7 4.6 1.5e-23 82.9 3.2 2.2 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 EFC44653.1 - 3e-16 59.7 4.0 3e-16 59.7 4.0 2.0 2 1 0 2 2 2 1 MIF4G domain CARD PF00619.21 EFC44653.1 - 0.071 13.1 0.9 31 4.7 0.0 4.1 4 0 0 4 4 4 0 Caspase recruitment domain RTP PF02334.16 EFC44654.1 - 0.15 12.7 2.1 0.4 11.3 0.2 2.7 3 0 0 3 3 3 0 Replication terminator protein Pkinase PF00069.25 EFC44657.1 - 1.7e-35 122.7 1.4 3.7e-35 121.6 1.4 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44657.1 - 5.7e-19 68.4 0.3 1.3e-18 67.2 0.3 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Sulfotransfer_1 PF00685.27 EFC44657.1 - 0.045 13.2 0.4 0.39 10.1 0.1 2.3 2 0 0 2 2 2 0 Sulfotransferase domain zf-UBR PF02207.20 EFC44657.1 - 0.052 13.7 12.4 0.17 12.1 12.4 1.9 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 EFC44657.1 - 0.13 12.4 14.0 0.072 13.3 10.7 2.2 2 0 0 2 2 2 0 B-box zinc finger Nucleoporin_FG PF13634.6 EFC44658.1 - 0.021 15.7 37.9 0.021 15.7 37.9 4.4 2 1 2 4 4 4 0 Nucleoporin FG repeat region CLASP_N PF12348.8 EFC44658.1 - 0.032 13.8 0.4 0.058 13.0 0.4 1.3 1 0 0 1 1 1 0 CLASP N terminal IQ PF00612.27 EFC44661.1 - 1.8e-25 86.3 43.1 0.00014 21.3 0.1 18.5 21 0 0 21 21 21 8 IQ calmodulin-binding motif ASH PF15780.5 EFC44661.1 - 4.4e-05 23.6 0.0 0.00014 22.0 0.0 1.9 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin MapZ_C2 PF18708.1 EFC44661.1 - 0.035 14.4 0.3 20 5.6 0.0 3.6 3 0 0 3 3 3 0 MapZ extracellular C-terminal domain 2 DKNYY PF13644.6 EFC44661.1 - 0.51 11.1 5.0 27 5.5 0.0 3.5 3 0 0 3 3 3 0 DKNYY family Utp12 PF04003.12 EFC44661.1 - 4.6 7.6 9.1 0.89 9.9 1.8 3.6 3 0 0 3 3 3 0 Dip2/Utp12 Family RGS PF00615.19 EFC44662.1 - 4.5e-05 23.7 2.1 0.0099 16.1 2.1 2.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain PFOR_II PF17147.4 EFC44662.1 - 0.06 13.7 0.0 2.9 8.3 0.0 2.4 2 0 0 2 2 2 0 Pyruvate:ferredoxin oxidoreductase core domain II DUF4116 PF13475.6 EFC44663.1 - 2.4e-54 180.9 38.7 9.2e-10 38.1 0.5 10.9 7 3 3 11 11 11 11 Domain of unknown function (DUF4116) DUF4116 PF13475.6 EFC44665.1 - 5.6e-29 99.6 12.3 1.1e-13 50.7 0.3 6.2 2 2 3 6 6 6 6 Domain of unknown function (DUF4116) Pox_A3L PF05288.11 EFC44665.1 - 0.16 12.0 4.4 1.1 9.3 0.2 3.9 3 2 0 3 3 3 0 Poxvirus A3L Protein Ribonuclease_3 PF00636.26 EFC44666.1 - 3.5e-30 104.7 1.3 8.5e-15 55.3 0.2 3.0 2 1 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFC44666.1 - 6.5e-26 91.0 0.8 1.1e-15 57.9 0.0 3.1 2 0 0 2 2 2 2 Ribonuclease-III-like ResIII PF04851.15 EFC44666.1 - 4.6e-18 65.8 4.0 8.2e-18 65.0 0.0 3.1 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC44666.1 - 4.1e-15 56.1 0.6 4.1e-15 56.1 0.6 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC44666.1 - 4.2e-14 52.7 0.1 4.1e-13 49.5 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 EFC44666.1 - 0.0018 18.5 0.2 0.076 13.3 0.1 3.2 2 1 0 2 2 2 1 AAA domain DUF87 PF01935.17 EFC44666.1 - 0.55 10.3 5.0 15 5.6 0.0 3.8 4 0 0 4 4 4 0 Helicase HerA, central domain Pkinase PF00069.25 EFC44669.1 - 2.6e-58 197.4 4.4 3e-58 197.3 4.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44669.1 - 4.9e-33 114.5 0.7 6.3e-33 114.2 0.7 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44669.1 - 1e-08 34.4 0.0 2.3e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFC44669.1 - 0.0015 18.1 0.3 0.0015 18.1 0.3 2.3 2 1 0 3 3 3 1 PhoP regulatory network protein YrbL RIO1 PF01163.22 EFC44669.1 - 0.0078 15.8 2.5 0.0078 15.8 2.5 2.0 2 1 0 2 2 2 1 RIO1 family Kdo PF06293.14 EFC44669.1 - 0.0094 15.3 0.1 0.017 14.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family XRN1_D2_D3 PF18334.1 EFC44669.1 - 0.056 13.7 0.3 0.5 10.6 0.0 2.5 2 1 1 3 3 3 0 Exoribonuclease Xrn1 D2/D3 domain APH PF01636.23 EFC44669.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB PF00651.31 EFC44670.1 - 6.6e-05 23.1 0.8 0.00017 21.8 0.8 1.7 1 0 0 1 1 1 1 BTB/POZ domain Vps16_C PF04840.12 EFC44670.1 - 0.0033 16.5 3.0 0.044 12.8 0.2 2.3 2 1 0 2 2 2 2 Vps16, C-terminal region Nanovirus_coat PF04660.12 EFC44670.1 - 0.12 12.4 0.2 6.7 6.7 0.0 2.3 2 0 0 2 2 2 0 Nanovirus coat protein BTB_2 PF02214.22 EFC44671.1 - 4.8e-15 55.7 0.2 6.1e-08 32.9 0.0 3.4 3 0 0 3 3 3 2 BTB/POZ domain 2OG-FeII_Oxy_3 PF13640.6 EFC44671.1 - 6.2e-08 33.4 0.0 1.8e-07 31.9 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LUC7 PF03194.15 EFC44671.1 - 0.0017 18.1 7.0 0.064 12.9 1.6 2.6 2 0 0 2 2 2 2 LUC7 N_terminus DUF3828 PF12883.7 EFC44671.1 - 0.033 14.5 0.4 0.033 14.5 0.4 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3828) DUF3685 PF12452.8 EFC44671.1 - 0.059 13.1 0.5 0.27 10.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3685) RhoGAP PF00620.27 EFC44672.1 - 3.8e-41 140.4 0.1 1.1e-40 138.9 0.1 1.8 1 0 0 1 1 1 1 RhoGAP domain Herpes_UL69 PF05459.12 EFC44672.1 - 0.022 14.1 3.6 0.056 12.8 3.1 1.9 1 1 1 2 2 2 0 Herpesvirus transcriptional regulator family MtrG PF04210.13 EFC44672.1 - 0.12 12.3 0.9 0.47 10.4 0.0 2.4 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G GAGA_bind PF06217.12 EFC44672.1 - 4.2 7.6 8.9 93 3.1 8.9 2.5 1 1 0 1 1 1 0 GAGA binding protein-like family Glutaredoxin PF00462.24 EFC44673.1 - 1.4e-09 38.0 0.1 7e-09 35.8 0.0 2.0 1 1 1 2 2 2 1 Glutaredoxin SH3BGR PF04908.15 EFC44673.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.7 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein DUF1132 PF06575.12 EFC44674.1 - 0.016 15.6 4.5 0.29 11.5 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1132) DUF2347 PF09804.9 EFC44675.1 - 9e-41 140.3 1.2 9e-41 140.3 1.2 1.6 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 EFC44675.1 - 4.2e-13 48.7 10.7 1.1e-07 30.9 2.9 2.8 2 1 0 2 2 2 2 Transport protein Avl9 SPA PF08616.10 EFC44675.1 - 9e-05 22.4 0.7 0.00021 21.2 0.2 1.8 2 0 0 2 2 2 1 Stabilization of polarity axis Protoglobin PF11563.8 EFC44676.1 - 2.8e-44 150.8 0.4 3.2e-44 150.6 0.4 1.0 1 0 0 1 1 1 1 Protoglobin Cytochrom_B561 PF03188.16 EFC44679.1 - 3e-10 40.4 10.5 3e-10 40.4 10.5 2.3 2 1 0 2 2 2 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 EFC44679.1 - 0.016 15.3 10.8 1.6 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) DUF1418 PF07214.12 EFC44679.1 - 0.24 11.3 2.9 0.75 9.7 2.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) DUF998 PF06197.13 EFC44679.1 - 0.88 9.1 14.1 0.048 13.2 6.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF998) DUF3180 PF11377.8 EFC44679.1 - 0.9 9.7 7.2 10 6.2 2.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3180) DUF4116 PF13475.6 EFC44680.1 - 1.8e-61 203.7 12.0 2.1e-17 62.6 0.0 6.8 5 2 2 7 7 7 6 Domain of unknown function (DUF4116) AAA_18 PF13238.6 EFC44680.1 - 0.0086 16.6 0.2 0.0086 16.6 0.2 2.7 2 2 1 3 3 3 1 AAA domain CENP-B_dimeris PF09026.10 EFC44680.1 - 0.059 13.8 8.9 0.13 12.6 8.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.11 EFC44680.1 - 0.67 8.0 3.1 1 7.4 3.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MDM10 PF12519.8 EFC44680.1 - 2.1 7.1 6.2 3.9 6.2 6.2 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CUE PF02845.16 EFC44681.1 - 0.0078 15.9 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 1 CUE domain E3_UbLigase_EDD PF11547.8 EFC44681.1 - 0.029 14.0 0.1 0.054 13.2 0.1 1.4 1 0 0 1 1 1 0 E3 ubiquitin ligase EDD PX PF00787.24 EFC44682.1 - 0.00089 19.2 0.2 0.003 17.5 0.2 1.9 1 0 0 1 1 1 1 PX domain NPV_P10 PF05531.12 EFC44682.1 - 0.0077 16.7 10.1 0.58 10.7 0.4 3.3 3 1 0 3 3 3 2 Nucleopolyhedrovirus P10 protein SRF-TF PF00319.18 EFC44682.1 - 0.054 13.0 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 SRF-type transcription factor (DNA-binding and dimerisation domain) GlutR_dimer PF00745.20 EFC44682.1 - 0.15 12.5 0.0 0.15 12.5 0.0 3.1 4 1 0 4 4 4 0 Glutamyl-tRNAGlu reductase, dimerisation domain DASH_Duo1 PF08651.10 EFC44682.1 - 0.66 9.8 6.4 0.19 11.5 0.2 3.1 3 0 0 3 3 3 0 DASH complex subunit Duo1 Fzo_mitofusin PF04799.13 EFC44682.1 - 0.8 9.2 7.4 3.8 7.0 0.4 3.0 2 1 1 3 3 3 0 fzo-like conserved region Menin PF05053.13 EFC44682.1 - 1.6 7.0 11.9 0.061 11.7 4.8 1.9 2 0 0 2 2 2 0 Menin SAD_SRA PF02182.17 EFC44683.1 - 0.00099 18.8 0.1 0.00099 18.8 0.1 2.5 3 1 0 3 3 3 1 SAD/SRA domain Psu PF07455.11 EFC44683.1 - 0.36 10.4 3.1 0.48 10.0 2.1 1.7 2 0 0 2 2 2 0 Phage polarity suppression protein (Psu) Ndc1_Nup PF09531.10 EFC44683.1 - 0.86 8.2 4.7 0.97 8.0 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RRP36 PF06102.12 EFC44684.1 - 3.1e-30 105.3 25.8 3.1e-30 105.3 25.8 2.6 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 HTH_38 PF13936.6 EFC44684.1 - 0.039 13.7 3.5 6.3 6.6 0.1 3.7 4 0 0 4 4 4 0 Helix-turn-helix domain Sporozoite_P67 PF05642.11 EFC44684.1 - 1.8 6.5 14.1 3.3 5.7 14.1 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BCL_N PF04714.13 EFC44684.1 - 2.2 8.4 7.1 0.17 12.0 1.2 2.2 2 0 0 2 2 2 0 BCL7, N-terminal conserver region BRCA-2_helical PF09169.10 EFC44685.1 - 0.084 12.5 0.2 0.11 12.1 0.2 1.1 1 0 0 1 1 1 0 BRCA2, helical CTP_transf_like PF01467.26 EFC44686.1 - 4e-08 33.6 0.1 1.7e-07 31.5 0.1 2.1 1 1 0 1 1 1 1 Cytidylyltransferase-like DUF1235 PF06822.12 EFC44686.1 - 0.0022 17.3 0.2 0.0049 16.2 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1235) FAD_syn PF06574.12 EFC44686.1 - 0.072 13.0 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 FAD synthetase TPR_1 PF00515.28 EFC44687.1 - 1e-07 31.5 4.3 2.4e-06 27.1 0.5 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44687.1 - 4.3e-06 26.5 1.7 4.5e-05 23.3 0.2 3.7 4 0 0 4 4 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44687.1 - 8e-05 22.5 2.8 0.00042 20.2 0.1 3.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44687.1 - 0.00023 21.4 0.0 0.0025 18.1 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC44687.1 - 0.00083 19.1 1.6 0.0022 17.8 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC44687.1 - 0.01 15.5 0.6 0.2 11.4 0.0 3.1 3 0 0 3 3 3 0 TPR repeat TPR_19 PF14559.6 EFC44687.1 - 0.01 16.3 0.2 0.1 13.1 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR_2 PF13041.6 EFC44687.1 - 0.012 15.8 1.2 8.3 6.7 0.0 3.7 3 0 0 3 3 3 0 PPR repeat family SNAP PF14938.6 EFC44687.1 - 0.015 14.8 4.8 0.082 12.3 1.4 2.8 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 EFC44687.1 - 0.02 14.9 0.0 0.22 11.6 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44687.1 - 0.024 15.4 0.0 0.41 11.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC44687.1 - 0.2 12.1 0.8 2.8 8.5 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat EB1 PF03271.17 EFC44689.1 - 2.4e-14 53.3 1.6 5.9e-14 52.0 1.6 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 EFC44689.1 - 5.8e-10 39.3 0.3 1.4e-09 38.0 0.0 1.8 2 0 0 2 2 2 1 Calponin homology (CH) domain dUTPase PF00692.19 EFC44689.1 - 0.00029 20.5 0.1 0.81 9.4 0.0 2.4 3 0 0 3 3 3 2 dUTPase CAMSAP_CH PF11971.8 EFC44689.1 - 0.0014 18.4 1.0 0.005 16.6 0.0 2.3 3 0 0 3 3 3 1 CAMSAP CH domain CH_2 PF06294.11 EFC44689.1 - 0.011 15.8 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 0 CH-like domain in sperm protein BCL9 PF11502.8 EFC44689.1 - 0.02 14.7 0.4 0.54 10.1 0.1 2.3 2 0 0 2 2 2 0 B-cell lymphoma 9 protein SUIM_assoc PF16619.5 EFC44689.1 - 0.042 13.9 0.3 0.091 12.8 0.3 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 APG6_N PF17675.1 EFC44689.1 - 2 8.9 7.0 1.8 9.1 3.9 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region BTB PF00651.31 EFC44690.1 - 3.4e-05 24.0 0.1 0.00012 22.3 0.1 2.0 1 1 0 1 1 1 1 BTB/POZ domain NUDIX PF00293.28 EFC44691.1 - 8.3e-13 48.5 0.0 1.4e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Nudix_hydro PF18290.1 EFC44691.1 - 9.5e-13 48.0 0.8 6.8e-12 45.2 0.8 2.2 1 1 0 1 1 1 1 Nudix hydrolase domain Apolipoprotein PF01442.18 EFC44694.1 - 1.9e-10 41.0 61.1 0.0008 19.3 5.9 6.3 2 1 5 7 7 7 5 Apolipoprotein A1/A4/E domain HSBP1 PF06825.12 EFC44694.1 - 2.4e-06 27.3 31.0 0.51 10.2 0.1 9.7 8 1 0 8 8 8 3 Heat shock factor binding protein 1 TetR_C_27 PF17935.1 EFC44694.1 - 0.00085 19.4 1.3 2 8.5 0.0 3.9 3 0 0 3 3 3 2 Tetracyclin repressor-like, C-terminal domain DUF885 PF05960.11 EFC44694.1 - 0.0029 17.3 18.5 0.13 11.8 5.3 3.4 2 1 1 3 3 3 2 Bacterial protein of unknown function (DUF885) DUF465 PF04325.13 EFC44694.1 - 0.01 15.8 6.1 1.6 8.9 0.8 4.4 3 0 0 3 3 3 0 Protein of unknown function (DUF465) ApoLp-III PF07464.11 EFC44694.1 - 0.063 13.4 134.4 0.11 12.5 1.3 10.6 3 2 7 11 11 11 0 Apolipophorin-III precursor (apoLp-III) DUF1816 PF08846.10 EFC44694.1 - 0.071 13.1 0.7 6 7.0 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1816) ATP-synt_F PF01990.17 EFC44694.1 - 0.11 12.8 12.6 0.89 9.9 1.1 4.5 3 1 0 3 3 3 0 ATP synthase (F/14-kDa) subunit B2 PF11473.8 EFC44694.1 - 0.11 12.2 5.1 3.7 7.4 0.0 5.0 5 0 0 5 5 5 0 RNA binding protein B2 VBS PF08913.10 EFC44694.1 - 0.25 11.8 14.2 0.85 10.1 0.1 5.6 5 1 1 6 6 6 0 Vinculin Binding Site YfhE PF14152.6 EFC44694.1 - 0.74 9.9 6.9 0.7 10.0 0.1 3.7 3 0 0 3 3 3 0 YfhE-like protein Cytochrom_B562 PF07361.11 EFC44694.1 - 4.6 7.9 56.3 0.65 10.7 2.0 8.7 5 3 5 10 10 10 0 Cytochrome b562 Myosin_head PF00063.21 EFC44695.1 - 3.5e-73 247.0 24.3 9.2e-72 242.3 24.3 3.0 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 EFC44695.1 - 0.032 14.6 0.0 0.074 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 EFC44695.1 - 0.068 13.3 0.1 0.42 10.7 0.1 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Vps51 PF08700.11 EFC44696.1 - 1e-22 80.0 4.0 1e-22 80.0 4.0 4.5 4 1 1 5 5 5 1 Vps51/Vps67 Sec5 PF15469.6 EFC44696.1 - 1.7e-14 54.1 11.6 1.7e-14 54.1 11.6 2.5 2 0 0 2 2 2 1 Exocyst complex component Sec5 Dor1 PF04124.12 EFC44696.1 - 5e-13 48.4 11.9 5e-13 48.4 11.9 2.5 3 1 0 3 3 3 1 Dor1-like family Vps54_N PF10475.9 EFC44696.1 - 1.3e-07 31.2 12.9 1.3e-07 31.2 12.9 2.2 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 EFC44696.1 - 4.4e-05 23.6 4.7 4.4e-05 23.6 4.7 3.0 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 EFC44696.1 - 0.00097 19.3 6.0 0.00097 19.3 6.0 2.9 3 0 0 3 3 3 1 Golgi transport complex subunit 5 DUF948 PF06103.11 EFC44696.1 - 0.0095 16.2 1.9 0.05 13.9 1.4 2.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) APS_kinase PF01583.20 EFC44696.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase DASH_Dad2 PF08654.10 EFC44696.1 - 0.17 12.3 3.9 27 5.3 0.5 4.2 3 1 0 3 3 3 0 DASH complex subunit Dad2 Sec8_exocyst PF04048.14 EFC44696.1 - 1.9 8.4 12.8 0.21 11.5 4.8 3.2 4 0 0 4 4 4 0 Sec8 exocyst complex component specific domain DUF2115 PF09888.9 EFC44696.1 - 2.8 8.4 17.2 0.26 11.8 5.1 3.8 2 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2115) CENP-F_leu_zip PF10473.9 EFC44696.1 - 5.5 7.0 22.2 0.074 13.1 11.5 3.4 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bPH_3 PF14470.6 EFC44697.1 - 0.12 12.8 0.1 0.38 11.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial PH domain Hydrolase_4 PF12146.8 EFC44697.1 - 0.18 11.0 0.0 0.41 9.9 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 HMG_box PF00505.19 EFC44698.1 - 3e-11 43.6 3.8 9e-11 42.0 3.8 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC44698.1 - 0.00038 21.0 3.8 0.00038 21.0 3.8 1.9 2 0 0 2 2 2 1 HMG-box domain CHDNT PF08073.12 EFC44698.1 - 0.0036 17.2 0.3 0.011 15.7 0.3 1.8 1 0 0 1 1 1 1 CHDNT (NUC034) domain TPR_1 PF00515.28 EFC44699.1 - 4.2e-14 51.7 8.8 0.0039 16.9 0.2 5.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC44699.1 - 4.8e-12 45.0 4.4 0.42 10.8 0.1 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44699.1 - 1.2e-10 41.5 3.6 0.00031 21.0 0.1 3.6 2 1 2 4 4 4 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC44699.1 - 2.7e-08 33.9 11.7 1.7e-05 25.0 1.8 3.3 1 1 3 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 EFC44699.1 - 4e-07 29.7 4.2 0.66 10.3 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44699.1 - 5.7e-06 26.7 1.2 0.024 15.1 0.6 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC44699.1 - 2.2e-05 25.0 0.0 0.89 10.3 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC44699.1 - 0.00012 22.5 5.7 1.8 9.4 0.1 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat NARP1 PF12569.8 EFC44699.1 - 0.00036 19.6 0.1 0.0013 17.7 0.0 1.8 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 SRP_TPR_like PF17004.5 EFC44699.1 - 0.00052 20.0 3.3 0.0085 16.1 1.7 2.6 1 1 2 3 3 3 2 Putative TPR-like repeat MIT PF04212.18 EFC44699.1 - 0.0088 16.1 0.4 0.88 9.7 0.5 3.1 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 EFC44699.1 - 0.014 15.7 3.0 59 4.4 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat FapA PF03961.13 EFC44699.1 - 0.029 13.0 1.8 0.041 12.5 1.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TPR_7 PF13176.6 EFC44699.1 - 0.038 14.0 3.6 4.2 7.6 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC44699.1 - 0.14 12.3 0.1 3.5 7.8 0.0 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 EFC44699.1 - 0.19 11.8 0.4 19 5.3 0.0 3.1 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) DUF4116 PF13475.6 EFC44700.1 - 6.4e-15 54.6 15.4 1.3e-05 24.8 2.8 5.1 5 1 0 5 5 4 3 Domain of unknown function (DUF4116) F-box PF00646.33 EFC44700.1 - 3.3e-05 23.6 0.2 0.00014 21.6 0.2 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC44700.1 - 0.00011 22.0 0.0 0.00034 20.4 0.0 1.8 1 0 0 1 1 1 1 F-box-like RNA_pol_Rpc4 PF05132.14 EFC44700.1 - 0.0087 16.5 0.4 0.014 15.8 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 Nop14 PF04147.12 EFC44700.1 - 0.017 13.4 28.2 0.025 12.8 28.2 1.1 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.12 EFC44700.1 - 0.064 11.7 26.1 0.099 11.1 26.1 1.2 1 0 0 1 1 1 0 Mpp10 protein DUF913 PF06025.12 EFC44700.1 - 0.1 11.6 8.8 0.17 10.8 8.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Drc1-Sld2 PF11719.8 EFC44700.1 - 0.17 11.4 11.2 0.26 10.8 11.2 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein Astro_capsid_p PF12226.8 EFC44700.1 - 0.19 10.8 19.8 0.34 10.0 19.8 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CDC45 PF02724.14 EFC44700.1 - 0.2 9.9 20.7 0.3 9.4 20.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 EFC44700.1 - 0.35 10.3 28.5 0.55 9.6 28.5 1.2 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 EFC44700.1 - 0.66 9.9 12.0 1.6 8.6 12.0 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 EFC44700.1 - 0.87 7.6 38.1 1.5 6.8 38.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 EFC44700.1 - 0.95 8.8 30.5 1.5 8.2 30.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM60A PF15396.6 EFC44700.1 - 2.1 8.3 5.9 5.6 6.9 5.9 1.7 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 EFC44700.1 - 2.5 6.8 8.7 3.8 6.2 8.7 1.1 1 0 0 1 1 1 0 Presenilin DUF5523 PF17661.1 EFC44700.1 - 2.9 7.5 19.3 5.2 6.7 19.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) CPSF100_C PF13299.6 EFC44700.1 - 4.9 7.3 9.9 10 6.3 9.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 EFC44700.1 - 5.9 4.7 13.1 8.2 4.2 13.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 EFC44700.1 - 6.5 7.0 14.9 19 5.5 15.0 1.7 2 0 0 2 2 1 0 AAA-ATPase Vps4-associated protein 1 Tim54 PF11711.8 EFC44700.1 - 9.7 4.9 11.0 16 4.1 11.0 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNase_T PF00929.24 EFC44702.1 - 1.4e-13 51.7 0.1 1.7e-13 51.4 0.1 1.1 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EFC44702.1 - 0.0016 18.2 0.7 0.0022 17.7 0.7 1.2 1 0 0 1 1 1 1 3'-5' exonuclease Orthopox_A47 PF06334.11 EFC44702.1 - 0.0085 15.4 0.5 0.0092 15.3 0.5 1.2 1 0 0 1 1 1 1 Orthopoxvirus A47 protein BTB PF00651.31 EFC44703.1 - 4.2e-17 62.4 0.4 1.2e-16 60.9 0.1 1.9 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 EFC44703.1 - 3.4e-07 30.3 0.2 1.2e-06 28.6 0.1 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF3342 PF11822.8 EFC44703.1 - 0.00028 21.0 0.5 0.0054 16.9 0.2 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF3342) Syntaxin-6_N PF09177.11 EFC44703.1 - 0.094 13.3 0.2 0.4 11.3 0.2 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Pkinase PF00069.25 EFC44704.1 - 6e-24 84.8 0.0 7.5e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44704.1 - 2.1e-14 53.4 0.0 3e-14 52.9 0.0 1.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC44704.1 - 0.0053 16.1 0.0 0.0068 15.8 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 EFC44704.1 - 0.045 12.7 0.0 0.05 12.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 EFC44704.1 - 0.12 11.7 0.0 1.2 8.4 0.0 2.0 1 1 0 1 1 1 0 Kinase-like MMR_HSR1 PF01926.23 EFC44707.1 - 1.6e-09 37.8 0.0 6e-09 36.0 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC44707.1 - 4.2e-06 26.8 0.2 0.00038 20.4 0.2 2.8 2 0 0 2 2 2 1 RsgA GTPase DUF815 PF05673.13 EFC44707.1 - 5.9e-05 22.3 0.1 0.00012 21.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Septin PF00735.18 EFC44707.1 - 0.00026 20.4 4.9 0.2 10.9 0.0 3.3 2 1 1 3 3 3 2 Septin AAA_16 PF13191.6 EFC44707.1 - 0.0015 18.9 0.0 0.0032 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 EFC44707.1 - 0.0017 17.7 0.0 0.008 15.5 0.0 2.2 2 0 0 2 2 2 1 AIG1 family AAA_29 PF13555.6 EFC44707.1 - 0.0019 17.9 0.2 0.0045 16.7 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain G-alpha PF00503.20 EFC44707.1 - 0.0029 16.8 5.0 0.051 12.7 0.2 2.7 3 0 0 3 3 3 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC44707.1 - 0.0029 17.0 0.6 0.021 14.2 0.6 2.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 EFC44707.1 - 0.0051 16.2 0.2 0.014 14.8 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family T2SSE PF00437.20 EFC44707.1 - 0.013 14.6 0.0 0.027 13.5 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein Dynamin_N PF00350.23 EFC44707.1 - 0.014 15.5 3.1 0.017 15.2 0.2 2.5 2 1 0 2 2 2 0 Dynamin family TniB PF05621.11 EFC44707.1 - 0.027 13.9 0.0 0.062 12.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 EFC44707.1 - 0.034 14.7 0.5 0.034 14.7 0.5 2.5 2 2 1 3 3 3 0 ABC transporter Lar_restr_allev PF14354.6 EFC44707.1 - 0.042 14.2 1.5 0.13 12.7 1.5 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar YhfH PF14149.6 EFC44707.1 - 0.043 13.8 0.5 0.12 12.4 0.5 1.7 1 0 0 1 1 1 0 YhfH-like protein GTP_EFTU PF00009.27 EFC44707.1 - 0.21 11.1 2.3 0.74 9.3 0.0 2.7 3 1 0 3 3 3 0 Elongation factor Tu GTP binding domain Prim_Zn_Ribbon PF08273.12 EFC44707.1 - 0.29 11.5 1.3 0.72 10.2 1.3 1.6 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase Roc PF08477.13 EFC44707.1 - 0.29 11.4 2.5 2.4 8.4 0.1 3.6 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase Zn-ribbon_8 PF09723.10 EFC44707.1 - 0.65 10.2 3.8 0.8 9.9 0.3 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Ras PF00071.22 EFC44708.1 - 6.2e-37 126.7 0.1 8e-37 126.3 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44708.1 - 2.7e-17 63.1 0.1 5.2e-17 62.2 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC44708.1 - 4.3e-11 42.7 0.2 7e-11 42.0 0.2 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC44708.1 - 2.1e-09 37.1 0.0 2.8e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ATP_bind_1 PF03029.17 EFC44708.1 - 2.1e-05 24.4 0.3 2.1e-05 24.4 0.3 1.9 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EFC44708.1 - 4.4e-05 23.5 0.0 6.9e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC44708.1 - 4.6e-05 22.9 0.1 6.7e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PGK PF00162.19 EFC44708.1 - 0.072 12.0 0.2 0.6 9.0 0.0 2.0 1 1 1 2 2 2 0 Phosphoglycerate kinase RsgA_GTPase PF03193.16 EFC44708.1 - 0.66 9.9 3.2 14 5.6 0.5 2.8 1 1 1 3 3 3 0 RsgA GTPase DUF3074 PF11274.8 EFC44709.1 - 0.017 15.1 0.1 0.043 13.8 0.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Methyltransf_25 PF13649.6 EFC44710.1 - 1.7e-16 60.7 0.0 4e-16 59.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC44710.1 - 4e-15 56.2 0.0 8.1e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC44710.1 - 8.4e-14 51.5 0.1 1.7e-12 47.2 0.1 2.2 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFC44710.1 - 2.1e-13 50.4 0.1 2.1e-12 47.1 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC44710.1 - 1.5e-10 41.2 0.0 2.2e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC44710.1 - 8.1e-09 36.1 0.0 2.4e-08 34.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 EFC44710.1 - 0.0035 17.2 0.0 0.013 15.3 0.0 2.0 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 EFC44710.1 - 0.074 11.6 0.0 0.19 10.2 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase IclR PF01614.18 EFC44710.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial transcriptional regulator ADH_zinc_N_2 PF13602.6 EFC44711.1 - 3.9e-20 73.2 0.0 5.9e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC44711.1 - 4.6e-20 71.9 0.0 7.3e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC44711.1 - 9.3e-09 35.1 0.0 4.5e-08 32.9 0.0 2.0 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain EF-hand_7 PF13499.6 EFC44712.1 - 7.8e-10 39.1 0.2 1.1e-09 38.6 0.2 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 EFC44712.1 - 1.2e-09 37.0 0.5 0.00016 20.9 0.0 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFC44712.1 - 3.7e-09 35.8 0.3 1.2e-05 24.8 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFC44712.1 - 1.3e-05 24.5 0.6 0.069 12.7 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC44712.1 - 0.0032 17.3 0.2 2.4 8.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair XendoU PF09412.10 EFC44713.1 - 2.1e-66 223.9 0.5 2.4e-66 223.7 0.5 1.0 1 0 0 1 1 1 1 Endoribonuclease XendoU C2 PF00168.30 EFC44714.1 - 1.9e-13 50.5 0.0 4.8e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 C2 domain DUF1292 PF06949.11 EFC44714.1 - 0.15 13.0 0.1 13 6.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1292) DUF4116 PF13475.6 EFC44715.1 - 1.5e-75 248.7 19.2 6.7e-18 64.2 0.1 6.5 2 1 4 7 7 7 6 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC44715.1 - 3.1e-25 89.1 1.6 3.1e-25 89.1 1.6 3.1 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44715.1 - 1e-08 34.8 0.2 4.5e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EFC44715.1 - 0.045 13.4 1.1 7.9 6.0 0.1 2.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFC44715.1 - 0.047 13.0 0.2 0.091 12.1 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Phage_min_cap2 PF06152.11 EFC44716.1 - 0.085 11.7 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Phage minor capsid protein 2 adh_short PF00106.25 EFC44717.1 - 2.4e-35 121.8 0.0 4.1e-35 121.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC44717.1 - 1e-29 103.8 0.0 2.8e-29 102.4 0.0 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase SCP2 PF02036.17 EFC44717.1 - 1e-16 61.3 0.1 1.8e-16 60.4 0.1 1.4 1 0 0 1 1 1 1 SCP-2 sterol transfer family KR PF08659.10 EFC44717.1 - 3.6e-12 46.5 0.1 1.3e-11 44.8 0.0 1.9 2 1 0 2 2 2 1 KR domain Alkyl_sulf_C PF14864.6 EFC44717.1 - 0.0062 16.8 0.1 0.012 15.8 0.1 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal DUF2593 PF10767.9 EFC44717.1 - 0.12 12.4 0.1 0.24 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2593) Ank_3 PF13606.6 EFC44718.1 - 1.1e-07 31.6 0.1 0.00043 20.5 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 EFC44718.1 - 9.1e-07 29.4 0.0 1.7e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC44718.1 - 3.8e-06 27.3 0.1 1e-05 25.9 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC44718.1 - 1e-05 25.7 0.1 0.00031 21.0 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) OprF PF05736.11 EFC44719.1 - 0.012 15.3 0.1 0.52 10.0 0.0 2.3 2 0 0 2 2 2 0 OprF membrane domain LRR_8 PF13855.6 EFC44720.1 - 8.2e-16 57.5 19.1 7.4e-08 32.0 1.3 4.4 2 2 2 4 4 4 4 Leucine rich repeat LRR_6 PF13516.6 EFC44720.1 - 6.8e-14 50.7 15.0 0.00013 21.7 0.1 8.5 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.7 EFC44720.1 - 8.1e-12 45.2 26.7 0.00044 20.6 2.1 6.1 1 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC44720.1 - 3.1e-07 30.1 8.8 0.002 17.7 1.6 2.3 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFC44720.1 - 1.2e-05 25.1 7.7 4.3 8.3 0.1 6.5 7 1 0 7 7 7 3 Leucine Rich Repeat FTH PF01827.27 EFC44720.1 - 0.073 12.9 9.5 0.2 11.5 3.7 2.6 1 1 1 3 3 3 0 FTH domain EI24 PF07264.11 EFC44721.1 - 0.12 12.6 12.1 1.5 9.0 12.1 2.0 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Tetraspanin PF00335.20 EFC44721.1 - 1 9.0 19.9 1.3 8.7 4.5 2.2 2 0 0 2 2 2 0 Tetraspanin family UPF0182 PF03699.13 EFC44721.1 - 1.9 6.5 5.8 0.5 8.4 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0182) FtsX PF02687.21 EFC44721.1 - 1.9 9.0 18.3 1.9 9.0 7.1 3.0 3 0 0 3 3 3 0 FtsX-like permease family DUF898 PF05987.13 EFC44721.1 - 9.6 5.1 12.0 2.2 7.3 3.2 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF898) Saf_2TM PF18303.1 EFC44721.1 - 9.7 5.8 12.0 3.5 7.2 2.2 2.4 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain Guanylate_cyc PF00211.20 EFC44722.1 - 4.8e-06 26.3 0.1 1.3e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain DUF4116 PF13475.6 EFC44723.1 - 1.2e-83 274.7 13.5 1.1e-21 76.3 0.1 6.8 5 1 3 8 8 8 6 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC44723.1 - 1.1e-29 103.6 3.6 1.1e-29 103.6 3.6 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44723.1 - 1.3e-10 41.1 0.5 3.1e-10 39.8 0.5 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4566 PF15130.6 EFC44723.1 - 0.0015 18.0 9.9 5.3 6.4 0.1 5.5 1 1 4 5 5 5 2 Domain of unknown function (DUF4566) NRBF2 PF08961.10 EFC44723.1 - 0.0024 17.5 6.9 0.0046 16.6 6.9 1.3 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator NYD-SP28_assoc PF14775.6 EFC44723.1 - 0.18 11.9 5.8 0.093 12.8 1.7 2.7 1 1 1 2 2 2 0 Sperm tail C-terminal domain Syntaxin-6_N PF09177.11 EFC44723.1 - 1.2 9.7 15.5 0.41 11.2 3.7 3.7 3 1 0 3 3 3 0 Syntaxin 6, N-terminal DUF150_C PF17384.2 EFC44723.1 - 1.7 8.8 6.9 57 4.0 0.1 4.5 2 1 1 4 4 4 0 RimP C-terminal SH3 domain YabA PF06156.13 EFC44723.1 - 8.5 7.1 16.6 0.25 12.0 8.3 2.7 2 1 0 2 2 2 0 Initiation control protein YabA ADP_ribosyl_GH PF03747.14 EFC44724.1 - 6e-39 134.5 0.0 7.2e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase His_Phos_1 PF00300.22 EFC44725.1 - 8.5e-33 113.7 0.0 9.5e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) P53_TAD PF08563.11 EFC44725.1 - 0.097 12.2 0.2 0.16 11.5 0.2 1.3 1 0 0 1 1 1 0 P53 transactivation motif Guanylate_cyc PF00211.20 EFC44726.1 - 3.1e-30 105.2 0.0 6e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain NHL PF01436.21 EFC44727.1 - 0.063 13.3 0.0 78 3.6 0.0 3.7 4 0 0 4 4 4 0 NHL repeat Actin PF00022.19 EFC44728.1 - 1.7e-122 409.0 0.0 7.5e-122 406.9 0.0 1.7 1 1 0 1 1 1 1 Actin Big_9 PF17963.1 EFC44729.1 - 7.6e-133 433.6 222.8 2.2e-17 63.6 4.0 21.0 20 1 1 21 21 21 20 Bacterial Ig domain Cadherin_4 PF17803.1 EFC44729.1 - 2.9e-73 242.4 160.6 1.2e-07 32.3 5.0 20.0 20 0 0 20 20 20 16 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFC44729.1 - 2.5e-41 139.6 134.1 0.00012 22.0 1.1 19.9 15 5 5 20 20 20 15 Cadherin-like domain VWA PF00092.28 EFC44729.1 - 3.4e-17 63.2 3.1 4.8e-15 56.2 0.0 4.5 4 0 0 4 4 4 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC44729.1 - 3.4e-12 46.9 0.7 5.5e-11 43.1 0.1 2.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Cadherin_3 PF16184.5 EFC44729.1 - 0.061 13.3 20.4 2.2 8.3 0.0 9.4 11 0 0 11 11 11 0 Cadherin-like Pkinase PF00069.25 EFC44730.1 - 1.3e-47 162.4 0.3 2.1e-47 161.7 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44730.1 - 1.3e-29 103.2 0.0 2.2e-29 102.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC44730.1 - 8.2e-11 42.1 77.6 0.00051 20.4 11.5 5.8 6 0 0 6 6 5 5 EGF-like domain TMEM154 PF15102.6 EFC44730.1 - 1.7e-07 31.2 0.9 5.8e-07 29.5 0.9 1.9 1 0 0 1 1 1 1 TMEM154 protein family Pkinase_fungal PF17667.1 EFC44730.1 - 1.5e-05 24.0 0.0 2.7e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC44730.1 - 0.00032 19.8 0.1 0.00063 18.8 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain DAG1 PF05454.11 EFC44730.1 - 0.00041 19.8 0.5 0.00087 18.7 0.5 1.4 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) EGF PF00008.27 EFC44730.1 - 0.0018 18.5 56.5 0.021 15.1 3.7 5.8 5 0 0 5 5 5 3 EGF-like domain DUF4064 PF13273.6 EFC44730.1 - 0.04 14.2 0.9 0.19 12.0 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Kdo PF06293.14 EFC44730.1 - 0.065 12.6 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Tcp10_C PF07202.13 EFC44730.1 - 0.088 12.8 0.6 0.26 11.2 0.6 1.8 1 0 0 1 1 1 0 T-complex protein 10 C-terminus SKG6 PF08693.10 EFC44730.1 - 0.56 9.7 9.4 1.4 8.4 9.4 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain RNA_pol_3_Rpc31 PF11705.8 EFC44731.1 - 0.0025 18.1 8.0 0.013 15.7 8.7 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 PUB PF09409.10 EFC44732.1 - 8e-17 60.9 0.7 1.4e-16 60.1 0.7 1.4 1 0 0 1 1 1 1 PUB domain SVIP PF15811.5 EFC44732.1 - 0.0071 16.8 6.0 0.013 15.9 6.0 1.5 1 0 0 1 1 1 1 Small VCP/p97-interacting protein Myb_DNA-binding PF00249.31 EFC44735.1 - 5.3e-07 29.7 0.1 1.1e-06 28.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Abhydrolase_1 PF00561.20 EFC44735.1 - 2.2e-05 24.2 0.1 5.6e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Myb_DNA-bind_7 PF15963.5 EFC44735.1 - 0.0079 16.1 0.1 0.0079 16.1 0.1 2.8 3 0 0 3 3 3 1 Myb DNA-binding like Hydrolase_4 PF12146.8 EFC44735.1 - 0.024 13.9 0.0 0.043 13.1 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC44735.1 - 0.11 13.1 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Orf78 PF06024.12 EFC44735.1 - 1.7 9.0 0.0 1.7 9.0 0.0 4.3 3 1 1 4 4 4 0 Orf78 (ac78) Voldacs PF03517.13 EFC44736.1 - 1.2e-19 70.8 3.6 1.2e-19 70.8 3.6 2.2 2 0 0 2 2 2 1 Regulator of volume decrease after cellular swelling Ribosomal_L18_c PF14204.6 EFC44736.1 - 0.11 13.4 1.8 0.33 11.9 0.9 2.3 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region Acetyltransf_1 PF00583.25 EFC44737.1 - 0.00021 21.5 0.1 0.00036 20.7 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFC44737.1 - 0.047 13.8 0.2 0.15 12.1 0.1 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC44737.1 - 0.063 13.2 0.7 0.13 12.2 0.4 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Terminase_4 PF05119.12 EFC44740.1 - 0.11 13.0 0.2 0.58 10.6 0.0 2.0 2 1 0 2 2 2 0 Phage terminase, small subunit Adap_comp_sub PF00928.21 EFC44741.1 - 9.1e-25 87.5 0.3 1.7e-24 86.6 0.3 1.5 1 0 0 1 1 1 1 Adaptor complexes medium subunit family NEMO PF11577.8 EFC44743.1 - 0.0021 18.0 3.6 0.0042 17.1 3.2 1.7 1 1 0 1 1 1 1 NF-kappa-B essential modulator NEMO HALZ PF02183.18 EFC44743.1 - 0.0048 17.1 2.1 0.0048 17.1 2.1 2.5 2 1 0 2 2 2 1 Homeobox associated leucine zipper DUF4116 PF13475.6 EFC44744.1 - 1.7e-27 94.9 0.0 8e-11 41.5 0.0 3.4 2 1 1 3 3 3 3 Domain of unknown function (DUF4116) HAMP PF00672.25 EFC44745.1 - 0.021 15.2 0.0 0.039 14.3 0.0 1.5 1 0 0 1 1 1 0 HAMP domain BLI1 PF17324.2 EFC44745.1 - 2.6 8.7 6.1 7 7.4 0.2 3.1 2 2 1 3 3 3 0 BLOC-1 interactor 1 Mob_Pre PF01076.19 EFC44746.1 - 0.095 12.5 0.6 0.22 11.3 0.6 1.5 1 0 0 1 1 1 0 Plasmid recombination enzyme TPR_1 PF00515.28 EFC44746.1 - 0.15 12.0 0.7 2.3 8.2 0.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Osw5 PF17062.5 EFC44746.1 - 0.29 11.2 0.1 0.29 11.2 0.1 3.3 3 0 0 3 3 3 0 Outer spore wall 5 Ras PF00071.22 EFC44747.1 - 6.9e-17 61.5 0.0 8.4e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44747.1 - 3.6e-11 43.3 0.1 5.2e-11 42.8 0.1 1.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC44747.1 - 4.7e-08 32.7 0.0 6.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC44747.1 - 0.021 14.2 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region EF-hand_7 PF13499.6 EFC44748.1 - 4.8e-10 39.8 0.1 6.8e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC44748.1 - 9.9e-10 37.6 0.4 0.00091 19.0 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC44748.1 - 1.9e-09 36.4 0.6 0.001 18.5 0.1 2.2 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC44748.1 - 6.9e-06 25.8 0.6 7.4e-05 22.5 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC44748.1 - 0.00016 21.9 0.1 0.00023 21.5 0.1 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 EFC44748.1 - 0.23 11.0 0.1 20 4.9 0.0 2.2 2 0 0 2 2 2 0 EF hand DEAD PF00270.29 EFC44751.1 - 2.8e-45 154.2 0.1 1.4e-44 151.9 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC44751.1 - 2.9e-29 101.7 0.3 5.4e-28 97.6 0.2 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 EFC44751.1 - 0.087 12.1 0.1 0.087 12.1 0.1 2.2 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Macoilin PF09726.9 EFC44751.1 - 8.2 4.8 23.4 12 4.3 23.4 1.2 1 0 0 1 1 1 0 Macoilin family Abhydrolase_1 PF00561.20 EFC44753.1 - 3.3e-06 26.9 0.0 0.00047 19.9 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 EFC44753.1 - 9.1e-06 25.7 0.0 6.9e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 TAP-like protein Hydrolase_4 PF12146.8 EFC44753.1 - 0.0011 18.3 0.0 0.017 14.4 0.0 2.5 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Syndecan PF01034.20 EFC44753.1 - 0.14 12.1 0.7 0.61 10.1 0.1 2.2 2 0 0 2 2 2 0 Syndecan domain AMP-binding PF00501.28 EFC44754.1 - 8.5e-72 242.1 0.0 1.2e-71 241.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme SUKH_6 PF14568.6 EFC44755.1 - 0.25 11.8 4.3 0.61 10.5 4.3 1.8 1 1 0 1 1 1 0 SMI1-KNR4 cell-wall LRR_6 PF13516.6 EFC44757.1 - 1.6e-34 115.0 43.5 1.5e-05 24.7 0.1 12.0 12 1 1 13 13 13 10 Leucine Rich repeat LRR_8 PF13855.6 EFC44757.1 - 1.1e-27 95.6 27.2 5e-09 35.8 0.9 6.0 5 1 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC44757.1 - 2.4e-23 81.8 36.1 6.7e-06 26.3 0.3 8.0 5 2 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC44757.1 - 1.6e-14 52.2 16.6 1.5 9.6 0.0 10.9 11 0 0 11 11 11 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC44757.1 - 4.1e-07 29.7 12.6 0.014 14.9 1.8 3.7 1 1 3 4 4 4 4 Leucine-rich repeat IGR PF09597.10 EFC44757.1 - 0.16 12.1 0.1 3 8.0 0.0 2.9 3 0 0 3 3 3 0 IGR protein motif LVIVD PF08309.11 EFC44757.1 - 0.17 11.2 1.9 18 4.8 0.0 2.7 2 0 0 2 2 2 0 LVIVD repeat Ras PF00071.22 EFC44758.1 - 3.8e-17 62.4 0.0 1.6e-16 60.3 0.0 2.2 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC44758.1 - 9.5e-11 42.0 0.0 3.3e-10 40.2 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC44758.1 - 0.0057 16.7 0.1 0.027 14.6 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC44758.1 - 0.01 15.8 2.7 0.13 12.2 0.2 2.9 2 0 0 2 2 2 0 RsgA GTPase TniB PF05621.11 EFC44758.1 - 0.071 12.5 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein Aminotran_5 PF00266.19 EFC44759.1 - 1.4e-21 76.9 0.0 2.1e-21 76.3 0.0 1.2 1 1 0 1 1 1 1 Aminotransferase class-V ubiquitin PF00240.23 EFC44760.1 - 4.1e-09 36.0 0.0 4.5e-09 35.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC44760.1 - 3.9e-06 26.6 0.0 5.3e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF4116 PF13475.6 EFC44761.1 - 2.1e-86 283.5 14.8 4.6e-15 55.1 0.0 10.6 7 1 4 12 12 12 11 Domain of unknown function (DUF4116) Fe-ADH_2 PF13685.6 EFC44761.1 - 0.15 11.7 0.0 0.37 10.4 0.0 1.6 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase ThiF PF00899.21 EFC44762.1 - 5e-21 75.2 0.0 1.1e-20 74.0 0.0 1.6 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 EFC44762.1 - 5.4e-06 26.5 0.3 0.024 14.8 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin-activating enzyme E1 four-helix bundle S10_plectin PF03501.15 EFC44763.1 - 3.3e-38 129.7 0.1 4.4e-38 129.2 0.1 1.2 1 0 0 1 1 1 1 Plectin/S10 domain 5_3_exonuc_N PF02739.16 EFC44763.1 - 0.029 14.3 0.1 0.042 13.8 0.1 1.1 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain WI12 PF07107.11 EFC44763.1 - 0.086 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Wound-induced protein WI12 F-box PF00646.33 EFC44764.1 - 0.00055 19.7 1.0 0.0012 18.7 1.0 1.6 1 0 0 1 1 1 1 F-box domain Ras PF00071.22 EFC44764.1 - 0.0047 16.5 0.1 0.092 12.3 0.0 2.2 2 0 0 2 2 2 1 Ras family DUF5432 PF17497.2 EFC44764.1 - 0.091 12.9 1.4 0.32 11.1 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5432) MFS_1 PF07690.16 EFC44765.1 - 2.8e-24 85.7 55.7 7.3e-21 74.5 24.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 EFC44765.1 - 4.9e-13 49.1 7.3 4.9e-13 49.1 7.3 2.1 2 1 0 2 2 2 1 Nodulin-like TssO PF17561.2 EFC44765.1 - 0.87 9.7 0.0 0.87 9.7 0.0 3.5 4 0 0 4 4 4 0 Type VI secretion system, TssO Ras PF00071.22 EFC44766.1 - 1.4e-27 96.2 0.0 1.9e-27 95.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC44766.1 - 1.5e-12 47.8 0.0 6.9e-12 45.6 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC44766.1 - 0.0015 18.0 0.0 0.0034 16.8 0.0 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EFC44766.1 - 0.008 15.7 0.0 0.0096 15.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EFC44766.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EFC44766.1 - 0.14 12.5 0.1 2.7 8.3 0.1 2.4 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFC44767.1 - 1e-43 149.2 1.8 9.4e-20 71.5 0.0 3.6 3 0 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 EFC44767.1 - 2.9e-19 70.0 13.1 3.6e-05 23.7 0.1 5.0 3 2 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC44767.1 - 1.4e-08 34.5 3.8 0.0071 15.8 0.0 4.2 3 1 2 5 5 5 3 RecF/RecN/SMC N terminal domain NACHT PF05729.12 EFC44767.1 - 8e-08 32.4 0.0 0.0023 17.9 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_29 PF13555.6 EFC44767.1 - 1.1e-07 31.4 0.5 0.015 15.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC44767.1 - 2.8e-07 31.1 0.0 0.035 14.5 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 EFC44767.1 - 4.3e-06 26.7 13.1 0.00057 19.7 9.9 2.8 1 1 1 2 2 2 2 AAA ATPase domain DUF3584 PF12128.8 EFC44767.1 - 4.1e-05 21.4 9.2 0.024 12.2 0.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF3584) TsaE PF02367.17 EFC44767.1 - 0.00015 21.8 0.1 0.82 9.7 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 EFC44767.1 - 0.00016 22.1 0.0 0.58 10.6 0.0 3.5 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC44767.1 - 0.00017 21.9 1.4 1.5 9.1 0.4 3.5 2 2 0 2 2 2 2 AAA domain Roc PF08477.13 EFC44767.1 - 0.00021 21.5 0.4 0.06 13.6 0.2 3.3 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 EFC44767.1 - 0.00022 20.4 0.1 0.087 11.9 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 EFC44767.1 - 0.0004 20.2 1.4 0.14 11.8 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_18 PF13238.6 EFC44767.1 - 0.00044 20.8 1.3 1.8 9.1 0.0 3.5 3 1 1 4 4 3 2 AAA domain NTPase_1 PF03266.15 EFC44767.1 - 0.00052 20.0 0.4 0.77 9.7 0.0 3.1 3 0 0 3 3 2 1 NTPase AAA_23 PF13476.6 EFC44767.1 - 0.00062 20.3 25.1 0.034 14.6 0.1 3.6 1 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFC44767.1 - 0.0011 19.0 0.1 1.6 8.6 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_5 PF07728.14 EFC44767.1 - 0.0013 18.7 0.3 1.9 8.5 0.0 3.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) DEAD PF00270.29 EFC44767.1 - 0.0015 18.4 0.2 0.18 11.5 0.0 3.1 2 2 0 2 2 2 1 DEAD/DEAH box helicase PduV-EutP PF10662.9 EFC44767.1 - 0.0017 18.1 0.0 1.5 8.6 0.0 3.3 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EFC44767.1 - 0.0019 18.4 0.0 2.6 8.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFC44767.1 - 0.0019 17.8 0.2 0.51 9.9 0.0 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Mt_ATP-synt_D PF05873.12 EFC44767.1 - 0.003 17.4 3.9 0.056 13.3 0.0 3.1 2 1 1 3 3 3 1 ATP synthase D chain, mitochondrial (ATP5H) ATP-synt_ab PF00006.25 EFC44767.1 - 0.0035 17.0 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ABC_tran_Xtn PF12848.7 EFC44767.1 - 0.0037 17.2 9.2 0.0064 16.5 8.4 1.7 1 1 0 1 1 1 1 ABC transporter AAA_24 PF13479.6 EFC44767.1 - 0.0043 16.8 3.9 0.49 10.1 0.1 3.1 3 1 0 4 4 3 1 AAA domain AAA_28 PF13521.6 EFC44767.1 - 0.0055 17.0 0.1 6.7 6.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 EFC44767.1 - 0.0071 15.8 0.0 0.27 10.6 0.0 2.9 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EFC44767.1 - 0.0091 16.4 0.0 4.8 7.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase AAA_14 PF13173.6 EFC44767.1 - 0.0095 16.0 0.5 0.71 9.9 0.0 3.4 3 1 0 3 3 2 1 AAA domain DLIC PF05783.11 EFC44767.1 - 0.012 14.5 0.0 0.95 8.2 0.0 2.3 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) FtsK_SpoIIIE PF01580.18 EFC44767.1 - 0.016 14.6 0.1 1.5 8.1 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EFC44767.1 - 0.018 14.6 0.1 6.5 6.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EFC44767.1 - 0.021 14.9 0.1 5 7.2 0.1 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_25 PF13481.6 EFC44767.1 - 0.025 14.2 0.2 24 4.4 0.1 3.2 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 EFC44767.1 - 0.028 14.8 0.1 2.5 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain GvpD PF07088.11 EFC44767.1 - 0.028 13.0 0.1 0.53 8.8 0.0 2.1 2 0 0 2 2 2 0 GvpD gas vesicle protein AAA_27 PF13514.6 EFC44767.1 - 0.035 13.7 5.2 0.44 10.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain NB-ARC PF00931.22 EFC44767.1 - 0.036 13.2 4.6 1.7 7.8 0.3 3.5 4 1 0 4 4 3 0 NB-ARC domain SRPRB PF09439.10 EFC44767.1 - 0.043 13.3 2.6 3.2 7.2 0.0 2.9 3 0 0 3 3 2 0 Signal recognition particle receptor beta subunit SbcCD_C PF13558.6 EFC44767.1 - 0.057 13.7 0.0 7 7.0 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RuvB_N PF05496.12 EFC44767.1 - 0.077 12.7 0.0 2.6 7.8 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Zeta_toxin PF06414.12 EFC44767.1 - 0.095 12.0 2.5 4.2 6.6 0.0 3.2 3 1 0 3 3 3 0 Zeta toxin SRP54 PF00448.22 EFC44767.1 - 0.099 12.3 0.1 14 5.2 0.1 2.4 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MobB PF03205.14 EFC44767.1 - 0.1 12.5 0.5 6.8 6.6 0.1 2.6 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_11 PF13086.6 EFC44767.1 - 0.1 12.4 13.1 4 7.2 0.0 2.8 1 1 1 2 2 2 0 AAA domain Pox_A32 PF04665.12 EFC44767.1 - 0.18 11.3 0.0 0.18 11.3 0.0 3.4 4 0 0 4 4 3 0 Poxvirus A32 protein ATP_bind_1 PF03029.17 EFC44767.1 - 0.43 10.3 6.6 6.2 6.5 0.1 3.2 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein Fzo_mitofusin PF04799.13 EFC44767.1 - 0.48 10.0 4.8 0.62 9.6 1.3 2.2 2 0 0 2 2 2 0 fzo-like conserved region APG17 PF04108.12 EFC44768.1 - 2.4e-08 33.5 30.5 1.3e-05 24.6 9.3 3.5 2 1 1 3 3 3 2 Autophagy protein Apg17 THDPS_N PF14790.6 EFC44768.1 - 0.018 14.9 1.4 0.018 14.9 1.4 3.2 3 1 2 5 5 5 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Cnn_1N PF07989.11 EFC44768.1 - 0.023 14.8 4.4 0.027 14.6 1.5 2.8 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 ZapB PF06005.12 EFC44768.1 - 2.3 8.7 10.9 0.49 10.9 4.6 3.2 2 0 0 2 2 2 0 Cell division protein ZapB TPR_2 PF07719.17 EFC44769.1 - 2.3e-05 24.2 6.5 0.14 12.3 0.3 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44769.1 - 0.00058 20.1 1.1 3.4 8.0 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC44769.1 - 0.0035 17.6 8.0 4.2 8.0 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC44769.1 - 0.0071 16.3 0.1 2.5 8.3 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44769.1 - 0.013 15.6 5.7 2.8 8.4 0.7 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC44769.1 - 0.016 16.0 0.0 2.3 9.3 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44769.1 - 0.017 14.9 9.5 0.23 11.3 0.7 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC44769.1 - 0.11 12.2 2.3 0.48 10.1 0.1 2.8 3 0 0 3 3 3 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 EFC44769.1 - 0.12 12.7 9.5 2 8.7 0.0 3.6 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Mut7-C PF01927.16 EFC44770.1 - 3e-27 95.5 6.0 5.9e-25 88.1 4.6 2.5 2 1 0 2 2 2 1 Mut7-C RNAse domain APG17 PF04108.12 EFC44770.1 - 0.0013 17.9 2.1 0.0024 17.1 2.1 1.4 1 0 0 1 1 1 1 Autophagy protein Apg17 FapA PF03961.13 EFC44770.1 - 0.0059 15.3 4.0 0.0088 14.7 4.0 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A CdiI_2 PF18593.1 EFC44770.1 - 0.0081 16.8 3.7 2.5 8.8 0.5 2.8 2 0 0 2 2 2 2 CdiI immunity protein FliJ PF02050.16 EFC44770.1 - 0.017 15.3 3.0 0.32 11.2 1.8 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein Chlor_dismutase PF06778.12 EFC44770.1 - 0.026 14.1 0.6 0.041 13.4 0.6 1.2 1 0 0 1 1 1 0 Chlorite dismutase TMPIT PF07851.13 EFC44770.1 - 0.06 12.6 2.9 0.11 11.8 2.9 1.4 1 0 0 1 1 1 0 TMPIT-like protein PspA_IM30 PF04012.12 EFC44770.1 - 0.18 11.4 4.5 0.33 10.5 4.5 1.3 1 0 0 1 1 1 0 PspA/IM30 family AAA_23 PF13476.6 EFC44770.1 - 0.84 10.1 10.1 0.34 11.4 6.4 2.0 2 0 0 2 2 2 0 AAA domain ZapB PF06005.12 EFC44770.1 - 2.4 8.6 10.6 2.1 8.9 8.2 2.1 2 0 0 2 2 2 0 Cell division protein ZapB zf-C2H2_9 PF16293.5 EFC44770.1 - 2.6 7.9 5.2 1.2 9.0 0.4 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Fib_alpha PF08702.10 EFC44770.1 - 7.4 6.7 12.1 17 5.6 8.1 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Ank_2 PF12796.7 EFC44771.1 - 0.0095 16.5 0.0 0.042 14.4 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC44771.1 - 0.031 14.6 0.0 0.12 12.7 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DUF2773 PF10971.8 EFC44771.1 - 0.044 13.9 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2773) ArsC PF03960.15 EFC44771.1 - 0.11 12.5 0.1 0.45 10.6 0.0 2.0 2 0 0 2 2 2 0 ArsC family DEAD PF00270.29 EFC44772.1 - 2.9e-52 177.0 0.0 6.2e-51 172.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC44772.1 - 7.7e-35 119.6 0.1 8.7e-34 116.2 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC44772.1 - 1.3e-08 35.0 0.0 1.7e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 EFC44772.1 - 0.00065 18.5 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain GRP PF07172.11 EFC44772.1 - 0.03 15.0 10.6 0.03 15.0 10.6 2.8 3 0 0 3 3 3 0 Glycine rich protein family UTP25 PF06862.12 EFC44772.1 - 0.033 13.0 0.1 0.29 9.9 0.0 2.0 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 EFC44772.1 - 0.078 12.3 0.2 0.21 10.9 0.0 1.7 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit tRNA-synt_1b PF00579.25 EFC44772.1 - 0.092 12.1 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Hydrolase_4 PF12146.8 EFC44773.1 - 9.6e-21 74.1 0.0 1.8e-20 73.2 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC44773.1 - 6.8e-15 55.4 0.1 1.2e-13 51.3 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC44773.1 - 7.6e-10 39.8 0.0 1e-09 39.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 EFC44773.1 - 7.3e-06 25.8 0.0 0.032 14.0 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family LIDHydrolase PF10230.9 EFC44773.1 - 5.9e-05 22.8 0.7 0.00025 20.7 0.1 1.9 1 1 1 2 2 2 1 Lipid-droplet associated hydrolase Abhydrolase_4 PF08386.10 EFC44773.1 - 0.00033 20.7 0.0 0.00093 19.3 0.0 1.7 2 0 0 2 2 2 1 TAP-like protein FSH1 PF03959.13 EFC44773.1 - 0.055 13.1 0.1 0.12 12.0 0.0 1.8 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Ndr PF03096.14 EFC44773.1 - 0.065 11.9 0.1 0.35 9.5 0.1 2.0 1 1 0 1 1 1 0 Ndr family RhoGEF PF00621.20 EFC44775.1 - 5.3e-45 153.9 5.1 5.3e-45 153.9 5.1 2.3 2 0 0 2 2 2 1 RhoGEF domain SH3_1 PF00018.28 EFC44775.1 - 7.5e-12 44.7 0.1 1.4e-11 43.8 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFC44775.1 - 1.1e-09 38.0 0.0 2.1e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFC44775.1 - 5.9e-07 29.1 0.0 1.3e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain RRM_7 PF16367.5 EFC44775.1 - 0.014 15.5 0.1 0.079 13.1 0.1 2.3 1 0 0 1 1 1 0 RNA recognition motif Trp_repressor PF01371.19 EFC44775.1 - 0.12 12.5 1.9 0.23 11.6 0.2 2.4 2 0 0 2 2 2 0 Trp repressor protein Tweety PF04906.13 EFC44775.1 - 0.13 10.9 0.5 0.25 10.0 0.5 1.4 1 0 0 1 1 1 0 Tweety Thioredoxin PF00085.20 EFC44776.1 - 1.2e-06 28.5 0.2 2e-06 27.7 0.2 1.4 1 0 0 1 1 1 1 Thioredoxin DUF3336 PF11815.8 EFC44776.1 - 0.0089 15.7 0.5 0.015 15.0 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Snf7 PF03357.21 EFC44777.1 - 1.1e-37 129.3 27.7 1.1e-37 129.3 27.7 1.3 1 1 0 1 1 1 1 Snf7 Prefoldin PF02996.17 EFC44777.1 - 0.005 16.8 3.1 0.005 16.8 3.1 3.3 1 1 2 3 3 3 1 Prefoldin subunit Mito_fiss_reg PF05308.11 EFC44777.1 - 0.013 15.6 3.1 0.019 15.1 3.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator FliJ PF02050.16 EFC44777.1 - 0.031 14.5 12.9 0.031 14.5 12.9 2.4 3 1 0 3 3 2 0 Flagellar FliJ protein Rpn3_C PF08375.11 EFC44777.1 - 0.04 14.3 0.9 0.04 14.3 0.9 3.0 3 1 0 3 3 3 0 Proteasome regulatory subunit C-terminal Actin PF00022.19 EFC44777.1 - 0.12 10.9 3.9 0.15 10.6 3.9 1.1 1 0 0 1 1 1 0 Actin RNA_pol_L PF01193.24 EFC44777.1 - 0.18 11.2 0.5 0.35 10.3 0.5 1.6 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF1319 PF07028.11 EFC44777.1 - 0.36 11.1 10.9 0.22 11.8 6.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) DUF2802 PF10975.8 EFC44777.1 - 1.9 8.7 10.4 1 9.5 3.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2802) Striatin PF08232.12 EFC44777.1 - 2.1 8.9 14.9 7 7.2 12.5 2.2 1 1 1 2 2 2 0 Striatin family RB_A PF01858.17 EFC44777.1 - 2.1 8.1 8.8 20 4.9 6.7 2.2 1 1 1 2 2 2 0 Retinoblastoma-associated protein A domain Syntaxin_2 PF14523.6 EFC44777.1 - 3 8.3 16.0 3.9 7.9 7.5 2.4 1 1 1 2 2 2 0 Syntaxin-like protein Bcr-Abl_Oligo PF09036.10 EFC44777.1 - 3.2 7.8 8.2 2.2 8.3 5.0 2.2 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain DUF4140 PF13600.6 EFC44777.1 - 3.3 8.2 8.4 4 8.0 1.7 2.8 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.12 EFC44777.1 - 3.4 7.7 15.8 4.2 7.4 9.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 EFC44777.1 - 4.2 7.7 12.2 1.2e+03 -0.2 12.2 3.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF5320 PF17253.2 EFC44777.1 - 4.2 8.5 9.7 2 9.5 0.3 3.4 2 1 1 3 3 3 0 Family of unknown function (DUF5320) DUF2312 PF10073.9 EFC44777.1 - 4.3 7.1 13.4 1.7 8.3 4.7 2.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF883 PF05957.13 EFC44777.1 - 4.6 7.9 8.4 12 6.6 3.9 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) PRKG1_interact PF15898.5 EFC44777.1 - 4.6 8.2 16.0 3.5 8.6 3.0 2.8 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain V_ATPase_I PF01496.19 EFC44777.1 - 5.7 4.7 13.9 8.6 4.1 13.7 1.3 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family ABC_tran_CTD PF16326.5 EFC44777.1 - 5.8 7.3 20.3 11 6.3 9.8 3.4 3 1 0 3 3 3 0 ABC transporter C-terminal domain DUF2203 PF09969.9 EFC44777.1 - 5.9 7.6 10.3 7.3 7.3 0.5 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Rho_Binding PF08912.11 EFC44777.1 - 8 7.4 19.2 2 9.3 9.0 3.4 3 1 0 3 3 2 0 Rho Binding CorA PF01544.18 EFC44777.1 - 8.5 5.6 10.4 30 3.8 10.4 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein Atg14 PF10186.9 EFC44777.1 - 9 5.3 13.1 11 5.0 4.3 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 IQ PF00612.27 EFC44778.1 - 5.5e-07 28.8 22.7 0.0012 18.5 0.4 4.6 5 0 0 5 5 5 3 IQ calmodulin-binding motif DUF4266 PF14086.6 EFC44778.1 - 4.2 8.4 5.7 8.2 7.5 2.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4266) DUF5102 PF17104.5 EFC44779.1 - 0.0001 22.5 2.0 0.0001 22.5 2.0 14.6 6 4 8 14 14 14 5 Domain of unknown function (DUF5102) DUF459 PF04311.13 EFC44779.1 - 0.1 11.6 0.4 9.7 5.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF459) EGF_2 PF07974.13 EFC44780.1 - 1.7e-136 444.1 712.8 5.4e-06 26.7 6.9 46.6 46 0 0 46 46 46 44 EGF-like domain EGF PF00008.27 EFC44780.1 - 1.1e-18 67.2 550.6 0.0013 19.0 3.9 46.1 45 0 0 45 45 45 34 EGF-like domain GATA PF00320.27 EFC44781.1 - 2.6e-09 36.5 3.6 2.6e-09 36.5 3.6 3.0 4 0 0 4 4 4 1 GATA zinc finger PHD PF00628.29 EFC44781.1 - 0.0012 18.7 9.4 0.0039 17.1 9.4 1.9 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 EFC44781.1 - 7.4 6.7 10.1 33 4.7 10.1 2.2 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 EFC44781.1 - 9.7 6.2 17.5 0.84 9.6 10.3 2.7 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FH2 PF02181.23 EFC44783.1 - 6.4e-53 180.2 21.0 6.4e-53 180.2 21.0 2.6 2 1 1 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFC44783.1 - 1.1e-10 41.5 4.7 1.1e-10 41.4 1.1 2.8 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 EFC44783.1 - 1e-09 38.3 4.7 1e-09 38.3 4.7 3.5 2 1 0 2 2 2 1 Diaphanous FH3 Domain Drf_FH1 PF06346.12 EFC44783.1 - 0.014 15.1 57.5 0.021 14.5 57.5 1.2 1 0 0 1 1 1 0 Formin Homology Region 1 GreA_GreB_N PF03449.15 EFC44783.1 - 0.15 12.2 3.9 5.2 7.3 0.1 3.4 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Cor1 PF04803.12 EFC44783.1 - 7.7 6.7 25.0 0.12 12.6 15.8 3.0 3 0 0 3 3 3 0 Cor1/Xlr/Xmr conserved region YqgF PF14639.6 EFC44783.1 - 8.6 6.1 8.9 14 5.4 1.2 3.1 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 Sortilin-Vps10 PF15902.5 EFC44785.1 - 1.6e-73 248.0 4.0 2.8e-73 247.2 4.0 1.4 1 1 0 1 1 1 1 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 EFC44785.1 - 2.5e-34 119.1 8.1 6.1e-34 117.8 8.1 1.6 1 0 0 1 1 1 1 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 EFC44785.1 - 0.068 13.2 0.6 2.3 8.6 0.1 3.4 3 0 0 3 3 3 0 BNR/Asp-box repeat ABC_export PF16962.5 EFC44786.1 - 0.015 13.8 0.6 0.023 13.2 0.6 1.2 1 0 0 1 1 1 0 Putative ABC exporter DUF3800 PF12686.7 EFC44786.1 - 0.12 13.0 7.1 26 5.5 0.2 3.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3800) AvrPto PF11592.8 EFC44786.1 - 0.15 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Central core of the bacterial effector protein AvrPto LPP PF04728.13 EFC44786.1 - 0.53 10.7 6.7 7.9 7.0 0.7 4.1 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF1818 PF08848.11 EFC44786.1 - 3.1 7.9 15.4 0.28 11.3 4.2 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF1818) DUF2353 PF09789.9 EFC44786.1 - 3.7 6.8 53.9 20 4.4 36.4 3.7 2 1 1 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) DUF3450 PF11932.8 EFC44786.1 - 5.6 6.2 40.0 1.6 8.0 5.5 4.3 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) Phage_Gp23 PF10669.9 EFC44788.1 - 0.0066 16.8 2.0 0.0087 16.4 2.0 1.3 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) FliJ PF02050.16 EFC44788.1 - 0.02 15.1 6.6 0.052 13.8 6.6 1.6 1 1 0 1 1 1 0 Flagellar FliJ protein MHC_II_beta PF00969.19 EFC44788.1 - 0.04 14.0 2.7 1.3 9.2 0.1 2.8 1 1 1 2 2 2 0 Class II histocompatibility antigen, beta domain Med9 PF07544.13 EFC44788.1 - 0.041 14.0 7.0 0.53 10.4 7.0 2.1 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Atg14 PF10186.9 EFC44788.1 - 0.078 12.0 2.6 0.095 11.8 2.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Herpes_UL14 PF03580.14 EFC44788.1 - 0.092 13.0 2.3 0.13 12.5 2.3 1.2 1 0 0 1 1 1 0 Herpesvirus UL14-like protein DUF16 PF01519.16 EFC44788.1 - 0.28 11.7 7.8 0.52 10.8 7.8 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1664 PF07889.12 EFC44788.1 - 1.4 9.0 7.4 5.4 7.1 0.9 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 EFC44788.1 - 2.1 8.5 6.6 0.85 9.8 1.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Halogen_Hydrol PF10112.9 EFC44788.1 - 5.7 6.9 10.0 0.06 13.4 0.9 2.0 2 1 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Pkinase PF00069.25 EFC44789.1 - 3.2e-21 75.9 4.9 1.1e-20 74.2 4.9 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44789.1 - 3.3e-14 52.8 2.4 7.6e-14 51.6 2.4 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC44789.1 - 5.7e-06 26.6 26.5 0.00078 19.8 8.5 2.8 2 0 0 2 2 2 2 EGF-like domain DUF872 PF05915.12 EFC44789.1 - 0.027 14.7 0.0 0.12 12.6 0.0 2.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) EGF_Tenascin PF18720.1 EFC44789.1 - 0.59 10.2 14.2 0.024 14.7 2.0 2.8 2 0 0 2 2 2 0 Tenascin EGF domain V-ATPase_G PF03179.15 EFC44790.1 - 6.6e-23 81.2 17.4 9.9e-23 80.7 17.4 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit APG6_N PF17675.1 EFC44790.1 - 0.0018 18.8 14.1 0.0018 18.8 14.1 1.7 2 0 0 2 2 2 1 Apg6 coiled-coil region Ldh_1_N PF00056.23 EFC44790.1 - 0.013 15.5 0.4 0.024 14.7 0.4 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Complex1_49kDa PF00346.19 EFC44790.1 - 0.72 8.9 4.7 1.1 8.3 0.1 2.0 1 1 1 2 2 2 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Spc7 PF08317.11 EFC44790.1 - 1 8.2 16.7 1.2 7.9 16.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein ATP-synt_B PF00430.18 EFC44790.1 - 1.2 9.2 18.0 0.12 12.5 12.4 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF3552 PF12072.8 EFC44790.1 - 1.3 8.4 20.5 2.4 7.5 20.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) YlqD PF11068.8 EFC44790.1 - 6.3 7.2 21.0 1.7 9.0 15.7 1.9 1 1 1 2 2 2 0 YlqD protein LETM1 PF07766.13 EFC44791.1 - 1.5e-13 50.7 5.3 5.4e-12 45.6 5.3 2.2 1 1 0 1 1 1 1 LETM1-like protein CBS PF00571.28 EFC44792.1 - 1.2e-23 83.2 0.1 6.3e-06 26.5 0.1 4.2 4 0 0 4 4 4 4 CBS domain IQ PF00612.27 EFC44793.1 - 2.5e-08 33.0 4.7 0.0053 16.4 1.9 3.0 2 0 0 2 2 2 2 IQ calmodulin-binding motif TPR_12 PF13424.6 EFC44793.1 - 0.025 14.8 0.2 0.061 13.6 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC44793.1 - 0.24 11.6 5.3 0.49 10.6 2.3 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 EFC44793.1 - 0.26 11.5 1.4 2 8.7 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Symplekin_C PF12295.8 EFC44794.1 - 0.00011 22.4 1.8 0.00039 20.6 0.9 2.5 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal Glyco_transf_25 PF01755.17 EFC44795.1 - 1e-20 74.4 0.1 6e-19 68.7 0.1 2.9 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Tetraspanin PF00335.20 EFC44795.1 - 0.083 12.6 2.4 0.69 9.6 0.1 2.4 2 0 0 2 2 2 0 Tetraspanin family TRP PF06011.12 EFC44795.1 - 1.4 7.5 9.4 0.035 12.8 0.6 2.4 3 1 0 3 3 3 0 Transient receptor potential (TRP) ion channel DUF4131 PF13567.6 EFC44795.1 - 4.3 7.0 4.6 28 4.3 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) adh_short_C2 PF13561.6 EFC44796.1 - 1.7e-54 184.9 0.0 2.1e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC44796.1 - 4.9e-41 140.3 0.0 6.5e-41 139.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC44796.1 - 2.5e-08 34.0 0.0 3.3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFC44796.1 - 0.00082 18.8 0.1 0.0011 18.4 0.1 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Peripla_BP_2 PF01497.18 EFC44796.1 - 0.086 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein Polysacc_synt_2 PF02719.15 EFC44796.1 - 0.11 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Bactofilin PF04519.13 EFC44797.1 - 2.1e-08 34.4 14.1 0.011 16.1 0.2 6.0 4 1 1 5 5 5 4 Polymer-forming cytoskeletal ADH_N PF08240.12 EFC44798.1 - 3.8e-29 100.8 1.1 1.3e-28 99.0 1.5 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC44798.1 - 3.6e-07 30.2 0.2 0.21 11.6 0.0 3.7 4 0 0 4 4 4 2 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 EFC44798.1 - 0.0029 17.5 0.1 0.0067 16.3 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated HI0933_like PF03486.14 EFC44798.1 - 0.0032 16.3 0.0 0.0047 15.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein AlaDh_PNT_C PF01262.21 EFC44798.1 - 0.026 13.8 0.0 0.062 12.6 0.0 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 EFC44798.1 - 0.032 13.5 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 EFC44798.1 - 0.053 13.1 0.0 0.15 11.6 0.0 1.8 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glu_dehyd_C PF16912.5 EFC44798.1 - 0.075 12.5 0.1 2.9 7.3 0.0 2.6 3 0 0 3 3 3 0 Glucose dehydrogenase C-terminus LRR_9 PF14580.6 EFC44799.1 - 7.6e-13 48.3 1.0 1.2e-12 47.7 1.0 1.3 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC44799.1 - 5.9e-10 39.2 18.5 2e-05 24.9 1.1 3.5 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC44799.1 - 6.7e-06 25.8 14.0 0.00014 21.5 4.7 3.2 2 1 1 3 3 3 2 Leucine rich repeat PDZ_3 PF17815.1 EFC44799.1 - 0.0086 15.9 0.0 0.013 15.4 0.0 1.3 1 1 0 1 1 1 1 PDZ domain LRR_1 PF00560.33 EFC44799.1 - 5.4 8.0 8.4 9.2 7.3 1.2 3.3 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC44799.1 - 7.5 6.9 13.1 2 8.7 0.6 3.8 4 1 0 4 4 4 0 Leucine Rich repeat DUF4116 PF13475.6 EFC44800.1 - 1.2e-64 213.8 2.1 5.8e-14 51.5 0.0 7.0 1 1 8 9 9 9 8 Domain of unknown function (DUF4116) CAMSAP_CKK PF08683.11 EFC44800.1 - 0.11 12.7 0.1 1.1 9.5 0.0 2.5 2 1 1 3 3 3 0 Microtubule-binding calmodulin-regulated spectrin-associated CDP-OH_P_transf PF01066.21 EFC44801.1 - 1.6e-16 60.8 1.1 1.9e-16 60.5 0.3 1.6 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Zn_clus PF00172.18 EFC44802.1 - 1.5e-09 37.8 9.1 1.5e-09 37.8 9.1 1.9 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MBOAT PF03062.19 EFC44804.1 - 7.8e-22 78.1 16.5 7.8e-22 78.1 16.5 3.1 3 0 0 3 3 3 2 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 EFC44804.1 - 0.00074 19.7 3.8 0.00074 19.7 3.8 2.6 2 1 0 2 2 2 1 Membrane bound O-acyl transferase family DUF1003 PF06210.11 EFC44804.1 - 0.44 10.7 0.0 0.44 10.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) COX14 PF14880.6 EFC44804.1 - 3.1 7.7 4.9 3.6 7.5 0.8 2.5 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Ntox14 PF15522.6 EFC44806.1 - 0.081 12.3 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Novel toxin 14 DUF5305 PF17231.2 EFC44806.1 - 0.3 10.5 0.0 0.3 10.5 0.0 3.6 4 0 0 4 4 4 0 Family of unknown function (DUF5305) Trypsin_2 PF13365.6 EFC44807.1 - 0.019 15.9 0.0 0.03 15.2 0.0 1.4 1 0 0 1 1 1 0 Trypsin-like peptidase domain Pkinase PF00069.25 EFC44808.1 - 2.1e-72 243.7 0.0 2.5e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44808.1 - 4.9e-44 150.6 0.0 6.1e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC44808.1 - 9.8e-06 25.1 0.0 8.5e-05 22.0 0.0 2.0 1 1 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EFC44808.1 - 0.0038 16.8 0.2 0.0076 15.8 0.2 1.5 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EFC44808.1 - 0.005 15.7 0.0 0.0061 15.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC44808.1 - 0.0056 16.6 3.4 0.17 11.8 0.4 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC44808.1 - 0.012 14.7 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 EFC44808.1 - 0.048 12.6 0.1 0.072 12.0 0.1 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Presenilin PF01080.17 EFC44809.1 - 1.4 7.6 11.5 1.8 7.2 11.5 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFC44809.1 - 1.9 7.6 5.5 3.3 6.8 5.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 EFC44809.1 - 2 8.1 9.1 3.2 7.5 9.1 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Tti2 PF10521.9 EFC44809.1 - 3.6 7.1 8.2 36 3.8 0.0 2.3 2 0 0 2 2 2 0 Tti2 family Lactamase_B_2 PF12706.7 EFC44810.1 - 1.6e-11 44.1 0.0 5e-05 22.9 0.0 2.6 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFC44810.1 - 7.1e-05 22.9 0.4 0.00024 21.2 0.2 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily DUF4457 PF14652.6 EFC44811.1 - 2.4e-182 605.5 14.6 1.7e-132 441.6 0.2 5.3 4 1 1 5 5 5 4 Domain of unknown function (DUF4457) Sad1_UNC PF07738.13 EFC44811.1 - 0.00011 22.3 0.1 5.5 7.0 0.0 5.5 7 0 0 7 7 7 2 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 EFC44811.1 - 0.00052 20.1 2.7 0.69 10.0 0.0 4.5 5 0 0 5 5 5 1 F5/8 type C domain WD40 PF00400.32 EFC44812.1 - 1.7e-32 110.9 26.4 8.1e-05 23.3 0.1 10.0 11 0 0 11 11 11 7 WD domain, G-beta repeat Utp13 PF08625.11 EFC44812.1 - 3.1e-27 95.2 1.8 6.2e-27 94.2 1.8 1.6 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 EFC44812.1 - 2.2e-25 88.8 2.7 8.9e-06 25.9 0.0 7.9 3 2 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC44812.1 - 1.2e-06 27.8 7.3 0.26 10.2 0.1 5.6 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 EFC44812.1 - 1.7e-06 28.0 2.1 0.9 9.6 0.0 5.1 4 1 1 5 5 5 3 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 EFC44812.1 - 0.00027 20.4 0.2 0.00027 20.4 0.2 4.5 5 1 0 5 5 5 1 WD40-like domain Cytochrom_D1 PF02239.16 EFC44812.1 - 0.0004 19.0 0.1 0.0058 15.2 0.0 2.5 3 0 0 3 3 3 1 Cytochrome D1 heme domain HPS3_N PF14761.6 EFC44812.1 - 0.0085 15.6 0.1 0.57 9.7 0.0 3.0 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3 Rhamno_transf PF11316.8 EFC44812.1 - 0.028 13.8 0.1 0.076 12.4 0.0 1.7 2 0 0 2 2 2 0 Putative rhamnosyl transferase Isy1 PF06246.12 EFC44814.1 - 1.6e-75 254.0 14.5 1.8e-75 253.8 14.5 1.0 1 0 0 1 1 1 1 Isy1-like splicing family ECH_1 PF00378.20 EFC44815.1 - 6.5e-49 166.5 0.1 7.9e-49 166.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC44815.1 - 1.7e-13 50.8 0.0 2.3e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Endonuc_Holl PF10107.9 EFC44815.1 - 0.034 14.0 0.4 0.056 13.3 0.4 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase DUF1033 PF06279.11 EFC44815.1 - 0.086 13.0 0.4 10 6.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1033) SRP68 PF16969.5 EFC44816.1 - 4.1e-91 306.7 40.2 2.4e-88 297.5 16.7 2.7 1 1 0 2 2 2 2 RNA-binding signal recognition particle 68 FERM_M PF00373.18 EFC44816.1 - 0.11 13.0 10.5 0.041 14.3 5.7 2.7 2 0 0 2 2 2 0 FERM central domain TPR_2 PF07719.17 EFC44816.1 - 0.68 10.2 4.9 18 5.8 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Actin PF00022.19 EFC44817.1 - 1.9e-146 487.9 0.0 7.5e-146 485.9 0.0 1.7 1 1 0 1 1 1 1 Actin RCC1 PF00415.18 EFC44818.1 - 2.2e-20 73.0 10.9 2.7e-08 34.3 0.2 6.6 5 1 1 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC44818.1 - 6.1e-15 54.6 10.6 2.9e-06 26.9 0.4 5.8 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Kelch_5 PF13854.6 EFC44818.1 - 2.5e-10 40.1 6.6 0.0038 17.2 0.1 4.9 4 0 0 4 4 4 2 Kelch motif RGS PF00615.19 EFC44818.1 - 6.2e-09 36.1 2.1 3.1e-08 33.9 2.1 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain Kelch_6 PF13964.6 EFC44818.1 - 8.3e-08 32.3 1.9 0.0014 18.9 0.0 4.8 3 1 1 4 4 4 1 Kelch motif Fibrinogen_C PF00147.18 EFC44818.1 - 3.8e-06 26.9 0.0 9.2e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain COLFI PF01410.18 EFC44818.1 - 0.0029 17.0 0.0 0.0074 15.6 0.0 1.7 1 0 0 1 1 1 1 Fibrillar collagen C-terminal domain Kelch_1 PF01344.25 EFC44818.1 - 0.0052 16.3 1.2 4.3 7.0 0.4 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 EFC44818.1 - 0.03 14.3 3.6 7.1 6.7 0.1 4.2 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC44818.1 - 0.69 10.3 7.3 3.6 8.0 0.1 3.8 3 1 0 3 3 3 0 Galactose oxidase, central domain TTL PF03133.15 EFC44819.1 - 8.5e-39 133.4 0.9 8.5e-39 133.4 0.9 1.9 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family Torus PF16131.5 EFC44819.1 - 0.042 14.6 0.2 0.11 13.2 0.2 1.7 1 0 0 1 1 1 0 Torus domain Sec23_trunk PF04811.15 EFC44820.1 - 7.9e-56 189.3 0.0 1.6e-55 188.4 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 EFC44820.1 - 1.4e-14 54.6 0.1 4.2e-14 53.0 0.1 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 EFC44820.1 - 2.3e-14 53.1 9.5 2.3e-14 53.1 9.5 2.2 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 EFC44820.1 - 2.6e-12 46.5 0.0 7.2e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 Sec23/Sec24 helical domain MRNIP PF15749.5 EFC44820.1 - 0.0045 17.7 0.5 0.011 16.5 0.5 1.6 1 0 0 1 1 1 1 MRN-interacting protein Gelsolin PF00626.22 EFC44820.1 - 0.0091 15.9 0.0 0.027 14.4 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Pox_A3L PF05288.11 EFC44820.1 - 0.055 13.5 0.0 0.19 11.7 0.0 1.9 1 0 0 1 1 1 0 Poxvirus A3L Protein EF-hand_1 PF00036.32 EFC44821.1 - 1.4e-12 46.2 0.1 1.5e-05 24.2 0.2 2.2 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC44821.1 - 1.7e-12 47.6 0.0 2.1e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC44821.1 - 6.4e-10 38.2 0.2 5.2e-05 22.8 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFC44821.1 - 4.8e-09 35.9 0.0 0.0009 19.0 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC44821.1 - 1.3e-07 30.8 0.2 0.0037 16.7 0.0 2.2 2 0 0 2 2 2 2 EF hand Guanylate_cyc PF00211.20 EFC44822.1 - 7.6e-25 87.6 0.0 8.8e-25 87.4 0.0 1.0 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain 3-alpha PF03475.14 EFC44822.1 - 0.073 12.9 0.4 0.17 11.8 0.4 1.6 1 0 0 1 1 1 0 3-alpha domain SET_assoc PF11767.8 EFC44822.1 - 0.074 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Actin PF00022.19 EFC44823.1 - 1.5e-100 336.7 0.0 1.8e-100 336.5 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC44823.1 - 0.19 10.5 0.0 1.3 7.7 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein DUF2222 PF09984.9 EFC44824.1 - 1.6 8.6 6.6 0.41 10.5 0.3 2.3 2 0 0 2 2 2 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) Thioredoxin PF00085.20 EFC44825.1 - 4.7e-27 94.0 0.2 1.3e-26 92.6 0.2 1.8 1 0 0 1 1 1 1 Thioredoxin UBX PF00789.20 EFC44825.1 - 4.4e-08 33.2 0.0 1.4e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 UBX domain Thioredoxin_2 PF13098.6 EFC44825.1 - 0.00025 21.5 0.1 0.00025 21.5 0.1 3.1 2 2 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFC44825.1 - 0.0005 20.3 0.1 0.0016 18.7 0.1 1.9 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 EFC44825.1 - 0.0014 18.8 0.0 0.0039 17.3 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 EFC44825.1 - 0.0016 18.4 0.1 0.0051 16.7 0.1 1.9 1 0 0 1 1 1 1 AhpC/TSA family OST3_OST6 PF04756.13 EFC44825.1 - 0.0081 15.5 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family ubiquitin PF00240.23 EFC44825.1 - 0.01 15.6 0.1 0.01 15.6 0.1 2.6 3 0 0 3 3 3 1 Ubiquitin family DUF572 PF04502.13 EFC44825.1 - 0.39 10.3 36.1 1.3 8.5 22.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) gerPA PF10676.9 EFC44825.1 - 2.8 8.2 4.9 7.9 6.8 4.9 1.8 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF C2 PF00168.30 EFC44826.1 - 0.00013 22.2 0.0 0.00013 22.2 0.0 2.3 2 0 0 2 2 2 1 C2 domain HTH_Mga PF08280.11 EFC44826.1 - 0.018 15.1 0.7 0.051 13.6 0.7 1.8 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain SlyX PF04102.12 EFC44826.1 - 1.1 9.9 7.0 0.21 12.2 0.9 3.0 2 0 0 2 2 2 0 SlyX XhlA PF10779.9 EFC44826.1 - 3.1 8.1 9.0 0.62 10.3 0.9 3.1 1 1 2 3 3 3 0 Haemolysin XhlA Metallophos PF00149.28 EFC44827.1 - 4e-12 47.1 3.3 5.9e-12 46.5 3.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase zf-met PF12874.7 EFC44827.1 - 0.32 11.5 2.6 7.6 7.1 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Esterase_phd PF10503.9 EFC44828.1 - 1.2e-10 41.2 2.7 2.1e-08 34.0 0.1 2.5 2 1 0 2 2 2 2 Esterase PHB depolymerase Peptidase_S9 PF00326.21 EFC44828.1 - 0.0001 21.9 0.0 0.00018 21.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 EFC44828.1 - 0.0062 16.5 0.2 0.048 13.6 0.2 2.1 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2207 PF09972.9 EFC44829.1 - 0.011 14.6 0.0 0.012 14.4 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_M56 PF05569.11 EFC44829.1 - 0.021 14.0 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 Amnionless PF14828.6 EFC44829.1 - 0.053 12.3 0.1 0.057 12.2 0.1 1.1 1 0 0 1 1 1 0 Amnionless S1FA PF04689.13 EFC44829.1 - 0.078 13.1 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 DNA binding protein S1FA Gram_pos_anchor PF00746.21 EFC44829.1 - 0.16 11.9 5.8 0.48 10.4 0.0 2.4 1 1 1 2 2 2 0 LPXTG cell wall anchor motif HATPase_c PF02518.26 EFC44830.1 - 6e-18 65.4 3.7 1.3e-16 61.1 2.6 3.0 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC44830.1 - 2.9e-17 62.8 0.2 7.5e-17 61.5 0.2 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC44830.1 - 5.8e-13 48.7 0.1 1.9e-12 47.0 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain ParBc PF02195.18 EFC44831.1 - 5.6e-08 33.0 0.0 7.9e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 ParB-like nuclease domain Kelch_1 PF01344.25 EFC44831.1 - 0.17 11.5 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Glycoprotein_G PF00802.19 EFC44833.1 - 0.13 11.6 6.5 0.23 10.8 6.5 1.3 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G Chordopox_G3 PF06129.12 EFC44833.1 - 0.16 12.7 2.2 0.19 12.4 0.7 2.0 2 0 0 2 2 2 0 Chordopoxvirus G3 protein Ank_2 PF12796.7 EFC44834.1 - 0.0014 19.2 6.8 0.0065 17.0 0.2 4.7 4 1 0 5 5 5 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC44834.1 - 0.006 17.1 0.4 33 5.2 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeats (many copies) SPC25 PF06703.11 EFC44836.1 - 1.1e-24 87.1 1.3 1.4e-24 86.7 1.3 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) GCR PF02155.15 EFC44836.1 - 0.053 12.6 0.1 0.076 12.1 0.1 1.1 1 0 0 1 1 1 0 Glucocorticoid receptor MIP-T3_C PF17749.1 EFC44837.1 - 4.1e-33 114.5 18.9 4.1e-33 114.5 18.9 2.7 3 1 0 3 3 3 1 Microtubule-binding protein MIP-T3 C-terminal region MIP-T3 PF10243.9 EFC44837.1 - 1.7e-21 76.3 1.5 1.7e-21 76.3 1.5 2.1 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 CH-like domain SWIRM-assoc_1 PF16495.5 EFC44837.1 - 0.015 15.3 2.1 0.015 15.3 2.1 3.2 4 0 0 4 4 4 0 SWIRM-associated region 1 Med28 PF11594.8 EFC44837.1 - 0.07 13.2 6.7 0.076 13.1 2.9 2.6 1 1 1 2 2 2 0 Mediator complex subunit 28 DUF1474 PF07342.11 EFC44837.1 - 0.76 10.3 5.5 0.68 10.5 1.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1474) CC2-LZ PF16516.5 EFC44837.1 - 5.7 7.4 16.8 0.72 10.3 3.2 3.8 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Gar1 PF04410.14 EFC44838.1 - 2.3e-08 34.0 26.2 1.1e-06 28.5 8.9 4.7 3 1 1 4 4 4 2 Gar1/Naf1 RNA binding region SAP PF02037.27 EFC44838.1 - 3.3e-06 26.7 0.2 6.7e-06 25.7 0.2 1.5 1 0 0 1 1 1 1 SAP domain LRR_6 PF13516.6 EFC44839.1 - 5.1e-11 41.7 30.9 0.0029 17.5 0.1 8.3 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EFC44839.1 - 5.5e-09 36.2 23.8 0.05 14.0 3.6 7.0 4 2 0 5 5 5 4 Leucine Rich repeats (2 copies) Cnd1 PF12717.7 EFC44839.1 - 0.0061 16.6 3.5 0.014 15.4 0.5 3.1 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 MRP-S26 PF14943.6 EFC44839.1 - 0.11 12.4 5.4 0.039 13.9 0.5 2.3 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 LRR_1 PF00560.33 EFC44839.1 - 4.6 8.2 24.2 2.7 8.9 0.0 8.2 9 0 0 9 9 9 0 Leucine Rich Repeat 6PF2K PF01591.18 EFC44840.1 - 0.0036 16.6 0.2 0.35 10.2 0.0 2.5 2 0 0 2 2 2 2 6-phosphofructo-2-kinase BA14K PF07886.11 EFC44840.1 - 0.24 11.3 1.0 0.48 10.3 1.0 1.5 1 0 0 1 1 1 0 BA14K-like protein Terminase_4 PF05119.12 EFC44841.1 - 0.14 12.6 1.2 0.5 10.8 0.3 2.2 2 0 0 2 2 2 0 Phage terminase, small subunit MFS_1 PF07690.16 EFC44842.1 - 1.1e-38 133.1 3.5 1.6e-38 132.6 3.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 EFC44842.1 - 5.2e-20 71.2 14.2 3e-19 68.7 5.4 3.4 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 EFC44842.1 - 2.9e-12 46.2 18.7 6.1e-11 41.8 4.6 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter UPF0242 PF06785.11 EFC44842.1 - 0.062 13.4 0.0 0.062 13.4 0.0 2.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus BTB PF00651.31 EFC44843.1 - 2.6e-11 43.8 0.1 4.2e-11 43.1 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain DUF4116 PF13475.6 EFC44845.1 - 8.8e-31 105.4 28.7 9.8e-09 34.8 0.8 7.7 4 1 3 8 8 8 6 Domain of unknown function (DUF4116) CxC7 PF18866.1 EFC44845.1 - 0.1 12.7 0.3 0.35 11.0 0.3 1.9 1 0 0 1 1 1 0 CxC7 like cysteine cluster associated with KDZ transposases HTH_54 PF18607.1 EFC44846.1 - 0.051 13.6 0.7 0.14 12.2 0.1 2.2 2 0 0 2 2 2 0 ParA helix turn helix domain Tetraspanin PF00335.20 EFC44848.1 - 0.0019 17.9 3.6 0.0019 17.9 3.6 2.1 1 1 1 2 2 2 1 Tetraspanin family OATP PF03137.20 EFC44848.1 - 0.0023 16.3 1.9 0.016 13.5 0.0 2.1 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family ArAE_2_N PF10337.9 EFC44848.1 - 0.014 14.4 0.1 0.014 14.4 0.1 2.2 3 0 0 3 3 3 0 Putative ER transporter, 6TM, N-terminal DUF4407 PF14362.6 EFC44848.1 - 0.12 11.7 0.2 0.24 10.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Tmemb_9 PF05434.11 EFC44848.1 - 0.33 10.8 3.2 1.6 8.6 0.0 2.6 2 0 0 2 2 2 0 TMEM9 DUF4131 PF13567.6 EFC44848.1 - 0.42 10.3 7.1 0.73 9.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) 7tm_7 PF08395.12 EFC44848.1 - 0.75 8.9 16.9 3.1 6.9 16.9 1.8 1 1 0 1 1 1 0 7tm Chemosensory receptor DHHC PF01529.20 EFC44848.1 - 1.8 8.7 22.0 5.1 7.2 9.8 3.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF4229 PF14012.6 EFC44848.1 - 5.3 7.2 14.8 0.31 11.2 4.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) Renin_r PF07850.14 EFC44848.1 - 6.7 7.4 11.1 13 6.4 0.0 3.5 3 1 0 3 3 3 0 Renin receptor-like protein NPM1-C PF16276.5 EFC44850.1 - 0.01 15.8 0.8 0.023 14.6 0.8 1.6 1 0 0 1 1 1 0 Nucleophosmin C-terminal domain STAG PF08514.11 EFC44850.1 - 0.017 15.0 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 STAG domain CRT-like PF08627.10 EFC44851.1 - 1.1e-65 221.8 25.8 1.4e-65 221.4 25.8 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 EFC44851.1 - 3.5e-06 26.4 14.9 2.4e-05 23.7 11.8 2.6 2 1 0 2 2 2 2 UAA transporter family C2 PF00168.30 EFC44852.1 - 3.2e-22 78.8 0.0 4.5e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 EFC44852.1 - 0.047 13.2 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 CEP76 C2 domain TFIIA PF03153.13 EFC44852.1 - 0.87 9.5 8.6 1 9.3 8.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RWP-RK PF02042.15 EFC44853.1 - 1.1e-09 38.1 0.0 2.2e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 RWP-RK domain DDHD PF02862.17 EFC44853.1 - 0.0021 18.3 7.7 0.0029 17.8 7.7 1.2 1 0 0 1 1 1 1 DDHD domain HTH_8 PF02954.19 EFC44853.1 - 0.025 14.4 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Utp14 PF04615.13 EFC44853.1 - 0.028 13.0 8.1 0.028 13.0 8.1 1.1 1 0 0 1 1 1 0 Utp14 protein Presenilin PF01080.17 EFC44853.1 - 0.056 12.2 12.2 0.088 11.6 12.2 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 EFC44853.1 - 0.61 8.8 14.2 0.94 8.2 14.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SRP-alpha_N PF04086.13 EFC44853.1 - 1.7 8.5 20.6 3.2 7.6 20.6 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal zf-C2H2 PF00096.26 EFC44854.1 - 3e-09 36.8 10.8 0.00054 20.3 0.3 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFC44854.1 - 1.6e-07 31.5 14.1 0.015 16.0 0.7 3.8 3 1 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFC44854.1 - 0.00019 21.6 8.1 0.82 10.0 0.1 3.3 2 1 1 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EFC44854.1 - 0.01 15.8 0.6 0.01 15.8 0.6 3.9 5 0 0 5 5 5 0 C2H2-type zinc finger zf-met PF12874.7 EFC44854.1 - 0.017 15.5 6.1 4.4 7.8 0.0 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EFC44854.1 - 0.093 12.3 9.8 4 7.1 0.1 3.5 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Actin PF00022.19 EFC44855.1 - 5.5e-100 334.8 0.0 6.2e-99 331.4 0.0 1.9 1 1 0 1 1 1 1 Actin DUF3437 PF11919.8 EFC44856.1 - 1.1e-33 115.0 0.2 1.4e-30 105.0 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF3437) HEAT PF02985.22 EFC44856.1 - 2.3e-06 27.4 0.1 0.0072 16.5 0.0 3.1 3 0 0 3 3 3 2 HEAT repeat HEAT_EZ PF13513.6 EFC44856.1 - 1.7e-05 25.2 0.0 0.32 11.6 0.0 2.4 2 0 0 2 2 2 2 HEAT-like repeat UNC45-central PF11701.8 EFC44856.1 - 6.3e-05 23.0 0.1 0.0024 17.9 0.0 2.1 1 1 1 2 2 2 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 EFC44856.1 - 9.4e-05 22.1 0.1 0.081 12.5 0.0 2.1 2 0 0 2 2 2 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 EFC44856.1 - 0.0016 19.0 0.0 1.3 9.7 0.0 2.4 2 1 0 2 2 2 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EFC44856.1 - 0.018 15.1 0.1 0.1 12.6 0.1 2.0 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Bac_DnaA PF00308.18 EFC44856.1 - 0.061 13.2 0.2 0.1 12.5 0.2 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein IBN_N PF03810.19 EFC44856.1 - 0.063 13.2 0.2 0.25 11.3 0.0 2.1 2 2 0 2 2 2 0 Importin-beta N-terminal domain HEAT_2 PF13646.6 EFC44856.1 - 0.094 13.1 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 HEAT repeats KH_1 PF00013.29 EFC44857.1 - 4e-28 97.0 28.0 5.8e-13 48.5 1.5 6.0 6 0 0 6 6 6 5 KH domain TPR_MLP1_2 PF07926.12 EFC44857.1 - 6.5e-05 23.0 9.8 6.5e-05 23.0 9.8 6.5 3 3 4 7 7 7 2 TPR/MLP1/MLP2-like protein KH_4 PF13083.6 EFC44857.1 - 0.0017 18.2 4.4 0.0031 17.3 0.0 3.7 3 0 0 3 3 3 1 KH domain Secretin_N PF03958.17 EFC44857.1 - 1.3 9.5 7.4 0.76 10.2 0.0 4.0 5 1 1 6 6 6 0 Bacterial type II/III secretion system short domain PARG_cat PF05028.14 EFC44858.1 - 1.9e-40 139.2 1.0 2.4e-40 138.8 1.0 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PMC2NT PF08066.12 EFC44858.1 - 0.12 13.0 1.2 0.32 11.7 0.2 2.2 2 0 0 2 2 2 0 PMC2NT (NUC016) domain Propep_M14 PF02244.16 EFC44859.1 - 0.021 15.2 0.3 0.056 13.8 0.1 1.8 2 0 0 2 2 2 0 Carboxypeptidase activation peptide Hydrolase_4 PF12146.8 EFC44860.1 - 0.002 17.4 0.0 0.002 17.4 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Hydrolase_4 PF12146.8 EFC44861.1 - 0.028 13.7 0.1 0.081 12.2 0.1 1.7 1 1 0 1 1 1 0 Serine aminopeptidase, S33 RGS12_usC PF16612.5 EFC44862.1 - 0.058 13.8 0.1 0.21 12.0 0.0 1.8 2 0 0 2 2 2 0 C-terminal unstructured region of RGS12 Noelin-1 PF12308.8 EFC44862.1 - 0.94 9.5 7.5 1.4 8.9 2.2 2.2 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF4407 PF14362.6 EFC44862.1 - 1.8 7.8 4.9 2.5 7.4 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WGR PF05406.15 EFC44863.1 - 1.2e-05 25.3 0.0 2.8e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 WGR domain PAP_fibrillin PF04755.12 EFC44863.1 - 0.74 9.7 5.5 0.32 10.9 0.3 2.7 3 0 0 3 3 3 0 PAP_fibrillin BTB PF00651.31 EFC44864.1 - 4.2e-09 36.6 1.9 6.5e-09 36.0 1.3 1.7 1 1 0 1 1 1 1 BTB/POZ domain CENP-F_leu_zip PF10473.9 EFC44865.1 - 0.0026 17.8 55.6 0.076 13.0 10.3 4.0 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 EFC44865.1 - 0.011 15.8 31.1 0.011 15.8 31.1 3.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 EFC44865.1 - 0.06 13.4 49.3 0.19 11.8 17.7 3.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Sugarporin_N PF11471.8 EFC44865.1 - 0.44 10.5 0.0 0.44 10.5 0.0 3.9 4 0 0 4 4 4 0 Maltoporin periplasmic N-terminal extension Golgin_A5 PF09787.9 EFC44865.1 - 0.67 9.4 45.8 0.026 14.0 22.4 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 FUSC PF04632.12 EFC44865.1 - 0.75 8.3 1.4 1.1 7.7 1.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3584 PF12128.8 EFC44865.1 - 0.93 6.9 40.6 1.2 6.6 38.8 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3584) HMMR_N PF15905.5 EFC44865.1 - 0.99 8.8 54.4 0.1 12.1 42.7 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal kleA_kleC PF17383.2 EFC44865.1 - 1.1 9.6 6.3 1.1 9.6 2.8 2.6 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A Nup54 PF13874.6 EFC44865.1 - 1.6 8.8 32.0 0.1 12.7 17.7 3.4 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 MAD PF05557.13 EFC44865.1 - 4.7 5.4 50.8 0.26 9.6 16.5 2.7 1 1 1 2 2 2 0 Mitotic checkpoint protein Spc7 PF08317.11 EFC44865.1 - 6.2 5.6 51.6 1.5 7.6 22.8 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Vac_Fusion PF02346.16 EFC44865.1 - 6.7 6.4 11.5 2.7 7.7 0.1 4.0 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 APG6_N PF17675.1 EFC44865.1 - 8.3 7.0 53.7 2.2 8.8 29.4 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region GAS PF13851.6 EFC44865.1 - 8.7 5.6 54.2 15 4.9 16.1 3.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Tropomyosin PF00261.20 EFC44865.1 - 9 5.6 53.4 0.43 9.9 2.3 2.6 1 1 1 2 2 2 0 Tropomyosin V-SNARE_C PF12352.8 EFC44867.1 - 5.2e-09 36.3 7.5 5.2e-09 36.3 7.5 2.1 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus HK_sensor PF16750.5 EFC44867.1 - 0.045 14.0 0.2 0.12 12.6 0.1 1.9 1 1 0 1 1 1 0 Sensor domain of 2-component histidine kinase DUF3976 PF13121.6 EFC44867.1 - 0.057 13.6 2.4 0.093 12.9 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3976) Sec20 PF03908.13 EFC44867.1 - 0.07 13.1 0.5 0.07 13.1 0.5 2.5 2 1 0 2 2 2 0 Sec20 GP41 PF00517.17 EFC44867.1 - 0.074 13.0 0.1 0.074 13.0 0.1 2.3 2 1 0 2 2 2 0 Retroviral envelope protein Tweety PF04906.13 EFC44867.1 - 1.4 7.5 9.9 5.4 5.6 0.1 2.2 2 0 0 2 2 2 0 Tweety DUF745 PF05335.13 EFC44867.1 - 3.2 7.4 7.1 3.1 7.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) PH PF00169.29 EFC44868.1 - 8.2e-15 55.2 4.7 1.1e-14 54.9 0.1 2.8 2 1 1 3 3 3 1 PH domain PH_11 PF15413.6 EFC44868.1 - 5.5e-08 33.2 0.1 5.5e-08 33.2 0.1 2.8 2 1 1 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.6 EFC44868.1 - 1.6e-05 25.1 0.1 6.1e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain GCR1_C PF12550.8 EFC44868.1 - 1.1 9.7 4.8 1.8 9.0 1.0 2.7 3 0 0 3 3 3 0 Transcriptional activator of glycolytic enzymes NGP1NT PF08153.12 EFC44869.1 - 7.1e-42 142.6 0.6 1.8e-41 141.3 0.6 1.7 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 EFC44869.1 - 1.8e-15 57.0 0.0 7.5e-13 48.6 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC44869.1 - 0.00039 20.4 0.0 0.0016 18.4 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFC44869.1 - 0.00041 19.9 0.1 0.0011 18.5 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_16 PF13191.6 EFC44869.1 - 0.021 15.2 0.0 0.065 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 EFC44869.1 - 0.032 14.3 0.1 4.4 7.3 0.0 3.6 2 1 1 3 3 3 0 Dynamin family GTP_EFTU PF00009.27 EFC44869.1 - 0.055 13.0 0.0 1.6 8.2 0.0 2.7 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 EFC44869.1 - 0.22 12.1 2.3 0.9 10.1 0.0 2.9 3 1 0 3 3 3 0 AAA domain Nop14 PF04147.12 EFC44869.1 - 0.27 9.4 13.5 0.45 8.7 13.5 1.3 1 0 0 1 1 1 0 Nop14-like family HSP70 PF00012.20 EFC44870.1 - 3.1e-99 332.8 0.0 3.5e-99 332.7 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC44870.1 - 2.4e-05 23.3 0.0 7e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 MreB/Mbl protein ABC_membrane PF00664.23 EFC44871.1 - 1.5e-41 142.9 14.2 2.2e-41 142.3 14.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC44871.1 - 1.5e-33 116.2 0.0 4.2e-33 114.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC44871.1 - 1.1e-07 31.5 0.2 0.00014 21.4 0.0 2.5 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC44871.1 - 0.0012 18.5 1.5 0.0018 18.0 0.3 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EFC44871.1 - 0.0014 18.5 1.6 0.0017 18.1 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 EFC44871.1 - 0.002 18.5 0.8 0.0068 16.8 0.2 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFC44871.1 - 0.0052 17.1 0.4 0.06 13.6 0.4 2.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC44871.1 - 0.0094 16.4 0.4 1.7 9.1 0.1 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 EFC44871.1 - 0.0099 14.7 0.3 0.039 12.8 0.0 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EFC44871.1 - 0.01 15.7 0.0 0.025 14.5 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 EFC44871.1 - 0.021 14.4 0.0 0.62 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFC44871.1 - 0.052 13.3 0.2 0.38 10.4 0.2 2.3 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EFC44871.1 - 0.055 13.3 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 EFC44871.1 - 0.056 14.0 0.2 0.23 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFC44871.1 - 0.061 13.2 0.1 0.42 10.5 0.0 2.4 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_5 PF07728.14 EFC44871.1 - 0.089 12.8 0.1 0.52 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EFC44871.1 - 0.4 11.2 0.1 0.4 11.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain RCC1_2 PF13540.6 EFC44872.1 - 2.7e-26 90.7 6.5 1.2e-06 28.2 0.0 5.8 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC44872.1 - 2.3e-20 72.9 1.8 0.00021 21.9 0.0 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 EFC44872.1 - 0.13 12.3 0.0 5.3 7.1 0.0 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain VID27 PF08553.10 EFC44873.1 - 3.1e-82 276.5 0.7 6.5e-82 275.4 0.7 1.5 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_PH PF17747.1 EFC44873.1 - 3.1e-15 56.4 2.2 9.8e-15 54.8 2.2 1.9 1 0 0 1 1 1 1 VID27 PH-like domain PBP1_TM PF14812.6 EFC44873.1 - 9.4 6.7 8.2 0.74 10.2 0.5 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Fibrinogen_C PF00147.18 EFC44874.1 - 0.00023 21.1 0.3 0.00027 20.8 0.3 1.3 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain IU_nuc_hydro PF01156.19 EFC44876.1 - 1.8e-31 109.9 0.0 2.4e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Lipocalin_2 PF08212.12 EFC44877.1 - 3.2e-23 82.3 0.0 4.1e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Lipocalin-like domain Lipocalin PF00061.23 EFC44877.1 - 4.4e-13 49.6 0.0 8e-13 48.8 0.0 1.4 2 0 0 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family Triabin PF03973.13 EFC44877.1 - 0.0012 18.7 0.2 0.002 18.0 0.2 1.5 1 1 0 1 1 1 1 Triabin VDE PF07137.11 EFC44877.1 - 0.024 14.1 0.1 0.2 11.2 0.0 2.0 2 0 0 2 2 2 0 VDE lipocalin domain SR-25 PF10500.9 EFC44878.1 - 0.014 15.0 5.1 0.014 15.0 5.1 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Guanylate_cyc_2 PF09778.9 EFC44878.1 - 0.074 12.4 3.2 2.4 7.5 3.2 2.3 1 1 0 1 1 1 0 Guanylylate cyclase IMUP PF15761.5 EFC44878.1 - 3.9 8.2 7.4 4.6 8.0 4.2 2.4 3 0 0 3 3 3 0 Immortalisation up-regulated protein Peptidase_C1 PF00112.23 EFC44879.1 - 1.3e-64 218.3 5.5 1.3e-64 218.3 5.5 1.6 2 0 0 2 2 2 1 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC44879.1 - 6e-08 32.4 0.1 1.2e-07 31.5 0.1 1.5 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C1_2 PF03051.15 EFC44879.1 - 0.00035 19.5 8.2 0.09 11.5 0.2 3.1 2 1 1 3 3 3 3 Peptidase C1-like family GGGtGRT PF14057.6 EFC44879.1 - 0.098 11.6 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 GGGtGRT protein AAA-ATPase_like PF09820.9 EFC44880.1 - 5.7e-45 153.9 8.1 1e-44 153.1 7.1 1.8 2 0 0 2 2 2 1 Predicted AAA-ATPase AAA_22 PF13401.6 EFC44880.1 - 0.025 14.8 0.1 0.057 13.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain Ank_2 PF12796.7 EFC44881.1 - 4.8e-27 94.4 0.1 1.9e-12 47.6 0.0 3.3 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC44881.1 - 2.7e-20 70.3 0.2 0.00025 21.2 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFC44881.1 - 1.3e-17 63.9 0.1 2.5e-07 31.1 0.0 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC44881.1 - 1e-14 54.2 0.0 0.011 16.1 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 EFC44881.1 - 3.8e-12 46.2 0.1 0.009 16.3 0.0 4.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) DUF962 PF06127.11 EFC44882.1 - 4.6e-32 110.0 0.5 5.1e-32 109.8 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF962) DOMON PF03351.17 EFC44883.1 - 7.8e-08 32.6 1.1 9.3e-07 29.1 0.0 2.1 1 1 1 2 2 2 1 DOMON domain DOMON PF03351.17 EFC44884.1 - 2.1e-08 34.4 0.0 3.3e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 DOMON domain SKG6 PF08693.10 EFC44884.1 - 2.7 7.5 6.0 6.6 6.2 6.0 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Aa_trans PF01490.18 EFC44886.1 - 5.4e-38 130.8 28.6 6.5e-38 130.5 28.6 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Guanylate_cyc PF00211.20 EFC44887.1 - 1.4e-19 70.4 0.0 1.7e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RRM_1 PF00076.22 EFC44888.1 - 2.2e-11 43.4 0.0 3.3e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFC44888.1 - 0.026 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif LRR_4 PF12799.7 EFC44889.1 - 5.1e-23 80.8 54.6 7.1e-06 26.3 9.7 7.4 3 2 7 10 10 10 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC44889.1 - 5.2e-22 76.0 43.3 0.00091 19.1 1.2 11.5 12 1 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC44889.1 - 6e-13 48.3 48.1 0.0064 16.2 1.7 7.5 4 2 3 7 7 7 7 Leucine rich repeat LRR_1 PF00560.33 EFC44889.1 - 9.2e-11 40.8 43.7 0.53 11.0 0.7 11.3 11 1 0 11 11 11 6 Leucine Rich Repeat F-box PF00646.33 EFC44889.1 - 0.00095 19.0 1.8 0.0081 16.0 0.7 2.7 2 0 0 2 2 2 1 F-box domain DUF4957 PF16318.5 EFC44889.1 - 0.0012 18.7 1.8 0.0012 18.7 1.8 2.8 1 1 2 3 3 3 1 Domain of unknown function (DUF4957) F-box-like PF12937.7 EFC44889.1 - 0.03 14.2 0.0 0.097 12.6 0.0 1.9 1 0 0 1 1 1 0 F-box-like Apt1 PF10351.9 EFC44890.1 - 0.79 8.5 3.8 0.81 8.5 3.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 EFC44890.1 - 1 7.8 7.9 1.2 7.6 7.9 1.0 1 0 0 1 1 1 0 Macoilin family p450 PF00067.22 EFC44891.1 - 2.5e-65 221.1 1.2 2.9e-65 220.8 1.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 PEPCK_N PF17297.2 EFC44891.1 - 0.09 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain LNS2 PF08235.13 EFC44893.1 - 1.4e-75 253.7 0.0 2.2e-75 253.0 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EFC44893.1 - 3.1e-09 36.7 0.1 6.5e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Neur_chan_memb PF02932.16 EFC44893.1 - 0.72 9.9 4.5 0.44 10.6 2.4 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CENP-H PF05837.12 EFC44893.1 - 2.9 8.3 5.0 6.7 7.2 5.0 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4116 PF13475.6 EFC44896.1 - 1.5e-48 162.2 0.0 2.2e-09 36.9 0.0 6.8 6 1 1 7 7 7 6 Domain of unknown function (DUF4116) PP2C PF00481.21 EFC44896.1 - 5.9e-23 81.8 0.0 1.2e-22 80.8 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C zf-RING_2 PF13639.6 EFC44897.1 - 3.5e-14 52.8 14.3 5.1e-14 52.3 14.3 1.2 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFC44897.1 - 2e-09 37.0 9.9 3.9e-09 36.1 9.9 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFC44897.1 - 2.3e-09 37.0 13.0 3.3e-09 36.4 13.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFC44897.1 - 1.1e-08 35.3 17.2 1.3e-08 35.0 17.2 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFC44897.1 - 6.6e-07 29.3 9.6 1e-06 28.6 9.6 1.3 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 EFC44897.1 - 7.8e-07 28.9 13.3 1.1e-06 28.4 13.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC44897.1 - 2.7e-06 27.3 11.9 4.1e-06 26.7 11.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 EFC44897.1 - 5.7e-05 23.1 10.1 6.4e-05 22.9 10.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 EFC44897.1 - 0.00014 21.7 14.0 0.0005 19.9 14.4 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC44897.1 - 0.00029 20.6 11.7 0.00029 20.6 11.7 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 EFC44897.1 - 0.0062 16.1 14.4 0.0093 15.6 14.2 1.5 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 EFC44897.1 - 0.0074 16.5 3.0 0.0074 16.5 3.0 1.8 1 1 1 2 2 2 1 Zinc-ribbon like family RINGv PF12906.7 EFC44897.1 - 0.053 13.7 11.3 0.16 12.1 11.3 1.7 1 1 0 1 1 1 0 RING-variant domain UPF0547 PF10571.9 EFC44897.1 - 0.075 13.1 9.4 2 8.6 0.2 3.2 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-P11 PF03854.14 EFC44897.1 - 0.087 12.5 9.6 0.13 12.0 9.6 1.3 1 1 0 1 1 1 0 P-11 zinc finger Baculo_RING PF05883.11 EFC44897.1 - 0.14 12.1 4.1 0.18 11.8 4.1 1.2 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain zf-RING_4 PF14570.6 EFC44897.1 - 0.18 11.6 15.7 0.94 9.3 13.3 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Rtf2 PF04641.12 EFC44897.1 - 0.22 10.9 4.0 0.29 10.5 4.0 1.3 1 1 0 1 1 1 0 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 EFC44897.1 - 1.9 8.7 15.1 3.5 7.9 12.5 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Tmpp129 PF10272.9 EFC44897.1 - 3.5 6.9 10.9 4.2 6.6 10.9 1.2 1 1 0 1 1 1 0 Putative transmembrane protein precursor FANCL_C PF11793.8 EFC44897.1 - 3.8 7.8 14.1 31 4.9 14.1 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain 14-3-3 PF00244.20 EFC44898.1 - 1.5e-41 142.3 3.4 1.7e-41 142.2 3.4 1.0 1 0 0 1 1 1 1 14-3-3 protein DegS PF05384.11 EFC44898.1 - 0.026 14.0 2.1 0.068 12.7 0.0 2.2 2 0 0 2 2 2 0 Sensor protein DegS Mpv17_PMP22 PF04117.12 EFC44899.1 - 2.7e-11 43.5 4.6 2.8e-11 43.5 0.9 2.5 2 0 0 2 2 2 1 Mpv17 / PMP22 family N2227 PF07942.12 EFC44900.1 - 4.8e-93 311.3 1.0 5.9e-93 311.0 1.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 EFC44900.1 - 0.002 18.0 0.0 0.014 15.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 EFC44900.1 - 0.0049 16.1 0.0 0.0065 15.7 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_12 PF08242.12 EFC44900.1 - 0.014 16.2 0.0 0.12 13.2 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain KAP PF05804.12 EFC44901.1 - 1.1e-100 337.9 26.2 3.2e-100 336.3 26.2 1.7 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) RhoGAP PF00620.27 EFC44901.1 - 0.051 13.4 0.4 0.29 11.0 0.2 2.4 2 0 0 2 2 2 0 RhoGAP domain DUF1323 PF07037.11 EFC44901.1 - 0.18 12.2 0.4 7.8 6.9 0.2 2.6 1 1 1 2 2 2 0 Putative transcription regulator (DUF1323) Nipped-B_C PF12830.7 EFC44901.1 - 0.75 9.7 5.4 11 5.9 0.1 3.5 3 1 0 3 3 3 0 Sister chromatid cohesion C-terminus Drf_GBD PF06371.13 EFC44901.1 - 3.3 7.2 9.9 1.7 8.2 3.1 2.8 2 2 0 2 2 2 0 Diaphanous GTPase-binding Domain CLTH PF10607.9 EFC44902.1 - 7.7e-35 120.0 1.0 1.1e-34 119.5 1.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 EFC44902.1 - 2.5e-10 39.9 0.1 1.1e-09 37.9 0.1 2.1 2 0 0 2 2 2 1 LisH Sigma54_AID PF00309.20 EFC44902.1 - 2.9 7.8 10.2 0.42 10.5 4.5 2.4 2 0 0 2 2 2 0 Sigma-54 factor, Activator interacting domain (AID) IF4E PF01652.18 EFC44903.1 - 2.6e-40 137.8 2.1 3.5e-40 137.4 2.1 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Na_Ca_ex PF01699.24 EFC44904.1 - 1.6e-18 67.1 39.8 1.5e-12 47.7 19.3 4.2 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 EFC44904.1 - 8e-16 58.5 13.3 8e-16 58.5 13.3 5.8 6 0 0 6 6 6 2 Inner membrane component domain Pkinase PF00069.25 EFC44905.1 - 6.6e-60 202.7 0.0 8.1e-60 202.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44905.1 - 9e-29 100.5 0.0 1.2e-28 100.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC44905.1 - 1.2e-05 24.8 0.0 4.7e-05 22.9 0.0 1.8 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 EFC44905.1 - 3.8e-05 23.7 0.1 0.072 13.0 0.6 2.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC44905.1 - 0.00065 18.8 0.3 0.0012 18.0 0.3 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 EFC44905.1 - 0.0016 17.3 0.1 0.0024 16.7 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFC44905.1 - 0.0036 16.9 0.1 0.71 9.4 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 EFC44905.1 - 0.018 14.0 0.2 0.03 13.3 0.2 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 EFC44905.1 - 0.073 12.4 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 EFC44907.1 - 4.6e-17 62.1 30.1 8.1e-06 26.5 0.9 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat WD40_like PF17005.5 EFC44907.1 - 1.4e-05 24.5 11.0 0.00021 20.7 8.1 3.0 2 1 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 EFC44907.1 - 0.0016 18.7 0.4 0.03 14.6 0.1 2.8 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC44907.1 - 0.0033 16.1 5.7 0.29 9.7 0.1 3.7 2 1 1 4 4 4 2 Nucleoporin Nup120/160 PQQ_3 PF13570.6 EFC44907.1 - 0.03 14.8 0.0 18 6.0 0.0 3.9 4 0 0 4 4 4 0 PQQ-like domain JAB PF01398.21 EFC44908.1 - 6.7e-32 109.9 0.2 1.8e-31 108.6 0.0 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 EFC44908.1 - 1.6e-10 41.4 1.5 2.5e-10 40.8 1.5 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 EFC44908.1 - 1e-05 25.3 0.0 2.3e-05 24.2 0.0 1.6 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain RhoGAP PF00620.27 EFC44909.1 - 8.8e-23 80.8 0.0 1.9e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 EFC44909.1 - 1e-08 35.0 0.0 2.1e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5638 PF18688.1 EFC44909.1 - 2.8 8.3 7.2 7 7.0 0.6 3.5 4 0 0 4 4 4 0 Family of unknown function (DUF5638) NIR_SIR PF01077.22 EFC44912.1 - 0.00032 20.2 0.0 0.0004 19.9 0.0 1.2 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain DGCR6 PF07324.11 EFC44912.1 - 0.0011 18.6 0.2 0.0018 17.9 0.2 1.3 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF4230 PF14014.6 EFC44912.1 - 0.024 14.9 0.6 0.045 14.0 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) HIP1_clath_bdg PF16515.5 EFC44912.1 - 0.15 12.7 5.7 0.3 11.7 5.7 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SlyX PF04102.12 EFC44912.1 - 0.17 12.5 1.9 0.36 11.5 1.9 1.5 1 0 0 1 1 1 0 SlyX Trypan_PARP PF05887.11 EFC44914.1 - 6.9e-07 29.3 89.1 0.0052 16.8 41.1 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) GP63 PF17471.2 EFC44915.1 - 0.11 12.7 0.1 4 7.7 0.0 2.3 2 0 0 2 2 2 0 Gene product 63 U3_snoRNA_assoc PF08297.11 EFC44915.1 - 0.14 12.9 0.5 0.21 12.3 0.5 1.2 1 0 0 1 1 1 0 U3 snoRNA associated DUF924 PF06041.11 EFC44916.1 - 9.5e-32 110.6 0.6 1.2e-31 110.2 0.6 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) OAD_gamma PF04277.13 EFC44917.1 - 0.047 14.3 0.0 0.1 13.2 0.0 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4576 PF15144.6 EFC44917.1 - 0.06 13.2 0.1 0.28 11.1 0.0 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4576) CRAL_TRIO PF00650.20 EFC44918.1 - 9.7e-35 119.6 0.1 2.5e-34 118.3 0.0 1.6 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFC44918.1 - 4.6e-07 30.1 0.0 5.9e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC44918.1 - 2e-05 24.7 0.2 3.8e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain UvrD-helicase PF00580.21 EFC44919.1 - 4.9e-07 29.6 2.6 4.9e-07 29.6 2.6 4.0 2 2 0 3 3 3 1 UvrD/REP helicase N-terminal domain Glyco_trans_1_3 PF13528.6 EFC44919.1 - 0.14 11.4 0.0 0.48 9.6 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 1 PLA2G12 PF06951.11 EFC44920.1 - 6.3e-15 55.6 11.1 8.5e-15 55.1 11.1 1.2 1 0 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) Phospholip_A2_3 PF09056.11 EFC44920.1 - 3.5 8.3 11.9 2.3 8.9 6.8 2.5 1 1 1 2 2 2 0 Prokaryotic phospholipase A2 BTB PF00651.31 EFC44921.1 - 9.6e-10 38.7 0.0 2.3e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain LRR_6 PF13516.6 EFC44922.1 - 1.1e-24 84.4 21.3 3e-06 26.8 0.1 9.3 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.7 EFC44922.1 - 4.5e-20 71.4 14.4 0.00088 19.6 0.0 6.2 3 1 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC44922.1 - 1.5e-16 59.9 7.6 1.4e-06 28.0 0.0 5.0 4 2 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC44922.1 - 1.4e-09 37.2 6.0 0.45 11.3 0.1 7.9 8 2 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC44922.1 - 2.5e-07 30.4 3.2 0.012 15.1 0.0 3.6 1 1 2 4 4 4 2 Leucine-rich repeat UAA PF08449.11 EFC44923.1 - 1.2e-78 264.3 29.1 1.6e-78 264.0 29.1 1.0 1 0 0 1 1 1 1 UAA transporter family DUF3188 PF11384.8 EFC44923.1 - 0.0015 18.2 0.6 0.0015 18.2 0.6 3.0 4 0 0 4 4 4 1 Protein of unknown function (DUF3188) EamA PF00892.20 EFC44923.1 - 0.013 15.7 29.4 0.11 12.7 9.2 2.6 2 1 0 2 2 2 0 EamA-like transporter family DUF3311 PF11755.8 EFC44923.1 - 0.018 14.9 2.1 0.41 10.6 0.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3311) DUF3185 PF11381.8 EFC44923.1 - 0.093 12.8 1.3 0.35 10.9 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) Exo_endo_phos PF03372.23 EFC44924.1 - 1.3e-08 34.7 0.0 5.3e-08 32.7 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RL11D PF11088.8 EFC44924.1 - 0.0036 17.5 0.0 0.0089 16.3 0.0 1.6 1 0 0 1 1 1 1 Glycoprotein encoding membrane proteins RL5A and RL6 Pyocin_S PF06958.12 EFC44924.1 - 0.16 12.5 1.3 0.21 12.1 0.1 1.8 2 0 0 2 2 2 0 S-type Pyocin Vpu PF00558.19 EFC44924.1 - 0.63 9.9 2.0 21 4.9 0.1 2.4 2 0 0 2 2 2 0 Vpu protein COPI_assoc PF08507.10 EFC44925.1 - 2.2e-25 89.2 6.9 2.6e-25 88.9 6.9 1.1 1 0 0 1 1 1 1 COPI associated protein NADH_B2 PF14813.6 EFC44926.1 - 0.0046 16.7 0.0 0.01 15.6 0.0 1.7 1 1 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 GSH_synth_ATP PF03917.17 EFC44927.1 - 3.7e-105 351.8 0.6 4.2e-105 351.6 0.6 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 EFC44927.1 - 1.3e-30 105.8 0.0 4.3e-30 104.2 0.0 1.9 1 0 0 1 1 1 1 Eukaryotic glutathione synthase DUF1043 PF06295.12 EFC44927.1 - 0.32 11.0 3.2 0.37 10.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) Adaptin_binding PF10199.9 EFC44928.1 - 2.7 8.6 5.6 22 5.7 5.6 2.0 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 PBP1_TM PF14812.6 EFC44928.1 - 8.6 6.8 8.5 4.2 7.8 6.2 1.8 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Methyltransf_23 PF13489.6 EFC44930.1 - 0.044 13.6 0.1 0.09 12.6 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain LEDGF PF11467.8 EFC44930.1 - 0.11 12.1 2.3 5.6 6.6 0.0 3.2 3 0 0 3 3 3 0 Lens epithelium-derived growth factor (LEDGF) Tfb5 PF06331.12 EFC44930.1 - 0.5 10.4 4.6 0.46 10.5 0.2 2.8 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 adh_short PF00106.25 EFC44931.1 - 3.6e-26 91.8 0.3 3.5e-24 85.3 0.3 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC44931.1 - 4.2e-22 78.8 0.0 4.6e-21 75.5 0.0 2.0 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC44931.1 - 2.2e-05 24.4 0.1 3.5e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Oxidored_nitro PF00148.19 EFC44931.1 - 0.032 12.9 0.1 0.046 12.4 0.1 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase LtuB PF17455.2 EFC44932.1 - 0.098 13.3 1.3 20 5.9 0.0 2.7 2 0 0 2 2 2 0 Late transcription unit B ABC_tran PF00005.27 EFC44933.1 - 9.3e-22 78.0 0.1 2.3e-21 76.7 0.1 1.7 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EFC44933.1 - 3.4e-10 39.7 16.0 3.4e-10 39.7 16.0 3.5 4 0 0 4 4 4 1 ABC-2 type transporter SMC_N PF02463.19 EFC44933.1 - 7.7e-05 22.2 2.9 0.021 14.2 2.9 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFC44933.1 - 0.00061 19.7 0.2 0.099 12.4 0.0 2.7 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC44933.1 - 0.011 15.7 1.9 0.011 15.7 0.2 1.8 2 0 0 2 2 2 0 RsgA GTPase DUF87 PF01935.17 EFC44933.1 - 0.039 14.0 0.4 0.039 14.0 0.4 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_18 PF13238.6 EFC44933.1 - 0.066 13.8 0.2 1.1 9.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 EFC44933.1 - 0.09 11.8 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 EFC44933.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF5412 PF17428.2 EFC44933.1 - 2.6 7.9 6.8 5.4 6.9 0.6 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5412) DHC_N1 PF08385.12 EFC44934.1 - 3.7e-157 524.4 20.5 3.7e-157 524.4 20.5 5.3 5 1 1 6 6 6 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EFC44934.1 - 6.2e-128 426.4 0.1 8.2e-126 419.4 0.0 3.1 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC44934.1 - 1.2e-115 386.9 13.6 1.2e-115 386.9 13.6 5.8 7 1 0 7 7 7 2 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFC44934.1 - 8.8e-96 320.2 0.0 1.5e-94 316.2 0.0 2.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFC44934.1 - 1.5e-86 290.4 0.2 1.5e-86 290.4 0.2 3.3 4 0 0 4 4 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFC44934.1 - 2.8e-77 258.8 5.2 2.8e-77 258.8 5.2 4.7 4 0 0 4 4 3 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFC44934.1 - 4.4e-64 215.3 7.8 9.4e-61 204.5 0.1 4.5 4 1 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC44934.1 - 1.3e-51 174.7 0.1 5.8e-51 172.6 0.1 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 EFC44934.1 - 1.2e-43 149.5 13.3 4e-43 147.7 13.3 1.9 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EFC44934.1 - 2.1e-40 137.5 0.2 3.5e-39 133.6 0.1 3.4 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 EFC44934.1 - 1.3e-24 86.3 0.1 1.4e-23 83.0 0.1 2.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 EFC44934.1 - 1.6e-22 80.0 0.1 4.7e-08 33.1 0.0 5.7 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EFC44934.1 - 1.4e-21 76.9 0.2 1.4e-21 76.9 0.2 3.9 4 0 0 4 4 3 1 Dynein heavy chain AAA lid domain AAA PF00004.29 EFC44934.1 - 3e-08 34.2 1.4 0.14 12.6 0.0 5.1 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC44934.1 - 2e-06 28.3 3.6 0.21 12.0 0.0 6.0 6 0 0 6 6 4 2 AAA ATPase domain AAA_22 PF13401.6 EFC44934.1 - 0.00016 21.9 8.3 0.62 10.3 0.0 5.3 4 0 0 4 4 4 1 AAA domain Mg_chelatase PF01078.21 EFC44934.1 - 0.01 15.2 0.1 7.2 5.9 0.0 3.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 EFC44934.1 - 0.017 15.5 2.4 1.8 9.0 0.1 3.9 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 EFC44934.1 - 0.07 13.3 0.0 3.7 7.7 0.0 3.6 3 0 0 3 3 3 0 AAA domain DUF4407 PF14362.6 EFC44934.1 - 0.15 11.4 25.7 0.62 9.4 14.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) AAA_29 PF13555.6 EFC44934.1 - 0.24 11.2 0.7 19 5.1 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 EFC44934.1 - 0.98 9.1 5.6 1.4 8.6 0.0 3.5 4 0 0 4 4 4 0 Sigma-54 interaction domain AAA_19 PF13245.6 EFC44934.1 - 1.2 9.5 5.6 9.7 6.5 0.0 4.2 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFC44934.1 - 2.4 8.7 6.2 6.1 7.4 0.0 4.7 4 0 0 4 4 4 0 ABC transporter DUF3198 PF11433.8 EFC44934.1 - 3.2 7.7 9.9 16 5.5 0.0 5.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3198) tRNA-synt_2d PF01409.20 EFC44935.1 - 9.7e-87 290.5 0.0 1.4e-86 290.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD1 PF18552.1 EFC44935.1 - 1.5e-07 31.0 0.3 4.1e-07 29.7 0.3 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 1 PheRS_DBD3 PF18553.1 EFC44935.1 - 3.6e-07 30.4 1.3 9.7e-07 29.0 0.1 2.4 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 EFC44935.1 - 7.3e-05 22.3 0.0 0.012 15.0 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 EFC44935.1 - 0.0082 15.3 0.7 0.027 13.6 0.1 2.0 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) zf-MYND PF01753.18 EFC44936.1 - 3.7e-11 42.9 16.2 8.2e-11 41.8 16.2 1.6 1 0 0 1 1 1 1 MYND finger TPR_2 PF07719.17 EFC44936.1 - 1.7e-09 37.0 4.0 0.023 14.8 0.1 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC44936.1 - 1.1e-06 28.2 10.8 0.007 16.1 0.2 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC44936.1 - 0.0013 19.2 2.5 0.13 12.8 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC44936.1 - 0.0033 17.5 4.6 0.42 11.0 0.2 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC44936.1 - 0.026 14.8 0.2 0.72 10.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Rhodanese_C PF12368.8 EFC44936.1 - 0.049 14.0 5.1 0.15 12.5 5.1 1.8 1 0 0 1 1 1 0 Rhodanase C-terminal Fis1_TPR_C PF14853.6 EFC44936.1 - 0.15 12.1 0.0 0.15 12.1 0.0 3.1 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat HEPN_Apea PF18739.1 EFC44936.1 - 1.8 9.1 6.4 12 6.4 0.1 4.2 3 1 0 3 3 3 0 Apea-like HEPN zf-Mss51 PF13824.6 EFC44936.1 - 2.6 8.2 8.9 7.7 6.7 8.9 1.8 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C6H2 PF15801.5 EFC44936.1 - 8.4 6.8 12.6 20 5.6 12.6 1.7 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Abhydrolase_1 PF00561.20 EFC44938.1 - 8e-12 45.3 0.0 4.4e-09 36.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 EFC44938.1 - 1.5e-11 43.7 0.0 3.3e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 EFC44938.1 - 9.7e-08 31.6 0.0 0.00015 21.2 0.0 2.4 2 1 0 2 2 2 2 Serine aminopeptidase, S33 GTP_EFTU PF00009.27 EFC44939.1 - 2.6e-61 206.6 0.2 4.6e-61 205.8 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFC44939.1 - 7.6e-32 109.6 0.1 2.9e-31 107.8 0.1 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 EFC44939.1 - 5.5e-29 100.1 0.0 1.1e-28 99.1 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFC44939.1 - 1.6e-24 85.7 0.1 4.1e-24 84.4 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFC44939.1 - 7.7e-12 45.4 0.1 2e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 EFC44939.1 - 1.1e-06 28.5 0.0 2.2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 EFC44939.1 - 0.00082 19.4 0.0 0.0021 18.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 EFC44939.1 - 0.0087 15.4 0.1 0.029 13.7 0.0 1.8 2 0 0 2 2 2 1 AIG1 family EGF_2 PF07974.13 EFC44940.1 - 2.6e-16 59.7 140.7 0.0007 19.9 9.5 10.6 11 0 0 11 11 11 7 EGF-like domain Jacalin PF01419.17 EFC44940.1 - 2.1e-06 27.7 2.3 8.4e-06 25.8 2.0 2.2 1 1 1 2 2 2 1 Jacalin-like lectin domain EGF PF00008.27 EFC44940.1 - 0.01 16.1 3.6 0.01 16.1 3.6 9.5 8 1 0 8 8 8 0 EGF-like domain AAA_lid_10 PF17872.1 EFC44942.1 - 2.3 8.4 4.8 2.7 8.1 0.9 2.4 2 0 0 2 2 2 0 AAA lid domain Insulin_TMD PF17870.1 EFC44942.1 - 5.3 7.2 6.3 19 5.4 6.3 2.0 1 1 0 1 1 1 0 Insulin receptor trans-membrane segment RRM_1 PF00076.22 EFC44943.1 - 5.2e-21 74.2 0.0 1.1e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 EFC44943.1 - 1.7e-20 73.4 3.2 3.3e-20 72.5 3.2 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF5521 PF17659.1 EFC44944.1 - 1.1e-15 56.6 1.7 2.4e-15 55.5 1.7 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5521) DUF5088 PF17008.5 EFC44944.1 - 1.7e-10 40.9 5.1 4e-09 36.5 1.7 3.3 2 1 0 2 2 2 1 Domain of unknown function (DUF5088) CDC24_OB3 PF17244.2 EFC44944.1 - 9.2e-05 22.3 0.7 0.01 15.6 0.3 2.8 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 tRNA_anti_2 PF13742.6 EFC44944.1 - 0.0083 16.3 0.1 0.77 10.0 0.0 3.2 2 1 0 2 2 2 1 OB-fold nucleic acid binding domain Rep-A_N PF04057.12 EFC44944.1 - 0.015 15.3 0.7 0.054 13.5 0.7 2.0 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain GDPD PF03009.17 EFC44945.1 - 5.5e-36 124.6 0.0 6.7e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family MadM PF03818.13 EFC44945.1 - 0.026 14.4 1.2 0.055 13.4 1.2 1.6 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit Cadherin_C_2 PF16492.5 EFC44945.1 - 0.043 14.6 0.7 0.15 12.8 0.9 1.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal ECSCR PF15820.5 EFC44945.1 - 0.085 12.7 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator UL41A PF17591.2 EFC44945.1 - 0.091 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL41A EpsG PF14897.6 EFC44946.1 - 0.0073 15.6 7.4 0.0097 15.2 7.4 1.1 1 0 0 1 1 1 1 EpsG family DHHC PF01529.20 EFC44946.1 - 0.01 15.9 11.1 0.1 12.7 0.8 2.6 1 1 1 3 3 3 0 DHHC palmitoyltransferase TMEM192 PF14802.6 EFC44946.1 - 0.67 9.0 6.5 3.7 6.6 0.6 2.6 2 1 0 2 2 2 0 TMEM192 family Oxidored_q4 PF00507.19 EFC44946.1 - 3.6 7.8 10.0 2.1 8.6 1.0 2.6 3 0 0 3 3 3 0 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 zf-LITAF-like PF10601.9 EFC44946.1 - 9.9 6.5 9.3 26 5.2 1.9 3.2 2 1 1 3 3 3 0 LITAF-like zinc ribbon domain Polbeta PF18765.1 EFC44947.1 - 0.0003 20.8 1.5 0.0044 17.1 0.6 2.8 2 1 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase TFIID_NTD2 PF04494.15 EFC44947.1 - 0.018 15.3 1.1 0.034 14.4 1.1 1.5 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain PPR PF01535.20 EFC44948.1 - 5.9e-11 41.8 5.5 9.2 6.8 0.0 8.9 9 0 0 9 9 9 4 PPR repeat PPR_2 PF13041.6 EFC44948.1 - 6.1e-11 42.3 7.0 0.0017 18.5 0.1 8.9 7 2 3 10 10 10 2 PPR repeat family PPR_3 PF13812.6 EFC44948.1 - 1.5e-05 25.0 10.4 0.00025 21.1 0.1 4.6 6 0 0 6 6 6 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC44948.1 - 0.0027 17.1 1.6 0.011 15.1 0.8 2.4 3 1 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP DsrC PF04358.13 EFC44948.1 - 0.015 15.8 1.2 0.066 13.7 0.1 2.7 2 1 1 3 3 3 0 DsrC like protein PTR PF12789.7 EFC44948.1 - 0.022 14.8 0.2 0.072 13.2 0.2 1.8 1 0 0 1 1 1 0 Phage tail repeat like DUF4983 PF16356.5 EFC44948.1 - 0.043 14.6 0.6 1.3 9.9 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4983) Kinesin PF00225.23 EFC44949.1 - 9.7e-67 225.2 4.7 9.7e-67 225.2 4.7 2.7 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC44949.1 - 1.7e-18 67.0 6.2 5.1e-18 65.4 0.0 3.2 2 1 0 2 2 2 1 Microtubule binding cIII PF08134.11 EFC44949.1 - 0.0053 16.5 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 cIII protein family AAA_7 PF12775.7 EFC44949.1 - 0.052 13.1 6.9 5.5 6.5 0.0 3.4 3 0 0 3 3 3 0 P-loop containing dynein motor region CSTF2_hinge PF14327.6 EFC44949.1 - 1.3 9.5 6.6 0.65 10.5 0.9 2.7 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 CHAD PF05235.14 EFC44949.1 - 9.1 6.2 12.9 79 3.1 12.9 2.1 1 1 0 1 1 1 0 CHAD domain Spc7 PF08317.11 EFC44949.1 - 9.8 5.0 47.7 0.57 9.0 14.7 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein RGS PF00615.19 EFC44950.1 - 1.8e-07 31.5 0.9 1.8e-07 31.5 0.9 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF3021 PF11457.8 EFC44950.1 - 0.31 11.4 17.3 0.27 11.6 0.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3021) DUF2207 PF09972.9 EFC44951.1 - 0.22 10.3 8.1 0.32 9.7 6.7 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4149 PF13664.6 EFC44951.1 - 0.26 11.6 6.1 0.96 9.8 2.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4149) DUF2417 PF10329.9 EFC44951.1 - 2.8 7.3 8.3 19 4.6 6.8 2.2 2 0 0 2 2 2 0 Region of unknown function (DUF2417) Histone PF00125.24 EFC44952.1 - 4e-19 69.3 4.3 4e-19 69.3 4.3 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFC44952.1 - 9.1e-07 29.1 0.1 2.9e-06 27.5 0.1 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone GMP_synt_C PF00958.22 EFC44952.1 - 0.0035 17.4 0.1 0.0054 16.8 0.1 1.3 1 0 0 1 1 1 1 GMP synthase C terminal domain DUF3915 PF13054.6 EFC44952.1 - 2 8.4 5.6 0.42 10.6 0.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3915) FAM176 PF14851.6 EFC44952.1 - 6.2 6.5 9.3 0.47 10.1 1.7 2.2 2 0 0 2 2 2 0 FAM176 family Folate_carrier PF01770.18 EFC44952.1 - 7.9 5.1 11.0 0.071 11.8 1.2 1.9 1 1 1 2 2 2 0 Reduced folate carrier RasGEF PF00617.19 EFC44953.1 - 5.2e-13 49.6 2.3 1e-12 48.6 1.8 1.8 1 1 0 1 1 1 1 RasGEF domain MIF4G_like PF09088.11 EFC44953.1 - 0.0056 16.5 0.5 0.037 13.8 0.0 2.3 2 0 0 2 2 2 1 MIF4G like F-box-like PF12937.7 EFC44953.1 - 0.098 12.6 0.0 0.34 10.9 0.0 2.0 2 0 0 2 2 2 0 F-box-like TTL PF03133.15 EFC44955.1 - 6e-97 324.3 4.7 7.7e-97 324.0 4.7 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFC44955.1 - 9.1e-08 31.7 1.1 0.00027 20.3 0.0 3.0 3 1 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFC44955.1 - 3.1e-05 23.4 0.0 0.0097 15.2 0.0 2.4 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp DUF755 PF05501.11 EFC44955.1 - 0.042 14.1 2.9 0.11 12.8 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF755) RimK PF08443.11 EFC44955.1 - 0.14 11.7 0.0 0.79 9.3 0.0 2.0 2 0 0 2 2 2 0 RimK-like ATP-grasp domain DUF3446 PF11928.8 EFC44959.1 - 0.17 12.2 11.0 0.35 11.2 11.0 1.4 1 0 0 1 1 1 0 Early growth response N-terminal domain DTHCT PF08070.11 EFC44959.1 - 4.7 8.0 17.9 11 6.8 3.7 2.5 2 1 0 2 2 2 0 DTHCT (NUC029) region MutS_V PF00488.21 EFC44960.1 - 8.3e-74 247.7 2.4 1.4e-73 247.0 2.4 1.3 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 EFC44960.1 - 3.7e-41 139.9 0.0 1.1e-40 138.4 0.0 1.9 1 0 0 1 1 1 1 MutS domain I MutS_III PF05192.18 EFC44960.1 - 1.1e-32 113.9 3.2 1.1e-32 113.9 3.2 2.0 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EFC44960.1 - 1.8e-21 76.3 1.6 6e-21 74.6 1.6 2.0 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EFC44960.1 - 6e-10 39.5 0.3 5.5e-09 36.4 0.0 2.7 2 1 0 2 2 2 1 MutS domain II AAA_14 PF13173.6 EFC44960.1 - 0.096 12.7 0.7 1 9.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 EFC44960.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFC44960.1 - 7 7.1 13.1 8.4 6.8 0.0 3.3 2 1 0 2 2 2 0 AAA domain FH2 PF02181.23 EFC44961.1 - 2.8e-88 296.5 8.1 2.8e-88 296.5 8.1 3.1 4 1 0 4 4 4 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 EFC44961.1 - 4.9e-21 75.2 7.9 4.9e-21 75.2 7.9 3.1 3 0 0 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 EFC44961.1 - 1.5e-20 73.6 14.2 1.2e-11 44.5 0.4 3.8 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain F-box-like PF12937.7 EFC44961.1 - 4.2e-05 23.3 0.0 8.9e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC44961.1 - 0.0027 17.5 0.1 0.0064 16.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain Phage_RpbA PF10789.9 EFC44961.1 - 0.003 17.6 1.9 0.01 15.9 0.2 2.5 2 0 0 2 2 2 1 Phage RNA polymerase binding, RpbA DUF1963 PF09234.10 EFC44961.1 - 7.3 7.0 10.1 1.3 9.4 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1963) NPV_P10 PF05531.12 EFC44961.1 - 8.7 6.9 10.3 57 4.3 0.2 4.9 3 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein UQ_con PF00179.26 EFC44962.1 - 2.3e-49 166.7 0.1 2.5e-49 166.5 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC44962.1 - 8.3e-05 22.3 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 EFC44962.1 - 0.0021 18.3 0.1 0.0026 18.0 0.1 1.4 1 1 0 1 1 1 1 RWD domain XG_FTase PF03254.13 EFC44963.1 - 4.5e-11 42.1 3.6 0.00025 19.8 0.0 2.8 2 1 0 2 2 2 2 Xyloglucan fucosyltransferase Aldo_ket_red PF00248.21 EFC44964.1 - 2.1e-50 171.6 0.2 1.4e-36 126.2 0.1 2.1 2 0 0 2 2 2 2 Aldo/keto reductase family Endopep_inhib PF16800.5 EFC44964.1 - 0.0068 16.4 0.1 0.016 15.2 0.1 1.6 1 0 0 1 1 1 1 IseA DL-endopeptidase inhibitor PPR_2 PF13041.6 EFC44965.1 - 3.1e-11 43.3 1.5 6.8e-07 29.4 0.0 2.7 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.6 EFC44965.1 - 1.5e-07 31.4 7.5 0.00011 22.2 0.7 3.0 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC44965.1 - 0.09 12.5 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 PPR repeat Peptidase_M28 PF04389.17 EFC44966.1 - 1.4e-33 116.3 0.0 2.1e-33 115.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 EFC44966.1 - 0.004 16.9 0.0 0.0061 16.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PIN_11 PF18479.1 EFC44967.1 - 0.022 14.9 0.4 0.067 13.4 0.4 1.9 1 1 0 1 1 1 0 PIN like domain RGS PF00615.19 EFC44968.1 - 2e-05 24.9 1.3 4.5e-05 23.7 0.1 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain SAM_2 PF07647.17 EFC44969.1 - 9e-07 28.9 1.1 7.2e-05 22.8 1.1 2.5 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC44969.1 - 1.6e-06 28.4 0.9 0.0016 18.8 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) WD40 PF00400.32 EFC44970.1 - 3.9e-48 160.4 26.4 2.8e-10 40.6 0.2 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC44970.1 - 9.1e-26 90.0 3.5 5.1e-06 26.7 0.0 6.5 4 3 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC44970.1 - 6.4e-12 45.7 0.3 0.00036 20.5 0.1 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 EFC44970.1 - 7e-10 38.5 0.2 1.5e-09 37.4 0.2 1.6 1 0 0 1 1 1 1 LisH WD40_like PF17005.5 EFC44970.1 - 0.00016 21.1 0.0 0.12 11.6 0.0 2.7 2 1 1 3 3 3 3 WD40-like domain Proteasome_A_N PF10584.9 EFC44970.1 - 0.00057 19.5 0.1 2.6 7.8 0.0 4.4 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Coatomer_WDAD PF04053.14 EFC44970.1 - 0.001 18.2 0.2 4 6.4 0.0 3.6 3 1 1 4 4 4 2 Coatomer WD associated region PD40 PF07676.12 EFC44970.1 - 0.0016 18.3 7.8 1.3 9.0 0.0 4.8 5 1 0 5 5 4 2 WD40-like Beta Propeller Repeat SOG2 PF10428.9 EFC44970.1 - 0.0045 16.3 16.0 0.0062 15.8 16.0 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein Ge1_WD40 PF16529.5 EFC44970.1 - 0.0065 15.5 1.1 5.7 5.8 0.0 3.6 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 EFC44970.1 - 0.017 14.5 0.1 0.77 9.0 0.0 3.0 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal SRP-alpha_N PF04086.13 EFC44970.1 - 0.16 11.8 11.0 0.32 10.9 11.0 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Macoilin PF09726.9 EFC44970.1 - 0.74 8.3 12.7 1 7.8 12.7 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 EFC44970.1 - 1.6 5.7 9.4 2.2 5.3 9.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 EFC44970.1 - 2.2 8.3 5.5 3.3 7.7 5.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Dicty_REP PF05086.12 EFC44970.1 - 3.9 5.3 15.3 5.7 4.8 15.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Apt1 PF10351.9 EFC44970.1 - 5.4 5.7 12.4 8.3 5.1 12.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Methyltransf_18 PF12847.7 EFC44971.1 - 0.015 15.2 0.1 0.04 13.8 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFC44971.1 - 0.07 13.9 0.2 0.27 12.0 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Spectrin PF00435.21 EFC44972.1 - 1.6 9.3 13.3 0.19 12.3 0.7 3.3 4 0 0 4 4 4 0 Spectrin repeat Epimerase PF01370.21 EFC44973.1 - 2.1e-18 66.7 0.0 3.2e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC44973.1 - 3.9e-17 62.2 0.0 5.7e-17 61.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC44973.1 - 9.9e-13 48.2 0.0 1.3e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFC44973.1 - 2e-10 40.3 0.0 3.3e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 EFC44973.1 - 6.6e-10 39.2 0.0 2.1e-09 37.5 0.0 1.9 2 1 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 EFC44973.1 - 1.9e-05 24.6 0.0 3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC44973.1 - 5.4e-05 22.5 0.0 8e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein MFS_1 PF07690.16 EFC44974.1 - 6.5e-25 87.8 37.7 3.4e-23 82.1 16.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Zip PF02535.22 EFC44974.1 - 8.3e-05 22.0 0.9 0.0003 20.1 0.0 2.3 2 1 1 3 3 3 1 ZIP Zinc transporter Connexin PF00029.19 EFC44974.1 - 0.13 12.0 0.3 15 5.2 0.1 2.3 2 0 0 2 2 2 0 Connexin CobT PF06213.12 EFC44974.1 - 1.2 8.5 8.8 2.4 7.5 8.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FH2 PF02181.23 EFC44975.1 - 1.9e-81 274.1 0.6 1.9e-81 274.1 0.6 4.3 3 1 1 4 4 4 1 Formin Homology 2 Domain Drf_GBD PF06371.13 EFC44975.1 - 3.6e-16 59.3 1.3 3.6e-16 59.3 1.3 4.8 4 1 1 5 5 5 1 Diaphanous GTPase-binding Domain DUF3361 PF11841.8 EFC44975.1 - 0.00068 19.6 6.3 0.0019 18.1 0.5 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3361) MSA-2c PF12238.8 EFC44975.1 - 0.015 15.3 0.6 0.015 15.3 0.6 3.3 3 0 0 3 3 3 0 Merozoite surface antigen 2c FERM_M PF00373.18 EFC44977.1 - 3.5e-05 24.2 0.5 3.5e-05 24.2 0.5 2.7 2 1 0 3 3 3 1 FERM central domain Lon_C PF05362.13 EFC44978.1 - 6.3e-69 231.6 0.1 5.8e-58 195.8 0.0 2.6 1 1 0 2 2 2 2 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 EFC44978.1 - 6.4e-29 101.3 2.0 6.4e-29 101.3 2.0 2.8 3 0 0 3 3 3 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 EFC44978.1 - 1.5e-23 83.7 2.6 6.6e-23 81.6 0.0 3.2 3 1 1 4 4 4 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 EFC44978.1 - 7.4e-07 29.0 0.1 5.4e-06 26.3 0.0 2.4 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 EFC44978.1 - 1.1e-06 28.7 0.0 3.3e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFC44978.1 - 1.7e-06 27.9 0.1 1.5e-05 24.8 0.1 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 EFC44978.1 - 5.8e-06 25.5 0.0 1.5e-05 24.1 0.0 1.7 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 EFC44978.1 - 0.0001 22.6 1.8 0.011 16.1 0.2 3.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC44978.1 - 0.0022 18.4 7.0 0.0041 17.5 0.1 3.9 4 2 2 6 6 4 1 AAA ATPase domain AAA_18 PF13238.6 EFC44978.1 - 0.0026 18.3 0.0 0.0026 18.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_3 PF07726.11 EFC44978.1 - 0.0033 17.3 0.0 0.012 15.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFC44978.1 - 0.0039 17.1 0.1 0.018 15.0 0.1 2.1 1 0 0 1 1 1 1 RsgA GTPase IstB_IS21 PF01695.17 EFC44978.1 - 0.0053 16.5 0.1 0.017 14.9 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein NUC153 PF08159.12 EFC44978.1 - 0.011 15.5 2.3 0.015 15.1 0.6 2.1 2 0 0 2 2 2 0 NUC153 domain TIP49 PF06068.13 EFC44978.1 - 0.012 14.8 0.1 0.012 14.8 0.1 3.0 4 0 0 4 4 3 0 TIP49 P-loop domain Ureide_permease PF07168.11 EFC44978.1 - 0.013 14.3 0.7 0.026 13.3 0.7 1.5 1 0 0 1 1 1 0 Ureide permease RNA_helicase PF00910.22 EFC44978.1 - 0.02 15.3 0.1 0.082 13.3 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_14 PF13173.6 EFC44978.1 - 0.041 13.9 0.0 0.041 13.9 0.0 2.6 3 0 0 3 3 1 0 AAA domain Folate_carrier PF01770.18 EFC44978.1 - 0.09 11.5 2.4 0.15 10.8 2.4 1.3 1 0 0 1 1 1 0 Reduced folate carrier AAA_19 PF13245.6 EFC44978.1 - 0.12 12.6 1.4 0.8 10.0 0.2 2.8 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 EFC44978.1 - 0.14 11.6 2.3 0.33 10.5 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region SKI PF01202.22 EFC44978.1 - 0.27 11.3 0.1 0.27 11.3 0.1 3.2 4 0 0 4 4 2 0 Shikimate kinase Tet_JBP PF12851.7 EFC44978.1 - 2.5 7.3 6.9 0.39 10.0 0.9 2.1 1 1 0 2 2 2 0 Oxygenase domain of the 2OGFeDO superfamily DUF1493 PF07377.12 EFC44978.1 - 2.6 8.5 6.6 5.7 7.4 1.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1493) adh_short PF00106.25 EFC44979.1 - 1.1e-16 60.8 0.0 5e-15 55.5 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC44979.1 - 1.3e-13 51.0 0.0 2.3e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC44979.1 - 0.00041 20.3 0.1 0.00098 19.1 0.1 1.6 2 0 0 2 2 2 1 KR domain Na_Ca_ex PF01699.24 EFC44980.1 - 3.3e-40 137.5 50.0 1.6e-22 80.0 17.2 3.3 3 0 0 3 3 3 2 Sodium/calcium exchanger protein ArfGap PF01412.18 EFC44980.1 - 4.8e-35 120.1 1.7 9.2e-35 119.2 1.7 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf C2 PF00168.30 EFC44980.1 - 2e-16 60.2 0.2 7e-16 58.4 0.1 2.0 2 0 0 2 2 2 1 C2 domain Vpu PF00558.19 EFC44980.1 - 0.086 12.6 0.9 1.2 8.9 0.2 3.0 2 0 0 2 2 2 0 Vpu protein PrcB_C PF14343.6 EFC44981.1 - 6.5e-12 45.4 0.1 1.2e-11 44.5 0.1 1.5 1 0 0 1 1 1 1 PrcB C-terminal Peptidase_C92 PF05708.12 EFC44983.1 - 2.5e-08 34.2 0.2 0.0046 17.1 0.0 2.4 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family GCP_N_terminal PF17681.1 EFC44984.1 - 1.9e-61 208.4 2.0 1.9e-61 208.4 2.0 2.7 2 1 0 3 3 3 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFC44984.1 - 1.7e-58 198.5 13.1 1.7e-58 198.5 13.1 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Guanylate_kin PF00625.21 EFC44985.1 - 1.2e-19 70.7 0.7 1.3e-19 70.6 0.7 1.0 1 0 0 1 1 1 1 Guanylate kinase DUF1699 PF08004.11 EFC44985.1 - 0.00078 19.1 0.0 0.00097 18.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1699) PAP_central PF04928.17 EFC44986.1 - 1.2e-99 332.3 0.1 2.2e-99 331.5 0.0 1.4 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 EFC44986.1 - 1.2e-19 70.5 4.9 8.2e-13 48.3 0.1 2.9 1 1 2 3 3 3 2 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 EFC44986.1 - 2.8e-09 37.1 0.1 1.1e-08 35.2 0.0 2.1 2 0 0 2 2 2 1 Nucleotidyltransferase domain Presenilin PF01080.17 EFC44986.1 - 9.7 4.8 6.7 16 4.1 6.7 1.3 1 0 0 1 1 1 0 Presenilin ATP12 PF07542.11 EFC44987.1 - 4e-23 81.9 0.0 6.9e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 ATP12 chaperone protein DUF2130 PF09903.9 EFC44987.1 - 0.036 13.3 0.5 0.077 12.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2130) Amj PF10997.8 EFC44987.1 - 0.089 12.1 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Alternate to MurJ DUF3372 PF11852.8 EFC44987.1 - 0.11 12.0 0.1 0.3 10.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) Rad52_Rad22 PF04098.15 EFC44988.1 - 2.4e-08 34.0 0.0 2.9e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ribosomal_S5 PF00333.20 EFC44988.1 - 0.17 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain Mo25 PF08569.11 EFC44989.1 - 1.2e-114 383.1 17.9 1.5e-114 382.7 17.9 1.0 1 0 0 1 1 1 1 Mo25-like SDH_C PF18317.1 EFC44989.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate 5'-dehydrogenase C-terminal domain Glyco_transf_24 PF18404.1 EFC44990.1 - 4.3e-132 439.5 6.8 9.7e-132 438.3 6.8 1.6 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 EFC44990.1 - 5e-32 111.9 10.9 1.6e-30 106.9 1.1 3.8 2 2 1 3 3 3 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 EFC44990.1 - 8.8e-22 77.5 1.3 8.8e-22 77.5 1.3 2.6 3 0 0 3 3 3 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 EFC44990.1 - 5.3e-19 68.3 0.0 2e-18 66.5 0.0 2.1 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Glyco_transf_8 PF01501.20 EFC44990.1 - 4.1e-06 26.6 0.4 1.3e-05 24.9 0.4 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 8 Thioredoxin_15 PF18403.1 EFC44990.1 - 0.00018 21.5 0.0 0.18 11.7 0.0 3.7 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 EFC44990.1 - 0.066 13.0 0.5 0.35 10.7 0.1 2.3 2 1 1 3 3 3 0 Thioredoxin-like domain Methyltransf_11 PF08241.12 EFC44991.1 - 1.6e-06 28.7 0.0 3.1e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC44991.1 - 4.7e-06 27.2 0.0 1e-05 26.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC44991.1 - 9.8e-05 22.2 0.1 0.00014 21.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Guanylate_kin PF00625.21 EFC44991.1 - 0.041 13.6 0.3 0.084 12.6 0.3 1.7 1 1 0 1 1 1 0 Guanylate kinase FA_desaturase PF00487.24 EFC44992.1 - 3.1e-19 69.8 38.1 1.1e-12 48.4 21.2 3.0 2 1 1 3 3 3 2 Fatty acid desaturase Cyt-b5 PF00173.28 EFC44992.1 - 5.3e-14 52.1 0.0 1.2e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NUC PF18510.1 EFC44992.1 - 0.01 16.3 0.1 0.029 14.8 0.1 1.7 1 0 0 1 1 1 0 Nuclease domain SPC25 PF06703.11 EFC44992.1 - 9.7 6.0 10.0 0.41 10.4 2.4 2.6 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF1350 PF07082.11 EFC44993.1 - 0.11 11.7 0.1 0.27 10.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) PepSY_TM_like_2 PF16357.5 EFC44993.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like Pkinase_Tyr PF07714.17 EFC44994.1 - 8.1e-31 107.2 0.0 6.3e-28 97.8 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC44994.1 - 2e-30 106.1 0.2 2.1e-28 99.4 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC44994.1 - 1e-05 24.5 0.2 1.2e-05 24.3 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC44994.1 - 0.029 14.3 0.0 0.041 13.8 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFC44995.1 - 4.1e-26 91.9 0.4 8e-26 91.0 0.4 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC44995.1 - 3.9e-11 42.7 0.1 7.7e-11 41.8 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC44995.1 - 0.0014 17.5 0.0 0.0027 16.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Ninjurin PF04923.12 EFC44996.1 - 0.11 12.5 2.0 0.29 11.1 2.0 1.7 1 0 0 1 1 1 0 Ninjurin HMG_box PF00505.19 EFC44997.1 - 6.8e-22 77.7 17.1 1e-11 45.1 1.8 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC44997.1 - 1.2e-12 48.3 19.1 1.8e-07 31.6 8.3 2.5 2 0 0 2 2 2 2 HMG-box domain Ccdc124 PF06244.12 EFC44997.1 - 0.036 14.6 1.0 0.036 14.6 1.0 3.9 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 124 /Oxs1 DinI PF06183.13 EFC44997.1 - 0.16 12.4 3.2 5.6 7.4 0.4 2.7 2 0 0 2 2 2 0 DinI-like family GET2 PF08690.10 EFC44997.1 - 4 7.0 28.1 4 7.0 26.5 1.7 1 1 1 2 2 2 0 GET complex subunit GET2 F-box PF00646.33 EFC44998.1 - 0.0012 18.7 0.0 0.0037 17.1 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC44998.1 - 0.0052 16.6 0.2 0.0097 15.8 0.2 1.4 1 0 0 1 1 1 1 F-box-like PRANC PF09372.10 EFC44998.1 - 0.038 14.3 0.7 0.18 12.1 0.5 2.1 2 0 0 2 2 2 0 PRANC domain Elicitin PF00964.17 EFC44998.1 - 0.041 14.0 0.1 0.075 13.1 0.1 1.4 1 0 0 1 1 1 0 Elicitin GyrB_insert PF18053.1 EFC44999.1 - 0.0043 17.0 0.2 0.017 15.0 0.2 2.0 1 0 0 1 1 1 1 DNA gyrase B subunit insert domain TPR_1 PF00515.28 EFC45000.1 - 3.7e-34 115.1 17.1 3.4e-07 29.8 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC45000.1 - 4.1e-28 95.2 16.2 2.9e-05 23.9 0.0 7.7 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFC45000.1 - 1.8e-24 83.9 20.3 6.7e-06 25.9 0.0 7.7 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 EFC45000.1 - 1.2e-17 63.9 14.6 9.8e-07 29.0 1.0 6.2 4 2 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC45000.1 - 2.8e-17 61.9 3.7 0.00058 20.5 0.0 5.7 3 3 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 EFC45000.1 - 3.5e-15 54.8 7.1 0.0034 17.3 0.6 5.5 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFC45000.1 - 6.6e-15 54.5 8.1 8e-07 28.6 0.1 5.7 4 2 2 6 6 6 3 TPR repeat TPR_19 PF14559.6 EFC45000.1 - 1.4e-13 51.2 4.3 0.0011 19.5 0.0 5.1 3 1 3 6 6 5 5 Tetratricopeptide repeat ANAPC8 PF04049.13 EFC45000.1 - 1e-12 48.3 2.4 1e-12 48.3 2.4 2.7 2 1 1 3 3 3 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_16 PF13432.6 EFC45000.1 - 3.6e-10 40.3 4.3 0.002 18.8 0.1 4.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC45000.1 - 1.5e-08 34.3 6.9 0.18 11.7 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC45000.1 - 1.8e-08 34.5 20.8 0.87 10.4 0.0 8.0 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC45000.1 - 1.8e-08 34.2 14.2 0.37 11.3 0.1 7.5 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_15 PF13429.6 EFC45000.1 - 1.4e-07 31.1 14.4 0.0034 16.6 0.3 4.5 2 2 3 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45000.1 - 2e-07 31.1 21.0 0.077 13.2 0.5 5.0 3 2 0 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFC45000.1 - 5.3e-07 29.7 0.2 0.23 11.7 0.0 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat BTAD PF03704.17 EFC45000.1 - 1.3e-06 28.9 1.3 0.097 13.1 0.3 3.3 3 0 0 3 3 3 2 Bacterial transcriptional activator domain ChAPs PF09295.10 EFC45000.1 - 5.8e-05 22.3 3.6 0.075 12.0 0.1 3.7 2 1 2 4 4 4 3 ChAPs (Chs5p-Arf1p-binding proteins) DUF3856 PF12968.7 EFC45000.1 - 0.0022 18.1 0.3 0.012 15.7 0.1 2.3 1 1 1 2 2 2 1 Domain of Unknown Function (DUF3856) PPR PF01535.20 EFC45000.1 - 0.012 15.8 1.0 2.7 8.4 0.1 3.9 4 0 0 4 4 4 0 PPR repeat Sel1 PF08238.12 EFC45000.1 - 0.05 14.3 3.5 15 6.5 0.0 4.6 5 0 0 5 5 4 0 Sel1 repeat TAF8_C PF10406.9 EFC45001.1 - 6.2e-15 55.5 3.0 6.2e-15 55.5 3.0 2.5 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 EFC45001.1 - 3.8e-12 46.0 0.0 7.8e-12 45.0 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated CENP-S PF15630.6 EFC45001.1 - 0.016 15.6 0.4 7.5 7.0 0.1 2.8 2 0 0 2 2 2 0 CENP-S protein TFIID-31kDa PF02291.15 EFC45001.1 - 0.022 14.8 2.2 0.13 12.3 0.0 2.5 2 1 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Plant_all_beta PF10532.9 EFC45001.1 - 0.068 13.5 4.5 0.31 11.3 4.5 2.2 1 0 0 1 1 1 0 Plant specific N-all beta domain TFIID_20kDa PF03847.13 EFC45001.1 - 0.09 13.3 2.3 1 9.9 0.2 3.0 3 0 0 3 3 3 0 Transcription initiation factor TFIID subunit A DUF3323 PF11796.8 EFC45001.1 - 0.14 12.0 0.7 0.23 11.3 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) DUF3398 PF11878.8 EFC45001.1 - 0.61 10.5 6.2 0.69 10.4 3.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3398) WD40 PF00400.32 EFC45002.1 - 4.9e-27 93.6 10.9 4.3e-06 27.4 0.1 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC45002.1 - 1.9e-06 28.0 0.0 0.017 15.4 0.0 4.0 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC45002.1 - 0.0013 18.1 0.0 1.4 8.1 0.0 2.5 2 0 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 EFC45002.1 - 0.025 13.6 0.3 0.056 12.4 0.3 1.6 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TPR_8 PF13181.6 EFC45003.1 - 1.5e-22 77.8 7.0 0.00072 19.6 0.1 10.0 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC45003.1 - 7.7e-22 75.6 6.4 0.012 15.6 0.5 10.6 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45003.1 - 9.9e-20 70.8 1.2 0.00036 21.0 0.0 7.3 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 EFC45003.1 - 6.4e-16 57.4 8.7 0.00022 20.9 0.0 7.9 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC45003.1 - 6.5e-15 54.6 0.0 0.05 14.5 0.0 9.1 6 3 3 9 9 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC45003.1 - 7.6e-15 53.8 1.1 0.0054 16.7 0.0 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC45003.1 - 1.4e-13 50.2 0.2 0.045 14.1 0.0 9.2 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC45003.1 - 1.6e-13 50.8 2.5 0.00043 20.5 0.9 6.3 7 1 0 7 7 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC45003.1 - 1.2e-10 41.8 0.0 0.11 13.2 0.0 6.2 6 1 1 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45003.1 - 1e-09 38.5 9.5 0.007 16.6 0.1 5.9 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFC45003.1 - 2.6e-09 37.1 0.5 9.8 7.1 0.0 8.7 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC45003.1 - 7.6e-09 35.1 3.8 0.93 9.2 0.0 6.4 7 0 0 7 7 5 3 TPR repeat TPR_9 PF13371.6 EFC45003.1 - 5.1e-06 26.5 0.1 0.8 9.9 0.0 5.0 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 EFC45003.1 - 6.5e-05 23.2 0.3 2.2 8.6 0.0 5.2 5 1 0 5 5 5 1 Tetratricopeptide repeat NARP1 PF12569.8 EFC45003.1 - 6.7e-05 22.0 7.4 0.0029 16.6 0.2 4.7 4 1 1 5 5 5 1 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 EFC45003.1 - 0.00047 19.9 1.9 4.1 7.4 0.1 5.2 7 0 0 7 7 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC45003.1 - 0.015 15.3 3.1 0.67 10.1 0.0 3.9 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ALC PF17527.2 EFC45003.1 - 0.018 14.7 0.3 0.079 12.6 0.3 2.1 1 0 0 1 1 1 0 Phage ALC protein TPR_15 PF13429.6 EFC45003.1 - 0.053 12.7 0.0 2.7 7.1 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat CDC45 PF02724.14 EFC45003.1 - 0.79 7.9 17.4 0.21 9.9 5.4 2.2 2 0 0 2 2 2 0 CDC45-like protein zf-RING_2 PF13639.6 EFC45004.1 - 7.1e-07 29.5 9.1 1.5e-06 28.4 9.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 EFC45004.1 - 4.9e-05 23.3 3.8 0.00012 22.1 3.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 EFC45004.1 - 0.00012 22.3 7.7 0.00033 20.9 7.7 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain FANCL_C PF11793.8 EFC45004.1 - 0.0012 18.9 4.2 0.0035 17.5 4.2 1.8 1 0 0 1 1 1 1 FANCL C-terminal domain TINF2_N PF14973.6 EFC45004.1 - 0.031 14.6 7.6 1.9 8.8 0.2 4.2 3 1 0 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus zf-C3HC4 PF00097.25 EFC45004.1 - 0.036 13.9 8.7 0.097 12.6 8.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 EFC45004.1 - 0.069 13.3 7.4 0.16 12.1 7.4 1.7 1 0 0 1 1 1 0 RING-variant domain EF-hand_2 PF09068.11 EFC45004.1 - 0.07 13.3 2.8 0.16 12.1 0.7 2.8 2 0 0 2 2 1 0 EF hand MurB_C PF02873.16 EFC45004.1 - 0.13 12.3 0.0 0.96 9.5 0.0 2.3 2 0 0 2 2 2 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain RTP1_C1 PF10363.9 EFC45004.1 - 0.23 11.7 2.5 2.7 8.2 0.0 3.4 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 SMYLE_N PF18615.1 EFC45004.1 - 0.45 10.0 3.5 0.92 9.0 0.5 2.4 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PHD PF00628.29 EFC45004.1 - 0.9 9.5 6.8 2.2 8.2 6.8 1.7 1 0 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 EFC45004.1 - 1.1 9.6 8.4 2.9 8.3 8.4 1.8 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 EFC45004.1 - 1.2 9.3 3.5 3.3 7.9 3.5 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_2 PF13923.6 EFC45004.1 - 1.3 9.0 8.0 3.7 7.5 8.0 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EFC45004.1 - 1.6 8.4 5.9 3.6 7.3 5.9 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 EFC45004.1 - 1.8 8.5 6.0 4.4 7.2 6.0 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EFC45004.1 - 2.2 8.1 6.3 5.5 6.9 6.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RNA_polI_A14 PF08203.11 EFC45004.1 - 3 8.6 7.1 3.3 8.5 0.9 3.9 3 0 0 3 3 3 0 Yeast RNA polymerase I subunit RPA14 SR-25 PF10500.9 EFC45005.1 - 0.098 12.3 9.1 0.14 11.7 9.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Snf7 PF03357.21 EFC45006.1 - 3.6e-32 111.4 35.5 3.6e-32 111.4 35.5 1.5 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 EFC45006.1 - 0.00045 20.2 12.0 0.00068 19.6 12.0 1.3 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Glyco_hydro_59 PF02057.15 EFC45006.1 - 0.083 12.1 5.0 0.1 11.8 4.6 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 59 DUF3349 PF11829.8 EFC45006.1 - 0.65 10.8 6.9 0.23 12.3 1.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) ACP_PD PF04336.12 EFC45006.1 - 1.4 9.4 11.1 6.5 7.2 2.4 2.6 1 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase OCD_Mu_crystall PF02423.15 EFC45007.1 - 0.0048 15.9 0.1 0.0064 15.5 0.1 1.1 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family PIRT PF15099.6 EFC45007.1 - 0.029 14.0 0.1 0.035 13.7 0.1 1.1 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family DUF3153 PF11353.8 EFC45007.1 - 0.085 12.4 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3153) Gpi16 PF04113.14 EFC45008.1 - 3.9e-59 200.6 0.2 1.4e-31 109.6 0.2 2.0 1 1 1 2 2 2 2 Gpi16 subunit, GPI transamidase component ANAPC4_WD40 PF12894.7 EFC45009.1 - 1.3e-11 44.6 0.7 0.00036 20.8 0.0 5.7 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EFC45009.1 - 8.1e-08 32.2 33.7 0.028 14.3 0.2 7.7 5 2 3 8 8 8 5 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 EFC45009.1 - 3.4e-05 23.1 21.1 0.019 14.0 0.3 6.2 6 1 1 7 7 7 3 Coatomer WD associated region WD40 PF00400.32 EFC45009.1 - 0.00016 22.4 6.1 0.00061 20.6 0.0 4.4 6 0 0 6 6 4 1 WD domain, G-beta repeat eIF2A PF08662.11 EFC45009.1 - 0.00034 20.6 0.9 0.0056 16.6 0.0 3.3 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A WDCP PF15390.6 EFC45009.1 - 0.00046 18.7 0.1 0.0011 17.5 0.1 1.6 1 0 0 1 1 1 1 WD repeat and coiled-coil-containing protein family TPR_14 PF13428.6 EFC45009.1 - 0.0034 18.1 2.8 69 4.7 0.0 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC45009.1 - 0.0037 17.3 12.7 4.9 7.5 0.0 7.5 7 1 1 8 8 8 2 Tetratricopeptide repeat PPR_2 PF13041.6 EFC45009.1 - 0.0054 16.9 3.3 0.16 12.2 0.1 4.2 4 0 0 4 4 4 1 PPR repeat family RPN7 PF10602.9 EFC45009.1 - 0.0096 15.6 6.5 0.16 11.7 0.4 4.8 4 0 0 4 4 4 1 26S proteasome subunit RPN7 TPR_19 PF14559.6 EFC45009.1 - 0.31 11.6 4.6 2.8 8.5 0.1 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Prefoldin_2 PF01920.20 EFC45009.1 - 1.5 8.8 10.0 2.9 7.9 0.4 4.3 4 0 0 4 4 4 0 Prefoldin subunit TPR_12 PF13424.6 EFC45009.1 - 3.9 7.8 16.7 1 9.7 0.4 6.2 7 1 1 8 8 8 0 Tetratricopeptide repeat RNA_pol_Rpb2_6 PF00562.28 EFC45012.1 - 7.1e-123 410.5 0.0 1.1e-122 409.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 EFC45012.1 - 2.3e-50 170.9 0.5 3.4e-50 170.4 0.5 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 EFC45012.1 - 5.2e-34 116.5 0.2 1.2e-33 115.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 EFC45012.1 - 6.9e-25 87.1 0.1 1.8e-24 85.8 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 EFC45012.1 - 4.7e-23 81.8 4.7 1.1e-22 80.7 4.7 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 EFC45012.1 - 7e-19 67.8 0.0 1.3e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 EFC45012.1 - 5.2e-11 42.9 1.8 1.7e-10 41.3 1.8 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF4218 PF13960.6 EFC45012.1 - 0.096 12.3 0.0 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4218) Pkinase_Tyr PF07714.17 EFC45014.1 - 7.3e-49 166.4 4.7 4.6e-48 163.7 0.5 3.0 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 EFC45014.1 - 4.3e-48 164.0 0.2 1e-47 162.7 0.2 1.6 1 0 0 1 1 1 1 Protein kinase domain RCC1 PF00415.18 EFC45014.1 - 1.4e-08 35.2 0.0 1.2e-05 25.9 0.0 3.6 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45014.1 - 6.5e-06 25.8 2.8 0.36 10.7 0.1 4.2 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat APH PF01636.23 EFC45014.1 - 0.021 14.8 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Chlam_PMP PF02415.17 EFC45014.1 - 0.8 10.3 34.2 0.84 10.2 1.6 6.8 7 0 0 7 7 7 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat RGS PF00615.19 EFC45015.1 - 8.2e-06 26.1 0.4 1.8e-05 25.0 0.4 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF1418 PF07214.12 EFC45015.1 - 7.1 6.6 8.1 0.73 9.7 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1418) Exo_endo_phos PF03372.23 EFC45016.1 - 3e-17 62.9 0.0 7e-17 61.7 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Abhydrolase_6 PF12697.7 EFC45017.1 - 5.8e-06 27.1 0.0 7.6e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC45017.1 - 0.0016 17.8 0.0 0.0031 16.8 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 EFC45017.1 - 0.067 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Guanylate_cyc PF00211.20 EFC45018.1 - 0.0015 18.1 0.2 0.0036 17.0 0.2 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain FtsX PF02687.21 EFC45018.1 - 0.015 15.7 0.4 0.68 10.4 0.3 2.5 2 0 0 2 2 2 0 FtsX-like permease family Wzz PF02706.15 EFC45018.1 - 0.16 12.3 3.3 0.48 10.8 0.3 2.9 2 0 0 2 2 2 0 Chain length determinant protein DUF3685 PF12452.8 EFC45018.1 - 0.94 9.2 3.7 2.7 7.6 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3685) Trypan_PARP PF05887.11 EFC45019.1 - 0.014 15.4 3.1 0.038 14.0 3.1 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) zf-C2H2 PF00096.26 EFC45020.1 - 1.9e-08 34.3 10.2 0.0011 19.3 0.4 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 EFC45020.1 - 2.5e-07 31.0 14.4 0.011 16.5 1.0 3.7 3 1 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFC45020.1 - 0.0015 18.7 7.4 1.5 9.2 0.1 3.5 2 1 1 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 EFC45020.1 - 0.018 15.1 0.6 0.018 15.1 0.6 3.6 3 1 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 EFC45020.1 - 0.17 12.3 4.9 19 5.8 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 EFC45020.1 - 1.5 8.5 11.4 7.1 6.3 0.1 3.5 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger MMR_HSR1 PF01926.23 EFC45022.1 - 1.7e-20 73.2 0.0 1.9e-20 73.0 0.0 1.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC45022.1 - 1.9e-06 27.5 0.0 2.1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC45022.1 - 2.4e-06 27.6 0.0 5e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 EFC45022.1 - 2.4e-05 24.5 0.0 0.012 15.7 0.1 2.1 1 1 1 2 2 2 2 Dynamin family Roc PF08477.13 EFC45022.1 - 0.0019 18.4 0.0 0.039 14.2 0.0 2.1 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 EFC45022.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 1 0 1 1 1 0 AIG1 family SRPRB PF09439.10 EFC45022.1 - 0.02 14.3 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFC45022.1 - 0.024 14.2 0.0 2.3 7.7 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain TniB PF05621.11 EFC45022.1 - 0.031 13.7 0.0 0.05 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Septin PF00735.18 EFC45022.1 - 0.052 12.8 0.0 0.38 10.0 0.0 1.9 1 1 0 1 1 1 0 Septin Epimerase PF01370.21 EFC45023.1 - 1.6e-21 76.9 0.0 2.4e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC45023.1 - 2.3e-12 46.5 0.0 3.9e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC45023.1 - 9.7e-12 44.9 0.1 1.5e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFC45023.1 - 5.4e-09 35.5 0.1 8.1e-09 35.0 0.1 1.3 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 EFC45023.1 - 1e-06 28.7 0.0 2.2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 EFC45023.1 - 2.7e-06 27.7 0.0 6.5e-06 26.4 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 EFC45023.1 - 8.3e-06 25.2 0.2 9.2e-05 21.7 0.2 2.3 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 EFC45023.1 - 0.0006 19.4 0.0 0.026 14.1 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 EFC45023.1 - 0.0046 16.9 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 KR domain Remorin_C PF03763.13 EFC45023.1 - 0.027 14.3 0.3 0.07 13.0 0.3 1.7 1 0 0 1 1 1 0 Remorin, C-terminal region Polysacc_synt_2 PF02719.15 EFC45023.1 - 0.028 13.6 0.0 0.046 12.8 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 EFC45023.1 - 0.19 12.2 0.1 0.82 10.1 0.0 2.2 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain ThiF PF00899.21 EFC45024.1 - 2.8e-31 108.7 0.0 4.1e-18 65.6 0.0 2.8 2 2 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFC45024.1 - 9.4e-20 71.6 0.0 6.3e-19 68.9 0.0 2.4 1 1 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_4HB PF16191.5 EFC45024.1 - 2.7e-05 24.3 0.4 9.5e-05 22.5 0.4 1.9 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_FCCH PF16190.5 EFC45024.1 - 6.3e-05 23.1 0.2 0.00035 20.7 0.2 2.4 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain TrkA_N PF02254.18 EFC45024.1 - 0.0012 19.1 0.0 0.0039 17.4 0.0 1.9 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 EFC45024.1 - 0.0036 17.7 0.0 0.0099 16.3 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 EFC45024.1 - 0.013 15.6 0.0 0.044 13.8 0.0 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase KR PF08659.10 EFC45024.1 - 0.077 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 KR domain Phage_TAC_3 PF06896.11 EFC45024.1 - 0.95 10.1 6.4 21 5.8 0.0 3.8 3 0 0 3 3 3 0 Phage tail assembly chaperone proteins, TAC VWA PF00092.28 EFC45025.1 - 1.2e-10 41.9 7.5 3e-10 40.6 3.2 2.7 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC45025.1 - 2.2e-08 34.7 2.7 1.4e-07 32.1 0.1 3.4 3 1 1 4 4 4 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC45025.1 - 1e-07 32.0 0.2 2.6e-07 30.7 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2201 PF09967.9 EFC45025.1 - 4.9e-06 26.7 0.1 1.5e-05 25.1 0.1 1.9 1 0 0 1 1 1 1 VWA-like domain (DUF2201) VWA_CoxE PF05762.14 EFC45025.1 - 6.1e-05 22.5 0.2 0.00045 19.7 0.0 2.2 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein EF-hand_12 PF17901.1 EFC45025.1 - 0.41 11.2 3.8 3.9 8.0 0.3 3.7 3 0 0 3 3 3 0 EF-hand fold domain Mad3_BUB1_I PF08311.12 EFC45027.1 - 1.5e-38 131.5 0.7 2.6e-38 130.8 0.7 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.5 EFC45027.1 - 0.00017 21.7 0.0 0.00033 20.8 0.0 1.4 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein GyrI-like PF06445.15 EFC45028.1 - 0.0011 19.4 0.2 0.0014 19.0 0.2 1.4 1 0 0 1 1 1 1 GyrI-like small molecule binding domain 5-FTHF_cyc-lig PF01812.20 EFC45029.1 - 9.5e-32 110.3 0.0 2.6e-29 102.4 0.0 2.0 1 1 1 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family NikR_C PF08753.11 EFC45030.1 - 0.14 12.3 6.1 0.18 12.0 0.2 4.1 3 0 0 3 3 3 0 NikR C terminal nickel binding domain NPV_P10 PF05531.12 EFC45030.1 - 7.9 7.0 32.4 3.4 8.2 1.0 6.7 5 1 0 6 6 6 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 EFC45031.1 - 3.3e-48 164.3 0.1 1e-47 162.7 0.1 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45031.1 - 7e-35 120.6 0.0 1.5e-34 119.4 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase ZZ PF00569.17 EFC45031.1 - 2.7e-13 49.5 9.6 2.7e-13 49.5 9.6 3.3 4 0 0 4 4 2 1 Zinc finger, ZZ type TPR_2 PF07719.17 EFC45031.1 - 6.3e-13 47.8 8.1 0.007 16.4 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC45031.1 - 3.5e-09 36.1 11.4 0.0052 16.6 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45031.1 - 5.4e-09 36.4 5.4 0.022 15.3 0.1 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC45031.1 - 1.2e-07 31.4 3.8 0.18 12.1 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat PB1 PF00564.24 EFC45031.1 - 2.9e-07 30.3 1.0 0.00046 20.1 0.1 3.2 2 0 0 2 2 2 2 PB1 domain TPR_14 PF13428.6 EFC45031.1 - 7e-07 29.5 1.2 0.047 14.5 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC45031.1 - 3.8e-05 24.2 0.0 9.1 7.0 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat Pkinase_fungal PF17667.1 EFC45031.1 - 9.8e-05 21.3 0.2 0.00064 18.6 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase TPR_6 PF13174.6 EFC45031.1 - 0.00036 21.0 3.2 36 5.3 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC45031.1 - 0.001 19.2 0.0 0.037 14.2 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC45031.1 - 0.0021 18.3 5.8 7.5 6.9 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45031.1 - 0.0032 17.6 11.4 0.54 10.5 2.7 3.6 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 HEPN_AbiA_CTD PF18732.1 EFC45031.1 - 0.0081 16.1 0.9 2.5 8.1 0.0 3.5 3 0 0 3 3 3 1 HEPN like, Abia C-terminal domain TPR_17 PF13431.6 EFC45031.1 - 0.016 15.6 3.4 0.22 12.0 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat SurA_N_2 PF13623.6 EFC45031.1 - 0.019 14.8 0.0 0.063 13.1 0.0 1.9 1 0 0 1 1 1 0 SurA N-terminal domain Fis1_TPR_C PF14853.6 EFC45031.1 - 4.6 7.4 11.1 19 5.4 0.2 4.3 2 1 2 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Pkinase PF00069.25 EFC45032.1 - 1.3e-37 129.6 0.1 6.4e-34 117.5 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45032.1 - 3.4e-22 79.0 0.0 7.6e-22 77.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_2 PF07719.17 EFC45032.1 - 3.8e-11 42.2 17.3 0.00031 20.6 0.2 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45032.1 - 2.6e-09 37.2 15.2 4e-05 23.8 2.1 3.0 3 0 0 3 3 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFC45032.1 - 7.5e-08 32.6 7.6 0.00056 20.1 1.4 4.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45032.1 - 2.2e-07 31.3 5.0 0.043 14.3 0.0 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC45032.1 - 3.1e-07 29.9 23.6 0.0001 21.9 1.1 5.3 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC45032.1 - 2.2e-06 27.4 21.7 0.0083 16.3 0.8 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC45032.1 - 4.4e-06 26.3 3.1 0.4 10.8 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC45032.1 - 6.9e-06 26.6 0.1 0.1 13.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC45032.1 - 9.7e-06 26.0 0.0 0.056 14.3 0.0 4.8 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC45032.1 - 0.00049 20.5 8.5 7 7.5 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat Kdo PF06293.14 EFC45032.1 - 0.0035 16.7 0.0 0.0069 15.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPR_15 PF13429.6 EFC45032.1 - 0.0059 15.8 2.1 0.097 11.9 0.0 2.8 1 1 1 3 3 3 1 Tetratricopeptide repeat PB1 PF00564.24 EFC45032.1 - 0.0081 16.1 1.6 0.7 9.9 0.2 3.2 3 1 0 3 3 3 1 PB1 domain APH PF01636.23 EFC45032.1 - 0.055 13.4 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EFC45032.1 - 0.057 12.9 0.1 0.15 11.5 0.1 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Sel1 PF08238.12 EFC45032.1 - 0.35 11.6 4.0 2.2 9.1 0.2 3.7 4 0 0 4 4 4 0 Sel1 repeat UN_NPL4 PF11543.8 EFC45032.1 - 1 9.9 5.2 21 5.7 0.1 4.0 4 1 0 4 4 3 0 Nuclear pore localisation protein NPL4 MIT PF04212.18 EFC45032.1 - 1.3 9.2 10.6 13 6.0 0.1 4.6 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF4334 PF14232.6 EFC45033.1 - 6e-30 103.0 0.3 1.5e-29 101.7 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4334) GXWXG PF14231.6 EFC45033.1 - 1.1e-26 92.6 0.3 5e-26 90.5 0.1 2.0 2 0 0 2 2 2 1 GXWXG protein LRR_6 PF13516.6 EFC45034.1 - 4.5e-21 73.1 33.7 0.015 15.3 0.4 11.6 13 0 0 13 13 13 7 Leucine Rich repeat LRR_4 PF12799.7 EFC45034.1 - 1.4e-17 63.5 39.2 0.00031 21.0 0.1 9.3 6 3 2 9 9 9 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45034.1 - 3.8e-06 26.6 34.3 0.057 13.2 2.7 8.3 5 4 3 8 8 8 6 Leucine rich repeat LRR_9 PF14580.6 EFC45034.1 - 0.0009 18.8 16.0 0.44 10.0 0.5 4.7 2 2 2 5 5 5 4 Leucine-rich repeat LRR_1 PF00560.33 EFC45034.1 - 0.83 10.4 27.1 30 5.7 0.0 9.6 11 1 0 11 11 11 0 Leucine Rich Repeat DUF4116 PF13475.6 EFC45036.1 - 2.8e-98 321.5 0.9 5.3e-19 67.7 0.0 8.1 3 1 0 7 7 7 7 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC45036.1 - 5.5e-30 104.6 0.1 1.3e-29 103.4 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45036.1 - 2.3e-22 79.5 0.3 5e-22 78.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Rsbr_N PF08678.10 EFC45036.1 - 0.0005 20.2 0.8 7.3 6.7 0.0 5.0 3 1 2 6 6 6 2 Rsbr N terminal CbiG_C PF01890.16 EFC45036.1 - 0.0065 17.0 2.0 44 4.7 0.0 4.6 3 3 1 4 4 4 0 Cobalamin synthesis G C-terminus GST_C PF00043.25 EFC45036.1 - 0.13 12.5 3.4 41 4.5 0.1 4.3 3 2 0 3 3 3 0 Glutathione S-transferase, C-terminal domain NAD_binding_11 PF14833.6 EFC45036.1 - 0.23 11.7 5.0 8 6.7 0.0 4.7 4 2 1 6 6 6 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase LSM PF01423.22 EFC45037.1 - 3.3e-08 33.1 3.3 1.8e-07 30.8 3.3 2.1 1 1 0 1 1 1 1 LSM domain Hfq PF17209.3 EFC45037.1 - 0.087 12.5 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 Hfq protein ABC_tran PF00005.27 EFC45038.1 - 1.7e-19 70.7 0.0 4e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFC45038.1 - 0.0046 16.8 0.1 2.4 7.9 0.3 2.6 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 EFC45038.1 - 0.0082 16.5 0.0 0.017 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFC45038.1 - 0.0082 16.1 0.1 0.017 15.0 0.1 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC45038.1 - 0.015 15.0 0.1 0.046 13.5 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 EFC45038.1 - 0.019 14.4 3.4 0.095 12.1 0.2 2.6 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 EFC45038.1 - 0.036 14.6 0.1 0.036 14.6 0.1 2.1 2 0 0 2 2 1 0 AAA domain Septin PF00735.18 EFC45038.1 - 0.037 13.3 0.0 0.087 12.1 0.0 1.6 1 0 0 1 1 1 0 Septin AAA_22 PF13401.6 EFC45038.1 - 0.049 13.9 0.1 0.17 12.1 0.1 1.9 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EFC45038.1 - 0.068 13.3 0.1 0.21 11.7 0.1 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF87 PF01935.17 EFC45038.1 - 0.076 13.1 0.5 0.31 11.1 0.5 2.0 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_24 PF13479.6 EFC45038.1 - 0.14 11.9 0.6 0.38 10.4 0.2 1.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFC45038.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.12 EFC45038.1 - 0.15 11.9 0.1 0.45 10.4 0.1 1.8 1 0 0 1 1 1 0 NACHT domain FA_desaturase PF00487.24 EFC45039.1 - 2e-26 93.4 11.7 3.2e-26 92.7 11.7 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 EFC45039.1 - 1.3e-17 63.0 0.8 2.6e-17 62.0 0.8 1.5 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Filamin PF00630.19 EFC45040.1 - 2.5e-20 73.2 2.3 4.4e-14 53.2 0.1 2.8 2 0 0 2 2 2 2 Filamin/ABP280 repeat IpgD PF05925.12 EFC45040.1 - 1.3e-14 53.7 0.0 2.8e-12 46.0 0.0 2.3 2 0 0 2 2 2 2 Enterobacterial virulence protein IpgD CH PF00307.31 EFC45040.1 - 4e-10 39.8 7.8 3.8e-09 36.7 2.1 4.3 3 1 0 3 3 3 1 Calponin homology (CH) domain Invasin_D3 PF09134.10 EFC45040.1 - 0.00033 20.9 0.1 0.0025 18.1 0.2 2.3 2 0 0 2 2 2 1 Invasin, domain 3 YtkA PF13115.6 EFC45040.1 - 0.00039 21.0 4.1 0.35 11.5 0.2 3.3 4 0 0 4 4 4 2 YtkA-like RE_MjaI PF09568.10 EFC45040.1 - 0.0019 18.0 0.9 0.0073 16.1 0.9 2.0 1 0 0 1 1 1 1 MjaI restriction endonuclease Caprin-1_dimer PF18293.1 EFC45040.1 - 0.015 15.8 0.1 0.16 12.5 0.1 2.7 2 0 0 2 2 2 0 Caprin-1 dimerization domain AAA_assoc PF14363.6 EFC45040.1 - 0.49 10.8 8.0 0.54 10.6 0.0 3.9 3 1 1 4 4 4 0 Domain associated at C-terminal with AAA PEHE PF15275.6 EFC45040.1 - 2.6 8.7 7.0 0.47 11.1 1.7 2.6 3 0 0 3 3 3 0 PEHE domain tRNA-synt_1 PF00133.22 EFC45041.1 - 3.7e-189 629.9 4.6 4.1e-188 626.4 4.6 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFC45041.1 - 9.8e-33 113.3 0.1 3.1e-32 111.6 0.1 2.0 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFC45041.1 - 2.1e-17 63.0 6.2 4.9e-08 32.1 0.0 4.7 2 2 2 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 EFC45041.1 - 6.2e-07 29.1 0.2 4.7e-05 23.0 0.0 3.0 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 EFC45041.1 - 2.6e-06 27.0 0.6 0.02 14.2 0.1 3.0 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain PRANC PF09372.10 EFC45041.1 - 0.0099 16.2 2.8 1.3 9.4 0.3 3.7 2 0 0 2 2 2 1 PRANC domain DUF5063 PF16702.5 EFC45041.1 - 0.014 15.8 0.0 0.7 10.3 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5063) RasGEF PF00617.19 EFC45042.1 - 7.9e-32 110.9 0.5 7.9e-32 110.9 0.5 2.8 2 1 0 3 3 3 1 RasGEF domain LisH PF08513.11 EFC45042.1 - 0.098 12.7 0.2 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 LisH Med29 PF11568.8 EFC45042.1 - 2.1 8.6 7.5 7 6.9 0.1 3.4 3 0 0 3 3 3 0 Mediator complex subunit 29 Yip1 PF04893.17 EFC45043.1 - 3.7e-17 62.6 16.2 5.8e-17 61.9 16.2 1.4 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 EFC45043.1 - 0.17 11.6 9.3 0.34 10.7 9.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) DUF2070 PF09843.9 EFC45043.1 - 4 5.6 8.7 4.5 5.5 8.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF1298 PF06974.13 EFC45044.1 - 2.7e-29 102.0 0.3 5.1e-29 101.1 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) WES_acyltransf PF03007.16 EFC45044.1 - 7.8e-13 48.8 0.0 3.1e-12 46.8 0.0 2.1 1 1 0 1 1 1 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 EFC45044.1 - 0.00013 20.8 2.0 0.00034 19.4 0.0 2.2 2 0 0 2 2 2 1 Condensation domain DUF2227 PF09988.9 EFC45044.1 - 0.086 12.7 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized metal-binding protein (DUF2227) MgrB PF13998.6 EFC45044.1 - 2.1 8.3 4.7 15 5.6 1.2 2.5 2 0 0 2 2 2 0 MgrB protein CPSase_L_D2 PF02786.17 EFC45045.1 - 5.4e-81 271.1 0.0 8.3e-81 270.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFC45045.1 - 1.2e-46 157.8 0.1 1.3e-45 154.4 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFC45045.1 - 3.1e-34 117.3 0.0 1.9e-33 114.8 0.0 2.3 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 EFC45045.1 - 3e-16 59.0 2.3 7.1e-16 57.8 2.3 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 EFC45045.1 - 2.3e-10 40.3 0.0 5.9e-10 39.0 0.0 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 EFC45045.1 - 3.9e-09 36.3 0.1 8.1e-09 35.3 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EFC45045.1 - 4.1e-07 29.7 0.1 1.9e-06 27.6 0.0 2.2 2 1 0 2 2 2 1 Biotin-lipoyl like RimK PF08443.11 EFC45045.1 - 8.1e-06 25.6 0.0 0.00016 21.4 0.0 2.7 2 1 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EFC45045.1 - 0.00029 20.9 0.0 0.00055 20.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 EFC45045.1 - 0.00046 20.0 0.8 0.00086 19.1 0.1 1.8 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Sulf_coat_C PF12193.8 EFC45045.1 - 0.0028 17.7 0.0 0.073 13.1 0.0 2.3 2 0 0 2 2 2 1 Sulfolobus virus coat protein C terminal HlyD_3 PF13437.6 EFC45045.1 - 0.0086 16.8 0.1 2.9 8.7 0.0 3.2 3 0 0 3 3 3 1 HlyD family secretion protein ATP-grasp_4 PF13535.6 EFC45045.1 - 0.019 14.6 0.1 0.062 12.9 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain Cytochrom_D1 PF02239.16 EFC45045.1 - 0.023 13.2 0.2 0.081 11.4 0.1 1.9 2 0 0 2 2 2 0 Cytochrome D1 heme domain RnfC_N PF13375.6 EFC45045.1 - 0.032 14.2 0.0 0.18 11.8 0.1 2.2 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain ENT PF03735.14 EFC45047.1 - 2.3e-20 72.4 0.4 8.1e-20 70.7 0.4 1.9 1 0 0 1 1 1 1 ENT domain HSCB_C PF07743.13 EFC45047.1 - 0.065 13.7 6.7 0.15 12.5 3.6 2.9 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain DALR_1 PF05746.15 EFC45047.1 - 1.1 9.4 4.6 33 4.7 2.2 2.6 2 0 0 2 2 2 0 DALR anticodon binding domain Helicase_PWI PF18149.1 EFC45047.1 - 1.3 9.3 7.0 0.19 11.9 1.8 2.3 3 0 0 3 3 3 0 N-terminal helicase PWI domain NusB PF01029.18 EFC45047.1 - 1.7 8.9 5.7 0.61 10.3 1.9 2.2 2 0 0 2 2 2 0 NusB family FoP_duplication PF13865.6 EFC45047.1 - 2.2 8.9 6.9 1.7 9.2 0.8 2.4 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 Carboxyl_trans PF01039.22 EFC45048.1 - 7.7e-150 499.8 0.1 9.2e-150 499.5 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 EFC45048.1 - 0.0042 16.6 0.1 0.28 10.6 0.0 2.2 2 0 0 2 2 2 2 Malonate decarboxylase gamma subunit (MdcE) ACCA PF03255.14 EFC45048.1 - 0.06 13.2 0.1 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit MFS_1 PF07690.16 EFC45049.1 - 1.4e-08 34.1 45.5 7.7e-08 31.6 32.2 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily BTB PF00651.31 EFC45051.1 - 6.7e-23 81.0 0.4 1.4e-21 76.8 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 EFC45051.1 - 1.3e-09 38.1 1.6 2e-09 37.5 0.3 2.1 2 0 0 2 2 2 1 BTB And C-terminal Kelch MATH PF00917.26 EFC45051.1 - 5.6e-09 36.2 0.2 1.2e-08 35.1 0.1 1.6 2 0 0 2 2 2 1 MATH domain Kinesin PF00225.23 EFC45052.1 - 1.4e-95 320.1 1.3 1.4e-95 320.1 1.3 2.6 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC45052.1 - 1.8e-23 83.1 0.0 7.8e-23 81.1 0.0 2.1 1 0 0 1 1 1 1 Microtubule binding HHH_3 PF12836.7 EFC45052.1 - 1.2e-06 28.6 0.1 4.7e-06 26.8 0.1 2.0 1 1 1 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 EFC45052.1 - 0.1 13.2 2.5 0.79 10.4 0.2 3.1 3 0 0 3 3 3 0 Helix-hairpin-helix domain UPF0184 PF03670.13 EFC45052.1 - 0.2 12.1 3.9 0.95 9.9 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) TPR_2 PF07719.17 EFC45052.1 - 0.3 11.3 1.3 0.51 10.6 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat PBP1_TM PF14812.6 EFC45052.1 - 0.31 11.4 22.4 0.28 11.6 5.2 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3810 PF12725.7 EFC45053.1 - 0.069 12.5 6.2 0.045 13.1 4.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) DUF1746 PF08508.10 EFC45053.1 - 0.45 10.9 10.0 0.062 13.6 4.9 2.1 2 1 1 3 3 3 0 Fungal domain of unknown function (DUF1746) DHHC PF01529.20 EFC45053.1 - 1.1 9.4 8.3 9.2 6.4 2.7 2.4 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF3149 PF11346.8 EFC45054.1 - 0.054 13.1 0.2 4.6 6.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3149) MctB PF11382.8 EFC45054.1 - 0.069 12.8 0.0 0.49 10.1 0.0 1.9 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB BLOC1_2 PF10046.9 EFC45054.1 - 0.071 13.4 0.2 0.12 12.6 0.2 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Dad2 PF08654.10 EFC45054.1 - 0.072 13.5 0.1 0.12 12.8 0.1 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad2 DUF4404 PF14357.6 EFC45054.1 - 0.14 12.8 0.4 0.27 11.9 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Myb_DNA-binding PF00249.31 EFC45055.1 - 1.3e-11 44.5 4.2 5.2e-11 42.6 4.2 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC45055.1 - 1.2e-05 25.4 1.5 8.1e-05 22.8 1.5 2.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC45055.1 - 5.9e-05 22.9 0.3 0.00022 21.1 0.3 1.9 1 0 0 1 1 1 1 Myb DNA-binding like TEA PF01285.18 EFC45055.1 - 0.042 13.9 1.8 0.1 12.7 0.6 2.3 1 1 1 2 2 2 0 TEA/ATTS domain WD40 PF00400.32 EFC45057.1 - 3.4e-14 53.0 10.2 0.0015 19.3 0.1 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat NIF PF03031.18 EFC45058.1 - 5e-54 182.3 0.5 7.3e-54 181.8 0.5 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Trypsin PF00089.26 EFC45059.1 - 1.3e-43 149.4 1.6 1.3e-43 149.4 1.6 1.9 2 0 0 2 2 2 1 Trypsin Phage_int_SAM_6 PF18644.1 EFC45061.1 - 0.0011 18.9 0.8 0.0033 17.5 0.8 1.8 1 0 0 1 1 1 1 Phage integrase SAM-like domain CRF PF00473.17 EFC45061.1 - 0.11 12.6 1.8 1.6 8.8 0.0 2.7 2 0 0 2 2 2 0 Corticotropin-releasing factor family SIR2 PF02146.17 EFC45062.1 - 2.1e-29 102.7 2.4 7.4e-22 78.1 0.5 2.3 1 1 1 2 2 2 2 Sir2 family zf-C2H2_3 PF13878.6 EFC45062.1 - 0.72 9.7 3.0 0.88 9.4 0.2 2.4 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO A2L_zn_ribbon PF08792.10 EFC45062.1 - 1.6 8.6 6.4 9.6 6.1 0.2 3.1 3 0 0 3 3 3 0 A2L zinc ribbon domain LRR_8 PF13855.6 EFC45063.1 - 0.0002 21.0 0.8 0.43 10.4 0.0 5.1 6 1 0 6 6 6 2 Leucine rich repeat Zn_clus PF00172.18 EFC45064.1 - 0.00019 21.5 13.9 0.00037 20.6 13.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RabGAP-TBC PF00566.18 EFC45065.1 - 7.4e-52 176.1 0.2 7.4e-52 176.1 0.2 3.0 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Vps8 PF12816.7 EFC45065.1 - 2.4e-17 63.1 0.5 8.6e-17 61.3 0.5 2.0 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 zf-RING_11 PF17123.5 EFC45065.1 - 0.00016 21.3 1.9 0.00038 20.2 1.9 1.6 1 0 0 1 1 1 1 RING-like zinc finger ANAPC4_WD40 PF12894.7 EFC45065.1 - 0.0038 17.5 0.1 0.4 11.0 0.0 3.1 3 0 0 3 3 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC45065.1 - 0.0078 17.0 1.2 0.045 14.6 0.1 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat TMEM40 PF15817.5 EFC45065.1 - 0.084 12.6 0.1 0.4 10.5 0.1 2.2 1 0 0 1 1 1 0 Transmembrane protein 40 family zf-rbx1 PF12678.7 EFC45065.1 - 0.62 10.4 4.4 1.6 9.0 4.2 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFC45065.1 - 0.67 10.0 8.9 1.9 8.5 8.9 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-HC5HC2H PF13771.6 EFC45065.1 - 3.5 7.9 7.0 0.76 10.1 2.7 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain Atg14 PF10186.9 EFC45065.1 - 5.7 5.9 21.8 0.07 12.2 4.8 3.0 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 PHD PF00628.29 EFC45065.1 - 8.1 6.4 6.6 25 4.9 6.6 1.9 1 0 0 1 1 1 0 PHD-finger Ras PF00071.22 EFC45066.1 - 1.6e-13 50.6 0.0 2.2e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45066.1 - 4.5e-07 30.1 0.0 7.7e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EFC45066.1 - 0.002 18.1 0.2 0.17 11.9 0.2 2.2 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 EFC45066.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Steroid_dh PF02544.16 EFC45067.1 - 4.9e-37 127.2 2.4 6e-37 126.9 1.6 1.6 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase WW PF00397.26 EFC45067.1 - 0.079 13.1 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 WW domain BRK PF07533.16 EFC45067.1 - 0.14 11.8 0.0 0.4 10.4 0.0 1.8 1 0 0 1 1 1 0 BRK domain DUF1295 PF06966.12 EFC45067.1 - 0.34 10.4 2.9 0.68 9.4 2.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) BTB_2 PF02214.22 EFC45068.1 - 6.3e-12 45.7 2.7 3.3e-08 33.8 0.3 4.1 4 0 0 4 4 4 2 BTB/POZ domain DUF4777 PF16007.5 EFC45068.1 - 0.067 13.5 0.0 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) ThiF PF00899.21 EFC45069.1 - 8.3e-29 100.6 0.0 2e-28 99.4 0.0 1.6 1 1 0 1 1 1 1 ThiF family RasGAP PF00616.19 EFC45070.1 - 3.6e-39 134.7 5.1 3.6e-39 134.7 5.1 2.8 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 EFC45070.1 - 8.7e-11 42.1 2.2 8.7e-11 42.1 2.2 3.0 3 0 0 3 3 3 1 RasGAP C-terminus PNPase PF03726.14 EFC45070.1 - 2.2 8.8 5.8 1.3 9.6 1.1 3.2 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Myosin_TH1 PF06017.13 EFC45071.1 - 1.2e-34 119.7 4.0 2.9e-34 118.4 4.0 1.7 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Pkinase PF00069.25 EFC45071.1 - 0.0019 17.6 0.0 0.0066 15.8 0.0 1.9 1 0 0 1 1 1 1 Protein kinase domain STATa_Ig PF18214.1 EFC45071.1 - 0.011 15.8 1.0 0.051 13.6 0.1 2.5 2 0 0 2 2 2 0 STATa Immunoglobulin-like domain DIX PF00778.17 EFC45071.1 - 0.051 13.4 0.1 0.23 11.3 0.1 2.1 1 0 0 1 1 1 0 DIX domain Ras PF00071.22 EFC45072.1 - 1.5e-32 112.4 0.1 2.6e-32 111.6 0.1 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45072.1 - 9e-16 58.2 0.0 1.7e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45072.1 - 1.3e-07 31.3 0.0 2.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC45072.1 - 1.1e-06 28.4 0.2 2.9e-06 26.9 0.2 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC45072.1 - 3.6e-05 23.8 0.0 7.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC45072.1 - 0.00054 19.9 0.1 0.56 10.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 EFC45072.1 - 0.0027 17.5 2.0 0.0041 16.9 0.2 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 EFC45072.1 - 0.005 16.1 0.9 1 8.5 0.2 2.5 3 0 0 3 3 3 2 G-protein alpha subunit AAA_16 PF13191.6 EFC45072.1 - 0.18 12.2 0.1 0.42 11.0 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain 2TM PF13239.6 EFC45073.1 - 0.0013 19.0 32.8 0.0037 17.5 12.6 3.3 1 1 2 3 3 3 2 2TM domain DUF2070 PF09843.9 EFC45073.1 - 0.31 9.3 10.9 0.42 8.9 10.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PLDc_2 PF13091.6 EFC45074.1 - 5.1e-26 91.1 0.0 6.1e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 PLD-like domain Regulator_TrmB PF11495.8 EFC45074.1 - 0.036 13.3 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB CBAH PF02275.18 EFC45076.1 - 0.088 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Linear amide C-N hydrolases, choloylglycine hydrolase family Sin3a_C PF16879.5 EFC45077.1 - 1.1e-46 159.9 13.6 1.1e-46 159.9 13.6 2.9 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 EFC45077.1 - 1.4e-35 121.2 16.9 6.7e-19 67.8 3.9 4.9 5 0 0 5 5 5 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 EFC45077.1 - 4.6e-27 94.0 0.8 4.6e-27 94.0 0.8 3.1 3 0 0 3 3 3 1 Sin3 family co-repressor OrfB_IS605 PF01385.19 EFC45077.1 - 7.3 6.8 14.4 0.33 11.2 0.2 3.4 3 0 0 3 3 3 0 Probable transposase Mito_carr PF00153.27 EFC45078.1 - 1.2e-33 114.9 0.4 1.7e-15 56.7 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ank_5 PF13857.6 EFC45079.1 - 0.0005 20.3 0.1 0.081 13.3 0.0 3.1 2 1 0 2 2 2 2 Ankyrin repeats (many copies) ubiquitin PF00240.23 EFC45080.1 - 1.4e-14 53.5 0.0 1.5e-14 53.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC45080.1 - 2.3e-07 30.6 0.0 2.5e-07 30.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC45080.1 - 8.1e-05 22.9 0.0 8.5e-05 22.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_2 PF14560.6 EFC45080.1 - 0.00011 22.5 0.0 0.00044 20.6 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC45080.1 - 0.0013 18.8 0.0 0.0018 18.4 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 EFC45080.1 - 0.13 13.0 0.0 0.15 12.7 0.0 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD TUG-UBL1 PF11470.8 EFC45080.1 - 0.13 12.5 0.0 0.14 12.4 0.0 1.0 1 0 0 1 1 1 0 TUG ubiquitin-like domain GPS PF01825.21 EFC45083.1 - 1.6e-07 31.7 4.6 4.1e-07 30.4 4.6 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC45083.1 - 5.9e-06 26.5 7.8 1.9e-05 24.9 7.8 1.9 1 0 0 1 1 1 1 EGF-like domain RGS PF00615.19 EFC45083.1 - 7.8e-06 26.1 2.5 2.3e-05 24.6 2.5 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain EGF_alliinase PF04863.13 EFC45083.1 - 0.64 10.5 5.5 1.7 9.1 5.5 1.7 1 0 0 1 1 1 0 Alliinase EGF-like domain EGF_Tenascin PF18720.1 EFC45083.1 - 0.76 9.9 7.0 2 8.6 7.0 1.7 1 0 0 1 1 1 0 Tenascin EGF domain hEGF PF12661.7 EFC45083.1 - 0.8 10.4 6.9 2.5 8.9 6.9 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF DPM2 PF07297.12 EFC45083.1 - 0.83 10.0 11.9 0.057 13.7 5.4 2.6 2 0 0 2 2 2 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) F-box-like PF12937.7 EFC45084.1 - 0.052 13.4 0.1 0.15 11.9 0.1 1.8 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC45084.1 - 0.086 12.7 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 F-box domain zf-C3HC4_3 PF13920.6 EFC45085.1 - 3.3e-13 49.3 13.5 5.1e-13 48.7 13.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC45085.1 - 8.6e-06 25.5 14.9 1.5e-05 24.7 14.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFC45085.1 - 0.022 14.7 15.0 0.044 13.8 15.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Kinesin PF00225.23 EFC45086.1 - 4.5e-110 367.7 0.1 4.5e-110 367.7 0.1 2.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC45086.1 - 2.4e-24 86.0 0.0 2.4e-24 86.0 0.0 2.8 3 0 0 3 3 3 1 Microtubule binding RBD-FIP PF09457.10 EFC45086.1 - 0.01 15.8 0.5 0.051 13.5 0.5 2.4 1 0 0 1 1 1 1 FIP domain Flagellin_N PF00669.20 EFC45086.1 - 3.3 7.8 15.8 0.23 11.6 2.8 4.3 3 1 1 4 4 4 0 Bacterial flagellin N-terminal helical region AnmK PF03702.14 EFC45087.1 - 1.8e-73 247.8 0.0 9.4e-73 245.4 0.0 1.9 1 1 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase WD40 PF00400.32 EFC45088.1 - 7.2e-70 229.2 14.4 2.4e-08 34.5 0.0 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC45088.1 - 1.3e-24 86.2 0.8 1.8e-05 25.0 0.0 7.7 1 1 7 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC45088.1 - 8.3e-13 48.7 6.0 0.00067 19.6 0.1 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 EFC45088.1 - 5.6e-12 45.1 9.5 0.053 12.2 0.1 5.7 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 EFC45088.1 - 9.3e-12 44.9 5.9 0.0034 16.8 0.1 6.0 1 1 4 5 5 5 5 WD40-like domain Ge1_WD40 PF16529.5 EFC45088.1 - 5.3e-05 22.3 12.6 0.51 9.3 1.0 5.2 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein CEP19 PF14933.6 EFC45088.1 - 0.00011 22.5 0.0 0.00017 22.0 0.0 1.2 1 0 0 1 1 1 1 CEP19-like protein Frtz PF11768.8 EFC45088.1 - 0.0004 18.8 0.4 0.22 9.8 0.0 4.0 2 1 3 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz Me-amine-dh_H PF06433.11 EFC45088.1 - 0.0028 16.6 0.0 0.13 11.1 0.0 2.5 3 0 0 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) WD40_3 PF15911.5 EFC45088.1 - 0.04 13.9 0.3 6.1 6.9 0.0 3.3 2 1 1 3 3 3 0 WD domain, G-beta repeat DUF5639 PF18690.1 EFC45088.1 - 0.05 13.8 0.0 12 6.2 0.0 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5639) HTH_Tnp_IS1 PF12759.7 EFC45088.1 - 0.087 12.4 0.2 6.6 6.4 0.0 2.7 2 0 0 2 2 2 0 InsA C-terminal domain HPS3_N PF14761.6 EFC45088.1 - 0.11 12.1 0.6 1.3 8.5 0.1 2.5 1 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 NodS PF05401.11 EFC45088.1 - 0.12 11.9 2.1 8.6 5.9 0.1 3.4 3 1 0 4 4 4 0 Nodulation protein S (NodS) UPF0506 PF11703.8 EFC45088.1 - 0.72 10.3 8.7 8.8 6.8 0.9 4.0 3 1 0 3 3 3 0 UPF0506 LRR_6 PF13516.6 EFC45090.1 - 1.5e-14 52.7 20.2 0.073 13.2 0.0 8.9 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EFC45090.1 - 1.6e-09 37.9 30.1 0.00029 21.1 3.6 6.6 6 2 0 6 6 6 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC45090.1 - 0.0014 18.4 0.3 0.0034 17.2 0.3 1.6 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC45090.1 - 0.0017 18.6 18.5 7.4 7.6 0.2 8.5 8 0 0 8 8 8 1 Leucine Rich Repeat TetR_C_8 PF14278.6 EFC45090.1 - 0.013 15.6 0.4 0.039 14.0 0.4 1.8 1 0 0 1 1 1 0 Transcriptional regulator C-terminal region LRR_8 PF13855.6 EFC45090.1 - 0.015 15.1 4.9 0.015 15.1 4.9 7.1 5 3 1 6 6 6 0 Leucine rich repeat PHF5 PF03660.14 EFC45090.1 - 0.04 14.1 0.1 0.94 9.7 0.5 2.3 2 0 0 2 2 2 0 PHF5-like protein DUF3591 PF12157.8 EFC45091.1 - 1.6e-66 224.8 6.7 5e-66 223.2 6.7 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) Vac_Fusion PF02346.16 EFC45091.1 - 0.11 12.1 0.5 5.5 6.7 0.2 3.3 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Hydrolase_4 PF12146.8 EFC45092.1 - 3.5e-10 39.6 0.0 9.2e-10 38.2 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC45092.1 - 5.7e-10 39.3 0.0 3.9e-06 26.7 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC45092.1 - 3e-05 24.8 0.0 5.2e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EFC45092.1 - 0.0065 16.1 0.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 EFC45092.1 - 0.0078 15.7 0.0 0.066 12.7 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 EFC45092.1 - 0.011 15.3 0.1 0.46 10.0 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family BAAT_C PF08840.11 EFC45092.1 - 0.026 14.5 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 EFC45092.1 - 0.078 12.8 0.1 14 5.4 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase HSP70 PF00012.20 EFC45093.1 - 7.5e-243 807.1 10.0 8.5e-243 806.9 10.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC45093.1 - 1.2e-15 57.2 0.3 5.4e-14 51.8 0.1 2.3 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC45093.1 - 0.0073 15.6 0.2 0.18 11.0 0.1 2.5 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Spectrin PF00435.21 EFC45093.1 - 0.12 12.9 3.6 0.75 10.3 0.0 2.9 3 0 0 3 3 3 0 Spectrin repeat GLE1 PF07817.13 EFC45093.1 - 0.16 11.2 3.0 0.87 8.7 0.0 3.0 3 1 0 3 3 3 0 GLE1-like protein FtsA PF14450.6 EFC45093.1 - 0.67 10.4 6.4 8.9 6.8 0.2 3.7 3 2 0 3 3 3 0 Cell division protein FtsA MinE PF03776.14 EFC45094.1 - 0.047 13.7 0.4 0.11 12.5 0.4 1.6 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE CCM2_C PF16545.5 EFC45094.1 - 0.13 12.8 0.8 0.45 11.1 0.3 2.2 2 1 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology IU_nuc_hydro PF01156.19 EFC45095.1 - 6.4e-10 39.1 0.0 7.9e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase RNase_PH PF01138.21 EFC45096.1 - 1.9e-19 70.5 0.0 3.4e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFC45096.1 - 3.1e-13 49.5 1.5 6.4e-13 48.5 0.0 2.2 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 FMN_red PF03358.15 EFC45097.1 - 7.6e-13 48.5 0.1 1e-12 48.1 0.1 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_5 PF12724.7 EFC45097.1 - 5.2e-06 26.8 0.0 0.0042 17.3 0.0 2.2 1 1 1 2 2 2 2 Flavodoxin domain Flavodoxin_2 PF02525.17 EFC45097.1 - 3.5e-05 23.6 0.0 4.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 EFC45097.1 - 9.8e-05 22.6 0.0 0.00015 22.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin F5_F8_type_C PF00754.25 EFC45098.1 - 3.3e-08 33.7 0.0 9.2e-08 32.3 0.0 1.6 1 1 0 1 1 1 1 F5/8 type C domain Sad1_UNC PF07738.13 EFC45098.1 - 0.0002 21.4 0.2 0.00034 20.6 0.2 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal ANAPC10 PF03256.16 EFC45098.1 - 0.014 15.0 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) DUF659 PF04937.15 EFC45098.1 - 0.026 14.4 0.2 0.044 13.6 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF 659) Ribosomal_S7 PF00177.21 EFC45099.1 - 1.5e-36 125.3 0.8 1.9e-36 125.0 0.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e ANAPC4_WD40 PF12894.7 EFC45100.1 - 0.0066 16.7 0.0 3.8 7.9 0.0 3.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC45100.1 - 0.08 13.8 2.0 1.6 9.7 0.1 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Tweety PF04906.13 EFC45101.1 - 0.003 16.3 3.9 0.0067 15.1 3.9 1.7 1 1 0 1 1 1 1 Tweety Imm58 PF15581.6 EFC45101.1 - 0.063 13.4 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 58 DUF5569 PF17729.1 EFC45101.1 - 0.25 11.2 5.0 0.37 10.6 5.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5569) ADH_N PF08240.12 EFC45102.1 - 1.3e-12 47.5 0.1 4.1e-11 42.7 0.1 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Eno-Rase_NADH_b PF12242.8 EFC45102.1 - 0.00012 21.7 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ADH_zinc_N PF00107.26 EFC45102.1 - 0.052 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Shisa PF13908.6 EFC45103.1 - 0.0036 17.6 4.4 0.0036 17.6 4.4 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 EFC45103.1 - 0.083 13.9 0.3 0.56 11.2 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TMEM154 PF15102.6 EFC45103.1 - 2.1 8.3 6.1 0.27 11.1 1.1 2.0 2 0 0 2 2 2 0 TMEM154 protein family START PF01852.19 EFC45105.1 - 2.6e-08 33.5 0.7 5e-07 29.3 0.0 2.5 1 1 1 2 2 2 1 START domain DUF3074 PF11274.8 EFC45105.1 - 0.0074 16.3 0.0 0.015 15.3 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3074) ACOX PF01756.19 EFC45107.1 - 1.6e-32 112.5 0.0 3.1e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 EFC45107.1 - 8.4e-15 54.8 0.0 1.9e-14 53.6 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 EFC45107.1 - 2.4e-05 24.6 0.0 5.8e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 EFC45107.1 - 0.00021 21.8 0.0 0.00051 20.6 0.0 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal MCU PF04678.13 EFC45109.1 - 7.6e-47 159.7 0.6 1.3e-46 159.0 0.6 1.4 1 0 0 1 1 1 1 Mitochondrial calcium uniporter COR PF16095.5 EFC45109.1 - 1.7e-05 24.7 0.3 1.7e-05 24.7 0.3 1.9 2 1 0 2 2 2 1 C-terminal of Roc, COR, domain ADSL_C PF10397.9 EFC45109.1 - 0.043 14.4 0.2 0.14 12.7 0.2 1.9 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminus M60-like_N PF17291.2 EFC45109.1 - 0.084 12.8 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 N-terminal domain of M60-like peptidases Tubulin PF00091.25 EFC45110.1 - 8.1e-70 235.0 0.4 1.8e-69 233.9 0.1 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC45110.1 - 2.6e-36 124.6 0.2 4.3e-36 123.9 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC45110.1 - 1.5e-06 28.5 0.0 3.7e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFC45110.1 - 0.0086 15.8 0.0 0.023 14.4 0.0 1.7 1 0 0 1 1 1 1 Tubulin domain NmrA PF05368.13 EFC45111.1 - 8.7e-10 38.5 0.0 1.7e-09 37.6 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family Gp_dh_N PF00044.24 EFC45111.1 - 0.00085 19.6 0.5 1.7 9.0 0.1 3.1 2 1 1 3 3 3 2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 EFC45111.1 - 0.03 14.2 0.0 0.4 10.5 0.0 2.2 2 0 0 2 2 2 0 NAD(P)H-binding Hat1_N PF10394.9 EFC45111.1 - 0.28 11.4 3.9 0.44 10.8 2.5 2.1 2 1 0 2 2 2 0 Histone acetyl transferase HAT1 N-terminus Peptidase_C1 PF00112.23 EFC45112.1 - 1.3e-58 198.6 1.0 1.6e-58 198.4 1.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC45112.1 - 0.82 8.4 5.2 0.19 10.4 0.2 2.3 2 1 1 3 3 3 0 Peptidase C1-like family Guanylate_cyc PF00211.20 EFC45113.1 - 1.9e-51 174.3 0.0 4.7e-51 173.0 0.0 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC45113.1 - 2.2e-15 56.8 0.0 7e-15 55.2 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC45113.1 - 4.2e-10 39.6 0.3 1.2e-09 38.1 0.0 2.0 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 EFC45113.1 - 3.1e-05 24.2 0.0 5.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC45113.1 - 0.00057 19.9 0.0 0.0014 18.6 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS_2 PF08446.11 EFC45113.1 - 0.028 15.1 0.0 0.12 13.0 0.0 2.1 1 0 0 1 1 1 0 PAS fold PAS_7 PF12860.7 EFC45113.1 - 0.051 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold tRNA_bind_2 PF13725.6 EFC45114.1 - 0.11 12.2 4.4 0.23 11.1 4.4 1.5 1 0 0 1 1 1 0 Possible tRNA binding domain LRR_4 PF12799.7 EFC45114.1 - 2.5 8.6 33.0 19 5.9 0.1 8.5 5 3 4 9 9 9 0 Leucine Rich repeats (2 copies) RGS PF00615.19 EFC45115.1 - 9.7e-05 22.6 2.4 0.00028 21.1 2.4 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain Antistasin PF02822.14 EFC45116.1 - 0.0051 17.4 10.3 0.0051 17.4 10.3 2.6 2 0 0 2 2 2 2 Antistasin family EFG_II PF14492.6 EFC45117.1 - 0.11 12.6 1.4 6.3 7.0 0.0 3.2 4 0 0 4 4 4 0 Elongation Factor G, domain II START PF01852.19 EFC45118.1 - 7.3e-07 28.8 0.0 1.5e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 START domain AAA PF00004.29 EFC45119.1 - 3.1e-08 34.1 0.2 0.0048 17.3 0.0 4.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFC45119.1 - 4.4e-07 30.0 0.6 0.00067 19.7 0.0 5.2 5 0 0 5 5 5 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC45119.1 - 0.00058 20.3 0.1 2.2 8.6 0.0 4.6 5 0 0 5 5 5 1 AAA ATPase domain AAA_22 PF13401.6 EFC45119.1 - 0.0012 19.1 0.2 0.036 14.3 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_7 PF12775.7 EFC45119.1 - 0.0014 18.2 1.0 0.2 11.2 0.0 3.5 3 0 0 3 3 3 1 P-loop containing dynein motor region zf-C3HC4_3 PF13920.6 EFC45119.1 - 0.21 11.5 20.6 0.2 11.6 11.0 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RNA_helicase PF00910.22 EFC45119.1 - 1.1 9.7 4.7 5.8 7.4 0.0 4.7 5 0 0 5 5 5 0 RNA helicase DNA_ligase_A_C PF04679.15 EFC45120.1 - 1.2e-17 64.3 0.0 1.8e-17 63.7 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region Hormone_3 PF00159.18 EFC45120.1 - 0.045 13.8 0.0 0.094 12.8 0.0 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide DNA_ligase_OB_2 PF14743.6 EFC45120.1 - 0.11 12.6 0.1 6.9 6.8 0.0 2.3 2 0 0 2 2 2 0 DNA ligase OB-like domain CDC45 PF02724.14 EFC45120.1 - 0.18 10.1 0.0 0.18 10.1 0.0 1.0 1 0 0 1 1 1 0 CDC45-like protein IF3_C PF00707.22 EFC45121.1 - 0.0022 17.9 0.5 0.0027 17.6 0.5 1.2 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain Halogen_Hydrol PF10112.9 EFC45121.1 - 0.15 12.0 2.1 0.2 11.7 2.1 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein SCVP PF17619.2 EFC45121.1 - 0.31 11.9 3.1 0.69 10.8 2.7 1.7 1 1 1 2 2 2 0 Secreted clade V proteins ARPC4 PF05856.12 EFC45122.1 - 3.1e-28 98.5 1.1 3.7e-28 98.2 1.1 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) adh_short PF00106.25 EFC45124.1 - 4e-14 52.5 0.0 3.4e-09 36.4 0.0 2.5 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC45124.1 - 9.1e-10 38.5 0.0 0.00012 21.8 0.0 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase F-box-like PF12937.7 EFC45124.1 - 0.00064 19.6 0.0 0.0016 18.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like Pentapeptide PF00805.22 EFC45125.1 - 3.3e-21 74.5 18.0 1.9e-10 40.2 1.9 4.7 2 1 2 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC45125.1 - 1.3e-17 63.7 22.5 3.3e-10 40.0 6.6 3.8 1 1 1 3 3 3 3 Pentapeptide repeats (9 copies) TLD PF07534.16 EFC45125.1 - 3e-16 59.9 4.3 3e-16 59.9 4.3 2.5 3 0 0 3 3 3 1 TLD Pentapeptide_3 PF13576.6 EFC45125.1 - 1.2e-09 38.1 17.0 5.6e-05 23.2 5.5 4.6 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC45125.1 - 0.00032 21.0 0.0 0.0014 18.9 0.0 2.2 1 0 0 1 1 1 1 BTB/POZ domain zf-C3HC4 PF00097.25 EFC45125.1 - 0.005 16.7 10.7 0.005 16.7 10.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC45125.1 - 0.013 15.5 8.3 0.048 13.7 8.3 2.1 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFC45125.1 - 0.018 14.9 6.4 0.018 14.9 6.4 2.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC45125.1 - 0.034 14.0 11.5 0.15 11.9 11.5 2.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 EFC45125.1 - 0.13 13.0 0.2 0.13 13.0 0.2 3.1 3 0 0 3 3 1 0 TRAF-type zinc finger zf-RING_2 PF13639.6 EFC45125.1 - 0.15 12.4 14.2 0.059 13.7 10.1 2.7 2 0 0 2 2 2 0 Ring finger domain TMPIT PF07851.13 EFC45125.1 - 1.5 8.0 7.4 3.6 6.8 7.4 1.6 1 0 0 1 1 1 0 TMPIT-like protein zf-C3HC4_4 PF15227.6 EFC45125.1 - 1.6 9.0 10.7 11 6.3 10.7 2.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Herpes_BLRF2 PF05812.12 EFC45125.1 - 3.1 7.9 10.3 6.8 6.9 10.3 1.5 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein Histidinol_dh PF00815.20 EFC45125.1 - 5.6 5.9 6.0 8.9 5.2 6.0 1.2 1 0 0 1 1 1 0 Histidinol dehydrogenase zf-RING_5 PF14634.6 EFC45125.1 - 8.8 6.4 20.2 0.034 14.1 9.3 2.7 3 0 0 3 3 3 0 zinc-RING finger domain DUF2309 PF10070.9 EFC45126.1 - 0.21 9.9 6.0 0.29 9.4 6.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) Anillin_N PF16018.5 EFC45126.1 - 0.25 12.0 0.2 0.25 12.0 0.2 3.9 3 1 1 4 4 4 0 Anillin N-terminus Golgin_A5 PF09787.9 EFC45126.1 - 0.25 10.8 41.5 0.042 13.3 24.4 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 KfrA_N PF11740.8 EFC45126.1 - 0.53 11.0 11.4 5.8 7.6 0.2 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term PIN_3 PF13470.6 EFC45126.1 - 1.5 9.6 4.8 8.7 7.1 4.8 2.4 1 1 0 1 1 1 0 PIN domain FPP PF05911.11 EFC45126.1 - 1.6 6.8 41.3 0.13 10.5 5.3 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil FliD_N PF02465.18 EFC45126.1 - 1.7 9.4 25.3 2 9.1 0.1 3.8 1 1 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Muted PF14942.6 EFC45126.1 - 7.3 6.9 36.2 5 7.5 17.8 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein RIH_assoc PF08454.11 EFC45126.1 - 7.3 6.5 9.5 0.29 11.0 0.7 2.5 1 1 1 2 2 2 0 RyR and IP3R Homology associated OmpH PF03938.14 EFC45126.1 - 9.7 6.5 46.0 3.1 8.1 20.0 3.1 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) Glyco_hydro_44 PF12891.7 EFC45127.1 - 4.6e-68 229.6 8.4 8.7e-68 228.7 5.4 2.1 2 0 0 2 2 2 1 Glycoside hydrolase family 44 Porphyrn_cat_1 PF18206.1 EFC45127.1 - 0.055 14.1 0.1 0.17 12.5 0.1 1.8 1 0 0 1 1 1 0 Porphyranase catalytic subdomain 1 Big_1 PF02369.16 EFC45127.1 - 2.3 8.3 9.5 0.63 10.1 4.3 2.6 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) TPR_12 PF13424.6 EFC45128.1 - 3.8e-05 23.9 1.8 8.5e-05 22.8 1.8 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat UDG PF03167.19 EFC45129.1 - 4.6e-23 81.9 0.0 6.2e-23 81.5 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily CIMR PF00878.18 EFC45130.1 - 6.3e-10 39.3 1.3 4.3e-08 33.3 0.2 3.0 3 0 0 3 3 3 2 Cation-independent mannose-6-phosphate receptor repeat LRR_6 PF13516.6 EFC45131.1 - 1.6e-26 90.1 0.4 4.6e-05 23.1 0.0 5.7 6 0 0 6 6 6 5 Leucine Rich repeat LRR_4 PF12799.7 EFC45131.1 - 6.2e-13 48.7 1.7 0.001 19.4 0.0 4.4 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45131.1 - 2.7e-12 46.3 0.5 1.6e-05 24.6 0.0 3.5 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EFC45131.1 - 5.6e-06 26.2 0.3 80 4.4 0.0 6.3 7 0 0 7 7 7 0 Leucine Rich Repeat ApoB100_C PF12491.8 EFC45131.1 - 0.0065 16.4 9.7 1.5 8.8 0.3 5.4 2 2 4 6 6 6 1 Apolipoprotein B100 C terminal DUF5490 PF17593.2 EFC45131.1 - 0.02 14.9 2.1 6.4 6.9 0.0 5.0 3 2 3 6 6 6 0 Family of unknown function (DUF5490) Apo-VLDL-II PF05418.11 EFC45131.1 - 0.032 14.8 1.3 65 4.2 0.1 3.8 2 1 2 4 4 4 0 Apovitellenin I (Apo-VLDL-II) Polo_box_2 PF18531.1 EFC45131.1 - 0.24 11.6 2.1 4.9 7.3 0.3 2.9 1 1 3 4 4 4 0 Polo box domain UPF0193 PF05250.11 EFC45131.1 - 0.7 9.6 10.4 4.3 7.1 0.3 3.2 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0193) DUF3127 PF11325.8 EFC45133.1 - 0.088 13.1 0.1 0.37 11.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3127) DUF4116 PF13475.6 EFC45134.1 - 3.4e-44 148.4 24.3 2.7e-08 33.4 0.8 9.5 8 2 1 9 9 9 7 Domain of unknown function (DUF4116) Tetraspanin PF00335.20 EFC45135.1 - 0.0038 17.0 1.4 0.005 16.6 1.4 1.5 1 1 0 1 1 1 1 Tetraspanin family Chi-conotoxin PF16981.5 EFC45135.1 - 0.017 15.3 0.3 0.042 14.1 0.3 1.7 1 0 0 1 1 1 0 chi-Conotoxin or t superfamily Ependymin PF00811.18 EFC45135.1 - 0.019 15.2 1.6 0.054 13.7 1.6 1.8 1 1 0 1 1 1 0 Ependymin RGS PF00615.19 EFC45136.1 - 8.3e-07 29.3 4.3 8.7e-06 26.0 4.3 3.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain ACDC PF14733.6 EFC45136.1 - 0.26 11.6 4.3 0.61 10.4 0.1 3.8 3 0 0 3 3 3 0 AP2-coincident C-terminal DUF5097 PF17020.5 EFC45136.1 - 0.37 11.1 6.1 1 9.7 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5097) Filo_VP24 PF06389.11 EFC45137.1 - 0.013 15.0 0.1 0.016 14.8 0.1 1.2 1 0 0 1 1 1 0 Filovirus membrane-associated protein VP24 Zn_clus PF00172.18 EFC45138.1 - 0.0001 22.3 7.6 0.00019 21.5 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PALP PF00291.25 EFC45139.1 - 7.7e-65 219.2 0.0 8.6e-65 219.0 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF4116 PF13475.6 EFC45140.1 - 5e-27 93.4 37.4 1.2e-05 24.9 1.3 10.7 4 3 8 12 12 12 10 Domain of unknown function (DUF4116) Cons_hypoth95 PF03602.15 EFC45140.1 - 0.00049 19.8 0.0 1.1 8.8 0.0 2.5 2 0 0 2 2 2 2 Conserved hypothetical protein 95 MNNL PF07657.13 EFC45140.1 - 0.13 12.4 0.1 0.31 11.1 0.1 1.6 1 0 0 1 1 1 0 N terminus of Notch ligand NHL PF01436.21 EFC45142.1 - 0.00048 20.0 0.0 0.0082 16.1 0.0 2.6 2 0 0 2 2 2 1 NHL repeat NmrA PF05368.13 EFC45143.1 - 7.3e-32 110.8 2.0 9.3e-32 110.4 2.0 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC45143.1 - 1.1e-19 71.1 0.6 2.7e-19 69.8 0.3 1.8 1 1 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFC45143.1 - 2.1e-07 30.2 0.3 3.9e-07 29.4 0.3 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC45143.1 - 1.9e-06 27.5 1.5 5.2e-06 26.1 0.5 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFC45143.1 - 0.00019 21.8 2.1 0.00064 20.2 0.8 2.0 1 1 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 EFC45143.1 - 0.00039 19.7 0.1 0.001 18.3 0.1 1.8 2 0 0 2 2 2 1 Male sterility protein TrkA_N PF02254.18 EFC45143.1 - 0.00056 20.2 1.0 0.0024 18.1 0.7 2.0 2 0 0 2 2 2 1 TrkA-N domain KR PF08659.10 EFC45143.1 - 0.0038 17.2 0.3 0.0064 16.4 0.3 1.4 1 0 0 1 1 1 1 KR domain DapB_N PF01113.20 EFC45143.1 - 0.0065 16.6 1.3 0.0065 16.6 1.3 2.0 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus PdxJ PF03740.13 EFC45143.1 - 0.011 14.8 0.2 0.039 13.1 0.0 1.8 2 1 0 2 2 2 0 Pyridoxal phosphate biosynthesis protein PdxJ Sigma54_activ_2 PF14532.6 EFC45143.1 - 0.093 12.8 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain SpoU_sub_bind PF08032.12 EFC45143.1 - 0.44 10.9 2.5 4.2 7.7 0.2 2.9 2 1 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding Ras PF00071.22 EFC45144.1 - 2.7e-08 33.6 0.1 2.1e-06 27.5 0.1 3.1 2 1 0 2 2 2 1 Ras family Roc PF08477.13 EFC45144.1 - 0.00011 22.4 0.0 0.0031 17.7 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase zf-C3HC4_3 PF13920.6 EFC45145.1 - 2.8e-09 36.7 11.6 4.5e-09 36.0 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC45145.1 - 7e-09 35.4 11.7 1.2e-08 34.6 11.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC45145.1 - 6e-07 29.7 12.4 9.9e-07 29.0 12.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFC45145.1 - 2e-06 27.5 13.6 3.4e-06 26.8 13.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC45145.1 - 3.8e-06 26.8 5.5 3.8e-06 26.8 5.5 2.1 1 1 1 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 EFC45145.1 - 7.3e-06 25.7 12.1 1.2e-05 25.0 12.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-P11 PF03854.14 EFC45145.1 - 0.00018 21.1 7.8 0.00035 20.2 7.8 1.5 1 0 0 1 1 1 1 P-11 zinc finger zf-RING_5 PF14634.6 EFC45145.1 - 0.00043 20.2 12.8 0.001 18.9 12.7 1.8 1 1 0 1 1 1 1 zinc-RING finger domain Ank_4 PF13637.6 EFC45145.1 - 0.0082 16.7 0.1 0.034 14.7 0.0 2.2 3 0 0 3 3 1 1 Ankyrin repeats (many copies) zf-RING_4 PF14570.6 EFC45145.1 - 0.0094 15.7 9.7 0.042 13.7 9.6 2.0 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 EFC45145.1 - 0.01 15.7 4.7 0.018 14.9 4.7 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EFC45145.1 - 0.031 14.6 9.5 0.07 13.4 9.5 1.5 1 1 0 1 1 1 0 RING-H2 zinc finger domain Ank PF00023.30 EFC45145.1 - 0.15 12.5 0.0 0.53 10.8 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeat PAP_PilO PF06864.12 EFC45145.1 - 0.16 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) zf-C3HC4_4 PF15227.6 EFC45145.1 - 0.22 11.7 11.3 0.68 10.1 11.4 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EFC45145.1 - 0.4 10.5 7.5 1.5 8.7 7.5 2.0 1 1 0 1 1 1 0 RING-like zinc finger FYVE PF01363.21 EFC45145.1 - 4.6 7.4 11.9 22 5.3 11.9 2.1 1 1 0 1 1 1 0 FYVE zinc finger HMG_box PF00505.19 EFC45146.1 - 2.5e-20 72.7 14.9 1.4e-13 51.0 2.7 2.7 3 0 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC45146.1 - 8.8e-15 55.1 20.9 4.6e-08 33.5 3.1 2.7 2 1 0 2 2 2 2 HMG-box domain DUF2057 PF09829.9 EFC45146.1 - 0.031 14.4 13.6 0.7 10.0 0.2 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Eno-Rase_FAD_bd PF07055.12 EFC45146.1 - 0.091 13.2 6.2 0.24 11.9 0.8 2.4 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain CCDC71L PF15374.6 EFC45146.1 - 0.21 10.8 22.3 0.28 10.4 22.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L LPD11 PF18824.1 EFC45146.1 - 0.24 11.5 5.7 1.7 8.8 1.4 2.4 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 11 SAPS PF04499.15 EFC45146.1 - 1.5 7.6 16.4 1.8 7.3 16.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4407 PF14362.6 EFC45146.1 - 4.2 6.6 21.3 5 6.4 21.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3106 PF11304.8 EFC45146.1 - 6.5 7.3 20.4 1.3 9.5 0.5 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) EF-hand_1 PF00036.32 EFC45147.1 - 1.3e-11 43.1 2.0 2.9e-07 29.6 0.3 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC45147.1 - 1.1e-08 35.4 0.8 0.00035 21.0 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC45147.1 - 7.5e-08 31.7 4.3 0.019 14.9 0.4 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EFC45147.1 - 0.00026 20.3 1.5 0.0082 15.6 0.3 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFC45147.1 - 0.00029 20.6 0.7 0.0043 16.9 0.1 3.0 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_4 PF12763.7 EFC45147.1 - 0.0042 17.0 4.7 0.11 12.5 0.1 2.9 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand ICAP-1_inte_bdg PF10480.9 EFC45147.1 - 7.7 6.5 8.8 14 5.6 8.8 1.4 1 0 0 1 1 1 0 Beta-1 integrin binding protein EGF_2 PF07974.13 EFC45148.1 - 5.9e-40 135.3 142.4 2e-06 28.0 11.0 9.9 9 0 0 9 9 9 9 EGF-like domain MORN PF02493.20 EFC45148.1 - 0.00032 20.4 1.6 7.1 6.7 0.2 6.2 6 0 0 6 6 6 1 MORN repeat EGF PF00008.27 EFC45148.1 - 0.012 15.9 4.9 0.012 15.9 4.9 11.2 11 1 0 11 11 11 0 EGF-like domain Kelch_6 PF13964.6 EFC45149.1 - 1.9e-06 27.9 4.3 0.15 12.4 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 EFC45149.1 - 0.0033 17.4 0.2 1.5 8.9 0.1 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 EFC45149.1 - 0.0034 17.4 4.9 2.1 8.4 0.5 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC45149.1 - 0.051 13.9 1.7 3.9 7.9 0.2 3.6 3 1 0 3 3 3 0 Galactose oxidase, central domain WAK PF08488.11 EFC45149.1 - 0.21 12.1 1.1 0.36 11.4 0.4 1.7 2 0 0 2 2 2 0 Wall-associated kinase Kelch_1 PF01344.25 EFC45149.1 - 0.33 10.6 6.9 4.5 6.9 0.8 3.7 5 0 0 5 5 5 0 Kelch motif 2_5_RNA_ligase2 PF13563.6 EFC45150.1 - 1.7e-25 89.7 0.0 2.2e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily CPDase PF07823.11 EFC45150.1 - 7.4e-05 22.5 0.7 0.022 14.4 0.0 2.1 1 1 1 2 2 2 2 Cyclic phosphodiesterase-like protein LigT_PEase PF02834.16 EFC45150.1 - 0.031 14.5 0.0 0.099 12.8 0.0 1.9 2 0 0 2 2 2 0 LigT like Phosphoesterase PAP2_C PF14360.6 EFC45151.1 - 3.5e-25 88.3 8.5 3.5e-25 88.3 8.5 3.4 2 1 1 3 3 3 1 PAP2 superfamily C-terminal PAP2_3 PF14378.6 EFC45151.1 - 0.0031 17.2 13.2 0.0089 15.7 8.5 2.2 2 0 0 2 2 2 1 PAP2 superfamily DUF2207 PF09972.9 EFC45151.1 - 0.061 12.1 0.7 0.1 11.3 0.3 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Lig_chan PF00060.26 EFC45151.1 - 0.23 11.3 0.8 0.57 10.0 0.8 1.7 1 0 0 1 1 1 0 Ligand-gated ion channel PAP2 PF01569.21 EFC45151.1 - 0.78 9.5 17.1 0.1 12.4 10.7 2.6 1 1 2 3 3 3 0 PAP2 superfamily Archaeal_AmoA PF12942.7 EFC45152.1 - 0.021 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Archaeal ammonia monooxygenase subunit A (AmoA) NDK PF00334.19 EFC45153.1 - 7.2e-55 184.7 0.1 1.5e-26 93.0 0.0 3.2 2 1 1 3 3 3 3 Nucleoside diphosphate kinase DUF1126 PF06565.12 EFC45153.1 - 0.0014 18.5 0.7 0.0025 17.6 0.7 1.5 1 0 0 1 1 1 1 DUF1126 PH-like domain HU-DNA_bdg PF14848.6 EFC45153.1 - 0.016 15.2 0.1 0.036 14.1 0.1 1.6 1 0 0 1 1 1 0 DNA-binding domain HAD_2 PF13419.6 EFC45154.1 - 5.7e-05 23.3 0.5 0.00024 21.3 0.5 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFC45154.1 - 0.011 16.0 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 EFC45154.1 - 0.067 13.0 0.0 0.25 11.2 0.0 1.8 2 1 0 2 2 2 0 Acid Phosphatase Ras_bdg_2 PF14847.6 EFC45154.1 - 0.099 13.0 0.3 0.42 11.0 0.1 2.1 2 0 0 2 2 2 0 Ras-binding domain of Byr2 DNA_ligase_A_M PF01068.21 EFC45155.1 - 4.9e-32 111.2 0.0 1.4e-31 109.7 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 EFC45155.1 - 1.7e-17 63.8 0.0 4e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 EFC45155.1 - 2.1e-05 24.9 0.0 6.3e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 RNA ligase eIF3_N PF09440.10 EFC45156.1 - 2.7e-26 92.6 9.8 2.7e-26 92.6 9.8 2.6 4 1 0 4 4 4 1 eIF3 subunit 6 N terminal domain ANAPC3 PF12895.7 EFC45156.1 - 0.021 15.0 3.4 0.067 13.4 3.4 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 EDS1_EP PF18117.1 EFC45156.1 - 3.6 8.1 9.1 1.1 9.8 2.1 3.0 3 0 0 3 3 3 0 Enhanced disease susceptibility 1 protein EP domain Adhesin_P1_N PF18652.1 EFC45156.1 - 8.5 6.5 7.0 10 6.2 2.0 2.9 2 0 0 2 2 2 0 Adhesin P1 N-terminal domain NurA PF09376.10 EFC45157.1 - 0.071 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 NurA domain F-box-like PF12937.7 EFC45157.1 - 0.19 11.6 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 F-box-like VWA_2 PF13519.6 EFC45158.1 - 7.9e-10 39.3 0.1 8.9e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain Med25_VWA PF11265.8 EFC45158.1 - 0.0031 17.4 0.0 0.0056 16.5 0.0 1.4 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Ank_4 PF13637.6 EFC45159.1 - 6.9e-11 42.5 0.0 0.037 14.6 0.0 5.0 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC45159.1 - 7.9e-10 39.2 0.0 0.0091 16.6 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC45159.1 - 4.4e-06 26.6 0.0 22 6.0 0.0 6.2 6 0 0 6 6 6 1 Ankyrin repeat F-box-like PF12937.7 EFC45159.1 - 5.3e-05 23.0 0.1 0.00014 21.7 0.1 1.7 1 0 0 1 1 1 1 F-box-like Ank PF00023.30 EFC45159.1 - 0.00036 20.8 0.0 2.2 8.9 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 EFC45159.1 - 0.0068 16.7 0.2 16 6.0 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeats (many copies) F-box PF00646.33 EFC45159.1 - 0.065 13.1 0.5 0.41 10.6 0.1 2.6 2 0 0 2 2 2 0 F-box domain SR-25 PF10500.9 EFC45159.1 - 0.12 12.0 17.7 0.21 11.2 17.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 EFC45160.1 - 1.1e-37 129.9 0.1 1.6e-37 129.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45160.1 - 1.3e-28 100.0 0.0 2.2e-28 99.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45160.1 - 7.1e-05 21.8 0.1 0.00013 20.9 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC45160.1 - 0.0016 17.9 0.0 0.0034 16.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like EGF_2 PF07974.13 EFC45161.1 - 0.00015 22.0 8.4 0.00015 22.0 8.4 8.5 9 4 1 10 10 10 1 EGF-like domain LEAP-2 PF07359.11 EFC45161.1 - 7.6 6.4 7.8 0.55 10.1 0.9 2.8 2 1 1 3 3 3 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) NHL PF01436.21 EFC45162.1 - 6.1e-106 341.5 9.2 9.5e-10 38.0 0.0 16.0 16 0 0 16 16 16 13 NHL repeat Pkinase PF00069.25 EFC45162.1 - 5.4e-50 170.2 0.8 9.8e-50 169.4 0.8 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45162.1 - 1.4e-29 103.2 0.1 2.5e-29 102.3 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC45162.1 - 3.5e-22 78.5 159.5 6.8e-05 23.1 10.8 10.1 10 0 0 10 10 10 9 EGF-like domain SGL PF08450.12 EFC45162.1 - 1.7e-12 47.5 8.7 0.022 14.4 0.1 7.7 3 2 3 7 7 7 3 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC45162.1 - 4.3e-05 23.6 4.5 78 3.1 0.0 8.1 4 3 3 11 11 11 0 Esterase-like activity of phytase Pkinase_fungal PF17667.1 EFC45162.1 - 0.00044 19.1 0.0 0.00074 18.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase TMEM154 PF15102.6 EFC45162.1 - 0.0026 17.6 1.9 0.0032 17.4 0.2 2.0 2 0 0 2 2 2 1 TMEM154 protein family Linker_histone PF00538.19 EFC45162.1 - 0.064 13.6 0.4 3e+02 1.8 0.0 6.2 6 0 0 6 6 6 0 linker histone H1 and H5 family Ras PF00071.22 EFC45163.1 - 9.6e-20 70.8 5.1 7.8e-09 35.3 0.1 3.5 3 1 0 3 3 3 2 Ras family Roc PF08477.13 EFC45163.1 - 1.2e-07 32.0 2.0 1.6e-06 28.4 0.0 3.5 3 1 1 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC45163.1 - 0.00041 20.3 1.7 0.026 14.5 0.1 3.6 4 0 0 4 4 4 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC45163.1 - 0.00059 19.9 0.0 0.0017 18.4 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase LRR_6 PF13516.6 EFC45164.1 - 2.6e-18 64.5 12.7 0.0015 18.4 0.0 6.6 8 0 0 8 8 8 5 Leucine Rich repeat LRR_8 PF13855.6 EFC45164.1 - 6e-16 58.0 2.4 0.00022 20.9 0.0 3.9 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC45164.1 - 8.1e-12 45.2 12.3 0.011 16.2 0.3 5.5 2 1 4 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45164.1 - 4.6e-06 26.4 0.6 4.9 8.1 0.0 5.3 4 1 0 4 4 4 1 Leucine Rich Repeat F-box-like PF12937.7 EFC45164.1 - 0.033 14.1 3.0 0.04 13.8 0.7 2.1 2 0 0 2 2 2 0 F-box-like Gly_transf_sug PF04488.15 EFC45165.1 - 8.3e-10 39.2 0.5 1.6e-09 38.3 0.5 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif SPRY PF00622.28 EFC45166.1 - 0.014 15.5 0.5 0.066 13.3 0.2 2.3 2 1 0 2 2 2 0 SPRY domain 7TM_GPCR_Srab PF10292.9 EFC45166.1 - 0.18 10.7 1.0 0.27 10.1 1.0 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor Mak16 PF04874.14 EFC45167.1 - 0.71 10.5 6.7 3.3 8.4 0.0 2.6 3 0 0 3 3 3 0 Mak16 protein C-terminal region DUF16 PF01519.16 EFC45167.1 - 0.93 10.0 5.3 0.19 12.3 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF16 SBP_bac_3 PF00497.20 EFC45168.1 - 1.3e-26 93.4 0.0 3.2e-26 92.1 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan PF00060.26 EFC45168.1 - 6e-19 68.3 0.2 9.9e-19 67.6 0.2 1.4 1 0 0 1 1 1 1 Ligand-gated ion channel Lig_chan-Glu_bd PF10613.9 EFC45168.1 - 1.3e-16 60.8 0.0 2.2e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site LPAM_1 PF08139.12 EFC45169.1 - 8.7 7.1 7.3 0.66 10.6 2.4 1.8 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site NmrA PF05368.13 EFC45170.1 - 2.1e-24 86.4 0.1 2.9e-24 85.9 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC45170.1 - 1.3e-17 64.3 0.0 1.6e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC45170.1 - 8.6e-07 28.7 0.3 2e-05 24.2 0.2 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFC45170.1 - 5.4e-05 23.6 0.2 9.8e-05 22.8 0.2 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 EFC45170.1 - 8.5e-05 21.7 0.1 0.0002 20.5 0.1 1.6 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 EFC45170.1 - 0.00015 21.8 0.3 0.00031 20.8 0.3 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Shikimate_DH PF01488.20 EFC45170.1 - 0.00061 19.9 0.2 0.0011 19.0 0.2 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 EFC45170.1 - 0.0031 17.8 0.2 0.007 16.6 0.2 1.6 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_4 PF07993.12 EFC45170.1 - 0.0041 16.3 0.0 0.0061 15.8 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 EFC45170.1 - 0.0078 16.5 1.5 0.01 16.1 0.4 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFC45170.1 - 0.017 15.0 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 KR domain adh_short PF00106.25 EFC45170.1 - 0.018 14.5 0.1 0.027 13.9 0.1 1.2 1 0 0 1 1 1 0 short chain dehydrogenase VWA_2 PF13519.6 EFC45171.1 - 5e-09 36.8 0.1 1.2e-08 35.6 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC45171.1 - 5.7e-05 23.4 0.2 0.00014 22.2 0.2 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Thioredoxin_7 PF13899.6 EFC45172.1 - 3e-20 72.2 0.1 5.8e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 EFC45172.1 - 5e-12 45.4 0.5 9.7e-12 44.5 0.5 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 EFC45172.1 - 1.6e-07 31.4 0.2 2.9e-06 27.4 0.0 3.0 3 0 0 3 3 3 1 UBX domain UIM PF02809.20 EFC45172.1 - 0.0007 19.3 2.6 0.0014 18.4 2.6 1.6 1 0 0 1 1 1 1 Ubiquitin interaction motif Thioredoxin_2 PF13098.6 EFC45172.1 - 0.016 15.6 0.0 0.053 14.0 0.0 1.8 1 0 0 1 1 1 0 Thioredoxin-like domain Repressor_Mnt PF11423.8 EFC45172.1 - 5.7 6.8 4.9 6.1 6.7 0.3 2.9 3 0 0 3 3 3 0 Regulatory protein Mnt Ribosomal_L7Ae PF01248.26 EFC45173.1 - 1.8e-23 82.0 1.1 2.9e-23 81.4 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 EFC45173.1 - 0.0011 19.0 0.5 0.0058 16.7 0.5 2.0 1 1 0 1 1 1 1 RNase P subunit Pop3 Ribosomal_S21e PF01249.18 EFC45174.1 - 3.6e-34 116.7 0.3 3.9e-34 116.6 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Invasin_D3 PF09134.10 EFC45174.1 - 0.054 13.8 0.1 0.066 13.5 0.1 1.1 1 0 0 1 1 1 0 Invasin, domain 3 RNA_pol_Rpb1_5 PF04998.17 EFC45175.1 - 2.9e-71 240.0 0.1 2.9e-71 240.0 0.1 2.7 2 2 0 2 2 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 EFC45175.1 - 1.3e-56 191.4 4.4 1.2e-54 185.0 4.4 2.8 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFC45175.1 - 2.1e-28 99.2 0.1 2.2e-27 95.9 0.0 2.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 EFC45175.1 - 9.5e-19 67.9 1.8 9.5e-19 67.9 1.8 3.8 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 EFC45175.1 - 5e-18 65.0 0.6 5e-18 65.0 0.6 2.8 2 0 0 2 2 1 1 RNA polymerase Rpb1, domain 4 RNA_polI_A34 PF08208.11 EFC45175.1 - 0.0027 17.9 12.0 0.0027 17.9 12.0 2.4 2 0 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 Tub_N PF16322.5 EFC45175.1 - 0.56 10.6 16.6 0.77 10.1 10.4 2.5 2 0 0 2 2 2 0 Tubby N-terminal Rrp15p PF07890.12 EFC45175.1 - 1.5 9.1 12.1 1.9 8.8 2.9 2.9 2 0 0 2 2 2 0 Rrp15p DUF2058 PF09831.9 EFC45175.1 - 1.7 8.8 17.6 0.31 11.2 6.6 3.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2058) PDCD2_C PF04194.13 EFC45175.1 - 1.7 8.7 17.7 0.21 11.7 1.1 2.6 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain DTHCT PF08070.11 EFC45175.1 - 6.2 7.6 28.3 2.2 9.0 17.4 2.8 2 0 0 2 2 2 0 DTHCT (NUC029) region DUF913 PF06025.12 EFC45175.1 - 6.3 5.7 8.2 2.1 7.3 4.9 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Peptidase_S10 PF00450.22 EFC45176.1 - 1.6e-121 406.6 2.1 1.9e-121 406.4 2.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF2920 PF11144.8 EFC45176.1 - 3.2e-05 23.3 0.1 5.1e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2920) uDENN PF03456.18 EFC45177.1 - 0.14 13.0 0.1 0.41 11.4 0.1 1.8 1 0 0 1 1 1 0 uDENN domain Methyltransf_12 PF08242.12 EFC45178.1 - 6.8e-08 33.2 0.0 3.2e-07 31.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC45178.1 - 3.7e-06 26.9 0.0 5.7e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC45178.1 - 4.9e-05 23.2 0.1 0.00014 21.7 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC45178.1 - 0.0055 17.4 0.0 0.016 15.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 EFC45178.1 - 0.0064 16.1 0.0 0.046 13.3 0.0 2.0 1 1 0 2 2 2 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 EFC45178.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RRM_1 PF00076.22 EFC45180.1 - 2.9e-14 52.6 0.3 1.2e-09 37.9 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mitofilin PF09731.9 EFC45180.1 - 0.0026 16.7 24.2 0.0035 16.3 24.2 1.3 1 0 0 1 1 1 1 Mitochondrial inner membrane protein RRM_5 PF13893.6 EFC45180.1 - 0.017 14.7 0.6 9.7 5.8 0.1 3.2 2 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC45180.1 - 0.3 11.2 2.4 0.88 9.7 0.1 3.0 3 2 0 3 3 3 0 RNA recognition motif Nop14 PF04147.12 EFC45180.1 - 3.3 5.8 43.5 5.3 5.1 43.5 1.2 1 0 0 1 1 1 0 Nop14-like family Peptidase_S10 PF00450.22 EFC45181.1 - 1.1e-69 235.8 0.0 6.2e-69 233.4 0.0 2.1 1 1 1 2 2 2 1 Serine carboxypeptidase EGF_2 PF07974.13 EFC45181.1 - 3.4e-05 24.1 11.7 7.3e-05 23.1 11.7 1.6 1 0 0 1 1 1 1 EGF-like domain EGF PF00008.27 EFC45181.1 - 0.071 13.4 9.6 0.16 12.3 9.6 1.6 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFC45181.1 - 0.17 12.0 2.3 0.43 10.7 2.3 1.7 1 0 0 1 1 1 0 Tenascin EGF domain I-EGF_1 PF18372.1 EFC45181.1 - 0.7 10.0 9.1 1.7 8.8 9.1 1.7 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 EB PF01683.18 EFC45181.1 - 1.7 9.0 12.0 0.89 9.9 7.5 2.3 2 0 0 2 2 2 0 EB module Laminin_EGF PF00053.24 EFC45181.1 - 3.3 7.9 10.6 8 6.7 10.6 1.6 1 0 0 1 1 1 0 Laminin EGF domain DUF4476 PF14771.6 EFC45182.1 - 0.018 15.3 3.1 0.59 10.5 0.1 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4476) S4_2 PF13275.6 EFC45183.1 - 0.34 10.8 1.4 0.85 9.5 1.4 1.6 1 0 0 1 1 1 0 S4 domain RIO1 PF01163.22 EFC45185.1 - 9e-12 45.0 0.1 1.5e-11 44.2 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Pkinase PF00069.25 EFC45185.1 - 1.4e-11 44.2 0.9 1.4e-11 44.2 0.9 1.3 2 0 0 2 2 2 1 Protein kinase domain Kdo PF06293.14 EFC45185.1 - 5.7e-11 42.2 0.1 8.8e-11 41.5 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 EFC45185.1 - 5.6e-10 38.9 0.4 8.1e-10 38.4 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC45185.1 - 1.4e-05 25.2 0.0 0.00021 21.3 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFC45185.1 - 0.00038 19.9 0.0 0.00052 19.4 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EFC45185.1 - 0.0034 16.3 0.3 0.0052 15.7 0.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EFC45185.1 - 0.028 14.0 0.1 0.056 13.0 0.1 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase PI3_PI4_kinase PF00454.27 EFC45185.1 - 0.068 13.0 0.3 0.16 11.8 0.1 1.6 1 1 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase Enolase_N PF03952.16 EFC45185.1 - 0.11 12.7 0.1 0.38 10.9 0.0 2.0 2 0 0 2 2 2 0 Enolase, N-terminal domain UFC1 PF08694.11 EFC45186.1 - 1.7e-80 268.1 0.6 1.9e-80 267.9 0.6 1.0 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 UQ_con PF00179.26 EFC45186.1 - 0.023 14.3 0.9 0.046 13.4 0.9 1.6 1 1 0 1 1 1 0 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC45186.1 - 0.036 14.4 0.0 0.047 14.0 0.0 1.3 1 0 0 1 1 1 0 RWD domain DNTTIP1_dimer PF18192.1 EFC45187.1 - 0.64 10.4 4.0 1.6 9.2 1.1 2.9 2 1 0 2 2 2 0 DNTTIP1 dimerisation domain ECH_2 PF16113.5 EFC45188.1 - 9.7e-110 367.2 0.0 1.1e-109 367.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFC45188.1 - 9.3e-31 107.0 0.0 7.1e-30 104.1 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase PriX PF18689.1 EFC45188.1 - 0.15 12.4 0.0 0.45 10.9 0.0 1.8 1 0 0 1 1 1 0 Primase X RGS PF00615.19 EFC45189.1 - 6.6e-08 32.8 3.2 6.6e-08 32.8 3.2 2.5 2 1 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC45189.1 - 0.00043 20.0 1.8 0.0012 18.6 1.5 1.9 1 1 0 1 1 1 1 Regulator of G protein signalling-like domain EGF_2 PF07974.13 EFC45190.1 - 3e-07 30.7 63.4 0.00021 21.6 5.6 6.1 7 0 0 7 7 7 4 EGF-like domain RGS PF00615.19 EFC45191.1 - 2.9e-06 27.5 4.4 6.6e-06 26.4 4.4 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain SPRY PF00622.28 EFC45192.1 - 3e-20 72.5 7.2 6.2e-05 23.1 0.1 4.4 4 0 0 4 4 4 4 SPRY domain Gal-bind_lectin PF00337.22 EFC45192.1 - 0.084 12.4 0.0 3.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Galactoside-binding lectin SWIM PF04434.17 EFC45193.1 - 2.7e-06 26.9 0.2 2.7e-06 26.9 0.2 1.7 2 0 0 2 2 2 1 SWIM zinc finger zf-RING_2 PF13639.6 EFC45193.1 - 0.00023 21.4 12.7 0.00023 21.4 12.7 2.0 2 0 0 2 2 2 1 Ring finger domain FYVE_2 PF02318.16 EFC45193.1 - 0.0024 18.1 2.0 0.0053 17.0 2.0 1.5 1 0 0 1 1 1 1 FYVE-type zinc finger baeRF_family12 PF18856.1 EFC45193.1 - 0.086 13.4 0.1 0.44 11.1 0.1 2.1 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 Prok-RING_1 PF14446.6 EFC45193.1 - 0.12 12.4 13.8 0.18 11.8 6.9 2.7 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 PRP21_like_P PF12230.8 EFC45193.1 - 0.15 11.9 5.5 0.12 12.2 2.6 2.1 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein C1_1 PF00130.22 EFC45193.1 - 0.25 11.2 9.9 0.75 9.7 9.9 1.9 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_UBOX PF13445.6 EFC45193.1 - 1.1 9.4 9.6 3.1 7.9 9.6 1.9 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EFC45193.1 - 1.7 8.6 11.7 4.5 7.2 11.7 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC45193.1 - 3.3 7.6 10.1 14 5.6 10.2 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1768 PF08719.11 EFC45194.1 - 6.8e-07 29.7 0.1 1.3e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Peptidase_C1 PF00112.23 EFC45195.1 - 2.3e-52 178.2 1.3 2.6e-52 178.1 1.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC45195.1 - 0.024 13.4 0.1 0.024 13.4 0.1 1.6 2 0 0 2 2 2 0 Peptidase C1-like family LRR_8 PF13855.6 EFC45196.1 - 1e-10 41.2 7.2 0.00035 20.3 6.0 3.9 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFC45196.1 - 1e-07 32.1 19.6 4.7e-05 23.7 3.7 5.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC45196.1 - 0.0053 16.7 6.9 27 5.1 0.3 5.0 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 EFC45196.1 - 7.3 7.6 18.8 14 6.7 0.4 6.5 5 1 0 5 5 5 0 Leucine Rich Repeat RhoGEF67_u2 PF16614.5 EFC45198.1 - 0.049 13.7 0.0 0.055 13.6 0.0 1.1 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 NHL PF01436.21 EFC45199.1 - 4.8e-19 67.4 3.8 0.00011 22.0 0.0 9.6 10 0 0 10 10 10 3 NHL repeat SGL PF08450.12 EFC45199.1 - 8.8e-07 28.7 2.1 0.24 11.0 0.1 6.5 4 3 0 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC45199.1 - 0.0052 16.8 0.4 14 5.6 0.0 5.0 5 1 0 6 6 6 1 Esterase-like activity of phytase NUDIX_4 PF14815.6 EFC45199.1 - 0.075 13.0 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 NUDIX domain ComGF PF15980.5 EFC45199.1 - 0.26 11.7 3.2 1.2e+02 3.1 0.1 5.7 5 1 1 6 6 6 0 Putative Competence protein ComGF DUF2207 PF09972.9 EFC45200.1 - 0.081 11.7 1.7 0.12 11.1 1.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Borrelia_REV PF03978.13 EFC45200.1 - 0.12 12.3 1.3 0.21 11.5 1.3 1.4 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein LRR19-TM PF15176.6 EFC45200.1 - 2.2 8.3 4.8 21 5.2 0.1 2.8 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain SUIM_assoc PF16619.5 EFC45202.1 - 0.038 14.1 0.0 0.15 12.2 0.0 2.2 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SlyX PF04102.12 EFC45202.1 - 1.7 9.3 6.0 0.62 10.7 0.7 3.0 3 0 0 3 3 3 0 SlyX EF-hand_7 PF13499.6 EFC45205.1 - 1.5e-17 63.8 0.1 7.4e-11 42.3 0.5 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 EFC45205.1 - 4.3e-16 59.0 0.0 3.1e-07 30.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC45205.1 - 5.3e-16 56.9 0.3 2.6e-07 29.7 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFC45205.1 - 1.6e-15 56.7 2.7 4.7e-10 39.1 0.2 3.7 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC45205.1 - 2.9e-14 51.7 0.1 1.8e-06 27.4 0.1 4.0 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 EFC45205.1 - 0.00095 18.6 1.3 0.0017 17.8 0.1 2.1 2 0 0 2 2 2 1 EF hand GPHH PF16905.5 EFC45205.1 - 0.0057 16.4 0.0 6.7 6.6 0.0 3.8 4 0 0 4 4 4 1 Voltage-dependent L-type calcium channel, IQ-associated DUF5580 PF17743.1 EFC45205.1 - 0.009 14.6 0.0 0.0097 14.5 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) EF-hand_4 PF12763.7 EFC45205.1 - 0.024 14.6 0.0 1.1 9.3 0.0 2.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand DUF2757 PF10955.8 EFC45205.1 - 0.03 14.6 0.0 0.068 13.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) DUF592 PF04574.13 EFC45205.1 - 0.18 11.6 0.0 0.21 11.4 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF592) BTB PF00651.31 EFC45206.1 - 0.01 16.1 0.6 0.022 15.0 0.3 1.8 1 1 0 1 1 1 1 BTB/POZ domain TFIIA PF03153.13 EFC45208.1 - 0.77 9.7 10.0 1 9.2 10.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAD_binding_4 PF01565.23 EFC45210.1 - 1.8e-25 89.3 0.1 2.9e-25 88.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFC45210.1 - 3.4e-17 62.3 4.1 1.8e-16 60.0 4.7 2.0 2 0 0 2 2 2 1 Berberine and berberine like SnoaL_2 PF12680.7 EFC45210.1 - 0.045 14.4 0.0 0.2 12.3 0.0 2.1 2 0 0 2 2 2 0 SnoaL-like domain Ras PF00071.22 EFC45211.1 - 3.7e-39 133.9 0.0 4.3e-39 133.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45211.1 - 4.7e-16 59.1 0.0 6.8e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45211.1 - 0.00027 20.4 0.0 0.00044 19.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family LRR_8 PF13855.6 EFC45212.1 - 2.9e-13 49.4 26.8 2.2e-06 27.4 1.3 6.7 3 2 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 EFC45212.1 - 1.6e-10 41.0 45.7 0.00014 22.2 1.2 10.4 3 3 10 13 13 13 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC45212.1 - 0.0002 21.2 23.4 0.023 14.7 0.2 7.4 8 0 0 8 8 8 2 Leucine Rich repeat LRR_9 PF14580.6 EFC45212.1 - 0.00037 20.1 0.3 0.00037 20.1 0.3 3.3 1 1 1 3 3 3 1 Leucine-rich repeat LRR_1 PF00560.33 EFC45212.1 - 0.00084 19.6 26.7 2.4 9.0 0.2 8.1 9 1 0 9 9 9 4 Leucine Rich Repeat NUP214 PF16755.5 EFC45212.1 - 0.51 9.5 7.8 0.42 9.8 5.9 1.6 1 1 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 HALZ PF02183.18 EFC45213.1 - 0.00024 21.3 8.0 0.00024 21.3 8.0 2.3 1 1 1 2 2 2 2 Homeobox associated leucine zipper NRBF2 PF08961.10 EFC45213.1 - 0.0038 16.8 9.6 0.26 10.9 9.6 2.6 1 1 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator Ribosomal_S6 PF01250.17 EFC45213.1 - 0.082 13.2 1.0 0.26 11.6 0.2 2.3 2 0 0 2 2 2 0 Ribosomal protein S6 bZIP_2 PF07716.15 EFC45213.1 - 0.22 11.6 4.5 1.4 9.1 2.3 2.8 1 1 1 2 2 2 0 Basic region leucine zipper DUF2205 PF10224.9 EFC45213.1 - 0.31 11.1 10.3 1.9 8.5 6.1 2.9 1 1 0 2 2 2 0 Short coiled-coil protein Rootletin PF15035.6 EFC45213.1 - 0.44 10.5 8.3 0.96 9.4 8.1 1.7 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion TSC22 PF01166.18 EFC45213.1 - 0.55 10.6 8.9 0.42 11.0 1.9 3.7 1 1 3 4 4 4 0 TSC-22/dip/bun family bZIP_1 PF00170.21 EFC45213.1 - 0.75 9.9 15.0 0.15 12.1 2.8 3.1 2 1 1 3 3 3 0 bZIP transcription factor DivIC PF04977.15 EFC45213.1 - 0.91 9.3 10.4 0.21 11.3 0.9 3.2 2 1 1 3 3 3 0 Septum formation initiator Cep57_CLD_2 PF14197.6 EFC45213.1 - 0.93 9.6 6.2 4 7.6 6.2 2.2 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 CASP_C PF08172.12 EFC45213.1 - 0.95 8.7 10.3 0.099 12.0 5.8 1.6 2 0 0 2 2 2 0 CASP C terminal Csm1_N PF18504.1 EFC45213.1 - 1.2 9.5 10.5 0.58 10.5 3.8 3.4 1 1 2 3 3 3 0 Csm1 N-terminal domain DIOX_N PF14226.6 EFC45214.1 - 1.5e-05 25.7 0.1 3.4e-05 24.6 0.1 1.7 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 EFC45214.1 - 0.0012 19.3 0.0 0.0022 18.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily IU_nuc_hydro PF01156.19 EFC45215.1 - 1.3e-32 113.6 0.0 1.5e-32 113.4 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase MOZART2 PF12926.7 EFC45215.1 - 0.037 13.6 2.0 0.055 13.1 0.1 2.2 3 0 0 3 3 3 0 Mitotic-spindle organizing gamma-tubulin ring associated DNA_ligase_A_M PF01068.21 EFC45216.1 - 2.4e-42 144.9 0.0 4.9e-42 143.9 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 EFC45216.1 - 3.8e-36 125.0 1.4 8.7e-36 123.8 1.4 1.6 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 EFC45216.1 - 2.6e-16 59.8 0.7 1.4e-06 28.6 0.0 3.3 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 EFC45216.1 - 9.6e-14 51.8 0.0 3.1e-13 50.2 0.0 2.0 1 1 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 EFC45216.1 - 1.1e-10 41.8 4.5 1.3e-07 31.9 0.1 3.4 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RNA_ligase PF09414.10 EFC45216.1 - 7.6e-07 29.6 0.1 2.5e-06 27.9 0.1 2.0 1 0 0 1 1 1 1 RNA ligase LIG3_BRCT PF16759.5 EFC45216.1 - 8.3e-05 22.8 0.1 0.00034 20.8 0.0 2.2 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain mRNA_cap_enzyme PF01331.19 EFC45216.1 - 0.00025 20.9 0.3 0.01 15.7 0.3 2.6 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain PTCB-BRCT PF12738.7 EFC45216.1 - 0.002 18.1 0.4 0.018 15.0 0.0 2.7 3 0 0 3 3 3 1 twin BRCT domain BRCT_3 PF18428.1 EFC45216.1 - 0.0028 17.7 0.2 5.1 7.2 0.0 3.3 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain CDC45 PF02724.14 EFC45216.1 - 7.6 4.7 12.1 15 3.7 12.1 1.4 1 0 0 1 1 1 0 CDC45-like protein Exo_endo_phos PF03372.23 EFC45217.1 - 1.1e-09 38.2 0.0 1.2e-08 34.8 0.0 2.5 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF4488 PF14869.6 EFC45217.1 - 0.14 12.1 0.1 0.4 10.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) RGS PF00615.19 EFC45218.1 - 4.2e-14 52.8 0.1 2.1e-13 50.6 0.1 2.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain HAMP PF00672.25 EFC45218.1 - 1.1e-07 32.1 0.4 2.5e-07 31.0 0.4 1.6 1 0 0 1 1 1 1 HAMP domain CHASE4 PF05228.13 EFC45218.1 - 6.2e-05 23.2 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 CHASE4 domain Herpes_UL73 PF03554.13 EFC45218.1 - 0.0033 17.4 3.1 0.072 13.1 0.2 2.9 2 0 0 2 2 2 1 UL73 viral envelope glycoprotein cobW PF02492.19 EFC45218.1 - 0.15 11.7 0.9 0.27 10.8 0.1 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 EFC45219.1 - 5.9e-08 33.1 0.0 2.2e-07 31.2 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFC45219.1 - 5e-05 23.3 0.4 0.011 15.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFC45219.1 - 0.00097 19.7 0.0 0.0025 18.3 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 EFC45219.1 - 0.0014 18.2 0.0 0.0025 17.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 EFC45219.1 - 0.0014 18.6 1.5 0.049 13.6 0.1 3.0 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFC45219.1 - 0.0019 18.6 0.0 0.0057 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFC45219.1 - 0.0027 17.7 0.0 0.011 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EFC45219.1 - 0.0034 17.1 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFC45219.1 - 0.0037 17.7 0.0 0.011 16.2 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFC45219.1 - 0.0043 17.4 0.0 0.023 15.1 0.0 2.3 2 0 0 2 2 2 1 RNA helicase NTPase_1 PF03266.15 EFC45219.1 - 0.0071 16.3 0.1 1.2 9.0 0.0 2.8 3 0 0 3 3 3 1 NTPase AAA_33 PF13671.6 EFC45219.1 - 0.01 16.0 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 EFC45219.1 - 0.029 14.1 0.0 1.3 8.7 0.0 2.8 1 1 1 2 2 2 0 Thymidylate kinase RsgA_GTPase PF03193.16 EFC45219.1 - 0.03 14.2 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 EFC45219.1 - 0.036 13.2 0.0 0.086 12.0 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.17 EFC45219.1 - 0.06 13.4 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFC45219.1 - 0.064 13.2 0.0 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 NACHT domain HlyIII PF03006.20 EFC45219.1 - 0.069 12.8 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Haemolysin-III related T2SSE PF00437.20 EFC45219.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein PRANC PF09372.10 EFC45220.1 - 1.6 9.1 9.6 0.23 11.8 0.4 4.1 4 1 0 4 4 4 0 PRANC domain GGACT PF06094.12 EFC45221.1 - 6.1e-19 68.8 0.1 7.9e-19 68.4 0.1 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 EFC45221.1 - 0.00072 19.9 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 AIG2-like family Ank_2 PF12796.7 EFC45222.1 - 3e-06 27.7 0.0 7.4e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC45222.1 - 7.9e-05 22.9 0.0 0.00066 19.9 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) DUF4262 PF14081.6 EFC45222.1 - 0.0004 20.6 0.0 0.00092 19.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4262) Ank PF00023.30 EFC45222.1 - 0.016 15.6 0.0 0.17 12.4 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 EFC45222.1 - 0.13 12.9 0.0 1.2 9.9 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat adh_short PF00106.25 EFC45223.1 - 2.4e-09 36.9 1.9 2.2e-07 30.6 1.0 3.1 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 EFC45223.1 - 0.00082 19.3 0.5 0.0034 17.3 0.2 2.1 2 1 0 2 2 2 1 KR domain Epimerase PF01370.21 EFC45223.1 - 0.0011 18.4 0.2 0.0041 16.6 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC45223.1 - 0.0022 17.2 2.2 0.0066 15.6 0.7 2.4 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 EFC45223.1 - 0.018 14.8 0.1 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Blt1 PF12754.7 EFC45224.1 - 0.1 12.9 0.5 0.22 11.8 0.5 1.5 1 0 0 1 1 1 0 Blt1 N-terminal domain Sorting_nexin PF03700.13 EFC45224.1 - 1.9 9.0 9.6 6.5 7.3 9.0 1.9 1 1 1 2 2 2 0 Sorting nexin, N-terminal domain HCO3_cotransp PF00955.21 EFC45225.1 - 3.6e-111 372.5 24.7 1.1e-55 189.4 9.1 2.5 1 1 1 2 2 2 2 HCO3- transporter family DDDD PF10161.9 EFC45225.1 - 3.4 7.5 4.9 10 5.9 0.2 3.1 3 0 0 3 3 3 0 Putative mitochondrial precursor protein MazG-like PF12643.7 EFC45226.1 - 6.9e-10 39.0 0.1 9.3e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 MazG-like family MazG PF03819.17 EFC45226.1 - 1.2e-07 31.8 0.1 2e-07 31.1 0.1 1.4 1 1 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain dUTPase_2 PF08761.11 EFC45226.1 - 0.016 15.4 0.4 0.031 14.5 0.4 1.5 1 1 0 1 1 1 0 dUTPase PRA-PH PF01503.17 EFC45226.1 - 0.067 13.6 0.0 0.085 13.3 0.0 1.3 1 1 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase Peptidase_M8 PF01457.16 EFC45227.1 - 6.8e-67 226.3 0.0 7.7e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Leishmanolysin HEPN_Swt1 PF18731.1 EFC45228.1 - 1.2 9.5 4.7 2.6 8.4 0.5 3.2 3 0 0 3 3 3 0 Swt1-like HEPN ABC_tran_CTD PF16326.5 EFC45228.1 - 3.1 8.1 9.2 2 8.8 5.0 3.1 3 0 0 3 3 3 0 ABC transporter C-terminal domain WD40 PF00400.32 EFC45229.1 - 2.4e-32 110.4 17.8 0.00081 20.2 0.1 11.1 11 1 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC45229.1 - 6.4e-14 52.0 0.0 5.4e-06 26.6 0.0 6.5 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 EFC45229.1 - 2.1e-10 40.3 0.0 6e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 HELP motif WD40_like PF17005.5 EFC45229.1 - 0.00037 19.9 3.2 1.6 8.0 0.1 4.6 3 2 0 5 5 5 2 WD40-like domain PD40 PF07676.12 EFC45229.1 - 0.034 14.1 2.1 14 5.7 0.0 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 EFC45229.1 - 0.077 11.9 0.1 3.5 6.5 0.0 3.3 2 2 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Mito_fiss_reg PF05308.11 EFC45230.1 - 0.0017 18.5 17.3 0.0017 18.5 17.3 2.6 1 1 1 2 2 2 1 Mitochondrial fission regulator YcbB PF08664.10 EFC45230.1 - 0.12 12.4 2.2 7.6 6.6 0.3 2.6 2 0 0 2 2 2 0 YcbB domain Ribosomal_L29 PF00831.23 EFC45230.1 - 0.12 12.3 1.9 3.4 7.7 0.7 2.7 2 0 0 2 2 2 0 Ribosomal L29 protein MBOAT PF03062.19 EFC45231.1 - 1.5e-33 116.6 21.3 1.5e-33 116.6 21.3 1.7 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family YABBY PF04690.13 EFC45232.1 - 0.074 13.6 1.4 0.25 11.9 1.4 1.9 1 1 0 1 1 1 0 YABBY protein FERM_F2 PF18377.1 EFC45232.1 - 0.11 12.4 2.3 0.3 11.0 0.2 2.6 2 1 1 3 3 3 0 FERM F2 acyl-CoA binding protein-like domain Pkinase PF00069.25 EFC45233.1 - 3.2e-35 121.8 0.1 3.5e-35 121.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45233.1 - 1.4e-31 109.7 0.0 1.6e-31 109.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45233.1 - 1.1e-07 31.1 0.1 1.2e-07 30.9 0.1 1.0 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC45233.1 - 0.00055 19.0 0.0 0.00077 18.5 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC45233.1 - 0.0024 17.8 0.0 0.0028 17.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC45233.1 - 0.0038 16.6 0.0 0.0042 16.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 EFC45235.1 - 5.1e-56 190.0 4.5 5.7e-56 189.8 4.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45235.1 - 7e-35 120.6 0.5 9e-35 120.2 0.5 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45235.1 - 7.8e-08 31.5 0.1 1.7e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC45235.1 - 0.0001 21.8 0.3 0.00019 20.9 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 EFC45235.1 - 0.00011 21.8 0.3 0.00027 20.5 0.3 1.6 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL AceK PF06315.11 EFC45235.1 - 0.012 14.1 0.3 0.019 13.4 0.3 1.2 1 0 0 1 1 1 0 Isocitrate dehydrogenase kinase/phosphatase (AceK) RIO1 PF01163.22 EFC45235.1 - 0.017 14.7 0.6 0.017 14.7 0.6 1.6 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 EFC45235.1 - 0.036 14.0 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 EFC45236.1 - 1.4e-49 168.9 0.1 8.2e-49 166.3 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45236.1 - 9.1e-42 143.1 0.2 1.4e-40 139.2 0.2 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC45236.1 - 1.7e-15 56.1 12.5 9.2e-06 25.4 0.1 9.8 11 0 0 11 11 11 3 NHL repeat EGF_2 PF07974.13 EFC45236.1 - 4.4e-10 39.7 57.5 0.009 16.4 12.1 4.6 4 0 0 4 4 4 4 EGF-like domain Haspin_kinase PF12330.8 EFC45236.1 - 0.028 13.3 0.1 0.061 12.2 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 EFC45236.1 - 0.065 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Reg_prop PF07494.11 EFC45236.1 - 0.29 11.5 2.3 13 6.4 0.1 4.2 3 0 0 3 3 3 0 Two component regulator propeller EGF PF00008.27 EFC45236.1 - 6.6 7.1 33.0 5.2 7.5 3.3 4.8 4 0 0 4 4 4 0 EGF-like domain G8 PF10162.9 EFC45237.1 - 5e-15 55.7 0.0 1.2e-14 54.4 0.0 1.7 1 0 0 1 1 1 1 G8 domain CHRD PF07452.12 EFC45237.1 - 0.0051 17.8 0.1 0.018 16.0 0.0 2.0 2 0 0 2 2 2 1 CHRD domain SH3_19 PF18597.1 EFC45237.1 - 0.15 11.9 0.1 0.41 10.5 0.1 1.7 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain ubiquitin PF00240.23 EFC45238.1 - 2.2e-36 123.4 6.4 1.8e-21 75.6 1.5 2.8 2 1 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC45238.1 - 2.4e-15 56.1 3.2 6.6e-09 35.5 0.5 2.9 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC45238.1 - 0.00076 19.9 0.3 0.061 13.8 0.3 2.5 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC45238.1 - 0.013 15.5 0.0 1.6 8.7 0.0 2.2 1 1 1 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC45238.1 - 0.013 15.6 0.0 0.058 13.5 0.0 2.0 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFC45238.1 - 0.023 14.7 1.0 3 7.9 0.1 2.9 2 1 1 3 3 3 0 Ubiquitin-like domain DUF3861 PF12977.7 EFC45238.1 - 0.13 12.5 0.1 0.55 10.4 0.0 1.9 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) DUF608 PF04685.13 EFC45239.1 - 3.6e-122 408.0 2.9 3.6e-122 408.0 2.9 1.5 2 0 0 2 2 2 1 Glycosyl-hydrolase family 116, catalytic region Glyco_hydr_116N PF12215.8 EFC45239.1 - 6.5e-55 186.8 2.9 1.1e-54 186.1 2.9 1.3 1 0 0 1 1 1 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term DUF1079 PF06435.11 EFC45240.1 - 0.041 14.1 2.2 0.091 13.0 2.2 1.6 1 0 0 1 1 1 0 Repeat of unknown function (DUF1079) Serpin PF00079.20 EFC45241.1 - 0.066 12.5 0.0 0.076 12.3 0.0 1.0 1 0 0 1 1 1 0 Serpin (serine protease inhibitor) SIR2 PF02146.17 EFC45242.1 - 5.8e-28 98.0 0.4 3.1e-23 82.6 0.1 2.3 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 EFC45242.1 - 0.0021 17.8 0.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Goodbye PF17109.5 EFC45242.1 - 0.046 14.2 0.1 0.1 13.1 0.1 1.5 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain Peptidase_C1 PF00112.23 EFC45243.1 - 4.2e-52 177.4 5.9 4.8e-52 177.2 5.9 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC45243.1 - 2.6e-06 26.5 1.5 0.035 12.9 0.1 2.1 2 0 0 2 2 2 2 Peptidase C1-like family FAD_binding_4 PF01565.23 EFC45244.1 - 2.9e-15 56.2 0.6 4.8e-15 55.5 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 EFC45244.1 - 5.3e-10 39.2 0.7 4.8e-09 36.2 0.3 2.8 3 0 0 3 3 3 1 Berberine and berberine like PFO_beta_C PF12367.8 EFC45244.1 - 0.045 13.9 0.4 0.15 12.3 0.4 1.8 1 0 0 1 1 1 0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal PLATZ PF04640.14 EFC45244.1 - 0.14 12.8 0.2 9.4 6.9 0.1 2.6 2 0 0 2 2 2 0 PLATZ transcription factor EGF_2 PF07974.13 EFC45245.1 - 4.3e-11 43.0 16.6 2.9e-05 24.3 2.6 2.5 2 0 0 2 2 2 2 EGF-like domain GPS PF01825.21 EFC45245.1 - 0.0012 19.4 0.0 0.0037 17.8 0.0 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_Tenascin PF18720.1 EFC45245.1 - 0.0014 18.7 2.5 0.0014 18.7 2.5 2.4 2 0 0 2 2 2 1 Tenascin EGF domain EGF PF00008.27 EFC45245.1 - 0.0014 18.9 15.5 0.0091 16.3 3.4 2.7 2 0 0 2 2 2 2 EGF-like domain hEGF PF12661.7 EFC45245.1 - 0.0049 17.4 17.6 0.032 14.9 5.8 3.0 2 0 0 2 2 2 2 Human growth factor-like EGF SIT PF15330.6 EFC45245.1 - 0.03 14.8 0.5 0.094 13.2 0.1 2.0 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT EGF_alliinase PF04863.13 EFC45245.1 - 0.97 9.9 17.0 0.26 11.7 2.1 2.4 1 1 1 2 2 2 0 Alliinase EGF-like domain Laminin_EGF PF00053.24 EFC45245.1 - 1.6 8.9 17.9 6 7.1 2.4 2.5 2 0 0 2 2 2 0 Laminin EGF domain I-EGF_1 PF18372.1 EFC45245.1 - 2 8.6 12.2 1.2 9.3 6.1 3.1 2 0 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 DSL PF01414.19 EFC45245.1 - 7.4 6.9 15.3 11 6.4 2.7 2.1 1 1 1 2 2 2 0 Delta serrate ligand HATPase_c PF02518.26 EFC45246.1 - 4.1e-16 59.5 0.0 9.4e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC45246.1 - 1.8e-12 47.1 0.6 4e-12 46.0 0.6 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain Wzy_C_2 PF11846.8 EFC45246.1 - 0.12 12.3 0.3 0.35 10.8 0.3 1.8 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal F-box-like PF12937.7 EFC45247.1 - 0.00032 20.5 0.1 0.00052 19.9 0.1 1.3 1 0 0 1 1 1 1 F-box-like HHH_6 PF14579.6 EFC45247.1 - 0.046 14.0 0.1 0.082 13.2 0.1 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif CCDC32 PF14989.6 EFC45247.1 - 0.16 11.9 1.7 0.17 11.9 0.2 1.7 2 0 0 2 2 2 0 Coiled-coil domain containing 32 TaqI_C PF12950.7 EFC45247.1 - 0.26 11.4 4.4 1 9.4 3.3 2.5 2 1 0 2 2 2 0 TaqI-like C-terminal specificity domain Ras PF00071.22 EFC45248.1 - 2.1e-32 112.0 0.1 2.8e-32 111.6 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45248.1 - 6e-22 78.1 0.0 9.5e-22 77.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45248.1 - 9.5e-14 51.2 0.0 1.2e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC45248.1 - 2.9e-07 30.1 0.0 3.4e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC45248.1 - 2.9e-06 26.9 0.0 0.00042 19.9 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC45248.1 - 1.8e-05 24.8 0.0 4.8e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC45248.1 - 3.1e-05 23.5 0.0 4.7e-05 22.9 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC45248.1 - 0.0022 17.2 0.2 0.0075 15.5 0.0 1.6 1 1 1 2 2 2 1 G-protein alpha subunit RsgA_GTPase PF03193.16 EFC45248.1 - 0.0031 17.4 0.0 0.075 12.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Parvo_NS1 PF01057.17 EFC45248.1 - 0.025 13.7 0.0 0.15 11.1 0.0 1.9 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PduV-EutP PF10662.9 EFC45248.1 - 0.12 12.1 0.1 0.32 10.8 0.1 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Anth_Ig PF05587.13 EFC45249.1 - 0.034 14.5 4.8 0.088 13.1 0.0 2.9 2 1 0 2 2 2 0 Anthrax receptor extracellular domain Flagellar_put PF12611.8 EFC45250.1 - 0.24 11.2 1.0 0.63 9.9 1.0 1.7 1 0 0 1 1 1 0 Putative flagellar TMEM132D_C PF15706.5 EFC45250.1 - 0.33 10.8 1.6 0.66 9.8 1.6 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term WD40 PF00400.32 EFC45251.1 - 8.2e-49 162.6 14.1 1.3e-08 35.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC45251.1 - 1.2e-16 60.7 0.0 0.0048 17.2 0.0 6.1 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC45251.1 - 3.8e-09 36.0 0.0 0.00022 20.3 0.0 4.5 4 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC45251.1 - 0.00062 19.2 0.4 2.3 7.5 0.0 3.4 4 0 0 4 4 4 2 WD40-like domain PD40 PF07676.12 EFC45251.1 - 0.097 12.6 0.2 3.1 7.8 0.0 3.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EFC45251.1 - 0.14 10.6 0.3 12 4.3 0.1 2.4 1 1 1 2 2 2 0 Cytochrome D1 heme domain Ras PF00071.22 EFC45252.1 - 8.9e-33 113.2 2.0 7e-32 110.3 2.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC45252.1 - 1.1e-21 77.2 1.2 1.5e-19 70.4 1.2 2.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45252.1 - 2.3e-07 30.4 0.1 1.9e-05 24.2 0.1 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC45252.1 - 0.021 14.9 0.0 0.041 14.0 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_trans_N PF14510.6 EFC45252.1 - 0.1 13.2 0.2 5.2 7.7 0.0 3.0 3 0 0 3 3 3 0 ABC-transporter N-terminal TniB PF05621.11 EFC45252.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein PTS_IIB PF02302.17 EFC45252.1 - 0.12 13.1 0.3 3.2 8.5 0.0 2.8 3 0 0 3 3 3 0 PTS system, Lactose/Cellobiose specific IIB subunit TB2_DP1_HVA22 PF03134.19 EFC45253.1 - 5.1e-30 103.2 5.3 9.5e-30 102.4 5.3 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family GtrA PF04138.14 EFC45253.1 - 0.00034 20.8 1.0 0.0006 20.0 1.0 1.4 1 0 0 1 1 1 1 GtrA-like protein Chlorosome_CsmC PF11098.8 EFC45253.1 - 0.048 13.6 0.0 0.082 12.9 0.0 1.2 1 0 0 1 1 1 0 Chlorosome envelope protein C EF-hand_1 PF00036.32 EFC45254.1 - 1.6e-08 33.5 8.4 0.00011 21.4 0.7 3.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFC45254.1 - 1.2e-06 28.0 8.4 0.0021 17.9 0.2 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 EFC45254.1 - 1.8e-06 28.3 1.0 1.8e-06 28.3 1.0 2.4 3 1 0 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC45254.1 - 0.00021 21.6 0.5 0.77 10.1 0.1 2.7 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 EFC45254.1 - 0.00058 19.2 5.1 0.042 13.3 0.5 2.9 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC45254.1 - 0.019 14.8 0.3 0.019 14.8 0.3 2.5 2 0 0 2 2 2 0 EF-hand domain pair Terminase_6C PF17289.2 EFC45254.1 - 0.052 13.6 0.1 0.15 12.2 0.1 1.7 1 0 0 1 1 1 0 Terminase RNaseH-like domain Pkinase_Tyr PF07714.17 EFC45255.1 - 2.6e-52 177.7 0.6 7.8e-51 172.8 0.6 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC45255.1 - 2.3e-51 174.7 0.3 2.8e-51 174.4 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC45255.1 - 5.1e-05 22.2 0.0 8.9e-05 21.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC45255.1 - 0.0053 16.1 0.0 0.0086 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like LRR_6 PF13516.6 EFC45256.1 - 1.1e-27 93.7 9.2 0.00061 19.6 0.0 10.1 10 1 1 11 11 11 6 Leucine Rich repeat LRR_8 PF13855.6 EFC45256.1 - 6e-19 67.6 16.6 6.6e-07 29.0 0.5 5.7 3 2 3 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC45256.1 - 1.3e-14 54.1 27.4 0.00098 19.5 0.0 7.8 1 1 7 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45256.1 - 4.7e-08 32.5 10.9 4.2 8.3 0.0 9.4 12 0 0 12 12 12 2 Leucine Rich Repeat F-box-like PF12937.7 EFC45256.1 - 0.0034 17.2 1.8 0.01 15.7 0.2 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC45256.1 - 0.46 10.4 2.3 5.7 6.9 0.2 3.0 2 1 0 2 2 2 0 F-box domain Ras PF00071.22 EFC45257.1 - 1.4e-36 125.5 2.9 2.7e-36 124.6 2.9 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45257.1 - 5.2e-18 65.4 0.1 1.4e-17 64.1 0.1 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45257.1 - 2.4e-14 53.2 0.4 4.2e-14 52.4 0.4 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC45257.1 - 9.5e-05 21.9 1.4 0.0002 20.9 1.4 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC45257.1 - 0.00013 22.1 0.1 0.00034 20.7 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC45257.1 - 0.00025 20.7 1.3 0.00045 19.8 0.0 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 EFC45257.1 - 0.0072 16.3 1.6 0.0072 16.3 1.6 2.0 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA PF00004.29 EFC45257.1 - 0.03 14.8 0.4 0.13 12.7 0.4 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EFC45257.1 - 0.073 12.5 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 EFC45257.1 - 0.1 12.1 0.1 0.28 10.7 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EFC45257.1 - 0.15 12.1 2.2 0.28 11.2 1.4 1.9 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain NOG1 PF06858.14 EFC45257.1 - 0.45 10.3 2.4 1.6 8.6 0.9 2.6 2 1 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) HRG PF16954.5 EFC45258.1 - 0.032 14.6 0.0 0.032 14.6 0.0 3.9 4 0 0 4 4 4 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Neur_chan_memb PF02932.16 EFC45258.1 - 0.09 12.8 0.1 0.09 12.8 0.1 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region OppC_N PF12911.7 EFC45258.1 - 7.7 6.6 0.0 7.7 6.6 0.0 3.7 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C Epimerase PF01370.21 EFC45259.1 - 1.5e-12 47.5 0.0 2e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC45259.1 - 2.3e-09 37.1 0.0 1.1e-05 25.0 0.0 2.4 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC45259.1 - 0.002 17.2 0.0 0.015 14.3 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 EFC45259.1 - 0.0022 17.9 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC45259.1 - 0.015 14.9 0.1 0.087 12.4 0.1 1.9 2 0 0 2 2 2 0 NmrA-like family DapB_N PF01113.20 EFC45259.1 - 0.064 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 EFC45259.1 - 0.1 11.7 0.0 1.4 8.0 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain KdgM PF06178.13 EFC45259.1 - 0.13 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Oligogalacturonate-specific porin protein (KdgM) LRR_6 PF13516.6 EFC45260.1 - 4.5e-32 107.4 27.5 1.5e-06 27.8 0.9 8.5 8 0 0 8 8 8 8 Leucine Rich repeat PH PF00169.29 EFC45260.1 - 5.9e-14 52.5 1.9 9.9e-12 45.3 1.9 2.4 1 1 0 1 1 1 1 PH domain LRR_1 PF00560.33 EFC45260.1 - 4.7e-05 23.4 10.9 17 6.4 0.0 7.9 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_4 PF12799.7 EFC45260.1 - 5e-05 23.6 21.3 0.23 11.9 0.3 5.5 1 1 5 6 6 6 5 Leucine Rich repeats (2 copies) PH_11 PF15413.6 EFC45260.1 - 0.00051 20.4 5.0 0.0083 16.5 5.0 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFC45260.1 - 0.0066 16.7 0.7 0.017 15.4 0.3 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 EFC45260.1 - 0.13 12.6 0.1 5 7.5 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain LRR_8 PF13855.6 EFC45260.1 - 0.14 11.9 18.8 0.31 10.8 6.6 5.4 2 2 3 5 5 5 0 Leucine rich repeat TPT PF03151.16 EFC45261.1 - 6e-10 38.9 14.7 7.3e-10 38.7 14.7 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family SPW PF03779.14 EFC45261.1 - 0.23 11.1 0.1 0.23 11.1 0.1 2.8 3 0 0 3 3 3 0 SPW repeat DUF2070 PF09843.9 EFC45261.1 - 1.1 7.5 17.5 0.17 10.1 13.9 1.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) ECH_1 PF00378.20 EFC45262.1 - 4.6e-26 91.7 0.3 8.2e-21 74.4 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC45262.1 - 2.4e-18 66.8 0.1 1.2e-15 57.8 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase dUTPase PF00692.19 EFC45263.1 - 2.8e-05 23.8 0.0 7.1e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 dUTPase DCD PF06559.11 EFC45263.1 - 0.00036 19.4 0.0 0.33 9.7 0.0 2.1 1 1 1 2 2 2 2 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Ras PF00071.22 EFC45264.1 - 3.2e-25 88.6 0.5 6.3e-25 87.7 0.2 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC45264.1 - 8.6e-10 38.9 0.0 1.5e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45264.1 - 1.3e-07 31.3 0.1 2.1e-07 30.6 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC45264.1 - 5.3e-07 29.7 0.9 9.8e-05 22.3 0.4 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 EFC45264.1 - 0.00042 20.3 2.5 0.00096 19.1 0.6 2.2 1 1 1 2 2 2 1 C-terminal region of MMR_HSR1 domain GTP_EFTU PF00009.27 EFC45264.1 - 0.0012 18.4 0.7 0.012 15.2 0.4 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFC45264.1 - 0.019 14.5 1.1 0.041 13.4 0.5 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B G-alpha PF00503.20 EFC45264.1 - 0.076 12.2 1.8 0.55 9.3 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit TIP49_C PF17856.1 EFC45264.1 - 0.11 12.7 0.0 0.34 11.1 0.0 1.8 1 0 0 1 1 1 0 TIP49 AAA-lid domain F-box-like PF12937.7 EFC45264.1 - 0.12 12.3 0.4 0.36 10.8 0.4 1.8 1 0 0 1 1 1 0 F-box-like AAA_29 PF13555.6 EFC45264.1 - 0.15 11.8 0.1 0.29 10.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 EFC45264.1 - 0.16 12.0 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC45264.1 - 0.29 10.9 3.9 0.87 9.3 0.5 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Peptidase_C34 PF05413.11 EFC45264.1 - 1.4 9.2 4.5 1.6 9.0 2.0 2.2 1 1 1 2 2 2 0 Putative closterovirus papain-like endopeptidase LRR_6 PF13516.6 EFC45265.1 - 9.6e-36 118.8 0.1 0.0023 17.8 0.0 8.9 9 0 0 9 9 9 8 Leucine Rich repeat LRR_8 PF13855.6 EFC45265.1 - 3.7e-25 87.5 2.7 3.6e-06 26.6 0.0 4.7 2 1 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC45265.1 - 1.7e-21 75.9 0.5 0.00021 21.6 0.0 5.8 1 1 5 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45265.1 - 3.3e-13 48.2 0.0 24 6.0 0.0 9.3 10 0 0 10 10 10 1 Leucine Rich Repeat Spidroin_N PF16763.5 EFC45265.1 - 0.005 16.9 8.3 69 3.5 0.0 7.4 1 1 8 9 9 9 0 Major ampullate spidroin 1, spider silk protein 1, N-term DUF4368 PF14287.6 EFC45265.1 - 0.03 14.6 13.4 2.9 8.3 0.2 5.7 4 2 2 6 6 6 0 Domain of unknown function (DUF4368) RVT_N PF13655.6 EFC45265.1 - 0.11 12.7 0.1 80 3.6 0.0 4.0 5 0 0 5 5 5 0 N-terminal domain of reverse transcriptase LPP PF04728.13 EFC45266.1 - 0.055 13.9 0.1 0.055 13.9 0.1 7.0 8 0 0 8 8 8 0 Lipoprotein leucine-zipper Trans_reg_C PF00486.28 EFC45266.1 - 0.23 11.5 2.2 0.36 10.9 0.1 2.5 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal FUSC PF04632.12 EFC45266.1 - 5.5 5.4 9.8 4.6 5.7 1.2 2.7 3 0 0 3 3 3 0 Fusaric acid resistance protein family Pox_A_type_inc PF04508.12 EFC45266.1 - 7.1 6.7 18.5 18 5.4 0.5 5.8 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat CX9C PF16860.5 EFC45267.1 - 0.0071 16.3 14.6 0.064 13.3 1.6 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 EFC45267.1 - 0.033 14.3 13.5 0.12 12.5 1.1 3.0 2 2 1 3 3 3 0 CHCH domain NDUF_B7 PF05676.13 EFC45267.1 - 0.53 10.0 13.4 0.47 10.2 2.1 2.4 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) ACBP PF00887.19 EFC45268.1 - 3.2e-32 110.6 0.4 3.5e-32 110.5 0.4 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein DUF5316 PF17247.2 EFC45269.1 - 0.15 12.1 1.0 2.6 8.1 0.4 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5316) DnaJ PF00226.31 EFC45270.1 - 2e-13 50.3 0.5 4.1e-13 49.3 0.1 1.8 2 0 0 2 2 2 1 DnaJ domain DUF226 PF02890.14 EFC45270.1 - 0.072 13.1 4.7 0.71 9.9 0.3 2.6 1 1 1 2 2 2 0 Borrelia family of unknown function DUF226 Pkinase PF00069.25 EFC45271.1 - 1.2e-72 244.5 0.0 1.3e-72 244.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45271.1 - 4.1e-31 108.2 0.0 5.2e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC45271.1 - 0.00013 21.0 0.4 0.00054 19.0 0.4 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFC45271.1 - 0.0011 18.1 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 EFC45271.1 - 0.0054 16.1 0.4 0.014 14.7 0.1 1.9 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 EFC45271.1 - 0.0086 16.0 0.1 0.016 15.1 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family DUF2854 PF11016.8 EFC45271.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) Kdo PF06293.14 EFC45271.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Syja_N PF02383.18 EFC45272.1 - 1.3e-71 241.6 7.1 4.9e-71 239.6 7.1 2.1 1 1 0 1 1 1 1 SacI homology domain DEP PF00610.21 EFC45272.1 - 4e-10 39.6 0.1 1.1e-09 38.2 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF547 PF04784.14 EFC45272.1 - 5.4e-07 29.7 0.0 2.5e-06 27.5 0.0 2.2 1 0 0 1 1 1 1 Protein of unknown function, DUF547 DUF2408 PF10303.9 EFC45272.1 - 0.023 15.3 1.0 3.5 8.2 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) Mucin PF01456.17 EFC45272.1 - 1 9.4 13.1 2.4 8.2 13.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EFC45272.1 - 3 5.9 8.5 4.5 5.4 8.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mut7-C PF01927.16 EFC45273.1 - 1.3e-25 90.2 0.1 2.7e-25 89.2 0.1 1.5 1 0 0 1 1 1 1 Mut7-C RNAse domain E7 PF00527.18 EFC45273.1 - 2.1 8.6 13.3 0.024 14.8 3.5 2.6 2 2 0 2 2 2 0 E7 protein, Early protein UQ_con PF00179.26 EFC45274.1 - 2.8e-21 75.6 0.1 5.9e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme F-box-like PF12937.7 EFC45274.1 - 0.00024 20.9 0.1 0.00049 19.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like RWD PF05773.22 EFC45274.1 - 0.00062 20.0 0.0 0.0018 18.6 0.0 1.8 1 0 0 1 1 1 1 RWD domain F-box PF00646.33 EFC45274.1 - 0.0067 16.3 0.1 0.025 14.5 0.1 1.9 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 EFC45274.1 - 0.025 14.4 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 0 F-box HNH PF01844.23 EFC45275.1 - 0.0016 18.5 1.2 0.0016 18.5 1.2 2.1 2 1 0 2 2 2 1 HNH endonuclease FERM_f0 PF16511.5 EFC45275.1 - 0.025 14.8 0.0 0.061 13.6 0.0 1.7 1 0 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM FBPase PF00316.20 EFC45275.1 - 0.041 13.4 0.2 0.06 12.8 0.2 1.2 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain TFIIA_gamma_N PF02268.16 EFC45275.1 - 0.29 11.2 3.3 15 5.7 0.2 3.1 2 1 1 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain zf-AD PF07776.15 EFC45275.1 - 0.89 9.8 5.8 0.4 11.0 0.4 2.8 2 2 1 3 3 3 0 Zinc-finger associated domain (zf-AD) UPF0139 PF03669.13 EFC45276.1 - 8.9e-20 70.4 0.2 1e-19 70.2 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) DUF4116 PF13475.6 EFC45277.1 - 1e-23 82.7 4.9 2.1e-09 37.0 0.2 4.4 2 2 0 3 3 3 3 Domain of unknown function (DUF4116) RPW8 PF05659.11 EFC45277.1 - 0.0068 16.1 0.9 0.96 9.1 0.1 2.8 3 0 0 3 3 3 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 mTERF PF02536.14 EFC45277.1 - 0.008 15.1 0.7 0.015 14.2 0.7 1.5 1 1 0 1 1 1 1 mTERF F-box PF00646.33 EFC45278.1 - 3.9e-05 23.4 0.0 0.00016 21.4 0.0 2.1 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC45278.1 - 0.095 12.6 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 F-box-like PH PF00169.29 EFC45279.1 - 4.2e-10 40.1 1.3 3.8e-07 30.6 0.1 3.4 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 EFC45279.1 - 0.00097 19.4 0.1 0.11 12.8 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_12 PF16457.5 EFC45279.1 - 0.0011 19.5 3.1 0.0018 18.8 0.3 2.5 2 1 1 3 3 3 1 Pleckstrin homology domain PH_9 PF15410.6 EFC45279.1 - 0.069 13.5 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4589 PF15252.6 EFC45279.1 - 0.15 12.0 0.1 0.15 12.0 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4589) Lactamase_B PF00753.27 EFC45280.1 - 2.6e-18 66.7 0.0 4.2e-18 66.1 0.0 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC45280.1 - 1.5e-06 27.9 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EFC45280.1 - 0.057 12.8 0.0 0.11 11.9 0.0 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain MMR_HSR1 PF01926.23 EFC45281.1 - 5.4e-16 58.7 0.0 1.1e-15 57.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC45281.1 - 8e-06 25.9 0.1 0.0018 18.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC45281.1 - 0.0012 18.4 0.1 0.35 10.4 0.0 2.5 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 EFC45281.1 - 0.0023 17.5 0.0 0.0061 16.1 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 EFC45281.1 - 0.0039 16.5 0.3 0.034 13.4 0.0 2.7 3 1 0 3 3 3 1 Septin Roc PF08477.13 EFC45281.1 - 0.03 14.5 0.0 0.09 13.0 0.0 1.9 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF3860 PF12976.7 EFC45282.1 - 0.18 11.8 3.8 0.18 11.9 0.8 2.5 2 1 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3860) WD40 PF00400.32 EFC45283.1 - 1.8e-15 57.0 8.8 0.048 14.5 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC45283.1 - 0.023 15.0 0.0 0.79 10.1 0.0 2.8 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain JAB PF01398.21 EFC45284.1 - 5.5e-31 107.0 1.5 7.1e-31 106.6 0.0 2.0 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 EFC45284.1 - 1.7e-19 70.5 2.8 1.7e-19 70.5 2.8 2.3 2 0 0 2 2 2 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 EFC45284.1 - 0.00017 21.4 0.0 0.0003 20.6 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EFC45284.1 - 0.018 15.1 0.1 0.049 13.7 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) DER1 PF04511.15 EFC45285.1 - 1.6e-51 175.0 13.1 1.9e-51 174.7 13.1 1.0 1 0 0 1 1 1 1 Der1-like family RGS PF00615.19 EFC45286.1 - 1.1e-08 35.3 2.6 3.5e-08 33.7 2.6 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC45286.1 - 0.0054 16.5 4.2 0.018 14.7 4.2 1.9 1 1 0 1 1 1 1 Regulator of G protein signalling-like domain JHD PF17811.1 EFC45286.1 - 0.13 12.8 6.2 0.19 12.3 2.1 2.8 2 0 0 2 2 2 0 Jumonji helical domain DUF1768 PF08719.11 EFC45287.1 - 6e-51 172.9 0.9 7.2e-51 172.6 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) zf-CHY PF05495.12 EFC45288.1 - 2e-10 41.0 12.5 2e-10 41.0 12.5 3.6 3 0 0 3 3 3 2 CHY zinc finger MCR PF18509.1 EFC45288.1 - 0.42 10.2 8.9 0.37 10.4 1.4 3.2 3 0 0 3 3 3 0 Magnetochrome domain PHM7_cyt PF14703.6 EFC45289.1 - 1.7e-10 41.4 0.5 3.3e-09 37.2 0.2 2.4 2 1 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 EFC45289.1 - 8.9e-07 28.5 20.9 8.9e-07 28.5 20.9 2.7 2 1 1 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate Anoctamin PF04547.12 EFC45289.1 - 5.9e-05 22.1 6.3 5.9e-05 22.1 6.3 3.5 3 2 0 3 3 3 1 Calcium-activated chloride channel Stevor PF17410.2 EFC45289.1 - 5.8 6.4 9.8 0.35 10.4 1.9 2.5 2 1 0 2 2 2 0 Subtelomeric Variable Open Reading frame Trypan_PARP PF05887.11 EFC45290.1 - 2.9e-06 27.3 80.2 0.0045 17.0 39.0 2.2 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) RGS PF00615.19 EFC45292.1 - 2.5e-09 37.4 6.1 3.9e-09 36.8 2.1 3.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain DUF489 PF04356.12 EFC45292.1 - 0.041 13.9 0.5 4.6 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF489) fn2 PF00040.19 EFC45292.1 - 0.26 11.6 1.6 0.77 10.1 1.6 1.8 1 0 0 1 1 1 0 Fibronectin type II domain DSPc PF00782.20 EFC45293.1 - 4.5e-35 120.4 1.9 7.2e-35 119.7 1.9 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC45293.1 - 4.2e-06 27.0 0.2 6.6e-06 26.3 0.2 1.4 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFC45293.1 - 0.0066 16.0 1.4 0.0095 15.5 1.4 1.6 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DUF5101 PF17031.5 EFC45293.1 - 1.2 9.2 5.4 0.61 10.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) Kazal_1 PF00050.21 EFC45294.1 - 0.0031 17.5 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 2 Kazal-type serine protease inhibitor domain Kazal_2 PF07648.15 EFC45294.1 - 0.01 15.9 0.1 2.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain DUF2481 PF10654.9 EFC45296.1 - 0.63 10.0 9.0 2.8 7.9 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2481) LapA_dom PF06305.11 EFC45297.1 - 0.001 18.8 0.0 0.002 17.9 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain CD34_antigen PF06365.12 EFC45297.1 - 0.004 16.8 0.0 0.0053 16.4 0.0 1.1 1 0 0 1 1 1 1 CD34/Podocalyxin family Phage_holin_2_4 PF16082.5 EFC45297.1 - 0.0053 16.5 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 Bacteriophage holin family, superfamily II-like DUF2371 PF10177.9 EFC45297.1 - 0.012 15.8 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) DUF4381 PF14316.6 EFC45297.1 - 0.023 14.9 0.2 0.064 13.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Pilin_N PF07790.11 EFC45297.1 - 0.025 15.5 0.0 4.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal DUF202 PF02656.15 EFC45297.1 - 0.029 14.8 0.2 0.048 14.1 0.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF202) PspB PF06667.12 EFC45297.1 - 0.047 13.7 0.0 0.078 13.0 0.0 1.3 1 0 0 1 1 1 0 Phage shock protein B HlyIII PF03006.20 EFC45297.1 - 0.066 12.9 0.1 0.068 12.9 0.1 1.1 1 0 0 1 1 1 0 Haemolysin-III related EphA2_TM PF14575.6 EFC45297.1 - 0.13 13.1 0.2 0.47 11.4 0.0 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Gram_pos_anchor PF00746.21 EFC45297.1 - 0.16 11.9 2.7 0.92 9.5 0.1 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF2207 PF09972.9 EFC45297.1 - 0.79 8.4 2.7 1.9 7.1 3.1 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Pollen_allerg_1 PF01357.21 EFC45298.1 - 6.9e-07 29.2 0.0 1.9e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 Pollen allergen DPBB_1 PF03330.18 EFC45298.1 - 0.0016 18.7 0.0 0.0038 17.5 0.0 1.6 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 EFC45298.1 - 0.016 15.0 0.1 0.04 13.8 0.1 1.7 1 0 0 1 1 1 0 Barwin family Peptidase_C78 PF07910.13 EFC45299.1 - 4.6e-17 62.2 0.3 1.1e-16 61.0 0.3 1.6 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C54 PF03416.19 EFC45299.1 - 0.021 14.3 0.0 0.05 13.0 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C54 DUF4473 PF14747.6 EFC45299.1 - 0.37 11.4 5.2 5.1 7.7 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4473) YABBY PF04690.13 EFC45300.1 - 1.8e-11 44.9 7.6 4e-11 43.7 5.0 2.5 1 1 1 2 2 2 1 YABBY protein CALCOCO1 PF07888.11 EFC45300.1 - 0.011 14.6 0.3 0.016 14.1 0.3 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HMG_box_2 PF09011.10 EFC45300.1 - 0.02 15.5 0.3 0.02 15.5 0.3 1.9 2 0 0 2 2 2 0 HMG-box domain Hydrolase_4 PF12146.8 EFC45301.1 - 7.8e-07 28.6 0.0 9.2e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PhoPQ_related PF10142.9 EFC45301.1 - 0.0001 21.1 0.1 0.00013 20.8 0.1 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Abhydrolase_1 PF00561.20 EFC45301.1 - 0.0029 17.3 0.0 0.0029 17.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 EFC45301.1 - 0.042 13.6 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family FSH1 PF03959.13 EFC45301.1 - 0.057 13.1 0.0 0.075 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DLH PF01738.18 EFC45301.1 - 0.086 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family KRTDAP PF15200.6 EFC45301.1 - 0.096 12.5 0.3 0.22 11.3 0.3 1.6 1 0 0 1 1 1 0 Keratinocyte differentiation-associated FAD_binding_4 PF01565.23 EFC45302.1 - 5.4e-20 71.6 0.0 2.2e-19 69.6 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 EFC45302.1 - 0.00014 21.6 0.1 0.0021 17.7 0.0 2.7 2 1 0 2 2 2 1 FAD linked oxidases, C-terminal domain HSM3_N PF18795.1 EFC45302.1 - 0.085 12.3 0.1 0.2 11.1 0.1 1.6 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, N terminal domain Poxvirus_B22R PF04395.12 EFC45302.1 - 0.1 12.2 0.3 0.28 10.7 0.3 1.8 1 0 0 1 1 1 0 Poxvirus B22R protein KH_1 PF00013.29 EFC45303.1 - 4e-06 26.6 0.3 8.3e-06 25.5 0.3 1.6 1 0 0 1 1 1 1 KH domain DUF481 PF04338.12 EFC45303.1 - 0.06 13.3 0.2 0.06 13.3 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF481 KH_2 PF07650.17 EFC45303.1 - 0.097 12.5 0.2 0.27 11.1 0.2 1.7 1 0 0 1 1 1 0 KH domain PmrD PF11183.8 EFC45303.1 - 0.17 12.0 1.5 3 8.0 0.0 3.1 3 0 0 3 3 3 0 Polymyxin resistance protein PmrD Presenilin PF01080.17 EFC45303.1 - 8.4 5.0 9.5 1.2 7.8 4.6 1.9 2 0 0 2 2 2 0 Presenilin GPS PF01825.21 EFC45304.1 - 4.6e-06 27.1 0.1 1.4e-05 25.6 0.1 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC45304.1 - 0.083 13.3 4.5 0.097 13.1 1.1 2.3 2 0 0 2 2 2 0 EGF-like domain DUF4199 PF13858.6 EFC45304.1 - 0.27 11.6 0.1 0.27 11.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) zf-C3HC PF07967.13 EFC45305.1 - 1.3e-17 64.1 0.9 1.3e-17 64.1 0.9 2.5 2 0 0 2 2 2 1 C3HC zinc finger-like YokU PF14122.6 EFC45305.1 - 3.4 7.7 7.0 1.5 8.9 0.3 3.6 3 1 1 4 4 4 0 YokU-like protein, putative antitoxin EF-hand_1 PF00036.32 EFC45307.1 - 1.8e-11 42.7 1.7 1e-05 24.7 0.1 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC45307.1 - 2.7e-11 43.8 0.6 4.2e-11 43.1 0.6 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC45307.1 - 1.6e-10 40.0 0.2 4.2e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFC45307.1 - 1.7e-10 39.9 1.2 2.8e-05 23.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC45307.1 - 5.5e-08 32.5 0.2 0.00024 20.9 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC45307.1 - 8.9e-06 26.0 0.9 0.018 15.3 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EFC45307.1 - 0.074 12.9 0.4 0.35 10.8 0.0 2.0 2 0 0 2 2 2 0 EF hand GPS PF01825.21 EFC45308.1 - 1.8e-06 28.3 0.1 5.6e-06 26.8 0.1 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC45308.1 - 0.14 12.6 5.1 0.43 11.0 5.1 1.8 1 0 0 1 1 1 0 EGF-like domain DUF5074 PF16819.5 EFC45308.1 - 1.1 9.3 13.3 7 6.7 1.2 5.2 4 1 1 5 5 5 0 Domain of unknown function (DUF5074) DUF4769 PF15992.5 EFC45308.1 - 4.8 6.9 5.5 12 5.6 5.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) Podoplanin PF05808.11 EFC45308.1 - 7.9 6.6 12.6 0.032 14.3 1.3 2.3 2 0 0 2 2 2 0 Podoplanin zf-MYND PF01753.18 EFC45311.1 - 1.8e-08 34.3 16.6 1.8e-08 34.3 16.6 2.2 2 0 0 2 2 2 1 MYND finger DUF2397 PF09660.10 EFC45311.1 - 0.12 11.2 0.2 0.16 10.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) zf-HIT PF04438.16 EFC45311.1 - 0.91 9.4 11.1 2.4 8.1 11.1 1.8 1 0 0 1 1 1 0 HIT zinc finger F-box PF00646.33 EFC45313.1 - 7.1e-09 35.3 0.0 2e-08 33.9 0.0 1.8 1 0 0 1 1 1 1 F-box domain XPA_C PF05181.12 EFC45313.1 - 0.0007 19.5 0.7 0.0015 18.4 0.1 1.9 2 0 0 2 2 2 1 XPA protein C-terminus F-box-like PF12937.7 EFC45313.1 - 0.0013 18.6 0.3 0.0043 16.9 0.0 2.1 2 0 0 2 2 2 1 F-box-like ORC6 PF05460.13 EFC45313.1 - 0.0062 15.9 4.1 0.0092 15.3 4.1 1.3 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) DUF908 PF06012.12 EFC45313.1 - 0.22 10.9 5.1 0.46 9.8 5.1 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Presenilin PF01080.17 EFC45313.1 - 0.3 9.8 3.0 0.48 9.1 3.0 1.3 1 0 0 1 1 1 0 Presenilin Nucleo_P87 PF07267.11 EFC45313.1 - 0.39 9.5 11.9 0.4 9.5 10.7 1.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 YhfH PF14149.6 EFC45313.1 - 0.9 9.6 5.3 16 5.6 0.7 2.8 2 0 0 2 2 2 0 YhfH-like protein CDC45 PF02724.14 EFC45313.1 - 1.6 7.0 10.8 2.2 6.5 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein RP-C_C PF11800.8 EFC45313.1 - 4.9 7.2 6.2 16 5.5 3.8 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region SIR2 PF02146.17 EFC45314.1 - 6.6e-28 97.8 3.9 6.5e-22 78.3 1.3 2.3 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 EFC45314.1 - 6.2e-05 22.8 0.1 0.29 10.8 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain X PF00739.19 EFC45314.1 - 0.18 11.9 0.7 0.32 11.1 0.7 1.4 1 0 0 1 1 1 0 Trans-activation protein X RAP1 PF07218.11 EFC45314.1 - 1.6 6.9 12.1 7.2 4.7 10.3 2.1 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) p450 PF00067.22 EFC45315.1 - 1.4e-78 264.8 1.3 1.6e-78 264.5 1.3 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ras PF00071.22 EFC45316.1 - 2e-23 82.8 0.0 2.4e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45316.1 - 1.8e-09 37.9 0.0 2.9e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 EFC45316.1 - 0.026 14.3 0.2 4.8 6.9 0.1 3.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF45 PF01863.17 EFC45317.1 - 0.0035 17.4 1.5 0.0075 16.3 1.5 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF45 tRNA_anti-codon PF01336.25 EFC45318.1 - 0.063 13.3 0.0 0.2 11.7 0.0 1.9 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Hexokinase_2 PF03727.16 EFC45318.1 - 0.084 12.3 6.5 1.1 8.6 1.0 2.5 2 0 0 2 2 2 0 Hexokinase tRNA-synt_2b PF00587.25 EFC45319.1 - 8.3e-35 120.4 0.0 1.7e-34 119.4 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFC45319.1 - 2.8e-19 69.3 5.6 1.3e-18 67.2 0.7 2.4 1 1 0 2 2 2 2 Seryl-tRNA synthetase N-terminal domain LIN52 PF10044.9 EFC45320.1 - 0.037 14.7 0.1 0.53 11.0 0.0 2.8 2 0 0 2 2 2 0 Retinal tissue protein NuA4 PF09340.10 EFC45320.1 - 0.056 13.3 0.0 0.18 11.7 0.0 1.8 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 MKT1_C PF12246.8 EFC45321.1 - 0.012 14.9 0.2 0.027 13.7 0.2 1.6 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication F-box-like PF12937.7 EFC45321.1 - 0.13 12.2 1.1 0.28 11.1 1.1 1.6 1 0 0 1 1 1 0 F-box-like SnoaL_2 PF12680.7 EFC45324.1 - 0.00021 21.9 0.0 0.00028 21.5 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 EFC45324.1 - 0.0046 17.5 0.0 0.0049 17.4 0.0 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain SnoaL_4 PF13577.6 EFC45324.1 - 0.086 13.0 0.0 0.094 12.8 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF3130 PF11328.8 EFC45325.1 - 0.15 12.3 0.2 0.52 10.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3130 Tim17 PF02466.19 EFC45328.1 - 8.7e-15 55.1 0.3 1.9e-14 54.0 0.3 1.6 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF1525 PF07511.11 EFC45328.1 - 0.2 11.8 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Exo_endo_phos PF03372.23 EFC45329.1 - 6e-21 75.0 0.0 1.8e-20 73.4 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family AAA_22 PF13401.6 EFC45330.1 - 0.00075 19.8 0.0 0.0016 18.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFC45330.1 - 0.03 14.3 0.1 1.5 8.7 0.0 3.3 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea DAG_kinase_N PF14513.6 EFC45330.1 - 0.071 13.3 0.1 0.24 11.6 0.1 1.9 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus AAA_16 PF13191.6 EFC45330.1 - 0.15 12.5 0.0 0.47 10.8 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain PI3Ka PF00613.20 EFC45331.1 - 1.6e-55 187.4 3.5 2.9e-55 186.6 3.5 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 EFC45331.1 - 1.7e-46 159.0 2.2 7.7e-46 156.9 0.5 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 EFC45331.1 - 1.8e-15 57.1 0.0 5.4e-15 55.5 0.0 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 C2 PF00168.30 EFC45331.1 - 0.0037 17.5 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF2090 PF09863.9 EFC45331.1 - 0.028 13.5 0.2 0.099 11.7 0.0 1.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2090) POPLD PF08170.12 EFC45332.1 - 0.18 12.2 0.0 0.42 11.0 0.0 1.6 1 0 0 1 1 1 0 POPLD (NUC188) domain Lig_C PF18330.1 EFC45333.1 - 0.0035 17.4 0.9 1.7 8.7 0.0 3.1 2 1 1 3 3 3 2 Ligase Pab1020 C-terminal region R-HINP1I PF11463.8 EFC45333.1 - 0.019 14.4 0.4 0.019 14.4 0.4 2.2 2 0 0 2 2 2 0 R.HinP1I restriction endonuclease DUF3510 PF12022.8 EFC45334.1 - 0.11 12.9 4.2 0.27 11.6 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) PUF PF00806.19 EFC45335.1 - 6.1e-20 69.7 7.6 0.00033 20.2 0.0 7.2 6 2 1 7 7 7 5 Pumilio-family RNA binding repeat DUF3683 PF12447.8 EFC45335.1 - 0.045 13.9 1.9 0.85 9.8 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3683) AcetylCoA_hyd_C PF13336.6 EFC45336.1 - 7.4e-61 204.6 0.1 1.1e-60 204.1 0.1 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 EFC45336.1 - 5.4e-19 69.0 0.0 1.6e-18 67.4 0.0 1.7 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain DeoRC PF00455.22 EFC45336.1 - 0.064 13.2 0.0 0.45 10.4 0.0 2.1 2 0 0 2 2 2 0 DeoR C terminal sensor domain AAA_2 PF07724.14 EFC45337.1 - 4.2e-54 183.2 0.3 1.7e-51 174.7 0.0 3.5 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 EFC45337.1 - 2.6e-32 110.8 2.9 2.6e-32 110.8 2.9 3.7 1 1 2 3 3 3 1 AAA lid domain AAA PF00004.29 EFC45337.1 - 9e-25 87.6 0.2 1.1e-10 42.1 0.0 3.6 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 EFC45337.1 - 5.6e-24 84.0 0.5 6.6e-23 80.6 0.1 3.2 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 EFC45337.1 - 4.7e-15 55.8 0.8 8.3e-11 42.0 0.0 3.7 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC45337.1 - 3.1e-10 40.7 6.7 0.00017 22.0 0.1 5.0 5 1 1 6 6 4 2 AAA ATPase domain Sigma54_activat PF00158.26 EFC45337.1 - 9.5e-10 38.4 0.2 6.8e-07 29.1 0.0 3.3 3 1 0 3 3 3 1 Sigma-54 interaction domain AAA_14 PF13173.6 EFC45337.1 - 3e-08 33.8 0.0 0.00072 19.6 0.0 3.1 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EFC45337.1 - 5.2e-08 32.8 0.0 0.0017 18.1 0.0 2.9 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.6 EFC45337.1 - 2.9e-07 30.8 6.3 0.009 16.3 0.0 5.3 5 2 0 5 5 4 2 AAA domain NACHT PF05729.12 EFC45337.1 - 5.2e-07 29.7 0.5 0.096 12.6 0.0 3.4 3 0 0 3 3 3 2 NACHT domain TniB PF05621.11 EFC45337.1 - 3.9e-06 26.4 0.0 0.0024 17.3 0.0 3.7 2 1 0 2 2 2 1 Bacterial TniB protein RuvB_N PF05496.12 EFC45337.1 - 3e-05 23.8 0.3 0.27 11.0 0.0 3.9 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain Clp_N PF02861.20 EFC45337.1 - 8.6e-05 22.6 0.2 0.064 13.4 0.4 2.9 2 0 0 2 2 2 1 Clp amino terminal domain, pathogenicity island component DUF815 PF05673.13 EFC45337.1 - 0.00021 20.5 0.6 0.2 10.8 0.3 3.1 2 1 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 EFC45337.1 - 0.00027 20.5 0.0 0.032 13.7 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 EFC45337.1 - 0.00027 20.6 0.6 0.2 11.2 0.0 4.1 4 1 0 4 4 4 1 AAA domain Torsin PF06309.11 EFC45337.1 - 0.0005 20.2 0.0 0.0031 17.6 0.0 2.3 2 0 0 2 2 2 1 Torsin RNA_helicase PF00910.22 EFC45337.1 - 0.0005 20.4 0.1 1.2 9.5 0.0 3.6 4 0 0 4 4 2 1 RNA helicase Mg_chelatase PF01078.21 EFC45337.1 - 0.0016 17.9 0.0 2.5 7.4 0.0 3.3 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFC45337.1 - 0.0019 18.0 0.0 0.044 13.6 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 EFC45337.1 - 0.0063 16.3 1.2 1.3 8.7 0.0 3.5 4 0 0 4 4 3 1 AAA domain Roc PF08477.13 EFC45337.1 - 0.01 16.0 0.0 0.31 11.3 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC45337.1 - 0.011 15.7 5.7 1.3 8.9 0.0 3.5 3 1 1 4 4 4 0 RsgA GTPase AAA_33 PF13671.6 EFC45337.1 - 0.013 15.7 0.0 0.25 11.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 EFC45337.1 - 0.032 14.2 2.0 0.85 9.6 0.0 3.8 5 1 0 5 5 2 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 EFC45337.1 - 0.078 13.5 4.7 0.82 10.2 0.0 3.7 3 1 0 3 3 3 0 ABC transporter TsaE PF02367.17 EFC45337.1 - 0.099 12.6 0.0 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFC45337.1 - 0.1 13.2 9.0 7.3 7.1 0.2 5.4 4 2 2 6 6 5 0 AAA domain DUF87 PF01935.17 EFC45337.1 - 0.16 12.0 0.0 0.16 12.0 0.0 4.3 4 1 0 4 4 3 0 Helicase HerA, central domain DUF3500 PF12006.8 EFC45337.1 - 0.22 11.0 1.6 0.56 9.6 1.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3500) AAA_23 PF13476.6 EFC45337.1 - 0.56 10.7 0.0 0.56 10.7 0.0 4.0 3 1 0 3 3 1 0 AAA domain UPF0242 PF06785.11 EFC45337.1 - 1.1 9.3 18.1 3.7 7.6 18.1 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus EMP24_GP25L PF01105.24 EFC45337.1 - 3.8 7.4 8.7 1.5 8.8 4.8 2.3 2 0 0 2 2 1 0 emp24/gp25L/p24 family/GOLD Methyltransf_32 PF13679.6 EFC45337.1 - 8.8 6.3 9.8 42 4.1 0.0 4.5 4 1 0 4 4 3 0 Methyltransferase domain Pkinase PF00069.25 EFC45338.1 - 1.4e-37 129.6 1.4 1.5e-37 129.4 1.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45338.1 - 4.2e-37 127.8 0.6 4.5e-37 127.7 0.6 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC45338.1 - 1.5e-05 24.1 0.6 1.8e-05 23.9 0.6 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC45338.1 - 0.0091 15.9 0.0 0.052 13.5 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC45338.1 - 0.036 12.8 0.1 0.034 12.9 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 EFC45338.1 - 0.042 13.4 0.4 0.43 10.1 0.1 2.1 2 0 0 2 2 2 0 RIO1 family 5_nucleotid_C PF02872.18 EFC45339.1 - 2.6e-37 128.5 0.0 4.3e-37 127.8 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 EFC45339.1 - 1.5e-07 32.1 0.1 3e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ras PF00071.22 EFC45340.1 - 1.7e-24 86.3 0.1 8.3e-20 71.0 0.0 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC45340.1 - 4.8e-13 49.4 0.1 2.3e-08 34.3 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC45340.1 - 0.00022 21.2 0.5 0.0062 16.5 0.1 3.0 2 1 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC45340.1 - 0.0018 18.4 0.0 0.0048 17.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EFC45340.1 - 0.0072 16.1 0.0 2.2 8.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain GTP_EFTU PF00009.27 EFC45340.1 - 0.0079 15.7 0.0 0.015 14.9 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.18 EFC45340.1 - 0.0081 15.5 0.3 0.48 9.6 0.3 2.4 1 1 0 1 1 1 1 Septin AAA_22 PF13401.6 EFC45340.1 - 0.015 15.6 0.0 0.047 14.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain AIG1 PF04548.16 EFC45340.1 - 0.044 13.1 0.1 2.3 7.5 0.0 2.8 2 1 0 2 2 2 0 AIG1 family AAA_16 PF13191.6 EFC45340.1 - 0.055 13.8 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain MCM PF00493.23 EFC45340.1 - 0.064 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain ABC_tran PF00005.27 EFC45340.1 - 0.093 13.2 0.1 0.47 11.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_5 PF07728.14 EFC45340.1 - 0.13 12.3 0.0 0.38 10.8 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) Dynamin_N PF00350.23 EFC45340.1 - 0.7 9.9 4.2 1 9.4 1.3 2.4 2 1 0 2 2 1 0 Dynamin family DUF3446 PF11928.8 EFC45340.1 - 1.7 9.0 10.3 0.36 11.2 6.0 2.0 2 0 0 2 2 2 0 Early growth response N-terminal domain Serpin PF00079.20 EFC45342.1 - 4.2e-34 118.5 0.4 4.5e-34 118.3 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) LRR_4 PF12799.7 EFC45343.1 - 5e-10 39.5 19.3 4.3e-06 27.0 2.9 3.3 2 1 2 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45343.1 - 2.1e-06 27.4 7.8 6.6e-06 25.8 7.8 2.0 1 0 0 1 1 1 1 Leucine rich repeat LRR_9 PF14580.6 EFC45343.1 - 6.4e-06 25.8 0.8 1.4e-05 24.7 0.8 1.5 1 0 0 1 1 1 1 Leucine-rich repeat GPI-anchored PF10342.9 EFC45344.1 - 0.017 15.9 1.0 0.035 14.9 0.4 1.9 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family LigB PF02900.18 EFC45345.1 - 3.5e-38 131.3 0.0 4.1e-38 131.0 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase LytR_C PF13399.6 EFC45345.1 - 0.11 13.5 0.0 0.29 12.1 0.0 1.8 1 1 1 2 2 2 0 LytR cell envelope-related transcriptional attenuator SPOR PF05036.13 EFC45345.1 - 0.14 12.5 0.2 0.37 11.2 0.0 1.7 2 0 0 2 2 2 0 Sporulation related domain RGS PF00615.19 EFC45346.1 - 1.4e-06 28.6 1.0 1.4e-06 28.6 1.0 2.4 2 1 0 2 2 2 1 Regulator of G protein signaling domain Synaptobrevin PF00957.21 EFC45346.1 - 2.4 8.0 8.6 0.72 9.7 0.3 3.0 2 0 0 2 2 2 0 Synaptobrevin Arf PF00025.21 EFC45348.1 - 8.6e-62 207.7 0.0 9.6e-62 207.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC45348.1 - 1e-12 48.3 0.0 1.4e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC45348.1 - 1.1e-11 44.6 0.0 1.4e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFC45348.1 - 6.5e-10 38.7 0.0 8.3e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC45348.1 - 7.4e-10 38.5 0.4 4.5e-07 29.4 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC45348.1 - 7.7e-09 35.2 0.0 9.7e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC45348.1 - 5.6e-06 26.4 0.0 8.4e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 EFC45348.1 - 0.027 13.5 0.0 0.042 12.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB OB_RNB PF08206.11 EFC45349.1 - 0.066 12.9 0.1 0.14 11.8 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain Tankyrase_bdg_C PF15327.6 EFC45349.1 - 0.65 10.4 8.6 0.075 13.5 2.6 2.0 2 0 0 2 2 2 0 Tankyrase binding protein C terminal domain RabGAP-TBC PF00566.18 EFC45351.1 - 8.4e-18 64.8 10.9 1e-14 54.7 5.0 2.4 1 1 0 2 2 2 2 Rab-GTPase-TBC domain Sdh5 PF03937.16 EFC45351.1 - 0.028 14.4 0.8 0.064 13.2 0.1 2.0 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase Tcf25 PF04910.14 EFC45352.1 - 2.8e-51 174.7 2.9 6e-51 173.6 2.9 1.4 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_12 PF13424.6 EFC45352.1 - 0.00054 20.2 1.9 2 8.7 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC45352.1 - 0.057 12.8 2.7 0.17 11.2 0.6 2.1 2 0 0 2 2 2 0 MalT-like TPR region TPR_2 PF07719.17 EFC45352.1 - 0.071 13.3 0.2 0.61 10.3 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC45352.1 - 0.13 12.9 0.3 2.6 8.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Pardaxin PF07425.11 EFC45352.1 - 0.15 11.7 0.7 0.44 10.2 0.7 1.8 1 0 0 1 1 1 0 Pardaxin LRR_8 PF13855.6 EFC45353.1 - 0.031 14.0 0.4 0.062 13.1 0.4 1.4 1 0 0 1 1 1 0 Leucine rich repeat Copine PF07002.16 EFC45354.1 - 1.1e-72 244.1 0.1 1.7e-72 243.4 0.1 1.3 1 0 0 1 1 1 1 Copine C2 PF00168.30 EFC45354.1 - 1.2e-25 89.7 0.0 7.5e-12 45.4 0.0 2.3 2 0 0 2 2 2 2 C2 domain vWA-TerF-like PF10138.9 EFC45354.1 - 0.00039 20.6 0.0 0.0018 18.4 0.0 1.9 2 0 0 2 2 2 1 vWA found in TerF C terminus Guanylate_cyc PF00211.20 EFC45355.1 - 0.012 15.2 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain DUF3160 PF11369.8 EFC45356.1 - 4.5e-59 200.5 3.3 1.4e-49 169.1 0.3 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3160) INCENP_ARK-bind PF03941.15 EFC45357.1 - 5.1e-18 64.8 2.6 5.9e-18 64.6 0.1 2.5 2 0 0 2 2 2 1 Inner centromere protein, ARK binding region GNAT_acetyltr_2 PF13718.6 EFC45357.1 - 1.4 8.3 6.2 1.8 7.9 4.5 2.1 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Ureide_permease PF07168.11 EFC45357.1 - 2.9 6.5 6.4 5.4 5.7 6.4 1.3 1 0 0 1 1 1 0 Ureide permease HECT PF00632.25 EFC45358.1 - 1.8e-98 329.8 0.1 2.1e-98 329.6 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) ARID PF01388.21 EFC45359.1 - 2.2e-11 44.3 0.2 8.4e-11 42.4 0.3 2.0 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Cyclophil_like PF04126.13 EFC45359.1 - 9.4e-07 28.7 0.0 2.1e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin-like Il13Ra_Ig PF18001.1 EFC45359.1 - 0.021 14.9 0.3 0.052 13.6 0.3 1.6 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain OmpH PF03938.14 EFC45359.1 - 0.11 12.9 2.4 0.2 12.0 2.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2652 PF10851.8 EFC45360.1 - 0.0012 19.0 4.8 0.1 12.7 0.7 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF2652) FYVE PF01363.21 EFC45360.1 - 0.009 16.1 12.7 0.009 16.1 12.7 2.0 2 1 0 2 2 2 1 FYVE zinc finger FlxA PF14282.6 EFC45360.1 - 0.13 12.2 9.9 0.75 9.8 0.5 3.4 2 1 1 3 3 3 0 FlxA-like protein LPP PF04728.13 EFC45360.1 - 0.31 11.5 10.2 1.3 9.5 0.0 4.7 4 2 1 5 5 5 0 Lipoprotein leucine-zipper TolA_bind_tri PF16331.5 EFC45360.1 - 2.1 8.5 6.0 3.8 7.7 0.8 3.3 3 1 1 4 4 4 0 TolA binding protein trimerisation ERM PF00769.19 EFC45360.1 - 3.7 7.3 15.0 0.89 9.3 6.3 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family PRP38 PF03371.15 EFC45362.1 - 4e-36 124.5 1.0 6.8e-36 123.7 1.0 1.3 1 0 0 1 1 1 1 PRP38 family 7tm_7 PF08395.12 EFC45364.1 - 0.0079 15.4 5.5 0.0095 15.2 5.5 1.1 1 0 0 1 1 1 1 7tm Chemosensory receptor DUF4199 PF13858.6 EFC45364.1 - 1.9 8.9 13.2 0.21 12.0 7.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) GFA PF04828.14 EFC45365.1 - 4.2e-07 30.2 1.9 4.2e-07 30.2 1.9 1.7 2 1 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Guanylate_cyc PF00211.20 EFC45367.1 - 2.4e-05 24.1 0.1 5.5e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain F-box PF00646.33 EFC45368.1 - 8.9e-05 22.3 0.2 0.00037 20.3 0.2 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC45368.1 - 0.00012 21.9 0.1 0.00035 20.4 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFC45368.1 - 0.15 12.6 35.8 1.2 9.7 2.7 8.1 3 3 2 7 7 7 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45368.1 - 6.6 6.6 24.9 0.75 9.6 1.0 6.4 7 2 1 8 8 8 0 Leucine rich repeat LRR_6 PF13516.6 EFC45368.1 - 9.4 6.6 11.1 3.2 8.0 0.1 5.2 6 0 0 6 6 6 0 Leucine Rich repeat Pentapeptide PF00805.22 EFC45369.1 - 5.8e-26 89.7 20.3 1.2e-07 31.2 0.1 5.0 4 2 2 6 6 6 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 EFC45369.1 - 2e-16 59.9 10.4 5.6e-10 39.2 1.0 3.3 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC45369.1 - 2.7e-14 53.3 0.0 5.9e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide_3 PF13576.6 EFC45369.1 - 6.3e-14 51.9 11.4 6e-07 29.5 0.8 4.2 3 1 0 3 3 3 2 Pentapeptide repeats (9 copies) BTB_3 PF16017.5 EFC45369.1 - 0.0011 19.1 0.0 0.0031 17.6 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain CfAFP PF05264.11 EFC45369.1 - 0.093 12.7 2.1 1.8 8.6 1.2 2.2 1 1 1 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) Ribonuclease_T2 PF00445.18 EFC45370.1 - 7e-08 32.9 1.0 1e-07 32.4 1.0 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family Thioredoxin_4 PF13462.6 EFC45370.1 - 0.043 14.0 0.1 0.091 12.9 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin DUF5392 PF17370.2 EFC45370.1 - 0.12 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5392) F-box-like PF12937.7 EFC45371.1 - 2.2e-05 24.2 0.1 7.6e-05 22.5 0.1 1.9 1 0 0 1 1 1 1 F-box-like HBD PF18534.1 EFC45371.1 - 0.055 13.6 0.0 0.22 11.7 0.0 2.0 1 0 0 1 1 1 0 Helical bundle domain Protoglobin PF11563.8 EFC45372.1 - 3.3e-46 157.1 0.2 3.8e-46 156.9 0.2 1.1 1 0 0 1 1 1 1 Protoglobin UPF0242 PF06785.11 EFC45373.1 - 0.055 13.6 0.3 0.055 13.6 0.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Deltameth_res PF16020.5 EFC45373.1 - 2.3 8.2 4.2 28 4.7 0.7 3.1 2 0 0 2 2 2 0 Deltamethrin resistance Zw10 PF06248.13 EFC45374.1 - 1.1e-12 47.4 0.5 3.4e-12 45.7 0.1 1.8 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 EFC45374.1 - 7e-05 22.6 4.4 0.00014 21.7 4.4 1.5 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal RFX_DNA_binding PF02257.15 EFC45374.1 - 0.058 14.0 0.3 1.4 9.6 0.0 2.8 2 1 0 2 2 2 0 RFX DNA-binding domain Vac_Fusion PF02346.16 EFC45374.1 - 0.35 10.5 1.7 0.99 9.1 0.1 2.6 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 ATP-synt_C PF00137.21 EFC45375.1 - 5.5e-33 113.1 33.8 6.9e-20 71.2 11.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C DUF4064 PF13273.6 EFC45375.1 - 0.74 10.1 13.2 0.23 11.7 9.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) MIS13 PF08202.11 EFC45376.1 - 0.0074 15.6 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family Prenyltrans PF00432.21 EFC45377.1 - 7.9e-21 73.5 12.4 1.4e-05 24.7 0.0 6.7 7 1 0 7 7 7 5 Prenyltransferase and squalene oxidase repeat IQ PF00612.27 EFC45378.1 - 7.4e-21 71.9 25.4 0.00014 21.4 0.4 8.0 7 0 0 7 7 7 6 IQ calmodulin-binding motif DUF1623 PF07785.11 EFC45378.1 - 0.12 12.6 0.5 4 7.7 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1623) ArfGap PF01412.18 EFC45379.1 - 2.1e-25 89.1 0.1 3.3e-25 88.4 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DUF1201 PF06716.11 EFC45379.1 - 0.0093 16.0 0.2 0.015 15.3 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1201) EF-hand_6 PF13405.6 EFC45380.1 - 0.022 14.7 0.3 0.56 10.3 0.1 3.2 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 EFC45380.1 - 0.13 11.8 0.7 1.7 8.3 0.1 3.2 2 1 1 3 3 3 0 EF hand XG_FTase PF03254.13 EFC45381.1 - 3.5e-07 29.2 7.3 2.1e-06 26.6 7.3 2.2 1 1 0 1 1 1 1 Xyloglucan fucosyltransferase PQ-loop PF04193.14 EFC45382.1 - 2.6e-32 110.4 13.1 7.1e-17 60.9 3.2 2.8 2 0 0 2 2 2 2 PQ loop repeat MMM1 PF10296.9 EFC45382.1 - 0.012 14.6 0.5 0.019 14.1 0.5 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 MscL PF01741.18 EFC45382.1 - 0.06 13.6 1.1 0.11 12.8 0.2 2.1 1 1 1 2 2 2 0 Large-conductance mechanosensitive channel, MscL SSXRD PF09514.10 EFC45382.1 - 0.41 10.3 1.7 0.89 9.2 1.7 1.6 1 0 0 1 1 1 0 SSXRD motif Homeobox_KN PF05920.11 EFC45383.1 - 1.3e-12 47.4 3.1 2.2e-12 46.7 0.7 2.5 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFC45383.1 - 3.5e-05 23.5 4.4 8.2e-05 22.4 3.6 2.1 1 1 0 1 1 1 1 Homeodomain DUF4116 PF13475.6 EFC45384.1 - 1.7e-110 360.6 1.3 1.6e-18 66.1 0.0 8.1 6 1 0 7 7 7 7 Domain of unknown function (DUF4116) Staph_haemo PF05480.11 EFC45384.1 - 0.014 15.2 4.2 17 5.3 0.0 6.2 8 0 0 8 8 8 0 Staphylococcus haemolytic protein Bac_DnaA_C PF08299.11 EFC45384.1 - 0.072 13.1 0.1 16 5.6 0.0 4.2 5 0 0 5 5 5 0 Bacterial dnaA protein helix-turn-helix CAS_CSE1 PF03378.15 EFC45385.1 - 1.5e-117 392.8 8.0 4.5e-117 391.2 8.0 1.8 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 EFC45385.1 - 3.8e-72 243.2 5.7 1.1e-71 241.7 5.7 1.8 1 0 0 1 1 1 1 Cse1 Xpo1 PF08389.12 EFC45385.1 - 3e-07 30.6 2.3 3e-07 30.6 2.3 4.1 3 1 1 4 4 4 1 Exportin 1-like protein IBN_N PF03810.19 EFC45385.1 - 3.5e-07 30.1 0.1 1.9e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Sulfate_transp PF00916.20 EFC45385.1 - 0.043 12.6 0.1 0.092 11.5 0.1 1.6 1 0 0 1 1 1 0 Sulfate permease family Sec20 PF03908.13 EFC45385.1 - 0.094 12.6 2.0 1.1 9.2 0.1 3.5 3 1 1 4 4 4 0 Sec20 Y_phosphatase2 PF03162.13 EFC45386.1 - 1.2e-51 174.5 0.0 1.4e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 EFC45386.1 - 3.5e-05 23.9 0.0 4.5e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family FWWh PF14922.6 EFC45387.1 - 1e-12 48.2 2.9 5e-12 46.0 1.4 2.4 2 0 0 2 2 2 1 Protein of unknown function zf-H3C2 PF16721.5 EFC45387.1 - 0.02 15.3 0.1 0.17 12.3 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger like, probable DNA-binding NIF PF03031.18 EFC45388.1 - 1.6e-34 119.0 0.2 2.2e-34 118.5 0.2 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Thioredoxin PF00085.20 EFC45389.1 - 5.5e-60 199.8 0.3 1.3e-31 108.6 0.2 2.9 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_6 PF13848.6 EFC45389.1 - 2.3e-32 112.4 7.7 1.9e-22 80.1 1.2 3.8 2 1 2 4 4 4 3 Thioredoxin-like domain OST3_OST6 PF04756.13 EFC45389.1 - 8.7e-14 51.6 0.3 7.5e-10 38.6 0.3 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 EFC45389.1 - 8.5e-11 42.0 1.1 0.00067 19.9 0.1 4.2 4 0 0 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 EFC45389.1 - 2e-09 37.4 1.8 8.2e-05 22.5 0.2 3.2 2 1 1 3 3 3 2 AhpC/TSA family Thioredoxin_2 PF13098.6 EFC45389.1 - 2.4e-09 37.6 2.4 0.00017 22.0 0.1 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain ERp29_N PF07912.13 EFC45389.1 - 1.6e-08 34.8 1.3 0.016 15.3 0.1 3.7 3 0 0 3 3 3 2 ERp29, N-terminal domain Redoxin PF08534.10 EFC45389.1 - 7e-06 25.8 1.7 0.02 14.6 0.1 3.4 2 1 1 3 3 3 1 Redoxin Thioredoxin_7 PF13899.6 EFC45389.1 - 9.3e-06 25.7 0.1 0.11 12.7 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like Calsequestrin PF01216.17 EFC45389.1 - 1.2e-05 24.6 5.3 2e-05 23.8 5.3 1.4 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_9 PF14595.6 EFC45389.1 - 0.00058 19.6 0.1 0.021 14.6 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin TraF PF13728.6 EFC45389.1 - 0.00072 19.4 0.0 0.058 13.2 0.0 2.4 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 EFC45389.1 - 0.019 15.0 0.1 1.3 9.2 0.0 3.2 2 1 0 3 3 3 0 Thioredoxin domain Thioredoxin_4 PF13462.6 EFC45389.1 - 0.023 14.9 3.4 2.6 8.2 0.1 3.8 3 2 1 4 4 4 0 Thioredoxin DDE_Tnp_1_2 PF13586.6 EFC45389.1 - 0.12 12.8 0.0 9.7 6.6 0.0 2.5 2 0 0 2 2 2 0 Transposase DDE domain Stm1_N PF09598.10 EFC45390.1 - 0.015 16.1 1.8 0.015 16.1 1.8 2.7 3 1 0 3 3 3 0 Stm1 IHABP4_N PF16174.5 EFC45390.1 - 1.5 9.4 23.8 0.87 10.2 21.5 1.6 1 1 1 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal zf-U1 PF06220.12 EFC45391.1 - 9.3e-19 66.9 1.5 1.4e-18 66.3 1.5 1.3 1 0 0 1 1 1 1 U1 zinc finger PGC7_Stella PF15549.6 EFC45391.1 - 1 9.3 5.0 0.31 11.0 2.1 1.6 2 0 0 2 2 2 0 PGC7/Stella/Dppa3 domain Dicty_REP PF05086.12 EFC45391.1 - 1.2 7.1 4.4 1.4 6.8 4.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DnaA_N PF11638.8 EFC45392.1 - 0.062 13.1 0.0 0.087 12.6 0.0 1.3 1 0 0 1 1 1 0 DnaA N-terminal domain SNF2_N PF00176.23 EFC45393.1 - 6.5e-31 107.3 2.9 1.3e-25 89.9 0.2 2.9 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC45393.1 - 0.00053 20.3 0.1 0.0018 18.6 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF498 PF04430.14 EFC45393.1 - 0.049 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) Peptidase_M18 PF02127.15 EFC45394.1 - 3.6e-159 530.2 0.0 4.1e-159 530.0 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 EFC45394.1 - 5.7e-10 38.7 0.3 1e-06 28.0 0.1 2.2 1 1 1 2 2 2 2 M42 glutamyl aminopeptidase Hexapep PF00132.24 EFC45395.1 - 1.6e-10 40.2 12.5 9.1e-06 25.2 3.4 4.6 2 2 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 EFC45395.1 - 6e-08 32.3 10.3 0.00097 18.8 4.0 3.4 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EFC45395.1 - 0.0087 15.0 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 L-fucokinase GlcNAc PF11397.8 EFC45396.1 - 3.6e-60 204.3 0.3 2e-47 162.4 0.1 2.0 1 1 1 2 2 2 2 Glycosyltransferase (GlcNAc) Citrate_synt PF00285.21 EFC45397.1 - 6.9e-104 347.8 0.0 9.8e-104 347.3 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DSPc PF00782.20 EFC45398.1 - 1.5e-06 28.1 0.0 1.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC45398.1 - 3e-05 24.2 0.0 4.2e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFC45398.1 - 4.5e-05 23.5 0.0 5.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC45398.1 - 6.5e-05 22.6 0.0 7e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF2368 PF10166.9 EFC45401.1 - 0.0032 17.1 0.1 0.0064 16.1 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2368) PQQ_2 PF13360.6 EFC45402.1 - 3.6e-07 30.0 0.0 2.8e-05 23.8 0.0 3.0 1 1 1 2 2 2 2 PQQ-like domain PQQ_3 PF13570.6 EFC45402.1 - 0.0031 17.9 0.0 0.15 12.5 0.0 2.7 2 0 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 EFC45402.1 - 0.021 14.8 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat SCAMP PF04144.13 EFC45403.1 - 3.4e-20 73.1 27.2 1.3e-19 71.2 27.2 1.8 1 1 0 1 1 1 1 SCAMP family HHV-5_US34A PF17087.5 EFC45403.1 - 5.1 7.3 6.7 41 4.4 0.0 3.3 3 0 0 3 3 3 0 Herpesvirus US34A protein family p450 PF00067.22 EFC45404.1 - 9.8e-39 133.4 0.0 1.1e-38 133.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Myosin_TH1 PF06017.13 EFC45405.1 - 0.006 16.3 0.2 0.0082 15.8 0.2 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding PH_3 PF14593.6 EFC45405.1 - 0.076 13.1 0.2 0.2 11.8 0.2 1.7 1 0 0 1 1 1 0 PH domain RasGEF PF00617.19 EFC45406.1 - 1.8e-17 64.1 1.7 4.7e-17 62.8 1.7 1.7 1 0 0 1 1 1 1 RasGEF domain F-box-like PF12937.7 EFC45406.1 - 0.25 11.3 4.4 0.068 13.1 0.7 2.0 2 0 0 2 2 2 0 F-box-like NDK PF00334.19 EFC45407.1 - 9.1e-46 155.2 0.0 1e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase OppC_N PF12911.7 EFC45408.1 - 0.18 11.8 2.1 3.5 7.7 0.1 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C CcmD PF04995.14 EFC45408.1 - 0.21 11.7 0.7 0.51 10.5 0.7 1.6 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Pkinase PF00069.25 EFC45409.1 - 3.5e-54 183.9 1.4 5e-54 183.4 1.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45409.1 - 1.9e-33 115.9 0.4 2.8e-33 115.3 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC45409.1 - 5e-25 86.2 7.7 1.7e-06 27.8 0.0 9.3 11 0 0 11 11 11 4 NHL repeat SGL PF08450.12 EFC45409.1 - 1.6e-06 27.9 10.6 2.6 7.5 0.1 8.4 5 2 2 7 7 7 2 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC45409.1 - 2.5e-05 24.4 15.2 3.8 7.8 0.0 7.6 8 1 1 9 9 9 3 Arylesterase TMEM154 PF15102.6 EFC45409.1 - 0.0059 16.5 0.1 0.0059 16.5 0.1 2.0 2 0 0 2 2 1 1 TMEM154 protein family Pkinase_fungal PF17667.1 EFC45409.1 - 0.008 15.0 0.1 0.012 14.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase RCC1 PF00415.18 EFC45409.1 - 0.11 13.1 0.1 0.73 10.5 0.0 2.5 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC45409.1 - 0.12 12.8 11.1 0.31 11.4 11.1 1.7 1 0 0 1 1 1 0 EGF-like domain DUF3827 PF12877.7 EFC45409.1 - 0.2 10.0 0.7 0.28 9.5 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Haspin_kinase PF12330.8 EFC45409.1 - 0.26 10.2 4.4 0.1 11.5 1.1 1.9 2 1 0 2 2 2 0 Haspin like kinase domain Hydrolase_4 PF12146.8 EFC45410.1 - 1.7e-36 125.7 0.5 1.2e-31 109.8 0.0 3.1 3 0 0 3 3 3 3 Serine aminopeptidase, S33 DUF4715 PF15835.5 EFC45410.1 - 0.00018 21.6 0.1 0.00047 20.2 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4715) Abhydrolase_1 PF00561.20 EFC45410.1 - 0.0024 17.5 2.7 1 8.9 0.0 3.6 3 1 0 3 3 3 1 alpha/beta hydrolase fold BAAT_C PF08840.11 EFC45410.1 - 0.013 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ndr PF03096.14 EFC45410.1 - 0.024 13.3 0.0 0.04 12.6 0.0 1.3 1 0 0 1 1 1 0 Ndr family Abhydrolase_2 PF02230.16 EFC45410.1 - 0.035 13.9 0.9 2.3 8.0 0.2 2.8 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase DUF4116 PF13475.6 EFC45411.1 - 1e-128 418.9 23.5 2.8e-16 59.0 0.0 12.0 6 2 7 13 13 13 13 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 EFC45411.1 - 0.00086 19.4 0.2 14 5.7 0.0 5.4 3 3 2 6 6 6 1 Rsbr N terminal DUF4853 PF16145.5 EFC45411.1 - 0.0016 18.5 0.0 7.6 6.7 0.0 3.9 3 1 0 3 3 3 1 Domain of unknown function (DUF4853) DUF1667 PF07892.11 EFC45411.1 - 0.043 13.9 0.0 9.6 6.3 0.0 4.4 5 2 0 5 5 5 0 Protein of unknown function (DUF1667) DUF2703 PF10865.8 EFC45411.1 - 0.08 13.1 0.9 1.3 9.2 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2703) TnsD PF15978.5 EFC45411.1 - 0.11 11.4 8.8 1 8.3 0.2 3.1 3 1 1 4 4 4 0 Tn7-like transposition protein D AAA_18 PF13238.6 EFC45411.1 - 3 8.4 9.3 18 5.9 0.1 3.7 4 0 0 4 4 4 0 AAA domain CbiG_C PF01890.16 EFC45411.1 - 7.3 7.2 5.8 28 5.3 0.1 4.2 3 3 1 4 4 4 0 Cobalamin synthesis G C-terminus DTW PF03942.15 EFC45412.1 - 1.4e-23 83.6 2.4 1.4e-23 83.6 2.4 2.3 1 1 1 2 2 2 2 DTW domain EF-hand_1 PF00036.32 EFC45413.1 - 6.7e-19 66.0 9.1 2.7e-06 26.5 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 EFC45413.1 - 2.6e-16 58.3 7.9 7.4e-06 25.2 0.1 4.3 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC45413.1 - 4e-16 57.5 7.1 3.3e-05 23.5 0.1 4.5 4 1 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EFC45413.1 - 1.5e-15 57.3 5.0 5.5e-08 33.1 0.6 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFC45413.1 - 5e-11 42.3 3.3 1.1e-06 28.3 0.0 3.7 3 1 0 3 3 3 2 EF-hand domain pair Dockerin_1 PF00404.18 EFC45413.1 - 3.8e-05 23.8 0.5 0.65 10.2 0.0 3.4 2 1 1 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 EFC45413.1 - 0.0005 20.0 2.8 2 8.4 0.2 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 EFC45413.1 - 0.0028 17.8 0.0 0.0083 16.3 0.0 1.8 2 1 0 2 2 2 1 p25-alpha EF-hand_9 PF14658.6 EFC45413.1 - 0.0041 17.4 0.4 0.2 12.0 0.0 3.1 4 0 0 4 4 4 1 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC45413.1 - 0.0089 16.3 0.4 1.8 8.9 0.1 3.0 2 2 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region VCBS PF13517.6 EFC45413.1 - 0.33 11.6 2.7 16 6.2 2.7 2.6 1 1 1 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Vps39_2 PF10367.9 EFC45414.1 - 5.4e-34 116.9 2.3 1.5e-33 115.5 2.3 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 EFC45414.1 - 1.5e-25 90.4 0.2 3.5e-25 89.2 0.2 1.6 1 0 0 1 1 1 1 CNH domain Vps39_1 PF10366.9 EFC45414.1 - 1.8e-23 82.9 0.5 1.8e-23 82.9 0.5 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 EFC45414.1 - 1.7e-16 60.3 14.4 1.4e-09 37.9 2.4 3.2 3 0 0 3 3 3 2 Region in Clathrin and VPS WYL_2 PF10902.8 EFC45414.1 - 0.094 13.1 0.4 0.25 11.8 0.4 1.8 1 0 0 1 1 1 0 WYL_2, Sm-like SH3 beta-barrel fold Hira PF07569.11 EFC45414.1 - 0.3 10.8 2.1 0.73 9.5 0.1 2.4 2 0 0 2 2 2 0 TUP1-like enhancer of split zf-HC5HC2H PF13771.6 EFC45414.1 - 1.2 9.4 6.1 0.44 10.8 2.0 2.3 2 0 0 2 2 2 0 PHD-like zinc-binding domain TPR_1 PF00515.28 EFC45414.1 - 1.4 8.9 7.2 2.7 8.0 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat Metallophos PF00149.28 EFC45415.1 - 7.6e-10 39.6 0.0 1.9e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC45415.1 - 0.00018 21.8 2.1 0.00044 20.5 2.1 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DpnD-PcfM PF14207.6 EFC45415.1 - 0.11 12.4 0.5 0.21 11.5 0.5 1.4 1 0 0 1 1 1 0 DpnD/PcfM-like protein cobW PF02492.19 EFC45415.1 - 0.17 11.4 0.2 0.26 10.9 0.2 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PUF PF00806.19 EFC45416.1 - 1.5e-05 24.5 0.9 0.0023 17.5 0.0 4.5 4 0 0 4 4 4 1 Pumilio-family RNA binding repeat DUF2192 PF09958.9 EFC45416.1 - 0.97 8.9 6.4 0.11 12.0 0.5 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2192) DUF2263 PF10021.9 EFC45417.1 - 2.9e-27 95.9 0.0 9.4e-26 90.9 0.0 2.5 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2263) DUF647 PF04884.14 EFC45417.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Vitamin B6 photo-protection and homoeostasis Peptidase_M19 PF01244.21 EFC45418.1 - 9.1e-60 202.5 1.8 1.3e-59 202.0 1.8 1.2 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Amidohydro_2 PF04909.14 EFC45418.1 - 0.00022 21.1 0.0 0.00033 20.5 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Zn_clus PF00172.18 EFC45419.1 - 1.9e-05 24.6 10.5 4.6e-05 23.5 10.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F5_F8_type_C PF00754.25 EFC45420.1 - 4.1e-22 78.6 11.7 1.8e-05 24.8 0.0 7.2 8 0 0 8 8 8 5 F5/8 type C domain DDRGK PF09756.9 EFC45420.1 - 1.1 8.9 6.5 11 5.5 0.0 4.7 6 0 0 6 6 6 0 DDRGK domain Arf PF00025.21 EFC45421.1 - 1.5e-45 154.8 0.0 1.7e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC45421.1 - 4.4e-12 45.8 0.1 7.3e-12 45.1 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC45421.1 - 9.8e-09 35.5 0.0 1.5e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC45421.1 - 1.6e-08 34.3 0.0 1.9e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC45421.1 - 1e-07 31.4 0.8 9.4e-05 21.7 0.0 3.1 2 1 1 3 3 3 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC45421.1 - 4.3e-07 30.0 0.1 6.2e-07 29.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC45421.1 - 6.7e-05 22.4 0.0 9.3e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC45421.1 - 0.00017 21.2 0.7 0.0047 16.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFC45421.1 - 0.0029 17.4 0.2 0.0059 16.4 0.2 1.6 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EFC45421.1 - 0.0092 16.3 0.2 0.64 10.3 0.2 2.2 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EFC45421.1 - 0.01 15.4 0.2 0.046 13.3 0.2 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B PEPCK_ATP PF01293.20 EFC45421.1 - 0.052 12.2 0.1 0.063 11.9 0.1 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA PF00004.29 EFC45421.1 - 0.083 13.3 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFC45421.1 - 0.086 12.7 0.3 6 6.8 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase ACT PF01842.25 EFC45421.1 - 0.13 12.0 0.0 3.6 7.4 0.0 2.6 1 1 0 1 1 1 0 ACT domain Thymidylate_kin PF02223.17 EFC45421.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Thymidylate kinase BTB PF00651.31 EFC45422.1 - 1.3e-15 57.6 1.0 2e-13 50.5 0.4 3.1 2 1 0 2 2 2 2 BTB/POZ domain Ras PF00071.22 EFC45422.1 - 0.00012 21.8 0.1 0.00023 20.8 0.1 1.5 1 0 0 1 1 1 1 Ras family SAP PF02037.27 EFC45423.1 - 9.5e-11 41.2 6.9 2.3e-07 30.4 0.0 4.4 4 0 0 4 4 4 2 SAP domain Sdh5 PF03937.16 EFC45423.1 - 0.066 13.2 0.5 1.2 9.2 0.1 2.7 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase Ish1 PF10281.9 EFC45423.1 - 0.66 10.3 0.0 0.66 10.3 0.0 4.8 6 0 0 6 6 6 0 Putative stress-responsive nuclear envelope protein FGF-BP1 PF06473.12 EFC45423.1 - 1.3 8.8 34.7 0.016 15.0 15.8 2.2 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Med19 PF10278.9 EFC45423.1 - 3.5 7.5 38.5 7.3 6.5 20.7 2.8 2 1 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 EOS1 PF12326.8 EFC45423.1 - 4.9 7.1 8.3 4.3 7.2 0.5 2.2 2 0 0 2 2 2 0 N-glycosylation protein VPS9 PF02204.18 EFC45424.1 - 4.4e-08 33.3 2.5 2.7e-07 30.7 0.4 3.0 3 0 0 3 3 3 1 Vacuolar sorting protein 9 (VPS9) domain MIT PF04212.18 EFC45424.1 - 0.00042 20.3 0.9 0.00098 19.1 0.9 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain HrpF PF06266.12 EFC45424.1 - 0.072 13.4 0.2 12 6.3 0.0 2.7 2 0 0 2 2 2 0 HrpF protein Peptidase_C10 PF01640.17 EFC45424.1 - 0.33 11.2 3.0 5.6 7.2 0.8 2.8 2 1 0 2 2 2 0 Peptidase C10 family RPN6_N PF18055.1 EFC45424.1 - 0.6 10.5 7.9 1.1 9.6 0.2 3.9 4 1 0 4 4 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain LRR_8 PF13855.6 EFC45426.1 - 1.3e-12 47.2 10.6 5.1e-08 32.6 0.8 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EFC45426.1 - 2.7e-08 33.2 11.0 0.083 13.0 0.2 6.4 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 EFC45426.1 - 1.3e-06 28.6 16.9 0.023 15.1 3.1 5.0 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC45426.1 - 0.00012 21.7 0.4 0.05 13.1 0.2 2.1 1 1 1 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EFC45426.1 - 0.01 15.8 1.2 0.034 14.1 0.6 1.5 1 1 1 2 2 2 0 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EFC45426.1 - 0.25 12.0 9.2 2.7 8.9 0.1 5.0 5 2 0 5 5 5 0 Leucine Rich Repeat G-alpha PF00503.20 EFC45427.1 - 7.4e-45 153.6 1.1 7.9e-45 153.5 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC45427.1 - 5.1e-11 42.3 0.1 8.9e-11 41.5 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC45427.1 - 0.027 14.7 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC45427.1 - 0.081 12.5 0.1 0.2 11.3 0.1 1.6 1 1 0 1 1 1 0 Ras family OB_NTP_bind PF07717.16 EFC45428.1 - 8e-21 74.2 0.0 1.8e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFC45428.1 - 4.4e-18 65.6 0.0 1.2e-17 64.1 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 EFC45428.1 - 7.3e-15 55.3 0.8 2e-14 53.9 0.1 2.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain 2OG-FeII_Oxy_2 PF13532.6 EFC45429.1 - 3.4e-19 69.8 0.0 3.8e-18 66.4 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC45429.1 - 0.00043 20.7 0.0 0.00099 19.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily bMG10 PF17973.1 EFC45430.1 - 6.7e-33 113.7 0.0 2.1e-32 112.0 0.0 1.9 2 0 0 2 2 2 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_BRD PF07703.14 EFC45430.1 - 1.2e-16 61.3 2.6 2e-15 57.4 0.3 3.2 2 1 0 2 2 2 1 Alpha-2-macroglobulin bait region domain A2M PF00207.22 EFC45430.1 - 4.2e-14 52.2 0.0 3.7e-13 49.1 0.0 2.5 2 0 0 2 2 2 1 Alpha-2-macroglobulin family MG2 PF01835.19 EFC45430.1 - 1.2e-13 51.3 0.0 5.8e-13 49.1 0.0 2.3 1 0 0 1 1 1 1 MG2 domain Big_5 PF13205.6 EFC45430.1 - 7.4e-07 29.8 6.7 1.8e-05 25.4 0.3 4.7 4 0 0 4 4 4 1 Bacterial Ig-like domain MG4 PF17789.1 EFC45430.1 - 0.00017 21.7 5.7 0.0027 17.8 0.5 4.1 4 0 0 4 4 4 1 Macroglobulin domain MG4 Big_1 PF02369.16 EFC45430.1 - 0.13 12.2 6.7 6.6 6.8 0.0 4.7 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) Guanylate_cyc PF00211.20 EFC45431.1 - 2e-39 135.1 0.0 3.9e-39 134.2 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC45431.1 - 1.5e-17 63.6 0.2 1e-13 51.3 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC45431.1 - 5.7e-09 36.2 0.6 5.4e-06 26.6 0.1 3.0 2 1 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EFC45431.1 - 1.9e-05 24.9 0.0 0.011 16.0 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_11 PF14598.6 EFC45431.1 - 0.00076 19.6 0.0 0.0019 18.3 0.0 1.6 1 0 0 1 1 1 1 PAS domain N_BRCA1_IG PF16158.5 EFC45432.1 - 2e-18 67.0 1.6 2.4e-18 66.7 0.0 2.0 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 EFC45432.1 - 3.6e-08 33.2 0.1 6.7e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TMEM131_like PF12371.8 EFC45432.1 - 0.00056 20.1 0.0 0.0016 18.6 0.0 1.8 1 0 0 1 1 1 1 Transmembrane protein 131-like ASH PF15780.5 EFC45432.1 - 0.021 15.0 0.2 0.087 13.0 0.0 2.1 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF2812 PF11193.8 EFC45432.1 - 0.066 13.4 0.3 17 5.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2812) UN_NPL4 PF11543.8 EFC45432.1 - 0.074 13.5 0.0 0.21 12.1 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Guanylate_cyc PF00211.20 EFC45434.1 - 3.8e-18 65.7 0.3 2.5e-11 43.5 0.0 3.0 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 EFC45434.1 - 5.9e-05 23.5 0.0 0.00014 22.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 EFC45434.1 - 0.00071 19.5 0.0 0.0061 16.5 0.0 2.5 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 EFC45434.1 - 0.011 15.7 0.9 0.011 15.7 0.9 3.0 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea PIF1 PF05970.14 EFC45434.1 - 0.017 14.3 0.0 0.044 13.0 0.0 1.6 1 0 0 1 1 1 0 PIF1-like helicase AAA_22 PF13401.6 EFC45434.1 - 0.028 14.7 0.0 0.14 12.4 0.0 2.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFC45434.1 - 0.03 14.2 0.0 0.09 12.7 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase P16-Arc PF04699.14 EFC45435.1 - 3.6e-34 118.4 0.2 4.2e-34 118.2 0.2 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 EFC45435.1 - 0.00052 20.3 0.0 0.00071 19.9 0.0 1.2 1 0 0 1 1 1 1 Dip2/Utp12 Family REV1_C PF16727.5 EFC45436.1 - 0.046 14.1 0.0 0.13 12.7 0.0 1.7 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain GST_N PF02798.20 EFC45437.1 - 2.1e-07 31.2 0.2 8.7e-05 22.8 0.0 3.1 2 1 1 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC45437.1 - 1e-06 29.0 0.0 1.5e-05 25.3 0.0 2.5 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC45437.1 - 0.0053 16.7 0.0 0.0088 16.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC45437.1 - 0.0065 16.7 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MetRS-N PF09635.10 EFC45437.1 - 0.091 13.3 0.0 0.27 11.8 0.0 1.7 2 0 0 2 2 2 0 MetRS-N binding domain Ras PF00071.22 EFC45438.1 - 2.7e-50 170.1 0.4 3.2e-50 169.9 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45438.1 - 1.1e-19 70.8 0.0 2.2e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45438.1 - 1.4e-10 40.9 0.0 1.8e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC45438.1 - 6e-07 29.2 0.1 1.1e-06 28.3 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EFC45438.1 - 0.00034 20.5 0.2 0.00045 20.1 0.1 1.3 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 EFC45438.1 - 0.0018 18.3 0.1 0.0056 16.7 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC45438.1 - 0.0028 17.2 0.1 0.0058 16.2 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B ISPD_C PF18706.1 EFC45438.1 - 0.03 14.0 0.0 0.054 13.1 0.0 1.4 1 1 0 1 1 1 0 D-ribitol-5-phosphate cytidylyltransferase C-terminal domain RCC1 PF00415.18 EFC45439.1 - 2.6e-22 79.2 0.8 4.8e-05 23.9 0.0 7.1 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45439.1 - 2.9e-15 55.6 0.9 0.00018 21.2 0.1 5.7 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat TGF_beta PF00019.20 EFC45439.1 - 0.13 13.2 0.1 37 5.4 0.0 2.8 2 0 0 2 2 2 0 Transforming growth factor beta like domain Auxin_repressed PF05564.12 EFC45439.1 - 0.14 12.8 2.4 0.27 11.9 2.0 1.6 1 1 0 1 1 1 0 Dormancy/auxin associated protein BUD22 PF09073.10 EFC45439.1 - 0.23 10.7 9.4 0.55 9.5 9.4 1.6 1 1 0 1 1 1 0 BUD22 Mito_carr PF00153.27 EFC45440.1 - 2.1e-65 216.7 2.7 8.9e-23 80.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3764 PF12594.8 EFC45440.1 - 0.015 15.3 0.0 21 5.3 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3764) CH PF00307.31 EFC45441.1 - 2.1e-75 249.9 4.3 1.9e-18 66.6 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFC45441.1 - 3.4e-08 33.2 0.1 0.14 12.0 0.0 4.3 4 0 0 4 4 4 3 CAMSAP CH domain CH_2 PF06294.11 EFC45441.1 - 0.02 15.0 0.0 3.2 8.0 0.0 3.5 4 0 0 4 4 4 0 CH-like domain in sperm protein PARP PF00644.20 EFC45442.1 - 4.1e-10 39.6 0.1 1.1e-09 38.2 0.1 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain LRR_6 PF13516.6 EFC45443.1 - 5.9e-33 110.1 18.6 0.00033 20.5 0.0 9.7 9 0 0 9 9 9 7 Leucine Rich repeat LRR_8 PF13855.6 EFC45443.1 - 1.4e-13 50.4 14.5 1.3e-07 31.3 0.5 5.1 2 2 4 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC45443.1 - 1.6e-13 50.6 18.3 0.0081 16.6 1.2 6.5 4 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45443.1 - 1.2e-10 40.4 10.0 5 8.1 0.0 8.7 9 0 0 9 9 9 3 Leucine Rich Repeat PMT2_N PF17987.1 EFC45443.1 - 1.3 9.2 7.2 5 7.3 0.5 3.0 2 1 1 3 3 3 0 Phosphoethanolamine N-methyltransferase 2 N-terminal Epimerase PF01370.21 EFC45444.1 - 1.1e-18 67.6 0.0 1.4e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC45444.1 - 1.5e-12 47.6 0.4 1.5e-11 44.3 0.4 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFC45444.1 - 1.8e-08 33.9 0.0 2.5e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFC45444.1 - 2.5e-06 26.8 0.2 1.3e-05 24.5 0.2 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFC45444.1 - 0.00032 20.0 0.1 0.001 18.3 0.0 1.9 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 EFC45444.1 - 0.015 14.3 0.0 0.025 13.6 0.0 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Prenyltrans PF00432.21 EFC45445.1 - 0.00048 19.8 0.0 0.0014 18.3 0.0 1.8 1 0 0 1 1 1 1 Prenyltransferase and squalene oxidase repeat Ribosomal_L3 PF00297.22 EFC45446.1 - 1.4e-154 514.6 15.0 1.6e-154 514.4 15.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Remorin_C PF03763.13 EFC45446.1 - 1.6 8.6 9.9 0.25 11.2 2.1 3.0 3 0 0 3 3 3 0 Remorin, C-terminal region RCC1 PF00415.18 EFC45447.1 - 1.6e-37 127.9 3.7 1.1e-10 42.0 0.0 6.8 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45447.1 - 3.9e-26 90.2 16.8 8.9e-09 34.9 0.0 7.0 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC45447.1 - 2.4e-14 53.3 0.0 3.3e-08 33.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Kelch_6 PF13964.6 EFC45447.1 - 0.13 12.6 2.1 10 6.6 0.0 4.1 4 0 0 4 4 4 0 Kelch motif PARG_cat PF05028.14 EFC45448.1 - 7.7e-63 212.8 1.9 1e-62 212.4 1.9 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF1160 PF06648.11 EFC45448.1 - 0.16 11.9 3.3 0.1 12.6 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) EcKinase PF02958.20 EFC45449.1 - 3.6e-21 75.7 3.9 8.7e-21 74.5 3.9 1.6 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 EFC45449.1 - 2e-08 33.6 1.7 2e-08 33.6 1.7 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) APH PF01636.23 EFC45449.1 - 0.0079 16.1 0.1 0.017 15.1 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family RRM_5 PF13893.6 EFC45449.1 - 0.025 14.1 0.1 0.064 12.9 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ADP_ribosyl_GH PF03747.14 EFC45450.1 - 4.1e-56 190.9 0.2 5e-56 190.6 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase DUF616 PF04765.13 EFC45451.1 - 0.0087 15.3 0.3 0.025 13.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF616) F-box-like PF12937.7 EFC45451.1 - 0.092 12.7 0.1 0.29 11.1 0.1 2.0 1 1 0 1 1 1 0 F-box-like F-box PF00646.33 EFC45451.1 - 0.52 10.3 2.4 1.3 9.0 0.2 2.9 3 0 0 3 3 3 0 F-box domain DHHC PF01529.20 EFC45452.1 - 0.12 12.5 2.4 0.16 12.0 1.8 1.5 1 1 0 1 1 1 0 DHHC palmitoyltransferase GTP_EFTU PF00009.27 EFC45453.1 - 1.3e-38 132.5 4.2 1e-36 126.3 4.2 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 EFC45453.1 - 1.7e-20 73.1 6.5 5.7e-19 68.2 6.1 3.0 3 0 0 3 3 2 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 EFC45453.1 - 2e-11 44.0 0.2 9.1e-11 41.8 0.2 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 EFC45453.1 - 3.1e-08 33.3 0.0 8e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 EFC45453.1 - 6.5e-07 29.2 6.4 1.5e-06 28.0 0.3 2.8 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EFC45453.1 - 1.8e-06 27.6 0.4 8.7e-06 25.3 0.4 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.22 EFC45453.1 - 1.8e-06 27.6 0.0 4.4e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45453.1 - 3.7e-05 23.9 0.0 9.5e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC45453.1 - 0.0002 21.3 1.4 0.75 9.7 0.1 2.9 2 1 1 3 3 3 2 RsgA GTPase SRPRB PF09439.10 EFC45453.1 - 0.00051 19.5 0.1 0.0019 17.7 0.1 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit IF2_N PF04760.15 EFC45453.1 - 0.00068 19.4 0.6 0.0024 17.7 0.0 2.2 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region MeaB PF03308.16 EFC45453.1 - 0.0009 18.3 1.3 0.0029 16.6 0.7 2.1 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1_Xtn PF16897.5 EFC45453.1 - 0.0032 17.4 0.3 0.039 14.0 0.0 2.7 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain HTH_11 PF08279.12 EFC45453.1 - 0.19 11.7 0.6 1 9.3 0.0 2.6 3 0 0 3 3 3 0 HTH domain SpoVT_C PF15714.5 EFC45453.1 - 0.3 11.1 8.6 0.054 13.5 4.0 2.0 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor Dynamin_N PF00350.23 EFC45453.1 - 3.9 7.5 8.8 13 5.9 0.0 4.0 4 1 1 5 5 5 0 Dynamin family Beta-lactamase PF00144.24 EFC45455.1 - 2.5e-14 53.2 0.0 4.1e-14 52.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Inhibitor_I69 PF13734.6 EFC45455.1 - 0.0047 17.3 0.2 0.011 16.2 0.0 1.7 2 0 0 2 2 2 1 Spi protease inhibitor DUF2070 PF09843.9 EFC45455.1 - 2.2 6.5 12.5 3.4 5.8 12.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Macoilin PF09726.9 EFC45456.1 - 0.43 9.1 19.4 0.55 8.7 19.4 1.0 1 0 0 1 1 1 0 Macoilin family Borrelia_P83 PF05262.11 EFC45456.1 - 1.5 7.2 19.7 1.7 7.0 19.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FAM60A PF15396.6 EFC45456.1 - 1.9 8.5 8.0 3 7.8 8.0 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Vfa1 PF08432.10 EFC45456.1 - 2.3 8.5 16.6 4.2 7.7 16.6 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 EFC45456.1 - 2.6 7.8 15.7 3.5 7.4 15.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 EFC45456.1 - 4.2 7.6 12.6 5.7 7.1 12.6 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family AAA_13 PF13166.6 EFC45456.1 - 5.9 5.4 18.9 7.8 5.0 18.9 1.1 1 0 0 1 1 1 0 AAA domain Tubulin PF00091.25 EFC45457.1 - 3.4e-66 223.2 0.0 6.1e-66 222.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC45457.1 - 1e-39 135.5 1.4 1.7e-39 134.9 1.4 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC45457.1 - 5.4e-05 23.0 0.0 0.00011 21.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Zn_clus PF00172.18 EFC45458.1 - 1.1e-07 31.9 10.1 2.6e-07 30.6 10.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3465 PF11948.8 EFC45458.1 - 0.069 13.0 0.2 0.17 11.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) DUF913 PF06025.12 EFC45459.1 - 1.2e-21 77.1 0.9 1.2e-21 77.1 0.9 5.1 5 1 0 5 5 5 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 EFC45459.1 - 1.3e-08 34.7 5.0 1.1e-06 28.4 1.5 4.6 4 1 0 5 5 5 2 Domain of Unknown Function (DUF908) UBA PF00627.31 EFC45459.1 - 1.9e-08 34.1 0.7 4.8e-08 32.8 0.7 1.8 1 0 0 1 1 1 1 UBA/TS-N domain CH PF00307.31 EFC45459.1 - 0.00041 20.5 2.3 0.00087 19.5 0.5 2.7 2 0 0 2 2 2 1 Calponin homology (CH) domain Drf_FH3 PF06367.16 EFC45459.1 - 0.0013 18.3 0.0 0.0013 18.3 0.0 4.0 4 1 1 5 5 5 1 Diaphanous FH3 Domain Trimer_CC PF08954.11 EFC45459.1 - 0.017 14.7 2.5 0.061 12.9 2.5 2.1 1 0 0 1 1 1 0 Trimerisation motif RNase_H PF00075.24 EFC45460.1 - 8.2e-15 55.2 2.1 1.4e-14 54.4 0.2 2.4 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 EFC45460.1 - 0.025 14.4 0.2 0.29 11.0 0.0 2.5 2 0 0 2 2 2 0 Reverse transcriptase-like Exonuc_VII_L PF02601.15 EFC45460.1 - 0.033 13.8 0.7 0.076 12.6 0.7 1.6 1 0 0 1 1 1 0 Exonuclease VII, large subunit Metal_resist PF13801.6 EFC45460.1 - 0.039 14.1 0.0 0.078 13.2 0.0 1.4 1 0 0 1 1 1 0 Heavy-metal resistance TBCC_N PF16752.5 EFC45460.1 - 0.3 11.6 9.0 0.05 14.1 0.9 2.9 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Fzo_mitofusin PF04799.13 EFC45460.1 - 0.47 10.0 4.2 0.38 10.3 2.0 2.0 2 0 0 2 2 2 0 fzo-like conserved region MqsA_antitoxin PF15731.5 EFC45460.1 - 1.3 9.2 5.2 0.39 10.8 0.2 2.6 3 0 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA Get5_C PF18514.1 EFC45461.1 - 1.6 8.5 4.6 4.5 7.1 0.1 3.4 3 0 0 3 3 3 0 Get5 C-terminal domain ZapB PF06005.12 EFC45461.1 - 3.6 8.1 8.9 0.23 11.9 3.2 2.0 2 0 0 2 2 2 0 Cell division protein ZapB DUF5492 PF17596.2 EFC45462.1 - 0.11 12.8 2.0 0.36 11.2 1.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5492) DUF1825 PF08855.10 EFC45462.1 - 0.12 12.3 4.5 0.2 11.6 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) EMC3_TMCO1 PF01956.16 EFC45462.1 - 0.26 11.0 4.1 0.57 9.9 4.1 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Ank_5 PF13857.6 EFC45463.1 - 3.4e-05 24.0 0.3 0.003 17.8 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC45463.1 - 0.0027 18.1 0.3 1.6 9.5 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 EFC45463.1 - 0.0031 18.1 3.5 2.5 8.8 0.0 4.6 4 1 2 6 6 6 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC45463.1 - 0.0041 17.7 0.4 0.1 13.2 0.1 3.4 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) LRR_6 PF13516.6 EFC45464.1 - 0.00017 21.4 4.3 0.0022 17.9 0.0 3.4 3 0 0 3 3 3 1 Leucine Rich repeat LRR_4 PF12799.7 EFC45464.1 - 0.062 13.8 5.2 0.2 12.1 3.3 2.7 1 1 0 2 2 2 0 Leucine Rich repeats (2 copies) ASFV_360 PF01671.16 EFC45464.1 - 0.083 12.4 2.4 0.16 11.4 2.4 1.4 1 0 0 1 1 1 0 African swine fever virus multigene family 360 protein BTB_2 PF02214.22 EFC45465.1 - 1.4e-08 35.0 0.3 2e-07 31.2 0.3 2.2 1 1 0 1 1 1 1 BTB/POZ domain HisG_C PF08029.11 EFC45465.1 - 0.067 13.3 0.3 5.6 7.2 0.1 2.4 2 0 0 2 2 2 0 HisG, C-terminal domain MCPVI PF02993.14 EFC45465.1 - 6.9 6.4 7.6 0.68 9.7 1.0 2.2 2 1 0 2 2 2 0 Minor capsid protein VI HAD_2 PF13419.6 EFC45467.1 - 3.8e-21 76.0 0.5 8.4e-21 74.8 0.5 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFC45467.1 - 5.3e-05 23.6 0.0 9.9e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAS-barrel PF09378.10 EFC45467.1 - 0.00014 22.0 1.5 1.1 9.5 0.1 3.3 2 2 1 3 3 3 2 HAS barrel domain DUF3808 PF10300.9 EFC45468.1 - 2e-25 89.5 0.1 2.9e-25 89.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) Acetyltransf_1 PF00583.25 EFC45469.1 - 8.1e-10 39.0 0.1 1.5e-09 38.1 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC45469.1 - 3.7e-07 30.1 0.1 6.5e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC45469.1 - 2.9e-06 27.6 0.1 6.8e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC45469.1 - 4.9e-06 26.6 0.4 4e-05 23.7 0.4 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC45469.1 - 6e-05 22.9 0.0 0.00012 21.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein GNAT_acetyltran PF12746.7 EFC45469.1 - 0.0007 19.2 0.1 0.0011 18.6 0.1 1.5 1 1 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_3 PF13302.7 EFC45469.1 - 0.0022 18.7 0.0 0.0043 17.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC45469.1 - 0.013 15.0 0.8 0.024 14.1 0.8 1.4 1 0 0 1 1 1 0 Putative acetyl-transferase LRR_4 PF12799.7 EFC45471.1 - 0.0072 16.7 8.3 1.6 9.2 0.1 5.6 5 1 2 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC45471.1 - 0.022 14.8 0.0 0.14 12.3 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeat UPF0227 PF05728.12 EFC45473.1 - 5.5e-17 62.3 0.0 7.8e-17 61.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.8 EFC45473.1 - 9.9e-09 34.8 0.0 4.9e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC45473.1 - 6.6e-06 26.0 0.0 0.002 17.8 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC45473.1 - 0.0031 17.0 0.0 0.0036 16.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 EFC45473.1 - 0.069 12.8 0.0 4.5 6.9 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 EFC45473.1 - 0.08 12.7 0.0 0.22 11.3 0.0 1.6 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF4116 PF13475.6 EFC45474.1 - 2.4e-48 161.6 15.2 1.9e-12 46.7 0.0 6.6 3 1 5 8 8 8 7 Domain of unknown function (DUF4116) DUF4249 PF14054.6 EFC45474.1 - 0.06 13.0 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) HTH_Tnp_Tc3_1 PF11427.8 EFC45474.1 - 0.14 12.0 0.1 14 5.6 0.0 2.8 2 1 1 3 3 3 0 Tc3 transposase Cation_ATPase_C PF00689.21 EFC45475.1 - 9.2e-49 165.6 6.2 9.2e-49 165.6 6.2 2.8 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFC45475.1 - 1.3e-37 129.0 1.6 1.3e-37 129.0 1.6 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_N PF00690.26 EFC45475.1 - 2.3e-17 62.4 0.9 6.2e-17 61.0 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFC45475.1 - 9.4e-17 60.9 0.0 1.8e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC45475.1 - 3.7e-08 33.9 0.1 0.00036 20.9 0.0 3.1 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC45475.1 - 0.0044 16.8 0.1 0.009 15.8 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase MCM_N PF14551.6 EFC45475.1 - 0.19 12.3 0.0 0.41 11.3 0.0 1.5 1 0 0 1 1 1 0 MCM N-terminal domain Peptidase_M8 PF01457.16 EFC45476.1 - 7.3e-20 71.1 3.4 2.4e-19 69.5 3.4 1.6 1 1 0 1 1 1 1 Leishmanolysin Peptidase_M8 PF01457.16 EFC45477.1 - 0.00065 18.5 0.1 0.00075 18.3 0.1 1.1 1 0 0 1 1 1 1 Leishmanolysin MoaF_C PF17409.2 EFC45477.1 - 0.088 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 MoaF C-terminal domain Ras PF00071.22 EFC45478.1 - 8.6e-41 139.2 0.2 1.5e-40 138.4 0.2 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC45478.1 - 1.5e-14 54.2 0.1 4.8e-14 52.6 0.1 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GCV_H PF01597.19 EFC45478.1 - 0.029 14.3 0.1 0.042 13.7 0.1 1.2 1 0 0 1 1 1 0 Glycine cleavage H-protein CENP-M PF11111.8 EFC45478.1 - 0.041 13.1 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) DUF4191 PF13829.6 EFC45479.1 - 5.6 6.2 9.3 1.1 8.6 5.0 1.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4191) Ninjurin PF04923.12 EFC45479.1 - 6.4 6.8 10.1 16 5.5 8.0 2.4 1 1 1 2 2 2 0 Ninjurin PRA1 PF03208.19 EFC45479.1 - 10 5.8 22.3 8.3 6.0 0.4 3.0 2 1 1 3 3 3 0 PRA1 family protein Mito_carr PF00153.27 EFC45480.1 - 1.5e-30 104.9 6.0 8.5e-16 57.7 0.1 2.9 2 1 0 2 2 2 2 Mitochondrial carrier protein MOSC_N PF03476.16 EFC45482.1 - 4.5e-28 97.5 0.0 8.8e-28 96.6 0.0 1.5 2 0 0 2 2 2 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 EFC45482.1 - 2.8e-13 50.0 0.0 4.8e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 MOSC domain DUF4523 PF15023.6 EFC45482.1 - 0.07 13.0 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) SPX PF03105.19 EFC45483.1 - 0.075 12.9 12.9 0.089 12.7 12.9 1.3 1 0 0 1 1 1 0 SPX domain Imm5 PF14423.6 EFC45483.1 - 0.84 9.8 6.8 3.9 7.7 0.2 2.3 1 1 1 2 2 2 0 Immunity protein Imm5 UPF0449 PF15136.6 EFC45483.1 - 1.9 9.0 9.4 0.58 10.6 5.3 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Macro PF01661.21 EFC45485.1 - 1e-12 48.2 0.0 2.1e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 Macro domain Abhydrolase_1 PF00561.20 EFC45485.1 - 0.052 13.2 0.2 1.7 8.3 0.2 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold GDC-P PF02347.16 EFC45486.1 - 3.8e-181 602.6 0.4 1.6e-168 561.0 0.1 2.8 3 0 0 3 3 3 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 EFC45486.1 - 1.1e-10 41.1 0.3 1.3e-08 34.3 0.0 2.3 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 EFC45486.1 - 6.7e-05 22.3 0.0 0.00018 20.9 0.0 1.7 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 EFC45486.1 - 0.0035 16.1 0.4 2.1 7.0 0.0 2.9 3 0 0 3 3 3 2 Pyridoxal-dependent decarboxylase conserved domain CorA PF01544.18 EFC45487.1 - 2.9e-11 43.2 7.5 1.2e-10 41.2 7.5 1.8 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein CUE PF02845.16 EFC45487.1 - 0.0039 16.9 0.5 0.11 12.2 0.1 3.1 4 0 0 4 4 4 1 CUE domain DUF5082 PF16888.5 EFC45487.1 - 0.0097 16.2 3.7 0.0097 16.2 3.7 1.5 2 0 0 2 2 1 1 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.12 EFC45487.1 - 0.01 15.9 3.5 0.24 11.4 0.5 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AICARFT_IMPCHas PF01808.18 EFC45487.1 - 0.037 13.5 0.6 0.06 12.8 0.6 1.3 1 0 0 1 1 1 0 AICARFT/IMPCHase bienzyme DUF745 PF05335.13 EFC45487.1 - 0.057 13.1 1.7 0.18 11.5 1.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF745) UCH PF00443.29 EFC45487.1 - 0.059 12.9 0.1 0.18 11.2 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Snapin_Pallidin PF14712.6 EFC45487.1 - 0.075 13.5 5.2 0.73 10.3 0.3 2.6 2 0 0 2 2 2 0 Snapin/Pallidin RPW8 PF05659.11 EFC45487.1 - 0.11 12.1 3.1 2.7 7.7 0.2 2.5 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 EF-G-binding_N PF07299.11 EFC45487.1 - 0.14 12.7 5.7 0.42 11.2 1.1 2.5 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DUF5071 PF16804.5 EFC45487.1 - 0.19 12.0 3.8 1 9.7 1.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5071) DUF1664 PF07889.12 EFC45487.1 - 0.25 11.4 5.9 1.7 8.7 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LXG PF04740.12 EFC45487.1 - 0.3 10.8 9.6 0.81 9.4 2.4 2.3 1 1 1 2 2 2 0 LXG domain of WXG superfamily Spectrin PF00435.21 EFC45487.1 - 0.5 10.9 6.6 5.8 7.5 1.2 2.6 1 1 2 3 3 3 0 Spectrin repeat YojJ PF10372.9 EFC45487.1 - 0.79 9.9 7.1 0.2 11.8 2.0 2.5 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus GAT PF03127.14 EFC45487.1 - 1.1 9.7 6.8 0.99 9.8 0.9 2.7 1 1 2 3 3 3 0 GAT domain HalX PF08663.10 EFC45487.1 - 1.8 8.9 5.0 6.3 7.2 0.6 3.0 3 0 0 3 3 3 0 HalX domain HIP1_clath_bdg PF16515.5 EFC45487.1 - 2.1 9.0 6.1 3.5 8.3 0.9 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Prefoldin_2 PF01920.20 EFC45487.1 - 3.4 7.7 10.1 4.9 7.2 5.5 3.0 2 1 1 3 3 3 0 Prefoldin subunit Med8 PF10232.9 EFC45487.1 - 4.7 6.7 6.6 0.95 9.0 0.2 2.7 3 1 1 4 4 4 0 Mediator of RNA polymerase II transcription complex subunit 8 WD40 PF00400.32 EFC45488.1 - 6.4e-26 90.1 26.4 9.8e-06 26.2 0.6 10.0 9 0 0 9 9 9 6 WD domain, G-beta repeat G-patch_2 PF12656.7 EFC45488.1 - 2.2e-16 59.7 0.2 2.2e-16 59.7 0.2 2.0 2 0 0 2 2 2 1 G-patch domain ANAPC4_WD40 PF12894.7 EFC45488.1 - 3.1e-14 53.0 5.8 0.084 13.2 0.0 8.3 5 1 4 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain G-patch PF01585.23 EFC45488.1 - 8.4e-05 22.4 0.5 0.00051 19.9 0.2 2.2 2 0 0 2 2 2 1 G-patch domain KOW PF00467.29 EFC45488.1 - 0.0053 16.7 0.4 0.021 14.7 0.1 2.1 2 0 0 2 2 2 1 KOW motif Nup160 PF11715.8 EFC45488.1 - 0.02 13.5 9.2 3.7 6.1 0.1 5.3 3 1 2 5 5 5 0 Nucleoporin Nup120/160 SdiA-regulated PF06977.11 EFC45488.1 - 0.039 13.2 0.0 0.2 10.9 0.0 2.1 2 0 0 2 2 2 0 SdiA-regulated TPR_19 PF14559.6 EFC45488.1 - 0.18 12.3 1.7 56 4.3 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Trypsin PF00089.26 EFC45489.1 - 1.3e-36 126.5 0.9 2.8e-36 125.4 0.9 1.6 1 1 0 1 1 1 1 Trypsin Peptidase_M76 PF09768.9 EFC45489.1 - 3e-29 102.0 5.2 3e-29 102.0 5.2 1.8 2 0 0 2 2 2 1 Peptidase M76 family Phytoreo_P8 PF07124.11 EFC45489.1 - 0.0024 16.9 0.1 0.0052 15.8 0.0 1.5 2 0 0 2 2 2 1 Phytoreovirus outer capsid protein P8 SprT-like PF10263.9 EFC45489.1 - 0.0033 17.3 0.0 0.027 14.3 0.0 2.1 2 0 0 2 2 2 1 SprT-like family RAP80_UIM PF18282.1 EFC45489.1 - 0.066 13.0 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif DUF1986 PF09342.11 EFC45489.1 - 0.1 13.0 0.7 0.86 10.0 0.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1986) DUF2268 PF10026.9 EFC45489.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) PPR_2 PF13041.6 EFC45490.1 - 4.8e-07 29.9 0.6 0.061 13.5 0.0 3.0 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 EFC45490.1 - 0.00057 19.9 13.1 0.0025 17.9 0.4 4.2 5 0 0 5 5 5 2 Pentatricopeptide repeat domain FlgN PF05130.12 EFC45490.1 - 0.0098 16.4 0.5 0.0098 16.4 0.5 2.6 2 0 0 2 2 2 1 FlgN protein Peroxin-22 PF12827.7 EFC45490.1 - 0.39 10.6 5.4 0.14 12.1 0.3 2.5 2 0 0 2 2 2 0 Peroxisomal biogenesis protein family CENP-H PF05837.12 EFC45490.1 - 4 7.9 10.9 3.2 8.2 7.0 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) CHD5 PF04420.14 EFC45490.1 - 4.9 7.0 10.4 1.6 8.5 7.0 2.1 2 0 0 2 2 2 0 CHD5-like protein Methyltrans_RNA PF04452.14 EFC45491.1 - 1e-25 90.4 0.5 1.2e-25 90.1 0.5 1.0 1 0 0 1 1 1 1 RNA methyltransferase HMA PF00403.26 EFC45492.1 - 0.0073 16.7 0.0 0.019 15.4 0.0 1.8 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF3987 PF13148.6 EFC45492.1 - 0.062 12.3 0.4 0.12 11.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) ParB PF08775.10 EFC45492.1 - 0.12 12.8 5.5 2.8 8.4 0.8 2.7 2 0 0 2 2 2 0 ParB family PIN_6 PF17146.4 EFC45492.1 - 0.58 10.7 3.1 3 8.4 0.0 3.2 1 1 3 4 4 4 0 PIN domain of ribonuclease Cofilin_ADF PF00241.20 EFC45493.1 - 1.1e-20 73.7 0.3 1.2e-20 73.5 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein PAP_assoc PF03828.19 EFC45494.1 - 7.8e-18 64.4 0.3 6.2e-17 61.6 0.6 2.4 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 EFC45494.1 - 0.011 16.1 4.3 0.074 13.4 4.2 2.6 1 1 0 1 1 1 0 Nucleotidyltransferase domain DUF2052 PF09747.9 EFC45494.1 - 2 8.5 14.8 9.1 6.4 0.9 2.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) BLOC1_2 PF10046.9 EFC45495.1 - 0.0015 18.8 7.4 0.0015 18.8 7.4 6.3 2 2 3 6 6 6 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 EFC45495.1 - 1.7 8.7 70.1 0.063 13.3 19.0 5.8 2 1 2 6 6 6 0 TPR/MLP1/MLP2-like protein Glu-tRNAGln PF02686.15 EFC45495.1 - 2.7 8.3 5.2 23 5.4 0.1 3.6 3 0 0 3 3 3 0 Glu-tRNAGln amidotransferase C subunit Synapsin_C PF02750.14 EFC45496.1 - 2.8e-50 170.7 0.1 3.9e-50 170.2 0.1 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 EFC45496.1 - 3.1e-21 75.6 0.0 5.2e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Synapsin, N-terminal domain R2K_3 PF14243.6 EFC45496.1 - 0.0033 17.5 0.0 0.0083 16.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 Myb_DNA-binding PF00249.31 EFC45497.1 - 3.7e-09 36.6 0.3 7.2e-09 35.7 0.3 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Vps5 PF09325.10 EFC45498.1 - 2.9e-26 92.5 17.2 4.3e-26 91.9 16.7 1.6 1 1 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 EFC45498.1 - 3.5e-20 72.1 0.2 1.3e-19 70.2 0.2 2.1 1 0 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.9 EFC45498.1 - 4.7e-06 26.3 10.4 4.7e-06 26.3 10.4 2.6 2 1 0 2 2 2 1 WASP-binding domain of Sorting nexin protein tRNA_anti-codon PF01336.25 EFC45498.1 - 0.12 12.4 0.3 0.54 10.3 0.1 2.2 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain STE PF02200.16 EFC45498.1 - 0.22 12.0 3.1 5 7.6 0.1 3.7 4 0 0 4 4 4 0 STE like transcription factor Ribosomal_L29e PF01779.17 EFC45499.1 - 2.9e-08 33.9 15.0 4.5e-08 33.3 15.0 1.5 1 1 0 1 1 1 1 Ribosomal L29e protein family PIG-L PF02585.17 EFC45500.1 - 3.1e-21 76.4 0.0 4.6e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase CtnDOT_TraJ PF07863.11 EFC45501.1 - 5 7.8 6.0 15 6.3 0.2 2.8 3 0 0 3 3 3 0 Homologues of TraJ from Bacteroides conjugative transposon NHL PF01436.21 EFC45502.1 - 4.4e-22 76.9 2.0 2.7e-08 33.4 0.0 5.7 5 1 0 5 5 5 4 NHL repeat Arylesterase PF01731.20 EFC45502.1 - 7.8e-11 42.0 2.4 0.028 14.6 0.2 4.7 3 2 2 5 5 5 3 Arylesterase SGL PF08450.12 EFC45502.1 - 6.7e-09 35.7 0.0 0.16 11.5 0.0 3.8 2 1 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region DUF5128 PF17170.4 EFC45502.1 - 4.3e-07 29.4 5.7 0.00038 19.7 0.2 3.0 2 1 0 3 3 3 2 6-bladed beta-propeller PQQ_2 PF13360.6 EFC45502.1 - 0.0013 18.4 0.0 0.014 15.0 0.0 2.0 1 1 1 2 2 2 1 PQQ-like domain DUF677 PF05055.12 EFC45502.1 - 0.0046 15.9 0.1 0.0069 15.3 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF677) DUF4221 PF13970.6 EFC45502.1 - 0.0049 16.5 4.7 0.016 14.8 1.7 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF4221) ANAPC4_WD40 PF12894.7 EFC45502.1 - 0.016 15.5 0.0 2.1 8.7 0.0 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFC45502.1 - 0.026 13.0 0.0 0.041 12.4 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain MRJP PF03022.16 EFC45502.1 - 0.029 13.7 0.3 11 5.2 0.1 3.3 2 1 1 3 3 3 0 Major royal jelly protein Lactonase PF10282.9 EFC45502.1 - 0.057 12.7 0.1 8 5.6 0.1 3.3 2 2 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Kelch_6 PF13964.6 EFC45502.1 - 0.069 13.5 1.4 12 6.3 0.0 3.9 3 1 2 5 5 5 0 Kelch motif Indigoidine_A PF04227.12 EFC45503.1 - 2.5e-130 434.1 0.5 2.8e-130 433.9 0.5 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein Ank_5 PF13857.6 EFC45504.1 - 3.2e-05 24.1 0.1 0.001 19.3 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC45504.1 - 0.0003 21.3 0.4 0.0014 19.2 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC45504.1 - 0.0022 18.6 0.6 0.0059 17.2 0.6 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC45504.1 - 0.013 16.0 1.9 0.037 14.6 0.2 2.7 3 0 0 3 3 3 0 Ankyrin repeat EST1 PF10374.9 EFC45504.1 - 0.12 13.0 4.8 0.94 10.1 0.3 2.8 2 0 0 2 2 2 0 Telomerase activating protein Est1 Carb_kinase PF01256.17 EFC45505.1 - 1.6e-48 165.3 0.0 2.8e-48 164.5 0.0 1.3 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 EFC45505.1 - 0.017 14.5 0.0 0.082 12.3 0.0 1.9 2 0 0 2 2 2 0 Phosphomethylpyrimidine kinase HK PF02110.15 EFC45505.1 - 0.11 11.8 0.0 0.3 10.4 0.0 1.7 1 1 0 1 1 1 0 Hydroxyethylthiazole kinase family DUF4238 PF14022.6 EFC45505.1 - 0.16 11.5 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) RNA_ligase PF09414.10 EFC45507.1 - 1.4e-26 93.8 0.1 1.7e-26 93.5 0.1 1.1 1 0 0 1 1 1 1 RNA ligase Vps26 PF03643.15 EFC45508.1 - 0.0064 15.5 0.1 0.011 14.8 0.1 1.3 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Phospholip_B PF04916.13 EFC45509.1 - 5.9e-163 543.2 8.1 7.2e-163 543.0 8.1 1.0 1 0 0 1 1 1 1 Phospholipase B CG-1 PF03859.16 EFC45510.1 - 0.15 11.9 0.8 0.33 10.8 0.2 1.9 2 0 0 2 2 2 0 CG-1 domain preATP-grasp_3 PF18301.1 EFC45511.1 - 0.055 13.7 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 pre ATP-grasp 3 domain TIP41 PF04176.13 EFC45512.1 - 3.3e-48 163.4 1.1 3.7e-48 163.2 1.1 1.0 1 0 0 1 1 1 1 TIP41-like family ANAPC10 PF03256.16 EFC45514.1 - 3.4e-63 212.6 2.4 3.4e-63 212.6 2.4 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex, subunit 10 (APC10) PITH PF06201.13 EFC45514.1 - 0.0013 19.0 1.7 0.0024 18.1 1.6 1.8 1 1 0 1 1 1 1 PITH domain LRR_6 PF13516.6 EFC45515.1 - 7.8e-40 131.6 57.3 0.00017 21.4 0.1 17.2 17 0 0 17 17 17 14 Leucine Rich repeat LRR_8 PF13855.6 EFC45515.1 - 4.8e-24 83.9 45.9 1.1e-05 25.1 5.6 8.2 1 1 10 12 12 12 11 Leucine rich repeat LRR_4 PF12799.7 EFC45515.1 - 3e-22 78.3 53.9 0.00013 22.3 2.2 10.3 5 2 6 11 11 11 10 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC45515.1 - 3.1e-08 33.3 17.4 0.0077 15.8 3.5 4.5 1 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EFC45515.1 - 7.5e-07 28.8 32.5 7.8 7.5 0.1 12.9 13 2 1 14 14 14 3 Leucine Rich Repeat Ribosomal_L12_N PF16320.5 EFC45515.1 - 1.4 8.7 7.2 17 5.3 0.1 4.5 4 0 0 4 4 4 0 Ribosomal protein L7/L12 dimerisation domain RNase_H PF00075.24 EFC45516.1 - 8.9e-07 29.2 0.5 3.3e-05 24.1 0.1 3.0 1 1 1 2 2 2 1 RNase H HTH_40 PF14493.6 EFC45516.1 - 0.19 12.2 6.0 0.49 10.9 0.1 3.8 3 0 0 3 3 3 0 Helix-turn-helix domain Rootletin PF15035.6 EFC45516.1 - 0.34 10.9 9.1 0.12 12.4 5.5 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion zf-A20 PF01754.16 EFC45517.1 - 1.2e-09 38.0 9.1 2e-09 37.2 9.1 1.4 1 0 0 1 1 1 1 A20-like zinc finger Dus PF01207.17 EFC45518.1 - 3.5e-66 223.4 0.0 4.3e-66 223.1 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) IMPDH PF00478.25 EFC45518.1 - 0.0062 15.6 0.0 0.0078 15.3 0.0 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 EFC45518.1 - 0.0066 15.5 0.0 0.22 10.5 0.0 2.0 1 1 1 2 2 2 1 FMN-dependent dehydrogenase ER PF01133.17 EFC45518.1 - 0.021 14.8 0.0 3.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Enhancer of rudimentary Peptidase_U32 PF01136.19 EFC45518.1 - 0.055 12.6 0.3 13 4.8 0.0 2.9 2 1 1 3 3 3 0 Peptidase family U32 G3P_antiterm PF04309.12 EFC45518.1 - 0.074 12.5 0.0 0.22 10.9 0.0 1.8 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Ubie_methyltran PF01209.18 EFC45518.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SBP_bac_3 PF00497.20 EFC45519.1 - 3.2e-14 52.9 0.0 4.8e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 FMO-like PF00743.19 EFC45520.1 - 3.4e-69 233.7 2.9 2e-68 231.2 2.9 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 EFC45520.1 - 2.5e-10 40.0 0.0 6.6e-08 32.1 0.0 3.0 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFC45520.1 - 1.4e-06 27.8 0.1 0.38 10.0 0.0 3.6 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC45520.1 - 0.00023 21.2 0.0 0.0015 18.6 0.0 2.4 3 1 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 EFC45520.1 - 0.00035 19.9 0.0 0.012 14.8 0.0 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFC45520.1 - 0.00066 19.0 0.1 0.058 12.6 0.0 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_8 PF13450.6 EFC45520.1 - 0.0014 18.8 0.3 0.015 15.5 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Eno-Rase_NADH_b PF12242.8 EFC45520.1 - 0.019 14.7 0.0 0.45 10.3 0.0 2.5 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF498 PF04430.14 EFC45520.1 - 0.021 14.9 0.0 0.72 9.9 0.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF498/DUF598) ThiF PF00899.21 EFC45520.1 - 0.077 12.3 0.2 9.8 5.4 0.2 2.6 3 0 0 3 3 3 0 ThiF family PGAP1 PF07819.13 EFC45520.1 - 0.11 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein DUF4116 PF13475.6 EFC45521.1 - 1.5e-40 136.7 4.1 1.3e-10 40.8 0.0 5.2 2 2 3 5 5 5 5 Domain of unknown function (DUF4116) SCF PF02404.15 EFC45521.1 - 0.033 13.5 0.1 0.16 11.3 0.0 1.9 1 1 1 2 2 2 0 Stem cell factor ubiquitin PF00240.23 EFC45521.1 - 0.11 12.3 0.0 5.7 6.8 0.0 2.5 1 1 1 2 2 2 0 Ubiquitin family RNase_HII PF01351.18 EFC45522.1 - 7.8e-50 169.5 1.1 9e-50 169.3 1.1 1.0 1 0 0 1 1 1 1 Ribonuclease HII Cyclin_C_2 PF16899.5 EFC45522.1 - 0.061 13.7 0.4 0.3 11.5 0.1 2.1 2 0 0 2 2 2 0 Cyclin C-terminal domain Myb_DNA-bind_6 PF13921.6 EFC45524.1 - 5.2e-17 61.8 6.7 9.7e-15 54.6 1.5 2.8 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFC45524.1 - 2.5e-15 56.4 0.9 6.7e-07 29.4 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFC45524.1 - 0.014 15.6 3.6 0.031 14.4 2.5 2.2 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 ARID PF01388.21 EFC45524.1 - 0.08 13.6 0.3 3.1 8.5 0.0 2.8 2 1 0 2 2 2 0 ARID/BRIGHT DNA binding domain DUF4193 PF13834.6 EFC45524.1 - 3.5 8.2 8.7 3.3 8.3 5.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4193) EF-hand_7 PF13499.6 EFC45525.1 - 6.2e-25 87.4 8.0 9.3e-17 61.3 1.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC45525.1 - 1.3e-24 83.9 14.6 2.5e-09 36.0 0.6 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 EFC45525.1 - 3.6e-23 79.5 10.9 3.8e-09 35.7 0.5 4.2 3 1 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EFC45525.1 - 1.7e-21 75.8 11.2 1.1e-13 50.8 0.7 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFC45525.1 - 1.9e-12 46.0 14.3 9.3e-06 24.9 0.6 3.6 3 1 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 EFC45525.1 - 2.9e-11 43.5 0.4 3.8e-07 30.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFC45525.1 - 2.5e-08 33.8 5.3 2.1e-05 24.4 0.3 2.5 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand DUF3008 PF11450.8 EFC45525.1 - 0.001 19.2 0.2 0.0027 17.8 0.2 1.7 1 0 0 1 1 1 1 Protein of unknwon function (DUF3008) Caleosin PF05042.13 EFC45525.1 - 0.0031 17.4 0.2 0.49 10.3 0.0 2.9 2 1 1 3 3 3 1 Caleosin related protein EF-hand_14 PF17959.1 EFC45525.1 - 0.0037 17.6 1.9 1.7 9.1 0.3 2.3 2 0 0 2 2 2 2 EF-hand domain Staphylokinase PF02821.16 EFC45525.1 - 0.0042 17.5 0.7 0.078 13.4 0.6 2.5 1 1 1 2 2 2 1 Staphylokinase/Streptokinase family SPARC_Ca_bdg PF10591.9 EFC45525.1 - 0.0073 16.6 2.7 1 9.7 0.2 2.3 1 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF3164 PF11363.8 EFC45525.1 - 0.014 15.1 0.6 0.42 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3164) PhetRS_B1 PF18262.1 EFC45525.1 - 0.027 14.7 0.5 0.027 14.7 0.5 2.1 3 0 0 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain Peptidase_M24 PF00557.24 EFC45525.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.5 2 0 0 2 2 2 0 Metallopeptidase family M24 DUF1296 PF06972.11 EFC45525.1 - 0.092 12.9 4.4 2.7 8.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1296) HTH_40 PF14493.6 EFC45525.1 - 0.11 12.9 1.9 1.9 9.0 0.1 2.4 2 1 0 2 2 2 0 Helix-turn-helix domain TerB PF05099.13 EFC45525.1 - 0.12 12.3 2.1 3.8 7.5 0.1 2.5 1 1 2 3 3 3 0 Tellurite resistance protein TerB Cofilin_ADF PF00241.20 EFC45527.1 - 2.8e-76 253.1 9.3 1.4e-14 53.9 0.0 8.5 8 0 0 8 8 8 8 Cofilin/tropomyosin-type actin-binding protein Carot_N PF09150.10 EFC45527.1 - 0.083 12.8 0.0 0.25 11.2 0.0 1.8 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal FAM199X PF15814.5 EFC45527.1 - 0.16 11.0 12.5 0.39 9.7 12.5 1.6 1 0 0 1 1 1 0 Protein family FAM199X Macoilin PF09726.9 EFC45527.1 - 7.6 5.0 16.7 0.3 9.6 9.4 2.1 2 0 0 2 2 2 0 Macoilin family ABC_membrane PF00664.23 EFC45530.1 - 1.5e-50 172.4 28.8 3.1e-31 109.1 19.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 EFC45530.1 - 7.6e-49 165.7 0.0 3.6e-27 95.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter RsgA_GTPase PF03193.16 EFC45530.1 - 7.9e-08 32.4 0.1 0.00016 21.6 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 EFC45530.1 - 4.9e-07 29.4 1.2 0.013 15.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain DUF87 PF01935.17 EFC45530.1 - 5.5e-06 26.6 2.5 0.042 13.9 0.2 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain SMC_N PF02463.19 EFC45530.1 - 1.3e-05 24.7 15.2 0.011 15.2 0.2 4.5 3 2 0 4 4 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFC45530.1 - 1.5e-05 25.1 3.1 0.12 12.4 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase T2SSE PF00437.20 EFC45530.1 - 0.00014 21.0 0.1 0.11 11.5 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_16 PF13191.6 EFC45530.1 - 0.00022 21.7 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_24 PF13479.6 EFC45530.1 - 0.00027 20.7 0.3 0.091 12.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFC45530.1 - 0.00041 20.6 2.4 0.97 9.7 0.3 3.2 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EFC45530.1 - 0.00051 19.3 0.0 0.74 8.9 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain AAA_7 PF12775.7 EFC45530.1 - 0.00097 18.7 0.2 1.4 8.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region ATP_bind_1 PF03029.17 EFC45530.1 - 0.0015 18.4 0.1 2.6 7.8 0.0 2.7 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EFC45530.1 - 0.0019 18.3 8.1 0.044 13.8 0.0 4.2 5 0 0 5 5 4 1 Dynamin family AAA_25 PF13481.6 EFC45530.1 - 0.0029 17.2 0.0 1.7 8.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 EFC45530.1 - 0.0029 17.6 0.2 8.5 6.4 0.0 3.8 2 1 1 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 EFC45530.1 - 0.0067 15.8 0.2 0.89 8.8 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family NACHT PF05729.12 EFC45530.1 - 0.0082 16.1 0.8 3.8 7.4 0.1 2.6 2 0 0 2 2 2 1 NACHT domain AAA_21 PF13304.6 EFC45530.1 - 0.0085 15.9 5.1 2 8.2 1.0 3.5 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 EFC45530.1 - 0.011 14.8 0.1 2.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Septin PF00735.18 EFC45530.1 - 0.012 15.0 1.1 3.1 7.0 0.0 2.9 3 0 0 3 3 3 0 Septin ResIII PF04851.15 EFC45530.1 - 0.015 15.3 0.5 26 4.8 0.0 3.4 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 EFC45530.1 - 0.018 14.3 1.0 2 7.6 0.0 2.8 3 0 0 3 3 2 0 Zeta toxin Viral_helicase1 PF01443.18 EFC45530.1 - 0.022 14.5 0.1 4.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Roc PF08477.13 EFC45530.1 - 0.023 14.9 1.4 12 6.2 0.1 3.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 EFC45530.1 - 0.032 14.6 0.5 5.1 7.5 0.0 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 EFC45530.1 - 0.034 13.9 0.3 7.4 6.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_15 PF13175.6 EFC45530.1 - 0.037 13.8 7.7 1.9 8.1 0.3 3.0 2 1 0 2 2 2 0 AAA ATPase domain cobW PF02492.19 EFC45530.1 - 0.061 12.9 1.2 8.4 5.9 0.2 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 EFC45530.1 - 0.18 11.7 1.1 3.3 7.6 0.1 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Ploopntkinase3 PF18751.1 EFC45530.1 - 0.21 11.5 0.1 21 5.0 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_33 PF13671.6 EFC45530.1 - 0.31 11.2 2.0 21 5.3 0.1 2.7 2 1 0 2 2 2 0 AAA domain AIG1 PF04548.16 EFC45530.1 - 0.34 10.2 2.6 2.8 7.2 0.2 2.6 2 0 0 2 2 2 0 AIG1 family AAA_23 PF13476.6 EFC45530.1 - 0.8 10.2 16.1 7.1 7.1 0.1 3.3 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 EFC45530.1 - 0.97 9.3 3.7 23 4.9 0.0 3.0 3 0 0 3 3 3 0 NTPase Beta_elim_lyase PF01212.21 EFC45531.1 - 3.5e-89 299.0 0.0 4.1e-89 298.7 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 EFC45531.1 - 0.012 14.3 0.0 0.03 13.0 0.0 1.5 2 0 0 2 2 2 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DegT_DnrJ_EryC1 PF01041.17 EFC45531.1 - 0.033 13.5 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family LRR_6 PF13516.6 EFC45532.1 - 1.6e-67 217.9 27.6 4.4e-06 26.3 0.0 14.4 15 0 0 15 15 15 10 Leucine Rich repeat LRR_8 PF13855.6 EFC45532.1 - 6.4e-41 137.9 19.2 3.9e-09 36.2 0.1 7.8 6 3 2 9 9 9 6 Leucine rich repeat LRR_4 PF12799.7 EFC45532.1 - 1.4e-37 127.0 25.9 9.4e-05 22.7 0.1 9.8 1 1 12 14 14 14 14 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45532.1 - 6e-25 83.9 5.8 3.8 8.4 0.0 14.0 15 0 0 15 15 15 6 Leucine Rich Repeat LRR_9 PF14580.6 EFC45532.1 - 6.1e-11 42.1 6.0 0.0069 15.9 1.3 4.2 1 1 4 5 5 5 5 Leucine-rich repeat Beta_helix PF13229.6 EFC45532.1 - 0.00049 20.0 18.0 0.033 14.0 1.5 3.8 1 1 2 3 3 3 2 Right handed beta helix region RHH_3 PF12651.7 EFC45532.1 - 0.078 13.0 0.0 43 4.2 0.0 3.4 3 0 0 3 3 3 0 Ribbon-helix-helix domain Ribosomal_L12_N PF16320.5 EFC45532.1 - 0.13 12.0 7.3 91 2.9 0.1 5.2 4 0 0 4 4 4 0 Ribosomal protein L7/L12 dimerisation domain F-box PF00646.33 EFC45533.1 - 0.0049 16.7 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EFC45534.1 - 1.1e-27 93.7 23.1 0.00032 20.5 0.1 9.4 11 0 0 11 11 11 7 Leucine Rich repeat LRR_8 PF13855.6 EFC45534.1 - 1.2e-15 57.0 20.1 0.00021 21.0 1.6 5.6 3 2 3 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC45534.1 - 4.9e-13 49.0 19.7 0.012 16.0 0.1 6.2 4 2 1 6 6 6 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC45534.1 - 0.001 18.9 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 F-box-like LRR_9 PF14580.6 EFC45534.1 - 0.0011 18.5 7.9 0.77 9.2 0.1 3.2 1 1 2 3 3 3 2 Leucine-rich repeat Mannitol_dh PF01232.23 EFC45534.1 - 0.033 14.4 1.4 0.3 11.2 0.1 2.6 2 1 1 3 3 3 0 Mannitol dehydrogenase Rossmann domain VirE_N PF08800.10 EFC45534.1 - 0.037 14.1 0.1 2.9 8.0 0.0 2.7 2 1 0 2 2 2 0 VirE N-terminal domain LRR_1 PF00560.33 EFC45534.1 - 0.092 13.3 13.1 73 4.5 0.6 7.1 8 1 0 8 8 8 0 Leucine Rich Repeat Exo_endo_phos_2 PF14529.6 EFC45535.1 - 0.032 14.1 7.4 0.25 11.2 2.3 3.1 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase SR-25 PF10500.9 EFC45535.1 - 4.6 6.8 10.7 7.9 6.0 10.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1314 PF07013.11 EFC45536.1 - 0.41 10.5 5.4 0.86 9.5 5.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) Mucin PF01456.17 EFC45536.1 - 2.8 7.9 23.5 0.54 10.2 19.8 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein SSP160 PF06933.11 EFC45536.1 - 5 5.2 16.6 7.6 4.6 16.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Collagen PF01391.18 EFC45537.1 - 1.5 8.7 5.3 8.8 6.2 0.2 2.4 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Sporozoite_P67 PF05642.11 EFC45538.1 - 1.7 6.7 6.4 3.4 5.6 6.4 1.5 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 EFC45538.1 - 2.5 6.3 13.8 0.025 12.9 5.0 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF910 PF06014.11 EFC45539.1 - 0.054 13.5 1.0 0.1 12.6 0.1 1.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF910) Phospholip_B PF04916.13 EFC45540.1 - 9.3e-159 529.4 11.6 1.2e-158 529.1 11.6 1.0 1 0 0 1 1 1 1 Phospholipase B Pkinase PF00069.25 EFC45541.1 - 6.1e-37 127.4 0.4 1.4e-35 122.9 0.4 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45541.1 - 1.3e-35 123.0 0.1 2.2e-28 99.3 0.0 3.0 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFC45541.1 - 0.0015 18.5 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC45541.1 - 0.0019 17.2 0.0 0.0036 16.3 0.0 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC45541.1 - 0.0044 15.9 0.0 0.0063 15.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC45541.1 - 0.0069 15.8 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC45541.1 - 0.011 15.1 0.1 0.019 14.3 0.0 1.5 2 0 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 EFC45541.1 - 0.012 14.6 0.1 0.02 13.9 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 EFC45541.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Snapin_Pallidin PF14712.6 EFC45543.1 - 0.0015 18.9 2.5 0.037 14.4 0.2 2.3 2 0 0 2 2 2 1 Snapin/Pallidin DUF2054 PF10218.9 EFC45543.1 - 0.016 15.3 2.9 0.016 15.3 2.9 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2054) DUF4337 PF14235.6 EFC45543.1 - 0.042 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) IFT57 PF10498.9 EFC45543.1 - 0.054 12.4 2.0 0.062 12.3 0.5 1.7 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 EFC45543.1 - 0.058 13.4 1.0 1.8 8.6 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2207 PF09972.9 EFC45543.1 - 0.071 11.9 0.1 0.082 11.7 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMPIT PF07851.13 EFC45543.1 - 0.091 12.0 1.5 0.28 10.4 0.1 2.0 2 0 0 2 2 2 0 TMPIT-like protein DUF4225 PF13988.6 EFC45543.1 - 0.14 11.7 1.7 0.27 10.8 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4225) HBM PF16591.5 EFC45543.1 - 0.21 11.0 1.2 0.25 10.7 0.1 1.6 2 0 0 2 2 2 0 Helical bimodular sensor domain APG6_N PF17675.1 EFC45543.1 - 0.22 12.1 6.1 0.53 10.8 1.0 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region KxDL PF10241.9 EFC45543.1 - 0.48 10.7 3.2 0.83 10.0 0.5 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein Occludin_ELL PF07303.13 EFC45543.1 - 6.8 7.5 8.0 12 6.7 2.2 2.9 2 1 1 3 3 3 0 Occludin homology domain Ras PF00071.22 EFC45544.1 - 8.3e-44 149.0 0.2 1e-43 148.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45544.1 - 6.3e-19 68.4 0.0 9.4e-19 67.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45544.1 - 1.4e-08 34.4 0.0 1.7e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC45544.1 - 0.0018 18.2 0.1 0.95 9.3 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC45544.1 - 0.0019 17.8 0.8 0.0078 15.8 0.5 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC45544.1 - 0.0019 18.2 0.0 0.0037 17.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC45544.1 - 0.02 15.2 0.0 0.052 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF4055 PF13264.6 EFC45544.1 - 0.058 13.5 0.0 0.087 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) AAA_24 PF13479.6 EFC45544.1 - 0.063 13.0 0.1 0.48 10.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC45544.1 - 0.18 12.2 0.0 0.32 11.4 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain BUD22 PF09073.10 EFC45545.1 - 5.7 6.2 65.7 1.9 7.7 27.5 2.3 2 0 0 2 2 2 0 BUD22 Creatinase_N_2 PF16189.5 EFC45546.1 - 5.6e-51 172.8 0.5 5.6e-51 172.8 0.5 2.5 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EFC45546.1 - 5e-40 137.4 0.0 7e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 EFC45546.1 - 7.2e-20 72.0 0.1 3.9e-13 50.2 0.0 2.7 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 EFC45546.1 - 8.7e-20 70.6 0.1 2.3e-19 69.2 0.1 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Sel1 PF08238.12 EFC45547.1 - 1.4e-22 79.6 4.1 9.6e-09 35.6 0.2 4.9 5 0 0 5 5 5 4 Sel1 repeat DUF3089 PF11288.8 EFC45547.1 - 0.014 15.0 0.0 0.44 10.1 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3089) TPR_8 PF13181.6 EFC45547.1 - 9.3 6.8 9.1 14 6.2 0.1 4.3 5 1 0 5 5 5 0 Tetratricopeptide repeat GPR15L PF15854.5 EFC45548.1 - 0.029 14.6 0.0 0.029 14.6 0.0 5.4 2 1 2 4 4 4 0 G-protein coupled receptor ligand 15 p450 PF00067.22 EFC45549.1 - 6.7e-65 219.6 0.1 7.8e-65 219.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1863 PF08937.11 EFC45549.1 - 0.0065 16.8 0.1 0.01 16.2 0.1 1.4 1 0 0 1 1 1 1 MTH538 TIR-like domain (DUF1863) DUF5387 PF17361.2 EFC45549.1 - 0.0098 15.6 0.2 0.014 15.1 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5387) SGL PF08450.12 EFC45550.1 - 0.0091 15.6 0.0 0.044 13.4 0.0 2.0 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC45550.1 - 0.033 14.4 0.1 0.27 11.4 0.0 2.4 1 1 1 2 2 2 0 Arylesterase Actin PF00022.19 EFC45551.1 - 2.1e-145 484.4 0.0 8.3e-145 482.4 0.0 1.7 1 1 0 1 1 1 1 Actin RGS PF00615.19 EFC45552.1 - 3.2e-12 46.7 1.4 5.3e-12 46.1 1.4 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC45552.1 - 0.0059 16.3 0.7 0.011 15.4 0.7 1.5 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain EF-hand_7 PF13499.6 EFC45553.1 - 6.1e-20 71.5 0.6 1.3e-09 38.4 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC45553.1 - 2.9e-19 67.1 1.3 4.3e-06 25.9 0.0 4.1 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EFC45553.1 - 6.1e-18 63.2 2.0 1.2e-06 27.9 0.1 4.5 3 1 1 4 4 4 2 EF-hand domain EF-hand_9 PF14658.6 EFC45553.1 - 7.4e-15 55.0 0.1 5.4e-08 33.1 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFC45553.1 - 1.5e-08 34.4 5.8 0.00051 19.8 0.0 3.8 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 EFC45553.1 - 2.6e-08 33.0 3.6 0.00011 21.5 0.2 2.9 3 0 0 3 3 3 2 EF hand DUF5580 PF17743.1 EFC45553.1 - 0.08 11.5 0.0 0.091 11.3 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EIAV_Rev PF11129.8 EFC45554.1 - 0.054 13.7 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Rev protein of equine infectious anaemia virus DUF848 PF05852.11 EFC45554.1 - 1.3 9.2 7.4 0.41 10.8 2.5 2.4 3 0 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) LRR_4 PF12799.7 EFC45555.1 - 9.2e-26 89.5 33.1 1.6e-06 28.3 0.4 8.7 4 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC45555.1 - 8e-25 84.7 30.1 6.3e-05 22.7 1.2 12.5 13 0 0 13 13 13 9 Leucine Rich repeat LRR_8 PF13855.6 EFC45555.1 - 1.9e-16 59.6 30.1 2.1e-06 27.4 2.4 7.1 5 2 3 8 8 8 6 Leucine rich repeat LRR_1 PF00560.33 EFC45555.1 - 2.6e-07 30.2 26.0 6.3 7.8 0.1 10.7 11 1 0 11 11 11 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC45555.1 - 1.5e-05 24.6 7.6 0.18 11.3 1.3 3.8 1 1 3 4 4 4 3 Leucine-rich repeat LRR_2 PF07723.13 EFC45555.1 - 0.18 12.5 4.2 20 6.1 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat RGS PF00615.19 EFC45556.1 - 0.00018 21.8 1.2 0.00018 21.8 1.2 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain Lectin_N PF03954.14 EFC45556.1 - 0.29 10.9 3.8 8 6.2 0.1 2.9 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain tRNA-Thr_ED PF08915.11 EFC45557.1 - 0.085 12.9 1.4 0.24 11.5 1.4 1.8 1 1 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase F-box-like PF12937.7 EFC45559.1 - 4.7e-07 29.6 0.0 1.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC45559.1 - 0.0013 18.6 0.0 0.0037 17.1 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ribonuclease_T2 PF00445.18 EFC45561.1 - 1.3e-41 142.9 0.0 1.5e-41 142.7 0.0 1.0 1 0 0 1 1 1 1 Ribonuclease T2 family ATP-synt_J PF04911.12 EFC45561.1 - 0.03 13.9 0.2 0.49 10.0 0.0 2.3 2 1 0 2 2 2 0 ATP synthase j chain EF1G PF00647.19 EFC45561.1 - 0.11 12.6 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain VIT1 PF01988.19 EFC45562.1 - 8.9 6.1 6.0 3.1 7.6 1.9 2.0 1 1 1 2 2 2 0 VIT family DrrA_P4M PF14860.6 EFC45563.1 - 0.026 14.4 0.5 0.074 12.9 0.1 1.9 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain RCC1 PF00415.18 EFC45564.1 - 1.1e-54 182.8 4.2 7.4e-11 42.5 0.0 8.2 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45564.1 - 3.1e-44 147.9 23.7 1.7e-10 40.4 0.1 7.3 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC45564.1 - 0.0034 17.6 3.6 23 5.3 0.0 5.2 3 2 2 5 5 5 1 Putative heavy-metal chelation GAS2 PF02187.17 EFC45565.1 - 0.0028 17.7 0.0 0.014 15.5 0.1 2.1 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain Formin_GBD_N PF18382.1 EFC45565.1 - 0.066 13.7 0.1 1 9.8 0.0 3.0 2 0 0 2 2 2 0 Formin N-terminal GTPase-binding domain RNase_E_G PF10150.9 EFC45565.1 - 0.29 10.5 3.4 3.2 7.1 0.3 2.4 1 1 1 2 2 2 0 Ribonuclease E/G family Myb_DNA-binding PF00249.31 EFC45567.1 - 1e-26 92.9 10.2 2.3e-13 50.1 0.7 2.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC45567.1 - 7.5e-20 70.9 9.5 1e-14 54.5 2.9 2.0 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC45567.1 - 0.00068 19.5 2.1 0.27 11.2 0.5 2.1 2 0 0 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 EFC45567.1 - 0.00087 19.3 0.1 1.2 9.2 0.0 2.1 1 1 1 2 2 2 2 SLIDE Myb_DNA-bind_4 PF13837.6 EFC45567.1 - 0.025 15.0 8.0 2.8 8.4 3.6 2.9 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF722 PF05263.11 EFC45567.1 - 0.13 12.5 0.6 1.3 9.3 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF722) LRR_6 PF13516.6 EFC45568.1 - 1.9e-19 68.0 31.3 2.3e-06 27.2 0.1 11.3 12 0 0 12 12 12 5 Leucine Rich repeat LRR_4 PF12799.7 EFC45568.1 - 4.4e-13 49.2 28.9 0.017 15.5 0.4 8.2 4 2 6 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45568.1 - 2.3e-06 27.3 18.1 0.00038 20.1 0.9 6.3 4 2 4 8 8 8 4 Leucine rich repeat LRR_1 PF00560.33 EFC45568.1 - 6.7e-05 22.9 16.4 23 6.1 0.0 9.7 9 2 1 10 10 10 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC45568.1 - 0.0023 17.5 2.0 0.12 11.8 0.2 2.5 2 1 0 2 2 2 2 Leucine-rich repeat FTH PF01827.27 EFC45568.1 - 0.091 12.6 0.2 10 5.9 0.0 3.3 2 1 1 3 3 3 0 FTH domain EFhand_Ca_insen PF08726.10 EFC45568.1 - 0.19 11.9 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 Ca2+ insensitive EF hand LNS2 PF08235.13 EFC45569.1 - 2.1e-94 315.2 0.0 3.2e-94 314.6 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 EFC45569.1 - 9.3e-32 109.0 0.0 2.3e-31 107.8 0.0 1.7 1 0 0 1 1 1 1 lipin, N-terminal conserved region WRNPLPNID PF15017.6 EFC45569.1 - 0.071 14.0 0.8 0.071 14.0 0.8 2.9 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box zf-C2H2_12 PF18658.1 EFC45570.1 - 0.0032 17.0 0.1 0.0063 16.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger C2H2-type OppC_N PF12911.7 EFC45572.1 - 0.4 10.7 2.9 2.3 8.3 0.4 2.7 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C EI24 PF07264.11 EFC45572.1 - 0.59 10.4 4.5 2.3 8.5 3.8 2.2 2 1 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) DUF4389 PF14333.6 EFC45572.1 - 6.6 6.7 7.2 3.4 7.7 4.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) TMEM37 PF15108.6 EFC45573.1 - 0.091 12.6 0.4 3.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent calcium channel gamma-like subunit protein family DUF3666 PF12408.8 EFC45574.1 - 0.081 12.1 0.0 0.26 10.5 0.0 1.9 1 1 1 2 2 2 0 Ribose-5-phosphate isomerase ATP-synt_8 PF00895.20 EFC45574.1 - 0.67 10.4 5.5 4.9 7.7 5.5 2.5 1 0 0 1 1 1 0 ATP synthase protein 8 DUF4713 PF15831.5 EFC45574.1 - 2.7 8.5 5.1 6.7 7.2 5.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Suv3_N PF18114.1 EFC45575.1 - 0.022 14.8 0.6 0.074 13.2 0.6 1.9 1 0 0 1 1 1 0 Suv3 helical N-terminal domain STE3 PF02076.15 EFC45575.1 - 0.036 13.3 1.4 0.18 11.0 0.4 2.1 2 0 0 2 2 2 0 Pheromone A receptor p450 PF00067.22 EFC45576.1 - 3.7e-76 256.7 0.2 4.5e-76 256.5 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2179 PF10035.9 EFC45577.1 - 1.8 8.4 4.1 1.1 9.0 0.8 2.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2179) Dynactin_p62 PF05502.13 EFC45578.1 - 6.4e-07 28.5 18.3 6e-06 25.3 14.3 3.7 3 1 1 4 4 4 2 Dynactin p62 family RNA_pol_Rpb5_N PF03871.14 EFC45578.1 - 0.14 12.7 0.7 0.68 10.5 0.7 2.2 1 0 0 1 1 1 0 RNA polymerase Rpb5, N-terminal domain PEP-utilizers_C PF02896.18 EFC45580.1 - 2.5e-89 299.3 0.7 4.1e-89 298.6 0.7 1.3 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 EFC45580.1 - 2e-57 194.9 0.1 2.8e-44 151.7 0.0 2.3 1 1 1 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 EFC45580.1 - 1.7e-22 78.9 1.6 3.1e-22 78.1 0.4 2.1 2 0 0 2 2 2 1 PEP-utilising enzyme, mobile domain HTH_48 PF17906.1 EFC45580.1 - 0.057 13.5 0.1 5.8 7.1 0.0 3.2 2 0 0 2 2 2 0 HTH domain in Mos1 transposase Phage_sheath_1C PF17482.2 EFC45580.1 - 0.077 13.0 0.3 9.5 6.3 0.0 2.8 2 0 0 2 2 2 0 Phage tail sheath C-terminal domain DUF2262 PF10020.9 EFC45580.1 - 1 9.7 5.7 0.23 11.8 0.1 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2262) EF-hand_6 PF13405.6 EFC45581.1 - 1.1e-19 68.5 10.9 1.6e-07 30.7 0.2 3.8 3 1 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 EFC45581.1 - 1.1e-19 68.4 17.5 1.6e-07 30.4 0.5 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC45581.1 - 2.9e-19 69.3 12.0 1.1e-13 51.4 2.0 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC45581.1 - 1e-14 53.3 11.1 1e-06 27.9 0.2 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFC45581.1 - 9.9e-10 38.1 19.2 0.00038 20.3 2.5 4.2 2 1 3 5 5 5 3 EF-hand domain pair EF-hand_9 PF14658.6 EFC45581.1 - 1e-09 38.6 0.5 8.7e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC45581.1 - 0.00072 19.9 2.3 0.87 9.9 0.0 2.7 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC45581.1 - 0.0025 17.7 9.5 0.015 15.3 1.1 2.8 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 EFC45581.1 - 0.0064 16.4 0.2 0.7 9.8 0.0 2.6 2 1 1 3 3 3 1 Caleosin related protein TerB PF05099.13 EFC45581.1 - 0.016 15.1 0.1 0.76 9.7 0.0 2.4 2 1 0 2 2 2 0 Tellurite resistance protein TerB ATPgrasp_N PF18130.1 EFC45581.1 - 0.019 15.5 0.2 0.085 13.4 0.1 1.9 2 0 0 2 2 2 0 ATP-grasp N-terminal domain EF-hand_14 PF17959.1 EFC45581.1 - 0.034 14.5 1.5 2.1 8.7 0.1 2.5 2 1 0 2 2 2 0 EF-hand domain Prefoldin_3 PF13758.6 EFC45581.1 - 0.061 13.4 0.7 12 6.0 0.1 2.6 1 1 1 2 2 2 0 Prefoldin subunit EF-hand_11 PF08976.11 EFC45581.1 - 0.062 14.2 0.3 0.45 11.4 0.0 2.0 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 EFC45581.1 - 0.26 11.5 5.2 4.2 7.6 0.1 2.6 3 0 0 3 3 3 0 Dockerin type I domain Memo PF01875.17 EFC45582.1 - 4.3e-73 245.8 0.7 4.9e-73 245.6 0.7 1.0 1 0 0 1 1 1 1 Memo-like protein Dzip-like_N PF13815.6 EFC45583.1 - 5.8e-23 81.1 1.7 5.8e-23 81.1 1.7 1.5 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal Flu_M1_C PF08289.11 EFC45584.1 - 0.53 10.5 4.9 3.8 7.8 0.0 3.4 3 1 1 4 4 4 0 Influenza Matrix protein (M1) C-terminal domain Transglut_core PF01841.19 EFC45585.1 - 2.8e-11 43.9 0.0 1.7e-10 41.3 0.1 2.3 2 1 0 2 2 2 1 Transglutaminase-like superfamily HSP70 PF00012.20 EFC45585.1 - 6e-09 34.6 6.5 1.2e-05 23.7 0.0 3.0 2 1 1 3 3 3 2 Hsp70 protein DUF553 PF04473.12 EFC45585.1 - 2.1e-06 27.4 3.2 3.4e-06 26.7 0.1 2.8 3 1 0 3 3 3 1 Transglutaminase-like domain MreB_Mbl PF06723.13 EFC45585.1 - 0.00014 20.8 1.7 0.058 12.2 0.3 2.5 2 1 0 2 2 2 2 MreB/Mbl protein PilM_2 PF11104.8 EFC45585.1 - 0.00019 20.6 0.4 0.00076 18.6 0.3 2.0 2 0 0 2 2 2 1 Type IV pilus assembly protein PilM; BcrAD_BadFG PF01869.20 EFC45585.1 - 0.0064 16.0 0.5 0.014 14.9 0.5 1.6 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Propep_M14 PF02244.16 EFC45585.1 - 0.031 14.7 0.1 0.46 10.9 0.1 2.6 2 0 0 2 2 2 0 Carboxypeptidase activation peptide AAA_16 PF13191.6 EFC45586.1 - 0.00013 22.4 0.0 0.00022 21.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 EFC45586.1 - 0.00025 21.1 0.0 0.00056 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 EFC45586.1 - 0.0012 18.8 0.0 0.0058 16.6 0.0 2.2 2 1 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 EFC45586.1 - 0.0061 16.5 2.4 0.014 15.3 1.7 2.0 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 EFC45586.1 - 0.0079 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 EFC45586.1 - 0.015 15.8 0.0 0.07 13.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFC45586.1 - 0.031 14.7 0.1 0.086 13.3 0.1 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ADIP PF11559.8 EFC45587.1 - 4.7e-13 49.5 18.3 4.7e-13 49.5 18.3 2.9 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding ERM PF00769.19 EFC45587.1 - 0.0006 19.7 21.3 0.0006 19.7 21.3 1.6 2 0 0 2 2 2 1 Ezrin/radixin/moesin family ATG16 PF08614.11 EFC45587.1 - 0.17 12.1 24.5 0.15 12.3 15.5 2.9 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Uso1_p115_C PF04871.13 EFC45587.1 - 0.35 11.2 24.7 3.5 8.0 0.4 2.9 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Peptidase_S30 PF01577.16 EFC45587.1 - 0.52 9.9 9.0 0.94 9.0 9.0 1.4 1 0 0 1 1 1 0 Potyvirus P1 protease Spc7 PF08317.11 EFC45587.1 - 0.61 8.9 28.0 1.4 7.7 19.4 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 EFC45587.1 - 1.6 9.0 27.5 9.8 6.4 0.3 3.2 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 GAS PF13851.6 EFC45587.1 - 3.9 6.8 37.2 0.065 12.6 1.1 3.1 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 EFC45587.1 - 6.8 5.9 21.8 2 7.7 11.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) FapA PF03961.13 EFC45587.1 - 9.5 4.7 20.1 14 4.2 0.3 2.3 2 0 0 2 2 2 0 Flagellar Assembly Protein A BLOC1_2 PF10046.9 EFC45587.1 - 9.7 6.6 23.5 1.6 9.1 7.6 3.8 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Methyltransf_16 PF10294.9 EFC45588.1 - 4.5e-12 46.1 0.0 6.1e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 EFC45588.1 - 2.7e-09 37.1 0.0 3.8e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC45588.1 - 2.5e-08 33.9 0.2 1.3e-07 31.6 0.2 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC45588.1 - 4.5e-06 27.3 0.0 1.5e-05 25.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC45588.1 - 5e-06 27.1 0.0 1.1e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC45588.1 - 2.2e-05 25.0 0.0 6.1e-05 23.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC45588.1 - 0.058 12.7 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF1643 PF07799.12 EFC45588.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) ELMO_CED12 PF04727.13 EFC45589.1 - 4.9e-23 82.1 3.5 8.5e-22 78.1 0.9 2.2 2 0 0 2 2 2 2 ELMO/CED-12 family Cas6_N PF17952.1 EFC45589.1 - 0.0067 16.7 2.0 0.011 16.1 0.6 2.1 2 0 0 2 2 2 1 Cas6 N-terminal domain RAMPs PF03787.15 EFC45589.1 - 0.04 13.9 0.5 0.24 11.4 0.5 2.0 1 1 1 2 2 2 0 RAMP superfamily BBP2 PF07642.11 EFC45589.1 - 0.082 12.0 0.4 0.13 11.4 0.4 1.3 1 1 0 1 1 1 0 Putative beta-barrel porin-2, OmpL-like. bbp2 TPT PF03151.16 EFC45590.1 - 8.2e-29 100.9 30.5 1e-28 100.6 30.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC45590.1 - 1.2e-06 28.8 30.7 0.0014 18.8 12.1 2.3 2 0 0 2 2 2 2 EamA-like transporter family Ras PF00071.22 EFC45591.1 - 4e-12 46.0 0.0 4.2e-06 26.5 0.0 2.3 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 EFC45591.1 - 5.2e-10 39.4 0.0 0.00044 20.3 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC45591.1 - 1.5e-09 37.7 0.0 0.014 14.9 0.0 3.9 3 1 1 4 4 4 2 Elongation factor Tu GTP binding domain Roc PF08477.13 EFC45591.1 - 9e-09 35.6 0.0 2.9e-05 24.3 0.0 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45591.1 - 1.1e-06 28.2 0.0 7.8e-05 22.2 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family ATPase_2 PF01637.18 EFC45591.1 - 5.5e-06 26.5 0.4 0.06 13.3 0.0 2.5 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea EF_assoc_2 PF08356.12 EFC45591.1 - 3.4e-05 23.7 0.0 8.8e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 EF hand associated EF-hand_6 PF13405.6 EFC45591.1 - 5.2e-05 22.9 1.6 0.0016 18.2 0.7 3.7 4 0 0 4 4 3 1 EF-hand domain RsgA_GTPase PF03193.16 EFC45591.1 - 5.7e-05 23.1 0.0 0.085 12.8 0.0 3.9 4 0 0 4 4 4 1 RsgA GTPase EF-hand_1 PF00036.32 EFC45591.1 - 8.6e-05 21.8 4.1 0.0042 16.5 0.7 4.3 4 0 0 4 4 4 1 EF hand TniB PF05621.11 EFC45591.1 - 0.00015 21.3 0.1 0.023 14.1 0.0 3.0 3 1 0 3 3 3 1 Bacterial TniB protein SRPRB PF09439.10 EFC45591.1 - 0.00035 20.1 0.1 0.37 10.2 0.1 2.7 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit EF-hand_7 PF13499.6 EFC45591.1 - 0.00091 19.6 5.7 0.016 15.7 0.2 3.7 4 1 0 4 4 2 1 EF-hand domain pair Dynamin_N PF00350.23 EFC45591.1 - 0.0017 18.4 0.1 1.5 8.9 0.0 2.8 2 1 0 2 2 2 1 Dynamin family G-alpha PF00503.20 EFC45591.1 - 0.0018 17.5 0.4 0.86 8.7 0.0 2.9 2 1 0 3 3 3 1 G-protein alpha subunit EF-hand_8 PF13833.6 EFC45591.1 - 0.003 17.4 5.2 0.014 15.3 1.2 3.3 3 0 0 3 3 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC45591.1 - 0.0034 17.7 1.2 0.011 16.1 1.2 1.8 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region AAA_29 PF13555.6 EFC45591.1 - 0.0035 17.1 0.0 0.03 14.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 EFC45591.1 - 0.0049 17.1 0.1 1.6 9.0 0.0 3.3 2 2 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFC45591.1 - 0.0055 16.5 0.0 2.7 7.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFC45591.1 - 0.013 16.0 0.0 4.6 7.7 0.0 2.5 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 EFC45591.1 - 0.025 14.9 0.0 7.5 7.0 0.0 3.2 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 EFC45591.1 - 0.047 13.6 0.4 1.5 8.7 0.1 2.9 3 1 0 3 3 3 0 NTPase AAA_16 PF13191.6 EFC45591.1 - 0.051 13.9 0.0 2.7 8.3 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 EFC45591.1 - 0.16 11.3 0.0 3.5 6.9 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family FeoB_N PF02421.18 EFC45591.1 - 0.16 11.5 0.0 16 5.0 0.0 2.8 2 1 0 2 2 2 0 Ferrous iron transport protein B AAA_28 PF13521.6 EFC45591.1 - 0.19 12.0 0.0 25 5.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain EF-hand_5 PF13202.6 EFC45591.1 - 1.8 8.2 8.4 3.7 7.2 2.1 3.5 3 0 0 3 3 3 0 EF hand TruB_N PF01509.18 EFC45592.1 - 4.2e-26 92.1 0.1 9.4e-20 71.5 0.0 2.5 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 EFC45592.1 - 0.038 14.1 0.1 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain Med26_C PF15693.5 EFC45592.1 - 0.084 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal EGF_3 PF12947.7 EFC45592.1 - 1 9.6 3.9 0.51 10.6 0.5 2.3 3 0 0 3 3 3 0 EGF domain Actin PF00022.19 EFC45593.1 - 8.1e-93 311.2 0.0 4.8e-46 157.2 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFC45593.1 - 0.0056 15.6 0.0 0.089 11.6 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DNA_primase_lrg PF04104.14 EFC45593.1 - 0.011 15.2 0.1 3.5 7.0 0.0 2.5 2 1 1 3 3 3 0 Eukaryotic and archaeal DNA primase, large subunit Ank_2 PF12796.7 EFC45594.1 - 2.2e-15 57.0 0.6 2e-05 25.1 0.1 3.4 2 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC45594.1 - 2.6e-13 48.9 1.1 0.069 13.7 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 EFC45594.1 - 5.3e-12 45.7 2.7 0.02 15.2 0.0 5.0 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC45594.1 - 3.2e-08 33.7 0.2 1 9.9 0.0 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFC45594.1 - 1.9e-07 31.5 0.5 1 10.0 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) LPD24 PF18839.1 EFC45594.1 - 0.45 10.8 2.3 1.9 8.8 0.1 2.5 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 DUF3452 PF11934.8 EFC45595.1 - 0.018 14.6 0.9 0.049 13.2 0.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) DUF3584 PF12128.8 EFC45596.1 - 0.00024 18.8 19.4 0.00027 18.6 19.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Tektin PF03148.14 EFC45596.1 - 0.00054 18.8 22.0 0.033 12.9 8.8 2.0 1 1 1 2 2 2 2 Tektin family FapA PF03961.13 EFC45596.1 - 0.00082 18.1 14.8 0.00092 17.9 14.8 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A Baculo_PEP_C PF04513.12 EFC45596.1 - 0.0016 18.5 7.3 0.0046 17.0 7.3 1.7 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 EFC45596.1 - 0.0028 17.3 22.4 0.11 12.0 9.8 2.1 1 1 1 2 2 2 2 PspA/IM30 family Myosin_tail_1 PF01576.19 EFC45596.1 - 0.0031 15.4 22.2 0.0037 15.2 22.2 1.1 1 0 0 1 1 1 1 Myosin tail Apolipoprotein PF01442.18 EFC45596.1 - 0.0041 17.0 19.9 0.036 13.9 17.0 2.3 1 1 1 2 2 2 1 Apolipoprotein A1/A4/E domain MAP65_ASE1 PF03999.12 EFC45596.1 - 0.014 14.1 19.0 0.019 13.7 18.7 1.3 1 1 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Golgin_A5 PF09787.9 EFC45596.1 - 0.02 14.4 26.0 0.45 9.9 12.4 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 5 Filament PF00038.21 EFC45596.1 - 0.023 14.3 24.4 0.04 13.5 24.4 1.4 1 1 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.10 EFC45596.1 - 0.024 14.8 19.0 0.054 13.7 19.0 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Tmemb_cc2 PF10267.9 EFC45596.1 - 0.025 13.7 22.9 0.043 13.0 22.9 1.4 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF5082 PF16888.5 EFC45596.1 - 0.025 14.8 18.5 0.11 12.8 7.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) MscS_porin PF12795.7 EFC45596.1 - 0.029 13.9 21.9 0.038 13.5 21.9 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain FAM184 PF15665.5 EFC45596.1 - 0.029 14.2 21.6 0.036 13.8 21.6 1.1 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B Spc7 PF08317.11 EFC45596.1 - 0.032 13.1 24.1 0.045 12.6 24.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein COG5 PF10392.9 EFC45596.1 - 0.035 14.3 7.2 0.054 13.7 7.2 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Tropomyosin PF00261.20 EFC45596.1 - 0.035 13.5 21.4 0.43 9.9 4.0 2.2 1 1 1 2 2 2 0 Tropomyosin KxDL PF10241.9 EFC45596.1 - 0.043 14.1 15.9 0.59 10.4 4.4 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein DUF4407 PF14362.6 EFC45596.1 - 0.046 13.1 16.3 0.057 12.8 16.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 5_nucleotid PF05761.14 EFC45596.1 - 0.047 12.6 10.6 0.057 12.3 10.6 1.0 1 0 0 1 1 1 0 5' nucleotidase family Uso1_p115_C PF04871.13 EFC45596.1 - 0.052 13.9 26.4 0.97 9.8 26.8 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1664 PF07889.12 EFC45596.1 - 0.055 13.5 12.8 4 7.5 12.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Fungal_TACC PF12709.7 EFC45596.1 - 0.058 13.9 29.5 0.15 12.5 7.4 2.8 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins 7TMR-HDED PF07697.11 EFC45596.1 - 0.061 13.4 11.7 0.07 13.2 11.7 1.0 1 0 0 1 1 1 0 7TM-HD extracellular Tweety PF04906.13 EFC45596.1 - 0.068 11.8 3.5 0.079 11.6 3.5 1.1 1 0 0 1 1 1 0 Tweety MICSWaP PF17018.5 EFC45596.1 - 0.074 12.6 6.6 0.025 14.1 3.2 1.9 1 1 1 2 2 2 0 Spore wall protein DUF724 PF05266.14 EFC45596.1 - 0.077 12.8 23.2 0.072 12.9 4.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) AAA_13 PF13166.6 EFC45596.1 - 0.086 11.5 16.0 0.13 10.8 16.0 1.3 1 0 0 1 1 1 0 AAA domain PEPcase PF00311.17 EFC45596.1 - 0.12 10.4 12.0 0.14 10.2 12.0 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Mitofilin PF09731.9 EFC45596.1 - 0.12 11.1 21.0 0.15 10.9 21.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein MAD PF05557.13 EFC45596.1 - 0.13 10.6 24.1 0.16 10.3 24.1 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein EzrA PF06160.12 EFC45596.1 - 0.2 9.8 21.3 0.27 9.4 21.3 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Phage_Mu_Gam PF07352.12 EFC45596.1 - 0.21 11.5 27.3 1.5 8.7 8.3 2.6 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein Exonuc_VII_L PF02601.15 EFC45596.1 - 0.23 11.0 16.2 0.27 10.8 16.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5344 PF17279.2 EFC45596.1 - 0.25 11.9 16.8 4.4 7.9 15.2 2.5 1 1 0 1 1 1 0 Family of unknown function (DUF5344) PIN_8 PF18476.1 EFC45596.1 - 0.28 11.0 14.2 0.34 10.7 14.2 1.1 1 0 0 1 1 1 0 PIN like domain XhlA PF10779.9 EFC45596.1 - 0.28 11.4 19.5 0.68 10.2 2.2 3.0 1 1 2 3 3 3 0 Haemolysin XhlA TPR_MLP1_2 PF07926.12 EFC45596.1 - 0.32 11.1 30.3 7.8 6.6 30.2 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 EFC45596.1 - 0.37 10.1 26.3 0.51 9.6 12.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 EFC45596.1 - 0.38 10.8 29.9 0.48 10.5 29.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus IFT57 PF10498.9 EFC45596.1 - 0.46 9.4 21.6 0.59 9.0 21.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF4795 PF16043.5 EFC45596.1 - 0.49 10.0 20.9 11 5.6 20.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Tropomyosin_1 PF12718.7 EFC45596.1 - 0.52 10.5 31.3 13 6.0 31.3 2.4 1 1 0 1 1 1 0 Tropomyosin like DUF641 PF04859.12 EFC45596.1 - 0.56 10.5 20.2 1.3 9.4 9.4 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Cob_adeno_trans PF01923.18 EFC45596.1 - 0.57 10.3 9.7 8.3 6.5 9.7 2.1 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Nas2_N PF18265.1 EFC45596.1 - 0.59 10.1 18.6 1.3 9.0 1.2 3.7 1 1 3 4 4 4 0 Nas2 N_terminal domain AI-2E_transport PF01594.16 EFC45596.1 - 0.59 9.2 1.7 0.79 8.8 1.7 1.4 1 1 0 1 1 1 0 AI-2E family transporter SHE3 PF17078.5 EFC45596.1 - 0.64 9.7 23.3 18 4.9 23.5 2.0 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 EAP30 PF04157.16 EFC45596.1 - 0.64 9.3 14.5 0.15 11.3 3.7 2.0 1 1 1 2 2 2 0 EAP30/Vps36 family OTU PF02338.19 EFC45596.1 - 0.69 10.4 8.5 1.8 9.1 8.4 1.8 1 1 0 1 1 1 0 OTU-like cysteine protease TMPIT PF07851.13 EFC45596.1 - 0.71 9.1 21.3 0.66 9.2 5.7 2.0 1 1 1 2 2 2 0 TMPIT-like protein CALCOCO1 PF07888.11 EFC45596.1 - 0.73 8.6 21.7 0.86 8.4 21.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Remorin_C PF03763.13 EFC45596.1 - 0.74 9.7 21.2 0.1 12.4 12.3 2.6 1 1 1 2 2 2 0 Remorin, C-terminal region Kri1 PF05178.12 EFC45596.1 - 0.76 10.4 18.5 1.1 9.8 18.5 1.4 1 0 0 1 1 1 0 KRI1-like family Sec34 PF04136.15 EFC45596.1 - 0.8 9.6 16.0 1.3 8.9 11.0 2.0 1 1 1 2 2 2 0 Sec34-like family FPP PF05911.11 EFC45596.1 - 0.84 7.8 22.9 0.98 7.5 22.9 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Prefoldin_2 PF01920.20 EFC45596.1 - 0.94 9.5 31.7 5.3 7.1 15.0 3.2 1 1 1 2 2 2 0 Prefoldin subunit FlxA PF14282.6 EFC45596.1 - 0.95 9.5 27.8 7.5 6.6 0.3 2.4 1 1 1 2 2 2 0 FlxA-like protein Stathmin PF00836.19 EFC45596.1 - 0.95 9.4 25.1 0.23 11.4 10.8 2.4 1 1 1 2 2 2 0 Stathmin family ApoO PF09769.9 EFC45596.1 - 1 9.4 9.8 0.35 10.8 4.1 2.0 1 1 1 2 2 2 0 Apolipoprotein O ATG16 PF08614.11 EFC45596.1 - 1 9.5 24.2 2.6 8.2 13.9 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BshC PF10079.9 EFC45596.1 - 1.1 7.9 15.0 1.7 7.3 15.0 1.3 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC DUF812 PF05667.11 EFC45596.1 - 1.2 8.0 24.2 1.7 7.4 24.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF2252 PF10009.9 EFC45596.1 - 1.2 8.2 5.8 1.3 8.1 5.8 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) DUF2935 PF11155.8 EFC45596.1 - 1.2 9.4 12.6 0.16 12.3 6.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) OmpH PF03938.14 EFC45596.1 - 1.3 9.4 34.7 25 5.2 29.4 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) dCache_3 PF14827.6 EFC45596.1 - 1.3 8.6 6.7 0.11 12.2 1.2 1.8 2 1 0 2 2 2 0 Double sensory domain of two-component sensor kinase DUF4200 PF13863.6 EFC45596.1 - 1.4 9.3 30.3 3 8.2 6.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4446 PF14584.6 EFC45596.1 - 1.5 8.7 18.3 0.26 11.3 4.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Tup_N PF08581.10 EFC45596.1 - 1.6 9.1 29.8 0.87 9.9 0.8 3.7 1 1 2 3 3 2 0 Tup N-terminal HalX PF08663.10 EFC45596.1 - 1.6 9.1 18.5 3.5 8.0 9.5 3.1 1 1 1 2 2 2 0 HalX domain Atg14 PF10186.9 EFC45596.1 - 1.9 7.5 17.2 3 6.9 17.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 EFC45596.1 - 2.2 8.5 26.8 3.4 7.9 24.1 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 V_ATPase_I PF01496.19 EFC45596.1 - 2.5 5.9 15.2 2.7 5.8 15.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Swi5 PF07061.11 EFC45596.1 - 2.5 8.3 25.2 9.4 6.4 0.2 3.7 1 1 1 2 2 1 0 Swi5 ZYG-11_interact PF05884.12 EFC45596.1 - 2.5 7.4 7.2 3 7.2 7.2 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 NPV_P10 PF05531.12 EFC45596.1 - 2.9 8.4 10.0 3.8e+02 1.6 10.0 2.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Allexi_40kDa PF05549.11 EFC45596.1 - 2.9 7.3 9.0 8.5 5.8 9.0 1.7 1 1 0 1 1 1 0 Allexivirus 40kDa protein SpecificRecomb PF10136.9 EFC45596.1 - 2.9 6.1 4.7 3.3 5.9 4.7 1.0 1 0 0 1 1 1 0 Site-specific recombinase DUF3573 PF12097.8 EFC45596.1 - 3 6.6 7.4 4.3 6.0 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) TetR_C_24 PF17932.1 EFC45596.1 - 3.1 8.1 6.6 7 7.0 2.0 2.5 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RHD3 PF05879.12 EFC45596.1 - 3.2 5.8 13.3 3.6 5.6 13.3 1.0 1 0 0 1 1 1 0 Root hair defective 3 GTP-binding protein (RHD3) ADIP PF11559.8 EFC45596.1 - 3.3 7.8 25.3 22 5.1 16.4 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ZnuA PF01297.17 EFC45596.1 - 3.4 7.0 16.3 2.1 7.7 4.5 2.2 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic YlqD PF11068.8 EFC45596.1 - 3.4 8.0 24.7 5.4 7.4 21.2 2.0 1 1 1 2 2 2 0 YlqD protein FlaC_arch PF05377.11 EFC45596.1 - 3.9 7.9 15.6 17 5.9 5.7 3.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF1943 PF09172.11 EFC45596.1 - 3.9 6.6 13.7 2.7 7.1 12.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1943) DUF16 PF01519.16 EFC45596.1 - 4 8.0 23.0 1.2 9.7 5.8 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 SKA1 PF07160.12 EFC45596.1 - 4.5 7.0 18.0 8.4 6.2 8.8 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 LMBR1 PF04791.16 EFC45596.1 - 5.5 5.8 14.4 6.2 5.6 14.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Hrs_helical PF12210.8 EFC45596.1 - 5.8 7.5 19.6 6.8 7.3 4.4 2.5 1 1 2 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Syntaxin-6_N PF09177.11 EFC45596.1 - 6.1 7.5 14.5 11 6.7 3.2 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HSP70 PF00012.20 EFC45596.1 - 6.2 4.9 17.5 8.1 4.5 17.5 1.1 1 0 0 1 1 1 0 Hsp70 protein HemX PF04375.14 EFC45596.1 - 7 5.8 22.6 53 2.9 22.6 1.9 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CREPT PF16566.5 EFC45596.1 - 7.4 6.7 19.1 45 4.2 5.2 1.9 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour FoP_duplication PF13865.6 EFC45596.1 - 7.9 7.1 13.5 10 6.7 7.1 2.8 1 1 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 DUF948 PF06103.11 EFC45596.1 - 8.3 6.7 5.5 25 5.2 5.5 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Sec2p PF06428.11 EFC45596.1 - 9.7 6.2 25.6 15 5.7 12.0 2.7 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF4164 PF13747.6 EFC45598.1 - 0.003 17.8 10.7 0.003 17.8 10.7 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4164) DUF5354 PF17305.2 EFC45598.1 - 0.089 13.0 0.3 0.089 13.0 0.3 3.1 2 2 1 4 4 4 0 Family of unknown function (DUF5354) HOCHOB PF17943.1 EFC45599.1 - 0.00076 20.2 1.5 0.0026 18.5 0.2 2.1 2 0 0 2 2 2 1 Homeobox-cysteine loop-homeobox Rootletin PF15035.6 EFC45599.1 - 0.0057 16.7 5.5 0.0077 16.3 5.5 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DUF465 PF04325.13 EFC45599.1 - 0.022 14.8 3.6 0.043 13.9 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF465) YabA PF06156.13 EFC45599.1 - 0.46 11.1 13.1 0.26 11.9 10.5 2.0 2 1 0 2 2 2 0 Initiation control protein YabA Bap31_Bap29_C PF18035.1 EFC45599.1 - 1.9 8.5 8.7 3.9 7.6 8.7 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF724 PF05266.14 EFC45599.1 - 2 8.2 11.4 0.7 9.7 8.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) SSP160 PF06933.11 EFC45599.1 - 9 4.4 19.3 25 2.9 16.1 2.0 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 NHL PF01436.21 EFC45600.1 - 0.0032 17.4 5.4 0.0092 16.0 0.0 3.8 4 0 0 4 4 4 1 NHL repeat SGL PF08450.12 EFC45600.1 - 0.055 13.1 0.1 0.24 10.9 0.0 2.1 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC45600.1 - 0.16 12.2 5.9 0.87 9.8 0.5 4.1 3 2 2 5 5 5 0 Arylesterase Tmemb_cc2 PF10267.9 EFC45601.1 - 1.4e-05 24.4 6.2 1.7e-05 24.2 6.2 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein FapA PF03961.13 EFC45601.1 - 0.00093 17.9 6.8 0.0011 17.6 6.8 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A Filament PF00038.21 EFC45601.1 - 0.0016 18.1 8.8 0.0024 17.5 8.8 1.2 1 0 0 1 1 1 1 Intermediate filament protein Prominin PF05478.11 EFC45601.1 - 0.0038 15.3 4.8 0.0051 14.8 4.8 1.1 1 0 0 1 1 1 1 Prominin ARGLU PF15346.6 EFC45601.1 - 0.0071 16.2 10.4 0.0098 15.8 10.4 1.1 1 0 0 1 1 1 1 Arginine and glutamate-rich 1 Golgin_A5 PF09787.9 EFC45601.1 - 0.0082 15.6 12.1 0.012 15.2 12.1 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 GBP_C PF02841.14 EFC45601.1 - 0.009 15.5 9.5 0.013 14.9 9.5 1.2 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain AAA_23 PF13476.6 EFC45601.1 - 0.011 16.2 9.0 0.044 14.3 9.0 1.8 1 1 0 1 1 1 0 AAA domain UPF0242 PF06785.11 EFC45601.1 - 0.015 15.4 14.1 0.019 15.1 14.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 EFC45601.1 - 0.018 15.1 3.9 0.034 14.2 3.9 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 EFC45601.1 - 0.021 12.4 7.2 0.026 12.1 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Exonuc_VII_L PF02601.15 EFC45601.1 - 0.023 14.3 3.4 0.028 14.0 3.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Apolipoprotein PF01442.18 EFC45601.1 - 0.028 14.3 12.0 0.2 11.5 11.9 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Spherulin4 PF12138.8 EFC45601.1 - 0.042 13.5 0.3 0.058 13.0 0.3 1.1 1 0 0 1 1 1 0 Spherulation-specific family 4 Fib_alpha PF08702.10 EFC45601.1 - 0.047 13.9 10.0 0.095 12.9 10.0 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HemX PF04375.14 EFC45601.1 - 0.053 12.8 9.0 0.072 12.4 9.0 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase MICSWaP PF17018.5 EFC45601.1 - 0.064 12.8 4.2 0.038 13.5 2.0 1.8 2 0 0 2 2 1 0 Spore wall protein DUF2935 PF11155.8 EFC45601.1 - 0.069 13.5 3.8 0.13 12.6 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Spc7 PF08317.11 EFC45601.1 - 0.07 12.0 13.5 0.026 13.4 10.6 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein Tektin PF03148.14 EFC45601.1 - 0.074 11.8 11.9 0.18 10.5 11.9 1.6 1 1 0 1 1 1 0 Tektin family OTU PF02338.19 EFC45601.1 - 0.081 13.4 2.9 0.15 12.6 2.9 1.4 1 0 0 1 1 1 0 OTU-like cysteine protease RuvX PF03652.15 EFC45601.1 - 0.089 13.2 0.3 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 Holliday junction resolvase DUF3450 PF11932.8 EFC45601.1 - 0.12 11.7 11.6 0.17 11.2 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Tweety PF04906.13 EFC45601.1 - 0.12 11.0 1.9 0.16 10.6 1.9 1.2 1 0 0 1 1 1 0 Tweety Snapin_Pallidin PF14712.6 EFC45601.1 - 0.15 12.5 9.8 0.43 11.0 9.8 1.8 1 0 0 1 1 1 0 Snapin/Pallidin EAP30 PF04157.16 EFC45601.1 - 0.16 11.2 3.5 0.23 10.7 3.5 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family dCache_3 PF14827.6 EFC45601.1 - 0.17 11.5 1.2 0.33 10.6 1.2 1.5 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase FemAB PF02388.16 EFC45601.1 - 0.19 10.6 7.4 0.27 10.1 7.4 1.1 1 0 0 1 1 1 0 FemAB family DUF5082 PF16888.5 EFC45601.1 - 0.19 12.0 13.6 0.69 10.2 13.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) CENP-F_leu_zip PF10473.9 EFC45601.1 - 0.28 11.2 17.5 14 5.7 9.6 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4407 PF14362.6 EFC45601.1 - 0.3 10.4 4.6 0.41 10.0 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YtxH PF12732.7 EFC45601.1 - 0.3 11.6 5.2 19 5.9 5.2 2.5 1 1 0 1 1 1 0 YtxH-like protein ApoO PF09769.9 EFC45601.1 - 0.33 10.9 3.0 0.52 10.3 3.0 1.2 1 0 0 1 1 1 0 Apolipoprotein O XhlA PF10779.9 EFC45601.1 - 0.33 11.2 11.5 1.9 8.8 2.1 2.4 1 1 1 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 EFC45601.1 - 0.38 10.8 7.3 0.62 10.1 6.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Remorin_C PF03763.13 EFC45601.1 - 0.42 10.5 11.0 0.94 9.4 11.0 1.6 1 1 0 1 1 1 0 Remorin, C-terminal region Fmp27_WPPW PF10359.9 EFC45601.1 - 0.55 9.0 8.9 0.79 8.5 8.9 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SAM_KSR1 PF13543.6 EFC45601.1 - 0.77 9.9 8.4 0.5 10.5 5.8 1.9 1 1 1 2 2 1 0 SAM like domain present in kinase suppressor RAS 1 PspA_IM30 PF04012.12 EFC45601.1 - 0.81 9.2 13.8 2.2 7.8 6.8 2.1 1 1 1 2 2 2 0 PspA/IM30 family NPV_P10 PF05531.12 EFC45601.1 - 0.93 10.0 6.1 29 5.2 6.1 2.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 EFC45601.1 - 1.1 9.7 14.8 4.5 7.8 5.9 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF5344 PF17279.2 EFC45601.1 - 1.1 9.8 12.5 2.7 8.6 2.4 2.8 2 1 1 3 3 2 0 Family of unknown function (DUF5344) DUF4446 PF14584.6 EFC45601.1 - 1.3 9.0 10.4 4.4 7.3 7.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Dzip-like_N PF13815.6 EFC45601.1 - 1.4 8.9 12.3 0.84 9.6 0.8 2.3 1 1 1 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF4795 PF16043.5 EFC45601.1 - 2.3 7.7 13.8 5.1 6.6 13.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) FoP_duplication PF13865.6 EFC45601.1 - 2.5 8.7 7.2 35 5.0 7.2 2.1 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Ureide_permease PF07168.11 EFC45601.1 - 2.5 6.8 4.2 3.9 6.1 4.2 1.2 1 0 0 1 1 1 0 Ureide permease Prefoldin PF02996.17 EFC45601.1 - 2.6 8.0 13.8 17 5.4 3.1 3.1 2 1 1 3 3 3 0 Prefoldin subunit Cob_adeno_trans PF01923.18 EFC45601.1 - 2.6 8.1 4.9 22 5.1 5.0 2.1 1 1 0 1 1 1 0 Cobalamin adenosyltransferase DUF724 PF05266.14 EFC45601.1 - 2.7 7.8 14.0 0.27 11.0 4.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF2203 PF09969.9 EFC45601.1 - 3.5 8.4 7.8 9.4 7.0 7.8 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Fzo_mitofusin PF04799.13 EFC45601.1 - 4.1 6.9 8.6 9.2 5.8 8.5 1.6 1 1 0 1 1 1 0 fzo-like conserved region HSP70 PF00012.20 EFC45601.1 - 4.2 5.4 13.1 30 2.6 0.0 2.0 1 1 1 2 2 2 0 Hsp70 protein CHASE6_C PF17150.4 EFC45601.1 - 4.5 8.0 7.9 28 5.5 2.9 2.7 1 1 1 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain Hrs_helical PF12210.8 EFC45601.1 - 5.5 7.6 11.7 9.3 6.9 3.2 2.3 1 1 1 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Phage_Mu_Gam PF07352.12 EFC45601.1 - 6.1 6.7 14.5 2e+02 1.8 14.4 2.4 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein Rho_Binding PF08912.11 EFC45601.1 - 7.8 7.4 20.5 5.1 8.0 9.6 2.5 1 1 2 3 3 3 0 Rho Binding TMPIT PF07851.13 EFC45601.1 - 8.2 5.6 13.0 4.3 6.5 7.3 1.8 1 1 1 2 2 2 0 TMPIT-like protein DUF641 PF04859.12 EFC45601.1 - 8.9 6.7 14.0 4.7 7.6 10.0 2.3 2 1 1 3 3 2 0 Plant protein of unknown function (DUF641) Bacteroid_pep PF14406.6 EFC45602.1 - 0.22 11.9 0.2 0.22 11.9 0.2 2.5 3 0 0 3 3 3 0 Ribosomally synthesized peptide in Bacteroidetes APG6_N PF17675.1 EFC45603.1 - 1.9 9.0 10.9 6.9 7.2 10.9 2.0 1 0 0 1 1 1 0 Apg6 coiled-coil region Phage_holin_3_6 PF07332.11 EFC45604.1 - 0.053 13.6 1.6 1.2 9.2 0.1 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4577 PF15145.6 EFC45604.1 - 0.11 12.6 0.4 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Epiglycanin_C PF14654.6 EFC45604.1 - 0.49 10.5 0.0 0.49 10.5 0.0 2.4 2 1 0 2 2 2 0 Mucin, catalytic, TM and cytoplasmic tail region SQAPI PF16845.5 EFC45605.1 - 0.00034 20.9 0.0 0.00046 20.5 0.0 1.2 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor Cystatin PF00031.21 EFC45605.1 - 0.0015 18.7 0.0 0.0018 18.5 0.0 1.3 1 0 0 1 1 1 1 Cystatin domain Phage_holin_3_6 PF07332.11 EFC45606.1 - 0.24 11.5 3.0 0.35 10.9 3.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF5345 PF17280.2 EFC45606.1 - 1.3 9.0 6.8 0.33 11.0 3.5 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5345) Voltage_CLC PF00654.20 EFC45607.1 - 1.4e-59 202.2 34.1 1.7e-59 201.9 29.6 2.2 1 1 1 2 2 2 2 Voltage gated chloride channel Creatinase_N_2 PF16189.5 EFC45609.1 - 3.4e-50 170.3 0.0 3.4e-49 167.0 0.1 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 EFC45609.1 - 3.2e-35 121.7 0.0 1.6e-34 119.4 0.0 1.9 2 0 0 2 2 2 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 EFC45609.1 - 2.9e-21 75.3 0.2 6.6e-21 74.2 0.2 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 EFC45609.1 - 3.7e-20 72.9 0.0 4.3e-14 53.3 0.0 2.3 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Plant_vir_prot PF01307.17 EFC45609.1 - 0.013 15.8 0.3 0.068 13.4 0.0 2.2 2 0 0 2 2 2 0 Plant viral movement protein Ion_trans PF00520.31 EFC45609.1 - 0.05 12.8 0.0 0.095 11.9 0.0 1.3 1 0 0 1 1 1 0 Ion transport protein RGS PF00615.19 EFC45610.1 - 3.5e-07 30.5 5.4 1.1e-06 28.9 5.4 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain Orf78 PF06024.12 EFC45610.1 - 0.003 17.8 6.7 0.86 9.9 0.3 3.5 3 0 0 3 3 3 2 Orf78 (ac78) Guanylin PF02058.15 EFC45610.1 - 0.088 13.3 0.2 0.25 11.9 0.2 1.7 1 0 0 1 1 1 0 Guanylin precursor Ninjurin PF04923.12 EFC45610.1 - 0.56 10.2 5.2 0.17 11.8 0.8 2.2 2 0 0 2 2 2 0 Ninjurin Baculo_11_kDa PF06143.11 EFC45610.1 - 4.2 7.0 8.5 3.8 7.2 2.4 2.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family Sigma_reg_N PF13800.6 EFC45610.1 - 4.8 7.5 7.2 3.3 8.1 0.9 2.8 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DmpG_comm PF07836.11 EFC45611.1 - 0.057 12.9 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 DmpG-like communication domain HTH_28 PF13518.6 EFC45611.1 - 0.098 12.8 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain TIG PF01833.24 EFC45611.1 - 0.4 10.8 3.3 1.5 8.9 0.0 3.3 3 1 0 3 3 3 0 IPT/TIG domain NHL PF01436.21 EFC45612.1 - 2.6e-83 270.1 11.7 6e-07 29.2 0.3 16.0 16 0 0 16 16 16 14 NHL repeat SGL PF08450.12 EFC45612.1 - 1e-13 51.4 8.5 0.0024 17.5 0.5 7.4 5 3 1 6 6 6 4 SMP-30/Gluconolactonase/LRE-like region Phytase-like PF13449.6 EFC45612.1 - 4.2e-08 33.5 4.3 0.62 10.0 0.0 8.9 6 4 3 10 10 10 1 Esterase-like activity of phytase FlgD_ig PF13860.6 EFC45612.1 - 0.0073 16.2 8.5 8.1 6.4 0.1 6.9 7 1 1 8 8 8 1 FlgD Ig-like domain YjcB PF15940.5 EFC45612.1 - 0.0098 16.1 0.6 25 5.1 0.0 4.3 4 0 0 4 4 4 2 Family of unknown function DUF5036 PF16439.5 EFC45612.1 - 4.3 7.0 8.3 3.3 7.4 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5036) PH PF00169.29 EFC45613.1 - 9.6e-11 42.1 4.3 1.8e-09 38.1 0.9 3.1 2 1 0 2 2 2 1 PH domain PH_9 PF15410.6 EFC45613.1 - 0.0019 18.5 0.9 0.069 13.5 0.4 3.5 2 1 0 2 2 2 1 Pleckstrin homology domain DUF4618 PF15397.6 EFC45613.1 - 0.0046 16.4 26.1 0.21 11.0 0.8 4.2 3 1 0 4 4 4 2 Domain of unknown function (DUF4618) RSS_P20 PF11757.8 EFC45613.1 - 0.012 16.0 6.9 0.012 16.0 6.9 3.8 5 0 0 5 5 5 0 Suppressor of RNA silencing P21-like N-terminal domain PH_11 PF15413.6 EFC45613.1 - 0.017 15.6 1.7 0.017 15.6 1.7 3.4 3 1 0 3 3 3 0 Pleckstrin homology domain SpecificRecomb PF10136.9 EFC45613.1 - 0.3 9.4 1.0 0.51 8.6 1.0 1.2 1 0 0 1 1 1 0 Site-specific recombinase Nup54 PF13874.6 EFC45613.1 - 1.9 8.6 18.5 0.4 10.8 6.0 2.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Macoilin PF09726.9 EFC45613.1 - 3.6 6.0 22.8 7.3 5.0 22.9 1.5 1 1 0 1 1 1 0 Macoilin family ZapB PF06005.12 EFC45613.1 - 5.5 7.5 43.5 0.58 10.6 5.3 4.6 2 1 2 4 4 4 0 Cell division protein ZapB Seadorna_VP6 PF07407.11 EFC45613.1 - 9.9 5.0 7.4 52 2.6 6.4 2.1 1 1 1 2 2 2 0 Seadornavirus VP6 protein ADH_zinc_N_2 PF13602.6 EFC45614.1 - 3.6e-10 41.0 0.0 5.9e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC45614.1 - 2e-09 37.3 0.0 3.9e-08 33.2 0.0 2.5 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC45614.1 - 2e-09 37.5 0.0 4.7e-09 36.3 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.8 EFC45614.1 - 0.0017 18.1 0.0 0.0034 17.1 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF2855 PF11017.8 EFC45614.1 - 0.0037 17.1 0.0 0.0053 16.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) ADH_N_2 PF16884.5 EFC45614.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Methyltransf_16 PF10294.9 EFC45614.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Ribosomal_L38e PF01781.18 EFC45615.1 - 2.5e-18 65.9 5.3 2.5e-18 65.9 5.3 1.9 2 0 0 2 2 2 1 Ribosomal L38e protein family Anthrax_toxA PF03497.16 EFC45615.1 - 0.012 15.7 1.3 0.027 14.6 1.3 1.5 1 0 0 1 1 1 0 Anthrax toxin LF subunit LisH_2 PF16045.5 EFC45615.1 - 0.37 9.9 1.6 7.2 5.7 0.4 2.3 2 0 0 2 2 2 0 LisH Med7 PF05983.11 EFC45616.1 - 1.9e-31 109.6 12.5 1.8e-29 103.2 12.5 2.7 1 1 0 1 1 1 1 MED7 protein DUF842 PF05811.13 EFC45616.1 - 0.053 13.2 0.2 0.098 12.4 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) pPIWI_RE_Y PF18156.1 EFC45616.1 - 0.1 13.0 0.0 0.25 11.8 0.0 1.7 2 0 0 2 2 2 0 pPIWI_RE three-gene island domain Y T3SS_basalb_I PF17001.5 EFC45616.1 - 0.12 13.0 0.5 0.3 11.7 0.2 1.8 1 1 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI Guanylate_cyc PF00211.20 EFC45617.1 - 0.0096 15.6 1.9 0.014 15.0 0.4 2.1 3 0 0 3 3 3 1 Adenylate and Guanylate cyclase catalytic domain SurA_N_2 PF13623.6 EFC45617.1 - 0.21 11.4 4.1 0.087 12.7 0.3 2.3 2 0 0 2 2 2 0 SurA N-terminal domain PIH1 PF08190.12 EFC45618.1 - 0.18 11.2 0.2 0.27 10.7 0.2 1.2 1 0 0 1 1 1 0 PIH1 N-terminal domain PPR_2 PF13041.6 EFC45619.1 - 5e-13 49.0 8.1 7.7e-13 48.4 0.0 4.0 5 0 0 5 5 5 1 PPR repeat family PPR PF01535.20 EFC45619.1 - 2.6e-09 36.7 6.8 0.0022 18.1 0.0 6.2 6 0 0 6 6 6 2 PPR repeat PPR_3 PF13812.6 EFC45619.1 - 6.6e-08 32.5 0.2 2.3e-06 27.6 0.0 2.9 2 1 0 2 2 2 1 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC45619.1 - 5.9e-07 29.1 1.6 1.9e-06 27.4 0.3 2.1 1 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP ANAPC3 PF12895.7 EFC45619.1 - 0.00038 20.6 2.2 0.12 12.6 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 ATP13 PF12921.7 EFC45619.1 - 0.0068 16.3 1.7 10 6.0 0.0 3.9 3 2 0 3 3 3 1 Mitochondrial ATPase expression PPR_1 PF12854.7 EFC45619.1 - 0.0085 15.8 9.4 0.055 13.2 0.0 4.3 5 0 0 5 5 5 1 PPR repeat FANCM-MHF_bd PF16783.5 EFC45619.1 - 0.014 15.4 0.2 0.03 14.4 0.2 1.5 1 0 0 1 1 1 0 FANCM to MHF binding domain DUF521 PF04412.13 EFC45619.1 - 0.081 11.6 1.3 0.43 9.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF521) Stap_Strp_toxin PF01123.20 EFC45619.1 - 5.8 7.8 10.0 18 6.2 0.1 3.4 2 1 1 3 3 3 0 Staphylococcal/Streptococcal toxin, OB-fold domain PPR_2 PF13041.6 EFC45620.1 - 5.7e-28 96.9 8.4 5.4e-12 45.7 0.1 4.3 2 2 2 4 4 4 4 PPR repeat family PPR PF01535.20 EFC45620.1 - 4.4e-24 83.0 3.5 4.4e-05 23.5 0.0 5.8 6 0 0 6 6 6 4 PPR repeat PPR_3 PF13812.6 EFC45620.1 - 5.4e-14 52.0 0.5 2.9e-05 24.0 0.0 4.2 1 1 3 4 4 4 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC45620.1 - 1.4e-13 50.3 7.8 0.00022 20.8 0.0 5.1 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 EFC45620.1 - 7.3e-07 28.8 0.0 0.0051 16.2 0.0 2.1 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP TPR_1 PF00515.28 EFC45620.1 - 1.9e-05 24.3 0.8 1.3 9.0 0.0 4.1 5 0 0 5 5 4 2 Tetratricopeptide repeat ATP13 PF12921.7 EFC45620.1 - 2.8e-05 24.0 0.7 12 5.8 0.0 4.5 1 1 4 5 5 5 0 Mitochondrial ATPase expression TPR_19 PF14559.6 EFC45620.1 - 0.00023 21.6 0.0 20 5.8 0.0 4.1 2 1 1 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC45620.1 - 0.00036 20.5 1.6 24 5.4 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45620.1 - 0.0013 18.9 0.0 0.14 12.4 0.0 2.7 2 2 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 MA3 PF02847.17 EFC45620.1 - 0.0018 18.3 0.1 0.17 11.9 0.1 2.2 2 0 0 2 2 2 1 MA3 domain FANCM-MHF_bd PF16783.5 EFC45620.1 - 0.0036 17.4 0.1 2.8 8.1 0.0 2.2 2 0 0 2 2 2 2 FANCM to MHF binding domain TPR_3 PF07720.12 EFC45620.1 - 0.0088 16.0 2.0 7 6.8 0.1 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat RPN7 PF10602.9 EFC45620.1 - 0.014 15.1 0.2 15 5.2 0.0 3.3 2 2 2 4 4 4 0 26S proteasome subunit RPN7 SNAP PF14938.6 EFC45620.1 - 0.026 13.9 0.0 0.71 9.2 0.0 2.2 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP ECSIT PF06239.11 EFC45620.1 - 0.037 13.1 0.2 0.62 9.1 0.1 2.7 1 1 3 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway Vps39_1 PF10366.9 EFC45620.1 - 0.046 14.0 0.0 7.3 6.9 0.0 3.0 1 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 Mistic PF11458.8 EFC45620.1 - 0.091 12.7 0.3 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Membrane-integrating protein Mistic TPR_7 PF13176.6 EFC45620.1 - 0.11 12.6 0.0 53 4.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3913 PF13052.6 EFC45620.1 - 0.14 12.5 0.0 28 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3913) DYW_deaminase PF14432.6 EFC45621.1 - 1.7e-28 99.0 0.1 4.6e-28 97.6 0.1 1.8 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases PPR PF01535.20 EFC45621.1 - 2.9e-21 74.2 0.3 3.2e-06 27.0 0.1 6.4 6 0 0 6 6 6 4 PPR repeat PPR_2 PF13041.6 EFC45621.1 - 1.3e-19 70.1 2.0 7.3e-13 48.5 0.1 5.6 4 1 2 6 6 6 3 PPR repeat family PPR_3 PF13812.6 EFC45621.1 - 9.3e-09 35.2 2.4 3.2e-05 23.9 0.1 4.5 2 2 3 5 5 5 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC45621.1 - 1.4e-08 34.3 2.3 0.0091 15.7 0.0 5.1 6 0 0 6 6 6 3 PPR repeat PPR_long PF17177.4 EFC45621.1 - 9.9e-07 28.3 0.0 3.1e-06 26.7 0.0 1.7 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP dCMP_cyt_deam_1 PF00383.23 EFC45621.1 - 0.0031 17.4 0.1 0.0065 16.3 0.1 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region TPR_14 PF13428.6 EFC45621.1 - 0.011 16.4 0.0 66 4.7 0.0 4.1 2 2 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45621.1 - 0.013 16.0 0.0 12 6.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Nmad4 PF18756.1 EFC45621.1 - 0.034 14.5 0.0 12 6.3 0.0 2.7 1 1 1 2 2 2 0 Nucleotide modification associated domain 4 TPR_8 PF13181.6 EFC45621.1 - 0.12 12.7 0.0 7.9 7.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1694 PF07997.11 EFC45625.1 - 0.0093 16.0 0.7 3.3 7.8 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1694) DUF5529 PF17669.1 EFC45625.1 - 0.035 14.1 0.2 2.9 7.9 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5529) DUF4116 PF13475.6 EFC45626.1 - 2e-18 65.8 35.9 9.7e-09 34.8 0.9 9.0 2 2 6 9 9 9 7 Domain of unknown function (DUF4116) NAD_binding_10 PF13460.6 EFC45627.1 - 1.1e-22 80.8 0.0 1.4e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC45627.1 - 9.4e-12 44.9 0.0 1.2e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFC45627.1 - 2.1e-09 37.3 0.0 7.5e-09 35.5 0.0 1.7 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 EFC45627.1 - 1.4e-05 24.3 0.6 1.9e-05 23.8 0.6 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC45627.1 - 9.8e-05 21.9 0.0 0.00018 21.0 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFC45627.1 - 0.00018 20.8 0.1 0.014 14.6 0.1 2.2 2 0 0 2 2 2 2 Male sterility protein Semialdhyde_dh PF01118.24 EFC45627.1 - 0.01 16.3 0.1 0.024 15.1 0.0 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFC45627.1 - 0.01 15.0 0.1 0.02 14.1 0.1 1.8 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein adh_short PF00106.25 EFC45627.1 - 0.021 14.3 0.1 0.044 13.2 0.1 1.6 1 1 0 1 1 1 0 short chain dehydrogenase RELT PF12606.8 EFC45627.1 - 0.036 13.0 2.2 0.07 12.1 2.2 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 TLD PF07534.16 EFC45628.1 - 1.5e-07 31.7 1.0 2.3e-07 31.1 0.2 1.7 2 0 0 2 2 2 1 TLD Dor1 PF04124.12 EFC45628.1 - 0.072 11.8 0.3 0.11 11.2 0.3 1.2 1 0 0 1 1 1 0 Dor1-like family Actin PF00022.19 EFC45629.1 - 5.8e-75 252.4 0.0 1.8e-74 250.8 0.0 1.6 1 1 0 1 1 1 1 Actin GATase_7 PF13537.6 EFC45629.1 - 0.074 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase domain zf-B_box PF00643.24 EFC45630.1 - 9.5e-08 32.1 3.4 9.5e-08 32.1 3.4 3.8 4 0 0 4 4 4 1 B-box zinc finger NHL PF01436.21 EFC45630.1 - 1.2e-05 25.0 4.1 0.0032 17.4 1.5 3.3 2 0 0 2 2 2 2 NHL repeat MRP-S28 PF10213.9 EFC45630.1 - 0.062 13.7 5.3 0.095 13.1 0.1 3.3 2 1 1 4 4 4 0 Mitochondrial ribosomal subunit protein THDPS_N PF14790.6 EFC45630.1 - 0.14 11.9 7.6 0.017 14.9 2.8 1.9 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal FYVE PF01363.21 EFC45630.1 - 6 7.1 19.1 2.1 8.5 3.5 3.4 2 2 1 3 3 3 0 FYVE zinc finger C1_2 PF03107.16 EFC45630.1 - 7.3 7.0 16.7 0.33 11.3 1.5 3.8 4 0 0 4 4 4 0 C1 domain Metallophos PF00149.28 EFC45631.1 - 9.1e-20 72.0 0.5 1.4e-19 71.4 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFC45631.1 - 1.3e-13 51.3 1.1 2e-13 50.7 0.1 1.8 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 EFC45631.1 - 0.0062 16.7 0.0 0.044 14.0 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain NHL PF01436.21 EFC45632.1 - 3.7e-35 118.2 14.1 7.9e-05 22.5 0.0 10.3 10 0 0 10 10 10 8 NHL repeat GPS PF01825.21 EFC45632.1 - 6.8e-05 23.3 0.5 0.00019 21.9 0.5 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC45632.1 - 0.038 14.4 11.8 0.076 13.4 7.3 2.7 2 0 0 2 2 2 0 EGF-like domain EGF_Tenascin PF18720.1 EFC45632.1 - 7.3 6.8 10.7 5 7.3 5.7 2.6 2 0 0 2 2 2 0 Tenascin EGF domain Pkinase PF00069.25 EFC45635.1 - 1.8e-31 109.5 0.1 2.3e-29 102.6 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45635.1 - 4.9e-29 101.4 0.0 5.6e-24 84.8 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45635.1 - 9.2e-05 21.4 0.1 0.0001 21.3 0.1 1.0 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC45635.1 - 0.00043 19.3 0.0 0.0005 19.1 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC45635.1 - 0.00075 19.5 0.0 0.00095 19.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC45635.1 - 0.0017 17.4 0.1 0.0022 17.1 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 EFC45635.1 - 0.0039 16.6 0.0 0.0047 16.3 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC45635.1 - 0.0055 16.1 0.0 0.006 15.9 0.0 1.1 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFC45635.1 - 0.064 12.9 0.0 0.08 12.5 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Virul_fac_BrkB PF03631.15 EFC45636.1 - 0.0062 16.2 4.5 0.0072 16.0 4.5 1.0 1 0 0 1 1 1 1 Virulence factor BrkB DUF4079 PF13301.6 EFC45636.1 - 0.0097 16.1 0.1 0.011 15.9 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4079) DUF2207 PF09972.9 EFC45636.1 - 0.074 11.8 2.5 0.085 11.6 2.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Rax2 PF12768.7 EFC45636.1 - 0.092 12.2 0.8 0.12 11.8 0.8 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Orai-1 PF07856.12 EFC45636.1 - 0.093 12.4 4.4 0.31 10.7 0.1 2.0 1 1 1 2 2 2 0 Mediator of CRAC channel activity Spore_YhaL PF14147.6 EFC45636.1 - 0.27 11.0 0.0 0.27 11.0 0.0 2.6 3 1 0 3 3 3 0 Sporulation protein YhaL DUF2892 PF11127.8 EFC45636.1 - 0.29 11.2 7.2 1.3 9.1 6.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2892) TssN PF17555.2 EFC45636.1 - 1.2 8.4 8.2 0.32 10.4 0.9 2.0 1 1 1 2 2 2 0 Type VI secretion system, TssN Ninjurin PF04923.12 EFC45636.1 - 1.4 8.9 7.7 6.9 6.7 0.4 2.6 1 1 1 2 2 2 0 Ninjurin DHHC PF01529.20 EFC45636.1 - 2.1 8.5 6.1 14 5.8 6.1 2.0 1 1 0 1 1 1 0 DHHC palmitoyltransferase Dpy-30 PF05186.13 EFC45637.1 - 0.0003 20.4 0.1 0.033 13.9 0.1 2.3 2 0 0 2 2 2 2 Dpy-30 motif LRR_6 PF13516.6 EFC45638.1 - 3.7e-50 163.7 24.9 8.5e-06 25.4 0.4 13.4 13 0 0 13 13 13 11 Leucine Rich repeat LRR_8 PF13855.6 EFC45638.1 - 3.4e-26 90.8 14.8 3.2e-06 26.8 1.0 6.0 3 1 2 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC45638.1 - 4.9e-22 77.6 22.8 0.005 17.2 2.4 8.8 1 1 9 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45638.1 - 7.7e-10 37.9 12.7 2.5 9.0 0.1 10.8 12 1 0 12 12 12 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC45638.1 - 3.6e-06 26.6 5.0 0.024 14.1 0.2 3.9 1 1 4 5 5 5 3 Leucine-rich repeat CLU_N PF15044.6 EFC45638.1 - 0.071 13.5 0.4 2.8 8.3 0.0 3.1 4 0 0 4 4 4 0 Mitochondrial function, CLU-N-term DUF1815 PF08844.10 EFC45638.1 - 0.16 11.9 0.2 76 3.4 0.0 4.5 4 2 0 4 4 4 0 Domain of unknown function (DUF1815) Glyco_hydro_38N PF01074.22 EFC45639.1 - 6.8e-82 275.1 2.2 6.8e-82 275.1 2.2 2.1 3 0 0 3 3 3 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 EFC45639.1 - 1.7e-20 73.0 2.0 1.7e-20 73.0 2.0 2.4 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 EFC45639.1 - 4.6e-16 59.6 0.0 4.6e-16 59.6 0.0 2.8 4 0 0 4 4 4 1 Glycosyl hydrolases family 38 C-terminal domain DotU PF09850.9 EFC45639.1 - 0.11 12.2 0.0 0.5 10.0 0.0 2.0 2 0 0 2 2 2 0 Type VI secretion system protein DotU CID_GANP PF16766.5 EFC45639.1 - 0.21 11.8 1.3 0.55 10.5 1.3 1.6 1 0 0 1 1 1 0 Binding region of GANP to ENY2 LPAM_1 PF08139.12 EFC45640.1 - 0.12 12.9 1.8 0.19 12.3 1.8 1.3 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site DUF4116 PF13475.6 EFC45641.1 - 6e-54 179.6 31.5 8.2e-12 44.7 0.0 10.4 7 2 2 10 10 10 9 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC45641.1 - 7.9e-25 87.7 0.3 7.9e-25 87.7 0.3 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45641.1 - 1.2e-19 70.6 0.0 2.5e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Antimicrobial_8 PF08103.11 EFC45641.1 - 0.17 12.1 0.1 0.82 9.9 0.1 2.2 1 0 0 1 1 1 0 Uperin family DUF1447 PF07288.11 EFC45641.1 - 2.3 8.3 5.1 1.6 8.8 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1447) MHC_I_3 PF16497.5 EFC45642.1 - 0.05 13.1 0.1 0.12 11.8 0.1 1.6 2 0 0 2 2 2 0 MHC-I family domain DNA_pol_A_exo1 PF01612.20 EFC45645.1 - 3.1e-12 46.5 0.2 6.7e-08 32.4 0.0 2.4 2 0 0 2 2 2 2 3'-5' exonuclease DUF445 PF04286.12 EFC45645.1 - 0.029 14.2 0.1 0.029 14.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF445) TIP120 PF08623.10 EFC45645.1 - 0.038 13.8 0.0 0.28 10.9 0.0 2.3 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) KH_1 PF00013.29 EFC45645.1 - 0.038 13.8 0.1 22 5.0 0.0 3.3 3 0 0 3 3 3 0 KH domain CCDC50_N PF15295.6 EFC45645.1 - 0.093 12.9 0.1 0.26 11.4 0.1 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus MbeB_N PF04837.12 EFC45646.1 - 0.0026 18.0 3.8 0.0026 18.0 3.8 3.5 3 1 1 4 4 3 1 MbeB-like, N-term conserved region Mitofilin PF09731.9 EFC45646.1 - 0.0053 15.7 17.1 0.0063 15.4 17.1 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Phasin PF05597.11 EFC45646.1 - 0.0079 16.2 16.8 0.046 13.7 7.8 2.8 1 1 2 3 3 3 2 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF1572 PF07609.11 EFC45646.1 - 0.013 15.2 1.8 0.013 15.2 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1572) DUF883 PF05957.13 EFC45646.1 - 0.018 15.6 9.0 0.98 10.1 0.6 3.6 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 EFC45646.1 - 0.02 14.8 9.5 0.094 12.6 9.5 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain RapA_C PF12137.8 EFC45646.1 - 0.039 13.0 17.2 0.059 12.4 6.5 2.1 1 1 1 2 2 2 0 RNA polymerase recycling family C-terminal CCP_MauG PF03150.14 EFC45646.1 - 0.12 13.0 2.2 0.16 12.7 2.2 1.2 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase YtxH PF12732.7 EFC45646.1 - 0.24 11.9 20.0 2.5 8.7 7.1 3.8 1 1 1 2 2 2 0 YtxH-like protein FdhE PF04216.12 EFC45646.1 - 0.28 11.0 3.3 0.33 10.8 3.3 1.2 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation DUF1179 PF06678.11 EFC45646.1 - 0.33 11.0 5.8 0.3 11.1 1.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1179) DUF45 PF01863.17 EFC45646.1 - 0.36 10.9 9.5 0.48 10.4 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF45 DUF4145 PF13643.6 EFC45646.1 - 0.54 10.4 9.1 0.099 12.8 1.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4145) DUF445 PF04286.12 EFC45646.1 - 0.56 9.9 17.4 1.6 8.5 16.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Synuclein PF01387.17 EFC45646.1 - 0.74 10.0 10.3 0.15 12.3 0.6 2.4 1 1 1 2 2 2 0 Synuclein CFAP91 PF14738.6 EFC45646.1 - 0.75 9.8 12.5 1.4 9.0 12.5 1.5 1 0 0 1 1 1 0 Cilia- and flagella-associated protein 91 Atypical_Card PF18461.1 EFC45646.1 - 0.87 9.8 4.3 2 8.7 0.1 2.6 1 1 2 3 3 3 0 Atypical caspase recruitment domain ARGLU PF15346.6 EFC45646.1 - 0.94 9.4 17.3 4.6 7.1 14.2 2.4 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 TCTP PF00838.17 EFC45646.1 - 1.7 8.9 18.9 0.9 9.9 15.6 2.0 1 1 1 2 2 2 0 Translationally controlled tumour protein ApoO PF09769.9 EFC45646.1 - 1.8 8.5 10.9 18 5.3 0.2 3.0 1 1 1 2 2 2 0 Apolipoprotein O ZYG-11_interact PF05884.12 EFC45646.1 - 2 7.7 13.2 0.94 8.8 9.2 2.0 1 1 1 2 2 2 0 Interactor of ZYG-11 zf-CRD PF17979.1 EFC45646.1 - 2.1 8.4 9.1 3.8 7.6 8.4 1.9 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions ICE2 PF08426.10 EFC45646.1 - 2.3 7.2 7.2 1.5 7.8 5.0 1.8 1 1 0 1 1 1 0 ICE2 DUF2937 PF11157.8 EFC45646.1 - 4.3 7.0 7.6 5.8 6.6 0.8 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2937) Helicase_IV_N PF12462.8 EFC45646.1 - 4.4 7.2 11.6 4.8 7.1 1.1 2.6 1 1 2 3 3 3 0 DNA helicase IV / RNA helicase N terminal DFF40 PF09230.10 EFC45646.1 - 4.8 6.7 14.3 0.99 9.0 7.4 2.0 2 0 0 2 2 2 0 DNA fragmentation factor 40 kDa Tctex-1 PF03645.13 EFC45646.1 - 6.4 7.1 15.0 0.71 10.1 1.1 2.8 2 1 0 2 2 2 0 Tctex-1 family STAT_int PF02865.17 EFC45646.1 - 7.1 7.1 11.9 4.4 7.8 4.3 2.4 1 1 1 2 2 2 0 STAT protein, protein interaction domain dCache_2 PF08269.11 EFC45646.1 - 9.6 5.3 25.0 5.1 6.2 10.7 2.2 1 1 1 2 2 2 0 Cache domain ubiquitin PF00240.23 EFC45648.1 - 2.8e-63 209.6 6.5 2.4e-31 107.3 0.8 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC45648.1 - 3.9e-30 103.5 8.2 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC45648.1 - 2.6e-09 37.4 3.7 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC45648.1 - 7.9e-09 35.3 0.3 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC45648.1 - 9.9e-09 35.3 0.4 0.001 19.2 0.0 2.9 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC45648.1 - 4.6e-07 30.1 2.1 0.015 15.7 0.3 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC45648.1 - 5.6e-07 30.1 0.1 0.014 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC45648.1 - 0.00015 21.8 6.7 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain TUG-UBL1 PF11470.8 EFC45648.1 - 0.0029 17.8 0.0 0.33 11.2 0.0 2.1 2 0 0 2 2 2 1 TUG ubiquitin-like domain Coagulin PF02035.15 EFC45648.1 - 0.016 15.1 0.3 1.2 9.0 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC45648.1 - 0.034 14.3 0.7 0.53 10.5 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) Raf1_HTH PF18579.1 EFC45648.1 - 0.037 13.7 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain bPH_3 PF14470.6 EFC45648.1 - 0.076 13.4 1.2 0.74 10.2 0.4 2.5 2 1 1 3 3 3 0 Bacterial PH domain ProRS-C_2 PF09181.10 EFC45648.1 - 0.087 13.0 1.5 11 6.3 0.3 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_p85B PF02192.16 EFC45648.1 - 0.11 12.2 0.6 14 5.5 0.1 2.3 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.18 EFC45648.1 - 0.15 12.2 1.9 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain PAXIP1_C PF15364.6 EFC45649.1 - 0.015 15.6 2.2 0.015 15.6 2.2 1.6 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein TcdA_TcdB_pore PF12920.7 EFC45649.1 - 0.082 11.1 1.1 0.099 10.9 1.1 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain SR-25 PF10500.9 EFC45649.1 - 0.65 9.6 13.0 1.5 8.4 13.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM70 PF14967.6 EFC45649.1 - 4.7 6.6 7.3 1.7 8.1 5.0 1.4 1 1 0 1 1 1 0 FAM70 protein F-box PF00646.33 EFC45650.1 - 0.0055 16.6 0.0 0.019 14.9 0.0 1.9 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 EFC45650.1 - 0.028 14.9 18.8 3.8 8.1 0.1 7.8 4 3 5 9 9 9 0 Leucine Rich repeats (2 copies) Flavodoxin_2 PF02525.17 EFC45651.1 - 1.7e-38 132.4 0.0 2e-38 132.1 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 EFC45651.1 - 3.2e-05 23.7 0.0 4.6e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase FBA_2 PF07735.17 EFC45651.1 - 0.73 10.0 6.4 24 5.2 1.7 3.8 2 2 1 3 3 3 0 F-box associated DUF410 PF04190.13 EFC45654.1 - 0.045 13.6 1.9 0.061 13.1 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF410) Homoserine_dh PF00742.19 EFC45654.1 - 0.085 12.8 0.6 0.21 11.5 0.6 1.7 1 1 0 1 1 1 0 Homoserine dehydrogenase DUF3316 PF11777.8 EFC45654.1 - 0.13 12.4 0.8 0.2 11.7 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3316) Pkinase PF00069.25 EFC45655.1 - 8.7e-33 113.8 0.1 1.9e-32 112.7 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45655.1 - 1.5e-16 60.5 0.1 2.7e-16 59.6 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45655.1 - 1.2e-05 24.2 0.3 5.4e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC45655.1 - 0.00028 20.0 0.3 0.00028 20.0 0.3 2.1 2 1 1 3 3 3 1 Haspin like kinase domain APH PF01636.23 EFC45655.1 - 0.0012 18.9 0.0 0.0019 18.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family PPP5 PF08321.12 EFC45655.1 - 0.064 13.6 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 PPP5 TPR repeat region XRN1_D2_D3 PF18334.1 EFC45655.1 - 0.093 13.0 2.3 0.13 12.4 0.0 2.3 3 0 0 3 3 3 0 Exoribonuclease Xrn1 D2/D3 domain ABC1 PF03109.16 EFC45655.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 ABC1 family DUF4116 PF13475.6 EFC45658.1 - 2.1e-80 264.2 21.7 1.1e-13 50.6 0.0 12.1 7 2 2 12 12 12 11 Domain of unknown function (DUF4116) NitrOD5 PF11537.8 EFC45658.1 - 0.0071 16.5 0.2 0.73 10.0 0.0 2.6 2 0 0 2 2 2 2 Nitrosopumilus output domain 5 Peptidase_M14 PF00246.24 EFC45660.1 - 1.6e-71 241.4 1.6 2.2e-71 241.0 1.6 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 EFC45660.1 - 2.9e-12 46.7 0.3 6.8e-12 45.5 0.3 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFC45660.1 - 1.7e-07 31.2 0.4 4.1e-07 29.9 0.4 1.6 1 0 0 1 1 1 1 CarboxypepD_reg-like domain AstE_AspA PF04952.14 EFC45660.1 - 5.7e-07 28.9 0.1 1.3e-06 27.8 0.1 1.5 1 1 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2817 PF10994.8 EFC45660.1 - 0.00042 19.8 0.1 0.00065 19.2 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) Big_1 PF02369.16 EFC45660.1 - 0.016 15.2 3.8 0.041 13.9 0.6 2.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) Gmad2 PF10648.9 EFC45660.1 - 0.038 14.2 0.0 0.51 10.6 0.0 2.7 2 0 0 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination HIP1_clath_bdg PF16515.5 EFC45660.1 - 0.12 13.0 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 zf-rbx1 PF12678.7 EFC45661.1 - 1.1e-24 86.4 16.8 1.5e-24 86.0 16.8 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 EFC45661.1 - 4.2e-16 58.8 14.0 5.2e-16 58.5 14.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 EFC45661.1 - 1.6e-07 31.5 19.0 9.8e-06 25.8 19.0 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC45661.1 - 3.3e-05 23.6 8.0 3.3e-05 23.6 8.0 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC45661.1 - 0.00041 20.2 16.8 0.013 15.4 16.8 2.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFC45661.1 - 0.09 13.0 3.3 0.09 13.0 3.3 2.8 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EFC45661.1 - 0.11 12.2 15.2 7.8 6.3 15.2 2.7 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 EFC45661.1 - 0.22 11.4 18.6 0.95 9.4 12.2 2.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_16 PF17034.5 EFC45661.1 - 0.8 9.9 13.9 0.39 11.0 10.6 1.8 1 1 1 2 2 2 0 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 EFC45661.1 - 1.2 8.8 22.2 0.39 10.4 11.5 2.2 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EFC45661.1 - 3.9 7.6 12.9 3.7 7.7 10.3 2.4 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 EFC45661.1 - 9.4 6.3 21.0 3.3e+02 1.3 21.0 2.8 1 1 1 2 2 2 0 zinc-RING finger domain Med9 PF07544.13 EFC45662.1 - 3.3e-05 23.9 0.7 5.9e-05 23.1 0.7 1.4 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 TFA2_Winged_2 PF18121.1 EFC45662.1 - 0.028 14.1 0.0 0.056 13.1 0.0 1.5 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 SAPS PF04499.15 EFC45663.1 - 1.5e-46 159.3 32.1 1.3e-27 96.8 2.4 5.2 3 1 2 5 5 5 3 SIT4 phosphatase-associated protein U3snoRNP10 PF12397.8 EFC45663.1 - 0.59 10.5 6.2 0.34 11.3 0.8 2.8 2 1 0 2 2 2 0 U3 small nucleolar RNA-associated protein 10 DUF31 PF01732.16 EFC45663.1 - 4.5 6.7 8.0 1.7 8.1 0.5 2.2 2 0 0 2 2 2 0 Putative peptidase (DUF31) bZIP_1 PF00170.21 EFC45665.1 - 6.7e-09 35.7 15.6 6.7e-09 35.7 15.6 2.5 2 1 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 EFC45665.1 - 5.7e-08 32.7 19.4 5.7e-08 32.7 19.4 2.1 3 0 0 3 3 3 1 Basic region leucine zipper TSC22 PF01166.18 EFC45665.1 - 0.013 15.8 2.6 0.013 15.8 2.6 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family bZIP_Maf PF03131.17 EFC45665.1 - 0.071 13.6 18.5 0.065 13.8 16.5 2.1 1 1 1 2 2 2 0 bZIP Maf transcription factor Rhomboid PF01694.22 EFC45666.1 - 7.6e-24 84.4 12.8 7.6e-24 84.4 12.8 1.7 2 0 0 2 2 2 1 Rhomboid family Phage_holin_2_3 PF16080.5 EFC45666.1 - 0.014 15.1 0.6 0.045 13.5 0.0 2.0 2 0 0 2 2 2 0 Bacteriophage holin family HP1 DUF997 PF06196.12 EFC45666.1 - 0.41 10.7 0.1 0.41 10.7 0.1 3.5 5 0 0 5 5 5 0 Protein of unknown function (DUF997) LRR_6 PF13516.6 EFC45667.1 - 1.1e-27 93.7 0.0 0.00011 22.0 0.0 6.2 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC45667.1 - 6.9e-20 70.6 6.0 3.9e-08 32.9 0.2 3.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC45667.1 - 1.3e-17 63.6 18.0 0.00085 19.7 0.2 4.2 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45667.1 - 9e-11 40.8 0.0 13 6.8 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC45667.1 - 1.8e-05 24.3 0.2 0.035 13.6 0.1 2.1 1 1 1 2 2 2 2 Leucine-rich repeat Apo-VLDL-II PF05418.11 EFC45667.1 - 0.0012 19.4 0.1 15 6.2 0.0 3.3 1 1 2 3 3 3 0 Apovitellenin I (Apo-VLDL-II) Beta_helix PF13229.6 EFC45667.1 - 0.0024 17.8 2.8 0.0041 17.0 2.8 1.4 1 0 0 1 1 1 1 Right handed beta helix region Arteri_GP4 PF02497.15 EFC45667.1 - 0.0029 17.8 0.6 17 5.5 0.0 3.0 1 1 1 3 3 3 0 Arterivirus glycoprotein Glyco_tranf_2_4 PF13704.6 EFC45667.1 - 0.0044 17.5 0.0 6.3 7.4 0.0 3.0 1 1 2 3 3 3 1 Glycosyl transferase family 2 BCDHK_Adom3 PF10436.9 EFC45667.1 - 0.015 15.1 0.2 0.5 10.2 0.0 2.0 1 1 1 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF4361 PF14274.6 EFC45667.1 - 0.029 14.7 6.1 0.88 9.8 2.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4361) Peptidase_C39_2 PF13529.6 EFC45667.1 - 0.033 14.7 1.6 11 6.6 0.0 2.8 1 1 2 3 3 3 0 Peptidase_C39 like family Astro_capsid_p2 PF16580.5 EFC45667.1 - 0.086 12.3 0.7 5.2 6.4 0.1 2.5 1 1 2 3 3 3 0 C-terminal tail of astrovirus capsid projection or spike HydF_dimer PF18128.1 EFC45667.1 - 0.09 12.9 0.0 5 7.3 0.0 2.6 1 1 2 3 3 3 0 Hydrogen maturase F dimerization domain UPF0193 PF05250.11 EFC45667.1 - 0.091 12.5 7.8 1.5 8.6 0.1 2.9 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0193) EXS PF03124.14 EFC45668.1 - 4.9e-56 190.4 16.9 6.2e-56 190.1 16.9 1.1 1 0 0 1 1 1 1 EXS family XTBD PF11952.8 EFC45668.1 - 0.0017 18.0 0.1 0.014 15.2 0.0 2.2 2 0 0 2 2 2 1 XRN-Two Binding Domain, XTBD SPX PF03105.19 EFC45669.1 - 1.9e-05 24.8 41.8 0.00013 22.0 1.7 4.3 1 1 3 4 4 4 3 SPX domain SR-25 PF10500.9 EFC45669.1 - 0.055 13.1 4.5 0.1 12.2 4.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ASC PF00858.24 EFC45670.1 - 5.5e-07 28.9 22.3 0.0013 17.8 0.2 3.9 1 1 3 4 4 4 3 Amiloride-sensitive sodium channel zf-U1 PF06220.12 EFC45670.1 - 0.28 11.0 3.3 0.64 9.8 3.3 1.5 1 0 0 1 1 1 0 U1 zinc finger CMV_1a PF12467.8 EFC45671.1 - 0.58 10.5 8.0 6.5 7.1 0.4 2.3 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family Helicase_C_2 PF13307.6 EFC45672.1 - 1.1e-53 182.0 2.5 2.9e-53 180.5 0.0 3.0 4 0 0 4 4 4 1 Helicase C-terminal domain DEAD_2 PF06733.15 EFC45672.1 - 3.6e-42 144.0 7.8 3.6e-42 144.0 7.8 2.2 2 0 0 2 2 2 1 DEAD_2 DEAD PF00270.29 EFC45672.1 - 2.5e-05 24.1 0.0 0.0038 17.0 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase PhoH PF02562.16 EFC45672.1 - 0.0027 17.2 0.1 1.1 8.7 0.0 2.9 3 0 0 3 3 3 2 PhoH-like protein ResIII PF04851.15 EFC45672.1 - 0.055 13.5 11.4 1.9 8.5 0.1 4.3 3 2 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFC45672.1 - 0.93 9.8 2.9 3.5 7.9 0.0 3.0 2 1 0 2 2 2 0 AAA domain UPF0240 PF06784.11 EFC45673.1 - 0.087 12.9 5.5 0.21 11.6 5.5 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) DUF3575 PF12099.8 EFC45673.1 - 0.17 11.1 0.1 0.26 10.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3575) FRB_dom PF08771.11 EFC45673.1 - 2.2 8.8 6.4 1.8 9.0 0.6 3.0 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain Pkinase PF00069.25 EFC45674.1 - 1.2e-25 90.4 0.9 5.5e-25 88.2 0.9 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45674.1 - 2.4e-10 40.2 0.1 6.8e-10 38.7 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC45674.1 - 7.8e-05 22.1 0.0 0.00012 21.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Hydrolase_4 PF12146.8 EFC45676.1 - 4.1e-16 59.0 0.0 8.3e-15 54.7 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC45676.1 - 1.1e-13 51.4 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 EFC45676.1 - 5.2e-05 23.2 0.1 0.86 9.4 0.0 3.0 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase DUF915 PF06028.11 EFC45676.1 - 0.00015 21.2 0.1 0.004 16.5 0.1 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) Ndr PF03096.14 EFC45676.1 - 0.00064 18.5 0.0 0.00074 18.3 0.0 1.1 1 0 0 1 1 1 1 Ndr family DUF2974 PF11187.8 EFC45676.1 - 0.00076 19.1 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) PAF-AH_p_II PF03403.13 EFC45676.1 - 0.00088 17.9 0.0 0.1 11.1 0.0 2.5 3 0 0 3 3 3 1 Platelet-activating factor acetylhydrolase, isoform II BAAT_C PF08840.11 EFC45676.1 - 0.0012 18.8 0.0 0.0015 18.5 0.0 1.1 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 EFC45676.1 - 0.0022 18.6 0.0 0.0024 18.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.10 EFC45676.1 - 0.0026 16.9 0.0 0.0039 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Esterase PF00756.20 EFC45676.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.6 1 1 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.21 EFC45676.1 - 0.025 14.1 0.0 0.069 12.6 0.0 1.7 1 1 0 1 1 1 0 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 EFC45676.1 - 0.026 13.4 0.4 0.028 13.3 0.4 1.4 1 1 0 1 1 1 0 Steryl acetyl hydrolase DLH PF01738.18 EFC45676.1 - 0.18 11.3 0.0 15 5.0 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family PAS PF00989.25 EFC45677.1 - 1.3e-08 34.8 0.0 4.7e-08 33.0 0.0 2.0 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EFC45677.1 - 2.9e-07 30.7 0.1 1.4e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 PAS domain RGS PF00615.19 EFC45677.1 - 2.3e-05 24.6 12.0 0.0035 17.6 3.1 3.3 3 0 0 3 3 3 2 Regulator of G protein signaling domain PAS_8 PF13188.7 EFC45677.1 - 0.00026 21.0 0.0 0.0006 19.8 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC45677.1 - 0.0065 16.7 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 PAS fold CCDC24 PF15669.5 EFC45677.1 - 0.021 14.7 0.1 0.021 14.7 0.1 3.1 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 24 family GIT_CC PF16559.5 EFC45677.1 - 0.076 12.9 1.6 0.35 10.8 1.5 2.2 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor SlyX PF04102.12 EFC45677.1 - 0.093 13.4 1.0 0.32 11.7 0.4 2.3 3 0 0 3 3 3 0 SlyX PH PF00169.29 EFC45677.1 - 0.3 11.6 6.3 0.17 12.4 0.7 3.2 2 1 0 2 2 2 0 PH domain CRA_rpt PF07046.11 EFC45678.1 - 0.093 12.9 1.4 0.28 11.4 1.4 1.8 1 0 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat Ribosomal_L19e PF01280.20 EFC45680.1 - 2.3e-57 193.1 8.4 2.3e-57 193.1 8.4 2.0 1 1 1 2 2 2 1 Ribosomal protein L19e Peptidase_M22 PF00814.25 EFC45681.1 - 2.6e-68 230.7 0.2 2e-66 224.5 0.2 2.2 1 1 0 1 1 1 1 Glycoprotease family YycC PF14174.6 EFC45681.1 - 0.0073 16.1 0.3 0.019 14.8 0.3 1.7 1 0 0 1 1 1 1 YycC-like protein NMD3 PF04981.13 EFC45682.1 - 1e-75 254.4 6.7 2.3e-75 253.2 6.7 1.6 1 0 0 1 1 1 1 NMD3 family Med28 PF11594.8 EFC45682.1 - 0.025 14.7 1.1 0.025 14.7 1.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 28 F-box-like PF12937.7 EFC45683.1 - 0.0049 16.7 0.3 0.013 15.3 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC45683.1 - 0.085 12.8 0.7 0.56 10.2 0.2 2.6 2 0 0 2 2 2 0 F-box domain Tiam_CC_Ex PF18385.1 EFC45684.1 - 0.13 12.6 0.2 0.59 10.5 0.0 2.2 2 0 0 2 2 2 0 T-lymphoma invasion and metastasis CC-Ex domain Pkinase PF00069.25 EFC45685.1 - 1.1e-49 169.1 1.3 1.7e-49 168.5 1.3 1.3 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC45685.1 - 2e-34 115.9 0.2 3.8e-05 23.5 0.0 10.3 10 0 0 10 10 10 6 NHL repeat Pkinase_Tyr PF07714.17 EFC45685.1 - 8.8e-30 103.8 0.2 1.3e-29 103.3 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase SGL PF08450.12 EFC45685.1 - 2.6e-07 30.5 1.8 0.0066 16.1 0.1 5.1 3 2 2 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 EFC45685.1 - 0.00017 21.6 1.4 2.3 8.4 0.0 5.8 5 2 1 6 6 6 1 Strictosidine synthase Arylesterase PF01731.20 EFC45685.1 - 0.00021 21.4 7.5 3.1 8.0 0.0 6.4 6 1 1 7 7 7 2 Arylesterase Pkinase_fungal PF17667.1 EFC45685.1 - 0.0016 17.3 0.1 0.0027 16.6 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase tRNA_anti-codon PF01336.25 EFC45685.1 - 0.012 15.6 0.4 22 5.1 0.0 4.8 4 1 1 5 5 5 0 OB-fold nucleic acid binding domain Phytase-like PF13449.6 EFC45685.1 - 0.046 13.7 0.1 0.59 10.0 0.0 2.8 3 1 0 3 3 3 0 Esterase-like activity of phytase Kdo PF06293.14 EFC45685.1 - 0.052 12.9 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4408 PF14364.6 EFC45685.1 - 1.5 8.6 9.2 15 5.4 0.1 4.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4408) ABC_membrane PF00664.23 EFC45687.1 - 2.7e-53 181.4 15.1 3.7e-53 181.0 15.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC45687.1 - 1.6e-36 125.8 0.0 3.5e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC45687.1 - 4.6e-08 32.8 0.2 3.4e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC45687.1 - 7.1e-05 23.3 0.0 0.00017 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC45687.1 - 0.00046 20.5 0.0 0.0018 18.6 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 EFC45687.1 - 0.00048 19.8 0.2 0.0012 18.5 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 EFC45687.1 - 0.0017 18.1 0.0 0.003 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain ABC_ATPase PF09818.9 EFC45687.1 - 0.0034 16.2 0.1 0.0073 15.2 0.0 1.6 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_30 PF13604.6 EFC45687.1 - 0.01 15.6 0.0 0.032 13.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFC45687.1 - 0.018 15.0 0.0 0.05 13.5 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EFC45687.1 - 0.02 15.4 0.0 0.051 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 EFC45687.1 - 0.022 14.6 0.0 0.17 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_5 PF07728.14 EFC45687.1 - 0.035 14.1 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 EFC45687.1 - 0.049 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFC45687.1 - 0.054 12.8 0.0 0.21 10.8 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 EFC45687.1 - 0.061 13.7 0.1 17 5.9 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 EFC45687.1 - 0.13 12.5 0.4 1.3 9.3 0.4 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF563 PF04577.14 EFC45688.1 - 1.6e-07 31.7 1.0 5.1e-07 30.0 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF563) Macoilin PF09726.9 EFC45689.1 - 0.00023 19.9 11.1 0.00029 19.6 11.1 1.2 1 0 0 1 1 1 1 Macoilin family OmpH PF03938.14 EFC45689.1 - 0.00024 21.4 9.8 0.00024 21.4 9.8 2.3 3 0 0 3 3 2 1 Outer membrane protein (OmpH-like) FPP PF05911.11 EFC45689.1 - 0.00035 18.9 15.6 0.00059 18.2 15.6 1.4 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Atg14 PF10186.9 EFC45689.1 - 0.13 11.3 12.2 0.26 10.3 12.2 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FDX-ACB PF03147.14 EFC45689.1 - 0.3 11.5 10.2 1.9 8.9 1.6 3.1 2 1 1 3 3 3 0 Ferredoxin-fold anticodon binding domain DUF641 PF04859.12 EFC45689.1 - 0.3 11.4 11.4 0.1 13.0 7.2 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Prismane PF03063.20 EFC45689.1 - 0.33 9.6 5.8 1.2 7.8 5.3 2.2 1 1 1 2 2 2 0 Prismane/CO dehydrogenase family LMBR1 PF04791.16 EFC45689.1 - 0.81 8.5 8.6 1.7 7.4 7.6 2.0 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF3450 PF11932.8 EFC45689.1 - 1 8.6 14.4 4 6.7 14.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Phage_GPO PF05929.11 EFC45689.1 - 1.4 8.4 8.5 1.3 8.6 6.7 1.8 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Mod_r PF07200.13 EFC45689.1 - 2.3 8.3 20.4 0.062 13.4 11.7 2.7 3 1 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein APG6_N PF17675.1 EFC45689.1 - 3.3 8.2 21.7 17 5.9 21.5 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region HSP70 PF00012.20 EFC45690.1 - 1.8e-05 23.1 0.6 3.1e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EFC45690.1 - 0.034 12.9 0.0 0.058 12.2 0.0 1.5 1 1 0 1 1 1 0 MreB/Mbl protein Form_Nir_trans PF01226.17 EFC45691.1 - 8.2e-68 228.3 23.8 1.2e-67 227.7 23.8 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter Lipase_GDSL_2 PF13472.6 EFC45692.1 - 7.3e-11 42.8 0.0 1.1e-10 42.3 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 EFC45692.1 - 5.2e-08 33.1 0.0 1.3e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CE2_N PF17996.1 EFC45692.1 - 0.0036 17.3 0.0 0.016 15.2 0.0 2.2 3 0 0 3 3 3 1 Carbohydrate esterase 2 N-terminal YebO PF13974.6 EFC45693.1 - 0.55 10.3 4.2 2.2 8.4 4.2 2.0 1 0 0 1 1 1 0 YebO-like protein Tubulin PF00091.25 EFC45694.1 - 3.5e-52 177.5 0.1 6.5e-52 176.6 0.1 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain VPS9 PF02204.18 EFC45695.1 - 1.2e-18 67.2 0.4 2.8e-18 66.0 0.4 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain E1-E2_ATPase PF00122.20 EFC45696.1 - 0.029 13.9 0.0 0.029 13.9 0.0 3.3 4 0 0 4 4 4 0 E1-E2 ATPase BTB PF00651.31 EFC45697.1 - 1e-09 38.6 2.2 1.2e-06 28.8 0.6 4.1 3 2 1 4 4 4 1 BTB/POZ domain DUF3342 PF11822.8 EFC45697.1 - 4.1e-06 26.9 2.0 6.6e-05 23.0 0.3 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3342) Ank_5 PF13857.6 EFC45697.1 - 0.0063 16.8 0.0 0.021 15.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC45697.1 - 0.0088 16.6 0.2 0.073 13.7 0.0 2.7 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) PDU_like PF15953.5 EFC45697.1 - 0.034 14.2 0.1 14 5.7 0.0 2.8 2 0 0 2 2 2 0 Putative propanediol utilisation Ank_3 PF13606.6 EFC45697.1 - 0.084 13.5 1.8 0.54 11.0 0.1 3.3 4 0 0 4 4 4 0 Ankyrin repeat Ank_4 PF13637.6 EFC45697.1 - 0.085 13.5 0.0 0.27 11.9 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) LRR_6 PF13516.6 EFC45698.1 - 3.5e-18 64.1 43.5 0.0019 18.1 0.0 12.9 13 1 0 13 13 13 8 Leucine Rich repeat LRR_4 PF12799.7 EFC45698.1 - 1.8e-11 44.0 60.4 0.0014 19.0 0.1 10.6 8 3 3 11 11 11 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45698.1 - 1.2e-05 24.9 52.0 2.7e-05 23.9 4.7 8.8 7 3 1 8 8 8 4 Leucine rich repeat LRR_9 PF14580.6 EFC45698.1 - 0.013 15.0 1.1 0.38 10.2 0.3 3.2 2 1 1 3 3 3 0 Leucine-rich repeat RPN6_N PF18055.1 EFC45698.1 - 0.2 12.0 0.1 0.97 9.8 0.1 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain LRR_1 PF00560.33 EFC45698.1 - 9.8 7.2 44.2 16 6.6 0.1 11.6 9 3 2 11 11 11 0 Leucine Rich Repeat MJ1316 PF04457.12 EFC45699.1 - 3.8e-08 33.9 0.0 1e-07 32.6 0.0 1.7 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain SprA-related PF12118.8 EFC45699.1 - 0.12 11.5 2.4 0.2 10.7 2.4 1.3 1 0 0 1 1 1 0 SprA-related family COX16 PF14138.6 EFC45699.1 - 1.4 9.5 7.1 21 5.7 0.1 2.5 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 UCH PF00443.29 EFC45700.1 - 2e-17 63.5 4.9 2e-17 63.5 4.9 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4854 PF16146.5 EFC45700.1 - 0.54 10.6 6.1 1.5 9.2 3.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4854) Varsurf_PPLC PF03490.13 EFC45701.1 - 0.00083 19.3 0.0 0.0026 17.6 0.0 1.9 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C DRIM PF07539.12 EFC45702.1 - 0.00057 18.3 1.8 0.00089 17.7 1.8 1.2 1 0 0 1 1 1 1 Down-regulated in metastasis HEAT PF02985.22 EFC45702.1 - 0.03 14.5 0.0 2.1 8.8 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat Pkinase PF00069.25 EFC45703.1 - 1.5e-45 155.7 1.3 2.6e-45 154.9 1.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45703.1 - 2.1e-44 151.8 4.3 7.2e-42 143.4 1.2 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC45703.1 - 8.6e-05 21.6 0.6 0.0003 19.9 0.6 1.8 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC45703.1 - 0.0089 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family SieB PF14163.6 EFC45703.1 - 0.028 13.9 0.8 0.084 12.4 0.8 1.7 1 0 0 1 1 1 0 Super-infection exclusion protein B TMIE PF16038.5 EFC45703.1 - 0.048 13.5 0.1 0.15 12.0 0.1 1.8 1 0 0 1 1 1 0 TMIE protein MRF_C2 PF13888.6 EFC45703.1 - 0.075 12.9 2.3 2 8.3 0.1 3.7 3 0 0 3 3 3 0 Myelin gene regulatory factor C-terminal domain 2 FtsX PF02687.21 EFC45703.1 - 0.14 12.7 1.5 0.69 10.4 0.1 2.4 2 0 0 2 2 2 0 FtsX-like permease family Ras PF00071.22 EFC45704.1 - 8.1e-17 61.3 0.2 1.4e-16 60.5 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45704.1 - 1.6e-08 34.7 0.0 3e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC45704.1 - 1.3e-06 28.1 0.1 3.2e-06 26.8 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC45704.1 - 2.5e-05 24.2 0.0 0.00011 22.2 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase DUF3198 PF11433.8 EFC45704.1 - 0.0015 18.4 0.4 0.0047 16.8 0.4 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3198) F-box PF00646.33 EFC45704.1 - 0.013 15.4 0.3 0.036 14.0 0.3 1.8 1 0 0 1 1 1 0 F-box domain MMR_HSR1_Xtn PF16897.5 EFC45704.1 - 0.016 15.2 2.6 0.14 12.2 0.7 2.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain F-box-like PF12937.7 EFC45704.1 - 0.031 14.1 0.6 0.15 12.0 0.1 2.2 2 0 0 2 2 2 0 F-box-like DUF4116 PF13475.6 EFC45705.1 - 1.5e-206 668.1 46.4 1.6e-19 69.3 0.0 17.2 4 3 13 21 21 21 21 Domain of unknown function (DUF4116) DUF2207 PF09972.9 EFC45706.1 - 0.00012 21.0 0.3 0.00018 20.4 0.3 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) EzrA PF06160.12 EFC45706.1 - 0.0043 15.3 3.8 0.01 14.1 1.5 1.9 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA Cation_efflux PF01545.21 EFC45706.1 - 0.019 14.7 0.8 0.031 14.0 0.8 1.3 1 0 0 1 1 1 0 Cation efflux family bZIP_1 PF00170.21 EFC45706.1 - 0.22 11.6 3.5 4.7 7.4 2.1 3.3 2 2 1 3 3 3 0 bZIP transcription factor DUF3040 PF11239.8 EFC45706.1 - 1.8 8.9 4.8 4.2 7.7 4.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) AAA PF00004.29 EFC45708.1 - 3.2e-09 37.3 0.5 3.1e-08 34.1 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC45708.1 - 1.5e-05 25.4 0.0 3.9e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC45708.1 - 3.2e-05 24.2 0.0 0.00029 21.1 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 EFC45708.1 - 0.0056 17.2 0.0 0.014 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta2 PF13177.6 EFC45708.1 - 0.01 15.6 0.2 0.018 14.8 0.2 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_29 PF13555.6 EFC45708.1 - 0.012 15.4 0.0 6.7 6.5 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain RuvB_N PF05496.12 EFC45708.1 - 0.014 15.2 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 EFC45708.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFC45708.1 - 0.018 15.4 2.6 0.064 13.7 0.1 3.2 3 1 0 3 3 2 0 RNA helicase AAA_5 PF07728.14 EFC45708.1 - 0.029 14.4 0.0 0.11 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 EFC45708.1 - 0.033 13.9 0.0 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_33 PF13671.6 EFC45708.1 - 0.036 14.2 0.0 0.062 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 EFC45708.1 - 0.045 13.9 0.0 0.087 12.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 EFC45708.1 - 0.073 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_17 PF13207.6 EFC45708.1 - 0.12 12.8 0.0 0.34 11.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 EFC45708.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NACHT PF05729.12 EFC45708.1 - 0.12 12.2 0.0 0.3 11.0 0.0 1.8 1 1 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 EFC45708.1 - 0.13 12.8 0.0 0.25 11.9 0.0 1.7 1 1 0 1 1 1 0 ABC transporter Pkinase PF00069.25 EFC45709.1 - 1.7e-16 60.4 0.1 4.9e-16 58.9 0.1 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45709.1 - 2.9e-08 33.3 0.0 4.9e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45709.1 - 0.0043 15.9 0.1 0.0081 15.0 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC45709.1 - 0.02 14.8 0.1 0.034 14.1 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_8 PF13855.6 EFC45710.1 - 8.5e-25 86.3 23.0 4e-10 39.3 0.8 6.4 4 1 2 6 6 6 6 Leucine rich repeat LRR_6 PF13516.6 EFC45710.1 - 4.3e-24 82.5 23.1 0.00025 20.8 0.2 9.2 9 0 0 9 9 9 6 Leucine Rich repeat LRR_4 PF12799.7 EFC45710.1 - 1.4e-17 63.5 36.7 0.0001 22.6 0.7 7.9 4 3 5 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45710.1 - 2.7e-06 27.1 26.0 2.9 8.8 0.0 9.8 9 2 1 10 10 10 3 Leucine Rich Repeat F-box-like PF12937.7 EFC45710.1 - 0.00014 21.6 0.2 0.00031 20.6 0.2 1.6 1 0 0 1 1 1 1 F-box-like LRR_9 PF14580.6 EFC45710.1 - 0.0011 18.5 15.8 0.07 12.6 0.8 3.6 1 1 2 3 3 3 3 Leucine-rich repeat Beta_helix PF13229.6 EFC45710.1 - 7.7 6.3 10.7 3.3 7.5 4.1 2.4 1 1 0 2 2 2 0 Right handed beta helix region EGF_2 PF07974.13 EFC45712.1 - 7.1e-05 23.1 33.6 0.0033 17.8 9.7 3.0 3 0 0 3 3 3 2 EGF-like domain EGF PF00008.27 EFC45712.1 - 0.41 11.0 17.1 0.059 13.7 3.5 3.2 2 0 0 2 2 2 0 EGF-like domain LSM PF01423.22 EFC45713.1 - 1.8e-16 59.5 0.1 2.6e-16 59.1 0.1 1.3 1 0 0 1 1 1 1 LSM domain SUIM_assoc PF16619.5 EFC45713.1 - 0.035 14.2 0.3 0.039 14.0 0.3 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Polyketide_cyc2 PF10604.9 EFC45714.1 - 0.0038 17.5 0.0 0.023 14.9 0.0 1.9 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF4116 PF13475.6 EFC45715.1 - 1.9e-41 139.6 19.7 1.4e-10 40.7 0.1 5.6 2 2 5 7 7 7 7 Domain of unknown function (DUF4116) Fe_dep_repr_C PF02742.15 EFC45715.1 - 0.15 12.2 0.1 0.34 11.0 0.1 1.5 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain Herpes_UL14 PF03580.14 EFC45716.1 - 0.04 14.2 0.2 0.083 13.1 0.2 1.5 1 0 0 1 1 1 0 Herpesvirus UL14-like protein CN_hydrolase PF00795.22 EFC45718.1 - 1.8e-18 66.8 0.0 3e-18 66.1 0.0 1.3 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Ependymin PF00811.18 EFC45719.1 - 0.14 12.4 2.8 0.19 12.0 1.0 2.0 1 1 1 2 2 2 0 Ependymin DUF3638 PF12340.8 EFC45720.1 - 4e-80 268.4 2.8 2.8e-79 265.6 0.6 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 EFC45720.1 - 3.6e-15 55.0 0.0 7.5e-15 54.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) DUF1279 PF06916.13 EFC45721.1 - 2.1e-15 57.0 0.3 3.7e-15 56.2 0.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) DUF3484 PF11983.8 EFC45721.1 - 0.035 15.2 1.0 0.052 14.7 1.0 1.2 1 0 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch TRAPPC-Trs85 PF12739.7 EFC45721.1 - 0.095 11.7 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF2675 PF11247.8 EFC45721.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2675) DUF3368 PF11848.8 EFC45721.1 - 0.16 11.7 0.1 0.72 9.7 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) Pentapeptide_4 PF13599.6 EFC45722.1 - 2.3e-25 88.6 40.4 1.2e-10 41.4 2.2 3.6 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 EFC45722.1 - 1.3e-24 85.4 32.7 4.4e-10 39.0 1.6 5.7 2 2 1 5 5 5 4 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 EFC45722.1 - 4.2e-13 49.2 30.6 3.1e-07 30.4 0.7 3.9 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC45722.1 - 1.2e-11 44.8 0.0 2.3e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain DUF5077 PF16871.5 EFC45722.1 - 0.25 11.2 0.7 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5077) Tfb5 PF06331.12 EFC45722.1 - 1.6 8.8 4.1 24 5.0 0.0 3.5 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 Sel1 PF08238.12 EFC45723.1 - 0.013 16.1 0.0 0.047 14.4 0.0 1.9 1 0 0 1 1 1 0 Sel1 repeat RGS PF00615.19 EFC45724.1 - 0.00012 22.3 5.3 0.00022 21.5 5.3 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain TMEM190 PF15431.6 EFC45724.1 - 0.048 13.8 2.4 0.17 12.1 2.4 1.9 1 0 0 1 1 1 0 Transmembrane protein 190 DUF2892 PF11127.8 EFC45724.1 - 4 7.6 6.2 1 9.4 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) TLD PF07534.16 EFC45726.1 - 3.9e-23 82.2 2.2 3.9e-23 82.2 2.2 1.9 2 1 0 2 2 2 1 TLD Zip PF02535.22 EFC45726.1 - 0.87 8.7 4.0 1.1 8.4 4.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 EFC45726.1 - 1.4 7.6 10.6 2.1 7.0 10.6 1.2 1 0 0 1 1 1 0 Presenilin GAGA_bind PF06217.12 EFC45726.1 - 1.7 8.9 13.4 2.4 8.4 13.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family HSP70 PF00012.20 EFC45726.1 - 4.3 5.4 14.8 7.5 4.6 14.8 1.3 1 0 0 1 1 1 0 Hsp70 protein Macoilin PF09726.9 EFC45726.1 - 5.7 5.4 27.3 7.3 5.0 27.3 1.1 1 0 0 1 1 1 0 Macoilin family RCC1 PF00415.18 EFC45727.1 - 0.00014 22.4 1.9 10 6.9 0.1 4.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45727.1 - 0.0012 18.5 11.2 0.015 15.1 0.1 4.4 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Kelch_6 PF13964.6 EFC45727.1 - 0.034 14.4 0.5 24 5.4 0.1 3.5 3 0 0 3 3 3 0 Kelch motif TMEMspv1-c74-12 PF11044.8 EFC45728.1 - 0.46 10.5 0.1 0.46 10.5 0.1 1.9 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein ADH_zinc_N PF00107.26 EFC45729.1 - 7.8e-30 103.5 0.3 1.3e-29 102.8 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC45729.1 - 5.7e-22 79.2 0.6 1.5e-21 77.8 0.1 2.0 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC45729.1 - 1.2e-08 34.8 0.0 4.6e-08 32.9 0.0 2.1 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 EFC45729.1 - 7.9e-06 25.3 0.3 1.4e-05 24.5 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 EFC45729.1 - 0.0024 18.3 0.1 0.0041 17.5 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding NAD_kinase PF01513.21 EFC45729.1 - 0.0034 16.6 0.0 0.0048 16.1 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase 3HCDH_N PF02737.18 EFC45729.1 - 0.016 15.1 0.3 0.028 14.3 0.3 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 EFC45729.1 - 0.021 15.4 0.2 0.046 14.3 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFC45729.1 - 0.025 13.8 0.5 0.48 9.6 0.6 2.3 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 EFC45729.1 - 0.045 14.0 0.2 0.073 13.3 0.2 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_2 PF00890.24 EFC45729.1 - 0.047 12.8 0.2 0.089 11.9 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain 2-Hacid_dh_C PF02826.19 EFC45729.1 - 0.093 12.1 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 EFC45729.1 - 0.1 11.8 0.2 0.19 10.9 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 EFC45729.1 - 0.13 12.6 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain VWA_2 PF13519.6 EFC45730.1 - 1.8e-14 54.3 1.2 1.1e-13 51.8 0.1 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 EFC45730.1 - 2.1e-13 50.9 0.4 3.7e-13 50.1 0.4 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC45730.1 - 1.3e-06 28.4 0.0 2.3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC45730.1 - 0.26 10.6 0.2 0.56 9.6 0.2 1.5 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein Cu-oxidase_2 PF07731.14 EFC45731.1 - 5.5e-19 68.3 0.4 3.8e-12 46.1 1.5 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 EFC45731.1 - 2.9e-14 53.1 0.1 7.5e-07 29.2 0.0 3.6 2 1 0 2 2 2 2 Multicopper oxidase BTB_2 PF02214.22 EFC45732.1 - 7.3e-11 42.3 4.1 2.4e-09 37.4 0.0 3.5 3 0 0 3 3 3 2 BTB/POZ domain Polbeta PF18765.1 EFC45732.1 - 0.66 10.1 4.2 1.1 9.4 0.0 3.5 5 0 0 5 5 5 0 Polymerase beta, Nucleotidyltransferase EGF_2 PF07974.13 EFC45733.1 - 7.3e-37 125.4 220.3 3.2e-06 27.4 4.4 15.1 14 1 0 14 14 14 14 EGF-like domain REJ PF02010.15 EFC45733.1 - 2.3e-23 82.7 12.2 2.3e-23 82.7 12.2 1.9 2 0 0 2 2 2 1 REJ domain Peptidase_C14 PF00656.22 EFC45734.1 - 3.1e-05 24.1 0.0 4.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Caspase domain Peptidase_C13 PF01650.18 EFC45734.1 - 0.002 17.7 0.1 0.0081 15.7 0.1 2.0 1 1 0 1 1 1 1 Peptidase C13 family NARG2_C PF10505.9 EFC45735.1 - 0.019 14.5 0.0 0.039 13.5 0.0 1.5 1 0 0 1 1 1 0 NMDA receptor-regulated gene protein 2 C-terminus Actin PF00022.19 EFC45736.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin Beta-Casp PF10996.8 EFC45737.1 - 6.3e-22 78.0 0.0 1.9e-21 76.4 0.0 1.9 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EFC45737.1 - 9.8e-15 54.5 0.0 2.5e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EFC45737.1 - 8e-13 48.1 0.0 3.1e-12 46.3 0.0 2.1 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EFC45737.1 - 3.1e-08 33.9 0.0 1.2e-07 31.9 0.0 1.9 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC45737.1 - 5.5e-06 26.0 0.0 3.5e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain EMP70 PF02990.16 EFC45738.1 - 4.4e-21 75.1 13.4 4.4e-21 75.1 13.4 1.7 1 1 1 2 2 2 1 Endomembrane protein 70 CCB1 PF12046.8 EFC45738.1 - 1.2 8.5 4.9 0.23 10.8 0.4 1.8 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B Ank_5 PF13857.6 EFC45739.1 - 0.029 14.7 0.0 7.6 7.0 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC45739.1 - 0.14 12.8 0.0 24 5.7 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Peptidase_S8 PF00082.22 EFC45741.1 - 1.7e-34 119.5 4.6 2.6e-34 118.9 4.6 1.2 1 0 0 1 1 1 1 Subtilase family Palm_thioest PF02089.15 EFC45741.1 - 0.04 13.8 0.1 0.089 12.6 0.1 1.5 1 0 0 1 1 1 0 Palmitoyl protein thioesterase HTH_9 PF08221.11 EFC45742.1 - 6.6e-21 74.2 0.2 3e-17 62.5 0.0 2.7 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 EFC45742.1 - 5.4e-12 46.0 19.2 8.5e-12 45.4 9.7 3.0 2 1 0 2 2 2 2 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 EFC45742.1 - 6.3e-05 22.8 8.2 0.41 10.5 0.0 4.8 3 2 2 5 5 5 3 TFIIE alpha subunit NOC3p PF07540.11 EFC45743.1 - 3.2e-21 75.6 0.1 3.2e-21 75.6 0.1 3.6 4 1 0 4 4 4 1 Nucleolar complex-associated protein CBF PF03914.17 EFC45743.1 - 3.9e-16 59.6 0.0 3.9e-16 59.6 0.0 3.6 3 1 0 3 3 3 1 CBF/Mak21 family CDC45 PF02724.14 EFC45743.1 - 8.2e-06 24.4 1.9 8.2e-06 24.4 1.9 2.9 2 1 1 3 3 3 1 CDC45-like protein HEAT PF02985.22 EFC45743.1 - 0.0043 17.2 0.4 1.8 9.0 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat COG5 PF10392.9 EFC45744.1 - 1.2e-06 28.7 0.6 1.2e-06 28.7 0.6 3.7 4 0 0 4 4 4 2 Golgi transport complex subunit 5 CLZ PF16526.5 EFC45744.1 - 8.9e-05 22.8 0.7 8.9e-05 22.8 0.7 2.8 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Spectrin PF00435.21 EFC45744.1 - 0.036 14.5 0.3 0.24 11.9 0.3 2.5 1 0 0 1 1 1 0 Spectrin repeat Cep57_MT_bd PF06657.13 EFC45744.1 - 5.9 7.4 7.5 44 4.6 0.4 4.4 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Glyoxalase PF00903.25 EFC45745.1 - 1.3e-06 28.6 6.5 2.5e-05 24.5 0.6 3.3 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 EFC45745.1 - 9e-06 25.9 0.0 0.033 14.3 0.0 3.7 4 0 0 4 4 4 2 Glyoxalase-like domain Glyoxalase_4 PF13669.6 EFC45745.1 - 1e-05 25.7 0.5 0.0012 19.1 0.1 3.3 2 2 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily F420_oxidored PF03807.17 EFC45746.1 - 3.9e-20 72.2 0.6 6.8e-20 71.5 0.6 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFC45746.1 - 4.7e-08 33.4 0.0 1.1e-07 32.2 0.0 1.6 2 0 0 2 2 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFC45746.1 - 1.2e-07 31.3 0.2 2.6e-07 30.2 0.1 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFC45746.1 - 0.00018 21.1 0.1 0.00029 20.5 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EFC45746.1 - 0.0002 21.4 0.1 0.00043 20.3 0.1 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 EFC45746.1 - 0.00085 19.2 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 EFC45746.1 - 0.002 18.2 1.4 0.0067 16.4 0.5 2.0 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 EFC45746.1 - 0.0051 17.1 1.1 0.0088 16.3 0.5 1.8 2 0 0 2 2 2 1 TrkA-N domain ApbA PF02558.16 EFC45746.1 - 0.0053 16.4 1.3 0.014 15.1 1.3 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 EFC45746.1 - 0.0074 16.2 0.5 0.019 14.9 0.5 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 EFC45746.1 - 0.011 15.1 0.2 0.037 13.5 0.1 1.8 2 0 0 2 2 2 0 short chain dehydrogenase Pyr_redox PF00070.27 EFC45746.1 - 0.012 16.1 0.9 0.028 15.0 0.4 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_10 PF13460.6 EFC45746.1 - 0.041 13.8 0.2 0.089 12.7 0.2 1.5 1 0 0 1 1 1 0 NAD(P)H-binding XdhC_C PF13478.6 EFC45746.1 - 0.056 13.9 0.0 0.093 13.2 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain Sacchrp_dh_NADP PF03435.18 EFC45746.1 - 0.061 13.6 0.5 0.12 12.6 0.5 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 EFC45746.1 - 0.062 12.5 0.2 0.11 11.7 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GFO_IDH_MocA PF01408.22 EFC45746.1 - 0.068 14.0 0.0 0.11 13.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Glyco_transf_4 PF13439.6 EFC45746.1 - 0.094 12.7 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase Family 4 ThiF PF00899.21 EFC45746.1 - 0.16 11.3 0.5 0.32 10.3 0.5 1.4 1 0 0 1 1 1 0 ThiF family PPR PF01535.20 EFC45748.1 - 6.1e-30 101.3 27.0 0.0023 18.1 0.3 14.3 14 0 0 14 14 14 8 PPR repeat PPR_2 PF13041.6 EFC45748.1 - 1.2e-25 89.4 27.4 0.00011 22.3 0.1 10.7 8 2 2 10 10 10 8 PPR repeat family PPR_1 PF12854.7 EFC45748.1 - 5.2e-15 54.8 5.2 0.0091 15.7 0.2 7.2 7 1 1 8 8 8 3 PPR repeat PPR_3 PF13812.6 EFC45748.1 - 3.6e-12 46.2 9.1 0.00083 19.4 0.0 6.8 4 2 3 7 7 7 3 Pentatricopeptide repeat domain Clathrin PF00637.20 EFC45748.1 - 0.0072 16.2 16.7 0.38 10.6 0.0 5.5 3 2 2 5 5 5 1 Region in Clathrin and VPS TPR_7 PF13176.6 EFC45748.1 - 0.0097 15.9 1.3 1.1e+02 3.1 0.0 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45748.1 - 0.021 15.3 0.0 3 8.4 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat CDC37_C PF08564.10 EFC45748.1 - 0.067 13.3 0.2 0.35 11.0 0.2 2.2 1 0 0 1 1 1 0 Cdc37 C terminal domain Stork_head PF10264.9 EFC45748.1 - 0.1 12.8 0.3 0.56 10.4 0.1 2.5 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain ANAPC3 PF12895.7 EFC45748.1 - 0.12 12.6 1.2 0.67 10.2 0.8 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DsrC PF04358.13 EFC45748.1 - 0.32 11.5 3.6 17 6.0 0.1 3.3 3 0 0 3 3 3 0 DsrC like protein DUF2420 PF10336.9 EFC45748.1 - 2.4 8.2 7.3 1 9.4 0.2 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2420) ANAPC4_WD40 PF12894.7 EFC45749.1 - 4.7e-10 39.6 0.3 0.00016 21.9 0.0 4.7 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC45749.1 - 6.1e-10 39.5 3.0 2.3 9.2 0.0 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat PD40 PF07676.12 EFC45749.1 - 0.0019 18.1 0.3 0.56 10.2 0.0 2.8 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 EFC45749.1 - 0.025 13.7 0.1 0.14 11.2 0.1 2.1 2 0 0 2 2 2 0 Coatomer WD associated region Utp11 PF03998.13 EFC45750.1 - 2.6e-36 125.8 29.2 3e-36 125.6 29.2 1.0 1 0 0 1 1 1 1 Utp11 protein Amidinotransf PF02274.17 EFC45751.1 - 1.9e-55 188.3 3.8 1.3e-53 182.3 3.8 2.0 1 1 0 1 1 1 1 Amidinotransferase AKAP7_NLS PF10469.9 EFC45751.1 - 0.0067 16.3 0.1 0.019 14.8 0.0 1.8 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Polysacc_deac_1 PF01522.21 EFC45751.1 - 0.13 12.2 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Polysaccharide deacetylase Tropomyosin PF00261.20 EFC45752.1 - 0.002 17.6 9.0 0.0027 17.1 9.0 1.2 1 0 0 1 1 1 1 Tropomyosin DUF4618 PF15397.6 EFC45752.1 - 0.0077 15.7 5.5 0.0077 15.7 5.5 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4618) Shugoshin_N PF07558.11 EFC45752.1 - 0.013 15.4 2.1 0.22 11.4 0.1 2.5 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.15 EFC45752.1 - 0.014 15.4 1.2 0.014 15.4 1.2 2.7 3 1 0 3 3 3 0 Basic region leucine zipper ATG16 PF08614.11 EFC45752.1 - 0.017 15.3 9.4 0.023 14.9 9.4 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Vitellogenin_N PF01347.22 EFC45752.1 - 0.019 13.4 3.9 0.021 13.3 3.9 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region Laminin_II PF06009.12 EFC45752.1 - 0.031 14.3 8.9 0.15 12.1 8.9 1.9 1 1 0 1 1 1 0 Laminin Domain II Fzo_mitofusin PF04799.13 EFC45752.1 - 0.055 13.0 4.0 0.059 12.9 3.5 1.3 1 1 0 1 1 1 0 fzo-like conserved region Fib_alpha PF08702.10 EFC45752.1 - 0.055 13.6 12.2 0.14 12.3 12.2 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family HAD_2 PF13419.6 EFC45752.1 - 0.065 13.3 4.5 1.1 9.3 1.8 2.0 1 1 1 2 2 2 0 Haloacid dehalogenase-like hydrolase Herpes_IE2_3 PF03361.14 EFC45752.1 - 0.14 12.0 0.7 0.37 10.7 0.2 1.7 1 1 1 2 2 2 0 Herpes virus intermediate/early protein 2/3 DUF16 PF01519.16 EFC45752.1 - 0.19 12.2 7.9 0.34 11.4 7.7 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF16 CtIP_N PF10482.9 EFC45752.1 - 0.22 11.6 8.5 0.3 11.1 6.9 2.1 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain DUF262 PF03235.14 EFC45752.1 - 0.38 10.9 8.8 0.45 10.6 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF948 PF06103.11 EFC45752.1 - 0.52 10.6 3.5 0.84 9.9 0.2 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Golgin_A5 PF09787.9 EFC45752.1 - 0.72 9.3 11.5 0.84 9.0 11.5 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 KxDL PF10241.9 EFC45752.1 - 0.76 10.1 8.0 2.3 8.5 3.6 2.3 2 1 0 2 2 2 0 Uncharacterized conserved protein CCDC-167 PF15188.6 EFC45752.1 - 0.93 9.9 8.6 0.1 12.9 4.1 1.9 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF641 PF04859.12 EFC45752.1 - 0.93 9.8 6.1 0.67 10.3 4.6 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) TMF_DNA_bd PF12329.8 EFC45752.1 - 0.98 9.5 18.3 0.24 11.4 6.6 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Cnn_1N PF07989.11 EFC45752.1 - 1.1 9.4 13.5 0.1 12.8 4.8 2.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Med9 PF07544.13 EFC45752.1 - 1.5 9.0 10.1 0.17 12.0 4.2 2.2 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 bZIP_1 PF00170.21 EFC45752.1 - 2 8.6 11.6 0.13 12.4 3.4 2.8 2 1 1 3 3 3 0 bZIP transcription factor XhlA PF10779.9 EFC45752.1 - 2.3 8.5 8.6 0.36 11.1 3.4 2.3 2 1 0 2 2 2 0 Haemolysin XhlA DivIC PF04977.15 EFC45752.1 - 2.6 7.9 10.5 0.28 11.0 4.2 2.4 2 1 0 2 2 2 0 Septum formation initiator DUF3450 PF11932.8 EFC45752.1 - 7.1 5.9 10.7 4.9 6.4 8.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) EF-hand_1 PF00036.32 EFC45753.1 - 3.9e-25 85.5 20.0 7.1e-06 25.2 0.3 7.4 7 1 1 8 8 8 5 EF hand EF-hand_7 PF13499.6 EFC45753.1 - 2.6e-20 72.7 11.3 2.2e-05 24.8 1.9 5.3 3 2 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC45753.1 - 1.3e-17 62.1 13.8 0.00074 19.3 0.0 6.9 6 1 2 8 8 8 4 EF-hand domain EF-hand_8 PF13833.6 EFC45753.1 - 2.6e-16 59.2 10.9 3.5e-05 23.6 0.3 5.8 5 1 1 6 6 6 4 EF-hand domain pair EF-hand_5 PF13202.6 EFC45753.1 - 6.7e-16 57.0 12.9 2.6e-06 26.7 0.1 6.7 6 0 0 6 6 6 3 EF hand EF-hand_4 PF12763.7 EFC45753.1 - 8.8e-07 28.8 5.1 0.012 15.6 0.1 3.5 2 1 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC45753.1 - 0.38 11.1 3.2 14 6.0 0.2 3.2 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region adh_short PF00106.25 EFC45754.1 - 7.5e-26 90.8 0.0 9.8e-26 90.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC45754.1 - 8.7e-13 48.4 0.0 1.2e-12 47.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC45754.1 - 3.5e-07 30.3 0.0 5.8e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC45754.1 - 0.0012 18.1 0.2 0.0015 17.7 0.2 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 EFC45754.1 - 0.017 14.5 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ATP_bind_2 PF03668.15 EFC45754.1 - 0.022 14.1 0.0 0.081 12.2 0.0 1.7 2 0 0 2 2 2 0 P-loop ATPase protein family DUF5477 PF17571.2 EFC45754.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5477) DIE2_ALG10 PF04922.12 EFC45755.1 - 1.4e-101 340.6 28.9 1.9e-101 340.3 28.9 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family Ovate PF04844.13 EFC45755.1 - 0.32 11.0 2.4 4.4 7.4 0.7 2.4 2 0 0 2 2 2 0 Transcriptional repressor, ovate ARD PF03079.14 EFC45757.1 - 1.3e-39 135.9 0.1 1.5e-39 135.7 0.1 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 EFC45757.1 - 2.1e-08 33.7 0.0 3.3e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 EFC45757.1 - 9.6e-07 28.8 0.0 1.5e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_3 PF05899.12 EFC45757.1 - 0.0063 16.2 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) 3-HAO PF06052.12 EFC45757.1 - 0.017 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Cupin_8 PF13621.6 EFC45757.1 - 0.035 13.8 0.0 0.063 13.0 0.0 1.4 1 1 0 1 1 1 0 Cupin-like domain Cupin_1 PF00190.22 EFC45757.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Cupin PrgI PF12666.7 EFC45758.1 - 3.4 8.5 8.0 14 6.4 1.3 2.3 2 0 0 2 2 2 0 PrgI family protein Ras PF00071.22 EFC45759.1 - 1.4e-59 200.4 0.2 1.8e-59 200.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45759.1 - 1.5e-33 115.5 0.2 2.3e-33 114.9 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45759.1 - 1.4e-17 63.7 0.1 1.7e-17 63.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC45759.1 - 1.2e-07 31.8 0.0 2.3e-07 30.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC45759.1 - 4.4e-07 30.0 1.0 0.014 15.3 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFC45759.1 - 7e-07 28.8 0.1 8.7e-07 28.5 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EFC45759.1 - 5.8e-06 25.9 0.1 0.089 12.3 0.0 2.1 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_22 PF13401.6 EFC45759.1 - 0.00057 20.2 0.0 0.034 14.4 0.0 2.9 1 1 1 2 2 2 1 AAA domain G-alpha PF00503.20 EFC45759.1 - 0.00071 18.8 0.5 0.0035 16.5 0.5 2.2 1 1 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 EFC45759.1 - 0.0014 19.1 0.1 0.0028 18.2 0.1 1.5 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFC45759.1 - 0.0033 17.1 0.0 0.013 15.3 0.0 2.0 2 0 0 2 2 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC45759.1 - 0.0034 17.8 0.0 0.0056 17.1 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 EFC45759.1 - 0.0063 16.1 0.2 0.016 14.7 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.18 EFC45759.1 - 0.008 15.5 0.0 0.014 14.6 0.0 1.4 1 0 0 1 1 1 1 Septin DUF4080 PF13311.6 EFC45759.1 - 0.019 15.1 0.0 0.027 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4080) MCM PF00493.23 EFC45759.1 - 0.027 13.6 0.1 0.17 10.9 0.0 1.9 1 1 1 2 2 2 0 MCM P-loop domain PduV-EutP PF10662.9 EFC45759.1 - 0.037 13.8 0.1 1.1 9.0 0.1 2.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFC45759.1 - 0.044 13.5 0.5 0.11 12.2 0.5 1.9 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFC45759.1 - 0.044 13.2 0.0 0.084 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1_Xtn PF16897.5 EFC45759.1 - 0.047 13.7 0.0 0.066 13.2 0.0 1.4 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AIG1 PF04548.16 EFC45759.1 - 0.053 12.9 0.3 0.1 11.9 0.3 1.7 1 1 0 1 1 1 0 AIG1 family AAA_7 PF12775.7 EFC45759.1 - 0.083 12.4 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 EFC45759.1 - 0.084 13.3 0.0 1.4 9.3 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) bact-PGI_C PF10432.9 EFC45759.1 - 0.096 12.7 0.1 0.15 12.1 0.1 1.4 1 1 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain Alginate_lyase2 PF08787.11 EFC45760.1 - 1.5e-35 123.2 1.6 1.8e-35 122.9 1.6 1.1 1 0 0 1 1 1 1 Alginate lyase tRNA-synt_1 PF00133.22 EFC45761.1 - 1.8e-159 531.9 0.5 2.7e-159 531.2 0.5 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFC45761.1 - 7.9e-28 97.3 2.4 1.7e-27 96.3 2.4 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFC45761.1 - 2.2e-25 89.3 0.3 3e-09 36.1 0.0 4.6 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFC45761.1 - 0.00084 18.8 0.0 0.012 15.0 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EFC45761.1 - 0.0083 15.1 0.8 0.033 13.1 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class I (K) tRNA-synt_1_2 PF13603.6 EFC45761.1 - 0.053 13.0 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 DUF190 PF02641.15 EFC45761.1 - 0.15 12.4 0.4 2.5 8.5 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized ACR, COG1993 zf-FPG_IleRS PF06827.14 EFC45761.1 - 1.9 8.5 9.0 51 3.9 0.4 2.5 1 1 1 2 2 2 0 Zinc finger found in FPG and IleRS Oxysterol_BP PF01237.18 EFC45762.1 - 1.8e-63 214.6 0.0 5.7e-63 213.0 0.0 1.6 1 1 0 1 1 1 1 Oxysterol-binding protein DUF4292 PF14125.6 EFC45762.1 - 0.07 12.8 0.1 0.12 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4292) PATR PF12951.7 EFC45762.1 - 0.087 12.9 0.5 0.21 11.8 0.5 1.6 1 0 0 1 1 1 0 Passenger-associated-transport-repeat USP7_C2 PF14533.6 EFC45763.1 - 0.11 12.2 6.1 0.078 12.7 2.8 1.9 1 1 1 2 2 2 0 Ubiquitin-specific protease C-terminal Myb_DNA-bind_4 PF13837.6 EFC45763.1 - 0.37 11.2 7.0 8.9 6.8 5.3 2.6 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Csm2_III-A PF03750.13 EFC45763.1 - 0.41 11.5 4.3 0.37 11.6 3.0 1.7 1 1 0 1 1 1 0 Csm2 Type III-A Phage_holin_6_1 PF09682.10 EFC45763.1 - 0.84 10.1 8.4 0.14 12.6 1.8 2.4 1 1 2 3 3 3 0 Bacteriophage holin of superfamily 6 (Holin_LLH) FAM76 PF16046.5 EFC45763.1 - 1.2 8.5 19.6 1.5 8.2 19.6 1.1 1 0 0 1 1 1 0 FAM76 protein Neur_chan_memb PF02932.16 EFC45763.1 - 6.5 6.7 8.7 9.2 6.2 8.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3592 PF12158.8 EFC45764.1 - 6.5e-07 29.5 0.0 1.2e-06 28.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3592) RCC1 PF00415.18 EFC45765.1 - 3.2e-38 130.1 4.7 3.2e-07 30.8 0.0 7.0 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45765.1 - 9.2e-11 41.2 21.9 5.6e-06 26.0 0.2 7.3 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RFC1 PF08519.12 EFC45766.1 - 3e-44 150.9 0.4 3e-44 150.9 0.4 3.2 3 0 0 3 3 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 EFC45766.1 - 4.3e-13 49.4 0.4 8e-12 45.4 0.0 3.3 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 EFC45766.1 - 2.2e-12 47.5 0.0 5.9e-12 46.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EFC45766.1 - 6.5e-06 26.0 0.3 6.5e-06 26.0 0.3 2.8 2 0 0 2 2 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EFC45766.1 - 1e-05 25.6 0.6 1e-05 25.6 0.6 2.8 2 1 0 2 2 1 1 Rad17 P-loop domain AAA_14 PF13173.6 EFC45766.1 - 4.2e-05 23.6 0.1 0.00041 20.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFC45766.1 - 4.3e-05 23.3 0.1 8.5e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC45766.1 - 0.0011 19.2 0.0 0.0051 17.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EFC45766.1 - 0.0012 19.1 0.2 0.0012 19.1 0.2 3.5 3 0 0 3 3 2 1 AAA C-terminal domain PTCB-BRCT PF12738.7 EFC45766.1 - 0.0021 18.0 0.0 0.0068 16.3 0.0 1.9 1 0 0 1 1 1 1 twin BRCT domain RNA_helicase PF00910.22 EFC45766.1 - 0.0051 17.2 0.1 0.029 14.7 0.1 2.4 1 1 0 1 1 1 1 RNA helicase BRCT_2 PF16589.5 EFC45766.1 - 0.0078 16.6 0.0 0.062 13.7 0.0 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain AAA_16 PF13191.6 EFC45766.1 - 0.014 15.8 0.0 0.038 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 EFC45766.1 - 0.023 14.5 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 EFC45766.1 - 0.18 12.4 0.0 0.18 12.4 0.0 3.0 4 0 0 4 4 4 0 AAA domain Proteasome PF00227.26 EFC45767.1 - 2.1e-23 82.8 0.0 2.4e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Pox_A22 PF04848.13 EFC45768.1 - 0.06 13.5 0.8 0.22 11.7 0.0 2.4 3 0 0 3 3 3 0 Poxvirus A22 protein Pkinase PF00069.25 EFC45769.1 - 1.5e-45 155.6 0.3 2.6e-45 154.8 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45769.1 - 3.7e-32 111.6 0.0 6e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC45769.1 - 0.001 17.9 2.4 0.0021 16.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC45769.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFC45769.1 - 0.015 15.2 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Presenilin PF01080.17 EFC45769.1 - 8.8 5.0 6.3 13 4.4 6.3 1.2 1 0 0 1 1 1 0 Presenilin ERCC4 PF02732.15 EFC45770.1 - 9e-17 61.7 1.5 1.6e-16 60.9 0.4 2.1 2 0 0 2 2 2 1 ERCC4 domain HHH_8 PF14716.6 EFC45770.1 - 2.3e-07 31.1 0.3 1.9e-06 28.1 0.1 2.7 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH_2 PF12826.7 EFC45770.1 - 0.0068 16.5 0.1 24 5.1 0.0 3.7 4 0 0 4 4 4 2 Helix-hairpin-helix motif HTH_45 PF14947.6 EFC45770.1 - 0.055 13.5 0.1 0.14 12.1 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DEAD PF00270.29 EFC45771.1 - 5.7e-49 166.2 0.0 1e-48 165.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC45771.1 - 3.7e-27 94.9 0.0 8.3e-26 90.5 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFC45771.1 - 4.7e-17 62.0 0.1 8.5e-17 61.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFC45771.1 - 2.8e-05 24.2 0.0 8.1e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFC45771.1 - 9.1e-05 21.8 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Chordopox_A30L PF06015.12 EFC45771.1 - 0.68 9.8 0.0 0.68 9.8 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus A30L protein Zn_clus PF00172.18 EFC45773.1 - 9.7e-08 32.0 8.2 9.7e-08 32.0 8.2 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DTHCT PF08070.11 EFC45773.1 - 0.47 11.2 3.0 20 6.0 0.1 2.4 2 0 0 2 2 2 0 DTHCT (NUC029) region Vps26 PF03643.15 EFC45774.1 - 6.1e-56 189.4 0.9 1.8e-55 187.9 0.9 1.6 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 EFC45774.1 - 0.00019 21.5 0.1 0.02 14.9 0.1 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Pkinase PF00069.25 EFC45776.1 - 3.3e-55 187.3 1.3 5.9e-54 183.2 1.3 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45776.1 - 3.2e-33 115.1 0.1 3.8e-22 78.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 EFC45776.1 - 2.1e-07 30.5 0.0 5.7e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC45776.1 - 1.5e-05 23.9 0.1 1.5e-05 23.9 0.1 2.0 3 0 0 3 3 3 1 Fungal protein kinase APH PF01636.23 EFC45776.1 - 0.01 15.8 0.0 0.016 15.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFC45776.1 - 0.12 11.9 0.2 0.35 10.5 0.0 1.8 2 0 0 2 2 2 0 RIO1 family HVSL PF09749.9 EFC45777.1 - 0.00091 18.8 1.2 0.01 15.3 0.0 2.5 2 1 0 2 2 2 1 Uncharacterised conserved protein DUF3500 PF12006.8 EFC45777.1 - 0.061 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) E1-E2_ATPase PF00122.20 EFC45778.1 - 2.8e-44 150.8 1.0 2.8e-44 150.8 1.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 EFC45778.1 - 1.9e-43 146.7 16.0 1.4e-13 51.0 0.6 4.7 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 EFC45778.1 - 2.3e-37 129.3 0.0 3.8e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC45778.1 - 0.0009 19.1 0.1 0.0009 19.1 0.1 3.3 4 0 0 4 4 4 1 haloacid dehalogenase-like hydrolase DAHP_snth_FXD PF18152.1 EFC45778.1 - 0.0014 18.4 0.3 0.032 14.0 0.0 3.2 4 0 0 4 4 4 1 DAHP synthase ferredoxin-like domain HAD PF12710.7 EFC45778.1 - 0.0081 16.6 0.0 0.025 15.0 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2721 PF11026.8 EFC45778.1 - 0.011 15.6 0.3 0.011 15.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Fer2_BFD PF04324.15 EFC45778.1 - 6.8 7.1 23.4 2 8.9 0.0 5.6 6 0 0 6 6 6 0 BFD-like [2Fe-2S] binding domain EF-hand_1 PF00036.32 EFC45779.1 - 5.7e-24 81.8 6.4 5.8e-07 28.6 0.0 3.9 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC45779.1 - 7.8e-21 74.3 1.1 1.6e-14 54.1 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC45779.1 - 1.1e-19 68.6 4.3 3.8e-06 26.4 0.0 4.0 4 1 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFC45779.1 - 1.5e-16 59.0 6.9 2.8e-05 23.4 0.1 3.8 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EFC45779.1 - 3.1e-11 43.4 0.2 1.3e-05 25.5 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFC45779.1 - 8.1e-11 41.6 6.5 0.00013 21.7 0.8 3.6 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC45779.1 - 3e-05 24.3 0.0 0.0069 16.7 0.0 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC45779.1 - 8.9e-05 22.4 2.9 0.018 15.0 1.3 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 EFC45779.1 - 9.5e-05 22.5 2.9 0.23 11.7 0.0 2.9 2 1 1 3 3 3 2 Dockerin type I domain Caleosin PF05042.13 EFC45779.1 - 0.089 12.7 0.2 6 6.8 0.0 2.6 2 1 1 3 3 3 0 Caleosin related protein DUF2492 PF10678.9 EFC45779.1 - 0.18 12.1 1.6 1.1 9.6 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2492) CH_2 PF06294.11 EFC45780.1 - 1.4e-34 118.1 1.8 3.6e-34 116.7 0.0 2.1 2 0 0 2 2 2 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFC45780.1 - 7.6e-18 64.1 0.0 1.4e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain CH PF00307.31 EFC45780.1 - 4.2e-05 23.7 0.3 9.9e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Calponin homology (CH) domain DUF641 PF04859.12 EFC45780.1 - 0.017 15.4 0.7 0.017 15.4 0.7 2.3 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) DUF16 PF01519.16 EFC45780.1 - 0.22 12.0 5.6 0.087 13.3 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 PKcGMP_CC PF16808.5 EFC45780.1 - 0.33 10.8 8.3 2.1 8.3 4.1 2.6 1 1 1 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Cep57_CLD PF14073.6 EFC45780.1 - 1.1 9.3 11.0 4.7 7.2 11.0 1.9 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 NUDIX PF00293.28 EFC45781.1 - 5.3e-19 68.6 0.0 8.6e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Atx10homo_assoc PF09759.9 EFC45782.1 - 7.5e-33 112.5 0.4 2e-32 111.1 0.4 1.8 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain AMP-binding PF00501.28 EFC45783.1 - 3.5e-46 157.7 0.0 5.1e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFC45783.1 - 2.1e-30 105.8 0.0 4.3e-30 104.8 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFC45783.1 - 7.2e-09 35.5 0.0 1.2e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 EFC45783.1 - 5.4e-05 23.5 0.0 0.00018 21.8 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site GDP_Man_Dehyd PF16363.5 EFC45783.1 - 0.00041 19.9 0.0 0.0021 17.5 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Ofd1_CTDD PF10637.9 EFC45784.1 - 2.3e-41 141.8 9.6 1.8e-36 125.8 0.1 3.7 3 2 0 3 3 3 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 EFC45784.1 - 2.5e-24 85.7 0.0 2.1e-22 79.6 0.0 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EFC45784.1 - 5.3e-15 56.1 0.0 1.1e-14 55.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ustilago_mating PF05722.12 EFC45784.1 - 0.29 10.6 0.5 4.5 6.7 0.4 2.1 2 0 0 2 2 2 0 Ustilago B locus mating-type protein DUF3139 PF11337.8 EFC45784.1 - 5.4 7.7 6.1 6.1 7.6 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3139) DUF4119 PF13494.6 EFC45784.1 - 9.5 6.4 7.9 1.3 9.2 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF4119) SAYSvFN PF10260.9 EFC45785.1 - 1.3e-21 76.2 0.5 1.9e-21 75.7 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) Bax1-I PF01027.20 EFC45786.1 - 2.7e-27 96.0 22.5 3.1e-27 95.7 22.5 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 YpmT PF17431.2 EFC45786.1 - 0.25 11.4 4.0 8.4 6.5 1.1 2.8 2 1 0 2 2 2 0 Uncharacterized YmpT-like Bromodomain PF00439.25 EFC45787.1 - 5e-25 87.4 0.5 9.9e-25 86.4 0.5 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 EFC45787.1 - 1.3e-11 44.8 0.0 2.3e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC45787.1 - 2.2e-08 34.1 0.1 4.1e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC45787.1 - 2.3e-05 24.7 0.3 4.6e-05 23.8 0.3 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain COS PF18568.1 EFC45787.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 TRIM C-terminal subgroup One Signature domain AAA PF00004.29 EFC45788.1 - 6.5e-44 149.6 0.2 2.7e-43 147.5 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC45788.1 - 2.2e-10 40.2 0.0 5e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 EFC45788.1 - 1.2e-08 34.8 0.1 3e-08 33.5 0.0 1.7 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 EFC45788.1 - 2.8e-08 33.8 0.1 8.7e-08 32.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFC45788.1 - 4.7e-08 33.3 0.0 1.1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFC45788.1 - 4.9e-07 30.3 0.3 9e-05 22.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFC45788.1 - 3.2e-05 24.2 0.9 0.0084 16.4 0.1 2.6 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 EFC45788.1 - 4.3e-05 22.8 0.0 8.3e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 EFC45788.1 - 0.0002 21.9 0.0 0.00073 20.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 EFC45788.1 - 0.00026 20.8 0.0 0.00063 19.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 EFC45788.1 - 0.00066 20.0 0.0 0.0013 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 EFC45788.1 - 0.00075 19.3 0.0 0.0018 18.0 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein NTPase_1 PF03266.15 EFC45788.1 - 0.0011 18.9 0.3 0.029 14.3 0.0 2.8 3 0 0 3 3 3 1 NTPase RNA_helicase PF00910.22 EFC45788.1 - 0.0016 18.8 0.0 0.0038 17.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 EFC45788.1 - 0.0016 17.9 0.1 0.0036 16.7 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 EFC45788.1 - 0.003 16.8 0.0 0.0063 15.8 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 EFC45788.1 - 0.0041 16.7 1.6 0.033 13.8 1.2 2.2 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 EFC45788.1 - 0.0041 17.3 0.0 0.0082 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC45788.1 - 0.0067 16.2 0.1 0.015 15.0 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFC45788.1 - 0.0069 16.4 0.1 0.032 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFC45788.1 - 0.0075 16.0 0.2 0.019 14.7 0.2 1.8 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 EFC45788.1 - 0.0075 16.3 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFC45788.1 - 0.0086 15.6 0.1 0.06 12.9 0.1 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 EFC45788.1 - 0.011 15.6 0.5 0.081 12.8 0.1 2.4 3 0 0 3 3 2 0 NACHT domain Parvo_NS1 PF01057.17 EFC45788.1 - 0.014 14.5 0.0 0.033 13.3 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 EFC45788.1 - 0.017 15.0 0.0 0.064 13.1 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC45788.1 - 0.017 14.9 0.2 0.18 11.5 0.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain ATPase PF06745.13 EFC45788.1 - 0.024 14.0 1.7 0.4 10.0 0.0 2.7 3 0 0 3 3 3 0 KaiC TniB PF05621.11 EFC45788.1 - 0.039 13.4 0.0 2.1 7.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_11 PF13086.6 EFC45788.1 - 0.042 13.6 0.3 0.32 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 EFC45788.1 - 0.068 13.3 0.1 1.2 9.2 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 EFC45788.1 - 0.096 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 EFC45788.1 - 0.18 12.1 0.2 0.55 10.6 0.1 1.8 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.22 EFC45788.1 - 0.26 10.4 1.5 0.47 9.6 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EFC45788.1 - 0.33 10.8 2.7 2.1 8.2 0.0 2.8 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Dr_adhesin PF12393.8 EFC45789.1 - 0.025 14.8 0.3 0.062 13.6 0.3 1.7 1 0 0 1 1 1 0 Dr family adhesin Nop14 PF04147.12 EFC45789.1 - 2.2 6.4 15.3 3.5 5.7 15.3 1.3 1 0 0 1 1 1 0 Nop14-like family TFIIA PF03153.13 EFC45789.1 - 8.8 6.2 30.0 12 5.8 30.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MPC PF03650.13 EFC45790.1 - 9.7e-33 112.6 0.0 1e-32 112.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DnaJ PF00226.31 EFC45791.1 - 1e-12 48.0 0.6 1e-12 48.0 0.6 2.6 3 0 0 3 3 3 1 DnaJ domain DUF4400 PF14348.6 EFC45791.1 - 0.19 11.2 0.1 0.19 11.2 0.1 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4400) DUF745 PF05335.13 EFC45791.1 - 1.7 8.3 4.2 0.42 10.3 0.2 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF745) Chordopox_L2 PF05803.12 EFC45792.1 - 0.0033 17.2 2.4 0.012 15.5 2.4 1.9 1 0 0 1 1 1 1 Chordopoxvirus L2 protein DUF3211 PF11485.8 EFC45793.1 - 0.03 14.5 2.7 0.32 11.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3211) Chordopox_G3 PF06129.12 EFC45793.1 - 0.082 13.6 0.3 0.25 12.0 0.3 1.8 1 0 0 1 1 1 0 Chordopoxvirus G3 protein V-set PF07686.17 EFC45793.1 - 0.15 12.2 0.2 0.44 10.7 0.2 1.7 1 0 0 1 1 1 0 Immunoglobulin V-set domain AAA PF00004.29 EFC45794.1 - 2.6e-27 95.9 0.8 2.2e-17 63.7 0.2 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFC45794.1 - 9.7e-07 29.2 0.0 0.002 18.5 0.0 2.9 2 0 0 2 2 2 2 RNA helicase Zot PF05707.12 EFC45794.1 - 3.1e-06 27.0 0.5 0.00062 19.5 0.0 3.4 2 2 1 3 3 3 1 Zonular occludens toxin (Zot) IstB_IS21 PF01695.17 EFC45794.1 - 5.3e-06 26.3 0.1 0.11 12.2 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 EFC45794.1 - 1.9e-05 24.3 0.7 0.00027 20.5 0.1 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 EFC45794.1 - 2.2e-05 25.0 0.0 0.16 12.5 0.0 2.9 2 0 0 2 2 2 2 ABC transporter Sigma54_activ_2 PF14532.6 EFC45794.1 - 4.5e-05 23.6 0.2 0.053 13.6 0.0 3.0 3 0 0 3 3 2 1 Sigma-54 interaction domain AAA_5 PF07728.14 EFC45794.1 - 6.4e-05 23.0 0.1 0.00082 19.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC45794.1 - 0.00012 22.4 0.0 0.0015 18.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 EFC45794.1 - 0.00012 22.1 1.4 0.0078 16.2 0.1 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RsgA_GTPase PF03193.16 EFC45794.1 - 0.00027 20.9 0.9 0.031 14.2 0.0 2.8 3 0 0 3 3 2 1 RsgA GTPase Sigma54_activat PF00158.26 EFC45794.1 - 0.00031 20.5 0.3 0.047 13.4 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_16 PF13191.6 EFC45794.1 - 0.00036 21.0 0.0 0.014 15.8 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 EFC45794.1 - 0.00045 20.4 0.5 0.0034 17.5 0.1 2.6 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFC45794.1 - 0.0012 18.7 0.0 0.1 12.3 0.0 2.9 2 1 1 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain KAP_NTPase PF07693.14 EFC45794.1 - 0.0052 16.1 0.0 0.023 13.9 0.0 2.0 1 1 0 1 1 1 1 KAP family P-loop domain AAA_25 PF13481.6 EFC45794.1 - 0.0071 15.9 0.0 0.28 10.7 0.0 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 EFC45794.1 - 0.0075 15.5 0.2 0.26 10.5 0.0 2.4 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_24 PF13479.6 EFC45794.1 - 0.0077 16.0 0.1 0.052 13.3 0.0 2.5 3 1 0 3 3 2 1 AAA domain Bac_DnaA PF00308.18 EFC45794.1 - 0.0092 15.8 1.5 0.037 13.8 0.5 2.3 2 1 0 2 2 2 1 Bacterial dnaA protein T2SSE PF00437.20 EFC45794.1 - 0.011 14.8 0.0 0.18 10.8 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Torsin PF06309.11 EFC45794.1 - 0.018 15.1 0.2 0.33 11.0 0.0 2.6 2 0 0 2 2 2 0 Torsin AAA_18 PF13238.6 EFC45794.1 - 0.024 15.2 0.0 0.82 10.2 0.0 3.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 EFC45794.1 - 0.067 12.6 0.0 0.16 11.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 EFC45794.1 - 0.086 12.8 0.1 0.47 10.4 0.0 2.5 2 0 0 2 2 1 0 NACHT domain Mg_chelatase PF01078.21 EFC45794.1 - 0.091 12.1 0.3 0.3 10.4 0.1 2.0 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI APS_kinase PF01583.20 EFC45794.1 - 0.12 12.3 0.1 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF4914 PF16260.5 EFC45794.1 - 0.12 10.5 0.0 0.18 9.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) DUF815 PF05673.13 EFC45794.1 - 0.23 10.6 2.9 0.57 9.3 0.1 2.7 2 1 0 3 3 3 0 Protein of unknown function (DUF815) ATPase PF06745.13 EFC45794.1 - 0.32 10.3 2.1 2.2 7.6 0.0 3.2 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 EFC45794.1 - 2.1 8.2 7.1 0.28 11.1 0.3 3.0 3 2 0 3 3 3 0 ATPase domain predominantly from Archaea PAS_9 PF13426.7 EFC45795.1 - 1.3e-10 41.5 0.0 4.3e-10 39.8 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC45795.1 - 5.9e-08 32.7 0.0 2.2e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 PAS fold PH PF00169.29 EFC45795.1 - 9.4e-07 29.3 2.0 9.4e-07 29.3 2.0 2.8 3 1 1 4 4 4 1 PH domain PAS_4 PF08448.10 EFC45795.1 - 0.00034 20.8 0.0 0.0012 19.1 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC45795.1 - 0.005 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 EFC45795.1 - 0.11 12.8 0.0 0.51 10.7 0.0 2.2 1 0 0 1 1 1 0 PAS fold PH PF00169.29 EFC45796.1 - 4.6e-15 56.0 0.4 4.6e-15 56.0 0.4 2.0 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 EFC45796.1 - 1.1e-05 25.8 1.7 1.1e-05 25.8 1.7 3.4 2 2 0 2 2 2 1 Pleckstrin homology domain Herpes_U5 PF05999.11 EFC45796.1 - 0.015 14.1 0.1 0.02 13.7 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus U5-like family Baculo_PEP_C PF04513.12 EFC45796.1 - 0.31 11.1 5.3 2.2 8.3 0.0 2.3 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Lectin_N PF03954.14 EFC45796.1 - 0.96 9.2 18.0 4.2 7.1 5.6 3.2 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Atg14 PF10186.9 EFC45796.1 - 3 6.8 18.8 4.1 6.4 18.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 EFC45796.1 - 3.1 8.0 28.3 0.38 11.0 16.5 2.7 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4665 PF15679.5 EFC45796.1 - 3.3 8.4 19.8 4.7 7.9 6.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4665) LRR_4 PF12799.7 EFC45798.1 - 5.4e-15 55.3 21.2 0.00017 21.9 5.3 5.4 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC45798.1 - 7.7e-13 47.4 20.0 0.0014 18.6 0.3 7.7 8 0 0 8 8 8 5 Leucine Rich repeat LRR_8 PF13855.6 EFC45798.1 - 2e-08 33.9 20.5 0.0047 16.7 0.1 5.6 4 2 0 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC45798.1 - 8.2e-06 25.7 13.4 14 6.7 0.2 8.0 8 1 0 8 8 8 2 Leucine Rich Repeat Peptidase_M15_2 PF05951.13 EFC45799.1 - 0.0017 18.1 1.5 0.014 15.1 0.1 3.0 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF882) SAM_2 PF07647.17 EFC45799.1 - 0.0097 16.0 0.0 0.029 14.5 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WASH-7_mid PF14744.6 EFC45800.1 - 4e-146 486.6 5.5 4e-146 486.6 5.5 2.2 3 0 0 3 3 3 1 WASH complex subunit 7 WASH-7_N PF14745.6 EFC45800.1 - 3.4e-113 379.1 11.2 3.4e-113 379.1 11.2 2.0 2 0 0 2 2 2 1 WASH complex subunit 7, N-terminal WASH-7_C PF14746.6 EFC45800.1 - 3.1e-61 206.1 9.5 8e-61 204.8 9.5 1.8 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal Mito_carr PF00153.27 EFC45801.1 - 7.6e-46 154.0 3.9 3.4e-16 58.9 0.5 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 EFC45802.1 - 4.2e-09 36.2 0.1 3.9e-06 26.7 0.1 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein Coiled-coil_56 PF09813.9 EFC45803.1 - 4.8e-05 23.3 0.1 0.00011 22.1 0.1 1.6 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 56 Cyt_b-c1_8 PF10890.8 EFC45803.1 - 0.056 13.9 0.0 0.083 13.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 PHtD_u1 PF16645.5 EFC45803.1 - 0.08 13.4 2.3 0.13 12.7 2.3 1.6 1 1 0 1 1 1 0 Unstructured region on Pneumococcal histidine triad protein HMG_box PF00505.19 EFC45805.1 - 1.1e-13 51.4 2.5 3.1e-13 49.9 2.5 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC45805.1 - 9.5e-09 35.7 3.1 4.3e-08 33.6 3.1 2.2 1 0 0 1 1 1 1 HMG-box domain PCNA_N PF00705.18 EFC45806.1 - 2.1e-07 30.7 0.3 5.8e-07 29.3 0.3 1.8 1 1 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.16 EFC45806.1 - 2.6e-05 23.4 0.3 3.1e-05 23.2 0.3 1.2 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 PCNA_C PF02747.15 EFC45806.1 - 0.00012 22.2 0.2 0.0013 18.9 0.0 2.9 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Peptidase_M60_C PF18630.1 EFC45806.1 - 0.21 11.8 0.8 0.64 10.2 0.1 2.1 2 0 0 2 2 2 0 Peptidase M60 C-terminal domain CRAM_rpt PF07016.11 EFC45807.1 - 0.2 11.5 0.2 0.37 10.6 0.2 1.4 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor DEAD PF00270.29 EFC45808.1 - 1.8e-19 70.1 0.0 6.2e-19 68.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC45808.1 - 1.4e-17 64.0 0.0 5.7e-17 62.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 EFC45808.1 - 7.4e-13 49.0 9.2 7.4e-13 49.0 9.2 2.1 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 EFC45808.1 - 6.2e-07 29.6 0.0 5.5e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Rhodanese PF00581.20 EFC45808.1 - 0.0043 17.6 0.1 0.25 11.9 0.0 2.4 2 0 0 2 2 2 1 Rhodanese-like domain SecA_DEAD PF07517.14 EFC45808.1 - 0.016 14.5 0.0 5.3 6.3 0.0 2.4 2 0 0 2 2 2 0 SecA DEAD-like domain CdiI_N PF18228.1 EFC45808.1 - 0.14 12.0 0.1 0.36 10.7 0.1 1.6 1 0 0 1 1 1 0 CdiI N-terminal domain TPR_2 PF07719.17 EFC45810.1 - 1.1e-05 25.2 5.0 0.0076 16.3 0.3 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC45810.1 - 3.4e-05 24.2 0.6 0.082 13.6 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45810.1 - 6.1e-05 23.5 0.2 0.36 11.4 0.1 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC45810.1 - 0.00016 21.4 6.8 0.0016 18.1 0.8 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC45810.1 - 0.00034 20.8 0.4 0.0049 17.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC45810.1 - 0.011 15.3 1.1 4.6 7.0 0.1 2.7 2 0 0 2 2 2 0 TPR repeat DUF4407 PF14362.6 EFC45810.1 - 0.014 14.8 0.4 0.028 13.8 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ANAPC3 PF12895.7 EFC45810.1 - 0.027 14.7 2.7 0.17 12.1 0.2 2.7 2 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Yop-YscD_ppl PF16693.5 EFC45810.1 - 0.089 12.2 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Inner membrane component of T3SS, periplasmic domain TPR_7 PF13176.6 EFC45810.1 - 0.24 11.5 0.8 1.5 9.1 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Methyltransf_21 PF05050.12 EFC45811.1 - 0.00014 21.9 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain HMG_box PF00505.19 EFC45812.1 - 1e-13 51.4 0.3 2.3e-13 50.4 0.3 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC45812.1 - 5.6e-09 36.5 0.3 1.1e-08 35.6 0.3 1.5 1 0 0 1 1 1 1 HMG-box domain MgtE PF01769.16 EFC45812.1 - 0.022 15.1 7.9 0.049 14.0 0.8 2.3 2 0 0 2 2 2 0 Divalent cation transporter DUF5345 PF17280.2 EFC45812.1 - 0.31 11.0 0.1 0.31 11.0 0.1 3.2 4 0 0 4 4 4 0 Family of unknown function (DUF5345) AF-4 PF05110.13 EFC45812.1 - 2.2 6.3 13.4 3.1 5.8 13.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SPX PF03105.19 EFC45812.1 - 3.2 7.6 10.0 1.2 9.0 2.1 2.6 3 0 0 3 3 3 0 SPX domain Barttin PF15462.6 EFC45812.1 - 6.6 6.4 6.9 1.9 8.2 3.3 1.8 2 0 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) DUF4394 PF14339.6 EFC45813.1 - 0.021 14.2 0.2 0.082 12.3 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4394) SUR7 PF06687.12 EFC45814.1 - 0.0014 18.3 1.1 0.0017 18.1 1.1 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2370 PF10176.9 EFC45814.1 - 0.03 14.0 0.1 0.042 13.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) GWT1 PF06423.12 EFC45814.1 - 0.059 13.5 0.5 0.072 13.2 0.5 1.2 1 0 0 1 1 1 0 GWT1 PEN-2 PF10251.9 EFC45814.1 - 0.062 13.7 1.8 0.11 12.9 1.8 1.4 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase CrgA PF06781.12 EFC45814.1 - 0.072 13.1 0.5 0.23 11.6 0.5 1.9 1 1 0 1 1 1 0 Cell division protein CrgA DUF2407_C PF13373.6 EFC45814.1 - 0.1 12.8 0.0 0.15 12.3 0.0 1.3 1 1 0 1 1 1 0 DUF2407 C-terminal domain DUF2116 PF09889.9 EFC45814.1 - 0.14 12.2 2.5 3.9 7.5 0.1 3.0 3 0 0 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) E1-E2_ATPase PF00122.20 EFC45814.1 - 0.15 11.6 0.3 0.2 11.1 0.3 1.3 1 0 0 1 1 1 0 E1-E2 ATPase UL45 PF05473.12 EFC45814.1 - 0.62 9.7 2.3 12 5.4 1.2 2.1 1 1 1 2 2 2 0 UL45 protein, carbohydrate-binding C-type lectin-like DHHC PF01529.20 EFC45814.1 - 1 9.5 6.1 1.7 8.8 6.0 1.5 1 1 0 1 1 1 0 DHHC palmitoyltransferase DUF202 PF02656.15 EFC45814.1 - 1.1 9.8 3.9 1.6 9.2 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) DUF3664 PF12406.8 EFC45814.1 - 1.5 9.5 8.1 1.9 9.1 8.1 1.1 1 0 0 1 1 1 0 Surface protein RtcB PF01139.17 EFC45815.1 - 1.8e-79 267.8 0.0 4.3e-79 266.6 0.0 1.6 1 1 0 1 1 1 1 tRNA-splicing ligase RtcB KHA PF11834.8 EFC45815.1 - 0.032 14.3 0.1 0.14 12.3 0.1 2.1 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel DUF3972 PF13118.6 EFC45815.1 - 0.045 14.2 1.0 1.5 9.2 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3972) GCV_T PF01571.21 EFC45816.1 - 9.8e-77 257.8 0.0 1.3e-76 257.4 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 EFC45816.1 - 1e-17 63.8 0.0 2.6e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Fz PF01392.22 EFC45817.1 - 0.0007 20.2 10.7 0.0007 20.2 10.7 2.5 2 1 0 2 2 2 1 Fz domain PatG_C PF18065.1 EFC45818.1 - 0.032 14.2 0.1 0.073 13.0 0.1 1.6 1 0 0 1 1 1 0 PatG C-terminal Lyase_N PF09092.11 EFC45819.1 - 0.02 14.7 0.2 0.072 12.9 0.1 1.8 2 1 0 2 2 2 0 Lyase, N terminal ELM2 PF01448.24 EFC45820.1 - 2.7 8.8 0.0 2.7 8.8 0.0 3.5 4 0 0 4 4 4 0 ELM2 domain Erf4 PF10256.9 EFC45821.1 - 0.00092 19.3 1.2 1.3 9.1 0.1 2.8 2 1 0 2 2 2 2 Golgin subfamily A member 7/ERF4 family UbiA PF01040.18 EFC45821.1 - 0.028 13.7 1.8 0.032 13.5 0.1 1.9 3 0 0 3 3 3 0 UbiA prenyltransferase family CLTH PF10607.9 EFC45821.1 - 0.04 13.8 0.2 3.3 7.6 0.0 2.2 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Sigma_reg_N PF13800.6 EFC45821.1 - 0.087 13.1 3.1 2.1 8.7 0.1 2.4 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Claudin_3 PF06653.11 EFC45821.1 - 0.087 12.8 4.9 1.3 9.0 1.1 2.2 2 0 0 2 2 2 0 Tight junction protein, Claudin-like DUF5305 PF17231.2 EFC45821.1 - 0.16 11.3 1.3 8.6 5.7 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5305) Orf78 PF06024.12 EFC45821.1 - 0.2 12.0 4.2 10 6.5 0.1 2.3 2 0 0 2 2 2 0 Orf78 (ac78) DUF2207 PF09972.9 EFC45821.1 - 0.37 9.5 4.1 2 7.1 4.1 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) TPR_8 PF13181.6 EFC45822.1 - 5.7e-14 51.1 15.6 0.0015 18.6 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC45822.1 - 5e-13 48.1 17.1 0.00049 20.0 0.1 8.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC45822.1 - 8.8e-12 44.3 11.8 0.00051 19.7 0.1 7.4 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC45822.1 - 6.4e-11 41.9 3.6 0.061 13.7 0.0 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC45822.1 - 2.9e-08 33.3 1.4 0.073 12.8 0.1 5.4 4 1 1 5 5 5 2 TPR repeat TPR_12 PF13424.6 EFC45822.1 - 5.1e-08 33.1 7.6 0.0035 17.6 0.2 5.0 4 2 1 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC45822.1 - 6.7e-08 32.6 0.1 0.0025 17.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC45822.1 - 3.7e-06 27.5 0.2 0.00066 20.3 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC45822.1 - 2.6e-05 24.6 0.1 1.4 9.7 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC45822.1 - 7.6e-05 23.1 0.5 0.025 15.1 0.1 3.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC45822.1 - 0.0003 21.3 0.2 38 5.5 0.0 5.6 4 2 3 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45822.1 - 0.73 10.1 7.8 0.52 10.6 0.2 3.7 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_7 PF13499.6 EFC45823.1 - 5.4e-13 49.2 5.1 5.8e-10 39.5 2.5 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC45823.1 - 6.7e-13 47.2 1.2 1.3e-06 27.5 0.3 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC45823.1 - 1.9e-11 43.6 1.5 9.1e-06 25.4 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC45823.1 - 2.3e-09 36.3 0.6 0.00012 21.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFC45823.1 - 1.4e-08 34.0 0.4 0.00085 19.1 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC45823.1 - 0.00032 21.0 10.2 0.11 12.8 0.7 3.2 2 1 1 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EFC45823.1 - 0.0037 17.4 0.0 2.5 8.4 0.0 2.3 2 0 0 2 2 2 2 Dockerin type I domain EF-hand_10 PF14788.6 EFC45823.1 - 0.0069 16.2 2.7 0.93 9.4 0.1 3.3 2 1 1 3 3 3 1 EF hand Spot_14 PF07084.12 EFC45823.1 - 0.15 12.2 7.9 0.16 12.1 6.8 1.6 1 1 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 CNDH2_N PF06278.11 EFC45823.1 - 7.2 6.9 11.5 1.8e+02 2.3 11.5 2.3 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF4611 PF15387.6 EFC45823.1 - 8.3 6.7 14.3 15 5.8 13.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) PBECR3 PF18812.1 EFC45825.1 - 0.26 11.3 3.3 0.99 9.4 3.3 2.0 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 Pkinase PF00069.25 EFC45826.1 - 0.023 14.0 0.0 0.042 13.2 0.0 1.3 1 1 0 1 1 1 0 Protein kinase domain G8 PF10162.9 EFC45827.1 - 2.8e-17 62.9 0.0 6.1e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 G8 domain Beta_helix PF13229.6 EFC45827.1 - 0.055 13.3 12.5 0.1 12.5 0.4 3.7 3 1 0 3 3 3 0 Right handed beta helix region CHRD PF07452.12 EFC45827.1 - 0.065 14.2 0.0 0.23 12.4 0.0 2.0 1 0 0 1 1 1 0 CHRD domain OCRE PF17780.1 EFC45827.1 - 0.26 11.3 6.2 0.11 12.6 0.9 2.7 2 0 0 2 2 2 0 OCRE domain F-box PF00646.33 EFC45828.1 - 0.0016 18.2 0.2 0.0083 16.0 0.2 2.3 1 0 0 1 1 1 1 F-box domain Orn_Arg_deC_N PF02784.16 EFC45829.1 - 1.5e-55 188.3 0.1 1.6e-41 142.3 0.0 2.3 2 0 0 2 2 2 2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFC45829.1 - 2.7e-17 62.8 0.0 6.8e-17 61.5 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain zf-trcl PF13451.6 EFC45829.1 - 0.0064 16.4 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Probable zinc-ribbon domain DUF5032 PF16435.5 EFC45829.1 - 0.022 14.2 0.5 5.2 6.5 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5032) MMR_HSR1 PF01926.23 EFC45830.1 - 5.7e-06 26.4 0.8 1.3e-05 25.2 0.1 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC45830.1 - 0.00028 20.6 0.0 0.00089 18.9 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC45830.1 - 0.0008 19.4 2.9 0.0018 18.2 0.2 2.5 2 1 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 EFC45830.1 - 0.0011 18.3 0.2 0.0025 17.2 0.0 1.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family T2SSE PF00437.20 EFC45830.1 - 0.0034 16.5 0.1 0.0076 15.3 0.1 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein GTP_EFTU PF00009.27 EFC45830.1 - 0.0073 15.9 1.8 0.023 14.3 0.4 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EFC45830.1 - 0.0098 16.3 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 EFC45830.1 - 0.025 15.1 17.3 0.011 16.3 13.9 2.2 1 1 1 2 2 2 0 AAA domain cobW PF02492.19 EFC45830.1 - 0.037 13.6 0.1 0.08 12.5 0.1 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Peptidase_S49 PF01343.18 EFC45830.1 - 0.1 12.5 0.3 0.22 11.5 0.3 1.5 1 0 0 1 1 1 0 Peptidase family S49 Dynamin_N PF00350.23 EFC45830.1 - 1.7 8.6 15.4 4.1 7.4 0.1 4.3 3 2 1 4 4 4 0 Dynamin family ABC_tran PF00005.27 EFC45830.1 - 2.3 8.7 9.9 1.3 9.5 6.2 2.6 2 1 0 2 2 2 0 ABC transporter Dicty_REP PF05086.12 EFC45831.1 - 4.3 5.2 23.9 4.8 5.0 23.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ABC_tran PF00005.27 EFC45832.1 - 1.3e-21 77.6 0.0 2.3e-21 76.8 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 EFC45832.1 - 4.1e-12 46.0 18.9 4.1e-12 46.0 18.9 3.3 4 0 0 4 4 4 1 ABC-2 type transporter AAA_22 PF13401.6 EFC45832.1 - 7e-05 23.1 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 EFC45832.1 - 0.00046 19.4 22.9 0.00046 19.4 22.9 3.1 3 0 0 3 3 3 1 ABC-2 family transporter protein AAA_16 PF13191.6 EFC45832.1 - 0.0022 18.4 0.0 0.004 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 EFC45832.1 - 0.0031 17.1 0.0 0.0053 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 EFC45832.1 - 0.0035 17.9 0.0 0.0078 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 EFC45832.1 - 0.014 15.4 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 EFC45832.1 - 0.015 15.2 0.3 0.65 9.9 0.2 2.7 2 0 0 2 2 2 0 NACHT domain SMC_N PF02463.19 EFC45832.1 - 0.017 14.6 0.6 0.14 11.6 0.6 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC45832.1 - 0.017 15.0 0.2 0.037 13.9 0.2 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_24 PF13479.6 EFC45832.1 - 0.029 14.1 0.1 0.059 13.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC45832.1 - 0.038 13.7 0.2 0.092 12.5 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain PRK PF00485.18 EFC45832.1 - 0.14 11.9 0.6 0.34 10.6 0.6 1.6 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATPase PF06745.13 EFC45832.1 - 0.14 11.4 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 KaiC TMEM132D_C PF15706.5 EFC45832.1 - 0.61 9.9 5.6 2.4 8.0 0.9 2.7 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Transglut_core PF01841.19 EFC45833.1 - 3.2e-06 27.6 0.1 8e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily Guanylate_cyc PF00211.20 EFC45834.1 - 6.4e-44 149.8 0.7 1.2e-43 148.8 0.7 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC45834.1 - 1e-16 60.9 0.0 1.3e-12 47.7 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC45834.1 - 8.5e-10 38.8 0.3 1.5e-05 25.2 0.1 2.7 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EFC45834.1 - 4.3e-07 30.2 0.0 0.0042 17.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 EFC45834.1 - 0.011 16.0 0.0 0.063 13.6 0.0 2.3 2 0 0 2 2 2 0 PAS fold PAS_8 PF13188.7 EFC45834.1 - 0.11 12.6 0.0 1.1 9.4 0.0 2.5 3 0 0 3 3 3 0 PAS domain AMP-binding PF00501.28 EFC45835.1 - 1.4e-99 333.5 0.0 1.8e-99 333.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF484 PF04340.12 EFC45835.1 - 0.14 11.9 0.0 0.33 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF484 EGF_2 PF07974.13 EFC45836.1 - 7.1e-11 42.3 92.5 0.0072 16.7 9.2 7.8 6 2 1 8 8 8 6 EGF-like domain DUF3599 PF12206.8 EFC45836.1 - 0.027 14.9 0.1 0.027 14.9 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3599) DUF2715 PF10895.8 EFC45836.1 - 0.13 11.9 0.0 0.29 10.7 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2715) F-box PF00646.33 EFC45837.1 - 0.0024 17.7 0.0 0.0043 16.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC45837.1 - 0.075 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like UPF0020 PF01170.18 EFC45838.1 - 0.013 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Pkinase PF00069.25 EFC45839.1 - 5.4e-77 258.7 0.0 6.1e-77 258.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45839.1 - 8.6e-42 143.2 0.0 1e-41 143.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC45839.1 - 2.9e-05 23.5 0.0 3.5e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFC45839.1 - 0.00063 18.8 0.2 0.00086 18.4 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC45839.1 - 0.0048 16.9 0.3 0.16 11.8 0.1 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC45839.1 - 0.015 14.7 0.2 0.025 13.9 0.2 1.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acetyltransf_1 PF00583.25 EFC45840.1 - 4.8e-12 46.1 0.0 6.2e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC45840.1 - 2.4e-08 34.0 0.3 2.9e-08 33.7 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC45840.1 - 2.8e-07 30.4 0.0 4.2e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 EFC45840.1 - 3.4e-06 27.4 0.0 4.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC45840.1 - 0.0019 18.3 0.1 0.0024 18.0 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC45840.1 - 0.035 14.3 0.2 0.046 13.9 0.2 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC45840.1 - 0.036 13.5 3.1 0.026 14.0 1.8 1.4 1 1 1 2 2 2 0 Putative acetyl-transferase Ras PF00071.22 EFC45841.1 - 2.9e-44 150.5 0.0 3.9e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45841.1 - 5.4e-28 97.6 0.0 1.1e-27 96.6 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45841.1 - 1.4e-10 40.9 0.0 2e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC45841.1 - 0.00021 21.3 0.0 0.00048 20.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC45841.1 - 0.005 16.3 0.1 0.011 15.2 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC45841.1 - 0.016 14.5 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Exo_endo_phos_2 PF14529.6 EFC45841.1 - 0.03 14.2 0.1 0.12 12.2 0.1 2.0 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase TniB PF05621.11 EFC45841.1 - 0.038 13.4 0.0 0.065 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EFC45841.1 - 0.039 13.7 0.0 1.9 8.2 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 EFC45841.1 - 0.057 13.4 0.0 0.15 12.1 0.0 1.7 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Cofilin_ADF PF00241.20 EFC45842.1 - 1.8e-23 82.6 0.3 2.1e-23 82.4 0.3 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein OTU PF02338.19 EFC45843.1 - 5.8e-09 36.5 0.1 8.8e-09 35.9 0.1 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease PEX11 PF05648.14 EFC45845.1 - 8.3e-14 51.6 0.1 1.2e-13 51.1 0.1 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sec20 PF03908.13 EFC45845.1 - 0.032 14.1 3.5 0.88 9.5 0.1 2.2 1 1 1 2 2 2 0 Sec20 EGF_2 PF07974.13 EFC45846.1 - 2.4e-31 107.8 456.3 0.00018 21.8 8.2 28.7 28 1 1 29 29 29 21 EGF-like domain REJ PF02010.15 EFC45846.1 - 1.5e-16 60.3 28.0 5.2e-14 51.9 20.9 2.5 1 1 0 2 2 2 2 REJ domain SSTK-IP PF15836.5 EFC45846.1 - 0.12 12.5 1.9 2 8.6 0.3 2.6 2 0 0 2 2 2 0 SSTK-interacting protein, TSSK6-activating co-chaperone protein Ribosomal_L31 PF01197.18 EFC45846.1 - 1.9 8.8 4.2 13 6.1 0.8 3.2 2 0 0 2 2 2 0 Ribosomal protein L31 REJ PF02010.15 EFC45847.1 - 6.2e-39 134.0 28.3 2.4e-36 125.5 7.1 4.1 2 1 2 4 4 4 3 REJ domain EGF_2 PF07974.13 EFC45847.1 - 1.8e-17 63.4 235.3 8e-05 22.9 8.5 15.6 15 2 1 16 16 16 10 EGF-like domain EGF_2 PF07974.13 EFC45848.1 - 1.6e-31 108.4 388.3 0.0003 21.1 8.4 20.7 20 1 1 21 21 21 20 EGF-like domain EGF_Tenascin PF18720.1 EFC45848.1 - 1.9e-06 27.8 229.7 0.043 13.9 3.2 20.4 20 0 0 20 20 20 15 Tenascin EGF domain EB PF01683.18 EFC45848.1 - 1.3e-05 25.4 287.3 0.59 10.5 5.3 21.4 10 6 9 20 20 20 17 EB module FHA PF00498.26 EFC45848.1 - 1.7 9.0 27.8 26 5.3 0.0 13.7 19 4 1 20 20 20 0 FHA domain Actin PF00022.19 EFC45849.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin Actin PF00022.19 EFC45850.1 - 4.1e-86 289.1 0.0 1e-43 149.5 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFC45850.1 - 0.0061 15.4 0.0 1.1 8.0 0.0 2.3 2 1 0 2 2 2 2 MreB/Mbl protein PPC PF04151.15 EFC45852.1 - 0.027 15.5 0.6 0.36 12.0 0.6 2.8 1 1 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain VraX PF17412.2 EFC45852.1 - 0.091 12.4 0.2 0.86 9.3 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function RWP-RK PF02042.15 EFC45853.1 - 2.4e-12 46.6 0.2 4.9e-12 45.6 0.2 1.6 1 0 0 1 1 1 1 RWP-RK domain NADH-u_ox-rdase PF10785.9 EFC45854.1 - 1e-07 32.5 0.0 1.6e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NIF PF03031.18 EFC45855.1 - 1.1e-17 64.3 0.3 2.3e-17 63.2 0.3 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase zf-RING_2 PF13639.6 EFC45856.1 - 1.3e-10 41.5 12.4 1.3e-10 41.5 12.4 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 EFC45856.1 - 2.1e-06 27.4 6.2 2.1e-06 27.4 6.2 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFC45856.1 - 2.5e-06 27.2 11.5 2.5e-06 27.2 11.5 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC45856.1 - 3.4e-06 26.8 9.9 3.4e-06 26.8 9.9 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 EFC45856.1 - 3.7e-06 27.1 13.2 3.7e-06 27.1 13.2 2.2 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 EFC45856.1 - 8.6e-05 22.3 11.3 0.00011 22.0 8.5 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) NRBF2 PF08961.10 EFC45856.1 - 0.00014 21.5 5.6 0.00033 20.3 5.6 1.6 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator zf-RING_5 PF14634.6 EFC45856.1 - 0.00017 21.5 10.8 0.00017 21.5 10.8 2.2 2 0 0 2 2 2 1 zinc-RING finger domain YabA PF06156.13 EFC45856.1 - 0.00022 21.8 1.1 0.00022 21.8 1.1 2.4 3 1 0 3 3 1 1 Initiation control protein YabA Zn_ribbon_17 PF17120.5 EFC45856.1 - 0.00031 20.3 9.5 0.00066 19.2 9.5 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 EFC45856.1 - 0.0014 18.6 5.3 0.0036 17.3 5.3 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 EFC45856.1 - 0.0027 17.7 9.1 0.0027 17.7 9.1 2.2 2 0 0 2 2 1 1 RING-type zinc-finger LCD1 PF09798.9 EFC45856.1 - 0.0055 15.3 3.5 0.008 14.8 3.5 1.3 1 0 0 1 1 1 1 DNA damage checkpoint protein ZapB PF06005.12 EFC45856.1 - 0.0087 16.5 10.1 0.0087 16.5 10.1 3.1 4 0 0 4 4 2 1 Cell division protein ZapB DivIC PF04977.15 EFC45856.1 - 0.014 15.2 6.0 0.014 15.2 6.0 2.4 3 0 0 3 3 2 0 Septum formation initiator bZIP_1 PF00170.21 EFC45856.1 - 0.026 14.6 10.9 0.072 13.2 10.9 1.8 1 0 0 1 1 1 0 bZIP transcription factor Prok-RING_4 PF14447.6 EFC45856.1 - 0.11 12.3 16.7 0.061 13.2 4.8 2.8 2 1 1 3 3 2 0 Prokaryotic RING finger family 4 eIF-4B PF06273.11 EFC45856.1 - 0.14 11.1 2.4 0.22 10.5 2.4 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B zf-RING_6 PF14835.6 EFC45856.1 - 0.17 11.8 4.6 0.66 9.9 4.6 1.9 1 1 0 1 1 1 0 zf-RING of BARD1-type protein zinc_ribbon_16 PF17034.5 EFC45856.1 - 0.34 11.1 9.0 0.076 13.2 4.7 2.2 2 0 0 2 2 1 0 Zinc-ribbon like family TSC22 PF01166.18 EFC45856.1 - 0.52 10.7 9.7 0.049 13.9 4.4 2.1 2 0 0 2 2 1 0 TSC-22/dip/bun family GrpE PF01025.19 EFC45856.1 - 0.99 9.1 10.6 0.31 10.7 7.1 2.0 2 0 0 2 2 1 0 GrpE zf-C3HC4_4 PF15227.6 EFC45856.1 - 6.2 7.1 11.8 5.2 7.3 8.2 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Peptidase_C1 PF00112.23 EFC45858.1 - 9e-41 140.3 6.6 3.3e-38 132.0 2.3 2.1 1 1 1 2 2 2 2 Papain family cysteine protease Propeptide_C1 PF08127.13 EFC45858.1 - 1.3e-05 24.9 0.0 2.7e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C1 propeptide Peptidase_C50 PF03568.17 EFC45861.1 - 5.6e-12 45.5 2.3 5.6e-12 45.5 2.3 2.9 5 0 0 5 5 5 1 Peptidase family C50 TPR_2 PF07719.17 EFC45861.1 - 0.024 14.7 0.1 0.3 11.3 0.4 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC45861.1 - 0.048 13.5 0.5 0.23 11.4 0.5 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2150 PF09920.9 EFC45861.1 - 0.12 12.3 3.6 0.81 9.6 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2150) FTCD_C PF04961.12 EFC45861.1 - 0.42 10.4 1.8 0.9 9.3 0.2 2.3 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase Clat_adaptor_s PF01217.20 EFC45862.1 - 5.5e-49 165.8 2.1 6.4e-49 165.6 2.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain HUN PF08729.10 EFC45863.1 - 1.6e-10 40.8 8.1 1.6e-10 40.8 8.1 2.8 2 0 0 2 2 2 1 HPC2 and ubinuclein domain F420_oxidored PF03807.17 EFC45864.1 - 8.9e-20 71.1 0.5 1.6e-19 70.3 0.5 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 EFC45864.1 - 6.3e-08 32.9 0.0 1.4e-07 31.8 0.0 1.6 2 0 0 2 2 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 EFC45864.1 - 1.2e-07 31.2 0.1 2.8e-07 30.1 0.1 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 EFC45864.1 - 0.00024 20.7 0.1 0.00037 20.1 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EFC45864.1 - 0.00026 21.1 0.1 0.00057 20.0 0.1 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 EFC45864.1 - 0.0011 18.9 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 EFC45864.1 - 0.0021 18.0 1.3 0.0073 16.3 0.4 2.0 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 EFC45864.1 - 0.0068 16.3 0.4 0.021 14.7 0.5 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 EFC45864.1 - 0.0075 15.9 1.5 0.02 14.6 1.5 1.8 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 EFC45864.1 - 0.0081 16.4 0.6 0.018 15.3 0.3 1.8 2 0 0 2 2 2 1 TrkA-N domain Pyr_redox PF00070.27 EFC45864.1 - 0.011 16.2 0.8 0.028 15.0 0.4 1.9 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase adh_short PF00106.25 EFC45864.1 - 0.03 13.8 0.2 0.091 12.2 0.1 1.8 2 0 0 2 2 2 0 short chain dehydrogenase NAD_binding_10 PF13460.6 EFC45864.1 - 0.036 14.0 0.2 0.079 12.8 0.2 1.6 1 0 0 1 1 1 0 NAD(P)H-binding XdhC_C PF13478.6 EFC45864.1 - 0.06 13.8 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 XdhC Rossmann domain GFO_IDH_MocA PF01408.22 EFC45864.1 - 0.065 14.1 0.0 0.11 13.4 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 EFC45864.1 - 0.071 13.4 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 EFC45864.1 - 0.076 12.2 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_transf_4 PF13439.6 EFC45864.1 - 0.14 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 ThiF PF00899.21 EFC45864.1 - 0.15 11.4 0.4 0.29 10.5 0.4 1.4 1 0 0 1 1 1 0 ThiF family RICTOR_M PF14666.6 EFC45866.1 - 0.091 12.5 0.9 0.2 11.4 0.3 2.0 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain Ribosomal_L22 PF00237.19 EFC45867.1 - 5e-16 58.8 0.6 9.2e-16 58.0 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e DUF3289 PF11692.8 EFC45867.1 - 0.046 13.3 0.1 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3289) SHOCT PF09851.9 EFC45868.1 - 0.19 11.5 4.4 0.34 10.7 4.4 1.5 1 0 0 1 1 1 0 Short C-terminal domain Acyltransferase PF01553.21 EFC45869.1 - 1e-21 77.0 0.0 2.3e-21 75.8 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase DAGAT PF03982.13 EFC45869.1 - 0.031 13.2 0.0 1.1 8.1 0.0 2.4 1 1 1 2 2 2 0 Diacylglycerol acyltransferase IRS PF02174.17 EFC45869.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 PTB domain (IRS-1 type) 5-FTHF_cyc-lig PF01812.20 EFC45869.1 - 4.2 7.2 6.6 4.2 7.2 5.3 1.7 1 1 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family RNase_T PF00929.24 EFC45870.1 - 1.2e-20 74.7 0.0 2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 EFC45870.1 - 5.6e-05 22.9 0.0 0.00018 21.3 0.0 1.8 1 1 0 1 1 1 1 3'-5' exonuclease DNApol_Exo PF18136.1 EFC45870.1 - 0.011 14.9 0.0 0.031 13.4 0.0 1.8 1 1 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain CAF1 PF04857.20 EFC45870.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease EI24 PF07264.11 EFC45871.1 - 0.0032 17.7 0.6 0.0044 17.3 0.6 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Imm58 PF15581.6 EFC45871.1 - 0.16 12.1 0.1 0.16 12.1 0.1 1.8 2 0 0 2 2 2 0 Immunity protein 58 Glyco_hydro_19 PF00182.19 EFC45872.1 - 6.1e-15 55.7 0.8 2.3e-14 53.9 0.2 2.2 1 1 1 2 2 2 1 Chitinase class I SH3_3 PF08239.11 EFC45872.1 - 1.7e-07 31.4 0.0 5.7e-07 29.7 0.0 2.0 2 0 0 2 2 2 1 Bacterial SH3 domain DUF2048 PF09752.9 EFC45874.1 - 0.0049 16.0 0.4 6.6 5.7 0.0 3.2 3 0 0 3 3 3 3 Abhydrolase domain containing 18 Peptidase_M16_C PF05193.21 EFC45875.1 - 1.1e-17 64.6 0.0 7.4e-17 61.9 0.0 2.2 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFC45875.1 - 1.8e-13 50.7 0.0 3.8e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Pkinase PF00069.25 EFC45876.1 - 5.1e-40 137.5 0.0 9e-40 136.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45876.1 - 9.8e-29 100.4 0.0 1.7e-28 99.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RCC1 PF00415.18 EFC45876.1 - 9.9e-24 83.7 1.5 7.5e-08 32.9 0.1 5.6 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC45876.1 - 1.7e-15 56.4 7.0 1.4e-07 31.2 0.0 5.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat AAA PF00004.29 EFC45877.1 - 3.1e-17 63.2 0.1 1.2e-16 61.3 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC45877.1 - 0.00026 21.4 0.1 0.0035 17.7 0.1 2.7 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 EFC45877.1 - 0.001 18.3 0.0 0.0037 16.5 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 EFC45877.1 - 0.005 17.0 0.4 0.022 14.9 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 EFC45877.1 - 0.0063 16.0 0.0 0.017 14.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region IQ PF00612.27 EFC45877.1 - 0.0069 16.1 0.2 0.0069 16.1 0.2 2.5 2 0 0 2 2 2 1 IQ calmodulin-binding motif AAA_25 PF13481.6 EFC45877.1 - 0.0077 15.8 1.2 2.7 7.5 0.0 2.9 2 1 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 EFC45877.1 - 0.012 16.0 0.0 0.038 14.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase RuvB_N PF05496.12 EFC45877.1 - 0.025 14.3 0.0 0.072 12.8 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC45877.1 - 0.077 13.0 0.0 0.36 10.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 EFC45877.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFC45877.1 - 0.13 12.2 0.1 0.39 10.6 0.0 1.8 1 1 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 EFC45877.1 - 0.18 11.7 0.6 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Apyrase PF06079.11 EFC45878.1 - 8e-115 383.1 2.4 9.9e-115 382.8 2.4 1.1 1 0 0 1 1 1 1 Apyrase CcmE PF03100.15 EFC45878.1 - 0.14 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 CcmE V-ATPase_C PF03223.15 EFC45879.1 - 9.2e-92 308.3 9.4 1.1e-91 308.1 9.4 1.0 1 0 0 1 1 1 1 V-ATPase subunit C XPG_I PF00867.18 EFC45879.1 - 0.16 12.3 1.0 1.3 9.4 0.3 2.5 2 0 0 2 2 2 0 XPG I-region TMF_DNA_bd PF12329.8 EFC45880.1 - 0.72 9.9 8.2 0.44 10.6 3.7 2.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding eIF3g PF12353.8 EFC45882.1 - 2.6e-15 56.9 6.1 2.6e-15 56.9 6.1 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 EFC45882.1 - 6.5e-14 51.5 0.0 1.3e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.23 EFC45884.1 - 1.4e-110 369.3 1.8 1.4e-110 369.3 1.8 4.9 3 2 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EFC45884.1 - 6.5e-26 91.0 0.3 6.5e-26 91.0 0.3 6.3 4 1 0 4 4 4 1 Microtubule binding Cep57_CLD_2 PF14197.6 EFC45884.1 - 0.0033 17.5 11.9 0.0033 17.5 11.9 16.1 5 4 7 12 12 12 2 Centrosome localisation domain of PPC89 AAA_22 PF13401.6 EFC45884.1 - 0.82 9.9 0.0 0.82 9.9 0.0 5.7 6 2 0 7 7 7 0 AAA domain Filament PF00038.21 EFC45884.1 - 3.6 7.1 209.7 0.03 13.9 36.3 6.8 2 1 4 6 6 6 0 Intermediate filament protein SET PF00856.28 EFC45885.1 - 2.2e-10 41.2 0.1 2.2e-10 41.2 0.1 3.1 3 1 0 3 3 3 1 SET domain Peptidase_S9_N PF02897.15 EFC45886.1 - 5.8e-77 259.2 5.0 1e-76 258.4 5.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 EFC45886.1 - 1.1e-62 211.3 0.1 1.7e-62 210.7 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFC45886.1 - 0.047 13.0 0.0 0.097 11.9 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Esterase PF00756.20 EFC45886.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase FEZ PF07763.13 EFC45887.1 - 0.0057 16.4 1.3 0.0069 16.2 1.3 1.1 1 0 0 1 1 1 1 FEZ-like protein Peptidase_M22 PF00814.25 EFC45888.1 - 5.9e-87 291.8 0.0 7.1e-87 291.5 0.0 1.1 1 0 0 1 1 1 1 Glycoprotease family BcrAD_BadFG PF01869.20 EFC45888.1 - 0.0059 16.1 0.0 0.028 13.9 0.0 1.9 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Carbam_trans_N PF02543.15 EFC45888.1 - 0.033 13.9 0.0 0.66 9.6 0.0 2.1 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus Filo_VP35 PF02097.15 EFC45888.1 - 0.12 11.5 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Filoviridae VP35 TPT PF03151.16 EFC45889.1 - 6.1e-20 71.7 22.2 7.4e-20 71.5 22.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC45889.1 - 7.2e-08 32.7 12.3 7.2e-08 32.7 12.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family ANAPC4_WD40 PF12894.7 EFC45890.1 - 9.9e-11 41.8 10.1 0.013 15.8 0.0 7.9 6 2 4 10 10 9 2 Anaphase-promoting complex subunit 4 WD40 domain Clathrin PF00637.20 EFC45890.1 - 1.3e-08 34.8 2.8 1.5e-05 24.9 0.0 3.9 2 1 2 4 4 4 2 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 EFC45890.1 - 1e-07 31.4 6.0 0.00035 19.7 0.0 5.2 4 1 2 6 6 6 2 Coatomer WD associated region TPR_7 PF13176.6 EFC45890.1 - 3.8e-06 26.6 1.6 0.9 9.7 0.1 5.0 4 1 0 4 4 4 2 Tetratricopeptide repeat WD40 PF00400.32 EFC45890.1 - 1.6e-05 25.6 3.1 31 5.6 0.0 6.6 7 0 0 7 7 5 0 WD domain, G-beta repeat TPR_11 PF13414.6 EFC45890.1 - 0.0009 18.9 0.5 1.4 8.6 0.0 4.4 3 1 1 4 4 4 1 TPR repeat TPR_14 PF13428.6 EFC45890.1 - 0.0011 19.6 4.4 6.1 7.9 0.0 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC45890.1 - 0.0014 18.8 0.4 0.012 15.9 0.3 2.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 eIF2A PF08662.11 EFC45890.1 - 0.0023 17.8 8.4 0.019 14.9 0.8 4.2 5 0 0 5 5 5 1 Eukaryotic translation initiation factor eIF2A RPN1_RPN2_N PF17781.1 EFC45890.1 - 0.0071 15.8 0.1 0.018 14.4 0.1 1.6 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain TPR_1 PF00515.28 EFC45890.1 - 0.0095 15.7 3.0 15 5.6 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC45890.1 - 0.01 16.1 2.0 7 7.0 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TackOD1 PF18551.1 EFC45890.1 - 0.06 13.0 10.1 0.023 14.4 7.1 1.8 2 0 0 2 2 1 0 Thaumarchaeal output domain 1 Pep3_Vps18 PF05131.14 EFC45890.1 - 0.072 12.9 1.8 13 5.6 0.0 3.0 3 0 0 3 3 3 0 Pep3/Vps18/deep orange family TPR_16 PF13432.6 EFC45890.1 - 0.096 13.3 0.1 21 5.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ste5_C PF12194.8 EFC45890.1 - 0.13 12.2 3.4 0.62 10.0 0.6 3.1 3 0 0 3 3 3 0 Protein kinase Fus3-binding TPR_2 PF07719.17 EFC45890.1 - 0.22 11.7 8.8 14 6.1 0.1 5.5 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC45890.1 - 1.1 9.7 3.9 20 5.7 0.1 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat FYVE_2 PF02318.16 EFC45890.1 - 2.8 8.2 7.6 3 8.1 4.2 2.8 3 0 0 3 3 3 0 FYVE-type zinc finger tRNA-synt_2 PF00152.20 EFC45891.1 - 2.7e-90 302.6 0.9 3.7e-90 302.2 0.1 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFC45891.1 - 9.5e-11 41.5 0.0 1.8e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Tropomyosin PF00261.20 EFC45891.1 - 0.0024 17.3 5.3 0.0024 17.3 5.3 1.8 2 0 0 2 2 2 1 Tropomyosin DUF4482 PF14818.6 EFC45891.1 - 0.028 15.3 6.8 0.07 14.0 6.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) TERB2 PF15101.6 EFC45891.1 - 0.045 13.8 0.3 0.091 12.8 0.3 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF1664 PF07889.12 EFC45891.1 - 0.42 10.7 6.8 0.18 11.9 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) LMBR1 PF04791.16 EFC45891.1 - 2.3 7.0 4.0 3.2 6.5 4.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_M41 PF01434.18 EFC45893.1 - 2.2e-63 213.5 0.0 3.9e-63 212.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 EFC45893.1 - 4.1e-40 137.3 0.0 1.1e-39 135.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC45893.1 - 8.3e-15 54.3 0.2 2.3e-14 52.9 0.0 1.9 2 0 0 2 2 1 1 AAA+ lid domain RuvB_N PF05496.12 EFC45893.1 - 0.00022 21.0 0.0 0.00061 19.6 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC45893.1 - 0.00065 20.0 0.2 0.083 13.2 0.0 3.2 2 1 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EFC45893.1 - 0.0014 18.6 0.4 0.0044 17.0 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 EFC45893.1 - 0.0019 17.5 0.0 0.0037 16.5 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 EFC45893.1 - 0.0028 17.8 0.0 0.012 15.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 EFC45893.1 - 0.0074 16.7 0.0 0.092 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 EFC45893.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFC45893.1 - 0.02 14.6 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_17 PF13207.6 EFC45893.1 - 0.022 15.2 0.0 0.12 12.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFC45893.1 - 0.033 13.6 0.3 0.084 12.2 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFC45893.1 - 0.042 14.4 0.1 0.22 12.1 0.1 2.3 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 EFC45893.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 EFC45893.1 - 0.13 11.7 0.2 0.48 9.8 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 EFC45893.1 - 0.15 11.7 0.1 0.91 9.2 0.1 2.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFC45893.1 - 0.15 12.5 0.1 0.83 10.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter TcdA_TcdB PF12919.7 EFC45894.1 - 0.088 12.1 2.1 0.7 9.1 1.7 2.1 1 1 1 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain DUF5300 PF17224.3 EFC45894.1 - 0.11 12.8 0.5 0.28 11.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) Peptidase_S10 PF00450.22 EFC45895.1 - 7e-117 391.4 1.3 8.1e-117 391.2 1.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase PPR PF01535.20 EFC45897.1 - 4.5e-25 86.1 14.1 0.0036 17.4 0.1 9.6 9 0 0 9 9 9 6 PPR repeat PPR_2 PF13041.6 EFC45897.1 - 6.8e-24 83.8 18.3 5.7e-08 32.8 0.5 7.8 7 1 1 8 8 8 5 PPR repeat family PPR_1 PF12854.7 EFC45897.1 - 5.9e-08 32.3 0.0 0.42 10.3 0.0 6.2 7 0 0 7 7 7 2 PPR repeat PPR_3 PF13812.6 EFC45897.1 - 5.8e-05 23.1 13.3 13 6.0 0.0 7.2 4 1 4 8 8 8 2 Pentatricopeptide repeat domain TPR_19 PF14559.6 EFC45897.1 - 0.012 16.1 0.0 0.21 12.2 0.0 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC45897.1 - 0.061 14.0 0.4 35 5.3 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ATP13 PF12921.7 EFC45897.1 - 0.081 12.8 0.2 1.7 8.5 0.0 3.2 3 0 0 3 3 3 0 Mitochondrial ATPase expression TPR_8 PF13181.6 EFC45897.1 - 4 7.9 7.5 44 4.6 0.3 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Serpin PF00079.20 EFC45898.1 - 2.4e-76 257.5 8.2 3e-76 257.2 8.2 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SH3_6 PF12913.7 EFC45898.1 - 0.12 12.0 0.1 0.29 10.7 0.1 1.6 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) Kinesin PF00225.23 EFC45899.1 - 3.3e-99 332.0 2.8 9.6e-99 330.4 2.8 1.9 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC45899.1 - 2.1e-37 128.3 0.2 2.1e-37 128.3 0.2 3.0 4 0 0 4 4 4 1 Microtubule binding HUN PF08729.10 EFC45899.1 - 0.0067 16.4 0.4 0.027 14.5 0.4 2.0 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Imm59 PF15597.6 EFC45899.1 - 0.32 11.5 3.9 0.23 11.9 0.3 2.6 2 0 0 2 2 2 0 Immunity protein 59 Form_Nir_trans PF01226.17 EFC45900.1 - 2.9e-61 206.8 11.0 3.3e-61 206.6 11.0 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter HKR_ArcB_TM PF18415.1 EFC45900.1 - 0.063 14.1 0.1 0.17 12.7 0.1 1.8 1 0 0 1 1 1 0 Histidine kinase receptor ArcB trans-membrane domain DUF5353 PF17304.2 EFC45900.1 - 0.067 12.9 2.5 0.46 10.3 0.4 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5353) Chordopox_A13L PF05961.11 EFC45900.1 - 0.083 13.1 0.5 3 8.1 0.0 2.6 3 0 0 3 3 3 0 Chordopoxvirus A13L protein DUF4131 PF13567.6 EFC45900.1 - 0.13 11.9 0.6 1.1 8.9 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) Ras PF00071.22 EFC45902.1 - 3.6e-24 85.2 0.0 2.9e-12 46.5 0.0 3.6 2 1 1 3 3 3 3 Ras family Roc PF08477.13 EFC45902.1 - 1.2e-06 28.8 0.1 9.9e-06 25.8 0.0 2.3 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC45902.1 - 0.0087 16.1 0.1 0.021 14.9 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2515 PF10720.9 EFC45902.1 - 0.021 14.0 0.1 0.046 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2515) Arf PF00025.21 EFC45902.1 - 0.036 13.5 0.2 0.1 12.0 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family Glucosamine_iso PF01182.20 EFC45902.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase IMPa_helical PF18642.1 EFC45902.1 - 0.26 11.7 2.2 0.47 10.9 0.3 2.4 3 0 0 3 3 3 0 Immunomodulating metalloprotease helical domain A_deaminase PF00962.22 EFC45903.1 - 2.8e-118 395.0 0.0 4.9e-118 394.2 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase Peptidase_M24 PF00557.24 EFC45904.1 - 1.2e-44 152.5 0.0 1.6e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Vasohibin PF14822.6 EFC45905.1 - 3e-51 174.0 0.5 6.5e-51 172.9 0.5 1.5 1 0 0 1 1 1 1 Vasohibin FYVE PF01363.21 EFC45905.1 - 5e-17 61.8 14.5 1.5e-16 60.3 14.5 1.8 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 EFC45905.1 - 0.013 15.8 8.1 0.039 14.2 8.1 1.8 1 0 0 1 1 1 0 FYVE-type zinc finger Guanylate_cyc PF00211.20 EFC45906.1 - 4.4e-29 101.4 0.1 1.1e-28 100.2 0.1 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AI-2E_transport PF01594.16 EFC45906.1 - 0.012 14.8 1.5 0.1 11.7 0.2 2.2 2 0 0 2 2 2 0 AI-2E family transporter Baculo_11_kDa PF06143.11 EFC45906.1 - 0.7 9.5 5.4 2.7 7.6 1.1 2.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family Glyco_hydro_31 PF01055.26 EFC45907.1 - 3.3e-144 481.3 4.6 4.6e-144 480.9 4.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 EFC45907.1 - 3.6e-23 81.9 0.0 9e-23 80.7 0.0 1.7 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 EFC45907.1 - 1.4e-14 54.2 2.2 3.6e-14 52.8 1.1 2.4 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 EFC45907.1 - 0.00032 20.9 1.4 0.0012 19.1 0.1 2.5 2 1 1 3 3 3 1 Domain of unknown function (DUF5110) TPR_2 PF07719.17 EFC45908.1 - 0.15 12.3 0.1 0.45 10.7 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat SOBP PF15279.6 EFC45909.1 - 1.4 9.5 13.7 0.3 11.7 9.1 2.1 3 0 0 3 3 3 0 Sine oculis-binding protein ADH_zinc_N_2 PF13602.6 EFC45910.1 - 2.6e-11 44.7 0.0 4.5e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 EFC45910.1 - 1e-06 28.6 0.0 1.1e-05 25.2 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC45910.1 - 0.0027 17.7 0.0 0.0051 16.8 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Tobravirus_2B PF05271.11 EFC45910.1 - 0.057 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Tobravirus 2B protein G-alpha PF00503.20 EFC45911.1 - 3.4e-31 108.7 8.0 4.4e-31 108.3 8.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC45911.1 - 0.084 12.3 0.9 0.18 11.2 0.4 1.7 1 1 1 2 2 2 0 ADP-ribosylation factor family Glyco_transf_25 PF01755.17 EFC45912.1 - 0.0013 18.6 2.1 0.014 15.3 2.1 2.7 1 1 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) Glycos_transf_2 PF00535.26 EFC45912.1 - 0.0084 15.9 0.3 0.02 14.7 0.2 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 DUF1980 PF09323.10 EFC45912.1 - 0.39 10.6 8.9 1 9.2 6.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) YccF PF03733.13 EFC45913.1 - 0.0016 19.1 0.6 0.0024 18.6 0.6 1.2 1 0 0 1 1 1 1 Inner membrane component domain Pet100 PF09803.9 EFC45913.1 - 0.0074 16.8 2.2 0.027 15.0 2.2 2.0 1 1 0 1 1 1 1 Pet100 DUF908 PF06012.12 EFC45913.1 - 2.4 7.5 5.2 0.35 10.2 1.3 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Proteasome PF00227.26 EFC45914.1 - 3.8e-61 205.9 0.2 4.6e-61 205.6 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFC45914.1 - 2.3e-14 52.8 0.1 3.9e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Proteasome PF00227.26 EFC45915.1 - 5.3e-50 169.5 0.4 6.9e-50 169.2 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 EFC45915.1 - 1.3e-05 24.5 0.2 1.3e-05 24.5 0.2 1.9 2 0 0 2 2 2 1 Proteasome beta subunits C terminal PCI PF01399.27 EFC45916.1 - 1.6e-16 60.7 1.5 8.4e-16 58.4 0.0 2.8 3 1 0 3 3 3 1 PCI domain RPN5_C PF18098.1 EFC45916.1 - 3.6e-14 52.6 4.3 8.3e-14 51.4 4.3 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain SPOB_a PF14689.6 EFC45916.1 - 0.81 9.4 6.6 2 8.2 0.6 4.0 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain DUF5099 PF17025.5 EFC45917.1 - 0.65 10.4 7.6 0.12 12.8 1.4 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5099) Aldedh PF00171.22 EFC45919.1 - 1.8e-100 336.6 0.0 2.2e-100 336.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Relaxase PF03432.14 EFC45920.1 - 0.0023 17.6 1.5 0.0023 17.6 1.5 2.4 2 1 1 3 3 3 1 Relaxase/Mobilisation nuclease domain PBECR3 PF18812.1 EFC45921.1 - 0.19 11.7 3.3 0.63 10.0 3.3 1.9 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 MDM1 PF15501.6 EFC45922.1 - 0.025 13.8 22.7 0.03 13.5 22.7 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Borrelia_P83 PF05262.11 EFC45922.1 - 0.026 13.0 18.9 0.027 13.0 18.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RR_TM4-6 PF06459.12 EFC45922.1 - 0.17 11.7 23.4 0.21 11.4 23.4 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4407 PF14362.6 EFC45922.1 - 0.36 10.1 9.8 0.43 9.9 9.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_11 PF13086.6 EFC45922.1 - 0.61 9.8 14.4 0.81 9.4 14.4 1.4 1 0 0 1 1 1 0 AAA domain HSP70 PF00012.20 EFC45922.1 - 0.75 7.9 11.1 0.81 7.8 11.1 1.2 1 0 0 1 1 1 0 Hsp70 protein Sec62 PF03839.16 EFC45922.1 - 0.97 8.9 22.7 1.4 8.3 22.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF913 PF06025.12 EFC45922.1 - 1.4 7.9 7.0 1.5 7.7 7.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Paramyxo_ncap PF00973.19 EFC45922.1 - 2 7.2 10.0 2.2 7.1 10.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein LMBR1 PF04791.16 EFC45922.1 - 2.1 7.1 12.1 2.6 6.9 12.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RPOL_N PF14700.6 EFC45922.1 - 2.4 7.5 18.6 1.8 7.9 16.3 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal NPR3 PF03666.13 EFC45922.1 - 5.2 5.8 21.9 8.7 5.0 21.9 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2126 PF09899.9 EFC45922.1 - 9.4 4.2 10.7 15 3.5 10.7 1.4 1 1 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) SID-1_RNA_chan PF13965.6 EFC45922.1 - 10 4.4 6.7 11 4.3 6.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Cupin_8 PF13621.6 EFC45923.1 - 3.3e-21 76.2 2.9 5.8e-21 75.4 2.9 1.3 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 EFC45923.1 - 6.1e-18 65.3 5.8 1.5e-10 41.5 0.1 3.6 3 1 1 4 4 4 2 JmjC domain, hydroxylase F-box-like PF12937.7 EFC45923.1 - 0.00023 21.0 0.1 0.00045 20.1 0.1 1.5 1 0 0 1 1 1 1 F-box-like Cupin_4 PF08007.12 EFC45923.1 - 0.0024 17.4 0.2 0.032 13.7 0.0 2.5 3 0 0 3 3 3 1 Cupin superfamily protein F-box PF00646.33 EFC45923.1 - 0.0035 17.2 0.3 0.0082 16.0 0.3 1.6 1 0 0 1 1 1 1 F-box domain Proteasome PF00227.26 EFC45924.1 - 1.3e-50 171.6 0.2 1.5e-50 171.3 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit PALP PF00291.25 EFC45925.1 - 1.3e-61 208.6 0.1 1.5e-61 208.4 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme bZIP_1 PF00170.21 EFC45925.1 - 0.047 13.8 1.1 0.1 12.7 1.1 1.6 1 0 0 1 1 1 0 bZIP transcription factor DivIC PF04977.15 EFC45925.1 - 0.1 12.4 0.7 0.27 11.0 0.7 1.7 1 0 0 1 1 1 0 Septum formation initiator DUF3879 PF12995.7 EFC45925.1 - 0.12 12.1 0.4 5.1 6.8 0.0 2.8 3 1 0 3 3 3 0 Domain of unknown function, E. rectale Gene description (DUF3879) Glucosamine_iso PF01182.20 EFC45925.1 - 0.15 11.9 0.0 6 6.7 0.0 2.2 2 0 0 2 2 2 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase ABC_tran_CTD PF16326.5 EFC45925.1 - 0.24 11.7 2.7 0.51 10.6 2.7 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain DUF4404 PF14357.6 EFC45926.1 - 4 8.2 6.1 25 5.6 0.2 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4404) WD40 PF00400.32 EFC45927.1 - 4.1e-15 55.9 4.3 0.016 16.1 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC45927.1 - 3.3e-08 33.7 0.0 0.0025 18.1 0.0 4.4 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 EFC45927.1 - 0.00025 19.7 0.9 0.0013 17.4 0.2 2.3 1 1 0 2 2 2 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 EFC45927.1 - 0.0081 16.6 2.0 34 5.1 0.0 4.1 4 0 0 4 4 4 0 PQQ-like domain DUF4394 PF14339.6 EFC45927.1 - 0.018 14.4 0.0 3 7.1 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4394) Nucleoporin2 PF04096.14 EFC45927.1 - 0.022 14.9 4.7 0.092 12.9 1.8 2.2 2 0 0 2 2 2 0 Nucleoporin autopeptidase MetallophosC PF16370.5 EFC45927.1 - 0.084 13.1 0.6 0.2 11.9 0.0 1.9 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase XPG_I PF00867.18 EFC45928.1 - 4.9e-26 90.9 0.0 2.2e-25 88.8 0.0 2.2 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 EFC45928.1 - 3.3e-23 82.1 0.1 2.6e-22 79.2 0.1 2.5 1 1 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 EFC45928.1 - 1.8e-07 30.9 0.0 5.1e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 XPG domain containing SlyX PF04102.12 EFC45929.1 - 1.1 9.9 4.2 1.1 9.9 0.5 2.4 2 0 0 2 2 2 0 SlyX LSM PF01423.22 EFC45930.1 - 8.7e-21 73.4 0.1 1e-20 73.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 EFC45930.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Hfq protein Swi3 PF07962.12 EFC45931.1 - 0.0058 16.6 0.1 0.012 15.6 0.1 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 SRP-alpha_N PF04086.13 EFC45931.1 - 0.081 12.8 22.8 0.11 12.3 13.2 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal Spem1 PF15670.5 EFC45931.1 - 0.37 10.3 12.6 0.05 13.2 8.3 1.7 2 0 0 2 2 2 0 Spermatid maturation protein 1 CDC27 PF09507.10 EFC45931.1 - 0.38 10.1 31.7 0.74 9.1 20.0 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 BUD22 PF09073.10 EFC45931.1 - 2.2 7.5 32.9 0.078 12.3 17.7 2.2 2 0 0 2 2 2 0 BUD22 BTB PF00651.31 EFC45932.1 - 1.4e-09 38.2 0.8 3.6e-09 36.8 0.1 2.0 2 0 0 2 2 2 1 BTB/POZ domain Bacillus_HBL PF05791.11 EFC45932.1 - 0.2 11.5 7.5 0.48 10.2 7.5 1.6 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) RRM_1 PF00076.22 EFC45933.1 - 1.9e-13 50.0 0.2 2.9e-13 49.4 0.2 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Presenilin PF01080.17 EFC45933.1 - 2.3 6.9 3.8 3.1 6.5 3.8 1.1 1 0 0 1 1 1 0 Presenilin DUF948 PF06103.11 EFC45934.1 - 0.04 14.2 1.3 2.6 8.4 0.2 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) UPF0147 PF03685.13 EFC45934.1 - 0.055 13.5 0.2 0.19 11.8 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) Use1 PF09753.9 EFC45934.1 - 0.1 12.3 0.3 0.1 12.3 0.3 2.7 4 0 0 4 4 4 0 Membrane fusion protein Use1 DHHC PF01529.20 EFC45934.1 - 0.77 9.9 20.7 0.37 10.9 9.7 2.7 1 1 2 3 3 3 0 DHHC palmitoyltransferase DPM3 PF08285.11 EFC45934.1 - 6.8 7.0 10.7 0.63 10.3 1.4 2.6 2 1 1 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LMF1 PF06762.14 EFC45934.1 - 8.1 5.4 14.8 1.6 7.7 1.3 2.0 1 1 1 2 2 2 0 Lipase maturation factor Wzy_C PF04932.15 EFC45934.1 - 8.9 5.9 14.8 3.6 7.2 4.5 2.4 1 1 1 2 2 2 0 O-Antigen ligase Abhydrolase_3 PF07859.13 EFC45935.1 - 3.5e-38 131.6 0.0 4.3e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFC45935.1 - 1.3e-13 50.7 0.1 5.2e-13 48.7 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Chlorophyllase2 PF12740.7 EFC45935.1 - 4e-06 25.9 0.0 6.2e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EFC45935.1 - 0.00064 18.8 0.0 0.0009 18.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Say1_Mug180 PF10340.9 EFC45935.1 - 0.0011 17.9 0.7 0.0016 17.3 0.7 1.3 1 1 0 1 1 1 1 Steryl acetyl hydrolase PAF-AH_p_II PF03403.13 EFC45935.1 - 0.081 11.4 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Sdh_cyt PF01127.22 EFC45936.1 - 0.054 13.5 0.7 0.054 13.5 0.7 3.0 2 1 1 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit SPC25 PF06703.11 EFC45936.1 - 0.099 12.4 10.2 0.18 11.6 4.5 2.3 1 1 1 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Renin_r PF07850.14 EFC45936.1 - 1.3 9.7 0.0 1.3 9.7 0.0 4.0 1 1 4 5 5 5 0 Renin receptor-like protein FA_desaturase PF00487.24 EFC45937.1 - 1.9e-23 83.6 9.0 3.6e-23 82.7 9.0 1.4 1 1 0 1 1 1 1 Fatty acid desaturase LRR_6 PF13516.6 EFC45940.1 - 7.4e-13 47.4 34.6 7.3e-05 22.5 0.0 12.1 13 0 0 13 13 13 4 Leucine Rich repeat LRR_4 PF12799.7 EFC45940.1 - 1.5e-11 44.3 36.6 0.012 16.1 2.7 9.0 2 1 7 10 10 10 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45940.1 - 1.5e-11 43.8 33.0 0.00022 20.9 5.5 8.1 5 3 2 7 7 7 6 Leucine rich repeat F-box-like PF12937.7 EFC45940.1 - 5.5e-06 26.2 0.3 1.2e-05 25.1 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC45940.1 - 0.00014 21.7 0.2 0.0004 20.2 0.2 1.8 1 0 0 1 1 1 1 F-box domain LRR_1 PF00560.33 EFC45940.1 - 0.00042 20.5 22.2 8.7 7.3 0.1 10.2 12 1 0 12 12 12 1 Leucine Rich Repeat EF-hand_10 PF14788.6 EFC45940.1 - 0.041 13.7 0.1 0.2 11.5 0.0 2.1 2 0 0 2 2 2 0 EF hand EF1G PF00647.19 EFC45941.1 - 0.012 15.7 1.3 1 9.4 0.1 2.7 1 1 1 2 2 2 0 Elongation factor 1 gamma, conserved domain GPHR_N PF12537.8 EFC45941.1 - 0.15 12.2 0.2 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal DUF3584 PF12128.8 EFC45942.1 - 0.00033 18.4 39.7 0.00047 17.8 39.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Apolipoprotein PF01442.18 EFC45942.1 - 0.0015 18.4 25.0 0.0015 18.4 25.0 2.5 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 EFC45942.1 - 0.034 14.2 23.8 1.2 9.2 4.5 4.0 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus TarH PF02203.15 EFC45942.1 - 0.057 13.3 3.6 0.19 11.6 0.1 2.7 2 1 0 2 2 2 0 Tar ligand binding domain homologue Osmo_CC PF08946.10 EFC45942.1 - 0.31 11.3 0.1 0.31 11.3 0.1 4.3 4 1 0 4 4 4 0 Osmosensory transporter coiled coil NPV_P10 PF05531.12 EFC45942.1 - 0.42 11.1 24.3 0.61 10.6 0.5 4.9 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4304 PF14137.6 EFC45942.1 - 0.63 10.2 10.2 1.9 8.6 9.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4304) SUV3_C PF12513.8 EFC45942.1 - 0.83 9.6 3.2 11 6.1 0.4 3.1 2 0 0 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal Terminase_6C PF17289.2 EFC45942.1 - 5.4 7.1 6.3 2.1 8.4 1.1 2.6 1 1 3 4 4 4 0 Terminase RNaseH-like domain Radical_SAM PF04055.21 EFC45943.1 - 1.5e-16 61.2 0.1 5.4e-16 59.4 0.0 1.8 1 1 1 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 EFC45943.1 - 4.5e-09 36.7 0.0 1.2e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 EFC45943.1 - 2.6e-08 34.0 0.0 8.6e-08 32.3 0.0 1.9 1 0 0 1 1 1 1 4Fe-4S single cluster domain DUF3365 PF11845.8 EFC45943.1 - 0.055 13.8 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) ABC2_membrane PF01061.24 EFC45944.1 - 5.2e-13 48.9 18.7 5.2e-13 48.9 18.7 1.8 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 EFC45944.1 - 0.053 12.6 34.1 0.13 11.3 34.0 1.8 1 1 0 1 1 1 0 ABC-2 family transporter protein DUF373 PF04123.13 EFC45944.1 - 2 7.8 10.3 3.9 6.8 9.8 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF373) TANGO2 PF05742.12 EFC45947.1 - 1.1e-25 91.1 6.8 5.6e-25 88.8 6.8 2.0 1 1 0 1 1 1 1 Transport and Golgi organisation 2 RNase_E_G PF10150.9 EFC45947.1 - 0.13 11.7 4.6 0.057 12.8 1.7 1.8 2 0 0 2 2 2 0 Ribonuclease E/G family RRM_1 PF00076.22 EFC45948.1 - 1.9e-22 78.9 0.1 2.5e-22 78.5 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC45948.1 - 0.029 14.2 0.0 0.037 13.9 0.0 1.3 1 1 0 1 1 1 0 Occluded RNA-recognition motif Reprolysin_2 PF13574.6 EFC45949.1 - 0.069 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PhoPQ_related PF10142.9 EFC45950.1 - 1.1e-93 313.8 0.4 1.1e-93 313.8 0.4 1.6 2 0 0 2 2 2 1 PhoPQ-activated pathogenicity-related protein DUF4261 PF14080.6 EFC45950.1 - 0.073 13.2 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) SymE_toxin PF08845.10 EFC45951.1 - 0.049 13.7 0.0 0.093 12.8 0.0 1.5 1 0 0 1 1 1 0 Toxin SymE, type I toxin-antitoxin system Pkinase PF00069.25 EFC45952.1 - 3.9e-35 121.5 0.1 4.3e-35 121.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC45952.1 - 2.2e-19 69.8 0.0 2.4e-19 69.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC45952.1 - 0.00078 19.4 0.0 0.017 15.0 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC45952.1 - 0.011 14.8 0.1 0.018 14.1 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 EFC45952.1 - 0.029 13.2 0.0 0.041 12.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 EFC45952.1 - 0.057 12.7 0.0 0.11 11.8 0.0 1.4 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 EFC45952.1 - 0.06 12.3 0.3 0.1 11.5 0.3 1.5 1 1 0 1 1 1 0 Haspin like kinase domain PhoU PF01895.19 EFC45953.1 - 3.6 8.1 5.5 0.99 9.9 0.1 2.9 4 0 0 4 4 4 0 PhoU domain CPSF100_C PF13299.6 EFC45953.1 - 6.1 7.0 23.0 21 5.3 5.8 5.0 4 0 0 4 4 4 0 Cleavage and polyadenylation factor 2 C-terminal F-box PF00646.33 EFC45954.1 - 0.00079 19.2 0.4 0.00079 19.2 0.4 3.6 4 0 0 4 4 4 1 F-box domain F-box-like PF12937.7 EFC45954.1 - 0.0017 18.2 1.0 0.0067 16.3 0.1 2.3 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 EFC45954.1 - 0.032 14.3 35.4 0.067 13.3 0.1 10.1 12 0 0 12 12 12 0 Leucine Rich repeat HpcH_HpaI PF03328.14 EFC45955.1 - 2.6e-34 118.3 0.0 3.3e-34 117.9 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 EFC45955.1 - 4.3e-12 45.9 0.1 2.7e-09 36.6 0.1 2.2 1 1 0 1 1 1 1 C-C_Bond_Lyase of the TIM-Barrel fold GTP_EFTU PF00009.27 EFC45956.1 - 1.9e-32 112.4 0.0 1.9e-32 112.4 0.0 2.8 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 EFC45956.1 - 6.7e-19 67.6 0.0 2.1e-18 66.0 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 IF-2 PF11987.8 EFC45956.1 - 5e-18 65.2 2.0 2e-17 63.3 0.1 2.9 3 0 0 3 3 3 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 EFC45956.1 - 4.7e-11 42.9 11.8 5e-09 36.4 0.1 3.5 3 0 0 3 3 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC45956.1 - 2.2e-08 34.2 0.7 2.2e-07 30.9 0.1 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EFC45956.1 - 4.5e-05 23.6 0.0 0.00017 21.8 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 EFC45956.1 - 5.5e-05 23.1 0.1 0.00019 21.3 0.1 2.0 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFC45956.1 - 0.0029 17.5 5.3 0.078 12.9 0.5 3.1 2 1 1 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 EFC45956.1 - 0.0042 16.6 0.4 0.027 14.0 0.4 2.4 1 1 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.22 EFC45956.1 - 0.0074 15.9 0.3 0.076 12.6 0.1 2.7 2 1 0 2 2 2 1 Ras family NT5C PF06941.12 EFC45956.1 - 0.013 15.4 0.0 0.025 14.4 0.0 1.4 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Presenilin PF01080.17 EFC45956.1 - 1.6 7.4 13.5 2.8 6.6 13.5 1.3 1 0 0 1 1 1 0 Presenilin TSP_1 PF00090.19 EFC45957.1 - 0.013 15.7 0.8 5.4 7.3 0.1 2.6 2 0 0 2 2 2 0 Thrombospondin type 1 domain LRR_8 PF13855.6 EFC45958.1 - 1.5e-40 136.8 49.3 5.1e-10 39.0 4.3 8.2 3 2 6 9 9 9 9 Leucine rich repeat LRR_4 PF12799.7 EFC45958.1 - 3e-25 87.9 66.8 1.6e-05 25.2 0.5 10.6 1 1 9 13 13 13 12 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC45958.1 - 5.6e-08 32.3 49.7 2.8 8.8 0.0 13.4 13 0 0 13 13 13 5 Leucine Rich Repeat LRR_5 PF13306.6 EFC45958.1 - 0.00022 21.2 18.5 0.0082 16.1 1.6 3.9 1 1 2 4 4 4 2 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 EFC45958.1 - 2.5 8.4 49.2 7.1 7.0 0.3 11.3 12 0 0 12 12 12 0 Leucine Rich repeat Ras PF00071.22 EFC45959.1 - 7.6e-28 97.1 0.1 1.7e-17 63.5 0.0 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFC45959.1 - 1.1e-07 32.1 0.0 1.7e-05 25.0 0.0 2.3 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45959.1 - 1e-05 25.1 0.0 0.0011 18.4 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC45959.1 - 0.001 19.0 0.0 0.26 11.2 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC45959.1 - 0.008 15.7 0.0 0.16 11.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 EFC45959.1 - 0.021 15.1 0.0 0.034 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF1366 PF07104.11 EFC45959.1 - 0.022 14.4 0.0 0.053 13.2 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1366) ABC_tran PF00005.27 EFC45959.1 - 0.079 13.5 0.0 0.11 13.0 0.0 1.3 1 1 0 1 1 1 0 ABC transporter LpxK PF02606.14 EFC45959.1 - 0.12 11.4 0.0 0.21 10.6 0.0 1.4 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase Acetyltransf_10 PF13673.7 EFC45960.1 - 7.9e-08 32.3 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC45960.1 - 1.7e-06 28.4 0.0 2.6e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC45960.1 - 2.5e-06 27.7 0.0 3.4e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_CG PF14542.6 EFC45960.1 - 0.078 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFC45960.1 - 0.092 12.7 0.0 0.21 11.6 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein PCI PF01399.27 EFC45961.1 - 6.4e-21 74.8 0.2 6.4e-21 74.8 0.2 3.3 3 1 0 3 3 3 1 PCI domain Rpn3_C PF08375.11 EFC45961.1 - 1.8e-15 57.1 2.8 1.8e-15 57.1 2.8 3.5 2 2 0 2 2 2 1 Proteasome regulatory subunit C-terminal Ripply PF14998.6 EFC45961.1 - 0.26 11.9 0.0 0.26 11.9 0.0 3.4 2 1 1 3 3 3 0 Transcription Regulator ATP-synt_F PF01990.17 EFC45962.1 - 7.2e-32 109.6 0.0 8.4e-32 109.4 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit Ins145_P3_rec PF08709.11 EFC45963.1 - 0.0011 18.2 0.7 0.058 12.6 0.1 2.2 1 1 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor CDP-OH_P_transf PF01066.21 EFC45964.1 - 1.3e-13 51.5 0.1 1.3e-13 51.5 0.1 3.0 3 2 0 3 3 3 1 CDP-alcohol phosphatidyltransferase CPBP PF02517.16 EFC45965.1 - 5.4e-11 42.7 3.9 5.4e-11 42.7 3.9 3.1 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease Pox_LP_H2 PF03356.15 EFC45965.1 - 0.021 14.7 0.0 0.052 13.4 0.0 1.6 1 0 0 1 1 1 0 Viral late protein H2 SMP_2 PF10144.9 EFC45968.1 - 0.07 12.8 0.3 0.076 12.7 0.3 1.1 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin C_tripleX PF02363.19 EFC45968.1 - 1.8 9.0 7.5 7.7 7.0 1.0 2.2 2 0 0 2 2 2 0 Cysteine rich repeat Neurokinin_B PF03823.14 EFC45968.1 - 7.5 6.7 5.9 33 4.6 1.5 2.3 2 0 0 2 2 2 0 Neurokinin B HSP70 PF00012.20 EFC45969.1 - 3.1e-222 739.0 9.1 3.6e-222 738.8 9.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC45969.1 - 5.7e-16 58.3 0.2 9.6e-13 47.6 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein Hydantoinase_A PF01968.18 EFC45969.1 - 0.017 14.4 1.7 0.088 12.0 0.1 2.7 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase FGGY_C PF02782.16 EFC45969.1 - 0.025 14.3 0.0 0.058 13.1 0.0 1.6 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EFC45969.1 - 0.049 13.1 0.0 0.16 11.5 0.0 1.8 1 1 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 EFC45969.1 - 0.18 12.2 4.0 0.32 11.5 0.3 2.9 2 2 0 2 2 2 0 Cell division protein FtsA NPL PF17800.1 EFC45970.1 - 0.0029 18.1 0.1 0.0029 18.1 0.1 3.8 2 2 0 2 2 2 1 Nucleoplasmin-like domain Spt20 PF12090.8 EFC45970.1 - 1.9 8.1 21.6 0.86 9.2 19.3 1.7 2 0 0 2 2 2 0 Spt20 family DUF1198 PF06711.11 EFC45971.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) Ras PF00071.22 EFC45972.1 - 6.5e-56 188.4 0.0 7.5e-56 188.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45972.1 - 3.1e-32 111.3 0.0 4.2e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45972.1 - 1.4e-14 54.0 0.0 1.6e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC45972.1 - 4.2e-08 33.3 0.0 6.2e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC45972.1 - 9.3e-06 25.3 0.1 0.00089 18.8 0.1 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC45972.1 - 3.5e-05 23.8 0.0 0.003 17.5 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EFC45972.1 - 7.5e-05 22.2 0.0 8.3e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 EFC45972.1 - 0.0049 16.6 0.0 0.11 12.2 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EFC45972.1 - 0.0073 16.6 0.0 0.017 15.4 0.0 1.7 2 1 1 3 3 2 1 AAA domain SRPRB PF09439.10 EFC45972.1 - 0.0083 15.6 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 EFC45972.1 - 0.012 15.2 0.1 0.018 14.5 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Septin PF00735.18 EFC45972.1 - 0.014 14.7 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 Septin AAA_24 PF13479.6 EFC45972.1 - 0.021 14.6 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFC45972.1 - 0.022 14.8 0.0 0.03 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC45972.1 - 0.022 15.1 0.0 0.034 14.5 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 EFC45972.1 - 0.024 14.2 0.0 0.061 12.9 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EFC45972.1 - 0.031 14.2 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 NTPase ATP_bind_1 PF03029.17 EFC45972.1 - 0.036 13.8 0.2 1.7 8.4 0.0 2.4 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.20 EFC45972.1 - 0.059 12.5 0.4 0.36 10.0 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit ATPase_2 PF01637.18 EFC45972.1 - 0.067 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 EFC45972.1 - 0.084 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 EFC45972.1 - 0.087 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 EFC45972.1 - 0.092 11.9 0.0 0.13 11.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain DUF725 PF05267.12 EFC45972.1 - 0.15 12.1 0.0 0.74 9.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF725) MCM PF00493.23 EFC45972.1 - 0.17 11.0 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain DAP3 PF10236.9 EFC45972.1 - 0.19 10.9 0.1 0.26 10.4 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mem_trans PF03547.18 EFC45973.1 - 3e-28 98.3 10.8 4.2e-28 97.8 10.8 1.2 1 0 0 1 1 1 1 Membrane transport protein DUF2207 PF09972.9 EFC45973.1 - 0.26 10.0 0.0 0.26 10.0 0.0 2.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) UFD1 PF03152.14 EFC45974.1 - 1.6e-40 138.4 0.4 3.4e-40 137.3 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 UBX PF00789.20 EFC45974.1 - 9.4e-07 29.0 0.0 3.9e-06 27.0 0.0 2.2 1 0 0 1 1 1 1 UBX domain FadA PF09403.10 EFC45974.1 - 2e-05 25.0 10.9 0.00037 20.9 5.3 2.6 2 0 0 2 2 2 2 Adhesion protein FadA UQ_con PF00179.26 EFC45974.1 - 5.4e-05 22.9 0.3 0.00025 20.7 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme Methyltransf_3 PF01596.17 EFC45975.1 - 9.6e-34 116.4 0.0 1.2e-33 116.1 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EFC45975.1 - 2.2e-11 44.7 0.0 3.3e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFC45975.1 - 7.2e-09 35.7 0.0 9.8e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.7 EFC45975.1 - 0.00037 20.5 0.0 0.00063 19.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 EFC45975.1 - 0.0017 18.1 0.0 0.0023 17.6 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.6 EFC45975.1 - 0.0021 18.7 0.0 0.0037 18.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain TRM PF02005.16 EFC45975.1 - 0.01 15.0 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase UPF0020 PF01170.18 EFC45975.1 - 0.041 13.5 0.0 0.061 13.0 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 EFC45975.1 - 0.062 12.9 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 EFC45975.1 - 0.077 12.6 0.0 0.097 12.3 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 DUF1918 PF08940.11 EFC45975.1 - 0.89 9.2 2.2 1.6 8.4 0.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1918) zf-4CXXC_R1 PF10497.9 EFC45976.1 - 1.4e-11 44.5 9.4 1.4e-11 44.5 9.4 2.8 3 0 0 3 3 3 1 Zinc-finger domain of monoamine-oxidase A repressor R1 EF-hand_7 PF13499.6 EFC45978.1 - 4.4e-06 27.1 3.5 1.1e-05 25.8 2.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC45978.1 - 0.0071 16.2 4.2 0.12 12.4 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC45978.1 - 0.013 15.0 5.5 0.094 12.3 0.2 3.1 2 1 0 2 2 2 0 EF hand EF-hand_5 PF13202.6 EFC45978.1 - 0.03 13.8 2.2 0.54 9.8 0.1 2.8 2 0 0 2 2 2 0 EF hand Ras PF00071.22 EFC45979.1 - 2.4e-53 180.0 0.0 2.7e-53 179.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC45979.1 - 5e-24 84.8 0.0 7e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC45979.1 - 7.9e-11 41.7 0.0 1.2e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC45979.1 - 0.00046 19.8 0.0 0.0009 18.8 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SPRY PF00622.28 EFC45980.1 - 4e-07 30.2 0.1 7.7e-07 29.2 0.1 1.4 1 0 0 1 1 1 1 SPRY domain SipA_VBS PF17985.1 EFC45980.1 - 0.016 15.0 0.2 0.041 13.7 0.2 1.7 1 0 0 1 1 1 0 SipA vinculin binding site DUF1319 PF07028.11 EFC45980.1 - 0.11 12.8 5.7 0.27 11.5 5.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) Cyt-b5 PF00173.28 EFC45981.1 - 2.9e-08 33.7 0.0 3.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DDE_Tnp_4 PF13359.6 EFC45982.1 - 4.5e-05 23.2 0.1 8.5e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Ceramidase_alk PF04734.13 EFC45983.1 - 9.6e-211 700.8 0.0 1.1e-210 700.6 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 EFC45983.1 - 3.7e-51 173.3 0.2 5.5e-51 172.8 0.2 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal DUF359 PF04019.12 EFC45984.1 - 0.2 11.3 0.0 0.64 9.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF359) NIF PF03031.18 EFC45985.1 - 4.9e-37 127.1 0.0 5.7e-37 126.9 0.0 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 EFC45985.1 - 0.0044 17.4 0.4 0.13 12.7 0.0 2.6 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFC45985.1 - 0.056 13.7 0.1 12 6.1 0.1 2.3 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Peptidase_S24 PF00717.23 EFC45985.1 - 0.097 12.6 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Peptidase S24-like Acid_phosphat_B PF03767.14 EFC45985.1 - 0.2 11.2 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) RE_NgoPII PF09521.10 EFC45986.1 - 0.0042 16.3 0.1 0.0061 15.8 0.1 1.3 1 0 0 1 1 1 1 NgoPII restriction endonuclease SHOCT PF09851.9 EFC45987.1 - 8.9e-05 22.1 4.2 8.9e-05 22.1 4.2 2.2 2 0 0 2 2 2 1 Short C-terminal domain Trypan_PARP PF05887.11 EFC45987.1 - 0.17 11.9 3.4 0.45 10.5 3.4 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ig_4 PF16680.5 EFC45987.1 - 0.21 11.9 1.0 1 9.6 0.2 2.6 3 0 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain KASH_CCD PF14662.6 EFC45988.1 - 4.6e-06 26.6 17.8 0.0006 19.7 17.8 2.2 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH JIP_LZII PF16471.5 EFC45988.1 - 1e-05 25.6 30.9 0.0002 21.5 16.3 2.8 1 1 2 3 3 3 2 JNK-interacting protein leucine zipper II Shugoshin_N PF07558.11 EFC45988.1 - 1.8e-05 24.5 11.6 0.069 13.0 4.7 3.7 2 1 2 4 4 4 2 Shugoshin N-terminal coiled-coil region VGPC1_C PF16799.5 EFC45988.1 - 3.7e-05 23.6 8.3 0.081 12.9 0.4 3.9 2 1 2 4 4 3 2 C-terminal membrane-localisation domain of ion-channel, VCN1 bZIP_1 PF00170.21 EFC45988.1 - 0.002 18.2 29.2 0.32 11.1 5.2 3.4 1 1 2 3 3 3 2 bZIP transcription factor RNase_E_G PF10150.9 EFC45988.1 - 0.0027 17.2 4.3 0.0033 16.9 4.3 1.2 1 0 0 1 1 1 1 Ribonuclease E/G family Taxilin PF09728.9 EFC45988.1 - 0.0035 16.6 20.8 0.0043 16.3 20.8 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein Atg14 PF10186.9 EFC45988.1 - 0.01 14.9 8.7 0.013 14.6 8.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_2 PF07716.15 EFC45988.1 - 0.015 15.4 24.2 0.065 13.3 4.2 3.7 1 1 3 4 4 4 0 Basic region leucine zipper Jnk-SapK_ap_N PF09744.9 EFC45988.1 - 0.019 15.2 12.2 0.033 14.4 12.2 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ZapB PF06005.12 EFC45988.1 - 0.039 14.4 24.7 1.5 9.3 14.0 3.4 1 1 2 3 3 3 0 Cell division protein ZapB DUF2205 PF10224.9 EFC45988.1 - 0.08 13.0 23.7 0.46 10.5 10.8 3.8 1 1 2 3 3 3 0 Short coiled-coil protein CALCOCO1 PF07888.11 EFC45988.1 - 0.08 11.8 16.7 0.11 11.4 16.7 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 EFC45988.1 - 0.083 12.2 23.4 0.17 11.2 23.4 1.5 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF2312 PF10073.9 EFC45988.1 - 0.087 12.5 14.3 0.22 11.2 2.9 3.0 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) GIT_CC PF16559.5 EFC45988.1 - 0.092 12.6 11.5 0.093 12.6 0.7 3.4 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor M PF02370.16 EFC45988.1 - 0.1 13.2 3.6 0.1 13.2 3.6 4.7 4 0 0 4 4 3 0 M protein repeat PRKG1_interact PF15898.5 EFC45988.1 - 0.12 13.3 18.5 3.4 8.6 2.6 3.4 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 EFC45988.1 - 0.16 11.8 23.8 0.23 11.2 3.3 3.2 1 1 2 3 3 3 0 Septum formation initiator DUF3552 PF12072.8 EFC45988.1 - 0.18 11.2 17.1 0.29 10.5 17.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) HALZ PF02183.18 EFC45988.1 - 0.2 11.9 26.4 2 8.7 5.0 3.8 1 1 2 3 3 3 0 Homeobox associated leucine zipper Spc7 PF08317.11 EFC45988.1 - 0.2 10.5 19.5 1 8.2 19.4 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4201 PF13870.6 EFC45988.1 - 0.21 11.3 22.4 0.1 12.3 12.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF4988 PF16378.5 EFC45988.1 - 0.27 10.9 5.5 0.49 10.0 5.3 1.6 1 1 0 1 1 1 0 Domain of unknown function CENP-H PF05837.12 EFC45988.1 - 0.3 11.5 18.7 2.8 8.4 8.4 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) TMPIT PF07851.13 EFC45988.1 - 0.32 10.2 11.0 0.44 9.7 11.0 1.2 1 0 0 1 1 1 0 TMPIT-like protein Leu_zip PF15294.6 EFC45988.1 - 0.34 10.4 21.1 0.77 9.2 12.2 2.2 1 1 1 2 2 2 0 Leucine zipper Ureide_permease PF07168.11 EFC45988.1 - 0.41 9.4 3.2 0.53 9.0 3.2 1.1 1 0 0 1 1 1 0 Ureide permease ADIP PF11559.8 EFC45988.1 - 0.44 10.6 19.2 1 9.5 19.2 1.6 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding FAM176 PF14851.6 EFC45988.1 - 0.44 10.2 4.5 0.68 9.6 4.5 1.3 1 0 0 1 1 1 0 FAM176 family Exonuc_VII_L PF02601.15 EFC45988.1 - 0.45 10.0 6.5 0.53 9.8 6.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1515 PF07439.11 EFC45988.1 - 0.45 10.6 8.3 0.29 11.2 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Yuri_gagarin PF15934.5 EFC45988.1 - 0.68 9.7 15.6 0.97 9.2 15.6 1.2 1 0 0 1 1 1 0 Yuri gagarin DUF1664 PF07889.12 EFC45988.1 - 0.7 9.9 11.9 0.58 10.2 6.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 EFC45988.1 - 0.77 9.5 10.7 4.2 7.1 1.8 2.5 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain ATG16 PF08614.11 EFC45988.1 - 0.89 9.7 18.6 34 4.6 18.3 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) NEMO PF11577.8 EFC45988.1 - 0.97 9.5 23.0 2.3 8.3 11.5 2.5 1 1 1 2 2 2 0 NF-kappa-B essential modulator NEMO Syntaxin PF00804.25 EFC45988.1 - 1 9.0 17.4 0.97 9.1 14.0 1.9 1 1 1 2 2 2 0 Syntaxin DUF1465 PF07323.12 EFC45988.1 - 1.1 9.1 6.3 1.6 8.5 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) Rootletin PF15035.6 EFC45988.1 - 1.2 9.1 16.6 4.8 7.1 4.6 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion BAH PF01426.18 EFC45988.1 - 1.3 8.9 8.7 9.3 6.1 7.4 2.5 2 1 0 2 2 2 0 BAH domain DCB PF16213.5 EFC45988.1 - 1.4 8.5 11.3 38 3.9 11.3 2.4 1 1 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 YabA PF06156.13 EFC45988.1 - 1.4 9.6 18.8 4.6 7.9 11.5 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Imm7 PF15585.6 EFC45988.1 - 2 8.7 4.7 1.7 8.9 1.6 1.9 1 1 1 2 2 2 0 Immunity protein 7 PspB PF06667.12 EFC45988.1 - 2 8.5 8.0 47 4.1 0.3 3.9 1 1 3 4 4 4 0 Phage shock protein B CtIP_N PF10482.9 EFC45988.1 - 2.8 8.0 18.9 12 6.0 17.7 2.9 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain NRBF2 PF08961.10 EFC45988.1 - 4.6 6.8 21.4 4.6 6.8 3.6 2.2 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Striatin PF08232.12 EFC45988.1 - 4.9 7.7 15.8 1.4e+02 3.0 15.8 2.2 1 1 0 1 1 1 0 Striatin family DUF3450 PF11932.8 EFC45988.1 - 5.4 6.2 10.9 5.6 6.2 1.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) EcKinase PF02958.20 EFC45989.1 - 1.2e-16 61.0 0.1 4.5e-12 45.9 0.1 2.2 1 1 1 2 2 2 2 Ecdysteroid kinase APH PF01636.23 EFC45989.1 - 3e-09 37.1 0.0 4.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 EFC45989.1 - 9.1e-06 24.8 0.0 3.2e-05 23.0 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 EFC45989.1 - 0.012 15.2 0.1 0.02 14.5 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase NHL PF01436.21 EFC45990.1 - 1.2e-51 170.2 0.1 0.00089 19.2 0.1 13.4 13 0 0 13 13 13 11 NHL repeat EGF_2 PF07974.13 EFC45990.1 - 6.3e-16 58.5 44.5 2.1e-05 24.8 8.7 3.5 3 0 0 3 3 3 3 EGF-like domain Phytase-like PF13449.6 EFC45990.1 - 0.00092 19.2 0.6 2.5 8.0 0.0 4.3 4 1 1 5 5 5 2 Esterase-like activity of phytase hEGF PF12661.7 EFC45990.1 - 0.0024 18.4 37.5 0.22 12.2 5.2 3.9 3 0 0 3 3 3 3 Human growth factor-like EGF EGF PF00008.27 EFC45990.1 - 0.05 13.9 30.4 0.23 11.8 5.7 3.6 3 0 0 3 3 3 0 EGF-like domain potato_inhibit PF00280.18 EFC45990.1 - 0.19 12.4 0.0 3 8.6 0.0 2.9 2 0 0 2 2 2 0 Potato inhibitor I family PapC_C PF13953.6 EFC45990.1 - 0.59 10.0 3.7 6.4 6.7 0.4 3.2 2 0 0 2 2 2 0 PapC C-terminal domain DUF1939 PF09154.10 EFC45990.1 - 0.98 9.6 4.1 52 4.1 0.1 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF1939) LRR_6 PF13516.6 EFC45991.1 - 2.2e-32 108.3 35.7 0.00012 21.9 0.1 13.8 13 0 0 13 13 13 10 Leucine Rich repeat LRR_4 PF12799.7 EFC45991.1 - 3.7e-25 87.6 51.9 0.00075 19.8 0.6 10.1 4 2 1 9 9 9 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC45991.1 - 8.7e-23 79.9 41.0 3.1e-07 30.0 4.6 7.4 4 3 5 9 9 9 7 Leucine rich repeat LRR_9 PF14580.6 EFC45991.1 - 8.8e-09 35.1 11.8 0.0004 19.9 0.3 4.6 2 2 3 5 5 5 2 Leucine-rich repeat LRR_1 PF00560.33 EFC45991.1 - 1.3e-06 28.1 33.4 2.5 9.0 0.0 11.8 13 0 0 13 13 13 2 Leucine Rich Repeat DUF3719 PF12516.8 EFC45991.1 - 0.062 13.0 0.1 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) F-box PF00646.33 EFC45991.1 - 0.14 12.0 0.3 0.54 10.2 0.1 2.0 2 0 0 2 2 2 0 F-box domain GST_N PF02798.20 EFC45992.1 - 1.5e-18 66.9 0.0 2.4e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC45992.1 - 3.6e-16 59.3 0.0 5.9e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC45992.1 - 4.9e-14 52.3 0.0 6.6e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 EFC45992.1 - 9.1e-14 51.5 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC45992.1 - 1.4e-05 25.2 0.0 2.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC45992.1 - 0.0031 17.5 0.0 0.0059 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain AAA_12 PF13087.6 EFC45993.1 - 2e-71 239.8 0.1 2e-71 239.8 0.1 3.5 4 0 0 4 4 4 1 AAA domain AAA_11 PF13086.6 EFC45993.1 - 1.7e-50 172.2 5.2 1.7e-50 172.2 5.2 5.4 5 2 0 5 5 5 1 AAA domain AAA_19 PF13245.6 EFC45993.1 - 3.5e-05 24.2 1.7 0.0052 17.1 0.3 3.0 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFC45993.1 - 0.0066 16.2 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 EFC45993.1 - 0.033 14.0 0.0 0.072 12.9 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 EFC45993.1 - 9.9 6.0 7.7 18 5.1 0.0 3.5 3 0 0 3 3 3 0 Helicase Arylesterase PF01731.20 EFC45994.1 - 0.0036 17.5 0.0 0.012 15.8 0.0 1.9 1 0 0 1 1 1 1 Arylesterase Tristanin_u2 PF16638.5 EFC45995.1 - 0.044 14.6 0.1 0.12 13.2 0.1 1.7 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers DUF5490 PF17593.2 EFC45995.1 - 0.12 12.3 0.8 0.64 10.1 0.8 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5490) HTH_32 PF13565.6 EFC45995.1 - 0.83 10.3 3.3 14 6.4 0.1 3.7 3 0 0 3 3 3 0 Homeodomain-like domain DUF3972 PF13118.6 EFC45996.1 - 1 9.8 4.4 34 4.9 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3972) AAA PF00004.29 EFC45997.1 - 4.1e-63 211.7 0.0 5.8e-42 143.2 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC45997.1 - 1e-19 70.1 0.2 9e-12 44.6 0.2 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 EFC45997.1 - 9e-13 49.0 0.1 4.3e-06 27.2 0.0 3.4 2 1 1 3 3 3 2 AAA ATPase domain RNA_helicase PF00910.22 EFC45997.1 - 1e-07 32.3 0.0 0.0022 18.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase RuvB_N PF05496.12 EFC45997.1 - 1.6e-06 28.0 0.0 0.00012 21.8 0.0 2.8 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC45997.1 - 5.6e-06 26.7 0.4 0.036 14.3 0.0 3.9 3 2 0 3 3 3 2 AAA domain AAA_5 PF07728.14 EFC45997.1 - 5.9e-06 26.3 0.1 0.01 15.8 0.0 3.7 3 2 0 3 3 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFC45997.1 - 3.5e-05 23.6 0.1 0.019 14.7 0.1 3.2 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 EFC45997.1 - 5.4e-05 23.4 0.0 0.52 10.5 0.0 3.2 4 0 0 4 4 3 2 AAA domain AAA_7 PF12775.7 EFC45997.1 - 0.00021 20.8 0.0 0.41 10.1 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_2 PF07724.14 EFC45997.1 - 0.00047 20.3 0.0 0.013 15.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 EFC45997.1 - 0.00049 20.1 0.0 1.1 9.3 0.0 3.2 3 0 0 3 3 2 2 AAA domain TIP49 PF06068.13 EFC45997.1 - 0.00074 18.8 0.0 0.0095 15.2 0.0 2.2 2 0 0 2 2 2 1 TIP49 P-loop domain NACHT PF05729.12 EFC45997.1 - 0.00084 19.3 0.0 0.2 11.6 0.0 3.1 3 0 0 3 3 3 1 NACHT domain DUF815 PF05673.13 EFC45997.1 - 0.00088 18.5 0.1 0.25 10.5 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.15 EFC45997.1 - 0.0018 18.3 0.1 0.22 11.4 0.0 2.8 2 0 0 2 2 2 1 Rad17 P-loop domain IstB_IS21 PF01695.17 EFC45997.1 - 0.0023 17.7 0.0 0.3 10.8 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein RsgA_GTPase PF03193.16 EFC45997.1 - 0.0032 17.4 0.6 0.017 15.0 0.3 2.3 3 0 0 3 3 3 1 RsgA GTPase DUF2075 PF09848.9 EFC45997.1 - 0.0057 15.9 0.1 0.018 14.3 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 EFC45997.1 - 0.0058 17.1 0.8 0.87 10.1 0.5 3.2 2 1 0 2 2 2 1 ABC transporter Mg_chelatase PF01078.21 EFC45997.1 - 0.0064 15.9 0.1 0.37 10.1 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Vps4_C PF09336.10 EFC45997.1 - 0.0082 16.1 0.0 0.054 13.5 0.0 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain DNA_pol3_delta2 PF13177.6 EFC45997.1 - 0.016 15.0 0.1 0.22 11.3 0.1 2.5 2 1 0 2 2 2 0 DNA polymerase III, delta subunit NB-ARC PF00931.22 EFC45997.1 - 0.021 14.0 0.1 0.21 10.8 0.1 2.2 2 0 0 2 2 2 0 NB-ARC domain TsaE PF02367.17 EFC45997.1 - 0.026 14.5 0.1 11 6.1 0.0 2.8 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TniB PF05621.11 EFC45997.1 - 0.029 13.8 0.3 1.2 8.5 0.0 3.0 3 0 0 3 3 3 0 Bacterial TniB protein ATPase_2 PF01637.18 EFC45997.1 - 0.044 13.7 0.1 3.5 7.5 0.1 3.2 2 2 1 3 3 3 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 EFC45997.1 - 0.07 12.9 0.0 17 5.1 0.0 2.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 EFC45997.1 - 0.075 12.9 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) 5-FTHF_cyc-lig PF01812.20 EFC45997.1 - 0.18 11.7 0.4 0.48 10.3 0.4 1.7 1 0 0 1 1 1 0 5-formyltetrahydrofolate cyclo-ligase family Homeobox_KN PF05920.11 EFC45999.1 - 1.1e-20 73.2 0.7 1.4e-20 72.9 0.7 1.1 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC45999.1 - 4.8e-09 35.9 0.0 5.3e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 EFC45999.1 - 0.02 14.3 0.0 0.024 14.1 0.0 1.2 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez BRCT PF00533.26 EFC46001.1 - 2.1e-08 34.4 3.6 1.8e-05 25.0 0.0 3.7 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFC46001.1 - 2.8e-07 30.4 0.0 1.1e-06 28.4 0.0 2.1 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EFC46001.1 - 6.4e-07 29.7 6.0 0.011 16.1 0.0 3.4 4 0 0 4 4 4 2 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFC46001.1 - 0.0055 17.0 2.4 2.2 8.6 0.0 3.7 2 1 1 3 3 3 1 DNA ligase 3 BRCT domain RGS PF00615.19 EFC46002.1 - 3.1e-06 27.5 1.3 7e-06 26.3 1.3 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain LapA_dom PF06305.11 EFC46002.1 - 0.47 10.3 3.2 16 5.4 0.0 3.2 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Mito_carr PF00153.27 EFC46003.1 - 5.4e-40 135.2 10.4 1.1e-19 70.1 0.4 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein LD_cluster2 PF18163.1 EFC46003.1 - 0.06 12.9 0.0 0.086 12.4 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster2 PCMT PF01135.19 EFC46004.1 - 7e-66 222.0 0.1 8.2e-66 221.7 0.1 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 EFC46004.1 - 0.00066 19.2 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 EFC46004.1 - 0.013 15.3 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFC46004.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 EFC46004.1 - 0.042 13.7 0.0 0.058 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EFC46004.1 - 0.052 13.1 0.0 0.092 12.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain PGI PF00342.19 EFC46004.1 - 0.081 11.5 0.1 0.099 11.2 0.1 1.1 1 0 0 1 1 1 0 Phosphoglucose isomerase CMAS PF02353.20 EFC46004.1 - 0.14 11.5 0.0 0.33 10.2 0.0 1.6 1 1 1 2 2 2 0 Mycolic acid cyclopropane synthetase DUF4246 PF14033.6 EFC46005.1 - 2.7e-70 237.7 10.8 1.6e-43 149.5 0.2 3.4 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) RICTOR_M PF14666.6 EFC46006.1 - 0.0031 17.3 0.2 0.011 15.5 0.2 2.0 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, middle domain CNDH2_C PF16858.5 EFC46006.1 - 0.2 11.5 7.4 0.45 10.4 7.3 1.7 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PDE4_UCR PF18100.1 EFC46006.1 - 1.9 9.2 7.3 6.8 7.4 0.1 3.6 4 0 0 4 4 4 0 Phosphodiesterase 4 upstream conserved regions (UCR) PRANC PF09372.10 EFC46007.1 - 0.069 13.5 2.0 0.82 10.0 0.0 3.1 2 0 0 2 2 2 0 PRANC domain PAF PF15715.5 EFC46007.1 - 9.1 6.9 9.4 0.1 13.2 1.3 1.9 2 0 0 2 2 2 0 PCNA-associated factor histone like domain Pkinase PF00069.25 EFC46008.1 - 1.9e-75 253.6 0.0 2.2e-75 253.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46008.1 - 3e-37 128.3 0.0 3.4e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC46008.1 - 1.5e-08 34.4 0.0 2e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC46008.1 - 0.00048 20.1 0.0 0.00062 19.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 EFC46008.1 - 0.00099 18.8 0.3 0.0029 17.3 0.0 1.7 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EFC46008.1 - 0.0014 18.2 0.2 0.0024 17.5 0.2 1.5 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 EFC46008.1 - 0.0024 16.7 0.0 0.0028 16.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC46008.1 - 0.0038 16.2 0.3 0.005 15.8 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 EFC46008.1 - 0.0083 15.2 0.1 0.013 14.6 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 tRNA-synt_1g PF09334.11 EFC46009.1 - 1.5e-82 277.4 4.4 1.5e-82 277.4 4.4 2.4 2 1 0 2 2 2 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 EFC46009.1 - 5e-21 74.6 1.6 5.3e-12 44.8 0.6 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EFC46009.1 - 6.1e-05 22.5 1.0 0.0055 16.1 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 EFC46009.1 - 7.5e-05 21.8 0.5 0.035 13.0 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class I (K) Anticodon_1 PF08264.13 EFC46009.1 - 0.00053 20.0 0.1 0.0018 18.2 0.1 2.0 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA PTPA PF03095.15 EFC46009.1 - 0.011 15.3 2.7 0.31 10.5 0.1 3.0 3 0 0 3 3 3 0 Phosphotyrosyl phosphate activator (PTPA) protein YtxH PF12732.7 EFC46009.1 - 1.2 9.7 3.7 24 5.5 0.1 3.5 3 0 0 3 3 3 0 YtxH-like protein GBP PF02263.19 EFC46010.1 - 2.9e-19 69.4 0.4 2.9e-19 69.4 0.4 2.5 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 EFC46010.1 - 1.3e-09 37.9 23.2 3.1e-09 36.7 23.2 1.5 1 1 0 1 1 1 1 Guanylate-binding protein, C-terminal domain DUF2203 PF09969.9 EFC46010.1 - 0.73 10.6 9.7 1.3 9.8 0.2 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Methyltransf_14 PF08484.11 EFC46010.1 - 6.7 6.5 6.2 0.72 9.7 0.4 2.1 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain Thioredoxin PF00085.20 EFC46011.1 - 3.9e-17 62.1 0.0 0.00022 21.1 0.0 3.3 2 1 1 3 3 3 3 Thioredoxin Glutaredoxin PF00462.24 EFC46011.1 - 0.013 15.7 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 0 Glutaredoxin PPR_2 PF13041.6 EFC46012.1 - 0.53 10.5 4.8 0.21 11.8 0.3 2.6 3 0 0 3 3 3 0 PPR repeat family CRM1_repeat PF18777.1 EFC46012.1 - 1.6 8.3 5.0 2.4 7.8 1.9 2.7 3 0 0 3 3 3 0 Chromosome region maintenance or exportin repeat L27_2 PF09045.10 EFC46012.1 - 4 7.5 7.2 18 5.4 0.1 3.5 3 0 0 3 3 3 0 L27_2 RGS PF00615.19 EFC46013.1 - 3e-10 40.4 0.3 2.5e-09 37.4 0.3 2.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF3074 PF11274.8 EFC46013.1 - 0.0026 17.8 0.0 0.01 15.8 0.0 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) START PF01852.19 EFC46013.1 - 0.0038 16.7 0.0 0.0075 15.7 0.0 1.4 1 0 0 1 1 1 1 START domain CFIA_Pcf11 PF11526.8 EFC46013.1 - 3 8.4 6.1 0.51 10.9 1.4 2.2 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 Ras PF00071.22 EFC46014.1 - 1.8e-13 50.4 0.0 2.8e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46014.1 - 2e-06 28.0 0.0 3.4e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46014.1 - 0.00011 21.8 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Thioredoxin_8 PF13905.6 EFC46014.1 - 0.00019 21.7 0.5 0.00056 20.2 0.5 1.8 1 0 0 1 1 1 1 Thioredoxin-like DUF5457 PF17540.2 EFC46014.1 - 0.097 12.8 4.9 0.53 10.4 1.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5457) DUF2115 PF09888.9 EFC46014.1 - 0.12 12.9 2.2 0.22 12.0 0.7 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) AAA_16 PF13191.6 EFC46014.1 - 0.13 12.7 0.0 7.8 6.9 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain RNase_H PF00075.24 EFC46016.1 - 2.3e-17 63.5 1.5 5.8e-17 62.2 1.5 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EFC46016.1 - 0.0014 18.4 0.0 0.0033 17.2 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase-like zf-RVT PF13966.6 EFC46016.1 - 0.027 15.2 1.3 0.087 13.5 0.4 2.4 1 1 1 2 2 2 0 zinc-binding in reverse transcriptase dCMP_cyt_deam_1 PF00383.23 EFC46016.1 - 0.093 12.6 0.0 0.27 11.1 0.0 1.8 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Zip PF02535.22 EFC46017.1 - 2.7 7.1 5.0 4.3 6.5 5.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter PI31_Prot_C PF08577.11 EFC46019.1 - 1.6e-10 42.0 7.3 1.6e-10 42.0 7.3 1.9 2 0 0 2 2 2 1 PI31 proteasome regulator 7tm_7 PF08395.12 EFC46020.1 - 0.023 13.9 11.9 0.031 13.5 11.9 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor DUF975 PF06161.11 EFC46020.1 - 0.34 10.7 19.4 0.51 10.1 19.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF975) 7tm_1 PF00001.21 EFC46020.1 - 1 8.6 9.6 1.8 7.8 9.6 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) AA_permease_N PF08403.10 EFC46021.1 - 0.026 14.0 0.4 0.46 10.0 0.2 2.5 2 0 0 2 2 2 0 Amino acid permease N-terminal SPRY PF00622.28 EFC46021.1 - 0.067 13.3 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 SPRY domain DUF4094 PF13334.6 EFC46021.1 - 0.079 13.4 0.1 0.29 11.6 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) ATG16 PF08614.11 EFC46022.1 - 0.0016 18.7 28.3 0.0043 17.3 26.8 2.2 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) FliJ PF02050.16 EFC46022.1 - 0.0078 16.4 5.7 0.0078 16.4 5.7 3.1 1 1 2 3 3 3 1 Flagellar FliJ protein DUF4807 PF16065.5 EFC46022.1 - 0.011 15.4 3.9 0.021 14.5 3.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4807) ADIP PF11559.8 EFC46022.1 - 0.012 15.7 12.0 0.012 15.7 12.0 2.9 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding TACC_C PF05010.14 EFC46022.1 - 0.047 13.5 32.8 0.16 11.8 25.5 2.2 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TPR_MLP1_2 PF07926.12 EFC46022.1 - 0.061 13.4 30.1 1 9.4 5.3 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ERM PF00769.19 EFC46022.1 - 0.14 11.9 25.7 0.093 12.5 17.8 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family SPATA24 PF15175.6 EFC46022.1 - 0.45 10.4 32.4 1.2 9.0 9.4 3.2 1 1 2 3 3 3 0 Spermatogenesis-associated protein 24 Golgin_A5 PF09787.9 EFC46022.1 - 0.53 9.7 35.2 1.6 8.2 23.1 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 HAUS-augmin3 PF14932.6 EFC46022.1 - 0.61 9.6 28.6 1.2 8.7 17.9 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 YabA PF06156.13 EFC46022.1 - 0.64 10.7 31.0 1.1 9.9 2.8 3.8 1 1 2 3 3 3 0 Initiation control protein YabA Mod_r PF07200.13 EFC46022.1 - 1.8 8.6 35.0 0.46 10.6 19.9 2.5 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DivIVA PF05103.13 EFC46022.1 - 2.3 8.3 25.7 1.8 8.7 13.2 2.6 1 1 1 2 2 2 0 DivIVA protein HAP1_N PF04849.13 EFC46022.1 - 2.5 7.2 34.4 4.6 6.4 19.9 2.8 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Fez1 PF06818.15 EFC46022.1 - 2.6 8.5 30.7 0.32 11.4 19.1 2.1 1 1 1 2 2 2 0 Fez1 Laminin_II PF06009.12 EFC46022.1 - 4.2 7.4 24.1 0.18 11.8 12.5 2.6 1 1 1 2 2 2 0 Laminin Domain II DUF4140 PF13600.6 EFC46022.1 - 5 7.6 11.8 2.7 8.5 2.1 3.0 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) FliD_C PF07195.12 EFC46022.1 - 7.2 6.0 25.3 0.78 9.1 1.7 3.1 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus UPF0449 PF15136.6 EFC46022.1 - 7.6 7.1 26.5 0.16 12.4 1.6 3.9 1 1 3 4 4 4 0 Uncharacterised protein family UPF0449 Speriolin_N PF15058.6 EFC46022.1 - 9.2 6.3 12.1 1.6e+02 2.2 8.7 3.5 1 1 1 2 2 2 0 Speriolin N terminus TSC22 PF01166.18 EFC46022.1 - 10 6.6 26.3 5.6 7.4 0.1 5.4 2 2 3 5 5 5 0 TSC-22/dip/bun family DUF3287 PF11690.8 EFC46023.1 - 9.3e-05 22.2 1.0 9.3e-05 22.2 1.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF3287) Tup_N PF08581.10 EFC46023.1 - 0.00034 20.8 12.9 0.00034 20.8 12.9 4.0 4 1 0 4 4 4 1 Tup N-terminal GST_N_3 PF13417.6 EFC46024.1 - 7.8e-15 55.0 0.0 1.5e-14 54.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFC46024.1 - 5.2e-14 52.4 0.2 1e-13 51.4 0.1 1.5 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC46024.1 - 3.1e-10 40.2 0.0 5.4e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC46024.1 - 2.4e-05 24.4 0.0 5.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC46024.1 - 0.00011 22.2 0.0 0.0002 21.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 EFC46024.1 - 0.00037 20.7 0.0 0.001 19.2 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFC46024.1 - 0.004 17.9 0.1 0.0091 16.7 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain DUF4116 PF13475.6 EFC46025.1 - 6.3e-39 131.5 4.0 8.6e-17 60.6 0.2 6.7 5 2 2 7 7 7 5 Domain of unknown function (DUF4116) Ank_4 PF13637.6 EFC46026.1 - 2.2e-20 72.7 2.1 2.4e-11 43.9 0.0 2.9 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC46026.1 - 1.1e-18 67.6 0.0 3.6e-18 65.9 0.0 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC46026.1 - 2.6e-16 59.3 0.2 1.9e-07 31.2 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFC46026.1 - 5.4e-16 57.1 0.2 1.3e-06 28.2 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 EFC46026.1 - 1.8e-12 47.2 0.3 3e-05 24.2 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) DUF4116 PF13475.6 EFC46027.1 - 9e-78 255.8 58.6 8.1e-13 47.9 1.8 15.3 7 3 8 16 16 16 15 Domain of unknown function (DUF4116) DNA_primase_lrg PF04104.14 EFC46027.1 - 0.024 14.1 0.2 0.079 12.4 0.1 1.9 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit DUF3741 PF12552.8 EFC46027.1 - 1.5 8.8 12.8 3.3 7.7 0.1 5.1 6 0 0 6 6 6 0 Protein of unknown function (DUF3741) Beta_helix PF13229.6 EFC46028.1 - 1.8e-18 66.9 13.1 1.2e-10 41.5 8.4 2.9 2 1 1 3 3 3 2 Right handed beta helix region TPR_2 PF07719.17 EFC46028.1 - 1.1e-13 50.1 5.8 0.00095 19.1 0.4 6.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC46028.1 - 3.6e-09 36.1 1.0 4.2e-05 23.2 0.0 2.9 3 0 0 3 3 2 2 TPR repeat zf-MYND PF01753.18 EFC46028.1 - 4.9e-09 36.1 18.9 1.2e-08 34.9 18.9 1.8 1 0 0 1 1 1 1 MYND finger TPR_1 PF00515.28 EFC46028.1 - 7.6e-09 35.0 8.7 5e-05 22.9 0.8 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat NosD PF05048.13 EFC46028.1 - 4.5e-08 32.6 1.3 4.5e-08 32.6 1.3 3.2 2 1 1 3 3 3 2 Periplasmic copper-binding protein (NosD) TPR_12 PF13424.6 EFC46028.1 - 6.1e-06 26.4 4.1 0.11 12.8 0.0 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC46028.1 - 0.00014 22.4 0.3 0.57 10.9 0.7 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46028.1 - 0.00049 20.6 0.9 0.59 10.7 0.0 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46028.1 - 0.0016 18.6 1.0 3.4 8.3 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC46028.1 - 0.0047 17.0 0.2 0.026 14.7 0.3 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46028.1 - 0.019 15.2 12.5 0.081 13.2 1.1 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC46028.1 - 0.038 14.0 0.3 8.1 6.7 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_4 PF12799.7 EFC46028.1 - 0.066 13.7 39.2 0.79 10.2 0.5 8.4 4 3 5 9 9 9 0 Leucine Rich repeats (2 copies) TPR_14 PF13428.6 EFC46028.1 - 0.09 13.6 5.7 78 4.5 0.0 4.6 3 1 2 5 5 4 0 Tetratricopeptide repeat LRR_6 PF13516.6 EFC46028.1 - 2.2 8.5 22.9 0.097 12.8 0.5 7.4 7 0 0 7 7 6 0 Leucine Rich repeat zf-C6H2 PF15801.5 EFC46028.1 - 2.6 8.4 17.6 8 6.9 17.6 1.9 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding Peptidase_C1 PF00112.23 EFC46029.1 - 3.2e-63 213.8 3.5 3.6e-63 213.6 3.5 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC46029.1 - 5.6e-06 25.4 1.5 0.021 13.6 0.4 2.1 2 0 0 2 2 2 2 Peptidase C1-like family La PF05383.17 EFC46030.1 - 0.019 15.0 0.3 2.6 8.2 0.0 3.3 2 0 0 2 2 2 0 La domain Sel1 PF08238.12 EFC46031.1 - 3.8e-48 160.8 24.8 2.3e-08 34.4 0.7 8.5 9 0 0 9 9 9 7 Sel1 repeat TPR_7 PF13176.6 EFC46031.1 - 0.021 14.8 1.2 3.9 7.7 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat G-alpha PF00503.20 EFC46032.1 - 8.8e-60 202.7 5.3 1.2e-59 202.3 5.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_18 PF13238.6 EFC46032.1 - 0.002 18.7 0.0 0.0058 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain Arf PF00025.21 EFC46032.1 - 0.0073 15.8 0.0 0.59 9.6 0.1 2.7 2 0 0 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC46032.1 - 0.012 15.6 0.0 0.65 9.9 0.0 2.5 3 0 0 3 3 3 0 RsgA GTPase Erf4 PF10256.9 EFC46032.1 - 0.083 13.0 0.6 0.37 10.9 0.3 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family ATP_bind_1 PF03029.17 EFC46032.1 - 0.087 12.6 0.1 3.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein DUF815 PF05673.13 EFC46032.1 - 0.11 11.6 0.0 0.24 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) SMC_N PF02463.19 EFC46032.1 - 0.12 11.8 0.3 0.54 9.7 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFC46032.1 - 0.14 12.3 0.0 28 4.8 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase Mito_carr PF00153.27 EFC46033.1 - 1.1e-39 134.2 2.8 8.9e-18 64.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CN_hydrolase PF00795.22 EFC46034.1 - 1.6e-32 112.9 0.0 2.1e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 EFC46034.1 - 2.6e-31 108.6 0.4 2.3e-30 105.5 0.1 2.4 2 1 0 2 2 2 1 NAD synthase Pkinase PF00069.25 EFC46035.1 - 5.7e-46 157.0 0.0 1.1e-45 156.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46035.1 - 2.8e-26 92.4 0.0 4.8e-26 91.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC46035.1 - 0.0038 16.6 0.0 0.0057 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pro_isomerase PF00160.21 EFC46036.1 - 5.4e-36 124.3 0.1 5.4e-36 124.3 0.1 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 EFC46036.1 - 6.6e-15 54.7 0.2 1.5e-14 53.5 0.1 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC46036.1 - 0.00014 21.5 0.0 0.00032 20.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 EFC46036.1 - 0.075 13.0 0.1 0.19 11.8 0.1 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RGS PF00615.19 EFC46038.1 - 8.5e-20 71.2 5.3 2.2e-19 69.9 5.3 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain START PF01852.19 EFC46038.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 START domain Cas9_PI2 PF18070.1 EFC46039.1 - 0.084 13.6 0.0 0.34 11.7 0.0 2.1 1 0 0 1 1 1 0 CRISPR-Cas9 PI domain Pkinase PF00069.25 EFC46040.1 - 9.9e-43 146.4 0.0 2.2e-42 145.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46040.1 - 6.2e-41 140.4 0.0 2.6e-39 135.1 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase REJ PF02010.15 EFC46040.1 - 3.6e-17 62.3 10.0 6.2e-17 61.5 10.0 1.3 1 0 0 1 1 1 1 REJ domain EGF_2 PF07974.13 EFC46040.1 - 1.6e-14 53.9 271.1 0.00025 21.3 4.6 21.0 23 1 0 23 23 23 11 EGF-like domain NHL PF01436.21 EFC46040.1 - 1.2e-06 28.3 0.0 0.082 13.0 0.0 4.8 5 0 0 5 5 5 2 NHL repeat SGL PF08450.12 EFC46040.1 - 4.3e-05 23.2 0.1 1.9 8.0 0.0 4.0 4 0 0 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Laminin_EGF PF00053.24 EFC46040.1 - 0.019 15.1 222.1 0.94 9.7 14.0 14.6 8 4 6 14 14 14 0 Laminin EGF domain Alph_Pro_TM PF09608.10 EFC46040.1 - 0.044 13.6 0.0 0.093 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) APH PF01636.23 EFC46040.1 - 0.045 13.7 0.0 0.073 13.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Lipase_3 PF01764.25 EFC46041.1 - 2.4e-29 102.0 0.0 2.4e-29 102.0 0.0 2.4 2 1 0 2 2 2 1 Lipase (class 3) DUF2974 PF11187.8 EFC46041.1 - 4.9e-09 36.1 3.9 4.2e-08 33.0 3.9 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) PGAP1 PF07819.13 EFC46041.1 - 0.00034 20.4 0.3 0.00094 19.0 0.2 1.7 1 1 0 1 1 1 1 PGAP1-like protein Apolipoprotein PF01442.18 EFC46041.1 - 0.018 14.9 3.0 0.062 13.2 3.0 1.8 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Cutinase PF01083.22 EFC46041.1 - 0.019 14.9 0.0 0.046 13.7 0.0 1.7 1 0 0 1 1 1 0 Cutinase ECM11 PF15463.6 EFC46041.1 - 0.021 15.4 16.8 0.051 14.1 6.5 2.8 1 1 1 2 2 2 0 Extracellular mutant protein 11 Hydrolase_4 PF12146.8 EFC46041.1 - 0.047 13.0 0.0 0.16 11.2 0.0 1.9 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Baculo_PEP_C PF04513.12 EFC46041.1 - 1.9 8.6 4.9 62 3.6 0.0 3.3 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Oleosin PF01277.17 EFC46041.1 - 2.5 7.9 0.0 2.5 7.9 0.0 2.6 3 1 1 4 4 4 0 Oleosin Myf5 PF12232.8 EFC46043.1 - 0.04 14.7 0.5 14 6.5 0.1 2.6 2 0 0 2 2 2 0 Myogenic determination factor 5 TPR_10 PF13374.6 EFC46043.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TFIID_30kDa PF03540.13 EFC46043.1 - 0.15 12.1 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Transcription initiation factor TFIID 23-30kDa subunit EB PF01683.18 EFC46043.1 - 3 8.2 7.9 13 6.2 2.4 2.5 2 0 0 2 2 2 0 EB module Ribonuc_red_sm PF00268.21 EFC46044.1 - 1.6e-68 231.2 13.1 2e-68 230.9 13.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain PRANC PF09372.10 EFC46044.1 - 0.026 14.8 6.3 0.29 11.5 0.2 3.3 3 0 0 3 3 3 0 PRANC domain DUF2860 PF11059.8 EFC46045.1 - 0.07 12.4 0.0 0.085 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2860) COX5B PF01215.19 EFC46045.1 - 0.077 12.7 0.0 0.097 12.4 0.0 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb Pmp3 PF01679.17 EFC46046.1 - 1.9e-06 28.0 3.5 1.9e-06 28.0 3.5 2.4 2 0 0 2 2 2 2 Proteolipid membrane potential modulator RRM_Rrp7 PF17799.1 EFC46047.1 - 0.035 13.9 1.8 0.056 13.2 1.8 1.2 1 0 0 1 1 1 0 Rrp7 RRM-like N-terminal domain CUE PF02845.16 EFC46047.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 CUE domain LRR_4 PF12799.7 EFC46048.1 - 0.00033 21.0 23.9 0.12 12.9 0.4 5.3 2 2 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46048.1 - 0.001 18.7 13.3 0.42 10.4 0.1 4.3 2 1 3 5 5 5 4 Leucine rich repeat STN1_2 PF09170.10 EFC46048.1 - 0.0048 17.1 0.8 0.0079 16.4 0.8 1.4 1 0 0 1 1 1 1 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 LRR_6 PF13516.6 EFC46048.1 - 0.0056 16.6 6.1 2.7 8.2 0.0 4.6 5 0 0 5 5 5 2 Leucine Rich repeat 2-Hacid_dh PF00389.30 EFC46048.1 - 0.094 12.4 0.4 0.76 9.4 0.1 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Hemerythrin PF01814.23 EFC46050.1 - 7e-06 26.7 1.0 1.4e-05 25.7 1.0 1.5 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain Pkinase PF00069.25 EFC46051.1 - 4.9e-58 196.6 1.6 5.5e-58 196.4 1.6 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46051.1 - 2.1e-34 119.0 0.4 2.5e-34 118.7 0.4 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.9 EFC46051.1 - 0.011 15.3 0.5 0.026 14.0 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EFC46051.1 - 0.017 13.9 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 EFC46051.1 - 0.031 13.9 5.8 1.1 8.9 0.2 2.5 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 DUF1054 PF06335.12 EFC46051.1 - 0.076 12.9 0.0 0.17 11.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1054) APH PF01636.23 EFC46051.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RlaP PF10127.9 EFC46052.1 - 1.7e-23 83.5 6.5 4.3e-23 82.2 3.6 2.4 2 0 0 2 2 2 2 RNA repair pathway DNA polymerase beta family BPL_N PF09825.9 EFC46053.1 - 8.8e-11 41.5 0.0 1.8e-10 40.5 0.0 1.4 1 1 0 1 1 1 1 Biotin-protein ligase, N terminal SNO PF01174.19 EFC46053.1 - 0.0016 18.3 0.0 0.013 15.3 0.0 2.4 1 1 0 1 1 1 1 SNO glutamine amidotransferase family ADH_N PF08240.12 EFC46054.1 - 3.2e-10 39.9 0.0 1.6e-09 37.6 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFC46054.1 - 3.5e-10 41.0 0.0 1.1e-09 39.5 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC46054.1 - 2.8e-06 27.3 0.0 5.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFC46054.1 - 0.038 13.9 0.0 0.088 12.7 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase URO-D PF01208.17 EFC46054.1 - 0.096 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) MFS_1 PF07690.16 EFC46055.1 - 8.4e-11 41.4 47.2 2e-05 23.7 19.4 3.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1129 PF06570.11 EFC46055.1 - 0.00095 18.7 3.8 0.00095 18.7 3.8 3.3 4 0 0 4 4 4 1 Protein of unknown function (DUF1129) Sec66 PF09802.9 EFC46055.1 - 0.081 12.5 0.2 0.2 11.2 0.2 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DUF1980 PF09323.10 EFC46055.1 - 0.48 10.3 4.8 2.4 8.0 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) PBP1_TM PF14812.6 EFC46055.1 - 0.49 10.8 2.0 46 4.5 0.0 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ELH PF02323.15 EFC46055.1 - 0.67 9.3 7.6 0.37 10.1 2.7 2.2 2 0 0 2 2 2 0 Egg-laying hormone precursor EphA2_TM PF14575.6 EFC46055.1 - 1.4 9.8 3.1 6.2 7.8 0.4 3.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain MFS_2 PF13347.6 EFC46056.1 - 8.4e-118 393.6 21.0 8.4e-118 393.6 21.0 2.0 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.16 EFC46056.1 - 2.4e-08 33.3 17.1 2.4e-08 33.3 17.1 2.7 2 2 1 3 3 3 1 Major Facilitator Superfamily m04gp34like PF12216.8 EFC46056.1 - 0.013 15.1 0.2 0.35 10.4 0.0 2.2 2 0 0 2 2 2 0 Immune evasion protein RGS PF00615.19 EFC46059.1 - 7.4e-10 39.1 2.9 1.1e-08 35.3 2.9 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain EBP PF05241.12 EFC46060.1 - 9e-43 145.8 12.0 1.1e-42 145.5 12.0 1.0 1 0 0 1 1 1 1 Emopamil binding protein WD40 PF00400.32 EFC46061.1 - 5.9e-05 23.7 16.4 0.1 13.5 0.2 4.9 4 1 0 4 4 4 3 WD domain, G-beta repeat SulA PF03846.14 EFC46061.1 - 0.064 13.2 0.3 8.1 6.4 0.0 2.6 2 0 0 2 2 2 0 Cell division inhibitor SulA BTB PF00651.31 EFC46062.1 - 4e-11 43.1 1.9 1.1e-09 38.5 0.4 3.3 2 1 1 3 3 3 1 BTB/POZ domain SF-assemblin PF06705.11 EFC46062.1 - 0.0054 16.1 7.2 0.0054 16.1 7.2 2.7 4 0 0 4 4 4 1 SF-assemblin/beta giardin DUF5333 PF17267.2 EFC46062.1 - 0.0059 16.8 0.1 1.7 8.9 0.0 2.7 2 0 0 2 2 2 1 Family of unknown function (DUF5333) PLN_propep PF16485.5 EFC46062.1 - 0.0069 16.1 0.1 0.13 12.0 0.0 2.7 2 0 0 2 2 2 1 Protealysin propeptide GST_C_2 PF13410.6 EFC46062.1 - 0.014 15.4 0.0 0.059 13.4 0.0 2.1 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Apolipoprotein PF01442.18 EFC46062.1 - 0.018 14.9 0.5 0.038 13.9 0.5 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain FliG_M PF14841.6 EFC46062.1 - 0.055 13.7 1.9 0.34 11.2 0.1 2.9 2 2 0 2 2 2 0 FliG middle domain Guanylate_cyc PF00211.20 EFC46063.1 - 1.1e-25 90.4 2.2 4.3e-12 46.0 0.1 2.5 1 1 1 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC46063.1 - 1.5e-10 41.2 0.0 5.9e-10 39.3 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC46063.1 - 7.7e-06 25.9 0.1 0.0001 22.3 0.0 2.5 2 0 0 2 2 2 1 PAS fold HNOBA PF07701.14 EFC46063.1 - 0.0027 17.2 0.4 0.0065 15.9 0.4 1.6 1 0 0 1 1 1 1 Heme NO binding associated Orai-1 PF07856.12 EFC46063.1 - 0.16 11.6 0.1 0.16 11.6 0.1 3.6 5 0 0 5 5 5 0 Mediator of CRAC channel activity Claudin_2 PF13903.6 EFC46063.1 - 1.8 8.2 10.1 2.8 7.7 0.1 3.7 3 1 0 3 3 3 0 PMP-22/EMP/MP20/Claudin tight junction Methyltransf_3 PF01596.17 EFC46064.1 - 1.9e-39 135.0 0.7 2.3e-39 134.8 0.7 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EFC46064.1 - 5.5e-12 46.6 0.0 7.2e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC46064.1 - 0.00025 21.7 0.0 0.00036 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC46064.1 - 0.0043 16.9 0.0 0.011 15.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EFC46064.1 - 0.024 14.3 0.1 0.037 13.7 0.0 1.4 2 0 0 2 2 2 0 Conserved hypothetical protein 95 PCMT PF01135.19 EFC46064.1 - 0.025 14.3 0.0 0.034 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 EFC46064.1 - 0.028 15.1 0.1 0.086 13.6 0.1 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 EFC46064.1 - 0.042 14.5 0.0 0.07 13.8 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain NHL PF01436.21 EFC46065.1 - 0.001 19.0 3.1 0.18 11.9 0.0 3.6 3 1 1 4 4 4 2 NHL repeat Arylesterase PF01731.20 EFC46065.1 - 0.063 13.5 0.9 25 5.2 0.0 3.1 3 0 0 3 3 3 0 Arylesterase dDENN PF03455.19 EFC46067.1 - 0.12 12.4 3.3 0.33 11.0 3.3 1.8 1 0 0 1 1 1 0 dDENN domain TMEM125 PF15109.6 EFC46068.1 - 0.17 12.3 0.7 0.43 10.9 0.7 1.7 1 0 0 1 1 1 0 TMEM125 protein family EF-hand_7 PF13499.6 EFC46069.1 - 7.2e-05 23.2 0.4 0.019 15.4 0.3 3.3 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC46069.1 - 0.00027 20.6 0.1 0.015 15.2 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain Shisa PF13908.6 EFC46069.1 - 0.0066 16.7 4.2 0.058 13.6 0.2 2.6 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator EF-hand_1 PF00036.32 EFC46069.1 - 0.013 14.9 0.0 0.23 11.1 0.1 2.6 2 0 0 2 2 2 0 EF hand Neur_chan_memb PF02932.16 EFC46069.1 - 0.38 10.8 5.7 0.18 11.8 1.8 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region AhpC-TSA PF00578.21 EFC46070.1 - 1.3e-34 118.8 0.0 1.7e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC46070.1 - 1.3e-15 57.4 0.0 1.7e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 EFC46070.1 - 8.6e-13 47.9 0.0 1.5e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Trs65 PF12735.7 EFC46072.1 - 0.00026 20.5 5.8 0.0056 16.1 0.0 2.9 2 1 1 3 3 3 2 TRAPP trafficking subunit Trs65 MRP-S26 PF14943.6 EFC46073.1 - 2.3e-05 24.4 16.8 2.3e-05 24.4 16.8 2.6 2 1 0 2 2 2 1 Mitochondrial ribosome subunit S26 N6_N4_Mtase PF01555.18 EFC46073.1 - 0.011 15.5 1.5 0.011 15.5 1.5 1.9 2 1 0 2 2 2 0 DNA methylase NPAT_C PF15712.5 EFC46073.1 - 3.9 6.0 19.4 0.0057 15.4 8.6 1.6 2 1 0 2 2 2 0 NPAT C terminus DRY_EERY PF09750.9 EFC46074.1 - 0.0094 16.2 1.4 0.012 15.9 1.4 1.1 1 0 0 1 1 1 1 Alternative splicing regulator RsfS PF02410.15 EFC46075.1 - 9.1e-24 83.8 0.0 1.9e-23 82.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation CDC45 PF02724.14 EFC46076.1 - 5.9e-43 147.1 9.2 5.9e-43 147.1 9.2 2.5 2 2 1 3 3 3 2 CDC45-like protein Fer2_3 PF13085.6 EFC46078.1 - 0.13 12.3 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain WBP-1 PF11669.8 EFC46078.1 - 0.46 11.1 2.7 1.1 9.9 0.2 3.0 3 1 1 4 4 4 0 WW domain-binding protein 1 GET2 PF08690.10 EFC46078.1 - 3.1 7.4 10.4 6.6 6.3 0.3 2.4 2 0 0 2 2 2 0 GET complex subunit GET2 Presenilin PF01080.17 EFC46078.1 - 4.4 6.0 5.4 15 4.3 5.4 1.8 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 EFC46078.1 - 4.6 7.5 6.7 0.64 10.3 1.9 2.0 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PHD PF00628.29 EFC46079.1 - 4e-16 58.6 31.1 3.7e-09 36.3 12.2 2.9 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.6 EFC46079.1 - 0.021 14.4 3.3 0.021 14.4 3.3 3.2 2 1 0 2 2 2 0 PHD-finger SSXT PF05030.12 EFC46079.1 - 0.027 14.1 0.8 0.066 12.8 0.3 1.9 2 0 0 2 2 2 0 SSXT protein (N-terminal region) CP12 PF02672.15 EFC46079.1 - 0.38 11.5 4.4 2.6 8.9 0.3 3.1 3 0 0 3 3 3 0 CP12 domain zf-RING_2 PF13639.6 EFC46079.1 - 3.1 8.2 25.7 4.9 7.6 9.0 2.8 1 1 1 2 2 2 0 Ring finger domain INTS5_C PF14838.6 EFC46080.1 - 9.4e-10 37.8 15.5 5.4e-07 28.6 0.1 3.7 2 2 1 3 3 3 2 Integrator complex subunit 5 C-terminus zf-C3HC4_2 PF13923.6 EFC46081.1 - 2.4e-08 33.7 15.7 2.9e-08 33.4 14.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 EFC46081.1 - 1.1e-07 31.7 3.8 2.2e-07 30.7 3.8 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein SAP PF02037.27 EFC46081.1 - 1.5e-07 31.0 0.0 2.6e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 SAP domain zf-RING_UBOX PF13445.6 EFC46081.1 - 4.2e-07 29.9 13.1 1.3e-05 25.2 7.6 2.7 2 0 0 2 2 2 2 RING-type zinc-finger zf-RING_2 PF13639.6 EFC46081.1 - 7.6e-07 29.4 14.0 1.4e-06 28.5 14.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 EFC46081.1 - 4.6e-06 26.4 11.2 8.2e-06 25.6 11.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC46081.1 - 0.00012 22.0 14.8 0.00053 19.9 15.2 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFC46081.1 - 0.00025 20.9 14.0 0.00025 20.9 14.0 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 EFC46081.1 - 0.00076 19.6 8.2 0.0017 18.5 8.2 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 EFC46081.1 - 0.0012 18.9 11.4 0.0079 16.3 11.7 2.2 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 EFC46081.1 - 0.0013 18.5 13.8 0.034 14.0 13.9 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFC46081.1 - 0.0022 18.3 9.2 0.0078 16.5 9.2 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Rtf2 PF04641.12 EFC46081.1 - 0.006 16.0 4.5 0.006 16.0 4.5 2.0 3 0 0 3 3 3 1 Rtf2 RING-finger zf-Nse PF11789.8 EFC46081.1 - 0.0079 16.0 10.4 0.023 14.5 10.4 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zn-C2H2_12 PF18112.1 EFC46081.1 - 0.025 15.0 4.9 0.37 11.3 0.4 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain zf-WRNIP1_ubi PF18279.1 EFC46081.1 - 0.071 13.8 0.9 4.4 8.2 0.1 2.6 2 0 0 2 2 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain RE_Eco29kI PF09517.10 EFC46081.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Eco29kI restriction endonuclease zf-P11 PF03854.14 EFC46081.1 - 1.2 8.9 10.8 17 5.2 10.8 2.5 1 1 0 1 1 1 0 P-11 zinc finger Mem_trans PF03547.18 EFC46081.1 - 2.2 6.6 3.4 0.51 8.7 0.3 1.5 2 0 0 2 2 2 0 Membrane transport protein zf-RING_4 PF14570.6 EFC46081.1 - 2.4 8.0 13.7 13 5.7 13.8 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain DUF5364 PF17322.2 EFC46082.1 - 0.12 12.7 5.2 2.6 8.3 5.2 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5364) DUF3449 PF11931.8 EFC46083.1 - 0.016 15.0 2.0 0.016 15.0 2.0 5.7 2 2 1 3 3 3 0 Domain of unknown function (DUF3449) DUF3408 PF11888.8 EFC46084.1 - 0.0021 18.2 4.3 0.0021 18.2 4.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3408) PMSI1 PF15322.6 EFC46084.1 - 0.03 13.8 5.2 0.035 13.6 5.2 1.1 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative TMEM214 PF10151.9 EFC46084.1 - 0.1 11.1 5.9 0.11 10.9 5.9 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator RR_TM4-6 PF06459.12 EFC46084.1 - 0.2 11.5 15.4 0.23 11.3 15.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_C37 PF05416.12 EFC46084.1 - 0.21 10.1 6.8 0.23 10.0 6.8 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase GAGA_bind PF06217.12 EFC46084.1 - 0.51 10.6 8.8 0.57 10.4 8.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2828 PF11443.8 EFC46084.1 - 0.73 7.9 8.7 0.83 7.7 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Menin PF05053.13 EFC46084.1 - 1.1 7.6 6.3 1.1 7.5 6.3 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 EFC46084.1 - 1.9 7.4 9.2 2.1 7.3 9.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 EFC46084.1 - 2.7 6.7 7.0 3.1 6.5 7.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CAC1F_C PF16885.5 EFC46084.1 - 3.2 7.3 12.2 4.1 7.0 12.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Tim54 PF11711.8 EFC46084.1 - 3.8 6.2 12.7 0.062 12.1 5.9 1.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 TMPIT PF07851.13 EFC46084.1 - 6.3 5.9 6.2 9 5.4 6.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein CENP-I PF07778.11 EFC46084.1 - 7.8 5.1 6.4 5 5.7 5.4 1.3 1 1 0 1 1 1 0 Mis6 Adaptin_binding PF10199.9 EFC46084.1 - 8.1 7.1 16.4 12 6.5 1.9 2.2 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 PPL5 PF18168.1 EFC46084.1 - 8.4 5.6 12.5 3.3 6.9 10.3 1.4 1 1 1 2 2 2 0 Prim-pol family 5 Ras PF00071.22 EFC46085.1 - 2.7e-38 131.1 1.4 3e-38 131.0 1.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46085.1 - 1.8e-31 108.8 0.3 2.4e-31 108.5 0.3 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46085.1 - 1.9e-20 73.0 0.3 2.1e-20 72.9 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC46085.1 - 1.1e-08 34.9 0.3 3e-07 30.2 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC46085.1 - 1.9e-07 31.2 0.1 2.9e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC46085.1 - 2.6e-06 26.9 0.9 2.9e-06 26.8 0.9 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFC46085.1 - 8.5e-05 22.1 0.4 0.00011 21.6 0.3 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 EFC46085.1 - 0.0014 18.4 0.4 0.0024 17.7 0.1 1.4 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein G-alpha PF00503.20 EFC46085.1 - 0.0077 15.4 3.9 0.013 14.7 2.3 2.0 1 1 1 2 2 2 1 G-protein alpha subunit AAA PF00004.29 EFC46085.1 - 0.033 14.6 0.0 0.15 12.5 0.0 1.9 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFC46085.1 - 0.07 12.6 0.0 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region WD40 PF00400.32 EFC46086.1 - 2.5e-67 221.2 29.2 8.1e-11 42.3 0.3 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC46086.1 - 2.9e-20 72.4 7.9 2.7e-05 24.4 0.0 5.5 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC46086.1 - 1.2e-08 35.1 0.0 0.00028 20.8 0.0 3.1 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFC46086.1 - 2.4e-08 33.3 3.1 0.13 11.2 0.0 4.9 2 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NLE PF08154.12 EFC46086.1 - 3.5e-08 33.9 0.4 6.9e-08 32.9 0.4 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 EFC46086.1 - 5.5e-07 28.6 3.0 0.066 11.8 0.3 4.5 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFC46086.1 - 0.0016 17.3 0.9 2.3 6.9 0.2 3.7 1 1 2 3 3 3 1 Nup133 N terminal like WD40_like PF17005.5 EFC46086.1 - 0.021 14.2 0.0 0.94 8.7 0.0 3.3 4 0 0 4 4 4 0 WD40-like domain DUF3047 PF11249.8 EFC46086.1 - 0.045 13.2 0.0 0.22 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3047) PD40 PF07676.12 EFC46086.1 - 0.13 12.2 0.0 27 4.9 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Asp_Arg_Hydrox PF05118.15 EFC46087.1 - 1.3e-32 112.9 0.0 2.2e-31 108.8 0.0 2.1 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase Guanylate_cyc_2 PF09778.9 EFC46087.1 - 0.056 12.8 1.0 0.091 12.1 0.3 1.9 1 1 1 2 2 2 0 Guanylylate cyclase F-box PF00646.33 EFC46088.1 - 2.3e-05 24.2 0.1 4.1e-05 23.3 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC46088.1 - 0.00047 20.0 0.2 0.00075 19.3 0.2 1.4 1 0 0 1 1 1 1 F-box-like AFG1_ATPase PF03969.16 EFC46089.1 - 5.1e-97 325.0 0.8 1e-92 310.8 0.0 2.7 1 1 1 2 2 2 2 AFG1-like ATPase Bac_DnaA PF00308.18 EFC46089.1 - 1.1e-06 28.6 0.3 0.002 18.0 0.0 2.4 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_16 PF13191.6 EFC46089.1 - 0.00017 22.0 0.0 0.0029 18.0 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain UvrD-helicase PF00580.21 EFC46089.1 - 0.0007 19.2 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_14 PF13173.6 EFC46089.1 - 0.00071 19.6 0.0 0.0031 17.6 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC46089.1 - 0.0014 18.9 0.0 0.0057 16.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EFC46089.1 - 0.003 17.5 1.1 0.031 14.2 0.0 2.9 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA PF00004.29 EFC46089.1 - 0.0055 17.1 0.0 0.14 12.6 0.0 3.0 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFC46089.1 - 0.013 15.5 0.0 3.3 7.6 0.0 2.7 2 0 0 2 2 2 0 NACHT domain TUDOR PF00567.24 EFC46089.1 - 0.053 13.6 0.0 3.7 7.6 0.0 2.5 2 0 0 2 2 2 0 Tudor domain RNA_helicase PF00910.22 EFC46089.1 - 0.65 10.4 3.5 1.1 9.7 0.1 2.9 2 1 0 2 2 2 0 RNA helicase RCC1 PF00415.18 EFC46090.1 - 6.4e-21 74.7 0.2 1.5e-09 38.4 0.0 2.7 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46090.1 - 2.4e-13 49.5 10.3 2.9e-08 33.3 0.5 3.6 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat LRR_8 PF13855.6 EFC46090.1 - 5.3e-07 29.3 9.8 0.00035 20.3 1.9 4.2 3 0 0 3 3 3 2 Leucine rich repeat SAP PF02037.27 EFC46090.1 - 0.0022 17.7 4.0 0.014 15.1 0.0 3.8 4 0 0 4 4 4 1 SAP domain LRR_4 PF12799.7 EFC46090.1 - 0.01 16.3 0.3 0.01 16.3 0.3 6.2 3 1 4 7 7 7 0 Leucine Rich repeats (2 copies) EPO_TPO PF00758.18 EFC46090.1 - 0.19 11.7 3.9 0.19 11.7 0.6 2.8 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin ABC1 PF03109.16 EFC46091.1 - 1.3e-32 112.5 0.0 2.9e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 ABC1 family Plant_NMP1 PF06694.11 EFC46091.1 - 0.089 11.9 1.0 2.8 7.0 0.1 2.2 1 1 0 2 2 2 0 Plant nuclear matrix protein 1 (NMP1) HA2 PF04408.23 EFC46092.1 - 2.8e-22 79.0 0.5 6.8e-22 77.8 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFC46092.1 - 1e-17 64.2 0.0 2.3e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFC46092.1 - 3.3e-16 59.6 0.0 1.6e-15 57.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC46092.1 - 0.00081 19.2 1.1 0.0021 17.9 0.1 2.2 3 0 0 3 3 3 1 DEAD/DEAH box helicase Dynein_light PF01221.18 EFC46093.1 - 1.3e-27 96.0 0.1 1.4e-27 95.8 0.1 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 Ground-like PF04155.18 EFC46093.1 - 0.021 15.5 0.0 0.032 14.9 0.0 1.4 1 0 0 1 1 1 0 Ground-like domain DUF2294 PF10057.9 EFC46093.1 - 0.033 14.3 0.0 0.037 14.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2294) WD40 PF00400.32 EFC46094.1 - 0.0037 18.1 3.6 0.44 11.5 0.1 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat XPG_I_2 PF12813.7 EFC46094.1 - 0.0095 15.4 0.1 0.017 14.6 0.1 1.3 1 0 0 1 1 1 1 XPG domain containing eIF3_subunit PF08597.10 EFC46094.1 - 0.058 13.3 6.0 0.022 14.7 3.4 1.6 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit PBP1_TM PF14812.6 EFC46094.1 - 0.16 12.3 2.6 0.38 11.2 2.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PKD_channel PF08016.12 EFC46095.1 - 1.6e-09 37.0 13.0 1.6e-09 37.0 13.0 1.7 2 0 0 2 2 2 1 Polycystin cation channel cobW PF02492.19 EFC46097.1 - 1.2e-52 178.1 3.7 2.4e-50 170.6 3.7 2.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFC46097.1 - 4.1e-25 87.5 0.0 7.9e-25 86.6 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain ATPase_2 PF01637.18 EFC46097.1 - 0.00062 19.8 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 EFC46097.1 - 0.0024 17.8 0.3 3 7.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 EFC46097.1 - 0.0091 16.3 0.2 0.07 13.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 EFC46097.1 - 0.01 15.7 0.1 0.023 14.6 0.1 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B T2SSE PF00437.20 EFC46097.1 - 0.022 13.8 0.4 0.059 12.4 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein TsaE PF02367.17 EFC46097.1 - 0.022 14.8 0.0 0.045 13.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EFC46097.1 - 0.29 11.6 2.5 0.4 11.2 0.1 2.3 2 1 0 3 3 3 0 ABC transporter MKRN1_C PF15815.5 EFC46098.1 - 0.02 15.3 0.2 0.058 13.8 0.2 1.8 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase makorin-1, C-terminal GIT_CC PF16559.5 EFC46098.1 - 0.038 13.9 1.2 1.4 8.9 0.1 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PIP5K PF01504.18 EFC46098.1 - 0.18 11.0 3.2 1.4 8.0 0.2 2.9 2 1 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF3867 PF12983.7 EFC46099.1 - 0.007 16.4 2.5 0.011 15.7 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3867) YtzH PF14165.6 EFC46099.1 - 0.007 16.7 2.9 0.013 15.9 1.9 2.0 1 1 0 1 1 1 1 YtzH-like protein Nrf1_DNA-bind PF10491.9 EFC46099.1 - 0.023 14.4 0.1 0.039 13.7 0.1 1.4 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 TnpV PF14198.6 EFC46099.1 - 0.027 14.5 1.7 0.067 13.2 1.7 1.7 1 0 0 1 1 1 0 Transposon-encoded protein TnpV DUF3802 PF12290.8 EFC46099.1 - 0.073 13.6 2.0 0.15 12.6 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) DUF86 PF01934.17 EFC46099.1 - 0.096 12.6 2.7 0.13 12.2 0.9 2.1 3 0 0 3 3 3 0 Protein of unknown function DUF86 DUF4355 PF14265.6 EFC46099.1 - 4.1 7.6 14.8 2.4 8.4 12.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4355) TRAPP PF04051.16 EFC46101.1 - 4.9e-41 139.9 0.2 5.4e-41 139.7 0.2 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component XylR_N PF06505.11 EFC46101.1 - 0.0025 17.5 0.0 0.022 14.5 0.0 2.1 2 0 0 2 2 2 1 Activator of aromatic catabolism DUF3791 PF12668.7 EFC46101.1 - 0.083 13.0 0.1 0.31 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) DNTTIP1_dimer PF18192.1 EFC46101.1 - 0.089 13.2 0.4 0.22 11.9 0.1 1.8 2 0 0 2 2 2 0 DNTTIP1 dimerisation domain WD40 PF00400.32 EFC46102.1 - 0.067 14.1 10.6 25 5.9 0.2 5.7 4 1 0 4 4 4 0 WD domain, G-beta repeat Lgl_C PF08596.10 EFC46102.1 - 0.072 11.8 0.1 6.8 5.3 0.0 2.9 2 1 1 3 3 3 0 Lethal giant larvae(Lgl) like, C-terminal LRR_4 PF12799.7 EFC46103.1 - 1.2 9.6 10.8 9.3 6.8 0.1 4.5 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) His_Phos_1 PF00300.22 EFC46104.1 - 4.5e-11 42.8 0.0 5.4e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF5484 PF17583.2 EFC46104.1 - 0.069 12.8 0.3 0.12 12.1 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5484) Ndc1_Nup PF09531.10 EFC46105.1 - 0.022 13.4 3.8 0.025 13.3 3.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GSIII_N PF12437.8 EFC46105.1 - 0.028 14.1 0.5 0.028 14.1 0.5 1.7 2 0 0 2 2 2 0 Glutamine synthetase type III N terminal NAD_binding_5 PF07994.12 EFC46106.1 - 1.1e-138 462.0 0.1 1.3e-138 461.8 0.1 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 EFC46106.1 - 2e-46 156.7 0.1 2e-46 156.7 0.1 1.9 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase FA_desaturase PF00487.24 EFC46107.1 - 8.5e-08 32.3 13.1 3.4e-07 30.3 13.1 1.8 1 1 0 1 1 1 1 Fatty acid desaturase Atg14 PF10186.9 EFC46108.1 - 0.023 13.8 0.2 0.031 13.4 0.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Actin PF00022.19 EFC46109.1 - 9.1e-96 320.9 0.0 2.2e-94 316.4 0.0 2.0 1 1 0 1 1 1 1 Actin FtsA PF14450.6 EFC46109.1 - 0.019 15.3 0.0 0.045 14.2 0.0 1.7 1 1 0 1 1 1 0 Cell division protein FtsA RNF220 PF15926.5 EFC46111.1 - 0.48 10.0 3.2 0.23 11.1 0.2 1.9 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 Acetyltransf_9 PF13527.7 EFC46113.1 - 0.027 14.6 0.0 0.25 11.4 0.0 2.4 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain LPG_synthase_TM PF03706.13 EFC46114.1 - 0.005 16.4 4.2 0.007 15.9 4.2 1.2 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region Frizzled PF01534.17 EFC46114.1 - 0.54 9.2 6.4 0.81 8.7 6.4 1.3 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region DUF2304 PF10066.9 EFC46114.1 - 0.87 9.8 16.6 0.39 10.9 1.9 3.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2304) Claudin_3 PF06653.11 EFC46114.1 - 5.2 7.0 13.5 4.3 7.3 10.9 2.0 1 1 1 2 2 2 0 Tight junction protein, Claudin-like MORN_2 PF07661.13 EFC46116.1 - 4.8e-06 26.2 20.2 0.027 14.7 0.0 7.2 7 1 2 9 9 9 2 MORN repeat variant MORN PF02493.20 EFC46116.1 - 0.0019 18.0 17.6 2 8.5 0.1 5.5 5 0 0 5 5 5 3 MORN repeat F-box_5 PF18511.1 EFC46116.1 - 0.0043 16.6 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 F-box F-box PF00646.33 EFC46116.1 - 0.045 13.7 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC46116.1 - 0.058 13.3 0.1 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 F-box-like Sel1 PF08238.12 EFC46117.1 - 3.8e-64 211.7 25.4 5.2e-10 39.7 0.3 7.4 7 0 0 7 7 7 7 Sel1 repeat TPR_6 PF13174.6 EFC46117.1 - 1.1e-05 25.7 2.6 0.83 10.4 0.1 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46117.1 - 0.0003 21.0 8.4 33 5.2 0.2 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_20 PF14561.6 EFC46117.1 - 0.034 14.5 1.8 3.5 8.0 0.1 3.8 1 1 2 3 3 3 0 Tetratricopeptide repeat nec1 PF10379.9 EFC46117.1 - 0.04 13.4 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Virulence protein nec1 FapA PF03961.13 EFC46117.1 - 0.23 10.0 7.6 0.37 9.3 7.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DIT1_PvcA PF05141.12 EFC46117.1 - 0.52 9.7 6.1 2.6 7.4 6.5 1.9 1 1 1 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein Endotoxin_N PF03945.14 EFC46117.1 - 1.1 9.0 6.8 0.74 9.5 2.3 2.5 2 0 0 2 2 2 0 delta endotoxin, N-terminal domain UPF0242 PF06785.11 EFC46117.1 - 2.5 8.2 15.5 6.6 6.8 15.5 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus IL11 PF07400.11 EFC46117.1 - 4 7.1 6.9 12 5.5 0.0 4.0 3 2 2 5 5 5 0 Interleukin 11 Aconitase PF00330.20 EFC46119.1 - 1.4e-153 512.2 0.1 1.9e-153 511.8 0.1 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFC46119.1 - 1e-43 148.8 0.0 2.1e-43 147.8 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 EFC46119.1 - 0.066 11.9 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Oxysterol_BP PF01237.18 EFC46120.1 - 9.9e-84 281.3 3.1 2e-81 273.7 3.1 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein DUF4116 PF13475.6 EFC46122.1 - 5.1e-147 477.5 13.9 3.3e-17 62.0 0.1 8.0 1 1 11 12 12 12 12 Domain of unknown function (DUF4116) DUF3089 PF11288.8 EFC46122.1 - 0.04 13.5 0.4 1 8.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3089) GST_C PF00043.25 EFC46122.1 - 0.049 13.8 8.3 5.5 7.3 0.1 4.6 2 2 1 3 3 3 0 Glutathione S-transferase, C-terminal domain DUF4853 PF16145.5 EFC46122.1 - 0.091 12.9 0.1 2.6 8.2 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4853) PHZA_PHZB PF03284.13 EFC46122.1 - 0.11 12.1 0.2 5.5 6.6 0.1 2.5 2 0 0 2 2 2 0 Phenazine biosynthesis protein A/B DUF1667 PF07892.11 EFC46122.1 - 0.16 12.0 3.7 8 6.6 0.0 4.7 4 1 3 7 7 7 0 Protein of unknown function (DUF1667) DUF3606 PF12244.8 EFC46122.1 - 0.16 11.9 1.7 18 5.4 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3606) CdhD PF03599.16 EFC46122.1 - 0.18 10.4 15.9 0.33 9.6 1.1 4.0 1 1 3 4 4 4 0 CO dehydrogenase/acetyl-CoA synthase delta subunit PAS_6 PF08348.11 EFC46122.1 - 0.86 9.5 5.8 0.53 10.2 0.7 2.9 3 1 0 3 3 3 0 YheO-like PAS domain Mannitol_dh PF01232.23 EFC46122.1 - 1.7 8.8 10.3 17 5.5 0.4 4.0 3 1 1 4 4 4 0 Mannitol dehydrogenase Rossmann domain AidB_N PF18158.1 EFC46123.1 - 4.1e-25 88.5 0.0 7.4e-25 87.7 0.0 1.4 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFC46123.1 - 1.7e-21 77.0 0.3 5.5e-21 75.4 0.1 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFC46123.1 - 3.5e-13 49.5 0.1 6.6e-13 48.7 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFC46123.1 - 0.00024 21.4 0.0 0.00081 19.7 0.0 2.0 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HD PF01966.22 EFC46124.1 - 0.00032 20.9 2.2 0.00032 20.9 2.2 1.9 2 1 0 2 2 2 1 HD domain E3_UbLigase_EDD PF11547.8 EFC46124.1 - 0.042 13.5 1.5 0.047 13.4 0.4 1.6 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD Ribosomal_L9_N PF01281.19 EFC46125.1 - 1.6e-16 59.5 0.4 2.8e-16 58.8 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Cytadhesin_P30 PF07271.11 EFC46125.1 - 0.72 9.4 2.2 0.61 9.6 2.2 1.2 1 0 0 1 1 1 0 Cytadhesin P30/P32 Aminotran_4 PF01063.19 EFC46126.1 - 1.2e-29 103.8 0.0 1.5e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV AMP-binding PF00501.28 EFC46127.1 - 1.2e-80 271.2 0.0 1.6e-80 270.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Nop52 PF05997.12 EFC46128.1 - 4.3e-46 157.4 3.7 4.3e-46 157.4 3.7 3.5 2 1 1 3 3 3 1 Nucleolar protein,Nop52 PAC3 PF10178.9 EFC46129.1 - 0.0023 18.0 0.2 0.5 10.5 0.2 3.2 1 1 0 1 1 1 1 Proteasome assembly chaperone 3 WH1 PF00568.23 EFC46130.1 - 1.1e-10 41.4 1.1 1.7e-10 40.8 1.1 1.3 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 EFC46130.1 - 0.0011 19.3 0.4 0.0011 19.3 0.4 2.7 3 1 0 3 3 3 1 P21-Rho-binding domain Cadherin_C_2 PF16492.5 EFC46131.1 - 0.034 14.9 3.3 0.046 14.5 0.2 2.6 2 1 1 3 3 3 0 Cadherin cytoplasmic C-terminal Pkinase PF00069.25 EFC46131.1 - 0.036 13.4 0.1 0.094 12.1 0.1 1.7 1 0 0 1 1 1 0 Protein kinase domain FeoB_associated PF12669.7 EFC46131.1 - 0.052 14.0 0.9 0.11 12.9 0.9 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein 2OG-FeII_Oxy_3 PF13640.6 EFC46132.1 - 2.9e-05 24.9 0.1 6.9e-05 23.7 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SIN1_PH PF16979.5 EFC46133.1 - 0.00043 20.5 0.1 0.00085 19.6 0.1 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology CRIM PF16978.5 EFC46133.1 - 0.0017 18.5 0.0 0.0035 17.5 0.0 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain Cobl PF09469.10 EFC46133.1 - 0.067 13.5 0.1 0.18 12.1 0.1 1.7 1 0 0 1 1 1 0 Cordon-bleu ubiquitin-like domain Myosin_TH1 PF06017.13 EFC46133.1 - 0.11 12.2 0.6 0.3 10.7 0.1 1.8 2 0 0 2 2 2 0 Unconventional myosin tail, actin- and lipid-binding FKBP_C PF00254.28 EFC46134.1 - 6.7e-16 58.4 0.0 9e-16 58.0 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase AMMECR1 PF01871.17 EFC46135.1 - 5.6e-09 35.8 0.0 9.3e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 AMMECR1 Abhydrolase_3 PF07859.13 EFC46137.1 - 5.4e-42 144.0 0.0 7.4e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 EFC46137.1 - 4.6e-11 42.3 0.5 2.3e-10 40.0 0.5 1.9 1 1 0 1 1 1 1 Carboxylesterase family Chlorophyllase2 PF12740.7 EFC46137.1 - 1.4e-10 40.5 0.0 2.1e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 EFC46137.1 - 5.7e-07 28.8 0.0 4.7e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 Chlorophyllase Say1_Mug180 PF10340.9 EFC46137.1 - 1.6e-05 24.0 0.2 9e-05 21.5 0.2 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase PAF-AH_p_II PF03403.13 EFC46137.1 - 0.00033 19.3 0.0 0.0006 18.4 0.0 1.4 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Glyoxalase_6 PF18029.1 EFC46137.1 - 0.12 13.2 0.2 5.2 7.9 0.2 2.4 1 1 0 1 1 1 0 Glyoxalase-like domain Esterase PF00756.20 EFC46137.1 - 0.12 12.0 0.2 0.65 9.6 0.2 2.0 1 1 0 1 1 1 0 Putative esterase PTH2 PF01981.16 EFC46138.1 - 1.2e-42 144.9 0.4 1.3e-42 144.8 0.4 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Rsm22 PF09243.10 EFC46138.1 - 0.013 14.7 0.0 0.021 14.1 0.0 1.2 1 1 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 Oxidored_FMN PF00724.20 EFC46139.1 - 1.2e-76 258.3 0.0 1.4e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 EFC46139.1 - 0.0012 18.0 0.0 0.0033 16.6 0.0 1.7 2 1 0 2 2 2 1 Dihydrouridine synthase (Dus) HMGL-like PF00682.19 EFC46139.1 - 0.052 13.1 0.0 0.53 9.8 0.0 2.3 1 1 1 2 2 2 0 HMGL-like MMS19_N PF14500.6 EFC46140.1 - 3.1e-73 246.6 1.2 2.3e-72 243.7 0.1 2.9 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 EFC46140.1 - 2.8e-44 151.9 16.1 1.1e-43 149.9 10.1 3.4 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 EFC46140.1 - 0.004 17.6 0.3 0.72 10.4 0.0 4.2 4 0 0 4 4 4 1 HEAT-like repeat TetR_C_19 PF17924.1 EFC46140.1 - 0.0049 17.4 0.5 0.21 12.2 0.0 3.5 3 0 0 3 3 3 1 Tetracyclin repressor-like, C-terminal domain HEAT PF02985.22 EFC46140.1 - 0.015 15.5 0.1 2.3 8.7 0.0 4.1 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 EFC46140.1 - 0.04 14.3 0.0 0.71 10.3 0.0 2.7 2 0 0 2 2 2 0 HEAT repeats Vac14_Fab1_bd PF12755.7 EFC46140.1 - 0.21 12.2 2.6 0.74 10.4 0.2 3.3 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region GBP PF02263.19 EFC46141.1 - 7.6e-33 113.9 0.1 7.6e-33 113.9 0.1 3.2 3 1 0 3 3 3 1 Guanylate-binding protein, N-terminal domain GBP_C PF02841.14 EFC46141.1 - 1.2e-10 41.3 26.1 1.9e-10 40.6 26.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain Adhesin_P1_N PF18652.1 EFC46141.1 - 0.022 14.8 0.9 0.078 13.0 0.9 1.9 1 0 0 1 1 1 0 Adhesin P1 N-terminal domain SPX PF03105.19 EFC46142.1 - 2.3 8.0 9.3 2.8 7.8 9.3 1.3 1 0 0 1 1 1 0 SPX domain COG7 PF10191.9 EFC46143.1 - 9.6e-13 47.3 25.0 2.1e-11 42.8 24.8 2.6 1 1 0 1 1 1 1 Golgi complex component 7 (COG7) DUF1729 PF08354.10 EFC46143.1 - 0.1 11.5 4.0 0.033 13.1 1.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1729) Nup54 PF13874.6 EFC46143.1 - 2.4 8.2 5.8 1.5 8.9 2.3 2.3 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Acyltransferase PF01553.21 EFC46144.1 - 4.8e-11 42.4 0.0 8.8e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase FKBP_C PF00254.28 EFC46146.1 - 7e-34 116.0 0.0 8.9e-34 115.7 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RimK PF08443.11 EFC46147.1 - 8.8e-07 28.7 0.2 0.0083 15.7 0.0 2.7 3 0 0 3 3 3 2 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 EFC46147.1 - 0.0027 17.0 0.1 0.037 13.3 0.1 2.6 2 1 0 2 2 2 1 Sugar-transfer associated ATP-grasp F-box PF00646.33 EFC46147.1 - 0.033 14.1 0.0 0.087 12.7 0.0 1.7 1 0 0 1 1 1 0 F-box domain Glycos_transf_1 PF00534.20 EFC46148.1 - 5.3e-27 94.4 0.1 9.3e-27 93.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFC46148.1 - 1.3e-14 54.5 0.0 4e-14 53.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 EFC46148.1 - 3.7e-11 43.6 0.0 6.6e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFC46148.1 - 0.012 16.0 0.0 0.037 14.4 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFC46148.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain IMCp PF12314.8 EFC46148.1 - 1.6 9.1 5.1 2.2 8.6 0.4 2.3 2 0 0 2 2 2 0 Inner membrane complex protein DUF1647 PF07801.11 EFC46150.1 - 0.034 13.9 0.1 0.043 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) RGS PF00615.19 EFC46151.1 - 0.015 15.6 1.4 0.023 15.0 0.2 2.0 2 1 0 2 2 2 0 Regulator of G protein signaling domain RGS PF00615.19 EFC46152.1 - 2.1e-05 24.8 0.3 5.4e-05 23.4 0.3 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ribosomal_S25 PF03297.15 EFC46152.1 - 0.022 15.0 0.0 0.05 13.8 0.0 1.5 1 0 0 1 1 1 0 S25 ribosomal protein FA_desaturase PF00487.24 EFC46153.1 - 1.5e-19 70.8 18.5 1.1e-10 41.8 2.6 2.6 2 1 1 3 3 3 2 Fatty acid desaturase DUF3474 PF11960.8 EFC46153.1 - 2.4e-06 27.8 0.0 7.2e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3474) DUF4525 PF15027.6 EFC46154.1 - 7.9 6.2 8.0 1.2 8.9 2.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4525) EF-hand_1 PF00036.32 EFC46155.1 - 3.8e-15 54.2 3.7 1.5e-05 24.2 0.2 3.7 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC46155.1 - 7.6e-15 55.1 5.1 7.4e-11 42.3 0.4 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC46155.1 - 3.2e-11 42.2 3.0 0.012 15.5 0.0 3.7 3 1 0 3 3 3 3 EF-hand domain EF-hand_8 PF13833.6 EFC46155.1 - 1e-07 31.6 6.1 0.0019 18.0 0.9 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC46155.1 - 8.6e-05 21.9 2.9 0.099 12.2 0.2 4.1 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 EFC46155.1 - 0.005 17.1 2.4 0.0053 17.1 0.5 1.9 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 EFC46155.1 - 0.0096 15.8 3.7 0.36 10.7 0.1 2.6 3 0 0 3 3 3 2 EF hand EF-hand_4 PF12763.7 EFC46155.1 - 0.21 11.5 2.3 7.5 6.6 0.1 2.4 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.25 EFC46156.1 - 1e-44 152.9 0.0 8.9e-41 140.0 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46156.1 - 7.1e-33 114.0 0.0 1.1e-30 106.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DUF1492 PF07374.11 EFC46156.1 - 0.15 12.2 0.5 6.3 7.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) APH PF01636.23 EFC46156.1 - 0.18 11.7 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RGS PF00615.19 EFC46157.1 - 2.5e-05 24.5 3.5 5.6e-05 23.4 3.5 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF2700 PF10912.8 EFC46157.1 - 0.0047 17.0 1.5 0.16 12.0 0.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2700) Enkurin PF13864.6 EFC46157.1 - 0.041 14.3 4.2 0.32 11.4 0.3 2.5 2 0 0 2 2 2 0 Calmodulin-binding Jak1_Phl PF17887.1 EFC46157.1 - 3.7 7.5 7.1 0.16 11.9 0.5 2.1 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Peptidase_C1 PF00112.23 EFC46160.1 - 3.8e-58 197.2 6.5 4.5e-58 196.9 6.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC46160.1 - 4.8e-05 22.3 2.5 0.091 11.5 0.6 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC46160.1 - 6.5e-05 22.7 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase family C1 propeptide Fig1 PF12351.8 EFC46161.1 - 2.8 7.8 14.3 0.042 13.8 5.7 2.0 1 1 1 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Glyco_hydro_2_C PF02836.17 EFC46162.1 - 0.00037 19.7 0.0 0.0006 19.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain ubiquitin PF00240.23 EFC46164.1 - 5.4e-63 208.7 7.1 5.3e-32 109.4 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC46164.1 - 3.2e-29 100.5 7.8 3.6e-15 55.6 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC46164.1 - 6.6e-10 39.3 4.5 0.00027 21.3 0.8 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC46164.1 - 7.8e-09 35.6 0.4 0.0021 18.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC46164.1 - 7.9e-09 35.3 0.6 0.0022 17.9 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFC46164.1 - 8.4e-08 32.7 0.1 0.0022 18.6 0.0 2.2 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC46164.1 - 1.6e-07 31.6 2.3 0.0075 16.6 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC46164.1 - 9e-05 22.4 8.1 3.7 7.7 0.2 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain DUF3861 PF12977.7 EFC46164.1 - 0.024 14.8 0.3 2.4 8.4 0.0 2.4 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) PI3K_p85B PF02192.16 EFC46164.1 - 0.028 14.2 0.7 2.3 8.0 0.1 2.4 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain PilN_bio_d PF18222.1 EFC46164.1 - 0.072 13.5 0.1 2.8 8.4 0.0 2.1 2 0 0 2 2 2 0 PilN biogenesis protein dimerization domain bPH_3 PF14470.6 EFC46164.1 - 0.18 12.2 2.0 4.7 7.6 0.3 2.9 3 0 0 3 3 3 0 Bacterial PH domain NHL PF01436.21 EFC46165.1 - 1.5e-59 195.2 0.1 1.9e-05 24.5 0.0 12.0 12 0 0 12 12 12 10 NHL repeat REJ PF02010.15 EFC46165.1 - 5.7e-25 88.0 13.4 2.1e-22 79.5 6.5 2.7 2 0 0 2 2 2 2 REJ domain SGL PF08450.12 EFC46165.1 - 2.9e-14 53.3 8.0 2.3e-07 30.7 2.8 4.2 2 2 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC46165.1 - 2.2e-07 31.1 57.4 0.0011 19.3 8.7 5.2 5 0 0 5 5 5 3 EGF-like domain Arylesterase PF01731.20 EFC46165.1 - 2.9e-06 27.4 6.0 11 6.3 0.0 7.7 8 1 1 9 9 9 2 Arylesterase Phytase-like PF13449.6 EFC46165.1 - 0.00015 21.8 0.1 5.5 6.8 0.0 4.5 3 2 1 4 4 4 2 Esterase-like activity of phytase DUF839 PF05787.13 EFC46165.1 - 0.0087 15.3 7.8 0.64 9.1 0.3 3.3 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF839) DUF1382 PF07131.11 EFC46165.1 - 0.083 12.9 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1382) SBBP PF06739.11 EFC46165.1 - 0.96 9.5 12.9 28 4.8 0.1 6.6 7 0 0 7 7 7 0 Beta-propeller repeat HSP70 PF00012.20 EFC46166.1 - 3e-33 114.9 0.6 4e-33 114.5 0.6 1.1 1 0 0 1 1 1 1 Hsp70 protein LssY_C PF14067.6 EFC46166.1 - 0.02 14.4 0.1 0.039 13.5 0.1 1.4 1 0 0 1 1 1 0 LssY C-terminus ArAE_1_C PF11728.8 EFC46166.1 - 3.6 7.5 6.6 1.2 9.1 0.3 2.5 3 0 0 3 3 3 0 Putative aromatic acid exporter C-terminal domain LRR_6 PF13516.6 EFC46168.1 - 0.00026 20.8 9.4 3 8.1 0.1 7.0 5 1 1 6 6 6 2 Leucine Rich repeat F-box PF00646.33 EFC46168.1 - 0.0037 17.1 0.5 0.012 15.5 0.1 2.1 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC46168.1 - 0.018 14.9 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 F-box-like Menin PF05053.13 EFC46168.1 - 3.6 5.8 5.2 5.7 5.2 5.2 1.2 1 0 0 1 1 1 0 Menin DENN PF02141.21 EFC46169.1 - 1.3e-13 51.3 2.1 1.3e-13 51.3 2.1 4.2 4 1 1 5 5 5 2 DENN (AEX-3) domain uDENN PF03456.18 EFC46169.1 - 7.4e-05 23.4 2.1 0.013 16.2 0.8 3.9 3 0 0 3 3 3 1 uDENN domain DUF4252 PF14060.6 EFC46169.1 - 0.0014 18.5 4.1 0.0022 17.9 0.5 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4252) 2OG-FeII_Oxy_5 PF13759.6 EFC46169.1 - 0.12 12.9 0.4 15 6.1 0.1 2.8 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase Mrr_cat PF04471.12 EFC46170.1 - 1.8e-15 56.9 0.0 2.7e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease DUF2034 PF10356.9 EFC46170.1 - 5.5e-13 48.8 0.1 1.7e-07 30.9 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) SBF_like PF13593.6 EFC46170.1 - 0.068 12.5 0.1 0.085 12.2 0.1 1.1 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) dCache_1 PF02743.18 EFC46171.1 - 8.9e-11 42.0 1.0 3.9e-10 39.9 1.0 2.1 1 1 0 1 1 1 1 Cache domain Guanylate_cyc PF00211.20 EFC46171.1 - 3.9e-07 29.9 0.6 1e-06 28.5 0.6 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain KLRAQ PF10205.9 EFC46173.1 - 0.048 13.9 0.3 0.24 11.7 0.1 2.1 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein Sterile PF03015.19 EFC46173.1 - 1 9.7 5.5 0.79 10.0 0.8 2.9 2 1 0 2 2 2 0 Male sterility protein Ank_3 PF13606.6 EFC46174.1 - 3e-12 45.6 1.7 1 10.1 0.1 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 EFC46174.1 - 1.2e-09 38.5 1.4 0.21 12.2 0.0 5.8 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC46174.1 - 7.9e-09 35.6 0.3 0.47 11.0 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 EFC46174.1 - 9.5e-08 32.5 1.9 0.00015 22.2 2.9 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC46174.1 - 0.009 16.3 0.1 21 5.6 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeats (many copies) DUF4476 PF14771.6 EFC46174.1 - 0.029 14.7 0.2 0.066 13.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) TPR_1 PF00515.28 EFC46175.1 - 6.2e-52 171.4 36.2 4.8e-08 32.5 0.0 10.6 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46175.1 - 3.2e-41 136.1 30.4 5.9e-07 29.1 0.0 10.6 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46175.1 - 5.4e-34 113.5 25.2 5.7e-08 32.4 0.0 10.6 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 EFC46175.1 - 4.4e-26 91.2 0.0 3.2e-08 34.1 0.2 6.0 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFC46175.1 - 4.1e-25 86.3 0.6 0.025 15.4 0.0 8.4 3 3 6 9 9 9 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46175.1 - 5.6e-24 82.8 15.7 0.00017 21.8 0.0 10.4 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46175.1 - 4.7e-22 78.3 9.7 0.0021 18.5 1.4 6.6 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46175.1 - 4.2e-19 68.6 17.7 0.0019 18.5 0.2 7.6 4 3 2 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFC46175.1 - 5.5e-19 67.5 19.1 0.44 11.3 0.0 10.3 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFC46175.1 - 1e-18 66.7 28.0 4.8e-06 26.2 0.6 9.6 7 3 5 12 12 12 6 TPR repeat TPR_7 PF13176.6 EFC46175.1 - 8.3e-15 53.7 20.6 0.15 12.1 0.1 9.6 9 1 1 10 10 9 4 Tetratricopeptide repeat TPR_15 PF13429.6 EFC46175.1 - 2e-11 43.6 11.7 6.6e-05 22.2 0.7 4.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC46175.1 - 8.8e-09 35.4 3.0 0.021 14.9 1.3 5.8 2 2 4 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC46175.1 - 4.4e-07 30.0 10.4 6.3e-05 23.1 1.8 4.2 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFC46175.1 - 7.3e-05 22.5 5.2 26 4.8 0.2 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC46175.1 - 0.0005 19.6 3.7 1.1 8.6 0.1 3.5 2 2 2 4 4 4 2 MalT-like TPR region TPR_21 PF09976.9 EFC46175.1 - 0.00051 19.8 5.8 0.24 11.1 0.0 4.7 2 2 2 5 5 5 1 Tetratricopeptide repeat-like domain DUF2989 PF11207.8 EFC46175.1 - 0.0016 18.2 2.9 4.8 6.9 0.0 3.7 2 1 1 3 3 3 1 Protein of unknown function (DUF2989) DUF2225 PF09986.9 EFC46175.1 - 0.0025 17.6 10.0 0.081 12.6 0.4 4.7 2 2 2 4 4 4 1 Uncharacterized protein conserved in bacteria (DUF2225) BTAD PF03704.17 EFC46175.1 - 0.0046 17.4 2.8 1.6 9.1 0.1 3.0 3 0 0 3 3 3 1 Bacterial transcriptional activator domain SNAP PF14938.6 EFC46175.1 - 0.0055 16.2 13.8 0.081 12.3 1.7 4.5 1 1 3 4 4 4 2 Soluble NSF attachment protein, SNAP ChAPs PF09295.10 EFC46175.1 - 0.0055 15.8 0.6 0.7 8.8 0.0 3.1 3 0 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) RPN7 PF10602.9 EFC46175.1 - 4.1 7.1 14.4 32 4.2 1.1 4.8 5 1 0 5 5 5 0 26S proteasome subunit RPN7 DUF3209 PF11483.8 EFC46177.1 - 0.021 15.3 0.0 0.028 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3209) RGS PF00615.19 EFC46178.1 - 3.1e-18 66.1 6.1 3.1e-18 66.1 6.1 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Rnk_N PF14760.6 EFC46178.1 - 0.055 14.0 0.1 0.13 12.7 0.0 1.7 2 0 0 2 2 2 0 Rnk N-terminus LRR_6 PF13516.6 EFC46179.1 - 3.3e-25 86.0 0.3 0.017 15.1 0.0 7.0 7 1 0 7 7 7 6 Leucine Rich repeat LRR_8 PF13855.6 EFC46179.1 - 3.8e-17 61.8 4.6 4.3e-07 29.6 0.3 4.1 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC46179.1 - 1.6e-16 60.1 8.5 0.00036 20.8 0.1 5.3 1 1 6 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46179.1 - 1.2e-08 34.3 0.0 40 5.3 0.0 7.1 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC46179.1 - 1.1e-07 31.6 1.2 0.0089 15.5 0.1 2.7 2 1 1 3 3 3 2 Leucine-rich repeat DUF2097 PF09870.9 EFC46179.1 - 0.027 14.7 0.2 2.3 8.5 0.0 3.6 2 2 2 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2097) CLU_N PF15044.6 EFC46179.1 - 0.062 13.7 2.9 6.1 7.3 0.1 3.9 2 1 2 5 5 5 0 Mitochondrial function, CLU-N-term Beta_helix PF13229.6 EFC46179.1 - 0.11 12.4 2.5 4.8 7.0 1.5 2.3 1 1 1 2 2 2 0 Right handed beta helix region ApoB100_C PF12491.8 EFC46179.1 - 0.13 12.3 7.1 36 4.4 0.0 5.2 3 2 3 6 6 6 0 Apolipoprotein B100 C terminal AAA PF00004.29 EFC46180.1 - 9.2e-13 48.8 1.5 5.4e-12 46.3 0.1 2.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) DUF971 PF06155.12 EFC46180.1 - 1.8e-07 31.7 0.0 8.5e-07 29.5 0.0 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF971) AAA_14 PF13173.6 EFC46180.1 - 6.6e-07 29.4 0.0 5.8e-06 26.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 EFC46180.1 - 5.1e-05 23.3 0.1 0.0003 20.8 0.0 2.3 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 EFC46180.1 - 5.2e-05 23.1 0.0 9.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC46180.1 - 6.5e-05 23.0 0.0 0.00019 21.5 0.0 1.9 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC46180.1 - 8.8e-05 22.8 0.4 0.0089 16.3 0.0 3.7 3 1 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 EFC46180.1 - 0.00064 19.5 0.0 0.0023 17.7 0.0 1.9 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 EFC46180.1 - 0.0017 18.8 0.0 0.0059 17.0 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFC46180.1 - 0.0048 16.7 0.5 0.016 14.9 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFC46180.1 - 0.0087 16.6 0.0 0.055 14.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 EFC46180.1 - 0.011 15.9 0.0 0.03 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 EFC46180.1 - 0.021 14.6 1.4 4.8 6.9 0.0 3.0 2 1 1 3 3 2 0 DEAD/DEAH box helicase Zeta_toxin PF06414.12 EFC46180.1 - 0.031 13.6 0.0 0.081 12.2 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin ATPase PF06745.13 EFC46180.1 - 0.048 13.0 0.7 1.7 7.9 0.1 2.7 1 1 1 2 2 2 0 KaiC NACHT PF05729.12 EFC46180.1 - 0.049 13.5 0.4 0.95 9.4 0.0 2.7 3 0 0 3 3 3 0 NACHT domain ABC_tran PF00005.27 EFC46180.1 - 0.052 14.1 2.0 0.24 11.9 0.2 3.1 2 1 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 EFC46180.1 - 0.062 13.7 1.8 0.29 11.5 0.0 3.0 3 0 0 3 3 2 0 RNA helicase NTPase_1 PF03266.15 EFC46180.1 - 0.082 12.8 0.1 0.38 10.6 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_25 PF13481.6 EFC46180.1 - 0.14 11.7 0.2 0.61 9.6 0.1 2.0 1 1 0 2 2 2 0 AAA domain F-box-like PF12937.7 EFC46182.1 - 0.055 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 EFC46182.1 - 0.082 12.8 0.0 0.24 11.3 0.0 2.0 1 1 0 1 1 1 0 F-box domain TssO PF17561.2 EFC46183.1 - 0.0057 16.8 1.2 0.015 15.4 1.2 1.7 1 0 0 1 1 1 1 Type VI secretion system, TssO Atg8 PF02991.16 EFC46184.1 - 5.4e-47 158.3 0.3 6.3e-47 158.1 0.3 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 EFC46184.1 - 3.8e-08 33.6 0.1 4.8e-08 33.3 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Zn_clus PF00172.18 EFC46185.1 - 1e-08 35.1 12.2 3.1e-08 33.6 12.2 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA_32 PF13654.6 EFC46185.1 - 0.0068 15.3 0.1 0.013 14.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain His_kinase PF06580.13 EFC46185.1 - 0.19 12.1 2.6 0.33 11.3 0.5 2.6 2 0 0 2 2 2 0 Histidine kinase MMR_HSR1_Xtn PF16897.5 EFC46186.1 - 4.1e-39 132.8 1.5 1.3e-38 131.3 1.3 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 EFC46186.1 - 3.8e-23 81.3 0.1 6.8e-23 80.5 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 EFC46186.1 - 1.5e-22 79.9 0.0 4.1e-22 78.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC46186.1 - 8.9e-13 48.0 0.0 1.6e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC46186.1 - 6.8e-05 23.0 1.0 0.19 11.8 0.1 2.7 2 1 0 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 EFC46186.1 - 0.0027 17.6 0.5 0.11 12.4 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 EFC46186.1 - 0.0053 16.1 0.0 0.0097 15.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family SHMT PF00464.19 EFC46186.1 - 0.013 14.1 0.0 0.021 13.4 0.0 1.2 1 0 0 1 1 1 0 Serine hydroxymethyltransferase GTP_EFTU PF00009.27 EFC46186.1 - 0.019 14.5 0.4 5.7 6.4 0.0 3.3 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFC46186.1 - 0.046 12.7 0.2 0.14 11.1 0.1 1.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 EFC46186.1 - 0.063 13.8 0.1 0.2 12.2 0.1 1.8 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 EFC46186.1 - 0.077 13.4 0.1 0.78 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Pkinase PF00069.25 EFC46187.1 - 8.8e-60 202.3 0.8 2.6e-58 197.4 0.2 2.2 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46187.1 - 1.6e-35 122.6 0.0 2.5e-35 122.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC46187.1 - 3.2e-05 22.9 0.0 5.2e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC46187.1 - 0.0006 19.2 0.0 0.00096 18.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Jag_N PF14804.6 EFC46187.1 - 0.14 12.5 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Jag N-terminus Thioredoxin PF00085.20 EFC46189.1 - 9.9e-22 76.9 0.0 1.4e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EFC46189.1 - 3.2e-06 27.1 0.0 4e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 EFC46189.1 - 6.7e-06 26.3 0.0 0.0007 19.9 0.0 2.7 1 1 2 3 3 3 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFC46189.1 - 2.5e-05 24.7 0.0 7.5e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 EFC46189.1 - 0.00018 21.6 0.0 0.00041 20.5 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EFC46189.1 - 0.00022 21.0 0.0 0.00026 20.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 EFC46189.1 - 0.0044 17.0 0.0 0.007 16.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_6 PF13848.6 EFC46189.1 - 0.0049 16.8 0.0 0.0071 16.3 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EFC46189.1 - 0.0088 16.0 0.0 0.048 13.6 0.0 1.9 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC46189.1 - 0.029 14.1 0.0 0.079 12.7 0.0 1.7 1 1 0 1 1 1 0 Redoxin KaiB PF07689.12 EFC46189.1 - 0.073 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiB domain NifU_N PF01592.16 EFC46190.1 - 2.4e-50 170.0 0.3 3.3e-50 169.5 0.3 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain WD40 PF00400.32 EFC46191.1 - 6.1e-05 23.7 6.8 0.42 11.6 0.1 5.8 5 1 0 5 5 5 2 WD domain, G-beta repeat PDEase_I PF00233.19 EFC46192.1 - 3.2e-79 266.0 0.2 3.8e-79 265.8 0.2 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Terpene_synth PF01397.21 EFC46192.1 - 0.071 12.8 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain LRR_6 PF13516.6 EFC46193.1 - 1.9e-23 80.4 5.5 0.0012 18.7 0.0 7.2 8 0 0 8 8 8 6 Leucine Rich repeat LRR_8 PF13855.6 EFC46193.1 - 1.3e-20 72.9 7.8 4.6e-08 32.7 0.5 4.5 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC46193.1 - 9e-15 54.6 14.7 0.0012 19.1 0.1 5.7 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46193.1 - 8.4e-10 37.8 5.2 0.27 11.9 0.0 6.4 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC46193.1 - 3.4e-06 26.7 1.1 0.0023 17.5 0.1 2.3 1 1 1 2 2 2 2 Leucine-rich repeat Nitrophorin PF02087.15 EFC46193.1 - 0.14 12.1 0.4 1.9 8.4 0.0 2.6 2 1 1 3 3 3 0 Nitrophorin SF3A3 PF16837.5 EFC46193.1 - 0.15 12.6 0.8 31 5.2 0.1 3.1 1 1 2 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 RNA_pol_I_TF PF04090.12 EFC46193.1 - 0.18 11.3 4.1 2.5 7.6 0.2 3.1 2 2 0 3 3 3 0 RNA polymerase I specific initiation factor AAA_16 PF13191.6 EFC46194.1 - 2.5e-25 89.8 0.0 8.3e-25 88.1 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain Pkinase PF00069.25 EFC46194.1 - 3.8e-24 85.5 0.0 1.8e-23 83.2 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46194.1 - 3.8e-11 42.8 0.0 8.1e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC46194.1 - 0.00035 20.0 0.1 0.00073 18.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF815 PF05673.13 EFC46194.1 - 0.0014 17.8 0.1 0.053 12.7 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 EFC46194.1 - 0.0045 16.2 0.1 0.013 14.7 0.1 1.8 2 1 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 EFC46194.1 - 0.0082 16.1 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Choline_kinase PF01633.20 EFC46194.1 - 0.0088 15.6 1.2 0.013 15.0 0.1 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kinase-like PF14531.6 EFC46194.1 - 0.021 14.1 0.0 0.086 12.1 0.0 1.9 1 1 0 1 1 1 0 Kinase-like APH PF01636.23 EFC46194.1 - 0.028 14.3 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family TniB PF05621.11 EFC46194.1 - 0.038 13.4 0.0 0.08 12.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein RepA_N PF06970.11 EFC46194.1 - 0.098 12.6 0.0 0.33 10.9 0.0 1.9 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus Guanylate_cyc PF00211.20 EFC46195.1 - 3.1e-26 92.1 0.1 6.8e-26 91.0 0.1 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain SpoVT_C PF15714.5 EFC46195.1 - 0.016 15.2 0.0 0.048 13.7 0.0 1.7 1 0 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor GAF PF01590.26 EFC46195.1 - 0.053 14.2 0.0 0.098 13.3 0.0 1.4 1 0 0 1 1 1 0 GAF domain GAF_2 PF13185.6 EFC46195.1 - 0.15 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 GAF domain zf-RING_2 PF13639.6 EFC46196.1 - 2.4e-08 34.1 8.1 4.4e-08 33.3 8.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC46196.1 - 8.9e-07 28.7 9.8 1.9e-06 27.6 9.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC46196.1 - 5e-06 26.4 8.4 8.4e-06 25.6 8.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFC46196.1 - 8e-06 25.6 11.0 1.6e-05 24.7 11.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC46196.1 - 1e-05 25.2 2.6 1e-05 25.2 2.6 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 EFC46196.1 - 2e-05 24.4 6.0 3.7e-05 23.5 6.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC46196.1 - 6.4e-05 22.9 5.3 6.4e-05 22.9 5.3 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 EFC46196.1 - 8.2e-05 22.8 7.8 8.2e-05 22.8 7.8 2.2 2 1 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFC46196.1 - 0.00055 19.7 8.0 0.001 18.9 8.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Mucin PF01456.17 EFC46196.1 - 0.0017 18.3 1.5 0.0023 17.9 1.5 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein zf-ANAPC11 PF12861.7 EFC46196.1 - 0.012 15.6 1.4 0.029 14.4 1.4 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 EFC46196.1 - 0.016 15.1 1.9 0.031 14.1 1.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 EFC46196.1 - 0.081 12.8 5.1 0.17 11.7 5.1 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Zn_ribbon_17 PF17120.5 EFC46196.1 - 0.15 11.7 2.3 0.29 10.8 2.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 EFC46196.1 - 0.49 10.5 5.6 1.1 9.3 5.6 1.7 1 1 0 1 1 1 0 Zinc-finger FANCI_S2 PF14676.6 EFC46196.1 - 7.8 6.8 8.2 1.3 9.3 3.3 2.0 2 0 0 2 2 2 0 FANCI solenoid 2 CCDC53 PF10152.9 EFC46197.1 - 3.1e-27 95.9 14.7 1.3e-26 93.8 10.0 2.9 2 1 0 2 2 2 1 Subunit CCDC53 of WASH complex CC2-LZ PF16516.5 EFC46197.1 - 0.02 15.2 0.3 0.04 14.3 0.3 1.5 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Drf_FH1 PF06346.12 EFC46197.1 - 0.029 14.1 73.9 0.17 11.6 74.1 1.9 1 1 0 1 1 1 0 Formin Homology Region 1 Laminin_II PF06009.12 EFC46197.1 - 0.082 12.9 0.2 0.17 11.9 0.2 1.6 1 0 0 1 1 1 0 Laminin Domain II TMF_TATA_bd PF12325.8 EFC46197.1 - 0.15 12.3 1.9 0.5 10.6 1.9 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FAD_binding_8 PF08022.12 EFC46199.1 - 0.0086 16.1 0.1 0.021 14.9 0.1 1.6 1 0 0 1 1 1 1 FAD-binding domain DUF3050 PF11251.8 EFC46199.1 - 0.037 13.7 0.1 0.086 12.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3050) NCA2 PF08637.10 EFC46200.1 - 8e-57 192.6 1.5 1.3e-56 191.9 1.5 1.3 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 PAP2 PF01569.21 EFC46201.1 - 5.6e-12 45.6 6.4 5.6e-12 45.6 6.4 2.2 2 0 0 2 2 2 1 PAP2 superfamily FRB_dom PF08771.11 EFC46202.1 - 0.046 14.1 0.0 0.8 10.2 0.0 2.4 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain Snf7 PF03357.21 EFC46203.1 - 2.6e-29 102.0 25.2 3.2e-29 101.7 25.2 1.1 1 0 0 1 1 1 1 Snf7 Pepsin-I3 PF06394.13 EFC46203.1 - 0.15 12.3 12.9 0.24 11.6 1.1 3.2 2 1 1 3 3 3 0 Pepsin inhibitor-3-like repeated domain PspA_IM30 PF04012.12 EFC46203.1 - 0.15 11.6 21.8 1.3 8.6 21.8 2.3 1 1 0 1 1 1 0 PspA/IM30 family BORCS7 PF16088.5 EFC46203.1 - 0.22 11.8 9.5 0.8 10.0 9.4 2.1 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 7 Exonuc_VII_L PF02601.15 EFC46203.1 - 0.41 10.2 13.6 0.55 9.7 13.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FliJ PF02050.16 EFC46203.1 - 2.1 8.6 24.2 0.49 10.6 16.0 2.5 2 1 1 3 3 3 0 Flagellar FliJ protein HisKA PF00512.25 EFC46203.1 - 2.6 8.1 5.4 1.4 9.0 0.9 2.7 2 2 0 2 2 2 0 His Kinase A (phospho-acceptor) domain SNase PF00565.17 EFC46203.1 - 4.1 7.9 8.9 1.6 9.3 5.0 2.0 1 1 1 2 2 2 0 Staphylococcal nuclease homologue NPV_P10 PF05531.12 EFC46203.1 - 6.6 7.3 16.9 36 4.9 8.3 3.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Prominin PF05478.11 EFC46203.1 - 7.9 4.3 15.3 10 3.9 15.3 1.1 1 0 0 1 1 1 0 Prominin Kinetochor_Ybp2 PF08568.10 EFC46204.1 - 1.8e-17 63.1 2.0 1.8e-17 63.1 2.0 3.0 1 1 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin YjbH PF06082.11 EFC46206.1 - 0.1 11.4 1.3 0.13 11.0 1.3 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Exo_endo_phos PF03372.23 EFC46207.1 - 2.3e-06 27.3 0.0 4.5e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-PARP PF00645.18 EFC46208.1 - 0.00028 21.7 0.6 0.00066 20.5 0.6 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region F-box PF00646.33 EFC46208.1 - 0.061 13.2 0.3 0.26 11.2 0.1 2.2 2 0 0 2 2 2 0 F-box domain Pkinase PF00069.25 EFC46209.1 - 4.6e-64 216.3 0.0 5.4e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46209.1 - 7.7e-46 156.5 0.0 9.7e-46 156.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC46209.1 - 5.4e-05 22.6 0.1 0.00018 20.9 0.1 1.9 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 EFC46209.1 - 7e-05 21.9 0.3 9.4e-05 21.5 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC46209.1 - 0.00012 21.1 0.0 0.00017 20.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC46209.1 - 0.034 14.1 0.0 0.12 12.3 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family TBPIP_N PF15517.6 EFC46209.1 - 0.057 13.5 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 TBP-interacting protein N-terminus Kdo PF06293.14 EFC46209.1 - 0.096 12.0 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Abi_2 PF07751.11 EFC46209.1 - 0.11 12.8 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Abi-like protein Myb_DNA-bind_6 PF13921.6 EFC46210.1 - 0.0001 22.5 0.7 0.0034 17.6 0.1 3.3 3 0 0 3 3 3 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 EFC46210.1 - 0.0025 18.0 0.0 0.028 14.6 0.0 2.4 2 0 0 2 2 2 1 Myb-like DNA-binding domain RIC3 PF15361.6 EFC46210.1 - 0.38 11.1 5.6 0.58 10.5 3.5 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 WD40 PF00400.32 EFC46211.1 - 4.7e-15 55.7 5.0 0.14 13.1 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC46211.1 - 9.5e-06 25.8 1.5 0.72 10.2 0.0 5.4 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup88 PF10168.9 EFC46211.1 - 0.00063 17.7 0.2 0.0011 16.9 0.2 1.3 1 0 0 1 1 1 1 Nuclear pore component FlaE PF07559.14 EFC46211.1 - 0.066 13.8 1.4 6.2 7.4 0.1 3.1 2 1 0 2 2 2 0 Flagellar basal body protein FlaE RNA_pol_Rpb4 PF03874.16 EFC46211.1 - 0.099 13.0 5.2 0.67 10.3 2.1 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb4 AAA_6 PF12774.7 EFC46212.1 - 2.5e-155 516.4 0.0 3e-154 512.9 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC46212.1 - 1.5e-109 366.8 19.6 1.5e-109 366.8 19.6 4.7 5 0 0 5 5 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EFC46212.1 - 6.1e-105 350.8 0.0 6.1e-105 350.8 0.0 2.3 2 0 0 2 2 1 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EFC46212.1 - 1.1e-103 346.1 0.0 4.1e-103 344.2 0.0 2.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFC46212.1 - 5.7e-80 267.6 7.3 5.7e-80 267.6 7.3 4.0 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFC46212.1 - 1e-63 214.2 0.0 4.7e-59 198.9 0.0 4.4 4 0 0 4 4 4 1 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC46212.1 - 5.4e-56 188.9 0.0 1.4e-55 187.5 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC46212.1 - 4.4e-44 149.4 2.4 4.8e-43 146.0 0.1 3.5 4 0 0 4 4 2 1 Dynein heavy chain region D6 P-loop domain Dynein_AAA_lid PF17852.1 EFC46212.1 - 1.3e-31 109.3 0.6 8.3e-31 106.8 0.6 2.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MT PF12777.7 EFC46212.1 - 1.8e-26 93.0 14.4 4.7e-26 91.6 14.5 1.7 1 1 1 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 EFC46212.1 - 8.5e-24 84.1 0.0 1.1e-06 28.7 0.0 5.7 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFC46212.1 - 8.2e-16 58.1 0.1 8.5e-15 54.8 0.0 2.9 2 0 0 2 2 1 1 AAA+ lid domain AAA PF00004.29 EFC46212.1 - 3.6e-07 30.7 0.1 0.13 12.7 0.0 5.0 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC46212.1 - 1.1e-05 25.7 3.2 0.76 10.0 0.0 5.9 5 0 0 5 5 4 2 AAA domain AAA_18 PF13238.6 EFC46212.1 - 1.2e-05 25.9 0.8 1.5 9.4 0.0 5.3 5 0 0 5 5 4 1 AAA domain AAA_16 PF13191.6 EFC46212.1 - 0.00022 21.7 0.2 4 7.8 0.0 5.6 5 1 0 5 5 5 1 AAA ATPase domain RNA_helicase PF00910.22 EFC46212.1 - 0.0004 20.7 0.1 2.8 8.4 0.0 4.1 3 0 0 3 3 3 1 RNA helicase Sigma54_activat PF00158.26 EFC46212.1 - 0.0011 18.8 0.1 4.8 6.9 0.0 4.2 4 0 0 4 4 4 1 Sigma-54 interaction domain T2SSE PF00437.20 EFC46212.1 - 0.0022 17.1 0.1 3.6 6.6 0.0 4.1 4 0 0 4 4 4 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EFC46212.1 - 0.0024 17.8 0.1 0.49 10.3 0.0 4.0 3 0 0 3 3 3 1 RsgA GTPase FANCI_HD1 PF14679.6 EFC46212.1 - 0.04 13.9 1.9 0.13 12.2 0.1 3.0 2 0 0 2 2 2 0 FANCI helical domain 1 Mg_chelatase PF01078.21 EFC46212.1 - 0.082 12.3 0.1 1.2 8.5 0.0 2.9 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI GAPES4 PF17157.4 EFC46212.1 - 0.096 13.1 1.5 0.5 10.8 0.5 2.7 2 0 0 2 2 2 0 Gammaproteobacterial periplasmic sensor domain ABC_tran PF00005.27 EFC46212.1 - 1.1 9.7 5.4 46 4.5 0.0 5.5 5 0 0 5 5 5 0 ABC transporter SMC_N PF02463.19 EFC46213.1 - 3.5e-24 85.5 1.5 3.5e-24 85.5 1.5 1.8 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFC46213.1 - 8.2e-11 42.2 0.0 2e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EFC46213.1 - 6.4e-09 36.0 41.7 8.2e-08 32.3 30.2 3.8 2 2 1 3 3 3 2 AAA ATPase domain AAA_23 PF13476.6 EFC46213.1 - 2.4e-08 34.7 50.6 1.2e-07 32.5 32.0 4.3 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFC46213.1 - 4.2e-06 26.4 0.0 3.7e-05 23.4 0.0 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 EFC46213.1 - 6.4e-05 22.9 0.1 6.4e-05 22.9 0.1 2.1 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 EFC46213.1 - 0.0016 18.6 0.0 0.073 13.3 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 EFC46213.1 - 0.0051 17.3 6.5 0.12 12.9 0.1 3.5 3 1 0 3 3 3 1 ABC transporter AAA_24 PF13479.6 EFC46213.1 - 0.015 15.0 0.9 0.8 9.4 0.1 2.7 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 EFC46213.1 - 0.028 14.8 0.0 7.5 7.0 0.0 2.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DNA_repr_REX1B PF14966.6 EFC46213.1 - 0.064 13.9 1.2 0.25 12.0 0.7 2.3 1 1 0 1 1 1 0 DNA repair REX1-B RNA_helicase PF00910.22 EFC46213.1 - 0.073 13.5 0.1 29 5.1 0.0 3.5 3 0 0 3 3 3 0 RNA helicase DUF4795 PF16043.5 EFC46214.1 - 6.8e-08 32.4 0.2 6.8e-08 32.4 0.2 5.4 3 1 1 4 4 4 1 Domain of unknown function (DUF4795) PSRP-3_Ycf65 PF04839.13 EFC46214.1 - 0.035 14.3 0.1 0.26 11.5 0.1 2.4 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) PLATZ PF04640.14 EFC46214.1 - 0.25 12.0 8.6 1.3 9.6 0.7 3.8 3 0 0 3 3 3 0 PLATZ transcription factor PHD PF00628.29 EFC46214.1 - 2.3 8.2 22.1 0.76 9.7 13.0 3.0 3 0 0 3 3 3 0 PHD-finger Methyltransf_31 PF13847.6 EFC46214.1 - 3.7 7.3 7.7 0.89 9.3 0.4 3.3 3 0 0 3 3 3 0 Methyltransferase domain C1_1 PF00130.22 EFC46214.1 - 4.2 7.3 11.6 0.28 11.1 4.6 2.6 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Thioredoxin PF00085.20 EFC46216.1 - 2.2e-21 75.7 0.1 2.5e-21 75.6 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFC46216.1 - 1.5e-06 28.6 0.1 1.1e-05 25.9 0.1 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFC46216.1 - 0.013 15.8 0.2 2.5 8.5 0.1 2.5 1 1 1 2 2 2 0 Thioredoxin-like Tim17 PF02466.19 EFC46217.1 - 4.1e-28 98.0 4.5 4.7e-28 97.8 4.5 1.0 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Romo1 PF10247.9 EFC46217.1 - 0.23 11.8 8.3 7.8 6.9 3.5 3.4 1 1 1 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Bacteriocin_IIc PF10439.9 EFC46217.1 - 0.29 11.3 8.0 1.2 9.3 0.3 2.5 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide Pro_isomerase PF00160.21 EFC46220.1 - 3.7e-27 95.5 0.0 5.7e-27 94.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD F-box-like PF12937.7 EFC46220.1 - 0.042 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 F-box-like RIBIOP_C PF04950.12 EFC46221.1 - 3.4e-104 348.4 11.3 2.3e-75 253.8 0.3 3.0 3 0 0 3 3 3 2 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFC46221.1 - 1.6e-19 69.7 0.9 1.2e-18 67.0 0.0 3.0 4 0 0 4 4 4 1 AARP2CN (NUC121) domain DUF812 PF05667.11 EFC46222.1 - 3.1e-95 320.3 62.1 3.1e-95 320.3 62.1 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF812) Sterile PF03015.19 EFC46222.1 - 0.0082 16.3 0.8 0.037 14.3 0.1 2.6 2 1 0 2 2 2 1 Male sterility protein TFIID-31kDa PF02291.15 EFC46223.1 - 9.7e-41 138.7 0.5 1.2e-40 138.3 0.5 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 EFC46223.1 - 2e-09 37.3 0.0 3.3e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TAF PF02969.17 EFC46223.1 - 6.1e-07 29.5 0.0 8.4e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 EFC46223.1 - 2.3e-06 27.9 0.1 4e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 EFC46223.1 - 0.00075 19.9 0.6 0.0017 18.7 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFC46223.1 - 0.012 15.8 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold ANAPC4_WD40 PF12894.7 EFC46224.1 - 6.9e-16 58.3 0.0 0.14 12.5 0.0 5.7 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC46224.1 - 6.6e-10 39.4 0.0 0.044 14.7 0.0 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 EFC46224.1 - 0.0016 18.4 0.2 0.13 12.3 0.1 3.2 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Reg_prop PF07494.11 EFC46224.1 - 0.004 17.2 0.0 6.4 7.4 0.0 4.1 3 0 0 3 3 3 1 Two component regulator propeller WD40_like PF17005.5 EFC46224.1 - 0.0054 16.1 1.8 0.98 8.7 0.3 3.2 2 1 0 3 3 3 1 WD40-like domain Frtz PF11768.8 EFC46224.1 - 0.0083 14.5 0.0 3.8 5.7 0.0 2.8 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 EFC46224.1 - 0.02 15.4 0.0 1.2 9.7 0.0 3.0 3 1 0 3 3 3 0 PQQ-like domain Coatomer_WDAD PF04053.14 EFC46224.1 - 0.025 13.7 0.5 0.89 8.5 0.3 2.7 1 1 0 2 2 2 0 Coatomer WD associated region SdiA-regulated PF06977.11 EFC46224.1 - 0.028 13.6 0.0 0.14 11.3 0.0 2.0 3 0 0 3 3 3 0 SdiA-regulated Hira PF07569.11 EFC46224.1 - 0.049 13.4 0.1 2.2 7.9 0.0 2.5 2 1 1 3 3 3 0 TUP1-like enhancer of split RIB43A PF05914.12 EFC46225.1 - 7.5e-106 354.0 62.0 9.1e-106 353.8 62.0 1.0 1 0 0 1 1 1 1 RIB43A TPALS PF18178.1 EFC46225.1 - 0.073 12.5 4.1 1.3 8.4 1.1 2.5 1 1 1 2 2 2 0 TIR- and PNP-associating SLOG family DUF4476 PF14771.6 EFC46226.1 - 0.059 13.7 1.8 0.34 11.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4476) Prefoldin_2 PF01920.20 EFC46227.1 - 2.8e-13 49.7 9.3 3e-13 49.6 9.3 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF5623 PF18536.1 EFC46227.1 - 0.065 13.5 0.0 0.093 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5623) EXOSC1 PF10447.9 EFC46228.1 - 1.2e-12 48.4 4.6 8.2e-09 36.1 0.0 3.2 2 1 1 3 3 3 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 EFC46228.1 - 1.5e-12 47.0 0.4 3.8e-12 45.8 0.4 1.7 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region Ldh_1_C PF02866.18 EFC46229.1 - 6.1e-40 136.9 0.1 1.3e-39 135.8 0.1 1.6 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 EFC46229.1 - 3.6e-34 117.9 0.1 6e-34 117.1 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain RCDG1 PF15725.5 EFC46229.1 - 0.14 12.6 0.7 1.3 9.5 0.0 2.3 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein WT1 PF02165.15 EFC46230.1 - 0.17 11.1 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Wilm's tumour protein YMF19 PF02326.15 EFC46231.1 - 0.091 13.6 5.2 2.3 9.0 0.8 3.2 2 1 0 2 2 2 0 Plant ATP synthase F0 PqqD PF05402.12 EFC46231.1 - 0.35 11.2 1.6 2 8.7 0.5 2.7 4 0 0 4 4 4 0 Coenzyme PQQ synthesis protein D (PqqD) DUF4446 PF14584.6 EFC46231.1 - 0.79 9.7 8.1 2.1 8.3 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Lebercilin PF15619.6 EFC46231.1 - 0.85 9.2 12.5 0.18 11.4 3.5 2.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease HAUS6_N PF14661.6 EFC46231.1 - 2.3 7.7 17.1 0.059 12.9 1.5 2.6 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus DUF3450 PF11932.8 EFC46231.1 - 2.6 7.3 16.9 1.2 8.4 4.7 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF3450) Nop PF01798.18 EFC46232.1 - 0.042 13.3 3.0 0.78 9.2 0.0 2.9 2 0 0 2 2 2 0 snoRNA binding domain, fibrillarin SPARC_Ca_bdg PF10591.9 EFC46232.1 - 0.047 14.0 2.7 7.8 6.9 0.1 3.5 2 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF5071 PF16804.5 EFC46232.1 - 0.067 13.5 1.7 5.4 7.3 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5071) ParcG PF10274.9 EFC46232.1 - 0.15 12.1 2.5 1.9 8.6 0.2 3.6 3 0 0 3 3 3 0 Parkin co-regulated protein EF-hand_7 PF13499.6 EFC46233.1 - 2.4e-21 75.9 0.2 2.8e-10 40.5 0.0 2.4 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC46233.1 - 2.2e-20 70.6 4.6 0.0001 21.6 0.0 5.2 5 1 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 EFC46233.1 - 2.6e-20 70.5 0.9 2e-05 24.1 0.0 4.7 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 EFC46233.1 - 9.1e-17 59.7 3.2 3.7e-06 26.2 0.0 4.6 4 1 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 EFC46233.1 - 2.7e-15 55.9 2.1 0.0021 17.9 0.1 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 EFC46233.1 - 1.3e-07 31.8 0.0 0.0034 17.7 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFC46233.1 - 0.0016 18.4 0.2 4.6 7.3 0.1 3.3 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC46233.1 - 0.004 17.4 0.0 0.12 12.7 0.0 2.7 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region CXCR4_N PF12109.8 EFC46233.1 - 0.075 13.2 1.0 6.7 7.0 0.0 2.6 3 0 0 3 3 3 0 CXCR4 Chemokine receptor N terminal Dockerin_1 PF00404.18 EFC46233.1 - 0.11 12.7 0.1 5.5 7.3 0.0 2.5 2 1 1 3 3 3 0 Dockerin type I domain DUF4201 PF13870.6 EFC46234.1 - 6.9e-32 110.6 31.1 6.9e-32 110.6 31.1 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4201) DASH_Spc34 PF08657.10 EFC46234.1 - 0.0046 16.8 6.2 0.0046 16.8 6.2 3.4 1 1 1 2 2 2 1 DASH complex subunit Spc34 IF-2B PF01008.17 EFC46234.1 - 0.0062 15.8 10.5 0.052 12.8 1.1 2.3 2 0 0 2 2 2 2 Initiation factor 2 subunit family MHB PF16525.5 EFC46234.1 - 0.052 13.8 0.4 3.9 7.8 0.1 2.7 2 0 0 2 2 2 0 Haemophore, haem-binding Rab5-bind PF09311.11 EFC46234.1 - 0.2 11.0 32.7 5.7 6.2 32.4 3.2 1 1 0 1 1 1 0 Rabaptin-like protein TPR_MLP1_2 PF07926.12 EFC46234.1 - 1.1 9.3 34.6 3.3 7.8 17.2 3.4 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein RNA_pol_Rpb2_4 PF04566.13 EFC46234.1 - 1.9 8.8 7.1 7.2 7.0 0.4 3.5 2 1 1 3 3 3 0 RNA polymerase Rpb2, domain 4 Med30 PF11315.8 EFC46234.1 - 2.2 8.5 23.4 1 9.6 2.5 3.6 1 1 2 3 3 3 0 Mediator complex subunit 30 ZapB PF06005.12 EFC46234.1 - 2.8 8.5 39.3 0.38 11.2 6.2 4.8 2 1 1 4 4 4 0 Cell division protein ZapB Ntox1 PF15500.6 EFC46234.1 - 3.1 8.2 6.2 0.64 10.4 0.3 2.7 2 2 0 2 2 2 0 Putative RNase-like toxin, toxin_1 TMF_TATA_bd PF12325.8 EFC46234.1 - 7.8 6.8 40.4 0.54 10.5 10.9 3.5 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Yuri_gagarin PF15934.5 EFC46234.1 - 8.8 6.1 30.6 5.1 6.9 19.1 2.2 1 1 1 2 2 2 0 Yuri gagarin Vps16_N PF04841.13 EFC46235.1 - 6.3e-88 295.3 0.0 9.7e-88 294.7 0.0 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 EFC46235.1 - 2.3e-80 270.0 10.0 2.3e-80 270.0 10.0 1.6 2 0 0 2 2 2 1 Vps16, C-terminal region BRAP2 PF07576.12 EFC46235.1 - 0.18 12.1 0.7 25 5.2 0.0 3.1 2 1 0 2 2 2 0 BRCA1-associated protein 2 MRP-L20 PF12824.7 EFC46236.1 - 6.8e-05 23.1 1.6 0.0002 21.6 0.0 2.5 2 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 HECT PF00632.25 EFC46237.1 - 8.2e-96 321.1 0.2 9.3e-96 320.9 0.2 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF4498 PF14926.6 EFC46237.1 - 0.018 14.3 0.1 0.058 12.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4498) VHP PF02209.19 EFC46238.1 - 0.017 15.2 0.1 0.034 14.2 0.1 1.5 1 0 0 1 1 1 0 Villin headpiece domain rve_2 PF13333.6 EFC46238.1 - 0.042 14.0 0.9 0.13 12.4 0.9 1.9 1 1 0 1 1 1 0 Integrase core domain PRP1_N PF06424.12 EFC46238.1 - 0.48 10.8 4.9 0.16 12.3 1.2 2.0 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal Tubulin PF00091.25 EFC46239.1 - 3.7e-47 161.1 0.2 7.7e-46 156.8 0.2 2.2 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EFC46239.1 - 0.00093 18.5 0.0 0.0021 17.3 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 EFC46239.1 - 0.0029 17.3 0.0 0.0098 15.6 0.0 1.9 2 0 0 2 2 2 1 Tubulin domain IBV_3B PF03622.13 EFC46239.1 - 0.024 14.8 0.0 0.065 13.4 0.0 1.7 1 0 0 1 1 1 0 IBV 3B protein Tubulin_C PF03953.17 EFC46239.1 - 0.048 13.8 0.1 0.12 12.6 0.1 1.8 1 0 0 1 1 1 0 Tubulin C-terminal domain PRiA4_ORF3 PF07929.11 EFC46241.1 - 3.4e-06 26.9 0.0 0.00015 21.5 0.0 2.3 1 1 1 2 2 2 1 Plasmid pRiA4b ORF-3-like protein PNISR PF15996.5 EFC46241.1 - 0.00011 22.5 3.1 0.0026 18.1 1.5 2.3 2 0 0 2 2 2 1 Arginine/serine-rich protein PNISR Apt1 PF10351.9 EFC46241.1 - 0.0058 15.5 4.2 0.0083 15.0 4.2 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain BUD22 PF09073.10 EFC46241.1 - 0.024 14.0 10.8 0.042 13.2 10.8 1.4 1 0 0 1 1 1 0 BUD22 DUF4614 PF15391.6 EFC46241.1 - 0.081 12.9 10.9 0.17 11.8 10.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) PI3K_1B_p101 PF10486.9 EFC46241.1 - 0.17 9.7 4.8 0.21 9.3 4.8 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pox_RNA_Pol_19 PF05320.12 EFC46241.1 - 0.51 10.3 2.7 1.1 9.2 2.7 1.6 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit FAM104 PF15434.6 EFC46241.1 - 1.2 9.7 12.1 0.6 10.7 9.6 1.8 2 0 0 2 2 2 0 Family 104 Macoilin PF09726.9 EFC46241.1 - 3.1 6.2 10.0 3.7 6.0 9.8 1.3 1 1 0 1 1 1 0 Macoilin family MMU163 PF17119.5 EFC46241.1 - 5.6 6.0 6.3 0.47 9.6 1.1 1.8 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis AAT PF03417.16 EFC46242.1 - 1.5e-07 31.3 0.0 2.5e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase RGS PF00615.19 EFC46243.1 - 1.1e-05 25.7 8.6 2.3e-05 24.6 8.6 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain START PF01852.19 EFC46243.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.4 1 0 0 1 1 1 0 START domain Ras PF00071.22 EFC46244.1 - 3.2e-47 160.1 0.0 3.9e-47 159.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46244.1 - 1.3e-19 70.6 0.0 1.9e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46244.1 - 1e-12 47.9 0.0 1.3e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Kinesin PF00225.23 EFC46245.1 - 1.8e-64 217.8 0.1 2.7e-64 217.2 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC46245.1 - 3.2e-11 43.4 0.0 1.4e-10 41.3 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding AAA_22 PF13401.6 EFC46245.1 - 0.029 14.6 0.7 0.33 11.2 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 EFC46245.1 - 0.058 13.8 0.1 1.2 9.5 0.0 2.2 1 1 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 EFC46245.1 - 0.072 12.6 0.2 0.19 11.2 0.2 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF87 PF01935.17 EFC46245.1 - 0.56 10.3 3.0 0.57 10.2 0.2 2.3 3 0 0 3 3 3 0 Helicase HerA, central domain Dsh_C PF12316.8 EFC46246.1 - 0.17 12.3 7.1 0.28 11.6 7.1 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Sec62 PF03839.16 EFC46246.1 - 8 5.9 8.5 14 5.1 8.5 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 GTP_EFTU PF00009.27 EFC46247.1 - 3.8e-47 160.4 0.0 5.4e-47 159.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 EFC46247.1 - 4.6e-24 85.3 15.7 2.2e-23 83.1 10.4 2.8 2 1 0 2 2 2 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 EFC46247.1 - 1.7e-23 82.7 0.0 3.3e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFC46247.1 - 5.1e-18 64.9 0.0 1.2e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFC46247.1 - 4.9e-14 52.5 0.0 1.2e-13 51.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFC46247.1 - 1.1e-07 31.8 0.1 2.4e-07 30.8 0.1 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 EFC46247.1 - 1.6e-05 25.0 0.1 3.6e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EFC46247.1 - 0.00098 18.8 0.1 0.0039 16.8 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC46247.1 - 0.002 18.3 0.0 0.049 13.9 0.0 2.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFC46247.1 - 0.0047 17.0 0.3 1.8 8.6 0.1 2.5 1 1 1 2 2 2 2 Dynamin family DKCLD PF08068.12 EFC46247.1 - 0.071 13.2 0.0 0.21 11.7 0.0 1.8 1 0 0 1 1 1 0 DKCLD (NUC011) domain Complex1_LYR_2 PF13233.6 EFC46248.1 - 4.4e-11 43.4 5.4 2.1e-10 41.2 5.3 1.9 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EFC46248.1 - 9e-06 25.6 0.4 1.9e-05 24.6 0.4 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) CdvA PF18822.1 EFC46248.1 - 0.013 15.3 1.0 0.024 14.5 1.0 1.3 1 0 0 1 1 1 0 CdvA-like coiled-coil domain CRR7 PF12095.8 EFC46248.1 - 0.036 14.5 0.6 0.063 13.7 0.6 1.4 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 TPT PF03151.16 EFC46249.1 - 2.3e-07 30.4 12.2 4.3e-07 29.6 12.2 1.5 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC46249.1 - 5.7e-07 29.8 13.0 5.7e-07 29.8 13.0 1.9 2 1 1 3 3 3 1 EamA-like transporter family Multi_Drug_Res PF00893.19 EFC46249.1 - 0.0074 16.9 4.1 0.016 15.8 3.2 2.0 1 1 0 1 1 1 1 Small Multidrug Resistance protein Cytomega_TRL10 PF06084.11 EFC46249.1 - 0.21 11.6 0.1 0.36 10.8 0.1 1.3 1 0 0 1 1 1 0 Cytomegalovirus TRL10 protein MtN3_slv PF03083.16 EFC46249.1 - 0.39 10.8 15.0 0.67 10.0 1.4 3.0 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange adh_short PF00106.25 EFC46250.1 - 5e-31 107.7 2.1 6.8e-28 97.5 0.6 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC46250.1 - 1.3e-22 80.5 0.2 4.1e-21 75.6 0.1 2.0 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC46250.1 - 1.6e-07 31.4 0.1 2.7e-07 30.7 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC46250.1 - 2.2e-06 27.3 0.1 3.4e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family E1_dh PF00676.20 EFC46250.1 - 0.029 13.3 0.0 0.051 12.5 0.0 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component 2-Hacid_dh_C PF02826.19 EFC46250.1 - 0.037 13.4 0.1 0.08 12.3 0.1 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 EFC46250.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SCAI PF12070.8 EFC46253.1 - 1.3e-118 397.3 23.0 5.1e-84 283.1 8.0 3.0 1 1 1 2 2 2 2 Protein SCAI G-alpha PF00503.20 EFC46254.1 - 1.6e-40 139.4 4.6 3.3e-40 138.3 4.6 1.5 1 0 0 1 1 1 1 G-protein alpha subunit Pkinase PF00069.25 EFC46255.1 - 1.5e-22 80.2 8.4 1.2e-21 77.3 8.4 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46255.1 - 4.7e-17 62.1 0.8 2.3e-12 46.8 0.9 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase DUF4116 PF13475.6 EFC46255.1 - 1.9e-15 56.3 6.0 8.2e-06 25.4 0.1 5.2 4 1 0 4 4 4 3 Domain of unknown function (DUF4116) Kdo PF06293.14 EFC46255.1 - 1.8e-05 24.2 0.3 3.9e-05 23.1 0.3 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFC46255.1 - 6.6e-05 22.6 1.2 0.00014 21.5 1.2 1.5 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 EFC46255.1 - 0.0016 17.3 0.2 0.0029 16.4 0.2 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC46255.1 - 0.0018 17.6 0.1 0.082 12.2 0.1 2.3 2 0 0 2 2 2 1 Kinase-like Arm-DNA-bind_2 PF12167.8 EFC46255.1 - 0.015 15.2 0.1 0.041 13.8 0.1 1.7 1 0 0 1 1 1 0 Arm DNA-binding domain Choline_kinase PF01633.20 EFC46255.1 - 0.025 14.2 4.2 0.02 14.5 2.1 2.0 2 0 0 2 2 2 0 Choline/ethanolamine kinase Importin_rep_5 PF18816.1 EFC46255.1 - 1.2 9.5 3.1 1.9 8.9 0.0 2.7 3 0 0 3 3 3 0 Importin repeat Phage_TAC_12 PF12363.8 EFC46255.1 - 1.5 9.2 5.9 0.3 11.5 0.2 2.8 3 0 0 3 3 3 0 Phage tail assembly chaperone protein, TAC DNA_pol_A PF00476.20 EFC46256.1 - 1.3e-134 449.0 0.3 1.3e-134 449.0 0.3 2.1 2 0 0 2 2 2 1 DNA polymerase family A 5_3_exonuc_N PF02739.16 EFC46256.1 - 3.7e-43 147.2 0.0 9.6e-43 145.8 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain 5_3_exonuc PF01367.20 EFC46256.1 - 4.8e-26 91.2 0.3 4.8e-26 91.2 0.3 3.2 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold DNA_pol_A_exo1 PF01612.20 EFC46256.1 - 5.6e-12 45.7 0.1 5.6e-12 45.7 0.1 2.0 2 0 0 2 2 2 1 3'-5' exonuclease HHH_5 PF14520.6 EFC46256.1 - 0.011 16.3 0.9 0.034 14.8 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain NYN_YacP PF05991.11 EFC46256.1 - 0.27 11.1 0.1 0.27 11.1 0.1 2.7 2 0 0 2 2 2 0 YacP-like NYN domain DUF1619 PF07773.11 EFC46257.1 - 6.1e-56 190.7 28.1 1.8e-53 182.5 18.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1619) FtsJ PF01728.19 EFC46258.1 - 1.9e-37 129.1 0.0 3.7e-37 128.2 0.0 1.5 2 0 0 2 2 2 1 FtsJ-like methyltransferase G-patch PF01585.23 EFC46258.1 - 5.9e-07 29.3 3.2 1.1e-06 28.4 3.2 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFC46258.1 - 0.064 13.3 0.5 0.17 12.0 0.5 1.8 1 0 0 1 1 1 0 G-patch domain MOZ_SAS PF01853.18 EFC46259.1 - 2.3e-85 284.8 0.3 4.1e-85 283.9 0.3 1.4 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 EFC46259.1 - 1.2e-26 92.1 3.6 1.2e-26 92.1 3.6 2.3 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 EFC46259.1 - 2.1e-12 46.7 0.4 5.1e-12 45.5 0.4 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF2314 PF10077.9 EFC46259.1 - 0.038 14.1 0.1 0.077 13.1 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2314) IF2_N PF04760.15 EFC46259.1 - 0.055 13.3 0.1 0.14 12.0 0.0 1.7 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region HTH_24 PF13412.6 EFC46259.1 - 0.058 13.0 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Endonuclease_NS PF01223.23 EFC46260.1 - 2.6e-44 151.7 0.0 2.8e-44 151.6 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.6 EFC46260.1 - 0.076 13.1 0.1 0.44 10.7 0.1 2.0 1 1 0 1 1 1 0 DNA/RNA non-specific endonuclease DUF4116 PF13475.6 EFC46261.1 - 1.2e-66 220.2 16.0 3.5e-12 45.9 0.0 8.6 3 2 6 10 10 10 10 Domain of unknown function (DUF4116) Sacchrp_dh_C PF16653.5 EFC46262.1 - 1.3e-72 245.1 0.0 2.5e-71 240.9 0.0 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.15 EFC46262.1 - 5.7e-25 88.2 0.1 4.4e-24 85.3 0.0 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.18 EFC46262.1 - 2.3e-12 47.3 0.0 1.2e-11 45.0 0.0 2.3 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 EFC46262.1 - 8.9e-07 28.4 0.0 0.00031 20.1 0.0 3.5 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GFO_IDH_MocA PF01408.22 EFC46262.1 - 0.031 15.1 0.0 0.069 14.0 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Ras PF00071.22 EFC46263.1 - 3.8e-51 172.9 0.2 4.3e-51 172.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46263.1 - 4.7e-31 107.5 0.3 1.1e-30 106.4 0.3 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46263.1 - 2.6e-17 62.8 0.3 3.6e-17 62.4 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC46263.1 - 9.2e-10 38.6 0.3 1.5e-09 37.9 0.3 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC46263.1 - 4.7e-06 26.1 0.1 7.7e-06 25.5 0.1 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 EFC46263.1 - 7.6e-06 25.6 0.3 0.00086 18.9 0.3 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC46263.1 - 3.7e-05 23.2 0.2 5.2e-05 22.7 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Dynamin_N PF00350.23 EFC46263.1 - 0.0012 19.0 1.0 0.073 13.1 0.5 2.3 1 1 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 EFC46263.1 - 0.0023 17.5 0.8 0.0034 16.9 0.2 1.8 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC46263.1 - 0.0034 17.3 1.9 0.089 12.7 0.3 2.6 2 1 1 3 3 3 1 RsgA GTPase Septin PF00735.18 EFC46263.1 - 0.0091 15.3 0.0 0.017 14.4 0.0 1.5 1 0 0 1 1 1 1 Septin DUF676 PF05057.14 EFC46263.1 - 0.046 13.2 0.4 0.11 12.0 0.2 1.6 2 0 0 2 2 2 0 Putative serine esterase (DUF676) AAA_16 PF13191.6 EFC46263.1 - 0.11 12.9 0.0 0.12 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DLH PF01738.18 EFC46264.1 - 4.2e-41 140.9 0.1 4.7e-41 140.7 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EFC46264.1 - 7.6e-05 22.6 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFC46264.1 - 0.00063 19.1 0.1 0.047 13.0 0.2 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 EFC46264.1 - 0.011 15.6 0.2 3.4 7.5 0.1 2.2 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC46264.1 - 0.012 15.1 0.2 0.79 9.1 0.3 2.1 1 1 1 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC46264.1 - 0.13 11.9 0.1 0.23 11.0 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 EFC46264.1 - 0.15 12.0 0.3 0.15 12.0 0.3 2.3 2 1 1 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal RNase_PH PF01138.21 EFC46265.1 - 3e-26 92.5 0.2 7.1e-26 91.3 0.1 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 Mic1 PF07035.12 EFC46269.1 - 3.1e-28 98.4 2.9 7.4e-28 97.2 2.9 1.6 1 0 0 1 1 1 1 Colon cancer-associated protein Mic1-like RGS PF00615.19 EFC46270.1 - 1.9e-06 28.2 1.0 1.9e-06 28.2 1.0 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain BLOC1_2 PF10046.9 EFC46270.1 - 1.2 9.5 5.6 1.2 9.5 1.6 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 KLRAQ PF10205.9 EFC46270.1 - 1.6 9.0 5.3 10 6.4 0.6 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Fib_alpha PF08702.10 EFC46270.1 - 2 8.6 5.7 4.6 7.4 0.3 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4064 PF13273.6 EFC46270.1 - 3 8.2 10.6 1.1 9.6 7.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Peptidase_M48_N PF16491.5 EFC46270.1 - 9.2 6.1 14.5 23 4.8 14.4 1.7 1 1 0 1 1 1 0 CAAX prenyl protease N-terminal, five membrane helices EFG_IV PF03764.18 EFC46271.1 - 3.5e-22 78.4 0.0 8.1e-22 77.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU PF00009.27 EFC46271.1 - 4.8e-13 49.1 0.0 1.4e-12 47.6 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EFC46271.1 - 4.9e-07 29.8 0.0 9.8e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 EFC46271.1 - 2.4e-06 27.5 0.0 6.6e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 EFC46271.1 - 0.00016 21.7 0.0 0.00033 20.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 EFC46271.1 - 0.0002 21.7 0.0 0.00043 20.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Roc PF08477.13 EFC46271.1 - 0.0006 20.0 0.0 0.0012 19.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EFC46271.1 - 0.005 16.2 0.0 0.0097 15.2 0.0 1.5 1 0 0 1 1 1 1 Septin SRPRB PF09439.10 EFC46271.1 - 0.005 16.3 0.2 0.0093 15.4 0.2 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC46271.1 - 0.03 13.9 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 Ras family LysR_substrate PF03466.20 EFC46271.1 - 0.11 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 LysR substrate binding domain Fzo_mitofusin PF04799.13 EFC46271.1 - 0.12 11.9 0.0 0.34 10.4 0.0 1.7 1 0 0 1 1 1 0 fzo-like conserved region Sel1 PF08238.12 EFC46273.1 - 5.1e-37 125.5 12.3 1e-07 32.4 0.1 6.6 7 0 0 7 7 7 6 Sel1 repeat TPR_1 PF00515.28 EFC46273.1 - 0.91 9.5 6.5 9.4 6.2 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC46273.1 - 4.1 7.2 7.8 19 5.1 0.0 4.1 5 0 0 5 5 5 0 TPR repeat TPR_2 PF07719.17 EFC46273.1 - 8.2 6.8 8.9 14 6.1 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Exo_endo_phos PF03372.23 EFC46274.1 - 4.5e-08 32.9 0.0 9.4e-08 31.9 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RNase_3_N PF18497.1 EFC46274.1 - 0.03 14.5 1.1 0.068 13.4 0.3 1.9 2 0 0 2 2 2 0 Ribonuclease III N-terminal domain IF-2B PF01008.17 EFC46275.1 - 8.7e-75 251.5 1.3 1e-74 251.3 1.3 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family WD40 PF00400.32 EFC46276.1 - 9.2e-33 111.8 17.0 9.7e-10 38.9 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC46276.1 - 6.6e-12 45.6 0.4 0.0027 18.0 0.0 5.6 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain DUF501 PF04417.12 EFC46276.1 - 0.057 13.2 0.1 0.42 10.4 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF501) Sin_N PF04801.13 EFC46276.1 - 0.53 9.4 9.9 0.78 8.9 9.9 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region Hydantoinase_A PF01968.18 EFC46277.1 - 0.067 12.4 0.0 0.081 12.2 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Dsl1_N PF11988.8 EFC46277.1 - 0.14 11.1 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal SIR2 PF02146.17 EFC46279.1 - 1.6e-47 161.7 0.0 2.8e-47 160.9 0.0 1.4 1 0 0 1 1 1 1 Sir2 family zinc_ribbon_15 PF17032.5 EFC46279.1 - 0.032 15.0 0.6 0.14 12.9 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon family zinc_ribbon_4 PF13717.6 EFC46279.1 - 0.12 12.3 1.8 0.54 10.2 1.8 2.2 1 1 0 1 1 1 0 zinc-ribbon domain ANTH PF07651.16 EFC46280.1 - 6.1e-33 114.0 0.3 8.4e-33 113.5 0.3 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 EFC46280.1 - 1.5e-06 28.3 0.1 4.1e-06 26.8 0.0 1.8 2 0 0 2 2 2 1 ENTH domain KptA_kDCL PF18176.1 EFC46280.1 - 0.15 12.0 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain DENN PF02141.21 EFC46281.1 - 2e-25 89.8 1.2 5.1e-21 75.5 0.5 3.2 2 0 0 2 2 2 2 DENN (AEX-3) domain PH PF00169.29 EFC46281.1 - 1.4e-11 44.9 0.4 6.9e-06 26.5 0.7 3.2 1 1 1 2 2 2 2 PH domain PH_11 PF15413.6 EFC46281.1 - 0.00056 20.3 0.2 0.00056 20.3 0.2 3.3 3 0 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.6 EFC46281.1 - 0.0016 18.7 0.7 0.0096 16.2 0.4 2.5 1 1 1 2 2 2 1 Pleckstrin homology domain dDENN PF03455.19 EFC46281.1 - 0.0019 18.2 0.6 0.011 15.7 0.6 2.4 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 EFC46281.1 - 0.013 16.3 6.9 0.12 13.1 0.0 3.9 4 0 0 4 4 4 0 uDENN domain PH_3 PF14593.6 EFC46281.1 - 0.022 14.8 0.1 0.08 13.1 0.1 1.9 1 0 0 1 1 1 0 PH domain BRICHOS PF04089.14 EFC46282.1 - 0.18 12.1 2.5 0.28 11.5 0.2 2.5 2 1 0 2 2 2 0 BRICHOS domain GIDA_assoc PF13932.6 EFC46282.1 - 1.4 9.0 8.4 0.13 12.4 1.4 2.2 2 0 0 2 2 2 0 GidA associated domain RGS PF00615.19 EFC46283.1 - 5.3e-12 46.1 4.5 5.3e-12 46.1 4.5 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain PIN_12 PF16289.5 EFC46284.1 - 2.3 8.7 13.3 0.053 14.0 2.6 2.4 2 1 0 2 2 2 0 PIN domain RWP-RK PF02042.15 EFC46285.1 - 1.7e-09 37.5 0.0 3e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 RWP-RK domain HTH_3 PF01381.22 EFC46285.1 - 0.0035 17.4 0.1 0.019 15.0 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.6 EFC46285.1 - 0.012 15.6 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain MAGUK_N_PEST PF10608.9 EFC46285.1 - 0.021 15.3 6.5 0.028 14.9 3.1 2.5 2 1 0 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK HTH_Tnp_ISL3 PF13542.6 EFC46285.1 - 0.032 13.7 0.1 0.066 12.6 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Alpha-E PF04168.12 EFC46285.1 - 0.037 13.8 0.1 0.051 13.4 0.1 1.1 1 0 0 1 1 1 0 A predicted alpha-helical domain with a conserved ER motif. HTH_24 PF13412.6 EFC46285.1 - 0.067 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 EFC46285.1 - 0.076 12.8 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_psq PF05225.16 EFC46285.1 - 0.086 12.6 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Sigma70_r4_2 PF08281.12 EFC46285.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 DUF134 PF02001.16 EFC46285.1 - 0.18 12.4 0.0 0.32 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF134 HTH_31 PF13560.6 EFC46285.1 - 0.22 11.9 0.0 0.37 11.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain E1-E2_ATPase PF00122.20 EFC46286.1 - 3.3e-33 114.7 0.7 1.2e-32 112.9 0.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC46286.1 - 8.6e-14 52.3 0.0 3e-07 30.9 0.0 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase P5-ATPase PF12409.8 EFC46286.1 - 2.1e-08 34.3 1.3 2.1e-08 34.3 1.3 3.0 3 0 0 3 3 3 1 P5-type ATPase cation transporter Cation_ATPase PF13246.6 EFC46286.1 - 1.1e-06 28.7 0.0 2.2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC46286.1 - 7.2e-05 22.7 0.0 0.68 9.6 0.0 3.2 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFC46286.1 - 0.0017 18.0 4.1 0.0035 17.0 0.1 3.2 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Aldo_ket_red PF00248.21 EFC46287.1 - 4e-77 259.3 0.0 5e-77 259.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HpuA PF16960.5 EFC46287.1 - 0.045 12.9 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter Acetyltransf_10 PF13673.7 EFC46290.1 - 1.2e-09 38.2 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC46290.1 - 9.8e-07 29.1 0.0 1.4e-06 28.6 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC46290.1 - 1.6e-06 28.4 0.0 2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 EFC46290.1 - 0.0055 16.7 0.0 0.011 15.6 0.0 1.6 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 EFC46290.1 - 0.0071 16.4 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase LpxB PF02684.15 EFC46290.1 - 0.13 11.1 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase PNP_UDP_1 PF01048.20 EFC46291.1 - 5.3e-32 111.0 0.0 2.3e-30 105.6 0.0 2.4 3 0 0 3 3 3 2 Phosphorylase superfamily Folliculin PF11704.8 EFC46292.1 - 0.00087 19.2 4.5 0.0015 18.5 2.1 2.6 2 1 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport MADF_DNA_bdg PF10545.9 EFC46292.1 - 0.11 12.8 1.4 0.42 11.0 1.4 2.0 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like G-alpha PF00503.20 EFC46293.1 - 8.2e-123 410.0 9.9 9.9e-123 409.8 9.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC46293.1 - 2.4e-13 49.9 0.9 3.9e-08 32.9 0.5 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC46293.1 - 2.2e-05 23.9 1.8 0.014 14.8 0.4 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC46293.1 - 0.00057 19.5 0.2 0.02 14.5 0.1 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC46293.1 - 0.005 16.9 0.2 1.3 9.1 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EFC46293.1 - 0.03 14.5 1.4 1.5 9.0 0.0 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 EFC46293.1 - 0.06 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 EFC46293.1 - 0.071 12.5 0.0 7.9 5.9 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 EFC46293.1 - 0.076 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Malic_M PF03949.15 EFC46293.1 - 0.16 11.3 0.4 2 7.6 0.1 2.2 2 0 0 2 2 2 0 Malic enzyme, NAD binding domain G-alpha PF00503.20 EFC46294.1 - 4.1e-18 65.7 18.8 9.3e-18 64.5 18.8 1.5 1 1 0 1 1 1 1 G-protein alpha subunit AAA_18 PF13238.6 EFC46294.1 - 0.02 15.4 0.5 2.6 8.6 0.2 2.4 2 0 0 2 2 2 0 AAA domain LisH_2 PF16045.5 EFC46294.1 - 0.14 11.2 0.1 7.5 5.7 0.0 2.4 2 0 0 2 2 2 0 LisH ADH_N PF08240.12 EFC46295.1 - 2.3e-08 33.9 0.1 4.6e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 EFC46295.1 - 3.8e-05 23.7 0.0 8.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC46295.1 - 0.0086 17.1 0.0 0.043 14.9 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Guanylate_cyc PF00211.20 EFC46296.1 - 2.1e-07 30.8 0.2 7.2e-07 29.0 0.1 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain SNAPc19 PF15497.6 EFC46296.1 - 0.016 15.6 5.6 1.5 9.3 0.2 3.9 3 0 0 3 3 3 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 ANAPC3 PF12895.7 EFC46296.1 - 0.13 12.5 0.1 19 5.5 0.1 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 GIT_CC PF16559.5 EFC46296.1 - 0.14 12.1 8.0 0.028 14.3 3.0 2.6 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSNAXIP1_N PF15739.5 EFC46296.1 - 0.14 12.6 2.7 23 5.4 1.0 3.1 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus TPR_2 PF07719.17 EFC46296.1 - 0.15 12.3 0.1 3.9 7.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat FlaC_arch PF05377.11 EFC46296.1 - 0.65 10.4 5.0 1 9.8 1.9 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 EFC46296.1 - 1.5 9.1 4.1 2.3 8.5 1.0 3.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Mt_ATP-synt_D PF05873.12 EFC46296.1 - 7 6.5 8.9 9.1 6.1 0.3 3.9 4 0 0 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) Shugoshin_N PF07558.11 EFC46296.1 - 7.6 6.5 8.1 0.73 9.8 2.8 2.1 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region TLE_N PF03920.15 EFC46296.1 - 7.7 6.6 6.8 7.3 6.7 0.9 3.3 4 0 0 4 4 4 0 Groucho/TLE N-terminal Q-rich domain RGS PF00615.19 EFC46298.1 - 9.3e-17 61.4 4.8 4.5e-16 59.2 4.8 2.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain RNA_pol_A_CTD PF03118.15 EFC46298.1 - 0.029 14.1 0.2 0.17 11.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial RNA polymerase, alpha chain C terminal domain TLV_coat PF00429.19 EFC46298.1 - 0.38 9.4 4.5 0.71 8.5 4.5 1.4 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) RecG_N PF17190.4 EFC46299.1 - 0.075 13.8 3.3 0.75 10.6 0.5 2.9 1 1 1 2 2 2 0 RecG N-terminal helical domain p450 PF00067.22 EFC46300.1 - 1.3e-54 185.7 0.0 1.6e-54 185.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF2258 PF10015.9 EFC46300.1 - 0.057 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) PQ-loop PF04193.14 EFC46300.1 - 0.089 12.6 0.4 0.17 11.7 0.4 1.4 1 0 0 1 1 1 0 PQ loop repeat Guanylate_cyc PF00211.20 EFC46301.1 - 0.00051 19.7 0.1 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ferlin_C PF16165.5 EFC46301.1 - 0.078 12.9 0.2 0.078 12.9 0.2 2.5 2 0 0 2 2 2 0 Ferlin C-terminus DUF4974 PF16344.5 EFC46301.1 - 0.1 12.6 0.6 9.7 6.3 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4974) TPR_2 PF07719.17 EFC46301.1 - 0.13 12.4 0.2 0.32 11.2 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat GHMP_kinases_N PF00288.26 EFC46302.1 - 2.2e-13 50.2 1.7 6.3e-12 45.6 1.7 2.6 1 1 0 1 1 1 1 GHMP kinases N terminal domain ERG2_Sigma1R PF04622.12 EFC46302.1 - 3.9 6.8 12.9 0.068 12.5 1.3 3.0 3 0 0 3 3 3 0 ERG2 and Sigma1 receptor like protein Cofilin_ADF PF00241.20 EFC46303.1 - 2.4e-06 27.3 0.1 2.9e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Pallilysin PF18663.1 EFC46303.1 - 0.061 13.3 0.2 1.5 8.8 0.1 2.2 2 0 0 2 2 2 0 Pallilysin beta barrel domain OKR_DC_1_N PF03709.15 EFC46303.1 - 0.14 12.5 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Mito_carr PF00153.27 EFC46304.1 - 1.8e-40 136.8 5.0 6.9e-14 51.5 0.0 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Herpes_ICP4_N PF03584.15 EFC46304.1 - 0.064 13.1 0.0 2.5 7.9 0.0 2.3 2 0 0 2 2 2 0 Herpesvirus ICP4-like protein N-terminal region DBD_Tnp_Mut PF03108.15 EFC46304.1 - 0.1 12.6 0.0 10 6.2 0.0 2.5 2 0 0 2 2 2 0 MuDR family transposase Ribosomal_L30 PF00327.20 EFC46305.1 - 6e-18 64.5 1.5 1.1e-17 63.7 1.5 1.4 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 EFC46305.1 - 7.3e-15 55.0 13.9 7.3e-15 55.0 13.9 1.9 2 0 0 2 2 2 1 Ribosomal L30 N-terminal domain CREPT PF16566.5 EFC46305.1 - 0.032 14.4 4.4 0.057 13.6 4.4 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour RasGEF PF00617.19 EFC46306.1 - 1.3e-28 100.4 1.8 1.3e-28 100.4 1.8 3.5 3 1 0 3 3 3 1 RasGEF domain DOCK-C2 PF14429.6 EFC46306.1 - 1.6e-26 93.3 3.4 1.6e-26 93.3 3.4 3.1 4 0 0 4 4 4 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC46306.1 - 0.0016 18.7 3.3 0.0016 18.7 3.3 6.0 4 1 0 4 4 4 1 RasGEF N-terminal motif TPR_2 PF07719.17 EFC46307.1 - 1.4e-25 87.3 0.1 0.00054 19.9 0.0 8.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46307.1 - 4.3e-21 73.3 0.0 0.0051 16.9 0.0 7.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46307.1 - 9.4e-18 63.2 2.4 0.069 13.0 0.0 9.3 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46307.1 - 1.3e-16 60.8 0.0 0.0002 21.8 0.0 5.2 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFC46307.1 - 9e-14 51.8 0.0 0.0028 18.3 0.0 5.6 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC46307.1 - 9.9e-14 50.9 0.0 0.1 13.5 0.0 7.4 1 1 6 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC46307.1 - 4.4e-12 46.0 0.0 0.22 11.7 0.0 4.6 3 2 1 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46307.1 - 6.9e-12 44.9 0.0 0.099 13.1 0.0 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC46307.1 - 6.6e-11 42.3 0.5 0.023 14.9 0.0 4.1 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFC46307.1 - 1.3e-08 35.0 0.3 0.072 13.4 0.0 5.4 2 1 4 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC46307.1 - 2.4e-08 34.1 0.0 6.3 7.7 0.0 7.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC46307.1 - 2.4e-06 27.1 0.2 1.8 8.3 0.1 4.6 4 0 0 4 4 4 3 TPR repeat TPR_7 PF13176.6 EFC46307.1 - 3e-05 23.7 0.9 1.1 9.4 0.0 5.7 7 0 0 7 7 7 1 Tetratricopeptide repeat NARP1 PF12569.8 EFC46307.1 - 0.00098 18.1 0.2 2 7.2 0.2 3.6 2 1 2 4 4 4 1 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 EFC46307.1 - 0.01 15.5 0.0 4.3 7.0 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 EFC46307.1 - 0.018 14.9 0.0 4.3 7.3 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 EFC46307.1 - 0.054 14.1 0.0 52 4.9 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DP PF08781.10 EFC46308.1 - 0.028 14.3 1.9 0.12 12.3 0.7 2.1 2 0 0 2 2 2 0 Transcription factor DP Tctex-1 PF03645.13 EFC46309.1 - 6e-26 90.7 0.3 6.8e-26 90.5 0.3 1.0 1 0 0 1 1 1 1 Tctex-1 family ThrE PF06738.12 EFC46311.1 - 5.9e-41 140.4 3.0 5.9e-41 140.4 3.0 2.6 3 0 0 3 3 3 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EFC46311.1 - 2.2e-06 27.8 9.9 2.2e-06 27.8 9.9 3.3 2 1 1 3 3 3 2 Threonine/Serine exporter, ThrE SART-1 PF03343.13 EFC46312.1 - 2.4e-20 72.7 53.0 6.3e-07 28.3 23.6 3.3 1 1 2 3 3 3 3 SART-1 family RGS PF00615.19 EFC46313.1 - 3.4e-08 33.8 15.5 9.7e-08 32.3 12.6 3.0 2 1 0 2 2 2 1 Regulator of G protein signaling domain ApbE PF02424.15 EFC46313.1 - 0.038 13.5 0.3 0.066 12.7 0.3 1.4 1 0 0 1 1 1 0 ApbE family PBP_dimer PF03717.15 EFC46313.1 - 0.14 12.5 3.2 0.33 11.3 3.2 1.6 1 0 0 1 1 1 0 Penicillin-binding Protein dimerisation domain RCC1 PF00415.18 EFC46314.1 - 0.02 15.5 0.0 7 7.4 0.0 2.6 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat RAI1 PF08652.11 EFC46314.1 - 0.044 14.0 0.4 0.088 13.0 0.4 1.5 1 0 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease RCC1_2 PF13540.6 EFC46314.1 - 0.064 13.1 0.1 2.8 7.8 0.0 3.3 4 0 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat RNase_T PF00929.24 EFC46315.1 - 1.4e-31 110.3 1.6 1.9e-31 109.8 1.6 1.2 1 0 0 1 1 1 1 Exonuclease Y1_Tnp PF01797.16 EFC46315.1 - 0.022 14.8 2.3 1.6 8.8 0.1 2.2 1 1 1 2 2 2 0 Transposase IS200 like DUF999 PF06198.11 EFC46315.1 - 0.058 13.4 4.4 0.05 13.6 2.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF999) ABC_membrane PF00664.23 EFC46316.1 - 3.6e-51 174.4 11.7 4.9e-51 174.0 11.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC46316.1 - 2.5e-32 112.2 0.0 6.2e-32 111.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC46316.1 - 8.8e-07 28.6 0.2 0.00074 19.0 0.0 2.4 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC46316.1 - 0.0005 19.8 0.1 0.0015 18.3 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC46316.1 - 0.00061 20.2 0.6 0.0028 18.1 0.1 2.4 3 1 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 EFC46316.1 - 0.0017 18.1 0.2 0.0081 15.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFC46316.1 - 0.0058 16.9 0.0 0.039 14.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC46316.1 - 0.012 15.5 0.0 0.052 13.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 EFC46316.1 - 0.026 14.5 0.1 0.54 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 EFC46316.1 - 0.027 14.2 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 EFC46316.1 - 0.046 14.2 0.1 8 6.9 0.0 2.6 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 EFC46316.1 - 0.1 11.3 0.1 0.23 10.2 0.0 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class LETM1 PF07766.13 EFC46317.1 - 8.6e-101 336.8 2.8 8.6e-101 336.8 2.8 1.9 2 0 0 2 2 2 1 LETM1-like protein EF-hand_1 PF00036.32 EFC46317.1 - 4.1e-10 38.5 2.7 7.7e-05 22.0 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 EFC46317.1 - 2.1e-09 37.7 0.8 2.1e-09 37.7 0.8 3.5 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC46317.1 - 3.2e-09 36.0 2.2 0.00013 21.6 0.1 4.1 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EFC46317.1 - 6.9e-09 35.4 0.3 3e-08 33.4 0.3 2.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFC46317.1 - 9.3e-08 31.2 5.5 0.00012 21.4 0.1 3.4 3 0 0 3 3 3 2 EF hand EAP30 PF04157.16 EFC46317.1 - 0.00039 19.8 1.3 0.004 16.5 0.4 2.7 2 1 0 2 2 2 1 EAP30/Vps36 family SPARC_Ca_bdg PF10591.9 EFC46317.1 - 0.0035 17.6 4.7 0.0077 16.5 0.2 2.9 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region TipAS PF07739.13 EFC46317.1 - 0.012 16.2 2.3 0.48 11.0 0.0 3.6 4 0 0 4 4 4 0 TipAS antibiotic-recognition domain Phage_TAC_12 PF12363.8 EFC46317.1 - 5.7 7.4 13.3 0.88 10.0 0.8 3.8 2 2 0 3 3 3 0 Phage tail assembly chaperone protein, TAC CRR7 PF12095.8 EFC46317.1 - 7.5 7.1 9.8 12 6.4 1.3 4.1 4 0 0 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 Pkinase PF00069.25 EFC46318.1 - 1.7e-60 204.7 0.0 1.9e-60 204.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46318.1 - 7.3e-40 136.9 0.0 1.8e-39 135.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC46318.1 - 3.2e-10 39.8 0.0 1.1e-09 38.1 0.0 1.8 1 1 1 2 2 2 1 Kinase-like RL PF17797.1 EFC46318.1 - 0.02 14.8 0.3 0.034 14.1 0.3 1.4 1 0 0 1 1 1 0 RL domain DUF825 PF05695.12 EFC46318.1 - 0.023 11.9 0.1 0.029 11.5 0.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF825) GatB_N PF02934.15 EFC46319.1 - 3.2e-102 341.6 0.0 4.1e-102 341.2 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 EFC46319.1 - 7.7e-37 126.4 0.8 1.1e-36 125.9 0.8 1.3 1 0 0 1 1 1 1 GatB domain Importin_rep_5 PF18816.1 EFC46319.1 - 0.088 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Importin repeat Phage_CP76 PF06892.11 EFC46319.1 - 0.12 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) FPL PF09758.9 EFC46320.1 - 3.8e-59 199.0 9.1 3.8e-59 199.0 9.1 2.5 2 1 0 2 2 2 1 Uncharacterised conserved protein HTH_26 PF13443.6 EFC46320.1 - 0.0074 16.7 0.0 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain MVP_shoulder PF11978.8 EFC46320.1 - 0.013 15.5 0.5 5.9 6.9 0.2 2.6 2 0 0 2 2 2 0 Shoulder domain DUF3361 PF11841.8 EFC46320.1 - 0.024 14.6 7.8 1.3 9.0 3.3 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF3361) RIX1 PF08167.12 EFC46320.1 - 0.046 13.5 0.4 0.42 10.3 0.1 2.4 2 0 0 2 2 2 0 rRNA processing/ribosome biogenesis Ribosomal_S26e PF01283.19 EFC46321.1 - 1.7e-46 157.1 5.9 1.9e-46 157.0 5.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf-ribbon_3 PF13248.6 EFC46321.1 - 0.13 11.7 0.2 0.13 11.7 0.2 1.9 2 0 0 2 2 2 0 zinc-ribbon domain zf-dskA_traR PF01258.17 EFC46321.1 - 0.19 11.7 1.1 3 7.9 0.0 2.4 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger DUF35_N PF12172.8 EFC46321.1 - 0.48 10.3 2.3 0.98 9.4 0.1 2.4 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_4 PF13717.6 EFC46321.1 - 2.3 8.2 5.5 0.4 10.6 0.5 2.2 2 1 0 2 2 2 0 zinc-ribbon domain Mut7-C PF01927.16 EFC46322.1 - 1.5e-25 90.0 6.5 1.5e-24 86.8 6.4 2.1 1 1 0 1 1 1 1 Mut7-C RNAse domain DUF5615 PF18480.1 EFC46322.1 - 0.022 14.5 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) zf_CopZ PF18423.1 EFC46322.1 - 0.3 11.1 3.3 0.34 10.9 1.1 2.2 2 0 0 2 2 2 0 Zinc binding domain Phage_holin_3_6 PF07332.11 EFC46323.1 - 0.078 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DSPc PF00782.20 EFC46324.1 - 1.7e-16 60.2 0.7 6.1e-16 58.4 0.0 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain AAA_18 PF13238.6 EFC46325.1 - 2.7e-28 99.1 0.1 4.1e-28 98.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFC46325.1 - 4.5e-07 30.4 0.0 8.4e-07 29.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 EFC46325.1 - 0.0001 22.7 0.0 0.00017 22.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC46325.1 - 0.00031 21.2 0.0 0.00036 21.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EFC46325.1 - 0.00041 19.7 0.4 0.00077 18.8 0.4 1.5 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 EFC46325.1 - 0.00057 20.2 0.1 0.0016 18.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFC46325.1 - 0.0011 19.0 0.5 0.0022 18.0 0.1 1.6 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 EFC46325.1 - 0.0012 18.6 0.2 0.056 13.1 0.1 2.2 2 0 0 2 2 2 1 Thymidylate kinase NTPase_1 PF03266.15 EFC46325.1 - 0.0044 17.0 2.5 0.0071 16.3 0.3 2.2 2 1 0 2 2 2 1 NTPase AAA_33 PF13671.6 EFC46325.1 - 0.0047 17.1 0.0 0.9 9.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 EFC46325.1 - 0.0066 16.3 2.3 0.012 15.5 0.1 2.1 1 1 0 2 2 2 1 Deoxynucleoside kinase ATPase_2 PF01637.18 EFC46325.1 - 0.01 15.8 1.4 0.022 14.7 1.4 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea FtsK_SpoIIIE PF01580.18 EFC46325.1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_7 PF12775.7 EFC46325.1 - 0.013 15.0 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 EFC46325.1 - 0.018 15.4 0.2 0.023 15.1 0.2 1.5 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 EFC46325.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 EFC46325.1 - 0.026 13.6 0.5 0.048 12.7 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein RNA_helicase PF00910.22 EFC46325.1 - 0.038 14.4 0.1 0.1 13.0 0.0 1.8 2 0 0 2 2 2 0 RNA helicase ATPase PF06745.13 EFC46325.1 - 0.038 13.3 0.9 0.055 12.8 0.2 1.6 2 1 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 EFC46325.1 - 0.048 13.0 0.0 0.076 12.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 EFC46325.1 - 0.081 12.6 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain ResIII PF04851.15 EFC46325.1 - 0.093 12.7 0.1 0.13 12.3 0.1 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit MeaB PF03308.16 EFC46325.1 - 0.21 10.5 0.1 0.6 9.0 0.1 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CENP-C_C PF11699.8 EFC46326.1 - 5.2e-09 36.2 0.0 1e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 EFC46326.1 - 2.9e-07 30.1 0.0 5.2e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EFC46326.1 - 2.2e-05 24.1 1.0 5.7e-05 22.8 0.0 2.0 2 0 0 2 2 2 1 Cupin PH_12 PF16457.5 EFC46327.1 - 0.00038 21.0 0.4 0.00038 21.0 0.4 4.4 4 1 0 4 4 4 1 Pleckstrin homology domain HK_sensor PF16750.5 EFC46327.1 - 0.0051 17.1 7.0 0.073 13.4 0.1 4.5 4 0 0 4 4 4 1 Sensor domain of 2-component histidine kinase Mcp5_PH PF12814.7 EFC46327.1 - 0.018 15.2 0.0 0.098 12.8 0.0 2.3 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology PRA1 PF03208.19 EFC46328.1 - 3.1e-13 49.6 12.7 5.7e-13 48.7 12.7 1.3 1 0 0 1 1 1 1 PRA1 family protein DUF648 PF04890.13 EFC46328.1 - 0.024 14.4 2.1 0.062 13.1 2.1 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF648) SCAMP PF04144.13 EFC46329.1 - 1.8e-26 93.5 18.3 2.2e-26 93.2 18.3 1.1 1 0 0 1 1 1 1 SCAMP family DUF4282 PF14110.6 EFC46329.1 - 6.1 7.7 18.9 1.3 9.8 2.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) RRM_1 PF00076.22 EFC46330.1 - 6.5e-24 83.5 0.3 9.5e-11 41.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC46330.1 - 5.2e-07 29.3 0.1 0.011 15.3 0.1 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC46330.1 - 9.9e-06 25.3 0.1 0.033 14.1 0.1 2.5 2 1 0 2 2 2 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 EFC46330.1 - 0.038 14.2 6.8 1.1 9.4 2.5 3.2 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Rad52_Rad22 PF04098.15 EFC46331.1 - 3.6e-07 30.2 0.0 4.8e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ras PF00071.22 EFC46332.1 - 1.1e-34 119.4 0.2 1.3e-34 119.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46332.1 - 4.2e-20 72.2 0.1 9e-20 71.1 0.0 1.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46332.1 - 4.6e-06 26.2 0.0 6.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC46332.1 - 0.0032 16.9 0.1 0.0039 16.6 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC46332.1 - 0.0071 16.4 0.0 0.02 15.0 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 EFC46332.1 - 0.025 14.3 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EFC46332.1 - 0.077 13.5 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter TniB PF05621.11 EFC46332.1 - 0.19 11.1 0.0 0.32 10.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Pkinase PF00069.25 EFC46333.1 - 2.1e-23 83.0 1.5 1.8e-12 47.2 0.1 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46333.1 - 1.1e-10 41.3 0.7 1.2e-08 34.5 0.1 3.1 3 0 0 3 3 3 1 Protein tyrosine kinase SSFA2_C PF14723.6 EFC46333.1 - 0.061 13.2 2.7 0.79 9.6 0.7 2.8 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus DUF3391 PF11871.8 EFC46333.1 - 0.14 12.7 0.4 1.6 9.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) LRR_4 PF12799.7 EFC46334.1 - 0.00013 22.2 3.0 0.00013 22.2 3.0 5.6 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46334.1 - 0.0003 20.5 31.7 0.0034 17.1 1.9 5.3 4 1 0 5 5 5 3 Leucine rich repeat Pyridoxal_deC PF00282.19 EFC46335.1 - 1.6e-24 86.4 0.0 2.5e-24 85.7 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 EFC46335.1 - 0.0031 16.5 0.0 0.0048 15.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFC46335.1 - 0.023 13.9 0.0 0.1 11.7 0.0 1.8 1 1 0 1 1 1 0 Aminotransferase class I and II KxDL PF10241.9 EFC46336.1 - 1.9e-19 69.7 3.6 3.1e-19 69.0 3.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein CCDC154 PF15450.6 EFC46336.1 - 0.0084 14.7 2.2 0.011 14.3 2.2 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 154 HAUS6_N PF14661.6 EFC46336.1 - 0.022 14.3 0.3 0.024 14.2 0.3 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus ThylakoidFormat PF11264.8 EFC46336.1 - 0.06 13.0 2.0 0.084 12.6 2.0 1.2 1 0 0 1 1 1 0 Thylakoid formation protein Snf7 PF03357.21 EFC46336.1 - 0.071 12.7 7.6 0.059 13.0 6.2 1.6 1 1 0 1 1 1 0 Snf7 DUF2730 PF10805.8 EFC46336.1 - 0.095 12.8 0.8 0.16 12.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Spore-coat_CotD PF11122.8 EFC46336.1 - 0.14 12.9 1.9 0.31 11.9 0.1 1.9 2 0 0 2 2 2 0 Inner spore coat protein D CH PF00307.31 EFC46337.1 - 2.3e-74 246.6 7.9 3.6e-18 65.7 0.0 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFC46337.1 - 1.8e-08 34.1 0.1 0.12 12.2 0.0 4.2 4 0 0 4 4 4 3 CAMSAP CH domain CH_2 PF06294.11 EFC46337.1 - 1.2e-05 25.4 0.2 0.11 12.7 0.0 3.9 5 0 0 5 5 5 2 CH-like domain in sperm protein SHS2_Rpb7-N PF03876.17 EFC46338.1 - 0.14 12.6 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 dCMP_cyt_deam_1 PF00383.23 EFC46339.1 - 2.7e-16 59.3 3.5 3.4e-16 59.0 3.5 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 EFC46339.1 - 3.1e-06 27.4 0.0 4.9e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region CbiG_N PF11760.8 EFC46339.1 - 0.043 13.8 0.0 0.069 13.2 0.0 1.3 1 0 0 1 1 1 0 Cobalamin synthesis G N-terminal APOBEC3 PF18771.1 EFC46339.1 - 0.061 13.4 0.1 0.075 13.1 0.1 1.2 1 0 0 1 1 1 0 APOBEC3 LmjF365940-deam PF14421.6 EFC46339.1 - 0.065 12.8 1.5 0.81 9.3 0.0 2.0 1 1 1 2 2 2 0 A distinct subfamily of CDD/CDA-like deaminases SNAD4 PF18750.1 EFC46339.1 - 0.073 13.2 0.3 0.088 12.9 0.3 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 Zn_clus PF00172.18 EFC46340.1 - 1.7e-09 37.6 9.7 3.8e-09 36.5 9.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRF PF01765.19 EFC46340.1 - 0.004 17.1 1.6 0.0053 16.7 1.6 1.1 1 0 0 1 1 1 1 Ribosome recycling factor NPR3 PF03666.13 EFC46340.1 - 0.0068 15.2 4.9 0.0081 15.0 4.9 1.0 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 FSA_C PF10479.9 EFC46340.1 - 0.09 10.9 2.1 0.087 11.0 2.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ASD2 PF08687.11 EFC46340.1 - 1 8.8 5.0 1.3 8.5 5.0 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SWIRM-assoc_2 PF16496.5 EFC46340.1 - 1.1 8.0 10.2 1.5 7.6 10.2 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal DUF5427 PF10310.9 EFC46340.1 - 7.6 5.4 12.3 8.7 5.2 12.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Ndc1_Nup PF09531.10 EFC46340.1 - 8 5.0 12.5 9.2 4.8 12.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFC46340.1 - 8.4 5.0 6.5 9.4 4.9 6.5 1.1 1 0 0 1 1 1 0 Presenilin GTP_EFTU PF00009.27 EFC46341.1 - 1.2e-52 178.3 0.3 1.9e-52 177.7 0.3 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 EFC46341.1 - 1.1e-20 73.4 0.0 2.5e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFC46341.1 - 3.2e-06 27.5 2.5 8.8e-06 26.0 2.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC46341.1 - 1.4e-05 25.2 0.1 3.5e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EFC46341.1 - 0.0019 17.6 0.2 0.0033 16.8 0.2 1.3 1 0 0 1 1 1 1 Septin tRNA-synt_His PF13393.6 EFC46342.1 - 4.6e-29 101.7 0.0 7.9e-29 100.9 0.0 1.4 1 1 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.25 EFC46342.1 - 8.4e-13 48.7 0.0 2e-12 47.5 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFC46342.1 - 1.2e-12 47.8 0.7 2.9e-12 46.6 0.7 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.20 EFC46342.1 - 0.019 14.4 0.1 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DUF5613 PF18467.1 EFC46342.1 - 0.039 14.4 0.7 0.16 12.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5613) HP0268 PF18618.1 EFC46342.1 - 0.11 12.9 2.6 0.82 10.1 0.1 3.0 3 0 0 3 3 3 0 HP0268 3Beta_HSD PF01073.19 EFC46343.1 - 5.6e-49 166.6 0.1 6.8e-49 166.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC46343.1 - 1.1e-31 110.2 0.0 1.4e-31 109.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC46343.1 - 7.7e-21 74.8 1.7 1.5e-20 73.9 0.9 1.9 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFC46343.1 - 3.1e-14 52.8 0.0 3.8e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 EFC46343.1 - 8.9e-13 48.0 0.7 5.1e-10 39.0 0.1 2.2 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 EFC46343.1 - 1.4e-07 31.6 0.0 2.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFC46343.1 - 1.3e-05 24.5 0.7 0.00011 21.4 0.7 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EFC46343.1 - 0.0018 18.2 1.0 0.34 10.8 1.0 2.8 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 EFC46343.1 - 0.017 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 EFC46343.1 - 0.04 13.4 0.1 0.79 9.1 0.1 2.5 2 1 0 2 2 2 0 short chain dehydrogenase LpxI_N PF17930.1 EFC46343.1 - 0.057 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 LpxI N-terminal domain NAD_binding_2 PF03446.15 EFC46343.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Cmc1 PF08583.10 EFC46344.1 - 1.3e-09 37.9 2.8 1.3e-09 37.9 2.8 2.0 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like DUF1682 PF07946.14 EFC46344.1 - 0.065 12.4 6.6 0.069 12.3 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) UPF0203 PF05254.12 EFC46344.1 - 0.44 10.8 6.9 0.38 11.0 3.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) DUF3128 PF11326.8 EFC46344.1 - 1.4 9.3 8.8 7.2 7.1 8.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Med4 PF10018.9 EFC46345.1 - 1.1e-08 35.1 8.6 1.1e-08 35.1 8.6 2.4 2 2 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 Arf PF00025.21 EFC46346.1 - 2.8e-39 134.4 0.4 6.7e-39 133.1 0.4 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC46346.1 - 7.9e-11 41.7 0.0 2e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit BTB PF00651.31 EFC46346.1 - 0.00013 22.2 0.2 0.00033 20.9 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain MMR_HSR1 PF01926.23 EFC46346.1 - 0.00019 21.5 0.1 0.001 19.1 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 EFC46346.1 - 0.0017 18.0 0.2 0.0057 16.3 0.2 1.9 1 0 0 1 1 1 1 Ras family AAA_24 PF13479.6 EFC46346.1 - 0.0037 17.0 0.5 0.007 16.1 0.5 1.4 1 0 0 1 1 1 1 AAA domain G-alpha PF00503.20 EFC46346.1 - 0.036 13.2 7.6 0.047 12.8 1.6 2.9 1 1 1 2 2 2 0 G-protein alpha subunit PIN_9 PF18477.1 EFC46347.1 - 0.0044 17.3 0.9 0.036 14.4 0.0 2.6 3 0 0 3 3 3 1 PIN like domain Helicase_RecD PF05127.14 EFC46347.1 - 0.005 16.7 0.5 0.012 15.4 0.2 1.8 1 1 1 2 2 2 1 Helicase SPT6_acidic PF14632.6 EFC46347.1 - 0.028 15.0 5.7 0.028 15.0 5.7 2.1 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Minor_capsid_1 PF10665.9 EFC46347.1 - 0.083 13.1 3.7 0.59 10.4 0.1 2.8 2 1 0 2 2 2 0 Minor capsid protein Tli4_N PF18443.1 EFC46347.1 - 0.45 10.9 4.6 1.2 9.5 4.6 1.8 1 1 0 1 1 1 0 Tle cognate immunity protein 4 N-terminal domain F-box-like PF12937.7 EFC46348.1 - 0.047 13.6 0.2 0.24 11.3 0.0 2.1 2 0 0 2 2 2 0 F-box-like F-box PF00646.33 EFC46348.1 - 0.093 12.6 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 F-box domain Glyco_hydro_63 PF03200.16 EFC46349.1 - 5.2e-147 490.5 6.5 2.2e-146 488.5 6.5 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EFC46349.1 - 7.8e-56 189.7 6.0 7.8e-56 189.7 6.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain DUF1948 PF09185.10 EFC46349.1 - 1 9.2 3.8 0.48 10.3 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1948) Snurportin1 PF11538.8 EFC46349.1 - 1.6 9.0 5.7 0.54 10.5 2.1 2.3 2 0 0 2 2 2 0 Snurportin1 IU_nuc_hydro PF01156.19 EFC46350.1 - 7.1e-16 58.6 0.0 8.8e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase CorA PF01544.18 EFC46351.1 - 0.036 13.4 0.3 0.036 13.4 0.3 1.8 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein NDUF_B7 PF05676.13 EFC46352.1 - 5.7e-05 22.8 2.7 5.7e-05 22.8 2.7 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 EFC46352.1 - 0.00027 21.0 4.8 0.0004 20.4 4.8 1.3 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 EFC46352.1 - 0.0003 20.7 3.3 0.00037 20.5 3.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.17 EFC46352.1 - 0.003 17.8 3.3 0.0035 17.5 3.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 EFC46352.1 - 0.0034 17.4 6.4 0.023 14.7 6.2 1.9 1 1 1 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 EFC46352.1 - 0.12 12.7 4.9 0.27 11.6 4.9 1.6 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 PQQ_2 PF13360.6 EFC46353.1 - 4.8e-05 23.1 0.0 0.021 14.4 0.0 2.6 2 1 1 3 3 3 3 PQQ-like domain Zip PF02535.22 EFC46354.1 - 0.015 14.5 0.0 0.033 13.4 0.0 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter SF-assemblin PF06705.11 EFC46354.1 - 0.031 13.6 11.2 0.084 12.2 1.7 3.2 3 0 0 3 3 3 0 SF-assemblin/beta giardin MRFAP1 PF15155.6 EFC46354.1 - 0.033 14.7 0.1 0.74 10.3 0.1 2.4 2 0 0 2 2 2 0 MORF4 family-associated protein1 LOH1CR12 PF10158.9 EFC46354.1 - 0.91 9.5 5.3 0.62 10.1 0.2 3.0 3 1 0 3 3 3 0 Tumour suppressor protein Ashwin PF15323.6 EFC46354.1 - 2.6 8.0 5.4 38 4.2 2.7 2.4 2 0 0 2 2 2 0 Developmental protein DUF3829 PF12889.7 EFC46354.1 - 3.6 7.0 12.1 0.25 10.8 2.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3829) DUF948 PF06103.11 EFC46354.1 - 3.7 7.9 17.2 14 6.1 3.2 5.1 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 EFC46354.1 - 3.7 7.6 29.8 0.13 12.3 0.3 5.1 3 2 3 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_assoc_2 PF16193.5 EFC46355.1 - 0.0037 17.6 0.0 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA C-terminal domain EIIBC-GUT_N PF03612.14 EFC46355.1 - 0.014 15.1 1.1 0.014 15.1 1.1 2.6 2 1 1 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus AAA_14 PF13173.6 EFC46355.1 - 0.067 13.2 2.4 0.45 10.6 0.0 3.6 4 0 0 4 4 4 0 AAA domain MIT_C PF16565.5 EFC46356.1 - 0.034 14.1 1.2 0.039 13.9 0.2 1.6 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT Thioredoxin PF00085.20 EFC46357.1 - 2.1e-10 40.5 0.3 2.9e-10 40.0 0.3 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 EFC46357.1 - 0.0002 21.3 0.0 0.00027 20.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain DUF1704 PF08014.11 EFC46357.1 - 0.068 12.2 0.0 0.084 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1704) Thioredoxin_2 PF13098.6 EFC46357.1 - 0.095 13.2 0.1 0.16 12.4 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Pex2_Pex12 PF04757.14 EFC46358.1 - 1.4e-23 83.7 7.0 1.4e-23 83.7 7.0 2.0 2 0 0 2 2 2 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 EFC46358.1 - 1e-08 34.9 14.2 1.9e-08 34.0 14.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC46358.1 - 1.3e-05 24.9 16.8 3.2e-05 23.7 16.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC46358.1 - 2.9e-05 24.3 16.3 6.7e-05 23.1 16.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 EFC46358.1 - 0.0001 22.2 14.6 0.00024 21.0 14.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 EFC46358.1 - 0.0036 17.1 16.2 0.007 16.2 16.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 EFC46358.1 - 0.0051 16.8 7.9 0.0051 16.8 7.9 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 EFC46358.1 - 0.0081 16.0 16.1 0.017 14.9 16.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Ninjurin PF04923.12 EFC46358.1 - 0.021 14.8 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 Ninjurin Peptidase_S41 PF03572.18 EFC46358.1 - 0.12 11.9 2.0 0.16 11.6 0.9 1.7 2 0 0 2 2 2 0 Peptidase family S41 zf-C3HC4_4 PF15227.6 EFC46358.1 - 2.5 8.3 15.5 34 4.7 16.3 2.3 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 EFC46358.1 - 7.7 6.4 10.9 3.7 7.5 7.4 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit BTB_2 PF02214.22 EFC46359.1 - 1.5e-14 54.1 0.2 3.2e-14 53.0 0.2 1.5 1 0 0 1 1 1 1 BTB/POZ domain SPRY PF00622.28 EFC46359.1 - 1.1e-05 25.6 0.0 1.8e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain DUF3552 PF12072.8 EFC46359.1 - 0.34 10.3 8.1 0.51 9.7 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF737 PF05300.11 EFC46359.1 - 0.76 10.1 5.9 1.1 9.6 5.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF737) OSCP PF00213.18 EFC46359.1 - 3.1 7.9 5.9 0.57 10.3 1.4 1.9 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit FA_hydroxylase PF04116.13 EFC46360.1 - 2.9e-08 34.1 14.6 2.9e-08 34.1 14.6 2.0 1 1 1 2 2 2 1 Fatty acid hydroxylase superfamily RGS PF00615.19 EFC46361.1 - 0.016 15.5 1.2 6.2 7.1 0.0 3.8 3 1 1 4 4 4 0 Regulator of G protein signaling domain PRESAN PF09687.10 EFC46363.1 - 0.028 15.0 8.9 0.075 13.6 8.9 1.7 1 0 0 1 1 1 0 Plasmodium RESA N-terminal FlaC_arch PF05377.11 EFC46363.1 - 0.082 13.3 15.3 0.11 12.9 2.5 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Arm-DNA-bind_2 PF12167.8 EFC46363.1 - 0.25 11.3 1.4 9.5 6.2 0.0 3.1 1 1 1 2 2 2 0 Arm DNA-binding domain XRN_N PF03159.18 EFC46364.1 - 3.2e-72 242.9 1.1 3.2e-72 242.9 1.1 2.2 3 0 0 3 3 3 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFC46364.1 - 1.5e-48 165.9 15.2 5.1e-28 98.2 4.6 3.0 3 0 0 3 3 3 2 Xrn1 helical domain PITH PF06201.13 EFC46364.1 - 5.6e-21 75.3 4.8 5.6e-21 75.3 4.8 2.9 3 0 0 3 3 3 1 PITH domain XRN_N PF03159.18 EFC46365.1 - 6.3e-61 205.9 1.7 6.3e-61 205.9 1.7 3.6 2 1 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 EFC46365.1 - 4.3e-40 138.0 8.8 4.3e-40 138.0 8.8 4.1 3 2 1 4 4 4 1 Xrn1 helical domain Borrelia_P83 PF05262.11 EFC46365.1 - 1.4 7.3 37.0 0.78 8.2 28.2 2.4 2 0 0 2 2 2 0 Borrelia P83/100 protein MOR2-PAG1_N PF14222.6 EFC46366.1 - 1.4e-116 390.6 10.4 3.2e-116 389.5 10.4 1.7 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_mid PF14228.6 EFC46366.1 - 2.4e-66 224.2 15.4 7.4e-28 96.8 1.3 5.2 4 1 1 5 5 5 5 Cell morphogenesis central region MOR2-PAG1_C PF14225.6 EFC46366.1 - 6.7e-57 193.2 0.0 6.7e-57 193.2 0.0 2.8 3 0 0 3 3 3 1 Cell morphogenesis C-terminal RsbRD_N PF14361.6 EFC46366.1 - 3.5 8.4 4.7 2e+02 2.7 0.0 4.8 5 0 0 5 5 5 0 RsbT co-antagonist protein rsbRD N-terminal domain Kelch_6 PF13964.6 EFC46368.1 - 2e-22 78.7 2.6 1.3e-06 28.4 0.0 4.8 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.6 EFC46368.1 - 6.9e-21 74.0 0.6 3e-09 36.9 0.0 5.2 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC46368.1 - 7.5e-21 73.9 6.2 1.7e-07 31.1 0.0 6.4 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC46368.1 - 9.3e-16 57.4 0.4 0.00089 19.2 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 EFC46368.1 - 7.7e-14 51.0 1.4 2e-05 24.1 0.0 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFC46368.1 - 0.00056 19.8 6.1 6.9 6.8 0.1 5.4 6 0 0 6 6 6 2 Kelch motif Epimerase_2 PF02350.19 EFC46369.1 - 5e-91 305.1 1.2 5.8e-89 298.3 0.1 2.4 2 0 0 2 2 2 2 UDP-N-acetylglucosamine 2-epimerase Glyco_tranf_2_3 PF13641.6 EFC46369.1 - 0.00016 21.6 0.1 0.0043 17.0 0.0 2.9 3 1 0 3 3 3 1 Glycosyltransferase like family 2 DUF4862 PF16154.5 EFC46369.1 - 0.0032 16.9 0.0 0.0059 16.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4862) Glycos_transf_2 PF00535.26 EFC46369.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.8 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glycos_transf_N PF04413.16 EFC46369.1 - 0.016 14.8 0.0 0.072 12.7 0.0 2.1 1 1 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Kelch_3 PF13415.6 EFC46370.1 - 7.4e-18 64.4 0.2 3.8e-09 36.6 0.0 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC46370.1 - 2.7e-15 56.0 0.5 1.3e-05 25.3 0.0 4.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 EFC46370.1 - 7.3e-15 54.7 5.8 7.1e-08 32.3 0.1 5.5 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC46370.1 - 2.9e-11 42.8 4.3 0.0001 21.8 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EFC46370.1 - 1.7e-10 40.6 0.8 2.5e-05 24.2 0.0 4.2 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 EFC46370.1 - 0.00088 19.2 9.1 1.6 8.9 0.2 4.9 5 0 0 5 5 5 2 Kelch motif zf-CCCH_7 PF18586.1 EFC46370.1 - 0.081 13.3 0.5 0.21 11.9 0.1 1.9 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 CAF1 PF04857.20 EFC46371.1 - 3.7e-18 65.8 1.1 8e-08 31.8 0.5 2.8 1 1 1 2 2 2 2 CAF1 family ribonuclease RFX_DNA_binding PF02257.15 EFC46371.1 - 0.0057 17.2 0.0 1.3 9.7 0.0 2.5 2 0 0 2 2 2 2 RFX DNA-binding domain NHR2 PF08788.11 EFC46371.1 - 0.054 13.3 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 NHR2 domain like Sel1 PF08238.12 EFC46372.1 - 1.3e-58 194.1 22.3 2.1e-10 40.9 1.8 9.2 9 1 0 9 9 9 8 Sel1 repeat TPR_6 PF13174.6 EFC46372.1 - 1.4e-07 31.7 6.9 3.9 8.3 0.0 7.1 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46372.1 - 1.5e-05 25.2 12.1 1.3 9.4 0.2 6.6 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46372.1 - 9.4e-05 22.2 26.6 0.00068 19.6 0.7 8.6 9 1 1 10 10 10 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46372.1 - 9.4e-05 22.1 0.9 9.4e-05 22.1 0.9 8.4 10 1 0 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC46372.1 - 0.00014 22.4 4.8 0.63 10.7 0.1 5.0 3 1 3 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46372.1 - 0.0014 18.7 0.6 0.0014 18.7 0.6 7.7 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC46372.1 - 0.0088 15.7 17.5 0.057 13.1 0.1 6.2 5 1 0 5 5 5 1 TPR repeat ANAPC8 PF04049.13 EFC46372.1 - 0.022 14.8 0.6 0.048 13.7 0.6 1.6 1 0 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 ANAPC3 PF12895.7 EFC46372.1 - 0.19 12.0 16.1 0.47 10.7 2.3 4.6 4 3 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Ribosomal_L27A PF00828.19 EFC46372.1 - 0.2 12.4 0.6 0.63 10.7 0.8 1.7 2 0 0 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF512 PF04459.12 EFC46372.1 - 0.22 10.8 3.9 3.1 7.0 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF512) TPR_17 PF13431.6 EFC46372.1 - 0.23 11.9 6.3 4.8 7.8 0.2 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC46372.1 - 0.38 10.9 10.8 8.2 6.7 0.1 5.4 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 EFC46372.1 - 0.93 9.4 5.8 11 6.0 0.1 4.5 4 1 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46372.1 - 3.2 8.3 6.5 19 5.9 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 EFC46372.1 - 6.3 6.9 21.5 58 3.9 0.0 6.7 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain HATPase_c PF02518.26 EFC46373.1 - 4.7e-24 85.1 0.3 9.1e-24 84.1 0.3 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC46373.1 - 2.4e-10 40.3 0.2 2.4e-10 40.3 0.2 2.7 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Response_reg PF00072.24 EFC46373.1 - 2.6e-07 30.8 0.1 6e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c_5 PF14501.6 EFC46373.1 - 0.23 11.4 4.0 0.66 9.9 1.9 2.9 2 1 0 2 2 2 0 GHKL domain Epimerase PF01370.21 EFC46374.1 - 5.1e-28 98.2 0.1 7.1e-28 97.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 EFC46374.1 - 4.2e-23 81.8 0.5 1.6e-22 79.9 0.5 1.8 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 EFC46374.1 - 9.6e-23 80.6 0.5 3.2e-21 75.6 0.5 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC46374.1 - 9e-16 58.2 0.1 1.2e-11 44.6 0.3 3.1 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 EFC46374.1 - 9.5e-09 34.8 0.0 4.2e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 RmlD substrate binding domain KR PF08659.10 EFC46374.1 - 2.3e-07 30.9 0.0 1.1e-06 28.6 0.0 2.0 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC46374.1 - 3.7e-07 29.6 0.2 0.0038 16.4 0.0 2.7 2 1 1 3 3 3 2 Polysaccharide biosynthesis protein adh_short PF00106.25 EFC46374.1 - 4e-07 29.7 1.7 0.0002 20.9 0.1 3.0 2 1 1 3 3 3 2 short chain dehydrogenase NAD_binding_10 PF13460.6 EFC46374.1 - 2.8e-05 24.1 0.0 0.0037 17.2 0.0 2.2 1 1 1 2 2 2 1 NAD(P)H-binding adh_short_C2 PF13561.6 EFC46374.1 - 0.00029 20.5 0.1 0.013 15.1 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Semialdhyde_dh PF01118.24 EFC46374.1 - 0.025 15.0 0.0 2.9 8.4 0.0 2.5 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain LRR_9 PF14580.6 EFC46375.1 - 2.8e-12 46.5 0.1 4.3e-12 45.9 0.1 1.3 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC46375.1 - 1.6e-09 37.9 10.8 2.4e-06 27.8 1.4 2.9 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46375.1 - 5.6e-05 22.8 11.3 0.00043 20.0 0.5 3.1 1 1 1 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 EFC46375.1 - 3.7 8.5 8.2 1.5e+02 3.5 0.1 4.2 4 1 0 4 4 4 0 Leucine Rich Repeat Pkinase PF00069.25 EFC46376.1 - 1.8e-08 34.1 1.3 4.4e-08 32.8 1.3 1.7 1 1 0 1 1 1 1 Protein kinase domain YkuD_2 PF13645.6 EFC46376.1 - 0.0024 17.3 0.6 0.0046 16.4 0.6 1.4 1 0 0 1 1 1 1 L,D-transpeptidase catalytic domain TraF_2 PF13729.6 EFC46376.1 - 0.11 11.8 0.2 0.21 10.9 0.2 1.3 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein SET PF00856.28 EFC46377.1 - 9.7e-24 84.6 0.2 7.5e-23 81.8 0.2 1.9 1 1 0 1 1 1 1 SET domain ATP-synt_DE_N PF02823.16 EFC46379.1 - 8.8e-07 28.7 0.0 2.2e-06 27.5 0.0 1.7 2 0 0 2 2 2 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain SLD5_C PF16922.5 EFC46380.1 - 2.8e-15 56.2 0.0 6.1e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 EFC46380.1 - 0.014 15.8 0.5 0.027 14.9 0.5 1.6 1 0 0 1 1 1 0 GINS complex protein APH_6_hur PF04655.14 EFC46380.1 - 0.18 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase DUF2207 PF09972.9 EFC46381.1 - 0.01 14.6 0.0 0.016 14.0 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Podoplanin PF05808.11 EFC46381.1 - 0.12 12.5 0.5 0.12 12.5 0.5 1.5 2 0 0 2 2 2 0 Podoplanin RCC1 PF00415.18 EFC46383.1 - 1.5e-15 57.5 0.7 0.00051 20.6 0.0 4.8 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46383.1 - 1.6e-10 40.5 7.8 5.1e-07 29.3 0.0 4.9 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat DUF4213 PF13938.6 EFC46383.1 - 0.013 15.7 0.0 15 5.9 0.0 3.2 3 0 0 3 3 3 0 Putative heavy-metal chelation DUF3192 PF11399.8 EFC46383.1 - 0.084 12.8 0.1 19 5.3 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3192) TPR_1 PF00515.28 EFC46384.1 - 2.4e-08 33.4 0.1 0.0011 18.7 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46384.1 - 1.2e-06 28.2 0.1 0.065 13.5 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46384.1 - 6.6e-06 25.9 0.0 0.072 13.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2183 PF09949.9 EFC46384.1 - 0.12 12.7 0.2 0.34 11.3 0.2 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) Tom5 PF10642.9 EFC46384.1 - 3.7 7.7 4.5 9.3 6.4 4.5 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase PsbT PF01405.17 EFC46385.1 - 2.4 8.0 6.1 0.87 9.5 3.2 1.7 2 0 0 2 2 2 0 Photosystem II reaction centre T protein PA26 PF04636.13 EFC46386.1 - 0.34 9.8 7.9 0.4 9.6 7.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PDDEXK_6 PF04720.12 EFC46386.1 - 0.5 10.3 7.8 0.63 9.9 7.8 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Coatomer_WDAD PF04053.14 EFC46387.1 - 3.5e-107 359.2 0.0 7e-107 358.2 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 EFC46387.1 - 1.5e-101 340.1 0.0 2.1e-101 339.6 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 EFC46387.1 - 1.1e-39 133.7 16.5 3.8e-09 37.0 0.1 9.1 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC46387.1 - 3.3e-11 43.3 0.8 0.00038 20.7 0.0 5.6 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC46387.1 - 0.032 12.9 5.4 4.5 5.8 0.0 3.9 2 2 1 3 3 3 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 EFC46387.1 - 0.21 10.3 1.9 25 3.4 0.0 3.6 2 2 1 3 3 3 0 Nup133 N terminal like Ribosomal_L16 PF00252.18 EFC46388.1 - 4.2e-39 133.6 0.2 5.9e-39 133.1 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e UTP15_C PF09384.10 EFC46389.1 - 1.7e-32 112.2 1.9 1.7e-32 112.2 1.9 1.5 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.32 EFC46389.1 - 5e-09 36.7 3.6 0.074 13.9 0.1 5.3 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC46389.1 - 5.5e-05 23.4 0.0 0.048 14.0 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EFC46389.1 - 0.00012 22.3 0.3 0.00012 22.3 0.3 1.9 2 0 0 2 2 2 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 EFC46389.1 - 0.039 12.9 0.0 0.17 10.8 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Flavodoxin_1 PF00258.25 EFC46390.1 - 1.7e-18 67.2 0.1 2e-18 67.0 0.1 1.0 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_NdrI PF07972.11 EFC46390.1 - 0.00076 19.6 0.2 0.0011 19.1 0.2 1.3 1 0 0 1 1 1 1 NrdI Flavodoxin like zinc_ribbon_13 PF09855.9 EFC46390.1 - 0.0098 16.0 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Cas_Csx8 PF09657.10 EFC46390.1 - 0.016 14.2 0.8 0.018 14.1 0.8 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Csx8 (Cas_Csx8) Flavodoxin_5 PF12724.7 EFC46390.1 - 0.026 14.7 0.0 0.043 14.1 0.0 1.4 1 1 0 1 1 1 0 Flavodoxin domain Metallophos PF00149.28 EFC46391.1 - 1.9e-05 25.3 3.0 0.00048 20.7 3.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Msap1 PF17077.5 EFC46391.1 - 0.068 12.3 0.4 0.1 11.8 0.4 1.2 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 RdRP PF05183.12 EFC46392.1 - 3.8e-121 405.6 0.0 4.3e-121 405.4 0.0 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase Rax2 PF12768.7 EFC46393.1 - 0.022 14.2 0.3 0.047 13.1 0.3 1.5 1 0 0 1 1 1 0 Cortical protein marker for cell polarity GON PF08685.11 EFC46394.1 - 4.9e-06 26.6 3.4 4.9e-06 26.6 3.4 2.3 2 1 1 3 3 3 1 GON domain Fer4_5 PF12801.7 EFC46394.1 - 0.0031 17.4 0.2 0.0071 16.3 0.2 1.6 1 0 0 1 1 1 1 4Fe-4S binding domain F-box-like PF12937.7 EFC46394.1 - 0.0053 16.6 0.2 0.0053 16.6 0.2 1.6 2 0 0 2 2 2 1 F-box-like Hydin_ADK PF17213.3 EFC46394.1 - 0.024 14.9 0.1 0.035 14.4 0.1 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain F-box PF00646.33 EFC46394.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 F-box domain DUF4405 PF14358.6 EFC46395.1 - 0.0024 18.4 0.2 2.8 8.6 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4405) DUF3561 PF12084.8 EFC46395.1 - 0.1 12.6 4.3 8.6 6.4 0.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3561) DUF1240 PF06836.12 EFC46395.1 - 0.68 10.5 2.9 0.69 10.5 0.7 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1240) DUF4229 PF14012.6 EFC46395.1 - 2.7 8.2 6.6 3.8 7.7 1.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4229) Izumo-Ig PF16706.5 EFC46396.1 - 0.058 13.5 0.2 2.5 8.2 0.0 2.5 2 0 0 2 2 2 0 Izumo-like Immunoglobulin domain Macoilin PF09726.9 EFC46397.1 - 9.7 4.6 21.7 15 4.0 21.7 1.2 1 0 0 1 1 1 0 Macoilin family Methyltr_RsmB-F PF01189.17 EFC46398.1 - 1.3e-21 77.2 0.0 2.1e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Metallophos PF00149.28 EFC46399.1 - 9.3e-15 55.7 0.1 1.7e-14 54.8 0.1 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC46399.1 - 1.5e-11 44.8 0.0 1.1e-10 42.0 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 EFC46399.1 - 2.7e-08 33.5 0.1 1.3e-07 31.2 0.1 2.2 1 1 0 1 1 1 1 Metallophosphoesterase, calcineurin superfamily zf-C2H2_jaz PF12171.8 EFC46401.1 - 9.9e-08 32.1 4.8 2.6e-07 30.7 3.8 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFC46401.1 - 0.0015 18.8 4.2 0.0034 17.7 4.2 1.6 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFC46401.1 - 0.012 15.9 0.4 0.012 15.9 0.4 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 EFC46401.1 - 0.039 14.8 2.2 0.096 13.6 2.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 EFC46401.1 - 0.058 13.5 0.1 0.058 13.5 0.1 2.0 2 0 0 2 2 2 0 Aberrant zinc-finger zf-C2H2 PF00096.26 EFC46401.1 - 0.21 12.1 3.4 0.52 10.9 3.4 1.7 1 1 0 1 1 1 0 Zinc finger, C2H2 type Cript PF10235.9 EFC46401.1 - 0.61 10.7 5.9 0.12 13.0 1.7 2.1 2 1 0 2 2 2 0 Microtubule-associated protein CRIPT RNR_Alpha PF17975.1 EFC46402.1 - 1.2e-44 150.9 0.6 4.2e-44 149.2 0.4 2.1 2 0 0 2 2 2 1 Ribonucleotide reductase alpha domain Ribonuc_red_lgC PF02867.15 EFC46402.1 - 1.2e-14 53.7 0.1 9.2e-05 21.2 0.0 3.5 2 1 0 3 3 3 3 Ribonucleotide reductase, barrel domain EMC3_TMCO1 PF01956.16 EFC46404.1 - 1.3e-34 119.4 1.6 1.8e-34 118.9 1.6 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like FapA PF03961.13 EFC46404.1 - 0.0062 15.2 2.9 0.0075 14.9 2.9 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A PEP_hydrolase PF09370.10 EFC46404.1 - 0.026 13.8 0.1 0.037 13.2 0.1 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like AIF_C PF14721.6 EFC46404.1 - 0.039 14.3 0.7 0.063 13.6 0.7 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Vpu PF00558.19 EFC46404.1 - 0.039 13.7 0.3 0.039 13.7 0.3 2.2 2 0 0 2 2 2 0 Vpu protein DUF4446 PF14584.6 EFC46404.1 - 0.088 12.8 1.5 0.15 12.1 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF948 PF06103.11 EFC46404.1 - 0.12 12.7 0.2 0.36 11.1 0.2 1.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DivIC PF04977.15 EFC46404.1 - 0.16 11.8 11.6 0.48 10.2 1.2 2.2 1 1 1 2 2 2 0 Septum formation initiator DUF5345 PF17280.2 EFC46404.1 - 0.3 11.1 1.7 0.35 10.9 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5345) DUF4407 PF14362.6 EFC46404.1 - 0.39 10.0 3.9 0.63 9.3 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MtrG PF04210.13 EFC46404.1 - 0.5 10.3 0.1 0.5 10.3 0.1 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G CHD5 PF04420.14 EFC46404.1 - 0.6 10.0 3.2 3 7.7 3.2 2.0 1 1 0 1 1 1 0 CHD5-like protein TMPIT PF07851.13 EFC46404.1 - 1.5 8.0 5.2 4.2 6.5 2.9 2.0 2 0 0 2 2 2 0 TMPIT-like protein COG6 PF06419.11 EFC46404.1 - 3.2 5.9 8.4 5.7 5.0 8.4 1.3 1 1 0 1 1 1 0 Conserved oligomeric complex COG6 HalX PF08663.10 EFC46404.1 - 4.9 7.5 6.6 2 8.8 0.6 2.7 3 0 0 3 3 3 0 HalX domain Med9 PF07544.13 EFC46404.1 - 8.9 6.5 11.5 30 4.8 11.5 1.8 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Tub PF01167.18 EFC46405.1 - 3.6e-81 272.5 0.1 5.7e-81 271.8 0.1 1.3 1 0 0 1 1 1 1 Tub family DUF3527 PF12043.8 EFC46405.1 - 0.00013 21.7 0.1 0.0016 18.1 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3527) DUF4327 PF14217.6 EFC46406.1 - 0.019 15.1 0.1 0.036 14.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4327) DUF1492 PF07374.11 EFC46406.1 - 0.058 13.6 0.3 0.098 12.8 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1492) Rad21_Rec8_N PF04825.13 EFC46407.1 - 4e-37 126.7 0.3 8.4e-37 125.7 0.3 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EFC46407.1 - 9.8e-17 60.0 0.0 2.3e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein CNDH2_N PF06278.11 EFC46407.1 - 0.062 13.5 1.6 0.075 13.3 0.1 1.9 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal RasGEF PF00617.19 EFC46408.1 - 3.4e-57 193.5 1.5 3.4e-57 193.5 1.5 2.1 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 EFC46408.1 - 1.3e-23 83.2 1.4 1.3e-23 83.2 1.4 2.8 2 0 0 2 2 2 1 RasGEF N-terminal motif FAM76 PF16046.5 EFC46408.1 - 0.004 16.6 3.4 0.004 16.6 3.4 2.9 3 0 0 3 3 3 1 FAM76 protein NAD_binding_4 PF07993.12 EFC46409.1 - 2.2e-40 138.4 0.2 3.5e-29 101.7 0.0 2.7 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EFC46409.1 - 0.0011 18.2 0.1 0.73 8.9 0.0 2.8 1 1 2 3 3 3 2 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 EFC46409.1 - 0.0017 17.4 0.9 0.026 13.5 0.9 2.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC46409.1 - 0.0027 17.1 0.1 0.75 9.1 0.0 2.8 2 1 1 3 3 3 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC46409.1 - 0.0047 16.4 1.2 0.74 9.2 1.2 3.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family CD45 PF12567.8 EFC46411.1 - 3.4 7.7 8.6 9.3 6.3 1.3 2.7 2 0 0 2 2 2 0 Leukocyte receptor CD45 Zn_clus PF00172.18 EFC46412.1 - 3.4e-07 30.3 8.9 1.3e-06 28.4 8.9 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cauli_DNA-bind PF03310.13 EFC46412.1 - 0.017 15.2 1.7 0.026 14.6 0.2 2.1 3 0 0 3 3 3 0 Caulimovirus DNA-binding protein DTHCT PF08070.11 EFC46412.1 - 9.1 7.1 10.3 0.94 10.2 4.1 2.2 1 1 1 2 2 2 0 DTHCT (NUC029) region Catalase PF00199.19 EFC46413.1 - 1.3e-148 495.2 0.0 1.7e-148 494.8 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 EFC46413.1 - 9.5e-14 51.4 0.6 2.4e-13 50.1 0.3 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive Lipocalin_8 PF16585.5 EFC46414.1 - 0.44 11.0 5.3 1.1 9.8 0.2 3.6 3 1 1 4 4 4 0 Lipocalin-like domain G-alpha PF00503.20 EFC46415.1 - 7e-99 331.3 8.1 8.6e-99 331.0 8.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC46415.1 - 2e-10 40.4 4.0 2.7e-08 33.4 0.2 2.9 2 1 1 3 3 3 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC46415.1 - 0.00038 20.5 2.0 0.46 10.6 0.0 3.1 3 1 0 3 3 3 2 50S ribosome-binding GTPase Roc PF08477.13 EFC46415.1 - 0.0025 18.0 1.8 0.29 11.4 0.0 2.8 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase DUF1247 PF06851.11 EFC46415.1 - 0.029 14.3 0.1 0.055 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1247) MATH PF00917.26 EFC46416.1 - 0.0012 19.0 0.2 0.042 14.0 0.1 2.8 2 0 0 2 2 2 1 MATH domain NHL PF01436.21 EFC46417.1 - 9e-16 57.0 0.1 4.4e-05 23.3 0.1 4.6 4 0 0 4 4 4 3 NHL repeat DUF5128 PF17170.4 EFC46417.1 - 6.5e-09 35.4 0.7 8.1e-08 31.8 0.0 2.4 2 0 0 2 2 2 1 6-bladed beta-propeller SGL PF08450.12 EFC46417.1 - 0.0028 17.3 0.0 0.56 9.7 0.0 2.8 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DIPSY PF11763.8 EFC46417.1 - 0.04 14.1 1.4 1.7 8.8 0.0 3.1 2 1 1 3 3 3 0 Cell-wall adhesin ligand-binding C-terminal TolB_like PF15869.5 EFC46417.1 - 0.07 12.4 0.1 1 8.5 0.0 2.6 2 1 0 2 2 2 0 TolB-like 6-blade propeller-like Nup96 PF12110.8 EFC46417.1 - 0.11 11.6 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Nuclear protein 96 EMP24_GP25L PF01105.24 EFC46418.1 - 1.1e-28 100.4 0.2 1.6e-28 99.9 0.2 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Aldose_epim PF01263.20 EFC46418.1 - 7.7e-05 22.1 0.1 0.00011 21.7 0.1 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase C2 PF00168.30 EFC46421.1 - 0.00023 21.4 0.0 0.00064 20.0 0.0 1.7 2 0 0 2 2 2 1 C2 domain Claudin_2 PF13903.6 EFC46422.1 - 0.001 18.9 1.0 0.001 18.9 1.0 2.8 1 1 0 2 2 1 1 PMP-22/EMP/MP20/Claudin tight junction MgtE PF01769.16 EFC46422.1 - 0.0011 19.3 14.7 0.046 14.1 0.1 2.3 2 0 0 2 2 2 2 Divalent cation transporter DUF2207 PF09972.9 EFC46422.1 - 0.0042 15.9 14.5 0.06 12.1 4.2 2.1 1 1 1 2 2 2 2 Predicted membrane protein (DUF2207) Ctr PF04145.15 EFC46422.1 - 0.0072 17.0 0.9 0.0072 17.0 0.9 2.2 3 0 0 3 3 3 1 Ctr copper transporter family YukC PF10140.9 EFC46422.1 - 0.02 13.8 7.4 0.062 12.1 1.5 2.3 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC LRR19-TM PF15176.6 EFC46422.1 - 0.049 13.6 0.1 0.049 13.6 0.1 3.4 2 1 1 3 3 3 0 Leucine-rich repeat family 19 TM domain DUF4834 PF16118.5 EFC46422.1 - 0.072 14.1 0.8 0.072 14.1 0.8 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Shisa PF13908.6 EFC46422.1 - 1.8 8.7 15.9 1.7 8.8 0.8 3.3 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator DUF2839 PF10999.8 EFC46422.1 - 2.3 8.6 4.0 1.3 9.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) TRIQK PF15168.6 EFC46422.1 - 2.6 8.0 0.0 2.6 8.0 0.0 3.3 3 1 1 4 4 4 0 Triple QxxK/R motif-containing protein family zf-LITAF-like PF10601.9 EFC46422.1 - 4.2 7.7 10.7 20 5.5 0.1 3.4 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain DUF3328 PF11807.8 EFC46422.1 - 8.8 6.0 8.4 1.9 8.2 0.6 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3328) RdRP PF05183.12 EFC46423.1 - 1.5e-84 284.7 1.2 2.4e-84 284.1 1.2 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase Sel1 PF08238.12 EFC46423.1 - 4.7e-06 27.1 10.3 0.14 12.9 0.0 6.4 7 1 0 7 7 7 2 Sel1 repeat TPR_11 PF13414.6 EFC46423.1 - 0.012 15.2 0.1 0.084 12.6 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_8 PF13181.6 EFC46423.1 - 0.19 12.0 1.2 5.3 7.5 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Guanylate_cyc PF00211.20 EFC46424.1 - 9.8e-05 22.0 0.3 0.0014 18.3 0.0 2.3 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Synaptobrevin PF00957.21 EFC46424.1 - 0.0081 15.9 0.2 0.0081 15.9 0.2 2.2 2 0 0 2 2 2 1 Synaptobrevin dCache_1 PF02743.18 EFC46424.1 - 0.022 14.6 1.0 0.045 13.5 1.0 1.6 1 0 0 1 1 1 0 Cache domain TPR_2 PF07719.17 EFC46424.1 - 0.04 14.0 0.1 0.11 12.7 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat NPA PF16469.5 EFC46424.1 - 0.14 12.8 5.3 0.086 13.4 0.6 2.4 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 Cyclophil_like PF04126.13 EFC46425.1 - 3.5e-21 75.2 0.0 8.6e-17 61.1 0.0 2.5 2 0 0 2 2 2 2 Cyclophilin-like Peptidase_M1 PF01433.20 EFC46425.1 - 6.4e-11 42.2 1.6 1.7e-10 40.9 1.6 1.8 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 EFC46425.1 - 3e-07 30.8 12.4 7.8e-05 22.9 12.4 3.4 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain HEAT PF02985.22 EFC46426.1 - 5.6e-20 69.7 3.7 0.0028 17.8 0.0 8.3 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 EFC46426.1 - 1.4e-17 63.9 0.0 0.00011 22.5 0.0 5.1 3 2 1 5 5 5 4 HEAT repeats HEAT_EZ PF13513.6 EFC46426.1 - 3.2e-08 33.9 0.1 0.14 12.7 0.1 5.1 4 1 1 5 5 5 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EFC46426.1 - 0.0083 16.7 0.2 0.66 10.6 0.0 4.0 2 1 2 4 4 4 2 Vacuolar 14 Fab1-binding region Cohesin_HEAT PF12765.7 EFC46426.1 - 0.017 15.4 0.8 0.19 12.1 0.1 3.1 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DUF4042 PF13251.6 EFC46426.1 - 0.076 12.7 0.8 9.4 5.9 0.0 3.8 2 2 0 2 2 2 0 Domain of unknown function (DUF4042) Zn_clus PF00172.18 EFC46428.1 - 3.9e-09 36.5 15.3 7e-09 35.7 15.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med4 PF10018.9 EFC46428.1 - 0.021 14.5 0.4 0.041 13.5 0.4 1.5 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Lipoprotein_7 PF01540.16 EFC46428.1 - 0.048 12.9 0.6 0.093 12.0 0.6 1.4 1 0 0 1 1 1 0 Adhesin lipoprotein LRR_8 PF13855.6 EFC46429.1 - 2.1e-39 133.1 45.1 1.1e-08 34.7 6.5 5.1 1 1 6 7 7 7 7 Leucine rich repeat LRR_6 PF13516.6 EFC46429.1 - 1.9e-28 96.0 25.4 0.00034 20.4 0.1 10.3 10 0 0 10 10 10 9 Leucine Rich repeat LRR_4 PF12799.7 EFC46429.1 - 2.4e-21 75.4 34.4 0.00023 21.5 0.1 7.2 2 1 7 9 9 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46429.1 - 7.3e-13 47.1 11.1 0.89 10.3 0.1 9.8 10 1 0 10 10 10 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC46429.1 - 7e-05 22.4 13.8 0.79 9.2 0.1 3.9 1 1 3 4 4 4 4 Leucine-rich repeat F-box PF00646.33 EFC46429.1 - 0.073 13.0 0.7 0.16 11.9 0.7 1.6 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 EFC46429.1 - 0.074 13.0 0.5 0.15 12.0 0.5 1.4 1 0 0 1 1 1 0 F-box-like Beta_helix PF13229.6 EFC46429.1 - 0.091 12.6 0.0 0.091 12.6 0.0 2.7 2 1 0 2 2 2 0 Right handed beta helix region Pkinase PF00069.25 EFC46430.1 - 6.8e-65 219.1 0.3 4.8e-64 216.3 0.3 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46430.1 - 2.8e-26 92.3 0.4 6.3e-19 68.3 0.1 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 EFC46430.1 - 0.029 13.7 1.2 0.054 12.8 0.6 1.6 1 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_5 PF13893.6 EFC46431.1 - 6.3e-36 122.7 12.7 1.9e-27 95.4 1.1 4.1 3 1 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 EFC46431.1 - 3.1e-31 107.0 0.7 7.7e-09 35.3 0.0 4.3 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC46431.1 - 1.7e-06 27.8 2.9 0.24 11.3 0.1 4.0 4 0 0 4 4 4 3 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EFC46431.1 - 2.7e-06 27.4 0.1 0.025 14.6 0.0 3.4 3 0 0 3 3 3 2 Limkain b1 DUF3439 PF11921.8 EFC46431.1 - 0.0011 18.9 0.5 0.0024 17.8 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Calcipressin PF04847.12 EFC46431.1 - 0.0012 18.7 3.4 1.5 8.5 0.2 3.3 3 0 0 3 3 3 2 Calcipressin RL PF17797.1 EFC46431.1 - 0.012 15.5 0.1 11 6.0 0.0 3.7 4 0 0 4 4 4 0 RL domain IPP-2 PF04979.14 EFC46432.1 - 4.1e-09 37.3 18.4 7.9e-08 33.1 18.4 2.1 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) La PF05383.17 EFC46432.1 - 0.063 13.3 0.3 0.13 12.4 0.3 1.5 1 0 0 1 1 1 0 La domain Acetyltransf_CG PF14542.6 EFC46433.1 - 1.2e-22 79.8 0.1 1.6e-22 79.4 0.1 1.2 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase KaiA PF07688.12 EFC46434.1 - 0.52 10.5 7.6 0.24 11.6 0.5 2.8 2 0 0 2 2 2 0 KaiA C-terminal domain Gcd10p PF04189.13 EFC46435.1 - 5.8e-66 222.6 0.3 7.5e-66 222.3 0.3 1.1 1 0 0 1 1 1 1 Gcd10p family TipE PF16972.5 EFC46435.1 - 0.11 11.6 0.2 0.17 11.0 0.2 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE DUF4346 PF14251.6 EFC46435.1 - 0.15 12.1 0.3 0.29 11.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4346) HECT PF00632.25 EFC46436.1 - 5e-41 141.2 1.7 5e-41 141.2 1.7 2.5 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 EFC46436.1 - 3.6e-32 111.8 2.3 3.6e-32 111.8 2.3 3.2 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46436.1 - 7.9e-18 64.7 0.2 2.6e-17 63.0 0.2 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC46436.1 - 0.0018 17.7 0.0 0.0042 16.5 0.0 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Avl9 PF09794.9 EFC46437.1 - 5.3e-06 25.4 0.0 2.3e-05 23.3 0.0 2.1 2 1 0 2 2 2 1 Transport protein Avl9 Afi1 PF07792.12 EFC46437.1 - 0.00031 21.2 0.0 0.00031 21.2 0.0 2.7 2 1 1 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 EFC46437.1 - 0.0031 17.4 0.0 0.012 15.6 0.0 2.1 1 0 0 1 1 1 1 Stabilization of polarity axis EamA PF00892.20 EFC46438.1 - 5.8e-15 55.7 19.1 3.7e-08 33.6 0.8 2.3 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EFC46438.1 - 3.9e-09 35.9 7.8 6.4e-08 31.9 1.7 2.2 1 1 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Nuc_sug_transp PF04142.15 EFC46438.1 - 3.5e-08 33.0 0.0 1e-07 31.5 0.0 1.6 1 1 1 2 2 2 1 Nucleotide-sugar transporter TPT PF03151.16 EFC46438.1 - 1.4e-05 24.6 4.0 2.7e-05 23.7 4.0 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EFC46438.1 - 1.5e-05 24.3 4.2 2e-05 23.9 4.2 1.1 1 0 0 1 1 1 1 UAA transporter family SLC35F PF06027.12 EFC46438.1 - 0.00023 20.8 15.4 0.00078 19.0 15.4 1.7 1 1 0 1 1 1 1 Solute carrier family 35 TMEM234 PF10639.9 EFC46438.1 - 0.00033 20.7 0.4 0.0059 16.6 0.0 2.5 2 0 0 2 2 2 1 Putative transmembrane family 234 PUNUT PF16913.5 EFC46438.1 - 0.017 14.4 7.8 0.04 13.1 7.8 1.7 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport RCC1 PF00415.18 EFC46439.1 - 2.4e-13 50.5 0.5 5.9e-07 30.0 0.0 2.8 2 1 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46439.1 - 9.1e-10 38.1 1.1 5.9e-08 32.3 0.0 3.0 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC46439.1 - 5.5e-08 33.0 3.9 1.2e-07 31.9 2.1 2.5 2 1 0 2 2 2 1 BTB/POZ domain Ala_racemase_N PF01168.20 EFC46440.1 - 1.2e-20 74.1 0.0 1.7e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 EFC46440.1 - 3.2e-17 63.0 0.0 6.9e-17 61.9 0.0 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain SAM_MT PF04445.13 EFC46441.1 - 3.2e-31 108.5 0.0 2.1e-26 92.8 0.0 2.0 2 0 0 2 2 2 2 Putative SAM-dependent methyltransferase Ank_3 PF13606.6 EFC46442.1 - 0.00069 19.9 1.1 3.3 8.6 0.0 4.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 EFC46442.1 - 0.0071 16.9 0.6 0.13 12.9 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Casc1_N PF15927.5 EFC46442.1 - 0.11 12.2 0.1 0.46 10.1 0.1 2.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Ank_4 PF13637.6 EFC46442.1 - 0.12 13.0 0.0 1.7e+02 3.0 0.0 4.2 3 0 0 3 3 3 0 Ankyrin repeats (many copies) HCMV_UL139 PF12507.8 EFC46443.1 - 0.14 12.5 1.7 0.28 11.6 0.1 2.3 3 0 0 3 3 3 0 Human Cytomegalovirus UL139 protein Macoilin PF09726.9 EFC46443.1 - 0.2 10.2 10.1 0.21 10.1 9.6 1.3 1 1 0 1 1 1 0 Macoilin family Phage_integrase PF00589.22 EFC46444.1 - 0.00013 21.8 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family G-alpha PF00503.20 EFC46447.1 - 4.4e-54 184.0 9.5 5.8e-54 183.6 9.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC46447.1 - 1.2e-08 34.6 0.5 0.00019 20.9 0.0 3.1 3 0 0 3 3 3 2 ADP-ribosylation factor family SRPRB PF09439.10 EFC46447.1 - 0.0018 17.8 0.1 0.011 15.2 0.0 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EFC46447.1 - 0.0027 18.2 0.0 0.0076 16.8 0.0 1.8 2 0 0 2 2 2 1 ABC transporter GTP_EFTU PF00009.27 EFC46447.1 - 0.0031 17.1 0.1 0.069 12.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC46447.1 - 0.004 17.2 0.1 0.067 13.3 0.1 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 EFC46447.1 - 0.005 17.0 0.1 0.039 14.2 0.0 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EFC46447.1 - 0.015 15.3 0.0 0.028 14.3 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 EFC46447.1 - 0.015 15.1 0.4 0.035 13.8 0.1 1.8 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 EFC46447.1 - 0.019 14.5 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B cobW PF02492.19 EFC46447.1 - 0.055 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 EFC46447.1 - 0.18 12.3 0.0 0.18 12.3 0.0 2.2 2 1 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFC46448.1 - 9e-68 229.0 1.3 1.1e-67 228.7 1.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC46448.1 - 9.1e-08 31.8 0.1 0.003 17.1 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Ras PF00071.22 EFC46448.1 - 7.6e-06 25.6 0.2 0.12 12.0 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC46448.1 - 1.2e-05 25.6 0.0 0.0083 16.3 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC46448.1 - 4.4e-05 23.0 0.2 0.097 12.1 0.0 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC46448.1 - 0.00014 21.3 1.1 0.023 14.1 0.2 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC46448.1 - 0.0027 17.8 0.1 0.58 10.3 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC46448.1 - 0.0051 16.4 0.1 0.87 9.1 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFC46448.1 - 0.013 15.3 0.1 0.064 13.0 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 EFC46448.1 - 0.062 13.3 0.0 0.27 11.3 0.0 2.1 1 1 0 1 1 1 0 Dynamin family NB-ARC PF00931.22 EFC46448.1 - 0.073 12.2 0.0 0.16 11.1 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain LRS4 PF10422.9 EFC46448.1 - 0.097 12.2 1.5 0.18 11.3 1.5 1.4 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DHC_N1 PF08385.12 EFC46448.1 - 0.4 9.3 6.9 4.4 5.8 3.5 2.4 2 1 0 2 2 2 0 Dynein heavy chain, N-terminal region 1 Myb_DNA-binding PF00249.31 EFC46449.1 - 1.6e-48 162.7 8.7 7e-19 67.8 0.2 3.0 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC46449.1 - 2.3e-40 136.6 9.4 1.9e-20 72.8 0.4 3.0 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC46449.1 - 6.8e-08 32.3 0.2 0.004 17.0 0.0 2.9 1 1 2 3 3 3 2 Myb DNA-binding like SLIDE PF09111.10 EFC46449.1 - 3.2e-06 27.1 0.1 0.041 13.9 0.0 3.0 1 1 1 3 3 3 2 SLIDE MADF_DNA_bdg PF10545.9 EFC46449.1 - 0.00028 21.1 1.2 0.58 10.5 0.2 3.1 3 0 0 3 3 3 1 Alcohol dehydrogenase transcription factor Myb/SANT-like SANT_DAMP1_like PF16282.5 EFC46449.1 - 0.00066 19.8 0.5 0.27 11.4 0.1 2.3 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 Spore_III_AB PF09548.10 EFC46449.1 - 0.0013 18.8 0.2 0.39 10.8 0.0 2.1 1 1 1 2 2 2 2 Stage III sporulation protein AB (spore_III_AB) Myb_DNA-bind_4 PF13837.6 EFC46449.1 - 0.014 15.7 11.0 4.2 7.8 0.2 4.6 3 2 0 3 3 3 0 Myb/SANT-like DNA-binding domain Bac_globin PF01152.21 EFC46449.1 - 0.12 12.5 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial-like globin Myb_DNA-bind_2 PF08914.11 EFC46449.1 - 0.14 12.3 3.5 4.1 7.7 0.1 3.3 1 1 2 3 3 3 0 Rap1 Myb domain GPR_Gpa2_C PF11970.8 EFC46450.1 - 5.8 7.1 7.5 2.6 8.2 3.4 2.5 2 2 1 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term LRR_6 PF13516.6 EFC46451.1 - 1.1e-36 121.7 13.3 2.5e-05 24.0 0.0 8.0 8 0 0 8 8 8 6 Leucine Rich repeat LRR_8 PF13855.6 EFC46451.1 - 1.3e-18 66.5 8.0 3.3e-08 33.2 0.7 4.1 3 1 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC46451.1 - 1.8e-17 63.2 10.0 0.00024 21.4 0.4 5.1 2 2 5 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46451.1 - 4.6e-10 38.6 4.3 2.3 9.1 0.1 6.9 8 0 0 8 8 8 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC46451.1 - 3.9e-08 33.0 4.2 0.0012 18.4 0.8 2.5 1 1 1 2 2 2 2 Leucine-rich repeat CLU_N PF15044.6 EFC46451.1 - 4e-06 27.1 1.8 1.5 9.2 0.2 4.4 4 1 0 4 4 4 3 Mitochondrial function, CLU-N-term DUF4347 PF14252.6 EFC46451.1 - 8.4e-05 22.5 0.4 8.5 6.2 0.0 4.6 1 1 2 4 4 4 2 Domain of unknown function (DUF4347) HydF_dimer PF18128.1 EFC46451.1 - 0.076 13.1 1.7 42 4.3 0.1 3.5 2 2 1 3 3 3 0 Hydrogen maturase F dimerization domain F-box-like PF12937.7 EFC46451.1 - 0.1 12.5 0.3 0.17 11.8 0.3 1.3 1 0 0 1 1 1 0 F-box-like UPF0193 PF05250.11 EFC46451.1 - 4.3 7.1 6.8 0.44 10.3 1.0 2.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0193) UQ_con PF00179.26 EFC46452.1 - 1.5e-13 50.6 1.4 9.8e-12 44.7 0.5 2.5 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme F-box-like PF12937.7 EFC46452.1 - 2.3e-07 30.6 0.0 6.4e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC46452.1 - 0.00026 20.8 0.3 0.00092 19.0 0.3 2.0 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 EFC46452.1 - 0.19 12.1 0.1 0.19 12.1 0.1 3.0 2 1 1 3 3 3 0 PRANC domain DUF4442 PF14539.6 EFC46453.1 - 1.7e-20 73.5 0.0 2.1e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) PH PF00169.29 EFC46454.1 - 2.3e-17 63.4 1.4 1.2e-16 61.1 0.2 2.9 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 EFC46454.1 - 3.1e-06 27.5 1.6 3.1e-06 27.5 1.6 3.6 2 1 0 2 2 2 1 Pleckstrin homology domain GRAM PF02893.20 EFC46454.1 - 5.8e-06 26.2 0.1 0.00012 22.0 0.0 3.0 2 0 0 2 2 2 1 GRAM domain PH_9 PF15410.6 EFC46454.1 - 0.16 12.3 1.1 0.65 10.4 0.3 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain CARM1 PF11531.8 EFC46454.1 - 0.22 11.7 1.2 27 5.0 0.2 2.8 2 0 0 2 2 2 0 Coactivator-associated arginine methyltransferase 1 N terminal RRM_1 PF00076.22 EFC46455.1 - 1e-75 249.5 9.9 8.7e-20 70.3 0.1 5.5 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC46455.1 - 8.7e-11 41.5 10.3 0.00032 20.3 0.1 6.1 6 1 1 7 7 7 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC46455.1 - 6.3e-06 26.0 0.2 0.11 12.4 0.0 4.7 5 0 0 5 5 5 1 Occluded RNA-recognition motif RRM_2 PF04059.12 EFC46455.1 - 8.5e-05 22.7 0.9 3.2 8.0 0.0 4.4 4 0 0 4 4 4 1 RNA recognition motif 2 RRM_Rrp7 PF17799.1 EFC46455.1 - 0.00074 19.4 6.8 5.6 6.7 1.4 4.7 3 1 0 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 EFC46455.1 - 0.00074 19.6 0.3 2.7 8.2 0.0 4.5 5 0 0 5 5 5 1 RNA recognition motif Limkain-b1 PF11608.8 EFC46455.1 - 0.0025 17.9 0.0 1.1 9.4 0.1 3.7 3 0 0 3 3 3 1 Limkain b1 Nup35_RRM_2 PF14605.6 EFC46455.1 - 0.0036 17.2 0.8 20 5.3 0.0 4.6 5 0 0 5 5 5 0 Nup53/35/40-type RNA recognition motif XS PF03468.14 EFC46455.1 - 0.25 11.7 9.2 0.2 12.0 0.2 4.0 5 0 0 5 5 5 0 XS domain RPA43_OB PF17875.1 EFC46455.1 - 7.9 7.1 9.2 14 6.3 0.8 2.9 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Dpy-30 PF05186.13 EFC46456.1 - 9.2e-11 41.3 0.1 1.4e-10 40.7 0.1 1.3 1 0 0 1 1 1 1 Dpy-30 motif DUF5401 PF17380.2 EFC46456.1 - 5.5 4.9 21.1 6.9 4.6 21.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) U1snRNP70_N PF12220.8 EFC46456.1 - 8.4 7.1 14.6 0.12 13.0 1.7 2.4 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Adaptin_N PF01602.20 EFC46457.1 - 3.7e-49 167.7 26.7 1.1e-48 166.2 26.7 1.7 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 EFC46457.1 - 0.00039 20.7 0.2 1.2 9.5 0.0 3.6 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 EFC46457.1 - 0.0054 16.9 0.0 0.064 13.5 0.0 2.8 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 EFC46457.1 - 0.04 14.4 0.0 1.7 9.2 0.0 2.7 2 0 0 2 2 2 0 HEAT-like repeat LRR_6 PF13516.6 EFC46458.1 - 6.7e-42 138.0 23.6 0.00021 21.1 0.2 12.3 14 0 0 14 14 14 10 Leucine Rich repeat LRR_8 PF13855.6 EFC46458.1 - 1.2e-29 101.9 21.3 9.4e-07 28.5 2.3 6.3 5 1 1 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC46458.1 - 1.4e-20 73.0 35.0 0.0043 17.4 1.0 8.7 3 1 8 12 12 12 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC46458.1 - 6.3e-12 45.3 2.9 0.025 14.1 0.2 4.3 1 1 3 4 4 4 4 Leucine-rich repeat Helveticin_J PF17312.2 EFC46458.1 - 0.0002 20.6 2.5 0.43 9.7 0.0 3.9 3 1 1 4 4 4 2 Bacteriocin helveticin-J LRR_1 PF00560.33 EFC46458.1 - 0.0031 17.8 21.3 46 5.1 0.1 9.7 9 4 0 9 9 9 0 Leucine Rich Repeat Nitrophorin PF02087.15 EFC46458.1 - 0.005 16.9 0.5 27 4.7 0.0 3.8 2 2 1 4 4 4 0 Nitrophorin Post_transc_reg PF13797.6 EFC46458.1 - 0.03 14.2 0.4 1.5 8.7 0.0 3.2 3 0 0 3 3 3 0 Post-transcriptional regulator DSPc PF00782.20 EFC46459.1 - 1.7e-28 99.1 0.4 2.3e-28 98.7 0.4 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EFC46459.1 - 0.055 13.8 0.0 0.078 13.3 0.0 1.2 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFC46459.1 - 0.11 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF1127 PF06568.11 EFC46459.1 - 0.17 11.7 1.3 0.21 11.4 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) RicinB_lectin_2 PF14200.6 EFC46460.1 - 2.9e-05 24.7 6.2 0.001 19.8 0.0 4.2 2 1 3 5 5 5 1 Ricin-type beta-trefoil lectin domain-like mRNA_triPase PF02940.15 EFC46460.1 - 0.0091 15.7 1.2 0.0091 15.7 1.2 2.1 2 0 0 2 2 2 1 mRNA capping enzyme, beta chain PhoLip_ATPase_C PF16212.5 EFC46461.1 - 1.3e-85 287.1 21.7 1.3e-85 287.1 21.7 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC46461.1 - 3.6e-27 93.9 4.6 9.2e-27 92.5 4.6 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFC46461.1 - 1.6e-10 40.9 0.0 2.1e-09 37.3 0.0 2.7 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC46461.1 - 7.8e-10 39.4 1.2 3.4e-05 24.2 0.7 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 EFC46461.1 - 8.1e-10 38.5 0.0 2.3e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 EFC46461.1 - 0.0043 16.8 0.2 0.02 14.7 0.1 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase LRR_6 PF13516.6 EFC46462.1 - 3.2e-53 173.3 28.7 0.00038 20.3 0.1 16.4 15 1 1 16 16 16 13 Leucine Rich repeat LRR_8 PF13855.6 EFC46462.1 - 1e-33 114.9 24.1 8.2e-10 38.3 0.9 7.2 5 2 4 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 EFC46462.1 - 4e-24 84.3 40.6 0.00012 22.4 2.6 10.0 2 2 13 15 15 15 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC46462.1 - 1.6e-11 44.0 14.0 0.018 14.6 0.3 6.1 2 1 5 7 7 7 5 Leucine-rich repeat LRR_1 PF00560.33 EFC46462.1 - 2e-09 36.7 17.5 7.2 7.6 0.0 11.5 12 1 0 12 12 12 2 Leucine Rich Repeat F-box-like PF12937.7 EFC46462.1 - 3.9e-05 23.5 0.0 8.7e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC46462.1 - 0.0021 17.9 0.1 0.0062 16.4 0.1 1.8 2 0 0 2 2 2 1 F-box domain Acetyltransf_19 PF18015.1 EFC46462.1 - 0.028 14.6 1.7 13 6.1 0.0 3.8 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain Apo-VLDL-II PF05418.11 EFC46462.1 - 0.028 15.0 0.0 19 5.9 0.0 4.4 4 1 1 5 5 5 0 Apovitellenin I (Apo-VLDL-II) Methyltransf_10 PF05971.12 EFC46463.1 - 5.5e-54 183.5 7.9 2.2e-52 178.2 7.9 2.9 1 1 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 EFC46463.1 - 0.009 15.6 0.0 2 7.9 0.0 2.2 1 1 1 2 2 2 2 Methyltransferase small domain PrmA PF06325.13 EFC46463.1 - 0.0093 15.4 0.1 0.019 14.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 EFC46463.1 - 0.022 14.7 0.0 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 EFC46463.1 - 0.026 14.3 0.1 0.043 13.6 0.1 1.7 1 1 0 1 1 1 0 Methyltransferase domain Erf4 PF10256.9 EFC46463.1 - 0.09 12.9 0.3 0.22 11.6 0.3 1.6 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family SPATA1_C PF15743.5 EFC46463.1 - 0.11 12.6 1.3 0.18 11.9 1.3 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus NGF PF00243.18 EFC46465.1 - 0.00035 20.8 1.3 0.00047 20.4 0.4 1.7 1 1 1 2 2 2 1 Nerve growth factor family NAD_binding_8 PF13450.6 EFC46466.1 - 1.7e-08 34.6 0.0 5.3e-08 33.0 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 EFC46466.1 - 3.4e-06 26.5 0.0 2.5e-05 23.6 0.0 2.1 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 EFC46466.1 - 8.3e-06 25.2 0.0 0.021 14.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC46466.1 - 0.00078 19.1 0.4 0.031 13.9 0.2 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 EFC46466.1 - 0.0016 17.6 0.6 0.03 13.4 0.3 2.1 2 0 0 2 2 2 1 FAD binding domain GMC_oxred_N PF00732.19 EFC46466.1 - 0.0033 16.8 0.0 0.32 10.3 0.0 2.4 2 0 0 2 2 2 1 GMC oxidoreductase Lycopene_cycl PF05834.12 EFC46466.1 - 0.1 11.6 0.3 0.2 10.6 0.1 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 EFC46466.1 - 0.12 11.2 0.3 0.36 9.6 0.1 1.8 2 0 0 2 2 2 0 Tryptophan halogenase Pyr_redox PF00070.27 EFC46466.1 - 0.16 12.5 0.2 9.7 6.8 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC46466.1 - 0.17 11.1 0.3 0.38 10.0 0.3 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase zf-CCCH PF00642.24 EFC46467.1 - 8.2e-07 28.8 6.8 0.0078 16.1 1.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFC46467.1 - 5e-05 24.0 2.6 0.11 13.2 0.3 2.3 2 0 0 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 EFC46467.1 - 0.00018 21.4 11.3 0.018 15.1 2.7 2.9 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 EFC46467.1 - 0.43 10.4 8.2 0.12 12.2 1.8 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger Zip PF02535.22 EFC46468.1 - 3.4 6.8 4.1 4.7 6.3 4.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter AP3D1 PF06375.11 EFC46468.1 - 5.5 7.2 14.8 1.4 9.2 1.4 2.2 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 ATG27 PF09451.10 EFC46470.1 - 4.5e-13 49.7 0.0 5.7e-13 49.3 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 EFC46470.1 - 2e-08 33.6 0.0 3.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor Claudin_3 PF06653.11 EFC46470.1 - 0.075 13.0 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Tight junction protein, Claudin-like CIMR PF00878.18 EFC46470.1 - 0.092 12.8 0.2 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat MFS_1 PF07690.16 EFC46471.1 - 7.7e-19 67.8 15.7 7.7e-19 67.8 15.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Ras PF00071.22 EFC46472.1 - 1.1e-08 34.8 0.0 2.3e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 Ras family Arf PF00025.21 EFC46472.1 - 1.9e-07 30.7 0.0 4e-07 29.7 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC46472.1 - 1.2e-05 25.5 0.0 2.7e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 EFC46472.1 - 0.022 14.7 0.1 0.065 13.1 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MecA_N PF05223.11 EFC46472.1 - 0.11 12.8 0.1 0.23 11.7 0.1 1.5 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain LRR_6 PF13516.6 EFC46473.1 - 3.2e-34 114.1 29.0 0.00022 21.0 0.0 12.1 13 0 0 13 13 13 9 Leucine Rich repeat LRR_8 PF13855.6 EFC46473.1 - 3.4e-28 97.2 35.1 1.5e-09 37.5 2.7 5.8 3 1 5 8 8 8 6 Leucine rich repeat LRR_4 PF12799.7 EFC46473.1 - 2.9e-24 84.7 23.6 1e-05 25.7 0.1 8.2 3 1 5 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46473.1 - 9.8e-18 62.0 12.1 0.16 12.6 0.1 10.7 11 0 0 11 11 11 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC46473.1 - 7.7e-06 25.5 2.4 0.12 11.9 0.1 3.2 1 1 1 3 3 3 2 Leucine-rich repeat LRR_5 PF13306.6 EFC46473.1 - 0.00073 19.5 4.9 0.017 15.1 2.4 2.5 1 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Beta_helix PF13229.6 EFC46473.1 - 0.047 13.5 9.2 0.098 12.5 9.2 1.7 1 1 0 1 1 1 0 Right handed beta helix region HTH_34 PF13601.6 EFC46473.1 - 0.18 12.0 2.7 0.44 10.8 0.2 2.6 3 0 0 3 3 3 0 Winged helix DNA-binding domain NHL PF01436.21 EFC46474.1 - 8.6e-16 57.1 1.8 3.4e-05 23.6 0.1 4.6 4 0 0 4 4 4 4 NHL repeat DUF5128 PF17170.4 EFC46474.1 - 0.00019 20.7 0.6 0.0017 17.6 0.2 2.3 1 1 1 2 2 2 1 6-bladed beta-propeller Arylesterase PF01731.20 EFC46474.1 - 0.0017 18.5 0.2 3.2 8.0 0.0 3.5 4 0 0 4 4 4 2 Arylesterase Lactonase PF10282.9 EFC46474.1 - 0.093 12.0 0.0 12 5.0 0.0 2.9 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller PrmA PF06325.13 EFC46475.1 - 1.2e-08 34.7 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EFC46475.1 - 5e-08 33.5 0.0 1.7e-07 31.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 EFC46475.1 - 2.5e-07 30.7 0.1 3.8e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_11 PF08241.12 EFC46475.1 - 4.9e-07 30.3 0.0 3e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFC46475.1 - 1.4e-05 24.7 0.0 2.6e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 EFC46475.1 - 5.2e-05 23.2 0.0 9.3e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC46475.1 - 0.00021 21.1 0.0 0.00096 19.0 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC46475.1 - 0.00021 21.1 0.0 0.0011 18.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EFC46475.1 - 0.00036 20.4 0.0 0.00067 19.5 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase GidB PF02527.15 EFC46475.1 - 0.0052 16.1 0.0 0.0094 15.3 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G DOT1 PF08123.13 EFC46475.1 - 0.006 16.1 0.2 0.022 14.3 0.0 1.8 2 0 0 2 2 2 1 Histone methylation protein DOT1 FtsJ PF01728.19 EFC46475.1 - 0.0094 16.1 0.0 0.035 14.2 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 EFC46475.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_24 PF13578.6 EFC46475.1 - 0.017 16.1 0.0 0.032 15.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 EFC46475.1 - 0.02 13.9 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Bud13 PF09736.9 EFC46476.1 - 5.9e-38 130.5 13.8 5.9e-38 130.5 13.8 2.9 2 1 1 3 3 3 1 Pre-mRNA-splicing factor of RES complex Inositol_P PF00459.25 EFC46476.1 - 0.19 11.2 2.9 0.31 10.5 2.8 1.4 1 1 0 1 1 1 0 Inositol monophosphatase family Fe_hyd_lg_C PF02906.14 EFC46476.1 - 0.25 11.0 2.3 0.38 10.4 2.3 1.2 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain KIAA1430 PF13879.6 EFC46477.1 - 3.4e-05 24.6 1.4 3.4e-05 24.6 1.4 2.8 2 1 1 3 3 3 1 KIAA1430 homologue Mucin PF01456.17 EFC46477.1 - 0.008 16.2 14.3 0.013 15.5 14.3 1.4 1 0 0 1 1 1 1 Mucin-like glycoprotein Merozoite_SPAM PF07133.11 EFC46477.1 - 0.15 12.0 29.0 0.048 13.7 25.0 2.0 1 1 1 2 2 2 0 Merozoite surface protein (SPAM) Chordopox_G3 PF06129.12 EFC46477.1 - 0.29 11.9 5.4 0.074 13.8 2.0 1.7 2 0 0 2 2 2 0 Chordopoxvirus G3 protein SSP160 PF06933.11 EFC46477.1 - 1.1 7.4 11.8 1.4 7.0 11.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Laminin_G_3 PF13385.6 EFC46478.1 - 4.4e-16 59.4 0.1 2.5e-11 44.0 0.0 2.5 2 0 0 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily RGS PF00615.19 EFC46478.1 - 2.6e-10 40.6 2.6 1.3e-09 38.4 0.7 2.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain C2 PF00168.30 EFC46478.1 - 2.9e-10 40.3 0.0 6.1e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ras PF00071.22 EFC46479.1 - 6.7e-16 58.3 0.0 8e-13 48.3 0.0 2.6 1 1 0 2 2 2 2 Ras family Roc PF08477.13 EFC46479.1 - 4.2e-06 27.0 0.4 0.13 12.5 0.1 2.9 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC46479.1 - 0.014 14.8 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_18 PF13238.6 EFC46479.1 - 0.17 12.5 0.5 0.99 10.0 0.0 2.2 2 1 1 3 3 3 0 AAA domain AAA_23 PF13476.6 EFC46479.1 - 0.18 12.3 2.9 1.4 9.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain OGG_N PF07934.12 EFC46479.1 - 0.3 11.2 2.7 1 9.5 1.5 2.1 2 1 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain Guanylate_cyc PF00211.20 EFC46480.1 - 1.1e-05 25.1 0.0 6.7e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain QIL1 PF15884.5 EFC46480.1 - 0.022 15.3 0.8 5.8 7.6 0.0 3.8 3 1 1 4 4 4 0 MICOS complex subunit MIC13, QIL1 FtsX PF02687.21 EFC46480.1 - 0.081 13.4 2.6 2 9.0 0.1 2.8 2 0 0 2 2 2 0 FtsX-like permease family LapA_dom PF06305.11 EFC46480.1 - 2.8 7.8 4.5 19 5.1 0.7 2.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF4116 PF13475.6 EFC46481.1 - 9e-145 470.3 21.1 4.6e-19 67.9 0.2 12.5 6 2 7 14 14 14 13 Domain of unknown function (DUF4116) Hyphal_reg_CWP PF11765.8 EFC46481.1 - 2.5e-05 23.4 4.6 0.057 12.4 0.3 3.3 1 1 3 4 4 4 3 Hyphally regulated cell wall protein N-terminal CbiG_C PF01890.16 EFC46481.1 - 0.00023 21.7 9.8 38 4.9 0.1 6.6 3 2 4 7 7 7 0 Cobalamin synthesis G C-terminus DUF1757 PF08560.10 EFC46481.1 - 0.05 13.7 0.8 6.5 6.8 0.0 3.7 2 2 2 4 4 4 0 Protein of unknown function (DUF1757) AfsA PF03756.13 EFC46481.1 - 0.11 12.4 0.6 5.3 7.0 0.0 3.7 3 2 1 4 4 4 0 A-factor biosynthesis hotdog domain SpoU_sub_bind PF08032.12 EFC46481.1 - 0.18 12.1 16.3 2.7 8.3 0.5 5.8 6 2 1 7 7 7 0 RNA 2'-O ribose methyltransferase substrate binding GST_C PF00043.25 EFC46481.1 - 0.28 11.4 7.7 7.9 6.8 0.1 4.8 3 2 0 5 5 5 0 Glutathione S-transferase, C-terminal domain DUF1667 PF07892.11 EFC46481.1 - 0.32 11.1 2.4 35 4.5 0.0 4.1 4 1 1 5 5 5 0 Protein of unknown function (DUF1667) Innexin PF00876.18 EFC46481.1 - 0.53 9.5 10.1 6.6 5.9 0.4 4.7 2 2 1 3 3 3 0 Innexin DUF2389 PF09493.10 EFC46481.1 - 7.1 7.4 9.3 89 3.8 0.1 5.4 5 1 2 7 7 7 0 Tryptophan-rich protein (DUF2389) SAP30_Sin3_bdg PF13867.6 EFC46482.1 - 1.9e-07 31.3 0.7 5.9e-07 29.7 0.7 1.8 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 SDA1 PF05285.12 EFC46482.1 - 0.16 11.3 6.2 0.28 10.6 6.2 1.3 1 0 0 1 1 1 0 SDA1 Peptidase_S58 PF03576.14 EFC46483.1 - 1e-19 71.2 0.0 1.4e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family S58 Streptin-Immun PF11083.8 EFC46483.1 - 0.14 12.5 0.7 0.76 10.2 0.4 2.0 1 1 1 2 2 2 0 Lantibiotic streptin immunity protein PCI PF01399.27 EFC46484.1 - 4.1e-16 59.4 0.6 4.1e-16 59.4 0.6 1.8 2 0 0 2 2 2 1 PCI domain Osmo_CC PF08946.10 EFC46484.1 - 0.038 14.2 0.0 0.97 9.7 0.0 2.8 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DUF1955 PF09205.10 EFC46484.1 - 0.21 11.3 3.0 1.2 8.8 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1955) Hydrolase_4 PF12146.8 EFC46485.1 - 1.1e-13 51.0 0.0 3e-06 26.7 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 EFC46485.1 - 1.1e-08 35.1 0.0 3.6e-08 33.5 0.0 1.7 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 EFC46485.1 - 2.8e-06 27.0 0.0 9.4e-05 22.0 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 EFC46485.1 - 7.2e-06 25.8 0.1 0.095 12.3 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Asp2 PF16929.5 EFC46485.1 - 0.00032 19.8 0.0 0.00064 18.8 0.0 1.4 1 0 0 1 1 1 1 Accessory Sec system GspB-transporter DLH PF01738.18 EFC46485.1 - 0.00075 19.1 0.0 0.002 17.7 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 EFC46485.1 - 0.00075 20.2 0.0 0.0088 16.7 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Acyl_transf_2 PF02273.15 EFC46485.1 - 0.0015 17.9 0.0 0.0027 17.0 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase BAAT_C PF08840.11 EFC46485.1 - 0.013 15.4 0.1 1.6 8.6 0.0 2.7 1 1 1 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 EFC46485.1 - 0.014 15.1 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 EFC46485.1 - 0.031 14.4 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein LIP PF03583.14 EFC46485.1 - 0.11 11.8 0.1 0.75 9.1 0.0 2.0 2 0 0 2 2 2 0 Secretory lipase HOOK PF05622.12 EFC46486.1 - 0.024 12.8 36.8 0.01 14.0 16.7 2.5 1 1 1 2 2 2 0 HOOK protein FAM184 PF15665.5 EFC46486.1 - 0.077 12.8 35.5 1.4 8.7 14.9 2.8 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B MscS_porin PF12795.7 EFC46486.1 - 0.092 12.3 25.8 0.35 10.4 16.6 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DUF4407 PF14362.6 EFC46486.1 - 0.2 10.9 19.8 13 5.1 19.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) GAS PF13851.6 EFC46486.1 - 0.58 9.5 39.0 0.14 11.5 16.9 2.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 EFC46486.1 - 0.81 9.8 36.1 0.17 12.0 15.3 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Macoilin PF09726.9 EFC46486.1 - 0.91 8.0 33.5 15 4.0 33.4 1.9 1 1 0 1 1 1 0 Macoilin family HAUS-augmin3 PF14932.6 EFC46486.1 - 0.97 9.0 29.2 0.3 10.6 8.5 2.3 1 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 5_nucleotid PF05761.14 EFC46486.1 - 1.8 7.3 16.7 0.17 10.8 6.0 2.1 2 0 0 2 2 2 0 5' nucleotidase family Sec23_helical PF04815.15 EFC46486.1 - 2.8 7.8 6.2 4.8 7.0 3.6 2.6 2 1 0 2 2 2 0 Sec23/Sec24 helical domain Baculo_PEP_C PF04513.12 EFC46486.1 - 4.3 7.4 14.7 2.8 8.0 0.8 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Snapin_Pallidin PF14712.6 EFC46486.1 - 4.5 7.8 27.9 4.4 7.8 2.7 3.6 2 1 1 4 4 4 0 Snapin/Pallidin Sulfatase_C PF14707.6 EFC46486.1 - 7.7 7.3 10.8 0.7 10.6 0.9 3.2 1 1 2 3 3 3 0 C-terminal region of aryl-sulfatase COG5 PF10392.9 EFC46486.1 - 9.7 6.4 17.5 1.3 9.2 1.3 3.0 2 1 1 3 3 3 0 Golgi transport complex subunit 5 RGS PF00615.19 EFC46487.1 - 0.00021 21.5 0.3 0.00021 21.5 0.3 2.6 2 2 1 3 3 3 1 Regulator of G protein signaling domain F-box-like PF12937.7 EFC46488.1 - 0.00038 20.3 0.5 0.0007 19.4 0.5 1.4 1 0 0 1 1 1 1 F-box-like BRCT PF00533.26 EFC46489.1 - 3.3e-14 53.0 0.0 1.2e-13 51.2 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFC46489.1 - 4.5e-09 36.1 0.0 8.7e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 EFC46489.1 - 3.6e-05 24.1 0.0 0.00011 22.6 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 EFC46489.1 - 0.0056 16.9 0.0 0.027 14.8 0.0 2.2 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain Peptidase_C39_2 PF13529.6 EFC46490.1 - 2.4e-09 37.9 0.0 3e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C39 PF03412.15 EFC46490.1 - 0.00045 20.0 0.1 0.00097 18.9 0.1 1.5 1 1 0 1 1 1 1 Peptidase C39 family Peptidase_C70 PF12385.8 EFC46490.1 - 0.0079 16.2 0.0 0.0094 15.9 0.0 1.3 1 0 0 1 1 1 1 Papain-like cysteine protease AvrRpt2 Synaptobrevin PF00957.21 EFC46493.1 - 1.4e-08 34.4 5.5 3.5e-08 33.1 5.5 1.6 1 0 0 1 1 1 1 Synaptobrevin ANAPC4_WD40 PF12894.7 EFC46493.1 - 0.0016 18.7 0.3 50 4.3 0.1 5.5 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Lipase_chap PF03280.14 EFC46493.1 - 0.049 13.6 0.6 0.082 12.9 0.6 1.2 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein Ras PF00071.22 EFC46494.1 - 1.3e-48 164.6 0.0 1.6e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46494.1 - 2e-29 102.2 0.0 5.9e-29 100.7 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46494.1 - 5.8e-09 35.6 0.0 8.1e-09 35.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFC46494.1 - 0.00081 18.6 0.2 0.13 11.4 0.1 2.5 2 1 1 3 3 3 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC46494.1 - 0.0013 18.1 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 EFC46494.1 - 0.018 14.5 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EFC46494.1 - 0.019 15.0 0.0 0.045 13.8 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFC46494.1 - 0.032 14.6 0.1 0.36 11.2 0.1 2.3 1 1 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 EFC46494.1 - 0.047 14.1 0.0 0.07 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 EFC46494.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFC46494.1 - 0.061 13.3 0.0 0.15 12.0 0.1 1.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 EFC46494.1 - 0.079 12.4 0.3 0.17 11.3 0.0 1.6 2 0 0 2 2 2 0 Poxvirus A32 protein Septin PF00735.18 EFC46494.1 - 0.11 11.7 0.1 0.19 11.0 0.1 1.3 1 0 0 1 1 1 0 Septin AAA_33 PF13671.6 EFC46494.1 - 0.12 12.6 0.1 0.19 11.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFC46494.1 - 0.12 12.3 0.4 0.17 11.7 0.4 1.3 1 0 0 1 1 1 0 NTPase DUF815 PF05673.13 EFC46494.1 - 0.14 11.3 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 EFC46494.1 - 0.15 11.8 0.1 9.3 6.0 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 EFC46494.1 - 0.21 11.5 0.1 18 5.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase adh_short PF00106.25 EFC46495.1 - 2.1e-32 112.2 0.7 2.7e-32 111.8 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC46495.1 - 6.2e-25 88.1 0.1 7.8e-25 87.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC46495.1 - 7.8e-09 35.7 0.2 9.4e-09 35.4 0.2 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 EFC46495.1 - 0.025 14.5 0.3 0.046 13.6 0.3 1.5 1 1 0 1 1 1 0 NAD(P)H-binding 3Beta_HSD PF01073.19 EFC46495.1 - 0.028 13.4 0.2 0.04 12.9 0.2 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFC46495.1 - 0.031 13.4 0.5 0.063 12.4 0.2 1.6 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein Actin PF00022.19 EFC46496.1 - 3.8e-98 328.8 0.0 1.6e-97 326.7 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC46496.1 - 0.093 11.5 0.0 6.8 5.4 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein ELO PF01151.18 EFC46498.1 - 2.1e-51 174.9 23.7 2.6e-51 174.5 23.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family NARP1 PF12569.8 EFC46499.1 - 2.9e-99 333.3 25.3 2.9e-99 333.3 25.3 2.3 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 EFC46499.1 - 1.9e-16 58.8 19.8 0.0074 16.3 0.1 9.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46499.1 - 1.8e-15 57.2 16.5 0.002 18.6 0.3 6.2 4 1 2 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 EFC46499.1 - 4.5e-11 42.6 1.1 0.081 13.8 0.0 6.9 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46499.1 - 1.6e-08 34.1 12.3 0.39 11.0 0.3 7.1 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46499.1 - 1.7e-08 34.2 11.1 0.44 11.0 0.0 7.6 9 0 0 9 9 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC46499.1 - 5.9e-05 23.2 5.4 5.9e-05 23.2 5.4 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFC46499.1 - 0.00021 21.9 3.5 1.7 9.3 0.0 5.7 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC46499.1 - 0.00068 19.7 0.0 4.3 7.6 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46499.1 - 0.0011 18.6 20.2 0.15 11.9 0.0 6.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46499.1 - 0.003 17.8 14.3 0.15 12.4 0.1 6.4 3 2 3 7 7 7 1 Tetratricopeptide repeat Guanylate_cyc_2 PF09778.9 EFC46499.1 - 0.012 15.0 0.3 0.089 12.1 0.1 2.2 2 0 0 2 2 2 0 Guanylylate cyclase TPR_11 PF13414.6 EFC46499.1 - 0.027 14.1 12.3 2 8.2 0.0 5.9 7 1 0 7 7 7 0 TPR repeat TPR_6 PF13174.6 EFC46499.1 - 0.18 12.5 16.6 3.1 8.6 0.2 6.5 7 0 0 7 7 6 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EFC46499.1 - 0.47 10.9 6.9 0.73 10.3 0.3 3.5 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation TPR_3 PF07720.12 EFC46499.1 - 0.6 10.2 10.6 0.52 10.4 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat ParA PF10609.9 EFC46500.1 - 2.3e-94 315.4 0.2 2.7e-94 315.2 0.2 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFC46500.1 - 2.8e-13 50.0 0.1 4.4e-12 46.2 0.1 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 EFC46500.1 - 1.9e-10 40.5 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 ATPase MipZ AAA_31 PF13614.6 EFC46500.1 - 9.4e-10 38.7 4.2 8.4e-07 29.1 1.3 2.4 1 1 1 2 2 2 2 AAA domain ArsA_ATPase PF02374.15 EFC46500.1 - 3e-09 36.5 4.9 4.9e-08 32.5 0.6 2.7 1 1 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 EFC46500.1 - 1.5e-05 24.9 0.0 3.6e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 EFC46500.1 - 0.00013 21.6 0.5 0.00087 18.8 0.2 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 EFC46500.1 - 0.00026 20.7 0.3 0.04 13.5 0.1 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CLP1_P PF16575.5 EFC46500.1 - 0.001 18.9 0.4 0.0025 17.6 0.4 1.8 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop APS_kinase PF01583.20 EFC46500.1 - 0.0014 18.6 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_25 PF13481.6 EFC46500.1 - 0.0015 18.2 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EFC46500.1 - 0.0028 16.7 0.1 0.004 16.2 0.1 1.1 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 EFC46500.1 - 0.0082 15.7 0.2 0.23 10.9 0.1 2.0 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ NB-ARC PF00931.22 EFC46500.1 - 0.021 14.0 0.2 0.036 13.3 0.2 1.4 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 EFC46500.1 - 0.039 13.9 0.2 0.099 12.5 0.2 1.7 1 0 0 1 1 1 0 RsgA GTPase KTI12 PF08433.10 EFC46500.1 - 0.045 13.2 0.2 0.084 12.3 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 NACHT PF05729.12 EFC46500.1 - 0.053 13.4 0.3 0.19 11.6 0.2 1.8 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 EFC46500.1 - 0.069 13.7 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFC46500.1 - 0.14 11.9 0.1 0.99 9.1 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.22 EFC46500.1 - 0.17 12.3 1.2 0.43 11.0 0.3 2.3 3 1 0 3 3 2 0 RNA helicase Ras PF00071.22 EFC46502.1 - 9.8e-53 178.1 0.0 1.2e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46502.1 - 7.7e-25 87.5 0.0 1.4e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46502.1 - 1.9e-10 40.5 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family CH_2 PF06294.11 EFC46503.1 - 3.2e-32 110.5 0.1 3.2e-32 110.5 0.1 3.3 4 0 0 4 4 4 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFC46503.1 - 3e-14 52.6 0.5 4.7e-13 48.8 0.0 2.7 2 0 0 2 2 2 1 CAMSAP CH domain MOR2-PAG1_C PF14225.6 EFC46503.1 - 0.00042 20.3 5.0 0.0067 16.3 0.0 3.8 4 0 0 4 4 4 1 Cell morphogenesis C-terminal Guanylate_cyc PF00211.20 EFC46504.1 - 2.6e-32 111.9 0.0 5.8e-32 110.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain SRP_TPR_like PF17004.5 EFC46504.1 - 0.049 13.7 5.0 0.28 11.2 0.0 3.1 3 0 0 3 3 3 0 Putative TPR-like repeat Auxin_BP PF02041.16 EFC46505.1 - 0.044 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Auxin binding protein DUF1269 PF06897.12 EFC46505.1 - 0.13 12.5 0.3 0.29 11.5 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) TruD PF01142.18 EFC46506.1 - 6.5e-61 206.4 2.0 8.9e-59 199.4 1.5 2.6 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) RPA43_OB PF17875.1 EFC46506.1 - 1.9 9.1 9.2 1.9 9.2 4.6 2.7 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I ACP PF06857.11 EFC46507.1 - 0.059 13.6 0.4 0.62 10.3 0.0 2.7 4 0 0 4 4 4 0 Malonate decarboxylase delta subunit (MdcD) COX14 PF14880.6 EFC46507.1 - 0.082 12.8 0.2 0.19 11.6 0.2 1.6 1 0 0 1 1 1 0 Cytochrome oxidase c assembly EphA2_TM PF14575.6 EFC46507.1 - 0.1 13.5 0.0 0.28 12.1 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain RCC1 PF00415.18 EFC46508.1 - 1.4e-13 51.3 0.0 0.00015 22.3 0.0 5.0 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RGS PF00615.19 EFC46508.1 - 2.1e-13 50.6 2.3 4.7e-13 49.4 2.3 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain GPS PF01825.21 EFC46508.1 - 2.7e-06 27.8 4.3 6.4e-06 26.6 4.3 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif RCC1_2 PF13540.6 EFC46508.1 - 6.5e-05 22.6 0.8 1.1 9.2 0.6 4.4 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC46508.1 - 0.0098 16.2 6.0 0.0098 16.2 6.0 4.0 5 0 0 5 5 5 2 EGF-like domain DUF3566 PF12089.8 EFC46508.1 - 5.9 7.3 11.4 0.9 9.9 5.0 3.1 3 0 0 3 3 3 0 Transmembrane domain of unknown function (DUF3566) EGF_Tenascin PF18720.1 EFC46508.1 - 6 7.0 27.3 0.99 9.5 3.0 4.1 3 0 0 3 3 3 0 Tenascin EGF domain Kinesin PF00225.23 EFC46509.1 - 2.8e-101 338.8 2.9 2.8e-101 338.8 2.9 2.2 1 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC46509.1 - 8.9e-53 178.2 0.1 8.9e-53 178.2 0.1 2.3 2 1 1 3 3 3 1 Microtubule binding CDO_I PF05995.12 EFC46509.1 - 0.03 13.6 1.6 4 6.7 0.3 2.7 2 0 0 2 2 2 0 Cysteine dioxygenase type I PKcGMP_CC PF16808.5 EFC46509.1 - 0.24 11.3 7.6 0.45 10.4 4.9 3.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Androgen_recep PF02166.16 EFC46509.1 - 1.2 7.9 5.9 1.8 7.3 5.9 1.2 1 0 0 1 1 1 0 Androgen receptor DUF3584 PF12128.8 EFC46509.1 - 1.2 6.5 40.2 1.8 5.9 40.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NTF2 PF02136.20 EFC46510.1 - 1.5e-23 83.7 1.6 1.5e-23 83.7 1.6 2.0 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 EFC46510.1 - 2.9e-07 30.2 0.1 6.7e-07 29.0 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC46510.1 - 0.059 13.5 1.8 0.14 12.3 0.0 2.7 3 0 0 3 3 3 0 RNA recognition motif MORN PF02493.20 EFC46511.1 - 3.8e-49 161.7 44.6 4.1e-05 23.2 0.0 14.5 15 1 0 15 15 15 11 MORN repeat Tudor_2 PF18104.1 EFC46511.1 - 0.0047 16.6 8.0 5.2 6.8 0.1 6.4 6 0 0 6 6 6 2 Jumonji domain-containing protein 2A Tudor domain DUF3236 PF11576.8 EFC46512.1 - 0.091 12.5 0.2 0.2 11.4 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) Ank_2 PF12796.7 EFC46513.1 - 3.3e-41 139.8 0.2 5.8e-18 65.3 0.0 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC46513.1 - 3.2e-24 84.7 0.3 7.3e-14 51.7 0.0 3.6 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC46513.1 - 2.8e-23 81.3 0.1 1.5e-08 34.7 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFC46513.1 - 7e-23 80.7 0.1 2e-13 50.5 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC46513.1 - 8.3e-20 68.8 0.2 1.2e-07 31.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Asp PF00026.23 EFC46514.1 - 9e-100 334.1 0.9 1.1e-99 333.8 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFC46514.1 - 9.5e-12 45.5 8.0 7e-09 36.2 8.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EFC46514.1 - 0.087 12.6 0.0 0.46 10.2 0.0 2.0 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal DDHD PF02862.17 EFC46515.1 - 1.1e-24 87.9 8.2 7.1e-18 65.6 0.3 3.4 2 2 1 3 3 3 2 DDHD domain DUF676 PF05057.14 EFC46515.1 - 1.7e-05 24.4 0.1 0.00015 21.4 0.1 2.1 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EFC46515.1 - 8e-05 22.5 0.1 0.0012 18.7 0.0 2.5 3 0 0 3 3 3 1 Lipase (class 3) PGAP1 PF07819.13 EFC46515.1 - 0.016 15.0 0.0 0.028 14.1 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 EFC46515.1 - 0.021 14.9 0.0 0.04 14.0 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain LIDHydrolase PF10230.9 EFC46515.1 - 0.036 13.6 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase tRNA-synt_2b PF00587.25 EFC46515.1 - 0.065 13.2 0.9 4.8 7.1 0.0 2.7 3 0 0 3 3 3 0 tRNA synthetase class II core domain (G, H, P, S and T) Hydrolase_4 PF12146.8 EFC46515.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 ETF_QO PF05187.13 EFC46516.1 - 3.1e-44 149.3 0.2 5.6e-44 148.5 0.2 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Thi4 PF01946.17 EFC46516.1 - 4.8e-08 32.5 0.0 4e-06 26.3 0.0 2.2 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 EFC46516.1 - 1.1e-07 31.4 0.2 5e-05 22.6 0.5 2.1 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 EFC46516.1 - 1.6e-07 31.3 0.2 3.2e-05 23.7 0.1 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC46516.1 - 5.9e-06 26.4 0.0 1.6e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFC46516.1 - 2.2e-05 23.4 0.0 4.7e-05 22.3 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 EFC46516.1 - 3.6e-05 23.2 0.0 0.00019 20.8 0.0 1.9 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC46516.1 - 5.6e-05 22.6 0.0 8.8e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC46516.1 - 0.00035 21.1 0.1 0.22 12.1 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC46516.1 - 0.00039 20.4 0.0 0.00069 19.6 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 EFC46516.1 - 0.0017 17.6 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 EFC46516.1 - 0.002 17.2 0.1 0.0032 16.6 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Fer4_7 PF12838.7 EFC46516.1 - 0.0045 17.5 0.8 0.011 16.3 0.8 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain FAD_binding_3 PF01494.19 EFC46516.1 - 0.0063 15.8 0.0 0.0086 15.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Trp_halogenase PF04820.14 EFC46516.1 - 0.015 14.2 0.0 1.9 7.2 0.1 2.9 3 0 0 3 3 3 0 Tryptophan halogenase FAD_oxidored PF12831.7 EFC46516.1 - 0.2 11.0 0.0 0.38 10.0 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Proteasome PF00227.26 EFC46517.1 - 1.1e-41 142.5 0.0 1.2e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit EMP70 PF02990.16 EFC46518.1 - 2.5e-150 501.6 27.6 2.5e-150 501.6 27.6 1.5 2 0 0 2 2 2 1 Endomembrane protein 70 TRAP_alpha PF03896.16 EFC46518.1 - 0.064 12.5 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TPR_1 PF00515.28 EFC46519.1 - 0.039 13.8 0.0 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-B_box PF00643.24 EFC46519.1 - 0.088 13.0 0.4 0.16 12.1 0.4 1.4 1 0 0 1 1 1 0 B-box zinc finger TPR_1 PF00515.28 EFC46520.1 - 1.5e-20 72.1 12.4 1.1e-05 25.0 0.2 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46520.1 - 3.9e-20 70.3 16.3 0.00013 21.9 0.1 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46520.1 - 1.1e-15 57.7 0.0 3e-07 30.6 0.0 4.4 2 2 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46520.1 - 2.6e-13 48.9 9.1 0.0014 18.6 0.0 7.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC46520.1 - 5.1e-07 29.4 0.0 0.0019 18.0 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC46520.1 - 5.4e-07 29.2 3.2 0.0044 17.0 0.0 4.9 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC46520.1 - 2e-05 24.9 5.1 0.86 10.4 0.2 6.1 7 1 0 7 7 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46520.1 - 4.2e-05 23.6 2.0 0.73 10.4 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat DUF2225 PF09986.9 EFC46520.1 - 0.00049 19.9 1.5 0.00049 19.9 1.5 2.3 1 1 1 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 EFC46520.1 - 0.00056 19.5 5.4 2.1 8.1 0.1 4.5 4 0 0 4 4 4 1 TPR repeat TPR_14 PF13428.6 EFC46520.1 - 0.0044 17.7 0.0 42 5.3 0.0 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46520.1 - 0.046 14.2 0.0 1.2 9.7 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat 6PF2K PF01591.18 EFC46521.1 - 8.2e-71 237.9 1.6 7.8e-44 149.6 1.1 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 EFC46521.1 - 1.2e-29 103.5 0.0 2.5e-29 102.4 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 EFC46521.1 - 2.3e-05 24.6 0.0 8.2e-05 22.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 EFC46521.1 - 0.0018 17.8 0.0 0.0039 16.7 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 EFC46521.1 - 0.057 12.7 0.0 0.93 8.7 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin 5-nucleotidase PF06189.12 EFC46521.1 - 0.074 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 5'-nucleotidase HisKA_2 PF07568.12 EFC46521.1 - 0.096 12.8 0.1 0.28 11.3 0.1 1.7 2 0 0 2 2 2 0 Histidine kinase ATP_bind_1 PF03029.17 EFC46522.1 - 7.3e-85 284.6 0.3 8.3e-85 284.4 0.3 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 EFC46522.1 - 8.6e-05 23.1 0.6 0.0004 20.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 EFC46522.1 - 0.0025 17.3 0.1 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFC46522.1 - 0.0026 18.0 0.0 0.0096 16.2 0.0 2.0 2 1 0 2 2 2 1 AAA domain CLP1_P PF16575.5 EFC46522.1 - 0.0027 17.5 0.0 0.036 13.9 0.0 2.6 3 1 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 EFC46522.1 - 0.004 16.9 0.0 0.0062 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC46522.1 - 0.019 15.4 0.0 0.1 13.0 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 EFC46522.1 - 0.032 14.3 0.3 0.11 12.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 EFC46522.1 - 0.038 13.9 0.2 0.68 9.8 0.0 2.5 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 EFC46522.1 - 0.043 13.5 0.1 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 EFC46522.1 - 0.046 14.1 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFC46522.1 - 0.061 13.8 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 EFC46522.1 - 0.066 13.1 0.0 0.62 10.0 0.0 2.2 1 1 1 2 2 2 0 NTPase AAA_29 PF13555.6 EFC46522.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 EFC46522.1 - 0.072 13.0 0.1 0.35 10.8 0.0 2.0 2 1 0 2 2 2 0 Rad17 P-loop domain AAA_5 PF07728.14 EFC46522.1 - 0.094 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PhoH PF02562.16 EFC46522.1 - 0.1 12.0 0.2 17 4.7 0.0 2.4 2 1 0 2 2 2 0 PhoH-like protein AAA_19 PF13245.6 EFC46522.1 - 0.12 12.8 0.2 0.28 11.5 0.2 1.8 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 EFC46522.1 - 0.12 12.3 0.4 5 7.0 0.1 2.9 2 1 2 4 4 4 0 RsgA GTPase Viral_helicase1 PF01443.18 EFC46522.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 EFC46522.1 - 0.13 11.7 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFC46522.1 - 0.14 12.3 0.0 0.53 10.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 EFC46522.1 - 0.34 10.0 3.8 4 6.5 0.0 2.6 2 1 1 3 3 3 0 G-protein alpha subunit Rit1_C PF17184.4 EFC46523.1 - 3.1e-74 249.9 0.1 4.7e-74 249.3 0.1 1.2 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 EFC46523.1 - 1.6e-16 60.5 0.1 4.9e-16 59.0 0.1 1.8 1 0 0 1 1 1 1 Rit1 DUSP-like domain Synaptobrevin PF00957.21 EFC46524.1 - 2.4e-26 91.3 8.0 3.8e-26 90.7 8.0 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFC46524.1 - 3.8e-18 65.3 0.3 6.4e-18 64.6 0.3 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain ABC2_membrane_3 PF12698.7 EFC46524.1 - 0.0049 16.0 3.3 0.0058 15.8 3.3 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein EVI2A PF05399.11 EFC46524.1 - 0.0079 15.8 2.0 0.011 15.4 2.0 1.2 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) Orf78 PF06024.12 EFC46524.1 - 0.011 16.0 1.2 0.011 16.0 1.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Shisa PF13908.6 EFC46524.1 - 0.047 13.9 1.4 0.078 13.2 1.4 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TPR_19 PF14559.6 EFC46525.1 - 5.5e-10 39.6 0.1 0.33 11.5 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC46525.1 - 3.8e-09 36.6 8.1 0.76 10.8 0.1 7.8 4 3 4 8 8 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46525.1 - 0.092 13.2 1.2 57 4.4 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3793 PF12672.7 EFC46525.1 - 0.11 12.5 0.9 1.4 8.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3793) Suf PF05843.14 EFC46525.1 - 0.78 9.7 12.1 0.82 9.6 0.0 4.7 5 1 1 6 6 6 0 Suppressor of forked protein (Suf) TPR_2 PF07719.17 EFC46525.1 - 1.1 9.6 17.8 46 4.5 0.0 7.7 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46525.1 - 6 7.2 9.2 18 5.7 0.3 4.7 4 1 2 6 6 6 0 Tetratricopeptide repeat OATP PF03137.20 EFC46528.1 - 0.0051 15.2 6.2 0.0063 14.9 6.2 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family KA1 PF02149.19 EFC46528.1 - 0.078 12.8 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Kinase associated domain 1 Vicilin_N PF04702.12 EFC46528.1 - 0.082 12.7 0.6 0.082 12.7 0.6 2.1 2 0 0 2 2 2 0 Vicilin N terminal region Transposase_24 PF03004.14 EFC46528.1 - 0.12 12.4 0.1 0.2 11.8 0.1 1.4 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) PTR2 PF00854.21 EFC46529.1 - 1.1e-97 327.3 15.5 1.5e-97 326.9 15.5 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 EFC46529.1 - 1.6e-17 63.5 22.3 2.4e-17 62.9 22.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Pkinase PF00069.25 EFC46530.1 - 1.1e-48 165.9 0.5 2.4e-48 164.8 0.5 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46530.1 - 5.3e-35 120.9 0.2 2.6e-34 118.7 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC46530.1 - 0.034 12.9 0.1 0.08 11.7 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 EFC46530.1 - 0.041 13.2 0.1 0.074 12.4 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC46530.1 - 0.044 13.7 0.1 0.076 12.9 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family UBA PF00627.31 EFC46531.1 - 6.1e-12 45.2 0.8 1.5e-11 44.0 0.6 1.9 2 0 0 2 2 2 1 UBA/TS-N domain DUF812 PF05667.11 EFC46532.1 - 0.033 13.1 25.3 0.038 12.9 25.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) UPF0242 PF06785.11 EFC46532.1 - 0.35 10.9 35.1 0.018 15.1 21.7 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 EFC46532.1 - 0.65 8.8 33.2 1 8.1 33.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 EFC46532.1 - 0.99 8.9 19.0 1.3 8.5 19.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF883 PF05957.13 EFC46532.1 - 1.2 9.8 14.8 0.32 11.6 7.7 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) FapA PF03961.13 EFC46532.1 - 1.7 7.2 32.3 0.11 11.1 11.0 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A CENP-F_leu_zip PF10473.9 EFC46532.1 - 2.3 8.3 40.5 1.3 9.1 16.8 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 EFC46532.1 - 5 7.7 44.3 0.3 11.6 16.5 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 EFC46532.1 - 6.9 7.6 31.9 2.8 8.9 20.9 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF3584 PF12128.8 EFC46532.1 - 7.3 4.0 33.2 16 2.9 33.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ERM PF00769.19 EFC46532.1 - 7.9 6.2 38.6 15 5.3 38.6 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 EFC46532.1 - 8.3 5.7 25.6 37 3.5 25.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PI3K_P85_iSH2 PF16454.5 EFC46532.1 - 9.2 5.8 31.9 0.24 11.0 12.9 3.1 1 1 1 2 2 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Phage_GP20 PF06810.11 EFC46532.1 - 9.5 6.0 36.6 0.1 12.4 13.7 2.7 1 1 1 2 2 1 0 Phage minor structural protein GP20 Ank_3 PF13606.6 EFC46533.1 - 1.9e-07 30.8 0.4 1.8 9.4 0.0 5.8 5 0 0 5 5 5 2 Ankyrin repeat Ank_2 PF12796.7 EFC46533.1 - 7.4e-06 26.5 0.0 0.045 14.3 0.0 3.8 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC46533.1 - 0.0026 18.0 0.0 54 4.3 0.0 4.9 4 1 1 5 5 5 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC46533.1 - 0.011 16.3 0.2 82 3.9 0.0 5.0 4 1 1 5 5 5 0 Ankyrin repeats (many copies) Tn7_Tnp_TnsA_C PF08721.11 EFC46534.1 - 0.071 13.8 0.6 0.23 12.1 0.3 2.0 2 0 0 2 2 2 0 TnsA endonuclease C terminal DUF551 PF04448.12 EFC46534.1 - 0.09 13.7 0.0 0.63 11.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF551) 4HBT PF03061.22 EFC46535.1 - 3.7e-11 43.2 0.0 4.9e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 EFC46535.1 - 0.06 13.6 0.1 0.17 12.1 0.1 1.7 1 1 0 1 1 1 0 Thioesterase-like superfamily DUF4442 PF14539.6 EFC46535.1 - 0.11 12.6 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) PAP2_C PF14360.6 EFC46537.1 - 7e-18 64.9 9.4 7e-18 64.9 9.4 3.3 3 0 0 3 3 3 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EFC46537.1 - 2.5e-06 27.3 4.3 2.5e-06 27.3 4.3 2.6 2 1 1 3 3 3 1 PAP2 superfamily Ac110_PIF PF07280.11 EFC46537.1 - 0.11 12.3 0.2 0.11 12.3 0.2 2.3 2 0 0 2 2 2 0 Per os infectivity factor AC110 DUF3290 PF11694.8 EFC46537.1 - 4.3 7.3 6.4 0.62 10.0 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) Trypsin PF00089.26 EFC46538.1 - 8.7e-41 140.1 0.0 1.5e-39 136.1 0.0 2.0 1 1 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC46538.1 - 0.0035 18.3 0.1 0.009 16.9 0.1 1.7 1 1 0 1 1 1 1 Trypsin-like peptidase domain DUF1986 PF09342.11 EFC46538.1 - 0.0044 17.4 0.5 0.034 14.5 0.5 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF1986) SWI-SNF_Ssr4 PF08549.10 EFC46539.1 - 3.6 6.1 35.5 5.5 5.5 35.5 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Macoilin PF09726.9 EFC46539.1 - 4.4 5.7 43.9 0.61 8.6 40.1 1.6 2 0 0 2 2 2 0 Macoilin family Totivirus_coat PF05518.11 EFC46539.1 - 5.7 4.9 17.7 7.9 4.4 17.7 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ank_4 PF13637.6 EFC46540.1 - 1.1e-12 48.2 0.2 0.00033 21.2 0.0 3.9 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC46540.1 - 1.3e-12 48.1 0.9 1.9e-06 28.3 0.1 3.7 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFC46540.1 - 3.2e-11 43.2 0.0 2.7e-05 24.4 0.0 4.6 4 1 1 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 EFC46540.1 - 2.7e-10 39.6 1.6 0.0012 19.2 0.0 5.7 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 EFC46540.1 - 1.9e-09 37.6 0.7 0.0031 17.8 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeats (many copies) PI31_Prot_C PF08577.11 EFC46541.1 - 7.6e-13 49.4 6.0 7.6e-13 49.4 6.0 1.6 2 0 0 2 2 2 1 PI31 proteasome regulator T4_Rnl2_C PF18043.1 EFC46542.1 - 1.3e-26 92.5 2.8 1.3e-26 92.5 2.8 2.3 2 0 0 2 2 2 1 T4 RNA ligase 2 C-terminal RNA_ligase PF09414.10 EFC46542.1 - 3.1e-21 76.3 0.9 4.9e-21 75.7 0.9 1.3 1 0 0 1 1 1 1 RNA ligase DUF2564 PF10819.8 EFC46542.1 - 0.15 12.5 1.0 12 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) Tubulin PF00091.25 EFC46543.1 - 4e-51 174.0 0.1 6.2e-51 173.4 0.1 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC46543.1 - 7.4e-09 35.8 0.0 1.9e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 EFC46543.1 - 0.028 13.6 0.1 0.33 10.1 0.2 2.2 2 0 0 2 2 2 0 Tubulin like Tubulin_3 PF14881.6 EFC46543.1 - 0.11 12.2 0.0 0.43 10.2 0.0 1.8 2 0 0 2 2 2 0 Tubulin domain Glutaredoxin PF00462.24 EFC46544.1 - 1.8e-20 72.9 0.0 2.3e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_3 PF13192.6 EFC46544.1 - 3.5e-05 23.7 0.0 4.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain DUF836 PF05768.14 EFC46544.1 - 0.0002 21.7 0.0 0.00026 21.3 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) GST_N_2 PF13409.6 EFC46544.1 - 0.001 19.3 0.0 0.0013 19.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 EFC46544.1 - 0.0036 17.6 0.0 0.0046 17.3 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC46544.1 - 0.0049 17.2 0.0 0.006 17.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Thioredoxin_4 PF13462.6 EFC46544.1 - 0.0091 16.2 1.2 2 8.5 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 EFC46544.1 - 0.055 13.9 0.3 0.081 13.4 0.3 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain BetaGal_dom4_5 PF13364.6 EFC46544.1 - 0.065 13.8 0.0 0.087 13.4 0.0 1.2 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain DSBA PF01323.20 EFC46544.1 - 0.067 13.0 1.2 1.3 8.8 0.3 2.2 1 1 1 2 2 2 0 DSBA-like thioredoxin domain THF_DHG_CYH PF00763.23 EFC46544.1 - 0.12 12.6 0.1 0.17 12.2 0.1 1.3 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Tox-PL-2 PF15643.6 EFC46544.1 - 0.13 12.4 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 Papain fold toxin 2 MIG-14_Wnt-bd PF06664.12 EFC46545.1 - 1.7e-68 231.0 40.4 1.7e-68 231.0 40.4 1.9 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion IFT57 PF10498.9 EFC46545.1 - 0.3 10.0 1.1 0.46 9.4 1.1 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Mito_carr PF00153.27 EFC46546.1 - 2e-53 178.3 2.2 5.1e-21 74.4 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Sel1 PF08238.12 EFC46547.1 - 1.2e-29 102.1 3.4 8.4e-06 26.3 0.1 6.7 7 1 0 7 7 7 5 Sel1 repeat TPR_7 PF13176.6 EFC46547.1 - 0.0049 16.8 3.9 23 5.3 0.0 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46547.1 - 0.0053 16.5 5.4 4.1 7.4 0.1 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46547.1 - 0.021 15.0 7.8 0.73 10.2 0.1 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46547.1 - 0.49 10.6 8.4 22 5.5 0.0 5.1 7 0 0 7 7 7 0 Tetratricopeptide repeat EGF_2 PF07974.13 EFC46548.1 - 2.7e-45 152.4 177.2 1.8e-05 25.0 7.7 12.6 12 0 0 12 12 12 12 EGF-like domain RGS PF00615.19 EFC46548.1 - 1.5e-06 28.4 0.9 1.5e-06 28.4 0.9 2.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain EGF PF00008.27 EFC46548.1 - 0.00029 21.1 138.1 0.056 13.8 3.9 13.2 13 0 0 13 13 13 10 EGF-like domain CitMHS PF03600.16 EFC46549.1 - 0.044 13.0 1.5 0.17 11.0 0.0 1.9 2 0 0 2 2 2 0 Citrate transporter DUF2976 PF11190.8 EFC46549.1 - 0.088 12.6 2.8 5.9 6.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) FAM60A PF15396.6 EFC46549.1 - 0.13 12.3 2.1 0.3 11.1 2.1 1.5 1 0 0 1 1 1 0 Protein Family FAM60A GPDPase_memb PF10110.9 EFC46549.1 - 5.2 5.7 11.9 0.1 11.4 1.0 2.4 3 0 0 3 3 3 0 Membrane domain of glycerophosphoryl diester phosphodiesterase RCC1 PF00415.18 EFC46550.1 - 1.6e-11 44.6 0.0 1.1e-05 25.9 0.0 3.1 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46550.1 - 1.3e-08 34.4 5.8 0.0013 18.4 0.3 5.0 6 0 0 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat Acetyltransf_1 PF00583.25 EFC46551.1 - 4.8e-11 42.9 0.0 9.1e-11 42.0 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC46551.1 - 1.7e-07 31.6 0.0 9.5e-07 29.2 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC46551.1 - 4.4e-05 23.6 0.2 0.01 15.9 0.1 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC46551.1 - 0.00076 19.4 0.0 0.0068 16.4 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 EFC46551.1 - 0.0038 17.4 0.0 0.033 14.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Sugar_tr PF00083.24 EFC46552.1 - 6.4e-43 147.3 29.9 8.5e-43 146.8 29.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFC46552.1 - 6.7e-27 94.3 46.6 9e-21 74.2 28.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 EFC46552.1 - 0.037 12.9 0.2 0.037 12.9 0.2 3.2 2 1 1 3 3 3 0 MFS_1 like family Cas_GSU0053 PF09617.10 EFC46555.1 - 0.064 13.2 0.3 0.076 13.0 0.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) U-box PF04564.15 EFC46556.1 - 1.3e-06 28.5 0.0 6.3e-06 26.3 0.0 2.3 1 0 0 1 1 1 1 U-box domain Myb_DNA-binding PF00249.31 EFC46556.1 - 0.00039 20.5 2.0 0.00048 20.3 0.2 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain PRCC PF10253.9 EFC46556.1 - 9.4 7.0 50.5 0.33 11.7 6.9 3.5 3 0 0 3 3 3 0 Mitotic checkpoint regulator, MAD2B-interacting Arm PF00514.23 EFC46557.1 - 0.095 12.8 0.4 2.8 8.1 0.0 3.2 3 1 1 4 4 4 0 Armadillo/beta-catenin-like repeat Sod_Fe_C PF02777.18 EFC46558.1 - 4.5e-39 132.7 1.1 9.2e-39 131.7 0.1 1.8 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 EFC46558.1 - 1.4e-22 80.0 1.9 1.4e-22 80.0 1.9 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Ank_2 PF12796.7 EFC46559.1 - 1.7e-17 63.7 0.0 8.5e-09 35.9 0.0 3.1 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFC46559.1 - 2.7e-17 62.3 0.1 0.00015 22.0 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFC46559.1 - 1.4e-13 51.0 0.2 5.2e-05 23.7 0.0 4.4 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC46559.1 - 6.7e-12 45.4 0.1 2.4e-07 30.9 0.0 4.8 6 0 0 6 6 6 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC46559.1 - 3.2e-11 42.4 2.4 0.00064 20.0 0.0 6.2 5 2 0 5 5 5 2 Ankyrin repeat TMEM154 PF15102.6 EFC46561.1 - 0.0011 18.8 0.1 0.0037 17.2 0.0 1.7 1 1 1 2 2 2 1 TMEM154 protein family Sam68-YY PF16568.5 EFC46561.1 - 0.029 15.1 0.3 0.064 14.0 0.3 1.5 1 0 0 1 1 1 0 Tyrosine-rich domain of Sam68 Cadherin_C_2 PF16492.5 EFC46561.1 - 0.18 12.5 2.0 0.22 12.3 0.3 1.9 1 1 1 2 2 2 0 Cadherin cytoplasmic C-terminal DLL_N PF12413.8 EFC46561.1 - 0.84 10.9 6.2 0.57 11.4 3.6 2.0 2 0 0 2 2 2 0 Homeobox protein distal-less-like N terminal ResIII PF04851.15 EFC46563.1 - 4e-23 82.3 3.9 5e-23 81.9 0.1 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC46563.1 - 8.6e-20 71.1 1.1 2.5e-18 66.4 0.1 3.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC46563.1 - 1.8e-15 57.1 0.1 2e-14 53.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 EFC46563.1 - 0.0015 18.0 0.0 0.0077 15.7 0.0 2.1 2 0 0 2 2 2 1 PhoH-like protein AAA_25 PF13481.6 EFC46563.1 - 0.0028 17.2 0.0 0.0054 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Terminase_6 PF03237.15 EFC46563.1 - 0.008 15.9 0.1 0.021 14.5 0.0 1.7 2 0 0 2 2 2 1 Terminase-like family IstB_IS21 PF01695.17 EFC46563.1 - 0.0082 15.9 0.1 0.13 12.0 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_19 PF13245.6 EFC46563.1 - 0.023 15.0 0.0 0.063 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFC46563.1 - 0.036 13.8 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 EFC46563.1 - 0.048 13.7 1.1 0.18 11.9 0.0 2.4 2 1 1 3 3 3 0 Helicase HerA, central domain Ribosomal_S6e PF01092.19 EFC46563.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S6e Sigma54_activat PF00158.26 EFC46563.1 - 0.074 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Dicer_dimer PF03368.14 EFC46563.1 - 0.14 12.3 0.0 16 5.8 0.0 3.1 3 0 0 3 3 3 0 Dicer dimerisation domain MPC PF03650.13 EFC46564.1 - 2.6e-38 130.6 0.1 2.8e-38 130.4 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MORN PF02493.20 EFC46566.1 - 1e-24 84.9 29.6 2.1e-08 33.6 0.6 6.1 6 0 0 6 6 6 4 MORN repeat DUF1579 PF07617.11 EFC46566.1 - 0.019 14.9 1.8 0.023 14.6 0.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1579) LRR_4 PF12799.7 EFC46567.1 - 0.058 13.8 3.2 1.5 9.3 0.2 2.8 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DUF2807 PF10988.8 EFC46567.1 - 0.19 11.5 0.0 0.43 10.3 0.0 1.6 1 1 1 2 2 2 0 Putative auto-transporter adhesin, head GIN domain GBP PF02263.19 EFC46568.1 - 1.9e-60 204.3 0.1 2.4e-60 204.0 0.1 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain AAA_14 PF13173.6 EFC46568.1 - 0.04 14.0 0.2 0.78 9.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain EF-hand_1 PF00036.32 EFC46569.1 - 4e-06 26.0 2.5 0.019 14.5 0.3 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC46569.1 - 0.00011 22.6 1.2 0.00011 22.6 1.2 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC46569.1 - 0.00018 21.1 2.1 0.26 11.3 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 EFC46569.1 - 0.21 11.5 2.7 0.48 10.3 0.2 2.7 3 0 0 3 3 3 0 EF-hand domain pair DcrB PF08786.11 EFC46569.1 - 0.49 10.5 4.6 1.8 8.7 0.0 3.4 4 1 0 4 4 4 0 DcrB Proteasome PF00227.26 EFC46570.1 - 2.1e-47 161.1 0.3 3.6e-47 160.3 0.3 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFC46570.1 - 2.2e-14 52.8 0.2 3.6e-14 52.1 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature IRK_C PF17655.1 EFC46571.1 - 7.1e-18 64.8 0.3 7.3e-16 58.3 0.0 2.5 3 0 0 3 3 3 2 Inward rectifier potassium channel C-terminal domain Ion_trans_2 PF07885.16 EFC46571.1 - 0.00046 20.1 3.3 0.00081 19.3 3.3 1.4 1 0 0 1 1 1 1 Ion channel IRK PF01007.20 EFC46571.1 - 0.011 15.6 0.4 0.023 14.5 0.1 1.7 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain Gelsolin PF00626.22 EFC46573.1 - 2.1e-35 120.5 9.7 3.9e-09 36.3 0.0 7.6 7 1 1 8 8 8 5 Gelsolin repeat Metallophos PF00149.28 EFC46573.1 - 0.00013 22.6 0.1 0.0027 18.2 0.0 2.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC46573.1 - 0.0012 19.1 0.0 0.048 13.9 0.0 2.6 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Peptidase_C10 PF01640.17 EFC46573.1 - 0.066 13.5 1.0 1.2 9.4 0.0 2.9 3 0 0 3 3 3 0 Peptidase C10 family C2 PF00168.30 EFC46574.1 - 3e-13 49.9 0.0 1.1e-12 48.1 0.0 2.1 2 0 0 2 2 2 1 C2 domain Peptidase_C97 PF05903.14 EFC46574.1 - 0.00012 21.9 0.0 0.00029 20.7 0.0 1.6 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 EFC46574.1 - 0.072 13.4 0.0 0.25 11.7 0.0 2.0 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Toxin_R_bind_C PF07951.12 EFC46575.1 - 0.085 12.5 0.1 0.085 12.5 0.1 1.2 1 0 0 1 1 1 0 Clostridium neurotoxin, C-terminal receptor binding HydF_tetramer PF18133.1 EFC46577.1 - 2e-40 137.2 0.0 4.6e-40 136.0 0.0 1.7 1 0 0 1 1 1 1 Hydrogen maturase F tetramerization domain MMR_HSR1 PF01926.23 EFC46577.1 - 6e-20 71.4 0.1 1.3e-19 70.3 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC46577.1 - 5.9e-12 45.4 0.2 1.2e-11 44.4 0.2 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC46577.1 - 5.5e-07 29.8 0.4 0.00084 19.4 0.3 2.6 1 1 0 2 2 2 2 Dynamin family HydF_dimer PF18128.1 EFC46577.1 - 4e-06 26.8 2.4 0.00035 20.6 0.2 3.2 2 1 0 2 2 1 1 Hydrogen maturase F dimerization domain GTP_EFTU PF00009.27 EFC46577.1 - 0.00061 19.4 1.8 0.033 13.7 1.8 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC46577.1 - 0.0054 16.7 1.4 0.0094 15.9 0.4 1.9 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 EFC46577.1 - 0.012 15.0 0.1 0.032 13.6 0.1 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC46577.1 - 0.018 15.2 0.0 0.067 13.4 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 EFC46577.1 - 0.035 14.4 0.3 0.32 11.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 EFC46577.1 - 0.044 14.3 0.3 0.13 12.8 0.2 1.7 1 1 0 1 1 1 0 ABC transporter Ras PF00071.22 EFC46577.1 - 0.045 13.4 0.0 0.091 12.4 0.0 1.5 1 1 0 1 1 1 0 Ras family AAA_29 PF13555.6 EFC46577.1 - 0.057 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFC46577.1 - 0.09 12.1 0.1 0.17 11.2 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_14 PF13173.6 EFC46577.1 - 0.093 12.8 0.1 6.7 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 EFC46577.1 - 7 7.1 6.9 56 4.1 6.9 2.5 1 1 0 1 1 1 0 AAA domain Metallophos PF00149.28 EFC46578.1 - 7.4e-12 46.2 6.6 1.5e-11 45.2 6.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC46578.1 - 0.00036 20.8 2.7 0.0023 18.2 2.7 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2207 PF09972.9 EFC46579.1 - 0.014 14.1 5.4 0.045 12.5 5.1 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EFC46579.1 - 0.6 10.2 3.4 1.1 9.3 3.4 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III ETRAMP PF09716.10 EFC46579.1 - 1.5 9.0 3.3 9.5 6.4 0.9 2.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF2207 PF09972.9 EFC46580.1 - 8.2e-06 24.9 0.5 1.1e-05 24.4 0.5 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 EFC46580.1 - 0.22 11.6 4.6 0.4 10.7 4.6 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SseC PF04888.12 EFC46580.1 - 0.74 9.4 5.0 0.37 10.3 2.2 1.9 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF262 PF03235.14 EFC46581.1 - 8.4e-31 107.9 2.2 8.4e-31 107.9 2.2 3.9 2 1 1 3 3 3 1 Protein of unknown function DUF262 DUF4241 PF14025.6 EFC46581.1 - 0.015 15.6 0.1 0.04 14.2 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4241) 7tm_6 PF02949.20 EFC46581.1 - 0.087 11.9 0.1 0.29 10.2 0.0 1.8 2 0 0 2 2 2 0 7tm Odorant receptor DUF4116 PF13475.6 EFC46582.1 - 2.1e-156 507.6 66.7 2.8e-16 59.0 0.2 20.2 12 7 9 22 22 22 21 Domain of unknown function (DUF4116) LIDHydrolase PF10230.9 EFC46582.1 - 0.02 14.5 0.1 0.059 12.9 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Exo_endo_phos PF03372.23 EFC46583.1 - 3.3e-09 36.6 0.2 6e-09 35.8 0.2 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family NUDIX PF00293.28 EFC46584.1 - 4.9e-09 36.3 0.0 6.7e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DUF5082 PF16888.5 EFC46585.1 - 0.07 13.4 3.9 0.071 13.4 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Cofilin_ADF PF00241.20 EFC46586.1 - 1.3e-23 83.1 0.9 1.5e-23 82.9 0.9 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF4432 PF14486.6 EFC46586.1 - 0.049 12.4 0.1 0.056 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) DUF2187 PF09953.9 EFC46586.1 - 0.049 13.6 0.1 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) Myb_DNA-binding PF00249.31 EFC46587.1 - 1e-10 41.7 1.7 1.7e-10 40.9 1.7 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC46587.1 - 0.00019 21.2 1.0 0.00036 20.4 0.3 1.8 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFC46587.1 - 0.025 14.8 0.9 0.07 13.4 0.9 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain tRNA_synt_1c_R2 PF04557.15 EFC46587.1 - 0.096 13.6 2.2 0.25 12.3 2.2 1.6 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 EamA PF00892.20 EFC46588.1 - 5.1e-27 94.7 40.1 2.2e-16 60.3 17.3 2.5 2 1 0 2 2 2 2 EamA-like transporter family DUF456 PF04306.13 EFC46588.1 - 0.0013 19.1 3.6 0.0013 19.1 3.6 3.4 2 1 0 3 3 3 1 Protein of unknown function (DUF456) DUF2371 PF10177.9 EFC46588.1 - 0.027 14.6 4.6 12 6.1 0.0 3.6 3 1 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) Insulin_TMD PF17870.1 EFC46588.1 - 1.1 9.3 0.0 1.1 9.3 0.0 3.7 5 0 0 5 5 5 0 Insulin receptor trans-membrane segment DUF1129 PF06570.11 EFC46588.1 - 2.1 7.8 11.3 1.1 8.7 3.9 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1129) Ank_2 PF12796.7 EFC46590.1 - 5.5e-45 151.9 16.5 5.3e-10 39.7 0.1 9.8 5 3 4 10 10 10 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC46590.1 - 2.6e-39 133.1 9.5 1.9e-08 34.6 0.1 8.4 7 1 1 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC46590.1 - 3.1e-36 122.9 2.7 2e-10 40.7 0.1 9.6 9 1 0 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 EFC46590.1 - 1.8e-28 97.7 16.7 0.00011 22.4 0.0 12.2 12 0 0 12 12 12 6 Ankyrin repeat Ank_3 PF13606.6 EFC46590.1 - 3.2e-26 88.5 13.2 2.6e-05 24.2 0.0 13.4 14 1 0 14 14 14 4 Ankyrin repeat F-box-like PF12937.7 EFC46590.1 - 0.0031 17.4 0.1 0.008 16.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like Fibrillarin PF01269.17 EFC46592.1 - 9.7e-16 57.6 0.0 1.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Fibrillarin Securin PF04856.13 EFC46592.1 - 0.073 13.0 0.0 0.097 12.6 0.0 1.1 1 0 0 1 1 1 0 Securin sister-chromatid separation inhibitor Pkinase PF00069.25 EFC46593.1 - 1.3e-12 47.7 0.1 1.8e-11 44.0 0.0 3.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46593.1 - 2.2e-09 37.0 0.0 1.3e-08 34.4 0.0 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase HEAT PF02985.22 EFC46593.1 - 0.00016 21.6 0.2 47 4.6 0.0 4.9 4 0 0 4 4 4 0 HEAT repeat PKcGMP_CC PF16808.5 EFC46593.1 - 0.00057 19.7 2.5 0.00057 19.7 2.5 6.3 7 1 0 7 7 7 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Spc7 PF08317.11 EFC46593.1 - 0.00068 18.6 16.5 0.00068 18.6 16.5 7.2 2 1 3 7 7 7 2 Spc7 kinetochore protein DUF4116 PF13475.6 EFC46594.1 - 1.5e-49 165.5 23.9 8.8e-14 51.0 0.2 8.9 7 3 2 9 9 9 7 Domain of unknown function (DUF4116) Voltage_CLC PF00654.20 EFC46596.1 - 1.7e-57 195.3 31.0 1.7e-57 195.3 31.0 2.1 1 1 1 2 2 2 1 Voltage gated chloride channel SecD-TM1 PF13721.6 EFC46596.1 - 1.5 9.3 4.3 6.4 7.3 0.0 3.2 4 0 0 4 4 4 0 SecD export protein N-terminal TM region Q_salvage PF10343.9 EFC46597.1 - 1.7e-30 106.6 0.4 2.7e-30 105.9 0.4 1.4 1 1 0 1 1 1 1 Potential Queuosine, Q, salvage protein family HALZ PF02183.18 EFC46598.1 - 0.034 14.4 3.3 0.33 11.2 3.3 2.8 1 1 0 1 1 1 0 Homeobox associated leucine zipper EspB_PE PF18625.1 EFC46598.1 - 0.16 12.5 0.7 1.5 9.4 0.0 2.8 3 0 0 3 3 3 0 ESX-1 secreted protein B PE domain Big_9 PF17963.1 EFC46599.1 - 3.4e-91 300.2 241.4 2.5e-12 47.4 6.2 23.3 21 4 1 22 22 22 18 Bacterial Ig domain Cadherin_4 PF17803.1 EFC46599.1 - 1.9e-56 188.6 159.8 2.5e-11 44.0 6.5 18.6 18 1 0 18 18 18 13 Bacterial cadherin-like domain Cadherin_5 PF17892.1 EFC46599.1 - 1.9e-30 104.7 118.3 1.7e-06 27.9 0.7 19.7 14 4 5 19 19 19 11 Cadherin-like domain VWA PF00092.28 EFC46599.1 - 1.2e-23 84.3 2.0 2.9e-23 83.0 0.6 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC46599.1 - 1.4e-13 51.4 1.0 6.1e-13 49.4 1.0 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain KilA-N PF04383.13 EFC46599.1 - 0.0088 15.9 0.0 0.038 13.9 0.0 2.1 2 0 0 2 2 2 1 KilA-N domain 3Beta_HSD PF01073.19 EFC46600.1 - 1.7e-12 46.9 0.0 2.7e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC46600.1 - 3.3e-11 43.1 0.0 3.9e-10 39.6 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC46600.1 - 9.6e-08 32.1 0.0 1.8e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 EFC46600.1 - 4.4e-07 29.3 0.1 0.0013 18.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 EFC46600.1 - 9.7e-06 25.3 0.0 3e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EFC46600.1 - 1.6e-05 24.4 0.0 2.8e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 EFC46600.1 - 0.0011 18.9 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 KR domain RWP-RK PF02042.15 EFC46601.1 - 1.2e-19 70.0 0.0 2.1e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 RWP-RK domain MSC PF09402.10 EFC46603.1 - 0.3 10.5 14.9 0.27 10.7 9.2 2.7 1 1 1 2 2 2 0 Man1-Src1p-C-terminal domain Glyco_transf_22 PF03901.17 EFC46604.1 - 3.1e-83 280.3 29.3 3.7e-83 280.1 29.3 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF932 PF06067.11 EFC46605.1 - 0.8 9.4 4.6 0.28 10.9 0.3 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF932) Prp19 PF08606.11 EFC46605.1 - 1.3 9.0 5.6 1.7 8.7 1.6 2.6 2 0 0 2 2 2 0 Prp19/Pso4-like DUF745 PF05335.13 EFC46605.1 - 2.1 8.0 6.6 6.4 6.4 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Phage_Mu_Gam PF07352.12 EFC46605.1 - 5.4 6.9 20.1 0.18 11.7 1.7 3.1 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein LRR_4 PF12799.7 EFC46606.1 - 3.1e-27 94.2 51.8 0.00022 21.6 3.2 11.1 3 3 11 14 14 14 14 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46606.1 - 3.2e-27 94.1 43.2 6e-08 32.3 1.7 7.9 6 2 3 9 9 9 8 Leucine rich repeat LRR_6 PF13516.6 EFC46606.1 - 5.2e-19 66.6 48.9 0.039 14.0 0.0 15.6 17 0 0 17 17 17 7 Leucine Rich repeat LRR_9 PF14580.6 EFC46606.1 - 8.7e-09 35.1 13.4 0.003 17.1 0.3 4.6 1 1 4 6 6 6 5 Leucine-rich repeat LRR_1 PF00560.33 EFC46606.1 - 2e-07 30.6 44.2 1.9 9.3 0.3 14.4 14 3 0 14 14 14 3 Leucine Rich Repeat F-box-like PF12937.7 EFC46606.1 - 0.0053 16.6 0.1 0.013 15.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.13 EFC46606.1 - 3.3 8.5 0.0 3.3 8.5 0.0 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat HA2 PF04408.23 EFC46607.1 - 8.6e-25 87.1 0.0 1.6e-24 86.3 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFC46607.1 - 5.5e-22 77.9 0.0 1e-21 77.1 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFC46607.1 - 4.7e-10 39.8 0.0 9.1e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Pkinase PF00069.25 EFC46609.1 - 3.4e-77 259.4 0.1 3.8e-77 259.2 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46609.1 - 1.7e-32 112.8 0.1 1.4e-31 109.7 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 EFC46609.1 - 2e-05 24.0 2.1 7.5e-05 22.2 2.1 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFC46609.1 - 4.5e-05 23.1 0.5 6.7e-05 22.6 0.5 1.2 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 EFC46609.1 - 5.6e-05 23.2 0.0 7.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC46609.1 - 0.00021 20.3 1.6 0.00033 19.7 1.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFC46609.1 - 0.00031 20.1 1.2 0.089 12.1 0.4 2.2 1 1 1 2 2 2 2 Kinase-like YrbL-PhoP_reg PF10707.9 EFC46609.1 - 0.0048 16.4 0.5 0.0081 15.7 0.1 1.5 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EFC46609.1 - 0.0059 15.4 0.2 0.0099 14.7 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 EFC46609.1 - 0.014 15.0 0.6 0.59 9.7 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 EFC46609.1 - 0.051 13.1 1.3 0.099 12.2 1.3 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase PIP49_C PF12260.8 EFC46609.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 PseudoU_synth_2 PF00849.22 EFC46610.1 - 2.5e-17 63.4 1.4 9.1e-17 61.6 1.4 1.9 1 1 0 1 1 1 1 RNA pseudouridylate synthase DUF4382 PF14321.6 EFC46610.1 - 0.0055 17.0 0.0 0.024 14.9 0.0 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4382) CAC1F_C PF16885.5 EFC46610.1 - 0.093 12.4 0.5 3 7.4 0.5 2.2 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Eaf7 PF07904.13 EFC46610.1 - 0.22 11.9 5.5 0.23 11.9 2.4 2.7 2 1 0 2 2 2 0 Chromatin modification-related protein EAF7 Spt5_N PF11942.8 EFC46610.1 - 5.2 8.1 9.6 3.3 8.8 7.2 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Amidohydro_1 PF01979.20 EFC46611.1 - 2.6e-21 76.3 0.0 6.9e-21 74.9 0.0 1.7 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFC46611.1 - 3.6e-08 33.3 0.0 5.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase family DSPc PF00782.20 EFC46612.1 - 5.2e-35 120.2 0.5 6e-35 120.0 0.5 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 EFC46612.1 - 6e-06 25.9 0.1 7.6e-06 25.6 0.1 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC46612.1 - 0.00017 21.2 0.0 0.00022 20.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFC46612.1 - 0.00077 19.7 0.0 0.001 19.3 0.0 1.2 1 0 0 1 1 1 1 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFC46612.1 - 0.0018 18.4 0.0 0.0026 17.9 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Nrap_D6 PF17407.2 EFC46612.1 - 0.037 14.3 0.0 0.043 14.0 0.0 1.2 1 0 0 1 1 1 0 Nrap protein domain 6 Raptor_N PF14538.6 EFC46612.1 - 0.057 13.4 0.0 0.084 12.8 0.0 1.3 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain 2OG-FeII_Oxy_2 PF13532.6 EFC46613.1 - 1.1e-17 64.9 0.1 3.3e-16 60.1 0.1 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC46613.1 - 0.0081 16.6 0.1 0.016 15.7 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Transcrip_reg PF01709.20 EFC46614.1 - 1.3e-56 191.7 0.3 1.5e-56 191.5 0.3 1.1 1 0 0 1 1 1 1 Transcriptional regulator DUF1963 PF09234.10 EFC46614.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1963) Elf1 PF05129.13 EFC46615.1 - 2.5e-29 101.2 1.9 3.6e-29 100.6 1.9 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-LITAF-like PF10601.9 EFC46615.1 - 0.028 14.7 5.1 1.5 9.2 0.6 2.2 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain OrfB_Zn_ribbon PF07282.11 EFC46615.1 - 0.031 14.2 1.3 0.067 13.1 1.3 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.7 EFC46615.1 - 0.057 13.4 2.1 0.11 12.5 2.1 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain EST1_DNA_bind PF10373.9 EFC46615.1 - 0.11 12.0 0.1 0.12 11.8 0.1 1.1 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain Rubredoxin PF00301.20 EFC46615.1 - 0.13 12.3 3.3 5.2 7.2 0.6 2.7 2 0 0 2 2 2 0 Rubredoxin Lar_restr_allev PF14354.6 EFC46615.1 - 0.14 12.6 9.0 1 9.8 9.0 2.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar SIR2 PF02146.17 EFC46615.1 - 0.24 11.3 2.2 0.24 11.3 1.2 1.4 1 1 0 1 1 1 0 Sir2 family PriA_CRR PF18319.1 EFC46615.1 - 2.6 8.1 4.8 1.5 8.9 0.3 2.3 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain zf-Di19 PF05605.12 EFC46615.1 - 5.4 7.4 7.2 3 8.2 3.7 2.3 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding GMC_oxred_N PF00732.19 EFC46616.1 - 4.8e-62 210.0 0.1 5.9e-61 206.4 0.1 2.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 EFC46616.1 - 3.4e-37 128.2 0.0 6.4e-37 127.3 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Thi4 PF01946.17 EFC46616.1 - 0.00023 20.5 0.0 0.00045 19.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 EFC46616.1 - 0.0017 18.6 0.0 0.0043 17.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 EFC46616.1 - 0.017 14.2 0.1 0.035 13.1 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 EFC46616.1 - 0.03 13.4 0.0 0.2 10.7 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Pyr_redox_2 PF07992.14 EFC46616.1 - 0.081 12.1 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IF2_N PF04760.15 EFC46616.1 - 0.085 12.7 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Ski_Sno PF02437.17 EFC46616.1 - 0.18 11.5 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 SKI/SNO/DAC family GCS PF03074.16 EFC46617.1 - 8.6e-155 515.6 5.9 1.5e-154 514.8 5.9 1.4 1 0 0 1 1 1 1 Glutamate-cysteine ligase Pullulanase_Ins PF18494.1 EFC46617.1 - 0.0043 17.5 0.2 0.015 15.8 0.2 2.0 1 0 0 1 1 1 1 Pullulanase Ins domain Plavaka PF18759.1 EFC46618.1 - 0.068 12.4 2.2 0.67 9.1 2.2 2.2 1 1 0 1 1 1 0 Plavaka transposase Fimbrial_PilY2 PF14481.6 EFC46618.1 - 0.15 11.8 0.0 0.51 10.0 0.0 1.8 2 0 0 2 2 2 0 Type 4 fimbrial biogenesis protein PilY2 EMC3_TMCO1 PF01956.16 EFC46620.1 - 3.5 7.3 6.9 0.32 10.7 1.9 1.6 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DSPc PF00782.20 EFC46621.1 - 2.7e-30 104.9 0.6 3.1e-30 104.7 0.6 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 EFC46621.1 - 0.00015 21.4 0.4 0.0002 21.0 0.4 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC46621.1 - 0.0012 18.5 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFC46621.1 - 0.0086 16.4 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain CDKN3 PF05706.12 EFC46621.1 - 0.016 14.9 0.1 0.024 14.3 0.1 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EFC46621.1 - 0.054 13.6 0.0 0.059 13.5 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate CDO_I PF05995.12 EFC46621.1 - 0.15 11.3 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Cysteine dioxygenase type I DSPc PF00782.20 EFC46622.1 - 2.6e-30 104.9 0.7 2.6e-30 104.9 0.7 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase2 PF03162.13 EFC46622.1 - 0.00031 20.4 0.3 0.00059 19.4 0.3 1.5 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC46622.1 - 0.0018 17.9 0.2 0.0027 17.3 0.2 1.5 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 EFC46622.1 - 0.0043 16.1 0.1 1.1 8.1 0.0 2.2 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain Init_tRNA_PT PF04179.12 EFC46622.1 - 0.012 15.9 0.1 0.031 14.6 0.0 1.7 2 0 0 2 2 2 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 EFC46622.1 - 0.018 15.2 0.2 0.057 13.5 0.2 1.9 1 1 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 EFC46622.1 - 0.029 14.0 0.0 0.045 13.4 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Methyltransf_16 PF10294.9 EFC46622.1 - 0.13 12.0 1.7 11 5.7 0.1 2.2 2 0 0 2 2 2 0 Lysine methyltransferase Pro_isomerase PF00160.21 EFC46623.1 - 1.9e-50 171.2 0.3 2.1e-50 171.1 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 EFC46623.1 - 0.0073 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Kri1 PF05178.12 EFC46624.1 - 0.049 14.2 2.4 0.13 12.8 2.4 1.7 1 0 0 1 1 1 0 KRI1-like family FTO_NTD PF12933.7 EFC46624.1 - 3.1 7.0 7.0 0.46 9.7 2.6 1.8 2 0 0 2 2 2 0 FTO catalytic domain DUF3527 PF12043.8 EFC46624.1 - 7.2 6.1 8.7 0.55 9.7 2.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3527) TPR_12 PF13424.6 EFC46625.1 - 1.9e-09 37.6 1.6 0.0036 17.6 0.1 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46625.1 - 3.5e-06 26.7 2.6 0.61 10.3 0.2 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46625.1 - 2.1e-05 24.4 9.1 0.97 9.8 0.3 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC46625.1 - 4.3e-05 23.7 9.2 0.0038 17.4 0.2 4.2 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC46625.1 - 5.1e-05 23.7 8.0 0.21 12.1 0.2 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC46625.1 - 9.4e-05 22.8 1.7 4.7 8.1 0.2 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC46625.1 - 0.00085 19.9 0.0 7.6 7.6 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46625.1 - 0.0014 18.4 11.6 0.33 10.9 0.5 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_21 PF09976.9 EFC46625.1 - 0.0022 17.7 11.1 0.71 9.6 0.7 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat-like domain TPR_7 PF13176.6 EFC46625.1 - 0.0083 16.1 0.1 13 6.1 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EFC46625.1 - 0.012 15.8 4.2 0.97 9.8 0.1 4.1 5 0 0 5 5 5 0 PPR repeat Whi5 PF08528.11 EFC46625.1 - 0.04 13.6 0.1 0.085 12.5 0.1 1.6 1 0 0 1 1 1 0 Whi5 like TPR_11 PF13414.6 EFC46625.1 - 0.044 13.5 1.4 9.4 6.0 0.0 3.1 3 0 0 3 3 3 0 TPR repeat ANAPC5 PF12862.7 EFC46625.1 - 0.16 12.1 7.9 1.1 9.4 0.8 2.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 5 DUF2225 PF09986.9 EFC46625.1 - 0.63 9.7 7.6 0.1 12.3 1.8 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Cob_adeno_trans PF01923.18 EFC46625.1 - 0.67 10.1 4.2 1.3 9.2 1.1 2.9 1 1 1 3 3 3 0 Cobalamin adenosyltransferase DUF1640 PF07798.11 EFC46626.1 - 0.065 13.3 13.2 0.11 12.5 11.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Cas6b_C PF17262.2 EFC46626.1 - 0.15 12.1 4.2 0.35 11.0 4.2 1.7 1 0 0 1 1 1 0 Cas6b C-terminal domain Cpn60_TCP1 PF00118.24 EFC46628.1 - 2.7e-31 108.8 0.3 1.7e-16 59.9 0.2 2.1 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family p450 PF00067.22 EFC46629.1 - 1.1e-09 37.6 1.5 2.3e-09 36.5 0.7 2.0 2 1 0 2 2 2 1 Cytochrome P450 Myb_DNA-binding PF00249.31 EFC46629.1 - 9.5e-06 25.7 0.0 2.4e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Sugar_tr PF00083.24 EFC46630.1 - 4.3e-67 226.9 34.0 7.5e-66 222.8 34.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFC46630.1 - 1.4e-26 93.2 28.1 4.7e-21 75.1 8.6 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily TssN PF17555.2 EFC46630.1 - 0.01 15.2 1.6 0.01 15.2 1.6 2.8 3 0 0 3 3 3 0 Type VI secretion system, TssN Lipase_3 PF01764.25 EFC46631.1 - 2.8e-11 43.4 0.0 6.8e-10 39.0 0.0 2.8 1 1 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 EFC46631.1 - 0.039 13.5 0.3 2.1 7.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) LRR_4 PF12799.7 EFC46632.1 - 1.1e-15 57.4 16.9 4.4e-06 26.9 5.4 4.5 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46632.1 - 1.1e-13 50.7 7.1 1.7e-07 30.9 4.4 3.4 3 1 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 EFC46632.1 - 5.5e-05 22.7 2.2 9.8e-05 21.9 2.2 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 EFC46632.1 - 6.7e-05 22.6 14.7 0.65 10.2 0.6 5.5 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 EFC46632.1 - 0.036 14.6 14.0 9.8 7.2 0.1 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat Cellulase PF00150.18 EFC46633.1 - 1e-34 120.2 1.0 2.5e-34 119.0 1.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 EFC46633.1 - 6.9e-10 39.3 0.0 1.4e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_35 PF01301.19 EFC46633.1 - 8.8e-06 25.6 0.0 1.5e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Glyco_hydro_42 PF02449.15 EFC46633.1 - 6.3e-05 22.5 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase DUF871 PF05913.11 EFC46633.1 - 0.056 12.6 0.2 0.14 11.4 0.2 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF871) Ras PF00071.22 EFC46634.1 - 6.4e-42 142.9 0.0 4.2e-37 127.2 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC46634.1 - 1.4e-32 112.4 0.0 2.8e-32 111.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46634.1 - 5.8e-14 51.9 0.0 8.6e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC46634.1 - 2.2e-06 27.2 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC46634.1 - 0.00048 20.2 0.7 0.00068 19.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC46634.1 - 0.0012 18.3 0.0 0.0022 17.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 EFC46634.1 - 0.0025 17.8 0.3 0.74 9.7 0.0 2.9 3 1 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 EFC46634.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Methyltransf_29 PF03141.16 EFC46634.1 - 0.024 13.2 0.0 0.034 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase AAA_7 PF12775.7 EFC46634.1 - 0.071 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DAP3 PF10236.9 EFC46634.1 - 0.084 12.0 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 UCH PF00443.29 EFC46635.1 - 9.5e-57 192.4 9.5 1.1e-56 192.2 9.5 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC46635.1 - 1.6e-31 110.1 13.1 1.9e-31 109.9 13.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GlutR_dimer PF00745.20 EFC46635.1 - 0.1 13.1 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain EMP70 PF02990.16 EFC46636.1 - 9.6e-193 641.5 8.4 9.6e-193 641.5 8.4 1.5 2 0 0 2 2 2 1 Endomembrane protein 70 RELT PF12606.8 EFC46636.1 - 0.098 11.7 0.0 0.098 11.7 0.0 3.3 3 0 0 3 3 3 0 Tumour necrosis factor receptor superfamily member 19 RCC1 PF00415.18 EFC46637.1 - 5.3e-17 62.2 0.2 2.1e-06 28.3 0.0 4.7 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46637.1 - 1.1e-11 44.1 10.1 0.0085 15.9 0.2 5.2 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat DUF3846 PF12957.7 EFC46637.1 - 0.093 13.1 0.0 0.59 10.5 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3846) ATP-grasp_2 PF08442.10 EFC46638.1 - 7.2e-71 237.9 0.5 1.3e-69 233.9 0.1 2.1 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 EFC46638.1 - 1.4e-26 93.1 1.3 2.6e-26 92.3 1.3 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 EFC46638.1 - 2.3e-11 43.6 0.2 9.2e-10 38.3 0.1 2.3 2 0 0 2 2 2 1 ATP-grasp domain Succ_CoA_lig PF13607.6 EFC46638.1 - 0.0031 17.3 0.1 0.0056 16.5 0.1 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain OKR_DC_1_N PF03709.15 EFC46638.1 - 0.0087 16.3 0.3 2.6 8.3 0.0 2.4 1 1 1 2 2 2 2 Orn/Lys/Arg decarboxylase, N-terminal domain Endonuc-MspI PF09208.10 EFC46638.1 - 0.07 12.5 0.1 0.59 9.5 0.0 2.3 2 0 0 2 2 2 0 Restriction endonuclease MspI Aminotran_3 PF00202.21 EFC46639.1 - 7.8e-41 140.1 0.0 1e-40 139.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 EFC46639.1 - 0.0037 16.5 0.0 0.0092 15.2 0.0 1.6 1 0 0 1 1 1 1 Aminotransferase class I and II DHHC PF01529.20 EFC46640.1 - 1.6e-36 125.4 11.4 1.6e-36 125.4 11.4 2.2 2 1 0 2 2 2 1 DHHC palmitoyltransferase Phytochelatin PF05023.14 EFC46641.1 - 5.5e-88 293.7 0.1 6.3e-88 293.5 0.1 1.0 1 0 0 1 1 1 1 Phytochelatin synthase Peptidase_C39_2 PF13529.6 EFC46641.1 - 0.0075 16.8 0.0 0.021 15.4 0.0 1.7 1 1 0 1 1 1 1 Peptidase_C39 like family EF-hand_1 PF00036.32 EFC46642.1 - 1.8e-20 70.9 5.3 0.00013 21.3 0.4 5.2 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 EFC46642.1 - 4.6e-19 68.6 0.9 3.6e-09 36.9 0.1 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC46642.1 - 3.9e-17 60.7 3.8 6e-05 22.7 0.0 4.8 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 EFC46642.1 - 2.1e-13 49.9 1.4 0.00025 20.8 0.0 4.2 3 1 1 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 EFC46642.1 - 4.1e-13 48.2 7.6 0.00014 21.2 0.0 4.9 4 1 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 EFC46642.1 - 0.00026 21.2 0.0 1.4 9.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC46642.1 - 0.00032 21.0 0.1 0.44 10.9 0.2 3.2 2 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region UPF0058 PF01893.16 EFC46642.1 - 0.037 14.3 0.1 0.14 12.5 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0058 DUF1398 PF07166.11 EFC46642.1 - 0.042 13.9 0.2 12 6.0 0.0 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF1398) DUF3368 PF11848.8 EFC46642.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3368) Rhodanese PF00581.20 EFC46643.1 - 1.2e-11 45.0 0.1 5.2e-10 39.8 0.1 2.1 1 1 0 1 1 1 1 Rhodanese-like domain MTS PF05175.14 EFC46644.1 - 8.2e-06 25.5 0.0 5.3e-05 22.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 EFC46644.1 - 0.00018 22.5 0.0 0.00042 21.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain rRNA_methylase PF06962.12 EFC46644.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 Putative rRNA methylase PCMT PF01135.19 EFC46644.1 - 0.023 14.4 0.0 0.034 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ras PF00071.22 EFC46645.1 - 4.8e-26 91.3 2.8 9.3e-24 83.8 0.1 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 EFC46645.1 - 6.9e-14 52.1 2.0 2.3e-10 40.7 0.0 2.8 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Cleaved_Adhesin PF07675.11 EFC46645.1 - 0.012 15.6 0.1 0.016 15.2 0.1 1.1 1 0 0 1 1 1 0 Cleaved Adhesin Domain Arf PF00025.21 EFC46645.1 - 0.017 14.6 0.1 0.24 10.9 0.0 2.0 1 1 1 2 2 2 0 ADP-ribosylation factor family Actin PF00022.19 EFC46646.1 - 4.1e-105 351.7 0.1 3.6e-104 348.6 0.1 1.9 1 1 0 1 1 1 1 Actin tRNA-synt_1d PF00750.19 EFC46646.1 - 0.14 11.1 0.1 0.61 9.0 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (R) RmlD_sub_bind PF04321.17 EFC46647.1 - 0.023 13.8 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.21 EFC46647.1 - 0.06 12.8 0.1 0.08 12.4 0.1 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family S-AdoMet_synt_C PF02773.16 EFC46648.1 - 1.1e-68 229.5 0.2 3.6e-68 227.9 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 EFC46648.1 - 1.7e-45 154.2 0.0 2.9e-45 153.4 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 EFC46648.1 - 6.9e-43 145.4 0.2 1.3e-42 144.5 0.2 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 EFC46648.1 - 0.11 11.3 0.2 0.5 9.1 0.2 1.9 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) Abhydrolase_1 PF00561.20 EFC46650.1 - 8.8e-11 41.9 0.0 2.3e-05 24.2 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC46650.1 - 2.7e-10 40.1 0.0 3e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFC46650.1 - 8.8e-10 38.2 0.0 1.1e-05 24.8 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 EFC46650.1 - 1.9e-07 30.8 0.0 3.5e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 EFC46650.1 - 3.8e-06 26.9 0.1 1.1e-05 25.4 0.1 1.7 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DUF818 PF05677.12 EFC46650.1 - 0.0037 16.3 0.1 0.0057 15.6 0.1 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.13 EFC46650.1 - 0.0047 16.6 0.0 0.007 16.1 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) LIP PF03583.14 EFC46650.1 - 0.019 14.3 0.1 0.25 10.6 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase Asp2 PF16929.5 EFC46650.1 - 0.038 13.0 0.0 0.057 12.4 0.0 1.2 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter BAAT_C PF08840.11 EFC46650.1 - 0.048 13.6 0.0 0.66 9.9 0.0 2.1 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 EFC46650.1 - 0.1 12.2 0.0 3.8 7.0 0.0 2.1 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Ras PF00071.22 EFC46651.1 - 5.2e-49 166.0 0.0 6.5e-49 165.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46651.1 - 2e-22 79.6 0.0 2.8e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46651.1 - 1.3e-07 31.2 0.0 1.7e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family zf-CCCH PF00642.24 EFC46652.1 - 1e-05 25.3 10.2 1.3e-05 25.0 3.0 2.6 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 EFC46652.1 - 2.2e-05 24.1 9.8 0.00012 21.7 3.4 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 EFC46652.1 - 4.6e-05 24.1 0.4 4.6e-05 24.1 0.4 2.0 2 1 0 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 EFC46652.1 - 0.00037 20.5 10.6 0.0015 18.5 6.6 2.6 2 1 0 2 2 2 1 Zinc finger domain zf-CCCH_2 PF14608.6 EFC46652.1 - 0.0012 19.3 4.0 0.0012 19.3 4.0 2.5 3 0 0 3 3 3 1 RNA-binding, Nab2-type zinc finger CHZ PF09649.10 EFC46653.1 - 1e-07 31.3 0.9 1e-07 31.3 0.9 2.1 2 0 0 2 2 2 1 Histone chaperone domain CHZ Usp PF00582.26 EFC46653.1 - 1.3 9.5 5.0 0.34 11.4 0.5 1.9 1 1 1 2 2 2 0 Universal stress protein family PNP_phzG_C PF10590.9 EFC46654.1 - 1.3e-09 38.0 0.1 2.4e-09 37.1 0.1 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 EFC46654.1 - 3.4e-09 36.8 0.0 4.8e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase IBR PF01485.21 EFC46654.1 - 0.069 13.4 2.2 0.21 11.8 0.1 2.4 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain PX PF00787.24 EFC46655.1 - 1.9e-06 27.8 2.3 3.6e-06 26.9 2.3 1.4 1 0 0 1 1 1 1 PX domain DUF943 PF06092.12 EFC46656.1 - 0.061 13.0 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 Enterobacterial putative membrane protein (DUF943) Ferric_reduct PF01794.19 EFC46657.1 - 3.4e-18 66.0 11.5 3.4e-18 66.0 11.5 2.3 2 1 0 2 2 2 1 Ferric reductase like transmembrane component DOMON PF03351.17 EFC46657.1 - 4.2e-17 62.5 0.1 1.1e-16 61.1 0.1 1.7 1 0 0 1 1 1 1 DOMON domain NAD_binding_6 PF08030.12 EFC46657.1 - 1e-14 54.9 0.4 2.4e-13 50.5 0.4 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 EFC46657.1 - 1.7e-06 28.7 0.0 3e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 EFC46657.1 - 2.5e-05 24.3 0.1 0.00012 22.1 0.0 2.2 2 0 0 2 2 2 1 FAD-binding domain F-box-like PF12937.7 EFC46658.1 - 0.013 15.3 0.2 0.035 14.0 0.2 1.7 1 0 0 1 1 1 0 F-box-like Abhydrolase_1 PF00561.20 EFC46659.1 - 1.9e-11 44.1 0.0 0.00025 20.8 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC46659.1 - 2.4e-08 33.6 0.0 0.0055 16.0 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 GPS PF01825.21 EFC46659.1 - 8.3e-08 32.6 5.9 8.3e-08 32.6 5.9 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif RGS PF00615.19 EFC46659.1 - 1.7e-05 25.0 4.1 2e-05 24.8 2.1 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain Chordopox_A13L PF05961.11 EFC46659.1 - 0.077 13.2 1.8 0.39 11.0 0.1 3.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein EGF_2 PF07974.13 EFC46659.1 - 1.5 9.3 11.9 0.064 13.6 5.8 1.9 2 0 0 2 2 2 0 EGF-like domain AT_hook PF02178.19 EFC46660.1 - 0.11 12.4 2.3 0.2 11.6 2.3 1.4 1 0 0 1 1 1 0 AT hook motif Dsh_C PF12316.8 EFC46661.1 - 3.6 8.0 21.6 2.3 8.6 10.9 2.4 2 1 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Actin PF00022.19 EFC46662.1 - 2.7e-144 480.8 0.0 1.1e-143 478.7 0.0 1.7 1 1 0 1 1 1 1 Actin NHL PF01436.21 EFC46663.1 - 1.4e-06 28.0 0.0 0.072 13.2 0.0 3.6 3 0 0 3 3 3 2 NHL repeat Lactonase PF10282.9 EFC46663.1 - 0.014 14.6 0.0 1.1 8.4 0.0 2.2 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller TolB_like PF15869.5 EFC46663.1 - 0.065 12.5 1.4 1.2 8.3 0.3 2.6 1 1 1 2 2 2 0 TolB-like 6-blade propeller-like ubiquitin PF00240.23 EFC46664.1 - 1.9e-47 158.9 5.4 3.2e-30 103.7 0.9 2.0 1 1 1 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC46664.1 - 2.8e-20 71.9 4.9 9.1e-13 47.9 1.0 2.0 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC46664.1 - 1.3e-08 35.2 1.7 0.0017 18.8 0.5 2.6 1 1 1 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC46664.1 - 2.4e-08 33.8 0.1 0.0027 17.6 0.0 2.1 1 1 1 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFC46664.1 - 4.5e-05 23.9 0.1 0.0086 16.6 0.0 2.1 1 1 1 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC46664.1 - 0.00012 22.2 0.3 0.0019 18.3 0.1 2.5 1 1 1 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC46664.1 - 0.0003 21.1 1.2 0.012 15.9 0.1 2.0 1 1 1 2 2 2 1 Ubiquitin-like domain Raf1_HTH PF18579.1 EFC46664.1 - 0.0052 16.5 0.1 3.5 7.4 0.0 2.3 2 0 0 2 2 2 2 Rubisco accumulation factor 1 helix turn helix domain Ubiquitin_4 PF18036.1 EFC46664.1 - 0.013 15.5 3.4 8.8 6.5 0.1 3.0 2 1 1 3 3 3 0 Ubiquitin-like domain Coagulin PF02035.15 EFC46664.1 - 0.027 14.4 0.8 1 9.2 0.1 2.1 1 1 1 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC46664.1 - 0.057 13.6 0.5 2.6 8.3 0.1 2.2 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) DUF1866 PF08952.11 EFC46664.1 - 0.059 13.2 1.0 3.2 7.6 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1866) UN_NPL4 PF11543.8 EFC46664.1 - 0.065 13.7 0.6 4.2 7.9 0.1 2.2 1 1 1 2 2 2 0 Nuclear pore localisation protein NPL4 ProRS-C_2 PF09181.10 EFC46664.1 - 0.19 11.9 1.1 6.6 7.0 0.3 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 EFC46664.1 - 4.6 7.5 5.2 5.5 7.3 0.2 2.3 2 0 0 2 2 2 0 Tash protein PEST motif Actin PF00022.19 EFC46665.1 - 4.8e-61 206.6 0.0 2.4e-60 204.2 0.0 1.8 1 1 0 1 1 1 1 Actin dCMP_cyt_deam_1 PF00383.23 EFC46667.1 - 4.5e-22 77.8 0.2 4.5e-22 77.8 0.2 2.1 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFC46667.1 - 2e-14 53.5 0.1 2e-14 53.5 0.1 1.6 2 0 0 2 2 2 1 MafB19-like deaminase SNAD4 PF18750.1 EFC46667.1 - 4.2e-05 23.6 0.1 7.6e-05 22.8 0.1 1.5 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD2 PF18782.1 EFC46667.1 - 0.0016 18.6 0.1 0.0019 18.3 0.1 1.3 1 0 0 1 1 1 1 Novel AID APOBEC clade 2 NAD1 PF18778.1 EFC46667.1 - 0.0018 18.4 0.1 0.0031 17.6 0.1 1.3 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 EFC46667.1 - 0.0035 17.4 0.0 0.0055 16.8 0.0 1.3 1 0 0 1 1 1 1 APOBEC2 APOBEC_N PF08210.11 EFC46667.1 - 0.0063 16.4 0.7 0.0081 16.1 0.7 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC4_like PF18774.1 EFC46667.1 - 0.013 15.4 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase APOBEC1 PF18769.1 EFC46667.1 - 0.036 14.3 0.1 0.068 13.4 0.1 1.5 1 0 0 1 1 1 0 APOBEC1 APOBEC3 PF18771.1 EFC46667.1 - 0.049 13.7 0.1 0.095 12.8 0.1 1.4 1 0 0 1 1 1 0 APOBEC3 OTT_1508_deam PF14441.6 EFC46667.1 - 0.19 11.8 2.8 3.2 7.8 0.1 2.6 2 0 0 2 2 2 0 OTT_1508-like deaminase Bd3614-deam PF14439.6 EFC46667.1 - 1.1 9.3 9.4 1.4 9.0 0.6 3.0 2 1 1 3 3 3 0 Bd3614-like deaminase hSac2 PF12456.8 EFC46668.1 - 0.014 15.1 0.1 0.024 14.4 0.1 1.4 1 0 0 1 1 1 0 Inositol phosphatase RGS PF00615.19 EFC46670.1 - 6.8e-06 26.3 3.7 6.8e-06 26.3 3.7 2.5 3 0 0 3 3 3 1 Regulator of G protein signaling domain Enterotoxin_b PF01376.18 EFC46670.1 - 0.022 14.9 0.0 0.98 9.7 0.0 3.0 2 0 0 2 2 2 0 Heat-labile enterotoxin beta chain DUF4407 PF14362.6 EFC46670.1 - 0.11 11.8 0.1 0.11 11.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Peptidase_S8 PF00082.22 EFC46671.1 - 4.7e-40 137.7 2.1 1.8e-39 135.8 2.1 2.0 1 1 0 1 1 1 1 Subtilase family Med12-PQL PF12144.8 EFC46672.1 - 0.085 12.7 0.1 0.11 12.4 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic Mediator 12 catenin-binding domain TMEM154 PF15102.6 EFC46672.1 - 0.093 12.6 1.0 0.14 12.0 1.0 1.4 1 1 0 1 1 1 0 TMEM154 protein family Trypan_PARP PF05887.11 EFC46673.1 - 1.4e-05 25.0 69.1 0.00022 21.2 35.6 2.3 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) Presenilin PF01080.17 EFC46673.1 - 7.7 5.2 14.9 7.4 5.2 14.9 1.1 1 0 0 1 1 1 0 Presenilin Trypan_PARP PF05887.11 EFC46674.1 - 4.9e-05 23.3 67.8 0.0068 16.4 34.5 2.0 1 1 1 2 2 2 2 Procyclic acidic repetitive protein (PARP) PARP PF00644.20 EFC46675.1 - 3.2e-10 39.9 0.1 5.7e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Phage_int_SAM_3 PF14659.6 EFC46675.1 - 0.48 10.7 4.6 0.15 12.4 1.0 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain PdaC PF13739.6 EFC46675.1 - 6.2 7.9 6.7 2.7 9.0 0.3 2.8 2 1 1 3 3 3 0 Deacetylase PdaC Pkinase PF00069.25 EFC46676.1 - 3.5e-35 121.6 0.1 5.8e-35 120.9 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46676.1 - 8.7e-34 117.0 0.1 1.3e-33 116.4 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pentapeptide_4 PF13599.6 EFC46676.1 - 0.0056 16.8 4.7 0.51 10.6 0.9 3.0 2 0 0 2 2 2 2 Pentapeptide repeats (9 copies) APH PF01636.23 EFC46676.1 - 0.0058 16.6 0.0 0.011 15.7 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC46676.1 - 0.014 14.2 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase TMEMspv1-c74-12 PF11044.8 EFC46676.1 - 0.042 13.8 3.2 0.11 12.5 3.2 1.7 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein EMC3_TMCO1 PF01956.16 EFC46676.1 - 0.064 13.0 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LapA_dom PF06305.11 EFC46676.1 - 0.072 12.9 0.9 0.21 11.4 0.9 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain UPF0172 PF03665.13 EFC46676.1 - 0.34 10.9 2.0 1.6 8.8 0.1 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0172) DUF3139 PF11337.8 EFC46676.1 - 1.2 9.8 8.2 1.5 9.5 0.3 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3139) DUF5362 PF17319.2 EFC46676.1 - 5.8 6.8 8.1 0.21 11.4 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5362) Pkinase_Tyr PF07714.17 EFC46677.1 - 4.7e-05 22.8 0.0 0.01 15.2 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase BTB_2 PF02214.22 EFC46678.1 - 9.1e-20 70.8 0.7 2.7e-19 69.3 0.0 2.0 2 0 0 2 2 2 1 BTB/POZ domain TPR_MLP1_2 PF07926.12 EFC46678.1 - 0.00012 22.1 5.1 0.00023 21.2 5.1 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Peptidase_A4 PF01828.17 EFC46678.1 - 0.0096 15.4 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase A4 family HTH_Tnp_IS630 PF01710.16 EFC46678.1 - 0.059 13.4 0.5 0.14 12.2 0.5 1.6 1 0 0 1 1 1 0 Transposase FAD_binding_3 PF01494.19 EFC46679.1 - 0.00047 19.5 0.0 0.028 13.7 0.0 2.4 2 1 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 EFC46679.1 - 0.0013 17.7 0.1 0.77 8.5 0.0 3.0 3 0 0 3 3 3 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 EFC46679.1 - 0.0015 17.8 0.1 0.32 10.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC46679.1 - 0.017 14.8 0.6 0.74 9.3 0.0 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase SE PF08491.10 EFC46679.1 - 0.028 13.5 0.0 0.063 12.3 0.0 1.5 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox PF00070.27 EFC46679.1 - 0.1 13.2 0.3 0.9 10.1 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Cas_Csn2 PF09711.10 EFC46680.1 - 0.024 14.3 4.6 0.055 13.1 4.6 1.6 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Csn2) FAD_binding_1 PF00667.20 EFC46680.1 - 0.04 13.5 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Glyco_hydro_63 PF03200.16 EFC46681.1 - 1.8e-75 254.6 24.4 2.9e-52 178.0 5.9 2.7 2 1 1 3 3 3 2 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 EFC46681.1 - 3.2e-09 37.2 0.8 3.2e-09 37.2 0.8 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain BORA_N PF15280.6 EFC46681.1 - 0.027 14.1 2.8 0.051 13.2 2.8 1.3 1 0 0 1 1 1 0 Protein aurora borealis N-terminus CR6_interact PF10147.9 EFC46681.1 - 0.13 12.0 2.0 0.43 10.3 0.0 2.4 2 1 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Ifi-6-16 PF06140.13 EFC46682.1 - 1.6e-13 50.4 25.8 3.2e-13 49.4 25.8 1.5 1 0 0 1 1 1 1 Interferon-induced 6-16 family XRCC4 PF06632.12 EFC46682.1 - 0.57 9.0 2.0 0.99 8.2 2.0 1.3 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 ISK_Channel PF02060.15 EFC46682.1 - 0.96 9.2 3.3 0.47 10.2 0.3 2.0 2 0 0 2 2 2 0 Slow voltage-gated potassium channel DUF4116 PF13475.6 EFC46683.1 - 5e-65 215.0 49.9 3.8e-10 39.3 0.1 14.3 7 6 6 14 14 14 11 Domain of unknown function (DUF4116) HTH_10 PF04967.12 EFC46683.1 - 0.076 12.8 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 HTH DNA binding domain NUP50 PF08911.11 EFC46683.1 - 0.16 12.7 0.0 0.31 11.7 0.0 1.4 1 0 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) Gelsolin PF00626.22 EFC46684.1 - 1.9e-41 139.8 3.9 2.5e-11 43.3 0.0 5.7 5 0 0 5 5 5 5 Gelsolin repeat RRM_1 PF00076.22 EFC46684.1 - 4e-24 84.2 0.4 1.5e-14 53.5 0.1 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VHP PF02209.19 EFC46684.1 - 2.9e-13 49.6 2.5 1.1e-12 47.8 2.5 2.1 1 0 0 1 1 1 1 Villin headpiece domain WD40_4 PF16300.5 EFC46684.1 - 6.9e-12 45.1 0.1 1.7e-11 43.8 0.1 1.7 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.11 EFC46684.1 - 3.6e-11 42.8 0.8 1.8e-10 40.6 0.2 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1899) WD40 PF00400.32 EFC46684.1 - 2.2e-07 31.4 13.0 0.00095 19.9 0.2 5.4 5 0 0 5 5 5 2 WD domain, G-beta repeat PH PF00169.29 EFC46684.1 - 2.6e-07 31.1 10.0 0.00023 21.6 1.3 3.4 3 0 0 3 3 3 2 PH domain RRM_3 PF08777.11 EFC46684.1 - 0.0043 17.1 2.2 0.31 11.1 0.0 3.3 3 0 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 EFC46684.1 - 0.0058 16.6 0.0 5.1 7.2 0.0 2.9 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif BAG PF02179.16 EFC46685.1 - 3.7e-17 62.5 6.8 8.2e-17 61.4 6.8 1.6 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 EFC46685.1 - 3.5e-10 39.5 1.9 8e-10 38.3 1.9 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EFC46685.1 - 0.00028 21.4 5.8 0.00093 19.7 5.8 2.1 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EFC46685.1 - 0.0036 17.1 0.5 0.0082 16.0 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBX PF00789.20 EFC46685.1 - 0.017 15.3 0.3 0.038 14.2 0.3 1.6 1 0 0 1 1 1 0 UBX domain DUF883 PF05957.13 EFC46685.1 - 0.71 10.5 6.2 0.43 11.2 2.1 2.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) Cullin PF00888.22 EFC46686.1 - 5.8e-152 507.5 34.1 9e-152 506.8 34.1 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFC46686.1 - 2.2e-26 91.7 2.8 2.2e-26 91.7 2.8 3.1 3 0 0 3 3 3 1 Cullin protein neddylation domain Exo_endo_phos PF03372.23 EFC46687.1 - 1.6e-16 60.5 0.0 2.7e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Glyco_trans_4_2 PF13477.6 EFC46687.1 - 0.065 13.3 0.2 0.35 10.9 0.1 2.1 1 1 1 2 2 2 0 Glycosyl transferase 4-like Actin PF00022.19 EFC46689.1 - 2.4e-141 471.1 0.0 8e-141 469.3 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC46689.1 - 0.0023 16.8 0.0 0.015 14.1 0.1 2.1 2 1 0 2 2 2 1 MreB/Mbl protein p450 PF00067.22 EFC46693.1 - 4e-64 217.1 0.6 5.3e-64 216.7 0.6 1.1 1 0 0 1 1 1 1 Cytochrome P450 HEPPP_synt_1 PF07307.11 EFC46693.1 - 0.063 12.9 0.5 12 5.4 0.5 2.2 2 0 0 2 2 2 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Arf PF00025.21 EFC46694.1 - 6e-56 188.6 0.0 1.3e-55 187.5 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC46694.1 - 5.3e-15 55.4 0.0 1.1e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46694.1 - 1.6e-11 44.5 0.0 3.4e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC46694.1 - 1.1e-09 37.9 0.1 1.8e-05 24.1 0.1 2.7 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC46694.1 - 3.1e-08 33.2 0.8 1.7e-07 30.9 0.0 2.4 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFC46694.1 - 2e-06 27.4 0.0 6.8e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit BTB PF00651.31 EFC46694.1 - 0.00031 20.9 0.1 0.00088 19.5 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain MatE PF01554.18 EFC46695.1 - 5.9e-47 159.3 34.7 1.2e-24 86.8 7.5 3.0 4 0 0 4 4 4 2 MatE Polysacc_synt_C PF14667.6 EFC46695.1 - 0.00019 21.5 41.7 0.00026 21.0 17.5 4.2 4 1 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain UPF0242 PF06785.11 EFC46695.1 - 0.005 17.0 0.0 0.005 17.0 0.0 2.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus DUF2207 PF09972.9 EFC46695.1 - 0.0095 14.7 18.6 0.065 12.0 7.5 3.6 3 0 0 3 3 3 3 Predicted membrane protein (DUF2207) Proton_antipo_N PF00662.20 EFC46695.1 - 0.15 12.2 3.2 5.7 7.1 1.0 3.1 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus BBS1 PF14779.6 EFC46696.1 - 5e-76 255.5 0.0 4.1e-73 246.0 0.0 2.3 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 1 BBS2_Mid PF14783.6 EFC46696.1 - 0.00039 20.4 0.7 3.4 7.7 0.0 4.3 3 2 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region RAB3GAP2_N PF14655.6 EFC46696.1 - 0.0039 16.5 0.0 0.09 12.0 0.0 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus IKI3 PF04762.12 EFC46696.1 - 0.042 11.9 0.0 0.51 8.3 0.0 2.0 1 1 0 1 1 1 0 IKI3 family Casein PF00363.18 EFC46696.1 - 0.4 11.1 2.1 1.6 9.1 0.4 2.4 2 0 0 2 2 2 0 Casein bZIP_2 PF07716.15 EFC46697.1 - 0.02 14.9 0.3 0.02 14.9 0.3 3.1 3 1 1 4 4 4 0 Basic region leucine zipper DUF4709 PF15821.5 EFC46697.1 - 0.056 13.7 4.2 0.084 13.2 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4709) BCDHK_Adom3 PF10436.9 EFC46697.1 - 0.057 13.3 1.8 0.071 12.9 1.8 1.1 1 0 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase SpecificRecomb PF10136.9 EFC46697.1 - 0.16 10.2 0.7 0.18 10.1 0.7 1.1 1 0 0 1 1 1 0 Site-specific recombinase HJURP_C PF12347.8 EFC46697.1 - 0.2 11.7 2.5 0.34 11.0 0.7 2.2 1 1 1 2 2 2 0 Holliday junction regulator protein family C-terminal repeat DUF745 PF05335.13 EFC46697.1 - 0.24 11.1 3.1 0.34 10.6 3.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Uds1 PF15456.6 EFC46697.1 - 0.31 11.2 7.6 0.27 11.4 6.5 1.5 1 1 1 2 2 2 0 Up-regulated During Septation PRP1_N PF06424.12 EFC46697.1 - 0.44 10.9 8.4 0.61 10.5 8.4 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF4083 PF13314.6 EFC46697.1 - 0.56 10.2 6.3 2.9 7.9 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) ATP_bind_1 PF03029.17 EFC46697.1 - 0.98 9.1 4.2 0.97 9.2 1.1 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein ABC_tran_CTD PF16326.5 EFC46697.1 - 1.8 8.9 10.5 1.6 9.0 2.7 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain COX16 PF14138.6 EFC46697.1 - 2.5 8.7 5.6 5.2 7.7 5.5 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 HSP70 PF00012.20 EFC46699.1 - 7.7e-10 37.6 0.4 1.3e-09 36.9 0.4 1.3 1 0 0 1 1 1 1 Hsp70 protein CDC45 PF02724.14 EFC46699.1 - 0.0011 17.4 0.9 0.0015 16.9 0.9 1.2 1 0 0 1 1 1 1 CDC45-like protein BUD22 PF09073.10 EFC46699.1 - 0.1 11.9 4.8 0.18 11.1 4.8 1.3 1 0 0 1 1 1 0 BUD22 HSP70 PF00012.20 EFC46700.1 - 1.6e-14 53.1 1.0 3e-14 52.1 1.0 1.4 1 0 0 1 1 1 1 Hsp70 protein VWA_3 PF13768.6 EFC46700.1 - 0.00092 19.2 0.0 0.0019 18.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain FGGY_C PF02782.16 EFC46700.1 - 0.037 13.7 0.0 0.071 12.8 0.0 1.4 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain RCC1_2 PF13540.6 EFC46701.1 - 1.1e-13 50.6 3.2 5.3e-06 26.1 0.1 5.2 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC46701.1 - 1.2e-12 48.3 0.6 0.003 18.2 0.0 5.0 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat Gelsolin PF00626.22 EFC46702.1 - 2.5e-26 91.4 2.6 6.3e-06 26.0 0.0 4.7 4 0 0 4 4 4 4 Gelsolin repeat VHP PF02209.19 EFC46702.1 - 1.8e-13 50.3 6.0 1.8e-13 50.3 6.0 2.6 2 0 0 2 2 2 1 Villin headpiece domain WD40_4 PF16300.5 EFC46702.1 - 3.3e-08 33.3 0.0 1.1e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 Type of WD40 repeat DUF1899 PF08953.11 EFC46702.1 - 2.3e-07 30.6 0.0 2.3e-07 30.6 0.0 3.4 5 0 0 5 5 5 1 Domain of unknown function (DUF1899) WD40 PF00400.32 EFC46702.1 - 0.0013 19.5 0.2 0.3 12.0 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC46702.1 - 0.0037 17.5 0.0 0.7 10.2 0.0 3.7 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SelP_N PF04592.14 EFC46702.1 - 1.3 8.4 10.7 3.4 7.0 10.7 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SIMPL PF04402.14 EFC46703.1 - 1.8e-20 74.3 1.1 2.5e-20 73.8 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF5304 PF17230.2 EFC46703.1 - 0.082 13.1 0.4 0.17 12.1 0.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5304) Neurensin PF14927.6 EFC46703.1 - 0.096 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Neurensin LZ3wCH PF18517.1 EFC46704.1 - 1.1e-20 73.4 0.6 5.1e-20 71.3 0.6 2.2 1 0 0 1 1 1 1 Leucine zipper with capping helix domain Mnd1 PF03962.15 EFC46704.1 - 6.9e-20 71.1 0.0 2.5e-19 69.3 0.0 2.0 1 0 0 1 1 1 1 Mnd1 HTH domain FapA PF03961.13 EFC46704.1 - 0.021 13.5 3.6 0.023 13.3 3.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A PEHE PF15275.6 EFC46705.1 - 0.0015 19.2 5.8 0.0015 19.2 5.8 6.9 5 3 1 6 6 6 1 PEHE domain HMD PF03201.16 EFC46705.1 - 0.13 12.5 0.1 0.37 11.0 0.1 1.7 1 0 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Tmemb_14 PF03647.13 EFC46706.1 - 1.7e-20 73.5 8.0 1.9e-20 73.4 8.0 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Phage_holin_5_2 PF16079.5 EFC46706.1 - 0.025 14.9 3.0 0.039 14.3 0.3 2.2 1 1 1 2 2 2 0 Phage holin family Hol44, in holin superfamily V Kinesin PF00225.23 EFC46707.1 - 8.6e-98 327.3 14.6 8.6e-98 327.3 14.6 4.8 3 2 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 EFC46707.1 - 1.9e-25 89.6 0.8 1.9e-25 89.6 0.8 3.8 2 1 0 4 4 4 1 Microtubule binding PEPCK_ATP PF01293.20 EFC46708.1 - 9.7e-215 713.6 0.0 1.1e-214 713.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 EFC46708.1 - 0.23 11.8 0.0 0.42 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain PCI PF01399.27 EFC46710.1 - 1.7e-08 34.9 0.0 3.6e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 PCI domain Mastoparan_2 PF08251.11 EFC46710.1 - 0.097 12.9 0.2 0.39 11.0 0.2 2.1 1 0 0 1 1 1 0 Mastoparan peptide MFS_1 PF07690.16 EFC46711.1 - 1.1e-25 90.4 9.0 1.1e-25 90.4 9.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily V_ATPase_I PF01496.19 EFC46711.1 - 0.0063 14.5 10.3 0.018 13.0 10.3 1.7 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family Peptidase_S30 PF01577.16 EFC46711.1 - 0.61 9.7 2.3 0.98 9.0 2.3 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease SPC25 PF06703.11 EFC46711.1 - 1.5 8.6 7.7 3.6 7.4 0.7 2.8 3 0 0 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Pkinase_Tyr PF07714.17 EFC46712.1 - 4.6e-66 222.7 0.1 7.4e-66 222.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC46712.1 - 1.7e-57 194.8 0.3 3.9e-57 193.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain PBP_like_2 PF12849.7 EFC46712.1 - 3.1e-08 33.6 0.0 9.6e-08 32.0 0.0 1.6 1 1 0 1 1 1 1 PBP superfamily domain pEK499_p136 PF18736.1 EFC46712.1 - 0.0045 16.6 1.2 0.13 11.8 0.2 2.8 1 1 1 2 2 2 1 HEPN pEK499 p136 APH PF01636.23 EFC46712.1 - 0.054 13.4 0.0 0.085 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC46712.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Kinase-like F-box-like PF12937.7 EFC46713.1 - 0.015 15.2 0.1 0.032 14.1 0.1 1.6 1 0 0 1 1 1 0 F-box-like Terminase_4 PF05119.12 EFC46713.1 - 0.17 12.4 0.0 0.56 10.7 0.0 1.8 1 0 0 1 1 1 0 Phage terminase, small subunit Cytochrom_B558a PF05038.13 EFC46714.1 - 0.05 13.2 5.5 0.12 11.9 5.5 1.7 1 1 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Bestrophin PF01062.21 EFC46714.1 - 0.066 12.6 1.1 0.14 11.5 0.9 1.4 1 1 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel AcrZ PF10766.9 EFC46714.1 - 0.12 12.0 0.8 0.33 10.6 0.8 1.7 1 0 0 1 1 1 0 Multidrug efflux pump-associated protein AcrZ DUF202 PF02656.15 EFC46714.1 - 1.9 9.0 7.5 0.74 10.3 0.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF202) 3-HAO PF06052.12 EFC46715.1 - 6.5e-62 207.6 0.6 7.6e-62 207.4 0.6 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 EFC46715.1 - 1.7e-06 27.6 0.1 2.8e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EFC46715.1 - 0.00031 20.4 0.0 0.00045 19.8 0.0 1.3 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 EFC46715.1 - 0.0011 18.8 0.0 0.0018 18.2 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Nudix_N_2 PF14803.6 EFC46715.1 - 0.019 14.9 0.9 3.4 7.7 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal DUF386 PF04074.12 EFC46715.1 - 0.031 14.2 0.1 0.042 13.8 0.1 1.2 1 0 0 1 1 1 0 YhcH/YjgK/YiaL DZR PF12773.7 EFC46715.1 - 0.045 13.8 3.3 0.074 13.1 3.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon Methyltransf_31 PF13847.6 EFC46716.1 - 8.5e-16 58.1 0.2 1.7e-15 57.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC46716.1 - 1.3e-15 57.8 0.0 3e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC46716.1 - 1e-14 55.0 0.0 2.1e-14 54.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC46716.1 - 1.2e-14 54.8 0.1 3.6e-14 53.2 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC46716.1 - 3.1e-12 46.6 0.1 1.4e-11 44.5 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain NodS PF05401.11 EFC46716.1 - 5.1e-07 29.5 0.0 1.3e-05 24.9 0.0 2.1 1 1 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 EFC46716.1 - 1.1e-06 28.2 0.2 4.8e-06 26.1 0.2 2.0 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Pox_MCEL PF03291.16 EFC46716.1 - 2e-06 27.1 0.3 3e-06 26.6 0.3 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Ubie_methyltran PF01209.18 EFC46716.1 - 0.00022 20.7 0.0 0.00036 19.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 EFC46716.1 - 0.00036 20.6 0.1 0.00065 19.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 EFC46716.1 - 0.00048 19.2 0.0 0.00076 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CheR PF01739.18 EFC46716.1 - 0.0006 19.4 0.1 0.0052 16.3 0.0 2.2 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain TehB PF03848.14 EFC46716.1 - 0.0011 18.4 0.4 0.0084 15.5 0.4 2.1 1 1 0 1 1 1 1 Tellurite resistance protein TehB MTS PF05175.14 EFC46716.1 - 0.0016 18.0 0.1 0.0032 17.0 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFC46716.1 - 0.0022 17.4 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DREV PF05219.12 EFC46716.1 - 0.0069 15.5 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase RrnaAD PF00398.20 EFC46716.1 - 0.011 14.8 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 EFC46716.1 - 0.014 14.8 0.1 0.092 12.2 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase TPMT PF05724.11 EFC46716.1 - 0.017 14.8 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_7 PF03492.15 EFC46716.1 - 0.026 13.7 1.5 0.44 9.7 0.1 2.2 1 1 0 2 2 2 0 SAM dependent carboxyl methyltransferase Methyltransf_24 PF13578.6 EFC46716.1 - 0.12 13.4 0.0 0.23 12.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 EFC46716.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) LRR_6 PF13516.6 EFC46717.1 - 1.6e-05 24.6 30.1 0.063 13.4 0.1 8.9 9 0 0 9 9 9 4 Leucine Rich repeat LRR_4 PF12799.7 EFC46717.1 - 0.95 10.0 38.6 15 6.2 1.3 10.2 8 2 2 10 10 10 0 Leucine Rich repeats (2 copies) Rcd1 PF04078.13 EFC46718.1 - 4.5e-117 389.9 0.4 5.1e-117 389.8 0.4 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Adap_comp_sub PF00928.21 EFC46719.1 - 4.4e-22 78.7 1.6 6.3e-22 78.2 1.6 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFC46719.1 - 0.007 16.3 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Thioredoxin PF00085.20 EFC46720.1 - 4.4e-22 78.0 0.0 4.7e-22 77.9 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFC46720.1 - 0.00012 22.5 0.2 0.00052 20.4 0.2 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EFC46720.1 - 0.00015 21.7 0.0 0.00018 21.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC46720.1 - 0.00024 20.9 0.2 0.00056 19.6 0.2 1.5 1 1 1 2 2 2 1 Redoxin Thioredoxin_8 PF13905.6 EFC46720.1 - 0.00026 21.3 0.0 0.00031 21.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 EFC46720.1 - 0.0023 17.3 0.0 0.0026 17.2 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Glutaredoxin PF00462.24 EFC46720.1 - 0.0051 17.0 0.0 0.007 16.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_7 PF13899.6 EFC46720.1 - 0.0054 16.9 0.0 0.0068 16.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EFC46720.1 - 0.0067 16.2 0.0 0.0076 16.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_4 PF13462.6 EFC46720.1 - 0.019 15.1 0.2 2.1 8.5 0.2 2.0 1 1 1 2 2 2 0 Thioredoxin KaiB PF07689.12 EFC46720.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 KaiB domain DUF953 PF06110.11 EFC46720.1 - 0.026 14.1 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Arabino_trans_C PF14896.6 EFC46720.1 - 0.04 12.9 0.0 1.9 7.4 0.0 2.0 2 0 0 2 2 2 0 EmbC C-terminal domain AAA_31 PF13614.6 EFC46720.1 - 0.072 13.0 0.0 0.09 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA domain T4_deiodinase PF00837.17 EFC46720.1 - 0.085 12.1 0.0 0.089 12.1 0.0 1.1 1 0 0 1 1 1 0 Iodothyronine deiodinase F-box PF00646.33 EFC46722.1 - 0.00022 21.0 0.9 0.00043 20.1 0.9 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC46722.1 - 0.00051 19.9 0.4 0.00084 19.2 0.4 1.3 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 EFC46722.1 - 0.15 12.5 8.1 0.51 10.8 0.8 2.5 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) BTB_2 PF02214.22 EFC46723.1 - 1.3e-13 51.0 0.6 4.3e-13 49.4 0.3 2.1 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 EFC46723.1 - 1e-05 25.7 2.2 0.19 12.0 0.3 3.5 2 1 0 2 2 2 2 BTB/POZ domain Pkinase_Tyr PF07714.17 EFC46725.1 - 1.3e-17 64.0 0.1 1.3e-17 63.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC46725.1 - 6.3e-14 52.0 0.2 6.9e-14 51.9 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain YvfG PF09628.10 EFC46726.1 - 0.14 12.5 0.6 0.23 11.9 0.6 1.2 1 0 0 1 1 1 0 YvfG protein Mito_carr PF00153.27 EFC46727.1 - 7.2e-72 237.4 1.6 9.3e-26 89.6 0.0 3.8 4 0 0 4 4 4 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 EFC46727.1 - 1.1e-17 64.2 4.3 2.6e-05 24.6 0.1 5.5 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_8 PF13833.6 EFC46727.1 - 1.8e-17 62.9 11.9 4.8e-06 26.3 0.4 5.5 3 2 1 4 4 4 4 EF-hand domain pair EF-hand_1 PF00036.32 EFC46727.1 - 6.5e-16 56.6 13.5 5e-07 28.8 0.8 6.3 6 0 0 6 6 6 4 EF hand EF-hand_6 PF13405.6 EFC46727.1 - 1.6e-12 46.3 11.4 1.2e-06 27.9 0.5 5.6 6 0 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 EFC46727.1 - 3e-12 45.4 1.3 1e-06 27.9 0.2 4.4 3 0 0 3 3 3 3 EF hand DUF735 PF05246.11 EFC46727.1 - 0.01 15.8 0.8 2.8 7.9 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF735) SPARC_Ca_bdg PF10591.9 EFC46727.1 - 0.14 12.4 0.2 0.5 10.7 0.1 1.9 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region SHQ1 PF04925.15 EFC46728.1 - 4.2e-53 179.5 3.9 7e-53 178.8 3.9 1.3 1 0 0 1 1 1 1 SHQ1 protein Ependymin PF00811.18 EFC46730.1 - 1.2e-05 25.5 0.0 2.9e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Ependymin CarboxypepD_reg PF13620.6 EFC46730.1 - 0.00016 21.9 0.0 0.00045 20.4 0.0 1.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFC46730.1 - 0.074 13.1 0.3 0.074 13.1 0.3 2.0 2 0 0 2 2 2 0 CarboxypepD_reg-like domain His_Phos_1 PF00300.22 EFC46732.1 - 2e-14 53.7 0.0 2.2e-12 47.1 0.0 2.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RCC1 PF00415.18 EFC46733.1 - 4.3e-13 49.6 0.7 0.0091 16.6 0.0 5.1 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC46733.1 - 2.8e-09 37.2 0.2 9.1e-09 35.5 0.2 2.0 1 0 0 1 1 1 1 BTB/POZ domain RCC1_2 PF13540.6 EFC46733.1 - 3.8e-09 36.1 10.3 0.029 14.2 0.0 5.5 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat DnaGprimase_HBD PF16730.5 EFC46733.1 - 0.0049 16.9 1.3 0.79 9.8 0.1 3.3 3 0 0 3 3 3 2 DnaG-primase C-terminal, helicase-binding domain Astro_capsid_p2 PF16580.5 EFC46734.1 - 0.0034 16.9 0.4 0.0068 15.9 0.4 1.4 1 0 0 1 1 1 1 C-terminal tail of astrovirus capsid projection or spike NpwBP PF12622.7 EFC46734.1 - 0.029 15.1 1.2 0.13 13.0 1.2 2.2 1 0 0 1 1 1 0 mRNA biogenesis factor Homeobox_KN PF05920.11 EFC46735.1 - 5.8e-17 61.3 5.6 2.2e-16 59.4 3.5 2.6 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 EFC46735.1 - 2e-07 30.8 2.0 2e-07 30.8 2.0 3.0 2 0 0 2 2 2 1 Homeodomain Pallilysin PF18663.1 EFC46735.1 - 0.017 15.1 0.2 0.044 13.8 0.2 1.6 1 0 0 1 1 1 0 Pallilysin beta barrel domain YqzH PF14164.6 EFC46735.1 - 0.068 13.2 0.2 0.35 11.0 0.2 2.3 1 0 0 1 1 1 0 YqzH-like protein Cnd1_N PF12922.7 EFC46735.1 - 8.8 6.1 13.9 0.031 14.1 3.0 2.4 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1, N-term TatC PF00902.18 EFC46737.1 - 0.16 11.8 3.3 0.45 10.3 3.3 1.8 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) Cation_ATPase_C PF00689.21 EFC46737.1 - 0.61 9.8 4.9 18 5.0 3.1 2.6 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus DUF4834 PF16118.5 EFC46737.1 - 6 7.9 5.6 6.6 7.8 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) RasGEF PF00617.19 EFC46738.1 - 9.2e-52 175.8 1.1 3.4e-51 174.0 1.1 2.1 1 0 0 1 1 1 1 RasGEF domain DOCK-C2 PF14429.6 EFC46738.1 - 4.5e-31 108.2 1.5 3.2e-30 105.4 0.8 2.8 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins RasGEF_N PF00618.20 EFC46738.1 - 7.3e-18 64.7 1.3 7.3e-18 64.7 1.3 4.0 3 0 0 3 3 3 1 RasGEF N-terminal motif QRPTase_C PF01729.19 EFC46739.1 - 5.8e-48 162.9 0.1 8.1e-48 162.4 0.1 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 EFC46739.1 - 5.1e-09 36.1 0.0 0.00042 20.3 0.0 2.5 2 0 0 2 2 2 2 Quinolinate phosphoribosyl transferase, N-terminal domain PRAI PF00697.22 EFC46739.1 - 0.078 12.7 0.0 0.79 9.5 0.0 2.1 2 0 0 2 2 2 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase DAGK_cat PF00781.24 EFC46740.1 - 1.5e-09 37.5 0.9 2.3e-09 37.0 0.2 1.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain NAD_kinase PF01513.21 EFC46740.1 - 0.023 13.9 0.1 0.052 12.7 0.1 1.5 1 0 0 1 1 1 0 ATP-NAD kinase ABC2_membrane_3 PF12698.7 EFC46740.1 - 0.039 13.1 0.2 0.059 12.5 0.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein RCC1 PF00415.18 EFC46741.1 - 1.8e-31 108.5 2.9 5.7e-07 30.0 0.0 7.6 6 2 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46741.1 - 2.1e-28 97.5 9.6 1.2e-08 34.6 0.0 6.2 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Crust_neurohorm PF01147.17 EFC46742.1 - 0.0039 17.0 0.6 0.0075 16.1 0.6 1.6 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family TIG PF01833.24 EFC46743.1 - 3.7e-06 26.9 1.5 6.5e-06 26.1 0.2 2.2 2 0 0 2 2 2 1 IPT/TIG domain DUF4116 PF13475.6 EFC46744.1 - 4.3e-77 253.7 10.9 1.8e-14 53.2 0.0 8.4 7 1 1 8 8 8 8 Domain of unknown function (DUF4116) NTase_sub_bind PF08780.11 EFC46744.1 - 0.077 13.0 0.9 0.33 10.9 0.1 2.5 4 0 0 4 4 4 0 Nucleotidyltransferase substrate binding protein like YkuD_2 PF13645.6 EFC46744.1 - 0.093 12.2 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 L,D-transpeptidase catalytic domain TCTP PF00838.17 EFC46745.1 - 4.7e-19 69.3 0.1 6.1e-19 69.0 0.1 1.2 1 0 0 1 1 1 1 Translationally controlled tumour protein Peptidase_M54 PF07998.11 EFC46745.1 - 0.0016 18.5 0.4 0.0022 18.0 0.4 1.1 1 0 0 1 1 1 1 Peptidase family M54 ATP-synt_A PF00119.20 EFC46745.1 - 0.12 12.3 0.2 0.15 12.0 0.2 1.1 1 0 0 1 1 1 0 ATP synthase A chain HATPase_c PF02518.26 EFC46746.1 - 2.7e-19 69.7 0.1 4.8e-19 68.9 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC46746.1 - 6.3e-16 58.5 0.2 1.2e-15 57.6 0.2 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC46746.1 - 7.5e-10 38.7 1.0 1.8e-09 37.5 0.0 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EFC46746.1 - 0.014 15.3 0.2 0.043 13.7 0.2 1.9 1 1 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 EFC46746.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NO_synthase PF02898.15 EFC46747.1 - 2.1e-145 484.3 0.5 2.5e-145 484.1 0.5 1.0 1 0 0 1 1 1 1 Nitric oxide synthase, oxygenase domain DB_JBP1 PF18526.1 EFC46747.1 - 0.0085 16.0 0.9 0.077 12.9 0.1 2.2 2 0 0 2 2 2 1 Thymine dioxygenase JBP1 DNA-binding domain Pro_isomerase PF00160.21 EFC46748.1 - 1.2e-34 119.8 0.0 1.4e-34 119.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD VHP PF02209.19 EFC46749.1 - 4.5e-11 42.6 4.1 1.3e-10 41.1 4.1 1.9 1 0 0 1 1 1 1 Villin headpiece domain SHOCT PF09851.9 EFC46749.1 - 1.4e-05 24.7 0.4 1.4e-05 24.7 0.4 3.0 3 0 0 3 3 3 1 Short C-terminal domain GvpG PF05120.12 EFC46749.1 - 2.3e-05 24.3 12.3 4.9e-05 23.2 5.5 2.9 3 0 0 3 3 3 2 Gas vesicle protein G PPR_2 PF13041.6 EFC46752.1 - 6.7e-68 224.7 15.4 3.5e-11 43.1 0.0 14.8 10 4 6 16 16 16 10 PPR repeat family PPR PF01535.20 EFC46752.1 - 2.2e-67 218.7 15.6 0.00077 19.6 0.0 18.6 19 0 0 19 19 18 15 PPR repeat DYW_deaminase PF14432.6 EFC46752.1 - 3.3e-37 127.2 0.3 7.9e-37 126.0 0.3 1.7 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases PPR_3 PF13812.6 EFC46752.1 - 6.6e-30 103.0 16.1 1.1e-06 28.6 0.0 11.8 10 2 4 14 14 14 7 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC46752.1 - 1e-28 98.7 14.6 0.13 12.0 0.0 16.4 18 1 0 18 18 18 6 PPR repeat PPR_long PF17177.4 EFC46752.1 - 2.7e-19 69.4 13.8 3.2e-08 33.2 0.3 6.1 2 1 4 7 7 7 4 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 EFC46752.1 - 3.4e-09 36.7 0.0 65 4.7 0.0 10.3 10 1 2 12 12 10 0 Tetratricopeptide repeat Clathrin PF00637.20 EFC46752.1 - 1.7e-07 31.2 17.9 0.67 9.8 0.1 7.7 3 2 4 7 7 7 3 Region in Clathrin and VPS TPR_19 PF14559.6 EFC46752.1 - 2.7e-07 31.0 4.2 1.3 9.6 0.2 8.2 8 2 2 10 10 10 1 Tetratricopeptide repeat RPN7 PF10602.9 EFC46752.1 - 3.6e-06 26.8 3.0 21 4.8 0.0 6.7 7 0 0 7 7 7 0 26S proteasome subunit RPN7 Vps39_1 PF10366.9 EFC46752.1 - 2.6e-05 24.5 7.6 2.7 8.3 0.3 5.6 5 0 0 5 5 5 1 Vacuolar sorting protein 39 domain 1 TPR_16 PF13432.6 EFC46752.1 - 0.0018 18.9 0.1 0.83 10.4 0.0 4.3 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46752.1 - 0.0024 17.9 0.0 6.3 7.3 0.0 4.6 5 0 0 5 5 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC46752.1 - 0.0098 15.7 1.0 80 3.3 0.1 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC46752.1 - 0.017 15.7 1.5 1.4e+02 3.5 0.0 7.1 10 0 0 10 10 7 0 Tetratricopeptide repeat ERAP1_C PF11838.8 EFC46752.1 - 0.082 12.4 0.5 1.2 8.6 0.0 2.7 2 1 1 3 3 3 0 ERAP1-like C-terminal domain ANAPC3 PF12895.7 EFC46752.1 - 0.088 13.0 5.8 18 5.6 0.1 4.9 6 0 0 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 EF-hand_2 PF09068.11 EFC46752.1 - 0.15 12.2 6.5 34 4.6 0.1 4.5 4 0 0 4 4 4 0 EF hand VAPB_antitox PF02697.14 EFC46752.1 - 0.23 12.3 10.7 3.6 8.4 0.8 4.7 5 0 0 5 5 4 0 Putative antitoxin MNE1 PF13762.6 EFC46752.1 - 0.71 9.9 6.0 67 3.4 0.0 4.6 3 1 1 4 4 4 0 Mitochondrial splicing apparatus component TPR_2 PF07719.17 EFC46752.1 - 0.99 9.7 8.4 92 3.5 0.3 6.3 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46752.1 - 1.1 9.2 3.0 74 3.4 0.2 4.6 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF5426 PF17473.2 EFC46752.1 - 1.4 9.2 7.6 0.29 11.4 0.8 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5426) HSCB_C PF07743.13 EFC46752.1 - 1.8 9.1 5.2 25 5.5 0.2 3.3 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Rpn9_C PF18261.1 EFC46752.1 - 2.7 7.7 6.9 0.78 9.4 0.2 3.1 4 0 0 4 4 3 0 Rpn9 C-terminal helix Exog_C PF18026.1 EFC46752.1 - 6.2 7.0 6.7 31 4.7 0.0 5.0 7 0 0 7 7 5 0 Endo/exonuclease (EXOG) C-terminal domain DUF2989 PF11207.8 EFC46752.1 - 6.2 6.5 10.2 0.89 9.3 0.5 3.8 3 1 2 5 5 4 0 Protein of unknown function (DUF2989) DUF4116 PF13475.6 EFC46753.1 - 1.7e-56 187.8 39.7 1.1e-08 34.6 0.2 12.3 4 4 8 12 12 12 12 Domain of unknown function (DUF4116) La PF05383.17 EFC46753.1 - 0.076 13.1 0.2 1.1 9.3 0.0 3.1 3 0 0 3 3 3 0 La domain F-box-like PF12937.7 EFC46754.1 - 9.4e-09 35.0 0.1 1.8e-08 34.1 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC46754.1 - 0.00037 20.3 0.0 0.0011 18.8 0.0 1.8 1 0 0 1 1 1 1 F-box domain Ank_4 PF13637.6 EFC46754.1 - 0.0028 18.2 0.0 0.0097 16.5 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) SAM_MT PF04445.13 EFC46754.1 - 0.067 12.6 0.2 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 Putative SAM-dependent methyltransferase Ank_2 PF12796.7 EFC46754.1 - 0.071 13.7 0.0 0.57 10.8 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) CAF1 PF04857.20 EFC46754.1 - 0.098 11.8 1.1 6 5.9 0.0 3.1 1 1 2 3 3 3 0 CAF1 family ribonuclease DRMBL PF07522.14 EFC46756.1 - 3.1e-05 24.1 0.2 8e-05 22.8 0.2 1.7 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EFC46756.1 - 0.1 12.1 0.1 0.2 11.1 0.1 1.6 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Actin PF00022.19 EFC46757.1 - 1e-56 192.3 0.0 2.6e-56 191.0 0.0 1.8 1 1 0 1 1 1 1 Actin Aminotran_1_2 PF00155.21 EFC46758.1 - 2.6e-58 198.0 0.0 3.3e-58 197.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EFC46758.1 - 3e-07 30.1 0.0 4.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 EFC46758.1 - 2.3e-06 26.8 0.0 3.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EFC46758.1 - 1.1e-05 24.4 0.0 1.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 EFC46758.1 - 0.00031 19.4 0.0 0.00054 18.6 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Pkinase_Tyr PF07714.17 EFC46759.1 - 1.3e-34 119.7 0.0 1.4e-34 119.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC46759.1 - 1.2e-33 116.6 0.0 1.4e-33 116.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 EFC46759.1 - 0.0018 17.3 0.0 0.0024 16.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC46759.1 - 0.0021 18.0 0.0 0.0026 17.7 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 EFC46759.1 - 0.11 11.6 0.0 4.5 6.4 0.0 2.1 1 1 1 2 2 2 0 Fructosamine kinase PHM7_cyt PF14703.6 EFC46760.1 - 3e-28 99.2 0.0 9.1e-28 97.7 0.0 1.9 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 EFC46760.1 - 7.6e-12 45.1 13.5 3.3e-11 43.0 13.5 2.1 1 1 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 EFC46760.1 - 6.7e-09 35.7 0.7 6.7e-09 35.7 0.7 2.9 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport RRM_1 PF00076.22 EFC46760.1 - 0.00081 19.2 0.0 0.0024 17.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2512 PF10710.9 EFC46760.1 - 0.1 12.3 8.1 0.43 10.2 8.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) DUF2706 PF10913.8 EFC46760.1 - 2.2 8.2 4.9 11 5.9 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2706) CholecysA-Rec_N PF09193.10 EFC46761.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Cholecystokinin A receptor, N-terminal F-box-like PF12937.7 EFC46763.1 - 1.2e-05 25.1 0.1 2.8e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC46763.1 - 3.4e-05 23.6 1.4 6.6e-05 22.7 0.3 2.1 2 0 0 2 2 2 1 F-box domain Collagen PF01391.18 EFC46764.1 - 3.3e-05 23.6 9.3 3.3e-05 23.6 9.3 5.1 4 1 0 4 4 4 2 Collagen triple helix repeat (20 copies) KTI12 PF08433.10 EFC46764.1 - 0.032 13.7 0.1 0.058 12.8 0.1 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 COX14 PF14880.6 EFC46765.1 - 0.16 11.8 0.7 0.47 10.3 0.1 2.1 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF4116 PF13475.6 EFC46766.1 - 8.3e-147 476.9 29.1 3.1e-18 65.2 0.1 10.2 3 2 6 11 11 11 10 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC46766.1 - 5.2e-24 85.0 3.5 5.2e-24 85.0 3.5 3.5 3 1 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46766.1 - 4.6e-09 35.9 0.5 8.1e-08 31.9 0.1 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase AfsA PF03756.13 EFC46766.1 - 0.00013 22.0 0.0 1.9 8.5 0.0 4.0 1 1 2 4 4 4 1 A-factor biosynthesis hotdog domain UPF0552 PF10574.9 EFC46766.1 - 0.00038 19.9 4.7 1 8.7 0.1 3.9 2 1 2 4 4 4 2 Arp2/3-interacting proteins Arpin DUF5334 PF17268.2 EFC46766.1 - 0.0015 18.8 0.1 0.98 9.8 0.0 4.3 2 1 2 4 4 4 1 Family of unknown function (DUF5334) NAD_binding_11 PF14833.6 EFC46766.1 - 0.0027 18.0 2.3 1.9 8.7 0.0 5.0 2 1 2 5 5 5 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF2853 PF11015.8 EFC46766.1 - 0.82 10.4 14.4 5.8 7.6 0.5 5.7 2 2 3 5 5 5 0 Protein of unknown function (DUF2853) Ras PF00071.22 EFC46767.1 - 1.1e-18 67.4 0.2 4.8e-05 23.0 0.1 3.3 3 0 0 3 3 3 3 Ras family Roc PF08477.13 EFC46767.1 - 2.7e-05 24.3 0.0 0.0053 17.0 0.0 3.0 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC46767.1 - 0.0089 15.6 0.9 2 7.9 0.0 2.7 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC46767.1 - 0.035 14.2 0.5 14 5.8 0.1 3.1 2 1 1 3 3 3 0 50S ribosome-binding GTPase PAP1 PF08601.10 EFC46767.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.6 2 1 1 3 3 3 0 Transcription factor PAP1 FAD_binding_2 PF00890.24 EFC46768.1 - 3.2e-63 214.3 0.0 1.6e-62 211.9 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFC46768.1 - 1.1e-06 28.7 0.0 4.1e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC46768.1 - 4.1e-06 26.6 0.1 2.6e-05 24.0 0.1 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Abhydrolase_6 PF12697.7 EFC46768.1 - 8.6e-06 26.5 0.0 8.1e-05 23.3 0.0 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family Pyr_redox_2 PF07992.14 EFC46768.1 - 1.8e-05 24.2 0.3 0.0082 15.4 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_1 PF00561.20 EFC46768.1 - 1.9e-05 24.5 0.0 8.4e-05 22.3 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold FAD_oxidored PF12831.7 EFC46768.1 - 2.9e-05 23.6 0.0 5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFC46768.1 - 0.00017 20.9 0.2 0.16 11.1 0.0 3.3 3 0 0 3 3 3 1 Thi4 family HI0933_like PF03486.14 EFC46768.1 - 0.0011 17.8 0.1 0.014 14.1 0.0 2.3 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 EFC46768.1 - 0.0068 15.5 0.7 1.6 7.7 0.0 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A DUF4116 PF13475.6 EFC46769.1 - 5.2e-125 407.1 15.5 1.9e-18 65.9 0.1 7.2 3 1 5 8 8 8 8 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC46769.1 - 5.6e-24 84.9 7.8 1.1e-23 83.9 3.3 3.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46769.1 - 1.3e-08 34.5 0.1 2.8e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase NAD_binding_11 PF14833.6 EFC46769.1 - 0.017 15.4 0.9 14 5.9 0.0 3.9 1 1 3 4 4 4 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Lectin_N PF03954.14 EFC46769.1 - 0.086 12.6 4.1 0.14 11.9 1.6 2.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DivIC PF04977.15 EFC46769.1 - 9.2 6.1 10.4 0.86 9.4 1.5 3.8 3 0 0 3 3 3 0 Septum formation initiator LRR_8 PF13855.6 EFC46770.1 - 3.9e-22 77.8 43.3 1.7e-07 30.9 3.1 5.8 2 1 5 7 7 7 7 Leucine rich repeat LRR_6 PF13516.6 EFC46770.1 - 1.6e-16 58.9 39.9 0.0001 22.0 0.1 10.8 12 0 0 12 12 12 6 Leucine Rich repeat LRR_4 PF12799.7 EFC46770.1 - 4.2e-16 58.8 53.8 0.00046 20.5 1.7 7.7 3 3 4 8 8 8 8 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 EFC46770.1 - 3.2e-06 27.6 7.9 11 6.8 0.1 7.3 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC46770.1 - 7.8e-06 25.5 12.4 0.00044 19.8 1.6 3.8 1 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EFC46770.1 - 0.0068 16.8 49.6 4.4 8.2 1.7 11.1 11 1 0 11 11 11 3 Leucine Rich Repeat GFO_IDH_MocA PF01408.22 EFC46771.1 - 9.5e-18 65.2 0.1 1.8e-17 64.3 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold KASH_CCD PF14662.6 EFC46772.1 - 0.00016 21.6 23.8 0.00016 21.6 23.8 4.5 3 1 2 5 5 5 1 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 EFC46772.1 - 0.0045 17.1 10.3 0.0045 17.1 10.3 4.7 3 1 2 5 5 5 1 Afadin- and alpha -actinin-Binding PheRS_DBD1 PF18552.1 EFC46772.1 - 0.3 10.9 0.1 0.3 10.9 0.1 3.2 4 0 0 4 4 4 0 PheRS DNA binding domain 1 Sterile PF03015.19 EFC46772.1 - 0.36 11.1 0.0 0.36 11.1 0.0 2.9 4 0 0 4 4 4 0 Male sterility protein SlyX PF04102.12 EFC46772.1 - 0.84 10.3 34.8 0.15 12.7 4.6 5.6 2 2 2 4 4 4 0 SlyX Peroxidase_2 PF01328.17 EFC46772.1 - 3.4 8.1 5.3 1 9.9 1.1 2.3 2 0 0 2 2 2 0 Peroxidase, family 2 Ras PF00071.22 EFC46773.1 - 1.3e-06 28.1 0.1 3.5e-05 23.5 0.1 2.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC46773.1 - 0.00016 21.9 0.0 0.00055 20.1 0.0 2.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC46773.1 - 0.00049 19.7 0.0 0.11 12.0 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 EFC46773.1 - 0.0011 18.4 0.0 0.003 16.9 0.0 1.9 1 0 0 1 1 1 1 AIG1 family Arf PF00025.21 EFC46773.1 - 0.0043 16.5 0.1 0.016 14.7 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC46773.1 - 0.01 15.9 0.1 0.083 13.0 0.0 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC46773.1 - 0.033 14.1 7.9 1.1 9.1 0.1 3.4 3 1 1 4 4 4 0 RsgA GTPase AAA_33 PF13671.6 EFC46773.1 - 0.1 12.8 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain F-box-like PF12937.7 EFC46773.1 - 0.18 11.7 0.6 1.7 8.6 0.2 2.5 2 0 0 2 2 2 0 F-box-like SMN PF06003.12 EFC46773.1 - 1.5 8.0 5.0 2.4 7.3 5.0 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) G-alpha PF00503.20 EFC46774.1 - 1.7e-43 149.1 18.7 1.2e-41 143.1 18.7 2.1 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC46774.1 - 2.4e-05 23.8 0.2 0.1 12.0 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC46774.1 - 0.00019 20.9 1.2 0.044 13.1 0.1 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 EFC46774.1 - 0.0013 19.0 0.0 0.0065 16.8 0.0 2.2 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 EFC46774.1 - 0.0044 17.2 0.3 0.014 15.6 0.1 2.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC46774.1 - 0.006 16.6 0.0 1 9.4 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Sigma54_activat PF00158.26 EFC46774.1 - 0.0063 16.2 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain ABC_tran PF00005.27 EFC46774.1 - 0.0093 16.5 2.0 0.016 15.7 1.5 1.9 2 1 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 EFC46774.1 - 0.0094 15.5 0.6 0.026 14.1 0.6 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region TniB PF05621.11 EFC46774.1 - 0.036 13.5 0.1 0.069 12.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial TniB protein DUF2779 PF11074.8 EFC46774.1 - 0.66 10.4 5.1 0.8 10.2 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function(DUF2779) G-alpha PF00503.20 EFC46775.1 - 1.3e-09 37.7 0.4 1.4e-09 37.6 0.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Pkinase PF00069.25 EFC46776.1 - 1.4e-53 182.0 1.7 2e-53 181.4 1.7 1.3 1 0 0 1 1 1 1 Protein kinase domain NHL PF01436.21 EFC46776.1 - 3.1e-39 131.1 3.5 5.8e-06 26.1 0.0 11.2 12 0 0 12 12 12 6 NHL repeat Pkinase_Tyr PF07714.17 EFC46776.1 - 9.9e-33 113.5 0.3 1.5e-32 112.9 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SGL PF08450.12 EFC46776.1 - 4.8e-09 36.2 4.7 0.02 14.5 0.0 7.3 4 2 3 7 7 7 2 SMP-30/Gluconolactonase/LRE-like region TMEM154 PF15102.6 EFC46776.1 - 1.9e-05 24.6 0.0 4.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 TMEM154 protein family EGF_2 PF07974.13 EFC46776.1 - 2.6e-05 24.5 23.2 0.00021 21.6 6.7 2.6 2 0 0 2 2 2 2 EGF-like domain Arylesterase PF01731.20 EFC46776.1 - 0.0003 20.9 9.8 0.12 12.6 0.0 6.8 7 0 0 7 7 7 1 Arylesterase Pkinase_fungal PF17667.1 EFC46776.1 - 0.00038 19.4 0.1 0.00061 18.7 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Shisa PF13908.6 EFC46776.1 - 0.002 18.4 0.3 0.0035 17.6 0.3 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Str_synth PF03088.16 EFC46776.1 - 0.0087 16.2 1.0 7.9 6.7 0.0 5.8 6 0 0 6 6 6 1 Strictosidine synthase ODV-E18 PF10717.9 EFC46776.1 - 0.027 14.3 0.4 0.078 12.9 0.4 1.7 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Protocadherin PF08374.11 EFC46776.1 - 0.04 13.9 0.0 0.081 12.9 0.0 1.4 1 0 0 1 1 1 0 Protocadherin EphA2_TM PF14575.6 EFC46776.1 - 0.078 13.9 0.0 0.17 12.8 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3377 PF11857.8 EFC46776.1 - 0.11 12.5 5.5 0.052 13.5 3.0 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF3377) ECSCR PF15820.5 EFC46776.1 - 0.13 12.1 2.0 0.36 10.7 2.0 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Kdo PF06293.14 EFC46776.1 - 0.17 11.2 0.2 0.3 10.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Insulin_TMD PF17870.1 EFC46776.1 - 0.21 11.7 9.7 0.84 9.8 9.7 2.1 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Ldl_recept_b PF00058.17 EFC46776.1 - 0.43 11.1 2.3 49 4.5 0.0 4.8 5 1 0 5 5 4 0 Low-density lipoprotein receptor repeat class B DUF5385 PF17359.2 EFC46776.1 - 1.7 8.2 4.3 4 6.9 4.3 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5385) Sec62 PF03839.16 EFC46779.1 - 0.76 9.3 6.3 1.1 8.8 6.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Cyc-maltodext_C PF10438.9 EFC46780.1 - 0.44 10.7 4.6 1.8 8.7 3.5 2.4 1 1 1 2 2 2 0 Cyclo-malto-dextrinase C-terminal domain TRAM_LAG1_CLN8 PF03798.16 EFC46781.1 - 1.4e-23 83.7 27.4 1.4e-23 83.7 27.4 1.5 2 0 0 2 2 2 1 TLC domain Pkinase PF00069.25 EFC46782.1 - 2.7e-62 210.5 0.1 2.7e-61 207.3 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46782.1 - 7.9e-31 107.3 0.4 3.5e-23 82.2 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC46782.1 - 6.3e-07 28.7 0.6 8.7e-07 28.2 0.6 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC46782.1 - 0.00015 21.2 0.0 0.00031 20.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC46782.1 - 0.00016 21.1 0.3 0.0029 17.0 0.0 2.6 3 0 0 3 3 3 1 Kinase-like Pox_ser-thr_kin PF05445.11 EFC46782.1 - 0.0062 15.6 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Pkinase_C PF00433.24 EFC46782.1 - 0.0095 16.6 0.9 0.027 15.2 0.9 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain RIO1 PF01163.22 EFC46782.1 - 0.029 14.0 0.6 0.33 10.5 0.0 2.3 1 1 1 2 2 2 0 RIO1 family APH PF01636.23 EFC46782.1 - 0.044 13.7 0.1 0.064 13.2 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC46782.1 - 0.049 12.7 0.0 0.087 11.9 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 DUF1884 PF08967.10 EFC46783.1 - 0.067 13.4 0.1 0.54 10.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1884) SRP_TPR_like PF17004.5 EFC46783.1 - 1.8 8.6 4.6 1.2 9.2 0.3 3.0 3 0 0 3 3 3 0 Putative TPR-like repeat YdjM PF04307.14 EFC46784.1 - 0.19 11.0 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase ORF6N PF10543.9 EFC46784.1 - 1.2 9.4 5.1 1.1 9.5 0.8 2.8 3 0 0 3 3 3 0 ORF6N domain Ank_2 PF12796.7 EFC46785.1 - 2.1e-11 44.2 0.4 0.00022 21.7 0.1 3.4 3 1 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC46785.1 - 5.1e-09 35.6 3.5 0.002 18.5 0.1 5.1 6 0 0 6 6 6 2 Ankyrin repeat BTB PF00651.31 EFC46785.1 - 1.1e-08 35.3 0.2 3e-08 33.9 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain Ank_5 PF13857.6 EFC46785.1 - 2.4e-06 27.7 0.3 0.0099 16.2 0.2 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC46785.1 - 6.9e-06 26.3 2.4 1.9 9.1 0.0 6.3 7 1 0 7 7 7 2 Ankyrin repeat Ank_4 PF13637.6 EFC46785.1 - 0.0036 17.9 0.1 0.6 10.8 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Mnd1 PF03962.15 EFC46785.1 - 0.0065 16.7 0.2 0.045 14.0 0.2 2.5 1 0 0 1 1 1 1 Mnd1 HTH domain FAP206 PF12018.8 EFC46785.1 - 0.017 14.7 0.9 0.054 13.0 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function Pkinase_Tyr PF07714.17 EFC46786.1 - 3.9e-41 141.1 0.0 4.5e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC46786.1 - 2.3e-31 109.1 0.1 3.3e-31 108.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 EFC46786.1 - 1.1e-05 24.9 0.8 1.6e-05 24.4 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC46786.1 - 1.9e-05 23.6 0.1 2.8e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC46786.1 - 0.17 11.8 0.0 11 5.8 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Phospholip_A2_1 PF00068.19 EFC46787.1 - 0.042 14.3 0.1 0.094 13.2 0.1 1.5 1 0 0 1 1 1 0 Phospholipase A2 RCC1_2 PF13540.6 EFC46788.1 - 4.1e-28 96.6 22.7 8.2e-06 25.5 0.1 9.5 9 0 0 9 9 9 7 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC46788.1 - 2.9e-17 63.0 7.5 0.28 11.9 0.0 10.1 10 0 0 10 10 10 5 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC46788.1 - 1.2e-10 41.5 52.4 1.3e-05 25.4 8.1 4.4 4 0 0 4 4 4 3 EGF-like domain Y_phosphatase PF00102.27 EFC46789.1 - 4.6e-20 72.2 0.4 4.9e-20 72.1 0.4 1.0 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFC46789.1 - 0.00096 19.0 2.5 0.0019 18.0 2.5 1.7 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFC46789.1 - 0.0056 16.7 1.7 0.0064 16.5 1.6 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family HECA PF15353.6 EFC46789.1 - 0.059 13.6 0.1 0.066 13.5 0.1 1.0 1 0 0 1 1 1 0 Headcase protein family homologue PTPlike_phytase PF14566.6 EFC46789.1 - 0.7 10.0 2.9 0.52 10.4 1.1 1.7 1 1 1 2 2 2 0 Inositol hexakisphosphate LRR_6 PF13516.6 EFC46790.1 - 2.9e-24 83.0 16.5 9.1e-05 22.2 0.2 9.8 10 0 0 10 10 10 7 Leucine Rich repeat LRR_8 PF13855.6 EFC46790.1 - 2.8e-19 68.6 11.5 2.5e-06 27.1 0.2 5.4 3 2 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC46790.1 - 5.6e-17 61.6 16.9 0.00026 21.3 0.5 7.2 2 1 8 10 10 10 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46790.1 - 5.1e-07 29.4 8.3 49 5.1 0.0 8.3 8 2 0 8 8 8 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC46790.1 - 3.6e-06 26.6 1.8 0.0032 17.0 0.1 2.7 1 1 1 3 3 3 3 Leucine-rich repeat Pox_A6 PF04924.12 EFC46790.1 - 0.13 11.2 0.9 0.25 10.3 0.2 1.7 2 0 0 2 2 2 0 Poxvirus A6 protein Guanylate_cyc PF00211.20 EFC46793.1 - 0.0041 16.8 0.5 0.016 14.9 0.2 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PH_5 PF15405.6 EFC46793.1 - 0.0087 16.2 0.5 0.022 14.8 0.5 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Lebercilin PF15619.6 EFC46794.1 - 0.16 11.6 0.5 0.22 11.1 0.5 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF2157 PF09925.9 EFC46794.1 - 0.33 10.8 3.0 43 3.9 0.1 3.9 5 0 0 5 5 5 0 Predicted membrane protein (DUF2157) Laminin_EGF PF00053.24 EFC46794.1 - 1.3 9.2 108.3 1.4 9.1 13.2 7.0 2 1 5 7 7 7 0 Laminin EGF domain CRT-like PF08627.10 EFC46799.1 - 5.5e-28 97.9 26.0 8e-25 87.5 18.0 3.7 2 1 1 3 3 3 2 CRT-like, chloroquine-resistance transporter-like Vps55 PF04133.14 EFC46799.1 - 0.015 15.2 1.1 0.015 15.2 1.1 2.8 2 2 0 2 2 2 0 Vacuolar protein sorting 55 EFP_N PF08207.12 EFC46800.1 - 0.0037 17.3 0.0 0.0074 16.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain LRR_6 PF13516.6 EFC46802.1 - 4.3e-39 129.2 15.7 0.0015 18.4 0.0 12.7 14 0 0 14 14 14 10 Leucine Rich repeat LRR_8 PF13855.6 EFC46802.1 - 5.3e-32 109.4 13.4 3.7e-12 45.8 1.4 5.9 5 1 1 6 6 6 5 Leucine rich repeat LRR_4 PF12799.7 EFC46802.1 - 1.4e-25 89.0 20.7 0.00018 21.8 1.8 8.6 3 2 5 9 9 9 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC46802.1 - 8.4e-08 31.7 8.3 29 5.7 0.1 10.1 10 2 0 10 10 10 0 Leucine Rich Repeat LRR_9 PF14580.6 EFC46802.1 - 1.6e-06 27.7 10.1 0.0016 18.0 1.0 4.4 1 1 3 5 5 5 4 Leucine-rich repeat DUF1815 PF08844.10 EFC46802.1 - 0.081 12.9 1.0 19 5.3 0.3 4.7 3 1 0 4 4 4 0 Domain of unknown function (DUF1815) XS PF03468.14 EFC46802.1 - 0.15 12.4 0.0 0.42 10.9 0.0 1.7 1 0 0 1 1 1 0 XS domain DIRP PF06584.13 EFC46802.1 - 0.16 12.2 0.0 0.34 11.1 0.0 1.6 1 0 0 1 1 1 0 DIRP EGF_2 PF07974.13 EFC46803.1 - 2.1e-47 159.2 302.4 0.00059 20.2 6.7 17.8 17 0 0 17 17 17 16 EGF-like domain RGS PF00615.19 EFC46803.1 - 7.5e-09 35.9 2.4 1.8e-08 34.7 2.2 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain B_lectin PF01453.24 EFC46803.1 - 0.0052 17.3 0.8 2 9.0 0.1 3.3 2 1 2 4 4 4 3 D-mannose binding lectin MORN PF02493.20 EFC46803.1 - 0.012 15.5 11.2 68 3.7 0.0 9.2 10 0 0 10 10 10 0 MORN repeat FA_desaturase PF00487.24 EFC46803.1 - 2.9 7.6 5.2 3.6 7.3 3.1 2.1 2 0 0 2 2 2 0 Fatty acid desaturase EcKinase PF02958.20 EFC46804.1 - 1.3e-10 41.1 0.2 2.8e-09 36.7 0.1 2.2 2 0 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 EFC46804.1 - 3.9e-10 39.2 0.4 4.8e-09 35.6 0.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.23 EFC46804.1 - 3.5e-08 33.7 0.0 3.3e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC46804.1 - 0.0029 17.2 0.2 0.0074 15.9 0.1 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase DUF2187 PF09953.9 EFC46804.1 - 0.014 15.3 0.1 0.059 13.4 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) DUF1642 PF07852.11 EFC46804.1 - 0.036 14.7 0.0 0.1 13.2 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1642) DUF3097 PF11296.8 EFC46804.1 - 0.062 12.5 0.0 0.098 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) LBP_BPI_CETP_C PF02886.17 EFC46805.1 - 3.8e-18 65.8 3.6 1.2e-17 64.2 3.1 2.1 2 0 0 2 2 2 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EFC46805.1 - 0.0071 16.0 4.4 0.022 14.4 0.3 2.5 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain Palm_thioest PF02089.15 EFC46806.1 - 1.4e-78 264.1 0.0 2.4e-78 263.3 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 EFC46806.1 - 0.00075 18.9 0.1 0.0018 17.6 0.1 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) TPR_2 PF07719.17 EFC46807.1 - 5.1e-05 23.1 9.8 0.011 15.8 0.1 5.0 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46807.1 - 0.0013 18.5 14.2 0.22 11.4 0.1 5.2 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46807.1 - 0.0028 17.9 0.5 0.0028 17.9 0.5 3.4 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC46807.1 - 0.041 14.5 3.3 1.1 10.1 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46807.1 - 1.1 9.6 11.4 2.1 8.8 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat RGS PF00615.19 EFC46809.1 - 0.0054 17.0 8.4 0.0054 17.0 8.4 2.7 3 1 0 3 3 3 1 Regulator of G protein signaling domain Arc_C PF18162.1 EFC46809.1 - 0.11 12.3 0.4 0.32 10.9 0.4 1.9 1 0 0 1 1 1 0 Arc C-lobe eIF-5a PF01287.20 EFC46810.1 - 6.1e-13 48.7 0.7 8.2e-13 48.3 0.7 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 EFC46810.1 - 7.3e-06 25.9 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain CaMKII_AD PF08332.10 EFC46810.1 - 0.09 12.9 0.1 0.37 11.0 0.1 1.8 1 1 1 2 2 2 0 Calcium/calmodulin dependent protein kinase II association domain Pkinase PF00069.25 EFC46811.1 - 2.4e-31 109.1 0.0 2.6e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46811.1 - 2.4e-19 69.7 0.0 2.7e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC46811.1 - 7.5e-08 31.6 0.0 9e-08 31.3 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFC46811.1 - 9.4e-07 28.6 0.1 1.2e-06 28.3 0.1 1.1 1 0 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.11 EFC46811.1 - 0.00011 21.4 0.1 0.00012 21.2 0.1 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 EFC46811.1 - 0.00024 21.1 0.0 0.00029 20.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC46811.1 - 0.0019 17.5 0.0 0.002 17.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFC46811.1 - 0.012 15.0 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1686 PF07937.11 EFC46812.1 - 0.039 13.8 4.8 0.47 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1686) LRR_4 PF12799.7 EFC46813.1 - 1.2e-08 35.1 40.3 0.00098 19.5 5.2 8.4 5 3 5 10 10 10 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46813.1 - 0.0043 16.8 24.4 1.3 8.9 0.1 6.6 5 2 1 6 6 6 4 Leucine rich repeat DUF4332 PF14229.6 EFC46813.1 - 0.0084 16.3 0.3 0.45 10.8 0.2 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4332) F-box PF00646.33 EFC46813.1 - 0.03 14.2 2.4 0.031 14.1 0.4 2.1 2 0 0 2 2 2 0 F-box domain HHH_5 PF14520.6 EFC46813.1 - 0.12 13.0 0.0 8.5 7.1 0.0 2.6 1 1 1 2 2 2 0 Helix-hairpin-helix domain LRR_6 PF13516.6 EFC46813.1 - 1.8 8.8 19.4 2 8.7 0.4 6.9 6 0 0 6 6 6 0 Leucine Rich repeat PI-PLC-X PF00388.19 EFC46814.1 - 2.2e-66 221.9 0.1 7.1e-66 220.3 0.0 1.9 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 EFC46814.1 - 1.3e-37 128.7 0.0 2.6e-37 127.7 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 EFC46814.1 - 1.2e-12 48.0 0.0 4.2e-12 46.3 0.0 1.9 2 0 0 2 2 2 1 C2 domain Tub_N PF16322.5 EFC46814.1 - 0.013 15.9 0.6 0.022 15.2 0.6 1.3 1 0 0 1 1 1 0 Tubby N-terminal PBP1_TM PF14812.6 EFC46814.1 - 0.045 14.1 1.2 0.045 14.1 1.2 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal KIND PF16474.5 EFC46814.1 - 0.11 12.3 0.5 0.21 11.4 0.5 1.4 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain PGA2 PF07543.12 EFC46814.1 - 0.12 12.4 1.7 0.21 11.6 1.7 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF4611 PF15387.6 EFC46814.1 - 0.85 9.9 5.7 1.8 8.8 5.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 EFC46814.1 - 2.9 8.4 7.0 6.5 7.2 7.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4116 PF13475.6 EFC46815.1 - 1.3e-73 242.6 14.1 1.4e-13 50.4 0.1 8.6 7 1 0 8 8 8 8 Domain of unknown function (DUF4116) FAD_binding_3 PF01494.19 EFC46817.1 - 8e-07 28.6 0.1 0.00022 20.6 0.1 3.3 3 0 0 3 3 3 2 FAD binding domain PARP PF00644.20 EFC46818.1 - 2.7e-28 98.9 1.9 8.5e-28 97.3 1.9 1.8 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase PF00069.25 EFC46818.1 - 7.2e-11 41.9 1.7 7.2e-11 41.9 1.7 2.6 2 1 1 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46818.1 - 7.2e-10 38.6 0.3 1.5e-09 37.5 0.3 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase FAM184 PF15665.5 EFC46819.1 - 0.0022 17.8 16.3 0.0022 17.8 16.3 4.1 1 1 1 3 3 3 2 Family with sequence similarity 184, A and B APG6_N PF17675.1 EFC46819.1 - 0.0039 17.7 28.8 0.0039 17.7 28.8 3.6 1 1 2 3 3 3 1 Apg6 coiled-coil region DUF3584 PF12128.8 EFC46819.1 - 0.0049 14.5 54.5 0.0079 13.8 54.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF1664 PF07889.12 EFC46819.1 - 0.017 15.2 8.1 0.017 15.2 8.1 5.5 2 1 3 5 5 4 0 Protein of unknown function (DUF1664) TetR_C_22 PF17928.1 EFC46819.1 - 0.055 13.8 0.0 21 5.5 0.0 3.0 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Spc7 PF08317.11 EFC46819.1 - 0.26 10.1 71.2 0.0069 15.3 26.6 3.7 1 1 2 3 3 3 0 Spc7 kinetochore protein MscS_porin PF12795.7 EFC46819.1 - 0.36 10.3 62.6 0.043 13.4 22.3 3.3 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain IFT57 PF10498.9 EFC46819.1 - 1.2 8.1 60.9 0.33 9.9 11.7 3.9 3 1 1 4 4 4 0 Intra-flagellar transport protein 57 ERM PF00769.19 EFC46819.1 - 1.7 8.4 67.8 2.7 7.7 25.8 2.6 1 1 2 3 3 3 0 Ezrin/radixin/moesin family GAS PF13851.6 EFC46819.1 - 3.7 6.9 76.8 0.81 9.0 30.6 4.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Filament PF00038.21 EFC46819.1 - 4.6 6.7 63.0 5.9 6.4 27.2 3.5 1 1 2 3 3 3 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 EFC46819.1 - 5.2 7.1 72.6 0.36 10.9 28.9 4.5 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein Trp_halogenase PF04820.14 EFC46820.1 - 7.7e-06 25.0 0.0 0.0025 16.7 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase FAD_oxidored PF12831.7 EFC46820.1 - 0.03 13.7 0.0 5.4 6.2 0.0 2.3 2 1 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC46820.1 - 0.046 12.9 0.1 2.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CsoS2_M PF12288.8 EFC46820.1 - 0.12 11.7 0.7 0.18 11.2 0.7 1.1 1 0 0 1 1 1 0 Carboxysome shell peptide mid-region Sel1 PF08238.12 EFC46821.1 - 9.7e-09 35.6 13.8 0.0013 19.4 2.8 4.2 5 0 0 5 5 5 2 Sel1 repeat F-box-like PF12937.7 EFC46821.1 - 1.8e-06 27.7 2.8 6.2e-06 26.0 0.2 2.8 2 1 0 2 2 2 1 F-box-like F-box PF00646.33 EFC46821.1 - 0.096 12.6 2.0 2.6 8.0 0.6 3.3 1 1 1 2 2 2 0 F-box domain UBX PF00789.20 EFC46822.1 - 1.8e-06 28.1 2.6 3.8e-05 23.8 0.1 2.9 3 0 0 3 3 3 1 UBX domain ERM PF00769.19 EFC46822.1 - 1.7e-05 24.7 2.2 2e-05 24.6 2.2 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family ATP-synt_E PF05680.12 EFC46822.1 - 0.33 11.3 5.3 0.59 10.5 5.3 1.5 1 0 0 1 1 1 0 ATP synthase E chain LMBR1 PF04791.16 EFC46822.1 - 0.98 8.3 3.3 1 8.2 3.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Ashwin PF15323.6 EFC46823.1 - 0.18 11.8 10.6 0.21 11.6 10.6 1.1 1 0 0 1 1 1 0 Developmental protein Macoilin PF09726.9 EFC46823.1 - 1.7 7.1 11.2 1.8 7.0 11.2 1.0 1 0 0 1 1 1 0 Macoilin family Pneumovirus_M2 PF06436.11 EFC46825.1 - 0.26 10.8 3.3 3.1 7.3 0.4 3.4 2 1 0 2 2 2 0 Pneumovirus matrix protein 2 (M2) PriX PF18689.1 EFC46825.1 - 0.88 9.9 4.2 1.1 9.6 0.2 3.2 3 0 0 3 3 3 0 Primase X Frtz PF11768.8 EFC46826.1 - 2.3e-17 62.5 17.4 6.3e-10 38.0 8.4 3.8 2 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz ANAPC4_WD40 PF12894.7 EFC46826.1 - 0.04 14.2 0.0 2.7 8.3 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 EFC46827.1 - 2.8e-05 24.1 11.2 2.8e-05 24.1 11.2 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FolB PF02152.18 EFC46828.1 - 0.25 11.9 2.2 0.69 10.5 0.1 2.8 3 0 0 3 3 3 0 Dihydroneopterin aldolase Rubis-subs-bind PF09273.11 EFC46828.1 - 1.6 9.4 7.3 0.29 11.8 1.2 2.8 3 1 0 3 3 3 0 Rubisco LSMT substrate-binding ABC2_membrane_3 PF12698.7 EFC46829.1 - 0.72 8.9 15.2 1 8.4 15.2 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Na_Ca_ex PF01699.24 EFC46830.1 - 0.032 14.2 10.1 0.058 13.4 10.1 1.4 1 0 0 1 1 1 0 Sodium/calcium exchanger protein DUF2701 PF10857.8 EFC46830.1 - 0.057 13.4 0.0 0.2 11.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) EMP70 PF02990.16 EFC46830.1 - 7.1 5.2 14.9 0.65 8.6 6.0 2.0 1 1 1 2 2 2 0 Endomembrane protein 70 Macoilin PF09726.9 EFC46831.1 - 0.084 11.4 25.9 0.13 10.8 25.9 1.3 1 0 0 1 1 1 0 Macoilin family DUF1467 PF07330.12 EFC46831.1 - 0.13 12.2 1.0 0.55 10.2 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1467) PIG-P PF08510.12 EFC46832.1 - 3.1e-30 104.6 6.6 3.8e-30 104.3 6.6 1.1 1 0 0 1 1 1 1 PIG-P FRG1 PF06229.12 EFC46833.1 - 5.3e-08 32.8 0.0 5.3e-06 26.3 0.0 2.8 1 1 1 2 2 2 1 FRG1-like domain Fascin PF06268.13 EFC46833.1 - 1.3e-05 25.4 2.1 0.066 13.4 0.1 3.1 2 2 2 4 4 4 2 Fascin domain EF-hand_6 PF13405.6 EFC46833.1 - 0.0033 17.2 0.2 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 EFC46833.1 - 0.0056 16.1 0.0 0.015 14.8 0.0 1.8 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 EFC46833.1 - 0.053 13.4 0.1 0.15 11.9 0.0 1.8 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.6 EFC46833.1 - 0.061 13.8 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair TrmB PF01978.19 EFC46833.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB SBP_bac_3 PF00497.20 EFC46834.1 - 8.9e-08 31.8 0.0 1.3e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 ADP_ribosyl_GH PF03747.14 EFC46835.1 - 2.5e-34 119.3 0.0 4.3e-34 118.6 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase DUF1963 PF09234.10 EFC46836.1 - 6.8e-10 39.8 0.1 6.8e-10 39.8 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1963) F-box PF00646.33 EFC46836.1 - 0.00011 22.0 0.1 0.00032 20.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC46836.1 - 0.0022 17.9 0.0 0.0042 16.9 0.0 1.5 1 0 0 1 1 1 1 F-box-like Ank_2 PF12796.7 EFC46838.1 - 4.3e-17 62.5 2.1 4.1e-07 30.5 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC46838.1 - 8.1e-10 38.8 0.0 0.18 12.2 0.0 4.1 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC46838.1 - 1.1e-07 32.2 0.1 1.5 9.5 0.0 4.6 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC46838.1 - 1.6e-06 27.9 0.0 0.11 13.2 0.0 5.2 6 0 0 6 6 6 1 Ankyrin repeat Ank PF00023.30 EFC46838.1 - 0.00034 20.9 0.0 26 5.5 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat Ribosomal_L18 PF17135.4 EFC46839.1 - 6e-68 227.9 2.3 6.6e-68 227.8 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 EFC46839.1 - 0.0013 19.4 0.5 0.0013 19.4 0.5 1.9 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Torus PF16131.5 EFC46840.1 - 8.8e-33 113.3 3.5 8.8e-33 113.3 3.5 3.0 2 1 0 3 3 3 1 Torus domain RRM_1 PF00076.22 EFC46840.1 - 2.7e-07 30.3 0.0 5.9e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 EFC46840.1 - 0.00031 20.7 2.4 0.00083 19.3 2.4 1.8 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 EFC46840.1 - 0.017 15.0 3.0 0.036 13.9 3.0 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger Nup35_RRM_2 PF14605.6 EFC46840.1 - 0.049 13.6 0.3 0.11 12.5 0.3 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Acetyltransf_1 PF00583.25 EFC46841.1 - 0.05 13.8 0.0 0.086 13.1 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFC46841.1 - 0.054 13.6 0.0 0.87 9.7 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC46841.1 - 0.056 13.4 0.3 0.14 12.1 0.1 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain LRR_6 PF13516.6 EFC46842.1 - 8.8e-23 78.4 32.6 0.0017 18.3 0.0 13.0 14 0 0 14 14 14 7 Leucine Rich repeat LRR_4 PF12799.7 EFC46842.1 - 2.1e-13 50.2 21.9 0.014 15.8 0.2 7.5 5 1 2 8 8 8 6 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC46842.1 - 4.2e-06 26.5 0.4 2.9e-05 23.8 0.0 2.6 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 EFC46842.1 - 1.1e-05 25.3 0.0 2.5e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_8 PF13855.6 EFC46842.1 - 0.0012 18.6 17.3 0.082 12.7 0.1 6.0 4 2 2 6 6 6 3 Leucine rich repeat LRR_1 PF00560.33 EFC46842.1 - 0.016 15.7 28.3 35 5.5 0.1 10.3 9 1 0 9 9 9 0 Leucine Rich Repeat ArlS_N PF18719.1 EFC46842.1 - 0.5 10.6 7.5 9.9 6.4 0.0 3.2 2 1 1 3 3 3 0 ArlS sensor domain Ras PF00071.22 EFC46843.1 - 7e-58 194.8 0.6 8.4e-58 194.5 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46843.1 - 6.1e-37 126.5 0.3 1e-36 125.8 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46843.1 - 4.2e-17 62.1 0.2 5.2e-17 61.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC46843.1 - 2e-06 27.5 0.1 6e-06 25.9 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC46843.1 - 7.5e-06 25.5 0.3 9.5e-06 25.1 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFC46843.1 - 1.3e-05 24.7 0.1 1.9e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC46843.1 - 6.9e-05 22.9 0.1 0.00012 22.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC46843.1 - 0.00079 19.4 0.0 0.074 12.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 EFC46843.1 - 0.0052 16.3 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DLIC PF05783.11 EFC46843.1 - 0.037 12.9 0.0 0.058 12.2 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) TIR_2 PF13676.6 EFC46843.1 - 0.053 14.1 0.1 0.089 13.4 0.1 1.3 1 0 0 1 1 1 0 TIR domain TPR_12 PF13424.6 EFC46845.1 - 2.4e-11 43.8 0.6 0.0027 18.0 0.2 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC46845.1 - 0.016 15.3 0.1 12 6.2 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DHR-2 PF06920.13 EFC46845.1 - 0.019 13.6 0.4 0.045 12.4 0.4 1.6 1 1 0 1 1 1 0 Dock homology region 2 TPR_MalT PF17874.1 EFC46845.1 - 0.033 13.6 0.1 0.2 11.0 0.0 2.0 2 0 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 EFC46845.1 - 0.18 11.7 0.2 15 5.6 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat RCC1 PF00415.18 EFC46846.1 - 1.4e-25 89.7 3.7 7e-05 23.4 0.0 6.9 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC46846.1 - 3.9e-21 74.3 5.1 1.5e-06 27.8 0.1 7.0 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat IL8 PF00048.20 EFC46846.1 - 4.2 7.6 5.5 9.4 6.5 0.1 3.7 4 0 0 4 4 4 0 Small cytokines (intecrine/chemokine), interleukin-8 like Mito_carr PF00153.27 EFC46847.1 - 1.1e-60 201.5 1.9 1e-19 70.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Diphthami_syn_2 PF01902.17 EFC46848.1 - 3.7e-37 127.9 0.1 2.4e-36 125.3 0.1 1.8 1 1 0 1 1 1 1 Diphthamide synthase ThiI PF02568.14 EFC46848.1 - 0.15 11.7 0.4 1 8.9 0.0 2.4 3 0 0 3 3 3 0 Thiamine biosynthesis protein (ThiI) EVI2A PF05399.11 EFC46849.1 - 0.013 15.1 2.0 0.031 13.9 2.0 1.6 1 1 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Cation_efflux PF01545.21 EFC46849.1 - 0.017 14.9 0.2 0.021 14.6 0.2 1.1 1 0 0 1 1 1 0 Cation efflux family CD225 PF04505.12 EFC46849.1 - 0.16 12.1 0.6 20 5.4 0.1 2.3 2 0 0 2 2 2 0 Interferon-induced transmembrane protein Ank_2 PF12796.7 EFC46850.1 - 1.4e-16 60.8 0.9 4e-09 36.9 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC46850.1 - 8.1e-14 51.8 0.1 7.3e-06 26.4 0.0 4.4 3 2 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC46850.1 - 1.5e-11 43.4 0.1 0.14 12.7 0.0 6.4 6 1 1 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EFC46850.1 - 1.1e-08 35.2 0.1 0.011 16.0 0.0 3.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC46850.1 - 0.0026 18.2 0.2 9 6.9 0.1 4.4 4 1 0 4 4 4 1 Ankyrin repeat Metallophos PF00149.28 EFC46852.1 - 0.00043 20.9 0.1 0.00051 20.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC46852.1 - 0.015 15.5 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain LAX PF15681.5 EFC46852.1 - 0.026 13.4 0.4 0.038 12.8 0.4 1.3 1 1 0 1 1 1 0 Lymphocyte activation family X Hat1_N PF10394.9 EFC46853.1 - 1.7e-39 135.6 4.8 1.7e-39 135.6 4.8 3.0 4 0 0 4 4 4 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 EFC46853.1 - 0.0084 16.3 0.0 0.023 14.9 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 EFC46853.1 - 0.024 14.3 1.0 0.071 12.8 0.4 2.1 2 1 0 2 2 2 0 MOZ/SAS family Acetyltransf_7 PF13508.7 EFC46853.1 - 0.028 14.8 0.0 0.064 13.7 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC46853.1 - 0.037 14.0 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PARP_reg PF02877.14 EFC46853.1 - 0.091 12.9 0.9 0.31 11.2 0.1 2.2 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase, regulatory domain PI31_Prot_N PF11566.8 EFC46854.1 - 0.084 12.7 0.0 0.21 11.4 0.0 1.6 1 1 0 1 1 1 0 PI31 proteasome regulator N-terminal Axin_b-cat_bind PF08833.10 EFC46854.1 - 0.39 10.9 6.2 22 5.3 0.1 3.5 3 1 0 3 3 3 0 Axin beta-catenin binding domain RGS PF00615.19 EFC46855.1 - 2.1e-11 44.1 5.8 2.1e-11 44.1 5.8 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain PAS_8 PF13188.7 EFC46855.1 - 1e-05 25.4 0.0 2.9e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 EFC46855.1 - 0.014 15.6 0.1 0.044 14.0 0.1 1.9 1 0 0 1 1 1 0 PAS domain DUF996 PF06195.13 EFC46855.1 - 0.015 15.6 4.7 0.26 11.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF996) TPPK_C PF12555.8 EFC46855.1 - 0.017 15.1 4.7 0.23 11.5 0.3 2.7 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal PAS PF00989.25 EFC46855.1 - 0.021 14.8 0.0 0.051 13.6 0.0 1.6 1 0 0 1 1 1 0 PAS fold PDE4_UCR PF18100.1 EFC46855.1 - 0.15 12.7 0.2 0.15 12.7 0.2 2.6 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) RGS PF00615.19 EFC46856.1 - 0.0019 18.4 2.4 0.0052 17.0 2.4 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain PAP2_3 PF14378.6 EFC46856.1 - 0.021 14.5 3.7 1.1 8.9 0.1 2.7 2 0 0 2 2 2 0 PAP2 superfamily Methyltransf_28 PF02636.17 EFC46856.1 - 0.063 12.9 2.0 0.074 12.7 0.9 1.6 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF3514 PF12027.8 EFC46856.1 - 0.066 12.9 0.8 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3514) Ras PF00071.22 EFC46857.1 - 7.4e-46 155.7 0.6 8.1e-46 155.6 0.6 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46857.1 - 1.3e-24 86.8 0.1 1.6e-24 86.4 0.1 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46857.1 - 3.2e-12 46.3 0.1 3.6e-12 46.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC46857.1 - 9.1e-07 29.0 0.0 1.2e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC46857.1 - 4.5e-05 23.1 0.1 7.8e-05 22.3 0.1 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC46857.1 - 0.00012 21.6 0.1 0.00013 21.4 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit EGF_2 PF07974.13 EFC46858.1 - 0.0064 16.8 22.5 0.0069 16.7 6.0 4.5 5 0 0 5 5 5 2 EGF-like domain Phage_TTP_1 PF04630.12 EFC46858.1 - 0.83 8.9 5.6 0.54 9.5 1.8 2.4 2 0 0 2 2 2 0 Phage tail tube protein Ribosomal_S30 PF04758.14 EFC46859.1 - 6.9e-05 23.0 0.0 6.9e-05 23.0 0.0 2.1 2 1 0 2 2 2 1 Ribosomal protein S30 Mito_carr PF00153.27 EFC46860.1 - 2.4e-22 78.6 6.1 1e-11 44.6 0.1 3.4 3 1 0 3 3 3 2 Mitochondrial carrier protein DUF2232 PF09991.9 EFC46860.1 - 0.053 12.7 0.2 0.084 12.0 0.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) WD40 PF00400.32 EFC46861.1 - 9.5e-11 42.1 9.5 0.17 12.8 0.0 6.8 7 0 0 7 7 7 3 WD domain, G-beta repeat NPH3 PF03000.14 EFC46861.1 - 0.0018 18.0 0.0 0.0033 17.1 0.0 1.4 1 0 0 1 1 1 1 NPH3 family BACK PF07707.15 EFC46861.1 - 0.015 15.4 0.4 0.05 13.7 0.1 2.1 2 0 0 2 2 2 0 BTB And C-terminal Kelch F-box-like PF12937.7 EFC46862.1 - 0.0076 16.1 0.1 0.026 14.4 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC46862.1 - 0.086 12.8 0.0 0.32 10.9 0.0 2.0 1 0 0 1 1 1 0 F-box domain Mpv17_PMP22 PF04117.12 EFC46863.1 - 1.6e-11 44.2 0.1 4.1e-11 43.0 0.1 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family Peptidase_C97 PF05903.14 EFC46865.1 - 1.6e-37 128.7 0.0 4.1e-37 127.3 0.0 1.7 2 0 0 2 2 2 1 PPPDE putative peptidase domain PUL PF08324.11 EFC46865.1 - 1.1e-24 87.2 3.4 1.5e-24 86.7 3.4 1.1 1 0 0 1 1 1 1 PUL domain LRAT PF04970.13 EFC46865.1 - 0.052 13.9 0.1 0.17 12.2 0.1 1.8 1 0 0 1 1 1 0 Lecithin retinol acyltransferase PARG_cat PF05028.14 EFC46866.1 - 1.4e-102 343.4 2.2 2.3e-102 342.7 2.2 1.3 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF1366 PF07104.11 EFC46866.1 - 7.2 6.3 10.3 5.5 6.7 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1366) FA_desaturase PF00487.24 EFC46867.1 - 3.8e-15 56.4 41.0 1.6e-13 51.1 19.4 3.3 2 1 0 2 2 2 2 Fatty acid desaturase AtpR PF12966.7 EFC46867.1 - 0.03 14.8 6.7 0.61 10.6 0.5 2.8 2 0 0 2 2 2 0 N-ATPase, AtpR subunit DUF1240 PF06836.12 EFC46867.1 - 1.2 9.7 9.3 4.8 7.8 0.6 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1240) Pex19 PF04614.12 EFC46868.1 - 0.016 15.0 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 Pex19 protein family SNAD1 PF18744.1 EFC46868.1 - 0.1 12.5 0.6 7.8 6.3 0.2 2.3 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 1 Barstar PF01337.18 EFC46869.1 - 3.6e-13 49.3 0.2 5.7e-13 48.7 0.2 1.3 1 0 0 1 1 1 1 Barstar (barnase inhibitor) DUF749 PF05370.11 EFC46869.1 - 0.063 13.4 0.8 0.2 11.8 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF749) Oxidored-like PF09791.9 EFC46870.1 - 4.3e-06 26.3 1.4 7.3e-06 25.6 1.4 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF5522 PF17653.1 EFC46870.1 - 0.044 13.7 2.5 0.085 12.8 2.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5522) SRP-alpha_N PF04086.13 EFC46871.1 - 0.0076 16.2 5.6 0.012 15.6 5.6 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal FtsX PF02687.21 EFC46871.1 - 1.4 9.4 7.4 2.8 8.5 7.4 1.4 1 0 0 1 1 1 0 FtsX-like permease family Pox_Ag35 PF03286.14 EFC46871.1 - 3.5 7.4 10.5 0.28 10.9 4.7 2.1 1 1 1 2 2 2 0 Pox virus Ag35 surface protein TFIIA PF03153.13 EFC46871.1 - 4.7 7.1 22.1 5.9 6.8 22.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ras PF00071.22 EFC46872.1 - 3.1e-17 62.7 0.1 7.2e-17 61.4 0.1 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46872.1 - 3.1e-07 30.6 0.0 7.5e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46872.1 - 0.00011 21.8 0.1 0.0002 20.9 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_14 PF13173.6 EFC46872.1 - 0.0081 16.2 0.2 2.4 8.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 EFC46872.1 - 0.023 14.1 0.0 0.051 13.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein VirC1 PF07015.11 EFC46872.1 - 0.051 12.9 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 VirC1 protein FYVE PF01363.21 EFC46874.1 - 0.03 14.5 2.8 0.03 14.5 2.8 2.4 3 1 1 4 4 4 0 FYVE zinc finger VP_N-CPKC PF11475.8 EFC46874.1 - 5.6 7.0 6.2 6.8 6.7 1.4 2.6 2 0 0 2 2 2 0 Virion protein N terminal domain NuA4 PF09340.10 EFC46874.1 - 7.5 6.5 8.3 0.88 9.5 1.6 2.8 3 1 1 4 4 4 0 Histone acetyltransferase subunit NuA4 Pkinase PF00069.25 EFC46875.1 - 1.6e-45 155.5 0.0 2.8e-45 154.7 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46875.1 - 9.9e-40 136.4 0.0 3.4e-37 128.1 0.0 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC46875.1 - 0.0019 17.2 0.0 0.0028 16.7 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC46875.1 - 0.0074 15.1 0.0 0.0095 14.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC46875.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC46875.1 - 0.015 15.2 0.0 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 EFC46875.1 - 0.019 14.1 0.0 0.03 13.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 AbiJ_NTD4 PF18863.1 EFC46875.1 - 0.062 13.8 0.5 0.12 12.9 0.5 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 4 Pilin_GH PF16734.5 EFC46876.1 - 0.046 14.0 2.4 0.067 13.5 1.7 1.6 1 1 0 1 1 1 0 Type IV pilin-like G and H, putative NLPC_P60 PF00877.19 EFC46877.1 - 8.4e-13 48.3 0.0 1.2e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 NlpC/P60 family Peptidase_C92 PF05708.12 EFC46877.1 - 0.00026 21.1 0.1 0.041 14.0 0.0 2.3 2 0 0 2 2 2 2 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family Amidase_5 PF05382.13 EFC46877.1 - 0.0026 17.7 0.8 0.016 15.1 0.1 2.0 1 1 1 2 2 2 1 Bacteriophage peptidoglycan hydrolase C2 PF00168.30 EFC46878.1 - 4.7e-11 42.9 0.3 1.8e-10 41.0 0.3 2.1 1 0 0 1 1 1 1 C2 domain Translat_reg PF01818.17 EFC46878.1 - 0.0052 16.8 1.2 1.3 9.0 0.0 2.8 2 0 0 2 2 2 2 Bacteriophage translational regulator Orthopox_F6 PF06601.12 EFC46878.1 - 0.017 15.3 0.4 0.049 13.8 0.4 1.7 1 0 0 1 1 1 0 Orthopoxvirus F6 protein FF PF01846.19 EFC46879.1 - 0.16 12.1 0.7 1.9 8.7 0.1 2.4 2 0 0 2 2 2 0 FF domain C2 PF00168.30 EFC46881.1 - 2.5e-15 56.6 0.2 3e-15 56.4 0.2 1.0 1 0 0 1 1 1 1 C2 domain Salt_tol_Pase PF09506.10 EFC46881.1 - 0.0062 15.3 0.1 0.0062 15.3 0.1 1.1 1 0 0 1 1 1 1 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) F5_F8_type_C PF00754.25 EFC46882.1 - 7.3e-19 68.1 2.7 0.0003 20.9 0.0 6.8 8 0 0 8 8 8 5 F5/8 type C domain DDRGK PF09756.9 EFC46882.1 - 0.0064 16.1 1.3 13 5.3 0.0 4.1 4 0 0 4 4 4 3 DDRGK domain DUF4116 PF13475.6 EFC46883.1 - 2.3e-78 257.8 13.8 3.7e-17 61.8 0.0 6.9 3 2 4 7 7 7 6 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC46883.1 - 1e-23 84.0 3.1 1e-23 84.0 3.1 3.1 3 2 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46883.1 - 2.1e-08 33.8 0.1 9.6e-08 31.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase NitrOD5 PF11537.8 EFC46883.1 - 0.013 15.7 0.7 2.4 8.3 0.1 4.0 2 1 2 4 4 4 0 Nitrosopumilus output domain 5 bZIP_1 PF00170.21 EFC46883.1 - 0.016 15.3 11.0 0.067 13.3 3.2 3.4 1 1 1 2 2 2 0 bZIP transcription factor DUF5638 PF18688.1 EFC46883.1 - 0.024 14.9 2.2 0.024 14.9 2.2 5.6 8 0 0 8 8 8 0 Family of unknown function (DUF5638) TSC22 PF01166.18 EFC46883.1 - 2.5 8.5 9.3 13 6.2 2.1 3.4 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF4116 PF13475.6 EFC46884.1 - 0 1030.7 59.3 5.9e-19 67.5 0.0 14.2 2 1 16 21 21 21 20 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC46884.1 - 4.1e-24 85.4 3.8 4.1e-24 85.4 3.8 4.2 3 2 1 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46884.1 - 2.1e-09 37.1 0.3 5.2e-08 32.5 0.1 2.4 2 0 0 2 2 2 1 Protein tyrosine kinase DUF5334 PF17268.2 EFC46884.1 - 1e-05 25.7 0.1 57 4.1 0.0 7.5 4 2 5 10 10 10 0 Family of unknown function (DUF5334) UPF0552 PF10574.9 EFC46884.1 - 0.004 16.5 11.8 21 4.4 0.2 6.1 2 1 4 6 6 6 1 Arp2/3-interacting proteins Arpin TAL_effector PF03377.13 EFC46884.1 - 0.66 10.3 9.9 80 3.7 0.2 6.8 7 0 0 7 7 7 0 TAL effector repeat DUF5638 PF18688.1 EFC46884.1 - 7.3 7.0 19.0 0.07 13.5 2.3 6.3 6 1 2 8 8 8 0 Family of unknown function (DUF5638) Fis1_TPR_C PF14853.6 EFC46884.1 - 7.5 6.7 9.9 93 3.2 0.0 6.0 8 0 0 8 8 8 0 Fis1 C-terminal tetratricopeptide repeat DUF4116 PF13475.6 EFC46886.1 - 6.2e-150 486.9 32.5 1.2e-19 69.7 0.2 10.6 7 1 2 10 10 10 9 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC46886.1 - 3.7e-24 85.5 6.3 4e-24 85.4 3.4 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46886.1 - 7.2e-09 35.3 0.0 1.6e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF5334 PF17268.2 EFC46886.1 - 4.5e-05 23.7 0.0 18 5.7 0.0 5.2 3 1 2 5 5 5 0 Family of unknown function (DUF5334) RelB_leu_zip PF16180.5 EFC46886.1 - 0.00013 21.9 0.5 13 5.9 0.0 6.3 3 2 3 7 7 7 0 RelB leucine zipper AfsA PF03756.13 EFC46886.1 - 0.00046 20.2 0.0 47 4.0 0.0 5.2 1 1 4 6 6 6 0 A-factor biosynthesis hotdog domain YabA PF06156.13 EFC46886.1 - 0.0023 18.6 4.2 0.014 16.0 4.2 2.5 1 0 0 1 1 1 1 Initiation control protein YabA ZapB PF06005.12 EFC46886.1 - 0.0089 16.5 8.3 0.052 14.0 8.3 2.5 1 0 0 1 1 1 1 Cell division protein ZapB DUF3450 PF11932.8 EFC46886.1 - 0.013 14.8 3.1 0.022 14.1 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CENP-H PF05837.12 EFC46886.1 - 0.052 14.0 3.0 0.18 12.2 3.0 2.0 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Tropomyosin_1 PF12718.7 EFC46886.1 - 0.13 12.4 13.8 0.074 13.2 8.1 2.7 2 0 0 2 2 2 0 Tropomyosin like UPF0552 PF10574.9 EFC46886.1 - 0.13 11.6 8.0 5 6.4 0.4 4.0 1 1 4 5 5 5 0 Arp2/3-interacting proteins Arpin DUF4164 PF13747.6 EFC46886.1 - 0.13 12.6 6.0 0.34 11.2 6.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) bZIP_1 PF00170.21 EFC46886.1 - 0.23 11.6 17.7 0.025 14.7 2.7 3.2 2 1 1 3 3 3 0 bZIP transcription factor Lectin_N PF03954.14 EFC46886.1 - 0.42 10.4 7.8 0.18 11.6 1.7 3.1 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain TAL_effector PF03377.13 EFC46886.1 - 0.67 10.3 12.4 23 5.4 0.1 5.4 7 0 0 7 7 3 0 TAL effector repeat bZIP_2 PF07716.15 EFC46886.1 - 0.89 9.7 8.0 3.9 7.6 2.5 2.9 1 1 1 2 2 2 0 Basic region leucine zipper DUF763 PF05559.11 EFC46886.1 - 1 8.5 4.6 2.2e+02 0.8 4.6 3.7 1 1 0 1 1 1 0 Protein of unknown function (DUF763) TSC22 PF01166.18 EFC46886.1 - 1.1 9.7 8.6 1.6 9.1 4.5 3.0 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF1725 PF08333.11 EFC46886.1 - 1.3 8.8 9.5 3.3e+02 1.1 0.0 6.8 6 0 0 6 6 6 0 Protein of unknown function (DUF1725) APC_N_CC PF16689.5 EFC46886.1 - 4.6 7.4 9.0 26 5.0 7.9 2.8 1 1 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain HALZ PF02183.18 EFC46886.1 - 5.1 7.4 10.6 1.3 9.3 3.3 3.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper SpoU_methylase PF00588.19 EFC46888.1 - 1.7e-28 99.5 0.0 2.1e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 SpoU rRNA Methylase family p450 PF00067.22 EFC46889.1 - 2.8e-27 95.6 0.0 3.1e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Bunya_nucleocap PF00952.17 EFC46889.1 - 0.12 12.4 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Bunyavirus nucleocapsid (N) protein Myb_DNA-binding PF00249.31 EFC46890.1 - 1.2e-13 51.0 8.6 7e-07 29.3 0.7 2.8 2 1 1 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC46890.1 - 8.5e-13 48.4 4.5 3.2e-07 30.5 1.3 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFC46890.1 - 0.039 14.2 0.4 0.39 11.0 0.2 2.5 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 Dynamin_N PF00350.23 EFC46891.1 - 0.02 15.0 0.1 0.07 13.2 0.1 2.0 1 0 0 1 1 1 0 Dynamin family p450 PF00067.22 EFC46892.1 - 1.1e-18 67.2 0.1 1.6e-18 66.7 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 CortBP2 PF09727.9 EFC46892.1 - 0.035 14.0 0.6 0.11 12.4 0.2 1.8 2 0 0 2 2 2 0 Cortactin-binding protein-2 DUF2207 PF09972.9 EFC46894.1 - 0.17 10.6 2.6 0.21 10.3 2.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4577 PF15145.6 EFC46894.1 - 0.52 10.3 4.3 1.8 8.6 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) DUF1700 PF08006.11 EFC46894.1 - 7.7 6.0 13.2 7.4 6.1 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) Saf_2TM PF18303.1 EFC46894.1 - 9.7 5.8 9.3 4.1 7.0 2.2 2.5 1 1 2 3 3 3 0 SAVED-fused 2TM effector domain Pkinase PF00069.25 EFC46895.1 - 4.5e-25 88.5 8.5 5.4e-25 88.3 4.7 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46895.1 - 3.9e-10 39.4 0.1 5.1e-09 35.8 0.1 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC46895.1 - 0.011 14.6 0.0 0.015 14.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase bZIP_1 PF00170.21 EFC46895.1 - 0.034 14.2 16.4 0.096 12.8 2.8 3.3 2 1 1 3 3 3 0 bZIP transcription factor Kdo PF06293.14 EFC46895.1 - 0.061 12.7 0.3 0.14 11.5 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fib_alpha PF08702.10 EFC46895.1 - 0.096 12.9 0.2 0.096 12.9 0.2 2.9 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family JIP_LZII PF16471.5 EFC46895.1 - 0.1 12.8 10.2 0.35 11.1 10.2 2.0 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II HALZ PF02183.18 EFC46895.1 - 0.12 12.6 7.9 0.47 10.7 1.0 3.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF1515 PF07439.11 EFC46895.1 - 0.4 10.7 2.7 0.47 10.5 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) TSC22 PF01166.18 EFC46895.1 - 0.56 10.6 13.1 4.7 7.6 1.8 3.3 1 1 1 2 2 2 0 TSC-22/dip/bun family ZapB PF06005.12 EFC46895.1 - 2.6 8.5 11.1 2.3e+02 2.3 11.1 2.8 1 1 0 1 1 1 0 Cell division protein ZapB bZIP_2 PF07716.15 EFC46895.1 - 3.9 7.6 11.4 3 8.0 1.4 2.8 2 0 0 2 2 2 0 Basic region leucine zipper Peptidase_M56 PF05569.11 EFC46896.1 - 0.066 12.4 3.6 0.11 11.7 3.6 1.4 1 0 0 1 1 1 0 BlaR1 peptidase M56 S6PP PF05116.13 EFC46896.1 - 1.1 8.7 5.9 6.2 6.3 0.2 2.3 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase SIP1 PF04938.12 EFC46896.1 - 4.4 7.0 12.0 2.1 8.0 9.3 1.7 1 1 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) SBP_bac_3 PF00497.20 EFC46897.1 - 1.9e-11 43.9 0.0 1e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 Aldose_epim PF01263.20 EFC46900.1 - 1.6e-24 86.7 0.1 6.8e-24 84.7 0.1 1.8 1 1 0 1 1 1 1 Aldose 1-epimerase SNF2_N PF00176.23 EFC46901.1 - 2.1e-56 191.2 0.0 3.5e-56 190.4 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC46901.1 - 5.8e-20 71.7 0.7 7.4e-19 68.1 0.0 3.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC46901.1 - 1e-11 45.1 4.8 5.5e-11 42.8 0.0 3.7 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit Macro PF01661.21 EFC46901.1 - 8.3e-10 38.7 0.1 3.7e-09 36.6 0.1 2.0 2 0 0 2 2 2 1 Macro domain DEAD PF00270.29 EFC46901.1 - 1.6e-06 28.0 0.0 3.2e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 EFC46901.1 - 0.0029 16.8 0.0 0.0063 15.7 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DAG_kinase_N PF14513.6 EFC46902.1 - 0.0025 18.1 3.3 0.0027 17.9 3.3 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus Nitroreductase PF00881.24 EFC46903.1 - 1.2e-08 35.2 0.0 0.0042 17.2 0.0 3.4 2 1 1 3 3 3 3 Nitroreductase family TM1586_NiRdase PF14512.6 EFC46903.1 - 0.024 14.2 0.0 0.87 9.1 0.0 2.6 2 0 0 2 2 2 0 Putative TM nitroreductase Sel1 PF08238.12 EFC46904.1 - 4.1e-46 154.4 35.1 1.6e-07 31.8 0.3 12.8 12 2 0 12 12 12 10 Sel1 repeat TPR_6 PF13174.6 EFC46904.1 - 7.7e-06 26.2 27.1 13 6.7 0.3 10.3 11 1 1 12 12 11 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC46904.1 - 0.0001 22.9 7.9 0.67 10.6 0.1 5.9 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46904.1 - 0.00054 20.2 22.6 0.37 11.1 0.1 7.6 7 3 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC46904.1 - 0.00056 19.6 32.3 0.02 14.7 0.3 8.9 9 0 0 9 9 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC46904.1 - 0.00064 19.9 0.4 0.00064 19.9 0.4 4.3 4 2 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 UBA PF00627.31 EFC46904.1 - 0.022 14.7 0.3 0.2 11.6 0.1 2.8 2 0 0 2 2 2 0 UBA/TS-N domain TPR_2 PF07719.17 EFC46904.1 - 0.024 14.7 35.2 0.078 13.1 0.2 9.7 11 1 1 12 12 12 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC46904.1 - 0.029 14.9 13.9 0.41 11.2 0.1 5.6 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC46904.1 - 0.049 13.9 0.2 0.049 13.9 0.2 10.4 12 2 2 14 14 14 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC46904.1 - 0.05 13.6 12.2 0.21 11.7 0.1 6.2 7 0 0 7 7 6 0 Tetratricopeptide repeat NAD_binding_8 PF13450.6 EFC46904.1 - 0.071 13.4 0.0 2.1 8.6 0.0 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain PPR_2 PF13041.6 EFC46904.1 - 0.081 13.1 1.2 0.28 11.4 0.1 2.4 2 0 0 2 2 2 0 PPR repeat family TPR_14 PF13428.6 EFC46904.1 - 0.085 13.7 6.8 16 6.6 0.0 6.2 6 3 3 9 9 8 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC46904.1 - 0.097 13.1 13.2 7.3 7.2 0.1 7.3 5 3 4 9 9 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC46904.1 - 5.5 6.7 16.5 5.4 6.8 0.3 6.0 5 1 0 5 5 5 0 TPR repeat GPS PF01825.21 EFC46905.1 - 1.8e-11 44.3 8.2 3.9e-11 43.3 8.2 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif RdRP PF05183.12 EFC46906.1 - 4.5e-52 177.5 0.7 1.1e-51 176.2 0.7 1.6 1 0 0 1 1 1 1 RNA dependent RNA polymerase PCMT PF01135.19 EFC46909.1 - 3e-19 69.6 0.0 3.5e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 EFC46909.1 - 0.00023 21.0 0.1 0.00034 20.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFC46909.1 - 0.0035 17.4 0.0 0.0049 16.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC46909.1 - 0.0035 18.0 0.0 0.0085 16.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFC46909.1 - 0.029 13.8 0.1 0.037 13.4 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_24 PF13578.6 EFC46909.1 - 0.096 13.7 0.0 0.16 13.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 EFC46909.1 - 0.1 11.9 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_11 PF08241.12 EFC46909.1 - 0.1 13.2 0.0 0.31 11.7 0.0 1.7 2 1 1 3 3 3 0 Methyltransferase domain Ubie_methyltran PF01209.18 EFC46909.1 - 0.17 11.2 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family LRR_6 PF13516.6 EFC46910.1 - 2.3e-18 64.6 25.8 0.0034 17.3 0.0 9.7 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.7 EFC46910.1 - 6.4e-15 55.0 30.5 0.00056 20.2 1.8 6.5 3 3 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC46910.1 - 2.9e-13 49.4 26.8 3.3e-06 26.7 3.9 5.9 2 2 4 6 6 6 5 Leucine rich repeat LRR_1 PF00560.33 EFC46910.1 - 3.3e-06 26.9 18.4 2.7 8.9 0.0 8.1 7 1 0 7 7 7 2 Leucine Rich Repeat F-box PF00646.33 EFC46910.1 - 0.00077 19.3 0.1 0.0031 17.3 0.0 2.1 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC46910.1 - 0.0022 17.8 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like DUF4347 PF14252.6 EFC46910.1 - 0.0065 16.3 1.2 4.6 7.1 0.4 3.7 1 1 2 3 3 3 1 Domain of unknown function (DUF4347) DUF1492 PF07374.11 EFC46910.1 - 0.12 12.5 1.4 0.43 10.8 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1492) VirE_N PF08800.10 EFC46910.1 - 0.14 12.2 0.0 0.52 10.4 0.0 1.9 2 0 0 2 2 2 0 VirE N-terminal domain 2OG-FeII_Oxy_3 PF13640.6 EFC46912.1 - 4.7e-11 43.4 0.0 7.9e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFC46912.1 - 0.0022 17.2 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein 2OG-FeII_Oxy PF03171.20 EFC46912.1 - 0.0065 16.9 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EFC46913.1 - 0.13 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 F-box-like Snf7 PF03357.21 EFC46914.1 - 3.3e-12 46.3 16.5 5.7e-12 45.6 15.8 1.6 1 1 1 2 2 2 1 Snf7 Ist1 PF03398.14 EFC46914.1 - 0.0054 16.7 5.4 0.0054 16.7 5.4 2.4 2 1 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway MtrB PF05440.12 EFC46914.1 - 0.014 15.8 0.7 0.19 12.2 0.1 2.3 2 1 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B F-box-like PF12937.7 EFC46915.1 - 0.082 12.8 0.1 0.23 11.4 0.0 1.8 2 0 0 2 2 2 0 F-box-like CLP1_P PF16575.5 EFC46917.1 - 6.3e-41 140.2 0.4 1e-40 139.6 0.4 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 EFC46917.1 - 0.011 15.9 0.0 0.058 13.5 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase Clp1 PF06807.14 EFC46917.1 - 0.011 16.1 0.1 0.024 15.1 0.1 1.6 1 0 0 1 1 1 0 Pre-mRNA cleavage complex II protein Clp1 FtsK_SpoIIIE PF01580.18 EFC46917.1 - 0.015 14.7 0.0 0.19 11.1 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family GTP_EFTU PF00009.27 EFC46917.1 - 0.016 14.8 0.0 0.034 13.7 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 EFC46917.1 - 0.034 13.9 0.0 0.09 12.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Nepo_coat_C PF03688.14 EFC46917.1 - 0.039 13.8 0.0 0.24 11.2 0.0 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, C-terminal domain Sigma54_activat PF00158.26 EFC46917.1 - 0.084 12.6 0.0 0.2 11.3 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain Exop_C PF18559.1 EFC46917.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Galactose-binding domain-like IlvN PF07991.12 EFC46917.1 - 0.12 11.9 0.0 0.37 10.3 0.0 1.8 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ABC_tran PF00005.27 EFC46917.1 - 0.49 10.9 3.2 1.9 9.0 3.2 2.1 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 EFC46917.1 - 0.49 10.9 4.7 11 6.4 4.7 2.3 1 1 0 1 1 1 0 AAA domain E1-E2_ATPase PF00122.20 EFC46919.1 - 5.6e-48 162.9 2.0 5.6e-48 162.9 2.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC46919.1 - 4.6e-30 105.5 0.0 7.7e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 EFC46919.1 - 3.8e-17 62.5 0.3 1e-16 61.1 0.3 1.8 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 EFC46919.1 - 0.0016 18.2 2.0 0.012 15.4 2.0 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase UL41A PF17591.2 EFC46919.1 - 0.05 13.7 1.1 0.17 12.0 0.2 2.2 2 0 0 2 2 2 0 Herpesvirus UL41A HAD PF12710.7 EFC46919.1 - 0.14 12.6 0.0 0.47 10.8 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Zn_Tnp_IS1595 PF12760.7 EFC46920.1 - 0.00038 20.4 1.6 0.00038 20.4 1.6 1.8 2 0 0 2 2 2 1 Transposase zinc-ribbon domain DUF2387 PF09526.10 EFC46920.1 - 0.0011 19.1 1.4 0.0011 19.1 1.4 1.7 1 1 1 2 2 2 1 Probable metal-binding protein (DUF2387) Elf1 PF05129.13 EFC46920.1 - 0.0028 17.7 3.5 0.0028 17.7 3.5 1.8 1 1 1 2 2 2 1 Transcription elongation factor Elf1 like RdRP PF05183.12 EFC46921.1 - 1.3e-53 182.6 0.1 2e-53 182.0 0.1 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Phage_sheath_1C PF17482.2 EFC46921.1 - 0.053 13.5 0.5 2.4 8.2 0.1 3.3 3 0 0 3 3 3 0 Phage tail sheath C-terminal domain DHR-2 PF06920.13 EFC46922.1 - 1e-61 209.2 33.4 3.4e-39 134.9 16.1 3.7 4 0 0 4 4 4 2 Dock homology region 2 DOCK_N PF16172.5 EFC46922.1 - 2.4e-42 145.2 1.5 2e-41 142.2 0.5 2.4 2 0 0 2 2 2 1 DOCK N-terminus DOCK-C2 PF14429.6 EFC46922.1 - 3.1e-21 76.1 2.6 6.4e-20 71.8 3.6 2.5 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins SPX PF03105.19 EFC46922.1 - 0.0095 15.9 16.3 0.022 14.7 16.3 1.5 1 0 0 1 1 1 1 SPX domain C2 PF00168.30 EFC46922.1 - 0.092 13.0 0.1 1.2 9.5 0.0 2.8 2 0 0 2 2 2 0 C2 domain Gb3_synth PF04572.12 EFC46922.1 - 0.52 10.5 3.3 0.41 10.8 0.7 2.2 2 0 0 2 2 2 0 Alpha 1,4-glycosyltransferase conserved region AI-2E_transport PF01594.16 EFC46923.1 - 1.1e-15 57.6 21.3 1.1e-15 57.6 21.3 3.0 2 1 1 3 3 3 1 AI-2E family transporter Ecm29 PF13001.7 EFC46924.1 - 6.8e-118 394.5 17.7 1.2e-117 393.6 6.0 3.7 3 0 0 3 3 3 2 Proteasome stabiliser Dynein_AAA_lid PF17852.1 EFC46924.1 - 0.0017 18.4 0.0 0.018 15.1 0.0 2.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain HEAT PF02985.22 EFC46924.1 - 0.0039 17.3 2.2 0.75 10.2 0.0 5.6 7 0 0 7 7 7 1 HEAT repeat CLASP_N PF12348.8 EFC46924.1 - 0.0054 16.3 0.5 2.5 7.6 0.0 4.9 3 2 1 5 5 5 1 CLASP N terminal HEAT_EZ PF13513.6 EFC46924.1 - 0.022 15.3 3.1 7.4 7.2 0.0 5.4 6 0 0 6 6 6 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EFC46924.1 - 0.088 13.4 0.1 3.8 8.2 0.0 3.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region CTD_bind PF04818.13 EFC46924.1 - 0.36 11.7 7.6 4.6 8.1 0.0 6.4 8 0 0 8 8 8 0 RNA polymerase II-binding domain. ADK PF00406.22 EFC46925.1 - 2.7e-49 167.1 0.0 3.2e-49 166.9 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 EFC46925.1 - 7.7e-36 123.5 0.0 9.4e-36 123.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC46925.1 - 2.8e-10 40.9 0.0 4.2e-10 40.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 EFC46925.1 - 1.5e-06 28.0 0.7 0.0092 15.7 0.1 2.3 1 1 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 EFC46925.1 - 2.7e-05 24.4 0.0 6.3e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain Rad60-SLD PF11976.8 EFC46925.1 - 0.0089 15.8 0.2 0.1 12.4 0.2 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like dNK PF01712.19 EFC46925.1 - 0.027 14.3 0.1 0.11 12.4 0.0 1.8 2 0 0 2 2 2 0 Deoxynucleoside kinase UCH PF00443.29 EFC46926.1 - 1.3e-52 178.8 0.7 1.3e-52 178.8 0.7 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC46926.1 - 2.4e-22 79.9 0.0 2.4e-22 79.9 0.0 3.3 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 EFC46926.1 - 0.0013 18.4 8.8 0.035 13.9 0.0 4.8 4 1 0 4 4 4 2 Ubiquitin family UN_NPL4 PF11543.8 EFC46926.1 - 0.0051 17.3 3.0 5.6 7.5 0.0 4.0 4 0 0 4 4 4 2 Nuclear pore localisation protein NPL4 RA PF00788.23 EFC46926.1 - 0.054 14.1 0.9 6.3 7.5 0.0 2.8 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain DUF3107 PF11305.8 EFC46926.1 - 0.75 10.1 2.8 2.2 8.6 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3107) BAR_3_WASP_bdg PF10456.9 EFC46928.1 - 0.014 14.8 0.2 0.019 14.5 0.2 1.2 1 0 0 1 1 1 0 WASP-binding domain of Sorting nexin protein Pox_A12 PF04651.13 EFC46928.1 - 0.067 13.3 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A12 protein dCache_1 PF02743.18 EFC46929.1 - 1.2e-05 25.3 5.1 2.8e-05 24.0 5.1 1.7 1 0 0 1 1 1 1 Cache domain Guanylate_cyc PF00211.20 EFC46929.1 - 0.0005 19.8 3.6 0.00079 19.1 0.5 2.6 2 1 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Glyco_transf_8 PF01501.20 EFC46929.1 - 0.1 12.1 5.1 0.28 10.7 1.9 2.5 2 0 0 2 2 2 0 Glycosyl transferase family 8 GUCT PF08152.12 EFC46929.1 - 0.15 12.3 3.7 3.4 8.0 0.0 3.2 3 0 0 3 3 3 0 GUCT (NUC152) domain DUF327 PF03885.13 EFC46929.1 - 0.26 11.3 4.0 2.6 8.0 1.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF327) DUF5344 PF17279.2 EFC46929.1 - 2.5 8.7 5.9 0.91 10.1 1.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DPBB_1 PF03330.18 EFC46930.1 - 0.0002 21.5 2.1 0.0002 21.5 2.1 2.8 3 1 0 3 3 3 1 Lytic transglycolase PAP2 PF01569.21 EFC46932.1 - 1.3e-09 37.9 0.1 3.3e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 PAP2 superfamily VCPO_N PF17897.1 EFC46932.1 - 0.0022 17.8 0.0 0.0096 15.7 0.0 2.1 2 0 0 2 2 2 1 Vanadium chloroperoxidase N-terminal domain CIAPIN1 PF05093.13 EFC46933.1 - 2.5e-19 69.6 16.8 5.3e-16 59.0 2.4 2.7 2 1 1 3 3 3 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Kelch_1 PF01344.25 EFC46934.1 - 9e-43 143.6 19.1 1.6e-10 40.4 1.3 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 EFC46934.1 - 1.2e-41 140.2 3.2 1.9e-09 37.6 0.0 6.7 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC46934.1 - 7.1e-38 127.7 10.9 1.6e-07 31.4 0.3 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 EFC46934.1 - 9.5e-31 105.3 15.3 8.3e-06 25.7 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 EFC46934.1 - 1.5e-29 101.7 9.1 1.9e-05 24.5 0.0 6.1 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC46934.1 - 4.9e-26 89.7 21.5 5.9e-05 22.9 0.0 6.4 6 0 0 6 6 6 6 Kelch motif NHL PF01436.21 EFC46935.1 - 5.6e-11 41.9 3.3 0.00044 20.1 0.0 4.3 4 0 0 4 4 4 2 NHL repeat GPS PF01825.21 EFC46935.1 - 1.5e-06 28.6 6.3 3.3e-06 27.5 6.3 1.6 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif RGS PF00615.19 EFC46935.1 - 0.00012 22.4 4.5 0.00012 22.4 4.5 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain SGL PF08450.12 EFC46935.1 - 0.00034 20.3 0.2 0.015 14.9 0.1 2.6 2 1 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region LysE PF01810.18 EFC46935.1 - 0.0082 15.6 10.7 0.072 12.5 2.8 3.5 3 0 0 3 3 3 1 LysE type translocator EGF_2 PF07974.13 EFC46935.1 - 0.15 12.5 6.2 0.45 10.9 6.2 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFC46935.1 - 1.3 9.1 9.7 3 8.0 9.7 1.6 1 0 0 1 1 1 0 Tenascin EGF domain Bac_export_2 PF01312.19 EFC46935.1 - 7 5.8 10.5 24 4.0 10.5 1.9 1 1 0 1 1 1 0 FlhB HrpN YscU SpaS Family PIG-F PF06699.11 EFC46935.1 - 8.5 6.5 9.5 2.4 8.3 5.3 2.3 2 0 0 2 2 2 0 GPI biosynthesis protein family Pig-F DUF1647 PF07801.11 EFC46937.1 - 0.031 14.0 0.1 0.072 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1647) KHA PF11834.8 EFC46937.1 - 0.065 13.3 0.0 0.7 10.0 0.0 2.4 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel AAA_5 PF07728.14 EFC46939.1 - 6.6e-112 369.5 0.0 6.4e-24 84.5 0.0 9.1 8 0 0 8 8 8 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 EFC46939.1 - 2e-50 169.4 14.0 3.6e-17 62.5 0.1 8.1 8 0 0 8 8 7 3 Midasin AAA lid domain AAA_3 PF07726.11 EFC46939.1 - 1.4e-30 105.8 0.0 7.5e-11 42.0 0.0 6.6 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 EFC46939.1 - 2e-30 105.0 1.5 1.5e-29 102.2 0.1 3.4 3 0 0 3 3 2 1 Midasin AAA lid domain AAA PF00004.29 EFC46939.1 - 2.6e-20 73.2 10.3 3.1e-05 24.4 0.0 8.1 8 0 0 8 8 6 4 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 EFC46939.1 - 4.4e-20 72.0 0.0 0.0032 17.5 0.0 8.1 7 0 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 EFC46939.1 - 1.3e-15 57.4 12.2 0.00015 21.3 0.1 6.5 6 0 0 6 6 6 4 P-loop containing dynein motor region AAA_16 PF13191.6 EFC46939.1 - 1.2e-14 55.1 0.4 0.42 11.0 0.0 8.0 7 0 0 7 7 6 4 AAA ATPase domain AAA_6 PF12774.7 EFC46939.1 - 2.6e-13 49.7 9.8 0.061 12.3 0.0 8.4 9 0 0 9 9 9 4 Hydrolytic ATP binding site of dynein motor region TsaE PF02367.17 EFC46939.1 - 8.2e-13 48.5 1.7 0.039 13.9 0.0 5.7 5 0 0 5 5 5 3 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 EFC46939.1 - 2.4e-12 47.5 11.1 1 9.9 0.0 10.0 8 0 0 8 8 7 3 AAA domain AAA_22 PF13401.6 EFC46939.1 - 8.2e-12 45.6 2.1 0.03 14.6 0.5 7.3 6 1 0 6 6 5 1 AAA domain Sigma54_activat PF00158.26 EFC46939.1 - 9.1e-11 41.7 0.0 0.074 12.7 0.0 5.5 6 0 0 6 6 5 3 Sigma-54 interaction domain RuvB_N PF05496.12 EFC46939.1 - 5.2e-10 39.3 0.7 0.059 13.1 0.0 5.7 5 0 0 5 5 5 3 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 EFC46939.1 - 6.3e-10 39.1 0.0 0.12 12.0 0.0 6.4 6 1 0 6 6 6 2 AAA domain AAA_33 PF13671.6 EFC46939.1 - 6.5e-07 29.6 0.0 4.1 7.6 0.0 5.9 5 0 0 5 5 5 1 AAA domain VWA_2 PF13519.6 EFC46939.1 - 2.3e-05 25.0 1.7 0.0001 22.9 0.1 3.1 2 0 0 2 2 1 1 von Willebrand factor type A domain Sigma54_activ_2 PF14532.6 EFC46939.1 - 0.00016 21.8 0.1 5 7.2 0.0 4.9 4 0 0 4 4 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 EFC46939.1 - 0.00018 21.8 2.7 31 5.0 0.0 6.6 6 0 0 6 6 6 0 RNA helicase Mg_chelatase PF01078.21 EFC46939.1 - 0.00019 20.9 1.8 26 4.1 0.0 6.5 7 1 0 8 8 7 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 EFC46939.1 - 0.00028 20.0 5.8 1.4 7.9 0.0 5.7 6 0 0 6 6 5 1 Type II/IV secretion system protein NACHT PF05729.12 EFC46939.1 - 0.00041 20.3 0.3 5.9 6.8 0.0 5.6 5 0 0 5 5 5 0 NACHT domain CPT PF07931.12 EFC46939.1 - 0.0006 19.7 1.6 3.3 7.5 0.0 5.1 5 0 0 5 5 5 1 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.6 EFC46939.1 - 0.0012 18.4 0.5 4 7.0 0.0 4.3 5 0 0 5 5 4 1 AAA domain ATP_bind_1 PF03029.17 EFC46939.1 - 0.0012 18.6 0.9 2.3 7.9 0.0 5.1 4 0 0 4 4 4 1 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 EFC46939.1 - 0.0013 19.1 2.5 7.7 6.8 0.0 5.7 6 0 0 6 6 4 0 AAA domain TniB PF05621.11 EFC46939.1 - 0.0014 18.1 3.7 5.8 6.3 0.0 5.2 6 0 0 6 6 6 0 Bacterial TniB protein AAA_29 PF13555.6 EFC46939.1 - 0.0014 18.3 1.2 18 5.1 0.0 4.9 5 0 0 5 5 5 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EFC46939.1 - 0.0059 16.9 3.7 10 6.3 0.0 4.8 5 0 0 5 5 4 0 AAA domain Roc PF08477.13 EFC46939.1 - 0.0067 16.6 0.2 40 4.5 0.0 5.1 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase IstB_IS21 PF01695.17 EFC46939.1 - 0.016 15.0 0.0 3 7.5 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_23 PF13476.6 EFC46939.1 - 0.027 15.0 0.1 0.027 15.0 0.1 18.3 13 6 1 14 14 4 0 AAA domain PduV-EutP PF10662.9 EFC46939.1 - 0.04 13.7 1.3 11 5.8 0.0 4.6 5 0 0 5 5 5 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 EFC46939.1 - 0.15 11.9 15.3 3 7.7 0.0 6.5 7 0 0 7 7 6 0 RsgA GTPase SRP54 PF00448.22 EFC46939.1 - 0.19 11.3 2.3 9.5 5.8 0.0 4.3 5 0 0 5 5 5 0 SRP54-type protein, GTPase domain DUF4845 PF16137.5 EFC46939.1 - 0.21 12.5 6.3 2.3 9.1 2.4 4.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4845) ABC_tran PF00005.27 EFC46939.1 - 0.33 11.5 25.3 3.4 8.2 0.1 7.8 6 0 0 6 6 5 0 ABC transporter Thioredoxin PF00085.20 EFC46942.1 - 2.3e-27 95.0 0.4 3.7e-27 94.3 0.4 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFC46942.1 - 3.5e-07 30.4 2.0 1.5e-05 25.3 0.2 2.8 1 1 2 3 3 3 1 Thioredoxin-like OST3_OST6 PF04756.13 EFC46942.1 - 4.1e-05 23.1 0.1 4.7e-05 22.9 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 EFC46942.1 - 5.7e-05 23.0 0.3 9.7e-05 22.3 0.3 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 EFC46942.1 - 0.00014 22.2 0.3 0.00037 20.9 0.3 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EFC46942.1 - 0.00027 20.6 0.7 0.014 15.1 0.4 2.2 1 1 1 2 2 2 1 Redoxin HyaE PF07449.11 EFC46942.1 - 0.0055 16.7 0.0 0.0083 16.1 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_9 PF14595.6 EFC46942.1 - 0.0098 15.7 0.1 0.013 15.3 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 EFC46942.1 - 0.02 15.0 0.3 0.038 14.2 0.3 1.4 1 0 0 1 1 1 0 Thioredoxin-like T4_deiodinase PF00837.17 EFC46942.1 - 0.045 13.0 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Iodothyronine deiodinase TraF PF13728.6 EFC46942.1 - 0.079 12.8 0.1 0.091 12.6 0.1 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein TrbC_Ftype PF09673.10 EFC46942.1 - 0.082 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein EF-hand_4 PF12763.7 EFC46943.1 - 1.6e-10 40.9 0.0 1.2e-09 38.0 0.0 2.3 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand CALCOCO1 PF07888.11 EFC46943.1 - 0.0001 21.3 31.8 0.00016 20.7 31.8 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like EF-hand_1 PF00036.32 EFC46943.1 - 0.0027 17.1 7.0 0.035 13.7 0.1 4.3 4 0 0 4 4 4 1 EF hand EF-hand_6 PF13405.6 EFC46943.1 - 0.003 17.4 3.5 0.29 11.2 0.1 4.7 4 0 0 4 4 4 1 EF-hand domain CENP-F_leu_zip PF10473.9 EFC46943.1 - 0.011 15.8 41.2 0.36 10.8 14.1 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 EFC46943.1 - 0.018 14.4 36.8 0.087 12.2 13.0 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 EFC46943.1 - 0.078 13.5 43.3 0.37 11.3 18.2 3.0 2 1 1 3 3 3 0 Apg6 coiled-coil region Sin3_corepress PF08295.12 EFC46943.1 - 0.12 12.4 2.7 0.43 10.7 2.7 1.9 1 0 0 1 1 1 0 Sin3 family co-repressor DUF724 PF05266.14 EFC46943.1 - 0.13 12.1 31.4 0.5 10.2 0.6 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF724) zf-C4H2 PF10146.9 EFC46943.1 - 0.17 12.1 23.2 8 6.7 23.2 2.8 1 1 0 1 1 1 0 Zinc finger-containing protein Filament PF00038.21 EFC46943.1 - 0.6 9.6 33.2 1.1 8.8 33.2 1.3 1 0 0 1 1 1 0 Intermediate filament protein FPP PF05911.11 EFC46943.1 - 0.78 7.8 33.4 2.4 6.2 19.9 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil CENP-H PF05837.12 EFC46943.1 - 1 9.8 26.8 0.91 10.0 9.8 2.8 2 1 1 3 3 3 0 Centromere protein H (CENP-H) WEMBL PF05701.11 EFC46943.1 - 1.2 7.8 31.4 0.73 8.5 4.6 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light BRE1 PF08647.11 EFC46943.1 - 2 8.5 34.3 1.6 8.8 6.7 4.1 2 1 2 4 4 4 0 BRE1 E3 ubiquitin ligase Aha1_N PF09229.11 EFC46943.1 - 2.8 8.2 6.3 0.69 10.1 2.5 2.0 2 0 0 2 2 2 0 Activator of Hsp90 ATPase, N-terminal Spc7 PF08317.11 EFC46943.1 - 7.5 5.3 38.1 3.8 6.3 15.1 2.9 1 1 3 4 4 4 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 EFC46943.1 - 8.1 5.8 41.1 0.65 9.4 19.9 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 TMA7 PF09072.10 EFC46944.1 - 4e-12 46.8 16.8 4e-12 46.8 16.8 2.1 2 0 0 2 2 2 1 Translation machinery associated TMA7 DUF4749 PF15936.5 EFC46945.1 - 9.3 7.4 10.3 0.89 10.7 2.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4749) Asparaginase PF00710.20 EFC46947.1 - 3.4e-63 212.7 0.0 5.2e-63 212.1 0.0 1.3 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 EFC46947.1 - 1.3e-30 106.0 0.0 1.9e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain SHIPPO-rpt PF07004.12 EFC46948.1 - 0.087 13.8 8.4 0.15 13.0 0.0 4.6 5 0 0 5 5 5 0 Sperm-tail PG-rich repeat tRNA-synt_2 PF00152.20 EFC46949.1 - 1.1e-83 281.0 0.3 1.5e-83 280.5 0.3 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 EFC46949.1 - 5.5e-08 32.6 0.2 0.0011 18.5 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 EFC46949.1 - 9.8e-08 31.9 0.0 1.9e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Hydrolase_4 PF12146.8 EFC46950.1 - 0.0001 21.7 0.0 0.002 17.5 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 PCAF_N PF06466.11 EFC46950.1 - 0.00016 21.3 0.1 0.00021 20.9 0.1 1.1 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Chlorophyllase2 PF12740.7 EFC46950.1 - 0.0055 15.6 0.1 0.032 13.1 0.0 1.9 2 0 0 2 2 2 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 EFC46950.1 - 0.025 14.4 0.1 0.14 11.9 0.0 1.9 1 1 1 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 EFC46950.1 - 0.23 11.1 0.0 0.66 9.6 0.0 1.7 1 1 0 1 1 1 0 Putative esterase E1-E2_ATPase PF00122.20 EFC46951.1 - 1.7e-34 118.9 2.2 3.1e-34 118.1 0.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC46951.1 - 2.7e-16 60.5 0.0 6.8e-10 39.6 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC46951.1 - 7.2e-06 26.0 0.0 1.5e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC46951.1 - 2.7e-05 23.8 0.0 5.8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC46951.1 - 0.026 14.3 0.0 4.3 7.0 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF2620 PF10941.8 EFC46951.1 - 0.049 13.8 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF2620 Ashwin PF15323.6 EFC46952.1 - 0.27 11.3 15.3 0.32 11.0 15.3 1.1 1 0 0 1 1 1 0 Developmental protein Macoilin PF09726.9 EFC46952.1 - 0.29 9.7 10.1 0.26 9.8 10.1 1.0 1 0 0 1 1 1 0 Macoilin family IMUP PF15761.5 EFC46952.1 - 0.33 11.7 17.8 0.46 11.2 17.8 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein Presenilin PF01080.17 EFC46952.1 - 8 5.1 5.6 7.8 5.2 5.6 1.1 1 0 0 1 1 1 0 Presenilin Bromodomain PF00439.25 EFC46953.1 - 1.9e-74 245.7 22.4 7e-20 70.9 0.7 4.8 4 0 0 4 4 4 4 Bromodomain Ribosomal_S24e PF01282.19 EFC46954.1 - 2.1e-27 94.9 0.0 3.9e-27 94.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e Rhv PF00073.20 EFC46955.1 - 0.034 13.8 0.0 0.056 13.1 0.0 1.4 1 0 0 1 1 1 0 picornavirus capsid protein Microtub_bd PF16796.5 EFC46956.1 - 1.3e-10 41.4 0.6 2.2e-10 40.7 0.1 1.6 2 0 0 2 2 2 1 Microtubule binding FliJ PF02050.16 EFC46956.1 - 0.004 17.4 2.2 0.0077 16.5 2.2 1.4 1 0 0 1 1 1 1 Flagellar FliJ protein Kinesin PF00225.23 EFC46956.1 - 0.0067 15.4 1.6 0.055 12.4 0.1 2.1 2 0 0 2 2 2 1 Kinesin motor domain FadA PF09403.10 EFC46956.1 - 0.0072 16.8 0.7 0.016 15.7 0.7 1.5 1 0 0 1 1 1 1 Adhesion protein FadA SPATA1_C PF15743.5 EFC46956.1 - 0.02 15.0 1.5 0.028 14.5 1.5 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Kinesin PF00225.23 EFC46957.1 - 3.9e-79 266.0 3.5 4.4e-79 265.8 3.5 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC46957.1 - 4.3e-18 65.7 1.4 4.3e-18 65.7 1.4 1.9 2 0 0 2 2 2 1 Microtubule binding C2-set PF05790.15 EFC46957.1 - 0.0027 17.8 2.9 0.039 14.1 0.5 2.4 1 1 1 2 2 2 1 Immunoglobulin C2-set domain Bac_DnaA PF00308.18 EFC46957.1 - 0.082 12.7 0.6 0.34 10.7 0.1 1.9 1 1 1 2 2 2 0 Bacterial dnaA protein DUF3942 PF13078.6 EFC46957.1 - 0.087 13.1 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) RNase_H PF00075.24 EFC46958.1 - 3.5e-17 62.9 1.4 9.1e-17 61.6 1.4 1.7 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 EFC46958.1 - 0.0036 17.1 0.0 0.007 16.2 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase-like zf-RVT PF13966.6 EFC46958.1 - 0.0082 16.8 1.8 0.027 15.2 0.5 2.6 1 1 1 2 2 2 1 zinc-binding in reverse transcriptase dCMP_cyt_deam_1 PF00383.23 EFC46958.1 - 0.098 12.5 0.2 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region ABC2_membrane_3 PF12698.7 EFC46958.1 - 3.6 6.6 5.6 4.6 6.2 4.7 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein ORC2 PF04084.14 EFC46961.1 - 9.3e-34 116.8 0.2 1.1e-33 116.5 0.2 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 ERp29 PF07749.12 EFC46961.1 - 0.15 12.9 2.1 0.42 11.5 0.6 2.2 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Pho86 PF11124.8 EFC46962.1 - 2.1 7.8 11.0 3 7.2 3.0 2.1 1 1 1 2 2 2 0 Inorganic phosphate transporter Pho86 AcetylCoA_hydro PF02550.15 EFC46963.1 - 7.4e-46 156.6 0.0 1.2e-45 156.0 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 EFC46963.1 - 1.3e-40 138.9 0.0 2.6e-40 137.9 0.0 1.6 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain YL1 PF05764.13 EFC46964.1 - 3.2e-05 24.2 4.3 3.2e-05 24.2 4.3 2.2 2 0 0 2 2 2 1 YL1 nuclear protein CCDC106 PF15794.5 EFC46964.1 - 0.00012 21.8 3.7 0.00012 21.8 3.7 2.1 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 106 F-box PF00646.33 EFC46964.1 - 0.005 16.7 0.6 0.0088 15.9 0.6 1.4 1 0 0 1 1 1 1 F-box domain CDC45 PF02724.14 EFC46964.1 - 0.006 14.9 9.8 0.0045 15.4 5.8 2.2 2 0 0 2 2 2 1 CDC45-like protein F-box-like PF12937.7 EFC46964.1 - 0.027 14.4 0.2 0.055 13.4 0.2 1.4 1 0 0 1 1 1 0 F-box-like BUD22 PF09073.10 EFC46964.1 - 0.034 13.5 16.2 0.19 11.0 13.8 2.3 2 0 0 2 2 2 0 BUD22 Herpes_LMP1 PF05297.11 EFC46964.1 - 0.093 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) SURF2 PF05477.11 EFC46964.1 - 0.21 11.3 15.5 0.5 10.0 11.2 2.2 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Coilin_N PF15862.5 EFC46964.1 - 0.25 11.1 11.3 0.24 11.2 6.0 2.9 3 0 0 3 3 3 0 Coilin N-terminus DUF4614 PF15391.6 EFC46964.1 - 0.3 11.1 9.3 0.03 14.3 2.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Cwf_Cwc_15 PF04889.12 EFC46964.1 - 0.4 10.4 16.8 0.88 9.2 9.6 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 EFC46964.1 - 0.48 10.1 10.5 2.9 7.6 0.0 2.6 2 0 0 2 2 2 0 FAM176 family CBM32 PF18344.1 EFC46964.1 - 1.5 8.7 4.6 4.2 7.3 0.2 3.6 3 1 0 3 3 3 0 Carbohydrate binding module family 32 RNA_pol_Rpc4 PF05132.14 EFC46964.1 - 1.6 9.1 6.3 0.19 12.2 1.0 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF3408 PF11888.8 EFC46964.1 - 1.7 8.8 13.6 0.42 10.7 5.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) SR-25 PF10500.9 EFC46964.1 - 1.9 8.0 23.5 0.26 10.9 17.8 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4786 PF16027.5 EFC46964.1 - 2.8 8.5 9.1 0.28 11.8 4.3 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4786) Zip PF02535.22 EFC46964.1 - 3.6 6.7 11.7 14 4.8 6.7 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter PGA2 PF07543.12 EFC46964.1 - 3.6 7.5 16.4 2.1 8.3 10.7 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 EOS1 PF12326.8 EFC46964.1 - 4.8 7.1 8.7 0.14 12.1 1.6 1.9 2 1 0 2 2 2 0 N-glycosylation protein ANAPC15 PF15243.6 EFC46964.1 - 4.8 7.6 16.9 1.7 9.1 1.6 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 15 GP67 PF17634.2 EFC46964.1 - 4.9 7.6 12.3 1.6 9.2 4.3 2.4 2 0 0 2 2 2 0 Gene product 67 Connexin PF00029.19 EFC46964.1 - 5.6 6.7 8.9 0.17 11.6 0.8 2.3 2 1 0 2 2 2 0 Connexin Ank_2 PF12796.7 EFC46965.1 - 6.7e-18 65.1 4.0 7.2e-07 29.7 0.3 4.8 2 2 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC46965.1 - 3.2e-11 42.4 1.5 0.025 15.1 0.0 6.4 7 0 0 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EFC46965.1 - 5.1e-10 39.7 0.6 0.00069 20.1 0.0 5.1 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC46965.1 - 2.3e-07 30.9 6.8 0.0068 16.7 0.0 4.7 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC46965.1 - 8.9e-05 22.8 0.2 0.53 10.8 0.0 4.5 6 0 0 6 6 6 1 Ankyrin repeat Rab3-GTPase_cat PF13890.6 EFC46966.1 - 1.6e-34 118.9 1.3 3.9e-33 114.4 1.3 2.6 1 1 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit TFIIS_C PF01096.18 EFC46968.1 - 2.6e-18 65.6 7.5 3.8e-18 65.0 7.5 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) TFIIS_M PF07500.14 EFC46968.1 - 9.8e-11 42.1 2.2 4.1e-10 40.1 0.8 1.9 1 1 1 2 2 2 1 Transcription factor S-II (TFIIS), central domain Baculo_LEF5_C PF11792.8 EFC46968.1 - 0.068 12.9 1.7 0.086 12.5 0.6 1.8 1 1 1 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain C1_4 PF07975.12 EFC46968.1 - 0.19 12.0 4.8 0.27 11.5 1.8 2.4 1 1 1 2 2 2 0 TFIIH C1-like domain SYF2 PF08231.12 EFC46969.1 - 1.5e-05 25.5 21.8 1.5e-05 25.5 21.8 4.5 2 2 1 3 3 3 1 SYF2 splicing factor PilM PF07419.12 EFC46969.1 - 2.8 8.1 9.1 0.99 9.6 1.0 3.0 3 0 0 3 3 3 0 PilM Toxin_28 PF08115.11 EFC46969.1 - 3.3 7.6 0.0 3.3 7.6 0.0 3.7 4 1 1 5 5 5 0 SFI toxin family Ank_4 PF13637.6 EFC46970.1 - 0.00013 22.4 0.1 0.00027 21.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC46970.1 - 0.0009 19.8 0.1 0.0026 18.3 0.0 1.6 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC46970.1 - 0.19 12.4 0.2 0.82 10.4 0.1 2.1 2 0 0 2 2 2 0 Ankyrin repeat T3RM_EcoP15I_C PF18273.1 EFC46970.1 - 0.29 11.5 2.5 14 6.1 0.1 2.2 1 1 1 2 2 2 0 Type III R-M EcoP15I C-terminal domain Guanylate_cyc PF00211.20 EFC46972.1 - 4.3e-54 182.9 0.8 9.8e-54 181.8 0.1 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC46972.1 - 8.5e-13 48.5 0.0 2.5e-12 47.0 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC46972.1 - 8.3e-07 29.0 0.0 2.4e-06 27.5 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC46972.1 - 0.0045 17.0 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 PAS domain Acetyltransf_11 PF13720.6 EFC46972.1 - 0.034 14.6 0.7 0.28 11.7 0.5 2.7 2 1 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 PAS_4 PF08448.10 EFC46972.1 - 0.058 13.7 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 PAS fold DUF5638 PF18688.1 EFC46972.1 - 0.065 13.5 8.7 0.09 13.1 0.6 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5638) Pkinase PF00069.25 EFC46973.1 - 5.9e-23 81.6 1.0 9e-23 81.0 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC46973.1 - 3e-10 39.8 0.0 6.2e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC46974.1 - 6.3e-21 73.3 1.3 0.00019 21.3 0.0 6.5 6 0 0 6 6 6 5 NHL repeat BTB PF00651.31 EFC46974.1 - 7.3e-08 32.6 3.8 1.1e-07 32.0 0.2 2.5 2 0 0 2 2 2 1 BTB/POZ domain Linker_histone PF00538.19 EFC46974.1 - 6.8e-06 26.4 0.9 47 4.4 0.0 6.3 6 0 0 6 6 6 0 linker histone H1 and H5 family SGL PF08450.12 EFC46974.1 - 0.0064 16.1 0.0 0.094 12.3 0.0 2.4 3 0 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region PCMT PF01135.19 EFC46974.1 - 0.014 15.2 0.2 0.25 11.1 0.0 2.8 2 1 1 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Apo-CIII PF05778.12 EFC46975.1 - 0.11 12.1 0.0 0.67 9.6 0.0 2.2 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) CH PF00307.31 EFC46976.1 - 1.1e-08 35.1 0.3 1.4e-08 34.8 0.3 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 EFC46976.1 - 0.006 16.7 0.0 0.0091 16.1 0.0 1.3 1 0 0 1 1 1 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 EFC46976.1 - 0.0079 16.0 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain FA_hydroxylase PF04116.13 EFC46977.1 - 4.9e-20 72.2 14.2 4.9e-20 72.2 14.2 2.2 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily FA_hydroxylase PF04116.13 EFC46978.1 - 3.6e-20 72.7 14.0 3.6e-20 72.7 14.0 2.2 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily ASFV_J13L PF05568.11 EFC46978.1 - 0.34 10.7 2.1 0.56 9.9 2.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein zf-Tim10_DDP PF02953.15 EFC46979.1 - 9.1e-20 70.1 4.3 1.2e-19 69.7 4.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger PPR_2 PF13041.6 EFC46979.1 - 0.02 15.1 0.8 0.032 14.4 0.8 1.3 1 0 0 1 1 1 0 PPR repeat family PPR PF01535.20 EFC46979.1 - 0.027 14.7 2.0 0.029 14.6 0.8 1.7 2 0 0 2 2 2 0 PPR repeat OAM_alpha PF16552.5 EFC46979.1 - 0.029 14.2 0.0 0.036 13.9 0.0 1.0 1 0 0 1 1 1 0 D-ornithine 4,5-aminomutase alpha-subunit DUF4215 PF13948.6 EFC46979.1 - 0.035 14.5 0.4 0.066 13.6 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) EIF_2_alpha PF07541.12 EFC46979.1 - 0.087 12.9 0.5 0.1 12.7 0.5 1.3 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit PPR_1 PF12854.7 EFC46979.1 - 0.088 12.5 0.7 0.15 11.8 0.7 1.4 1 0 0 1 1 1 0 PPR repeat Metallophos PF00149.28 EFC46981.1 - 1.4e-10 42.0 0.6 1.8e-10 41.7 0.6 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC46981.1 - 5.8e-09 36.4 0.0 1.9e-08 34.7 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Ras PF00071.22 EFC46983.1 - 2.2e-21 76.1 0.5 2.9e-21 75.7 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46983.1 - 5e-17 62.2 0.0 1.1e-16 61.2 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC46983.1 - 2.7e-06 26.9 0.7 3.6e-06 26.5 0.7 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 EFC46983.1 - 0.00072 19.1 0.1 0.001 18.6 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family TniB PF05621.11 EFC46983.1 - 0.0015 18.0 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein MMR_HSR1 PF01926.23 EFC46983.1 - 0.0016 18.5 0.0 0.0025 17.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EFC46983.1 - 0.0056 16.4 0.1 0.0084 15.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EFC46983.1 - 0.009 15.6 0.0 0.016 14.8 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Lipase_GDSL_3 PF14606.6 EFC46983.1 - 0.0097 16.1 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family KTI12 PF08433.10 EFC46983.1 - 0.026 14.0 0.1 0.096 12.1 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 DUF2884 PF11101.8 EFC46983.1 - 0.028 13.9 0.0 0.93 9.0 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) Mg_chelatase PF01078.21 EFC46983.1 - 0.028 13.8 0.1 0.067 12.6 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI G-alpha PF00503.20 EFC46983.1 - 0.046 12.9 0.8 0.14 11.3 0.5 1.8 1 1 1 2 2 2 0 G-protein alpha subunit AAA_33 PF13671.6 EFC46983.1 - 0.11 12.7 0.2 0.25 11.5 0.0 1.8 2 1 0 2 2 2 0 AAA domain Bact_lectin PF18483.1 EFC46984.1 - 6.2e-23 81.8 0.2 1.3e-22 80.8 0.2 1.5 1 0 0 1 1 1 1 Bacterial lectin PUL PF08324.11 EFC46984.1 - 8.4e-22 77.7 3.2 1.4e-21 76.9 3.2 1.3 1 0 0 1 1 1 1 PUL domain Lectin_legB PF00139.19 EFC46984.1 - 3e-14 53.2 0.2 6.7e-14 52.0 0.2 1.5 1 0 0 1 1 1 1 Legume lectin domain Transglut_core PF01841.19 EFC46984.1 - 5.5e-12 46.1 0.5 1.2e-11 45.1 0.5 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily Rad4 PF03835.15 EFC46984.1 - 7.7e-08 32.1 2.4 2e-07 30.8 0.4 2.4 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain Lectin_leg-like PF03388.13 EFC46984.1 - 1.7e-07 30.9 0.1 4.4e-07 29.5 0.1 1.6 1 1 0 1 1 1 1 Legume-like lectin family PAW PF04721.17 EFC46984.1 - 0.0022 17.8 0.0 0.0048 16.7 0.0 1.6 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW LPP20 PF02169.16 EFC46985.1 - 1.4 9.3 0.0 1.4 9.3 0.0 3.2 4 0 0 4 4 4 0 LPP20 lipoprotein Arylesterase PF01731.20 EFC46986.1 - 2.5e-05 24.4 0.0 0.041 14.1 0.0 3.7 4 0 0 4 4 4 1 Arylesterase PQQ_2 PF13360.6 EFC46986.1 - 0.0081 15.8 0.0 0.015 14.9 0.0 1.5 1 1 0 1 1 1 1 PQQ-like domain DUF5128 PF17170.4 EFC46986.1 - 0.0088 15.2 0.3 0.37 9.9 0.0 2.3 2 1 0 2 2 2 1 6-bladed beta-propeller SGL PF08450.12 EFC46986.1 - 0.013 15.0 0.0 0.41 10.2 0.0 2.6 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PQQ PF01011.21 EFC46986.1 - 0.066 13.2 0.0 0.74 9.9 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat NHL PF01436.21 EFC46986.1 - 0.23 11.6 1.3 18 5.6 0.1 3.2 3 0 0 3 3 3 0 NHL repeat 2OG-FeII_Oxy_2 PF13532.6 EFC46987.1 - 1.6e-08 35.0 0.0 1.9e-06 28.2 0.0 2.0 1 1 1 2 2 2 2 2OG-Fe(II) oxygenase superfamily Ras PF00071.22 EFC46988.1 - 1.3e-33 115.9 0.0 2.1e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC46988.1 - 2.1e-15 57.0 0.0 4.7e-15 55.9 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC46988.1 - 0.0097 15.4 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box PF00646.33 EFC46988.1 - 0.014 15.2 0.3 0.042 13.8 0.3 1.8 1 0 0 1 1 1 0 F-box domain APG6_N PF17675.1 EFC46989.1 - 0.01 16.3 12.0 0.01 16.3 12.0 5.9 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF4023 PF13215.6 EFC46989.1 - 1.4 9.0 8.6 0.096 12.7 1.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4023) Dak2 PF02734.17 EFC46989.1 - 3.9 7.3 7.5 48 3.8 0.2 3.8 2 1 1 3 3 3 0 DAK2 domain VWA_2 PF13519.6 EFC46989.1 - 8.1 7.2 11.5 5.3 7.7 0.6 4.0 2 1 0 3 3 3 0 von Willebrand factor type A domain AATF-Che1 PF13339.6 EFC46990.1 - 0.36 11.5 6.7 0.038 14.7 1.8 1.9 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor LMBR1 PF04791.16 EFC46990.1 - 0.46 9.3 4.4 0.47 9.3 4.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Smg4_UPF3 PF03467.15 EFC46991.1 - 1.4e-18 67.5 0.1 1.4e-18 67.5 0.1 3.2 2 1 0 2 2 2 1 Smg-4/UPF3 family dsRBD2 PF17842.1 EFC46991.1 - 0.67 10.2 7.2 0.13 12.5 2.1 2.2 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 DUF4551 PF15087.6 EFC46991.1 - 6.3 5.5 15.9 10 4.8 15.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Med14 PF08638.11 EFC46992.1 - 1.6e-33 115.8 1.1 3.2e-33 114.8 1.1 1.5 1 0 0 1 1 1 1 Mediator complex subunit MED14 TLD PF07534.16 EFC46993.1 - 9.2e-19 68.0 3.6 9.2e-19 68.0 3.6 2.4 3 0 0 3 3 3 1 TLD Pentapeptide_4 PF13599.6 EFC46993.1 - 1.2e-08 34.9 34.3 1.1e-06 28.7 10.9 3.9 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 EFC46993.1 - 0.00019 21.5 22.9 0.28 11.4 6.0 4.3 3 1 1 4 4 4 3 Pentapeptide repeats (9 copies) BTB_2 PF02214.22 EFC46993.1 - 0.002 18.4 0.0 0.0063 16.8 0.0 1.9 1 0 0 1 1 1 1 BTB/POZ domain Pentapeptide PF00805.22 EFC46993.1 - 0.018 14.7 24.3 0.33 10.6 0.1 6.8 6 2 1 7 7 7 0 Pentapeptide repeats (8 copies) Toxin_TOLIP PF00087.21 EFC46994.1 - 0.067 13.4 6.2 0.088 13.1 5.9 1.4 1 1 0 1 1 1 0 Snake toxin and toxin-like protein MHC2-interact PF09307.10 EFC46994.1 - 0.3 11.1 1.3 0.43 10.6 1.3 1.3 1 0 0 1 1 1 0 CLIP, MHC2 interacting Activin_recp PF01064.23 EFC46994.1 - 0.64 11.2 6.0 2.2 9.4 6.0 1.9 1 1 0 1 1 1 0 Activin types I and II receptor domain UPAR_LY6 PF00021.21 EFC46994.1 - 0.69 10.6 7.0 1.7 9.4 7.0 1.6 1 1 0 1 1 1 0 u-PAR/Ly-6 domain F-box PF00646.33 EFC46995.1 - 0.00049 19.9 1.3 0.0018 18.1 1.3 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC46995.1 - 0.034 14.1 0.4 0.1 12.5 0.4 1.8 1 0 0 1 1 1 0 F-box-like IL7 PF01415.16 EFC46995.1 - 0.21 11.6 9.7 5.5 7.0 1.6 3.7 3 0 0 3 3 3 0 Interleukin 7/9 family F-box-like PF12937.7 EFC46996.1 - 0.0019 18.0 0.3 0.0057 16.5 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC46996.1 - 0.0059 16.5 0.0 0.021 14.7 0.0 2.0 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 EFC46996.1 - 0.046 13.5 5.0 3.9 7.3 0.1 4.5 4 1 1 6 6 6 0 Leucine rich repeat FAD_binding_7 PF03441.14 EFC46996.1 - 0.2 11.1 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain of DNA photolyase PPR_2 PF13041.6 EFC46997.1 - 6.7e-33 112.7 12.9 1.8e-11 44.1 0.0 10.7 7 3 4 11 11 10 8 PPR repeat family PPR PF01535.20 EFC46997.1 - 2.2e-32 109.0 22.7 0.00011 22.2 0.0 11.4 12 0 0 12 12 12 7 PPR repeat PPR_1 PF12854.7 EFC46997.1 - 2.1e-28 97.7 3.4 2.4e-08 33.5 0.0 7.6 7 0 0 7 7 7 5 PPR repeat PPR_3 PF13812.6 EFC46997.1 - 2.5e-17 62.7 9.5 4.2e-08 33.1 0.1 9.1 7 5 3 10 10 10 4 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC46997.1 - 1.4e-11 44.2 0.0 8.4e-06 25.3 0.0 4.4 1 1 3 4 4 4 3 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 EFC46997.1 - 4.2e-07 29.8 4.0 0.36 10.7 0.0 6.6 5 3 2 7 7 7 2 Mitochondrial ATPase expression TPR_19 PF14559.6 EFC46997.1 - 0.0028 18.1 0.0 3.3 8.3 0.0 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC46997.1 - 0.0033 17.7 0.6 6 7.2 0.0 4.6 5 0 0 5 5 5 1 Tetratricopeptide repeat PAZ_siRNAbind PF12212.8 EFC46997.1 - 0.016 15.0 4.6 1.4 8.8 0.1 3.1 3 0 0 3 3 3 0 PAZ domain SPOB_a PF14689.6 EFC46997.1 - 0.081 12.6 0.0 53 3.6 0.0 5.0 6 0 0 6 6 6 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_15 PF13429.6 EFC46997.1 - 0.13 11.5 0.0 0.75 9.0 0.0 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat CH PF00307.31 EFC46997.1 - 0.26 11.5 3.0 4 7.7 0.1 3.8 4 0 0 4 4 4 0 Calponin homology (CH) domain TPR_1 PF00515.28 EFC46997.1 - 8.8 6.3 6.7 16 5.5 1.5 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Acetyltransf_9 PF13527.7 EFC46998.1 - 0.064 13.3 0.1 0.22 11.6 0.0 1.8 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain DUF2263 PF10021.9 EFC46999.1 - 2.5e-26 92.8 0.0 4.3e-26 92.0 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Amidinotransf PF02274.17 EFC47000.1 - 1e-50 172.8 0.1 1.7e-50 172.0 0.1 1.4 1 0 0 1 1 1 1 Amidinotransferase PAD_porph PF04371.15 EFC47000.1 - 0.023 14.0 0.0 0.052 12.8 0.0 1.6 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase Seryl_tRNA_N PF02403.22 EFC47000.1 - 1.3 9.3 5.6 2.2 8.6 0.1 3.1 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain MSC PF09402.10 EFC47001.1 - 3.1e-14 53.2 7.0 3.1e-14 53.2 7.0 2.6 2 1 0 2 2 2 1 Man1-Src1p-C-terminal domain Thymopoietin PF08198.11 EFC47001.1 - 5.3e-10 38.7 0.6 1.1e-09 37.7 0.6 1.5 1 0 0 1 1 1 1 Thymopoietin protein HeH PF12949.7 EFC47001.1 - 9.9e-08 31.6 0.5 2.3e-07 30.4 0.1 1.8 2 0 0 2 2 2 1 HeH/LEM domain DUF2659 PF10858.8 EFC47001.1 - 0.052 13.2 0.1 0.093 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2659) SKI PF01202.22 EFC47002.1 - 1e-25 90.7 0.0 1.9e-25 89.9 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase Thr_synth_N PF14821.6 EFC47002.1 - 8.3e-19 67.6 0.0 3.8e-18 65.5 0.0 2.1 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 EFC47002.1 - 2.5e-05 23.9 0.0 4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme AAA_18 PF13238.6 EFC47002.1 - 8.8e-05 23.1 0.0 0.0002 21.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFC47002.1 - 0.0009 19.7 0.0 0.0028 18.1 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC47002.1 - 0.0029 17.9 0.0 0.0097 16.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC47002.1 - 0.008 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 EFC47002.1 - 0.0091 16.4 0.1 0.092 13.2 0.0 2.5 2 1 0 2 2 1 1 AAA domain Rad17 PF03215.15 EFC47002.1 - 0.011 15.7 0.0 0.054 13.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain RuvB_N PF05496.12 EFC47002.1 - 0.02 14.6 0.0 0.044 13.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC47002.1 - 0.02 14.9 0.1 0.055 13.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFC47002.1 - 0.03 13.7 0.0 0.081 12.3 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 EFC47002.1 - 0.076 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 EFC47002.1 - 0.087 12.9 0.1 6.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Adenylate kinase CysG_dimeriser PF10414.9 EFC47002.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region ABC_tran PF00005.27 EFC47002.1 - 0.16 12.4 0.0 0.37 11.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RGS12_us1 PF16613.5 EFC47003.1 - 0.11 12.9 3.4 0.2 12.0 3.4 1.4 1 0 0 1 1 1 0 Unstructured region of RGS12 PepSY_TM PF03929.16 EFC47005.1 - 0.14 11.9 1.8 0.21 11.2 0.9 1.7 2 0 0 2 2 2 0 PepSY-associated TM region DUF4328 PF14219.6 EFC47005.1 - 0.15 11.6 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4328) F-box PF00646.33 EFC47006.1 - 0.0016 18.3 1.3 0.0048 16.7 1.4 1.9 1 1 1 2 2 2 1 F-box domain F-box-like PF12937.7 EFC47006.1 - 0.0036 17.1 0.2 0.0059 16.5 0.2 1.4 1 0 0 1 1 1 1 F-box-like MutS_IV PF05190.18 EFC47006.1 - 0.076 13.4 0.6 4 7.9 0.2 2.1 2 0 0 2 2 2 0 MutS family domain IV DUF1664 PF07889.12 EFC47006.1 - 0.12 12.5 0.2 8 6.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 EFC47006.1 - 0.16 12.3 3.6 2.2 8.6 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) FAD_binding_3 PF01494.19 EFC47007.1 - 5.7e-06 25.8 0.0 0.07 12.4 0.0 2.4 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 EFC47007.1 - 0.00018 21.2 0.0 0.0017 18.0 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 EFC47007.1 - 0.0015 17.8 0.0 0.0029 16.9 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 EFC47007.1 - 0.0052 16.1 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC47007.1 - 0.015 14.0 0.0 0.035 12.8 0.0 1.6 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 EFC47007.1 - 0.032 14.5 0.0 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 EFC47007.1 - 0.045 13.0 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC47007.1 - 0.056 12.5 0.0 0.11 11.5 0.0 1.5 2 0 0 2 2 2 0 Lycopene cyclase protein LolA_2 PF16584.5 EFC47008.1 - 0.022 14.6 0.1 0.043 13.7 0.1 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA FtsX PF02687.21 EFC47009.1 - 2.3e-16 60.1 22.7 4.6e-11 43.0 5.7 7.2 6 1 2 8 8 8 4 FtsX-like permease family ELFV_dehydrog_N PF02812.18 EFC47011.1 - 0.00073 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NatB_MDM20 PF09797.9 EFC47011.1 - 0.014 14.3 0.1 0.023 13.6 0.1 1.2 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit ELFV_dehydrog PF00208.21 EFC47011.1 - 0.14 11.8 0.3 3.7 7.2 0.3 2.5 1 1 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase F-box PF00646.33 EFC47012.1 - 1.2e-08 34.6 0.0 3.1e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC47012.1 - 1.3e-07 31.4 0.1 2.3e-07 30.6 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 EFC47012.1 - 0.023 14.6 0.4 0.063 13.2 0.0 1.9 2 1 0 2 2 2 0 F-box Dabb PF07876.12 EFC47012.1 - 0.025 15.2 0.0 0.059 14.0 0.0 1.6 1 1 0 1 1 1 0 Stress responsive A/B Barrel Domain LRR_6 PF13516.6 EFC47014.1 - 2.3e-44 145.7 4.6 3.4e-06 26.6 0.0 7.5 7 0 0 7 7 7 7 Leucine Rich repeat LRR_8 PF13855.6 EFC47014.1 - 5e-22 77.4 3.3 3e-07 30.1 0.0 4.2 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC47014.1 - 1.5e-21 76.1 3.8 1.3e-05 25.4 0.0 5.2 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47014.1 - 2.4e-16 57.7 0.1 2 9.3 0.0 7.4 7 1 0 7 7 7 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC47014.1 - 0.00038 20.0 0.1 0.076 12.5 0.1 2.6 1 1 2 3 3 3 1 Leucine-rich repeat ApoB100_C PF12491.8 EFC47014.1 - 0.0024 17.8 8.6 0.78 9.7 0.1 5.9 2 2 4 6 6 6 1 Apolipoprotein B100 C terminal DUF5490 PF17593.2 EFC47014.1 - 0.0028 17.6 0.1 31 4.7 0.0 5.0 3 2 3 6 6 6 0 Family of unknown function (DUF5490) Spidroin_N PF16763.5 EFC47014.1 - 0.0031 17.5 1.4 13 5.8 0.0 4.2 2 2 3 5 5 5 1 Major ampullate spidroin 1, spider silk protein 1, N-term DUF424 PF04242.13 EFC47014.1 - 0.0068 16.6 1.3 5.5 7.3 0.1 3.6 1 1 1 3 3 3 1 Protein of unknown function (DUF424) Beta_helix PF13229.6 EFC47014.1 - 0.015 15.1 1.5 0.082 12.7 1.2 2.0 1 1 0 1 1 1 0 Right handed beta helix region Chibby PF14645.6 EFC47014.1 - 0.046 14.1 0.1 0.35 11.3 0.0 2.2 1 1 0 2 2 2 0 Chibby family NHL PF01436.21 EFC47015.1 - 8e-16 57.2 2.1 3.2e-06 26.9 0.0 5.0 5 0 0 5 5 5 4 NHL repeat Arylesterase PF01731.20 EFC47015.1 - 0.011 15.9 0.2 2.1 8.6 0.1 3.4 3 1 0 3 3 3 0 Arylesterase SGL PF08450.12 EFC47015.1 - 0.019 14.6 0.0 0.54 9.8 0.0 2.6 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region LRR_6 PF13516.6 EFC47016.1 - 1.3e-26 90.4 26.5 0.0013 18.6 0.0 10.7 11 0 0 11 11 11 7 Leucine Rich repeat LRR_8 PF13855.6 EFC47016.1 - 1.9e-20 72.3 19.7 1.5e-07 31.1 0.6 4.6 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC47016.1 - 1.1e-19 70.2 26.8 9e-06 25.9 0.7 6.7 3 2 2 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC47016.1 - 6.4e-08 32.3 8.9 9.4e-05 22.0 0.4 2.6 1 1 0 2 2 2 2 Leucine-rich repeat LRR_5 PF13306.6 EFC47016.1 - 0.0002 21.3 3.1 0.051 13.5 0.0 3.1 2 1 0 2 2 2 1 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 EFC47016.1 - 0.00028 21.0 17.1 34 5.6 0.2 9.3 10 1 0 10 10 10 0 Leucine Rich Repeat Ras PF00071.22 EFC47019.1 - 1.9e-47 160.9 0.0 4.3e-47 159.7 0.0 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC47019.1 - 7.9e-19 68.0 0.0 1.9e-18 66.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47019.1 - 3e-10 39.8 0.0 5.8e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC47019.1 - 0.032 14.3 0.0 0.18 11.9 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 EFC47019.1 - 0.056 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_21 PF13304.6 EFC47019.1 - 1.4 8.7 4.6 15 5.2 0.1 2.5 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF4116 PF13475.6 EFC47020.1 - 1.9e-41 139.5 1.8 4.2e-10 39.2 0.0 6.9 5 1 1 7 7 7 6 Domain of unknown function (DUF4116) F-box PF00646.33 EFC47021.1 - 0.0018 18.1 0.1 0.0052 16.6 0.1 1.8 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 EFC47021.1 - 0.0047 16.8 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 F-box HSP20 PF00011.21 EFC47022.1 - 1.3e-14 54.2 1.3 1.9e-14 53.7 1.3 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC47022.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.4 1 1 0 1 1 1 0 HSP20-like domain found in ArsA Pkinase PF00069.25 EFC47023.1 - 3.3e-50 170.9 0.5 3.7e-50 170.7 0.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47023.1 - 4.2e-39 134.4 0.2 4.6e-39 134.3 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC47023.1 - 4.3e-06 25.8 0.4 6.2e-06 25.2 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC47023.1 - 0.00015 21.2 0.0 0.0002 20.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 EFC47023.1 - 0.0017 17.9 0.1 0.0061 16.1 0.0 1.8 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 EFC47023.1 - 0.0021 17.1 0.2 0.0025 16.8 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC47023.1 - 0.0033 16.8 1.0 0.0044 16.4 0.4 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC47023.1 - 0.027 14.4 0.1 0.054 13.4 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 EFC47023.1 - 0.041 13.5 0.4 0.23 11.0 0.0 1.9 2 0 0 2 2 2 0 RIO1 family PKcGMP_CC PF16808.5 EFC47024.1 - 0.11 12.3 1.4 0.11 12.3 1.4 1.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF456 PF04306.13 EFC47025.1 - 0.022 15.1 1.6 0.022 15.1 1.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF456) G-alpha PF00503.20 EFC47026.1 - 5.6e-22 78.4 0.9 6.1e-22 78.3 0.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit AtuA PF07287.11 EFC47027.1 - 6.3e-126 419.8 0.0 7.8e-126 419.5 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA LPD39 PF18858.1 EFC47028.1 - 0.029 14.5 1.0 0.035 14.2 0.1 1.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 39 PulA_N1 PF17999.1 EFC47028.1 - 0.048 14.4 1.4 0.13 13.0 0.3 2.3 2 0 0 2 2 2 0 Pullulanase N1-terminal domain LMP PF04778.12 EFC47028.1 - 2.1 8.2 8.1 0.12 12.3 1.8 2.1 2 1 1 3 3 3 0 LMP repeated region NHL PF01436.21 EFC47030.1 - 1.3e-13 50.2 2.6 8.3e-05 22.4 0.0 5.7 5 0 0 5 5 5 3 NHL repeat Lactonase PF10282.9 EFC47030.1 - 0.097 11.9 0.0 8.1 5.6 0.0 2.5 2 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller KRTAP PF11759.8 EFC47031.1 - 5.7e-05 23.6 76.2 1.8e+04 -35.1 76.2 3.9 1 1 0 1 1 1 0 Keratin-associated matrix Keratin_2_head PF16208.5 EFC47031.1 - 0.022 14.9 73.6 1.8e+04 -35.4 73.6 4.2 1 1 0 1 1 1 0 Keratin type II head TPR_2 PF07719.17 EFC47032.1 - 1.6e-15 55.9 27.4 0.00069 19.5 0.3 9.1 10 0 0 10 10 9 4 Tetratricopeptide repeat Cadherin_3 PF16184.5 EFC47032.1 - 2.9e-09 36.9 0.5 5.9e-09 35.9 0.5 1.5 1 0 0 1 1 1 1 Cadherin-like TPR_17 PF13431.6 EFC47032.1 - 1.7e-08 34.3 4.2 3.4e-05 23.9 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC47032.1 - 2.2e-08 34.1 0.2 0.021 15.0 0.0 3.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47032.1 - 1.8e-06 27.5 39.2 0.0077 16.0 0.8 9.0 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47032.1 - 3.9e-05 24.1 3.4 5.9 7.5 0.0 5.2 4 1 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47032.1 - 8.6e-05 22.8 20.4 0.0015 18.8 0.0 6.6 7 2 1 8 8 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC47032.1 - 0.00032 21.3 1.4 6.4 7.9 0.0 5.7 5 2 3 8 8 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47032.1 - 0.00065 19.6 15.7 0.021 14.8 0.2 6.4 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47032.1 - 0.0016 18.5 37.1 0.37 11.1 0.1 9.5 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_6 PF13174.6 EFC47032.1 - 0.0016 18.9 8.5 0.85 10.4 0.1 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47032.1 - 0.0097 16.5 0.4 1.5 9.6 0.0 3.8 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFC47032.1 - 0.043 13.0 4.7 1.2 8.3 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC47032.1 - 0.16 11.4 0.0 2 7.7 0.0 2.5 3 0 0 3 3 3 0 MalT-like TPR region ANAPC5 PF12862.7 EFC47032.1 - 0.18 11.9 8.3 2.2 8.4 0.3 3.9 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 5 Pep3_Vps18 PF05131.14 EFC47032.1 - 0.31 10.9 3.4 0.74 9.6 0.4 3.1 4 0 0 4 4 4 0 Pep3/Vps18/deep orange family TPR_10 PF13374.6 EFC47032.1 - 1.2 9.1 14.2 3.4 7.7 0.3 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47032.1 - 1.6 8.5 6.7 1.8 8.3 0.0 4.3 6 0 0 6 6 6 0 TPR repeat Cnn_1N PF07989.11 EFC47032.1 - 1.8 8.8 5.9 25 5.1 0.0 2.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 RPN7 PF10602.9 EFC47032.1 - 7.6 6.2 15.3 6.3 6.5 2.3 4.6 4 1 0 4 4 4 0 26S proteasome subunit RPN7 Nrf1_DNA-bind PF10491.9 EFC47033.1 - 0.027 14.2 0.7 1.4 8.6 0.0 2.2 2 0 0 2 2 2 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Trypsin PF00089.26 EFC47033.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Trypsin DUF4487 PF14868.6 EFC47035.1 - 0.00057 18.9 0.1 0.0009 18.2 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4487) G-alpha PF00503.20 EFC47036.1 - 1.7e-29 103.1 6.2 3.1e-29 102.3 6.2 1.4 1 0 0 1 1 1 1 G-protein alpha subunit Sulf_transp PF04143.14 EFC47037.1 - 3.8e-10 39.8 25.0 1.2e-06 28.4 7.8 3.2 3 0 0 3 3 3 3 Sulphur transport TFB6 PF17110.5 EFC47038.1 - 0.073 12.8 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SurA_N PF09312.11 EFC47038.1 - 0.083 13.0 0.9 0.15 12.2 0.8 1.4 1 1 0 1 1 1 0 SurA N-terminal domain Ras PF00071.22 EFC47039.1 - 7.4e-22 77.7 0.0 8.6e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47039.1 - 0.00029 21.0 0.0 0.00047 20.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47039.1 - 0.012 15.1 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family Phosphodiest PF01663.22 EFC47040.1 - 3.9e-84 283.3 0.1 4.5e-84 283.1 0.1 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFC47040.1 - 0.00034 20.1 0.0 0.0015 18.0 0.0 2.0 1 1 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EFC47040.1 - 0.00083 18.8 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily CLP1_P PF16575.5 EFC47041.1 - 2.7e-26 92.5 0.2 6.2e-26 91.3 0.2 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop TPR_1 PF00515.28 EFC47041.1 - 9.5e-09 34.7 0.9 0.16 11.8 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47041.1 - 3.7e-08 32.9 0.2 0.016 15.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC47041.1 - 0.00023 21.2 0.1 0.013 15.6 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47041.1 - 0.0013 18.4 0.2 0.46 10.2 0.2 2.8 2 1 1 3 3 3 1 TPR repeat TPR_16 PF13432.6 EFC47041.1 - 0.0019 18.8 0.0 0.4 11.4 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47041.1 - 0.011 16.2 0.1 0.038 14.5 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat GTP_EFTU PF00009.27 EFC47041.1 - 0.032 13.8 0.1 0.42 10.1 0.1 2.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain TPR_12 PF13424.6 EFC47041.1 - 0.064 13.6 0.0 2.2 8.6 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Tex_N PF09371.10 EFC47041.1 - 0.11 12.2 1.6 0.16 11.6 0.1 1.9 2 0 0 2 2 2 0 Tex-like protein N-terminal domain Fis1_TPR_C PF14853.6 EFC47041.1 - 0.13 12.4 1.6 0.71 10.0 0.4 2.4 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EFC47041.1 - 0.16 12.2 0.7 14 6.0 0.0 3.0 2 1 2 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 FGGY_N PF00370.21 EFC47042.1 - 1.3e-18 67.5 0.1 8.1e-15 55.0 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Integrin_beta PF00362.18 EFC47042.1 - 0.059 13.0 0.1 0.095 12.3 0.1 1.3 1 0 0 1 1 1 0 Integrin beta chain VWA domain DpnI_C PF17726.1 EFC47042.1 - 0.073 13.2 0.0 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Dam-replacing HTH domain ZipA_C PF04354.13 EFC47043.1 - 0.0058 16.5 1.0 2.1 8.2 0.2 2.4 1 1 1 2 2 2 2 ZipA, C-terminal FtsZ-binding domain Phospholamban PF04272.14 EFC47043.1 - 0.15 11.5 3.2 13 5.3 0.0 3.7 3 1 1 4 4 4 0 Phospholamban V-ATPase_G_2 PF16999.5 EFC47043.1 - 0.19 12.2 28.4 3.1 8.3 1.5 4.1 1 1 3 4 4 4 0 Vacuolar (H+)-ATPase G subunit PIN_12 PF16289.5 EFC47043.1 - 0.19 12.2 13.4 0.25 11.8 13.4 1.1 1 0 0 1 1 1 0 PIN domain MG3 PF17791.1 EFC47043.1 - 0.47 10.8 8.5 72 3.8 8.5 2.1 1 1 0 1 1 1 0 Macroglobulin domain MG3 Exonuc_VII_L PF02601.15 EFC47043.1 - 1.4 8.4 15.4 1.7 8.2 15.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Glyco_hydro_2 PF00703.21 EFC47043.1 - 1.4 9.6 18.1 4.4 8.0 6.6 2.2 1 1 1 2 2 2 0 Glycosyl hydrolases family 2 Vps51 PF08700.11 EFC47043.1 - 1.8 8.7 18.5 2 8.5 1.8 3.6 1 1 3 4 4 4 0 Vps51/Vps67 DUF2147 PF09917.9 EFC47043.1 - 5 7.8 8.8 0.64 10.7 2.3 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) DUF3886 PF13025.6 EFC47043.1 - 8.3 6.7 38.3 9.7 6.5 8.7 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF3886) CPL PF08144.11 EFC47044.1 - 1.4e-10 41.6 3.1 1.8e-07 31.6 0.1 4.1 4 0 0 4 4 4 2 CPL (NUC119) domain CorA PF01544.18 EFC47045.1 - 6.3e-48 163.6 0.6 7.5e-48 163.3 0.6 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Epimerase PF01370.21 EFC47046.1 - 1.8e-13 50.5 0.1 2.2e-11 43.7 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 EFC47046.1 - 4.5e-10 39.5 0.1 9.2e-10 38.5 0.1 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC47046.1 - 5.3e-10 39.5 0.3 9.8e-10 38.6 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 EFC47046.1 - 1.6e-06 27.3 1.0 9.4e-05 21.6 1.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 EFC47046.1 - 0.00032 19.9 0.0 0.3 10.2 0.0 2.6 2 1 0 2 2 2 2 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EFC47046.1 - 0.0024 18.1 0.6 0.036 14.3 0.1 2.8 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 EFC47046.1 - 0.0062 16.0 0.0 0.011 15.2 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC47046.1 - 0.071 12.2 0.0 0.12 11.5 0.0 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein ApbA PF02558.16 EFC47046.1 - 0.15 11.7 0.0 0.55 9.9 0.0 1.9 1 1 1 2 2 2 0 Ketopantoate reductase PanE/ApbA LRR_6 PF13516.6 EFC47047.1 - 6.2e-43 141.2 28.2 0.00032 20.5 0.0 11.8 11 1 1 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC47047.1 - 2.4e-26 91.2 24.1 9.8e-09 34.9 4.4 4.5 4 0 0 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC47047.1 - 3.3e-24 84.6 27.8 3.5e-05 24.1 1.8 6.2 3 2 0 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47047.1 - 1.3e-14 52.4 12.1 4.2 8.3 0.0 10.1 10 0 0 10 10 10 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC47047.1 - 2.3e-06 27.2 7.0 0.0055 16.2 0.5 3.1 1 1 2 3 3 3 3 Leucine-rich repeat LRR_5 PF13306.6 EFC47047.1 - 6.1e-06 26.2 10.8 0.044 13.7 0.3 3.4 1 1 2 3 3 3 3 BspA type Leucine rich repeat region (6 copies) DUF424 PF04242.13 EFC47047.1 - 0.02 15.2 1.9 0.07 13.4 0.1 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF424) Guanylate_cyc PF00211.20 EFC47048.1 - 1.1e-31 109.9 0.0 1.9e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain MreB_Mbl PF06723.13 EFC47048.1 - 0.11 11.3 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein HAMP PF00672.25 EFC47048.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 HAMP domain CENP-T_C PF15511.6 EFC47049.1 - 6.1e-08 32.8 0.0 7.6e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 EFC47049.1 - 5.2e-05 23.6 0.1 5.8e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 EFC47049.1 - 0.00039 20.5 0.0 0.00055 20.1 0.0 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFC47049.1 - 0.00087 19.5 0.0 0.0012 19.0 0.0 1.3 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 EFC47049.1 - 0.0013 19.1 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein Bromo_TP PF07524.13 EFC47049.1 - 0.0054 16.7 0.0 0.03 14.3 0.0 1.8 1 1 1 2 2 2 1 Bromodomain associated TFIID-31kDa PF02291.15 EFC47049.1 - 0.0082 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit F-box-like PF12937.7 EFC47051.1 - 0.041 13.8 0.4 0.074 13.0 0.4 1.5 1 0 0 1 1 1 0 F-box-like F-box-like_2 PF13013.6 EFC47051.1 - 0.054 13.5 3.4 0.051 13.5 0.9 2.2 2 1 0 2 2 2 0 F-box-like domain HAD_2 PF13419.6 EFC47052.1 - 1.1e-08 35.4 0.0 2e-08 34.6 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFC47052.1 - 3.7e-05 24.1 0.0 5.2e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase 5_nucleotid PF05761.14 EFC47052.1 - 0.0051 15.8 0.0 0.0076 15.2 0.0 1.2 1 0 0 1 1 1 1 5' nucleotidase family HH_signal PF01085.18 EFC47052.1 - 0.026 14.2 0.0 3 7.5 0.0 2.1 2 0 0 2 2 2 0 Hedgehog amino-terminal signalling domain Lyase_N PF09092.11 EFC47052.1 - 0.16 11.8 0.1 1.1 9.2 0.0 2.0 2 0 0 2 2 2 0 Lyase, N terminal NDUFA12 PF05071.16 EFC47053.1 - 1e-17 64.7 1.1 1.6e-17 64.1 1.1 1.5 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 NPV_P10 PF05531.12 EFC47054.1 - 0.031 14.7 2.2 0.18 12.3 2.0 2.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Exonuc_VII_S PF02609.16 EFC47054.1 - 0.032 14.3 0.7 0.051 13.6 0.7 1.3 1 0 0 1 1 1 0 Exonuclease VII small subunit XhlA PF10779.9 EFC47054.1 - 0.044 14.0 2.5 0.044 14.0 2.5 2.2 1 1 1 2 2 2 0 Haemolysin XhlA DUF1068 PF06364.12 EFC47054.1 - 0.073 12.9 0.8 0.085 12.7 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1068) Nup88 PF10168.9 EFC47054.1 - 0.098 10.5 2.7 0.11 10.2 2.7 1.0 1 0 0 1 1 1 0 Nuclear pore component BRCC36_C PF18110.1 EFC47054.1 - 0.12 12.6 0.6 0.23 11.6 0.5 1.5 1 1 0 1 1 1 0 BRCC36 C-terminal helical domain V-SNARE_C PF12352.8 EFC47054.1 - 0.14 12.5 0.4 0.14 12.5 0.4 1.7 2 1 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus DUF1664 PF07889.12 EFC47054.1 - 0.14 12.2 2.6 0.17 11.9 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 EFC47054.1 - 0.85 8.8 5.0 1 8.5 5.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein Sec20 PF03908.13 EFC47054.1 - 2.1 8.3 6.5 1.9 8.4 1.0 2.2 1 1 0 2 2 2 0 Sec20 Aminotran_3 PF00202.21 EFC47055.1 - 1e-123 413.0 0.0 1.2e-123 412.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 EFC47055.1 - 0.011 15.1 0.0 0.024 13.9 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Aminotran_1_2 PF00155.21 EFC47055.1 - 0.05 12.8 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II RhoGAP PF00620.27 EFC47056.1 - 1.3e-29 103.0 0.4 4.1e-29 101.4 0.4 1.9 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 EFC47056.1 - 1.5e-12 47.9 2.3 1.5e-12 47.9 2.3 2.2 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 EFC47056.1 - 0.0048 17.3 2.3 0.061 13.7 2.3 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 EFC47056.1 - 0.0085 16.4 2.6 0.029 14.6 2.6 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 EFC47056.1 - 0.018 14.9 1.5 0.042 13.7 1.5 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PH_15 PF17339.2 EFC47056.1 - 0.021 14.7 0.3 0.047 13.6 0.3 1.7 1 0 0 1 1 1 0 PH domain PH_11 PF15413.6 EFC47056.1 - 0.076 13.4 3.1 0.45 11.0 3.1 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain PhetRS_B1 PF18262.1 EFC47056.1 - 0.12 12.7 0.5 1.2 9.4 0.1 2.7 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain PH_3 PF14593.6 EFC47056.1 - 0.13 12.4 4.5 0.54 10.4 4.5 2.2 1 1 0 1 1 1 0 PH domain ThiF PF00899.21 EFC47057.1 - 1.7e-64 217.5 0.0 3.2e-64 216.6 0.0 1.4 1 1 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 EFC47057.1 - 2.8e-18 66.3 2.9 2.8e-18 66.3 2.9 2.1 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 EFC47057.1 - 3e-09 37.2 5.4 5.2e-07 29.9 0.2 3.0 2 1 1 3 3 3 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 EFC47057.1 - 0.0036 17.7 5.1 0.0071 16.8 0.0 3.2 3 1 0 3 3 3 1 Putative NAD(P)-binding Cor1 PF04803.12 EFC47057.1 - 0.0071 16.6 1.1 0.0071 16.6 1.1 2.6 3 0 0 3 3 3 1 Cor1/Xlr/Xmr conserved region Sacchrp_dh_NADP PF03435.18 EFC47057.1 - 0.017 15.4 0.4 0.32 11.2 0.4 2.7 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFC47057.1 - 0.02 15.0 0.0 0.057 13.5 0.0 1.8 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 EFC47057.1 - 0.41 11.2 2.2 1 10.0 0.3 2.6 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Vfa1 PF08432.10 EFC47057.1 - 0.47 10.8 4.5 1.2 9.4 4.5 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ATP_bind_1 PF03029.17 EFC47059.1 - 4.5e-82 275.5 0.0 5.4e-82 275.2 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 EFC47059.1 - 0.00012 21.1 0.0 0.00068 18.7 0.0 1.9 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 EFC47059.1 - 0.001 18.6 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 EFC47059.1 - 0.0084 16.6 0.1 0.048 14.2 0.0 2.2 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 EFC47059.1 - 0.0098 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_33 PF13671.6 EFC47059.1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 EFC47059.1 - 0.014 15.4 1.5 0.18 11.7 0.2 2.5 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFC47059.1 - 0.017 15.5 0.2 0.1 13.0 0.0 2.4 3 0 0 3 3 3 0 RNA helicase CLP1_P PF16575.5 EFC47059.1 - 0.025 14.4 0.0 0.06 13.1 0.0 1.7 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_22 PF13401.6 EFC47059.1 - 0.025 14.8 0.0 0.053 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EFC47059.1 - 0.031 14.7 0.9 0.22 12.0 0.3 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 EFC47059.1 - 0.039 13.7 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 EFC47059.1 - 0.081 13.0 0.0 0.13 12.3 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.7 EFC47059.1 - 0.09 11.7 0.1 0.32 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA-like domain ATPase PF06745.13 EFC47059.1 - 0.1 11.9 0.0 4 6.7 0.0 2.2 2 0 0 2 2 2 0 KaiC Pkinase PF00069.25 EFC47060.1 - 5.6e-34 117.7 0.0 9e-34 117.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47060.1 - 8.1e-26 90.8 0.0 1.3e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC47060.1 - 1.2e-14 53.5 19.3 0.0073 16.3 0.0 11.2 11 0 0 11 11 11 3 NHL repeat EGF_2 PF07974.13 EFC47060.1 - 1.2e-06 28.7 51.8 0.0034 17.7 10.5 4.5 4 0 0 4 4 4 3 EGF-like domain SGL PF08450.12 EFC47060.1 - 1.7e-05 24.5 3.1 0.0021 17.7 0.1 4.7 4 2 2 6 6 6 1 SMP-30/Gluconolactonase/LRE-like region Haspin_kinase PF12330.8 EFC47060.1 - 0.00069 18.7 0.1 0.0013 17.8 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Arylesterase PF01731.20 EFC47060.1 - 0.0041 17.3 10.9 0.0045 17.2 0.1 5.1 5 0 0 5 5 5 1 Arylesterase Jiraiya PF15038.6 EFC47060.1 - 0.1 12.0 0.2 1.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Jiraiya APH PF01636.23 EFC47060.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family EGF PF00008.27 EFC47060.1 - 0.42 11.0 33.3 0.054 13.8 3.8 4.1 4 0 0 4 4 4 0 EGF-like domain hEGF PF12661.7 EFC47060.1 - 6.2 7.6 40.6 1.1 10.0 4.2 4.8 4 0 0 4 4 4 0 Human growth factor-like EGF NAD_binding_10 PF13460.6 EFC47061.1 - 1.2e-26 93.8 0.0 1.4e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 EFC47061.1 - 0.00039 19.9 0.0 0.00078 18.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.18 EFC47061.1 - 0.038 14.3 0.0 0.058 13.6 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain NmrA PF05368.13 EFC47061.1 - 0.094 12.3 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family Pkinase PF00069.25 EFC47062.1 - 1.7e-26 93.2 0.1 1.8e-26 93.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47062.1 - 1e-15 57.8 0.0 1.1e-15 57.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC47062.1 - 0.0021 16.9 0.1 0.0021 16.9 0.1 1.0 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFC47062.1 - 0.0073 15.3 0.7 0.019 14.0 0.2 1.7 1 1 1 2 2 2 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 EFC47062.1 - 0.0077 15.6 0.1 0.009 15.4 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC47062.1 - 0.018 15.0 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC47062.1 - 0.021 13.8 0.0 0.022 13.7 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 EFC47062.1 - 0.033 13.8 0.0 0.034 13.7 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.6 EFC47062.1 - 0.077 12.3 0.0 0.087 12.1 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Radial_spoke_3 PF06098.11 EFC47065.1 - 1.9e-95 319.4 30.6 2.2e-95 319.2 30.6 1.0 1 0 0 1 1 1 1 Radial spoke protein 3 KIF1B PF12423.8 EFC47065.1 - 0.024 15.1 1.7 1.5 9.3 0.1 2.9 2 0 0 2 2 2 0 Kinesin protein 1B ARGLU PF15346.6 EFC47065.1 - 1.2 9.0 43.4 0.54 10.1 21.4 2.6 3 0 0 3 3 3 0 Arginine and glutamate-rich 1 DUF4407 PF14362.6 EFC47065.1 - 7.6 5.8 16.6 0.21 10.9 7.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Ribosomal_L6 PF00347.23 EFC47066.1 - 2.8e-23 82.4 7.4 4e-12 46.6 2.7 2.4 2 1 0 2 2 2 2 Ribosomal protein L6 Nse4_C PF08743.10 EFC47067.1 - 2e-17 63.2 0.1 2e-17 63.2 0.1 3.0 3 0 0 3 3 3 1 Nse4 C-terminal PPTA PF01239.22 EFC47068.1 - 1.2e-35 120.2 21.1 3e-08 33.1 0.6 6.0 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat LRR_4 PF12799.7 EFC47068.1 - 4.5e-09 36.4 20.6 3.5e-06 27.2 6.4 3.4 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47068.1 - 7.4e-05 22.4 11.5 0.00035 20.3 11.3 2.3 1 1 1 2 2 2 2 Leucine rich repeat LRR_9 PF14580.6 EFC47068.1 - 0.0034 16.9 7.1 0.038 13.5 7.1 2.5 1 1 0 1 1 1 1 Leucine-rich repeat LRR_1 PF00560.33 EFC47068.1 - 0.97 10.2 8.2 6.4 7.7 0.3 4.4 2 1 0 2 2 2 0 Leucine Rich Repeat BTB PF00651.31 EFC47069.1 - 7e-14 52.0 0.0 2.2e-10 40.7 0.1 2.5 2 0 0 2 2 2 2 BTB/POZ domain Ank_3 PF13606.6 EFC47069.1 - 0.0099 16.3 0.3 0.073 13.7 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 EFC47069.1 - 0.028 14.9 0.3 2.2 8.8 0.2 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_2 PF12796.7 EFC47069.1 - 0.13 12.9 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) DUF2140 PF09911.9 EFC47070.1 - 0.065 12.8 0.1 0.087 12.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) FR47 PF08445.10 EFC47070.1 - 0.067 13.2 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 FR47-like protein DUF3139 PF11337.8 EFC47070.1 - 0.34 11.6 3.8 4 8.2 3.4 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) LPAM_1 PF08139.12 EFC47070.1 - 0.54 10.8 3.3 1.6 9.4 3.3 1.9 1 1 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Pro-rich PF15240.6 EFC47070.1 - 1 9.6 3.1 1.6 9.0 3.1 1.5 1 1 0 1 1 1 0 Proline-rich Folate_carrier PF01770.18 EFC47070.1 - 6.6 5.4 4.9 15 4.2 4.9 1.6 1 1 0 1 1 1 0 Reduced folate carrier DUF4116 PF13475.6 EFC47071.1 - 1.9e-47 158.8 3.7 6.6e-21 73.8 0.0 3.1 1 1 3 4 4 4 4 Domain of unknown function (DUF4116) AF0941-like PF14591.6 EFC47071.1 - 0.0066 17.0 2.8 0.015 15.9 2.8 1.7 1 1 0 1 1 1 1 AF0941-like zf_C2H2_6 PF18450.1 EFC47071.1 - 0.087 12.6 2.4 10 5.9 0.0 3.2 3 1 1 4 4 4 0 Zinc Finger domain DUF4116 PF13475.6 EFC47072.1 - 7.1e-84 275.4 3.2 4.9e-19 67.8 0.0 6.4 4 2 3 7 7 7 7 Domain of unknown function (DUF4116) DUF1667 PF07892.11 EFC47072.1 - 2.3e-07 30.8 0.1 1.4 9.0 0.0 6.2 2 2 5 7 7 7 1 Protein of unknown function (DUF1667) zf_C2H2_6 PF18450.1 EFC47072.1 - 5.5e-05 22.8 0.1 7.6 6.3 0.0 5.2 5 0 0 5 5 5 1 Zinc Finger domain N6_N4_Mtase PF01555.18 EFC47072.1 - 0.00015 21.6 4.8 1 9.0 4.8 3.9 1 1 0 1 1 1 1 DNA methylase AfsA PF03756.13 EFC47072.1 - 0.031 14.3 0.1 22 5.0 0.0 3.4 1 1 3 4 4 4 0 A-factor biosynthesis hotdog domain AAA_18 PF13238.6 EFC47072.1 - 0.76 10.3 10.5 2.9 8.5 0.4 3.1 1 1 1 2 2 2 0 AAA domain AF0941-like PF14591.6 EFC47072.1 - 8.1 7.0 16.6 0.1 13.2 2.5 3.6 1 1 2 3 3 3 0 AF0941-like CN_hydrolase PF00795.22 EFC47073.1 - 2.5e-45 154.9 0.0 2.9e-45 154.6 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase SRR1 PF07985.12 EFC47075.1 - 2.4e-05 24.3 0.0 4.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 SRR1 baeRF_family6 PF18848.1 EFC47076.1 - 0.01 16.2 0.9 0.031 14.7 0.9 1.8 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 PhetRS_B1 PF18262.1 EFC47076.1 - 0.061 13.5 0.0 0.24 11.6 0.0 2.0 1 0 0 1 1 1 0 Phe-tRNA synthetase beta subunit B1 domain baeRF_family8 PF18851.1 EFC47076.1 - 0.066 13.3 2.0 0.07 13.2 0.2 2.0 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 8 Histone PF00125.24 EFC47077.1 - 4.5e-19 69.1 0.1 4.5e-19 69.1 0.1 1.8 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EFC47077.1 - 1e-15 57.2 1.3 1e-15 57.2 1.3 2.5 3 0 0 3 3 3 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EFC47077.1 - 0.00023 21.4 0.0 0.00047 20.4 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HbrB PF08539.11 EFC47077.1 - 1.2 9.1 3.1 2.8 7.9 0.1 2.5 2 1 1 3 3 3 0 HbrB-like Ribosomal_S3Ae PF01015.18 EFC47078.1 - 9.2e-30 103.7 7.4 9.2e-30 103.7 7.4 1.6 1 1 1 2 2 2 1 Ribosomal S3Ae family DUF1104 PF06518.11 EFC47078.1 - 0.02 15.3 2.6 0.15 12.5 2.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) Cytokin_check_N PF10407.9 EFC47078.1 - 0.068 13.1 0.1 0.18 11.8 0.1 1.7 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus Synaptobrevin PF00957.21 EFC47080.1 - 1.5 8.6 6.9 0.33 10.8 1.4 2.4 2 0 0 2 2 2 0 Synaptobrevin DUF4407 PF14362.6 EFC47080.1 - 3.3 7.0 8.1 8 5.7 8.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Amidohydro_1 PF01979.20 EFC47081.1 - 3e-71 240.5 0.0 3.6e-71 240.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 EFC47081.1 - 1.1e-08 35.0 0.0 3.6e-06 26.7 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 EFC47081.1 - 0.0043 16.4 0.0 0.0098 15.3 0.0 1.5 2 0 0 2 2 2 1 Adenosine/AMP deaminase VWA_2 PF13519.6 EFC47082.1 - 1e-06 29.3 0.0 1.5e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC47082.1 - 8e-05 22.9 0.0 0.00012 22.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC47082.1 - 0.0028 17.1 0.0 0.12 11.8 0.0 2.2 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein Tubulin PF00091.25 EFC47083.1 - 1.8e-36 126.2 0.1 4.1e-36 125.0 0.1 1.6 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 EFC47083.1 - 0.0016 17.7 0.8 0.0026 17.0 0.0 1.8 2 0 0 2 2 2 1 Tubulin like Misat_Tub_SegII PF10644.9 EFC47083.1 - 0.0016 18.7 0.3 0.021 15.1 0.0 2.4 2 1 0 2 2 2 1 Misato Segment II tubulin-like domain Lipase_3 PF01764.25 EFC47083.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) RabGAP-TBC PF00566.18 EFC47084.1 - 8.4e-48 162.9 3.0 8.4e-48 162.9 3.0 2.4 3 0 0 3 3 3 1 Rab-GTPase-TBC domain EB PF01683.18 EFC47085.1 - 1.8e-07 31.3 66.3 0.005 17.1 3.6 7.0 3 2 3 6 6 6 6 EB module VPDSG-CTERM PF18205.1 EFC47085.1 - 0.013 15.3 1.6 0.026 14.3 1.6 1.5 1 0 0 1 1 1 0 VPDSG-CTERM motif Kinesin PF00225.23 EFC47086.1 - 2.9e-95 319.0 0.2 5.7e-95 318.1 0.2 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC47086.1 - 4.6e-16 59.1 0.1 1.5e-15 57.4 0.1 1.9 1 0 0 1 1 1 1 Microtubule binding SAM_2 PF07647.17 EFC47086.1 - 1.3e-06 28.4 0.0 3.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 EFC47086.1 - 0.00023 21.6 0.3 0.00052 20.4 0.0 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Type2_restr_D3 PF16902.5 EFC47086.1 - 0.043 13.7 0.2 0.19 11.7 0.0 2.3 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain NCD1 PF04904.13 EFC47086.1 - 0.1 12.6 0.8 2.5 8.1 0.0 3.1 3 0 0 3 3 3 0 NAB conserved region 1 (NCD1) Sulf_transp PF04143.14 EFC47087.1 - 2.9e-64 217.6 15.8 3.7e-64 217.2 15.8 1.0 1 0 0 1 1 1 1 Sulphur transport COX14 PF14880.6 EFC47087.1 - 0.7 9.8 3.1 17 5.3 0.0 3.1 3 0 0 3 3 3 0 Cytochrome oxidase c assembly Polysacc_synt_C PF14667.6 EFC47087.1 - 2.2 8.3 13.5 0.34 11.0 3.6 3.1 2 1 1 3 3 3 0 Polysaccharide biosynthesis C-terminal domain DsbC PF11412.8 EFC47088.1 - 0.001 19.1 0.1 0.01 15.9 0.1 2.0 1 1 0 1 1 1 1 Disulphide bond corrector protein DsbC Abhydrolase_6 PF12697.7 EFC47089.1 - 3.3e-12 47.5 0.0 4.3e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC47089.1 - 3.1e-11 43.4 0.0 1.5e-08 34.6 0.0 2.1 1 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC47089.1 - 1.2e-05 24.7 0.0 2.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 EFC47089.1 - 0.00012 21.9 0.1 0.0016 18.2 0.1 2.3 2 1 0 2 2 2 1 PGAP1-like protein DUF900 PF05990.12 EFC47089.1 - 0.001 18.6 0.1 0.0016 18.0 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Abhydro_lipase PF04083.16 EFC47089.1 - 0.0028 17.2 0.0 0.0061 16.1 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Chlorophyllase2 PF12740.7 EFC47089.1 - 0.0051 15.7 0.2 0.024 13.5 0.2 1.9 1 1 0 1 1 1 1 Chlorophyllase enzyme DUF915 PF06028.11 EFC47089.1 - 0.023 14.0 0.2 0.063 12.6 0.2 1.8 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) LicD PF04991.13 EFC47089.1 - 0.079 13.1 2.5 0.16 12.1 2.5 1.6 1 1 0 1 1 1 0 LicD family Vac14_Fig4_bd PF11916.8 EFC47090.1 - 2.8e-68 229.1 11.1 2.8e-68 229.1 11.1 1.8 1 1 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 EFC47090.1 - 2.7e-36 124.0 1.4 7.8e-32 109.8 0.0 5.6 3 1 2 5 5 5 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 EFC47090.1 - 4.2e-12 46.4 5.8 0.00039 20.5 0.0 4.4 2 1 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFC47090.1 - 6.3e-06 26.0 0.1 0.081 13.2 0.0 5.5 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 EFC47090.1 - 6.2e-05 23.4 0.0 0.22 12.1 0.0 5.2 4 1 1 5 5 5 1 HEAT-like repeat RasGEF_N_2 PF14663.6 EFC47090.1 - 0.00071 19.9 5.0 0.19 12.2 0.4 4.0 3 1 0 4 4 4 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_2 PF13646.6 EFC47090.1 - 0.0014 19.0 0.0 12 6.4 0.0 4.1 3 1 0 4 4 4 2 HEAT repeats ABC_trans_N PF14510.6 EFC47090.1 - 0.0095 16.5 0.0 0.056 14.1 0.0 2.3 2 0 0 2 2 2 1 ABC-transporter N-terminal RTP1_C1 PF10363.9 EFC47090.1 - 0.019 15.1 0.2 0.65 10.2 0.1 3.2 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 F-box PF00646.33 EFC47091.1 - 0.0024 17.7 0.0 0.0074 16.1 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC47092.1 - 3.1e-07 30.2 0.0 6.4e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC47092.1 - 6.2e-05 22.8 0.0 0.00014 21.6 0.0 1.6 1 0 0 1 1 1 1 F-box domain G-alpha PF00503.20 EFC47092.1 - 0.00028 20.2 3.3 0.00028 20.2 3.3 2.4 1 1 1 2 2 2 1 G-protein alpha subunit Regnase_1_C PF18561.1 EFC47092.1 - 0.01 15.5 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain DUF2853 PF11015.8 EFC47092.1 - 0.032 14.9 0.2 0.61 10.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2853) RXT2_N PF08595.11 EFC47092.1 - 1.2 9.2 4.2 3.7 7.5 0.1 2.9 3 0 0 3 3 3 0 RXT2-like, N-terminal AMP-binding PF00501.28 EFC47093.1 - 2.6e-24 85.6 0.0 9.6e-16 57.4 0.0 2.2 2 1 0 2 2 2 2 AMP-binding enzyme gp12-short_mid PF09089.10 EFC47093.1 - 0.014 15.6 0.2 0.026 14.7 0.2 1.4 1 0 0 1 1 1 0 Phage short tail fibre protein gp12, middle domain Ank_2 PF12796.7 EFC47094.1 - 5.6e-21 74.9 4.6 2.7e-06 27.9 0.1 4.8 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC47094.1 - 9.7e-17 61.1 2.6 0.0027 18.3 0.2 5.9 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC47094.1 - 1e-16 60.8 0.5 0.0086 16.4 0.0 5.9 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC47094.1 - 2.6e-16 58.1 2.9 0.23 12.1 0.1 7.2 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 EFC47094.1 - 6.5e-05 23.2 0.9 1.9 9.1 0.0 5.7 7 0 0 7 7 7 1 Ankyrin repeat CCDC71L PF15374.6 EFC47094.1 - 0.022 14.0 1.5 0.037 13.3 1.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF1687 PF07955.11 EFC47094.1 - 0.042 14.3 1.9 0.05 14.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1687) RNase_PH_C PF03725.15 EFC47094.1 - 0.11 12.6 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 GDP_Man_Dehyd PF16363.5 EFC47095.1 - 1.9e-52 178.7 0.1 3.3e-52 177.9 0.1 1.3 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC47095.1 - 4e-45 154.2 0.1 5.1e-45 153.8 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC47095.1 - 1.3e-15 57.2 0.1 1.7e-15 56.8 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFC47095.1 - 1.3e-10 40.9 0.1 3.9e-10 39.3 0.1 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFC47095.1 - 1.2e-08 34.4 0.0 5.3e-07 29.1 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EFC47095.1 - 0.008 15.3 0.0 0.018 14.1 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 EFC47095.1 - 0.02 15.1 0.0 0.044 14.0 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFC47095.1 - 0.06 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 KR domain Ldh_1_N PF00056.23 EFC47095.1 - 0.066 13.3 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain DUF1815 PF08844.10 EFC47095.1 - 0.067 13.2 0.1 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1815) dCMP_cyt_deam_1 PF00383.23 EFC47096.1 - 0.00011 22.0 1.6 0.00021 21.1 1.6 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 EFC47096.1 - 0.00095 18.9 0.2 0.0023 17.7 0.2 1.6 1 0 0 1 1 1 1 MafB19-like deaminase Vps16_C PF04840.12 EFC47097.1 - 3.5e-47 161.0 17.3 6.3e-47 160.2 17.3 1.4 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 EFC47097.1 - 8.3e-40 136.8 0.0 8.4e-30 103.8 0.0 2.4 2 1 0 2 2 2 2 Vps16, N-terminal region IBD PF10416.9 EFC47097.1 - 0.02 14.9 0.2 0.02 14.9 0.2 3.4 4 0 0 4 4 4 0 Transcription-initiator DNA-binding domain IBD FAM176 PF14851.6 EFC47097.1 - 0.18 11.5 8.0 0.058 13.0 3.5 2.4 2 0 0 2 2 2 0 FAM176 family DUF3131 PF11329.8 EFC47098.1 - 0.33 10.0 1.7 8.2 5.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3131) Ank_2 PF12796.7 EFC47099.1 - 4.3e-37 126.6 16.5 3.2e-13 50.1 1.9 5.1 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC47099.1 - 5.3e-27 93.5 3.1 1.6e-06 28.2 0.1 7.9 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC47099.1 - 6.8e-27 93.5 7.1 1.4e-05 25.5 0.0 5.7 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EFC47099.1 - 9.2e-23 79.6 4.1 0.005 17.2 0.1 7.6 7 0 0 7 7 7 6 Ankyrin repeat Ank_3 PF13606.6 EFC47099.1 - 1.5e-22 77.3 9.6 0.023 15.2 0.0 8.0 8 0 0 8 8 8 6 Ankyrin repeat DcpS_C PF11969.8 EFC47101.1 - 3.3e-12 46.9 0.5 5.8e-12 46.1 0.1 1.6 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DUF2688 PF10892.8 EFC47101.1 - 0.031 13.8 0.1 0.077 12.5 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) DUF2616 PF11077.8 EFC47101.1 - 0.04 13.6 0.3 0.054 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) Ric8 PF10165.9 EFC47102.1 - 1.9e-11 43.7 17.8 1.3e-06 27.7 0.4 2.7 2 1 0 2 2 2 2 Guanine nucleotide exchange factor synembryn DUF4611 PF15387.6 EFC47102.1 - 0.39 11.0 8.7 19 5.6 6.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Flp1_like PF16982.5 EFC47102.1 - 0.96 8.9 4.1 13 5.3 0.2 3.0 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain Nup96 PF12110.8 EFC47103.1 - 1.5e-78 263.9 0.2 2.6e-78 263.1 0.2 1.4 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 EFC47103.1 - 4.1e-36 124.3 1.6 1.1e-35 123.0 1.6 1.8 1 0 0 1 1 1 1 Nucleoporin autopeptidase MRP-S28 PF10213.9 EFC47104.1 - 5.9e-05 23.5 0.9 0.0002 21.8 0.1 2.4 3 0 0 3 3 3 1 Mitochondrial ribosomal subunit protein Alba PF01918.21 EFC47105.1 - 1.8e-12 46.9 1.1 4e-12 45.8 0.8 1.6 1 1 1 2 2 2 1 Alba Rpp20 PF12328.8 EFC47105.1 - 0.0016 18.4 4.0 0.019 14.9 4.0 2.2 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Antimicrobial18 PF08130.11 EFC47105.1 - 0.0029 17.7 1.3 0.0031 17.6 0.1 1.8 2 0 0 2 2 2 1 Type A lantibiotic family Guanylate_cyc PF00211.20 EFC47106.1 - 0.03 13.9 0.2 0.074 12.7 0.2 1.7 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain MA3 PF02847.17 EFC47106.1 - 0.16 11.9 5.2 6.4 6.8 0.2 4.8 4 1 0 4 4 4 0 MA3 domain TPPII_N PF12583.8 EFC47106.1 - 0.21 12.2 0.6 0.51 10.9 0.6 1.5 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Ank_2 PF12796.7 EFC47107.1 - 3.7e-14 53.1 0.0 3.2e-06 27.6 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47107.1 - 3.1e-10 39.4 0.1 0.39 11.4 0.0 5.7 5 1 1 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 EFC47107.1 - 1.2e-09 38.5 0.0 5.2e-05 23.7 0.0 4.0 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC47107.1 - 2.4e-05 24.5 0.0 7.2 7.1 0.0 4.5 2 1 2 4 4 4 2 Ankyrin repeats (many copies) Pkinase PF00069.25 EFC47108.1 - 8.4e-40 136.8 0.5 8.4e-40 136.8 0.5 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47108.1 - 4.6e-22 78.5 0.1 8.7e-22 77.6 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TPR_19 PF14559.6 EFC47108.1 - 3e-05 24.4 0.0 0.2 12.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47108.1 - 0.0024 17.8 5.4 7 7.0 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC47108.1 - 0.0045 17.0 0.6 0.38 10.8 0.0 3.2 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 EFC47108.1 - 0.009 16.0 0.0 19 5.5 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC47108.1 - 0.021 14.5 1.2 0.2 11.4 0.2 2.9 3 0 0 3 3 3 0 26S proteasome subunit RPN7 MtrG PF04210.13 EFC47108.1 - 0.022 14.6 0.1 0.07 13.0 0.1 1.8 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G TPR_14 PF13428.6 EFC47108.1 - 0.027 15.3 0.0 3.3 8.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EFC47108.1 - 0.031 14.5 0.0 0.14 12.5 0.0 2.2 1 0 0 1 1 1 0 PPR repeat TPR_1 PF00515.28 EFC47108.1 - 0.048 13.5 5.1 4.8 7.2 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat SPOB_a PF14689.6 EFC47108.1 - 0.078 12.7 2.8 2.3 8.0 0.3 4.1 4 0 0 4 4 4 0 Sensor_kinase_SpoOB-type, alpha-helical domain TPR_6 PF13174.6 EFC47108.1 - 0.092 13.4 0.1 1.4e+02 3.5 0.1 4.4 6 0 0 6 6 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 EFC47108.1 - 0.11 12.7 0.1 0.33 11.2 0.1 1.8 1 0 0 1 1 1 0 PPR repeat family PI3K_rbd PF00794.18 EFC47108.1 - 0.12 12.5 0.8 0.41 10.8 0.3 2.2 2 0 0 2 2 2 0 PI3-kinase family, ras-binding domain Phosducin PF02114.16 EFC47110.1 - 2.5e-20 72.5 0.1 3.3e-20 72.1 0.1 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 EFC47110.1 - 2.3e-05 24.3 0.0 6e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin GLYCAM-1 PF05242.11 EFC47111.1 - 0.11 12.6 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) HHH_3 PF12836.7 EFC47111.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Sec23_helical PF04815.15 EFC47113.1 - 0.16 11.8 6.1 0.51 10.2 0.7 3.8 4 1 0 4 4 4 0 Sec23/Sec24 helical domain Tweety PF04906.13 EFC47113.1 - 7.2 5.2 15.4 0.04 12.6 3.0 3.0 3 2 1 4 4 4 0 Tweety MRP-L28 PF09812.9 EFC47114.1 - 0.024 14.8 2.4 0.028 14.5 2.4 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 Exo84_C PF16528.5 EFC47115.1 - 4.8e-06 26.5 1.7 4.8e-06 26.5 1.7 3.3 3 0 0 3 3 3 1 Exocyst component 84 C-terminal Vps51 PF08700.11 EFC47115.1 - 0.00047 20.2 2.0 0.0025 17.8 0.2 3.0 2 0 0 2 2 2 1 Vps51/Vps67 DUF5601 PF18151.1 EFC47115.1 - 0.097 13.0 5.0 2.7 8.4 0.6 4.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5601) HTH_40 PF14493.6 EFC47115.1 - 0.098 13.1 1.9 0.37 11.3 0.9 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain DUF1180 PF06679.12 EFC47115.1 - 3.9 7.9 9.5 12 6.3 9.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF3112 PF11309.8 EFC47115.1 - 4.6 6.6 7.1 0.15 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) YtxH PF12732.7 EFC47115.1 - 9.9 6.8 8.5 10 6.7 1.1 4.1 4 1 1 5 5 5 0 YtxH-like protein F_actin_bind PF08919.10 EFC47115.1 - 9.9 6.3 11.3 2 8.5 0.0 4.4 4 0 0 4 4 4 0 F-actin binding Trypsin_2 PF13365.6 EFC47116.1 - 2.3e-08 35.0 0.0 0.00064 20.7 0.0 2.7 3 0 0 3 3 3 2 Trypsin-like peptidase domain Pro_dh PF01619.18 EFC47118.1 - 4.6e-64 216.8 0.0 6.2e-64 216.4 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase Metallophos PF00149.28 EFC47119.1 - 1.4e-35 123.7 0.0 1.8e-35 123.3 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase 23S_rRNA_IVP PF05635.11 EFC47119.1 - 0.1 12.9 0.1 0.33 11.3 0.1 1.8 2 0 0 2 2 2 0 23S rRNA-intervening sequence protein STPPase_N PF16891.5 EFC47119.1 - 0.12 12.8 0.1 0.27 11.7 0.1 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Synaptobrevin PF00957.21 EFC47120.1 - 5.1e-27 93.5 6.1 8.4e-27 92.8 6.1 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 EFC47120.1 - 2.1e-21 75.7 0.0 3.4e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain RIFIN PF02009.16 EFC47120.1 - 0.00062 19.8 0.2 0.00095 19.1 0.2 1.3 1 0 0 1 1 1 1 Rifin MP PF01107.18 EFC47120.1 - 0.011 15.3 1.2 0.018 14.6 0.1 1.7 2 0 0 2 2 2 0 Viral movement protein (MP) Prominin PF05478.11 EFC47120.1 - 0.015 13.3 0.8 0.021 12.8 0.8 1.2 1 0 0 1 1 1 0 Prominin DUF2207 PF09972.9 EFC47120.1 - 0.059 12.1 0.3 0.081 11.7 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) E1-E2_ATPase PF00122.20 EFC47120.1 - 0.11 12.0 0.2 0.23 11.0 0.1 1.5 2 0 0 2 2 2 0 E1-E2 ATPase Orf78 PF06024.12 EFC47120.1 - 0.61 10.4 6.1 0.46 10.8 4.5 1.8 2 1 0 2 2 2 0 Orf78 (ac78) TMEM154 PF15102.6 EFC47120.1 - 1.5 8.7 4.6 1.8 8.5 3.5 1.6 1 1 0 1 1 1 0 TMEM154 protein family DUF3671 PF12420.8 EFC47120.1 - 1.8 8.6 12.7 3.3 7.8 6.2 2.4 2 1 0 2 2 2 0 Protein of unknown function ANAPC4_WD40 PF12894.7 EFC47121.1 - 0.006 16.8 0.0 51 4.2 0.0 3.9 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC47121.1 - 0.026 15.4 6.6 10 7.2 0.2 4.4 4 1 0 4 4 4 0 WD domain, G-beta repeat DUF4363 PF14276.6 EFC47121.1 - 0.86 9.7 8.4 0.95 9.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) Proteasom_PSMB PF10508.9 EFC47123.1 - 4.6e-35 121.1 6.1 1.1e-34 119.8 6.1 1.5 1 1 0 1 1 1 1 Proteasome non-ATPase 26S subunit PPR_2 PF13041.6 EFC47123.1 - 0.089 13.0 0.1 14 6.0 0.0 3.2 3 0 0 3 3 3 0 PPR repeat family FH2 PF02181.23 EFC47125.1 - 1.8e-51 175.4 7.8 2.9e-51 174.7 7.8 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain PTEN_C2 PF10409.9 EFC47125.1 - 4.4e-08 33.0 0.9 1.3e-07 31.5 0.1 2.3 2 0 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein LRR_RI_capping PF18779.1 EFC47125.1 - 0.092 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Capping Ribonuclease inhibitor Leucine Rich Repeat DUF3496 PF12001.8 EFC47125.1 - 0.31 11.5 4.8 15 6.0 0.3 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3496) Uricase PF01014.18 EFC47125.1 - 1.2 9.4 0.0 1.2 9.4 0.0 3.1 4 0 0 4 4 4 0 Uricase LRR_6 PF13516.6 EFC47126.1 - 2.8e-43 142.3 38.2 5.1e-05 23.0 0.3 12.0 12 0 0 12 12 12 10 Leucine Rich repeat LRR_4 PF12799.7 EFC47126.1 - 2.2e-06 27.9 24.0 0.26 11.8 0.1 8.0 6 3 0 7 7 7 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47126.1 - 0.0011 18.7 25.6 2.6 7.9 2.0 8.6 3 2 4 7 7 7 4 Leucine rich repeat LRR_1 PF00560.33 EFC47126.1 - 0.0011 19.2 7.2 79 4.4 0.1 7.9 9 0 0 9 9 9 0 Leucine Rich Repeat Pyr_redox_2 PF07992.14 EFC47129.1 - 1.1e-24 87.3 0.1 8.5e-24 84.3 0.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC47129.1 - 4e-07 29.1 0.1 0.001 17.8 0.0 2.6 3 0 0 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 EFC47129.1 - 5.3e-07 29.1 0.0 0.00024 20.3 0.0 2.9 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.6 EFC47129.1 - 6e-07 29.0 0.9 0.0008 18.8 0.2 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC47129.1 - 0.00034 20.3 0.0 0.0049 16.5 0.0 2.4 1 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 EFC47129.1 - 0.00036 19.8 6.7 0.026 13.6 0.1 3.5 3 1 1 4 4 4 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 EFC47129.1 - 0.00042 20.5 0.0 0.00087 19.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 EFC47129.1 - 0.0023 17.3 0.0 0.0038 16.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC47129.1 - 0.013 14.7 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 EFC47129.1 - 0.025 13.9 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 EFC47129.1 - 0.033 13.4 0.2 0.092 12.0 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 EFC47129.1 - 0.041 14.4 0.1 0.65 10.6 0.0 2.8 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC47129.1 - 0.2 10.7 0.2 1.2 8.1 0.1 2.1 2 1 1 3 3 3 0 Lycopene cyclase protein Pkinase PF00069.25 EFC47130.1 - 1.3e-75 254.2 3.9 2.7e-75 253.1 0.1 2.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47130.1 - 3.9e-33 114.8 5.9 7.2e-33 113.9 0.0 3.5 3 1 0 3 3 3 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC47130.1 - 3.3e-09 36.5 1.0 0.00078 18.8 0.1 3.6 2 1 0 2 2 2 2 Kinase-like Acetyltransf_CG PF14542.6 EFC47132.1 - 4.9e-25 87.5 0.4 7.3e-25 86.9 0.4 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_15 PF17013.5 EFC47132.1 - 0.00023 20.7 0.2 0.00025 20.6 0.2 1.1 1 0 0 1 1 1 1 Putative acetyl-transferase Pkinase PF00069.25 EFC47133.1 - 1.1e-59 202.0 0.2 1.2e-59 201.8 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47133.1 - 3.2e-43 147.9 0.1 4e-43 147.6 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC47133.1 - 8.1e-05 21.6 0.0 0.00013 20.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 EFC47133.1 - 0.0011 18.4 0.0 0.013 14.9 0.0 2.0 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 EFC47133.1 - 0.14 12.0 0.1 0.28 11.1 0.0 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family PIP5K PF01504.18 EFC47134.1 - 1.1e-71 241.3 6.5 4.6e-71 239.2 6.5 2.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase TPR_1 PF00515.28 EFC47134.1 - 1.1e-20 72.6 20.6 0.00012 21.7 0.0 9.0 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47134.1 - 4.8e-18 63.8 17.7 0.0017 18.4 0.5 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47134.1 - 2.1e-13 49.3 14.6 0.033 14.3 0.1 8.7 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC47134.1 - 5.2e-12 45.3 25.1 0.0089 16.3 0.1 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47134.1 - 1.4e-08 35.1 0.7 0.059 13.9 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47134.1 - 5.1e-08 32.5 3.0 0.04 13.6 0.6 4.6 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 EFC47134.1 - 1.6e-07 31.5 0.8 0.36 11.2 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47134.1 - 9.9e-07 29.3 0.0 0.16 12.6 0.0 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC47134.1 - 1.9e-06 28.2 0.0 0.32 11.9 0.0 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47134.1 - 4.8e-06 26.2 0.0 0.42 10.8 0.0 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat Ank_3 PF13606.6 EFC47134.1 - 5.5e-06 26.3 0.0 0.011 16.2 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 EFC47134.1 - 6.6e-06 26.6 0.0 3e-05 24.5 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC47134.1 - 9.9e-06 25.7 0.0 0.019 15.3 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TPR_10 PF13374.6 EFC47134.1 - 9.4e-05 22.2 0.1 0.96 9.4 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Ank_4 PF13637.6 EFC47134.1 - 0.00079 19.9 0.0 0.059 14.0 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TPR_6 PF13174.6 EFC47134.1 - 0.0034 17.9 0.5 3.1 8.6 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Ank PF00023.30 EFC47134.1 - 0.0067 16.8 0.0 0.12 12.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat SPOB_a PF14689.6 EFC47134.1 - 0.022 14.5 0.2 0.13 12.0 0.0 2.5 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain ANAPC5 PF12862.7 EFC47134.1 - 0.32 11.1 2.3 0.5 10.5 0.1 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Rhodanese PF00581.20 EFC47135.1 - 3.8e-07 30.6 0.1 3.6e-05 24.2 0.1 2.2 1 1 0 1 1 1 1 Rhodanese-like domain ADP_ribosyl_GH PF03747.14 EFC47136.1 - 3.8e-53 181.1 0.0 7.6e-53 180.1 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase LRR_6 PF13516.6 EFC47137.1 - 4.4e-40 132.3 16.6 0.00015 21.5 0.1 10.1 10 0 0 10 10 10 8 Leucine Rich repeat LRR_4 PF12799.7 EFC47137.1 - 9.8e-18 64.0 37.8 0.00042 20.6 1.8 6.8 2 2 7 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47137.1 - 4.6e-17 61.5 28.5 1.4e-05 24.8 4.3 4.9 2 2 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFC47137.1 - 1.2e-09 37.4 18.8 11 7.1 0.5 9.7 8 2 0 8 8 8 2 Leucine Rich Repeat F-box-like PF12937.7 EFC47137.1 - 0.00015 21.6 0.0 0.00039 20.2 0.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_9 PF14580.6 EFC47137.1 - 0.00054 19.5 9.5 0.072 12.6 1.2 3.3 1 1 1 3 3 3 2 Leucine-rich repeat F-box PF00646.33 EFC47137.1 - 0.0065 16.3 0.1 0.025 14.4 0.0 2.0 2 0 0 2 2 2 1 F-box domain DUF4116 PF13475.6 EFC47138.1 - 3.1e-158 513.5 64.9 2.1e-15 56.2 0.0 19.0 12 4 6 20 20 20 19 Domain of unknown function (DUF4116) DUF4362 PF14275.6 EFC47138.1 - 0.013 15.7 1.2 0.048 13.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4362) ThylakoidFormat PF11264.8 EFC47138.1 - 0.036 13.8 0.5 0.12 12.1 0.5 1.8 1 0 0 1 1 1 0 Thylakoid formation protein cobW PF02492.19 EFC47139.1 - 4e-59 199.2 0.8 5.5e-59 198.7 0.8 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 EFC47139.1 - 3.6e-19 68.5 0.0 1e-18 67.1 0.0 1.7 2 0 0 2 2 2 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 EFC47139.1 - 1.2e-05 25.3 0.5 0.0077 16.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC47139.1 - 0.00098 19.2 0.2 0.0045 17.0 0.2 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC47139.1 - 0.0016 18.7 0.9 0.021 15.1 0.5 2.8 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 EFC47139.1 - 0.022 15.0 2.2 2.4 8.4 0.0 2.7 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 EFC47139.1 - 0.024 13.6 0.1 0.2 10.6 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 EFC47139.1 - 0.031 14.3 1.3 1.9 8.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family ABC_tran PF00005.27 EFC47139.1 - 0.034 14.6 0.6 0.078 13.5 0.6 1.8 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EFC47139.1 - 0.035 13.8 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1840 PF08895.11 EFC47139.1 - 0.048 14.0 4.8 0.098 13.0 1.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Mak16 PF04874.14 EFC47139.1 - 0.12 12.9 11.2 0.73 10.5 5.6 2.3 2 0 0 2 2 2 0 Mak16 protein C-terminal region AAA_16 PF13191.6 EFC47139.1 - 0.14 12.6 0.0 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 EFC47139.1 - 0.15 11.8 0.4 0.28 10.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC47139.1 - 0.3 11.7 3.8 0.74 10.4 0.0 2.8 2 1 1 3 3 3 0 AAA domain FAM176 PF14851.6 EFC47139.1 - 6.2 6.5 7.7 1.6 8.4 1.8 2.2 2 0 0 2 2 2 0 FAM176 family DUF4628 PF15429.6 EFC47139.1 - 7.8 6.1 8.5 0.83 9.3 3.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4628) DUF3517 PF12030.8 EFC47140.1 - 0.015 14.2 0.1 0.016 14.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3517) Peptidase_M3_N PF08439.10 EFC47140.1 - 1.4 9.2 4.0 25 5.2 0.1 2.4 1 1 1 2 2 2 0 Oligopeptidase F Sar8_2 PF03058.14 EFC47140.1 - 4.6 7.9 10.8 0.69 10.5 2.6 2.2 1 1 2 3 3 3 0 Sar8.2 family Endonuclease_5 PF04493.14 EFC47141.1 - 9e-60 201.7 0.0 1.1e-59 201.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V UvrC_HhH_N PF08459.11 EFC47141.1 - 0.027 14.4 0.0 0.057 13.3 0.0 1.6 1 1 0 1 1 1 0 UvrC Helix-hairpin-helix N-terminal RGS PF00615.19 EFC47143.1 - 5.1e-07 30.0 8.8 1.3e-05 25.4 8.8 2.7 1 1 0 1 1 1 1 Regulator of G protein signaling domain COX2_TM PF02790.15 EFC47143.1 - 0.2 11.8 3.5 0.89 9.7 0.2 2.6 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain PsbI PF02532.14 EFC47143.1 - 0.37 10.8 5.2 0.81 9.7 5.2 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) CPSF100_C PF13299.6 EFC47143.1 - 1.9 8.7 6.7 12 6.0 0.1 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4400 PF14348.6 EFC47143.1 - 4.3 6.8 7.4 0.28 10.7 0.7 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4400) Actin PF00022.19 EFC47145.1 - 7.7e-113 377.2 0.0 8.3e-111 370.5 0.0 2.0 1 1 0 1 1 1 1 Actin LRR_6 PF13516.6 EFC47146.1 - 4e-54 176.1 13.6 0.00012 21.9 0.0 11.8 12 0 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC47146.1 - 3.4e-43 145.2 40.6 1.8e-08 34.0 0.5 5.2 1 1 7 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC47146.1 - 5.4e-30 102.9 16.5 0.00011 22.5 3.1 7.5 1 1 8 10 10 10 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47146.1 - 5.1e-18 62.8 0.1 3 8.7 0.1 9.9 11 0 0 11 11 11 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC47146.1 - 3.6e-09 36.4 2.8 0.0066 16.0 0.1 3.2 1 1 1 3 3 3 3 Leucine-rich repeat Beta_helix PF13229.6 EFC47146.1 - 0.00012 22.0 4.0 0.085 12.7 0.4 2.3 1 1 1 2 2 2 2 Right handed beta helix region DUF2922 PF11148.8 EFC47146.1 - 0.039 13.7 1.0 0.23 11.2 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2922) DUF1825 PF08855.10 EFC47146.1 - 0.17 11.8 2.2 2.8 7.9 0.0 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF1825) ApoB100_C PF12491.8 EFC47146.1 - 4.1 7.4 18.7 9.2 6.3 0.2 7.3 4 4 4 9 9 9 0 Apolipoprotein B100 C terminal LRR_6 PF13516.6 EFC47147.1 - 1.3e-43 143.3 38.2 4.5e-05 23.2 0.0 13.0 13 0 0 13 13 13 10 Leucine Rich repeat LRR_8 PF13855.6 EFC47147.1 - 4.2e-29 100.1 28.1 2.6e-08 33.5 0.6 6.2 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 EFC47147.1 - 8.1e-24 83.3 33.6 4.7e-05 23.7 0.4 8.1 3 3 5 9 9 9 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47147.1 - 7.8e-13 47.1 21.6 0.25 12.0 0.0 11.9 13 0 0 13 13 13 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC47147.1 - 6e-08 32.4 6.8 5e-05 22.9 0.4 3.2 1 1 2 3 3 3 3 Leucine-rich repeat HTH_9 PF08221.11 EFC47147.1 - 0.15 12.2 3.1 19 5.4 0.2 4.5 4 2 1 5 5 5 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Beta_helix PF13229.6 EFC47147.1 - 0.49 10.2 22.7 0.71 9.7 4.9 2.9 1 1 1 2 2 2 0 Right handed beta helix region RCC1 PF00415.18 EFC47148.1 - 2.9e-49 165.5 12.3 2e-06 28.3 0.3 13.5 13 1 0 13 13 13 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC47148.1 - 1.4e-41 139.5 22.7 4.4e-08 32.7 0.1 11.8 11 0 0 11 11 11 8 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC47148.1 - 5.4e-40 137.4 0.5 1.1e-39 136.4 0.5 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47148.1 - 1.3e-27 96.8 0.1 3.2e-20 72.5 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase EGF_2 PF07974.13 EFC47148.1 - 0.0015 18.9 8.5 0.0015 18.9 8.5 2.8 2 0 0 2 2 2 1 EGF-like domain Haspin_kinase PF12330.8 EFC47148.1 - 0.0059 15.6 0.5 0.01 14.8 0.5 1.3 1 0 0 1 1 1 1 Haspin like kinase domain EGF PF00008.27 EFC47148.1 - 0.059 13.7 7.5 0.12 12.7 3.8 2.7 2 0 0 2 2 2 0 EGF-like domain EGF_alliinase PF04863.13 EFC47148.1 - 2.9 8.4 11.3 8.4 6.9 11.3 1.8 1 0 0 1 1 1 0 Alliinase EGF-like domain hEGF PF12661.7 EFC47148.1 - 3.3 8.5 8.6 1.9 9.2 3.5 2.9 2 0 0 2 2 2 0 Human growth factor-like EGF Acetyltransf_3 PF13302.7 EFC47149.1 - 2.8e-15 57.2 0.0 3.2e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC47149.1 - 8.6e-05 22.8 0.0 0.0003 21.0 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC47149.1 - 0.0036 17.2 0.0 0.0087 16.0 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC47149.1 - 0.0052 16.9 0.1 0.0066 16.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 EFC47149.1 - 0.044 13.5 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC47149.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.5 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain AAA-ATPase_like PF09820.9 EFC47150.1 - 2e-56 191.5 6.1 2e-56 191.5 6.1 1.4 2 0 0 2 2 2 1 Predicted AAA-ATPase REJ PF02010.15 EFC47151.1 - 7.1e-45 153.6 9.4 7.1e-45 153.6 9.4 3.0 2 1 1 3 3 3 2 REJ domain Oxidored_molyb PF00174.19 EFC47151.1 - 4.3e-16 59.0 0.0 8.6e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain EGF_2 PF07974.13 EFC47151.1 - 1.8e-06 28.2 186.0 0.0016 18.8 7.9 12.9 11 2 2 13 13 13 7 EGF-like domain LRR_4 PF12799.7 EFC47151.1 - 4.8e-05 23.6 25.4 0.00067 20.0 6.8 5.1 3 1 3 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47151.1 - 0.00095 18.9 27.5 0.049 13.4 0.2 3.8 3 1 0 4 4 4 2 Leucine rich repeat DUF919 PF06034.11 EFC47151.1 - 0.013 15.3 1.4 0.029 14.2 1.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) LRR_9 PF14580.6 EFC47151.1 - 0.11 12.0 13.7 0.79 9.2 5.1 3.2 2 1 1 3 3 3 0 Leucine-rich repeat SpaA PF17802.1 EFC47151.1 - 0.35 11.2 16.7 0.084 13.2 3.3 4.8 5 0 0 5 5 5 0 Prealbumin-like fold domain Ras PF00071.22 EFC47152.1 - 2.1e-12 46.9 2.1 7.1e-12 45.2 2.1 1.8 1 1 0 1 1 1 1 Ras family Arf PF00025.21 EFC47152.1 - 0.0002 20.9 0.0 0.054 12.9 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC47152.1 - 0.0046 16.5 0.1 0.0097 15.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EFC47152.1 - 0.039 14.0 0.2 0.16 12.0 0.1 2.1 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Roc PF08477.13 EFC47152.1 - 0.043 14.0 0.1 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase CbiA PF01656.23 EFC47152.1 - 0.068 13.2 0.0 0.14 12.2 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain LRR_6 PF13516.6 EFC47153.1 - 4.7e-33 110.4 8.2 0.00023 21.0 0.0 8.9 9 0 0 9 9 9 8 Leucine Rich repeat LRR_8 PF13855.6 EFC47153.1 - 6.7e-26 89.8 9.2 4.5e-07 29.5 0.0 4.9 1 1 6 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC47153.1 - 7e-20 70.8 6.9 0.0024 18.2 0.0 7.4 2 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47153.1 - 1.6e-11 43.1 0.1 5.3 8.0 0.0 8.0 7 1 1 8 8 8 2 Leucine Rich Repeat Ras PF00071.22 EFC47155.1 - 2.8e-06 27.0 0.0 0.00043 19.9 0.0 2.2 2 0 0 2 2 2 2 Ras family LRR_6 PF13516.6 EFC47156.1 - 4.2e-32 107.4 58.1 0.00018 21.3 0.0 15.3 16 0 0 16 16 16 10 Leucine Rich repeat LRR_4 PF12799.7 EFC47156.1 - 9e-14 51.4 89.2 0.0086 16.5 5.7 12.9 6 4 8 16 16 16 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47156.1 - 6.5e-07 29.0 58.7 3.9 8.4 0.4 14.5 14 0 0 14 14 14 6 Leucine Rich Repeat LRR_2 PF07723.13 EFC47156.1 - 0.00016 22.2 3.2 16 6.4 0.0 6.1 5 0 0 5 5 5 1 Leucine Rich Repeat F-box PF00646.33 EFC47156.1 - 0.0029 17.4 0.1 0.0085 15.9 0.1 1.8 1 0 0 1 1 1 1 F-box domain YdiH PF15930.5 EFC47156.1 - 0.0047 17.1 0.4 1.4 9.1 0.0 3.6 4 0 0 4 4 4 1 Domain of unknown function F-box-like PF12937.7 EFC47156.1 - 0.017 15.0 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 F-box-like DUF3198 PF11433.8 EFC47156.1 - 0.061 13.2 2.1 0.25 11.2 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3198) DUF3719 PF12516.8 EFC47156.1 - 0.087 12.5 0.0 20 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3719) LRR_9 PF14580.6 EFC47156.1 - 0.2 11.2 17.5 0.34 10.4 2.8 3.9 2 2 1 3 3 3 0 Leucine-rich repeat LRR_6 PF13516.6 EFC47157.1 - 1.7e-16 58.8 2.4 0.00016 21.4 0.0 5.0 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 EFC47157.1 - 2.7e-10 40.3 5.4 0.0012 19.2 0.0 3.6 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47157.1 - 5e-06 26.2 4.5 0.013 15.2 0.2 3.2 1 1 3 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFC47157.1 - 3e-05 24.0 2.4 1.1 10.0 0.0 4.2 3 2 0 3 3 3 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC47157.1 - 0.045 13.3 0.1 0.12 11.9 0.1 1.5 1 1 0 1 1 1 0 Leucine-rich repeat BAP PF06639.11 EFC47158.1 - 1.4 9.3 4.9 2.5 8.5 0.8 2.6 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) COX2 PF00116.20 EFC47159.1 - 0.2 11.6 2.1 5.2 7.0 0.3 2.5 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, periplasmic domain CoA_transf_3 PF02515.17 EFC47160.1 - 6.2e-39 134.2 0.0 1.2e-36 126.7 0.0 2.2 2 0 0 2 2 2 2 CoA-transferase family III AbiH PF14253.6 EFC47160.1 - 0.012 15.5 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH HAGH_C PF16123.5 EFC47162.1 - 1.3e-14 54.4 1.3 2.2e-14 53.7 0.4 1.8 2 0 0 2 2 2 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 EFC47162.1 - 1.2e-11 45.0 0.0 2.3e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC47162.1 - 0.054 13.0 0.0 0.098 12.2 0.0 1.7 1 1 0 1 1 1 0 Beta-lactamase superfamily domain F-box-like PF12937.7 EFC47163.1 - 0.098 12.6 1.0 0.31 11.0 1.0 1.9 1 0 0 1 1 1 0 F-box-like Ank_2 PF12796.7 EFC47164.1 - 7.2e-28 97.0 0.3 3.3e-13 50.0 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47164.1 - 4.9e-27 91.0 0.5 2.1e-06 27.6 0.0 5.2 4 1 1 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 EFC47164.1 - 4.2e-21 75.0 0.0 6.3e-06 26.6 0.0 4.4 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC47164.1 - 1.4e-19 69.9 0.0 3.1e-05 24.2 0.0 5.0 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC47164.1 - 9.7e-19 66.9 0.2 0.011 16.2 0.0 5.1 4 1 1 5 5 5 5 Ankyrin repeat DUF249 PF03158.13 EFC47164.1 - 0.0004 20.2 0.2 0.11 12.3 0.1 2.5 1 1 0 2 2 2 2 Multigene family 530 protein Rota_NSP3 PF01665.16 EFC47164.1 - 0.015 14.5 0.6 0.025 13.7 0.6 1.3 1 1 0 1 1 1 0 Rotavirus non-structural protein NSP3 OpuAC PF04069.12 EFC47164.1 - 0.057 13.0 0.0 0.14 11.8 0.0 1.6 1 1 1 2 2 2 0 Substrate binding domain of ABC-type glycine betaine transport system RIH_assoc PF08454.11 EFC47164.1 - 0.46 10.4 3.9 1 9.3 2.5 2.2 2 1 0 2 2 2 0 RyR and IP3R Homology associated FAD_binding_4 PF01565.23 EFC47165.1 - 9.2e-13 48.1 2.4 2e-11 43.8 2.4 2.3 1 1 0 1 1 1 1 FAD binding domain Cytokin-bind PF09265.10 EFC47165.1 - 2.1e-09 37.2 0.0 6.4e-09 35.6 0.0 1.8 1 1 0 1 1 1 1 Cytokinin dehydrogenase 1, FAD and cytokinin binding BBE PF08031.12 EFC47165.1 - 0.026 14.6 1.8 0.067 13.3 1.8 1.7 1 0 0 1 1 1 0 Berberine and berberine like EGF_2 PF07974.13 EFC47166.1 - 1.9e-35 120.9 170.2 1.4e-06 28.6 3.0 12.9 12 1 0 12 12 12 12 EGF-like domain Guanylate_cyc PF00211.20 EFC47166.1 - 2.1e-05 24.2 0.6 4e-05 23.3 0.1 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain EGF_2 PF07974.13 EFC47167.1 - 4e-19 68.7 94.9 0.00024 21.4 4.4 7.1 7 0 0 7 7 7 6 EGF-like domain REJ PF02010.15 EFC47167.1 - 1.7e-18 66.7 15.2 1.7e-18 66.7 15.2 3.9 2 2 1 3 3 3 2 REJ domain EGF PF00008.27 EFC47167.1 - 0.00022 21.4 60.4 0.0083 16.4 5.9 7.1 6 0 0 6 6 6 4 EGF-like domain NHL PF01436.21 EFC47167.1 - 0.47 10.6 1.9 78 3.6 0.0 4.8 5 0 0 5 5 5 0 NHL repeat LRR_4 PF12799.7 EFC47168.1 - 3.9e-32 109.7 52.0 4.9e-07 30.0 2.3 7.4 2 1 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47168.1 - 5.8e-20 70.8 44.7 1.3e-06 28.1 3.4 6.4 2 2 5 8 8 8 8 Leucine rich repeat LRR_9 PF14580.6 EFC47168.1 - 2.3e-17 63.1 26.7 2.1e-09 37.1 5.1 4.1 1 1 4 5 5 5 5 Leucine-rich repeat UBA2_C PF16195.5 EFC47168.1 - 0.022 15.4 3.7 0.033 14.8 3.7 1.2 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus LRR_6 PF13516.6 EFC47168.1 - 0.47 10.6 22.0 1.4 9.1 0.3 7.8 9 0 0 9 9 9 0 Leucine Rich repeat LRR_1 PF00560.33 EFC47168.1 - 0.98 10.2 34.5 6.3 7.8 0.7 9.5 9 3 0 9 9 9 0 Leucine Rich Repeat FpoO PF10621.9 EFC47169.1 - 0.00086 19.6 6.3 7 7.0 0.1 5.8 6 0 0 6 6 6 1 F420H2 dehydrogenase subunit FpoO HlyD_2 PF12700.7 EFC47169.1 - 0.12 11.1 0.3 1.2 7.8 0.0 2.6 2 1 1 3 3 3 0 HlyD family secretion protein PCMT PF01135.19 EFC47169.1 - 0.12 12.1 0.0 19 4.9 0.0 2.9 3 0 0 3 3 3 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DIL PF01843.19 EFC47169.1 - 7.5 6.9 17.7 8.5 6.7 0.1 6.5 7 2 1 8 8 8 0 DIL domain NUDIX PF00293.28 EFC47170.1 - 1.3e-09 38.2 0.0 1.8e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DBC1 PF14443.6 EFC47170.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 DBC1 NUDIX_4 PF14815.6 EFC47170.1 - 0.19 11.7 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain ERG4_ERG24 PF01222.17 EFC47171.1 - 2.1e-86 290.3 19.3 2.5e-86 290.1 19.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 EFC47171.1 - 3.6e-05 23.4 0.7 0.0001 21.9 0.7 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) DJ-1_PfpI PF01965.24 EFC47172.1 - 0.0017 18.2 0.0 0.0061 16.4 0.0 2.0 1 1 0 1 1 1 1 DJ-1/PfpI family Catalase_C PF18011.1 EFC47172.1 - 0.01 15.5 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 C-terminal domain found in long catalases RNA_ligase PF09414.10 EFC47173.1 - 3.1e-26 92.6 0.2 4.8e-26 92.0 0.2 1.3 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 EFC47173.1 - 1.2e-10 41.4 3.0 1.2e-10 41.4 3.0 2.2 1 1 1 2 2 2 1 T4 RNA ligase 2 C-terminal Kinesin PF00225.23 EFC47174.1 - 2.7e-78 263.3 7.3 3.2e-42 144.6 1.1 2.7 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 EFC47174.1 - 1.5e-26 93.1 1.9 2.2e-26 92.6 0.2 2.2 2 0 0 2 2 2 1 Microtubule binding RILP PF11461.8 EFC47174.1 - 0.018 15.2 2.1 0.018 15.2 2.1 3.1 3 0 0 3 3 3 0 Rab interacting lysosomal protein DUF2385 PF09539.10 EFC47174.1 - 0.094 13.3 0.0 0.72 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2385) Secretin PF00263.21 EFC47175.1 - 0.034 13.8 0.2 0.043 13.5 0.2 1.3 1 1 0 1 1 1 0 Bacterial type II and III secretion system protein Ras PF00071.22 EFC47176.1 - 6.1e-33 113.7 0.0 1.2e-27 96.5 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC47176.1 - 1.1e-16 61.1 0.0 3.4e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47176.1 - 4.7e-06 26.2 0.0 7.6e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC47176.1 - 0.0077 15.7 0.0 0.022 14.2 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Nucleoplasmin PF03066.15 EFC47176.1 - 0.16 12.5 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 Nucleoplasmin/nucleophosmin domain Ank_4 PF13637.6 EFC47177.1 - 2e-20 72.9 0.2 1.1e-06 29.0 0.0 2.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC47177.1 - 1.8e-17 63.7 0.1 3e-17 63.0 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC47177.1 - 1.8e-17 63.2 0.0 1.7e-11 44.2 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC47177.1 - 4.2e-15 54.3 0.0 8.8e-06 25.7 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFC47177.1 - 2.7e-13 49.7 0.0 6.4e-07 29.5 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeat PRK PF00485.18 EFC47178.1 - 4.5e-19 69.0 0.0 2.4e-18 66.6 0.0 2.0 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 EFC47178.1 - 0.0033 17.6 0.0 0.0069 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC47178.1 - 0.024 15.2 0.0 0.06 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFC47178.1 - 0.051 13.5 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 EFC47178.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFC47178.1 - 0.17 10.9 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein UDG PF03167.19 EFC47179.1 - 1.6e-08 34.7 0.0 2.9e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily NAF PF03822.14 EFC47179.1 - 0.1 12.8 1.2 0.33 11.2 0.1 2.3 2 0 0 2 2 2 0 NAF domain FWWh PF14922.6 EFC47180.1 - 1.6e-09 37.8 12.9 6.3e-09 35.9 10.5 2.7 2 1 0 2 2 2 1 Protein of unknown function Ubiq_cyt_C_chap PF03981.12 EFC47181.1 - 5.9e-12 45.9 0.0 1.1e-10 41.7 0.0 2.3 2 0 0 2 2 2 1 Ubiquinol-cytochrome C chaperone Imm5 PF14423.6 EFC47181.1 - 0.0077 16.5 0.6 0.039 14.2 0.0 2.3 2 1 1 3 3 3 1 Immunity protein Imm5 FYRC PF05965.14 EFC47181.1 - 0.1 12.8 0.0 0.31 11.2 0.0 1.7 1 0 0 1 1 1 0 F/Y rich C-terminus DUF4115 PF13464.6 EFC47182.1 - 0.083 13.1 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) HHA PF05321.11 EFC47182.1 - 6.1 7.2 5.8 3.2 8.2 0.3 2.8 2 1 1 3 3 3 0 Haemolysin expression modulating protein Acyltransferase PF01553.21 EFC47183.1 - 6.9e-20 71.0 0.0 1e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Spidroin_N PF16763.5 EFC47183.1 - 0.032 14.2 1.2 0.054 13.5 0.3 1.7 2 0 0 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term DAGAT PF03982.13 EFC47183.1 - 0.18 10.7 0.0 3.7 6.4 0.0 2.2 1 1 1 2 2 2 0 Diacylglycerol acyltransferase Arm PF00514.23 EFC47185.1 - 0.013 15.6 0.2 1.5 8.9 0.0 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC47185.1 - 0.064 13.8 0.0 4.8 7.8 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat Mrpl_C PF18502.1 EFC47185.1 - 0.41 10.9 3.4 0.33 11.2 1.1 2.1 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain Kinesin PF00225.23 EFC47186.1 - 2.4e-111 371.9 5.6 2.4e-111 371.9 5.6 3.0 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC47186.1 - 5.6e-30 104.2 0.6 5.6e-30 104.2 0.6 3.6 3 1 0 4 4 4 1 Microtubule binding Microtub_bind PF13931.6 EFC47186.1 - 2.8e-09 37.5 2.0 2.8e-09 37.5 2.0 6.4 4 2 1 5 5 5 1 Kinesin-associated microtubule-binding FXMR_C2 PF16098.5 EFC47186.1 - 0.024 15.1 0.3 0.088 13.3 0.3 2.1 1 0 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 DUF4413 PF14372.6 EFC47186.1 - 0.18 12.2 0.1 0.18 12.2 0.1 4.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4413) DUF2773 PF10971.8 EFC47186.1 - 0.4 10.8 2.2 3.6 7.8 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2773) DUF2383 PF09537.10 EFC47186.1 - 0.51 10.7 10.2 0.5 10.7 3.0 4.4 3 1 0 3 3 3 0 Domain of unknown function (DUF2383) LtuB PF17455.2 EFC47186.1 - 0.52 11.0 8.2 4.5 8.0 0.7 3.6 4 0 0 4 4 4 0 Late transcription unit B ABC1 PF03109.16 EFC47186.1 - 0.64 10.2 5.0 0.49 10.6 0.3 3.1 2 1 0 2 2 2 0 ABC1 family TBP PF00352.21 EFC47187.1 - 1.3e-66 220.5 0.3 2.8e-32 110.5 0.3 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 EFC47187.1 - 2.1e-06 27.8 0.0 0.019 15.0 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) Methyltransf_31 PF13847.6 EFC47188.1 - 2.4e-16 59.9 0.1 3.4e-16 59.4 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC47188.1 - 3.9e-16 59.1 0.2 2.1e-15 56.7 0.1 1.8 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 EFC47188.1 - 8.4e-16 58.5 0.0 1.6e-15 57.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC47188.1 - 4.7e-15 56.0 0.0 8.1e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC47188.1 - 2.3e-11 43.8 0.0 3e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC47188.1 - 1.9e-07 31.8 0.1 2.9e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFC47188.1 - 2.5e-06 27.6 0.0 3.7e-06 27.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 EFC47188.1 - 6.4e-05 22.6 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 EFC47188.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PhoLip_ATPase_C PF16212.5 EFC47189.1 - 8.7e-86 287.7 25.5 8.7e-86 287.7 25.5 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC47189.1 - 4.7e-19 67.8 1.9 4.7e-19 67.8 1.9 3.1 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 EFC47189.1 - 2.3e-15 56.4 0.1 3.6e-14 52.6 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 EFC47189.1 - 7.3e-11 41.9 0.0 2.6e-10 40.1 0.0 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 EFC47189.1 - 2.9e-10 40.8 3.7 1.9e-05 25.1 2.4 3.1 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC47189.1 - 0.00081 19.2 0.2 0.0024 17.6 0.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SF3b1 PF08920.10 EFC47190.1 - 1.1e-23 84.0 0.7 3.6e-23 82.3 0.2 2.0 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT PF02985.22 EFC47190.1 - 4.2e-14 51.4 0.3 0.8 10.1 0.0 8.1 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 EFC47190.1 - 2.5e-09 37.4 0.3 0.51 10.8 0.0 6.8 3 2 2 6 6 6 1 HEAT repeats Cnd1 PF12717.7 EFC47190.1 - 4.4e-09 36.6 7.3 0.00074 19.6 0.0 5.7 5 2 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 EFC47190.1 - 2e-08 34.3 7.7 0.00033 20.6 0.1 6.5 6 2 1 8 8 8 2 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 EFC47190.1 - 3.1e-06 27.7 4.1 0.48 11.1 0.0 6.2 5 2 2 7 7 7 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 EFC47190.1 - 0.00071 18.8 3.1 0.57 9.2 0.3 3.6 1 1 1 3 3 3 1 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 EFC47190.1 - 0.00092 19.7 0.0 25 5.5 0.0 6.2 7 1 0 7 7 7 0 HEAT-like repeat MMS19_N PF14500.6 EFC47190.1 - 0.0015 18.1 0.5 1.7 8.2 0.0 3.5 4 0 0 4 4 4 2 Dos2-interacting transcription regulator of RNA-Pol-II HMD PF03201.16 EFC47190.1 - 0.0028 17.9 0.3 0.64 10.3 0.0 3.9 2 1 1 3 3 3 1 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase NopRA1 PF16201.5 EFC47190.1 - 0.0046 16.6 0.9 8.7 5.9 0.0 4.1 4 1 0 4 4 4 2 Nucleolar pre-ribosomal-associated protein 1 NUC173 PF08161.12 EFC47190.1 - 0.091 12.4 1.5 9.3 5.9 0.0 4.7 4 1 0 5 5 5 0 NUC173 domain DRIM PF07539.12 EFC47190.1 - 0.88 7.8 3.9 5.9 5.1 0.1 3.4 2 1 0 3 3 3 0 Down-regulated in metastasis Cnd1 PF12717.7 EFC47191.1 - 0.19 11.8 2.5 1.3 9.0 0.2 2.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 WD40 PF00400.32 EFC47192.1 - 2.6e-14 53.4 18.5 0.00047 20.9 0.0 9.3 11 0 0 11 11 11 4 WD domain, G-beta repeat EF-hand_8 PF13833.6 EFC47192.1 - 0.00032 20.5 0.1 0.00086 19.1 0.1 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 EFC47192.1 - 0.0011 19.4 3.3 0.0012 19.3 0.6 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 EFC47192.1 - 0.0082 15.6 0.1 0.056 13.0 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 EFC47192.1 - 0.012 15.1 0.0 0.04 13.4 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 EFC47192.1 - 0.015 15.2 0.1 0.12 12.4 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain EF-hand_7 PF13499.6 EFC47194.1 - 2.6e-20 72.7 16.6 6.2e-10 39.4 2.4 2.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC47194.1 - 1.3e-13 49.7 4.5 0.0036 17.1 0.2 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 EFC47194.1 - 1.5e-13 49.2 2.6 0.00045 19.6 0.2 4.1 3 1 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 EFC47194.1 - 3.3e-08 33.3 5.2 0.0093 15.8 0.1 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 EFC47194.1 - 3.7e-08 32.5 5.1 0.021 14.3 0.4 4.1 4 1 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 EFC47194.1 - 0.00013 21.8 1.6 0.97 9.4 0.1 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC47194.1 - 0.00045 20.5 4.0 0.48 10.8 0.1 3.2 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region DSPc PF00782.20 EFC47195.1 - 1.6e-18 66.8 0.9 1.5e-16 60.4 0.3 2.8 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PPR_2 PF13041.6 EFC47196.1 - 0.00015 21.9 0.3 15 5.9 0.0 4.2 4 0 0 4 4 4 3 PPR repeat family PPR_3 PF13812.6 EFC47196.1 - 0.041 13.9 0.7 11 6.2 0.1 3.4 2 0 0 2 2 2 0 Pentatricopeptide repeat domain COMPASS-Shg1 PF05205.12 EFC47196.1 - 0.05 14.3 0.6 0.05 14.3 0.6 3.5 3 2 1 4 4 4 0 COMPASS (Complex proteins associated with Set1p) component shg1 MRP-L47 PF06984.13 EFC47197.1 - 1.5e-23 82.7 0.4 2.2e-23 82.2 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 EFC47197.1 - 9.1e-08 32.0 0.9 1.6e-07 31.2 0.9 1.4 1 0 0 1 1 1 1 Ribosomal L29 protein AAA PF00004.29 EFC47198.1 - 5.8e-39 133.5 0.0 9.6e-39 132.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC47198.1 - 3.4e-07 30.8 0.0 3.7e-05 24.2 0.0 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_lid_3 PF17862.1 EFC47198.1 - 3.8e-07 29.8 0.4 8.9e-07 28.6 0.4 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 EFC47198.1 - 8.7e-06 25.8 0.0 1.2e-05 25.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 EFC47198.1 - 2.3e-05 24.2 0.0 0.0065 16.2 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC47198.1 - 4.6e-05 23.4 0.1 0.00034 20.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC47198.1 - 0.0001 22.6 0.6 0.0018 18.5 0.2 2.3 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 EFC47198.1 - 0.00035 21.1 0.0 0.00052 20.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 EFC47198.1 - 0.00084 19.5 0.0 0.002 18.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 EFC47198.1 - 0.0027 17.5 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 EFC47198.1 - 0.0042 16.3 0.0 0.0085 15.3 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 EFC47198.1 - 0.0047 16.7 0.0 0.008 15.9 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 EFC47198.1 - 0.0052 17.1 0.0 0.012 16.0 0.0 1.6 1 1 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 EFC47198.1 - 0.0093 16.2 0.1 0.022 15.0 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFC47198.1 - 0.0097 15.5 0.1 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFC47198.1 - 0.015 14.5 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_33 PF13671.6 EFC47198.1 - 0.015 15.4 0.1 0.022 14.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 EFC47198.1 - 0.022 14.6 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFC47198.1 - 0.037 13.9 0.1 0.12 12.2 0.1 1.8 1 1 1 2 2 2 0 NACHT domain TsaE PF02367.17 EFC47198.1 - 0.056 13.5 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_13 PF13166.6 EFC47198.1 - 0.093 11.4 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_8 PF12780.7 EFC47198.1 - 0.11 11.8 0.0 0.4 10.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 AAA_7 PF12775.7 EFC47198.1 - 0.11 12.0 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 EFC47198.1 - 0.21 11.2 0.2 0.55 9.8 0.1 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 EFC47198.1 - 0.28 11.5 0.6 0.89 9.9 0.3 1.8 1 1 0 2 2 2 0 AAA domain Y_phosphatase2 PF03162.13 EFC47199.1 - 1.7e-42 144.8 0.1 2.1e-42 144.5 0.1 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 EFC47199.1 - 0.0082 15.7 0.0 0.0099 15.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFC47199.1 - 0.035 14.1 0.0 0.08 12.9 0.0 1.7 1 1 0 1 1 1 0 Tyrosine phosphatase family DUF3173 PF11372.8 EFC47199.1 - 0.14 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3173) INO80_Ies4 PF08193.11 EFC47200.1 - 0.0028 17.7 7.2 0.0028 17.7 7.2 5.6 3 2 2 5 5 5 1 INO80 complex subunit Ies4 PAS_10 PF13596.6 EFC47201.1 - 0.12 13.0 5.3 1.1 9.9 0.2 3.8 3 0 0 3 3 3 0 PAS domain DUF2756 PF10956.8 EFC47201.1 - 0.47 11.0 5.1 3.9 8.0 5.1 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) CRM1_C PF08767.11 EFC47202.1 - 9.7e-107 356.8 10.7 9.7e-107 356.8 10.7 3.4 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 EFC47202.1 - 3.1e-34 118.2 7.0 3.1e-34 118.2 7.0 5.0 4 2 1 5 5 5 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 EFC47202.1 - 9.4e-33 111.7 3.2 3e-32 110.1 3.2 2.0 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 EFC47202.1 - 1.5e-28 98.6 2.1 2.7e-28 97.8 0.3 2.6 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 EFC47202.1 - 2.9e-17 61.9 2.2 8.4e-17 60.4 2.2 1.9 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 EFC47202.1 - 7.3e-13 48.2 0.3 7.3e-13 48.2 0.3 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cnd1 PF12717.7 EFC47202.1 - 0.037 14.1 0.1 0.037 14.1 0.1 4.5 4 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 DUF2115 PF09888.9 EFC47202.1 - 0.067 13.7 1.7 0.26 11.8 0.9 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Vac14_Fab1_bd PF12755.7 EFC47202.1 - 0.44 11.2 3.3 81 3.9 0.0 4.8 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region F-box-like PF12937.7 EFC47203.1 - 9.4e-05 22.2 0.1 0.0002 21.2 0.1 1.5 1 0 0 1 1 1 1 F-box-like PMC2NT PF08066.12 EFC47203.1 - 0.06 14.0 0.3 3.3 8.5 0.0 3.3 3 0 0 3 3 3 0 PMC2NT (NUC016) domain Peptidase_S76 PF13611.6 EFC47203.1 - 0.08 13.3 0.2 0.26 11.6 0.1 1.8 2 0 0 2 2 2 0 Serine peptidase of plant viral polyprotein, P1 Pkinase PF00069.25 EFC47204.1 - 2.8e-66 223.6 0.0 3.5e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47204.1 - 5.2e-48 163.6 0.0 7.1e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC47204.1 - 8.6e-07 28.5 0.0 1.6e-05 24.4 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC47204.1 - 0.00093 18.2 0.0 0.0029 16.6 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC47204.1 - 0.0026 17.1 0.0 0.0051 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC47204.1 - 0.022 14.7 0.1 0.065 13.1 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Glyco_transf_18 PF15024.6 EFC47205.1 - 3.9e-10 39.0 8.0 6.1e-10 38.3 8.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 18 Glyco_transf_54 PF04666.13 EFC47205.1 - 3.1e-05 23.0 0.6 5.5e-05 22.2 0.6 1.4 1 0 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region AKAP7_NLS PF10469.9 EFC47205.1 - 0.074 12.9 0.2 0.12 12.2 0.2 1.3 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain UQ_con PF00179.26 EFC47206.1 - 1e-34 119.2 0.0 1.2e-34 119.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC47206.1 - 0.1 12.3 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Myb_DNA-binding PF00249.31 EFC47207.1 - 1.5e-05 25.1 0.7 5.1e-05 23.4 0.7 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC47207.1 - 0.0059 16.8 0.9 0.019 15.2 0.9 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SPT6_acidic PF14632.6 EFC47207.1 - 0.069 13.7 31.0 0.13 12.9 9.8 2.7 2 1 0 2 2 2 0 Acidic N-terminal SPT6 CDC27 PF09507.10 EFC47207.1 - 0.46 9.8 38.6 0.62 9.4 38.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RhoGEF PF00621.20 EFC47208.1 - 5.9e-31 108.1 2.2 5.9e-31 108.1 2.2 3.6 5 1 0 5 5 5 1 RhoGEF domain DUF4461 PF14688.6 EFC47208.1 - 9e-10 38.8 0.1 3e-08 33.8 0.0 3.0 2 1 0 2 2 2 1 Domain of unknown function (DUF4461) Ribosomal_L17 PF01196.19 EFC47208.1 - 3.9e-05 24.5 1.8 0.42 11.6 0.0 3.8 3 0 0 3 3 3 2 Ribosomal protein L17 PH_3 PF14593.6 EFC47208.1 - 0.00035 20.6 0.2 0.032 14.3 0.0 3.2 2 0 0 2 2 2 1 PH domain Gln-synt_C-ter PF18318.1 EFC47208.1 - 0.0055 16.6 0.2 0.038 13.8 0.2 2.5 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain DUF4116 PF13475.6 EFC47209.1 - 4.6e-68 224.8 15.4 1.7e-14 53.2 0.0 8.4 5 3 2 8 8 8 8 Domain of unknown function (DUF4116) DUF2996 PF11210.8 EFC47209.1 - 0.058 13.8 1.1 2.8 8.4 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2996) L51_S25_CI-B8 PF05047.16 EFC47211.1 - 0.073 13.0 0.1 0.12 12.3 0.1 1.6 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain tRNA-synt_1 PF00133.22 EFC47212.1 - 7.9e-214 711.3 1.5 9e-214 711.2 0.5 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 EFC47212.1 - 4.2e-28 98.2 0.6 1.3e-27 96.6 0.6 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 EFC47212.1 - 3e-13 49.3 2.6 0.0019 17.0 0.0 4.0 3 1 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFC47212.1 - 0.013 14.9 0.0 0.064 12.6 0.0 2.2 2 1 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain OmpH PF03938.14 EFC47213.1 - 0.086 13.2 20.4 1.1 9.6 2.8 2.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) GAF PF01590.26 EFC47213.1 - 0.11 13.1 0.0 0.23 12.1 0.0 1.5 1 0 0 1 1 1 0 GAF domain FliD_N PF02465.18 EFC47213.1 - 2.9 8.6 8.2 2.3 9.0 0.5 3.5 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Prefoldin_2 PF01920.20 EFC47213.1 - 5.5 7.0 14.9 2.3 8.2 2.4 3.5 2 1 1 3 3 3 0 Prefoldin subunit BCAS2 PF05700.11 EFC47213.1 - 8.8 6.0 15.8 1.1 8.9 0.3 3.5 3 1 1 4 4 4 0 Breast carcinoma amplified sequence 2 (BCAS2) bZIP_1 PF00170.21 EFC47213.1 - 9 6.5 12.2 5.5 7.2 0.7 3.5 2 2 1 3 3 3 0 bZIP transcription factor F-box-like PF12937.7 EFC47214.1 - 2.7e-05 24.0 0.2 6e-05 22.9 0.2 1.6 1 0 0 1 1 1 1 F-box-like Tmemb_185A PF10269.9 EFC47214.1 - 6.8e-05 22.7 24.7 0.0003 20.6 10.2 2.9 2 1 0 2 2 2 2 Transmembrane Fragile-X-F protein F-box PF00646.33 EFC47214.1 - 0.36 10.8 3.3 6.2 6.8 3.3 2.4 1 1 0 1 1 1 0 F-box domain DUF4598 PF15370.6 EFC47215.1 - 1.7e-14 54.2 10.5 1.7e-14 54.2 10.5 2.7 2 1 1 3 3 3 1 Domain of unknown function (DUF4598) Pex2_Pex12 PF04757.14 EFC47216.1 - 4.3e-40 137.7 11.7 5.1e-40 137.4 11.7 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 EFC47216.1 - 2e-05 24.3 3.4 3.9e-05 23.4 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC47216.1 - 6.2e-05 22.8 5.2 9.9e-05 22.1 5.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC47216.1 - 0.021 14.7 4.2 0.043 13.7 4.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC47216.1 - 0.03 14.7 7.2 0.11 12.9 6.1 2.4 2 1 1 3 3 3 0 Ring finger domain zf-RING_UBOX PF13445.6 EFC47216.1 - 0.16 12.1 5.1 0.32 11.1 5.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Cys_rich_KTR PF14205.6 EFC47216.1 - 0.7 9.7 4.1 2.3 8.1 4.1 1.8 1 1 0 1 1 1 0 Cysteine-rich KTR Prok-RING_4 PF14447.6 EFC47216.1 - 2.5 8.0 8.8 17 5.4 8.6 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Rhodanese PF00581.20 EFC47217.1 - 3e-11 43.8 0.0 3.9e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain tRNA-synt_1 PF00133.22 EFC47218.1 - 7.2e-62 209.5 11.0 3.3e-42 144.6 9.4 6.0 3 1 0 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 EFC47218.1 - 2.7e-60 203.1 0.3 4.3e-60 202.4 0.3 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 EFC47218.1 - 3.2e-29 101.9 0.7 1.5e-19 70.1 0.0 4.2 3 1 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 EFC47218.1 - 5.3e-07 29.3 0.3 0.0095 15.3 0.0 3.0 4 0 0 4 4 4 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1d PF00750.19 EFC47218.1 - 0.0053 15.7 0.0 0.0089 15.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) tRNA-synt_1c PF00749.21 EFC47218.1 - 0.11 11.4 0.4 2.5 6.9 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Fe_hyd_lg_C PF02906.14 EFC47219.1 - 1.7e-56 191.6 0.1 3.4e-56 190.6 0.0 1.5 2 0 0 2 2 2 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 EFC47219.1 - 0.0027 17.8 0.2 0.0059 16.7 0.2 1.6 1 0 0 1 1 1 1 Iron hydrogenase small subunit Cytochrom_NNT PF03264.14 EFC47221.1 - 0.0084 15.8 7.7 0.16 11.7 2.1 2.1 2 0 0 2 2 2 2 NapC/NirT cytochrome c family, N-terminal region Cytochrome_C7 PF14522.6 EFC47221.1 - 0.035 14.1 8.5 2.4 8.2 2.3 3.1 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c HNH PF01844.23 EFC47221.1 - 0.25 11.5 18.7 0.42 10.8 0.2 4.5 5 0 0 5 5 5 0 HNH endonuclease Zn-ribbon_8 PF09723.10 EFC47221.1 - 1.8 8.8 5.7 12 6.1 0.2 3.2 3 0 0 3 3 3 0 Zinc ribbon domain Peptidase_C26 PF07722.13 EFC47222.1 - 8.7e-17 61.6 0.0 9.8e-16 58.2 0.0 2.5 1 1 0 1 1 1 1 Peptidase C26 GATase PF00117.28 EFC47222.1 - 1.7e-09 37.7 0.0 3.1e-09 36.9 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferase class-I EF-hand_6 PF13405.6 EFC47224.1 - 1.8e-10 39.8 13.9 0.08 12.9 0.1 6.0 5 0 0 5 5 5 4 EF-hand domain EF-hand_7 PF13499.6 EFC47224.1 - 2.3e-08 34.3 11.4 0.0003 21.2 0.7 4.3 2 1 2 4 4 4 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC47224.1 - 1.6e-07 30.4 9.9 0.35 10.5 0.2 6.4 6 0 0 6 6 6 3 EF hand EF-hand_5 PF13202.6 EFC47224.1 - 3.3e-05 23.2 2.8 0.11 12.1 0.1 4.2 4 0 0 4 4 4 1 EF hand EF-hand_13 PF17958.1 EFC47224.1 - 0.00096 18.9 0.2 0.0049 16.6 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain Toxin_ToxA PF11584.8 EFC47224.1 - 0.14 12.2 0.1 0.33 11.0 0.1 1.7 1 1 0 1 1 1 0 Proteinaceous host-selective toxin ToxA EF-hand_8 PF13833.6 EFC47224.1 - 1.1 9.2 8.3 29 4.6 0.0 4.7 5 0 0 5 5 5 0 EF-hand domain pair Zn_clus PF00172.18 EFC47225.1 - 4.9e-07 29.8 11.0 9.1e-07 28.9 11.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 3HCDH_N PF02737.18 EFC47226.1 - 2.6e-46 157.8 0.8 3.6e-46 157.3 0.8 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 EFC47226.1 - 1.1e-36 125.3 0.0 4e-36 123.5 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Flu_PB1 PF00602.17 EFC47226.1 - 0.022 12.9 0.1 0.029 12.5 0.1 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 Phage_XkdX PF09693.10 EFC47226.1 - 0.042 13.9 0.0 0.21 11.6 0.1 2.1 2 0 0 2 2 2 0 Phage uncharacterised protein (Phage_XkdX) DUF2680 PF10925.8 EFC47226.1 - 0.11 12.5 0.3 0.56 10.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) TPR_1 PF00515.28 EFC47227.1 - 9.5e-47 155.0 59.5 5.1e-08 32.4 0.1 15.4 16 0 0 16 16 16 10 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47227.1 - 1.3e-44 146.8 52.8 2.1e-07 30.5 0.0 15.4 17 0 0 17 17 16 9 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47227.1 - 3e-42 139.3 41.2 0.0001 22.2 0.0 13.6 13 0 0 13 13 12 9 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47227.1 - 3.9e-38 129.8 17.0 2.7e-07 31.0 0.0 10.6 7 2 5 12 12 12 7 Tetratricopeptide repeat TPR_14 PF13428.6 EFC47227.1 - 2.9e-33 111.7 0.1 0.00038 21.0 0.0 12.2 7 4 6 13 13 13 6 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47227.1 - 9.6e-33 112.3 18.8 2.7e-05 24.4 0.3 9.2 5 3 3 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47227.1 - 1.3e-26 92.9 0.0 3e-06 27.8 0.0 9.5 5 1 7 12 12 12 7 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47227.1 - 8.1e-23 78.7 18.8 0.016 15.2 0.0 11.3 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_6 PF13174.6 EFC47227.1 - 1.8e-20 72.1 16.9 0.0016 19.0 0.0 12.5 14 0 0 14 14 13 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC47227.1 - 1.5e-19 68.9 35.4 0.0018 18.5 0.1 14.7 16 0 0 16 16 14 4 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47227.1 - 3.3e-18 65.1 41.8 3.3e-06 26.7 0.2 13.0 11 4 4 15 15 15 4 TPR repeat TPR_9 PF13371.6 EFC47227.1 - 4.8e-18 65.1 0.0 0.00023 21.2 0.0 5.4 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFC47227.1 - 1.1e-14 53.8 18.9 0.0015 18.3 0.1 10.9 11 0 0 11 11 11 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC47227.1 - 1.9e-13 50.4 34.1 2.3e-05 24.5 2.2 7.2 6 2 2 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 EFC47227.1 - 4.2e-09 36.3 25.3 0.0053 16.8 0.0 9.4 8 1 1 9 9 9 2 Fis1 C-terminal tetratricopeptide repeat PknG_TPR PF16918.5 EFC47227.1 - 8.1e-07 28.1 0.0 0.11 11.2 0.0 3.7 3 1 0 3 3 3 3 Protein kinase G tetratricopeptide repeat TPR_MalT PF17874.1 EFC47227.1 - 1.7e-05 24.4 7.6 0.43 9.9 0.0 4.7 4 1 2 6 6 6 2 MalT-like TPR region TPR_4 PF07721.14 EFC47227.1 - 0.002 18.6 0.5 6.4 7.7 0.0 5.1 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 EFC47227.1 - 0.019 15.3 14.8 0.07 13.5 0.2 7.3 8 2 2 10 10 9 0 Tetratricopeptide repeat TPPII_N PF12583.8 EFC47227.1 - 0.026 15.1 10.1 0.71 10.4 0.1 4.3 4 0 0 4 4 4 0 Tripeptidyl peptidase II N terminal SHNi-TPR PF10516.9 EFC47227.1 - 0.35 10.4 3.9 89 2.7 0.2 5.0 6 0 0 6 6 5 0 SHNi-TPR CDC27 PF09507.10 EFC47227.1 - 0.89 8.9 49.9 1.4 8.2 49.9 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Tubulin PF00091.25 EFC47228.1 - 1.3e-68 231.1 0.0 3e-68 229.9 0.0 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC47228.1 - 2e-44 150.8 0.6 4.2e-44 149.7 0.6 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 EFC47228.1 - 3.1e-05 24.3 0.1 0.00042 20.6 0.1 2.4 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFC47228.1 - 0.011 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 EFC47228.1 - 0.021 14.0 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Pro_isomerase PF00160.21 EFC47229.1 - 1e-50 172.1 0.0 1.2e-50 171.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PPR PF01535.20 EFC47230.1 - 1e-27 94.4 10.9 6e-06 26.1 0.0 6.1 6 0 0 6 6 6 6 PPR repeat PPR_2 PF13041.6 EFC47230.1 - 2.1e-27 95.0 7.6 9.9e-12 44.9 0.0 5.0 3 2 2 5 5 5 4 PPR repeat family PPR_3 PF13812.6 EFC47230.1 - 6.5e-16 58.2 3.8 0.001 19.1 0.2 4.2 3 1 1 4 4 4 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC47230.1 - 2.5e-14 52.7 2.9 0.011 15.4 0.0 6.0 6 1 0 6 6 6 4 PPR repeat PPR_long PF17177.4 EFC47230.1 - 3.8e-07 29.7 0.0 0.00076 18.9 0.0 2.1 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP FERM_M PF00373.18 EFC47231.1 - 3.4e-21 75.9 0.0 1.3e-20 74.0 0.0 2.0 2 0 0 2 2 2 1 FERM central domain LRR_6 PF13516.6 EFC47231.1 - 2.8e-17 61.2 50.7 0.0098 15.9 0.1 14.1 15 0 0 15 15 15 7 Leucine Rich repeat FERM_N PF09379.10 EFC47231.1 - 1.3e-10 41.0 0.1 8.4e-10 38.5 0.0 2.4 2 0 0 2 2 2 1 FERM N-terminal domain LRR_4 PF12799.7 EFC47231.1 - 9.4e-05 22.7 51.0 0.61 10.6 0.9 9.6 5 3 4 10 10 10 5 Leucine Rich repeats (2 copies) Rad60-SLD PF11976.8 EFC47231.1 - 0.023 14.5 0.1 0.091 12.6 0.1 2.1 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like LRR_1 PF00560.33 EFC47231.1 - 0.024 15.1 28.4 20 6.2 0.1 11.0 11 1 0 11 11 11 0 Leucine Rich Repeat SPX PF03105.19 EFC47232.1 - 2.9e-23 83.4 11.1 3.3e-12 47.1 0.4 6.0 3 2 2 5 5 5 3 SPX domain SNAPc_SNAP43 PF09808.9 EFC47232.1 - 1.2e-17 64.4 1.1 1.2e-17 64.4 1.1 3.6 2 1 0 2 2 2 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 WD40 PF00400.32 EFC47233.1 - 1.7e-32 110.9 15.0 3e-07 31.0 0.2 6.9 7 0 0 7 7 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47233.1 - 8.3e-17 61.3 0.0 0.00027 21.2 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC47233.1 - 6.9e-07 29.3 1.0 0.014 15.3 0.1 3.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 EFC47233.1 - 1.3e-05 24.0 0.1 0.33 9.4 0.0 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain CSTF1_dimer PF16699.5 EFC47233.1 - 0.00084 19.1 0.1 0.0077 16.0 0.0 2.4 2 0 0 2 2 2 1 Cleavage stimulation factor subunit 1, dimerisation domain Frtz PF11768.8 EFC47233.1 - 0.0019 16.6 0.3 3.8 5.7 0.1 3.5 2 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 EFC47233.1 - 0.0021 17.4 0.3 0.36 10.1 0.0 3.1 3 1 0 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 EFC47233.1 - 0.0067 15.4 0.3 4.6 6.1 0.1 3.0 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein APG5 PF04106.12 EFC47233.1 - 0.015 14.9 0.7 0.024 14.2 0.7 1.3 1 0 0 1 1 1 0 Autophagy protein Apg5 DUF5121 PF17165.4 EFC47233.1 - 0.088 13.2 0.6 1.2 9.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5121) PD40 PF07676.12 EFC47233.1 - 0.093 12.7 0.0 25 4.9 0.0 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 EFC47233.1 - 0.13 12.3 0.0 4 7.5 0.0 2.8 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF4541 PF15074.6 EFC47233.1 - 0.25 11.9 0.0 0.25 11.9 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4541) Peptidase_S8 PF00082.22 EFC47234.1 - 9.5e-20 71.0 1.2 9.5e-20 71.0 1.2 2.2 1 1 0 1 1 1 1 Subtilase family Adeno_E3_CR2 PF02439.15 EFC47234.1 - 2 8.3 8.8 8.3 6.3 8.8 2.1 1 1 0 1 1 1 0 Adenovirus E3 region protein CR2 Asn_synthase PF00733.21 EFC47235.1 - 1.5e-11 44.6 4.7 3e-05 23.9 0.1 3.9 2 1 1 3 3 3 2 Asparagine synthase GATase_7 PF13537.6 EFC47235.1 - 4.7e-10 39.4 0.0 7.6e-08 32.3 0.0 2.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFC47235.1 - 8.6e-05 22.7 0.0 0.00019 21.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain WW PF00397.26 EFC47235.1 - 0.025 14.7 0.3 0.025 14.7 0.3 2.6 3 0 0 3 3 3 0 WW domain DUF4710 PF15828.5 EFC47235.1 - 1.1 9.4 9.8 0.25 11.5 0.1 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) WD40 PF00400.32 EFC47236.1 - 2.5e-40 135.7 25.3 6e-06 26.9 0.0 12.3 13 0 0 13 13 13 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47236.1 - 9.5e-17 61.1 9.2 0.18 12.1 0.1 9.3 2 2 7 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 EFC47236.1 - 1.6e-12 47.7 2.5 4.1e-12 46.3 2.5 1.8 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 EFC47236.1 - 1.3e-06 28.0 23.1 0.0039 16.6 0.2 5.1 4 1 1 5 5 5 3 WD40-like domain PALB2_WD40 PF16756.5 EFC47236.1 - 5.6e-05 22.2 1.3 0.19 10.6 0.1 3.9 3 1 0 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 EFC47236.1 - 0.00049 19.0 12.9 0.0014 17.4 0.7 4.6 3 2 0 3 3 3 1 Nup133 N terminal like Ge1_WD40 PF16529.5 EFC47236.1 - 0.0025 16.8 12.8 0.058 12.3 0.0 6.0 2 2 2 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_N PF14781.6 EFC47236.1 - 0.0073 16.2 0.2 0.78 9.7 0.0 4.0 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, N-terminal AAA_18 PF13238.6 EFC47238.1 - 0.00064 20.3 0.0 0.0011 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 EFC47238.1 - 0.0038 17.0 0.0 0.013 15.2 0.0 1.7 1 1 0 2 2 2 1 Cytidylate kinase AAA_33 PF13671.6 EFC47238.1 - 0.0077 16.4 0.0 0.011 15.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 EFC47238.1 - 0.013 15.2 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Dephospho-CoA kinase SRA PF18491.1 EFC47238.1 - 0.049 13.7 0.1 0.096 12.8 0.0 1.4 2 0 0 2 2 2 0 SET and RING associated domain SKI PF01202.22 EFC47238.1 - 0.05 13.7 0.0 0.074 13.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate kinase Zeta_toxin PF06414.12 EFC47238.1 - 0.051 12.8 0.0 0.072 12.4 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin2 PF13189.6 EFC47238.1 - 0.15 12.1 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase-like family MFS_1 PF07690.16 EFC47239.1 - 8.5e-44 149.9 21.7 8.5e-44 149.9 21.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 EFC47239.1 - 1.5e-26 92.9 23.8 6.4e-22 77.6 2.2 4.7 2 1 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family DUF498 PF04430.14 EFC47239.1 - 8.4e-26 90.2 0.0 1.6e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Sugar_tr PF00083.24 EFC47239.1 - 4.2e-18 65.4 22.1 1.5e-17 63.6 22.1 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter SieB PF14163.6 EFC47239.1 - 0.11 12.0 2.0 0.47 9.9 0.1 2.9 3 0 0 3 3 3 0 Super-infection exclusion protein B Gp5_OB PF06714.11 EFC47239.1 - 1.2 9.3 3.6 5.5 7.2 1.7 2.5 2 0 0 2 2 2 0 Gp5 N-terminal OB domain Ax_dynein_light PF10211.9 EFC47240.1 - 7.3e-09 35.8 6.2 7.3e-09 35.8 6.2 3.3 3 0 0 3 3 3 1 Axonemal dynein light chain SHOCT PF09851.9 EFC47240.1 - 3.3e-08 33.0 3.5 1.3e-07 31.1 3.5 2.2 1 0 0 1 1 1 1 Short C-terminal domain CI-B14_5a PF07347.12 EFC47241.1 - 0.039 13.8 0.2 0.083 12.8 0.2 1.6 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Foie-gras_1 PF11817.8 EFC47242.1 - 1.8e-08 34.3 0.0 3.7e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Foie gras liver health family 1 TRAPPC10 PF12584.8 EFC47242.1 - 1.6e-05 24.7 0.0 4.9e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 BRCA-2_OB1 PF09103.10 EFC47242.1 - 0.04 13.9 0.6 0.094 12.7 0.0 1.9 2 0 0 2 2 2 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 zf-C3H2C3 PF17122.5 EFC47243.1 - 3.1e-08 33.5 9.1 5.3e-08 32.8 9.1 1.4 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 EFC47243.1 - 0.059 13.2 10.6 0.11 12.3 10.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 EFC47243.1 - 0.061 13.6 0.1 0.46 10.8 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPM_phosphatase PF04536.14 EFC47243.1 - 0.062 13.5 0.0 0.27 11.4 0.0 2.1 1 0 0 1 1 1 0 TPM domain DivIC PF04977.15 EFC47243.1 - 0.32 10.8 4.4 1 9.2 4.4 1.8 1 0 0 1 1 1 0 Septum formation initiator zf-RING_UBOX PF13445.6 EFC47243.1 - 0.49 10.5 6.5 1.1 9.4 6.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_2 PF13639.6 EFC47243.1 - 0.78 10.1 9.3 1.6 9.2 9.3 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 EFC47243.1 - 4.9 7.2 8.7 10 6.1 8.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain SPC22 PF04573.12 EFC47244.1 - 2.5e-44 150.8 0.2 3e-44 150.5 0.2 1.1 1 0 0 1 1 1 1 Signal peptidase subunit Ras PF00071.22 EFC47245.1 - 2.5e-40 137.7 0.4 2.5e-40 137.7 0.4 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.13 EFC47245.1 - 2.4e-26 92.3 1.4 4.9e-26 91.3 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47245.1 - 1.2e-11 44.4 0.1 1.2e-11 44.4 0.1 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC47245.1 - 1.6e-06 28.2 1.4 2.3e-06 27.7 0.1 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC47245.1 - 0.00015 21.2 0.3 0.00026 20.4 0.3 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC47245.1 - 0.00064 19.3 0.1 0.00064 19.3 0.1 2.7 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 EFC47245.1 - 0.012 14.8 0.6 0.032 13.4 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 EFC47245.1 - 0.013 15.9 0.1 0.043 14.2 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFC47245.1 - 0.017 15.7 0.2 0.072 13.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 EFC47245.1 - 0.017 14.8 0.1 0.05 13.3 0.1 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 EFC47245.1 - 0.018 14.7 0.2 0.062 13.0 0.0 1.9 2 1 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 EFC47245.1 - 0.02 14.9 0.0 0.045 13.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFC47245.1 - 0.023 14.2 1.3 0.031 13.8 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 EFC47245.1 - 0.023 14.9 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC47245.1 - 0.026 14.9 0.0 0.04 14.3 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 EFC47245.1 - 0.028 14.4 0.1 0.064 13.2 0.1 1.6 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 EFC47245.1 - 0.036 14.1 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 EFC47245.1 - 0.045 13.7 1.0 0.3 11.0 0.1 2.2 2 1 0 2 2 2 0 RsgA GTPase RuvB_N PF05496.12 EFC47245.1 - 0.056 13.2 0.0 0.093 12.5 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Tir_receptor_N PF07490.11 EFC47245.1 - 2.2 8.1 6.0 5.2 6.8 0.0 2.1 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) N-terminus Dna2 PF08696.11 EFC47246.1 - 0.05 13.4 0.3 0.051 13.4 0.3 1.3 1 0 0 1 1 1 0 DNA replication factor Dna2 Chrome_Resist PF09828.9 EFC47246.1 - 0.069 13.6 0.1 0.15 12.5 0.0 1.5 2 0 0 2 2 2 0 Chromate resistance exported protein Fib_alpha PF08702.10 EFC47247.1 - 0.35 11.1 48.6 0.08 13.1 5.5 4.3 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family Macoilin PF09726.9 EFC47247.1 - 0.84 8.1 53.3 2.5 6.5 53.3 1.6 1 1 0 1 1 1 0 Macoilin family PspA_IM30 PF04012.12 EFC47247.1 - 3 7.4 34.9 0.091 12.3 23.5 2.4 1 1 1 2 2 2 0 PspA/IM30 family NHL PF01436.21 EFC47248.1 - 5.4e-08 32.5 0.0 1.3e-05 24.9 0.0 3.0 3 0 0 3 3 3 2 NHL repeat Mgm101p PF06420.12 EFC47249.1 - 1.1e-62 210.6 0.0 1.2e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 GDPD PF03009.17 EFC47250.1 - 3.9e-33 115.3 0.0 4.9e-33 115.0 0.0 1.1 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Glycophorin_A PF01102.18 EFC47250.1 - 0.13 12.5 0.4 0.47 10.7 0.1 2.0 2 0 0 2 2 2 0 Glycophorin A HGTP_anticodon PF03129.20 EFC47251.1 - 2.8e-20 72.3 0.1 5.7e-20 71.3 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 EFC47251.1 - 1.6e-14 54.3 0.0 3e-14 53.4 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) PolyA_pol PF01743.20 EFC47252.1 - 5.9e-26 91.4 0.1 2.6e-25 89.3 0.0 2.1 2 0 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 EFC47252.1 - 0.0015 18.3 0.0 0.0041 16.9 0.0 1.8 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A Polysacc_deac_2 PF04748.13 EFC47252.1 - 0.16 11.2 0.0 1 8.5 0.0 2.3 3 0 0 3 3 3 0 Divergent polysaccharide deacetylase GPS2_interact PF15784.5 EFC47254.1 - 0.0028 18.1 1.8 0.0028 18.1 1.8 2.5 3 0 0 3 3 3 1 G-protein pathway suppressor 2-interacting domain NPV_P10 PF05531.12 EFC47254.1 - 0.28 11.7 1.8 0.78 10.2 1.8 1.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Spectrin PF00435.21 EFC47254.1 - 0.38 11.3 3.7 2.6 8.6 3.7 2.1 1 1 0 1 1 1 0 Spectrin repeat Ras PF00071.22 EFC47255.1 - 3.5e-16 59.2 0.5 2.1e-15 56.7 0.5 2.1 1 1 0 1 1 1 1 Ras family F-box-like PF12937.7 EFC47255.1 - 5.8e-09 35.7 0.1 1.2e-08 34.7 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC47255.1 - 1.5e-08 34.3 0.4 4.3e-08 32.8 0.4 1.8 1 0 0 1 1 1 1 F-box domain Roc PF08477.13 EFC47255.1 - 5.4e-07 29.9 0.1 1e-05 25.7 0.1 2.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 EFC47255.1 - 0.0016 18.0 0.0 0.005 16.4 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 EFC47255.1 - 0.003 17.5 0.1 0.39 10.6 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 EFC47255.1 - 0.023 15.0 0.0 0.081 13.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain Filament PF00038.21 EFC47256.1 - 9.9 5.6 39.4 4.8 6.7 36.5 1.9 2 1 0 2 2 2 0 Intermediate filament protein SLATT_4 PF18186.1 EFC47260.1 - 2 8.1 5.1 1.3 8.7 0.1 2.7 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 4 BRCT PF00533.26 EFC47261.1 - 5.3e-10 39.5 1.5 1.4e-08 35.0 0.0 3.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFC47261.1 - 2.9e-09 36.7 0.0 2.9e-09 36.7 0.0 4.2 3 1 2 5 5 5 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 EFC47261.1 - 3.8e-09 36.8 1.6 3.9e-06 27.2 0.0 3.8 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain DUF3584 PF12128.8 EFC47261.1 - 0.00021 19.0 55.5 0.00029 18.6 55.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Golgin_A5 PF09787.9 EFC47261.1 - 0.0015 18.1 48.5 0.0015 18.1 48.5 2.5 1 1 1 2 2 2 1 Golgin subfamily A member 5 DUF2968 PF11180.8 EFC47261.1 - 0.0021 17.7 3.6 0.0021 17.7 3.6 3.7 1 1 3 4 4 4 1 Protein of unknown function (DUF2968) PTCB-BRCT PF12738.7 EFC47261.1 - 0.013 15.5 0.1 0.056 13.4 0.0 2.2 2 0 0 2 2 2 0 twin BRCT domain CALCOCO1 PF07888.11 EFC47261.1 - 4.7 6.0 57.6 1.7 7.4 19.2 2.6 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TPR_MLP1_2 PF07926.12 EFC47261.1 - 7.4 6.6 82.8 0.017 15.2 34.9 4.3 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Filament PF00038.21 EFC47261.1 - 9.3 5.7 63.9 0.78 9.3 32.8 3.2 1 1 2 3 3 3 0 Intermediate filament protein DUF4116 PF13475.6 EFC47262.1 - 7.5e-32 108.8 5.2 1.9e-12 46.7 0.0 4.8 3 1 1 4 4 4 4 Domain of unknown function (DUF4116) eIF-5a PF01287.20 EFC47262.1 - 0.009 16.1 0.1 0.044 13.9 0.1 2.2 2 0 0 2 2 2 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Stress-antifung PF01657.17 EFC47262.1 - 0.016 15.8 0.1 0.043 14.4 0.1 1.7 1 0 0 1 1 1 0 Salt stress response/antifungal RCC1 PF00415.18 EFC47263.1 - 7.1e-48 161.0 1.2 8.3e-11 42.3 0.0 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC47263.1 - 4.2e-33 112.5 9.2 4e-07 29.7 0.1 5.6 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat DUF1924 PF09086.11 EFC47263.1 - 0.1 13.0 0.1 0.67 10.4 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1924) Zn_Tnp_IS1 PF03811.13 EFC47263.1 - 0.28 11.0 1.6 0.36 10.6 0.1 1.9 2 0 0 2 2 2 0 InsA N-terminal domain RCC1 PF00415.18 EFC47264.1 - 9.5e-26 90.2 14.6 0.0013 19.3 0.1 11.3 11 2 0 11 11 11 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC47264.1 - 2.1e-24 84.8 42.4 8.2e-05 22.3 1.2 12.5 12 0 0 12 12 12 7 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC47264.1 - 4.6e-07 30.1 44.9 0.00089 19.6 12.2 3.7 3 0 0 3 3 3 3 EGF-like domain HTH_37 PF13744.6 EFC47265.1 - 0.33 10.9 1.7 0.93 9.5 1.7 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain PMSR PF01625.21 EFC47265.1 - 2.6 8.2 5.0 22 5.2 0.2 2.9 2 0 0 2 2 2 0 Peptide methionine sulfoxide reductase RGS PF00615.19 EFC47266.1 - 0.0005 20.3 2.0 2.3 8.5 0.0 4.1 5 0 0 5 5 5 2 Regulator of G protein signaling domain Ig_mannosidase PF17753.1 EFC47267.1 - 4.9e-05 23.0 0.0 0.00016 21.4 0.0 2.0 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2 PF00703.21 EFC47267.1 - 0.00077 20.1 1.4 0.015 15.9 0.1 3.1 3 0 0 3 3 3 1 Glycosyl hydrolases family 2 Ig_GlcNase PF18368.1 EFC47267.1 - 0.0011 19.0 0.0 0.0061 16.7 0.0 2.1 2 1 0 2 2 2 1 Exo-beta-D-glucosaminidase Ig-fold domain AAA_18 PF13238.6 EFC47267.1 - 0.14 12.7 0.1 0.57 10.7 0.1 2.1 2 0 0 2 2 2 0 AAA domain 4HBT_2 PF13279.6 EFC47268.1 - 1.4e-15 57.8 0.8 1.9e-15 57.4 0.8 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 EFC47268.1 - 9.2e-08 31.7 3.7 2.8e-05 23.6 0.9 2.4 1 1 1 2 2 2 2 Acyl-ACP thioesterase 4HBT PF03061.22 EFC47268.1 - 3e-07 30.7 0.0 4.9e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily ERGIC_N PF13850.6 EFC47269.1 - 0.16 12.4 1.8 0.2 12.0 0.0 2.1 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) RGS PF00615.19 EFC47270.1 - 8e-10 39.0 2.4 8e-10 39.0 2.4 2.4 2 1 0 2 2 2 1 Regulator of G protein signaling domain Ig_C17orf99 PF17736.1 EFC47270.1 - 0.065 13.3 0.5 0.36 10.9 0.3 2.3 2 0 0 2 2 2 0 C17orf99 Ig domain START PF01852.19 EFC47271.1 - 7.6e-05 22.2 0.0 0.031 13.7 0.0 2.1 2 0 0 2 2 2 2 START domain TSP_C PF05735.12 EFC47271.1 - 0.063 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Thrombospondin C-terminal region PAC2 PF09754.9 EFC47272.1 - 3.9e-20 72.8 0.0 7.4e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 PAC2 family Sel1 PF08238.12 EFC47272.1 - 9.8e-20 70.6 4.4 2.4e-07 31.2 0.1 3.5 3 0 0 3 3 3 3 Sel1 repeat Epimerase_2 PF02350.19 EFC47272.1 - 0.16 10.8 0.0 1.5 7.6 0.0 2.0 1 1 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase Phospholip_B PF04916.13 EFC47273.1 - 8.8e-142 473.4 20.9 6.5e-137 457.3 11.0 2.0 1 1 1 2 2 2 2 Phospholipase B Zip PF02535.22 EFC47274.1 - 4.9e-39 134.5 16.9 1.8e-38 132.6 16.9 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter RCC1_2 PF13540.6 EFC47275.1 - 6e-13 48.2 21.6 0.023 14.5 0.0 9.2 9 0 0 9 9 9 5 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC47275.1 - 1.2e-10 41.6 43.7 0.00036 20.8 7.2 4.1 4 0 0 4 4 4 3 EGF-like domain RCC1 PF00415.18 EFC47275.1 - 3.6e-09 37.1 5.2 0.008 16.8 0.0 6.6 8 0 0 8 8 8 2 Regulator of chromosome condensation (RCC1) repeat EGF PF00008.27 EFC47275.1 - 0.0082 16.4 28.5 0.22 11.8 1.7 4.0 4 0 0 4 4 4 3 EGF-like domain EP400_N PF15790.5 EFC47275.1 - 0.056 12.3 0.1 0.092 11.6 0.1 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal fn3_3 PF14686.6 EFC47276.1 - 0.033 14.0 0.9 0.057 13.2 0.1 1.8 2 0 0 2 2 2 0 Polysaccharide lyase family 4, domain II FDX-ACB PF03147.14 EFC47276.1 - 0.12 12.8 0.1 0.24 11.9 0.1 1.4 1 0 0 1 1 1 0 Ferredoxin-fold anticodon binding domain Penicil_amidase PF01804.18 EFC47278.1 - 4.7e-165 551.3 0.0 5.8e-165 551.0 0.0 1.0 1 0 0 1 1 1 1 Penicillin amidase Pex24p PF06398.11 EFC47278.1 - 0.03 13.3 0.3 0.053 12.5 0.3 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Sensor_TM1 PF13755.6 EFC47278.1 - 0.062 13.0 0.0 0.24 11.2 0.1 1.9 2 0 0 2 2 2 0 Sensor N-terminal transmembrane domain RGS PF00615.19 EFC47279.1 - 5.2e-07 30.0 1.2 1.3e-06 28.7 1.2 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain EphA2_TM PF14575.6 EFC47279.1 - 8.2 7.4 0.0 8.2 7.4 0.0 4.1 5 1 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain Ly49 PF08391.10 EFC47279.1 - 8.3 6.8 12.3 0.2 12.0 0.3 3.8 4 0 0 4 4 4 0 Ly49-like protein, N-terminal region Cucumo_coat PF00760.18 EFC47280.1 - 0.076 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Cucumovirus coat protein Phage_integrase PF00589.22 EFC47282.1 - 0.0091 15.8 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Phage integrase family Baculo_LEF5 PF04838.12 EFC47282.1 - 0.083 12.9 0.2 0.17 11.9 0.2 1.5 1 1 0 1 1 1 0 Baculoviridae late expression factor 5 DUF4509 PF14970.6 EFC47283.1 - 0.0023 17.9 0.7 0.0023 17.9 0.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4509) Ank_4 PF13637.6 EFC47284.1 - 1.8e-24 85.8 12.6 7.6e-05 23.2 0.2 8.1 2 2 6 9 9 9 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC47284.1 - 8.1e-24 84.0 16.3 2.6e-09 37.5 0.9 4.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC47284.1 - 2.3e-16 59.6 5.4 2.8e-05 24.3 0.0 4.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC47284.1 - 9.8e-15 53.2 8.2 0.12 13.0 0.0 7.5 8 0 0 8 8 8 4 Ankyrin repeat RGS PF00615.19 EFC47284.1 - 9.4e-13 48.5 6.7 9.4e-13 48.5 6.7 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain Ank PF00023.30 EFC47284.1 - 2.2e-12 46.8 4.2 0.36 11.4 0.0 6.7 6 0 0 6 6 6 4 Ankyrin repeat START PF01852.19 EFC47284.1 - 9.7e-11 41.5 0.2 1.6e-10 40.7 0.2 1.4 1 0 0 1 1 1 1 START domain zinc_ribbon_2 PF13240.6 EFC47284.1 - 0.0062 16.2 1.0 0.0062 16.2 1.0 3.0 3 0 0 3 3 3 1 zinc-ribbon domain CpXC PF14353.6 EFC47284.1 - 0.063 13.3 0.6 8.5 6.5 0.0 3.4 3 0 0 3 3 3 0 CpXC protein zf-ribbon_3 PF13248.6 EFC47284.1 - 0.13 11.7 0.3 0.65 9.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain SNF2_N PF00176.23 EFC47285.1 - 1.9e-72 243.9 3.0 1.9e-72 243.9 3.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 EFC47285.1 - 3e-20 72.1 0.1 3.8e-19 68.5 0.0 2.8 2 0 0 2 2 2 1 Bromodomain Helicase_C PF00271.31 EFC47285.1 - 4e-19 69.0 0.0 2.9e-17 63.0 0.0 3.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain QLQ PF08880.11 EFC47285.1 - 1.1e-09 37.9 0.8 1.1e-09 37.9 0.8 3.7 3 0 0 3 3 3 1 QLQ SnAC PF14619.6 EFC47285.1 - 6.9e-06 26.6 3.3 6.9e-06 26.6 3.3 4.4 3 1 2 5 5 5 1 Snf2-ATP coupling, chromatin remodelling complex nos_propeller_2 PF18793.1 EFC47286.1 - 0.12 12.8 0.2 0.23 11.8 0.2 1.5 1 1 0 1 1 1 0 Nitrous oxide reductase propeller repeat 2 MFS_2 PF13347.6 EFC47287.1 - 1.6e-20 73.1 12.0 1.8e-17 63.0 0.5 2.3 1 1 0 2 2 2 2 MFS/sugar transport protein DUF4408 PF14364.6 EFC47287.1 - 0.65 9.8 7.8 3.6 7.4 1.5 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4408) Pkinase PF00069.25 EFC47288.1 - 6.8e-72 242.0 0.0 8.6e-72 241.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47288.1 - 6.2e-29 101.1 0.0 1.1e-28 100.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC47288.1 - 0.0011 18.0 0.2 0.0023 16.9 0.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFC47288.1 - 0.077 12.3 0.0 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 Kinase-like UPF0182 PF03699.13 EFC47289.1 - 0.028 12.6 0.3 0.028 12.6 0.3 2.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0182) RWP-RK PF02042.15 EFC47290.1 - 6.2e-18 64.5 0.4 1.3e-17 63.5 0.4 1.6 1 0 0 1 1 1 1 RWP-RK domain DEAD PF00270.29 EFC47291.1 - 6.4e-51 172.6 0.0 1.4e-50 171.5 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC47291.1 - 3.9e-32 110.9 0.0 1.8e-31 108.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC47291.1 - 0.00014 21.9 0.0 0.00029 20.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 EFC47291.1 - 0.014 14.2 0.0 0.26 10.0 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 EFC47291.1 - 0.022 14.1 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DFRP_C PF16543.5 EFC47292.1 - 1.3e-19 70.4 5.0 1.3e-19 70.4 5.0 3.4 3 1 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Lipoprotein_2 PF00921.17 EFC47292.1 - 0.0047 16.5 15.2 0.0093 15.6 15.2 1.5 1 0 0 1 1 1 1 Borrelia lipoprotein BUD22 PF09073.10 EFC47292.1 - 0.32 10.3 31.0 0.041 13.2 26.7 1.6 1 1 1 2 2 2 0 BUD22 Methyltrn_RNA_4 PF09936.9 EFC47292.1 - 1.2 9.0 3.8 2.5 7.9 3.8 1.5 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase SBP_bac_3 PF00497.20 EFC47293.1 - 1.1e-12 47.9 0.0 1.9e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 GTP_EFTU PF00009.27 EFC47294.1 - 1.9e-24 86.3 0.2 6.3e-24 84.6 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFC47294.1 - 9.3e-09 35.6 1.2 1.9e-08 34.6 1.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC47294.1 - 0.00011 22.3 0.0 0.00027 21.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC47294.1 - 0.0056 16.1 1.8 0.0085 15.5 0.2 2.1 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit cobW PF02492.19 EFC47294.1 - 0.0067 16.0 0.1 0.018 14.6 0.1 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU_D4 PF14578.6 EFC47294.1 - 0.066 13.1 1.0 0.18 11.7 1.0 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 eIF-3c_N PF05470.12 EFC47295.1 - 1.6e-122 409.8 22.2 5.6e-105 351.9 1.2 4.2 3 1 1 4 4 4 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 EFC47295.1 - 3.8e-11 43.4 0.2 2.8e-10 40.7 0.0 2.7 2 0 0 2 2 2 1 PCI domain Presenilin PF01080.17 EFC47296.1 - 7.5 5.2 5.4 8.3 5.1 5.4 1.0 1 0 0 1 1 1 0 Presenilin zf-Sec23_Sec24 PF04810.15 EFC47297.1 - 0.00084 19.3 0.5 0.042 13.9 0.1 2.2 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger Kinesin PF00225.23 EFC47298.1 - 9.1e-98 327.2 6.7 2.1e-97 326.0 6.7 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC47298.1 - 9.7e-26 90.5 1.3 9.7e-26 90.5 1.3 2.2 2 0 0 2 2 2 1 Microtubule binding Atg14 PF10186.9 EFC47298.1 - 0.0016 17.6 10.5 0.0016 17.6 10.5 2.1 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 EFC47298.1 - 0.007 15.8 6.0 0.007 15.8 6.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) Vac_Fusion PF02346.16 EFC47298.1 - 0.014 15.0 0.2 0.078 12.6 0.2 2.3 1 0 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 ResIII PF04851.15 EFC47298.1 - 0.092 12.7 0.0 0.092 12.7 0.0 2.9 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit Sec3_C_2 PF15278.6 EFC47298.1 - 0.11 12.9 4.2 0.083 13.2 0.6 2.8 2 0 0 2 2 2 0 Sec3 exocyst complex subunit T3SSipB PF16535.5 EFC47298.1 - 0.21 12.1 6.9 4.1 7.9 1.5 3.1 2 1 1 3 3 3 0 Type III cell invasion protein SipB KxDL PF10241.9 EFC47298.1 - 0.47 10.8 12.9 0.17 12.2 2.0 3.5 3 0 0 3 3 3 0 Uncharacterized conserved protein DUF1542 PF07564.11 EFC47298.1 - 1.4 9.1 8.7 0.33 11.1 4.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) BST2 PF16716.5 EFC47298.1 - 1.6 9.4 12.2 4.5 7.9 1.9 4.0 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 BLOC1_2 PF10046.9 EFC47298.1 - 6.7 7.1 12.8 1.2 9.4 0.8 3.9 4 0 0 4 4 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SLAC1 PF03595.17 EFC47300.1 - 0.0038 16.6 1.0 0.0055 16.0 1.0 1.2 1 0 0 1 1 1 1 Voltage-dependent anion channel WD40 PF00400.32 EFC47301.1 - 7.2e-05 23.5 0.9 1.2 10.1 0.0 5.0 5 1 0 5 5 5 2 WD domain, G-beta repeat DnaJ PF00226.31 EFC47302.1 - 4.8e-18 65.0 11.3 3.4e-17 62.3 8.7 2.8 2 1 0 2 2 2 1 DnaJ domain Thy1 PF02511.15 EFC47302.1 - 0.058 13.2 1.5 0.069 13.0 0.9 1.5 1 1 0 1 1 1 0 Thymidylate synthase complementing protein Sterol_MT_C PF08498.10 EFC47303.1 - 3.3e-23 81.8 0.1 5.7e-23 81.0 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 EFC47303.1 - 8.2e-11 42.4 0.0 1.6e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFC47303.1 - 1.2e-10 41.2 0.0 1.6e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFC47303.1 - 1.4e-09 38.0 0.0 3.6e-09 36.7 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC47303.1 - 1e-07 32.6 0.0 2.6e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC47303.1 - 9.4e-07 28.7 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC47303.1 - 2.7e-06 28.0 0.0 2.9e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EFC47303.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TPR_MalT PF17874.1 EFC47304.1 - 0.013 14.8 0.0 0.036 13.4 0.0 1.6 2 0 0 2 2 2 0 MalT-like TPR region TPR_7 PF13176.6 EFC47304.1 - 0.022 14.7 0.0 1 9.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Polyketide_cyc PF03364.20 EFC47305.1 - 1.3e-18 67.4 0.2 1.5e-18 67.2 0.2 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 EFC47305.1 - 0.00073 19.8 0.0 0.00085 19.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF3449 PF11931.8 EFC47306.1 - 5.5e-72 241.4 9.1 5.5e-72 241.4 9.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 EFC47306.1 - 4e-21 75.3 2.4 4e-21 75.3 2.4 2.5 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 EFC47306.1 - 1.4e-06 28.0 0.2 3.1e-06 26.9 0.2 1.6 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain PRP9_N PF16958.5 EFC47306.1 - 0.00031 20.8 5.7 0.00031 20.8 5.7 3.4 3 1 1 4 4 4 2 Pre-mRNA-splicing factor PRP9 N-terminus tRNA-synt_1b PF00579.25 EFC47307.1 - 4.1e-64 216.7 0.1 5.4e-64 216.3 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Thiamine_BP PF01910.17 EFC47307.1 - 0.063 13.2 0.4 0.19 11.6 0.4 1.8 1 0 0 1 1 1 0 Thiamine-binding protein CLTH PF10607.9 EFC47307.1 - 0.11 12.4 0.7 0.34 10.8 0.1 2.2 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain Glycos_transf_4 PF00953.21 EFC47309.1 - 6.7e-39 133.4 11.3 6.7e-39 133.4 11.3 2.0 3 0 0 3 3 3 1 Glycosyl transferase family 4 Peptidase_S8 PF00082.22 EFC47310.1 - 3.9e-30 105.1 0.0 9.3e-30 103.9 0.0 1.6 1 1 0 1 1 1 1 Subtilase family Imm6 PF14434.6 EFC47310.1 - 3.8 7.5 7.4 26 4.8 0.2 3.2 3 0 0 3 3 3 0 Immunity protein Imm6 WD40 PF00400.32 EFC47311.1 - 1.9e-28 98.1 18.8 0.00089 20.0 0.2 11.4 12 0 0 12 12 12 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47311.1 - 6.2e-09 36.1 0.1 3.8 7.9 0.0 7.4 5 2 2 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC47311.1 - 0.021 13.8 0.8 15 4.4 0.0 3.9 4 1 0 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pol_alpha_B_N PF08418.10 EFC47312.1 - 0.03 14.3 0.1 0.038 14.0 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal ZIP4_domain PF18292.1 EFC47312.1 - 0.07 13.1 0.2 0.093 12.6 0.2 1.2 1 0 0 1 1 1 0 Zinc transporter ZIP4 domain PPR PF01535.20 EFC47313.1 - 2.6e-09 36.7 12.1 1.3 9.4 0.1 7.9 8 0 0 8 8 8 4 PPR repeat PPR_2 PF13041.6 EFC47313.1 - 2.7e-08 33.9 13.7 0.0073 16.5 0.2 5.1 6 1 0 6 6 6 3 PPR repeat family PPR_3 PF13812.6 EFC47313.1 - 0.00033 20.7 3.6 0.11 12.6 0.0 4.6 4 1 1 5 5 5 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC47313.1 - 0.036 13.8 3.9 0.43 10.3 0.1 4.0 5 0 0 5 5 5 0 PPR repeat PI3_PI4_kinase PF00454.27 EFC47314.1 - 9.7e-46 156.6 0.0 1.2e-45 156.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EFC47314.1 - 5.8e-14 51.6 0.1 9.3e-14 51.0 0.1 1.3 1 0 0 1 1 1 1 FATC domain Ribosomal_L50 PF10501.9 EFC47316.1 - 6.9e-05 23.0 0.5 6.9e-05 23.0 0.5 3.1 4 0 0 4 4 4 1 Ribosomal subunit 39S DUF3361 PF11841.8 EFC47316.1 - 0.073 13.0 0.8 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) Lyase_aromatic PF00221.19 EFC47317.1 - 6.3e-190 631.8 0.7 7.1e-190 631.6 0.7 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase REJ PF02010.15 EFC47318.1 - 4.4e-39 134.5 9.5 9.4e-38 130.2 5.9 2.8 2 0 0 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC47318.1 - 4.8e-12 46.0 217.2 0.00027 21.2 10.0 14.3 14 1 0 14 14 14 8 EGF-like domain EGF PF00008.27 EFC47318.1 - 0.0015 18.8 4.0 0.0015 18.8 4.0 12.9 14 0 0 14 14 14 7 EGF-like domain Y_Y_Y PF07495.13 EFC47318.1 - 0.044 13.7 0.1 3.7 7.6 0.0 3.6 3 0 0 3 3 3 0 Y_Y_Y domain WD40 PF00400.32 EFC47319.1 - 2.1e-12 47.3 11.3 0.0057 17.5 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47319.1 - 7e-06 26.3 0.0 5.3 7.4 0.0 5.1 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PGI PF00342.19 EFC47320.1 - 1e-48 166.2 1.5 2.6e-43 148.4 1.8 2.0 1 1 0 2 2 2 2 Phosphoglucose isomerase CS PF04969.16 EFC47321.1 - 2.6e-12 47.5 0.4 6.7e-11 43.1 0.0 2.3 2 0 0 2 2 2 1 CS domain Imm42 PF15593.6 EFC47321.1 - 0.04 14.4 1.2 0.049 14.1 1.2 1.1 1 0 0 1 1 1 0 Immunity protein 42 Glyco_hydro2_C5 PF18565.1 EFC47321.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 RAP-1 PF03085.15 EFC47321.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) ANAPC4_WD40 PF12894.7 EFC47322.1 - 0.046 14.0 0.0 3.3 8.1 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TACC_C PF05010.14 EFC47324.1 - 0.096 12.5 13.0 0.85 9.4 0.1 3.7 3 1 0 4 4 4 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal F-box-like PF12937.7 EFC47325.1 - 9.7e-06 25.4 0.2 2.2e-05 24.3 0.2 1.6 1 0 0 1 1 1 1 F-box-like DUF3870 PF12986.7 EFC47326.1 - 0.16 12.2 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3870) Pkinase PF00069.25 EFC47327.1 - 5.8e-07 29.1 0.2 0.013 14.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47327.1 - 1.1e-05 24.8 0.0 0.091 12.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase GARS_N PF02844.15 EFC47327.1 - 0.019 15.7 0.0 0.042 14.6 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain ABC1 PF03109.16 EFC47327.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 ABC1 family Thiolase_N PF00108.23 EFC47328.1 - 4.9e-87 291.6 0.1 6.2e-87 291.2 0.1 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFC47328.1 - 8.6e-43 144.9 0.9 9e-42 141.6 0.4 2.4 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFC47328.1 - 0.0075 15.9 2.9 0.032 13.8 0.7 2.6 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ASC PF00858.24 EFC47329.1 - 6.8e-12 45.1 5.0 2.3e-05 23.6 0.3 3.0 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel ASC PF00858.24 EFC47330.1 - 8.4e-07 28.3 12.4 0.0024 16.9 1.6 3.0 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel TPR_12 PF13424.6 EFC47331.1 - 1.4e-12 47.7 0.3 0.36 11.2 0.0 5.6 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47331.1 - 2e-12 46.2 10.5 0.32 11.2 0.0 8.4 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47331.1 - 1.1e-09 37.7 17.3 0.017 14.9 0.0 8.2 9 1 1 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47331.1 - 2e-08 33.8 15.4 0.97 9.8 0.1 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47331.1 - 6e-08 32.2 6.2 3.3 8.0 0.0 6.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47331.1 - 2.6e-06 27.9 0.2 0.085 13.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC47331.1 - 7.5e-06 26.3 0.6 6.4 7.6 0.0 6.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC47331.1 - 0.00014 21.6 0.1 3 7.8 0.0 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC47331.1 - 0.00056 20.0 0.0 0.11 12.7 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47331.1 - 0.0014 18.3 3.9 26 4.6 0.0 6.2 5 1 1 6 6 6 0 TPR repeat Fis1_TPR_C PF14853.6 EFC47331.1 - 0.0018 18.3 1.7 0.096 12.8 0.4 3.9 3 1 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 EFC47331.1 - 0.0034 18.1 0.0 1e+02 4.2 0.0 5.6 6 1 0 6 6 5 0 Tetratricopeptide repeat TOM20_plant PF06552.12 EFC47331.1 - 0.0087 15.8 2.5 3.3 7.4 0.1 3.3 2 1 1 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_16 PF13432.6 EFC47331.1 - 0.016 15.9 0.0 0.5 11.1 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC47331.1 - 0.048 13.4 2.4 2.7 7.7 0.1 2.9 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_MalT PF17874.1 EFC47331.1 - 0.19 11.0 0.0 0.57 9.5 0.0 1.7 2 0 0 2 2 2 0 MalT-like TPR region SUI1 PF01253.22 EFC47332.1 - 1.7e-23 82.9 1.0 2.4e-23 82.5 1.0 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 TsaE PF02367.17 EFC47333.1 - 5e-13 49.2 0.0 1.1e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFC47333.1 - 4.2e-05 23.5 0.7 0.0027 17.7 0.7 2.5 1 1 0 1 1 1 1 NACHT domain Sigma54_activ_2 PF14532.6 EFC47333.1 - 0.002 18.3 0.2 0.095 12.8 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_7 PF12775.7 EFC47333.1 - 0.0038 16.7 0.1 0.0038 16.7 0.1 2.5 1 1 1 3 3 3 1 P-loop containing dynein motor region AAA_16 PF13191.6 EFC47333.1 - 0.0053 17.2 0.0 0.015 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 EFC47333.1 - 0.0075 16.0 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_33 PF13671.6 EFC47333.1 - 0.0095 16.1 0.8 0.028 14.6 0.8 1.9 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC47333.1 - 0.011 16.1 0.6 0.028 14.7 0.6 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC47333.1 - 0.02 14.6 0.1 0.14 12.0 0.0 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain PI3K_P85_iSH2 PF16454.5 EFC47333.1 - 0.024 14.2 11.9 0.73 9.4 3.6 2.5 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain RNA_helicase PF00910.22 EFC47333.1 - 0.033 14.6 0.1 0.12 12.7 0.1 2.2 1 1 0 1 1 1 0 RNA helicase betaPIX_CC PF16523.5 EFC47333.1 - 0.042 13.7 9.4 0.89 9.4 0.5 2.7 2 0 0 2 2 2 0 betaPIX coiled coil AAA PF00004.29 EFC47333.1 - 0.32 11.4 3.8 0.96 9.9 2.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFC47333.1 - 0.35 11.4 5.8 1.6 9.3 5.8 2.3 1 1 0 1 1 1 0 ABC transporter zf-PARP PF00645.18 EFC47334.1 - 7.5e-10 39.5 0.4 5.1e-09 36.9 0.1 2.5 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF3603 PF12227.8 EFC47334.1 - 0.0051 16.2 0.1 0.017 14.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3603) Cucumopine_C PF18631.1 EFC47334.1 - 0.039 13.9 0.1 0.096 12.6 0.1 1.6 1 0 0 1 1 1 0 Cucumopine synthase C-terminal helical bundle domain Tugs PF17840.1 EFC47334.1 - 0.13 12.5 1.0 0.22 11.8 1.0 1.4 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain SRP54 PF00448.22 EFC47337.1 - 1.9e-66 223.5 0.3 4.1e-66 222.4 0.3 1.6 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 EFC47337.1 - 1.1e-15 58.1 1.5 3.2e-15 56.6 1.5 1.9 1 0 0 1 1 1 1 Signal peptide binding domain CbiA PF01656.23 EFC47337.1 - 5.3e-08 33.0 0.1 2.4e-06 27.6 0.0 2.6 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54_N PF02881.19 EFC47337.1 - 1.3e-07 31.7 1.1 7.4e-07 29.3 0.2 2.6 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain AAA_22 PF13401.6 EFC47337.1 - 6.8e-07 29.6 1.2 2e-06 28.1 0.0 2.3 3 1 1 4 4 3 1 AAA domain ArsA_ATPase PF02374.15 EFC47337.1 - 8.3e-07 28.5 8.6 0.00011 21.5 0.1 3.5 2 2 1 3 3 3 2 Anion-transporting ATPase AAA_31 PF13614.6 EFC47337.1 - 5.6e-05 23.1 0.1 0.00027 20.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFC47337.1 - 6.1e-05 23.1 1.6 0.0015 18.6 0.1 3.0 2 2 1 3 3 3 1 AAA domain ParA PF10609.9 EFC47337.1 - 0.00023 20.7 0.2 0.0024 17.4 0.0 2.6 3 0 0 3 3 3 1 NUBPL iron-transfer P-loop NTPase Zeta_toxin PF06414.12 EFC47337.1 - 0.00056 19.3 0.1 0.0018 17.6 0.0 1.9 2 0 0 2 2 2 1 Zeta toxin AAA_33 PF13671.6 EFC47337.1 - 0.00067 19.8 0.0 0.0016 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC47337.1 - 0.001 18.8 0.0 0.0043 16.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 EFC47337.1 - 0.0031 17.2 0.0 0.0085 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 EFC47337.1 - 0.0031 17.4 0.0 0.0063 16.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 EFC47337.1 - 0.0033 17.8 0.0 0.0098 16.3 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain ATPase PF06745.13 EFC47337.1 - 0.0071 15.7 0.1 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 KaiC DUF2075 PF09848.9 EFC47337.1 - 0.0079 15.5 0.0 0.019 14.2 0.0 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 EFC47337.1 - 0.01 15.0 0.1 0.027 13.6 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein MeaB PF03308.16 EFC47337.1 - 0.019 13.9 0.6 0.055 12.4 0.0 2.0 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 EFC47337.1 - 0.023 14.3 0.0 0.069 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 EFC47337.1 - 0.025 14.6 1.3 0.067 13.2 0.1 2.2 2 2 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_18 PF13238.6 EFC47337.1 - 0.028 14.9 0.3 0.1 13.2 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC47337.1 - 0.03 14.5 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFC47337.1 - 0.033 14.5 0.3 0.19 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFC47337.1 - 0.035 14.0 0.2 0.09 12.7 0.1 1.7 2 0 0 2 2 2 0 Adenylylsulphate kinase cobW PF02492.19 EFC47337.1 - 0.037 13.6 1.9 0.93 9.1 0.9 3.0 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EFC47337.1 - 0.04 13.8 0.1 0.25 11.2 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea SWI2_SNF2 PF18766.1 EFC47337.1 - 0.07 12.8 0.1 0.3 10.7 0.0 2.1 2 0 0 2 2 2 0 SWI2/SNF2 ATPase NTPase_1 PF03266.15 EFC47337.1 - 0.073 13.0 1.0 0.35 10.7 0.1 2.3 2 0 0 2 2 2 0 NTPase AAA_17 PF13207.6 EFC47337.1 - 0.11 13.0 1.1 0.88 10.0 0.2 2.7 2 1 0 2 2 2 0 AAA domain MobB PF03205.14 EFC47337.1 - 0.12 12.3 1.1 5.1 7.0 0.2 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B WD40 PF00400.32 EFC47339.1 - 3.9e-17 62.3 5.2 0.0012 19.6 0.1 6.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47339.1 - 2.3e-14 53.4 0.2 0.0051 17.1 0.0 5.2 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 EFC47339.1 - 0.0061 15.7 1.2 0.024 13.7 0.1 2.0 1 1 1 2 2 2 1 Coatomer WD associated region TSC22 PF01166.18 EFC47339.1 - 0.041 14.2 5.7 0.18 12.1 2.7 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF4930 PF16284.5 EFC47339.1 - 0.046 13.7 0.0 0.19 11.7 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4930) WD40_alt PF14077.6 EFC47339.1 - 0.15 11.9 1.4 0.38 10.6 1.4 1.6 1 0 0 1 1 1 0 Alternative WD40 repeat motif bZIP_1 PF00170.21 EFC47339.1 - 0.3 11.2 6.2 0.35 11.0 2.7 2.5 2 0 0 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 EFC47339.1 - 1.3 9.2 4.8 4 7.6 4.8 1.8 1 0 0 1 1 1 0 Basic region leucine zipper DivIC PF04977.15 EFC47339.1 - 4.5 7.1 7.2 0.65 9.8 2.5 2.0 2 0 0 2 2 2 0 Septum formation initiator Acetyltransf_1 PF00583.25 EFC47340.1 - 2.3e-12 47.2 0.0 2.7e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC47340.1 - 8.5e-09 35.7 0.1 1.1e-08 35.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC47340.1 - 1.2e-06 28.4 0.1 1.7e-06 28.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC47340.1 - 0.00011 22.2 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFC47340.1 - 0.14 12.1 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Kelch_5 PF13854.6 EFC47341.1 - 7.4e-16 57.8 10.5 0.026 14.5 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 EFC47341.1 - 2.3e-14 53.1 9.0 0.0023 17.9 0.0 6.3 5 1 1 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC47341.1 - 1.3e-12 47.6 2.7 0.0053 17.0 0.0 5.4 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC47341.1 - 1.4e-12 47.4 7.3 0.04 14.2 0.1 6.4 6 0 0 6 6 6 3 Kelch motif zf-C3HC4_3 PF13920.6 EFC47341.1 - 5.4e-10 39.0 8.2 5.4e-10 39.0 8.2 2.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Kelch_1 PF01344.25 EFC47341.1 - 3.9e-07 29.5 12.8 0.13 11.9 0.1 5.5 5 0 0 5 5 5 3 Kelch motif Prok-RING_4 PF14447.6 EFC47341.1 - 1.3e-06 28.1 10.0 3.5e-06 26.8 10.0 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFC47341.1 - 3.2e-05 23.7 12.0 3.2e-05 23.7 12.0 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC47341.1 - 0.00035 20.8 11.4 0.00035 20.8 11.4 2.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC47341.1 - 0.00083 19.1 11.9 0.00083 19.1 11.9 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC47341.1 - 0.0027 17.7 9.9 0.0027 17.7 9.9 2.7 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 EFC47341.1 - 0.0031 17.5 9.6 0.0031 17.5 9.6 3.0 2 1 0 2 2 1 1 zinc-RING finger domain Kelch_2 PF07646.15 EFC47341.1 - 0.005 16.8 11.6 0.73 9.9 0.6 5.4 5 0 0 5 5 5 1 Kelch motif zf-C3HC4_4 PF15227.6 EFC47341.1 - 0.015 15.5 10.3 0.015 15.5 10.3 2.7 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING DUF2333 PF10095.9 EFC47341.1 - 0.11 11.5 6.7 0.19 10.7 6.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) zf-RING_11 PF17123.5 EFC47341.1 - 0.41 10.4 8.6 2.2 8.1 8.6 2.4 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_6 PF14835.6 EFC47341.1 - 0.78 9.7 4.8 2.3 8.2 4.8 1.8 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF2935 PF11155.8 EFC47341.1 - 2.8 8.3 13.1 44 4.4 12.9 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) ATG16 PF08614.11 EFC47341.1 - 2.8 8.1 42.6 4.1 7.6 27.8 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) EOS1 PF12326.8 EFC47341.1 - 8 6.4 6.3 20 5.1 6.3 1.6 1 0 0 1 1 1 0 N-glycosylation protein DUF2721 PF11026.8 EFC47342.1 - 0.14 12.1 0.0 0.3 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) RlaP PF10127.9 EFC47343.1 - 6.4e-24 84.9 0.1 1.9e-23 83.3 0.1 1.7 1 1 0 1 1 1 1 RNA repair pathway DNA polymerase beta family SUIM_assoc PF16619.5 EFC47343.1 - 9.7 6.3 8.9 12 6.0 6.9 2.2 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Tubulin PF00091.25 EFC47345.1 - 7.6e-67 225.3 0.0 1e-66 224.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC47345.1 - 1.5e-50 170.6 0.1 2.5e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 EFC47345.1 - 0.0023 17.7 0.0 0.0059 16.3 0.0 1.8 2 0 0 2 2 2 1 Tubulin domain Tubulin_2 PF13809.6 EFC47345.1 - 0.18 10.9 0.1 0.29 10.3 0.1 1.3 1 0 0 1 1 1 0 Tubulin like Med25_VWA PF11265.8 EFC47346.1 - 6.8e-09 35.9 0.2 3.6e-08 33.5 0.2 2.1 1 1 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Pneumo_att_G PF05539.11 EFC47346.1 - 1.9 8.0 28.7 4.4 6.8 28.7 1.5 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Erythro_esteras PF05139.14 EFC47348.1 - 7.6e-101 338.4 0.1 8.9e-101 338.1 0.1 1.0 1 0 0 1 1 1 1 Erythromycin esterase DUF1897 PF09005.10 EFC47348.1 - 0.032 13.7 0.1 0.092 12.3 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1897) dNK PF01712.19 EFC47349.1 - 0.014 15.2 1.9 0.023 14.6 1.9 1.2 1 0 0 1 1 1 0 Deoxynucleoside kinase VASt PF16016.5 EFC47350.1 - 2e-09 38.0 0.1 1e-08 35.7 0.1 2.3 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain SpoIIID PF12116.8 EFC47350.1 - 0.064 13.3 0.6 12 6.0 0.1 2.6 2 0 0 2 2 2 0 Stage III sporulation protein D DUF1764 PF08576.10 EFC47351.1 - 4.6e-18 66.0 6.1 4.6e-18 66.0 6.1 2.1 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) Allexi_40kDa PF05549.11 EFC47351.1 - 1.2 8.6 7.3 1.5 8.3 7.3 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein Borrelia_P83 PF05262.11 EFC47351.1 - 2.2 6.7 30.7 2.7 6.4 30.7 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein SLC12 PF03522.15 EFC47351.1 - 3.3 6.6 21.7 3.9 6.4 21.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Ureide_permease PF07168.11 EFC47351.1 - 3.9 6.1 11.4 5.1 5.7 11.4 1.3 1 0 0 1 1 1 0 Ureide permease Presenilin PF01080.17 EFC47351.1 - 7.2 5.3 16.1 9.1 4.9 16.1 1.1 1 0 0 1 1 1 0 Presenilin Nudix_hydro PF18290.1 EFC47352.1 - 1.5e-17 63.4 0.3 2.8e-17 62.5 0.3 1.5 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 EFC47352.1 - 2.6e-17 63.1 0.0 4.7e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF1657 PF07870.11 EFC47352.1 - 0.98 9.4 3.2 1.8 8.5 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) COG2 PF06148.11 EFC47353.1 - 1.9e-09 37.7 3.3 1.9e-09 37.7 3.3 3.3 4 0 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF5106 PF17127.4 EFC47353.1 - 0.16 12.3 1.9 2.8 8.2 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) Cut12 PF11500.8 EFC47353.1 - 0.82 9.6 3.2 0.64 10.0 0.7 2.1 2 0 0 2 2 2 0 Spindle pole body formation-associated protein HECT PF00632.25 EFC47354.1 - 1.7e-57 195.2 2.4 1.7e-57 195.2 2.4 2.2 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) WWE PF02825.20 EFC47354.1 - 2.2e-08 34.6 0.8 7.1e-08 32.9 0.8 2.0 1 0 0 1 1 1 1 WWE domain Arm PF00514.23 EFC47354.1 - 0.021 14.9 0.0 43 4.3 0.0 4.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Ras PF00071.22 EFC47355.1 - 1.2e-50 171.3 0.1 1.4e-50 171.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47355.1 - 6.4e-23 81.2 0.0 9.4e-23 80.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47355.1 - 1.3e-09 37.8 0.0 1.4e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC47355.1 - 0.00031 20.8 0.0 0.02 15.0 0.0 2.3 1 1 1 2 2 2 1 50S ribosome-binding GTPase Ldh_1_N PF00056.23 EFC47355.1 - 0.052 13.6 0.1 1.7 8.8 0.0 2.5 2 1 1 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain GCP5-Mod21 PF14609.6 EFC47355.1 - 0.079 11.3 0.2 0.096 11.0 0.2 1.0 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 Gtr1_RagA PF04670.12 EFC47355.1 - 0.095 12.0 0.0 0.19 11.1 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Cep57_MT_bd PF06657.13 EFC47356.1 - 0.0038 17.6 1.6 0.012 16.1 1.6 1.8 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 Med9 PF07544.13 EFC47356.1 - 0.0051 16.9 1.8 0.0051 16.9 1.8 2.3 1 1 1 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 CTD_bind PF04818.13 EFC47356.1 - 0.0086 16.9 0.4 0.091 13.6 0.1 2.2 2 0 0 2 2 2 1 RNA polymerase II-binding domain. 7TMR-HDED PF07697.11 EFC47356.1 - 0.024 14.8 2.9 0.035 14.2 2.9 1.2 1 0 0 1 1 1 0 7TM-HD extracellular GLTP PF08718.11 EFC47356.1 - 0.035 14.4 5.7 3.9 7.7 0.3 3.0 1 1 2 3 3 3 0 Glycolipid transfer protein (GLTP) LXG PF04740.12 EFC47356.1 - 0.044 13.5 7.1 0.067 12.9 6.9 1.3 1 1 0 1 1 1 0 LXG domain of WXG superfamily Atypical_Card PF18461.1 EFC47356.1 - 0.052 13.8 0.4 0.13 12.5 0.4 1.6 1 0 0 1 1 1 0 Atypical caspase recruitment domain bVLRF1 PF18826.1 EFC47356.1 - 0.088 12.7 1.1 0.28 11.1 1.1 1.9 1 1 0 1 1 1 0 bacteroidetes VLRF1 release factor ISG65-75 PF11727.8 EFC47356.1 - 0.091 12.0 5.7 0.03 13.6 1.2 1.9 1 1 1 2 2 2 0 Invariant surface glycoprotein HxlR PF01638.17 EFC47356.1 - 0.094 12.6 0.5 0.17 11.8 0.5 1.4 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Macoilin PF09726.9 EFC47356.1 - 0.24 9.9 7.7 0.29 9.6 7.7 1.2 1 0 0 1 1 1 0 Macoilin family SKA1 PF07160.12 EFC47356.1 - 0.29 10.9 7.2 0.46 10.3 7.2 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF1664 PF07889.12 EFC47356.1 - 0.62 10.1 4.9 1.2 9.2 3.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1043 PF06295.12 EFC47356.1 - 1.6 8.7 6.2 14 5.7 6.2 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) DUF4200 PF13863.6 EFC47356.1 - 1.7 9.1 8.8 0.12 12.8 2.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Fib_alpha PF08702.10 EFC47356.1 - 4 7.6 11.7 2 8.6 1.1 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PRKG1_interact PF15898.5 EFC47356.1 - 4.1 8.3 9.3 1.9 9.4 6.5 1.9 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain TMPIT PF07851.13 EFC47356.1 - 4.4 6.5 7.4 2.9 7.1 5.7 1.5 1 1 0 1 1 1 0 TMPIT-like protein ORC6 PF05460.13 EFC47356.1 - 7 5.8 14.9 14 4.8 14.9 1.6 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2407_C PF13373.6 EFC47356.1 - 7.2 6.8 8.6 9.6 6.4 6.9 2.2 2 1 0 2 2 2 0 DUF2407 C-terminal domain ECH_2 PF16113.5 EFC47358.1 - 1.3e-96 324.1 0.0 1.6e-96 323.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 EFC47358.1 - 1e-31 110.2 0.0 2.1e-30 105.9 0.0 2.0 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase DUF502 PF04367.13 EFC47359.1 - 0.079 12.9 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF502) ubiquitin PF00240.23 EFC47360.1 - 1.2e-06 28.1 0.0 2.3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 EFC47360.1 - 0.0018 18.8 0.0 0.0041 17.6 0.0 1.6 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EFC47360.1 - 0.0072 16.1 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like GCOM2 PF15328.6 EFC47360.1 - 0.11 12.9 0.5 0.16 12.4 0.5 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 TMCO5 PF14992.6 EFC47361.1 - 0.0013 18.4 1.9 0.0016 18.1 1.9 1.1 1 0 0 1 1 1 1 TMCO5 family CENP-Q PF13094.6 EFC47361.1 - 0.0027 18.0 0.2 0.0034 17.6 0.2 1.4 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF16 PF01519.16 EFC47361.1 - 0.024 15.1 3.3 0.038 14.5 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 DDE_Tnp_1_2 PF13586.6 EFC47361.1 - 0.12 12.8 0.0 0.2 12.0 0.0 1.4 1 0 0 1 1 1 0 Transposase DDE domain Sec1 PF00995.23 EFC47362.1 - 9.6e-19 68.0 25.7 9.6e-19 68.0 25.7 2.5 1 1 1 2 2 2 1 Sec1 family VWA PF00092.28 EFC47362.1 - 0.13 12.5 2.3 0.53 10.5 0.2 3.1 3 1 0 3 3 3 0 von Willebrand factor type A domain Fer2 PF00111.27 EFC47363.1 - 5.8e-12 45.4 0.0 7.5e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain ADIP PF11559.8 EFC47364.1 - 0.015 15.3 4.1 0.015 15.3 4.1 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding GvpK PF05121.12 EFC47364.1 - 0.088 12.9 3.4 1.3 9.1 0.1 2.7 2 0 0 2 2 2 0 Gas vesicle protein K Peptidase_S28 PF05577.12 EFC47364.1 - 0.41 9.4 0.0 0.41 9.4 0.0 1.8 2 0 0 2 2 2 0 Serine carboxypeptidase S28 DUF4094 PF13334.6 EFC47364.1 - 1.2 9.6 6.0 0.26 11.7 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) TTL PF03133.15 EFC47365.1 - 2e-58 197.9 5.0 2.3e-58 197.7 0.7 2.0 1 1 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFC47365.1 - 4.2e-07 29.5 0.4 0.0014 18.0 0.0 3.1 2 1 0 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFC47365.1 - 0.086 12.1 0.0 0.25 10.6 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Lep_receptor_Ig PF06328.11 EFC47365.1 - 0.11 12.5 0.2 0.29 11.1 0.2 1.7 1 0 0 1 1 1 0 Ig-like C2-type domain TK PF00265.18 EFC47365.1 - 0.29 11.0 1.6 7.1 6.5 0.2 2.4 2 0 0 2 2 2 0 Thymidine kinase QueH PF02677.14 EFC47365.1 - 0.48 10.5 4.1 0.37 10.9 1.5 2.0 2 1 0 2 2 2 0 Epoxyqueuosine reductase QueH HSCB_C PF07743.13 EFC47366.1 - 2.2e-14 53.7 6.7 2.6e-14 53.4 1.5 2.2 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 EFC47366.1 - 4.9e-05 23.4 0.4 0.00015 21.8 0.4 1.8 1 0 0 1 1 1 1 DnaJ domain zinc_ribbon_2 PF13240.6 EFC47366.1 - 0.13 12.1 6.7 0.36 10.6 6.7 1.8 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EFC47366.1 - 2.2 8.4 12.6 0.54 10.3 8.6 2.0 2 0 0 2 2 2 0 Double zinc ribbon HscB_4_cys PF18256.1 EFC47366.1 - 6.3 6.7 8.4 20 5.1 8.4 1.9 1 1 0 1 1 1 0 Co-chaperone HscB tetracysteine metal binding motif DUF3730 PF12530.8 EFC47367.1 - 1.8e-23 83.3 5.8 2.4e-23 82.9 2.0 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF3730) HEAT PF02985.22 EFC47367.1 - 0.02 15.1 0.1 0.47 10.8 0.0 3.6 2 0 0 2 2 2 0 HEAT repeat Ribosomal_S16 PF00886.19 EFC47368.1 - 6e-22 77.5 0.0 1.3e-21 76.4 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein S16 COQ9 PF08511.11 EFC47369.1 - 2.6e-23 81.6 0.0 6e-23 80.4 0.0 1.7 1 0 0 1 1 1 1 COQ9 RasGEF PF00617.19 EFC47370.1 - 5.5e-48 163.5 0.1 1.2e-47 162.5 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain PH PF00169.29 EFC47370.1 - 1.6e-06 28.5 0.0 6.5e-06 26.6 0.0 2.1 1 0 0 1 1 1 1 PH domain RasGEF_N PF00618.20 EFC47370.1 - 1.2e-05 25.5 2.4 2.2e-05 24.6 0.7 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif REJ PF02010.15 EFC47371.1 - 1.7e-45 155.7 14.1 5e-44 150.8 8.0 3.1 2 1 1 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC47371.1 - 2.8e-05 24.4 253.5 0.00044 20.6 7.3 17.6 17 1 0 17 17 17 10 EGF-like domain IPPT PF01715.17 EFC47372.1 - 5.7e-53 180.1 0.7 5.7e-53 180.1 0.7 2.0 2 0 0 2 2 2 1 IPP transferase IPT PF01745.16 EFC47372.1 - 0.0012 18.3 0.0 0.0032 16.9 0.0 1.8 1 0 0 1 1 1 1 Isopentenyl transferase RNA_helicase PF00910.22 EFC47372.1 - 0.0061 16.9 0.9 0.14 12.5 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EFC47372.1 - 0.008 16.7 4.0 1.4 9.5 0.2 3.0 3 0 0 3 3 3 2 AAA domain AAA_26 PF13500.6 EFC47372.1 - 0.011 15.6 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFC47372.1 - 0.016 14.5 0.0 0.034 13.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin T2SSE PF00437.20 EFC47372.1 - 0.021 13.9 0.0 0.53 9.3 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein TIP49 PF06068.13 EFC47372.1 - 0.025 13.8 0.1 0.048 12.9 0.1 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_16 PF13191.6 EFC47372.1 - 0.046 14.1 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 EFC47372.1 - 0.057 13.5 0.2 0.17 11.9 0.2 1.8 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 EFC47372.1 - 0.072 13.4 1.2 0.69 10.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain IstB_IS21 PF01695.17 EFC47372.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 EFC47372.1 - 0.1 12.5 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Ribosomal_L10 PF00466.20 EFC47373.1 - 6.1e-20 71.2 2.4 6.1e-20 71.2 2.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 EFC47373.1 - 1.3e-17 63.6 0.0 2.1e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P DIM1 PF02966.16 EFC47373.1 - 0.0033 17.2 0.5 0.0069 16.2 0.2 1.7 2 0 0 2 2 2 1 Mitosis protein DIM1 Syntaxin_2 PF14523.6 EFC47373.1 - 0.0075 16.6 1.6 1.6 9.2 0.7 2.6 2 1 0 2 2 2 2 Syntaxin-like protein SpvD PF05563.12 EFC47373.1 - 0.036 13.7 0.0 0.08 12.6 0.0 1.5 1 1 0 1 1 1 0 Salmonella plasmid virulence protein SpvD CLN3 PF02487.17 EFC47374.1 - 5.4e-119 397.8 34.1 8.2e-61 206.2 4.6 2.4 2 1 1 3 3 3 2 CLN3 protein AvrL567-A PF11529.8 EFC47375.1 - 0.029 14.5 0.0 0.059 13.6 0.0 1.5 1 0 0 1 1 1 0 Melampsora lini avirulence protein AvrL567-A Abhydrolase_6 PF12697.7 EFC47376.1 - 1.3e-05 25.9 0.0 1.6e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC47376.1 - 0.00091 18.9 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2048 PF09752.9 EFC47376.1 - 0.0048 16.1 0.0 0.0057 15.8 0.0 1.1 1 0 0 1 1 1 1 Abhydrolase domain containing 18 ELMO_CED12 PF04727.13 EFC47377.1 - 1.4e-37 129.5 1.9 1.4e-37 129.5 1.9 1.7 2 0 0 2 2 2 1 ELMO/CED-12 family FAS_N PF17828.1 EFC47377.1 - 0.018 15.0 3.1 0.48 10.4 1.2 2.3 2 0 0 2 2 2 0 N-terminal domain in fatty acid synthase subunit beta RhoGAP PF00620.27 EFC47378.1 - 2.4e-38 131.3 2.4 3.4e-38 130.9 0.1 2.3 3 0 0 3 3 3 1 RhoGAP domain BAR_3 PF16746.5 EFC47378.1 - 0.0011 18.7 5.4 0.0011 18.7 5.4 1.7 2 0 0 2 2 2 1 BAR domain of APPL family Cnd3 PF12719.7 EFC47378.1 - 0.026 13.7 2.0 0.068 12.4 2.0 1.7 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain CPDase PF07823.11 EFC47378.1 - 0.048 13.4 0.3 0.095 12.4 0.3 1.4 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein DUF2115 PF09888.9 EFC47378.1 - 1.4 9.4 8.1 0.97 9.9 4.8 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Glyco_transf_8 PF01501.20 EFC47379.1 - 2.4e-08 33.9 10.8 3.9e-06 26.6 10.8 2.5 1 1 0 1 1 1 1 Glycosyl transferase family 8 Pilin_N PF07790.11 EFC47379.1 - 0.15 13.0 0.3 0.15 13.0 0.3 2.7 3 0 0 3 3 3 0 Archaeal Type IV pilin, N-terminal COX4 PF02936.14 EFC47379.1 - 0.21 11.6 3.2 0.3 11.1 0.1 2.8 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IV DUF4834 PF16118.5 EFC47379.1 - 2.3 9.2 0.0 2.3 9.2 0.0 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) DUF2207 PF09972.9 EFC47379.1 - 3.3 6.4 14.5 6.4 5.4 0.0 3.2 2 1 1 3 3 3 0 Predicted membrane protein (DUF2207) CD34_antigen PF06365.12 EFC47379.1 - 4.4 6.8 5.0 0.62 9.6 0.1 2.0 2 0 0 2 2 2 0 CD34/Podocalyxin family RhoGEF PF00621.20 EFC47381.1 - 5.8e-40 137.5 1.9 5.8e-40 137.5 1.9 2.1 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 EFC47381.1 - 0.1 13.1 0.1 0.43 11.1 0.1 2.2 1 0 0 1 1 1 0 PH domain OPT PF03169.15 EFC47382.1 - 1.3e-119 400.6 41.7 1.5e-119 400.4 41.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.16 EFC47383.1 - 3.7e-20 72.2 33.7 3.7e-20 72.2 33.7 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 EFC47383.1 - 2.3e-08 33.0 20.0 2.3e-08 33.0 20.0 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein DUF4131 PF13567.6 EFC47383.1 - 0.45 10.2 15.0 6.7 6.3 0.0 4.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) UQ_con PF00179.26 EFC47384.1 - 8.5e-44 148.6 0.0 9.6e-44 148.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC47384.1 - 1.8e-05 24.4 0.0 2.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFC47384.1 - 0.03 14.2 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 EFC47384.1 - 0.059 13.7 0.0 0.067 13.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain TBCC PF07986.12 EFC47385.1 - 5.5e-39 132.6 4.8 8.7e-39 132.0 4.8 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C CAP_C PF08603.11 EFC47385.1 - 0.00026 20.7 0.3 0.0005 19.7 0.3 1.4 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal DUF4469 PF14734.6 EFC47385.1 - 0.11 12.6 0.5 0.38 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4469) with IG-like fold HATPase_c_3 PF13589.6 EFC47386.1 - 5.8e-13 48.9 0.0 3.7e-12 46.2 0.0 2.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SMC_hinge PF06470.13 EFC47386.1 - 3.4e-09 37.0 0.0 2e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain HATPase_c PF02518.26 EFC47386.1 - 0.00013 22.4 0.1 0.00096 19.6 0.0 2.6 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S3Ae PF01015.18 EFC47387.1 - 1.1e-31 110.0 9.6 1.7e-31 109.4 9.6 1.3 1 0 0 1 1 1 1 Ribosomal S3Ae family Nrap_D2 PF17403.2 EFC47387.1 - 0.071 12.9 0.5 0.12 12.1 0.5 1.3 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Herpes_BLRF2 PF05812.12 EFC47387.1 - 1.4 9.1 7.7 18 5.5 3.6 3.1 2 1 0 2 2 2 0 Herpesvirus BLRF2 protein Piwi PF02171.17 EFC47389.1 - 5.8e-34 117.7 1.0 5.8e-34 117.7 1.0 1.5 2 0 0 2 2 2 1 Piwi domain PAZ PF02170.22 EFC47389.1 - 3.5e-21 75.5 7.4 6.3e-21 74.6 6.8 1.7 2 0 0 2 2 2 1 PAZ domain GRP PF07172.11 EFC47389.1 - 8 7.2 30.0 15 6.3 30.0 1.4 1 0 0 1 1 1 0 Glycine rich protein family Actin PF00022.19 EFC47390.1 - 2.1e-88 296.7 0.0 8.5e-87 291.4 0.0 2.0 1 1 0 1 1 1 1 Actin DUF4064 PF13273.6 EFC47390.1 - 0.077 13.3 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) MreB_Mbl PF06723.13 EFC47390.1 - 0.15 10.8 0.0 12 4.6 0.0 2.7 3 0 0 3 3 3 0 MreB/Mbl protein Chromate_transp PF02417.15 EFC47391.1 - 5.2e-63 211.9 39.2 1.6e-37 129.1 14.9 2.5 2 1 1 3 3 3 2 Chromate transporter Pex24p PF06398.11 EFC47391.1 - 0.001 18.1 4.6 0.0039 16.2 4.6 2.0 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin Phage_holin_3_1 PF05106.12 EFC47391.1 - 0.44 11.0 7.4 0.33 11.4 0.6 2.6 2 0 0 2 2 2 0 Phage holin family (Lysis protein S) DUF3952 PF13130.6 EFC47391.1 - 0.51 10.5 4.2 1.3 9.2 4.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3952) GSHPx PF00255.19 EFC47392.1 - 2.4e-40 136.5 0.7 3.2e-40 136.1 0.7 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EFC47392.1 - 4.1e-10 39.6 0.1 6.5e-10 39.0 0.1 1.5 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC47392.1 - 1.1e-07 31.6 0.1 2.8e-07 30.4 0.1 1.8 1 1 0 1 1 1 1 Redoxin NmrA PF05368.13 EFC47393.1 - 2.3e-17 63.4 0.0 2.8e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC47393.1 - 4.6e-09 36.4 0.0 8e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 EFC47393.1 - 0.0012 18.4 0.0 0.018 14.5 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 EFC47393.1 - 0.0035 17.7 0.0 0.0081 16.6 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 EFC47393.1 - 0.014 15.5 0.1 0.062 13.4 0.0 2.0 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Gemini_V2 PF01524.17 EFC47393.1 - 0.019 15.1 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 Geminivirus V2 protein DXP_reductoisom PF02670.16 EFC47393.1 - 0.096 13.4 0.1 0.29 11.8 0.0 1.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase TrkA_N PF02254.18 EFC47393.1 - 0.099 12.9 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain RmlD_sub_bind PF04321.17 EFC47393.1 - 0.15 11.1 0.1 1.4 7.9 0.0 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain SRP14 PF02290.15 EFC47393.1 - 0.17 12.3 0.4 0.7 10.3 0.0 2.1 2 0 0 2 2 2 0 Signal recognition particle 14kD protein TEX19 PF15553.6 EFC47394.1 - 0.19 11.7 0.3 0.43 10.5 0.3 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 Mito_carr PF00153.27 EFC47397.1 - 3.3e-71 235.3 4.4 4e-24 84.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RAP1 PF07218.11 EFC47397.1 - 0.043 12.1 0.3 0.059 11.7 0.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RGS PF00615.19 EFC47398.1 - 3e-05 24.3 0.4 7.1e-05 23.1 0.4 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF2478 PF10649.9 EFC47399.1 - 0.068 12.8 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2478) NUDIX PF00293.28 EFC47400.1 - 1.5e-12 47.7 0.0 1.9e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Ank_2 PF12796.7 EFC47402.1 - 4.3e-18 65.7 0.3 0.0034 17.9 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47402.1 - 3.6e-10 39.2 1.4 0.85 10.4 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 EFC47402.1 - 1.7e-09 38.0 0.4 0.0038 17.8 0.0 5.3 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC47402.1 - 1e-08 35.3 0.0 0.35 11.3 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeats (many copies) AF2331-like PF14556.6 EFC47402.1 - 4.1 8.0 4.9 3.3 8.3 0.7 2.8 3 0 0 3 3 3 0 AF2331-like Metallophos PF00149.28 EFC47403.1 - 9.1e-07 29.6 0.0 1.9e-06 28.5 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Kinesin PF00225.23 EFC47404.1 - 1.7e-104 349.4 4.8 2.2e-104 349.0 4.8 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC47404.1 - 4.6e-29 101.3 1.3 8.2e-29 100.5 1.3 1.4 1 0 0 1 1 1 1 Microtubule binding Pox_A_type_inc PF04508.12 EFC47404.1 - 0.023 14.5 1.4 0.072 13.0 1.4 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Mac-1 PF09028.10 EFC47405.1 - 0.078 12.0 1.0 0.17 10.9 1.0 1.4 1 0 0 1 1 1 0 Mac 1 Ins_allergen_rp PF06757.13 EFC47405.1 - 0.6 10.0 5.1 2.7 7.9 0.0 3.6 4 1 0 4 4 4 0 Insect allergen related repeat, nitrile-specifier detoxification NHL PF01436.21 EFC47406.1 - 7.9e-10 38.3 6.9 3.1e-05 23.8 0.0 4.7 5 0 0 5 5 5 2 NHL repeat GPS PF01825.21 EFC47406.1 - 1.9e-05 25.1 0.3 4.9e-05 23.8 0.3 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC47406.1 - 0.015 15.7 7.2 0.039 14.3 7.2 1.8 1 0 0 1 1 1 0 EGF-like domain HepII_C PF18675.1 EFC47406.1 - 0.022 14.9 0.1 0.078 13.1 0.1 2.0 1 0 0 1 1 1 0 Heparinase II C-terminal domain EGF PF00008.27 EFC47406.1 - 0.047 14.0 4.0 0.18 12.1 4.0 2.0 1 0 0 1 1 1 0 EGF-like domain Arylesterase PF01731.20 EFC47406.1 - 0.093 12.9 2.3 0.87 9.8 0.0 3.6 4 0 0 4 4 4 0 Arylesterase DUF1206 PF06724.11 EFC47406.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) Syndecan PF01034.20 EFC47406.1 - 8.6 6.4 8.5 54 3.8 8.5 2.4 1 1 0 1 1 1 0 Syndecan domain PB1 PF00564.24 EFC47408.1 - 4.1e-06 26.6 0.3 9.3e-06 25.5 0.3 1.5 1 0 0 1 1 1 1 PB1 domain zf-RVT PF13966.6 EFC47408.1 - 0.019 15.7 1.5 0.069 13.9 1.5 2.0 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase DUF1015 PF06245.11 EFC47408.1 - 0.023 13.5 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) RSN1_7TM PF02714.15 EFC47409.1 - 7.9e-08 31.9 8.2 7.9e-08 31.9 8.2 1.5 1 1 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate DUF2418 PF10332.9 EFC47409.1 - 0.41 11.2 5.4 0.16 12.5 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2418) DUF3311 PF11755.8 EFC47409.1 - 7.7 6.5 7.1 0.38 10.7 1.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) NHL PF01436.21 EFC47410.1 - 4.1e-78 253.7 0.0 1.1e-06 28.4 0.0 10.3 10 0 0 10 10 10 10 NHL repeat SGL PF08450.12 EFC47410.1 - 1.7e-12 47.4 7.8 0.00031 20.4 0.1 5.7 1 1 3 6 6 6 5 SMP-30/Gluconolactonase/LRE-like region Linker_histone PF00538.19 EFC47410.1 - 4.6e-10 39.7 1.5 6 7.3 0.0 8.7 8 1 1 9 9 9 1 linker histone H1 and H5 family Arylesterase PF01731.20 EFC47410.1 - 4.3e-07 30.0 33.1 0.17 12.1 0.1 9.3 10 0 0 10 10 10 3 Arylesterase DUF4537 PF15057.6 EFC47410.1 - 0.00012 22.1 0.6 2.7 8.0 0.0 4.4 3 2 0 3 3 3 2 Domain of unknown function (DUF4537) ChitinaseA_N PF08329.10 EFC47410.1 - 0.0044 16.7 8.7 5.6 6.6 0.0 6.9 2 2 6 9 9 9 1 Chitinase A, N-terminal domain LUD_dom PF02589.15 EFC47410.1 - 0.13 11.9 8.1 6.3 6.5 0.1 5.1 6 1 0 6 6 6 0 LUD domain Phytase-like PF13449.6 EFC47410.1 - 0.18 11.7 2.6 89 2.9 0.2 5.1 3 2 1 4 4 4 0 Esterase-like activity of phytase MinC_C PF03775.16 EFC47410.1 - 0.9 9.6 10.7 22 5.1 0.0 5.7 2 2 5 7 7 7 0 Septum formation inhibitor MinC, C-terminal domain EGF_2 PF07974.13 EFC47410.1 - 1.1 9.7 9.1 0.097 13.1 3.6 2.2 2 0 0 2 2 1 0 EGF-like domain rve_2 PF13333.6 EFC47410.1 - 1.7 8.9 15.6 10 6.4 0.1 6.2 8 0 0 8 8 7 0 Integrase core domain Pkinase PF00069.25 EFC47411.1 - 4.1e-44 150.9 0.9 8.8e-44 149.8 0.9 1.5 1 0 0 1 1 1 1 Protein kinase domain EGF_2 PF07974.13 EFC47411.1 - 6e-34 116.1 167.8 9.7e-05 22.7 8.1 10.7 10 0 0 10 10 10 10 EGF-like domain Pkinase_Tyr PF07714.17 EFC47411.1 - 4.1e-27 95.1 0.1 7.8e-27 94.2 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC47411.1 - 2.2e-18 65.2 0.0 8.3e-06 25.6 0.0 4.2 4 0 0 4 4 4 3 NHL repeat Pkinase_fungal PF17667.1 EFC47411.1 - 0.0017 17.2 0.0 0.003 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase rve_2 PF13333.6 EFC47411.1 - 0.9 9.8 3.6 29 4.9 0.1 4.0 4 0 0 4 4 4 0 Integrase core domain MORN PF02493.20 EFC47413.1 - 2.6e-14 52.2 32.4 0.00026 20.7 0.1 6.0 6 0 0 6 6 6 5 MORN repeat DUF1134 PF06577.12 EFC47413.1 - 0.26 11.0 5.3 2.1 8.1 1.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1134) Lysine_decarbox PF03641.14 EFC47415.1 - 4.4e-37 127.1 0.0 5.9e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFC47415.1 - 2.7e-14 53.0 0.1 3.2e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 SLOG cluster4 family Pkinase PF00069.25 EFC47416.1 - 2.4e-30 105.8 0.4 2.4e-30 105.8 0.4 2.1 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47416.1 - 1e-23 84.0 0.1 1.8e-23 83.1 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_2 PF12796.7 EFC47416.1 - 1.5e-06 28.7 0.4 1.2e-05 25.9 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47416.1 - 0.00039 20.6 0.0 0.48 11.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Pkinase_fungal PF17667.1 EFC47416.1 - 0.0009 18.1 0.0 0.002 17.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Ank_5 PF13857.6 EFC47416.1 - 0.0031 17.8 0.0 0.0097 16.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RPN1_RPN2_N PF17781.1 EFC47417.1 - 2e-112 375.6 3.4 3.4e-112 374.9 3.4 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 EFC47417.1 - 4.8e-27 93.8 0.0 1e-26 92.7 0.0 1.6 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 EFC47417.1 - 2.4e-22 78.1 9.9 5.6e-05 23.4 0.0 8.3 8 0 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFC47417.1 - 4.1e-05 23.9 0.0 0.34 11.3 0.0 3.9 3 1 1 4 4 4 2 HEAT repeats Apolipoprotein PF01442.18 EFC47417.1 - 0.28 11.1 3.1 3.6 7.4 0.3 2.8 3 0 0 3 3 3 0 Apolipoprotein A1/A4/E domain SARAF PF06682.12 EFC47418.1 - 0.00083 19.1 0.9 0.001 18.8 0.9 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Glug PF07581.12 EFC47418.1 - 0.24 11.9 0.6 0.38 11.3 0.6 1.4 1 0 0 1 1 1 0 The GLUG motif EGF_2 PF07974.13 EFC47419.1 - 3e-21 75.5 154.7 0.00047 20.5 13.1 9.7 9 0 0 9 9 9 9 EGF-like domain RGS PF00615.19 EFC47419.1 - 6e-08 33.0 5.4 6e-07 29.8 4.8 2.9 3 0 0 3 3 3 1 Regulator of G protein signaling domain Arylesterase PF01731.20 EFC47419.1 - 0.0024 18.1 5.4 0.01 16.1 0.2 3.2 3 0 0 3 3 3 1 Arylesterase EGF_Tenascin PF18720.1 EFC47419.1 - 0.0025 17.8 7.1 0.0025 17.8 7.1 9.0 9 0 0 9 9 9 2 Tenascin EGF domain PuR_N PF09182.10 EFC47419.1 - 0.091 12.7 0.0 0.28 11.1 0.0 1.8 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal He_PIG PF05345.12 EFC47419.1 - 0.8 9.9 3.0 0.52 10.5 0.4 2.1 2 0 0 2 2 2 0 Putative Ig domain Frag1 PF10277.9 EFC47420.1 - 4.6e-14 52.5 7.6 8e-14 51.7 7.6 1.4 1 1 0 1 1 1 1 Frag1/DRAM/Sfk1 family PhoR PF11808.8 EFC47420.1 - 0.051 14.0 1.2 5.8 7.4 0.9 2.6 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR Vpu PF00558.19 EFC47420.1 - 0.11 12.2 0.5 1 9.2 0.3 2.5 2 0 0 2 2 2 0 Vpu protein Flagellin_C PF00700.21 EFC47420.1 - 0.29 11.5 3.3 1.3 9.4 0.1 2.9 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region Guanylate_cyc PF00211.20 EFC47421.1 - 9.4e-19 67.7 2.2 5.2e-11 42.5 0.2 2.5 1 1 1 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC47421.1 - 7.9e-12 45.4 0.0 2.7e-11 43.6 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC47421.1 - 1.9e-06 27.9 0.0 4.8e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC47421.1 - 0.00099 19.3 0.0 0.0031 17.8 0.0 1.9 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC47421.1 - 0.041 13.3 1.5 0.065 12.7 0.2 2.0 2 0 0 2 2 2 0 Heme NO binding associated 30K_MP_C_Ter PF11330.8 EFC47421.1 - 0.57 9.5 3.3 8.1 5.7 1.6 2.7 2 0 0 2 2 2 0 C-Terminal of 30K viral movement proteins DUF2976 PF11190.8 EFC47421.1 - 0.78 9.6 6.3 1.4 8.7 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) Cellulase PF00150.18 EFC47422.1 - 2.5e-07 30.4 0.0 4.4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 EFC47422.1 - 0.0029 17.0 0.1 0.018 14.4 0.0 1.9 2 0 0 2 2 2 1 Beta-galactosidase Endotoxin_C PF03944.14 EFC47422.1 - 0.01 16.2 0.5 0.077 13.3 0.1 2.4 2 0 0 2 2 2 0 delta endotoxin Glyco_hydro_14 PF01373.17 EFC47422.1 - 0.017 14.1 0.2 0.036 13.0 0.1 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 14 Actin PF00022.19 EFC47423.1 - 9.7e-17 60.7 0.0 1.8e-12 46.6 0.0 2.4 2 0 0 2 2 2 2 Actin 2OG-FeII_Oxy_3 PF13640.6 EFC47423.1 - 5.9e-08 33.5 0.2 4e-07 30.8 0.1 2.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily START PF01852.19 EFC47423.1 - 4.1e-06 26.3 0.0 0.00021 20.8 0.0 2.6 2 0 0 2 2 2 1 START domain F-box-like PF12937.7 EFC47423.1 - 5.5e-05 23.0 0.0 0.00018 21.3 0.0 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC47423.1 - 0.022 14.6 0.0 0.087 12.7 0.0 2.1 1 0 0 1 1 1 0 F-box domain 2OG-FeII_Oxy_3 PF13640.6 EFC47424.1 - 1.6e-10 41.7 0.3 8.9e-10 39.3 0.3 2.3 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Tnp_zf-ribbon_2 PF13842.6 EFC47424.1 - 0.026 15.3 6.2 0.026 15.3 6.2 2.7 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Glyco_transf_36 PF06165.11 EFC47424.1 - 0.038 13.4 1.2 0.6 9.5 0.1 2.8 3 0 0 3 3 3 0 Glycosyltransferase family 36 zf-AN1 PF01428.16 EFC47424.1 - 0.81 9.9 20.6 0.65 10.2 7.5 2.8 2 0 0 2 2 2 0 AN1-like Zinc finger FYVE PF01363.21 EFC47424.1 - 1.2 9.3 19.2 2.3 8.4 5.5 2.7 1 1 1 2 2 2 0 FYVE zinc finger DUF4637 PF15470.6 EFC47424.1 - 4.9 6.8 11.5 4.1 7.1 1.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4637) Pkinase PF00069.25 EFC47425.1 - 1.3e-21 77.1 0.2 6.8e-20 71.5 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47425.1 - 8.5e-21 74.4 0.1 2.6e-18 66.3 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC47425.1 - 0.0036 16.7 0.0 0.0041 16.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFC47425.1 - 0.0058 15.6 0.0 0.0072 15.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC47425.1 - 0.006 16.5 0.0 0.007 16.3 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC47425.1 - 0.1 11.4 0.1 0.11 11.2 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase NHL PF01436.21 EFC47427.1 - 5.3e-43 142.9 15.8 1.8e-05 24.5 0.0 7.9 7 0 0 7 7 7 7 NHL repeat BTB PF00651.31 EFC47427.1 - 9.9e-09 35.4 0.4 9.9e-09 35.4 0.4 2.7 4 0 0 4 4 3 1 BTB/POZ domain SGL PF08450.12 EFC47427.1 - 5.4e-07 29.4 0.0 17 4.9 0.0 6.1 4 3 2 7 7 7 0 SMP-30/Gluconolactonase/LRE-like region Linker_histone PF00538.19 EFC47427.1 - 1.9e-06 28.1 11.5 20 5.6 0.0 7.9 8 0 0 8 8 8 0 linker histone H1 and H5 family TRL PF13146.6 EFC47427.1 - 0.00033 20.8 9.5 12 6.2 0.1 6.5 7 0 0 7 7 7 1 TRL-like protein family MJ1316 PF04457.12 EFC47427.1 - 0.003 18.3 6.2 2.2e+02 2.7 0.0 6.5 6 0 0 6 6 6 0 MJ1316 RNA cyclic group end recognition domain Phytase-like PF13449.6 EFC47427.1 - 0.015 15.3 0.1 61 3.4 0.0 4.4 3 1 0 3 3 3 0 Esterase-like activity of phytase YtzH PF14165.6 EFC47427.1 - 0.018 15.4 4.2 4.2 7.8 0.3 2.7 2 0 0 2 2 2 0 YtzH-like protein DUF1236 PF06823.12 EFC47427.1 - 0.027 14.4 16.9 7.5 6.5 0.1 6.2 7 0 0 7 7 7 0 Protein of unknown function (DUF1236) MSP7_C PF12948.7 EFC47427.1 - 0.19 12.4 13.4 0.84 10.3 0.4 3.7 3 0 0 3 3 3 0 MSP7-like protein C-terminal domain HrcA_DNA-bdg PF03444.15 EFC47427.1 - 0.6 9.8 2.5 27 4.5 0.2 2.7 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF5125 PF17163.4 EFC47427.1 - 1.8 8.7 10.2 91 3.2 0.1 5.0 7 0 0 7 7 5 0 Domain of unknown function (DUF5125) Plasmo_rep PF12135.8 EFC47427.1 - 3.8 7.1 40.7 15 5.3 0.1 7.9 7 0 0 7 7 7 0 Plasmodium repeat family Glyco_hydro_59M PF17387.2 EFC47429.1 - 0.035 14.2 2.6 0.2 11.8 0.6 2.4 1 1 1 2 2 2 0 Glycosyl hydrolase family 59 central domain DnaB_2 PF07261.11 EFC47430.1 - 0.016 14.9 2.2 0.062 13.0 1.2 2.4 1 1 1 2 2 2 0 Replication initiation and membrane attachment GatB_Yqey PF02637.18 EFC47430.1 - 0.05 13.5 0.8 13 5.7 0.0 2.8 2 1 0 2 2 2 0 GatB domain Cullin PF00888.22 EFC47431.1 - 2.2e-184 614.5 29.0 3e-184 614.1 29.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 EFC47431.1 - 1.8e-27 95.2 2.4 1.8e-27 95.2 2.4 2.7 2 0 0 2 2 2 1 Cullin protein neddylation domain Na_Ca_ex_C PF16494.5 EFC47431.1 - 0.024 15.1 7.2 0.031 14.8 3.9 2.8 2 1 0 2 2 2 0 C-terminal extension of sodium/calcium exchanger domain EF-hand_3 PF09069.11 EFC47431.1 - 0.28 11.6 1.7 1.2 9.6 0.2 2.8 3 0 0 3 3 3 0 EF-hand Gal_mutarotas_2 PF13802.6 EFC47432.1 - 2.3 8.6 6.4 0.72 10.2 2.8 2.0 2 0 0 2 2 2 0 Galactose mutarotase-like YabA PF06156.13 EFC47433.1 - 0.0017 18.9 5.2 0.0017 18.9 5.2 2.7 1 1 2 3 3 3 1 Initiation control protein YabA CENP-F_leu_zip PF10473.9 EFC47433.1 - 0.0019 18.2 22.5 0.0092 16.0 8.3 2.4 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Shugoshin_N PF07558.11 EFC47433.1 - 0.006 16.4 6.5 0.066 13.1 1.7 3.4 2 1 2 4 4 4 2 Shugoshin N-terminal coiled-coil region CENP-H PF05837.12 EFC47433.1 - 0.025 15.0 4.5 0.025 15.0 4.5 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) HAUS6_N PF14661.6 EFC47433.1 - 0.027 14.1 6.5 0.033 13.8 6.5 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus KASH_CCD PF14662.6 EFC47433.1 - 0.039 13.8 22.3 0.026 14.3 19.2 1.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH MAD PF05557.13 EFC47433.1 - 0.04 12.3 20.8 0.13 10.6 20.8 1.7 1 1 0 1 1 1 0 Mitotic checkpoint protein GAS PF13851.6 EFC47433.1 - 0.041 13.2 20.0 0.33 10.3 19.3 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 EFC47433.1 - 0.048 14.1 2.3 0.048 14.1 2.3 3.6 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) Cnn_1N PF07989.11 EFC47433.1 - 0.12 12.5 0.5 0.12 12.5 0.5 4.1 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF2205 PF10224.9 EFC47433.1 - 0.29 11.2 9.8 2.3 8.3 5.1 3.1 2 1 0 2 2 2 0 Short coiled-coil protein NAGLU_N PF12971.7 EFC47433.1 - 0.39 10.5 1.9 1.2 9.0 0.5 2.3 1 1 1 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain HTH_11 PF08279.12 EFC47433.1 - 0.54 10.3 3.0 4.3 7.4 0.2 2.7 2 0 0 2 2 2 0 HTH domain DUF1299 PF06975.11 EFC47433.1 - 0.6 10.2 5.2 18 5.5 0.2 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF1299) PRKG1_interact PF15898.5 EFC47433.1 - 0.7 10.8 15.0 1.8 9.5 0.5 2.5 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YqgF PF14639.6 EFC47433.1 - 1.1 9.1 5.9 0.49 10.2 2.6 1.9 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 DUF3450 PF11932.8 EFC47433.1 - 1.1 8.5 15.4 0.1 11.9 6.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TMPIT PF07851.13 EFC47433.1 - 1.4 8.1 10.9 0.41 9.9 7.8 1.6 1 1 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 EFC47433.1 - 1.7 8.7 25.0 0.47 10.5 13.7 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 EFC47433.1 - 1.7 8.8 23.3 0.17 12.0 4.5 4.6 2 1 3 5 5 5 0 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 EFC47433.1 - 2.1 8.5 20.6 2.1 8.5 2.0 2.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 EFC47433.1 - 2.4 8.3 17.4 8.2 6.6 17.4 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2681 PF10883.8 EFC47433.1 - 4 7.9 18.9 3.7 8.0 5.4 2.8 2 1 2 4 4 3 0 Protein of unknown function (DUF2681) Fib_alpha PF08702.10 EFC47433.1 - 4.4 7.5 13.8 3.6 7.8 7.1 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF724 PF05266.14 EFC47433.1 - 4.6 7.0 18.5 0.87 9.4 10.3 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF724) WD40_alt PF14077.6 EFC47433.1 - 5.9 6.8 10.7 1.5 8.7 1.3 3.0 2 1 1 3 3 2 0 Alternative WD40 repeat motif Syntaxin-6_N PF09177.11 EFC47433.1 - 7.1 7.3 11.2 1 10.0 4.9 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 EFC47433.1 - 7.6 6.6 9.6 6.6 6.8 5.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) IFP_35_N PF07334.13 EFC47433.1 - 9 6.5 17.5 1.9 8.6 3.4 3.4 2 2 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus bZIP_2 PF07716.15 EFC47433.1 - 9 6.5 17.6 0.35 11.0 0.6 4.1 3 1 1 4 4 4 0 Basic region leucine zipper WD40 PF00400.32 EFC47435.1 - 6.9e-20 71.0 12.0 0.00099 19.9 0.5 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47435.1 - 1.9e-06 28.1 5.9 0.13 12.5 0.5 4.6 3 3 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC47435.1 - 2.6e-05 23.3 6.2 0.055 12.4 0.4 3.5 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein YmzC PF14157.6 EFC47435.1 - 0.0022 18.0 0.0 6.2 7.0 0.0 3.7 4 0 0 4 4 4 2 YmzC-like protein eIF2A PF08662.11 EFC47435.1 - 0.034 14.0 2.6 0.13 12.1 0.1 2.8 2 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A DUF5069 PF16798.5 EFC47435.1 - 4.7 7.4 8.1 7.8 6.7 0.4 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5069) CDtoxinA PF03498.14 EFC47436.1 - 0.035 13.7 0.1 0.067 12.8 0.1 1.4 1 0 0 1 1 1 0 Cytolethal distending toxin A/C domain Ricin_B_lectin PF00652.22 EFC47436.1 - 0.089 13.0 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain DUF1310 PF07006.11 EFC47437.1 - 0.036 14.0 0.3 0.079 12.9 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) Metallophos PF00149.28 EFC47438.1 - 9.2e-08 32.8 0.1 1e-07 32.7 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC47438.1 - 0.00014 22.1 0.0 0.00019 21.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Asparaginase_II PF06089.12 EFC47438.1 - 0.16 11.0 0.0 0.21 10.6 0.0 1.1 1 0 0 1 1 1 0 L-asparaginase II ASC PF00858.24 EFC47439.1 - 3.6e-11 42.7 13.2 0.00013 21.1 2.1 3.2 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel TMEM206 PF15122.6 EFC47439.1 - 0.081 12.1 0.1 0.081 12.1 0.1 1.7 2 0 0 2 2 2 0 TMEM206 protein family 2OG-FeII_Oxy_3 PF13640.6 EFC47440.1 - 2.6e-10 41.1 0.0 4.3e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EFC47440.1 - 0.044 14.2 0.0 0.078 13.4 0.0 1.4 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase MMR_HSR1 PF01926.23 EFC47442.1 - 0.00056 20.0 0.0 0.00091 19.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 EFC47442.1 - 0.00064 19.4 0.0 0.06 13.0 0.0 2.1 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain G-alpha PF00503.20 EFC47442.1 - 0.0007 18.8 0.4 0.0055 15.9 0.1 2.0 1 1 1 2 2 2 1 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 EFC47442.1 - 0.0024 17.3 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family RNA_helicase PF00910.22 EFC47442.1 - 0.0042 17.5 0.2 0.0087 16.4 0.0 1.6 2 0 0 2 2 2 1 RNA helicase AAA_18 PF13238.6 EFC47442.1 - 0.0097 16.4 1.2 0.69 10.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AIG1 PF04548.16 EFC47442.1 - 0.01 15.2 0.4 0.04 13.3 0.0 2.1 2 0 0 2 2 2 0 AIG1 family AAA_22 PF13401.6 EFC47442.1 - 0.017 15.4 0.0 0.023 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 EFC47442.1 - 0.03 13.5 0.0 0.04 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) VirE PF05272.11 EFC47442.1 - 0.034 13.9 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 Virulence-associated protein E T2SSE PF00437.20 EFC47442.1 - 0.081 12.0 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 EFC47442.1 - 0.084 13.2 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 EFC47442.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC47444.1 - 0.00012 21.9 0.0 0.00051 19.9 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC47444.1 - 0.0017 18.2 0.0 0.029 14.2 0.0 2.7 3 0 0 3 3 3 1 F-box domain F-box PF00646.33 EFC47445.1 - 2e-05 24.4 0.0 5.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC47445.1 - 3.7e-05 23.5 0.0 7.4e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 F-box-like DUF349 PF03993.12 EFC47445.1 - 5.7 7.3 7.1 3.6 7.9 0.9 2.7 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Frankia_peptide PF14407.6 EFC47446.1 - 0.058 13.4 0.0 0.58 10.2 0.0 2.1 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. FWWh PF14922.6 EFC47447.1 - 0.0058 16.6 0.8 0.013 15.5 0.8 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF4116 PF13475.6 EFC47448.1 - 3.8e-26 90.6 2.4 3.8e-09 36.1 0.0 5.0 5 1 0 5 5 5 4 Domain of unknown function (DUF4116) DUF86 PF01934.17 EFC47449.1 - 0.011 15.7 0.2 0.051 13.4 0.2 2.2 1 0 0 1 1 1 0 Protein of unknown function DUF86 DUF5478 PF17572.2 EFC47449.1 - 0.074 13.2 0.1 26 5.0 0.0 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5478) DUF2570 PF10828.8 EFC47449.1 - 4.3 7.2 6.1 29 4.5 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2570) Peptidase_M49 PF03571.15 EFC47450.1 - 5.8e-203 675.2 1.4 7.6e-203 674.8 1.4 1.1 1 0 0 1 1 1 1 Peptidase family M49 Mucin15 PF15672.5 EFC47450.1 - 0.04 13.4 1.4 0.65 9.4 0.3 2.4 2 1 0 2 2 2 0 Cell-membrane associated Mucin15 MSA-2c PF12238.8 EFC47450.1 - 0.071 13.1 0.7 0.23 11.5 0.0 2.1 3 0 0 3 3 3 0 Merozoite surface antigen 2c TFIIIC_delta PF12657.7 EFC47451.1 - 0.044 13.7 0.5 0.24 11.3 0.5 2.4 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Ribosomal_L2_C PF03947.18 EFC47452.1 - 5.3e-43 146.2 2.3 9.2e-43 145.4 2.3 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 EFC47452.1 - 2.4e-13 49.8 0.0 6.5e-13 48.4 0.0 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain dNK PF01712.19 EFC47453.1 - 3.5e-46 157.6 2.7 4.1e-46 157.4 2.7 1.0 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_18 PF13238.6 EFC47453.1 - 8e-05 23.2 0.1 0.00019 22.0 0.1 1.7 1 1 1 2 2 2 1 AAA domain SKI PF01202.22 EFC47453.1 - 0.005 17.0 0.9 0.045 13.9 0.0 2.5 2 1 1 3 3 3 1 Shikimate kinase Thymidylate_kin PF02223.17 EFC47453.1 - 0.009 15.7 0.0 0.021 14.5 0.0 1.6 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 EFC47453.1 - 0.018 15.2 0.0 0.026 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain PPK2 PF03976.14 EFC47453.1 - 0.019 14.5 0.2 0.031 13.8 0.2 1.3 1 0 0 1 1 1 0 Polyphosphate kinase 2 (PPK2) AAA_17 PF13207.6 EFC47453.1 - 0.052 14.0 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain p450 PF00067.22 EFC47456.1 - 5e-64 216.7 2.4 6.6e-64 216.3 2.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cofilin_ADF PF00241.20 EFC47457.1 - 2.1e-23 82.4 0.7 2.4e-23 82.2 0.7 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SelP_C PF04593.14 EFC47457.1 - 0.0092 16.0 0.6 0.012 15.6 0.6 1.2 1 0 0 1 1 1 1 Selenoprotein P, C terminal region Fz PF01392.22 EFC47459.1 - 8.1e-05 23.2 3.4 8.7e-05 23.1 3.4 1.2 1 0 0 1 1 1 1 Fz domain Form_Nir_trans PF01226.17 EFC47460.1 - 3.1e-08 33.3 0.0 3.9e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter DUF3997 PF13162.6 EFC47460.1 - 0.089 13.1 3.4 0.14 12.4 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3997) DUF2367 PF10164.9 EFC47460.1 - 0.53 10.8 3.7 6 7.4 0.1 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2367) Pkinase PF00069.25 EFC47461.1 - 3.8e-23 82.2 10.4 9.7e-20 71.0 0.5 3.4 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47461.1 - 4.3e-21 75.3 2.5 9e-14 51.4 0.1 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase IQ PF00612.27 EFC47461.1 - 0.0007 19.2 3.1 0.0018 17.9 3.1 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif Kinase-like PF14531.6 EFC47461.1 - 0.0016 17.8 0.1 0.67 9.2 0.0 2.5 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 EFC47461.1 - 0.019 14.3 1.0 1.9 7.8 0.1 3.2 3 1 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family TRAP-gamma PF07074.12 EFC47462.1 - 0.024 14.2 3.8 0.024 14.2 3.8 2.6 1 1 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Phage_holin_3_6 PF07332.11 EFC47462.1 - 6.5 6.8 12.5 12 5.9 7.2 2.4 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III PIH1_CS PF18201.1 EFC47463.1 - 2.2e-12 47.2 0.0 3.4e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain TMEM252 PF15664.5 EFC47463.1 - 0.085 12.6 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 252 family PhyH PF05721.13 EFC47465.1 - 2.3e-09 37.8 0.0 1.7e-06 28.5 0.0 2.3 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFC47465.1 - 7.6e-07 28.2 0.0 3.5e-05 22.8 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 EFC47465.1 - 0.01 16.2 0.0 0.021 15.2 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 EFC47465.1 - 0.15 12.9 0.0 0.27 12.2 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily LD_cluster3 PF18180.1 EFC47465.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster3 family PRCC PF10253.9 EFC47467.1 - 1.4e-06 29.2 23.3 0.00024 22.0 23.3 2.4 1 1 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting RNA_pol_3_Rpc31 PF11705.8 EFC47467.1 - 0.00014 22.2 7.1 0.00014 22.2 7.1 2.9 3 0 0 3 3 3 1 DNA-directed RNA polymerase III subunit Rpc31 Serinc PF03348.15 EFC47467.1 - 0.52 9.2 2.8 0.87 8.4 2.8 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) CCG PF02754.16 EFC47468.1 - 1.1e-08 35.1 2.0 1.2e-06 28.6 0.0 3.4 3 0 0 3 3 3 1 Cysteine-rich domain Fer4_21 PF14697.6 EFC47468.1 - 0.0019 18.3 6.2 0.0068 16.5 6.2 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 EFC47468.1 - 0.0022 18.6 5.0 0.0089 16.6 5.0 2.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFC47468.1 - 0.0062 16.7 5.8 0.025 14.7 6.0 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFC47468.1 - 0.02 15.0 9.7 0.046 13.8 8.4 2.4 2 1 1 3 3 2 0 4Fe-4S dicluster domain DUF2960 PF11173.8 EFC47468.1 - 0.052 14.0 0.2 57 4.3 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2960) Fer4_17 PF13534.6 EFC47468.1 - 0.1 13.1 9.9 0.85 10.2 9.6 2.6 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_4 PF12800.7 EFC47468.1 - 0.16 12.5 9.6 1.4 9.6 2.0 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_6 PF12837.7 EFC47468.1 - 0.3 11.2 13.6 0.95 9.6 3.2 2.9 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_16 PF13484.6 EFC47468.1 - 0.31 12.0 4.9 5.1 8.1 0.2 3.2 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain Fer4_8 PF13183.6 EFC47468.1 - 0.78 10.2 13.1 1 9.8 10.0 2.7 2 1 1 3 3 3 0 4Fe-4S dicluster domain Mut7-C PF01927.16 EFC47468.1 - 0.92 9.6 3.7 1.4 9.0 1.8 2.2 2 0 0 2 2 2 0 Mut7-C RNAse domain Fer4 PF00037.27 EFC47468.1 - 1.5 8.8 12.9 2 8.4 0.6 2.9 3 0 0 3 3 3 0 4Fe-4S binding domain EF-hand_6 PF13405.6 EFC47469.1 - 1.2e-10 40.4 11.2 0.00014 21.5 0.3 4.6 5 0 0 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 EFC47469.1 - 6e-08 33.0 11.9 0.0017 18.8 0.2 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC47469.1 - 1.9e-06 27.0 8.4 0.0034 16.8 0.2 4.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EFC47469.1 - 3.7e-06 26.7 6.8 0.00025 20.8 0.0 3.8 3 2 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 EFC47469.1 - 0.021 15.2 3.7 0.1 13.0 0.1 3.3 4 0 0 4 4 4 0 EF-hand domain CutA1 PF03091.15 EFC47469.1 - 0.12 12.2 0.0 0.37 10.7 0.0 1.8 2 0 0 2 2 2 0 CutA1 divalent ion tolerance protein Peptidase_Mx1 PF15890.5 EFC47469.1 - 0.17 11.3 5.2 1.8 7.9 5.2 2.1 1 1 0 1 1 1 0 Putative zinc-binding metallo-peptidase RP-C_C PF11800.8 EFC47469.1 - 0.35 10.9 1.3 0.51 10.4 1.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region EF-hand_5 PF13202.6 EFC47469.1 - 1.8 8.2 6.8 1.5 8.5 0.2 3.6 4 0 0 4 4 4 0 EF hand IBB PF01749.20 EFC47469.1 - 2.1 8.8 4.2 3.7 8.0 2.2 2.2 2 0 0 2 2 2 0 Importin beta binding domain RasGEF PF00617.19 EFC47471.1 - 1.4e-43 149.2 0.9 1.4e-43 149.2 0.9 3.7 3 2 0 3 3 3 1 RasGEF domain PQ-loop PF04193.14 EFC47473.1 - 3.1e-34 116.5 13.3 2.2e-18 65.8 3.7 2.8 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 EFC47473.1 - 0.012 15.7 0.2 0.012 15.7 0.2 2.3 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange YrhC PF14143.6 EFC47473.1 - 0.13 12.3 4.7 8.7 6.5 0.0 4.0 4 0 0 4 4 4 0 YrhC-like protein ER_lumen_recept PF00810.18 EFC47473.1 - 0.23 12.3 5.2 0.59 11.0 0.0 2.9 1 1 2 3 3 3 0 ER lumen protein retaining receptor UNC-50 PF05216.13 EFC47473.1 - 1.9 8.0 6.5 1.8 8.1 4.0 2.1 2 1 0 2 2 2 0 UNC-50 family DUF3169 PF11368.8 EFC47473.1 - 6.4 6.2 7.6 0.22 11.0 0.3 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3169) Actin PF00022.19 EFC47474.1 - 7e-45 153.3 0.0 3.1e-42 144.6 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC47474.1 - 0.00076 18.4 0.0 0.0086 14.9 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Pkinase PF00069.25 EFC47475.1 - 1.3e-21 77.2 0.0 1.4e-21 77.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47475.1 - 2.1e-15 56.7 0.0 2.3e-15 56.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC47475.1 - 0.00012 21.1 0.0 0.00012 21.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC47475.1 - 0.038 13.9 0.1 0.051 13.5 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC47475.1 - 0.17 10.7 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pkinase PF00069.25 EFC47476.1 - 2.4e-32 112.4 1.6 2.6e-32 112.2 1.6 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47476.1 - 2e-19 69.9 0.2 2.2e-19 69.7 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.9 EFC47476.1 - 0.00021 20.8 0.4 0.00026 20.5 0.4 1.4 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EFC47476.1 - 0.0026 16.6 2.3 0.0035 16.2 0.3 1.9 1 1 1 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFC47476.1 - 0.0065 15.9 0.1 0.009 15.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC47476.1 - 0.043 13.7 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BTB_2 PF02214.22 EFC47478.1 - 5.6e-11 42.6 5.2 5.3e-05 23.5 0.0 3.5 3 0 0 3 3 3 2 BTB/POZ domain EF1_GNE PF00736.19 EFC47478.1 - 0.026 14.7 0.1 0.11 12.6 0.1 2.1 1 0 0 1 1 1 0 EF-1 guanine nucleotide exchange domain Polbeta PF18765.1 EFC47478.1 - 0.057 13.5 0.5 0.41 10.8 0.1 2.7 3 0 0 3 3 3 0 Polymerase beta, Nucleotidyltransferase Arf PF00025.21 EFC47479.1 - 6.5e-65 217.8 0.1 7.3e-65 217.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC47479.1 - 6.3e-14 51.9 0.0 6.9e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC47479.1 - 3e-13 49.7 1.4 1.1e-10 41.2 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC47479.1 - 3.6e-13 49.3 0.1 4.5e-13 49.0 0.1 1.0 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC47479.1 - 2.1e-12 47.3 0.2 3e-12 46.8 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC47479.1 - 5.7e-09 35.7 0.1 7.3e-09 35.3 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC47479.1 - 0.00093 19.3 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF1015 PF06245.11 EFC47479.1 - 0.053 12.4 0.0 0.064 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) Vmethyltransf PF01660.17 EFC47479.1 - 0.084 11.7 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase DUF3913 PF13052.6 EFC47479.1 - 0.11 12.8 0.0 1.6 9.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3913) F-box-like PF12937.7 EFC47480.1 - 2.1e-07 30.7 0.0 3.5e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 F-box-like GON PF08685.11 EFC47480.1 - 2.2e-07 30.9 6.7 4.3e-07 30.0 6.7 1.5 1 1 0 1 1 1 1 GON domain F-box PF00646.33 EFC47480.1 - 0.0077 16.1 0.1 0.013 15.4 0.1 1.4 1 0 0 1 1 1 1 F-box domain Ammonium_transp PF00909.21 EFC47481.1 - 4.3e-110 368.1 26.4 5e-110 367.9 26.4 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Trp_oprn_chp PF09534.10 EFC47481.1 - 0.64 9.8 0.0 0.64 9.8 0.0 3.0 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ank_2 PF12796.7 EFC47482.1 - 8.5e-31 106.4 0.0 7.9e-13 48.8 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC47482.1 - 3e-17 62.8 0.0 6.1e-07 29.9 0.0 3.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC47482.1 - 1.8e-16 59.9 0.0 1.2e-11 44.5 0.0 3.2 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC47482.1 - 2.9e-15 54.8 0.0 0.008 16.6 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 EFC47482.1 - 1.9e-14 53.3 0.0 0.00049 20.4 0.0 4.8 4 1 1 5 5 5 3 Ankyrin repeat DHR-2 PF06920.13 EFC47483.1 - 3.8e-43 147.9 46.4 2.1e-25 89.4 28.4 4.0 3 1 0 3 3 3 2 Dock homology region 2 DOCK-C2 PF14429.6 EFC47483.1 - 2.6e-16 60.0 0.8 2.6e-16 60.0 0.8 3.3 5 0 0 5 5 5 1 C2 domain in Dock180 and Zizimin proteins SH3_9 PF14604.6 EFC47483.1 - 0.015 15.2 0.0 0.039 13.8 0.0 1.7 1 0 0 1 1 1 0 Variant SH3 domain C2 PF00168.30 EFC47483.1 - 0.026 14.8 0.1 0.11 12.8 0.1 2.1 1 1 0 1 1 1 0 C2 domain DUF1993 PF09351.10 EFC47483.1 - 0.32 11.1 3.9 0.21 11.7 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) DUF1664 PF07889.12 EFC47483.1 - 1.6 8.8 5.5 1.3 9.1 0.2 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) adh_short_C2 PF13561.6 EFC47484.1 - 5.8e-44 150.4 0.0 7.4e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 EFC47484.1 - 1.7e-34 119.0 0.1 2.1e-34 118.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 EFC47484.1 - 2e-05 24.6 0.0 2.7e-05 24.1 0.0 1.3 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC47484.1 - 0.063 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein CUE PF02845.16 EFC47485.1 - 2.9e-08 33.2 2.2 2.9e-08 33.2 2.2 3.1 3 0 0 3 3 3 1 CUE domain IBR PF01485.21 EFC47485.1 - 9.4e-07 29.0 17.8 9.4e-07 29.0 17.8 4.2 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 EFC47485.1 - 0.0012 18.7 6.3 0.0012 18.7 6.3 3.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) SRP9-21 PF05486.12 EFC47487.1 - 3.1e-09 37.1 0.7 9.9e-08 32.3 0.7 2.2 1 1 0 1 1 1 1 Signal recognition particle 9 kDa protein (SRP9) DUF5611 PF18446.1 EFC47487.1 - 0.026 15.4 2.3 0.034 15.0 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5611) Phage_TTP_1 PF04630.12 EFC47488.1 - 0.012 15.0 0.2 0.019 14.3 0.2 1.2 1 0 0 1 1 1 0 Phage tail tube protein Abhydrolase_6 PF12697.7 EFC47488.1 - 0.012 16.2 0.0 0.017 15.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC47488.1 - 0.018 14.3 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF676 PF05057.14 EFC47488.1 - 0.052 13.1 0.4 0.1 12.1 0.1 1.6 2 0 0 2 2 2 0 Putative serine esterase (DUF676) Lipase_3 PF01764.25 EFC47488.1 - 0.052 13.4 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) GIY-YIG PF01541.24 EFC47488.1 - 0.18 12.1 1.5 0.49 10.7 0.5 2.2 2 0 0 2 2 2 0 GIY-YIG catalytic domain FdsD PF11390.8 EFC47491.1 - 0.011 16.0 0.3 11 6.5 0.0 3.7 3 0 0 3 3 3 0 NADH-dependant formate dehydrogenase delta subunit FdsD Arf PF00025.21 EFC47492.1 - 3.1e-13 49.6 0.0 3.3e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Peptidase_C39_2 PF13529.6 EFC47494.1 - 3.5e-10 40.6 0.0 8.4e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 EFC47494.1 - 0.037 14.0 0.0 0.066 13.2 0.0 1.4 1 1 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 Abhydrolase_1 PF00561.20 EFC47495.1 - 0.033 13.9 0.0 7.8 6.1 0.0 2.6 3 0 0 3 3 3 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC47495.1 - 0.06 12.6 0.0 5.3 6.2 0.0 2.4 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF4116 PF13475.6 EFC47496.1 - 2.8e-43 145.4 26.4 6e-14 51.5 0.0 11.9 8 2 3 12 12 12 8 Domain of unknown function (DUF4116) DUF4116 PF13475.6 EFC47497.1 - 9.7e-12 44.4 9.0 8.6e-08 31.8 0.0 5.0 5 0 0 5 5 5 2 Domain of unknown function (DUF4116) F-box PF00646.33 EFC47497.1 - 0.035 14.0 0.5 0.27 11.1 0.1 2.5 2 0 0 2 2 2 0 F-box domain NAD_binding_10 PF13460.6 EFC47498.1 - 3.2e-08 33.7 0.0 5.1e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC47498.1 - 3.5e-08 33.3 0.1 5.3e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 EFC47498.1 - 0.001 18.6 0.1 0.13 11.7 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 EFC47498.1 - 0.0012 18.1 0.0 0.002 17.3 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein KR PF08659.10 EFC47498.1 - 0.01 15.7 0.0 0.023 14.6 0.0 1.6 2 0 0 2 2 2 0 KR domain Epimerase PF01370.21 EFC47498.1 - 0.046 13.2 0.0 0.85 9.0 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 EFC47498.1 - 0.088 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Lsm_interact PF05391.11 EFC47499.1 - 1.8 8.2 5.4 0.59 9.7 1.4 2.3 2 0 0 2 2 2 0 Lsm interaction motif EGF_2 PF07974.13 EFC47500.1 - 4.2e-66 218.9 342.3 1.8e-05 25.0 10.1 19.5 19 0 0 19 19 19 19 EGF-like domain RGS PF00615.19 EFC47500.1 - 0.00021 21.5 1.2 0.00063 20.0 1.2 1.9 1 0 0 1 1 1 1 Regulator of G protein signaling domain FliG_N PF14842.6 EFC47500.1 - 0.006 17.1 0.1 0.014 15.9 0.1 1.6 1 0 0 1 1 1 1 FliG N-terminal domain Bacteriocin_IId PF09221.10 EFC47500.1 - 0.042 14.0 0.2 0.042 14.0 0.2 3.5 4 0 0 4 4 4 0 Bacteriocin class IId cyclical uberolysin-like MORN PF02493.20 EFC47500.1 - 0.48 10.4 2.1 11 6.2 0.0 4.5 6 0 0 6 6 6 0 MORN repeat GBP PF02263.19 EFC47501.1 - 1.9e-48 165.0 1.6 1.9e-48 165.0 1.6 2.3 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain ApoO PF09769.9 EFC47501.1 - 0.013 15.4 7.2 0.032 14.2 3.5 2.6 2 0 0 2 2 2 0 Apolipoprotein O MMR_HSR1 PF01926.23 EFC47501.1 - 0.17 12.0 2.3 0.54 10.4 0.0 2.9 3 2 0 3 3 3 0 50S ribosome-binding GTPase DUF4407 PF14362.6 EFC47501.1 - 1.5 8.1 8.9 3.2 7.0 8.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AI-2E_transport PF01594.16 EFC47501.1 - 2.7 7.0 9.6 18 4.4 5.1 2.5 2 0 0 2 2 2 0 AI-2E family transporter FliT PF05400.13 EFC47501.1 - 9.6 7.1 15.0 94 3.9 11.1 2.8 2 0 0 2 2 2 0 Flagellar protein FliT DUF3025 PF11227.8 EFC47502.1 - 4.7e-38 131.1 0.1 7.9e-38 130.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3025) Ank_2 PF12796.7 EFC47504.1 - 1.2e-20 73.8 15.8 4e-07 30.5 0.4 5.2 2 2 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47504.1 - 2.5e-14 52.0 7.7 0.027 15.0 0.0 8.1 8 0 0 8 8 8 3 Ankyrin repeat Ank_4 PF13637.6 EFC47504.1 - 6.8e-13 48.9 12.2 0.014 16.0 0.1 6.4 4 3 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC47504.1 - 2e-10 40.6 2.5 0.0059 17.0 0.0 6.1 6 0 0 6 6 6 1 Ankyrin repeat Hemerythrin PF01814.23 EFC47504.1 - 1.5e-09 38.6 1.9 5.4e-09 36.8 1.9 2.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Ank_5 PF13857.6 EFC47504.1 - 1.6e-09 37.8 4.3 0.28 11.5 0.0 6.7 3 2 4 7 7 7 3 Ankyrin repeats (many copies) 4HB_MCP_1 PF12729.7 EFC47504.1 - 0.0057 16.2 5.3 0.0057 16.2 5.3 2.0 2 0 0 2 2 2 1 Four helix bundle sensory module for signal transduction AnkUBD PF18418.1 EFC47504.1 - 0.1 12.8 1.6 0.16 12.1 0.0 2.2 2 0 0 2 2 2 0 Ankyrin ubiquitin-binding domain DUSP PF06337.12 EFC47504.1 - 0.2 12.3 5.7 0.68 10.6 1.7 3.1 2 0 0 2 2 2 0 DUSP domain XS PF03468.14 EFC47504.1 - 0.27 11.5 0.1 0.27 11.5 0.1 2.4 2 0 0 2 2 2 0 XS domain Ribosomal_L21e PF01157.18 EFC47505.1 - 3.7e-38 129.4 2.8 5.6e-38 128.9 2.8 1.3 1 0 0 1 1 1 1 Ribosomal protein L21e CASP_C PF08172.12 EFC47506.1 - 0.017 14.5 0.1 0.017 14.5 0.1 2.2 2 0 0 2 2 2 0 CASP C terminal Pkinase PF00069.25 EFC47507.1 - 1.2e-40 139.5 0.0 1.5e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47507.1 - 3.3e-38 131.4 0.0 3.8e-38 131.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC47507.1 - 8.5e-05 22.6 0.0 0.00024 21.1 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC47507.1 - 0.0024 16.9 0.0 0.0075 15.3 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain PIP49_N PF14875.6 EFC47507.1 - 0.017 15.0 0.0 0.023 14.6 0.0 1.2 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 Fructosamin_kin PF03881.14 EFC47507.1 - 0.13 11.4 0.0 8.2 5.5 0.0 2.1 1 1 1 2 2 2 0 Fructosamine kinase FTA2 PF13095.6 EFC47507.1 - 0.16 11.6 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 NHL PF01436.21 EFC47508.1 - 0.021 14.9 0.8 1.7 8.9 0.0 3.3 3 0 0 3 3 3 0 NHL repeat 2_5_RNA_ligase2 PF13563.6 EFC47508.1 - 0.049 13.6 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily Phospholip_B PF04916.13 EFC47509.1 - 5.5e-160 533.4 5.2 6.8e-160 533.1 5.2 1.0 1 0 0 1 1 1 1 Phospholipase B MKT1_C PF12246.8 EFC47509.1 - 0.017 14.4 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication RPAP3_C PF13877.6 EFC47510.1 - 0.022 15.3 8.1 0.3 11.7 0.3 3.4 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 RNA_pol_Rpb1_7 PF04990.12 EFC47510.1 - 0.11 12.4 3.5 11 6.0 0.6 3.0 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 7 TetR_C_8 PF14278.6 EFC47510.1 - 6.3 7.0 11.9 0.37 10.9 0.4 4.4 4 0 0 4 4 4 0 Transcriptional regulator C-terminal region DUF4116 PF13475.6 EFC47511.1 - 9.5e-32 108.5 54.1 6.1e-06 25.9 5.2 12.7 12 1 1 13 13 13 10 Domain of unknown function (DUF4116) tRNA_synt_2f PF02092.17 EFC47511.1 - 0.019 13.9 0.1 0.031 13.2 0.1 1.2 1 0 0 1 1 1 0 Glycyl-tRNA synthetase beta subunit NHL PF01436.21 EFC47512.1 - 7.3e-52 170.9 0.1 7.2e-06 25.8 0.0 14.8 15 0 0 15 15 15 9 NHL repeat SGL PF08450.12 EFC47512.1 - 1.8e-13 50.6 1.4 0.054 13.1 0.2 6.8 4 2 1 6 6 6 4 SMP-30/Gluconolactonase/LRE-like region EGF_2 PF07974.13 EFC47512.1 - 5.6e-05 23.4 9.9 0.00013 22.2 9.9 1.6 1 0 0 1 1 1 1 EGF-like domain GPS PF01825.21 EFC47512.1 - 0.0069 16.9 0.0 0.0069 16.9 0.0 2.5 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif EGF PF00008.27 EFC47512.1 - 0.27 11.6 4.2 0.76 10.1 4.2 1.8 1 0 0 1 1 1 0 EGF-like domain EGF_Tenascin PF18720.1 EFC47512.1 - 5.3 7.2 13.7 21 5.3 13.7 2.1 1 0 0 1 1 1 0 Tenascin EGF domain ubiquitin PF00240.23 EFC47513.1 - 9.2e-18 63.8 0.0 1e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC47513.1 - 8.3e-07 28.7 0.0 9.1e-07 28.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC47513.1 - 0.027 14.9 0.0 0.18 12.2 0.0 1.9 1 1 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC47513.1 - 0.07 13.2 0.0 0.51 10.5 0.0 1.9 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ADP_ribosyl_GH PF03747.14 EFC47515.1 - 2.6e-42 145.5 0.0 3.1e-42 145.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Swm2 PF17083.5 EFC47515.1 - 0.032 14.2 1.8 0.04 13.9 0.5 1.8 2 0 0 2 2 2 0 Nucleolar protein Swm2 PAP_central PF04928.17 EFC47515.1 - 0.041 12.8 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 Poly(A) polymerase central domain LRR_4 PF12799.7 EFC47517.1 - 2e-18 66.2 45.4 8.8e-05 22.8 0.1 7.6 3 3 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC47517.1 - 7.4e-09 35.0 35.0 0.00023 21.0 0.1 8.3 9 0 0 9 9 9 5 Leucine Rich repeat LRR_8 PF13855.6 EFC47517.1 - 4.5e-08 32.7 35.8 0.0017 18.1 1.4 7.0 3 3 2 5 5 5 5 Leucine rich repeat LRR_1 PF00560.33 EFC47517.1 - 0.00026 21.1 37.3 1.3 9.8 0.1 9.5 9 0 0 9 9 9 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC47517.1 - 0.0013 18.3 14.8 0.19 11.2 0.3 3.8 1 1 1 3 3 3 2 Leucine-rich repeat PRESAN PF09687.10 EFC47517.1 - 0.012 16.2 1.0 0.012 16.2 1.0 2.3 2 0 0 2 2 2 0 Plasmodium RESA N-terminal RGS PF00615.19 EFC47518.1 - 5.6e-05 23.4 0.1 0.00018 21.8 0.1 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF4507 PF14964.6 EFC47518.1 - 0.0037 16.2 0.1 0.0047 15.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4507) GNAT_acetyltran PF12746.7 EFC47519.1 - 0.079 12.5 0.5 0.24 10.9 0.3 1.9 2 0 0 2 2 2 0 GNAT acetyltransferase RGS PF00615.19 EFC47519.1 - 0.25 11.6 5.3 1.1 9.5 2.2 2.8 2 1 0 2 2 2 0 Regulator of G protein signaling domain TctB PF07331.11 EFC47520.1 - 0.0048 17.2 18.1 0.16 12.3 2.3 3.4 1 1 1 2 2 2 1 Tripartite tricarboxylate transporter TctB family TMEM132D_C PF15706.5 EFC47520.1 - 0.05 13.4 2.1 0.17 11.7 0.1 2.7 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term COA2 PF17051.5 EFC47520.1 - 0.17 12.0 0.5 0.65 10.1 0.5 2.0 1 0 0 1 1 1 0 Cytochrome C oxidase assembly factor 2 DUF2207 PF09972.9 EFC47521.1 - 2.1e-07 30.1 0.7 2.9e-07 29.6 0.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Crystall_2 PF09076.10 EFC47521.1 - 0.046 13.6 0.3 0.046 13.6 0.3 2.1 2 0 0 2 2 2 0 Beta/Gamma crystallin RCC1 PF00415.18 EFC47522.1 - 4.8e-40 135.9 9.3 1.9e-12 47.6 0.0 7.8 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC47522.1 - 1.3e-24 85.4 26.3 3.5e-07 29.9 0.1 7.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC47523.1 - 1.8e-38 132.4 0.8 3e-38 131.7 0.8 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47523.1 - 9.9e-18 64.3 0.0 3.1e-16 59.4 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 EFC47523.1 - 6.2e-05 22.7 0.0 0.11 12.2 0.0 2.6 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 EFC47523.1 - 0.00012 21.5 0.0 0.00022 20.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like dsrm PF00035.26 EFC47523.1 - 0.0016 19.1 0.0 0.0041 17.8 0.0 1.7 1 0 0 1 1 1 1 Double-stranded RNA binding motif Pkinase_fungal PF17667.1 EFC47523.1 - 0.0025 16.6 0.0 0.0049 15.7 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFC47523.1 - 0.0098 15.5 0.0 0.059 13.0 0.0 2.3 3 0 0 3 3 3 1 RIO1 family Kdo PF06293.14 EFC47523.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC47523.1 - 0.021 14.8 0.0 0.032 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family HmuY PF14064.6 EFC47523.1 - 0.14 12.4 0.4 3.4 7.9 0.1 2.7 2 1 0 2 2 2 0 HmuY protein FA_desaturase PF00487.24 EFC47525.1 - 2.4e-33 116.1 24.4 2.4e-33 116.1 24.4 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFC47525.1 - 2.6e-19 69.1 0.0 4.8e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Transferase PF02458.15 EFC47526.1 - 6.3e-10 38.3 0.0 1.3e-09 37.3 0.0 1.4 1 1 0 1 1 1 1 Transferase family HIT PF01230.23 EFC47527.1 - 2.4e-19 69.9 0.1 2.7e-19 69.7 0.1 1.0 1 0 0 1 1 1 1 HIT domain DUF4931 PF16285.5 EFC47527.1 - 6.6e-07 28.9 0.1 7.7e-07 28.7 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) DcpS_C PF11969.8 EFC47527.1 - 7.2e-07 29.7 0.1 8.9e-07 29.4 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 EFC47527.1 - 0.0005 19.9 0.1 0.00062 19.6 0.1 1.1 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 TMEM52 PF14979.6 EFC47528.1 - 0.0087 16.0 0.1 0.018 15.0 0.1 1.6 1 1 0 1 1 1 1 Transmembrane 52 EphA2_TM PF14575.6 EFC47528.1 - 0.018 15.9 1.1 0.073 14.0 0.0 2.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SID-1_RNA_chan PF13965.6 EFC47528.1 - 0.019 13.4 0.3 0.035 12.5 0.2 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 TraS PF10624.9 EFC47528.1 - 0.023 14.6 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Plasmid conjugative transfer entry exclusion protein TraS CcmH PF03918.14 EFC47528.1 - 0.042 13.2 0.0 0.089 12.1 0.0 1.6 1 0 0 1 1 1 0 Cytochrome C biogenesis protein TMEM154 PF15102.6 EFC47528.1 - 0.052 13.5 0.1 0.052 13.5 0.1 2.1 2 0 0 2 2 2 0 TMEM154 protein family Guanylate_cyc PF00211.20 EFC47529.1 - 1.9e-50 171.1 0.3 3.4e-50 170.2 0.3 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC47529.1 - 2.3e-12 47.1 0.1 1e-11 45.0 0.1 2.3 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC47529.1 - 2.8e-06 27.3 0.0 7.8e-06 25.9 0.0 1.9 1 0 0 1 1 1 1 PAS fold Ank_2 PF12796.7 EFC47529.1 - 2.6e-05 24.7 0.1 0.41 11.3 0.0 5.3 4 1 1 5 5 5 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC47529.1 - 0.00071 20.1 0.7 1.4 9.6 0.0 3.5 3 0 0 3 3 2 2 Ankyrin repeats (many copies) HNOBA PF07701.14 EFC47529.1 - 0.0073 15.8 0.3 0.0073 15.8 0.3 2.0 2 0 0 2 2 2 1 Heme NO binding associated PAS_4 PF08448.10 EFC47529.1 - 0.013 15.8 0.0 0.023 14.9 0.0 1.4 1 0 0 1 1 1 0 PAS fold PAS_10 PF13596.6 EFC47529.1 - 0.016 15.8 0.0 0.076 13.6 0.0 2.3 1 0 0 1 1 1 0 PAS domain Ank_3 PF13606.6 EFC47529.1 - 0.02 15.4 1.7 62 4.7 0.0 5.3 4 0 0 4 4 4 0 Ankyrin repeat PAS_8 PF13188.7 EFC47529.1 - 0.049 13.7 0.0 0.16 12.0 0.0 1.9 1 0 0 1 1 1 0 PAS domain dsDNA_bind PF01984.20 EFC47529.1 - 0.082 13.2 0.0 0.082 13.2 0.0 3.0 3 0 0 3 3 2 0 Double-stranded DNA-binding domain Ank_5 PF13857.6 EFC47529.1 - 0.15 12.4 0.1 24 5.4 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Guanylate_cyc PF00211.20 EFC47530.1 - 4.8e-52 176.3 0.3 1e-51 175.2 0.3 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC47530.1 - 2.8e-12 46.8 0.2 1.3e-11 44.6 0.0 2.3 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC47530.1 - 3.8e-06 26.9 0.0 1.2e-05 25.3 0.0 1.9 1 0 0 1 1 1 1 PAS fold HNOBA PF07701.14 EFC47530.1 - 0.0022 17.5 0.3 0.0047 16.4 0.3 1.6 1 0 0 1 1 1 1 Heme NO binding associated PAS_8 PF13188.7 EFC47530.1 - 0.019 15.0 0.0 0.062 13.3 0.0 1.9 1 0 0 1 1 1 0 PAS domain dsDNA_bind PF01984.20 EFC47530.1 - 0.02 15.2 0.0 0.052 13.8 0.0 1.7 1 0 0 1 1 1 0 Double-stranded DNA-binding domain PAS_10 PF13596.6 EFC47530.1 - 0.04 14.5 0.0 0.19 12.4 0.0 2.2 2 0 0 2 2 2 0 PAS domain PAS_4 PF08448.10 EFC47530.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 PAS fold ASXH PF13919.6 EFC47530.1 - 0.17 11.9 0.9 4.8 7.2 2.1 2.6 2 0 0 2 2 2 0 Asx homology domain T4_Rnl2_C PF18043.1 EFC47530.1 - 0.56 10.4 5.1 2.2 8.5 0.4 3.1 3 0 0 3 3 3 0 T4 RNA ligase 2 C-terminal PHO4 PF01384.20 EFC47531.1 - 1.2e-107 359.9 15.8 1.4e-107 359.6 15.8 1.0 1 0 0 1 1 1 1 Phosphate transporter family Prominin PF05478.11 EFC47531.1 - 0.22 9.4 4.3 0.35 8.8 4.3 1.3 1 0 0 1 1 1 0 Prominin DUF4845 PF16137.5 EFC47531.1 - 1.6 9.7 4.2 1.7 9.6 2.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4845) DUF4179 PF13786.6 EFC47532.1 - 0.00046 20.6 2.4 0.0047 17.4 1.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4179) DUF2970 PF11174.8 EFC47532.1 - 0.058 13.3 4.7 0.25 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) ETRAMP PF09716.10 EFC47532.1 - 0.12 12.4 2.8 0.11 12.6 1.0 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DAG1 PF05454.11 EFC47532.1 - 0.2 11.0 10.2 0.9 8.9 1.3 2.8 2 1 1 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF3040 PF11239.8 EFC47532.1 - 0.21 11.9 1.3 4.5 7.6 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF2207 PF09972.9 EFC47532.1 - 1.8 7.2 4.0 4.9 5.8 0.1 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) OmdA PF13376.6 EFC47533.1 - 1.3e-17 63.6 0.5 1.3e-17 63.6 0.5 2.3 2 0 0 2 2 2 1 Bacteriocin-protection, YdeI or OmpD-Associated WAC_Acf1_DNA_bd PF10537.9 EFC47533.1 - 0.13 12.8 2.0 5.1 7.7 0.6 2.6 1 1 1 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal ERp29 PF07749.12 EFC47533.1 - 0.4 11.6 6.0 0.25 12.3 1.4 2.7 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain TarH PF02203.15 EFC47533.1 - 0.45 10.4 2.5 3.5 7.5 0.1 2.3 2 0 0 2 2 2 0 Tar ligand binding domain homologue DUF5024 PF16427.5 EFC47533.1 - 0.55 10.6 6.7 5.6 7.3 0.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5024) COesterase PF00135.28 EFC47534.1 - 4.3e-95 319.5 5.3 5e-95 319.3 5.3 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFC47534.1 - 3.5e-08 33.5 0.4 0.0004 20.3 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Vps23_core PF09454.10 EFC47535.1 - 0.067 13.2 0.1 7 6.7 0.0 3.0 2 0 0 2 2 2 0 Vps23 core domain LMBR1 PF04791.16 EFC47535.1 - 5.2 5.9 16.8 0.11 11.4 5.3 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4116 PF13475.6 EFC47536.1 - 4.5e-129 420.1 2.7 3.6e-16 58.6 0.1 11.2 7 1 5 13 13 13 12 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC47536.1 - 4e-29 101.8 0.2 4e-29 101.8 0.2 2.3 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47536.1 - 6.8e-20 71.4 0.0 2.2e-19 69.8 0.0 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4853 PF16145.5 EFC47536.1 - 0.0025 18.0 1.5 6.6 6.9 0.1 4.9 1 1 4 5 5 5 1 Domain of unknown function (DUF4853) GST_C PF00043.25 EFC47536.1 - 0.71 10.1 6.1 15 5.9 0.1 4.8 4 1 0 4 4 4 0 Glutathione S-transferase, C-terminal domain DUF150_C PF17384.2 EFC47536.1 - 0.81 9.9 6.2 14 5.9 0.2 4.0 3 1 0 3 3 3 0 RimP C-terminal SH3 domain TLD PF07534.16 EFC47537.1 - 1.1e-22 80.7 1.8 1.7e-22 80.1 1.8 1.3 1 0 0 1 1 1 1 TLD LANC_like PF05147.13 EFC47538.1 - 1.5e-50 171.7 1.6 5.9e-49 166.5 1.3 2.0 2 0 0 2 2 2 2 Lanthionine synthetase C-like protein Glyco_hydro_88 PF07470.13 EFC47538.1 - 0.00025 20.3 0.0 0.00074 18.7 0.0 1.8 1 1 1 2 2 2 1 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 EFC47538.1 - 0.046 13.2 0.0 0.14 11.7 0.0 1.8 1 0 0 1 1 1 0 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 EFC47538.1 - 0.089 11.3 0.0 0.2 10.1 0.0 1.6 1 1 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 dCache_1 PF02743.18 EFC47539.1 - 0.0025 17.7 9.2 0.015 15.1 9.2 2.1 1 1 0 1 1 1 1 Cache domain QIL1 PF15884.5 EFC47539.1 - 0.047 14.3 0.4 24 5.6 0.0 4.1 4 0 0 4 4 4 0 MICOS complex subunit MIC13, QIL1 PsbI PF02532.14 EFC47539.1 - 2.6 8.1 5.8 96 3.0 0.0 3.5 3 0 0 3 3 3 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Mito_carr PF00153.27 EFC47542.1 - 3.5e-07 30.0 0.1 0.0043 16.9 0.0 3.3 3 0 0 3 3 3 2 Mitochondrial carrier protein CRM1_C PF08767.11 EFC47542.1 - 0.062 12.5 0.1 0.44 9.7 0.0 2.0 2 0 0 2 2 2 0 CRM1 C terminal Pyr_redox_2 PF07992.14 EFC47543.1 - 7.7e-45 153.4 0.0 1e-44 152.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFC47543.1 - 9.4e-28 96.7 0.2 1.7e-27 95.9 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFC47543.1 - 2.8e-14 53.4 0.0 1.9e-12 47.5 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC47543.1 - 2.8e-05 23.4 0.1 0.14 11.3 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 EFC47543.1 - 7.2e-05 22.2 0.1 0.00075 18.9 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC47543.1 - 0.17 11.4 0.0 5.8 6.4 0.0 2.7 2 1 1 3 3 3 0 FAD dependent oxidoreductase F-box-like PF12937.7 EFC47545.1 - 3.4e-07 30.0 0.2 8.3e-07 28.8 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC47545.1 - 5.4e-06 26.2 0.1 1.8e-05 24.5 0.1 1.8 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 EFC47545.1 - 1.2 9.0 8.6 0.53 10.1 0.1 4.2 4 0 0 4 4 4 0 Leucine rich repeat CTP_transf_like PF01467.26 EFC47546.1 - 1.3e-07 31.9 0.0 2.3e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 Cytidylyltransferase-like Ank_5 PF13857.6 EFC47547.1 - 2.7e-09 37.1 0.0 0.008 16.5 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC47547.1 - 6.6e-09 36.2 0.1 0.018 15.6 0.1 3.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47547.1 - 3.9e-06 26.8 0.5 0.1 13.2 0.1 4.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFC47547.1 - 0.00065 20.2 1.5 0.6 10.8 0.1 4.9 4 2 3 7 7 7 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC47547.1 - 0.083 13.4 0.0 3.1 8.4 0.1 3.1 2 0 0 2 2 2 0 Ankyrin repeat zf-AN1 PF01428.16 EFC47548.1 - 0.072 13.3 7.6 0.17 12.1 7.6 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger FYVE PF01363.21 EFC47548.1 - 0.78 9.9 6.9 1.4 9.1 6.9 1.7 1 1 0 1 1 1 0 FYVE zinc finger Opy2 PF09463.10 EFC47548.1 - 1.9 8.9 5.9 4.1 7.8 5.9 1.6 1 0 0 1 1 1 0 Opy2 protein MRJP PF03022.16 EFC47549.1 - 0.0026 17.1 0.3 0.59 9.4 0.1 2.4 2 0 0 2 2 2 2 Major royal jelly protein Telomere_res PF16684.5 EFC47549.1 - 0.0071 15.9 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 2 Telomere resolvase SGL PF08450.12 EFC47549.1 - 0.086 12.4 0.0 22 4.5 0.0 3.0 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 EFC47550.1 - 2.2e-38 128.4 3.4 0.00012 22.0 0.1 12.8 12 0 0 12 12 12 7 NHL repeat GPS PF01825.21 EFC47550.1 - 5e-06 26.9 1.3 9e-06 26.1 0.1 2.2 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Phytase-like PF13449.6 EFC47550.1 - 9.3e-05 22.5 0.4 0.0048 16.9 0.0 3.3 4 0 0 4 4 4 1 Esterase-like activity of phytase EGF_2 PF07974.13 EFC47550.1 - 0.00057 20.2 6.4 0.0015 18.8 6.4 1.8 1 0 0 1 1 1 1 EGF-like domain ANAPC4_WD40 PF12894.7 EFC47550.1 - 0.0041 17.4 0.0 25 5.3 0.0 4.5 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUSP PF06337.12 EFC47551.1 - 0.099 13.3 2.0 0.45 11.2 2.0 2.2 1 0 0 1 1 1 0 DUSP domain DUF1218 PF06749.12 EFC47551.1 - 0.11 13.0 7.5 3.5 8.2 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) RabGAP-TBC PF00566.18 EFC47553.1 - 5e-26 91.7 9.9 1.7e-24 86.7 9.9 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Homeobox_KN PF05920.11 EFC47554.1 - 8.3e-11 41.6 0.2 2e-10 40.4 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC47554.1 - 2.3e-08 33.8 1.0 6.1e-08 32.4 1.0 1.8 1 0 0 1 1 1 1 Homeodomain CDC45 PF02724.14 EFC47554.1 - 4.2 5.5 18.3 5.8 5.1 18.3 1.2 1 0 0 1 1 1 0 CDC45-like protein RGS PF00615.19 EFC47555.1 - 1.4e-05 25.4 2.1 1.4e-05 25.4 2.1 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain Orf78 PF06024.12 EFC47555.1 - 2.8 8.3 7.5 2.9 8.2 2.9 2.9 3 1 0 3 3 3 0 Orf78 (ac78) Ribonuc_L-PSP PF01042.21 EFC47556.1 - 6.5e-27 94.0 1.1 7.1e-22 77.7 0.0 2.1 2 0 0 2 2 2 2 Endoribonuclease L-PSP PTPlike_phytase PF14566.6 EFC47556.1 - 0.0048 17.0 0.1 1.9 8.6 0.0 2.2 2 0 0 2 2 2 2 Inositol hexakisphosphate DASH_Ask1 PF08655.10 EFC47556.1 - 0.094 12.6 0.7 0.54 10.2 0.0 2.5 2 1 1 3 3 3 0 DASH complex subunit Ask1 NHL PF01436.21 EFC47557.1 - 7.4e-22 76.2 9.7 0.0014 18.5 0.1 5.9 5 0 0 5 5 5 5 NHL repeat BTB PF00651.31 EFC47557.1 - 3.4e-09 36.9 0.4 3.4e-09 36.9 0.4 2.4 3 0 0 3 3 3 1 BTB/POZ domain Linker_histone PF00538.19 EFC47557.1 - 4.2e-09 36.6 1.5 0.87 10.0 0.0 5.7 5 0 0 5 5 5 2 linker histone H1 and H5 family Plasmo_rep PF12135.8 EFC47557.1 - 0.0003 20.3 20.3 4.5 6.9 0.0 5.7 5 0 0 5 5 5 5 Plasmodium repeat family PCMT PF01135.19 EFC47557.1 - 0.38 10.5 2.1 14 5.4 0.0 3.8 5 0 0 5 5 5 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) BcrAD_BadFG PF01869.20 EFC47557.1 - 3.1 7.2 7.1 39 3.6 0.0 3.7 2 1 1 4 4 4 0 BadF/BadG/BcrA/BcrD ATPase family VPS9 PF02204.18 EFC47557.1 - 6.7 7.0 6.4 1.9 8.8 0.2 2.8 3 0 0 3 3 3 0 Vacuolar sorting protein 9 (VPS9) domain Hemerythrin PF01814.23 EFC47558.1 - 2.9e-05 24.7 0.1 5.4e-05 23.8 0.1 1.4 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF4419 PF14388.6 EFC47559.1 - 4.2e-101 338.3 0.1 5.3e-101 338.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) SH3_3 PF08239.11 EFC47559.1 - 0.23 11.8 4.8 0.29 11.4 0.0 2.7 3 0 0 3 3 3 0 Bacterial SH3 domain GET2 PF08690.10 EFC47560.1 - 0.41 10.3 2.8 0.7 9.5 2.8 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 CrgA PF06781.12 EFC47560.1 - 4 7.6 5.9 1.1 9.4 1.0 2.4 3 0 0 3 3 3 0 Cell division protein CrgA Ribosomal_S30 PF04758.14 EFC47561.1 - 1.2e-07 31.8 0.1 1.2e-07 31.8 0.1 2.7 2 1 1 3 3 3 1 Ribosomal protein S30 LRR_6 PF13516.6 EFC47562.1 - 3.6e-08 32.8 4.8 0.0011 18.8 0.1 5.3 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 EFC47562.1 - 6.3e-06 26.4 20.8 0.63 10.6 3.4 6.4 4 2 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47562.1 - 0.00016 21.4 9.0 0.31 10.8 0.0 4.7 3 1 1 4 4 4 2 Leucine rich repeat LRR_1 PF00560.33 EFC47562.1 - 0.73 10.6 5.8 40 5.3 0.0 6.2 6 0 0 6 6 6 0 Leucine Rich Repeat ELFV_dehydrog PF00208.21 EFC47563.1 - 8.6e-54 182.8 3.5 8.2e-51 173.1 0.1 2.7 2 1 1 3 3 3 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EFC47563.1 - 1.3e-39 135.1 0.0 2.1e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain AdoHcyase_NAD PF00670.21 EFC47563.1 - 0.0019 18.3 0.8 0.0059 16.7 0.2 2.1 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 EFC47563.1 - 0.017 14.4 0.0 0.033 13.6 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Bac_GDH PF05088.12 EFC47563.1 - 0.11 10.0 0.0 0.16 9.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial NAD-glutamate dehydrogenase NAD_binding_7 PF13241.6 EFC47563.1 - 0.17 12.3 0.2 0.5 10.8 0.1 1.9 2 1 0 2 2 2 0 Putative NAD(P)-binding PhoPQ_related PF10142.9 EFC47564.1 - 6.6e-87 291.5 1.5 1.5e-86 290.3 1.5 1.5 1 1 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DUF2341 PF10102.9 EFC47564.1 - 0.065 13.8 0.4 0.15 12.6 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2341) ASC PF00858.24 EFC47565.1 - 3.8e-12 45.9 19.5 7.3e-05 21.9 1.7 3.7 1 1 3 4 4 4 3 Amiloride-sensitive sodium channel Tho1_MOS11_C PF18592.1 EFC47566.1 - 0.0069 16.2 1.3 0.014 15.2 1.3 1.5 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain Ribosomal_S20p PF01649.18 EFC47566.1 - 0.3 11.8 2.4 2.1 9.1 2.4 2.2 1 1 0 1 1 1 0 Ribosomal protein S20 ADH_N_2 PF16884.5 EFC47567.1 - 9.7e-22 76.9 0.0 2.4e-21 75.6 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 EFC47567.1 - 2.7e-18 66.2 0.0 4.2e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 EFC47567.1 - 8.8e-10 39.8 0.0 1.6e-09 38.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NHL PF01436.21 EFC47568.1 - 1e-34 116.8 1.2 3e-06 27.0 0.0 6.8 6 0 0 6 6 6 6 NHL repeat BTB PF00651.31 EFC47568.1 - 4.8e-07 30.0 1.0 1e-06 28.9 0.1 2.1 2 0 0 2 2 2 1 BTB/POZ domain SGL PF08450.12 EFC47568.1 - 3.1e-06 26.9 0.1 0.98 8.9 0.0 4.1 3 1 3 6 6 6 3 SMP-30/Gluconolactonase/LRE-like region DUF2092 PF09865.9 EFC47568.1 - 0.00072 19.0 0.2 8.1 5.7 0.0 4.0 3 1 1 4 4 4 2 Predicted periplasmic protein (DUF2092) DUF1236 PF06823.12 EFC47568.1 - 0.0046 16.8 0.8 27 4.7 0.0 4.7 5 0 0 5 5 5 0 Protein of unknown function (DUF1236) B2-adapt-app_C PF09066.10 EFC47568.1 - 0.048 13.8 3.3 6.5 6.9 0.0 4.8 6 0 0 6 6 6 0 Beta2-adaptin appendage, C-terminal sub-domain Mur_ligase_C PF02875.21 EFC47568.1 - 0.051 13.8 0.0 28 5.1 0.0 4.0 2 1 1 3 3 3 0 Mur ligase family, glutamate ligase domain Phytase-like PF13449.6 EFC47568.1 - 0.068 13.1 0.1 72 3.2 0.0 4.0 3 1 0 3 3 3 0 Esterase-like activity of phytase ubiquitin PF00240.23 EFC47569.1 - 8.9e-135 438.7 21.3 3.6e-33 113.2 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 EFC47569.1 - 1.4e-65 217.0 21.5 7.2e-16 57.8 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC47569.1 - 2.8e-23 82.2 11.2 0.0003 21.2 0.2 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC47569.1 - 8.9e-17 60.8 5.0 0.016 15.1 0.1 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC47569.1 - 4.9e-16 58.9 9.2 0.014 15.8 0.1 4.1 1 1 3 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC47569.1 - 4.3e-15 55.8 3.8 0.07 13.2 0.0 5.1 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC47569.1 - 1.8e-13 51.0 1.4 0.27 11.8 0.0 4.2 1 1 2 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 EFC47569.1 - 1.2e-11 44.7 0.4 0.43 10.4 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 EFC47569.1 - 6.1e-09 35.8 25.1 5 7.2 0.2 8.0 8 0 0 8 8 8 4 Ubiquitin-like domain DUF3861 PF12977.7 EFC47569.1 - 1.8e-06 28.0 2.9 9.8 6.4 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) Methyltrans_RNA PF04452.14 EFC47569.1 - 1.9e-06 27.4 1.3 1.3 8.3 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase DUF2870 PF11069.8 EFC47569.1 - 4e-06 27.1 0.0 30 5.1 0.0 5.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) UDP-g_GGTase PF06427.11 EFC47569.1 - 1e-05 25.6 7.0 2.1 8.5 0.1 4.2 4 0 0 4 4 4 3 UDP-glucose:Glycoprotein Glucosyltransferase ACT_5 PF13710.6 EFC47569.1 - 4.8e-05 23.1 6.0 11 5.9 0.1 4.3 4 0 0 4 4 4 0 ACT domain RBD PF02196.15 EFC47569.1 - 5.6e-05 23.1 0.0 40 4.4 0.0 4.3 4 0 0 4 4 4 0 Raf-like Ras-binding domain YcgR_2 PF12945.7 EFC47569.1 - 0.00033 20.7 6.2 22 5.3 0.1 4.3 4 0 0 4 4 4 0 Flagellar protein YcgR DUF969 PF06149.12 EFC47569.1 - 0.0004 19.9 0.0 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) DUF1866 PF08952.11 EFC47569.1 - 0.00044 20.1 1.7 38 4.1 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1866) UN_NPL4 PF11543.8 EFC47569.1 - 0.00068 20.1 3.7 45 4.6 0.0 4.3 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 ProRS-C_2 PF09181.10 EFC47569.1 - 0.0013 18.8 10.5 16 5.7 0.1 4.2 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Big_7 PF17957.1 EFC47569.1 - 0.0019 18.9 0.1 1.4e+02 3.3 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain Tash_PEST PF07708.11 EFC47569.1 - 0.003 17.6 11.7 15 5.9 0.2 4.4 4 0 0 4 4 4 0 Tash protein PEST motif Raf1_HTH PF18579.1 EFC47569.1 - 0.0037 16.9 0.0 1e+02 2.7 0.0 4.2 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain ORF11CD3 PF10549.9 EFC47569.1 - 0.0039 17.3 0.0 91 3.3 0.0 4.7 4 0 0 4 4 4 0 ORF11CD3 domain ACT_4 PF13291.6 EFC47569.1 - 0.0068 17.0 1.5 1.4e+02 3.2 0.0 4.2 4 0 0 4 4 4 0 ACT domain Baculo_p48 PF04878.13 EFC47569.1 - 0.035 13.0 0.0 41 3.0 0.0 3.1 3 0 0 3 3 3 0 Baculovirus P48 protein DUF493 PF04359.14 EFC47569.1 - 0.049 14.2 0.1 2.9e+02 2.1 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF493) HAMP_N3 PF18575.1 EFC47569.1 - 0.17 11.5 8.5 54 3.5 0.1 4.2 4 0 0 4 4 4 0 HAMP N-terminal domain 3 PI3K_p85B PF02192.16 EFC47569.1 - 0.23 11.2 10.7 43 3.9 0.1 4.3 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain DMA PF03474.14 EFC47569.1 - 0.26 10.9 4.0 1e+02 2.6 0.0 4.1 4 0 0 4 4 4 0 DMRTA motif Phage_sheath_1N PF17481.2 EFC47569.1 - 0.31 11.5 8.9 2.4e+03 -0.9 8.9 4.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Myosin_N PF02736.19 EFC47569.1 - 0.53 10.2 7.7 1e+02 2.8 0.1 5.3 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain Coagulin PF02035.15 EFC47569.1 - 2.2 8.1 4.6 2.2e+02 1.6 0.0 3.8 4 0 0 4 4 4 0 Coagulin BTB PF00651.31 EFC47570.1 - 8.1e-27 93.6 3.7 3.4e-15 56.2 0.1 2.9 2 1 0 2 2 2 2 BTB/POZ domain RCC1_2 PF13540.6 EFC47570.1 - 5.7e-21 73.8 20.2 2.5e-06 27.1 1.2 5.2 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC47570.1 - 6.4e-12 45.9 17.1 0.00035 21.1 0.4 6.4 5 2 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RGS PF00615.19 EFC47570.1 - 0.0049 17.1 1.7 0.0049 17.1 1.7 3.6 3 1 0 3 3 3 1 Regulator of G protein signaling domain DED PF01335.21 EFC47570.1 - 1.9 8.8 8.8 0.043 14.1 0.7 2.6 3 0 0 3 3 3 0 Death effector domain DAGK_cat PF00781.24 EFC47571.1 - 5.4e-22 77.7 0.0 1.6e-21 76.2 0.0 1.9 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain CcmE PF03100.15 EFC47571.1 - 0.051 13.6 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 CcmE Bac_A_amyl_C PF18612.1 EFC47571.1 - 0.09 12.6 0.3 0.33 10.7 0.1 2.0 2 0 0 2 2 2 0 Bacterial Alpha amylase C-terminal domain Hira PF07569.11 EFC47572.1 - 3.4e-39 134.8 0.0 6.2e-39 134.0 0.0 1.5 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 EFC47572.1 - 4.8e-15 55.7 21.9 9.6e-06 26.3 1.5 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47572.1 - 1.5e-07 31.6 0.1 0.016 15.5 0.0 4.5 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC47572.1 - 3.9e-05 22.8 3.8 0.019 14.0 0.5 2.9 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 EFC47572.1 - 0.00097 19.0 1.5 1.2 9.2 0.0 3.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Big_3_5 PF16640.5 EFC47572.1 - 0.017 15.3 2.2 1.3 9.3 0.4 3.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) RRS1 PF04939.12 EFC47573.1 - 7.7e-44 149.4 0.8 7.7e-44 149.4 0.8 2.1 2 1 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) TPR_8 PF13181.6 EFC47574.1 - 1.5e-12 46.7 15.2 0.00043 20.3 0.2 7.0 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47574.1 - 1.5e-12 46.8 16.2 5.3e-05 22.9 0.5 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47574.1 - 8.7e-10 38.8 1.0 6.7e-06 26.3 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC47574.1 - 3.7e-08 33.0 0.4 0.38 10.7 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47574.1 - 2.9e-07 30.1 13.9 0.00047 20.1 0.4 6.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47574.1 - 1e-06 28.4 1.3 0.11 12.6 0.1 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47574.1 - 0.00033 21.2 0.0 0.58 10.9 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC47574.1 - 0.0023 18.0 0.0 0.007 16.5 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47574.1 - 0.0032 17.1 3.4 0.13 12.0 0.1 4.7 5 1 0 5 5 5 1 TPR repeat TPR_19 PF14559.6 EFC47574.1 - 0.0072 16.8 0.0 0.54 10.8 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC47574.1 - 0.04 14.5 3.2 4.4 8.2 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DegQ PF08181.11 EFC47574.1 - 0.057 13.5 1.2 6.2 7.0 0.1 3.3 2 0 0 2 2 2 0 DegQ (SacQ) family TPR_17 PF13431.6 EFC47574.1 - 0.11 13.0 0.5 26 5.5 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC47574.1 - 0.19 11.4 2.7 0.7 9.6 0.6 2.9 2 1 1 3 3 3 0 26S proteasome subunit RPN7 Ank_2 PF12796.7 EFC47575.1 - 5.6e-21 74.9 1.2 9e-08 32.6 0.0 4.2 2 2 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47575.1 - 5.2e-17 60.2 0.4 0.00059 20.1 0.0 6.6 8 0 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 EFC47575.1 - 7e-15 54.9 0.4 8.3e-07 29.2 0.0 5.9 3 2 3 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC47575.1 - 3.6e-14 52.9 1.5 0.00094 19.7 0.0 5.5 1 1 5 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 EFC47575.1 - 1.8e-11 43.9 0.0 0.0083 16.5 0.0 4.3 3 0 0 3 3 3 3 Ankyrin repeat U-box PF04564.15 EFC47575.1 - 2.1e-11 43.8 0.0 6.6e-11 42.2 0.0 1.8 1 0 0 1 1 1 1 U-box domain Matrilin_ccoil PF10393.9 EFC47575.1 - 0.24 11.3 1.7 4.5 7.2 0.0 2.9 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin NHL PF01436.21 EFC47576.1 - 3.1e-26 90.1 5.1 0.0015 18.5 0.0 9.8 10 0 0 10 10 10 6 NHL repeat SGL PF08450.12 EFC47576.1 - 0.0048 16.5 5.6 10 5.6 0.1 5.9 4 3 1 6 6 6 2 SMP-30/Gluconolactonase/LRE-like region Pirin PF02678.16 EFC47577.1 - 2.5e-29 101.4 0.3 5.5e-29 100.3 0.3 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 EFC47577.1 - 2.9e-25 88.6 0.1 3.2e-24 85.3 0.0 2.1 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 EFC47577.1 - 0.002 17.8 0.7 1.4 8.7 0.0 2.3 2 0 0 2 2 2 2 Cupin domain PseudoU_synth_2 PF00849.22 EFC47578.1 - 8.2e-19 68.3 1.6 1e-17 64.7 0.2 2.2 1 1 1 2 2 2 1 RNA pseudouridylate synthase NAD_binding_7 PF13241.6 EFC47578.1 - 0.087 13.3 0.1 0.25 11.8 0.1 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Cdc6_C PF09079.11 EFC47578.1 - 0.1 12.6 1.1 6.6 6.8 0.0 3.0 3 0 0 3 3 3 0 CDC6, C terminal winged helix domain RGS PF00615.19 EFC47579.1 - 7.2e-20 71.4 2.3 1.2e-19 70.7 2.3 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC47579.1 - 0.0008 19.2 0.2 0.0016 18.2 0.2 1.5 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain 7tm_3 PF00003.22 EFC47579.1 - 0.062 13.0 10.1 0.098 12.4 10.1 1.3 1 0 0 1 1 1 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF2070 PF09843.9 EFC47579.1 - 2.4 6.3 11.9 4.2 5.5 11.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SLAC1 PF03595.17 EFC47580.1 - 0.0083 15.4 0.5 0.0098 15.2 0.5 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel CT_C_D PF02682.16 EFC47580.1 - 0.091 12.5 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D Ras PF00071.22 EFC47581.1 - 3.6e-46 156.7 0.4 4.5e-46 156.4 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47581.1 - 1.9e-30 105.5 0.2 3.3e-30 104.8 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47581.1 - 3.5e-09 36.3 0.1 4.1e-09 36.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC47581.1 - 1.6e-06 27.8 0.2 1.3e-05 24.9 0.2 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC47581.1 - 1.8e-05 24.2 0.0 2.1e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC47581.1 - 8.6e-05 22.6 0.0 0.00017 21.6 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC47581.1 - 0.0074 16.2 0.2 1.1 9.2 0.2 2.4 2 1 1 3 3 3 1 RsgA GTPase TniB PF05621.11 EFC47581.1 - 0.028 13.8 0.0 0.043 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_14 PF13173.6 EFC47581.1 - 0.03 14.4 0.0 0.043 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFC47581.1 - 0.039 13.7 0.0 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 EFC47581.1 - 0.09 12.2 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFC47581.1 - 0.093 12.3 0.1 8.4 5.9 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B PH PF00169.29 EFC47582.1 - 8.6e-16 58.4 0.1 1e-15 58.1 0.1 1.1 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 EFC47582.1 - 1e-08 35.2 0.1 0.00039 20.5 0.0 2.1 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 EFC47582.1 - 0.0012 19.2 0.2 0.003 17.9 0.2 1.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EFC47582.1 - 0.041 14.3 0.0 0.046 14.1 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 EFC47582.1 - 0.049 14.0 0.0 0.085 13.2 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_13 PF16652.5 EFC47582.1 - 0.062 13.1 0.0 0.081 12.7 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Sec3-PIP2_bind PF15277.6 EFC47582.1 - 0.062 13.4 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH KCNQ2_u3 PF16642.5 EFC47583.1 - 1.1 10.3 3.8 3.6 8.6 3.2 2.0 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 tRNA_m1G_MT PF01746.21 EFC47584.1 - 4.1e-18 65.8 0.1 4.1e-18 65.8 0.1 1.9 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase PI3_PI4_kinase PF00454.27 EFC47585.1 - 8.2e-51 173.2 1.1 5.8e-36 124.6 0.1 2.5 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC47585.1 - 4.1e-42 143.7 3.3 8e-42 142.7 3.3 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EFC47585.1 - 0.0067 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PIP5K PF01504.18 EFC47586.1 - 7.8e-71 238.5 7.2 2.2e-70 237.0 7.2 1.7 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PRiA4_ORF3 PF07929.11 EFC47587.1 - 5.1e-10 39.3 1.4 5.1e-10 39.3 1.4 2.2 2 0 0 2 2 2 1 Plasmid pRiA4b ORF-3-like protein BCS1_N PF08740.11 EFC47587.1 - 0.028 14.4 0.0 0.065 13.2 0.0 1.6 1 0 0 1 1 1 0 BCS1 N terminal SPRY PF00622.28 EFC47589.1 - 8.4e-16 58.2 2.4 1.5e-15 57.4 2.4 1.4 1 0 0 1 1 1 1 SPRY domain BTB_2 PF02214.22 EFC47589.1 - 3.8e-13 49.6 0.0 8.6e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Neuralized PF07177.12 EFC47589.1 - 0.047 13.7 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Neuralized ATP13 PF12921.7 EFC47589.1 - 0.069 13.0 0.7 0.14 12.0 0.7 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase expression BolA PF01722.18 EFC47590.1 - 3.5e-30 104.1 1.8 4.4e-30 103.8 1.8 1.1 1 0 0 1 1 1 1 BolA-like protein DUF1981 PF09324.10 EFC47591.1 - 0.083 12.7 4.9 0.33 10.8 4.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1981) FKBP_N PF01346.18 EFC47591.1 - 0.31 12.0 4.9 0.45 11.5 4.3 1.6 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase CHIP_TPR_N PF18391.1 EFC47591.1 - 0.48 11.2 5.9 1.6 9.6 5.9 1.8 1 0 0 1 1 1 0 CHIP N-terminal tetratricopeptide repeat domain Cys_Met_Meta_PP PF01053.20 EFC47592.1 - 7.4e-45 153.1 0.0 9.5e-45 152.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 EFC47592.1 - 0.00025 20.3 0.0 0.00038 19.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II dCache_1 PF02743.18 EFC47593.1 - 0.00031 20.6 3.1 0.00071 19.4 3.1 1.6 1 0 0 1 1 1 1 Cache domain EPL1 PF10513.9 EFC47593.1 - 0.00098 19.5 0.1 0.0029 18.0 0.1 1.7 1 1 0 1 1 1 1 Enhancer of polycomb-like Guanylate_cyc PF00211.20 EFC47593.1 - 0.0012 18.5 2.1 0.019 14.6 0.2 2.9 2 1 0 3 3 3 1 Adenylate and Guanylate cyclase catalytic domain NucS PF01939.16 EFC47593.1 - 0.011 15.1 0.0 0.02 14.2 0.0 1.3 1 0 0 1 1 1 0 Endonuclease NucS TIP120 PF08623.10 EFC47593.1 - 0.93 9.2 3.6 0.66 9.7 0.7 2.2 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) DUF2701 PF10857.8 EFC47594.1 - 0.036 14.1 0.5 0.062 13.3 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) ubiquitin PF00240.23 EFC47595.1 - 1.9e-60 200.5 3.5 3.7e-30 103.5 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC47595.1 - 1.4e-29 101.7 4.3 7.3e-15 54.6 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFC47595.1 - 1e-07 32.1 0.2 0.00077 19.6 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC47595.1 - 2.6e-07 31.0 2.8 0.0023 18.3 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC47595.1 - 6.1e-06 26.5 1.8 0.0076 16.6 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC47595.1 - 7.2e-06 25.9 0.1 0.012 15.5 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC47595.1 - 8.1e-06 25.8 3.9 0.14 12.2 0.1 3.9 3 1 1 4 4 4 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC47595.1 - 9.2e-06 26.2 0.1 0.0077 16.8 0.0 2.2 2 0 0 2 2 2 2 DUF2407 ubiquitin-like domain TUG-UBL1 PF11470.8 EFC47595.1 - 0.0092 16.2 0.0 1 9.6 0.0 2.2 2 0 0 2 2 2 1 TUG ubiquitin-like domain bPH_3 PF14470.6 EFC47595.1 - 0.067 13.6 0.8 0.57 10.6 0.3 2.4 2 1 0 2 2 2 0 Bacterial PH domain ProRS-C_2 PF09181.10 EFC47595.1 - 0.13 12.5 0.5 11 6.3 0.0 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_p85B PF02192.16 EFC47595.1 - 0.18 11.6 0.3 8.3 6.2 0.0 2.4 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain PI3K_rbd PF00794.18 EFC47595.1 - 0.23 11.6 0.9 6 7.1 0.2 2.4 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain MMR_HSR1_C PF08438.10 EFC47596.1 - 7.9e-30 103.7 0.1 1.3e-29 103.0 0.1 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 EFC47596.1 - 3.2e-21 75.5 0.0 7.8e-21 74.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC47596.1 - 5.7e-07 29.2 0.0 3e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC47596.1 - 0.0017 18.4 0.1 0.0073 16.4 0.0 2.0 2 0 0 2 2 2 1 Dynamin family ATP_bind_1 PF03029.17 EFC47596.1 - 0.0098 15.7 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 EFC47596.1 - 0.021 15.4 0.1 0.059 13.9 0.0 1.8 2 0 0 2 2 2 0 ABC transporter AAA_18 PF13238.6 EFC47596.1 - 0.022 15.3 0.6 0.58 10.7 0.0 2.8 2 1 1 3 3 3 0 AAA domain AAA_28 PF13521.6 EFC47596.1 - 0.029 14.6 0.2 0.18 12.0 0.0 2.2 2 1 1 3 3 3 0 AAA domain GTP_EFTU PF00009.27 EFC47596.1 - 0.048 13.2 0.1 5.6 6.4 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 EFC47596.1 - 0.055 13.5 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_29 PF13555.6 EFC47596.1 - 0.11 12.3 0.3 0.31 10.8 0.3 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain LRR_4 PF12799.7 EFC47597.1 - 2.9e-11 43.4 16.0 4.5e-05 23.7 1.6 4.8 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC47597.1 - 1.2e-10 40.5 18.0 0.056 13.5 0.2 7.0 8 0 0 8 8 8 4 Leucine Rich repeat LRR_1 PF00560.33 EFC47597.1 - 0.0012 19.1 16.5 4.6 8.2 0.1 7.4 9 0 0 9 9 9 2 Leucine Rich Repeat LRR_8 PF13855.6 EFC47597.1 - 0.0089 15.8 16.7 0.18 11.6 3.1 5.4 2 1 3 5 5 5 3 Leucine rich repeat YdiH PF15930.5 EFC47597.1 - 0.035 14.3 0.1 5.8 7.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function F-box-like PF12937.7 EFC47597.1 - 0.085 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 F-box-like RGS PF00615.19 EFC47598.1 - 3.5e-06 27.3 1.9 6.1e-06 26.5 0.9 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF354 PF04007.12 EFC47598.1 - 0.0068 15.5 0.2 0.017 14.2 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF354) ABC_membrane PF00664.23 EFC47599.1 - 1.2e-49 169.5 19.6 1.6e-49 169.0 19.6 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC47599.1 - 3.9e-36 124.6 0.0 9.6e-36 123.3 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC47599.1 - 9.2e-07 28.5 0.5 0.0003 20.3 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFC47599.1 - 0.00053 20.3 0.4 0.0065 16.7 0.2 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC47599.1 - 0.00098 19.5 0.3 0.0049 17.3 0.3 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC47599.1 - 0.0016 18.1 0.1 0.0041 16.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 EFC47599.1 - 0.005 16.8 0.1 0.29 11.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 EFC47599.1 - 0.01 15.5 0.0 0.044 13.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 EFC47599.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_ATPase PF09818.9 EFC47599.1 - 0.015 14.1 0.0 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_21 PF13304.6 EFC47599.1 - 0.033 14.0 0.0 0.34 10.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 EFC47599.1 - 0.037 13.9 0.0 0.082 12.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase DUF87 PF01935.17 EFC47599.1 - 0.043 13.9 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain Zeta_toxin PF06414.12 EFC47599.1 - 0.046 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 EFC47599.1 - 0.054 13.9 0.0 9.4 6.7 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFC47599.1 - 0.06 13.9 0.0 0.15 12.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFC47599.1 - 0.093 12.4 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 EFC47599.1 - 0.14 11.3 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Mito_carr PF00153.27 EFC47600.1 - 8.9e-45 150.6 4.6 1.5e-16 60.1 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein LapA_dom PF06305.11 EFC47600.1 - 0.22 11.3 2.0 2.1 8.2 0.0 3.1 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Peptidase_C2 PF00648.21 EFC47601.1 - 6.2e-88 294.6 0.0 8.9e-88 294.1 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 EFC47601.1 - 5.3e-37 127.2 3.4 3.2e-12 46.9 0.1 3.7 4 1 0 4 4 4 3 Calpain large subunit, domain III Herpes_glycop_D PF01537.17 EFC47601.1 - 0.11 12.6 0.0 0.41 10.8 0.0 1.9 2 0 0 2 2 2 0 Herpesvirus glycoprotein D/GG/GX domain Cys_Met_Meta_PP PF01053.20 EFC47602.1 - 5.7e-146 485.9 0.0 6.4e-146 485.8 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 EFC47602.1 - 0.00087 17.9 0.0 0.0013 17.4 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.21 EFC47602.1 - 0.011 14.9 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II Glutaredoxin PF00462.24 EFC47602.1 - 0.012 15.8 0.0 0.062 13.5 0.0 2.2 2 0 0 2 2 2 0 Glutaredoxin DSPc PF00782.20 EFC47604.1 - 6e-29 100.5 0.0 6.7e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC47604.1 - 0.00034 20.8 0.0 0.00057 20.0 0.0 1.4 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 EFC47604.1 - 0.0063 16.1 0.0 0.0072 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFC47604.1 - 0.045 14.0 0.0 0.084 13.2 0.0 1.4 1 1 0 1 1 1 0 Rit1 DUSP-like domain Transpos_assoc PF13963.6 EFC47604.1 - 0.1 12.9 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Transposase-associated domain Ras PF00071.22 EFC47605.1 - 4.8e-36 123.8 0.1 5.5e-36 123.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47605.1 - 1.3e-13 51.2 0.0 2.1e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC47605.1 - 4.4e-07 29.5 0.1 5.4e-07 29.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC47605.1 - 6.9e-05 22.5 0.1 0.00018 21.1 0.1 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC47605.1 - 0.0012 18.9 0.0 0.0018 18.3 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC47605.1 - 0.0067 15.8 0.1 0.0069 15.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Pkinase_Tyr PF07714.17 EFC47606.1 - 7e-54 182.8 0.0 5.7e-53 179.8 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 EFC47606.1 - 2.2e-52 178.1 0.0 3.9e-52 177.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC47606.1 - 8.2e-06 24.8 0.0 1.2e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC47606.1 - 3e-05 23.5 0.0 4.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC47606.1 - 0.013 14.8 0.0 0.019 14.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 EFC47606.1 - 0.036 14.0 0.0 0.05 13.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC47606.1 - 0.044 12.7 0.0 0.082 11.8 0.0 1.6 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 EFC47606.1 - 0.054 13.1 0.3 9.7 5.7 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 D123 PF07065.14 EFC47607.1 - 1.3e-16 60.6 6.1 1.3e-16 60.6 6.1 2.6 2 2 0 2 2 2 2 D123 Laminin_G_3 PF13385.6 EFC47608.1 - 1.2e-16 61.2 3.1 2e-16 60.5 3.1 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily EGF_2 PF07974.13 EFC47608.1 - 0.00044 20.5 8.1 0.00044 20.5 8.1 2.7 3 0 0 3 3 3 1 EGF-like domain Laminin_EGF PF00053.24 EFC47608.1 - 5.9 7.1 17.7 0.47 10.6 3.5 2.8 2 0 0 2 2 2 0 Laminin EGF domain Peptidase_M28 PF04389.17 EFC47609.1 - 9.8e-16 58.0 0.0 1.6e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 RRT14 PF17075.5 EFC47609.1 - 0.015 15.4 1.8 0.028 14.5 1.8 1.3 1 0 0 1 1 1 0 Regular of rDNA transcription protein 14 AbiGi PF10899.8 EFC47609.1 - 0.026 14.4 0.2 0.059 13.2 0.2 1.6 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin LRR_2 PF07723.13 EFC47610.1 - 0.01 16.4 3.0 1.3 9.9 0.0 3.8 3 0 0 3 3 3 0 Leucine Rich Repeat TcA_TcB_BD PF18276.1 EFC47610.1 - 0.033 13.3 0.1 0.36 9.9 0.0 2.2 2 0 0 2 2 2 0 Tc toxin complex TcA C-terminal TcB-binding domain Mob1_phocein PF03637.17 EFC47610.1 - 0.064 13.3 0.6 0.12 12.3 0.6 1.4 1 0 0 1 1 1 0 Mob1/phocein family LRR_1 PF00560.33 EFC47610.1 - 0.17 12.5 11.2 8 7.4 2.4 5.6 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 EFC47610.1 - 0.48 10.9 0.0 0.48 10.9 0.0 5.6 4 2 2 6 6 6 0 Leucine Rich repeats (2 copies) VWA PF00092.28 EFC47613.1 - 1.5e-21 77.4 1.2 2e-21 77.0 1.2 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC47613.1 - 4.7e-19 68.8 0.0 6.1e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC47613.1 - 1.4e-13 51.5 0.4 4e-13 50.0 0.1 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC47613.1 - 3.6e-06 26.5 0.0 5.3e-06 26.0 0.0 1.1 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein PP2C_2 PF13672.6 EFC47613.1 - 0.014 15.1 0.1 0.2 11.3 0.0 2.0 1 1 1 2 2 2 0 Protein phosphatase 2C DUF2201 PF09967.9 EFC47613.1 - 0.023 14.9 0.2 0.056 13.6 0.0 1.8 2 0 0 2 2 2 0 VWA-like domain (DUF2201) DUF444 PF04285.12 EFC47613.1 - 0.057 12.5 0.1 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF444) Zip PF02535.22 EFC47614.1 - 5.5e-22 78.4 18.2 1.3e-21 77.2 18.2 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter TcpS PF17456.2 EFC47615.1 - 0.029 14.4 1.1 0.034 14.2 1.1 1.3 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S Ammonium_transp PF00909.21 EFC47616.1 - 2.4e-51 174.7 39.0 6.2e-51 173.3 37.7 2.1 1 1 1 2 2 2 1 Ammonium Transporter Family FeoB_C PF07664.12 EFC47616.1 - 0.51 10.1 4.9 7 6.4 0.1 3.8 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus TssO PF17561.2 EFC47616.1 - 3.4 7.8 7.8 0.22 11.6 0.3 2.7 3 0 0 3 3 3 0 Type VI secretion system, TssO TPR_1 PF00515.28 EFC47617.1 - 1.9e-16 59.1 26.5 0.00031 20.4 0.5 9.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47617.1 - 6.2e-14 50.9 23.4 0.014 15.5 0.2 9.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47617.1 - 4.9e-13 49.2 0.3 0.032 14.5 0.0 7.2 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47617.1 - 2.1e-10 40.0 32.1 0.029 14.6 0.3 10.8 11 0 0 11 11 11 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC47617.1 - 6.1e-10 39.2 20.0 5.1e-07 29.8 1.1 5.0 5 0 0 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFC47617.1 - 6.6e-09 35.8 10.3 2.4 9.0 0.1 9.9 10 1 1 11 11 10 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47617.1 - 3.4e-07 30.7 0.0 0.37 11.3 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47617.1 - 8.8e-05 23.1 0.0 0.36 11.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47617.1 - 0.00015 21.6 11.1 1.4 9.1 0.3 7.4 10 0 0 10 10 9 1 Tetratricopeptide repeat Sel1 PF08238.12 EFC47617.1 - 0.0027 18.3 12.0 0.45 11.3 0.0 6.2 7 0 0 7 7 6 2 Sel1 repeat TPR_11 PF13414.6 EFC47617.1 - 0.0089 15.7 0.0 0.0089 15.7 0.0 4.4 5 1 1 6 6 6 1 TPR repeat SRP_TPR_like PF17004.5 EFC47617.1 - 0.056 13.5 17.0 0.019 15.0 2.7 4.5 4 0 0 4 4 4 0 Putative TPR-like repeat TPR_17 PF13431.6 EFC47617.1 - 0.41 11.1 3.5 26 5.5 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC47617.1 - 2.6 8.1 8.7 1.4 9.0 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Zn_clus PF00172.18 EFC47618.1 - 6.3e-07 29.4 7.7 1.1e-06 28.7 7.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain V-ATPase_C PF03223.15 EFC47618.1 - 0.071 12.5 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 V-ATPase subunit C DUF5521 PF17659.1 EFC47618.1 - 5.5 4.7 7.0 11 3.7 7.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5521) IL13 PF03487.13 EFC47619.1 - 0.3 10.9 1.4 0.42 10.4 0.2 1.9 2 0 0 2 2 2 0 Interleukin-13 Cullin PF00888.22 EFC47620.1 - 1.2e-80 272.0 37.3 3.2e-71 240.8 25.3 2.1 1 1 1 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 EFC47620.1 - 8.3e-25 86.6 1.6 2.6e-24 85.0 1.6 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.22 EFC47621.1 - 2e-174 581.7 30.6 2e-174 581.7 30.6 1.3 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 EFC47621.1 - 4.3e-25 87.5 1.7 4.3e-25 87.5 1.7 3.9 3 0 0 3 3 3 1 Cullin protein neddylation domain Q_salvage PF10343.9 EFC47622.1 - 1.2e-86 290.8 0.4 1.2e-86 290.8 0.4 1.3 2 0 0 2 2 2 1 Potential Queuosine, Q, salvage protein family DUF1688 PF07958.11 EFC47622.1 - 0.0066 15.2 0.2 2.3 6.9 0.0 2.2 1 1 0 2 2 2 2 Protein of unknown function (DUF1688) EIF_2_alpha PF07541.12 EFC47622.1 - 0.036 14.2 0.2 1.4 9.1 0.1 2.7 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit Pkinase PF00069.25 EFC47623.1 - 3.1e-53 180.8 0.1 3.8e-53 180.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47623.1 - 6.2e-20 71.6 0.0 1e-18 67.6 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 EFC47623.1 - 0.0031 17.1 0.5 0.0049 16.5 0.5 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFC47623.1 - 0.0073 16.2 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Nif11 PF07862.11 EFC47623.1 - 0.015 15.6 0.1 0.042 14.2 0.1 1.7 1 0 0 1 1 1 0 Nif11 domain Kdo PF06293.14 EFC47623.1 - 0.028 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Med20 PF08612.11 EFC47625.1 - 4.9e-10 39.2 0.1 7.2e-10 38.6 0.1 1.3 1 1 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex AAA_25 PF13481.6 EFC47626.1 - 8.8e-22 77.6 0.0 1.4e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 EFC47626.1 - 1.3e-15 57.4 0.0 2.1e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 EFC47626.1 - 7.5e-09 36.0 0.0 1.4e-07 31.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 EFC47626.1 - 2.1e-07 30.5 0.1 3.7e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 KaiC Toprim_4 PF13662.6 EFC47626.1 - 4.4e-06 27.1 0.0 1.5e-05 25.3 0.0 2.0 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 EFC47626.1 - 8.9e-06 26.0 0.0 2.8e-05 24.5 0.0 2.0 1 0 0 1 1 1 1 Toprim-like AAA_16 PF13191.6 EFC47626.1 - 0.0024 18.3 0.0 0.0062 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 EFC47626.1 - 0.0024 17.2 0.0 0.0055 16.0 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 EFC47626.1 - 0.0064 17.0 0.5 0.11 13.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter Toprim_3 PF13362.6 EFC47626.1 - 0.0064 16.8 0.0 0.11 12.9 0.0 2.4 2 0 0 2 2 2 1 Toprim domain ResIII PF04851.15 EFC47626.1 - 0.0089 16.0 6.6 1.1 9.3 0.0 3.4 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit PLDc_3 PF13918.6 EFC47626.1 - 0.012 15.3 0.1 0.022 14.4 0.1 1.4 1 0 0 1 1 1 0 PLD-like domain T2SSE PF00437.20 EFC47626.1 - 0.022 13.8 0.0 0.052 12.6 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Lar_restr_allev PF14354.6 EFC47626.1 - 0.035 14.5 0.2 0.035 14.5 0.2 2.4 2 0 0 2 2 2 0 Restriction alleviation protein Lar zf-CHC2 PF01807.20 EFC47626.1 - 0.065 13.1 0.2 0.065 13.1 0.2 2.8 3 0 0 3 3 2 0 CHC2 zinc finger AAA_29 PF13555.6 EFC47626.1 - 0.067 12.9 1.4 0.28 11.0 0.2 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EFC47626.1 - 0.069 13.4 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 EFC47626.1 - 0.076 13.6 0.1 5.4 7.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF763 PF05559.11 EFC47626.1 - 0.15 11.3 0.6 0.34 10.1 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF763) DUF913 PF06025.12 EFC47626.1 - 0.16 10.9 4.9 0.28 10.1 4.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Viral_helicase1 PF01443.18 EFC47626.1 - 0.48 10.1 7.3 42 3.8 0.0 3.5 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 EFC47626.1 - 2.2 8.7 15.4 0.075 13.5 3.4 3.4 2 1 1 3 3 3 0 AAA domain Zn_Tnp_IS1595 PF12760.7 EFC47626.1 - 2.7 8.1 10.5 0.19 11.7 0.2 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Tn7_Tnp_TnsA_C PF08721.11 EFC47626.1 - 6.6 7.5 6.5 22 5.8 0.1 4.1 4 0 0 4 4 3 0 TnsA endonuclease C terminal Rieske PF00355.26 EFC47627.1 - 2.8e-13 49.6 0.1 7.4e-13 48.3 0.1 1.7 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 EFC47627.1 - 8.8e-06 26.1 0.9 2.1e-05 24.9 0.0 2.1 2 1 1 3 3 3 1 Ubiquinol cytochrome reductase transmembrane region Methyltransf_16 PF10294.9 EFC47628.1 - 1.2e-20 73.9 3.2 7.1e-19 68.2 3.2 2.1 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 EFC47628.1 - 0.0021 17.6 0.0 0.0037 16.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ras PF00071.22 EFC47629.1 - 3.2e-27 95.1 0.0 6.5e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47629.1 - 1.9e-10 41.0 0.0 4.3e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC47629.1 - 0.0022 17.8 0.7 0.0052 16.6 0.7 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC47629.1 - 0.045 13.7 0.5 0.1 12.5 0.5 1.6 1 0 0 1 1 1 0 F-box-like ER PF01133.17 EFC47629.1 - 0.17 12.0 5.4 0.095 12.7 2.9 1.9 2 0 0 2 2 2 0 Enhancer of rudimentary Rax2 PF12768.7 EFC47630.1 - 0.0056 16.2 1.3 0.0097 15.4 0.1 2.1 2 0 0 2 2 2 1 Cortical protein marker for cell polarity Stevor PF17410.2 EFC47630.1 - 0.052 13.1 0.2 0.11 12.0 0.2 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame ECSCR PF15820.5 EFC47630.1 - 0.14 12.0 2.1 0.36 10.7 2.1 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF4448 PF14610.6 EFC47630.1 - 0.14 11.9 1.8 8 6.2 0.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF4448) CRAL_TRIO PF00650.20 EFC47631.1 - 1.5e-28 99.6 0.3 2e-28 99.1 0.3 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC47631.1 - 9.9e-05 22.5 0.5 0.00032 20.8 0.5 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF4132 PF13569.6 EFC47631.1 - 0.038 13.8 0.6 3.4 7.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4132) Latarcin PF10279.9 EFC47631.1 - 1 9.8 5.6 1.3 9.5 0.1 2.9 3 0 0 3 3 3 0 Latarcin precursor UPF0126 PF03458.13 EFC47633.1 - 0.0003 20.6 1.4 0.23 11.3 0.7 2.7 2 0 0 2 2 2 2 UPF0126 domain ASC PF00858.24 EFC47634.1 - 4.7e-14 52.2 22.3 7.3e-05 21.9 5.2 4.8 2 2 3 5 5 5 4 Amiloride-sensitive sodium channel Barstar PF01337.18 EFC47634.1 - 0.19 11.8 1.2 13 5.9 0.0 2.5 2 0 0 2 2 2 0 Barstar (barnase inhibitor) RCC1_2 PF13540.6 EFC47635.1 - 3.1e-32 109.7 31.3 4.4e-09 35.9 0.5 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC47635.1 - 3.9e-26 91.4 12.2 4e-08 33.7 0.3 7.6 7 2 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat DUF5022 PF16425.5 EFC47635.1 - 0.017 14.6 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5022) Tachylectin PF14517.6 EFC47635.1 - 0.019 14.5 0.5 0.11 12.0 0.2 2.3 1 1 1 2 2 2 0 Tachylectin Exo_endo_phos PF03372.23 EFC47636.1 - 0.0098 15.4 0.1 0.0098 15.4 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ank_2 PF12796.7 EFC47638.1 - 2.3e-14 53.7 0.1 6.2e-07 29.9 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC47638.1 - 2.3e-10 39.8 1.5 0.002 18.5 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 EFC47638.1 - 1.4e-09 38.0 0.3 0.0047 17.2 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC47638.1 - 1.9e-09 37.5 0.4 0.014 15.9 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 EFC47638.1 - 4e-07 30.4 2.1 0.0027 18.2 0.1 3.6 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Hydrolase_3 PF08282.12 EFC47639.1 - 0.055 13.2 0.2 1 9.0 0.0 2.5 1 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase DUF3452 PF11934.8 EFC47640.1 - 0.029 13.9 1.0 0.057 13.0 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3452) Pkinase PF00069.25 EFC47641.1 - 8.2e-52 176.2 1.6 1.3e-51 175.5 1.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47641.1 - 1.9e-49 168.3 1.5 1.7e-47 161.9 1.5 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC47641.1 - 3.4e-06 26.1 0.2 5.1e-06 25.5 0.2 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC47641.1 - 0.00084 18.4 0.7 0.00084 18.4 0.7 2.0 2 1 0 2 2 2 1 Haspin like kinase domain TMEMspv1-c74-12 PF11044.8 EFC47641.1 - 0.0078 16.2 0.6 0.02 14.9 0.6 1.7 1 0 0 1 1 1 1 Plectrovirus spv1-c74 ORF 12 transmembrane protein APH PF01636.23 EFC47641.1 - 0.29 11.0 0.0 0.72 9.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Chlam_PMP PF02415.17 EFC47641.1 - 1.1 9.9 18.8 1.1 9.9 0.1 5.4 5 0 0 5 5 5 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pkinase PF00069.25 EFC47642.1 - 1.7e-47 162.0 0.0 3.5e-47 161.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47642.1 - 8.6e-47 159.6 0.0 1.7e-42 145.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC47642.1 - 0.0055 15.7 0.3 0.052 12.5 0.0 2.2 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 EFC47642.1 - 0.21 11.5 0.0 0.34 10.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DNA_ligase_aden PF01653.18 EFC47643.1 - 0.05 12.7 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain Filo_VP24 PF06389.11 EFC47643.1 - 0.07 12.6 0.3 0.14 11.7 0.3 1.4 1 0 0 1 1 1 0 Filovirus membrane-associated protein VP24 Pkinase PF00069.25 EFC47644.1 - 2.8e-22 79.3 2.3 8.6e-22 77.7 0.9 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47644.1 - 4.1e-09 36.1 0.0 6.8e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Peptidase_M42 PF05343.14 EFC47645.1 - 5.7e-10 38.7 0.1 0.0041 16.2 0.0 3.3 3 0 0 3 3 3 3 M42 glutamyl aminopeptidase Peptidase_M20 PF01546.28 EFC47645.1 - 3.3e-09 36.7 0.0 6.5e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 EFC47645.1 - 0.046 13.4 0.3 2.4 7.8 0.0 2.8 3 0 0 3 3 3 0 Peptidase family M28 DUF3993 PF13158.6 EFC47645.1 - 0.082 13.1 0.4 0.21 11.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) Pkinase PF00069.25 EFC47646.1 - 8.1e-11 41.8 0.9 2.4e-10 40.2 0.6 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47646.1 - 3.9e-09 36.2 1.6 0.00059 19.2 0.1 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase RWP-RK PF02042.15 EFC47647.1 - 4.4e-19 68.2 0.3 8.1e-19 67.3 0.3 1.5 1 0 0 1 1 1 1 RWP-RK domain Lambda_CIII PF02061.16 EFC47647.1 - 0.06 13.4 0.4 0.16 12.1 0.4 1.6 1 0 0 1 1 1 0 Lambda Phage CIII HTH_23 PF13384.6 EFC47647.1 - 0.11 12.4 0.1 0.46 10.4 0.0 2.0 1 1 1 2 2 2 0 Homeodomain-like domain VIT1 PF01988.19 EFC47648.1 - 0.12 12.2 0.8 0.18 11.6 0.3 1.5 2 0 0 2 2 2 0 VIT family PrgI PF12666.7 EFC47648.1 - 1.8 9.3 6.7 1.9 9.2 3.7 2.1 2 0 0 2 2 2 0 PrgI family protein RAP PF08373.10 EFC47648.1 - 4.1 7.6 5.5 0.99 9.6 0.5 2.6 3 1 0 3 3 3 0 RAP domain Asp PF00026.23 EFC47649.1 - 3.3e-40 138.4 2.0 4e-40 138.2 2.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 EFC47649.1 - 3.8e-05 24.0 1.3 0.046 13.9 0.1 2.2 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 EFC47649.1 - 0.018 14.8 0.0 0.042 13.6 0.0 1.8 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal DUF4116 PF13475.6 EFC47650.1 - 6.6e-49 163.4 18.6 1.3e-08 34.4 0.2 5.9 2 2 5 7 7 7 7 Domain of unknown function (DUF4116) Rsbr_N PF08678.10 EFC47650.1 - 0.036 14.1 0.0 0.25 11.4 0.0 2.3 2 1 1 3 3 3 0 Rsbr N terminal APG6_N PF17675.1 EFC47652.1 - 0.04 14.4 0.3 0.04 14.4 0.3 3.9 3 1 2 5 5 5 0 Apg6 coiled-coil region CAP_N PF01213.19 EFC47652.1 - 0.048 13.2 1.5 0.1 12.1 1.5 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal DUF1318 PF07027.12 EFC47652.1 - 0.1 13.1 1.2 0.32 11.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1318) DUF948 PF06103.11 EFC47652.1 - 1.6 9.1 8.9 0.72 10.1 0.3 4.0 3 3 1 4 4 4 0 Bacterial protein of unknown function (DUF948) NPV_P10 PF05531.12 EFC47652.1 - 4.2 7.9 6.5 2 8.9 0.1 3.2 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein PIN_8 PF18476.1 EFC47652.1 - 7.1 6.4 11.2 14 5.5 5.1 2.8 1 1 1 3 3 3 0 PIN like domain NACHT_N PF17100.5 EFC47652.1 - 9.2 6.0 11.5 0.27 11.1 2.8 2.6 3 0 0 3 3 3 0 N-terminal domain of NWD NACHT-NTPase MAP70 PF07058.11 EFC47653.1 - 4.2 6.0 10.7 5.9 5.5 7.9 1.9 2 0 0 2 2 2 0 Microtubule-associated protein 70 Thioredoxin PF00085.20 EFC47654.1 - 7.7e-25 86.9 0.0 1.1e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFC47654.1 - 6.4e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFC47654.1 - 0.00033 21.1 0.2 0.0014 19.0 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 EFC47654.1 - 0.0019 18.0 0.0 0.0024 17.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Phosducin PF02114.16 EFC47654.1 - 0.0072 15.3 0.0 0.0087 15.0 0.0 1.1 1 0 0 1 1 1 1 Phosducin AhpC-TSA PF00578.21 EFC47654.1 - 0.014 15.3 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family DIM1 PF02966.16 EFC47654.1 - 0.039 13.7 0.0 0.051 13.4 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 Redoxin PF08534.10 EFC47654.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Redoxin dCache_1 PF02743.18 EFC47655.1 - 0.011 15.5 1.1 0.022 14.6 1.1 1.6 1 0 0 1 1 1 0 Cache domain PPR_3 PF13812.6 EFC47655.1 - 0.029 14.5 0.1 0.084 13.0 0.1 1.8 1 0 0 1 1 1 0 Pentatricopeptide repeat domain DUF3624 PF12292.8 EFC47655.1 - 0.25 11.8 0.4 0.65 10.5 0.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3624) Roc PF08477.13 EFC47656.1 - 0.00067 19.9 0.2 0.0034 17.6 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC47656.1 - 0.0016 18.1 0.1 0.0031 17.1 0.1 1.5 1 0 0 1 1 1 1 Ras family potato_inhibit PF00280.18 EFC47656.1 - 0.17 12.6 0.0 0.44 11.2 0.0 1.6 1 0 0 1 1 1 0 Potato inhibitor I family Ank_3 PF13606.6 EFC47657.1 - 5e-07 29.5 0.4 0.46 11.2 0.0 4.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 EFC47657.1 - 1.6e-06 28.6 0.5 0.0002 21.9 0.1 3.9 2 2 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC47657.1 - 0.00043 20.8 1.2 0.11 13.1 0.2 3.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC47657.1 - 0.045 14.2 0.2 9.2 6.9 0.0 3.8 3 0 0 3 3 3 0 Ankyrin repeat NHL PF01436.21 EFC47658.1 - 4.1e-30 102.3 0.0 0.00048 20.0 0.0 10.0 9 0 0 9 9 9 8 NHL repeat EGF_2 PF07974.13 EFC47658.1 - 5.4e-14 52.3 85.2 0.00059 20.2 10.0 5.5 5 0 0 5 5 5 5 EGF-like domain EGF PF00008.27 EFC47658.1 - 0.19 12.1 54.8 0.089 13.1 3.9 6.0 5 0 0 5 5 5 0 EGF-like domain MapZ_C2 PF18708.1 EFC47658.1 - 2.8 8.3 6.2 48 4.3 0.2 3.8 3 1 1 4 4 4 0 MapZ extracellular C-terminal domain 2 Guanylate_cyc PF00211.20 EFC47659.1 - 1e-52 178.4 0.2 2e-52 177.5 0.2 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC47659.1 - 6.1e-15 55.4 0.1 2e-14 53.7 0.1 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC47659.1 - 7.8e-08 32.3 0.0 8.3e-07 29.0 0.0 2.4 2 0 0 2 2 2 1 PAS fold Allexi_40kDa PF05549.11 EFC47659.1 - 0.01 15.3 1.1 2.7 7.4 0.0 2.9 3 0 0 3 3 3 0 Allexivirus 40kDa protein HNOBA PF07701.14 EFC47659.1 - 0.1 12.0 0.2 0.22 11.0 0.2 1.5 1 0 0 1 1 1 0 Heme NO binding associated DASH_Dad1 PF08649.10 EFC47659.1 - 0.15 12.2 1.2 0.75 10.0 0.0 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad1 Ank_2 PF12796.7 EFC47660.1 - 0.0012 19.4 0.0 0.0087 16.6 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC47660.1 - 0.0076 16.8 0.0 0.018 15.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC47660.1 - 0.029 14.7 0.1 0.097 13.0 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Macoilin PF09726.9 EFC47660.1 - 0.033 12.8 7.9 0.042 12.4 7.9 1.2 1 0 0 1 1 1 0 Macoilin family ABC2_membrane_3 PF12698.7 EFC47660.1 - 0.14 11.2 10.1 0.2 10.7 10.1 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein BES1_N PF05687.13 EFC47660.1 - 0.38 11.1 6.0 0.61 10.5 6.0 1.3 1 0 0 1 1 1 0 BES1/BZR1 plant transcription factor, N-terminal Peptidase_M20 PF01546.28 EFC47661.1 - 4.4e-28 98.4 0.0 6.3e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC47661.1 - 5e-09 36.0 0.1 1.8e-08 34.3 0.1 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 EFC47661.1 - 5.6e-08 32.7 0.0 5.8e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase family M28 hSac2 PF12456.8 EFC47662.1 - 1e-06 28.5 0.4 3.1e-06 26.9 0.1 2.1 2 0 0 2 2 2 1 Inositol phosphatase Myosin_TH1 PF06017.13 EFC47662.1 - 3e-05 23.8 0.5 7.2e-05 22.5 0.5 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding DUF5340 PF17275.2 EFC47662.1 - 0.027 14.6 1.2 14 5.9 0.0 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5340) OmpH PF03938.14 EFC47662.1 - 0.042 14.2 0.2 0.042 14.2 0.2 2.6 4 0 0 4 4 4 0 Outer membrane protein (OmpH-like) DUF2043 PF09740.9 EFC47662.1 - 2.3 8.9 8.3 0.27 11.9 0.5 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2043) Histone PF00125.24 EFC47663.1 - 2.4e-35 121.8 0.2 2.6e-35 121.7 0.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFC47663.1 - 2.1e-05 24.7 0.0 4.2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 EFC47663.1 - 4.2e-05 23.6 0.1 7.2e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFC47663.1 - 0.0009 19.6 0.0 0.0014 19.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 EFC47663.1 - 0.12 12.5 0.1 0.23 11.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit TPR_1 PF00515.28 EFC47664.1 - 0.037 13.8 0.2 0.076 12.9 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47664.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47665.1 - 0.0018 18.5 1.8 4.5 7.6 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat Condensin2nSMC PF12422.8 EFC47665.1 - 7.9 6.7 10.2 1.2 9.3 0.3 3.4 3 0 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit DNA_topoisoIV PF00521.20 EFC47666.1 - 3.3e-113 378.8 0.6 3.3e-113 378.8 0.6 2.0 2 1 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFC47666.1 - 1.7e-41 141.5 2.5 1.7e-41 141.5 2.5 3.1 3 0 0 3 3 3 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFC47666.1 - 1.5e-24 86.4 2.5 5.7e-24 84.5 2.5 2.0 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EFC47666.1 - 8.4e-12 45.6 0.3 3.2e-11 43.7 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EFC47666.1 - 6.5e-08 32.7 0.0 3.6e-07 30.3 0.0 2.3 2 0 0 2 2 2 1 Toprim domain CdhC PF03598.15 EFC47667.1 - 0.13 12.1 0.1 0.43 10.4 0.0 1.9 2 0 0 2 2 2 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit Sel1 PF08238.12 EFC47669.1 - 2.7e-05 24.7 10.8 1 10.1 0.4 4.7 4 1 0 4 4 4 3 Sel1 repeat CS PF04969.16 EFC47669.1 - 0.00057 20.8 0.5 0.01 16.8 0.2 3.0 3 0 0 3 3 3 1 CS domain SAS4 PF15460.6 EFC47669.1 - 0.0045 17.1 7.3 0.0067 16.5 5.4 2.4 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 TOM20_plant PF06552.12 EFC47669.1 - 0.0095 15.7 1.3 0.42 10.3 0.4 2.8 2 0 0 2 2 2 1 Plant specific mitochondrial import receptor subunit TOM20 LRS4 PF10422.9 EFC47669.1 - 0.022 14.3 6.2 0.069 12.7 6.2 1.9 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 DUF5082 PF16888.5 EFC47669.1 - 0.31 11.3 6.0 0.31 11.3 4.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) SOGA PF11365.8 EFC47669.1 - 4.5 8.5 15.3 0.96 10.6 2.3 3.2 2 1 1 3 3 3 0 Protein SOGA DivIC PF04977.15 EFC47669.1 - 6.5 6.6 7.7 3 7.7 2.2 2.8 1 1 1 2 2 2 0 Septum formation initiator Histone PF00125.24 EFC47670.1 - 8.9e-20 71.4 0.2 8.9e-20 71.4 0.2 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 EFC47670.1 - 2.9e-10 39.7 0.3 2.9e-10 39.7 0.3 2.0 2 0 0 2 2 2 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 EFC47670.1 - 0.0019 18.5 0.0 0.0055 17.0 0.0 1.8 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RCC1_2 PF13540.6 EFC47671.1 - 1.9e-21 75.3 6.7 1.4e-08 34.3 0.2 4.0 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC47671.1 - 1.3e-15 57.8 0.2 0.00096 19.7 0.0 4.4 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat LRR_6 PF13516.6 EFC47672.1 - 1.7e-22 77.5 16.1 0.0008 19.3 0.0 8.1 8 0 0 8 8 8 5 Leucine Rich repeat LRR_8 PF13855.6 EFC47672.1 - 9.8e-22 76.5 18.6 1.3e-09 37.6 7.4 3.7 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC47672.1 - 8.2e-17 61.1 26.3 7.1e-05 23.1 0.1 5.2 2 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC47672.1 - 6.9e-07 28.9 4.6 0.00028 20.5 1.9 2.4 1 1 1 2 2 2 2 Leucine-rich repeat LRR_1 PF00560.33 EFC47672.1 - 1.5e-06 28.0 14.3 4.5 8.2 0.3 7.4 8 0 0 8 8 8 1 Leucine Rich Repeat DUF4747 PF15931.5 EFC47672.1 - 0.022 14.4 1.5 0.049 13.3 1.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4747) DUF3161 PF11362.8 EFC47672.1 - 0.14 12.1 3.2 1.4 8.9 0.1 3.1 3 1 0 4 4 4 0 Protein of unknown function (DUF3161) RNA_pol_I_TF PF04090.12 EFC47672.1 - 0.37 10.3 4.0 2.6 7.5 0.2 2.8 1 1 1 2 2 2 0 RNA polymerase I specific initiation factor Epimerase_2 PF02350.19 EFC47675.1 - 1.3e-88 297.2 0.1 1.9e-88 296.7 0.1 1.2 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase DUF4862 PF16154.5 EFC47675.1 - 0.024 14.0 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4862) Glycos_transf_N PF04413.16 EFC47675.1 - 0.027 14.1 0.0 0.11 12.1 0.0 2.0 1 1 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) YrhK PF14145.6 EFC47676.1 - 3.1e-18 65.4 24.9 1.5e-10 40.8 0.6 3.8 3 1 0 3 3 3 3 YrhK-like protein FtsH_ext PF06480.15 EFC47676.1 - 0.16 12.3 0.3 0.32 11.4 0.0 1.7 2 1 0 2 2 2 0 FtsH Extracellular DUF3978 PF13123.6 EFC47677.1 - 0.0098 15.6 0.0 0.016 14.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3978) Myf5 PF12232.8 EFC47677.1 - 0.013 16.2 1.1 2.9 8.7 0.1 2.6 2 0 0 2 2 2 0 Myogenic determination factor 5 StbA PF06406.11 EFC47679.1 - 0.029 13.6 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 StbA protein CHB_HEX PF03173.13 EFC47679.1 - 0.031 13.9 1.4 0.053 13.2 0.1 2.0 2 1 1 3 3 3 0 Putative carbohydrate binding domain FTCD_N PF07837.12 EFC47679.1 - 0.046 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Formiminotransferase domain, N-terminal subdomain PilM_2 PF11104.8 EFC47679.1 - 0.053 12.6 0.1 0.09 11.8 0.1 1.3 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; PI3K_rbd PF00794.18 EFC47679.1 - 0.064 13.4 1.4 0.48 10.6 0.1 2.9 3 0 0 3 3 3 0 PI3-kinase family, ras-binding domain VWA_2 PF13519.6 EFC47680.1 - 2.7e-13 50.5 0.0 7.2e-13 49.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC47680.1 - 4.6e-10 40.0 0.0 9.4e-10 39.0 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain Med25_VWA PF11265.8 EFC47680.1 - 0.00012 21.9 0.0 0.00043 20.2 0.0 1.9 2 1 0 2 2 2 1 Mediator complex subunit 25 von Willebrand factor type A TssR PF17643.1 EFC47680.1 - 0.00052 18.1 0.0 0.0009 17.3 0.0 1.3 1 0 0 1 1 1 1 Type VI secretion system, TssR VWA_3 PF13768.6 EFC47680.1 - 0.026 14.4 0.0 0.092 12.7 0.0 1.9 1 1 0 1 1 1 0 von Willebrand factor type A domain Rax2 PF12768.7 EFC47680.1 - 0.045 13.2 0.6 0.075 12.5 0.6 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF3140 PF11338.8 EFC47680.1 - 0.41 11.1 2.3 2.6 8.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) RNB PF00773.19 EFC47681.1 - 4.3e-90 302.4 5.7 1.3e-88 297.5 0.0 2.3 2 0 0 2 2 2 2 RNB domain OB_Dis3 PF17849.1 EFC47681.1 - 3.4e-20 71.9 0.0 1.1e-19 70.3 0.0 2.0 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 EFC47681.1 - 3.8e-08 33.4 0.3 0.0044 17.2 0.0 3.5 3 0 0 3 3 3 2 Cold shock domain Rrp44_CSD1 PF17216.3 EFC47681.1 - 1.6e-06 27.9 0.0 4.3e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 EFC47681.1 - 0.074 13.0 0.1 0.21 11.6 0.1 1.8 1 0 0 1 1 1 0 S1 domain HECT PF00632.25 EFC47682.1 - 4.8e-67 226.6 0.5 2.5e-66 224.2 0.1 2.5 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) ZZ PF00569.17 EFC47682.1 - 7e-14 51.4 36.1 1.2e-08 34.6 8.2 3.8 3 1 0 3 3 3 2 Zinc finger, ZZ type SPRY PF00622.28 EFC47682.1 - 9e-13 48.4 0.4 3.4e-12 46.5 0.4 2.0 1 0 0 1 1 1 1 SPRY domain zf-UBR PF02207.20 EFC47682.1 - 1e-07 32.0 15.1 1e-07 32.0 15.1 4.3 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) UBA PF00627.31 EFC47682.1 - 0.0018 18.1 0.1 0.0044 16.9 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain C1_2 PF03107.16 EFC47682.1 - 0.031 14.6 36.8 0.028 14.7 5.3 3.9 3 0 0 3 3 3 0 C1 domain LacAB_rpiB PF02502.18 EFC47683.1 - 4.6e-54 182.2 0.3 5.2e-54 182.0 0.3 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase Gly_rich_SFCGS PF14272.6 EFC47683.1 - 0.083 12.9 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Glycine-rich SFCGS PhoPQ_related PF10142.9 EFC47684.1 - 7.9e-93 311.0 0.6 9.4e-93 310.8 0.6 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein CdAMP_rec PF06153.11 EFC47684.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Cyclic-di-AMP receptor DUF924 PF06041.11 EFC47685.1 - 6.2e-54 182.9 2.5 1.3e-53 181.8 2.5 1.6 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) NUDIX PF00293.28 EFC47685.1 - 1.7e-12 47.5 0.5 1.2e-11 44.7 0.0 2.5 2 1 1 3 3 3 1 NUDIX domain FGGY_N PF00370.21 EFC47686.1 - 1.6e-68 230.9 0.2 2.5e-68 230.3 0.2 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 EFC47686.1 - 1.1e-61 208.1 0.3 1.9e-61 207.2 0.3 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain BcrAD_BadFG PF01869.20 EFC47686.1 - 0.0044 16.5 0.0 0.21 11.1 0.0 2.2 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family ABC_membrane PF00664.23 EFC47687.1 - 1.3e-41 143.0 17.2 1.9e-41 142.5 17.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC47687.1 - 2.5e-32 112.3 0.0 5.5e-32 111.1 0.0 1.6 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC47687.1 - 1.5e-06 27.8 2.1 0.00025 20.6 0.1 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC47687.1 - 0.00063 19.4 1.3 0.00082 19.1 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC47687.1 - 0.0015 19.0 0.4 0.0079 16.6 0.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFC47687.1 - 0.0029 18.0 0.2 0.46 10.9 0.1 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFC47687.1 - 0.0032 17.4 0.0 0.0098 15.8 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 EFC47687.1 - 0.0083 16.0 0.0 1.1 9.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 EFC47687.1 - 0.011 15.5 0.1 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC47687.1 - 0.012 15.9 0.1 0.21 11.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 EFC47687.1 - 0.019 14.7 0.1 0.046 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain ABC_ATPase PF09818.9 EFC47687.1 - 0.023 13.5 0.1 0.067 12.0 0.0 1.7 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_7 PF12775.7 EFC47687.1 - 0.04 13.4 0.0 0.082 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 EFC47687.1 - 0.062 13.8 0.0 0.2 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EFC47687.1 - 0.074 12.2 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit AAA_5 PF07728.14 EFC47687.1 - 0.082 12.9 0.1 0.32 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 EFC47687.1 - 0.098 11.9 0.0 0.54 9.5 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 EFC47687.1 - 0.13 12.8 0.1 0.34 11.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 EFC47687.1 - 0.14 11.7 0.0 1 8.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain TMEM151 PF14857.6 EFC47688.1 - 1.2e-13 50.8 9.1 1.6e-13 50.4 9.1 1.1 1 0 0 1 1 1 1 TMEM151 family Clathrin_lg_ch PF01086.17 EFC47689.1 - 5.2e-11 43.0 43.9 1e-08 35.6 27.2 3.0 1 1 1 2 2 2 2 Clathrin light chain Glyco_hydro_67N PF03648.14 EFC47689.1 - 0.72 10.1 5.0 0.16 12.2 0.7 2.1 2 1 0 2 2 2 0 Glycosyl hydrolase family 67 N-terminus WT1 PF02165.15 EFC47689.1 - 2.5 7.3 4.3 3.7 6.7 4.3 1.1 1 0 0 1 1 1 0 Wilm's tumour protein Pkinase PF00069.25 EFC47690.1 - 1.7e-76 257.1 0.1 3.6e-76 256.0 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47690.1 - 4.1e-40 137.7 0.0 7.9e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC47690.1 - 9.5e-09 35.0 0.0 3.2e-08 33.2 0.0 1.9 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EFC47690.1 - 0.0019 17.6 0.1 0.0041 16.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC47690.1 - 0.0029 17.5 0.1 0.021 14.7 0.2 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC47690.1 - 0.033 13.8 0.0 0.084 12.4 0.0 1.7 1 0 0 1 1 1 0 Choline/ethanolamine kinase NatB_MDM20 PF09797.9 EFC47691.1 - 1.9e-80 270.7 17.1 3.2e-80 269.9 17.1 1.4 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit DUF3219 PF11514.8 EFC47691.1 - 0.01 15.8 3.8 0.68 10.0 0.1 4.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3219) ApoA-II PF04711.13 EFC47691.1 - 0.027 14.6 0.0 6.4 7.0 0.0 3.3 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) TPR_14 PF13428.6 EFC47691.1 - 0.038 14.8 1.0 38 5.5 0.1 4.6 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47691.1 - 0.26 11.8 11.0 9.6 6.8 0.0 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Corona_NSP4_C PF16348.5 EFC47691.1 - 0.27 12.1 1.9 1.3 9.9 1.4 2.5 2 0 0 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus TPR_6 PF13174.6 EFC47691.1 - 4.8 8.0 5.0 18 6.3 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat BLOC1_2 PF10046.9 EFC47691.1 - 4.8 7.6 12.2 1.8 8.9 2.5 3.9 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 XhlA PF10779.9 EFC47691.1 - 6.7 7.0 9.4 0.23 11.7 1.8 2.6 3 0 0 3 3 3 0 Haemolysin XhlA Myosin_head PF00063.21 EFC47692.1 - 3.5e-199 663.4 11.4 5.6e-199 662.7 11.4 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFC47692.1 - 8.7e-35 120.1 2.3 1.5e-34 119.3 2.3 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 EFC47692.1 - 2.4e-08 33.5 0.0 5.4e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFC47692.1 - 4.4e-08 32.9 0.1 1e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFC47692.1 - 0.0004 20.0 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain CdiI_4 PF18624.1 EFC47692.1 - 0.46 11.0 6.7 0.33 11.4 1.6 3.3 3 0 0 3 3 3 0 CDI immunity protein EGF_2 PF07974.13 EFC47693.1 - 6.6e-12 45.6 96.5 0.0011 19.2 7.7 6.3 6 0 0 6 6 6 5 EGF-like domain EGF PF00008.27 EFC47693.1 - 0.00017 21.8 3.2 0.00017 21.8 3.2 6.1 6 0 0 6 6 6 2 EGF-like domain EGF_Tenascin PF18720.1 EFC47693.1 - 0.0053 16.8 9.3 0.0053 16.8 9.3 6.5 6 1 0 6 6 6 2 Tenascin EGF domain TRP PF06011.12 EFC47693.1 - 0.74 8.5 15.0 1.8 7.2 5.7 2.7 2 1 1 3 3 3 0 Transient receptor potential (TRP) ion channel Laminin_EGF PF00053.24 EFC47693.1 - 5.8 7.1 81.1 0.13 12.4 10.1 5.9 3 1 3 6 6 6 0 Laminin EGF domain CNOT11 PF10155.9 EFC47694.1 - 7e-37 126.4 5.9 1.6e-36 125.2 5.9 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Adaptin_binding PF10199.9 EFC47695.1 - 2.1e-14 54.2 8.8 4.3e-14 53.2 8.8 1.6 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Foie-gras_1 PF11817.8 EFC47696.1 - 1e-28 100.6 4.8 2.6e-28 99.3 4.8 1.6 1 1 0 1 1 1 1 Foie gras liver health family 1 Gryzun-like PF12742.7 EFC47696.1 - 6.5e-09 35.7 0.5 2e-08 34.1 0.5 1.9 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking DUF4116 PF13475.6 EFC47697.1 - 2e-51 171.5 15.7 2.1e-15 56.2 0.1 5.9 3 1 5 8 8 8 6 Domain of unknown function (DUF4116) Flavi_NS4A PF01350.17 EFC47697.1 - 0.14 12.1 0.0 9.4 6.2 0.0 2.1 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4A PFK PF00365.20 EFC47701.1 - 3.9e-55 187.2 0.0 5.9e-55 186.6 0.0 1.3 1 0 0 1 1 1 1 Phosphofructokinase DAGK_cat PF00781.24 EFC47701.1 - 0.0069 16.0 0.0 0.032 13.8 0.0 2.1 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain Ribosomal_S5 PF00333.20 EFC47701.1 - 0.047 13.7 0.1 2.3 8.2 0.1 2.5 2 0 0 2 2 2 0 Ribosomal protein S5, N-terminal domain DIRP PF06584.13 EFC47702.1 - 4.8e-12 46.0 0.2 4.8e-12 46.0 0.2 3.5 2 1 1 3 3 3 1 DIRP DUF3450 PF11932.8 EFC47702.1 - 7.9e-05 22.1 12.6 7.9e-05 22.1 12.6 3.8 3 1 1 4 4 4 2 Protein of unknown function (DUF3450) Myb_DNA-bind_7 PF15963.5 EFC47702.1 - 0.00015 21.6 0.3 0.0037 17.1 0.1 3.4 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EFC47702.1 - 0.00025 21.2 0.0 0.00056 20.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain NPV_P10 PF05531.12 EFC47702.1 - 0.16 12.5 6.4 2.6 8.6 0.1 4.3 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Pkinase PF00069.25 EFC47703.1 - 7e-78 261.6 0.0 8.4e-78 261.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47703.1 - 2.2e-38 132.0 0.0 2.9e-38 131.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC47703.1 - 1.7e-07 30.9 0.0 3.1e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EFC47703.1 - 0.012 15.2 0.3 0.4 10.3 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFC47703.1 - 0.066 13.1 0.1 0.23 11.4 0.1 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC47703.1 - 0.066 12.1 0.6 0.093 11.7 0.6 1.2 1 0 0 1 1 1 0 Haspin like kinase domain OppC_N PF12911.7 EFC47704.1 - 0.036 14.0 0.1 0.076 13.0 0.1 1.5 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF3899 PF13038.6 EFC47704.1 - 0.053 14.0 5.5 2 9.0 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) GTP-bdg_M PF16360.5 EFC47704.1 - 0.07 13.7 0.6 0.15 12.7 0.6 1.5 1 0 0 1 1 1 0 GTP-binding GTPase Middle Region Pox_EPC_I2-L1 PF12575.8 EFC47704.1 - 0.12 12.6 0.1 0.59 10.4 0.1 2.2 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 CoA_trans PF01144.23 EFC47705.1 - 5.3e-119 395.4 0.1 6e-75 251.4 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase ATP-synt_ab PF00006.25 EFC47706.1 - 3.2e-60 203.4 0.0 4.5e-60 202.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFC47706.1 - 1.8e-13 50.8 0.0 5.1e-13 49.3 0.0 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 EFC47706.1 - 5.8e-05 23.5 0.1 0.023 15.1 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC47706.1 - 0.014 15.8 0.2 0.048 14.0 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 EFC47706.1 - 0.037 12.9 0.2 0.075 11.9 0.2 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 EFC47706.1 - 0.04 14.3 0.4 0.81 10.1 0.1 2.7 2 1 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 EFC47706.1 - 0.065 13.6 1.1 0.31 11.4 0.4 2.1 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 EFC47706.1 - 0.42 9.7 3.1 0.22 10.7 0.3 1.9 3 0 0 3 3 3 0 NB-ARC domain ATPase PF06745.13 EFC47706.1 - 1 8.7 3.2 0.73 9.1 1.3 1.8 2 0 0 2 2 2 0 KaiC WD40 PF00400.32 EFC47707.1 - 3.8e-12 46.5 1.0 0.00067 20.4 0.1 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47707.1 - 5.2e-05 23.5 0.0 0.16 12.2 0.0 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 EFC47707.1 - 0.0078 16.1 1.5 0.33 11.0 0.0 3.5 5 0 0 5 5 5 1 PQQ enzyme repeat Prefoldin_2 PF01920.20 EFC47708.1 - 4.9e-16 58.6 0.0 6.2e-16 58.3 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit SHE3 PF17078.5 EFC47708.1 - 0.0093 15.7 0.2 0.011 15.5 0.2 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 PAP_central PF04928.17 EFC47708.1 - 0.043 12.8 0.1 0.048 12.6 0.1 1.0 1 0 0 1 1 1 0 Poly(A) polymerase central domain Ribonuc_red_sm PF00268.21 EFC47709.1 - 1.6e-117 392.0 4.2 2e-117 391.7 4.2 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Haem_oxygenas_2 PF14518.6 EFC47709.1 - 0.12 12.1 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Iron-containing redox enzyme Ribosomal_L13e PF01294.18 EFC47710.1 - 3.8e-61 206.1 8.3 4.8e-61 205.7 8.3 1.1 1 0 0 1 1 1 1 Ribosomal protein L13e DUF4116 PF13475.6 EFC47711.1 - 8.3e-171 553.7 77.3 5.3e-15 54.9 0.6 22.0 14 6 8 23 23 23 22 Domain of unknown function (DUF4116) DUF1667 PF07892.11 EFC47711.1 - 0.12 12.5 0.0 1.3e+02 2.7 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1667) ThylakoidFormat PF11264.8 EFC47711.1 - 0.17 11.6 5.1 0.15 11.7 1.2 2.7 3 0 0 3 3 3 0 Thylakoid formation protein RMI1_N PF08585.12 EFC47713.1 - 1.5e-49 168.7 0.9 1.8e-49 168.5 0.0 1.5 2 0 0 2 2 2 1 RecQ mediated genome instability protein MRP-L27 PF09809.9 EFC47713.1 - 0.052 13.4 0.0 0.18 11.6 0.0 1.9 1 1 1 2 2 2 0 Mitochondrial ribosomal protein L27 LRR_6 PF13516.6 EFC47714.1 - 1.5e-05 24.7 24.1 3.1 8.1 0.0 8.9 10 0 0 10 10 10 4 Leucine Rich repeat LRR_4 PF12799.7 EFC47714.1 - 3.3e-05 24.2 17.4 0.016 15.6 0.4 5.6 5 2 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47714.1 - 0.0043 16.8 13.0 0.025 14.4 0.5 4.1 5 0 0 5 5 5 2 Leucine rich repeat DUF4200 PF13863.6 EFC47715.1 - 2.6e-20 73.0 21.6 2.6e-20 73.0 21.6 3.8 4 1 0 4 4 4 1 Domain of unknown function (DUF4200) Clathrin PF00637.20 EFC47716.1 - 1.5e-174 572.8 55.5 1.1e-30 106.4 1.3 8.9 7 1 2 9 9 9 8 Region in Clathrin and VPS Clathrin_H_link PF13838.6 EFC47716.1 - 1e-19 70.2 1.3 1e-19 70.2 1.3 3.4 4 0 0 4 4 4 1 Clathrin-H-link Clathrin_propel PF01394.20 EFC47716.1 - 1.5e-18 66.1 5.1 1.2e-05 25.3 0.0 6.3 7 0 0 7 7 7 3 Clathrin propeller repeat Clathrin-link PF09268.10 EFC47716.1 - 1.3e-05 24.5 0.0 6.6e-05 22.2 0.0 2.4 2 0 0 2 2 2 1 Clathrin, heavy-chain linker NFRKB_winged PF14465.6 EFC47716.1 - 0.37 11.0 2.9 1.3 9.2 0.1 3.0 2 0 0 2 2 2 0 NFRKB Winged Helix-like TPR_8 PF13181.6 EFC47716.1 - 1.2 9.5 6.6 51 4.4 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat ASH PF15780.5 EFC47717.1 - 7.9e-67 221.6 77.6 0.00011 22.4 0.1 30.6 31 0 0 31 31 31 18 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 EFC47717.1 - 1.5e-22 79.6 6.5 0.0046 17.1 0.0 13.7 16 0 0 16 16 16 5 Flagellar-associated PapD-like MYCBPAP PF14646.6 EFC47717.1 - 9.8e-16 57.7 29.6 0.00098 18.2 5.9 11.8 12 1 2 14 14 14 7 MYCBP-associated protein family DUF1573 PF07610.11 EFC47717.1 - 1.6e-15 56.9 72.5 0.033 14.2 0.0 23.6 25 2 0 26 26 26 7 Protein of unknown function (DUF1573) Motile_Sperm PF00635.26 EFC47717.1 - 5.8e-13 48.7 85.1 0.12 12.3 0.0 20.2 23 1 0 23 23 23 8 MSP (Major sperm protein) domain TMEM131_like PF12371.8 EFC47717.1 - 4.4e-09 36.5 39.1 0.12 12.7 0.1 15.5 20 0 0 20 20 20 3 Transmembrane protein 131-like DUF5001 PF16392.5 EFC47717.1 - 0.00062 19.6 25.0 0.094 12.6 0.0 10.4 11 0 0 11 11 11 2 Ig-like domain Big_2 PF02368.18 EFC47717.1 - 0.044 13.7 4.0 9.5 6.2 0.1 4.8 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 2) A2M_BRD PF07703.14 EFC47717.1 - 3.2 8.1 8.1 51 4.2 0.0 6.3 7 0 0 7 7 7 0 Alpha-2-macroglobulin bait region domain Zn_protease PF05618.11 EFC47719.1 - 2e-14 53.6 0.0 3.7e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Putative ATP-dependant zinc protease DUF3098 PF11297.8 EFC47719.1 - 0.016 14.8 0.7 0.036 13.7 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) DUF2407_C PF13373.6 EFC47719.1 - 0.22 11.7 2.4 0.81 9.9 2.4 2.0 1 1 0 1 1 1 0 DUF2407 C-terminal domain Sec20 PF03908.13 EFC47719.1 - 1.7 8.6 6.8 2.2 8.2 4.7 2.3 2 1 0 2 2 2 0 Sec20 Tmemb_9 PF05434.11 EFC47719.1 - 3.8 7.4 13.3 0.024 14.5 2.1 2.5 1 1 2 3 3 3 0 TMEM9 DUF896 PF05979.12 EFC47720.1 - 0.021 14.7 3.0 0.033 14.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) GDPD PF03009.17 EFC47721.1 - 1e-35 123.7 0.0 1.7e-35 123.0 0.0 1.4 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 EFC47721.1 - 0.059 13.9 0.0 0.13 12.8 0.0 1.6 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family ATP-synt_ab PF00006.25 EFC47722.1 - 2e-68 230.3 0.0 2.7e-68 229.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 EFC47722.1 - 2.2e-13 50.5 1.8 4e-13 49.7 1.8 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain SPA PF08616.10 EFC47723.1 - 1.6e-11 44.2 0.9 2.3e-10 40.4 0.0 2.7 3 0 0 3 3 3 1 Stabilization of polarity axis Afi1 PF07792.12 EFC47723.1 - 0.0023 18.4 0.0 0.0023 18.4 0.0 3.0 4 0 0 4 4 4 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Myc_N PF01056.18 EFC47723.1 - 0.041 13.8 3.6 0.11 12.4 2.8 2.1 1 1 0 1 1 1 0 Myc amino-terminal region SPT6_acidic PF14632.6 EFC47723.1 - 2.9 8.6 7.5 0.5 11.0 1.6 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 DUF4837 PF16125.5 EFC47725.1 - 0.019 14.0 0.2 3.1 6.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4837) SRA1 PF07304.11 EFC47725.1 - 0.021 14.6 0.1 0.03 14.1 0.1 1.3 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) MSA-2c PF12238.8 EFC47725.1 - 7 6.6 6.4 1.5 8.8 0.2 2.4 1 1 2 3 3 3 0 Merozoite surface antigen 2c DUF1133 PF06576.11 EFC47726.1 - 0.074 12.4 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) PSK PF06404.12 EFC47726.1 - 0.75 10.8 3.3 0.32 12.0 0.5 1.7 2 0 0 2 2 2 0 Phytosulfokine precursor protein (PSK) Adaptin_N PF01602.20 EFC47727.1 - 6.1e-108 361.6 15.3 8.2e-108 361.2 15.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 EFC47727.1 - 7.2e-12 45.6 1.0 1.1e-11 45.0 0.1 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain HEAT PF02985.22 EFC47727.1 - 4.8e-06 26.4 2.5 2.8 8.4 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 EFC47727.1 - 0.0011 19.0 12.2 0.1 12.6 0.8 4.4 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC47727.1 - 0.0013 19.1 3.7 1.1 9.7 0.0 4.5 4 1 1 5 5 5 1 HEAT repeats AP3B1_C PF14796.6 EFC47727.1 - 0.019 15.2 3.9 0.034 14.4 2.2 2.3 1 1 1 2 2 2 0 Clathrin-adaptor complex-3 beta-1 subunit C-terminal TIP120 PF08623.10 EFC47727.1 - 0.095 12.5 6.3 1 9.1 0.1 4.2 3 1 1 4 4 4 0 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 EFC47727.1 - 0.25 11.9 1.2 71 4.1 0.0 4.6 5 0 0 5 5 5 0 HEAT-like repeat Ist1 PF03398.14 EFC47728.1 - 1.5e-60 203.8 4.1 1.9e-60 203.5 4.1 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway p450 PF00067.22 EFC47729.1 - 6.2e-16 58.2 0.2 7.3e-16 58.0 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 VAPB_antitox PF02697.14 EFC47729.1 - 0.0056 17.4 2.7 0.42 11.4 0.3 2.5 1 1 1 2 2 2 2 Putative antitoxin Mannosyl_trans4 PF15971.5 EFC47729.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 DolP-mannose mannosyltransferase Peptidase_C26 PF07722.13 EFC47729.1 - 0.15 11.8 0.1 0.38 10.5 0.1 1.6 1 1 1 2 2 2 0 Peptidase C26 RCC1 PF00415.18 EFC47730.1 - 3.6e-15 56.3 0.0 5.8e-08 33.2 0.0 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC47730.1 - 2.3e-11 43.2 8.0 2.6e-06 27.1 1.0 2.7 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat LRR_6 PF13516.6 EFC47731.1 - 0.00083 19.2 10.6 1.1 9.4 0.0 5.8 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 EFC47731.1 - 0.11 13.0 22.0 2.6 8.6 0.2 6.7 3 3 5 8 8 8 0 Leucine Rich repeats (2 copies) RPN2_C PF18004.1 EFC47734.1 - 1.5e-34 119.2 2.0 2.6e-34 118.5 2.0 1.4 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 EFC47734.1 - 4.4e-31 105.7 20.3 2.3e-06 27.8 0.3 8.4 8 0 0 8 8 8 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 EFC47734.1 - 2.9e-21 75.7 1.4 8.5e-14 51.7 0.1 5.0 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 EFC47734.1 - 0.013 15.7 0.3 0.88 10.0 0.1 4.0 4 0 0 4 4 4 0 HEAT repeat Clathrin_H_link PF13838.6 EFC47734.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 Clathrin-H-link TLD PF07534.16 EFC47735.1 - 8e-08 32.6 2.0 1.4e-07 31.8 2.0 1.5 1 1 0 1 1 1 1 TLD GYF PF02213.16 EFC47736.1 - 0.0001 21.9 0.9 0.00021 20.9 0.2 1.9 2 0 0 2 2 2 1 GYF domain GYF_2 PF14237.6 EFC47736.1 - 0.021 14.6 0.2 0.047 13.5 0.2 1.6 1 0 0 1 1 1 0 GYF domain 2 Arm PF00514.23 EFC47737.1 - 5e-13 48.6 3.7 0.0016 18.4 0.1 6.8 7 1 0 7 7 7 2 Armadillo/beta-catenin-like repeat PCI PF01399.27 EFC47737.1 - 0.75 10.3 4.4 0.79 10.3 1.1 2.7 2 0 0 2 2 2 0 PCI domain BTB PF00651.31 EFC47738.1 - 1.2e-06 28.7 1.4 0.01 16.1 0.1 3.9 4 1 0 4 4 4 2 BTB/POZ domain BMFP PF04380.13 EFC47739.1 - 0.038 14.5 0.0 0.12 12.9 0.0 1.8 1 0 0 1 1 1 0 Membrane fusogenic activity Cnn_1N PF07989.11 EFC47739.1 - 6.8 6.9 7.3 0.34 11.1 0.5 2.4 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Exo_endo_phos PF03372.23 EFC47740.1 - 1.5e-09 37.7 0.0 4.5e-09 36.2 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFC47740.1 - 0.00011 22.0 0.2 0.47 10.3 0.0 3.3 3 0 0 3 3 3 3 Endonuclease-reverse transcriptase 2OG-FeII_Oxy_2 PF13532.6 EFC47741.1 - 5.6e-24 85.4 0.1 7.2e-24 85.1 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PTase_Orf2 PF11468.8 EFC47742.1 - 0.005 16.3 0.0 0.0099 15.3 0.0 1.4 1 0 0 1 1 1 1 Aromatic prenyltransferase Orf2 DUF1660 PF07874.11 EFC47742.1 - 0.033 14.7 1.4 0.13 12.8 0.1 2.8 3 0 0 3 3 3 0 Prophage protein (DUF1660) T6SS_VasJ PF16989.5 EFC47742.1 - 0.12 11.9 0.1 0.18 11.3 0.1 1.2 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ Pkinase PF00069.25 EFC47743.1 - 4.1e-41 141.1 4.7 7.9e-41 140.2 4.7 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47743.1 - 1.4e-28 99.9 0.1 2.1e-28 99.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC47743.1 - 1.8e-16 59.2 5.7 0.0076 16.2 0.1 7.4 7 0 0 7 7 7 4 NHL repeat Pkinase_fungal PF17667.1 EFC47743.1 - 2.2e-06 26.7 0.0 4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 EFC47743.1 - 0.0013 17.8 0.2 0.0024 16.9 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Cyclotide PF03784.13 EFC47743.1 - 1.5 9.0 6.9 3.1 8.0 6.9 1.4 1 0 0 1 1 1 0 Cyclotide family DJ-1_PfpI PF01965.24 EFC47744.1 - 3.4e-24 85.5 0.0 5.6e-24 84.8 0.0 1.4 1 1 0 1 1 1 1 DJ-1/PfpI family NUDIX PF00293.28 EFC47745.1 - 1.3e-07 31.7 0.0 1.6e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain TrmO PF01980.16 EFC47747.1 - 5.3e-37 126.6 0.1 1.5e-35 122.0 0.1 2.3 1 1 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 EFC47747.1 - 1.1e-08 35.0 0.0 2.4e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 TrmO C-terminal domain Presenilin PF01080.17 EFC47747.1 - 0.32 9.7 4.5 0.44 9.3 4.5 1.2 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 EFC47747.1 - 1.3 9.6 26.7 0.19 12.3 6.2 3.1 3 0 0 3 3 3 0 Secretin N-terminal domain DUF4636 PF15468.6 EFC47747.1 - 2.5 7.7 8.2 8.4 6.0 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4636) DUF4834 PF16118.5 EFC47747.1 - 5.5 8.0 8.8 4.8 8.2 0.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) G-alpha PF00503.20 EFC47748.1 - 2.5e-48 165.1 9.8 2.9e-48 164.8 9.8 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC47748.1 - 0.00041 19.8 0.1 0.27 10.7 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family TsaE PF02367.17 EFC47748.1 - 0.026 14.5 1.0 6.8 6.7 0.1 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EFC47748.1 - 0.061 13.8 0.5 0.26 11.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC47748.1 - 0.062 13.6 1.0 0.22 11.8 0.3 2.2 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFC47748.1 - 0.069 13.4 0.0 0.16 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain Peptidase_S78_2 PF14550.6 EFC47748.1 - 0.12 12.4 0.2 0.31 11.1 0.2 1.6 1 0 0 1 1 1 0 Putative phage serine protease XkdF NB-ARC PF00931.22 EFC47748.1 - 0.19 10.9 1.4 0.22 10.7 0.4 1.7 2 1 0 2 2 2 0 NB-ARC domain RhoGEF PF00621.20 EFC47749.1 - 3.2e-32 112.2 6.0 3.2e-32 112.2 6.0 5.6 5 2 0 5 5 5 1 RhoGEF domain IQ PF00612.27 EFC47749.1 - 3.8e-14 51.1 17.9 0.49 10.3 0.0 13.6 14 0 0 14 14 14 4 IQ calmodulin-binding motif RGS PF00615.19 EFC47749.1 - 1.7e-11 44.4 0.4 1.7e-11 44.4 0.4 4.0 4 0 0 4 4 4 1 Regulator of G protein signaling domain LRR_8 PF13855.6 EFC47749.1 - 3.4e-09 36.3 26.3 7.3e-06 25.7 0.5 4.6 4 1 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 EFC47749.1 - 5.1e-07 29.9 39.7 0.0023 18.3 3.3 6.4 4 2 1 6 6 6 4 Leucine Rich repeats (2 copies) PH_10 PF15411.6 EFC47749.1 - 0.0026 18.0 1.9 0.022 15.0 1.9 2.8 1 0 0 1 1 1 1 Pleckstrin homology domain LRR_6 PF13516.6 EFC47749.1 - 0.14 12.3 20.1 6.1 7.2 0.5 5.8 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 EFC47749.1 - 2.1 9.2 24.4 12 6.9 0.3 7.4 8 0 0 8 8 8 0 Leucine Rich Repeat EGF_2 PF07974.13 EFC47750.1 - 8.1e-08 32.5 33.2 0.015 15.6 6.4 3.5 3 0 0 3 3 3 3 EGF-like domain hEGF PF12661.7 EFC47750.1 - 0.00044 20.8 36.9 0.18 12.5 7.9 4.0 3 0 0 3 3 3 3 Human growth factor-like EGF RR_TM4-6 PF06459.12 EFC47750.1 - 0.06 13.2 13.0 0.12 12.2 13.0 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRN3 PF05327.11 EFC47750.1 - 0.17 10.4 7.1 0.24 9.9 7.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MORN PF02493.20 EFC47750.1 - 1.2 9.2 3.0 64 3.7 0.1 3.3 3 0 0 3 3 3 0 MORN repeat PTPRCAP PF15713.5 EFC47750.1 - 6.1 7.1 7.4 10 6.4 7.4 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DEAD PF00270.29 EFC47751.1 - 4.4e-06 26.6 0.0 5e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC47751.1 - 0.025 14.6 0.0 0.029 14.4 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 EFC47755.1 - 8.4e-12 45.1 0.1 1.6e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC47755.1 - 0.00034 20.8 0.1 0.0009 19.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain G-alpha PF00503.20 EFC47756.1 - 2.6e-84 283.4 4.7 2.9e-84 283.3 4.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC47756.1 - 3.6e-12 46.1 5.9 5.4e-11 42.3 0.1 3.0 2 1 1 3 3 3 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC47756.1 - 0.00012 22.2 0.8 0.091 12.8 0.0 2.5 2 1 0 2 2 2 2 50S ribosome-binding GTPase SRPRB PF09439.10 EFC47756.1 - 0.00036 20.0 3.4 0.11 11.9 0.1 2.8 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC47756.1 - 0.0015 17.9 0.3 0.0015 17.9 0.3 2.4 3 0 0 3 3 3 1 Gtr1/RagA G protein conserved region Amidase PF01425.21 EFC47756.1 - 0.0042 16.1 0.1 0.0055 15.7 0.1 1.1 1 0 0 1 1 1 1 Amidase GTP_EFTU PF00009.27 EFC47756.1 - 0.011 15.3 0.1 1.1 8.8 0.0 2.5 1 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Roc PF08477.13 EFC47756.1 - 0.03 14.5 0.2 5.3 7.3 0.1 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF4795 PF16043.5 EFC47756.1 - 0.075 12.6 3.5 0.23 11.1 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) AAA_18 PF13238.6 EFC47756.1 - 0.075 13.6 0.3 0.26 11.8 0.2 2.0 1 1 1 2 2 2 0 AAA domain YgbB PF02542.16 EFC47756.1 - 0.14 12.4 0.4 0.69 10.2 0.3 1.9 1 1 1 2 2 2 0 YgbB family PIF1 PF05970.14 EFC47756.1 - 0.62 9.2 5.4 0.29 10.2 1.1 2.1 2 1 1 3 3 3 0 PIF1-like helicase Pkinase PF00069.25 EFC47757.1 - 8e-57 192.6 0.4 9.1e-57 192.4 0.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47757.1 - 4.1e-22 78.7 0.0 6.1e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LRR_6 PF13516.6 EFC47758.1 - 2.7e-22 76.9 14.5 0.0023 17.9 0.0 8.5 9 0 0 9 9 9 5 Leucine Rich repeat LRR_8 PF13855.6 EFC47758.1 - 1.6e-19 69.4 11.8 3.8e-07 29.8 0.2 4.5 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 EFC47758.1 - 3.3e-16 59.1 19.9 0.00037 20.8 0.4 5.6 2 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47758.1 - 2.1e-07 30.5 7.7 42 5.3 0.0 8.3 9 0 0 9 9 9 0 Leucine Rich Repeat DUF4347 PF14252.6 EFC47758.1 - 0.00099 19.0 0.2 0.67 9.8 0.0 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4347) CLU_N PF15044.6 EFC47758.1 - 0.005 17.2 3.7 6.7 7.1 0.0 4.0 2 2 2 4 4 4 2 Mitochondrial function, CLU-N-term F-box-like PF12937.7 EFC47758.1 - 0.0082 16.0 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 F-box-like Glyco_hydro_20 PF00728.22 EFC47760.1 - 1.8e-52 178.9 1.0 1.4e-50 172.7 1.0 2.3 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFC47760.1 - 2e-05 25.3 3.8 2.9e-05 24.8 0.6 2.7 2 1 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFC47760.1 - 3.8e-05 24.5 0.0 9.9e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 AP_endonuc_2 PF01261.24 EFC47760.1 - 0.18 11.2 0.0 0.38 10.2 0.0 1.4 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Radical_SAM PF04055.21 EFC47762.1 - 4.8e-13 49.8 0.1 7.6e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily LIAS_N PF16881.5 EFC47762.1 - 3.4e-06 27.4 0.2 6.6e-06 26.5 0.2 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family GSHPx PF00255.19 EFC47763.1 - 5e-43 145.1 2.4 6.4e-43 144.7 2.4 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EFC47763.1 - 2.9e-08 33.7 0.4 6e-08 32.7 0.4 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 EFC47763.1 - 2e-06 27.6 0.2 2.4e-05 24.1 0.2 2.5 1 1 0 1 1 1 1 Redoxin Pombe_5TM PF09437.10 EFC47763.1 - 0.082 12.5 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 Pombe specific 5TM protein CitMHS PF03600.16 EFC47764.1 - 2e-43 148.7 0.0 4.6e-34 118.0 0.0 2.4 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 EFC47764.1 - 5.5e-09 35.6 15.5 5.5e-09 35.6 15.5 3.0 2 1 0 2 2 2 1 Sodium:sulfate symporter transmembrane region TrkA_C PF02080.21 EFC47764.1 - 0.0031 17.3 0.5 0.23 11.3 0.2 3.3 3 1 0 3 3 3 1 TrkA-C domain Anophelin PF10731.9 EFC47764.1 - 0.17 11.8 0.3 0.55 10.1 0.3 1.9 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito SelP_N PF04592.14 EFC47765.1 - 0.11 11.9 5.8 0.21 10.9 5.8 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AMP-binding PF00501.28 EFC47766.1 - 4.1e-94 315.6 0.0 6e-94 315.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme adh_short PF00106.25 EFC47766.1 - 4.3e-39 134.0 0.1 7.6e-39 133.2 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC47766.1 - 7.7e-39 133.6 0.0 1.4e-38 132.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase AMP-binding_C PF13193.6 EFC47766.1 - 1.4e-18 67.6 0.0 4.4e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain KR PF08659.10 EFC47766.1 - 3.4e-06 27.1 0.0 6e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 EFC47766.1 - 0.087 12.2 0.0 0.23 10.8 0.0 1.7 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 EFC47766.1 - 0.14 11.3 0.1 0.29 10.2 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 2OG-FeII_Oxy_3 PF13640.6 EFC47767.1 - 9.3e-11 42.5 0.0 1.8e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box PF00646.33 EFC47768.1 - 2.5e-13 49.5 5.2 2.3e-11 43.3 0.4 3.1 2 0 0 2 2 2 2 F-box domain F-box-like PF12937.7 EFC47768.1 - 6.9e-07 29.1 8.0 9.3e-07 28.7 0.2 3.6 4 0 0 4 4 4 1 F-box-like PRANC PF09372.10 EFC47768.1 - 0.063 13.6 0.0 0.063 13.6 0.0 3.2 4 0 0 4 4 4 0 PRANC domain LRR_1 PF00560.33 EFC47768.1 - 0.24 12.1 13.3 25 6.0 0.4 6.0 5 1 1 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 EFC47768.1 - 1.1 9.0 9.5 2.5 7.9 0.4 4.0 4 0 0 4 4 4 0 Leucine rich repeat LRR_4 PF12799.7 EFC47768.1 - 3.9 8.0 22.0 0.089 13.3 2.1 5.6 6 3 2 8 8 8 0 Leucine Rich repeats (2 copies) Aa_trans PF01490.18 EFC47769.1 - 1.1e-40 139.6 35.4 1.3e-40 139.3 35.4 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein FAA_hydrolase PF01557.18 EFC47770.1 - 1.6e-49 168.6 0.0 1.9e-49 168.3 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family KH_4 PF13083.6 EFC47770.1 - 0.086 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 KH domain KH_2 PF07650.17 EFC47770.1 - 0.14 12.0 2.0 0.15 11.9 0.1 2.0 3 0 0 3 3 3 0 KH domain Pkinase PF00069.25 EFC47771.1 - 3.7e-70 236.3 0.0 4.5e-70 236.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47771.1 - 3.8e-35 121.4 0.1 7e-35 120.5 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC47771.1 - 1.4e-06 27.8 0.3 2.2e-06 27.2 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFC47771.1 - 0.00049 19.1 0.7 0.00072 18.6 0.7 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFC47771.1 - 0.0016 17.8 0.1 0.0054 16.1 0.0 1.8 1 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 EFC47771.1 - 0.0067 16.1 0.2 0.011 15.3 0.2 1.4 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 CdiI_4 PF18624.1 EFC47771.1 - 0.019 15.4 0.3 0.034 14.6 0.3 1.4 1 0 0 1 1 1 0 CDI immunity protein RIO1 PF01163.22 EFC47771.1 - 0.029 14.0 0.9 0.049 13.2 0.5 1.5 2 0 0 2 2 2 0 RIO1 family Seadorna_VP7 PF07387.11 EFC47771.1 - 0.054 12.5 1.0 0.14 11.2 0.1 1.8 1 1 0 2 2 2 0 Seadornavirus VP7 APH PF01636.23 EFC47771.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family LRR_4 PF12799.7 EFC47772.1 - 9.7e-05 22.7 27.5 0.16 12.4 1.2 6.2 3 2 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47772.1 - 0.0049 16.6 20.3 0.11 12.3 0.2 5.9 4 2 3 7 7 7 3 Leucine rich repeat LRR_6 PF13516.6 EFC47772.1 - 0.13 12.4 14.4 0.61 10.3 0.3 5.4 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 EFC47772.1 - 0.35 11.6 7.4 7.9 7.5 0.0 5.1 6 0 0 6 6 6 0 Leucine Rich Repeat Peptidase_C1 PF00112.23 EFC47773.1 - 9.5e-43 146.8 1.8 1.1e-42 146.6 1.8 1.0 1 0 0 1 1 1 1 Papain family cysteine protease PI-PLC-C1 PF16670.5 EFC47775.1 - 1.4e-32 113.1 1.3 6.9e-22 78.0 0.0 3.6 1 1 1 2 2 2 2 Phosphoinositide phospholipase C, Ca2+-dependent DUF2312 PF10073.9 EFC47775.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF4175 PF13779.6 EFC47775.1 - 0.84 7.5 7.1 1.2 7.0 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Arm PF00514.23 EFC47776.1 - 1.1e-14 53.9 6.5 8.3e-08 32.0 0.2 4.7 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 EFC47776.1 - 2.7e-06 27.5 1.1 0.00074 19.7 0.7 3.0 1 1 1 2 2 2 2 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 EFC47776.1 - 0.00025 21.0 1.2 0.0031 17.5 0.2 2.7 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 EFC47776.1 - 0.011 16.3 0.0 0.045 14.3 0.0 2.0 2 0 0 2 2 2 0 HEAT-like repeat HEAT PF02985.22 EFC47776.1 - 0.023 14.9 0.0 0.29 11.5 0.0 2.5 2 0 0 2 2 2 0 HEAT repeat Phage_CP76 PF06892.11 EFC47776.1 - 0.041 13.4 0.1 7 6.2 0.0 2.4 2 1 0 2 2 2 0 Phage regulatory protein CII (CP76) HEAT_2 PF13646.6 EFC47776.1 - 0.1 13.0 0.0 1.3 9.5 0.0 2.5 2 1 2 4 4 4 0 HEAT repeats SGL PF08450.12 EFC47777.1 - 4.3e-05 23.2 0.0 0.33 10.5 0.0 2.5 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region PARP PF00644.20 EFC47778.1 - 2.6e-14 53.2 0.2 6.5e-14 52.0 0.2 1.6 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF2156 PF09924.9 EFC47778.1 - 0.012 14.7 0.2 0.02 13.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) zf-C3HC4_5 PF17121.5 EFC47778.1 - 0.043 13.7 1.3 2.1 8.3 0.1 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Ets PF00178.22 EFC47778.1 - 0.33 11.5 4.5 0.25 11.8 2.1 2.1 2 0 0 2 2 2 0 Ets-domain NEMO PF11577.8 EFC47778.1 - 9.2 6.4 13.6 0.99 9.5 8.7 1.9 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Arrestin_C PF02752.22 EFC47779.1 - 3.4e-19 69.6 1.2 7.3e-17 62.1 0.4 2.8 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 EFC47779.1 - 8.9e-18 64.8 0.1 1.2e-09 38.3 0.0 3.2 3 0 0 3 3 3 3 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 EFC47779.1 - 3.8e-09 36.4 0.0 6.9e-06 25.7 0.1 2.9 3 0 0 3 3 3 2 SpoOM protein Rgp1 PF08737.10 EFC47779.1 - 0.016 14.4 0.0 0.88 8.7 0.1 2.5 2 1 1 3 3 3 0 Rgp1 Cna_B PF05738.13 EFC47779.1 - 0.026 15.0 0.2 0.21 12.1 0.1 2.3 2 0 0 2 2 2 0 Cna protein B-type domain YbjQ_1 PF01906.17 EFC47780.1 - 0.052 14.2 4.7 60 4.4 0.0 5.2 5 1 2 7 7 7 0 Putative heavy-metal-binding TRPM_tetra PF16519.5 EFC47780.1 - 0.13 12.4 0.3 42 4.3 0.0 3.6 3 0 0 3 3 3 0 Tetramerisation domain of TRPM DegS PF05384.11 EFC47780.1 - 1.5 8.3 11.5 8.6 5.8 0.1 4.2 5 1 0 5 5 5 0 Sensor protein DegS Imm3 PF14425.6 EFC47780.1 - 8.9 6.4 10.3 37 4.4 0.3 5.1 3 1 2 5 5 5 0 Immunity protein Imm3 C2 PF00168.30 EFC47782.1 - 5.4e-13 49.1 0.0 1.1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain Ribosomal_S3Ae PF01015.18 EFC47782.1 - 0.12 11.9 1.0 0.19 11.2 1.0 1.3 1 0 0 1 1 1 0 Ribosomal S3Ae family TPR_1 PF00515.28 EFC47784.1 - 3.4e-07 29.8 9.7 2.2e-05 24.1 1.1 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47784.1 - 5e-06 26.2 0.2 0.043 13.9 0.5 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47784.1 - 1.7e-05 24.7 1.2 0.04 14.1 0.3 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC47784.1 - 2.6e-05 24.3 0.1 0.0075 16.4 0.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47784.1 - 0.00075 19.7 0.1 0.19 12.0 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC47784.1 - 0.0052 17.1 0.6 1.4 9.5 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47784.1 - 0.0059 16.3 0.3 1.3 8.8 0.2 3.3 2 0 0 2 2 2 1 TPR repeat TPR_6 PF13174.6 EFC47784.1 - 0.034 14.8 0.1 2.8 8.7 0.4 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47784.1 - 0.13 12.3 2.7 7.9 6.8 0.3 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat AMP-binding PF00501.28 EFC47786.1 - 8e-170 565.0 0.0 5.1e-93 312.0 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 EFC47786.1 - 1.7e-97 327.0 10.4 2.6e-97 326.4 10.4 1.3 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 EFC47786.1 - 1.1e-25 89.8 0.2 9.1e-13 48.4 0.0 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 EFC47786.1 - 3.4e-08 34.4 0.0 3.2e-07 31.2 0.0 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain AMP-binding_C_2 PF14535.6 EFC47786.1 - 0.039 14.3 0.0 0.21 11.9 0.0 2.4 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain DUF325 PF03804.13 EFC47787.1 - 0.26 11.3 1.3 10 6.2 0.0 3.4 4 0 0 4 4 4 0 Viral proteins of unknown function 2_5_RNA_ligase2 PF13563.6 EFC47788.1 - 2.5e-33 115.1 0.0 3.1e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 EFC47788.1 - 0.00012 22.2 0.0 0.02 15.1 0.0 2.6 3 0 0 3 3 3 2 LigT like Phosphoesterase DUF4294 PF14127.6 EFC47788.1 - 0.082 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) Pyr_redox_2 PF07992.14 EFC47789.1 - 8.8e-72 241.8 3.0 1.4e-71 241.1 3.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFC47789.1 - 6.1e-41 139.1 2.0 6.7e-41 139.0 0.3 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 EFC47789.1 - 6.7e-21 74.6 6.0 1.7e-17 63.8 0.3 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 EFC47789.1 - 9.1e-12 44.7 1.6 4.4e-10 39.2 0.3 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EFC47789.1 - 6.5e-10 38.8 2.9 4.5e-06 26.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 EFC47789.1 - 7.7e-10 38.7 0.2 1.5e-09 37.7 0.2 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC47789.1 - 3.9e-09 36.6 2.2 0.00011 22.3 1.0 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFC47789.1 - 2.2e-08 33.6 7.0 1.9e-06 27.2 2.0 3.0 3 0 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.21 EFC47789.1 - 2.5e-06 27.0 5.5 0.0094 15.3 0.1 2.9 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 EFC47789.1 - 7.6e-05 21.6 10.2 0.00067 18.5 1.2 3.9 3 1 1 4 4 4 1 HI0933-like protein Thi4 PF01946.17 EFC47789.1 - 0.00013 21.3 1.3 0.0012 18.2 0.1 2.5 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 EFC47789.1 - 0.0002 20.7 4.4 0.037 13.3 1.0 2.3 2 0 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.6 EFC47789.1 - 0.00042 19.6 0.2 0.0099 15.0 0.0 2.6 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 EFC47789.1 - 0.01 15.7 1.6 0.016 15.1 0.2 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 EFC47789.1 - 0.015 14.9 0.1 0.015 14.9 0.1 2.2 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 EFC47789.1 - 0.029 13.7 0.4 0.97 8.8 0.0 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 EFC47789.1 - 0.033 14.6 2.9 5.7 7.4 0.1 2.9 3 0 0 3 3 2 0 Putative NAD(P)-binding DAO PF01266.24 EFC47789.1 - 0.044 13.4 7.4 0.97 8.9 0.5 3.7 4 0 0 4 4 4 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 EFC47789.1 - 0.1 11.7 1.0 8.7 5.3 0.6 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein C2 PF00168.30 EFC47790.1 - 2.9e-22 78.9 0.2 1e-21 77.1 0.1 1.9 1 1 1 2 2 2 1 C2 domain Polysacc_lyase PF14099.6 EFC47790.1 - 0.031 14.1 0.1 0.05 13.4 0.1 1.3 1 0 0 1 1 1 0 Polysaccharide lyase C2 PF00168.30 EFC47791.1 - 2.1e-23 82.6 0.0 3.9e-23 81.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain HRDC PF00570.23 EFC47792.1 - 0.066 13.2 0.0 0.21 11.6 0.0 1.9 1 0 0 1 1 1 0 HRDC domain PBP_N PF17093.5 EFC47792.1 - 0.53 10.5 3.2 5.2 7.3 0.4 2.4 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus PH PF00169.29 EFC47793.1 - 1.7e-50 169.9 6.9 9.1e-19 67.9 0.1 4.7 4 0 0 4 4 4 3 PH domain Beta_helix PF13229.6 EFC47793.1 - 1.1e-15 57.8 15.2 2.7e-11 43.6 11.3 2.1 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 EFC47793.1 - 4.6e-13 49.0 5.1 1e-12 47.8 5.1 1.5 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) PH_8 PF15409.6 EFC47793.1 - 8.7e-12 45.2 0.1 0.0023 18.2 0.2 4.2 3 0 0 3 3 3 2 Pleckstrin homology domain PH_11 PF15413.6 EFC47793.1 - 7.2e-08 32.8 12.3 0.0068 16.8 0.9 5.2 3 2 0 3 3 3 2 Pleckstrin homology domain PH_3 PF14593.6 EFC47793.1 - 3.3e-07 30.3 0.2 0.053 13.6 0.1 3.1 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 EFC47793.1 - 0.00012 22.4 0.6 1.3 9.5 0.1 4.1 4 1 0 4 4 4 2 Pleckstrin homology domain PH_13 PF16652.5 EFC47793.1 - 0.14 11.9 5.0 12 5.7 0.0 3.9 4 0 0 4 4 4 0 Pleckstrin homology domain SYCP2_SLD PF18584.1 EFC47793.1 - 0.3 11.3 4.8 11 6.3 0.1 3.1 3 1 1 4 4 4 0 Synaptonemal complex 2 Spt16M-like domain APG5 PF04106.12 EFC47795.1 - 2.2e-40 138.7 0.3 2.2e-40 138.7 0.3 3.1 3 1 0 3 3 3 1 Autophagy protein Apg5 Forkhead PF00250.18 EFC47795.1 - 4.3e-22 78.2 1.1 2.1e-21 76.0 1.1 2.3 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 EFC47795.1 - 4.5e-06 26.9 0.0 1.2e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 FHA domain Coilin_N PF15862.5 EFC47795.1 - 8.9e-06 25.6 8.3 8.9e-06 25.6 8.3 5.6 6 2 0 6 6 6 1 Coilin N-terminus CtsR_C PF17727.1 EFC47795.1 - 0.0039 17.3 0.0 0.015 15.4 0.0 2.0 1 0 0 1 1 1 1 CtsR C-terminal dimerization domain CPP1-like PF11833.8 EFC47795.1 - 0.016 14.9 0.0 0.016 14.9 0.0 2.8 3 0 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF4228 PF14009.6 EFC47795.1 - 1.8 8.9 0.0 1.8 8.9 0.0 4.6 2 1 0 3 3 3 0 Domain of unknown function (DUF4228) EMC3_TMCO1 PF01956.16 EFC47795.1 - 6 6.6 12.3 0.46 10.2 5.1 2.5 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Metallophos PF00149.28 EFC47796.1 - 1.9e-07 31.8 2.6 2.9e-07 31.2 2.2 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 EFC47796.1 - 0.0033 18.0 0.4 0.023 15.2 0.1 2.5 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Pkinase PF00069.25 EFC47798.1 - 2.5e-42 145.1 0.1 3.1e-42 144.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47798.1 - 6.3e-40 137.1 0.1 7.1e-40 136.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC47798.1 - 0.00034 19.7 0.1 0.003 16.6 0.1 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC47798.1 - 0.0012 18.2 0.1 0.0016 17.8 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YukC PF10140.9 EFC47798.1 - 0.0015 17.5 0.0 0.0019 17.1 0.0 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.23 EFC47798.1 - 0.012 15.5 0.0 0.033 14.1 0.0 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family FIBP PF05427.11 EFC47798.1 - 0.027 13.8 0.1 0.032 13.5 0.1 1.1 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) RIO1 PF01163.22 EFC47798.1 - 0.032 13.8 0.2 0.04 13.5 0.2 1.2 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 EFC47798.1 - 0.049 12.4 0.1 0.069 11.9 0.1 1.2 1 0 0 1 1 1 0 Fungal protein kinase HATPase_c PF02518.26 EFC47799.1 - 3.5e-20 72.6 0.0 7.6e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC47799.1 - 6.2e-19 68.2 0.1 1.4e-18 67.1 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC47799.1 - 1.2e-13 50.9 0.4 3.7e-13 49.3 0.1 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EFC47799.1 - 0.00086 19.2 1.7 0.0086 16.0 0.0 2.7 2 0 0 2 2 2 1 GHKL domain Ras PF00071.22 EFC47800.1 - 4.3e-16 58.9 0.1 6.4e-16 58.4 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47800.1 - 4.1e-06 27.0 0.0 7.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC47800.1 - 0.0059 16.2 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC47800.1 - 0.053 13.4 0.1 0.096 12.6 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase RGS PF00615.19 EFC47801.1 - 1.3e-05 25.5 0.6 2.3e-05 24.7 0.6 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain KELK PF15796.5 EFC47801.1 - 0.99 9.9 4.2 0.16 12.4 0.6 1.6 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase GPS PF01825.21 EFC47802.1 - 1.4e-08 35.1 1.1 1.4e-08 35.1 1.1 4.3 4 1 0 4 4 4 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC47802.1 - 3.3e-07 30.6 133.4 0.00063 20.1 11.8 8.3 8 0 0 8 8 8 6 EGF-like domain Interferon PF00143.19 EFC47802.1 - 0.0097 16.1 0.8 0.021 15.0 0.8 1.5 1 0 0 1 1 1 1 Interferon alpha/beta domain Fascin PF06268.13 EFC47803.1 - 3.2e-31 107.8 0.1 9.1e-10 38.8 0.0 4.5 1 1 4 5 5 5 5 Fascin domain FRG1 PF06229.12 EFC47803.1 - 3.4e-29 101.9 0.0 1.5e-06 28.1 0.0 5.3 1 1 4 5 5 5 5 FRG1-like domain EF-hand_7 PF13499.6 EFC47803.1 - 6.7e-11 42.5 0.3 1.1e-10 41.9 0.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC47803.1 - 3.9e-09 35.7 0.5 0.00056 19.6 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC47803.1 - 2.2e-08 33.0 0.3 0.00052 19.4 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC47803.1 - 3e-06 27.0 0.2 1.1e-05 25.1 0.1 1.9 1 1 1 2 2 2 2 EF-hand domain pair FGF PF00167.18 EFC47803.1 - 0.00024 21.2 0.0 1.5 8.9 0.0 3.4 1 1 2 3 3 3 2 Fibroblast growth factor EF-hand_5 PF13202.6 EFC47803.1 - 0.0096 15.4 0.1 0.12 11.9 0.0 2.3 2 0 0 2 2 2 1 EF hand SOG2 PF10428.9 EFC47803.1 - 0.084 12.1 7.3 0.12 11.6 7.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Stealth_CR1 PF17101.5 EFC47803.1 - 0.11 12.2 0.2 0.22 11.3 0.2 1.4 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 Collar PF07484.12 EFC47804.1 - 3.2e-18 65.5 0.4 5.3e-18 64.8 0.4 1.4 1 0 0 1 1 1 1 Phage Tail Collar Domain 60KD_IMP PF02096.20 EFC47805.1 - 5.9e-23 81.6 0.1 6.7e-23 81.4 0.1 1.0 1 0 0 1 1 1 1 60Kd inner membrane protein NUC194 PF08163.12 EFC47806.1 - 2.2e-75 254.0 2.0 7.1e-75 252.3 2.0 2.0 1 0 0 1 1 1 1 NUC194 domain PI3_PI4_kinase PF00454.27 EFC47806.1 - 3.5e-51 174.4 0.4 1.4e-50 172.5 0.4 2.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EFC47806.1 - 5.4e-24 85.0 6.9 5.4e-24 85.0 6.9 3.1 2 1 1 3 3 3 1 FAT domain FATC PF02260.20 EFC47806.1 - 2.7e-10 39.9 0.0 5.9e-10 38.8 0.0 1.6 1 0 0 1 1 1 1 FATC domain Bac_DNA_binding PF00216.21 EFC47806.1 - 0.042 14.0 0.2 0.67 10.2 0.0 3.0 2 0 0 2 2 2 0 Bacterial DNA-binding protein MIT PF04212.18 EFC47806.1 - 0.045 13.8 0.0 0.82 9.8 0.0 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Adaptin_N PF01602.20 EFC47807.1 - 7.7e-130 433.9 3.6 9.4e-130 433.6 3.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 EFC47807.1 - 8.3e-26 91.0 2.6 9.8e-22 77.7 0.1 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 EFC47807.1 - 1.7e-05 24.7 0.1 0.53 10.7 0.0 5.3 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 EFC47807.1 - 0.00011 22.6 0.1 0.094 13.1 0.0 4.2 2 2 3 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 EFC47807.1 - 0.17 12.4 0.0 2.6 8.6 0.0 3.1 4 0 0 4 4 4 0 HEAT-like repeat VIR_N PF15912.5 EFC47807.1 - 0.76 9.3 17.7 1.2 8.6 17.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal CDC45 PF02724.14 EFC47807.1 - 8.2 4.6 30.9 15 3.7 30.9 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 EFC47807.1 - 9.5 5.1 10.6 19 4.1 10.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ion_trans_2 PF07885.16 EFC47808.1 - 6.2e-23 80.6 30.5 1.1e-14 54.1 13.7 2.6 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EFC47808.1 - 6.2e-06 25.6 20.5 0.0017 17.7 11.4 2.5 1 1 1 2 2 2 2 Ion transport protein HemY_N PF07219.13 EFC47808.1 - 8.7 6.6 5.7 2.5 8.4 0.0 2.8 4 0 0 4 4 4 0 HemY protein N-terminus RCC1_2 PF13540.6 EFC47809.1 - 0.003 17.3 0.0 0.013 15.3 0.0 2.2 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat Muskelin_N PF06588.11 EFC47809.1 - 0.021 14.8 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Muskelin N-terminus DUF89 PF01937.19 EFC47810.1 - 1.1e-61 208.8 5.2 1.4e-61 208.5 5.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF1931 PF09123.11 EFC47810.1 - 0.0029 17.7 0.2 3.5 7.8 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1931) ATP-grasp_4 PF13535.6 EFC47813.1 - 9e-09 35.1 0.1 2.4e-08 33.8 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFC47813.1 - 1.1e-05 25.0 0.0 3.3e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 EFC47813.1 - 0.0001 22.4 0.0 0.00035 20.6 0.0 1.9 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 EFC47813.1 - 0.075 12.3 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp SAP PF02037.27 EFC47814.1 - 6.5e-08 32.2 0.3 0.0012 18.6 0.1 2.9 2 0 0 2 2 2 2 SAP domain MetOD1 PF18546.1 EFC47814.1 - 0.0062 16.5 2.8 0.0062 16.5 2.8 2.4 3 0 0 3 3 3 1 Metanogen output domain 1 DUF913 PF06025.12 EFC47814.1 - 9.8 5.0 11.1 7.7 5.4 5.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) LRR_6 PF13516.6 EFC47815.1 - 8.5e-38 125.2 23.3 9.6e-05 22.1 0.0 12.6 12 0 0 12 12 12 10 Leucine Rich repeat LRR_4 PF12799.7 EFC47815.1 - 1e-15 57.6 27.5 0.012 16.0 0.0 8.7 4 3 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47815.1 - 5.8e-10 38.8 26.3 0.0053 16.5 0.1 7.7 4 2 2 7 7 7 5 Leucine rich repeat LRR_1 PF00560.33 EFC47815.1 - 7.6e-09 34.9 16.4 2.3 9.1 0.4 10.1 8 3 0 8 8 8 3 Leucine Rich Repeat F-box-like PF12937.7 EFC47815.1 - 2.9e-05 23.9 0.4 6.2e-05 22.8 0.4 1.5 1 0 0 1 1 1 1 F-box-like DUF2100 PF09873.9 EFC47815.1 - 0.15 11.9 0.5 2 8.2 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2100) LRR_2 PF07723.13 EFC47815.1 - 1.1 10.0 6.5 1.7 9.5 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC47816.1 - 1.7e-25 86.9 0.5 0.0015 18.4 0.0 6.3 6 0 0 6 6 6 5 Leucine Rich repeat LRR_8 PF13855.6 EFC47816.1 - 3.7e-16 58.6 0.8 6.1e-07 29.1 0.2 3.0 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 EFC47816.1 - 2.4e-11 43.7 11.2 0.0026 18.1 0.5 4.7 1 1 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47816.1 - 8.5e-09 34.8 2.0 18 6.4 0.0 7.1 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC47816.1 - 3.4e-05 23.4 1.5 0.0029 17.2 0.1 2.6 2 1 1 3 3 3 2 Leucine-rich repeat ApoB100_C PF12491.8 EFC47816.1 - 0.04 13.9 8.7 3.7 7.6 0.3 5.0 2 1 4 6 6 6 0 Apolipoprotein B100 C terminal DUF424 PF04242.13 EFC47816.1 - 0.04 14.2 7.4 2 8.7 0.2 3.9 2 1 1 4 4 4 0 Protein of unknown function (DUF424) Apo-VLDL-II PF05418.11 EFC47816.1 - 0.9 10.2 4.1 83 3.8 0.1 3.6 1 1 3 4 4 4 0 Apovitellenin I (Apo-VLDL-II) Actin PF00022.19 EFC47817.1 - 1.7e-50 171.8 0.0 1.9e-50 171.7 0.0 1.0 1 0 0 1 1 1 1 Actin Moulting_cycle PF04870.16 EFC47818.1 - 0.0016 17.8 3.3 0.0019 17.5 3.3 1.0 1 0 0 1 1 1 1 Moulting cycle HIP1_clath_bdg PF16515.5 EFC47818.1 - 0.22 12.1 2.5 0.3 11.7 2.0 1.5 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Ras PF00071.22 EFC47819.1 - 6.3e-27 94.2 0.2 7.7e-27 93.9 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47819.1 - 1.3e-12 48.0 0.0 2.1e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC47819.1 - 0.00044 20.3 0.0 0.00072 19.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 EFC47819.1 - 0.015 15.1 0.1 2.1 8.0 0.0 2.5 2 1 0 2 2 2 0 AAA domain TniB PF05621.11 EFC47819.1 - 0.12 11.7 0.0 0.24 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Pkinase PF00069.25 EFC47820.1 - 5.7e-32 111.1 0.5 1.8e-30 106.2 0.1 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47820.1 - 1.1e-20 74.0 0.0 5.4e-20 71.8 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC47820.1 - 1.6e-05 23.9 0.1 1.6e-05 23.9 0.1 1.8 2 0 0 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFC47820.1 - 0.075 12.6 0.2 0.29 10.6 0.1 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Beta_helix PF13229.6 EFC47821.1 - 3.5e-10 40.0 16.5 6e-07 29.4 4.4 2.7 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 EFC47821.1 - 6.6e-05 22.3 15.1 0.0021 17.4 14.9 2.8 1 1 0 1 1 1 1 Periplasmic copper-binding protein (NosD) PH PF00169.29 EFC47821.1 - 0.00032 21.2 0.4 0.002 18.6 0.0 2.4 3 0 0 3 3 3 1 PH domain Pkinase PF00069.25 EFC47823.1 - 6.5e-48 163.4 0.0 3.4e-47 161.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47823.1 - 3.2e-21 75.8 0.0 5.2e-21 75.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC47823.1 - 0.0012 18.8 0.0 0.0059 16.6 0.0 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC47823.1 - 0.014 14.2 0.2 0.019 13.8 0.2 1.1 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 EFC47823.1 - 0.06 12.3 0.4 0.097 11.6 0.4 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 EFC47823.1 - 0.1 12.2 0.1 0.22 11.1 0.1 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase Acetyltransf_10 PF13673.7 EFC47824.1 - 7.1e-07 29.2 0.0 1.8e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC47824.1 - 1.9e-06 28.2 0.0 1.3e-05 25.6 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC47824.1 - 3.4e-05 24.1 0.0 6.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 EFC47824.1 - 9.3e-05 22.5 0.1 0.00031 20.8 0.1 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC47824.1 - 0.0009 19.2 0.0 0.0025 17.8 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 EFC47824.1 - 0.0019 17.7 0.0 0.0061 16.0 0.0 1.8 1 1 0 1 1 1 1 Putative acetyl-transferase GNAT_acetyltran PF12746.7 EFC47824.1 - 0.07 12.7 0.0 0.2 11.2 0.0 1.8 1 0 0 1 1 1 0 GNAT acetyltransferase Acetyltransf_3 PF13302.7 EFC47824.1 - 0.15 12.7 0.0 0.39 11.4 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA PF00004.29 EFC47825.1 - 2.8e-07 31.0 0.2 2.7e-06 27.9 0.0 2.4 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 EFC47825.1 - 5.4e-06 26.4 0.5 0.12 12.3 0.1 2.5 2 0 0 2 2 2 2 NTPase AAA_24 PF13479.6 EFC47825.1 - 1.1e-05 25.2 0.0 2.4e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFC47825.1 - 1.4e-05 24.6 0.3 0.0071 15.7 0.0 2.3 2 0 0 2 2 2 2 KaiC AAA_16 PF13191.6 EFC47825.1 - 2e-05 25.0 0.1 0.00013 22.4 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 EFC47825.1 - 3.2e-05 24.5 0.0 6.2e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC47825.1 - 8.2e-05 22.9 0.3 0.00041 20.6 0.3 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EFC47825.1 - 0.00011 21.5 0.0 0.00023 20.5 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_5 PF07728.14 EFC47825.1 - 0.00012 22.1 0.1 0.00042 20.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 EFC47825.1 - 0.00019 21.1 1.0 0.0099 15.5 1.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 EFC47825.1 - 0.00028 20.7 0.2 0.0012 18.5 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 EFC47825.1 - 0.00033 20.2 0.0 0.00068 19.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 EFC47825.1 - 0.00036 19.7 0.6 0.00053 19.1 0.6 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein GvpD PF07088.11 EFC47825.1 - 0.0006 18.5 0.0 0.0009 18.0 0.0 1.2 1 0 0 1 1 1 1 GvpD gas vesicle protein TsaE PF02367.17 EFC47825.1 - 0.00071 19.6 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 EFC47825.1 - 0.0012 19.4 0.5 0.0094 16.5 0.3 2.4 2 1 0 2 2 2 1 ABC transporter Viral_helicase1 PF01443.18 EFC47825.1 - 0.0016 18.2 0.0 0.0025 17.6 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 EFC47825.1 - 0.0028 17.7 0.0 0.0094 16.0 0.0 1.9 1 1 0 1 1 1 1 AAA domain TrwB_AAD_bind PF10412.9 EFC47825.1 - 0.0036 16.3 0.2 0.0085 15.0 0.0 1.6 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain TniB PF05621.11 EFC47825.1 - 0.0053 16.2 0.4 0.099 12.0 0.4 2.3 1 1 0 1 1 1 1 Bacterial TniB protein AAA_33 PF13671.6 EFC47825.1 - 0.0062 16.7 0.1 0.018 15.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EFC47825.1 - 0.008 16.1 0.1 0.019 14.9 0.0 1.6 2 0 0 2 2 1 1 NACHT domain FtsK_SpoIIIE PF01580.18 EFC47825.1 - 0.011 15.2 0.0 0.023 14.0 0.0 1.6 1 1 0 1 1 1 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 EFC47825.1 - 0.011 15.5 0.1 0.61 9.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 EFC47825.1 - 0.015 15.7 0.2 0.077 13.3 0.0 2.0 1 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFC47825.1 - 0.015 15.6 0.0 0.086 13.2 0.0 2.3 2 1 0 2 2 2 0 RNA helicase CbiA PF01656.23 EFC47825.1 - 0.019 15.0 0.1 0.059 13.4 0.1 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 EFC47825.1 - 0.023 14.5 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_2 PF07724.14 EFC47825.1 - 0.024 14.8 0.3 0.14 12.3 0.1 2.2 3 0 0 3 3 2 0 AAA domain (Cdc48 subfamily) AAA_11 PF13086.6 EFC47825.1 - 0.025 14.4 0.0 0.13 12.1 0.0 1.9 1 1 1 2 2 2 0 AAA domain SRP54 PF00448.22 EFC47825.1 - 0.029 14.0 0.1 0.12 12.0 0.1 2.1 1 1 1 2 2 2 0 SRP54-type protein, GTPase domain KTI12 PF08433.10 EFC47825.1 - 0.032 13.7 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 cobW PF02492.19 EFC47825.1 - 0.048 13.2 0.1 0.14 11.7 0.1 1.9 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 EFC47825.1 - 0.069 13.4 0.1 0.23 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain Gp-FAR-1 PF05823.12 EFC47825.1 - 0.11 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) MMR_HSR1 PF01926.23 EFC47825.1 - 0.12 12.5 0.1 0.33 11.1 0.1 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC47825.1 - 0.12 12.3 0.1 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Pox_A32 PF04665.12 EFC47825.1 - 0.12 11.8 0.0 0.27 10.7 0.0 1.7 1 1 0 1 1 1 0 Poxvirus A32 protein AAA_3 PF07726.11 EFC47825.1 - 0.12 12.2 0.1 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 EFC47825.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain BNR_assoc_N PF14873.6 EFC47826.1 - 0.034 13.8 0.2 0.1 12.3 0.1 1.9 1 1 1 2 2 2 0 N-terminal domain of BNR-repeat neuraminidase DUF2682 PF10909.8 EFC47826.1 - 0.082 13.4 9.5 1.2 9.6 1.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2682) TMEM151 PF14857.6 EFC47827.1 - 5.3e-23 81.6 4.7 5.3e-23 81.6 4.7 2.0 1 1 0 2 2 2 2 TMEM151 family GPR15L PF15854.5 EFC47828.1 - 1.6 9.0 8.4 0.062 13.5 2.5 1.8 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 TPR_12 PF13424.6 EFC47829.1 - 3.5e-18 65.6 1.6 2.2e-06 27.8 0.0 4.8 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47829.1 - 1.1e-17 62.7 17.1 0.002 18.2 0.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47829.1 - 3.5e-17 61.1 9.4 0.00035 20.5 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47829.1 - 8.9e-17 60.1 12.1 0.0054 16.5 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC47829.1 - 6.5e-14 51.2 5.8 0.0079 16.5 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC47829.1 - 3.5e-10 39.4 1.1 0.0013 18.6 0.1 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47829.1 - 2.6e-09 37.4 0.7 0.012 16.1 0.0 4.6 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47829.1 - 7e-07 29.8 0.0 0.25 12.0 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47829.1 - 7.1e-07 28.8 1.3 0.16 12.1 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC47829.1 - 2.2e-06 28.0 0.0 0.0071 17.1 0.0 4.8 4 2 2 6 6 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC47829.1 - 1.5e-05 24.9 0.0 0.00047 20.2 0.0 3.1 1 1 1 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EFC47829.1 - 2.5e-05 24.6 0.1 0.48 11.2 0.0 5.9 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC47829.1 - 0.0018 18.4 7.1 0.015 15.5 0.3 2.8 3 0 0 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 EFC47829.1 - 0.0019 18.5 0.3 0.31 11.4 0.0 3.0 3 1 0 3 3 2 1 Tetratricopeptide repeat PPTA PF01239.22 EFC47829.1 - 0.0031 17.2 1.0 0.013 15.2 0.1 2.5 2 0 0 2 2 2 1 Protein prenyltransferase alpha subunit repeat Alkyl_sulf_dimr PF14863.6 EFC47829.1 - 0.0076 16.7 0.2 0.22 12.0 0.0 2.5 2 0 0 2 2 2 1 Alkyl sulfatase dimerisation MAS20 PF02064.15 EFC47829.1 - 1.4 9.0 6.2 0.95 9.6 1.0 2.8 3 0 0 3 3 3 0 MAS20 protein import receptor WD40 PF00400.32 EFC47830.1 - 2.2e-35 120.1 15.7 1.4e-05 25.7 1.1 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47830.1 - 1.1e-12 48.1 2.6 0.21 11.9 0.2 5.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC47830.1 - 1.5e-07 30.5 12.2 0.14 10.7 0.0 5.0 2 1 3 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFC47830.1 - 0.008 14.7 0.2 0.5 8.8 0.0 2.8 1 1 0 2 2 2 1 Cytochrome D1 heme domain CPSF_A PF03178.15 EFC47830.1 - 0.047 13.0 0.0 0.78 9.0 0.0 2.5 2 1 1 3 3 3 0 CPSF A subunit region VID27 PF08553.10 EFC47830.1 - 0.06 12.4 0.0 0.13 11.3 0.0 1.6 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain DUF1768 PF08719.11 EFC47831.1 - 2.2e-48 164.5 0.2 2.6e-48 164.3 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Phage_30_3 PF08010.11 EFC47831.1 - 8.7e-05 22.4 0.1 0.0013 18.6 0.1 2.0 1 1 0 1 1 1 1 Bacteriophage protein GP30.3 LRR_6 PF13516.6 EFC47833.1 - 1.6e-36 121.2 25.9 1.1e-05 25.0 0.2 13.4 14 0 0 14 14 14 8 Leucine Rich repeat LRR_8 PF13855.6 EFC47833.1 - 1e-27 95.6 26.9 2.4e-08 33.6 0.9 6.7 4 2 4 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC47833.1 - 4.8e-25 87.2 29.8 1.8e-05 25.0 0.5 9.1 1 1 7 10 10 10 9 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47833.1 - 1.4e-10 40.2 19.3 2.9 8.8 0.0 11.4 14 0 0 14 14 14 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC47833.1 - 2.7e-06 27.0 12.7 0.078 12.5 0.1 4.0 1 1 1 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC47833.1 - 0.012 15.5 0.1 43 3.9 0.0 4.5 4 2 1 5 5 5 0 Domain of unknown function (DUF4347) LRR_3 PF07725.12 EFC47833.1 - 0.013 15.4 0.5 0.3 11.0 0.2 3.7 2 0 0 2 2 2 0 Leucine Rich Repeat VirE_N PF08800.10 EFC47833.1 - 0.017 15.2 0.0 8.6 6.5 0.0 2.8 2 1 1 3 3 3 0 VirE N-terminal domain PDGF_N PF04692.13 EFC47833.1 - 0.079 13.7 2.9 18 6.2 0.0 3.4 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region Beta_helix PF13229.6 EFC47833.1 - 3.2 7.6 6.5 16 5.3 5.3 2.4 1 1 1 2 2 2 0 Right handed beta helix region PGPGW PF09656.10 EFC47835.1 - 0.22 11.0 0.0 0.22 11.0 0.0 2.0 3 0 0 3 3 3 0 Putative transmembrane protein (PGPGW) DUF4956 PF16316.5 EFC47835.1 - 2.4 7.8 6.2 4.3 7.0 6.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4956) CBS PF00571.28 EFC47837.1 - 4.4e-15 55.9 1.5 0.015 15.7 0.0 4.6 4 0 0 4 4 4 4 CBS domain Band_7 PF01145.25 EFC47838.1 - 7.9e-07 29.2 0.1 1.3e-06 28.5 0.1 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family BTB_2 PF02214.22 EFC47839.1 - 0.00028 21.2 3.4 0.00096 19.5 2.1 2.2 2 1 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 EFC47839.1 - 0.0076 16.5 0.6 0.015 15.6 0.6 1.5 1 1 0 1 1 1 1 BTB/POZ domain Cpn60_TCP1 PF00118.24 EFC47840.1 - 2.6e-150 501.3 15.3 3e-150 501.1 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PMM PF03332.13 EFC47841.1 - 1.8e-102 341.8 3.8 2.1e-102 341.5 3.8 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 EFC47841.1 - 1e-10 41.8 0.2 2.6e-10 40.5 0.2 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EFC47841.1 - 6.4e-05 22.6 0.0 0.11 12.0 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 EFC47841.1 - 0.17 12.1 0.5 0.58 10.4 0.5 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF848 PF05852.11 EFC47842.1 - 0.0017 18.5 4.6 0.0023 18.0 4.6 1.1 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) DUF2120 PF09893.9 EFC47842.1 - 0.054 13.6 4.2 0.07 13.2 4.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DUF5340 PF17275.2 EFC47842.1 - 0.096 12.8 1.7 4.3 7.5 0.2 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5340) RNase_J_C PF17770.1 EFC47842.1 - 0.14 13.2 2.5 0.28 12.2 2.5 1.6 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain ALG11_N PF15924.5 EFC47843.1 - 1.8e-74 250.3 1.1 2.7e-74 249.8 1.1 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 EFC47843.1 - 1.5e-25 89.7 0.1 5e-25 88.0 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFC47843.1 - 4.6e-10 40.0 0.0 5.8e-09 36.5 0.0 2.3 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 EFC47843.1 - 2.4e-05 24.7 0.0 5.8e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFC47843.1 - 0.012 15.6 0.0 0.076 13.0 0.0 2.2 1 1 0 1 1 1 0 Glycosyltransferase Family 4 PfkB PF00294.24 EFC47844.1 - 9.2e-09 35.0 0.0 3.4e-08 33.2 0.0 1.8 1 1 0 1 1 1 1 pfkB family carbohydrate kinase MICSWaP PF17018.5 EFC47844.1 - 0.0066 16.0 0.4 0.017 14.6 0.4 1.7 1 0 0 1 1 1 1 Spore wall protein Cpn60_TCP1 PF00118.24 EFC47845.1 - 1e-154 515.9 6.3 1.1e-154 515.7 6.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Asparaginase_2 PF01112.18 EFC47846.1 - 9.1e-07 28.2 0.1 3.3e-06 26.3 0.1 1.8 1 1 1 2 2 2 1 Asparaginase Ribosomal_S3_C PF00189.20 EFC47846.1 - 0.19 12.3 0.0 0.47 11.0 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S3, C-terminal domain Mucin PF01456.17 EFC47846.1 - 3.3 7.7 13.0 5 7.1 13.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein LRR_6 PF13516.6 EFC47847.1 - 7.7e-41 134.7 14.6 2.9e-05 23.8 0.0 10.4 10 0 0 10 10 10 7 Leucine Rich repeat LRR_8 PF13855.6 EFC47847.1 - 6.9e-26 89.8 29.2 2.5e-07 30.4 0.0 4.7 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC47847.1 - 2.6e-19 69.0 28.2 1.8e-05 25.0 1.1 7.0 1 1 8 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47847.1 - 1.6e-10 40.0 12.1 3.8 8.4 0.0 9.2 8 2 1 9 9 9 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC47847.1 - 2.2e-08 33.8 9.1 0.00024 20.6 0.5 3.7 1 1 3 4 4 4 3 Leucine-rich repeat DUF4347 PF14252.6 EFC47847.1 - 0.00026 20.9 0.1 0.48 10.3 0.0 4.5 1 1 3 4 4 4 1 Domain of unknown function (DUF4347) PulA_N1 PF17999.1 EFC47847.1 - 1.2 10.0 7.4 16 6.3 0.1 3.8 1 1 2 3 3 3 0 Pullulanase N1-terminal domain DUF5365 PF17326.2 EFC47847.1 - 1.9 8.9 6.1 4.1 7.8 0.4 3.1 1 1 0 2 2 2 0 Family of unknown function (DUF5365) YjcQ PF09639.10 EFC47847.1 - 2.6 8.3 13.3 17 5.7 0.5 5.3 2 2 2 5 5 5 0 YjcQ protein PDEase_I PF00233.19 EFC47848.1 - 6.1e-68 229.1 3.2 6.1e-68 229.1 3.2 3.6 3 0 0 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EFC47848.1 - 0.046 14.0 0.5 0.19 12.0 0.0 2.3 2 0 0 2 2 2 0 HD domain DUF4512 PF14975.6 EFC47848.1 - 0.62 10.9 0.0 0.62 10.9 0.0 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4512) DnaJ PF00226.31 EFC47849.1 - 1.1e-18 67.1 8.8 1.1e-18 67.1 8.8 2.9 3 0 0 3 3 3 1 DnaJ domain TPR_2 PF07719.17 EFC47849.1 - 4.4e-11 42.0 15.1 0.024 14.7 0.1 7.3 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47849.1 - 1.3e-10 40.6 1.0 1.3 9.0 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47849.1 - 3.3e-08 33.1 9.0 0.038 14.2 0.0 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC47849.1 - 2.1e-07 31.3 5.6 0.01 16.3 0.5 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47849.1 - 2.1e-06 28.3 2.9 0.06 14.0 0.2 4.6 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC47849.1 - 1.4e-05 25.2 0.0 0.018 15.2 0.0 3.6 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47849.1 - 1.7e-05 24.4 0.3 0.0099 15.5 0.3 3.8 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.6 EFC47849.1 - 0.00014 22.4 0.7 20 6.4 0.0 5.5 5 1 0 6 6 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC47849.1 - 0.00035 20.7 13.3 0.0046 17.2 0.6 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 EFC47849.1 - 0.00099 19.4 10.2 4.3 7.7 0.3 5.3 5 1 1 6 6 5 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC47849.1 - 0.0043 17.1 11.0 0.58 10.3 0.1 5.4 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 EFC47849.1 - 0.0068 16.4 5.2 0.65 10.2 0.2 5.5 6 1 0 6 6 6 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EFC47849.1 - 0.41 11.1 5.4 56 4.2 0.1 4.3 2 2 3 5 5 5 0 Alkyl sulfatase dimerisation Phage_int_SAM_5 PF13102.6 EFC47849.1 - 0.48 10.8 0.1 0.48 10.8 0.1 3.3 3 0 0 3 3 3 0 Phage integrase SAM-like domain HEPN PF05168.14 EFC47849.1 - 0.61 10.2 9.4 0.88 9.7 0.1 3.8 3 1 0 3 3 3 0 HEPN domain Aminotran_1_2 PF00155.21 EFC47850.1 - 6.7e-83 278.8 0.0 7.9e-83 278.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II ILEI PF15711.5 EFC47850.1 - 0.098 13.2 0.0 0.97 10.0 0.0 2.5 2 0 0 2 2 2 0 Interleukin-like EMT inducer DUF4116 PF13475.6 EFC47851.1 - 7.1e-67 221.0 3.9 1.9e-13 49.9 0.0 7.7 4 2 4 9 9 9 8 Domain of unknown function (DUF4116) HTH_8 PF02954.19 EFC47851.1 - 0.14 12.0 0.4 83 3.1 0.0 4.2 5 0 0 5 5 5 0 Bacterial regulatory protein, Fis family MCM PF00493.23 EFC47852.1 - 4.6e-85 284.3 0.0 6.9e-85 283.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC47852.1 - 8.7e-27 93.5 0.4 4.4e-25 88.0 0.0 2.4 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 EFC47852.1 - 2.7e-25 88.6 0.2 5.4e-25 87.6 0.2 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFC47852.1 - 2.6e-06 27.9 0.9 1.3e-05 25.7 0.0 2.5 3 0 0 3 3 3 1 MCM N-terminal domain AAA_5 PF07728.14 EFC47852.1 - 0.00013 22.0 0.0 0.0017 18.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 EFC47852.1 - 0.00083 18.8 0.0 0.006 16.0 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 EFC47852.1 - 0.0029 18.0 0.0 0.0063 16.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC47852.1 - 0.027 14.2 0.1 0.079 12.7 0.1 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_lid_2 PF17863.1 EFC47852.1 - 0.064 13.1 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA lid domain TetR_C_16 PF17920.1 EFC47853.1 - 0.11 12.7 0.1 26 5.1 0.0 2.7 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Suv3_N PF18114.1 EFC47853.1 - 0.48 10.6 2.7 6.7 6.9 0.0 2.8 3 0 0 3 3 3 0 Suv3 helical N-terminal domain MSP7_C PF12948.7 EFC47853.1 - 0.57 10.8 3.5 3 8.5 0.1 3.6 3 1 3 6 6 6 0 MSP7-like protein C-terminal domain CPSF100_C PF13299.6 EFC47853.1 - 3.2 7.9 7.1 3.6 7.7 0.2 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RGS PF00615.19 EFC47854.1 - 3.2e-11 43.5 1.8 3.2e-11 43.5 1.8 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF3053 PF11254.8 EFC47856.1 - 0.016 14.8 0.6 0.02 14.5 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) DUF1477 PF07346.11 EFC47856.1 - 0.047 14.0 0.2 0.1 12.8 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1477) Anti-adapt_IraP PF10796.9 EFC47856.1 - 0.18 12.4 4.8 0.18 12.4 0.9 2.5 2 1 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein RWP-RK PF02042.15 EFC47857.1 - 7.5e-07 29.0 0.2 1.5e-06 28.1 0.2 1.5 1 0 0 1 1 1 1 RWP-RK domain Pinin_SDK_memA PF04696.13 EFC47857.1 - 0.21 11.6 2.3 0.39 10.8 1.9 1.6 1 1 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF4911 PF16256.5 EFC47858.1 - 0.019 14.9 0.2 0.045 13.7 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) WD40 PF00400.32 EFC47859.1 - 8.9e-05 23.2 0.2 0.008 17.0 0.1 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat Pex24p PF06398.11 EFC47861.1 - 0.043 12.8 0.1 0.053 12.5 0.1 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Met_10 PF02475.16 EFC47862.1 - 4.9e-67 225.6 1.8 7.1e-67 225.0 1.8 1.2 1 0 0 1 1 1 1 Met-10+ like-protein TRM PF02005.16 EFC47862.1 - 2.1e-06 27.2 0.1 2.9e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase MTS PF05175.14 EFC47862.1 - 0.00016 21.3 0.0 0.00029 20.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFC47862.1 - 0.0026 17.2 0.0 0.0043 16.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 EFC47862.1 - 0.089 12.4 0.3 0.15 11.7 0.3 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.6 EFC47862.1 - 0.091 12.6 0.0 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Arm PF00514.23 EFC47863.1 - 4.7e-93 302.7 17.7 3.1e-13 49.3 0.5 10.0 10 0 0 10 10 10 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC47863.1 - 3.9e-27 94.3 0.1 2.7e-07 30.9 0.0 5.5 4 1 1 5 5 5 5 HEAT-like repeat Arm_3 PF16186.5 EFC47863.1 - 2e-21 75.3 2.4 4.6e-20 70.9 0.8 2.4 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_2 PF13646.6 EFC47863.1 - 5.4e-17 62.0 0.1 4.6e-05 23.7 0.0 5.5 3 2 4 7 7 7 5 HEAT repeats HEAT PF02985.22 EFC47863.1 - 1.9e-13 49.4 1.5 0.092 13.1 0.0 7.7 9 0 0 9 9 8 3 HEAT repeat IBB PF01749.20 EFC47863.1 - 9.8e-09 35.5 1.9 2.5e-08 34.2 1.9 1.7 1 0 0 1 1 1 1 Importin beta binding domain Arm_2 PF04826.13 EFC47863.1 - 3.4e-07 30.0 0.0 0.00066 19.2 0.0 3.2 3 0 0 3 3 3 1 Armadillo-like V-ATPase_H_C PF11698.8 EFC47863.1 - 3.7e-06 27.0 0.0 0.0078 16.3 0.0 4.3 3 2 1 4 4 4 2 V-ATPase subunit H Adaptin_N PF01602.20 EFC47863.1 - 1.8e-05 23.5 0.5 0.002 16.8 0.0 3.3 1 1 2 3 3 3 1 Adaptin N terminal region CTNNBL PF08216.11 EFC47863.1 - 0.00023 21.3 0.0 3.9 7.7 0.0 4.3 4 1 1 5 5 5 1 Catenin-beta-like, Arm-motif containing nuclear RICTOR_V PF14668.6 EFC47863.1 - 0.00027 21.1 2.8 2.7 8.3 0.1 5.2 4 2 2 6 6 6 2 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 EFC47863.1 - 0.0011 18.9 1.9 3.5 7.7 0.4 3.9 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain Cnd1 PF12717.7 EFC47863.1 - 0.011 15.8 0.0 0.47 10.5 0.0 3.2 1 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 EFC47863.1 - 0.032 14.2 0.2 0.18 11.7 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) HEAT_PBS PF03130.16 EFC47863.1 - 1.4 9.8 2.8 28 5.7 0.0 4.3 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat DSPc PF00782.20 EFC47864.1 - 1.1e-31 109.4 0.2 1.2e-31 109.3 0.2 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC47864.1 - 1.5e-05 24.7 0.0 1.7e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 EFC47864.1 - 0.0041 17.4 0.1 0.0047 17.2 0.1 1.2 1 0 0 1 1 1 1 Rit1 DUSP-like domain CDKN3 PF05706.12 EFC47864.1 - 0.013 15.2 0.1 0.014 15.0 0.1 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 EFC47864.1 - 0.033 14.3 0.0 0.048 13.8 0.0 1.5 1 1 0 1 1 1 0 Inositol hexakisphosphate Arm PF00514.23 EFC47865.1 - 3.5e-67 220.6 6.5 6.7e-09 35.5 0.0 9.5 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 EFC47865.1 - 4e-19 68.7 0.0 1e-06 29.1 0.0 6.7 5 1 1 6 6 6 4 HEAT-like repeat Arm_3 PF16186.5 EFC47865.1 - 1.1e-17 63.3 5.1 6e-16 57.8 0.8 3.6 4 1 1 5 5 5 1 Atypical Arm repeat HEAT_2 PF13646.6 EFC47865.1 - 4.6e-15 55.8 0.0 2.2e-05 24.7 0.0 4.1 2 1 2 4 4 4 4 HEAT repeats HEAT PF02985.22 EFC47865.1 - 8e-11 41.2 0.1 0.1 12.9 0.0 6.2 6 0 0 6 6 6 1 HEAT repeat Arm_2 PF04826.13 EFC47865.1 - 1.9e-06 27.5 0.2 0.0055 16.2 0.0 3.9 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 EFC47865.1 - 1e-05 25.6 0.2 0.0097 16.0 0.0 4.2 5 1 1 6 6 6 1 V-ATPase subunit H RICTOR_V PF14668.6 EFC47865.1 - 4.3e-05 23.7 1.7 6.9 7.0 0.2 4.5 3 2 2 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 NopRA1 PF16201.5 EFC47865.1 - 0.00014 21.5 0.1 2.2 7.8 0.0 4.1 2 2 2 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 Adaptin_N PF01602.20 EFC47865.1 - 0.00038 19.1 0.0 0.0042 15.7 0.0 2.3 1 1 3 4 4 4 2 Adaptin N terminal region KAP PF05804.12 EFC47865.1 - 0.01 14.1 0.0 0.018 13.2 0.0 1.5 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) DCB PF16213.5 EFC47865.1 - 0.026 14.2 0.1 0.14 11.8 0.0 2.4 2 1 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 OST_P2 PF18235.1 EFC47865.1 - 0.06 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Oligosaccharyltransferase Peripheral 2 domain CTNNBL PF08216.11 EFC47865.1 - 0.095 12.9 8.9 0.2 11.8 0.1 4.9 5 2 1 6 6 6 0 Catenin-beta-like, Arm-motif containing nuclear LRR_6 PF13516.6 EFC47867.1 - 1.1e-67 218.4 7.2 9.4e-06 25.3 0.0 13.1 13 0 0 13 13 13 11 Leucine Rich repeat LRR_8 PF13855.6 EFC47867.1 - 2.2e-37 126.6 26.9 1.1e-08 34.7 0.5 6.2 3 2 6 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EFC47867.1 - 3.3e-32 110.0 13.9 0.00011 22.6 0.2 6.8 3 2 0 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC47867.1 - 6e-18 62.6 1.3 7.4 7.6 0.0 11.4 13 0 0 13 13 11 2 Leucine Rich Repeat DUF5490 PF17593.2 EFC47867.1 - 8.3e-05 22.5 8.4 22 5.2 0.0 8.7 7 4 4 11 11 11 0 Family of unknown function (DUF5490) VirE_N PF08800.10 EFC47867.1 - 0.00067 19.8 0.1 2.7 8.1 0.0 3.4 2 1 1 3 3 3 1 VirE N-terminal domain ApoB100_C PF12491.8 EFC47867.1 - 0.0011 18.8 21.0 6.5 6.8 0.1 9.0 4 3 6 10 10 10 1 Apolipoprotein B100 C terminal Apo-VLDL-II PF05418.11 EFC47867.1 - 0.008 16.7 1.7 1.9e+02 2.7 0.0 5.6 3 1 4 7 7 7 0 Apovitellenin I (Apo-VLDL-II) Beta_helix PF13229.6 EFC47867.1 - 0.015 15.2 14.8 0.067 13.0 5.9 3.3 2 1 1 3 3 3 0 Right handed beta helix region AlphaC_N PF08829.10 EFC47867.1 - 0.21 11.6 3.8 3.9 7.5 0.1 3.6 2 1 2 5 5 5 0 Alpha C protein N terminal UPF0193 PF05250.11 EFC47867.1 - 0.8 9.5 19.2 0.36 10.6 0.5 5.0 1 1 4 6 6 6 0 Uncharacterised protein family (UPF0193) DUF2013 PF09431.10 EFC47868.1 - 1.2e-05 25.5 1.7 1.2e-05 25.5 1.7 2.8 3 1 0 3 3 3 2 Protein of unknown function (DUF2013) PIN_6 PF17146.4 EFC47870.1 - 1.1e-28 99.5 0.4 4.1e-28 97.7 0.0 2.0 2 0 0 2 2 2 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 EFC47870.1 - 1.8e-23 82.5 1.3 3.5e-23 81.6 1.3 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 EFC47870.1 - 0.018 14.7 5.5 0.04 13.6 5.5 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DZR PF12773.7 EFC47870.1 - 0.038 14.0 1.1 0.081 13.0 1.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-NADH-PPase PF09297.11 EFC47870.1 - 0.077 12.7 0.2 0.077 12.7 0.2 1.9 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Cytomega_UL84 PF06284.11 EFC47870.1 - 0.14 10.6 3.8 0.23 9.9 3.8 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ribosomal_60s PF00428.19 EFC47870.1 - 5.3 7.7 8.9 14 6.4 7.3 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein WRNPLPNID PF15017.6 EFC47870.1 - 5.4 8.0 15.8 0.15 12.9 7.2 2.6 3 0 0 3 3 3 0 Putative WW-binding domain and destruction box RNA_lig_T4_1 PF09511.10 EFC47871.1 - 7.3e-28 97.9 2.8 3e-27 95.9 0.0 2.5 2 0 0 2 2 2 1 RNA ligase DLP_helical PF18709.1 EFC47871.1 - 6e-05 22.4 4.0 0.14 11.3 1.8 2.2 1 1 1 2 2 2 2 Dynamin-like helical domain NPV_P10 PF05531.12 EFC47871.1 - 0.029 14.8 4.1 0.36 11.3 0.2 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF5513 PF17632.2 EFC47871.1 - 0.37 11.3 4.3 0.1 13.0 0.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5513) Penicil_amidase PF01804.18 EFC47872.1 - 2.8e-91 307.5 0.3 3.6e-91 307.2 0.3 1.1 1 0 0 1 1 1 1 Penicillin amidase Phage_T4_gp36 PF03903.13 EFC47872.1 - 4.9e-05 23.3 2.0 7.1e-05 22.8 0.4 2.1 2 0 0 2 2 2 1 Phage T4 tail fibre ADP_ribosyl_GH PF03747.14 EFC47873.1 - 4.4e-40 138.2 0.1 6e-40 137.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase BORCS6 PF10157.9 EFC47874.1 - 0.0058 16.9 0.3 0.0082 16.4 0.3 1.3 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 Endonuc-PvuII PF09225.10 EFC47876.1 - 0.022 14.5 0.5 0.027 14.2 0.5 1.1 1 0 0 1 1 1 0 Restriction endonuclease PvuII DHO_dh PF01180.21 EFC47877.1 - 1.4e-36 126.3 0.1 2.3e-36 125.5 0.1 1.4 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Fer4_20 PF14691.6 EFC47877.1 - 8.6e-33 112.5 1.1 8.6e-33 112.5 1.1 2.9 2 1 1 3 3 3 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Fer4_21 PF14697.6 EFC47877.1 - 6.9e-23 80.5 12.6 6.9e-23 80.5 12.6 3.0 2 1 0 2 2 2 1 4Fe-4S dicluster domain Pyr_redox_2 PF07992.14 EFC47877.1 - 5.3e-14 52.1 0.0 1.3e-13 50.9 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC47877.1 - 9.5e-09 34.9 0.1 0.0087 15.3 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 EFC47877.1 - 3.7e-08 33.8 22.0 3.7e-07 30.6 8.4 3.4 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 EFC47877.1 - 6.2e-08 32.4 25.5 9.8e-05 22.3 2.5 4.2 3 0 0 3 3 3 2 4Fe-4S binding domain NAD_binding_8 PF13450.6 EFC47877.1 - 1.8e-07 31.3 0.0 4.6e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Fer4_10 PF13237.6 EFC47877.1 - 2e-07 31.0 27.1 1.3e-06 28.4 10.7 3.0 2 2 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 EFC47877.1 - 8.8e-05 22.4 30.8 0.024 14.7 3.2 4.4 4 0 0 4 4 3 3 4Fe-4S binding domain Fer4_9 PF13187.6 EFC47877.1 - 0.00011 22.3 10.8 0.00011 22.3 10.8 2.9 3 0 0 3 3 2 2 4Fe-4S dicluster domain Dus PF01207.17 EFC47877.1 - 0.00042 19.5 0.1 0.0019 17.4 0.1 1.9 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) FAD_oxidored PF12831.7 EFC47877.1 - 0.00062 19.2 0.0 0.033 13.5 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Fer4 PF00037.27 EFC47877.1 - 0.0016 18.1 3.3 0.0016 18.1 3.3 4.6 5 0 0 5 5 5 2 4Fe-4S binding domain FAD_binding_2 PF00890.24 EFC47877.1 - 0.0023 17.1 0.3 0.054 12.6 0.1 2.5 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 EFC47877.1 - 0.018 14.6 0.0 0.038 13.6 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 EFC47877.1 - 0.034 14.7 0.1 0.85 10.2 0.0 2.8 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_8 PF13183.6 EFC47877.1 - 0.041 14.3 23.8 0.086 13.3 2.2 4.1 3 1 1 4 4 4 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 EFC47877.1 - 0.042 14.4 22.5 0.12 12.9 1.0 3.9 4 0 0 4 4 3 0 4Fe-4S dicluster domain Thi4 PF01946.17 EFC47877.1 - 0.05 12.8 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Shikimate_DH PF01488.20 EFC47877.1 - 0.13 12.3 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Fer4_18 PF13746.6 EFC47877.1 - 0.59 10.3 19.9 0.33 11.2 0.5 4.0 3 1 1 4 4 4 0 4Fe-4S dicluster domain HI0933_like PF03486.14 EFC47877.1 - 0.62 8.7 1.7 1.9 7.1 0.2 2.4 3 0 0 3 3 3 0 HI0933-like protein Fer4_16 PF13484.6 EFC47877.1 - 1.1 10.3 23.5 1.1 10.2 3.2 4.6 3 1 0 4 4 4 0 4Fe-4S double cluster binding domain TLD PF07534.16 EFC47878.1 - 5.6e-18 65.5 0.7 1.2e-17 64.4 0.7 1.6 1 0 0 1 1 1 1 TLD BTB_2 PF02214.22 EFC47878.1 - 7.4e-12 45.5 0.1 3.8e-11 43.2 0.1 2.1 1 1 0 1 1 1 1 BTB/POZ domain DUF2070 PF09843.9 EFC47879.1 - 3.7 5.7 13.4 7.8 4.6 13.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FKBP_C PF00254.28 EFC47880.1 - 1.7e-36 124.4 0.4 1.3e-31 108.8 0.0 2.7 2 1 1 3 3 3 2 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 EFC47880.1 - 1.7e-12 46.6 2.6 0.00062 19.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC47880.1 - 1.5e-10 40.3 1.6 0.033 14.3 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47880.1 - 6e-09 35.4 3.3 8.7e-06 25.6 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47880.1 - 1.9e-07 31.3 1.1 0.045 14.0 0.1 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47880.1 - 2.9e-07 30.1 1.5 0.0063 16.2 0.2 2.8 2 1 0 2 2 2 2 TPR repeat TPR_7 PF13176.6 EFC47880.1 - 8.4e-06 25.5 0.8 0.063 13.3 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC47880.1 - 0.0011 19.5 1.6 0.022 15.4 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC47880.1 - 0.0093 16.2 0.7 0.035 14.3 0.6 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC47880.1 - 0.016 15.7 0.1 0.19 12.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 EFC47880.1 - 0.019 15.4 2.5 0.067 13.6 0.2 2.6 2 1 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_9 PF13371.6 EFC47880.1 - 0.022 14.9 0.1 0.096 12.8 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Mak10 PF04112.13 EFC47881.1 - 9.6e-30 103.3 1.1 5.5e-29 100.8 0.1 2.5 2 1 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase ProRS-C_1 PF09180.11 EFC47882.1 - 3.2e-22 78.5 0.1 8.6e-22 77.1 0.1 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 EFC47882.1 - 1.9e-20 73.6 0.0 3.3e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 EFC47882.1 - 1.1e-17 63.9 0.0 2.7e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain TPX2 PF06886.11 EFC47882.1 - 1.9 8.8 9.1 6.5 7.1 9.1 1.9 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Surp PF01805.20 EFC47883.1 - 2.3e-22 78.8 1.4 4.6e-15 55.4 0.3 2.7 2 0 0 2 2 2 2 Surp module PRP21_like_P PF12230.8 EFC47883.1 - 3.5e-17 63.0 20.1 3.5e-17 63.0 20.1 2.3 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein PAS_3 PF08447.12 EFC47884.1 - 2.8e-07 30.7 0.0 5.8e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 PAS fold ZapB PF06005.12 EFC47884.1 - 0.0025 18.2 0.4 0.0025 18.2 0.4 3.5 4 1 0 4 4 4 1 Cell division protein ZapB Lzipper-MIP1 PF14389.6 EFC47884.1 - 0.0039 17.5 1.1 0.0087 16.3 0.1 2.2 3 0 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 TMF_TATA_bd PF12325.8 EFC47884.1 - 0.0048 17.1 0.2 0.0048 17.1 0.2 2.5 3 0 0 3 3 3 1 TATA element modulatory factor 1 TATA binding PAS_8 PF13188.7 EFC47884.1 - 0.0058 16.6 0.0 0.015 15.3 0.0 1.7 1 1 0 1 1 1 1 PAS domain PAS_9 PF13426.7 EFC47884.1 - 0.0096 16.2 0.1 0.055 13.7 0.0 2.3 2 0 0 2 2 2 1 PAS domain Seryl_tRNA_N PF02403.22 EFC47884.1 - 0.055 13.7 1.0 0.055 13.7 1.0 2.1 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TMF_DNA_bd PF12329.8 EFC47884.1 - 0.082 12.9 1.0 0.52 10.4 0.1 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding JIP_LZII PF16471.5 EFC47884.1 - 0.12 12.6 0.1 0.27 11.5 0.1 1.6 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II Spc24 PF08286.11 EFC47884.1 - 0.12 12.6 0.1 0.12 12.6 0.1 2.9 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 LRR_8 PF13855.6 EFC47885.1 - 5.4e-21 74.1 13.0 3.9e-09 36.1 0.4 3.6 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC47885.1 - 2.2e-17 62.8 12.5 3.3e-06 27.3 0.2 4.3 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC47885.1 - 1.8e-15 55.6 0.2 0.0038 17.1 0.0 4.6 4 0 0 4 4 4 4 Leucine Rich repeat LRR_1 PF00560.33 EFC47885.1 - 1.1e-07 31.4 0.8 4.7 8.2 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich Repeat RHH_3 PF12651.7 EFC47885.1 - 0.00017 21.5 0.0 1.4 8.9 0.0 4.1 1 1 3 4 4 4 1 Ribbon-helix-helix domain Spidroin_N PF16763.5 EFC47885.1 - 0.0032 17.5 2.6 18 5.3 0.0 4.4 1 1 3 4 4 4 0 Major ampullate spidroin 1, spider silk protein 1, N-term UPF0193 PF05250.11 EFC47885.1 - 0.089 12.6 2.2 7.9 6.2 0.1 2.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0193) Lipoprotein_3 PF00938.17 EFC47885.1 - 0.1 12.8 0.8 0.31 11.3 0.8 1.8 1 0 0 1 1 1 0 Lipoprotein F-box-like PF12937.7 EFC47885.1 - 0.2 11.6 0.2 0.33 10.9 0.2 1.3 1 0 0 1 1 1 0 F-box-like Homeodomain PF00046.29 EFC47885.1 - 0.23 11.3 2.1 0.31 10.9 0.3 2.2 2 0 0 2 2 2 0 Homeodomain EF-hand_1 PF00036.32 EFC47888.1 - 4.1e-30 101.1 11.0 1.5e-06 27.4 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFC47888.1 - 3.4e-28 97.9 7.0 6.6e-13 48.9 0.4 2.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC47888.1 - 1.7e-24 83.6 6.7 1.2e-05 24.9 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFC47888.1 - 5.7e-22 76.2 10.4 1.3e-05 24.5 0.2 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 EFC47888.1 - 4e-17 61.8 9.1 0.00072 19.3 0.0 4.6 4 1 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC47888.1 - 2e-08 34.5 0.0 0.0054 17.0 0.0 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC47888.1 - 1.5e-06 28.1 3.3 0.12 12.4 0.3 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 EFC47888.1 - 0.00024 21.4 0.1 0.2 12.0 0.0 3.1 2 1 1 3 3 3 1 EF-hand domain Sigma54_CBD PF04963.13 EFC47888.1 - 0.072 12.9 1.1 2.7 7.8 0.0 2.5 1 1 1 3 3 3 0 Sigma-54 factor, core binding domain Dockerin_1 PF00404.18 EFC47888.1 - 0.18 12.0 8.0 13 6.1 1.6 3.7 1 1 3 4 4 4 0 Dockerin type I domain Excalibur PF05901.11 EFC47888.1 - 3.6 8.3 0.0 3.6 8.3 0.0 3.2 4 0 0 4 4 4 0 Excalibur calcium-binding domain MKT1_N PF12247.8 EFC47889.1 - 0.067 13.6 0.1 0.21 12.0 0.1 1.8 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication PBP_like PF12727.7 EFC47889.1 - 0.08 12.1 0.5 0.17 11.0 0.1 1.8 2 0 0 2 2 2 0 PBP superfamily domain Actin PF00022.19 EFC47890.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin Rhodanese PF00581.20 EFC47891.1 - 6.8e-08 33.0 0.0 9.4e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain DrsE_2 PF13686.6 EFC47891.1 - 0.059 13.3 0.0 0.093 12.6 0.0 1.3 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family L-fibroin PF05849.11 EFC47891.1 - 0.077 12.3 0.4 0.089 12.1 0.4 1.1 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) C2 PF00168.30 EFC47891.1 - 0.11 12.8 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 C2 domain NTP_transferase PF00483.23 EFC47892.1 - 6.1e-13 48.9 0.0 4.9e-08 32.9 0.0 2.3 2 1 0 2 2 2 2 Nucleotidyl transferase DUF1394 PF07159.12 EFC47893.1 - 3.1e-05 23.4 2.2 3.6e-05 23.2 0.5 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1394) ABC2_membrane PF01061.24 EFC47894.1 - 1.1e-48 165.5 26.3 1.5e-48 165.0 26.3 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC47894.1 - 9.5e-26 90.9 0.1 2.1e-25 89.8 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 EFC47894.1 - 1.4e-08 34.9 0.0 0.0024 17.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 EFC47894.1 - 2.1e-08 33.7 18.1 3.2e-08 33.1 18.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein RsgA_GTPase PF03193.16 EFC47894.1 - 2e-05 24.6 0.0 3.7e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFC47894.1 - 0.0023 18.3 0.0 0.0038 17.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EFC47894.1 - 0.021 14.5 0.1 0.034 13.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 EFC47894.1 - 0.028 13.7 0.0 0.057 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_35 PF14516.6 EFC47894.1 - 0.044 12.6 0.0 0.072 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain IstB_IS21 PF01695.17 EFC47894.1 - 0.053 13.3 0.0 0.37 10.5 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein T2SSE PF00437.20 EFC47894.1 - 0.054 12.5 0.0 0.13 11.3 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein SMC_N PF02463.19 EFC47894.1 - 0.065 12.7 0.0 2.6 7.4 0.0 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFC47894.1 - 0.072 13.4 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFC47894.1 - 0.086 12.7 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 EFC47894.1 - 0.11 13.0 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC47894.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 EFC47894.1 - 0.13 12.4 0.2 0.29 11.2 0.2 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_23 PF13476.6 EFC47894.1 - 0.19 12.2 0.1 0.4 11.2 0.0 1.6 2 0 0 2 2 1 0 AAA domain ABC2_membrane_2 PF12679.7 EFC47894.1 - 5.6 6.1 13.4 22 4.2 13.4 1.9 1 1 0 1 1 1 0 ABC-2 family transporter protein RhoGEF PF00621.20 EFC47896.1 - 1.2e-42 146.2 4.7 1.2e-42 146.2 4.7 2.6 3 0 0 3 3 3 1 RhoGEF domain DUF4407 PF14362.6 EFC47896.1 - 2.1 7.6 6.3 5.3 6.3 6.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Xpo1 PF08389.12 EFC47896.1 - 4.5 7.3 7.8 5.5 7.0 3.1 2.8 2 0 0 2 2 2 0 Exportin 1-like protein TM2 PF05154.16 EFC47897.1 - 9.3e-14 51.5 1.5 9.3e-14 51.5 1.5 1.8 2 0 0 2 2 2 1 TM2 domain PROL5-SMR PF15621.6 EFC47898.1 - 0.0023 18.4 0.1 0.0042 17.6 0.1 1.5 1 0 0 1 1 1 1 Proline-rich submaxillary gland androgen-regulated family BPL_LplA_LipB PF03099.19 EFC47899.1 - 9.3e-05 22.3 0.0 0.00051 20.0 0.0 2.2 2 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family DUF3394 PF11874.8 EFC47899.1 - 0.096 12.4 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) C2 PF00168.30 EFC47900.1 - 4.9e-16 58.9 0.1 9.6e-16 58.0 0.1 1.5 1 0 0 1 1 1 1 C2 domain PEN-2 PF10251.9 EFC47901.1 - 0.02 15.3 0.6 0.026 14.9 0.6 1.2 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase ESSS PF10183.9 EFC47901.1 - 0.039 14.2 1.2 0.24 11.6 0.2 2.0 1 1 1 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Pox_A14 PF05767.12 EFC47901.1 - 0.044 13.9 1.8 0.057 13.6 1.8 1.2 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 CrgA PF06781.12 EFC47901.1 - 0.087 12.9 0.7 0.18 11.9 0.7 1.6 1 1 0 1 1 1 0 Cell division protein CrgA PLDc PF00614.22 EFC47902.1 - 3.9e-18 64.8 4.2 6.9e-09 35.5 0.1 2.9 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 EFC47902.1 - 2.8e-17 62.8 4.1 1.1e-09 38.3 2.0 3.6 2 1 0 2 2 2 2 PLD-like domain EF-hand_7 PF13499.6 EFC47902.1 - 0.075 13.5 1.2 0.39 11.2 0.1 2.8 3 0 0 3 3 3 0 EF-hand domain pair zf-B_box PF00643.24 EFC47904.1 - 1.6e-06 28.2 6.0 1.6e-06 28.2 6.0 3.1 3 1 0 3 3 3 1 B-box zinc finger Tweety PF04906.13 EFC47904.1 - 0.0041 15.8 1.3 0.0041 15.8 1.3 1.7 2 0 0 2 2 2 1 Tweety SPRY PF00622.28 EFC47904.1 - 0.022 14.8 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 SPRY domain Neuralized PF07177.12 EFC47904.1 - 0.05 13.6 0.0 0.14 12.2 0.0 1.8 1 1 0 1 1 1 0 Neuralized RelB_leu_zip PF16180.5 EFC47904.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 RelB leucine zipper Baculo_PEP_C PF04513.12 EFC47904.1 - 0.26 11.3 3.2 0.43 10.6 2.5 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus OrsD PF12013.8 EFC47904.1 - 3.1 8.3 11.8 1.1 9.7 2.2 2.9 2 1 1 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D DUF1664 PF07889.12 EFC47904.1 - 4.3 7.4 9.8 1.6 8.8 5.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ABC_tran PF00005.27 EFC47905.1 - 2.1e-25 89.8 0.0 2.9e-25 89.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC47905.1 - 1.6e-06 27.7 0.2 4.4e-06 26.3 0.2 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFC47905.1 - 4.6e-06 26.7 0.4 0.002 18.0 0.2 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFC47905.1 - 2.3e-05 25.0 0.1 3.3e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC47905.1 - 0.00015 21.7 0.1 0.00028 20.8 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC47905.1 - 0.00018 21.2 0.1 0.00038 20.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC47905.1 - 0.0016 18.8 0.0 0.0022 18.4 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EFC47905.1 - 0.0017 18.5 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EFC47905.1 - 0.0023 17.7 0.4 0.007 16.1 0.4 1.5 1 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 EFC47905.1 - 0.0037 17.7 0.1 0.015 15.7 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EFC47905.1 - 0.0039 16.8 0.1 0.0058 16.2 0.1 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EFC47905.1 - 0.0066 16.4 0.0 0.0096 15.8 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 EFC47905.1 - 0.0069 15.5 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 EFC47905.1 - 0.0072 16.6 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFC47905.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 EFC47905.1 - 0.02 15.3 0.0 0.036 14.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFC47905.1 - 0.021 14.6 0.0 0.038 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFC47905.1 - 0.027 14.4 0.0 0.62 10.0 0.0 2.2 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 EFC47905.1 - 0.03 14.2 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EFC47905.1 - 0.03 14.9 0.0 0.06 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 EFC47905.1 - 0.032 13.4 0.0 0.055 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ABC_ATPase PF09818.9 EFC47905.1 - 0.041 12.7 0.0 0.079 11.7 0.0 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_30 PF13604.6 EFC47905.1 - 0.046 13.4 0.0 0.086 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFC47905.1 - 0.06 13.4 0.0 0.31 11.1 0.0 2.1 1 1 0 2 2 2 0 AAA domain AAA_35 PF14516.6 EFC47905.1 - 0.061 12.2 0.0 0.085 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain MMR_HSR1 PF01926.23 EFC47905.1 - 0.068 13.2 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase ATP-synt_ab PF00006.25 EFC47905.1 - 0.1 12.2 0.1 0.16 11.6 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MobB PF03205.14 EFC47905.1 - 0.11 12.3 0.1 0.24 11.3 0.0 1.6 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_13 PF13166.6 EFC47905.1 - 0.12 10.9 2.0 0.81 8.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 EFC47905.1 - 0.17 12.2 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain LRR_6 PF13516.6 EFC47906.1 - 0.017 15.1 0.4 0.017 15.1 0.4 3.6 3 0 0 3 3 3 0 Leucine Rich repeat Defensin_3 PF08131.11 EFC47906.1 - 0.053 13.7 0.4 0.16 12.2 0.4 1.8 1 0 0 1 1 1 0 Defensin-like peptide family DUF2206 PF09971.9 EFC47908.1 - 1.2 7.8 9.2 0.92 8.2 8.0 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2206) Terpene_synth_C PF03936.16 EFC47909.1 - 8.3e-05 22.1 2.3 0.00026 20.4 1.2 2.3 1 1 1 2 2 2 1 Terpene synthase family, metal binding domain FA_hydroxylase PF04116.13 EFC47910.1 - 9.9e-19 68.0 17.7 1.2e-18 67.8 17.7 1.1 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily LPG_synthase_TM PF03706.13 EFC47912.1 - 0.0029 17.2 3.4 0.02 14.5 0.5 2.0 2 0 0 2 2 2 1 Lysylphosphatidylglycerol synthase TM region RSN1_TM PF13967.6 EFC47912.1 - 0.0072 16.1 7.2 0.04 13.7 0.6 2.2 2 0 0 2 2 2 2 Late exocytosis, associated with Golgi transport Phage_holin_3_6 PF07332.11 EFC47912.1 - 0.0084 16.1 1.6 0.26 11.3 0.8 2.1 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III COX14 PF14880.6 EFC47912.1 - 0.11 12.4 3.3 3.9 7.4 2.8 3.0 2 1 0 2 2 2 0 Cytochrome oxidase c assembly DUF3040 PF11239.8 EFC47912.1 - 0.21 11.9 0.2 0.21 11.9 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) DUF2681 PF10883.8 EFC47912.1 - 0.39 11.1 0.1 0.39 11.1 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2681) DUF2207 PF09972.9 EFC47912.1 - 0.74 8.5 6.3 1.4 7.6 6.3 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PRA1 PF03208.19 EFC47912.1 - 1.1 8.9 9.9 6.4 6.4 9.9 1.9 1 1 0 1 1 1 0 PRA1 family protein DUF3675 PF12428.8 EFC47912.1 - 3.9 8.1 9.2 8.6 6.9 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3675) Ninjurin PF04923.12 EFC47912.1 - 4.1 7.4 9.3 23 5.0 1.5 3.1 1 1 2 3 3 3 0 Ninjurin BOP1NT PF08145.12 EFC47913.1 - 0.059 13.3 0.3 0.079 12.9 0.3 1.2 1 0 0 1 1 1 0 BOP1NT (NUC169) domain SHOCT PF09851.9 EFC47914.1 - 1.6e-10 40.4 4.6 2.4e-10 39.8 4.6 1.3 1 0 0 1 1 1 1 Short C-terminal domain Arrestin_N PF00339.29 EFC47915.1 - 3.4e-13 49.9 0.0 2.2e-07 31.1 0.0 2.9 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 EFC47915.1 - 4.3e-13 49.9 0.4 2.1e-12 47.6 0.1 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 EFC47915.1 - 0.0074 15.5 0.1 6.2 5.9 0.0 3.1 2 1 1 3 3 3 3 Rgp1 MMR_HSR1 PF01926.23 EFC47916.1 - 2.4e-07 30.8 0.0 6.4e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 EFC47916.1 - 7.2e-05 22.4 0.3 0.11 12.1 0.1 2.4 2 0 0 2 2 2 2 Ras family Gtr1_RagA PF04670.12 EFC47916.1 - 0.002 17.5 1.5 0.078 12.3 1.1 2.3 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC47916.1 - 0.0078 16.4 0.1 0.11 12.7 0.0 2.6 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 EFC47916.1 - 0.012 14.9 0.1 0.028 13.7 0.1 1.7 1 1 0 1 1 1 0 Septin FeoB_N PF02421.18 EFC47916.1 - 0.026 14.1 0.1 0.062 12.8 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 EFC47916.1 - 0.028 14.1 0.3 0.07 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF1102 PF06510.11 EFC47917.1 - 0.099 12.8 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1102) CH PF00307.31 EFC47918.1 - 2.8e-16 59.7 2.2 2.2e-11 43.9 0.1 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain PH PF00169.29 EFC47918.1 - 4.8e-16 59.2 0.9 1.4e-15 57.7 0.1 2.3 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 EFC47918.1 - 0.0072 16.6 0.0 0.023 15.0 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 EFC47918.1 - 0.061 13.7 7.1 0.039 14.4 1.7 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain SBP_bac_3 PF00497.20 EFC47920.1 - 2.2e-10 40.4 0.0 1.5e-09 37.6 0.0 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 DUF948 PF06103.11 EFC47921.1 - 1.4 9.2 9.0 4.4 7.6 1.3 3.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) YvrJ PF12841.7 EFC47921.1 - 1.6 8.3 4.1 2.7 7.6 0.2 3.0 2 1 1 3 3 3 0 YvrJ protein family SAM_3 PF18016.1 EFC47923.1 - 0.13 12.1 0.1 1 9.2 0.0 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Trypan_PARP PF05887.11 EFC47924.1 - 1.6e-06 28.1 115.7 0.073 13.1 38.1 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) Clathrin PF00637.20 EFC47925.1 - 4e-13 49.4 51.9 0.0014 18.5 0.5 12.3 4 3 9 13 13 13 5 Region in Clathrin and VPS TPR_14 PF13428.6 EFC47925.1 - 0.00032 21.3 25.0 33 5.7 0.1 11.8 13 0 0 13 13 12 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47925.1 - 0.00078 20.0 8.8 24 5.7 0.0 7.8 9 0 0 9 9 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47925.1 - 0.0013 18.6 24.5 3.9 7.7 0.0 10.4 10 3 1 11 11 10 1 Tetratricopeptide repeat Virulence_fact PF13769.6 EFC47925.1 - 0.044 14.0 0.5 0.45 10.8 0.0 3.0 2 0 0 2 2 2 0 Virulence factor ANAPC4_WD40 PF12894.7 EFC47925.1 - 0.047 14.0 0.1 0.3 11.4 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DZR PF12773.7 EFC47925.1 - 0.094 12.8 13.3 0.24 11.5 13.3 1.7 1 0 0 1 1 1 0 Double zinc ribbon PPR PF01535.20 EFC47925.1 - 0.18 12.1 24.8 16 6.0 0.1 11.1 13 1 1 14 14 12 0 PPR repeat baeRF_family12 PF18856.1 EFC47925.1 - 0.38 11.3 4.6 0.19 12.3 1.2 2.4 2 0 0 2 2 1 0 Bacterial archaeo-eukaryotic release factor family 12 TPR_19 PF14559.6 EFC47925.1 - 0.48 11.0 20.4 10 6.7 0.0 8.3 7 2 2 9 9 9 0 Tetratricopeptide repeat zf-ribbon_3 PF13248.6 EFC47925.1 - 1.4 8.5 10.1 11 5.6 6.6 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Mad3_BUB1_I PF08311.12 EFC47925.1 - 2.2 8.2 28.1 0.47 10.5 0.7 7.3 7 2 0 7 7 7 0 Mad3/BUB1 homology region 1 UPF0547 PF10571.9 EFC47925.1 - 6 7.0 10.2 0.7 10.0 2.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-RING_4 PF14570.6 EFC47925.1 - 7 6.5 12.2 6.6 6.6 8.9 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Ank_4 PF13637.6 EFC47926.1 - 1.9e-24 85.7 1.7 7.3e-07 29.6 0.0 5.6 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC47926.1 - 7.5e-24 84.1 1.0 3.4e-13 50.0 0.2 3.8 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 EFC47926.1 - 3.3e-21 74.7 12.8 0.00015 22.0 0.0 6.9 6 1 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 EFC47926.1 - 2e-19 69.4 2.6 3.8e-07 30.2 0.4 5.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC47926.1 - 3.8e-16 57.5 3.0 0.0033 17.8 0.0 6.6 7 0 0 7 7 7 3 Ankyrin repeat CENP-B_dimeris PF09026.10 EFC47926.1 - 0.043 14.2 8.4 9.7 6.7 5.5 3.6 3 0 0 3 3 3 0 Centromere protein B dimerisation domain LRRC37AB_C PF14914.6 EFC47926.1 - 0.085 12.8 0.1 0.085 12.8 0.1 3.1 3 0 0 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain IGR PF09597.10 EFC47926.1 - 0.18 11.9 0.0 0.5 10.5 0.0 1.7 1 0 0 1 1 1 0 IGR protein motif MID_MedPIWI PF18296.1 EFC47926.1 - 0.34 10.6 12.2 2.3 8.0 4.5 2.3 2 0 0 2 2 2 0 MID domain of medPIWI NOA36 PF06524.12 EFC47926.1 - 1.6 8.0 20.8 0.17 11.2 6.8 2.3 2 0 0 2 2 2 0 NOA36 protein Presenilin PF01080.17 EFC47926.1 - 4.3 6.0 14.8 4.7 5.9 0.8 2.2 2 0 0 2 2 2 0 Presenilin TRM13 PF05206.14 EFC47926.1 - 4.8 6.6 8.6 0.38 10.3 0.4 2.7 3 0 0 3 3 3 0 Methyltransferase TRM13 Ada3 PF10198.9 EFC47927.1 - 1.7e-10 41.1 0.3 1.7e-10 41.1 0.3 4.7 6 1 0 6 6 6 1 Histone acetyltransferases subunit 3 Pyr_excise PF03013.14 EFC47927.1 - 0.11 12.5 5.4 2.8 7.9 0.7 3.4 3 0 0 3 3 3 0 Pyrimidine dimer DNA glycosylase TINF2_N PF14973.6 EFC47927.1 - 3.6 7.9 7.5 1.9 8.8 2.7 2.9 2 0 0 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus AAA_lid_2 PF17863.1 EFC47928.1 - 9.6e-05 22.1 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 AAA lid domain 2-oxoacid_dh PF00198.23 EFC47929.1 - 4.5e-63 212.8 0.2 6.1e-63 212.4 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFC47929.1 - 1.8e-16 59.7 0.1 3.6e-16 58.8 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EFC47929.1 - 0.00031 21.0 0.0 0.0019 18.5 0.0 2.4 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EFC47929.1 - 0.028 14.2 0.0 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 Biotin-lipoyl like DUF737 PF05300.11 EFC47929.1 - 0.2 12.0 2.2 0.74 10.1 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF737) SWI-SNF_Ssr4 PF08549.10 EFC47929.1 - 2.2 6.8 10.7 4.1 5.9 10.2 1.6 1 1 0 1 1 1 0 Fungal domain of unknown function (DUF1750) AAA_6 PF12774.7 EFC47930.1 - 2.5e-152 506.6 4.4 5.3e-152 505.5 0.0 3.5 4 0 0 4 4 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC47930.1 - 2.8e-118 395.5 16.6 2.8e-118 395.5 16.6 5.4 6 1 0 6 6 4 1 Dynein heavy chain, N-terminal region 2 Dynein_C PF18199.1 EFC47930.1 - 5e-113 377.4 0.0 5e-113 377.4 0.0 4.3 6 0 0 6 6 4 1 Dynein heavy chain C-terminal domain AAA_8 PF12780.7 EFC47930.1 - 8.5e-98 326.8 0.0 8.5e-98 326.8 0.0 3.9 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFC47930.1 - 5.5e-84 280.7 2.7 5.5e-84 280.7 2.7 5.0 8 0 0 8 8 2 2 ATP-binding dynein motor region AAA_7 PF12775.7 EFC47930.1 - 9.3e-80 266.4 1.0 2.4e-73 245.5 0.0 4.5 4 0 0 4 4 4 3 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC47930.1 - 5.3e-57 192.2 0.8 2.7e-56 189.9 0.1 2.6 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC47930.1 - 2.2e-43 147.1 1.5 1.8e-41 140.9 0.1 4.2 4 0 0 4 4 3 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 EFC47930.1 - 2.5e-42 145.2 10.0 5.5e-42 144.0 10.0 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 EFC47930.1 - 2.7e-36 124.5 1.1 2.1e-35 121.6 0.1 3.4 3 0 0 3 3 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFC47930.1 - 8.1e-26 90.7 0.0 7.6e-08 32.4 0.0 4.8 4 0 0 4 4 3 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFC47930.1 - 2.2e-21 75.9 0.1 1.7e-20 73.1 0.1 2.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 EFC47930.1 - 2.8e-10 40.6 0.0 0.067 13.5 0.0 5.5 4 0 0 4 4 4 3 AAA domain RNA_helicase PF00910.22 EFC47930.1 - 1.7e-08 34.8 0.6 0.18 12.2 0.0 5.9 5 0 0 5 5 5 1 RNA helicase AAA PF00004.29 EFC47930.1 - 1.2e-07 32.2 3.0 0.076 13.4 0.0 5.7 5 1 1 6 6 4 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC47930.1 - 2.6e-07 31.2 0.0 0.16 12.4 0.0 4.6 3 0 0 3 3 3 2 AAA ATPase domain AAA_33 PF13671.6 EFC47930.1 - 8.6e-07 29.2 0.0 0.27 11.4 0.0 4.6 4 0 0 4 4 4 1 AAA domain AAA_18 PF13238.6 EFC47930.1 - 1.8e-06 28.6 0.0 0.9 10.1 0.0 6.9 5 0 0 5 5 4 1 AAA domain Sigma54_activat PF00158.26 EFC47930.1 - 3.3e-05 23.6 0.1 0.5 10.0 0.0 3.2 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_25 PF13481.6 EFC47930.1 - 0.00038 20.1 0.2 0.45 10.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFC47930.1 - 0.00059 19.6 0.2 2.2 7.9 0.1 3.7 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 EFC47930.1 - 0.0011 18.2 1.6 0.28 10.2 0.0 3.3 4 0 0 4 4 4 1 Type II/IV secretion system protein DEAD PF00270.29 EFC47930.1 - 0.0012 18.6 0.0 3 7.6 0.0 3.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF815 PF05673.13 EFC47930.1 - 0.0035 16.5 0.5 0.2 10.8 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 EFC47930.1 - 0.0037 16.7 0.2 0.67 9.3 0.0 3.8 4 0 0 4 4 4 1 Magnesium chelatase, subunit ChlI DUF853 PF05872.12 EFC47930.1 - 0.0057 15.3 1.1 2.9 6.4 0.2 3.4 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF853) AAA_28 PF13521.6 EFC47930.1 - 0.022 15.0 0.1 18 5.5 0.0 4.4 4 0 0 4 4 4 0 AAA domain Trans_reg_C PF00486.28 EFC47930.1 - 0.042 13.9 0.0 6 7.0 0.1 3.3 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal Coatomer_b_Cpla PF14806.6 EFC47930.1 - 0.048 13.6 1.3 0.28 11.2 1.3 2.4 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform FtsK_SpoIIIE PF01580.18 EFC47930.1 - 0.049 13.0 0.1 4.7 6.5 0.0 3.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 EFC47930.1 - 0.07 12.0 5.3 1.8 7.4 0.0 4.2 4 0 0 4 4 4 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 EFC47930.1 - 0.13 12.0 0.1 14 5.4 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein TsaE PF02367.17 EFC47930.1 - 0.14 12.2 2.0 4.4 7.3 0.1 3.6 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 EFC47930.1 - 0.29 11.0 3.4 31 4.4 0.0 4.1 5 0 0 5 5 3 0 NACHT domain DUF2605 PF10792.9 EFC47930.1 - 0.81 9.6 3.6 1.7 8.6 0.9 3.1 2 0 0 2 2 1 0 Protein of unknown function (DUF2605) AAA_19 PF13245.6 EFC47930.1 - 1.2 9.5 4.9 47 4.3 0.1 4.3 5 0 0 5 5 3 0 AAA domain SRP54 PF00448.22 EFC47930.1 - 1.8 8.2 8.9 7.3 6.2 0.0 4.1 4 0 0 4 4 4 0 SRP54-type protein, GTPase domain GIT_CC PF16559.5 EFC47930.1 - 8.3 6.4 9.0 0.85 9.5 1.9 3.2 2 0 0 2 2 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor WW PF00397.26 EFC47931.1 - 6.7e-38 128.4 23.3 3.1e-14 52.7 1.5 3.5 3 0 0 3 3 3 3 WW domain C2 PF00168.30 EFC47931.1 - 5.5e-15 55.5 0.0 3.6e-13 49.7 0.0 2.5 2 0 0 2 2 2 1 C2 domain WD40 PF00400.32 EFC47932.1 - 8.9e-10 39.0 1.3 0.0023 18.7 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC47932.1 - 2.6e-07 30.8 0.1 0.018 15.4 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFC47932.1 - 2.2e-06 27.4 0.0 0.0033 17.0 0.0 1.6 1 1 1 2 2 2 2 PQQ-like domain Nup160 PF11715.8 EFC47932.1 - 3.2e-06 26.1 0.1 0.00052 18.8 0.0 2.4 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 EFC47932.1 - 0.0078 14.8 0.1 1.1 7.6 0.1 2.8 2 1 1 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 EFC47932.1 - 0.027 13.8 0.7 0.22 10.8 0.5 2.1 2 1 0 2 2 2 0 WD40-like domain GP67 PF17634.2 EFC47932.1 - 0.089 13.2 5.8 0.21 12.0 5.8 1.6 1 0 0 1 1 1 0 Gene product 67 DUF1768 PF08719.11 EFC47933.1 - 6.1e-52 176.1 0.9 7.9e-52 175.7 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Homeobox_KN PF05920.11 EFC47934.1 - 5.6e-17 61.4 0.1 1.7e-16 59.8 0.1 1.9 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC47934.1 - 1.1e-06 28.4 0.2 1.1e-06 28.4 0.2 2.6 2 0 0 2 2 2 1 Homeodomain PBC PF03792.13 EFC47934.1 - 2.7e-05 24.0 3.0 6.4e-05 22.8 1.8 2.1 1 1 0 1 1 1 1 PBC domain VWA PF00092.28 EFC47935.1 - 3.2e-10 40.5 2.6 3.2e-10 40.5 2.6 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC47935.1 - 1.9e-09 38.1 1.9 1.1e-08 35.7 0.1 2.9 3 0 0 3 3 3 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC47935.1 - 3.1e-09 37.0 0.0 8.7e-09 35.5 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF4476 PF14771.6 EFC47935.1 - 1.5e-08 34.8 4.5 8.3e-07 29.2 1.0 3.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4476) PhoLip_ATPase_N PF16209.5 EFC47935.1 - 0.084 12.6 0.7 0.39 10.4 0.2 2.4 2 0 0 2 2 2 0 Phospholipid-translocating ATPase N-terminal DSPc PF00782.20 EFC47936.1 - 1e-07 31.8 0.1 1.9e-07 31.0 0.1 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC47936.1 - 7.7e-06 25.6 0.0 9.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFC47936.1 - 8.3e-06 26.0 0.0 1.1e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFC47936.1 - 8e-05 22.7 0.0 9.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 EFC47936.1 - 0.01 15.4 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family MFS_1 PF07690.16 EFC47937.1 - 0.00013 21.1 5.2 0.00015 20.8 5.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily 2OG-FeII_Oxy_3 PF13640.6 EFC47938.1 - 1.5e-12 48.2 0.0 2.6e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFC47938.1 - 2.4e-05 23.6 0.0 3.6e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Poxvirus C4/C10 protein TLD PF07534.16 EFC47939.1 - 2.3e-17 63.5 0.0 4.8e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 TLD Dapper PF15268.6 EFC47939.1 - 1 8.1 35.1 1.3 7.7 35.1 1.1 1 0 0 1 1 1 0 Dapper Asp-B-Hydro_N PF05279.11 EFC47939.1 - 1.9 8.5 45.0 3.2 7.8 45.0 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region PSI PF01437.25 EFC47940.1 - 1.2e-06 29.0 6.8 1.2e-06 29.0 6.8 3.2 3 1 0 3 3 3 1 Plexin repeat 2OG-FeII_Oxy_2 PF13532.6 EFC47941.1 - 7.7e-13 49.1 0.9 2.8e-12 47.2 0.1 2.2 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Methyltransf_11 PF08241.12 EFC47941.1 - 9e-13 48.7 0.0 3.4e-12 46.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC47941.1 - 1.8e-09 38.2 0.0 4.8e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC47941.1 - 5.4e-06 26.3 0.0 2.1e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC47941.1 - 0.00026 20.9 0.0 0.00066 19.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC47941.1 - 0.0039 17.9 0.0 0.013 16.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC47941.1 - 0.0051 16.2 0.0 0.021 14.2 0.0 2.1 2 1 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EFC47941.1 - 0.019 13.9 0.3 0.12 11.3 0.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) NHL PF01436.21 EFC47942.1 - 1e-14 53.7 1.6 0.00099 19.0 0.2 5.2 5 0 0 5 5 5 3 NHL repeat EGF_2 PF07974.13 EFC47942.1 - 4.1e-05 23.8 12.5 8.8e-05 22.8 12.5 1.6 1 0 0 1 1 1 1 EGF-like domain DUF1191 PF06697.12 EFC47942.1 - 0.00024 20.9 0.1 0.00052 19.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1191) IL31 PF15209.6 EFC47942.1 - 0.11 12.2 6.9 0.028 14.2 1.2 2.3 1 1 1 2 2 2 0 Interleukin 31 Arylesterase PF01731.20 EFC47942.1 - 0.57 10.4 2.5 7.3 6.9 0.0 3.5 4 1 0 4 4 4 0 Arylesterase EGF_Tenascin PF18720.1 EFC47942.1 - 0.63 10.1 9.2 2.1 8.5 9.2 2.0 1 0 0 1 1 1 0 Tenascin EGF domain EGF_alliinase PF04863.13 EFC47942.1 - 8.9 6.8 11.1 38 4.8 11.1 2.1 1 1 0 1 1 1 0 Alliinase EGF-like domain DEP PF00610.21 EFC47943.1 - 3.1e-12 46.4 0.0 7.6e-12 45.1 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) 2-Hacid_dh_C PF02826.19 EFC47944.1 - 2e-54 183.6 0.0 2.8e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFC47944.1 - 5.8e-31 106.9 0.1 7.1e-31 106.6 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFC47944.1 - 1.2e-05 25.6 0.1 4.1e-05 23.8 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding_2 PF13380.6 EFC47944.1 - 0.0016 18.9 0.1 0.0046 17.4 0.0 1.8 2 1 0 2 2 2 1 CoA binding domain IlvN PF07991.12 EFC47944.1 - 0.039 13.5 0.1 0.077 12.6 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 EFC47944.1 - 0.16 12.1 2.0 0.22 11.6 0.2 2.3 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Wyosine_form PF08608.12 EFC47945.1 - 0.01 16.2 0.1 0.24 11.8 0.0 2.4 2 1 0 2 2 2 0 Wyosine base formation NRBF2 PF08961.10 EFC47945.1 - 0.027 14.1 0.8 0.027 14.1 0.8 1.6 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DivIC PF04977.15 EFC47945.1 - 0.095 12.5 14.7 0.55 10.0 0.1 3.2 2 1 1 3 3 3 0 Septum formation initiator DUF1192 PF06698.11 EFC47945.1 - 0.096 12.8 7.9 2.5 8.2 0.3 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) DUF2730 PF10805.8 EFC47945.1 - 0.18 11.9 8.4 2.3 8.3 5.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) SUV3_C PF12513.8 EFC47945.1 - 0.19 11.7 2.3 0.24 11.4 0.4 2.1 2 0 0 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal CENP-H PF05837.12 EFC47945.1 - 0.27 11.6 10.2 0.056 13.8 2.7 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) APG6_N PF17675.1 EFC47945.1 - 0.52 10.8 12.8 1.1 9.8 12.8 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region bZIP_1 PF00170.21 EFC47945.1 - 0.64 10.2 19.0 0.74 10.0 1.5 3.2 1 1 2 3 3 3 0 bZIP transcription factor SpoOE-like PF09388.10 EFC47945.1 - 1 9.3 9.5 0.38 10.7 0.3 3.3 3 0 0 3 3 3 0 Spo0E like sporulation regulatory protein DUF3450 PF11932.8 EFC47945.1 - 1.4 8.2 12.5 1.1 8.5 5.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Peptidase_S51 PF03575.17 EFC47946.1 - 1.7e-53 181.3 0.0 2e-53 181.1 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S51 S4_2 PF13275.6 EFC47946.1 - 0.0035 17.1 0.6 0.0066 16.2 0.1 1.7 2 0 0 2 2 2 1 S4 domain Lipocalin PF00061.23 EFC47946.1 - 0.055 13.7 0.1 0.099 12.8 0.1 1.5 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family DUF4116 PF13475.6 EFC47947.1 - 4e-09 36.0 5.4 4.2e-05 23.2 0.5 3.2 1 1 2 3 3 3 3 Domain of unknown function (DUF4116) SMI1_KNR4 PF09346.10 EFC47947.1 - 0.0052 17.2 0.3 0.013 15.9 0.3 1.9 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) Kelch_6 PF13964.6 EFC47948.1 - 1e-18 66.9 0.7 6.6e-09 35.8 0.0 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 EFC47948.1 - 3.4e-17 61.8 0.1 1.9e-08 33.7 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 EFC47948.1 - 9.9e-17 60.7 0.2 5.2e-07 29.6 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC47948.1 - 4.4e-15 55.3 0.3 5.2e-09 35.9 0.1 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 EFC47948.1 - 7.1e-12 44.8 0.2 7.7e-06 25.7 0.1 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 EFC47948.1 - 5.1e-10 39.4 5.6 1.1e-07 31.9 0.0 3.9 5 0 0 5 5 5 2 Galactose oxidase, central domain Ndc1_Nup PF09531.10 EFC47948.1 - 3.7 6.1 6.5 3.6 6.2 6.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase PF00069.25 EFC47949.1 - 3.4e-68 229.9 0.0 5.3e-68 229.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC47949.1 - 7.5e-49 166.3 0.0 1.2e-48 165.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kelch_3 PF13415.6 EFC47949.1 - 3.2e-23 81.5 0.3 7.2e-10 38.9 0.0 5.6 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC47949.1 - 1.1e-20 73.1 4.2 6.8e-10 38.9 0.0 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 EFC47949.1 - 4e-20 71.6 5.0 1.1e-11 44.6 0.0 5.4 4 2 1 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC47949.1 - 8.3e-18 63.7 5.7 3.1e-09 36.3 0.0 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 EFC47949.1 - 3.7e-16 58.7 7.5 4.7e-08 32.8 0.0 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFC47949.1 - 4.3e-16 58.2 5.7 2e-08 33.9 0.0 5.3 5 0 0 5 5 5 2 Kelch motif PB1 PF00564.24 EFC47949.1 - 3.6e-07 30.0 0.2 7.8e-07 28.9 0.2 1.6 1 0 0 1 1 1 1 PB1 domain Pkinase_fungal PF17667.1 EFC47949.1 - 1.9e-06 27.0 0.0 3.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC47949.1 - 0.0015 17.9 0.0 0.0074 15.7 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC47949.1 - 0.0046 16.3 0.0 0.026 13.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 EFC47949.1 - 0.036 13.0 0.2 0.066 12.1 0.2 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Lin-8 PF03353.15 EFC47949.1 - 0.51 9.8 4.7 0.92 9.0 4.7 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Pro-kuma_activ PF09286.11 EFC47951.1 - 9.2e-23 81.1 1.0 3.2e-21 76.1 0.4 2.4 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFC47951.1 - 3.2e-09 36.5 0.9 5e-09 35.9 0.9 1.2 1 0 0 1 1 1 1 Subtilase family EF-hand_7 PF13499.6 EFC47952.1 - 7.1e-19 68.0 10.2 1.1e-10 41.8 1.0 2.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 EFC47952.1 - 2.7e-15 54.7 3.9 2.8e-06 26.5 0.1 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 EFC47952.1 - 5.7e-15 53.9 4.9 4.1e-05 23.2 0.1 3.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 EFC47952.1 - 9.3e-11 40.7 4.2 5.8e-05 22.4 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC47952.1 - 1.1e-08 34.8 4.5 0.00021 21.0 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC47952.1 - 0.0014 18.9 0.3 0.011 16.0 0.1 2.1 1 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC47952.1 - 0.025 14.6 0.6 6.7 6.7 0.0 2.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Piwi PF02171.17 EFC47952.1 - 0.13 11.5 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Piwi domain EF-hand_10 PF14788.6 EFC47952.1 - 0.2 11.5 2.4 19 5.2 0.0 3.0 4 0 0 4 4 4 0 EF hand PIP5K PF01504.18 EFC47953.1 - 8e-78 261.4 0.7 9.1e-78 261.2 0.7 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Asp-B-Hydro_N PF05279.11 EFC47954.1 - 4.2 7.4 20.4 5.7 6.9 8.1 2.2 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region TMEM171 PF15471.6 EFC47954.1 - 9.8 5.1 7.1 24 3.8 7.1 1.6 1 0 0 1 1 1 0 Transmembrane protein family 171 KH_1 PF00013.29 EFC47955.1 - 4.2e-06 26.5 0.2 0.00061 19.6 0.2 2.7 2 0 0 2 2 2 1 KH domain RNA_pol_Rpc4 PF05132.14 EFC47955.1 - 0.0012 19.3 1.4 0.0012 19.3 1.4 2.9 3 0 0 3 3 3 1 RNA polymerase III RPC4 ANAPC4_WD40 PF12894.7 EFC47955.1 - 0.0033 17.7 0.1 1.5 9.1 0.0 3.1 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain 5_3_exonuc_N PF02739.16 EFC47955.1 - 0.0077 16.2 0.1 0.02 14.8 0.1 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain WD40 PF00400.32 EFC47955.1 - 0.096 13.6 3.1 2.2 9.3 0.1 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat Presenilin PF01080.17 EFC47955.1 - 2.6 6.7 8.0 3.9 6.1 4.0 2.3 2 0 0 2 2 2 0 Presenilin YL1 PF05764.13 EFC47955.1 - 5.3 7.1 25.6 0.022 14.9 9.6 2.5 3 0 0 3 3 3 0 YL1 nuclear protein NAP PF00956.18 EFC47956.1 - 4.8e-25 88.3 11.5 1.3e-21 77.0 5.0 2.1 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Mst1_SARAH PF11629.8 EFC47956.1 - 0.0014 18.6 0.4 0.0039 17.2 0.4 1.7 1 0 0 1 1 1 1 C terminal SARAH domain of Mst1 Phage_Mu_Gam PF07352.12 EFC47956.1 - 0.0078 16.1 2.5 0.0078 16.1 2.5 1.8 2 1 0 2 2 2 1 Bacteriophage Mu Gam like protein CENP-Q PF13094.6 EFC47956.1 - 0.035 14.3 1.6 0.036 14.3 0.5 1.6 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4407 PF14362.6 EFC47956.1 - 0.34 10.2 2.0 0.23 10.8 0.6 1.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Sel1 PF08238.12 EFC47957.1 - 4.5e-48 160.6 30.1 1.9e-05 25.2 0.0 13.7 13 0 0 13 13 13 10 Sel1 repeat TPR_2 PF07719.17 EFC47957.1 - 1.6e-16 59.0 33.3 0.00011 22.0 0.1 10.9 9 3 2 11 11 11 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47957.1 - 1.2e-12 47.0 38.8 1.4e-05 24.9 1.1 10.2 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47957.1 - 1.4e-12 46.9 41.0 9.5e-06 25.2 0.4 10.2 10 2 1 11 11 11 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC47957.1 - 1.8e-12 47.4 16.3 0.024 14.9 0.1 8.1 6 3 1 7 7 7 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC47957.1 - 1.6e-08 34.2 8.2 0.00014 21.6 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC47957.1 - 8e-08 32.8 6.6 0.0017 19.0 0.7 6.5 7 1 1 8 8 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC47957.1 - 5.3e-05 23.0 13.0 0.22 11.6 0.1 7.5 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC47957.1 - 0.00025 21.6 2.2 1.9 9.5 0.1 6.5 7 2 1 8 8 6 1 Tetratricopeptide repeat F-box PF00646.33 EFC47957.1 - 0.00068 19.4 0.2 0.0013 18.6 0.2 1.4 1 0 0 1 1 1 1 F-box domain MIT PF04212.18 EFC47957.1 - 0.001 19.1 10.8 0.099 12.7 0.2 6.2 6 1 0 7 7 7 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 EFC47957.1 - 0.0017 18.6 15.0 0.11 13.0 0.4 6.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC47957.1 - 0.012 15.3 24.0 0.9 9.3 0.1 8.2 10 0 0 10 10 9 0 TPR repeat TPR_MalT PF17874.1 EFC47957.1 - 0.022 14.2 1.2 5.3 6.3 0.0 3.5 4 1 0 5 5 4 0 MalT-like TPR region TPR_19 PF14559.6 EFC47957.1 - 0.046 14.2 15.2 1.5 9.4 0.9 5.8 5 2 1 6 6 5 0 Tetratricopeptide repeat Fis1_TPR_N PF14852.6 EFC47957.1 - 0.12 12.0 0.5 20 4.9 0.0 2.5 2 0 0 2 2 2 0 Fis1 N-terminal tetratricopeptide repeat F-box-like PF12937.7 EFC47957.1 - 0.16 11.9 0.2 0.32 10.9 0.2 1.5 1 0 0 1 1 1 0 F-box-like SPO22 PF08631.10 EFC47957.1 - 0.17 11.3 14.1 0.98 8.8 0.2 4.7 3 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like HEPN_Apea PF18739.1 EFC47957.1 - 0.29 11.6 7.0 15 6.0 0.1 4.7 3 1 1 4 4 3 0 Apea-like HEPN TPR_6 PF13174.6 EFC47957.1 - 0.4 11.4 16.8 11 6.9 0.2 7.1 8 1 1 9 9 6 0 Tetratricopeptide repeat LRR_8 PF13855.6 EFC47957.1 - 0.4 10.5 1.6 5.3 6.9 1.1 2.8 1 1 1 2 2 2 0 Leucine rich repeat O-ag_pol_Wzy PF14296.6 EFC47957.1 - 0.66 8.5 3.8 0.28 9.8 0.4 1.9 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy ANAPC3 PF12895.7 EFC47957.1 - 0.82 9.9 23.3 0.19 12.0 2.1 5.5 6 2 1 7 7 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Nuc_deoxyri_tr2 PF15891.5 EFC47958.1 - 1.8e-19 70.0 0.0 2.5e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Sybindin PF04099.12 EFC47959.1 - 5.9e-30 104.1 2.1 6.7e-30 103.9 2.1 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFC47959.1 - 0.00058 20.0 2.1 0.001 19.2 2.1 1.5 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region USP8_dimer PF08969.11 EFC47960.1 - 2.8e-10 40.4 2.2 7.3e-10 39.0 2.2 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain AIM3 PF17096.5 EFC47960.1 - 0.024 15.6 2.1 0.024 15.6 2.1 3.4 2 1 0 2 2 2 0 Altered inheritance of mitochondria protein 3 TSNAXIP1_N PF15739.5 EFC47960.1 - 0.23 11.8 6.4 0.14 12.5 3.2 2.3 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus LRR_4 PF12799.7 EFC47962.1 - 6.8e-11 42.2 44.3 0.025 15.0 2.5 8.3 3 2 6 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC47962.1 - 3.8e-05 23.4 33.3 0.01 15.6 7.1 6.5 3 3 3 6 6 6 5 Leucine rich repeat F-box-like PF12937.7 EFC47962.1 - 0.0004 20.2 0.0 0.00091 19.1 0.0 1.6 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 EFC47962.1 - 0.00086 19.2 21.5 2.1 8.6 0.0 9.3 10 0 0 10 10 10 1 Leucine Rich repeat F-box PF00646.33 EFC47962.1 - 0.011 15.6 0.1 0.11 12.5 0.0 2.4 2 0 0 2 2 2 0 F-box domain FtsJ PF01728.19 EFC47962.1 - 0.097 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase LRR_1 PF00560.33 EFC47962.1 - 3.8 8.4 21.4 40 5.3 0.1 8.6 9 1 0 9 9 9 0 Leucine Rich Repeat Rep_fac-A_3 PF08661.11 EFC47963.1 - 2.3e-06 27.9 0.0 2.6e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Replication factor A protein 3 DUF1143 PF06608.11 EFC47964.1 - 5.3e-05 23.3 2.7 0.048 13.7 0.3 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1143) Ras PF00071.22 EFC47965.1 - 3e-10 39.9 0.0 4.1e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC47965.1 - 8.1e-05 22.8 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Prenyltrans PF00432.21 EFC47966.1 - 1.9e-40 136.3 15.4 8.7e-10 38.2 0.1 6.2 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Spindle_Spc25 PF08234.12 EFC47967.1 - 4e-09 36.5 0.0 1.3e-08 34.9 0.0 1.9 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 DUF1319 PF07028.11 EFC47967.1 - 0.0035 17.5 2.4 0.027 14.7 2.4 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1319) Myosin_tail_1 PF01576.19 EFC47967.1 - 0.013 13.4 12.7 0.015 13.1 12.7 1.0 1 0 0 1 1 1 0 Myosin tail CLZ PF16526.5 EFC47967.1 - 0.021 15.1 3.2 0.054 13.9 0.4 2.8 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CDCA PF18484.1 EFC47967.1 - 0.067 13.1 0.2 0.12 12.2 0.2 1.5 2 0 0 2 2 2 0 Cadmium carbonic anhydrase repeat DUF3335 PF11814.8 EFC47967.1 - 0.13 11.7 0.3 0.25 10.8 0.3 1.4 1 0 0 1 1 1 0 Peptidase_C39 like family Atg14 PF10186.9 EFC47967.1 - 0.23 10.5 6.6 0.29 10.2 6.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ALMT PF11744.8 EFC47967.1 - 0.43 9.3 5.8 0.57 8.9 5.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Phage_GPO PF05929.11 EFC47967.1 - 0.55 9.8 6.6 0.42 10.2 4.8 1.5 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF1664 PF07889.12 EFC47967.1 - 0.98 9.5 7.7 1.6 8.8 2.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF724 PF05266.14 EFC47967.1 - 1.3 8.8 13.1 1 9.2 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) CTNNBL PF08216.11 EFC47967.1 - 2.7 8.2 7.7 4.7 7.4 4.7 2.6 1 1 2 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear Tropomyosin_1 PF12718.7 EFC47967.1 - 3 8.0 14.5 18 5.5 14.5 1.9 1 1 0 1 1 1 0 Tropomyosin like TMPIT PF07851.13 EFC47967.1 - 3.2 6.9 11.4 9.8 5.3 11.2 1.8 1 1 0 1 1 1 0 TMPIT-like protein Exonuc_VII_L PF02601.15 EFC47967.1 - 3.5 7.1 8.0 5.2 6.5 8.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit IATP PF04568.12 EFC47967.1 - 4.2 7.9 7.6 1.4 9.4 1.3 2.3 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP V_ATPase_I PF01496.19 EFC47967.1 - 5 4.9 10.3 6.1 4.6 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2207 PF09972.9 EFC47967.1 - 7.1 5.3 6.2 1.1 7.9 2.4 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Sec8_exocyst PF04048.14 EFC47967.1 - 9.8 6.1 10.5 3.3 7.6 2.6 2.3 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain GCV_T PF01571.21 EFC47968.1 - 1.7e-06 27.6 0.0 2.9e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain ICMT PF04140.14 EFC47969.1 - 6.5e-29 100.2 0.7 1e-28 99.6 0.7 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 EFC47969.1 - 2.1e-10 41.0 1.3 2.7e-10 40.6 1.3 1.2 1 0 0 1 1 1 1 Phospholipid methyltransferase NnrU PF07298.11 EFC47969.1 - 0.00055 19.5 0.0 0.00061 19.4 0.0 1.2 1 0 0 1 1 1 1 NnrU protein DUF1295 PF06966.12 EFC47969.1 - 0.00068 19.2 0.1 0.00089 18.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 EFC47969.1 - 0.00084 18.2 1.0 0.0011 17.9 1.0 1.2 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family IQ PF00612.27 EFC47970.1 - 3.7e-07 29.4 1.3 0.00019 20.9 0.5 2.6 2 0 0 2 2 2 2 IQ calmodulin-binding motif CTP_transf_1 PF01148.20 EFC47971.1 - 0.0028 17.5 22.1 0.019 14.7 22.1 2.5 1 1 0 1 1 1 1 Cytidylyltransferase family F-box PF00646.33 EFC47972.1 - 2.6e-05 24.0 0.8 8.3e-05 22.4 0.8 1.8 1 0 0 1 1 1 1 F-box domain Ras PF00071.22 EFC47972.1 - 0.00018 21.2 0.2 0.00047 19.8 0.0 1.8 2 0 0 2 2 2 1 Ras family F-box-like PF12937.7 EFC47972.1 - 0.00047 20.0 1.3 0.0011 18.8 1.3 1.6 1 0 0 1 1 1 1 F-box-like AAA PF00004.29 EFC47973.1 - 6.7e-39 133.3 0.0 1.1e-38 132.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC47973.1 - 4.9e-12 45.5 0.1 1.5e-11 43.9 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 EFC47973.1 - 7.5e-09 35.5 0.1 2.4e-08 33.9 0.1 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_5 PF07728.14 EFC47973.1 - 0.00027 20.9 0.1 0.00094 19.2 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 EFC47973.1 - 0.00076 19.3 0.0 0.0025 17.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 EFC47973.1 - 0.0021 17.3 0.0 0.0057 15.9 0.0 1.7 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 EFC47973.1 - 0.0024 18.2 0.2 0.01 16.1 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC47973.1 - 0.0025 18.2 0.0 0.0061 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFC47973.1 - 0.0029 18.1 0.4 0.036 14.6 0.0 2.9 3 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 EFC47973.1 - 0.0038 17.0 0.0 0.0098 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 EFC47973.1 - 0.011 15.4 0.1 0.23 11.2 0.1 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 EFC47973.1 - 0.011 15.1 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 EFC47973.1 - 0.019 14.7 0.0 0.048 13.4 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 EFC47973.1 - 0.035 14.2 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC47973.1 - 0.061 12.8 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 EFC47973.1 - 0.067 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 EFC47973.1 - 0.081 13.2 0.1 0.2 11.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 EFC47973.1 - 0.095 12.8 0.0 0.24 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) TsaE PF02367.17 EFC47973.1 - 0.12 12.4 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 EFC47973.1 - 0.12 12.5 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Wzz PF02706.15 EFC47975.1 - 0.054 13.8 0.1 0.054 13.8 0.1 2.9 2 0 0 2 2 2 0 Chain length determinant protein Mitofilin PF09731.9 EFC47975.1 - 0.64 8.8 6.2 1.1 8.0 6.2 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein MCM PF00493.23 EFC47976.1 - 4.6e-100 333.3 0.0 1.1e-99 332.1 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 EFC47976.1 - 6.5e-36 123.0 0.3 1.2e-35 122.1 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFC47976.1 - 3.2e-28 98.0 0.7 5.7e-28 97.2 0.7 1.4 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFC47976.1 - 5.4e-07 29.2 0.2 0.00014 21.3 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFC47976.1 - 1.1e-05 25.4 0.1 0.00011 22.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFC47976.1 - 2.4e-05 24.2 0.1 0.0025 17.7 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) PIG-S PF10510.9 EFC47976.1 - 0.019 13.8 0.1 0.033 13.0 0.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein DEAD PF00270.29 EFC47976.1 - 0.024 14.4 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA PF00004.29 EFC47976.1 - 0.06 13.8 0.0 0.18 12.2 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RcpC PF16976.5 EFC47976.1 - 0.07 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB Mg_chelatase_C PF13335.6 EFC47976.1 - 0.21 12.3 1.2 2.9 8.6 0.1 3.0 3 1 1 4 4 4 0 Magnesium chelatase, subunit ChlI C-terminal VIT1 PF01988.19 EFC47977.1 - 0.0031 17.4 0.3 0.004 17.0 0.3 1.1 1 0 0 1 1 1 1 VIT family ATP-synt_E PF05680.12 EFC47977.1 - 0.12 12.7 5.7 0.17 12.2 5.7 1.2 1 0 0 1 1 1 0 ATP synthase E chain O-antigen_lig PF13425.6 EFC47977.1 - 0.5 9.1 1.9 0.54 9.0 1.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Claudin_2 PF13903.6 EFC47978.1 - 2.2e-05 24.3 0.0 3.4e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction SUR7 PF06687.12 EFC47978.1 - 0.0038 16.9 0.2 0.0047 16.6 0.2 1.1 1 0 0 1 1 1 1 SUR7/PalI family Na_H_Exchanger PF00999.21 EFC47978.1 - 0.0055 15.5 0.4 0.0078 15.0 0.4 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family ABC2_membrane PF01061.24 EFC47978.1 - 0.016 14.6 0.1 0.025 14.0 0.1 1.2 1 0 0 1 1 1 0 ABC-2 type transporter DUF5079 PF16882.5 EFC47978.1 - 0.051 13.5 0.1 0.064 13.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5079) DUF2207 PF09972.9 EFC47978.1 - 0.092 11.5 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mtp PF03821.16 EFC47978.1 - 0.13 11.8 0.6 0.23 11.0 0.2 1.5 2 0 0 2 2 2 0 Golgi 4-transmembrane spanning transporter hNIFK_binding PF12196.8 EFC47978.1 - 0.17 11.4 1.8 0.34 10.4 1.8 1.5 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Fumarate_red_D PF02313.17 EFC47978.1 - 0.57 10.3 3.2 0.47 10.6 0.2 1.9 1 1 1 2 2 2 0 Fumarate reductase subunit D SUIM_assoc PF16619.5 EFC47980.1 - 0.011 15.7 8.0 0.93 9.6 3.1 3.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Syntaxin_2 PF14523.6 EFC47982.1 - 0.0038 17.6 2.6 0.0055 17.0 2.6 1.3 1 0 0 1 1 1 1 Syntaxin-like protein DMPK_coil PF08826.10 EFC47982.1 - 0.015 15.4 1.5 0.015 15.4 1.5 1.9 1 1 1 2 2 2 0 DMPK coiled coil domain like Scaffolding_pro PF11418.8 EFC47982.1 - 0.021 15.4 0.4 0.025 15.1 0.4 1.2 1 0 0 1 1 1 0 Phi29 scaffolding protein MtmB PF05369.12 EFC47982.1 - 0.031 13.1 0.2 0.033 13.0 0.2 1.1 1 0 0 1 1 1 0 Monomethylamine methyltransferase MtmB V-SNARE PF05008.15 EFC47982.1 - 0.069 13.5 3.1 0.1 13.0 3.1 1.4 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Fungal_TACC PF12709.7 EFC47982.1 - 0.069 13.6 2.0 0.069 13.6 2.0 2.0 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins FliD_N PF02465.18 EFC47982.1 - 0.1 13.3 5.3 0.19 12.4 5.3 1.4 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus Spc42p PF11544.8 EFC47982.1 - 0.12 12.4 4.6 0.19 11.8 4.6 1.3 1 0 0 1 1 1 0 Spindle pole body component Spc42p DivIC PF04977.15 EFC47982.1 - 0.18 11.6 4.8 0.13 12.0 1.2 2.0 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 EFC47982.1 - 0.42 10.7 7.2 0.093 12.8 2.4 2.1 1 1 1 2 2 2 0 bZIP transcription factor Serpin PF00079.20 EFC47983.1 - 9.7e-73 245.6 8.9 1.1e-72 245.4 8.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) zf-CSL PF05207.13 EFC47984.1 - 5.1e-24 83.8 0.9 8e-24 83.1 0.9 1.3 1 0 0 1 1 1 1 CSL zinc finger zf-RING_7 PF02591.15 EFC47984.1 - 0.009 16.2 0.1 0.021 15.0 0.1 1.6 1 0 0 1 1 1 1 C4-type zinc ribbon domain DUF3222 PF11519.8 EFC47984.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3222) Kelch_5 PF13854.6 EFC47985.1 - 2e-16 59.6 11.8 6.2e-09 35.6 0.0 6.1 7 0 0 7 7 7 2 Kelch motif Kelch_4 PF13418.6 EFC47985.1 - 2.8e-16 59.2 5.6 3.7e-07 30.0 0.0 5.8 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC47985.1 - 5.9e-14 51.9 4.7 0.00045 20.4 0.0 7.5 7 1 0 7 7 7 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC47985.1 - 4.3e-12 45.5 6.0 2e-05 24.4 0.1 5.8 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 EFC47985.1 - 1.6e-11 44.1 13.5 0.00084 19.5 0.0 5.8 7 0 0 7 7 7 3 Kelch motif Kelch_1 PF01344.25 EFC47985.1 - 5.8e-11 41.8 16.4 0.021 14.4 0.1 8.1 7 1 0 7 7 7 3 Kelch motif DUF2205 PF10224.9 EFC47985.1 - 0.036 14.1 2.0 0.27 11.2 0.4 2.7 2 0 0 2 2 2 0 Short coiled-coil protein DUF1180 PF06679.12 EFC47986.1 - 0.12 12.8 6.5 4.3 7.7 0.2 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1180) DUF4834 PF16118.5 EFC47986.1 - 3.6 8.6 0.0 3.6 8.6 0.0 7.7 8 2 2 10 10 10 0 Domain of unknown function (DUF4834) F-box-like PF12937.7 EFC47987.1 - 0.0053 16.6 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC47987.1 - 0.073 13.0 0.0 0.21 11.5 0.0 1.8 1 0 0 1 1 1 0 F-box domain DUF2996 PF11210.8 EFC47988.1 - 0.086 13.3 0.3 2.8 8.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2996) Biotin_lipoyl PF00364.22 EFC47989.1 - 3.1e-15 55.8 0.3 3.4e-15 55.6 0.3 1.0 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFC47989.1 - 0.004 16.9 0.0 0.0046 16.7 0.0 1.2 1 0 0 1 1 1 1 Biotin-lipoyl like T2SSB PF16537.5 EFC47989.1 - 0.026 14.1 0.0 0.038 13.6 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system protein B HlyD_2 PF12700.7 EFC47989.1 - 0.033 12.9 0.0 0.033 12.9 0.0 1.1 1 0 0 1 1 1 0 HlyD family secretion protein SRP-alpha_N PF04086.13 EFC47990.1 - 0.18 11.7 27.0 0.28 11.1 27.0 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 EFC47990.1 - 0.25 9.6 15.5 0.32 9.2 15.5 1.2 1 0 0 1 1 1 0 CDC45-like protein TAF4 PF05236.14 EFC47990.1 - 0.29 10.8 17.7 0.51 10.0 17.7 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family NARP1 PF12569.8 EFC47990.1 - 0.31 9.9 23.9 0.41 9.5 23.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PTPRCAP PF15713.5 EFC47990.1 - 0.43 10.9 11.2 0.71 10.2 11.2 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SR-25 PF10500.9 EFC47990.1 - 1.1 8.8 39.4 7.2 6.2 39.4 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Connexin PF00029.19 EFC47990.1 - 1.5 8.6 14.1 2.4 7.9 14.1 1.3 1 0 0 1 1 1 0 Connexin MCM_bind PF09739.9 EFC47990.1 - 1.9 6.8 14.1 2.5 6.4 14.1 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NYD-SP12_N PF15015.6 EFC47990.1 - 2.1 6.6 15.9 2.7 6.2 15.9 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal DAAD PF18752.1 EFC47990.1 - 2.3 8.0 15.1 3.6 7.3 15.1 1.3 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase TFIIA PF03153.13 EFC47990.1 - 2.6 8.0 24.1 2.7 7.9 24.0 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1682 PF07946.14 EFC47990.1 - 4.4 6.4 25.4 6.2 5.9 25.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) V_ATPase_I PF01496.19 EFC47990.1 - 5.2 4.8 11.8 7.7 4.3 11.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 EFC47990.1 - 8.6 6.7 33.0 0.23 11.8 26.2 1.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 G0-G1_switch_2 PF15103.6 EFC47990.1 - 9.4 6.7 11.4 24 5.4 11.4 1.7 1 0 0 1 1 1 0 G0/G1 switch protein 2 Serinc PF03348.15 EFC47990.1 - 9.5 5.0 6.8 12 4.7 6.8 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RabGAP-TBC PF00566.18 EFC47991.1 - 8.3e-14 51.7 13.3 2e-09 37.4 1.4 4.0 4 0 0 4 4 4 2 Rab-GTPase-TBC domain NLE PF08154.12 EFC47991.1 - 0.39 11.3 3.8 0.32 11.6 0.3 2.6 2 1 1 3 3 3 0 NLE (NUC135) domain DUF4201 PF13870.6 EFC47992.1 - 7.7e-38 130.0 29.3 7.7e-38 130.0 29.3 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF4201) TPR_2 PF07719.17 EFC47993.1 - 0.028 14.5 3.0 0.53 10.5 0.6 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC47993.1 - 0.03 14.1 4.9 0.55 10.1 1.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC47993.1 - 0.28 11.5 3.2 0.69 10.3 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat SR-25 PF10500.9 EFC47993.1 - 0.37 10.4 5.1 0.61 9.7 5.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ANAPC3 PF12895.7 EFC47993.1 - 7.6 6.8 13.3 16 5.8 7.0 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 ARPC4 PF05856.12 EFC47995.1 - 2.1e-76 255.2 1.8 2.4e-76 255.0 1.8 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) DUF3782 PF12644.7 EFC47996.1 - 0.011 15.9 2.7 0.18 12.0 0.7 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3782) DUF1993 PF09351.10 EFC47996.1 - 0.018 15.2 0.1 4.6 7.4 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) XhlA PF10779.9 EFC47996.1 - 0.062 13.5 0.0 0.33 11.2 0.0 2.3 1 0 0 1 1 1 0 Haemolysin XhlA Presenilin PF01080.17 EFC47996.1 - 0.97 8.1 7.4 1.3 7.7 7.4 1.1 1 0 0 1 1 1 0 Presenilin TFIIA_gamma_N PF02268.16 EFC47997.1 - 2.4e-14 53.1 0.3 4.1e-14 52.3 0.0 1.5 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 EFC47997.1 - 2.1e-11 43.8 1.9 2.1e-11 43.8 1.9 1.9 2 0 0 2 2 2 1 Transcription initiation factor IIA, gamma subunit DUF4366 PF14283.6 EFC47998.1 - 6.4 6.8 9.8 19 5.3 9.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) TGT PF01702.18 EFC48000.1 - 2.3e-134 448.0 0.0 2.6e-134 447.8 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase SRP-alpha_N PF04086.13 EFC48001.1 - 0.3 11.0 14.3 0.064 13.2 10.7 1.7 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal RNA_pol_Rpc4 PF05132.14 EFC48001.1 - 2 8.8 6.1 6.4 7.2 6.1 1.8 1 0 0 1 1 1 0 RNA polymerase III RPC4 zinc_ribbon_13 PF09855.9 EFC48002.1 - 3.7e-24 84.6 3.2 1.7e-23 82.5 1.4 2.0 2 0 0 2 2 2 1 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) RNA_POL_M_15KD PF02150.16 EFC48002.1 - 0.034 14.0 0.7 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit HypA PF01155.19 EFC48002.1 - 0.17 11.9 2.6 0.48 10.4 2.6 1.7 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 EFC48002.1 - 0.37 10.8 4.5 1.1 9.3 0.1 2.5 2 1 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_10 PF10058.9 EFC48002.1 - 0.49 10.2 4.6 1.5 8.6 0.1 2.6 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein Nudix_N_2 PF14803.6 EFC48002.1 - 0.59 10.1 4.8 2.7 8.0 0.1 2.5 3 0 0 3 3 3 0 Nudix N-terminal DUF35_N PF12172.8 EFC48002.1 - 1.3 9.0 3.8 1.1 9.2 0.2 2.4 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) TFIIS_C PF01096.18 EFC48002.1 - 1.3 9.0 7.1 19 5.2 1.7 2.9 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) TFIIA PF03153.13 EFC48003.1 - 0.18 11.8 22.4 0.073 13.1 18.2 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit IKI3 PF04762.12 EFC48004.1 - 1.1e-237 791.5 0.0 1.5e-237 791.1 0.0 1.2 1 0 0 1 1 1 1 IKI3 family TFIIIC_delta PF12657.7 EFC48004.1 - 0.029 14.3 0.1 0.075 13.0 0.1 1.6 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term ThrE PF06738.12 EFC48005.1 - 5.8e-37 127.3 26.3 1.7e-36 125.9 7.8 2.1 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 EFC48005.1 - 1.4e-06 28.5 12.9 1.4e-06 28.5 12.9 2.3 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE CreD PF06123.12 EFC48005.1 - 0.005 15.7 2.5 0.0095 14.8 2.5 1.3 1 0 0 1 1 1 1 Inner membrane protein CreD AKAP7_NLS PF10469.9 EFC48005.1 - 0.12 12.3 0.1 0.49 10.2 0.0 1.9 1 1 1 2 2 2 0 AKAP7 2'5' RNA ligase-like domain DUF3484 PF11983.8 EFC48005.1 - 0.24 12.5 2.6 17 6.6 0.1 2.4 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Chromate_transp PF02417.15 EFC48005.1 - 3.5 7.8 27.4 0.044 13.9 12.8 2.9 2 1 1 3 3 3 0 Chromate transporter Tmemb_cc2 PF10267.9 EFC48006.1 - 0.019 14.1 0.1 0.019 14.1 0.1 2.3 2 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Kinesin PF00225.23 EFC48007.1 - 2.1e-115 385.2 0.1 2.1e-115 385.2 0.1 2.6 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC48007.1 - 2.2e-26 92.6 0.0 2.2e-26 92.6 0.0 2.9 3 1 0 3 3 3 1 Microtubule binding AAA_16 PF13191.6 EFC48007.1 - 0.055 13.9 4.4 0.061 13.7 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 EFC48007.1 - 5.4 7.3 10.4 0.85 9.9 0.0 3.2 3 1 1 4 4 4 0 AAA domain CDC50 PF03381.15 EFC48008.1 - 1.2e-87 294.0 0.1 1.5e-87 293.7 0.1 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DHHC PF01529.20 EFC48008.1 - 0.04 14.0 0.3 1.3 9.1 0.4 2.3 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF1218 PF06749.12 EFC48008.1 - 0.04 14.4 0.1 2.1 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) LRR_9 PF14580.6 EFC48009.1 - 2.9e-15 56.2 2.5 2.9e-15 56.2 1.9 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC48009.1 - 1.7e-11 44.1 14.5 5.9e-07 29.7 5.8 4.1 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC48009.1 - 1.3e-07 31.2 13.7 2.4e-05 24.0 7.7 3.2 1 1 2 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 EFC48009.1 - 0.22 11.7 5.3 3.7 7.8 0.2 3.4 3 0 0 3 3 3 0 Leucine Rich repeat HhH-GPD PF00730.25 EFC48010.1 - 1.8e-09 38.0 0.0 3.7e-09 37.0 0.0 1.5 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.12 EFC48010.1 - 1.3e-07 31.7 0.2 3.2e-07 30.5 0.0 1.7 2 0 0 2 2 2 1 8-oxoguanine DNA glycosylase, N-terminal domain COX_ARM PF06481.14 EFC48010.1 - 0.031 14.2 0.0 0.063 13.2 0.0 1.5 1 0 0 1 1 1 0 COX Aromatic Rich Motif NAD_binding_1 PF00175.21 EFC48011.1 - 1.5e-12 48.1 0.0 1.9e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFC48011.1 - 2.7e-08 34.1 0.3 7.9e-07 29.3 0.1 2.0 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Dexa_ind PF15198.6 EFC48011.1 - 0.026 14.6 0.1 0.042 14.0 0.1 1.4 1 0 0 1 1 1 0 Dexamethasone-induced Acetyltransf_9 PF13527.7 EFC48012.1 - 0.18 11.9 0.0 0.28 11.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TMC PF07810.13 EFC48013.1 - 2e-12 47.7 0.5 2e-12 47.7 0.5 2.6 3 0 0 3 3 3 1 TMC domain Cystatin PF00031.21 EFC48014.1 - 3.9e-05 23.8 0.1 7.1e-05 23.0 0.1 1.4 1 1 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EFC48014.1 - 0.0081 16.5 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor WD40 PF00400.32 EFC48015.1 - 3.6e-21 75.1 25.1 3.3e-05 24.6 0.3 9.8 10 0 0 10 10 10 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48015.1 - 5e-10 39.5 0.2 0.97 9.8 0.0 7.1 7 1 1 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Mcl1_mid PF12341.8 EFC48015.1 - 0.016 14.6 0.3 0.11 11.9 0.1 2.4 2 1 1 3 3 3 0 Minichromosome loss protein, Mcl1, middle region Sybindin PF04099.12 EFC48016.1 - 3.5e-34 117.8 0.0 4.2e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 EFC48016.1 - 1.5e-05 25.1 0.0 1.9e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Transketolase_N PF00456.21 EFC48017.1 - 9.5e-130 432.4 0.0 1.3e-129 431.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 EFC48017.1 - 5.2e-42 143.5 0.0 9.6e-42 142.7 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 EFC48017.1 - 7.8e-08 32.2 0.1 1.8e-07 31.0 0.1 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 EFC48017.1 - 0.0003 20.1 0.0 0.00066 19.0 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Glyco_hydro_79n PF03662.14 EFC48017.1 - 0.062 12.2 0.1 0.11 11.4 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain XFP_C PF09363.10 EFC48017.1 - 0.17 11.4 0.2 1.7 8.1 0.1 2.5 3 0 0 3 3 3 0 XFP C-terminal domain Myb_DNA-bind_7 PF15963.5 EFC48018.1 - 7.5e-28 96.3 5.4 3.4e-27 94.2 5.4 2.2 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 EFC48018.1 - 2.7e-06 27.5 0.0 6.5e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC48018.1 - 0.006 16.8 1.9 0.012 15.9 0.4 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_S15 PF00312.22 EFC48019.1 - 3.4e-29 100.9 1.8 4.4e-29 100.5 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S15 Rhomboid PF01694.22 EFC48020.1 - 1.2e-05 25.4 8.4 8.8e-05 22.5 7.8 2.2 2 0 0 2 2 2 1 Rhomboid family MORN PF02493.20 EFC48020.1 - 0.25 11.3 1.1 0.52 10.3 0.1 2.1 2 0 0 2 2 2 0 MORN repeat Zn_clus PF00172.18 EFC48021.1 - 1.6e-09 37.7 11.9 1.6e-09 37.7 11.9 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_71 PF03659.14 EFC48022.1 - 5.6e-23 81.4 4.5 9e-23 80.7 4.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Glyco_hydro_99 PF16317.5 EFC48022.1 - 0.0052 15.9 0.3 0.017 14.3 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 99 Aminotran_5 PF00266.19 EFC48023.1 - 4.1e-57 193.8 1.0 6.1e-57 193.3 1.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFC48023.1 - 0.0024 17.1 0.0 0.0039 16.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II ARL2_Bind_BART PF11527.8 EFC48024.1 - 5.8e-30 103.8 0.8 5.8e-30 103.8 0.8 3.1 3 1 0 3 3 3 1 The ARF-like 2 binding protein BART UIM PF02809.20 EFC48024.1 - 6.9e-06 25.6 10.2 0.00021 21.0 0.5 4.4 2 0 0 2 2 2 2 Ubiquitin interaction motif Med2 PF11214.8 EFC48024.1 - 0.024 14.8 0.4 0.024 14.8 0.4 8.4 5 2 2 7 7 7 0 Mediator complex subunit 2 Hist_deacetyl PF00850.19 EFC48025.1 - 2.7e-84 283.3 0.1 3.7e-84 282.8 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DEAD PF00270.29 EFC48026.1 - 8.2e-40 136.4 0.0 2e-39 135.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC48026.1 - 4.7e-26 91.3 2.8 2.9e-25 88.8 0.0 3.4 5 0 0 5 5 5 1 Helicase conserved C-terminal domain Ndc1_Nup PF09531.10 EFC48026.1 - 0.0012 17.7 4.3 0.0021 16.9 4.3 1.3 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup AAA_22 PF13401.6 EFC48026.1 - 0.059 13.7 0.1 0.35 11.1 0.1 2.3 1 1 0 1 1 1 0 AAA domain DUF5053 PF16476.5 EFC48026.1 - 0.11 12.1 0.2 16 5.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5053) GAGA_bind PF06217.12 EFC48026.1 - 1.1 9.5 16.6 0.87 9.8 0.5 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family ORC6 PF05460.13 EFC48026.1 - 1.3 8.3 22.4 2.5 7.3 22.4 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Hamartin PF04388.12 EFC48026.1 - 3.7 6.1 25.8 0.069 11.8 18.6 1.6 2 0 0 2 2 2 0 Hamartin protein Pyr_redox_2 PF07992.14 EFC48027.1 - 1.1e-45 156.2 0.0 7.5e-28 97.6 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 EFC48027.1 - 1.8e-26 92.5 0.1 3.3e-26 91.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 EFC48027.1 - 8.1e-08 31.9 0.6 0.009 15.3 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC48027.1 - 1.9e-07 31.5 4.4 4.6e-05 23.9 0.4 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC48027.1 - 4.4e-05 22.7 0.8 0.00054 19.2 0.4 2.5 3 0 0 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 EFC48027.1 - 0.00026 20.3 0.3 0.049 12.9 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 EFC48027.1 - 0.0013 17.9 0.3 0.0013 17.9 0.3 2.2 2 1 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 EFC48027.1 - 0.0013 18.0 0.1 0.0025 17.1 0.1 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_7 PF13241.6 EFC48027.1 - 0.0017 18.7 0.1 0.056 13.9 0.0 2.5 3 0 0 3 3 2 1 Putative NAD(P)-binding HI0933_like PF03486.14 EFC48027.1 - 0.0032 16.2 0.2 0.0057 15.4 0.2 1.4 1 0 0 1 1 1 1 HI0933-like protein K_oxygenase PF13434.6 EFC48027.1 - 0.0082 15.3 0.0 3.5 6.7 0.1 2.3 1 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 EFC48027.1 - 0.015 14.7 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase XdhC_C PF13478.6 EFC48027.1 - 0.015 15.8 0.0 5.2 7.6 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain DAO PF01266.24 EFC48027.1 - 0.081 12.5 0.1 6.1 6.3 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC48027.1 - 0.084 12.1 0.3 7.1 5.8 0.1 2.9 3 0 0 3 3 3 0 FAD binding domain NAD_binding_8 PF13450.6 EFC48027.1 - 0.13 12.5 3.6 0.43 10.8 0.5 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Pkinase PF00069.25 EFC48028.1 - 2.7e-75 253.2 0.1 4.1e-75 252.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48028.1 - 8.5e-40 136.7 0.1 1.4e-39 136.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 EFC48028.1 - 1.1e-28 99.2 0.8 1.4e-17 63.7 0.1 3.2 3 0 0 3 3 3 2 POLO box duplicated region Kinase-like PF14531.6 EFC48028.1 - 6.7e-10 38.7 0.0 2.4e-07 30.4 0.0 2.3 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFC48028.1 - 3.6e-06 26.0 0.8 1.6e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFC48028.1 - 5.2e-05 22.7 0.0 0.00011 21.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFC48028.1 - 5.9e-05 22.2 0.1 0.00015 20.9 0.1 1.7 1 0 0 1 1 1 1 Haspin like kinase domain Inos-1-P_synth PF01658.17 EFC48028.1 - 0.15 12.3 1.2 0.51 10.6 0.6 2.0 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase Enolase_C PF00113.22 EFC48029.1 - 5.5e-108 360.7 0.7 7.6e-108 360.2 0.7 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 EFC48029.1 - 7.3e-46 155.6 0.2 1.9e-45 154.2 0.2 1.8 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 EFC48029.1 - 0.0081 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like Pepsin-I3 PF06394.13 EFC48030.1 - 0.073 13.3 4.2 0.23 11.7 0.0 2.5 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain Lyase_catalyt PF09093.11 EFC48030.1 - 0.18 10.9 3.8 0.26 10.4 3.8 1.2 1 0 0 1 1 1 0 Lyase, catalytic DSBA PF01323.20 EFC48033.1 - 2.6e-16 60.0 0.0 4e-16 59.4 0.0 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain BTB PF00651.31 EFC48034.1 - 3.2e-12 46.7 1.4 6.8e-11 42.4 0.2 2.9 3 0 0 3 3 3 1 BTB/POZ domain DUF3342 PF11822.8 EFC48034.1 - 0.00033 20.8 0.4 0.0013 18.8 0.4 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3342) TPR_2 PF07719.17 EFC48035.1 - 1.5e-12 46.6 3.4 2.5e-07 30.3 0.7 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48035.1 - 6e-10 38.5 11.5 1.9e-07 30.6 1.5 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48035.1 - 8.5e-08 31.8 9.8 3.3e-05 23.7 1.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48035.1 - 1.3e-07 32.0 1.7 3.8e-06 27.3 0.3 2.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48035.1 - 2.3e-07 30.4 4.6 0.0024 17.5 0.6 2.5 2 0 0 2 2 2 2 TPR repeat TPR_16 PF13432.6 EFC48035.1 - 7.8e-07 29.6 0.0 3.1e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48035.1 - 3e-06 27.4 2.0 3.8e-05 23.9 0.9 2.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48035.1 - 2.5e-05 24.0 0.9 0.0011 18.9 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC48035.1 - 4.4e-05 23.5 3.0 0.00023 21.2 0.4 2.9 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 EFC48035.1 - 6.1e-05 23.5 0.0 0.022 15.6 0.2 2.6 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC48035.1 - 6.7e-05 23.0 0.0 9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 EFC48035.1 - 0.00014 20.4 0.9 0.00019 20.0 0.0 1.6 2 1 0 2 2 2 1 Spermatogenesis-associated, N-terminal TPR_6 PF13174.6 EFC48035.1 - 0.00024 21.5 2.9 0.0026 18.3 0.5 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC48035.1 - 0.00037 20.6 5.9 0.00042 20.5 0.6 2.4 3 0 0 3 3 2 1 Anaphase-promoting complex, cyclosome, subunit 3 NARP1 PF12569.8 EFC48035.1 - 0.00066 18.7 0.3 0.0016 17.5 0.1 1.6 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_17 PF13431.6 EFC48035.1 - 0.0047 17.2 2.3 12 6.6 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 EFC48035.1 - 0.042 13.6 0.5 1.7 8.3 0.2 2.3 1 1 0 2 2 2 0 Tetratricopeptide repeat-like domain RPN7 PF10602.9 EFC48035.1 - 0.046 13.4 1.9 1.7 8.3 0.0 2.9 3 0 0 3 3 3 0 26S proteasome subunit RPN7 DUF3856 PF12968.7 EFC48035.1 - 0.062 13.4 0.3 0.12 12.4 0.1 1.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_18 PF13512.6 EFC48035.1 - 0.1 12.7 0.8 15 5.7 0.0 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFC48035.1 - 0.41 10.7 5.0 0.061 13.3 1.1 1.6 2 0 0 2 2 2 0 Putative TPR-like repeat bZIP_1 PF00170.21 EFC48037.1 - 5.3e-13 48.9 11.3 5.3e-13 48.9 11.3 3.5 3 1 1 4 4 4 2 bZIP transcription factor bZIP_2 PF07716.15 EFC48037.1 - 5.7e-09 35.9 4.8 5.7e-09 35.9 4.8 3.5 2 1 1 3 3 3 2 Basic region leucine zipper bZIP_Maf PF03131.17 EFC48037.1 - 6.1e-09 36.3 5.1 6.1e-09 36.3 5.1 3.7 4 1 1 5 5 5 1 bZIP Maf transcription factor YabA PF06156.13 EFC48037.1 - 0.038 14.6 1.3 0.038 14.6 1.3 3.8 2 1 0 3 3 3 0 Initiation control protein YabA TSC22 PF01166.18 EFC48037.1 - 0.3 11.4 5.2 0.11 12.8 1.3 2.3 3 0 0 3 3 3 0 TSC-22/dip/bun family DALR_1 PF05746.15 EFC48037.1 - 1.5 9.0 5.6 1 9.6 1.0 2.6 2 1 0 2 2 2 0 DALR anticodon binding domain tRNA-synt_1b PF00579.25 EFC48038.1 - 8.5e-62 209.1 0.0 1.3e-61 208.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) LRR_5 PF13306.6 EFC48038.1 - 0.0065 16.4 0.1 0.014 15.3 0.1 1.6 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) NADH_dehy_S2_C PF06444.11 EFC48040.1 - 4.1 8.0 6.5 70 4.0 5.1 2.5 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus Resistin PF06954.11 EFC48041.1 - 0.083 13.4 1.9 1.3 9.7 1.9 2.2 1 1 0 1 1 1 0 Resistin ATP-synt_8 PF00895.20 EFC48041.1 - 5.4 7.6 5.7 4.7 7.8 1.1 2.4 2 0 0 2 2 2 0 ATP synthase protein 8 p450 PF00067.22 EFC48042.1 - 1.5e-09 37.1 0.2 2e-09 36.7 0.2 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF5033 PF16436.5 EFC48042.1 - 0.019 14.9 0.1 0.037 14.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5033) p450 PF00067.22 EFC48043.1 - 1.7e-44 152.4 0.8 2e-44 152.1 0.8 1.0 1 0 0 1 1 1 1 Cytochrome P450 Tam41_Mmp37 PF09139.11 EFC48044.1 - 9.4e-68 229.0 11.5 9.8e-66 222.4 11.5 2.3 1 1 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial G_glu_transpept PF01019.21 EFC48045.1 - 2e-137 459.1 0.0 2.5e-137 458.8 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Cation_ATPase_C PF00689.21 EFC48046.1 - 1.5e-36 125.9 9.4 1.5e-36 125.9 9.4 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFC48046.1 - 1.5e-15 57.2 2.9 3.2e-15 56.1 0.1 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 EFC48046.1 - 1.9e-07 31.1 0.0 4e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 EFC48046.1 - 1.6e-05 25.3 0.0 2.8e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFC48046.1 - 0.00065 19.3 0.0 0.0057 16.3 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus RecO_N PF11967.8 EFC48046.1 - 0.027 14.4 0.0 0.079 12.9 0.0 1.8 1 0 0 1 1 1 0 Recombination protein O N terminal DUF3545 PF12065.8 EFC48046.1 - 0.27 11.3 0.7 0.85 9.7 0.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) DUF2231 PF09990.9 EFC48046.1 - 0.86 10.1 7.1 60 4.1 0.5 4.6 5 0 0 5 5 5 0 Predicted membrane protein (DUF2231) DUF3180 PF11377.8 EFC48046.1 - 2.1 8.5 8.2 0.2 11.8 1.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) FANCI_S2 PF14676.6 EFC48047.1 - 8.2e-44 149.8 0.8 8.2e-44 149.8 0.8 4.3 5 0 0 5 5 5 1 FANCI solenoid 2 FANCI_S1 PF14675.6 EFC48047.1 - 4e-31 108.3 0.2 4e-31 108.3 0.2 3.2 4 0 0 4 4 4 1 FANCI solenoid 1 FANCI_S4 PF14678.6 EFC48047.1 - 4.5e-27 94.8 4.2 4.5e-27 94.8 4.2 5.1 4 1 0 4 4 4 1 FANCI solenoid 4 FANCI_HD2 PF14680.6 EFC48047.1 - 7.8e-26 90.8 0.1 7.8e-26 90.8 0.1 4.6 5 1 0 5 5 5 1 FANCI helical domain 2 FANCI_HD1 PF14679.6 EFC48047.1 - 2.9e-06 27.1 6.5 3.1e-06 27.1 0.4 3.8 4 1 1 5 5 5 1 FANCI helical domain 1 DUF1106 PF06523.11 EFC48047.1 - 0.048 13.7 0.1 0.19 11.8 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) Band_7 PF01145.25 EFC48048.1 - 0.0043 17.1 0.0 0.01 15.8 0.0 1.6 1 0 0 1 1 1 1 SPFH domain / Band 7 family DUF5040 PF16443.5 EFC48048.1 - 0.077 12.4 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5040) GLTP PF08718.11 EFC48049.1 - 0.051 13.9 2.2 0.069 13.4 0.8 1.9 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) MSG PF02349.15 EFC48049.1 - 0.97 9.7 6.7 1.5 9.0 0.0 3.2 2 2 0 2 2 2 0 Major surface glycoprotein Lactamase_B PF00753.27 EFC48050.1 - 2.7e-16 60.1 0.3 5.3e-16 59.2 0.3 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC48050.1 - 0.0083 15.7 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain WD40 PF00400.32 EFC48051.1 - 2.4e-18 66.1 7.4 4.4e-06 27.3 0.3 6.8 6 0 0 6 6 6 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 EFC48051.1 - 0.00069 19.2 8.9 0.00069 19.2 8.9 2.4 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type DZR PF12773.7 EFC48051.1 - 0.015 15.4 7.2 0.015 15.4 7.2 2.3 1 1 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 EFC48051.1 - 0.61 9.6 6.7 0.57 9.7 1.4 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_16 PF17034.5 EFC48051.1 - 0.73 10.1 17.6 0.12 12.6 4.6 2.6 1 1 1 2 2 2 0 Zinc-ribbon like family Zn-ribbon_8 PF09723.10 EFC48051.1 - 4.6 7.4 6.3 11 6.3 0.8 2.9 2 0 0 2 2 2 0 Zinc ribbon domain zf-CCHC_3 PF13917.6 EFC48051.1 - 5.2 7.1 15.7 1.9 8.5 6.2 3.3 3 0 0 3 3 3 0 Zinc knuckle RGS PF00615.19 EFC48052.1 - 2.9e-15 56.6 5.0 2.9e-15 56.6 5.0 2.8 2 1 0 2 2 2 1 Regulator of G protein signaling domain TPR_12 PF13424.6 EFC48054.1 - 0.0002 21.6 3.1 0.16 12.2 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC48054.1 - 0.014 15.3 0.3 5.5 7.0 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat DeoRC PF00455.22 EFC48054.1 - 0.12 12.3 0.8 0.34 10.8 0.3 2.0 2 0 0 2 2 2 0 DeoR C terminal sensor domain TPR_1 PF00515.28 EFC48054.1 - 1.1 9.2 3.3 67 3.6 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48054.1 - 1.2 9.6 10.6 22 5.6 0.3 5.9 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48054.1 - 4.8 7.5 10.2 1.2e+02 3.1 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat MatE PF01554.18 EFC48055.1 - 0.017 14.8 3.8 0.017 14.8 3.8 2.4 1 1 0 2 2 2 0 MatE DUF1772 PF08592.11 EFC48055.1 - 2.3 8.5 8.1 12 6.2 0.0 3.0 2 1 0 3 3 3 0 Domain of unknown function (DUF1772) Cob_adeno_trans PF01923.18 EFC48056.1 - 3.4e-47 160.6 0.2 2.4e-45 154.6 0.2 2.0 1 1 0 1 1 1 1 Cobalamin adenosyltransferase Mpp10 PF04006.12 EFC48057.1 - 2.6e-63 214.5 83.2 4.6e-49 167.4 55.0 2.9 1 1 1 2 2 2 2 Mpp10 protein LRR_4 PF12799.7 EFC48058.1 - 0.00022 21.5 19.3 0.047 14.1 0.2 7.8 5 3 3 8 8 8 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC48058.1 - 0.0018 18.2 21.4 5.5 7.3 0.1 9.5 13 0 0 13 13 13 2 Leucine Rich repeat FERM_M PF00373.18 EFC48058.1 - 0.084 13.3 0.0 0.24 11.8 0.0 1.5 1 1 0 1 1 1 0 FERM central domain LRR_1 PF00560.33 EFC48058.1 - 0.093 13.3 11.5 1e+02 4.1 0.2 7.7 9 1 0 9 9 9 0 Leucine Rich Repeat GSH-S_ATP PF02955.16 EFC48059.1 - 0.0022 17.4 0.0 0.016 14.6 0.0 2.1 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain His_binding PF02098.16 EFC48059.1 - 0.048 13.7 2.4 0.2 11.7 0.1 2.7 2 1 1 3 3 3 0 Tick histamine binding protein GrpE PF01025.19 EFC48060.1 - 1.9e-40 138.2 11.1 1.9e-40 138.2 11.1 2.3 1 1 1 2 2 1 1 GrpE TFIIA PF03153.13 EFC48060.1 - 0.0016 18.5 16.6 0.0019 18.3 16.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2514 PF10721.9 EFC48060.1 - 0.006 16.6 11.6 0.011 15.8 11.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2514) DUF4175 PF13779.6 EFC48060.1 - 0.01 13.8 19.2 0.012 13.6 19.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF966 PF06136.13 EFC48060.1 - 0.02 14.6 13.3 0.027 14.2 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Mitofilin PF09731.9 EFC48060.1 - 0.036 12.9 20.7 0.046 12.6 20.7 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF3584 PF12128.8 EFC48060.1 - 0.081 10.4 27.8 0.1 10.1 27.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atg14 PF10186.9 EFC48060.1 - 0.19 10.8 14.3 0.24 10.4 14.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CRT10 PF08728.10 EFC48060.1 - 0.44 8.7 10.0 0.55 8.3 10.0 1.1 1 0 0 1 1 1 0 CRT10 Roughex PF06020.11 EFC48060.1 - 0.5 9.4 11.2 0.76 8.8 11.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Pex14_N PF04695.13 EFC48060.1 - 0.63 10.7 13.6 0.35 11.5 11.5 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 EFC48060.1 - 0.69 9.1 4.2 0.75 8.9 4.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NEMP PF10225.9 EFC48060.1 - 1.1 8.9 2.1 1.5 8.4 2.1 1.4 1 0 0 1 1 1 0 NEMP family Ndc1_Nup PF09531.10 EFC48060.1 - 1.1 7.9 11.7 1.4 7.6 11.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFC48060.1 - 1.1 7.9 15.0 1.3 7.7 15.0 1.1 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 EFC48060.1 - 1.2 9.4 19.3 2.3 8.4 19.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SLC12 PF03522.15 EFC48060.1 - 1.3 8.0 15.2 1.6 7.6 15.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CLN3 PF02487.17 EFC48060.1 - 1.6 7.7 6.1 2.1 7.3 6.1 1.3 1 0 0 1 1 1 0 CLN3 protein XAP5 PF04921.14 EFC48060.1 - 2 8.2 16.9 3.8 7.3 16.9 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator MDM10 PF12519.8 EFC48060.1 - 2.4 6.9 13.7 3.4 6.4 13.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Mg_chelatase_C PF13335.6 EFC48060.1 - 2.7 8.7 8.2 2.2 8.9 6.1 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal Aminopep PF10023.9 EFC48060.1 - 5.1 6.4 14.2 7 5.9 14.2 1.2 1 0 0 1 1 1 0 Putative aminopeptidase ARD PF03079.14 EFC48060.1 - 6 7.0 10.1 15 5.7 10.1 1.6 1 0 0 1 1 1 0 ARD/ARD' family Spt20 PF12090.8 EFC48060.1 - 8.5 5.9 34.7 14 5.2 33.9 1.8 1 1 0 1 1 1 0 Spt20 family SID-1_RNA_chan PF13965.6 EFC48060.1 - 8.9 4.6 5.7 12 4.2 5.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MACPF PF01823.19 EFC48061.1 - 3.5e-09 37.1 0.3 1.4e-08 35.1 0.3 1.8 1 1 0 1 1 1 1 MAC/Perforin domain Cnl2_NKP2 PF09447.10 EFC48061.1 - 0.041 14.0 0.1 0.11 12.6 0.1 1.7 1 0 0 1 1 1 0 Cnl2/NKP2 family protein Cellulose_synt PF03552.14 EFC48062.1 - 0.071 11.6 0.6 0.077 11.5 0.6 1.0 1 0 0 1 1 1 0 Cellulose synthase TPR_2 PF07719.17 EFC48063.1 - 1.3e-15 56.1 7.2 2.7e-06 27.1 0.3 4.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48063.1 - 9.1e-15 53.8 7.3 2.1e-05 24.1 0.4 4.1 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48063.1 - 3.8e-13 48.4 0.4 0.0058 16.6 0.1 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48063.1 - 6.5e-13 48.3 0.2 0.0015 19.2 0.2 4.7 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48063.1 - 2.2e-12 46.2 1.0 0.00016 21.6 0.1 4.5 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48063.1 - 6.7e-11 42.7 0.3 5.8e-05 23.7 0.3 4.0 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48063.1 - 2e-10 40.3 6.9 0.19 12.2 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48063.1 - 3.4e-10 39.4 5.4 0.048 13.4 0.0 5.2 3 2 2 5 5 5 3 TPR repeat TPR_19 PF14559.6 EFC48063.1 - 3.9e-08 33.7 0.4 0.002 18.6 0.9 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC48063.1 - 7e-06 26.1 0.9 0.0016 18.6 0.6 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48063.1 - 9.1e-06 25.9 1.4 0.21 11.9 0.0 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC48063.1 - 1.4e-05 25.4 0.3 0.031 14.9 0.0 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat PPTA PF01239.22 EFC48063.1 - 0.01 15.6 1.3 0.24 11.2 0.1 2.7 2 0 0 2 2 2 1 Protein prenyltransferase alpha subunit repeat BTAD PF03704.17 EFC48063.1 - 0.03 14.7 1.2 0.12 12.8 0.7 2.0 2 0 0 2 2 2 0 Bacterial transcriptional activator domain ANAPC3 PF12895.7 EFC48063.1 - 0.041 14.1 8.3 0.18 12.1 3.2 3.4 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 EFC48063.1 - 0.3 10.8 7.3 12 5.6 0.1 3.6 3 1 2 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 PDEase_I PF00233.19 EFC48064.1 - 6e-83 278.2 3.1 1.1e-82 277.4 3.1 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Vps51 PF08700.11 EFC48064.1 - 0.2 11.7 4.6 0.22 11.6 0.6 3.1 3 1 0 3 3 3 0 Vps51/Vps67 NHL PF01436.21 EFC48065.1 - 0.0014 18.6 0.1 1.1 9.4 0.0 3.9 5 0 0 5 5 5 2 NHL repeat TPR_1 PF00515.28 EFC48067.1 - 4.2e-16 58.0 19.0 1.6e-05 24.5 1.5 3.7 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48067.1 - 6.1e-14 50.9 20.7 1.9e-05 24.4 1.4 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48067.1 - 2.4e-13 49.1 13.9 3.3e-06 26.9 1.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48067.1 - 1.8e-11 43.5 12.1 0.00036 20.2 0.1 3.3 1 1 2 3 3 3 3 TPR repeat TPR_7 PF13176.6 EFC48067.1 - 3e-10 39.4 1.3 0.015 15.3 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48067.1 - 4.1e-09 36.8 5.4 0.00077 19.9 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48067.1 - 7.3e-08 32.6 0.4 0.021 15.6 0.3 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48067.1 - 8.2e-08 32.8 0.1 2.1e-05 25.1 0.6 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48067.1 - 4.8e-07 30.0 2.3 1.7e-05 25.0 1.4 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48067.1 - 1.4e-05 25.1 11.0 0.006 16.9 1.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 EFC48067.1 - 1.9e-05 25.2 1.1 8.5e-05 23.0 1.1 1.9 1 1 0 1 1 1 1 Bacterial transcriptional activator domain TPR_9 PF13371.6 EFC48067.1 - 1.9e-05 24.7 0.1 6.5e-05 23.0 0.3 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC48067.1 - 2.8e-05 24.3 6.5 5.4e-05 23.3 6.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 STI1 PF17830.1 EFC48067.1 - 0.00026 20.8 0.8 0.00026 20.8 0.8 4.4 4 2 0 4 4 4 1 STI1 domain TPR_10 PF13374.6 EFC48067.1 - 0.00044 20.0 1.3 0.15 12.0 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC48067.1 - 0.00046 20.6 11.3 0.0047 17.5 1.1 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat DUF627 PF04781.12 EFC48067.1 - 0.0095 15.9 1.3 0.024 14.6 1.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF627) DUF3856 PF12968.7 EFC48067.1 - 0.03 14.4 3.9 5 7.2 3.9 3.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) ATP-synt_DE PF00401.20 EFC48067.1 - 0.33 11.3 0.2 0.33 11.3 0.2 2.9 3 0 0 3 3 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Wzy_C_2 PF11846.8 EFC48067.1 - 0.91 9.4 3.4 17 5.3 0.3 2.2 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal NARP1 PF12569.8 EFC48067.1 - 1.1 8.0 21.8 0.015 14.3 5.4 2.6 1 1 2 3 3 3 0 NMDA receptor-regulated protein 1 HrpB7 PF09486.10 EFC48067.1 - 4.9 7.5 11.5 43 4.5 11.5 2.1 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) IFT81_CH PF18383.1 EFC48068.1 - 1.5e-24 86.6 1.2 1.5e-24 86.6 1.2 2.0 2 0 0 2 2 2 1 Intraflagellar transport 81 calponin homology domain Carot_N PF09150.10 EFC48068.1 - 0.017 15.0 0.8 0.017 15.0 0.8 1.6 2 0 0 2 2 2 0 Orange carotenoid protein, N-terminal MCU PF04678.13 EFC48068.1 - 0.074 13.1 3.8 0.043 13.9 1.9 1.6 2 0 0 2 2 2 0 Mitochondrial calcium uniporter UQ_con PF00179.26 EFC48069.1 - 8e-49 164.9 0.1 9e-49 164.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC48069.1 - 9.3e-06 25.4 0.0 1.2e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 EFC48069.1 - 0.0034 17.2 0.1 0.007 16.2 0.1 1.5 1 1 0 1 1 1 1 UEV domain ATP12 PF07542.11 EFC48069.1 - 0.046 13.8 0.1 0.073 13.2 0.1 1.3 1 0 0 1 1 1 0 ATP12 chaperone protein RasGEF PF00617.19 EFC48070.1 - 9.9e-36 123.6 0.3 9.9e-36 123.6 0.3 1.9 2 0 0 2 2 2 1 RasGEF domain F-box-like PF12937.7 EFC48070.1 - 5e-05 23.1 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48070.1 - 0.00077 19.3 0.5 0.0034 17.2 0.2 2.3 2 0 0 2 2 2 1 F-box domain DUF4803 PF16061.5 EFC48070.1 - 0.0039 16.7 1.2 0.0085 15.6 1.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4803) RasGEF_N PF00618.20 EFC48070.1 - 0.044 14.0 4.1 0.2 11.9 2.6 2.6 2 0 0 2 2 2 0 RasGEF N-terminal motif Luteo_P1-P2 PF08467.10 EFC48070.1 - 0.095 11.9 1.3 0.23 10.7 0.3 2.0 2 0 0 2 2 2 0 Luteovirus RNA polymerase P1-P2/replicase DUF4030 PF13222.6 EFC48070.1 - 0.15 12.2 1.8 0.3 11.2 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4030) PRP38 PF03371.15 EFC48071.1 - 2.1e-52 177.5 0.1 2.3e-52 177.3 0.1 1.0 1 0 0 1 1 1 1 PRP38 family DUF4116 PF13475.6 EFC48072.1 - 9.1e-69 227.0 3.5 1e-13 50.8 0.0 11.0 7 4 1 10 10 10 10 Domain of unknown function (DUF4116) Band_7 PF01145.25 EFC48073.1 - 6.5e-30 104.5 0.5 6.5e-30 104.5 0.5 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 EFC48073.1 - 9.1e-25 86.5 1.0 2.3e-24 85.2 1.0 1.8 1 0 0 1 1 1 1 C-terminal region of band_7 Band_7_1 PF13421.6 EFC48073.1 - 0.00093 19.0 0.2 0.002 17.9 0.2 1.6 1 0 0 1 1 1 1 SPFH domain-Band 7 family TPR_19 PF14559.6 EFC48073.1 - 0.04 14.4 3.7 1.8 9.1 2.4 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Actin PF00022.19 EFC48075.1 - 7.4e-101 337.7 0.0 7.8e-56 189.4 0.0 2.3 1 1 1 2 2 2 2 Actin MPC PF03650.13 EFC48076.1 - 1.5e-32 112.0 0.1 1.6e-32 111.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers RGS PF00615.19 EFC48077.1 - 2e-09 37.7 0.6 3.8e-09 36.8 0.6 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC48077.1 - 5.2e-05 23.0 0.9 0.00018 21.3 0.9 2.0 1 1 0 1 1 1 1 Regulator of G protein signalling-like domain DUF5310 PF17237.2 EFC48077.1 - 0.033 14.1 0.6 2.2 8.2 0.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5310) FAM176 PF14851.6 EFC48078.1 - 0.0044 16.7 0.0 0.0061 16.2 0.0 1.2 1 0 0 1 1 1 1 FAM176 family SpoIIIAH PF12685.7 EFC48078.1 - 0.0096 15.8 1.0 0.012 15.4 1.0 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein DUF4006 PF13179.6 EFC48078.1 - 0.049 13.6 0.1 0.1 12.5 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF4006) Presenilin PF01080.17 EFC48078.1 - 0.28 9.9 1.5 0.34 9.6 1.5 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 EFC48078.1 - 0.4 11.7 6.9 0.83 10.7 6.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) CobT PF06213.12 EFC48078.1 - 1.1 8.6 9.7 1.4 8.3 9.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT OppC_N PF12911.7 EFC48078.1 - 1.2 9.2 0.0 1.2 9.2 0.0 2.5 2 1 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C API5 PF05918.11 EFC48078.1 - 1.9 7.2 8.3 2.3 7.0 8.3 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) LPAM_1 PF08139.12 EFC48078.1 - 1.9 9.1 5.3 2.7 8.7 5.3 1.1 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site HemX PF04375.14 EFC48078.1 - 2.6 7.3 10.2 3.2 7.0 10.2 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Rieske PF00355.26 EFC48079.1 - 1e-06 28.6 0.0 2.3e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EFC48079.1 - 0.00032 20.6 0.0 0.00082 19.3 0.0 1.6 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain RCC1_2 PF13540.6 EFC48080.1 - 6e-15 54.6 13.3 2.1e-06 27.4 0.1 5.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC48080.1 - 6.8e-11 42.6 3.0 0.022 15.3 0.1 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Peptidase_C25_C PF03785.14 EFC48080.1 - 0.036 13.9 0.1 11 5.9 0.0 2.8 1 1 1 2 2 2 0 Peptidase family C25, C terminal ig-like domain VWA_2 PF13519.6 EFC48081.1 - 1.4e-11 45.0 0.0 3.3e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 EFC48081.1 - 2.9e-09 37.4 0.0 5.3e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC48081.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain KRTAP PF11759.8 EFC48082.1 - 2.8e-07 31.0 90.3 0.0043 17.6 23.1 4.2 1 1 1 2 2 2 1 Keratin-associated matrix Keratin_2_head PF16208.5 EFC48082.1 - 0.059 13.5 88.2 1.8e+04 -48.7 88.2 4.3 1 1 0 1 1 1 0 Keratin type II head Sulf_transp PF04143.14 EFC48083.1 - 7.3e-63 213.0 14.6 8.6e-63 212.7 14.6 1.0 1 0 0 1 1 1 1 Sulphur transport DUF3172 PF11371.8 EFC48083.1 - 0.15 11.7 0.3 6.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) TMEM65 PF10507.9 EFC48083.1 - 0.4 10.7 5.0 2.4 8.1 0.1 3.5 3 1 1 4 4 4 0 Transmembrane protein 65 MVP_shoulder PF11978.8 EFC48084.1 - 1.9e-33 115.0 0.2 1.9e-33 115.0 0.2 1.9 2 0 0 2 2 2 1 Shoulder domain Vault_4 PF17796.1 EFC48084.1 - 8.4e-12 45.0 1.5 1.9e-09 37.4 0.1 3.5 3 0 0 3 3 3 1 Major Vault Protein repeat domain Vault_3 PF17795.1 EFC48084.1 - 3.1e-11 43.1 0.0 5.6e-07 29.5 0.0 3.9 5 0 0 5 5 5 2 Major Vault Protein Repeat domain Vault_2 PF17794.1 EFC48084.1 - 4.3e-06 27.0 0.0 2.5e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 Major Vault Protein repeat domain Band_7 PF01145.25 EFC48084.1 - 0.029 14.4 1.8 0.049 13.6 0.0 2.2 2 0 0 2 2 2 0 SPFH domain / Band 7 family RPN7 PF10602.9 EFC48084.1 - 0.032 13.9 1.0 0.032 13.9 1.0 2.3 2 0 0 2 2 2 0 26S proteasome subunit RPN7 Myosin_head PF00063.21 EFC48085.1 - 5.8e-255 847.7 11.4 5.8e-255 847.7 11.4 3.5 3 0 0 3 3 1 1 Myosin head (motor domain) Filament PF00038.21 EFC48085.1 - 5.6e-09 36.0 255.0 0.00025 20.8 21.1 10.9 1 1 9 10 10 10 7 Intermediate filament protein Myosin_N PF02736.19 EFC48085.1 - 2.2e-06 27.4 1.0 5.2e-06 26.2 1.0 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain DUF1664 PF07889.12 EFC48085.1 - 0.00034 20.6 10.2 0.00034 20.6 10.2 14.2 2 2 14 17 17 17 2 Protein of unknown function (DUF1664) Spc7 PF08317.11 EFC48085.1 - 0.00039 19.4 11.4 0.00039 19.4 11.4 10.6 2 1 10 12 12 12 5 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EFC48085.1 - 0.00063 19.8 31.2 0.00063 19.8 31.2 13.8 4 3 9 13 13 13 4 TPR/MLP1/MLP2-like protein MscS_porin PF12795.7 EFC48085.1 - 0.0026 17.3 37.2 0.0026 17.3 37.2 8.6 1 1 7 8 8 5 1 Mechanosensitive ion channel porin domain Fez1 PF06818.15 EFC48085.1 - 0.012 16.1 250.1 0.025 15.1 26.0 10.2 1 1 8 9 9 9 0 Fez1 Matrilin_ccoil PF10393.9 EFC48085.1 - 0.11 12.4 9.8 0.13 12.1 2.4 4.2 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin IQ PF00612.27 EFC48085.1 - 0.11 12.3 0.7 12 6.0 0.0 2.6 2 0 0 2 2 2 0 IQ calmodulin-binding motif AAA_22 PF13401.6 EFC48085.1 - 0.15 12.3 0.1 0.15 12.3 0.1 6.1 5 2 0 5 5 4 0 AAA domain Myosin_tail_1 PF01576.19 EFC48085.1 - 2.9 5.6 274.7 3.5 5.3 121.7 4.3 1 1 2 3 3 3 0 Myosin tail FlaC_arch PF05377.11 EFC48086.1 - 0.05 14.0 1.1 0.11 12.9 1.1 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Menin PF05053.13 EFC48087.1 - 6.3 5.0 12.5 3.6 5.8 2.6 2.2 2 0 0 2 2 2 0 Menin DUF1180 PF06679.12 EFC48087.1 - 8.1 6.8 8.3 22 5.4 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) WD40 PF00400.32 EFC48089.1 - 0.026 15.4 0.0 0.52 11.3 0.0 3.2 3 1 0 3 3 3 0 WD domain, G-beta repeat Got1 PF04178.12 EFC48090.1 - 3.3e-12 46.8 13.2 4.4e-12 46.4 13.2 1.2 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2157 PF09925.9 EFC48090.1 - 1.8 8.3 5.6 3.1 7.6 5.4 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Acetyltransf_13 PF13880.6 EFC48091.1 - 1.4e-27 95.5 0.0 2.3e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 EFC48091.1 - 2.4e-15 56.0 4.7 3.6e-15 55.5 3.0 2.3 2 0 0 2 2 2 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_7 PF13508.7 EFC48091.1 - 0.00051 20.4 0.0 0.0023 18.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC48091.1 - 0.0022 18.2 0.0 0.0045 17.2 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC48091.1 - 0.005 16.8 0.0 0.67 9.9 0.0 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC48091.1 - 0.15 12.2 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CEP76-C2 PF15627.6 EFC48093.1 - 1e-42 145.4 0.0 1.7e-42 144.6 0.0 1.3 1 0 0 1 1 1 1 CEP76 C2 domain F-box-like PF12937.7 EFC48094.1 - 3.5e-05 23.6 0.5 7.2e-05 22.6 0.5 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48094.1 - 0.062 13.2 0.5 0.15 11.9 0.5 1.6 1 0 0 1 1 1 0 F-box domain DOMON PF03351.17 EFC48095.1 - 0.0013 18.9 0.2 0.0027 17.9 0.2 1.5 1 1 0 1 1 1 1 DOMON domain m04gp34like PF12216.8 EFC48095.1 - 0.22 11.1 0.1 0.22 11.1 0.1 1.4 2 0 0 2 2 2 0 Immune evasion protein Glyco_transf_8 PF01501.20 EFC48096.1 - 0.27 10.8 2.3 0.57 9.7 2.3 1.8 1 1 0 1 1 1 0 Glycosyl transferase family 8 APH PF01636.23 EFC48097.1 - 2.9e-10 40.5 0.0 5e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC48097.1 - 0.00057 19.5 2.2 0.00057 19.5 2.2 2.4 3 0 0 3 3 3 1 Choline/ethanolamine kinase DUF1679 PF07914.11 EFC48097.1 - 0.00082 18.3 1.5 0.0013 17.7 1.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) HSBP1 PF06825.12 EFC48097.1 - 0.69 9.8 3.5 21 5.1 0.4 3.2 3 0 0 3 3 3 0 Heat shock factor binding protein 1 RGS PF00615.19 EFC48099.1 - 0.039 14.2 0.0 0.069 13.4 0.0 1.5 1 0 0 1 1 1 0 Regulator of G protein signaling domain DUF167 PF02594.16 EFC48100.1 - 1e-24 86.4 0.1 1.1e-24 86.3 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 RhoGEF PF00621.20 EFC48101.1 - 1.4e-32 113.4 3.9 1.4e-32 113.4 3.9 1.8 2 0 0 2 2 2 1 RhoGEF domain Abhydrolase_3 PF07859.13 EFC48102.1 - 4.7e-19 69.1 0.0 6.4e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC48102.1 - 8.6e-14 51.2 0.2 1.3e-13 50.6 0.2 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 EFC48102.1 - 0.0025 17.1 0.0 0.0043 16.3 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S10 PF00450.22 EFC48102.1 - 0.012 15.1 0.2 0.02 14.3 0.0 1.4 2 0 0 2 2 2 0 Serine carboxypeptidase Abhydrolase_1 PF00561.20 EFC48102.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF900 PF05990.12 EFC48102.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Antistasin PF02822.14 EFC48103.1 - 9.7e-12 45.3 28.1 2e-07 31.5 11.0 2.4 2 0 0 2 2 2 2 Antistasin family zf-C3HC4_2 PF13923.6 EFC48103.1 - 5.2 7.0 17.4 0.16 11.8 11.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Antimicrobial25 PF16839.5 EFC48103.1 - 7.1 6.8 23.2 0.9 9.7 7.5 2.5 2 1 0 2 2 2 0 Nematode antimicrobial peptide Vta1 PF04652.16 EFC48104.1 - 9.6e-43 145.6 1.7 9.6e-43 145.6 1.7 1.9 3 0 0 3 3 3 1 Vta1 like Vta1_C PF18097.1 EFC48104.1 - 3.1e-17 62.0 3.4 4.4e-17 61.5 0.4 2.3 2 0 0 2 2 2 1 Vta1 C-terminal domain Closter_coat PF01785.17 EFC48104.1 - 0.0033 16.7 0.3 0.0083 15.4 0.3 1.6 1 0 0 1 1 1 1 Closterovirus coat protein ANAPC8 PF04049.13 EFC48104.1 - 0.78 9.8 4.3 1.1 9.3 0.9 2.4 1 1 0 2 2 2 0 Anaphase promoting complex subunit 8 / Cdc23 DUF302 PF03625.14 EFC48105.1 - 4.1e-10 39.4 0.1 6.6e-10 38.7 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF302 CN_hydrolase PF00795.22 EFC48107.1 - 3.4e-12 46.2 0.0 5.2e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF5626 PF18540.1 EFC48107.1 - 0.13 12.8 3.6 0.1 13.1 1.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5626) DUF1454 PF07305.12 EFC48107.1 - 0.15 11.5 0.0 0.33 10.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1454) YdjM PF04307.14 EFC48108.1 - 1.1e-05 24.8 1.5 1.8e-05 24.1 1.5 1.5 1 0 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase UbiA PF01040.18 EFC48109.1 - 8e-44 149.8 3.2 1.1e-43 149.3 3.1 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Takusan PF04822.13 EFC48109.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Takusan DNA_pol_E_B PF04042.16 EFC48110.1 - 4.7e-38 130.6 3.9 7.7e-38 130.0 3.9 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF3659 PF12396.8 EFC48110.1 - 0.065 13.2 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) ORF6C PF10552.9 EFC48114.1 - 0.33 11.1 5.7 0.87 9.7 2.0 2.9 2 0 0 2 2 2 0 ORF6C domain Ras PF00071.22 EFC48115.1 - 7.8e-07 28.8 0.4 8.1e-07 28.8 0.4 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC48115.1 - 8.8e-05 22.0 0.5 9.2e-05 22.0 0.5 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC48115.1 - 0.0026 17.9 0.0 0.0031 17.7 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SlyX PF04102.12 EFC48116.1 - 0.0098 16.5 0.1 0.022 15.4 0.1 1.6 1 0 0 1 1 1 1 SlyX GIT_CC PF16559.5 EFC48116.1 - 0.063 13.2 0.9 0.15 12.0 0.8 1.7 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TPR_17 PF13431.6 EFC48118.1 - 0.02 15.2 0.1 15 6.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48118.1 - 0.05 13.7 4.5 8.9 6.7 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48118.1 - 0.4 11.2 2.9 2.3 8.8 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat LRR_6 PF13516.6 EFC48120.1 - 1.7e-19 68.1 17.8 0.0002 21.1 0.7 5.9 6 0 0 6 6 6 4 Leucine Rich repeat LRR_4 PF12799.7 EFC48120.1 - 3e-10 40.2 33.8 0.00017 21.9 8.1 5.6 5 1 1 6 6 6 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC48120.1 - 0.00048 19.7 8.8 0.049 13.1 0.3 3.2 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 EFC48120.1 - 0.0018 18.6 23.4 1.1 10.0 0.6 7.0 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_8 PF13855.6 EFC48120.1 - 0.09 12.6 32.0 0.96 9.3 10.4 5.7 2 2 1 3 3 3 0 Leucine rich repeat YdiH PF15930.5 EFC48120.1 - 0.15 12.3 0.0 9.9 6.4 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function LRR_8 PF13855.6 EFC48121.1 - 4e-19 68.1 39.0 1.3e-08 34.5 8.4 4.8 4 1 0 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EFC48121.1 - 1.5e-18 65.2 37.2 0.0019 18.1 0.6 9.6 11 0 0 11 11 11 5 Leucine Rich repeat LRR_4 PF12799.7 EFC48121.1 - 2.6e-12 46.7 54.0 0.00066 20.0 3.4 7.6 3 2 4 7 7 7 6 Leucine Rich repeats (2 copies) PrgU PF09627.10 EFC48121.1 - 0.00014 21.7 0.4 0.86 9.6 0.0 2.8 2 0 0 2 2 2 2 PrgU-like protein LRR_9 PF14580.6 EFC48121.1 - 0.00025 20.6 15.8 0.23 11.0 2.4 3.8 1 1 2 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EFC48121.1 - 0.00081 19.6 24.7 8.7 7.3 0.5 8.4 8 2 1 9 9 9 4 Leucine Rich Repeat EamA PF00892.20 EFC48122.1 - 1.8e-26 92.9 40.3 7.7e-14 52.0 16.5 3.1 2 1 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 EFC48122.1 - 0.16 10.8 19.8 0.39 9.6 4.9 3.6 2 1 1 4 4 4 0 CRT-like, chloroquine-resistance transporter-like Gram_pos_anchor PF00746.21 EFC48122.1 - 0.23 11.4 2.4 1.1 9.3 0.2 2.7 2 0 0 2 2 2 0 LPXTG cell wall anchor motif TMEM234 PF10639.9 EFC48122.1 - 0.24 11.4 11.4 0.11 12.6 0.7 2.9 3 0 0 3 3 3 0 Putative transmembrane family 234 Claudin_2 PF13903.6 EFC48122.1 - 0.9 9.3 10.7 4.6 6.9 4.0 3.8 3 1 1 4 4 4 0 PMP-22/EMP/MP20/Claudin tight junction RGS PF00615.19 EFC48123.1 - 0.00023 21.4 2.2 0.00051 20.3 2.2 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain SNase PF00565.17 EFC48124.1 - 1.1e-28 99.9 0.1 1.3e-28 99.6 0.1 1.0 1 0 0 1 1 1 1 Staphylococcal nuclease homologue DUF2833 PF11090.8 EFC48124.1 - 0.037 14.4 0.1 0.098 13.1 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2833) Ribosomal_L18p PF00861.22 EFC48124.1 - 0.12 12.8 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Pkinase PF00069.25 EFC48125.1 - 5.8e-54 183.2 0.4 8.4e-54 182.7 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48125.1 - 2.5e-31 108.9 0.0 4.4e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC48125.1 - 9.1e-27 91.7 14.3 0.00038 20.4 0.0 10.7 10 0 0 10 10 10 6 NHL repeat EGF_2 PF07974.13 EFC48125.1 - 1.8e-24 85.7 105.6 0.0002 21.7 5.4 7.6 7 0 0 7 7 7 7 EGF-like domain Pkinase_fungal PF17667.1 EFC48125.1 - 2.6e-05 23.2 0.2 6.7e-05 21.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase SGL PF08450.12 EFC48125.1 - 0.00032 20.3 1.9 0.0035 17.0 0.9 3.7 2 2 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region EGF PF00008.27 EFC48125.1 - 0.0016 18.7 79.0 0.034 14.4 4.6 7.7 7 0 0 7 7 7 4 EGF-like domain Haspin_kinase PF12330.8 EFC48125.1 - 0.0018 17.3 0.0 0.0033 16.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFC48125.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Chordopox_A13L PF05961.11 EFC48125.1 - 0.079 13.2 1.3 0.34 11.2 0.2 2.4 2 0 0 2 2 2 0 Chordopoxvirus A13L protein TMEM154 PF15102.6 EFC48125.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family CsgG PF03783.14 EFC48125.1 - 0.24 10.7 3.9 1.3 8.2 0.1 3.0 2 1 1 3 3 3 0 Curli production assembly/transport component CsgG DUF3149 PF11346.8 EFC48125.1 - 2.6 7.7 5.7 6.5 6.5 5.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) 2-oxoacid_dh PF00198.23 EFC48127.1 - 7.9e-84 280.7 0.0 1e-83 280.3 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFC48127.1 - 1.2e-15 57.1 0.3 4e-15 55.4 0.0 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 EFC48127.1 - 8.1e-12 45.3 1.6 1.2e-11 44.8 0.0 2.2 2 0 0 2 2 2 1 e3 binding domain Intein_splicing PF14890.6 EFC48127.1 - 0.18 11.8 1.5 0.87 9.5 1.0 2.2 1 1 0 1 1 1 0 Intein splicing domain DUF4680 PF15730.5 EFC48127.1 - 2.9 8.2 6.8 16 5.9 4.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) BAT2_N PF07001.11 EFC48127.1 - 4.7 7.6 11.2 9.3 6.7 11.2 1.5 1 0 0 1 1 1 0 BAT2 N-terminus Acyltransferase PF01553.21 EFC48128.1 - 6e-18 64.8 0.0 8.5e-18 64.3 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase DUF3848 PF12959.7 EFC48129.1 - 0.026 14.6 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) DUF421 PF04239.12 EFC48129.1 - 0.13 12.0 0.1 0.28 11.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF421) AgrB PF04647.15 EFC48130.1 - 0.0098 15.2 11.7 0.016 14.5 11.7 1.2 1 0 0 1 1 1 1 Accessory gene regulator B Zn_clus PF00172.18 EFC48131.1 - 1.3e-06 28.5 11.3 3.2e-06 27.2 11.3 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Thioredoxin PF00085.20 EFC48132.1 - 2.5e-28 98.1 0.0 2.8e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 EFC48132.1 - 3.7e-07 30.6 0.0 1e-05 25.9 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFC48132.1 - 1.7e-05 25.1 0.0 2.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 EFC48132.1 - 0.0025 17.6 0.0 0.0026 17.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 EFC48132.1 - 0.0043 17.0 0.1 0.0083 16.0 0.0 1.4 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_7 PF13899.6 EFC48132.1 - 0.0074 16.4 0.1 0.014 15.5 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 EFC48132.1 - 0.0096 15.6 0.1 0.014 15.1 0.1 1.3 1 1 0 1 1 1 1 Redoxin OST3_OST6 PF04756.13 EFC48132.1 - 0.017 14.5 0.0 0.019 14.3 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Rho_N PF07498.12 EFC48133.1 - 0.0066 16.3 1.2 0.014 15.3 1.2 1.6 1 0 0 1 1 1 1 Rho termination factor, N-terminal domain DUF5611 PF18446.1 EFC48133.1 - 2.5 9.0 7.9 0.38 11.6 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5611) DUF4116 PF13475.6 EFC48134.1 - 1.1e-68 226.7 33.2 1.4e-12 47.1 0.1 10.6 6 4 3 10 10 10 10 Domain of unknown function (DUF4116) CHCH PF06747.13 EFC48135.1 - 0.071 13.3 1.8 0.12 12.6 0.4 2.1 2 0 0 2 2 2 0 CHCH domain PapG_N PF03627.13 EFC48135.1 - 0.089 12.5 0.2 0.13 11.9 0.1 1.4 1 1 0 1 1 1 0 PapG carbohydrate binding domain PP2C PF00481.21 EFC48137.1 - 4.8e-37 128.0 2.3 3.5e-30 105.5 0.0 3.4 4 0 0 4 4 4 2 Protein phosphatase 2C IMS PF00817.20 EFC48137.1 - 0.011 15.8 0.0 0.026 14.5 0.0 1.6 1 0 0 1 1 1 0 impB/mucB/samB family SAD_SRA PF02182.17 EFC48138.1 - 9.1e-37 126.2 0.3 2.6e-36 124.7 0.3 1.8 1 0 0 1 1 1 1 SAD/SRA domain Ldh_1_N PF00056.23 EFC48140.1 - 2.5e-32 111.9 0.1 6.6e-32 110.5 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 EFC48140.1 - 1.2e-30 106.7 0.0 2.4e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF1829 PF08862.10 EFC48141.1 - 0.0072 16.8 0.3 0.026 15.0 0.3 2.0 1 0 0 1 1 1 1 Domain of unknown function DUF1829 MFS_5 PF05631.14 EFC48142.1 - 7e-98 327.8 19.8 1e-97 327.3 19.8 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 EFC48142.1 - 4.2e-17 62.1 35.3 1.2e-10 40.8 8.1 2.7 3 1 0 3 3 3 2 Major Facilitator Superfamily NDUF_B6 PF09782.9 EFC48142.1 - 0.25 11.5 1.0 1 9.5 0.2 2.3 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Tnp_zf-ribbon_2 PF13842.6 EFC48143.1 - 1.3 9.9 3.1 2.5 9.0 3.1 1.5 1 0 0 1 1 1 0 DDE_Tnp_1-like zinc-ribbon zf-B_box PF00643.24 EFC48143.1 - 4.8 7.4 6.9 12 6.1 6.9 1.6 1 1 0 1 1 1 0 B-box zinc finger Pkinase PF00069.25 EFC48144.1 - 4.8e-45 154.0 0.5 7.9e-45 153.3 0.5 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48144.1 - 1.3e-29 103.3 0.2 2.1e-29 102.6 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Shisa PF13908.6 EFC48144.1 - 0.00054 20.3 0.9 0.0013 19.1 0.9 1.7 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Kdo PF06293.14 EFC48144.1 - 0.014 14.7 0.1 0.025 14.0 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ly49 PF08391.10 EFC48144.1 - 0.052 13.9 0.3 0.3 11.5 0.1 2.4 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region EphA2_TM PF14575.6 EFC48144.1 - 0.06 14.2 0.0 0.17 12.8 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain PIG-F PF06699.11 EFC48145.1 - 1.5e-10 41.5 8.1 1.9e-10 41.2 1.2 2.6 2 1 0 2 2 2 1 GPI biosynthesis protein family Pig-F ECF_trnsprt PF12822.7 EFC48145.1 - 0.18 11.9 13.8 0.38 10.8 0.2 2.4 2 1 0 2 2 2 0 ECF transporter, substrate-specific component Metallothio_11 PF02066.15 EFC48145.1 - 0.52 10.5 2.5 1.2 9.3 0.4 2.4 2 0 0 2 2 2 0 Metallothionein family 11 PAP2_C PF14360.6 EFC48146.1 - 3.5e-18 65.9 12.6 1.1e-17 64.3 10.1 2.8 2 1 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 EFC48146.1 - 2.3e-06 27.4 4.2 2.3e-06 27.4 4.2 1.7 1 1 1 2 2 2 1 PAP2 superfamily ATP-synt_I PF03899.15 EFC48146.1 - 0.00048 20.5 0.1 0.00048 20.5 0.1 2.6 2 1 0 3 3 3 1 ATP synthase I chain Cyclin_N PF00134.23 EFC48147.1 - 5.1e-40 136.1 1.2 8.2e-39 132.2 0.3 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC48147.1 - 9.4e-21 74.1 1.3 3.7e-19 68.9 0.2 2.9 2 1 1 3 3 3 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 EFC48147.1 - 0.044 14.2 0.3 0.13 12.7 0.2 2.0 1 1 0 1 1 1 0 Cyclin C-terminal domain AAA_14 PF13173.6 EFC48148.1 - 0.083 12.9 2.9 0.13 12.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain zf-C2H2_assoc PF16606.5 EFC48148.1 - 0.8 10.0 3.5 1.2 9.4 0.3 2.1 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers Pkinase PF00069.25 EFC48149.1 - 3.8e-53 180.5 1.4 4.7e-53 180.2 1.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48149.1 - 3.4e-32 111.7 0.2 4e-32 111.5 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC48149.1 - 0.00013 20.8 0.0 0.00026 19.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC48149.1 - 0.0065 16.4 0.1 0.01 15.8 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 EFC48149.1 - 0.01 15.2 0.0 2.6 7.3 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Sde2_N_Ubi PF13019.6 EFC48149.1 - 0.033 14.0 0.6 0.069 13.0 0.1 1.7 2 0 0 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain Kdo PF06293.14 EFC48149.1 - 0.18 11.2 0.4 0.72 9.2 0.2 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family NHL PF01436.21 EFC48150.1 - 8e-26 88.7 0.0 0.00015 21.6 0.0 10.2 10 0 0 10 10 10 5 NHL repeat EGF_2 PF07974.13 EFC48150.1 - 4.9e-11 42.8 71.4 0.0013 19.0 10.2 6.2 5 0 0 5 5 5 4 EGF-like domain BcrAD_BadFG PF01869.20 EFC48150.1 - 0.17 11.4 3.6 0.63 9.5 0.2 2.6 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Redoxin PF08534.10 EFC48151.1 - 2.2e-31 108.5 0.1 2.7e-31 108.3 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 EFC48151.1 - 1.4e-08 34.7 0.0 1.9e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family TerD PF02342.18 EFC48152.1 - 5.8e-20 71.6 2.9 1.1e-08 34.8 0.1 3.9 4 0 0 4 4 4 3 TerD domain C2 PF00168.30 EFC48152.1 - 1.5e-15 57.3 0.1 6.1e-15 55.4 0.0 2.1 2 0 0 2 2 2 1 C2 domain NUFIP1 PF10453.9 EFC48153.1 - 1.3e-12 47.4 7.2 1.3e-12 47.4 7.2 2.5 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Myosin_head PF00063.21 EFC48154.1 - 7.4e-210 698.6 11.3 7.4e-210 698.6 11.3 3.1 3 2 1 4 4 4 1 Myosin head (motor domain) AAA_22 PF13401.6 EFC48154.1 - 0.023 15.0 0.0 0.023 15.0 0.0 3.6 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFC48154.1 - 0.027 14.9 0.4 0.22 11.9 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.6 EFC48154.1 - 0.061 13.7 0.0 0.061 13.7 0.0 3.9 2 1 2 4 4 4 0 AAA ATPase domain DEAD PF00270.29 EFC48155.1 - 4.6e-46 156.8 0.0 2e-45 154.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC48155.1 - 1.3e-34 118.9 0.0 1e-32 112.7 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC48155.1 - 0.0075 16.3 0.0 0.017 15.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit EB PF01683.18 EFC48157.1 - 0.41 11.0 74.3 0.088 13.1 7.1 8.6 2 2 5 7 7 7 0 EB module Aminotran_4 PF01063.19 EFC48158.1 - 3.9e-13 49.8 0.2 1.6e-12 47.8 0.2 2.0 1 1 0 1 1 1 1 Amino-transferase class IV DUF334 PF03904.13 EFC48159.1 - 0.00018 21.2 0.3 0.00028 20.5 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF334) FPP PF05911.11 EFC48159.1 - 0.0021 16.3 2.6 0.0021 16.3 2.6 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Filament PF00038.21 EFC48159.1 - 0.0085 15.7 1.7 0.012 15.2 1.7 1.2 1 0 0 1 1 1 1 Intermediate filament protein Phlebovirus_NSM PF07246.11 EFC48159.1 - 0.013 14.9 0.8 0.03 13.7 0.8 1.5 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M CENP-K PF11802.8 EFC48159.1 - 0.013 15.1 1.9 0.017 14.7 1.9 1.1 1 0 0 1 1 1 0 Centromere-associated protein K SHE3 PF17078.5 EFC48159.1 - 0.014 15.2 3.2 0.02 14.6 3.2 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Seryl_tRNA_N PF02403.22 EFC48159.1 - 0.019 15.2 2.6 0.034 14.4 2.6 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 EFC48159.1 - 0.022 15.0 2.1 0.024 14.9 2.1 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 EFC48159.1 - 0.044 14.0 2.7 0.072 13.3 2.7 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family IFP_35_N PF07334.13 EFC48159.1 - 0.051 13.7 2.2 0.063 13.4 0.9 1.8 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Cnn_1N PF07989.11 EFC48159.1 - 0.054 13.7 3.8 0.11 12.7 3.8 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF5082 PF16888.5 EFC48159.1 - 0.058 13.7 4.2 0.2 11.9 2.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) L31 PF09784.9 EFC48159.1 - 0.09 13.2 0.2 0.15 12.5 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 DUF5595 PF18077.1 EFC48159.1 - 0.11 12.6 2.4 0.18 11.9 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Pox_A_type_inc PF04508.12 EFC48159.1 - 0.15 11.9 3.1 0.83 9.6 3.1 2.2 1 1 0 1 1 1 0 Viral A-type inclusion protein repeat Fer4_5 PF12801.7 EFC48159.1 - 0.16 11.9 1.7 0.33 10.9 1.7 1.5 1 0 0 1 1 1 0 4Fe-4S binding domain DUF2207 PF09972.9 EFC48159.1 - 0.22 10.2 3.1 0.066 12.0 0.5 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Flp1_like PF16982.5 EFC48159.1 - 0.51 9.8 5.5 1.2 8.6 5.5 1.7 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain DUF4140 PF13600.6 EFC48159.1 - 0.79 10.2 4.8 3.5 8.1 4.0 2.2 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) DUF641 PF04859.12 EFC48159.1 - 0.84 10.0 5.6 2 8.8 5.6 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) ZapB PF06005.12 EFC48159.1 - 0.87 10.1 7.0 1.1 9.8 5.5 1.8 1 1 1 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 EFC48159.1 - 1.1 9.1 10.8 0.058 13.2 3.6 2.4 3 0 0 3 3 3 0 Septum formation initiator MPS2 PF17060.5 EFC48159.1 - 2.9 7.1 9.1 2.5 7.3 6.9 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 CENP-H PF05837.12 EFC48159.1 - 3.4 8.1 7.7 1.2 9.6 4.4 1.8 2 1 1 3 3 2 0 Centromere protein H (CENP-H) TSC22 PF01166.18 EFC48159.1 - 3.6 8.0 6.3 1.6 9.1 2.1 2.3 2 1 1 3 3 2 0 TSC-22/dip/bun family T2SSF PF00482.23 EFC48159.1 - 4.5 7.2 7.4 2.9 7.9 0.0 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF846 PF05832.12 EFC48160.1 - 7.4e-52 175.1 21.9 8.2e-52 174.9 21.9 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) DUF805 PF05656.14 EFC48160.1 - 0.69 10.3 7.8 1.1 9.7 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF805) SdpI PF13630.6 EFC48160.1 - 6.3 7.0 10.6 1.6 8.9 1.1 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF1501 PF07394.12 EFC48161.1 - 0.13 11.3 4.3 0.081 12.0 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) Jnk-SapK_ap_N PF09744.9 EFC48161.1 - 0.24 11.6 16.3 0.6 10.3 10.5 2.5 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 SIKE PF05769.11 EFC48161.1 - 1.4 8.8 23.1 0.44 10.5 19.3 2.1 2 0 0 2 2 2 0 SIKE family Methyltransf_3 PF01596.17 EFC48162.1 - 2.3e-55 187.0 0.2 2.8e-55 186.8 0.2 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EFC48162.1 - 3.8e-13 50.4 0.0 6.6e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC48162.1 - 2.1e-07 30.9 0.0 2.9e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC48162.1 - 2.9e-06 27.9 0.0 5.5e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFC48162.1 - 4.6e-06 26.6 0.0 8.1e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFC48162.1 - 7.1e-05 22.2 0.0 9.9e-05 21.8 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 EFC48162.1 - 0.00092 19.8 0.0 0.0021 18.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC48162.1 - 0.0018 17.7 0.0 0.0028 17.0 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 EFC48162.1 - 0.0019 17.9 0.0 0.0026 17.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PCMT PF01135.19 EFC48162.1 - 0.013 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 EFC48162.1 - 0.024 14.5 0.0 0.043 13.6 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 EFC48162.1 - 0.029 13.9 0.0 0.078 12.5 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 EFC48162.1 - 0.035 14.1 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 EFC48162.1 - 0.16 12.7 0.1 1 10.1 0.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain SRPRB PF09439.10 EFC48163.1 - 1e-29 103.3 1.6 1.3e-29 102.9 1.6 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EFC48163.1 - 1.4e-11 44.1 0.3 2e-11 43.6 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC48163.1 - 3.5e-05 23.9 0.1 6.5e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 EFC48163.1 - 0.00094 19.4 0.0 0.0016 18.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF3881 PF12997.7 EFC48163.1 - 0.017 14.4 0.0 0.18 11.0 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function, E. rectale Gene description (DUF3881) Dynamin_N PF00350.23 EFC48163.1 - 0.039 14.0 0.7 0.077 13.1 0.1 1.8 1 1 1 2 2 2 0 Dynamin family VWA_N PF08399.11 EFC48163.1 - 0.11 13.0 0.3 0.98 9.9 0.1 2.0 2 0 0 2 2 2 0 VWA N-terminal AAA_14 PF13173.6 EFC48163.1 - 0.12 12.4 2.9 0.37 10.8 0.1 2.5 1 1 1 3 3 3 0 AAA domain FeoB_associated PF12669.7 EFC48163.1 - 0.28 11.6 1.0 0.52 10.7 1.0 1.4 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein FtsJ PF01728.19 EFC48164.1 - 1.2e-35 123.2 0.0 2.3e-35 122.3 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase G-patch PF01585.23 EFC48164.1 - 3.5e-12 46.0 4.0 6.6e-12 45.1 4.0 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFC48164.1 - 0.00016 21.7 1.1 0.00016 21.7 1.1 1.8 2 0 0 2 2 2 1 G-patch domain RLL PF10036.9 EFC48164.1 - 0.0072 16.2 5.4 0.015 15.2 5.4 1.4 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein DUF601 PF04642.12 EFC48164.1 - 0.01 15.4 2.0 0.017 14.7 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF601 GFRP PF06399.13 EFC48164.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) DEAD PF00270.29 EFC48166.1 - 1.8e-43 148.3 0.6 4.6e-43 147.0 0.4 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC48166.1 - 6.4e-25 87.7 2.2 2.1e-24 86.0 0.0 2.9 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC48166.1 - 1.3e-05 25.3 0.1 1.3e-05 25.3 0.1 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Pox_TAP PF03355.14 EFC48166.1 - 0.018 14.6 0.1 0.03 13.9 0.1 1.3 1 0 0 1 1 1 0 Viral Trans-Activator Protein ERCC3_RAD25_C PF16203.5 EFC48166.1 - 0.023 13.9 0.0 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 EFC48166.1 - 0.047 14.0 0.3 0.17 12.2 0.2 2.1 1 1 1 2 2 2 0 AAA domain Helicase_RecD PF05127.14 EFC48166.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Helicase Cyclin_N PF00134.23 EFC48167.1 - 5e-12 45.7 2.0 4.1e-09 36.3 0.5 2.3 2 1 0 2 2 2 2 Cyclin, N-terminal domain TFIIB PF00382.19 EFC48167.1 - 0.033 14.2 0.1 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 Transcription factor TFIIB repeat DUF1741 PF08427.10 EFC48169.1 - 2.9e-46 158.0 3.5 5.2e-46 157.2 3.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) IFRD PF05004.13 EFC48169.1 - 0.033 13.3 1.9 0.42 9.7 0.1 3.2 4 0 0 4 4 4 0 Interferon-related developmental regulator (IFRD) IQ PF00612.27 EFC48170.1 - 5.4e-10 38.2 14.7 0.0094 15.7 0.6 3.9 3 0 0 3 3 3 3 IQ calmodulin-binding motif Octopine_DH PF02317.17 EFC48170.1 - 0.028 14.5 0.4 0.052 13.6 0.4 1.5 1 0 0 1 1 1 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain Tau95 PF09734.9 EFC48171.1 - 7.5e-47 159.7 0.8 2.6e-46 157.9 0.8 2.0 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 EFC48171.1 - 7.6e-27 94.0 0.1 7.6e-27 94.0 0.1 3.1 4 0 0 4 4 4 1 Tau95 Triple barrel domain DUF4096 PF13340.6 EFC48171.1 - 0.085 13.1 0.3 0.17 12.1 0.3 1.5 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) LRR_8 PF13855.6 EFC48172.1 - 5.7e-13 48.4 11.0 1.2e-08 34.6 1.8 2.8 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 EFC48172.1 - 5.2e-05 23.5 12.9 0.0069 16.8 3.4 3.7 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC48172.1 - 0.96 9.7 5.6 1.3 9.3 0.1 3.6 4 0 0 4 4 4 0 Leucine Rich repeat DAG_kinase_N PF14513.6 EFC48172.1 - 1.8 8.8 11.6 0.064 13.5 1.6 2.7 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Abhydrolase_3 PF07859.13 EFC48173.1 - 1.1e-47 162.6 0.0 1.7e-47 162.1 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC48173.1 - 3.8e-08 32.6 0.0 8.1e-08 31.5 0.0 1.5 1 0 0 1 1 1 1 Steryl acetyl hydrolase HSL_N PF06350.12 EFC48173.1 - 2.4e-07 30.1 1.3 4e-07 29.3 1.3 1.3 1 0 0 1 1 1 1 Hormone-sensitive lipase (HSL) N-terminus Chlorophyllase2 PF12740.7 EFC48173.1 - 0.054 12.4 0.0 0.12 11.2 0.0 1.6 1 0 0 1 1 1 0 Chlorophyllase enzyme Pinin_SDK_memA PF04696.13 EFC48174.1 - 3.4 7.7 15.7 1.2 9.2 8.2 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region ER_lumen_recept PF00810.18 EFC48175.1 - 1e-53 182.1 12.4 1.7e-53 181.4 12.4 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 EFC48175.1 - 0.55 10.0 8.7 0.82 9.5 0.5 3.3 2 1 0 2 2 2 0 PQ loop repeat Cpn60_TCP1 PF00118.24 EFC48176.1 - 1.3e-85 288.0 17.4 7.1e-85 285.5 17.4 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family SRP54_N PF02881.19 EFC48176.1 - 0.097 12.9 1.6 4.2 7.7 0.0 3.3 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain cwf21 PF08312.12 EFC48176.1 - 0.77 10.0 0.1 0.77 10.0 0.1 2.8 3 0 0 3 3 3 0 cwf21 domain LRR_4 PF12799.7 EFC48177.1 - 7.8e-21 73.8 43.7 7.3e-07 29.4 0.4 6.7 3 1 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC48177.1 - 2.4e-19 69.5 20.2 2.2e-12 46.8 5.4 3.3 2 1 1 3 3 3 3 Leucine-rich repeat LRR_8 PF13855.6 EFC48177.1 - 7.1e-14 51.3 41.2 8.2e-06 25.5 6.7 6.2 3 1 1 5 5 5 4 Leucine rich repeat LRR_3 PF07725.12 EFC48177.1 - 5.3 7.1 5.8 37 4.4 0.4 4.0 3 0 0 3 3 3 0 Leucine Rich Repeat CLAMP PF14769.6 EFC48179.1 - 8.6e-12 45.4 1.7 6.7e-08 32.9 0.0 2.8 3 0 0 3 3 2 2 Flagellar C1a complex subunit C1a-32 Vfa1 PF08432.10 EFC48179.1 - 0.3 11.4 32.1 0.09 13.1 13.1 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 GBP_C PF02841.14 EFC48179.1 - 0.4 10.0 39.1 0.2 11.0 12.7 2.1 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain Ctr PF04145.15 EFC48179.1 - 1.4 9.5 5.4 2.3 8.8 0.3 2.4 2 0 0 2 2 2 0 Ctr copper transporter family Cytochrom_C PF00034.21 EFC48179.1 - 2.3 9.4 11.1 0.78 10.9 2.1 2.6 2 1 1 3 3 3 0 Cytochrome c Connexin PF00029.19 EFC48179.1 - 2.6 7.8 19.7 1.4 8.6 6.1 2.3 2 0 0 2 2 2 0 Connexin CDC45 PF02724.14 EFC48179.1 - 3.3 5.9 29.5 0.29 9.4 12.4 2.1 2 0 0 2 2 2 0 CDC45-like protein Asp-B-Hydro_N PF05279.11 EFC48179.1 - 3.5 7.6 39.0 1.4 8.9 11.4 2.2 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region Eapp_C PF10238.9 EFC48179.1 - 4.4 7.4 19.3 2.6 8.1 6.7 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein Tim54 PF11711.8 EFC48179.1 - 4.5 5.9 25.6 0.36 9.6 8.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 AIF_C PF14721.6 EFC48179.1 - 5.5 7.4 20.3 5.6 7.3 3.4 2.6 2 1 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CSG2 PF16965.5 EFC48179.1 - 5.8 5.7 11.4 3.7 6.4 2.4 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator TFB6 PF17110.5 EFC48179.1 - 7.1 6.3 16.7 1 9.1 4.2 2.5 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CENP-N PF05238.13 EFC48179.1 - 8 5.7 24.9 4.6 6.4 8.3 3.0 3 0 0 3 3 3 0 Kinetochore protein CHL4 like DUF4355 PF14265.6 EFC48179.1 - 8.6 6.6 46.6 3.2 8.0 18.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) RR_TM4-6 PF06459.12 EFC48179.1 - 9.4 6.0 35.6 2.6 7.8 15.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TBCC PF07986.12 EFC48181.1 - 1.3e-31 108.9 1.4 2.1e-31 108.1 1.4 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 EFC48181.1 - 2.1e-07 31.3 8.7 1.6e-05 25.3 8.6 2.5 1 1 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain FAD_oxidored PF12831.7 EFC48181.1 - 0.17 11.2 0.8 0.24 10.7 0.8 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NMO PF03060.15 EFC48181.1 - 0.29 10.5 0.5 0.44 9.9 0.5 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase DUF3228 PF11539.8 EFC48182.1 - 1.1e-87 292.6 0.2 1.2e-87 292.4 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) HTH_WhiA PF02650.14 EFC48183.1 - 0.048 14.0 2.3 0.23 11.8 2.3 2.2 1 0 0 1 1 1 0 WhiA C-terminal HTH domain DUF4776 PF16003.5 EFC48183.1 - 0.38 9.7 4.5 0.17 10.9 2.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4776) Syntaxin_2 PF14523.6 EFC48183.1 - 6.7 7.1 11.3 0.27 11.6 2.9 2.8 1 1 2 3 3 3 0 Syntaxin-like protein RF-1 PF00472.20 EFC48185.1 - 3.5e-21 75.3 0.3 3.9e-21 75.1 0.3 1.1 1 0 0 1 1 1 1 RF-1 domain POC3_POC4 PF10448.9 EFC48185.1 - 0.038 14.0 0.0 0.049 13.6 0.0 1.2 1 0 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 PSDC PF12588.8 EFC48186.1 - 0.0038 17.2 0.4 0.007 16.3 0.4 1.4 1 0 0 1 1 1 1 Phophatidylserine decarboxylase Mod_r PF07200.13 EFC48186.1 - 1.7 8.8 9.4 0.98 9.5 5.3 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Brix PF04427.18 EFC48187.1 - 3.2e-40 138.3 3.4 6e-40 137.4 3.4 1.5 1 0 0 1 1 1 1 Brix domain RNA_pol_Rpb4 PF03874.16 EFC48188.1 - 3.6e-17 62.8 2.8 3.6e-17 62.8 2.8 3.1 3 0 0 3 3 3 1 RNA polymerase Rpb4 zf-CCHC PF00098.23 EFC48188.1 - 0.0011 19.0 27.3 0.026 14.6 2.8 4.9 5 0 0 5 5 5 3 Zinc knuckle zf-CCHC_2 PF13696.6 EFC48188.1 - 0.031 14.1 17.9 0.82 9.6 0.1 4.6 4 0 0 4 4 4 0 Zinc knuckle zf-C2H2_10 PF16588.5 EFC48188.1 - 0.18 11.5 12.3 0.25 11.1 0.2 3.7 3 0 0 3 3 3 0 C2H2 zinc-finger zf-CCHC_3 PF13917.6 EFC48188.1 - 4 7.5 16.9 9 6.4 0.5 4.6 4 0 0 4 4 4 0 Zinc knuckle LRR_6 PF13516.6 EFC48189.1 - 5.1e-36 119.6 33.7 0.0009 19.1 0.1 13.8 15 0 0 15 15 15 11 Leucine Rich repeat LRR_4 PF12799.7 EFC48189.1 - 4.4e-19 68.3 50.5 0.00075 19.8 0.8 11.2 5 4 8 14 14 14 11 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48189.1 - 2.7e-09 36.3 20.9 1.8 9.4 0.1 11.6 13 1 0 13 13 13 3 Leucine Rich Repeat LRR_8 PF13855.6 EFC48189.1 - 1.4e-08 34.4 34.3 0.1 12.4 2.6 9.5 4 3 5 9 9 9 7 Leucine rich repeat LRR_9 PF14580.6 EFC48189.1 - 6.2e-06 25.8 7.1 0.44 10.0 0.1 5.3 1 1 3 5 5 5 3 Leucine-rich repeat F-box-like PF12937.7 EFC48189.1 - 1.9e-05 24.4 0.2 4.9e-05 23.1 0.2 1.7 1 0 0 1 1 1 1 F-box-like LRR_2 PF07723.13 EFC48189.1 - 0.025 15.3 1.3 10 7.0 0.0 5.1 6 0 0 6 6 6 0 Leucine Rich Repeat RrnaAD PF00398.20 EFC48190.1 - 2e-63 213.9 0.4 2.5e-63 213.6 0.4 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 EFC48190.1 - 1.2e-08 35.5 0.0 2.8e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC48190.1 - 6.6e-06 26.7 0.0 2e-05 25.1 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Met_10 PF02475.16 EFC48190.1 - 7.2e-05 22.6 0.2 0.00024 20.9 0.0 1.8 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_4 PF02390.17 EFC48190.1 - 0.00011 21.7 0.2 0.0009 18.8 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase PCMT PF01135.19 EFC48190.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 EFC48190.1 - 0.00017 22.3 0.0 0.00039 21.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 EFC48190.1 - 0.00048 20.0 0.6 0.0036 17.2 0.0 2.1 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase Methyltransf_31 PF13847.6 EFC48190.1 - 0.001 18.9 0.0 0.0018 18.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC48190.1 - 0.0011 18.4 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 EFC48190.1 - 0.0012 18.5 0.1 0.0024 17.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 EFC48190.1 - 0.0012 18.5 0.2 0.019 14.6 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical protein 95 CMAS PF02353.20 EFC48190.1 - 0.0016 17.8 0.3 0.003 16.9 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 EFC48190.1 - 0.0018 18.2 0.6 0.0039 17.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC48190.1 - 0.0025 17.7 0.0 0.0039 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 EFC48190.1 - 0.0047 16.6 0.1 0.01 15.5 0.0 1.5 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 DREV PF05219.12 EFC48190.1 - 0.0089 15.2 0.1 0.027 13.6 0.0 1.8 2 0 0 2 2 2 1 DREV methyltransferase NodS PF05401.11 EFC48190.1 - 0.01 15.4 0.2 0.034 13.8 0.0 1.8 2 0 0 2 2 2 0 Nodulation protein S (NodS) PrmA PF06325.13 EFC48190.1 - 0.022 14.2 0.1 0.051 12.9 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 EFC48190.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_28 PF02636.17 EFC48190.1 - 0.13 11.9 0.5 0.37 10.4 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase WD40 PF00400.32 EFC48191.1 - 5.2e-29 99.9 24.2 0.00032 21.4 0.2 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48191.1 - 4.7e-06 26.8 3.7 1.2 9.4 0.2 4.8 3 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Rhomboid PF01694.22 EFC48193.1 - 2e-21 76.5 7.1 3.5e-21 75.8 7.1 1.3 1 0 0 1 1 1 1 Rhomboid family Polysacc_synt_C PF14667.6 EFC48193.1 - 0.0078 16.3 0.9 0.0078 16.3 0.9 2.2 3 0 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain DSPc PF00782.20 EFC48194.1 - 7.3e-35 119.7 0.1 8.2e-35 119.5 0.1 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 EFC48194.1 - 0.0016 18.7 0.1 0.003 17.8 0.1 1.6 1 1 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 EFC48194.1 - 0.0047 16.5 0.0 0.0054 16.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFC48194.1 - 0.07 13.2 0.0 0.09 12.9 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Rhodanese PF00581.20 EFC48194.1 - 0.098 13.2 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Rhodanese-like domain GcpE PF04551.14 EFC48194.1 - 0.11 11.6 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 GcpE protein PspB PF06667.12 EFC48196.1 - 0.076 13.1 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Phage shock protein B Ras PF00071.22 EFC48197.1 - 0.00013 21.6 0.9 0.00022 20.9 0.9 1.3 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC48197.1 - 0.00014 21.3 0.2 0.00018 21.0 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC48197.1 - 0.0012 18.4 0.1 0.0017 18.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC48197.1 - 0.029 13.7 2.5 0.037 13.4 2.5 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 EFC48197.1 - 0.033 14.2 1.9 0.15 12.1 0.3 2.5 1 1 2 3 3 3 0 C-terminal region of MMR_HSR1 domain ARL2_Bind_BART PF11527.8 EFC48197.1 - 0.039 14.1 4.5 3.1 7.9 0.3 2.3 2 0 0 2 2 2 0 The ARF-like 2 binding protein BART EVI2A PF05399.11 EFC48198.1 - 1.2e-06 28.3 6.3 2e-06 27.6 6.3 1.3 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) LAP1C PF05609.12 EFC48198.1 - 0.0029 16.8 6.7 0.004 16.3 6.7 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Glypican PF01153.19 EFC48198.1 - 0.019 13.8 5.0 0.023 13.5 5.0 1.1 1 0 0 1 1 1 0 Glypican Cortexin PF11057.8 EFC48198.1 - 0.024 14.5 0.4 0.024 14.5 0.4 3.0 2 1 1 3 3 3 0 Cortexin of kidney Zip PF02535.22 EFC48198.1 - 0.043 13.0 13.4 0.16 11.2 13.1 1.8 1 1 0 1 1 1 0 ZIP Zinc transporter DUF1563 PF07599.11 EFC48198.1 - 0.093 12.8 1.6 9.9 6.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1563) Macoilin PF09726.9 EFC48198.1 - 0.11 11.1 8.6 0.13 10.8 8.6 1.1 1 0 0 1 1 1 0 Macoilin family Anoctamin PF04547.12 EFC48198.1 - 0.11 11.3 7.1 2.2 7.0 4.2 2.7 2 1 0 2 2 2 0 Calcium-activated chloride channel TMEM154 PF15102.6 EFC48198.1 - 0.36 10.7 6.8 0.17 11.8 1.6 2.6 1 1 2 3 3 3 0 TMEM154 protein family DUF1180 PF06679.12 EFC48198.1 - 0.92 9.9 6.6 0.55 10.6 3.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1180) MAP17 PF15807.5 EFC48198.1 - 0.95 9.7 8.7 5.9 7.1 0.1 2.5 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TPR_2 PF07719.17 EFC48199.1 - 1.1e-22 78.2 8.3 0.0005 20.0 0.1 8.4 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48199.1 - 7.5e-18 64.6 5.1 4.2e-08 33.3 0.2 5.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48199.1 - 8.7e-18 63.0 16.2 7e-05 22.7 0.2 8.3 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48199.1 - 4.7e-16 57.9 7.5 0.0077 16.5 0.0 8.7 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48199.1 - 9.3e-15 53.7 17.5 0.00054 19.7 0.2 7.7 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48199.1 - 1.4e-13 50.4 0.2 0.0039 17.9 0.0 7.4 5 2 4 9 9 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48199.1 - 4.8e-12 46.2 8.4 1.3e-05 25.6 0.1 6.2 6 2 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48199.1 - 8e-12 44.6 3.4 1.8e-07 30.7 0.0 5.3 5 1 1 6 6 6 1 TPR repeat TPR_7 PF13176.6 EFC48199.1 - 1.7e-11 43.3 1.7 0.014 15.4 0.2 5.8 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48199.1 - 3.1e-08 34.1 0.0 0.00044 20.8 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC48199.1 - 1.4e-07 31.1 4.0 0.17 11.8 0.2 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC48199.1 - 1.1e-06 28.8 9.1 0.65 10.8 0.1 6.6 6 0 0 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC48199.1 - 6e-06 26.4 6.7 5.8e-05 23.2 1.2 4.2 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 EFC48199.1 - 0.00066 19.8 0.0 2.3 8.4 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC48199.1 - 0.00091 18.7 0.0 0.066 12.6 0.0 2.4 1 1 0 1 1 1 1 MalT-like TPR region TPR_15 PF13429.6 EFC48199.1 - 0.0031 16.8 1.5 0.14 11.3 0.2 2.9 1 1 0 2 2 2 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFC48199.1 - 0.14 12.1 0.1 0.14 12.1 0.1 3.7 4 0 0 4 4 4 0 Mad3/BUB1 homology region 1 MIT PF04212.18 EFC48199.1 - 4.4 7.4 8.3 1.2 9.2 0.2 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain PEMT PF04191.13 EFC48200.1 - 3.2e-32 111.1 2.6 5.7e-32 110.3 2.6 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase UCH PF00443.29 EFC48201.1 - 6.4e-75 252.0 2.3 1.3e-74 251.0 2.3 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFC48201.1 - 6.2e-18 65.2 0.5 6.2e-17 62.0 0.0 2.9 3 0 0 3 3 3 1 DUSP domain UCH_1 PF13423.6 EFC48201.1 - 5.5e-11 42.6 3.8 6.4e-05 22.7 1.0 3.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 EFC48201.1 - 1.3e-07 31.5 0.3 0.00014 21.6 0.0 2.6 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal TUG-UBL1 PF11470.8 EFC48201.1 - 0.039 14.2 0.1 10 6.4 0.0 2.9 2 0 0 2 2 2 0 TUG ubiquitin-like domain zf-ribbon_3 PF13248.6 EFC48201.1 - 0.089 12.2 0.8 12 5.4 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain ubiquitin PF00240.23 EFC48201.1 - 1.2 9.0 3.4 11 5.8 0.0 4.1 5 0 0 5 5 5 0 Ubiquitin family zf-MIZ PF02891.20 EFC48201.1 - 1.2 9.0 3.1 0.55 10.0 0.2 1.9 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger GDP_Man_Dehyd PF16363.5 EFC48202.1 - 1.4e-155 517.7 0.0 1.6e-155 517.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 EFC48202.1 - 1.3e-72 244.2 0.0 1.6e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 EFC48202.1 - 6.2e-06 25.5 0.0 8.9e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 EFC48202.1 - 0.00037 19.7 0.0 0.00053 19.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFC48202.1 - 0.04 13.1 0.0 0.087 12.0 0.0 1.5 1 1 0 1 1 1 0 Male sterility protein adh_short PF00106.25 EFC48202.1 - 0.073 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NmrA PF05368.13 EFC48202.1 - 0.11 12.1 0.1 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family NAD_binding_10 PF13460.6 EFC48202.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding Metallophos PF00149.28 EFC48203.1 - 1.5e-12 48.5 2.5 2.4e-12 47.8 2.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC48203.1 - 5e-07 30.1 0.1 3.8e-05 23.9 0.0 2.5 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain ketoacyl-synt PF00109.26 EFC48204.1 - 3e-77 259.6 0.0 2.2e-76 256.8 0.0 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 EFC48204.1 - 2e-51 175.4 0.0 4.7e-51 174.2 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 EFC48204.1 - 6.3e-49 166.3 1.6 1e-47 162.3 0.1 2.6 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 EFC48204.1 - 6.1e-37 127.5 0.0 1e-36 126.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Chal_sti_synt_N PF00195.19 EFC48204.1 - 1.8e-32 112.6 0.0 3.3e-32 111.7 0.0 1.4 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain Ketoacyl-synt_C PF02801.22 EFC48204.1 - 2.4e-30 105.0 0.0 8.8e-30 103.1 0.0 2.1 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Chal_sti_synt_C PF02797.15 EFC48204.1 - 1.1e-23 83.9 0.0 3.4e-23 82.3 0.0 1.9 1 0 0 1 1 1 1 Chalcone and stilbene synthases, C-terminal domain KAsynt_C_assoc PF16197.5 EFC48204.1 - 2.3e-17 63.5 0.0 6.5e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 EFC48204.1 - 3.4e-15 57.3 0.0 3.9e-14 53.8 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC48204.1 - 6.9e-13 48.7 0.1 4.8e-12 46.0 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PP-binding PF00550.25 EFC48204.1 - 4.6e-09 36.5 0.0 1.6e-08 34.8 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site FAE1_CUT1_RppA PF08392.12 EFC48204.1 - 1.6e-08 34.2 0.0 4e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein adh_short PF00106.25 EFC48204.1 - 8.4e-08 31.9 0.2 8.4e-08 31.9 0.2 2.6 2 0 0 2 2 2 1 short chain dehydrogenase ACP_syn_III_C PF08541.10 EFC48204.1 - 6.6e-07 29.4 0.0 5.5e-06 26.5 0.0 2.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ADH_N PF08240.12 EFC48204.1 - 1.6e-06 28.0 0.0 4.6e-06 26.5 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.6 EFC48204.1 - 5.5e-06 26.1 0.1 5.5e-06 26.1 0.1 2.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ACP_syn_III PF08545.10 EFC48204.1 - 3.3e-05 23.7 1.9 0.00031 20.5 0.0 3.1 3 0 0 3 3 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 EFC48204.1 - 9.1e-05 21.9 0.4 0.00043 19.7 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Polysacc_synt_2 PF02719.15 EFC48204.1 - 0.0009 18.5 0.3 0.0009 18.5 0.3 1.8 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein LEM PF03020.15 EFC48204.1 - 0.097 12.2 0.0 0.32 10.6 0.0 1.9 1 0 0 1 1 1 0 LEM domain Thg1C PF14413.6 EFC48204.1 - 0.7 10.1 3.8 6.1 7.0 0.2 2.6 2 0 0 2 2 2 0 Thg1 C terminal domain Sulf_transp PF04143.14 EFC48205.1 - 1.5e-39 136.4 36.5 2.2e-28 99.7 14.0 2.8 3 0 0 3 3 3 2 Sulphur transport ATP19 PF11022.8 EFC48205.1 - 0.069 13.5 1.4 36 4.8 0.2 3.9 3 1 0 3 3 3 0 ATP synthase subunit K SieB PF14163.6 EFC48205.1 - 0.085 12.3 1.2 0.47 9.9 0.2 2.5 2 0 0 2 2 2 0 Super-infection exclusion protein B PAP_PilO PF06864.12 EFC48205.1 - 0.18 10.6 0.0 0.92 8.3 0.0 1.9 2 0 0 2 2 2 0 Pilin accessory protein (PilO) RCC1 PF00415.18 EFC48206.1 - 1.8e-23 82.9 0.0 4e-07 30.6 0.0 5.2 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC48206.1 - 1.3e-13 50.3 2.7 0.0015 18.2 0.0 5.6 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 EFC48206.1 - 0.0001 22.5 3.0 0.0001 22.5 3.0 3.0 4 1 0 4 4 4 1 BTB/POZ domain Cys_rich_VLP PF14194.6 EFC48206.1 - 0.055 13.6 0.6 0.2 11.8 0.6 1.9 1 0 0 1 1 1 0 Cysteine-rich VLP La_HTH_kDCL PF18177.1 EFC48206.1 - 0.1 12.9 0.5 0.29 11.4 0.1 2.0 2 0 0 2 2 2 0 La HTH in kinetoplastid DICER domain TMEM18 PF14770.6 EFC48208.1 - 1.1e-38 131.8 10.0 1.6e-38 131.3 10.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 18 MAP17 PF15807.5 EFC48208.1 - 0.018 15.2 1.2 0.43 10.8 0.1 2.4 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 YniB PF14002.6 EFC48208.1 - 0.019 14.7 3.8 0.029 14.1 3.8 1.2 1 0 0 1 1 1 0 YniB-like protein RseC_MucC PF04246.12 EFC48208.1 - 0.27 11.2 2.8 0.62 10.0 0.6 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC PTPLA PF04387.14 EFC48211.1 - 3.3e-60 202.6 15.9 5.1e-60 201.9 15.9 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Rap1_C PF11626.8 EFC48212.1 - 9.2e-08 32.1 0.9 1.9e-07 31.1 0.0 2.0 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.31 EFC48212.1 - 0.16 12.2 0.4 8.8 6.6 0.0 2.7 3 0 0 3 3 3 0 Myb-like DNA-binding domain Zn_Tnp_IS91 PF14319.6 EFC48214.1 - 0.0032 17.5 5.9 0.0032 17.5 5.9 3.0 2 0 0 2 2 2 1 Transposase zinc-binding domain zf-B_box PF00643.24 EFC48214.1 - 0.011 15.8 4.6 0.011 15.8 4.6 3.0 3 2 0 3 3 3 0 B-box zinc finger Nop14 PF04147.12 EFC48214.1 - 0.28 9.3 15.8 0.52 8.5 15.8 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 EFC48214.1 - 5.8 5.1 14.5 9.1 4.4 14.5 1.2 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 EFC48215.1 - 1.2e-10 41.7 10.4 0.00038 21.2 0.8 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48215.1 - 5.4e-07 29.8 0.1 0.2 12.0 0.1 4.8 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Abhydro_lipase PF04083.16 EFC48216.1 - 9.4e-20 70.0 0.0 1.7e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 EFC48216.1 - 9.9e-17 61.4 0.0 3.3e-16 59.7 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC48216.1 - 1.2e-05 24.7 0.0 0.00092 18.5 0.0 2.3 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 EFC48216.1 - 0.084 11.8 0.0 0.26 10.2 0.0 1.8 3 0 0 3 3 3 0 Chlorophyllase enzyme Phos_pyr_kin PF08543.12 EFC48217.1 - 1.2e-86 290.1 0.2 1.6e-86 289.7 0.2 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 EFC48217.1 - 3.8e-26 92.2 3.3 5.8e-26 91.6 3.3 1.2 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 EFC48217.1 - 2.8e-08 33.4 0.1 7.8e-08 32.0 0.1 1.7 1 0 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 EFC48217.1 - 0.011 15.1 0.1 0.018 14.4 0.1 1.4 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family Amidase_3 PF01520.18 EFC48217.1 - 0.024 14.8 0.1 0.1 12.7 0.1 1.9 2 0 0 2 2 2 0 N-acetylmuramoyl-L-alanine amidase DUF4854 PF16146.5 EFC48218.1 - 1 9.8 5.1 3.8 7.9 0.9 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4854) RNA_pol_Rpb4 PF03874.16 EFC48219.1 - 6.6e-11 42.6 0.3 1.3e-10 41.6 0.3 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 Njmu-R1 PF15053.6 EFC48219.1 - 0.057 12.5 0.0 0.059 12.5 0.0 1.1 1 0 0 1 1 1 0 Mjmu-R1-like protein family HU-DNA_bdg PF14848.6 EFC48219.1 - 0.1 12.6 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 DNA-binding domain Orthopox_35kD PF02250.15 EFC48219.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 35kD major secreted virus protein NUC153 PF08159.12 EFC48220.1 - 0.17 11.8 2.3 3.5 7.5 1.9 2.7 2 0 0 2 2 2 0 NUC153 domain CENP-B_dimeris PF09026.10 EFC48220.1 - 0.3 11.5 7.7 1.1 9.6 7.7 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cauli_AT PF03233.13 EFC48220.1 - 0.47 10.4 6.1 0.11 12.5 2.0 2.0 2 0 0 2 2 2 0 Aphid transmission protein FAM176 PF14851.6 EFC48220.1 - 5.3 6.7 7.1 9.3 5.9 5.4 2.3 2 0 0 2 2 2 0 FAM176 family Helicase_C PF00271.31 EFC48221.1 - 1.8e-11 44.3 0.1 8.4e-11 42.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SUV3_C PF12513.8 EFC48221.1 - 1.4e-10 41.0 1.3 1.4e-10 41.0 1.3 2.3 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Complex1_LYR_2 PF13233.6 EFC48223.1 - 0.00014 22.5 0.2 0.00015 22.4 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 EFC48223.1 - 0.062 13.3 0.5 0.12 12.4 0.5 1.7 1 1 0 1 1 1 0 Complex 1 protein (LYR family) Lysine_decarbox PF03641.14 EFC48224.1 - 6.5e-31 107.2 0.1 7.8e-31 106.9 0.1 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 EFC48224.1 - 4.1e-16 59.0 0.0 4.1e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 SLOG cluster4 family ORC6 PF05460.13 EFC48225.1 - 0.012 14.9 1.5 0.013 14.8 1.5 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) GET2 PF08690.10 EFC48225.1 - 0.014 15.1 0.1 0.016 14.9 0.1 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 DUF2207 PF09972.9 EFC48225.1 - 0.025 13.4 0.1 0.027 13.2 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ASL_C2 PF14698.6 EFC48225.1 - 0.076 13.8 0.0 0.12 13.1 0.0 1.3 1 0 0 1 1 1 0 Argininosuccinate lyase C-terminal DUF543 PF04418.12 EFC48225.1 - 0.12 12.4 1.0 0.27 11.2 1.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF543) YjeJ PF15922.5 EFC48225.1 - 0.18 11.0 1.3 0.2 10.9 0.3 1.5 1 1 0 2 2 2 0 YjeJ-like DUF1615 PF07759.12 EFC48225.1 - 0.24 10.6 1.6 0.26 10.4 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1615) Myc_target_1 PF15179.6 EFC48225.1 - 0.83 9.5 5.4 0.78 9.6 0.2 2.1 1 1 1 2 2 2 0 Myc target protein 1 Erg28 PF03694.13 EFC48226.1 - 6.7e-21 74.8 1.7 8.1e-21 74.5 1.7 1.1 1 0 0 1 1 1 1 Erg28 like protein AMP-binding PF00501.28 EFC48227.1 - 1.3e-72 244.7 0.0 3.4e-72 243.4 0.0 1.7 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC48227.1 - 2.7e-12 47.5 0.0 4.9e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain V-ATPase_H_N PF03224.14 EFC48228.1 - 4e-51 174.2 12.4 9.1e-51 173.0 11.3 2.0 2 1 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 EFC48228.1 - 2.1e-43 147.2 7.0 2.1e-42 143.9 0.3 3.3 2 1 0 3 3 3 2 V-ATPase subunit H Arm PF00514.23 EFC48228.1 - 0.0097 15.9 6.0 2.5 8.3 0.1 4.5 4 1 1 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 EFC48228.1 - 0.014 15.6 0.1 0.7 10.3 0.0 3.5 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 EFC48228.1 - 0.035 14.6 0.0 19 5.9 0.0 4.1 4 0 0 4 4 4 0 HEAT-like repeat SPRY PF00622.28 EFC48230.1 - 4.1e-05 23.7 0.1 7.3e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Orthopox_B11R PF07033.11 EFC48230.1 - 0.037 13.8 0.4 0.037 13.8 0.4 2.7 2 1 1 3 3 3 0 Orthopoxvirus B11R protein Med23 PF11573.8 EFC48231.1 - 2.1e-42 145.0 13.0 2.1e-42 145.0 13.0 1.9 2 0 0 2 2 2 1 Mediator complex subunit 23 Aldedh PF00171.22 EFC48232.1 - 2.9e-125 418.4 0.1 3.5e-125 418.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family TPR_1 PF00515.28 EFC48233.1 - 8e-07 28.6 0.1 0.0067 16.2 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48233.1 - 9e-07 28.6 0.3 1 9.8 0.0 6.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48233.1 - 5.7e-06 26.3 0.1 17 6.0 0.0 5.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48233.1 - 1.9e-05 24.4 0.0 0.009 16.1 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48233.1 - 0.00079 19.7 0.0 0.45 10.8 0.0 4.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48233.1 - 0.0088 15.7 0.0 5.1 6.9 0.1 2.8 2 0 0 2 2 2 2 TPR repeat TPR_19 PF14559.6 EFC48233.1 - 0.047 14.2 0.0 20 5.8 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48233.1 - 0.081 13.8 0.0 0.6 11.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Qua1 PF16274.5 EFC48233.1 - 0.12 12.2 0.2 17 5.3 0.1 3.1 3 0 0 3 3 3 0 Qua1 domain QRPTase_C PF01729.19 EFC48233.1 - 0.14 11.9 0.0 1.1 9.0 0.0 2.0 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain MtN3_slv PF03083.16 EFC48234.1 - 5.2e-26 90.5 18.7 1.7e-17 63.3 2.6 2.7 2 1 0 3 3 3 2 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 EFC48234.1 - 0.04 14.0 11.2 0.44 10.6 1.2 3.5 2 2 2 4 4 4 0 Lipid A Biosynthesis N-terminal domain Rer1 PF03248.13 EFC48234.1 - 0.62 9.8 4.4 0.27 11.0 0.6 1.9 1 1 1 2 2 2 0 Rer1 family DUF1129 PF06570.11 EFC48234.1 - 0.96 8.9 4.9 1.1 8.7 0.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) RseC_MucC PF04246.12 EFC48234.1 - 6.3 6.8 7.8 2.8 7.9 0.1 2.6 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC zf-RING_2 PF13639.6 EFC48235.1 - 3.8e-10 39.9 14.6 3.8e-10 39.9 14.6 2.6 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 EFC48235.1 - 2.2e-06 27.9 13.0 5.1e-06 26.7 13.0 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 EFC48235.1 - 1.6e-05 24.7 12.1 1.6e-05 24.7 12.1 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 EFC48235.1 - 5.1e-05 22.9 7.1 5.1e-05 22.9 7.1 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFC48235.1 - 0.00019 21.2 13.2 0.00044 20.0 13.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC48235.1 - 0.00023 21.0 14.5 0.00077 19.3 14.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFC48235.1 - 0.00051 20.0 7.6 0.0011 19.0 7.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 EFC48235.1 - 0.0071 16.2 11.4 0.015 15.1 11.4 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 EFC48235.1 - 0.14 12.0 6.3 0.32 10.8 6.3 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 EFC48235.1 - 6.3 6.9 16.9 0.04 13.9 5.6 2.8 3 0 0 3 3 3 0 RING-type zinc-finger MFAP1 PF06991.11 EFC48236.1 - 9.5e-44 149.8 22.8 9.5e-44 149.8 22.8 3.0 1 1 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing Epimerase PF01370.21 EFC48237.1 - 5e-46 157.1 0.0 6.2e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC48237.1 - 5.3e-44 151.0 0.0 7.8e-44 150.4 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC48237.1 - 2.6e-24 85.7 0.0 4e-24 85.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 EFC48237.1 - 5.4e-16 58.6 0.1 1.8e-15 56.8 0.1 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFC48237.1 - 1.8e-10 40.4 0.0 2.7e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 EFC48237.1 - 1.3e-06 27.8 0.0 4.2e-06 26.1 0.0 1.7 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 EFC48237.1 - 0.0058 16.6 0.0 0.016 15.2 0.0 1.6 2 0 0 2 2 2 1 KR domain Ldh_1_N PF00056.23 EFC48237.1 - 0.045 13.9 0.0 0.077 13.1 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain SNAD2 PF18745.1 EFC48238.1 - 0.098 12.4 3.3 0.18 11.5 1.4 2.0 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 2 DUF563 PF04577.14 EFC48239.1 - 3.2e-27 96.0 0.1 5.5e-27 95.3 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) VIT PF08487.10 EFC48241.1 - 1.4e-13 51.0 0.0 3.5e-13 49.7 0.0 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2135 PF09906.9 EFC48241.1 - 0.0018 18.6 1.3 0.0062 16.8 1.3 2.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2135) TPR_8 PF13181.6 EFC48241.1 - 0.03 14.5 1.0 0.16 12.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48241.1 - 0.048 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48241.1 - 0.056 13.6 0.1 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4419 PF14388.6 EFC48242.1 - 1.5e-101 339.9 0.1 1.8e-101 339.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) RGS PF00615.19 EFC48243.1 - 3.4e-12 46.7 0.6 6.8e-12 45.7 0.6 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain LAGLIDADG_2 PF03161.13 EFC48243.1 - 0.015 15.3 0.2 5.6 7.0 0.1 2.5 2 0 0 2 2 2 0 LAGLIDADG DNA endonuclease family DUF5134 PF17197.4 EFC48243.1 - 0.11 12.4 1.2 11 5.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5134) RGS PF00615.19 EFC48244.1 - 2.8e-11 43.7 0.3 6.4e-11 42.6 0.3 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Vma12 PF11712.8 EFC48244.1 - 2.3 8.3 8.8 3.9 7.5 1.7 3.3 2 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4116 PF13475.6 EFC48245.1 - 8.9e-54 179.0 69.5 6.2e-11 41.8 0.3 12.9 8 3 9 17 17 17 15 Domain of unknown function (DUF4116) RNase_T PF00929.24 EFC48246.1 - 6.7e-10 39.8 0.2 7.8e-10 39.5 0.2 1.1 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 EFC48246.1 - 0.0034 17.4 0.0 0.0046 17.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like RNase_H_2 PF13482.6 EFC48246.1 - 0.045 13.8 0.3 0.059 13.3 0.3 1.3 1 1 0 1 1 1 0 RNase_H superfamily LCAT PF02450.15 EFC48248.1 - 2.8e-42 145.3 5.3 1e-31 110.5 0.1 2.1 1 1 1 2 2 2 2 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 EFC48248.1 - 0.00011 21.8 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF900 PF05990.12 EFC48248.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF915 PF06028.11 EFC48248.1 - 0.067 12.5 5.0 0.41 9.9 0.2 2.6 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) F-box-like PF12937.7 EFC48249.1 - 2.7e-10 39.9 0.1 5.1e-10 39.1 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48249.1 - 2e-06 27.5 0.2 8.7e-06 25.5 0.0 2.1 2 0 0 2 2 2 1 F-box domain DUF713 PF05218.14 EFC48249.1 - 0.045 13.5 0.1 0.095 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF713) DUF202 PF02656.15 EFC48249.1 - 0.77 10.3 2.7 1.5 9.4 0.2 2.6 3 1 0 3 3 3 0 Domain of unknown function (DUF202) F-box-like PF12937.7 EFC48250.1 - 0.0004 20.2 0.0 0.00064 19.6 0.0 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48250.1 - 0.00061 19.6 0.1 0.0016 18.3 0.1 1.8 1 1 0 1 1 1 1 F-box domain RisS_PPD PF16524.5 EFC48250.1 - 0.026 14.8 0.4 0.16 12.2 0.0 2.2 2 1 1 3 3 3 0 Periplasmic domain of Sensor histidine kinase RisS Poxvirus_B22R_N PF13169.6 EFC48250.1 - 0.51 10.9 9.2 0.28 11.7 3.9 2.5 1 1 1 2 2 2 0 Poxvirus B22R protein N-terminal DUF4342 PF14242.6 EFC48250.1 - 0.69 9.9 2.8 1.5 8.9 2.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4342) Carbpep_Y_N PF05388.11 EFC48250.1 - 3 8.4 9.4 0.27 11.8 2.0 2.0 1 1 1 2 2 2 0 Carboxypeptidase Y pro-peptide KH_1 PF00013.29 EFC48251.1 - 7.1e-12 45.0 2.6 2e-11 43.6 2.6 1.8 1 0 0 1 1 1 1 KH domain RNA_pol_Rpb1_5 PF04998.17 EFC48251.1 - 1.2 8.5 3.8 2.6 7.4 3.8 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 ATP-synt_8 PF00895.20 EFC48252.1 - 0.015 15.7 0.7 10 6.7 0.2 2.9 2 0 0 2 2 2 0 ATP synthase protein 8 DUF2405 PF10293.9 EFC48252.1 - 0.037 14.0 0.0 0.054 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2405) DUF2970 PF11174.8 EFC48252.1 - 0.11 12.4 0.1 0.11 12.4 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2970) PEX11 PF05648.14 EFC48252.1 - 0.14 11.6 0.0 0.29 10.5 0.0 1.5 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) DUF2681 PF10883.8 EFC48252.1 - 0.15 12.5 0.1 0.32 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) OAD_gamma PF04277.13 EFC48252.1 - 0.16 12.6 0.2 0.16 12.6 0.2 2.9 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain GRP PF07172.11 EFC48252.1 - 0.2 12.4 0.3 0.97 10.2 0.1 2.0 2 0 0 2 2 2 0 Glycine rich protein family Pkinase PF00069.25 EFC48253.1 - 1.9e-46 158.6 1.4 1.9e-46 158.6 1.4 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48253.1 - 1.9e-28 99.5 1.2 2.7e-28 99.0 0.3 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase DUF2263 PF10021.9 EFC48253.1 - 1.4e-14 54.7 0.0 4.6e-14 53.0 0.0 2.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) WD40 PF00400.32 EFC48253.1 - 6.1e-09 36.4 0.8 0.2 12.6 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Kinase-like PF14531.6 EFC48253.1 - 0.018 14.3 1.1 0.75 9.1 1.1 3.0 1 1 0 1 1 1 0 Kinase-like Peptidase_C2 PF00648.21 EFC48254.1 - 5.7e-41 140.5 0.0 1e-40 139.6 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease VHL PF01847.16 EFC48254.1 - 4.4e-14 52.1 0.0 9.1e-07 28.7 0.0 2.5 2 0 0 2 2 2 2 VHL beta domain Eaf7 PF07904.13 EFC48255.1 - 8.7e-10 38.9 0.1 2.6e-09 37.4 0.1 2.0 1 1 0 1 1 1 1 Chromatin modification-related protein EAF7 NOA36 PF06524.12 EFC48256.1 - 2.6 7.3 6.1 3.1 7.0 6.1 1.1 1 0 0 1 1 1 0 NOA36 protein Peptidase_C2 PF00648.21 EFC48258.1 - 1.1e-65 221.7 0.0 2.3e-65 220.6 0.0 1.6 1 0 0 1 1 1 1 Calpain family cysteine protease TPR_2 PF07719.17 EFC48258.1 - 2e-14 52.4 12.0 0.00014 21.7 0.0 8.8 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48258.1 - 4e-13 48.6 20.8 0.00027 20.6 0.0 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48258.1 - 1.7e-11 43.6 4.1 0.0056 17.0 0.0 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48258.1 - 8.8e-10 38.0 20.0 0.00047 20.2 0.0 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48258.1 - 6.8e-09 35.9 2.4 0.36 11.2 0.0 5.9 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48258.1 - 2.1e-06 27.3 6.9 0.00016 21.3 0.1 4.4 5 0 0 5 5 5 1 TPR repeat TPR_14 PF13428.6 EFC48258.1 - 8e-05 23.2 0.0 2.3 9.2 0.0 5.0 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48258.1 - 0.00045 20.8 0.0 0.94 10.2 0.0 4.8 6 0 0 6 6 5 1 Tetratricopeptide repeat Calpain_III PF01067.22 EFC48258.1 - 0.00062 20.1 1.2 0.0012 19.1 0.1 2.1 2 0 0 2 2 2 1 Calpain large subunit, domain III TPR_6 PF13174.6 EFC48258.1 - 0.0017 18.9 5.6 7.3 7.5 0.0 6.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 EFC48258.1 - 0.0052 16.9 0.0 0.99 9.6 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48258.1 - 0.0096 15.9 0.1 38 4.6 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC48258.1 - 0.081 13.0 0.6 9.3 6.4 0.0 3.9 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EFC48258.1 - 0.11 12.7 4.1 13 6.1 0.0 4.3 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC48258.1 - 0.5 10.9 9.4 7.7 7.1 0.1 5.0 5 1 1 6 6 4 0 Tetratricopeptide repeat LRR_8 PF13855.6 EFC48259.1 - 3.7e-25 87.5 22.6 9.3e-07 28.5 0.0 8.8 7 1 1 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC48259.1 - 3.9e-21 74.8 48.0 0.0021 18.5 0.1 10.6 3 2 7 11 11 11 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC48259.1 - 2.2e-17 61.6 29.5 0.029 14.4 0.0 12.8 13 0 0 13 13 13 7 Leucine Rich repeat F-box-like PF12937.7 EFC48259.1 - 0.0019 18.1 0.3 0.0058 16.5 0.3 1.9 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC48259.1 - 1.9 9.3 34.2 28 5.8 0.0 12.1 14 1 0 14 14 14 0 Leucine Rich Repeat Methyltransf_24 PF13578.6 EFC48261.1 - 0.00025 22.0 0.0 0.00044 21.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain LRR_6 PF13516.6 EFC48262.1 - 3.1e-41 135.9 6.2 1e-05 25.2 0.0 9.0 9 0 0 9 9 9 8 Leucine Rich repeat LRR_8 PF13855.6 EFC48262.1 - 1.8e-32 110.9 18.5 1.7e-08 34.1 0.7 4.2 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC48262.1 - 3.1e-28 97.3 18.9 1.4e-05 25.3 0.2 5.5 1 1 7 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48262.1 - 6.3e-16 56.5 0.0 2 9.3 0.0 8.9 9 0 0 9 9 9 1 Leucine Rich Repeat Spidroin_N PF16763.5 EFC48262.1 - 0.00023 21.2 2.6 74 3.4 0.0 6.4 2 1 5 7 7 7 0 Major ampullate spidroin 1, spider silk protein 1, N-term DUF5490 PF17593.2 EFC48262.1 - 0.00046 20.1 1.0 66 3.6 0.0 6.2 3 2 4 7 7 7 0 Family of unknown function (DUF5490) LRR_9 PF14580.6 EFC48262.1 - 0.0022 17.5 0.0 0.11 12.0 0.0 2.3 1 1 1 2 2 2 1 Leucine-rich repeat ApoB100_C PF12491.8 EFC48262.1 - 0.0038 17.1 2.6 41 4.2 0.0 5.9 4 2 3 7 7 7 0 Apolipoprotein B100 C terminal RHH_3 PF12651.7 EFC48262.1 - 0.016 15.2 0.0 29 4.7 0.0 4.1 3 2 2 5 5 5 0 Ribbon-helix-helix domain DUF424 PF04242.13 EFC48262.1 - 0.026 14.8 6.8 45 4.4 0.1 5.1 1 1 3 4 4 4 0 Protein of unknown function (DUF424) RVT_N PF13655.6 EFC48262.1 - 0.058 13.7 0.0 75 3.7 0.0 3.9 2 1 1 4 4 4 0 N-terminal domain of reverse transcriptase UPF0193 PF05250.11 EFC48262.1 - 0.12 12.1 4.9 2.7 7.7 0.3 3.1 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0193) LRR_6 PF13516.6 EFC48263.1 - 1.8e-36 121.1 25.6 0.00011 21.9 0.0 12.9 13 0 0 13 13 13 8 Leucine Rich repeat LRR_4 PF12799.7 EFC48263.1 - 3.1e-27 94.2 29.6 7e-05 23.1 2.3 8.5 3 2 6 10 10 10 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC48263.1 - 5.4e-27 93.3 26.9 4.8e-08 32.6 0.2 6.3 3 2 4 7 7 7 7 Leucine rich repeat LRR_9 PF14580.6 EFC48263.1 - 5.3e-14 52.1 8.5 4.6e-08 32.8 0.1 3.9 1 1 4 5 5 5 5 Leucine-rich repeat LRR_1 PF00560.33 EFC48263.1 - 1.4e-08 34.1 24.0 2.8 8.8 0.1 11.4 13 2 1 14 14 14 2 Leucine Rich Repeat LRR_5 PF13306.6 EFC48263.1 - 0.00033 20.6 9.4 0.047 13.6 0.2 4.2 1 1 2 4 4 4 3 BspA type Leucine rich repeat region (6 copies) Flg_bb_rod PF00460.20 EFC48263.1 - 0.09 12.7 0.1 0.27 11.2 0.1 1.8 1 0 0 1 1 1 0 Flagella basal body rod protein Beta_helix PF13229.6 EFC48263.1 - 0.74 9.7 9.8 17 5.2 9.2 3.0 1 1 1 2 2 2 0 Right handed beta helix region RICTOR_V PF14668.6 EFC48264.1 - 0.13 12.5 1.4 6.6 7.0 0.0 3.5 3 1 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 RGS PF00615.19 EFC48265.1 - 1.9e-06 28.1 5.8 5.1e-06 26.8 5.8 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ly49 PF08391.10 EFC48265.1 - 0.0029 18.0 10.9 0.0093 16.3 3.7 3.5 2 1 1 3 3 3 1 Ly49-like protein, N-terminal region Jak1_Phl PF17887.1 EFC48265.1 - 0.049 13.6 0.9 1.5 8.8 0.6 2.6 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain AATF-Che1 PF13339.6 EFC48265.1 - 0.19 12.4 2.0 0.26 11.9 0.5 2.0 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor Guanylin PF02058.15 EFC48265.1 - 0.21 12.1 1.6 0.37 11.3 0.1 2.2 2 0 0 2 2 2 0 Guanylin precursor NB PF04159.13 EFC48265.1 - 1.9 8.5 7.8 0.21 11.6 0.7 2.5 2 0 0 2 2 2 0 NB glycoprotein Baculo_11_kDa PF06143.11 EFC48265.1 - 6.3 6.4 9.6 0.59 9.7 2.9 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family Arf PF00025.21 EFC48266.1 - 2.3e-41 141.2 1.5 1.2e-40 138.8 1.5 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC48266.1 - 7.2e-08 32.5 0.1 1.2e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFC48266.1 - 7.6e-08 31.9 9.2 0.00078 18.7 1.8 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFC48266.1 - 1.2e-07 32.0 0.1 2.3e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC48266.1 - 2.3e-07 30.4 1.4 3.8e-07 29.7 1.4 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC48266.1 - 2.7e-06 27.1 2.0 2.9e-05 23.7 2.0 2.0 1 1 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFC48266.1 - 6.3e-06 25.7 3.9 1.3e-05 24.6 3.9 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_15 PF13175.6 EFC48266.1 - 0.00072 19.4 4.4 0.0011 18.8 4.4 1.3 1 0 0 1 1 1 1 AAA ATPase domain 6PF2K PF01591.18 EFC48266.1 - 0.034 13.4 2.3 0.11 11.8 2.3 1.9 1 1 0 1 1 1 0 6-phosphofructo-2-kinase TniB PF05621.11 EFC48266.1 - 0.037 13.4 0.2 0.057 12.8 0.2 1.5 1 1 0 1 1 1 0 Bacterial TniB protein RsgA_GTPase PF03193.16 EFC48266.1 - 0.066 13.1 1.9 5.3 6.9 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 EFC48266.1 - 0.068 13.1 0.3 0.14 12.1 0.3 1.6 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 EFC48266.1 - 0.08 13.5 0.4 0.24 12.0 0.4 2.0 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 EFC48266.1 - 0.11 13.0 2.6 0.99 9.9 2.5 2.0 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 EFC48266.1 - 0.12 11.8 0.4 0.52 9.8 0.0 2.0 2 1 0 2 2 2 0 Ferrous iron transport protein B p450 PF00067.22 EFC48268.1 - 1.8e-48 165.5 0.2 2e-48 165.3 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4139 PF13598.6 EFC48269.1 - 6.5e-21 75.0 2.3 6.5e-21 75.0 2.3 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4139) YebG PF07130.12 EFC48269.1 - 0.027 14.3 1.5 0.066 13.1 1.5 1.6 1 0 0 1 1 1 0 YebG protein ADK PF00406.22 EFC48269.1 - 0.61 10.2 5.4 0.65 10.1 3.8 1.9 2 0 0 2 2 2 0 Adenylate kinase CTK3_C PF12350.8 EFC48269.1 - 7.5 6.8 7.5 2.1 8.6 3.4 2.2 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus NHL PF01436.21 EFC48270.1 - 3.2e-59 194.1 16.0 1.1e-06 28.4 0.1 13.4 12 0 0 12 12 12 11 NHL repeat EGF_2 PF07974.13 EFC48270.1 - 1e-14 54.6 82.0 5.3e-05 23.5 5.9 6.4 6 0 0 6 6 6 5 EGF-like domain SGL PF08450.12 EFC48270.1 - 1.7e-10 40.9 6.1 1.2 8.7 0.1 7.3 2 2 3 5 5 5 2 SMP-30/Gluconolactonase/LRE-like region SBBP PF06739.11 EFC48270.1 - 1.7e-09 37.5 32.9 0.014 15.3 0.3 8.4 8 0 0 8 8 8 4 Beta-propeller repeat Phytase-like PF13449.6 EFC48270.1 - 0.0004 20.4 0.3 49 3.7 0.0 5.7 5 1 1 6 6 6 0 Esterase-like activity of phytase Linker_histone PF00538.19 EFC48270.1 - 0.0038 17.5 0.3 11 6.4 0.0 5.3 7 0 0 7 7 7 1 linker histone H1 and H5 family Reg_prop PF07494.11 EFC48270.1 - 0.0042 17.1 0.9 11 6.6 0.0 6.3 6 0 0 6 6 6 1 Two component regulator propeller TGT_C2 PF14810.6 EFC48270.1 - 0.026 14.6 2.6 31 4.8 0.0 5.9 8 0 0 8 8 8 0 Patch-forming domain C2 of tRNA-guanine transglycosylase DUF4116 PF13475.6 EFC48271.1 - 7.8e-07 28.7 0.9 7.8e-07 28.7 0.9 3.4 3 1 0 4 4 4 1 Domain of unknown function (DUF4116) F-box PF00646.33 EFC48271.1 - 0.00013 21.8 1.3 0.00041 20.1 0.1 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC48271.1 - 0.0025 17.7 0.0 0.0076 16.1 0.0 1.8 1 0 0 1 1 1 1 F-box-like Mpp10 PF04006.12 EFC48271.1 - 0.01 14.3 16.9 0.016 13.7 16.9 1.2 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 EFC48271.1 - 0.011 14.0 19.3 0.014 13.6 19.3 1.1 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 EFC48271.1 - 0.015 14.7 19.8 0.022 14.2 19.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 EFC48271.1 - 0.015 14.7 18.0 0.023 14.2 18.0 1.2 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 EFC48271.1 - 0.033 14.6 0.2 0.053 14.0 0.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Merozoite_SPAM PF07133.11 EFC48271.1 - 0.041 13.9 33.5 0.074 13.0 33.5 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 EFC48271.1 - 0.071 11.4 14.1 0.098 10.9 14.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.13 EFC48271.1 - 0.099 12.5 13.1 0.036 13.9 10.1 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region TRAP_alpha PF03896.16 EFC48271.1 - 0.15 11.3 10.2 0.21 10.7 10.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF913 PF06025.12 EFC48271.1 - 0.16 10.9 3.6 0.26 10.2 3.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC27 PF09507.10 EFC48271.1 - 0.28 10.5 10.0 0.41 10.0 10.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RRN3 PF05327.11 EFC48271.1 - 0.32 9.5 14.1 0.51 8.8 14.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CPSF100_C PF13299.6 EFC48271.1 - 0.32 11.2 4.3 0.59 10.3 4.3 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 EFC48271.1 - 0.39 8.8 32.3 0.59 8.2 32.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi PDCD2_C PF04194.13 EFC48271.1 - 0.7 9.9 10.2 1.3 9.1 10.2 1.6 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Adaptin_binding PF10199.9 EFC48271.1 - 0.98 10.0 14.9 2.5 8.7 15.0 1.7 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 TFIIA PF03153.13 EFC48271.1 - 1.1 9.2 17.5 1.5 8.8 16.7 1.6 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit PPL5 PF18168.1 EFC48271.1 - 1.3 8.2 7.3 2 7.6 7.3 1.2 1 0 0 1 1 1 0 Prim-pol family 5 RPN2_C PF18004.1 EFC48271.1 - 1.4 8.8 10.6 2.9 7.8 10.6 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Astro_capsid_p PF12226.8 EFC48271.1 - 1.7 7.8 17.7 2.4 7.2 17.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Presenilin PF01080.17 EFC48271.1 - 1.9 7.2 4.5 2.7 6.6 4.5 1.2 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 EFC48271.1 - 2 8.7 17.7 3.8 7.8 17.7 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop53 PF07767.11 EFC48271.1 - 2.3 7.5 17.3 3.3 7.0 17.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Paf1 PF03985.13 EFC48271.1 - 2.3 7.1 19.9 3.4 6.6 19.9 1.2 1 0 0 1 1 1 0 Paf1 BUD22 PF09073.10 EFC48271.1 - 3 7.1 20.4 4.6 6.5 20.4 1.2 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 EFC48271.1 - 3.6 6.7 6.7 5.3 6.2 6.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TFB6 PF17110.5 EFC48271.1 - 3.8 7.2 11.0 7.7 6.2 11.0 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2722 PF10846.8 EFC48271.1 - 7 5.5 11.8 11 4.8 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Tim54 PF11711.8 EFC48271.1 - 7.5 5.2 9.1 12 4.6 9.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 BTV_NS2 PF04514.12 EFC48271.1 - 7.9 5.2 11.8 13 4.5 11.8 1.3 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 DUF4504 PF14953.6 EFC48273.1 - 6.2e-83 278.2 8.3 7.8e-83 277.9 8.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4504) Aldolase_II PF00596.21 EFC48274.1 - 4.3e-41 140.9 0.0 5.3e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain UPF0047 PF01894.17 EFC48274.1 - 0.077 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 Adap_comp_sub PF00928.21 EFC48275.1 - 3.8e-68 229.7 0.1 4.8e-68 229.4 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFC48275.1 - 1.6e-12 47.5 2.9 3.2e-12 46.6 2.9 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Hydrolase_4 PF12146.8 EFC48276.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Rhodanese PF00581.20 EFC48277.1 - 4e-05 24.1 0.1 7.5e-05 23.2 0.1 1.5 1 1 0 1 1 1 1 Rhodanese-like domain Amidohydro_1 PF01979.20 EFC48278.1 - 3.3e-19 69.4 0.9 1.3e-09 37.9 0.0 3.4 3 0 0 3 3 3 3 Amidohydrolase family Amidohydro_3 PF07969.11 EFC48278.1 - 5.3e-13 49.3 0.1 8.8e-05 22.2 0.0 3.3 3 0 0 3 3 3 3 Amidohydrolase family DUF3149 PF11346.8 EFC48278.1 - 0.073 12.7 1.1 0.19 11.4 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) DUF3953 PF13129.6 EFC48278.1 - 0.21 11.4 2.1 0.41 10.4 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) Actin PF00022.19 EFC48279.1 - 6.1e-12 44.8 0.0 1.1e-05 24.3 0.0 2.4 2 0 0 2 2 2 2 Actin 2OG-FeII_Oxy_3 PF13640.6 EFC48279.1 - 1.6e-06 28.9 0.0 4.4e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EFC48279.1 - 0.0094 15.8 0.1 0.045 13.7 0.0 2.2 2 0 0 2 2 2 1 F-box-like TetR_C_8 PF14278.6 EFC48279.1 - 0.011 15.8 0.5 2.7 8.1 0.1 3.1 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region PRANC PF09372.10 EFC48279.1 - 1.2 9.5 6.2 3.2 8.1 2.8 3.3 2 1 0 2 2 2 0 PRANC domain F-box-like PF12937.7 EFC48280.1 - 0.00063 19.6 0.1 0.0029 17.5 0.0 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC48280.1 - 0.00099 18.9 0.0 0.0033 17.3 0.0 1.9 2 0 0 2 2 2 1 F-box domain Actin PF00022.19 EFC48282.1 - 9.6e-81 271.5 0.0 1.2e-79 267.8 0.0 1.9 1 1 0 1 1 1 1 Actin DUF4116 PF13475.6 EFC48283.1 - 2.4e-59 196.8 1.2 2.5e-13 49.5 0.0 7.9 3 2 3 8 8 8 6 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC48283.1 - 8.6e-26 90.9 7.3 8.6e-26 90.9 7.3 2.4 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48283.1 - 3.3e-08 33.1 0.3 3.3e-08 33.1 0.3 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase NYD-SP28_assoc PF14775.6 EFC48283.1 - 0.00058 19.9 1.7 0.0027 17.8 1.7 2.2 1 0 0 1 1 1 1 Sperm tail C-terminal domain Kdo PF06293.14 EFC48283.1 - 0.033 13.5 0.2 0.073 12.4 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family 2OG-FeII_Oxy_3 PF13640.6 EFC48284.1 - 1e-08 36.0 0.0 1.6e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 EFC48284.1 - 0.099 13.1 0.0 0.49 10.8 0.0 2.0 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Organ_specific PF10950.8 EFC48285.1 - 0.012 16.3 3.3 0.025 15.3 3.3 1.5 1 0 0 1 1 1 0 Organ specific protein 5_3_exonuc PF01367.20 EFC48285.1 - 0.03 14.9 3.0 0.061 13.9 3.0 1.5 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold zf-UBP PF02148.19 EFC48285.1 - 0.49 10.8 1.8 20 5.6 0.0 2.4 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein VWA PF00092.28 EFC48286.1 - 1.9e-08 34.8 0.1 3.8e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC48286.1 - 3.5e-08 34.0 0.1 1.1e-07 32.5 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC48286.1 - 4.9e-05 23.3 0.0 7.5e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain PI-PLC-X PF00388.19 EFC48287.1 - 6e-05 22.7 0.1 0.0001 21.9 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Varsurf_PPLC PF03490.13 EFC48287.1 - 0.0008 19.3 0.0 0.0026 17.7 0.0 1.8 1 0 0 1 1 1 1 Variant-surface-glycoprotein phospholipase C RST PF12174.8 EFC48287.1 - 0.14 12.1 0.0 13 5.8 0.0 2.6 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Kelch_4 PF13418.6 EFC48288.1 - 3.2e-33 113.5 3.2 4.6e-07 29.7 0.0 6.3 5 1 1 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC48288.1 - 1.2e-32 111.2 0.1 5.3e-06 25.9 0.0 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 EFC48288.1 - 8.1e-30 102.5 0.0 0.00024 21.3 0.0 7.0 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC48288.1 - 1.9e-23 82.0 0.0 0.0023 17.9 0.0 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 EFC48288.1 - 7.5e-23 80.0 0.5 0.0015 18.8 0.0 6.3 5 1 1 6 6 6 5 Kelch motif Kelch_2 PF07646.15 EFC48288.1 - 4.4e-21 74.0 7.3 0.00076 19.4 0.0 6.6 6 0 0 6 6 6 5 Kelch motif F-box-like PF12937.7 EFC48289.1 - 0.00057 19.7 0.0 0.0015 18.3 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48289.1 - 0.0085 15.9 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain His_Phos_2 PF00328.22 EFC48290.1 - 3.1e-11 43.2 0.0 5.3e-06 26.0 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) GlutR_dimer PF00745.20 EFC48291.1 - 0.068 13.6 0.5 1.9 9.0 0.1 2.3 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Amino_oxidase PF01593.24 EFC48292.1 - 8.8e-43 147.2 0.0 7.4e-41 140.9 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC48292.1 - 1.2e-08 35.0 0.1 2.6e-08 34.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 EFC48292.1 - 2.8e-05 23.4 0.1 4.7e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EFC48292.1 - 3.1e-05 23.3 0.1 8.3e-05 22.0 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC48292.1 - 0.00044 19.1 0.4 0.0029 16.4 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 EFC48292.1 - 0.00089 18.4 0.2 0.0014 17.8 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 EFC48292.1 - 0.003 16.9 0.5 0.0076 15.5 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 EFC48292.1 - 0.0038 16.5 0.9 0.008 15.5 0.2 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 EFC48292.1 - 0.0091 15.3 0.1 0.019 14.3 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 EFC48292.1 - 0.0098 15.5 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC48292.1 - 0.017 14.4 0.1 0.032 13.5 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 EFC48292.1 - 0.057 14.0 0.5 0.18 12.4 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC48292.1 - 0.063 12.3 0.1 0.087 11.9 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 EFC48292.1 - 0.078 12.3 0.1 0.12 11.7 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 EFC48292.1 - 0.17 11.9 0.1 0.34 10.9 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding PLATZ PF04640.14 EFC48293.1 - 0.92 10.2 10.4 0.77 10.4 2.1 2.7 3 0 0 3 3 3 0 PLATZ transcription factor RNA_pol_N PF01194.17 EFC48293.1 - 2.2 8.7 4.5 0.92 9.9 0.5 2.2 2 0 0 2 2 2 0 RNA polymerases N / 8 kDa subunit TPR_9 PF13371.6 EFC48294.1 - 6.1e-07 29.5 0.0 0.00013 22.0 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48294.1 - 1.2e-06 28.1 17.8 0.13 12.4 0.5 6.9 4 2 2 7 7 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48294.1 - 3e-06 26.8 26.4 0.028 14.2 0.9 7.2 7 1 1 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC48294.1 - 7.7e-06 26.1 9.8 0.00067 19.8 1.1 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 EFC48294.1 - 0.00013 22.6 2.7 0.37 11.5 0.0 4.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48294.1 - 0.00032 21.1 0.4 0.54 10.8 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat HECT PF00632.25 EFC48294.1 - 0.0031 17.0 0.2 0.005 16.4 0.2 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TPR_12 PF13424.6 EFC48294.1 - 0.0084 16.4 8.2 6 7.2 1.9 4.7 5 1 0 5 5 5 2 Tetratricopeptide repeat OEP PF02321.18 EFC48294.1 - 0.029 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 Outer membrane efflux protein RPN7 PF10602.9 EFC48294.1 - 0.12 12.0 3.7 1.4 8.6 0.1 3.2 2 2 1 3 3 3 0 26S proteasome subunit RPN7 TPR_6 PF13174.6 EFC48294.1 - 6.2 7.7 11.9 22 6.0 0.1 5.5 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48294.1 - 6.7 7.2 15.8 19 5.8 0.5 5.6 5 1 0 5 5 5 0 Tetratricopeptide repeat TGT PF01702.18 EFC48295.1 - 4.8e-87 292.4 0.2 1.9e-56 191.7 0.0 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase Ribosomal_L22e PF01776.17 EFC48296.1 - 4e-38 130.1 6.3 5.2e-38 129.8 6.3 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family PAC2 PF09754.9 EFC48298.1 - 4.6e-10 39.9 0.0 6.5e-10 39.4 0.0 1.3 1 1 0 1 1 1 1 PAC2 family Methyltransf_28 PF02636.17 EFC48299.1 - 1e-32 113.9 0.7 1.8e-32 113.0 0.7 1.4 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MACPF PF01823.19 EFC48300.1 - 4e-07 30.3 1.4 0.0095 16.0 0.1 2.4 1 1 1 2 2 2 2 MAC/Perforin domain NHL PF01436.21 EFC48301.1 - 1.1e-12 47.3 2.8 0.0013 18.7 0.1 4.7 5 0 0 5 5 5 3 NHL repeat EGF_2 PF07974.13 EFC48302.1 - 9.7e-45 150.6 235.0 5.8e-05 23.4 8.0 15.5 15 0 0 15 15 15 14 EGF-like domain Pkinase PF00069.25 EFC48302.1 - 9.4e-40 136.6 0.1 1.6e-38 132.6 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48302.1 - 2.2e-29 102.5 0.8 4.8e-24 85.0 0.0 2.7 1 1 0 2 2 2 2 Protein tyrosine kinase EGF PF00008.27 EFC48302.1 - 7e-13 48.6 168.2 0.00094 19.4 4.3 15.7 15 0 0 15 15 15 11 EGF-like domain EF-hand_1 PF00036.32 EFC48303.1 - 5.4e-12 44.4 6.4 1.7e-05 24.0 0.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC48303.1 - 1.3e-11 44.8 4.3 2e-11 44.2 4.3 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 EFC48303.1 - 3.3e-10 39.0 3.5 0.0001 21.9 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 EFC48303.1 - 4.1e-08 32.4 6.2 0.00016 21.0 0.4 2.5 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 EFC48303.1 - 4.7e-08 32.7 6.0 1.8e-06 27.7 1.5 2.4 1 1 1 2 2 2 2 EF-hand domain pair Guanylate_cyc PF00211.20 EFC48304.1 - 4.5e-48 163.3 0.0 5.3e-48 163.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_5 PF13306.6 EFC48304.1 - 0.019 14.9 0.5 0.032 14.2 0.5 1.3 1 0 0 1 1 1 0 BspA type Leucine rich repeat region (6 copies) Peptidase_C93 PF06035.11 EFC48304.1 - 0.12 12.1 0.0 5.6 6.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial transglutaminase-like cysteine proteinase BTLCP ABC_tran PF00005.27 EFC48305.1 - 8.2e-22 78.2 0.3 1.1e-21 77.7 0.3 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC48305.1 - 6e-08 32.4 2.5 4.3e-07 29.6 2.5 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 EFC48305.1 - 0.0059 16.5 0.7 0.011 15.7 0.3 1.6 1 1 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 EFC48305.1 - 0.038 13.6 0.1 0.078 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFC48305.1 - 0.14 12.3 0.0 0.41 10.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain PRAS PF15798.5 EFC48306.1 - 0.59 10.7 8.6 0.071 13.7 3.5 2.1 2 1 0 2 2 2 0 Proline-rich AKT1 substrate 1 SHIPPO-rpt PF07004.12 EFC48307.1 - 2.8e-08 34.3 63.7 0.025 15.5 0.1 8.9 9 2 0 9 9 9 6 Sperm-tail PG-rich repeat MORN PF02493.20 EFC48308.1 - 3.1e-19 67.6 37.6 3.9e-06 26.4 1.0 5.2 5 0 0 5 5 5 4 MORN repeat RCC1 PF00415.18 EFC48309.1 - 4.3e-58 193.7 17.5 5e-13 49.5 0.1 7.9 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC48309.1 - 4.1e-21 74.3 25.6 7.3e-08 32.0 0.5 7.9 8 1 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat FtsJ PF01728.19 EFC48310.1 - 1.6e-47 161.9 0.0 2.1e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EFC48310.1 - 0.0063 16.3 0.0 0.069 13.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC48310.1 - 0.0089 15.4 0.0 0.057 12.7 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC48310.1 - 0.078 12.8 0.0 0.24 11.2 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Methyltrans_Mon PF14314.6 EFC48310.1 - 0.086 10.9 0.0 0.11 10.5 0.0 1.1 1 0 0 1 1 1 0 Virus-capping methyltransferase LRR_6 PF13516.6 EFC48312.1 - 4e-22 76.3 2.5 7.1e-06 25.7 0.0 4.3 4 0 0 4 4 4 4 Leucine Rich repeat LRR_8 PF13855.6 EFC48312.1 - 1.6e-13 50.2 5.1 4.2e-08 32.8 0.4 2.4 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC48312.1 - 2.3e-13 50.1 0.4 8.6e-06 26.0 0.1 2.9 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48312.1 - 7.6e-09 34.9 0.0 0.2 12.3 0.0 4.2 4 0 0 4 4 4 4 Leucine Rich Repeat AAA_6 PF12774.7 EFC48313.1 - 1.3e-134 448.3 1.3 1.1e-133 445.2 0.0 3.5 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC48313.1 - 9e-110 367.5 14.5 9e-110 367.5 14.5 8.4 8 3 1 9 9 8 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFC48313.1 - 1.5e-72 244.0 0.0 1.8e-71 240.5 0.0 3.1 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 EFC48313.1 - 1.4e-70 236.8 1.9 1.4e-70 236.8 1.9 4.2 4 0 0 4 4 2 1 ATP-binding dynein motor region DHC_N1 PF08385.12 EFC48313.1 - 9.5e-67 225.9 36.9 9.5e-67 225.9 36.9 6.7 6 2 0 6 6 5 1 Dynein heavy chain, N-terminal region 1 AAA_7 PF12775.7 EFC48313.1 - 1.2e-40 139.0 0.0 1.5e-35 122.4 0.0 4.8 4 0 0 4 4 4 1 P-loop containing dynein motor region Dynein_C PF18199.1 EFC48313.1 - 6.7e-35 120.8 0.4 6.7e-35 120.8 0.4 2.6 3 0 0 3 3 2 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 EFC48313.1 - 1.4e-31 109.5 0.0 4.9e-31 107.8 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 EFC48313.1 - 4.7e-30 104.4 0.0 9.4e-10 38.6 0.0 6.5 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) MT PF12777.7 EFC48313.1 - 1.4e-29 103.2 6.8 3.3e-29 102.0 6.8 1.7 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 EFC48313.1 - 8.9e-27 93.6 0.3 7.4e-25 87.3 0.0 3.9 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 EFC48313.1 - 4.1e-17 62.9 0.0 4.2e-05 24.0 0.0 5.1 4 0 0 4 4 3 3 ATPase family associated with various cellular activities (AAA) Dynein_AAA_lid PF17852.1 EFC48313.1 - 4.3e-16 59.2 5.8 6.3e-16 58.6 0.4 3.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 EFC48313.1 - 1.6e-14 54.4 0.0 0.0039 17.5 0.0 6.5 5 0 0 5 5 5 3 AAA domain AAA_16 PF13191.6 EFC48313.1 - 3.7e-10 40.4 0.8 0.31 11.4 0.0 6.2 5 1 1 6 6 5 2 AAA ATPase domain AAA_18 PF13238.6 EFC48313.1 - 7.2e-09 36.3 4.7 0.06 13.9 0.0 6.4 6 0 0 6 6 4 2 AAA domain AAA_33 PF13671.6 EFC48313.1 - 1.2e-08 35.2 0.2 0.2 11.8 0.0 5.4 5 0 0 5 5 4 2 AAA domain RNA_helicase PF00910.22 EFC48313.1 - 1.1e-05 25.7 0.7 5.8 7.4 0.0 5.5 5 0 0 5 5 4 0 RNA helicase T2SSE PF00437.20 EFC48313.1 - 5.5e-05 22.4 0.0 0.5 9.4 0.0 4.0 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_29 PF13555.6 EFC48313.1 - 0.00019 21.1 0.1 1.3 8.8 0.0 3.4 3 0 0 3 3 3 2 P-loop containing region of AAA domain IstB_IS21 PF01695.17 EFC48313.1 - 0.0002 21.2 0.1 0.027 14.2 0.0 3.7 4 0 0 4 4 3 1 IstB-like ATP binding protein AAA_lid_1 PF17857.1 EFC48313.1 - 0.0002 21.5 2.1 0.00082 19.6 0.1 3.3 3 0 0 3 3 1 1 AAA+ lid domain BRE1 PF08647.11 EFC48313.1 - 0.0002 21.3 7.1 0.0002 21.3 7.1 8.9 12 0 0 12 12 4 2 BRE1 E3 ubiquitin ligase AAA_25 PF13481.6 EFC48313.1 - 0.00083 19.0 0.0 0.016 14.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain SPK PF04435.18 EFC48313.1 - 0.0013 19.1 0.7 0.059 13.8 0.5 4.3 2 0 0 2 2 1 1 Domain of unknown function (DUF545) AAA_30 PF13604.6 EFC48313.1 - 0.0016 18.2 0.1 3.7 7.2 0.0 3.9 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.6 EFC48313.1 - 0.002 17.9 0.0 11 5.6 0.0 4.7 4 0 0 4 4 3 0 AAA domain Mg_chelatase PF01078.21 EFC48313.1 - 0.0027 17.1 0.3 0.73 9.2 0.0 3.5 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI POT1PC PF16686.5 EFC48313.1 - 0.0067 16.3 0.6 0.024 14.5 0.1 2.3 2 0 0 2 2 1 1 ssDNA-binding domain of telomere protection protein FtsK_SpoIIIE PF01580.18 EFC48313.1 - 0.016 14.6 0.0 1.4 8.3 0.0 3.3 3 0 0 3 3 2 0 FtsK/SpoIIIE family RuvB_N PF05496.12 EFC48313.1 - 0.018 14.8 0.0 0.56 10.0 0.0 3.2 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 EFC48313.1 - 0.019 15.3 0.0 16 5.8 0.0 4.2 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EFC48313.1 - 0.058 13.1 0.0 9 6.0 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.12 EFC48313.1 - 0.064 13.2 2.7 35 4.3 0.0 4.5 4 0 0 4 4 3 0 NACHT domain Radical_SAM PF04055.21 EFC48314.1 - 3.7e-30 105.5 0.0 6.2e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 EFC48314.1 - 2.7e-29 101.1 1.0 4.4e-29 100.4 0.1 1.8 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 Fer4_12 PF13353.6 EFC48314.1 - 0.072 13.4 0.1 0.3 11.3 0.0 2.1 2 0 0 2 2 2 0 4Fe-4S single cluster domain RRM_1 PF00076.22 EFC48315.1 - 6.7e-42 141.2 0.5 2.3e-21 75.4 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC48315.1 - 5.7e-08 32.5 0.0 0.0029 17.4 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 EFC48315.1 - 2e-06 27.8 0.1 0.00024 21.2 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif DUF1866 PF08952.11 EFC48315.1 - 4.9e-05 23.2 0.1 0.11 12.3 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF1866) Nup35_RRM_2 PF14605.6 EFC48315.1 - 0.00011 22.1 0.0 0.0082 16.1 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 EFC48315.1 - 0.031 14.5 11.7 0.73 10.0 0.0 4.0 2 1 3 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.25 EFC48316.1 - 7e-27 94.4 0.5 1.1e-26 93.9 0.5 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48316.1 - 7.2e-15 55.0 0.5 7.4e-14 51.7 0.5 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Aminotran_5 PF00266.19 EFC48317.1 - 4.6e-25 88.4 0.0 2.8e-23 82.5 0.0 2.9 2 1 0 2 2 2 2 Aminotransferase class-V WD40 PF00400.32 EFC48318.1 - 0.0001 23.0 0.2 0.47 11.4 0.0 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat DUF4834 PF16118.5 EFC48318.1 - 0.013 16.5 1.5 0.39 11.7 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PK PF00224.21 EFC48319.1 - 9.6e-139 462.1 20.8 1.8e-110 369.1 5.4 2.8 2 1 1 3 3 3 2 Pyruvate kinase, barrel domain PK_C PF02887.16 EFC48319.1 - 3.2e-31 108.0 4.6 4.5e-31 107.5 3.2 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 EFC48319.1 - 0.0012 18.0 0.3 0.0029 16.8 0.3 1.7 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family SRF-TF PF00319.18 EFC48320.1 - 8.5e-21 73.2 0.1 2e-20 72.0 0.1 1.7 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) AP3D1 PF06375.11 EFC48320.1 - 0.0093 16.2 3.9 0.0093 16.2 3.9 2.5 2 0 0 2 2 2 1 AP-3 complex subunit delta-1 Dsh_C PF12316.8 EFC48320.1 - 3.8 7.9 27.4 0.29 11.5 11.3 2.1 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Suf PF05843.14 EFC48320.1 - 4.7 7.1 13.8 1.1 9.2 4.7 2.2 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) RIBIOP_C PF04950.12 EFC48321.1 - 2.1e-81 273.5 0.4 2.1e-81 273.5 0.4 3.2 3 0 0 3 3 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 EFC48321.1 - 1.5e-28 98.7 0.0 6.9e-28 96.6 0.0 2.3 1 0 0 1 1 1 1 AARP2CN (NUC121) domain PduV-EutP PF10662.9 EFC48321.1 - 1.5e-05 24.8 0.1 3.9e-05 23.4 0.1 1.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EFC48321.1 - 0.00025 21.5 0.1 0.0038 17.6 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) GTP_EFTU PF00009.27 EFC48321.1 - 0.00077 19.0 1.8 0.19 11.3 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC48321.1 - 0.0015 18.6 0.2 0.02 15.0 0.2 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC48321.1 - 0.0017 18.7 0.0 0.006 16.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC48321.1 - 0.005 17.0 0.0 0.022 14.9 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC48321.1 - 0.0077 16.6 0.6 0.029 14.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 EFC48321.1 - 0.059 13.6 0.1 0.4 10.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFC48321.1 - 0.068 13.6 0.3 0.33 11.4 0.0 2.4 2 0 0 2 2 2 0 RNA helicase MobB PF03205.14 EFC48321.1 - 0.15 12.0 2.5 0.24 11.3 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.6 EFC48321.1 - 0.4 10.7 0.0 0.4 10.7 0.0 3.5 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFC48321.1 - 0.52 10.8 0.0 0.52 10.8 0.0 4.6 4 2 1 5 5 3 0 ABC transporter Kinesin PF00225.23 EFC48322.1 - 2.2e-57 194.5 1.9 2.2e-57 194.5 1.9 5.0 4 2 0 6 6 6 1 Kinesin motor domain Microtub_bd PF16796.5 EFC48322.1 - 4.3e-21 75.4 0.2 4.3e-21 75.4 0.2 4.1 3 2 1 4 4 4 1 Microtubule binding Ras PF00071.22 EFC48323.1 - 3.2e-16 59.4 0.0 3.5e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48323.1 - 6.1e-13 49.0 0.0 6.9e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 EFC48323.1 - 0.086 12.2 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RNA_pol_3_Rpc31 PF11705.8 EFC48324.1 - 0.0012 19.1 30.8 4.8 7.4 30.8 2.8 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 DUF220 PF02713.14 EFC48324.1 - 0.043 13.9 0.0 6.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF220 ubiquitin PF00240.23 EFC48326.1 - 6.3e-64 211.7 5.9 5.4e-32 109.4 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC48326.1 - 4.3e-30 103.3 7.1 3.6e-15 55.5 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 EFC48326.1 - 4.8e-09 36.3 0.3 0.0013 18.8 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC48326.1 - 5.2e-09 36.4 3.3 0.0029 18.0 0.3 3.0 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC48326.1 - 6.3e-09 35.7 0.4 0.0019 18.1 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 EFC48326.1 - 2.9e-07 31.0 0.1 0.0077 16.8 0.0 2.2 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC48326.1 - 6.2e-07 29.7 1.7 0.025 14.9 0.2 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC48326.1 - 3.3e-05 23.8 7.0 3.4 7.8 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain ProRS-C_2 PF09181.10 EFC48326.1 - 0.073 13.2 0.5 16 5.7 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal DUF366 PF04017.12 EFC48326.1 - 0.076 12.5 0.0 6.4 6.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF366) PilN_bio_d PF18222.1 EFC48326.1 - 0.18 12.2 0.1 6.8 7.1 0.0 2.1 2 0 0 2 2 2 0 PilN biogenesis protein dimerization domain bPH_3 PF14470.6 EFC48326.1 - 0.18 12.2 1.7 5.4 7.5 0.2 2.9 3 0 0 3 3 3 0 Bacterial PH domain PI3K_rbd PF00794.18 EFC48326.1 - 0.24 11.6 1.6 2.5 8.3 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain DUF4362 PF14275.6 EFC48327.1 - 0.019 15.2 0.6 0.98 9.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4362) E1_dh PF00676.20 EFC48328.1 - 3.9e-66 223.0 0.0 5.5e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Transket_pyr PF02779.24 EFC48328.1 - 9.7e-64 214.3 0.0 1.9e-63 213.3 0.0 1.5 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain OxoGdeHyase_C PF16870.5 EFC48328.1 - 2.9e-53 179.7 0.0 4.9e-53 178.9 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 EFC48328.1 - 6.1e-12 44.9 0.7 6.1e-12 44.9 0.7 2.0 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus Ntox11 PF15521.6 EFC48329.1 - 1.7e-40 139.4 0.3 3e-40 138.5 0.3 1.3 1 0 0 1 1 1 1 Novel toxin 11 Ectoine_synth PF06339.12 EFC48329.1 - 0.044 14.0 0.1 0.098 12.9 0.1 1.5 1 0 0 1 1 1 0 Ectoine synthase Fimbrial_K88 PF02432.15 EFC48329.1 - 0.82 9.6 3.9 1.2 9.1 0.4 2.5 2 1 1 3 3 3 0 Fimbrial, major and minor subunit Ufd2P_core PF10408.9 EFC48330.1 - 2.2e-172 574.9 20.4 3.5e-172 574.3 20.4 1.3 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 EFC48330.1 - 5.9e-25 87.2 0.8 5.9e-25 87.2 0.8 2.6 2 0 0 2 2 2 1 U-box domain DUF4274 PF14096.6 EFC48330.1 - 0.069 13.1 0.1 0.2 11.6 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4274) Histone_HNS PF00816.21 EFC48330.1 - 0.18 12.6 3.5 72 4.3 0.0 4.1 5 0 0 5 5 5 0 H-NS histone family BolA PF01722.18 EFC48331.1 - 1.6e-14 53.9 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 BolA-like protein MCU PF04678.13 EFC48332.1 - 0.0003 20.9 0.8 0.0003 20.9 0.8 1.7 2 1 0 2 2 2 1 Mitochondrial calcium uniporter DUF2368 PF10166.9 EFC48332.1 - 0.018 14.6 1.6 0.033 13.8 0.7 1.8 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) FKBP_N PF01346.18 EFC48332.1 - 2.3 9.3 6.3 1.4 9.9 2.2 2.4 2 1 0 3 3 3 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Auxin_canalis PF05703.11 EFC48332.1 - 3.4 7.5 5.4 7.4 6.4 5.4 1.4 1 0 0 1 1 1 0 Auxin canalisation Atrophin-1 PF03154.15 EFC48332.1 - 6.4 4.9 8.5 8.4 4.5 8.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Tfb4 PF03850.14 EFC48333.1 - 0.0025 17.3 0.5 0.0039 16.7 0.5 1.3 1 0 0 1 1 1 1 Transcription factor Tfb4 LMBR1 PF04791.16 EFC48333.1 - 0.0069 15.4 0.5 0.0093 14.9 0.5 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF1420 PF07220.11 EFC48333.1 - 0.043 12.4 0.2 0.078 11.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1420) DUF4446 PF14584.6 EFC48333.1 - 0.14 12.1 7.8 0.51 10.3 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4834 PF16118.5 EFC48333.1 - 0.23 12.5 9.6 3.5 8.7 3.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Fib_alpha PF08702.10 EFC48333.1 - 0.87 9.8 9.3 0.044 14.0 2.5 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Uds1 PF15456.6 EFC48333.1 - 1.6 8.9 9.9 0.12 12.5 4.7 1.7 2 0 0 2 2 2 0 Up-regulated During Septation PRC2_HTH_1 PF18118.1 EFC48333.1 - 3.3 8.6 10.3 0.35 11.7 3.8 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain ubiquitin PF00240.23 EFC48335.1 - 2e-64 213.3 6.5 1.7e-32 110.9 0.6 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC48335.1 - 7.7e-31 105.7 7.6 1.2e-15 57.1 0.7 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC48335.1 - 1.8e-09 38.0 3.7 0.0015 19.0 0.2 3.0 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC48335.1 - 7.5e-09 35.7 0.4 0.00095 19.3 0.1 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC48335.1 - 8.3e-09 35.3 0.4 0.0018 18.1 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 EFC48335.1 - 1.3e-07 31.9 1.7 0.0081 16.5 0.1 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC48335.1 - 3.2e-07 30.9 0.1 0.0078 16.8 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC48335.1 - 4.5e-05 23.4 7.2 2.6 8.2 0.2 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain ProRS-C_2 PF09181.10 EFC48335.1 - 0.036 14.2 0.5 7.7 6.7 0.1 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal Raf1_HTH PF18579.1 EFC48335.1 - 0.052 13.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain DUF1866 PF08952.11 EFC48335.1 - 0.054 13.3 0.1 9.3 6.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) UN_NPL4 PF11543.8 EFC48335.1 - 0.076 13.5 0.3 5.3 7.6 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 ACT_5 PF13710.6 EFC48335.1 - 0.14 12.1 0.5 2.8 7.9 0.1 2.3 2 0 0 2 2 2 0 ACT domain bPH_3 PF14470.6 EFC48335.1 - 0.16 12.3 2.6 2.3 8.6 0.2 2.8 3 0 0 3 3 3 0 Bacterial PH domain PilN_bio_d PF18222.1 EFC48335.1 - 0.17 12.3 0.1 7.2 7.1 0.0 2.1 2 0 0 2 2 2 0 PilN biogenesis protein dimerization domain PI3K_rbd PF00794.18 EFC48335.1 - 0.19 11.9 1.8 2 8.6 0.3 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain Peptidase_M16_M PF16187.5 EFC48336.1 - 8.2e-70 235.3 4.0 8.2e-70 235.3 4.0 1.8 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 EFC48336.1 - 4e-39 134.0 1.4 1.5e-38 132.1 0.2 2.5 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 EFC48336.1 - 1.4e-27 96.9 2.4 1.4e-15 57.8 0.1 3.6 3 0 0 3 3 3 2 Peptidase M16 inactive domain DnaB_2 PF07261.11 EFC48338.1 - 0.055 13.2 0.5 0.34 10.7 0.1 2.5 1 1 1 2 2 2 0 Replication initiation and membrane attachment DUF3024 PF11225.8 EFC48339.1 - 0.14 12.4 0.2 0.61 10.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3024) DHHA1 PF02272.19 EFC48339.1 - 4.3 7.7 6.0 2.3 8.6 3.0 2.1 2 0 0 2 2 2 0 DHHA1 domain TUTF7_u4 PF16631.5 EFC48340.1 - 5.3 7.7 8.3 8.8e+02 0.6 8.3 3.0 1 1 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 SIR2 PF02146.17 EFC48343.1 - 9.4e-30 103.8 0.1 6.7e-27 94.6 0.1 2.2 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 EFC48343.1 - 0.028 14.1 0.0 2.8 7.7 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain HTH_52 PF18576.1 EFC48343.1 - 0.1 12.8 0.9 0.64 10.3 0.1 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain Put_Phosphatase PF06888.12 EFC48344.1 - 2.7e-54 184.0 6.1 3.2e-54 183.8 6.1 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 EFC48344.1 - 4.5e-09 37.0 0.0 1.8e-08 35.0 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFC48344.1 - 2.8e-07 30.8 2.3 1.6e-05 25.1 2.3 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC48344.1 - 0.028 14.2 3.1 0.79 9.4 0.6 2.9 1 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase 2-oxoacid_dh PF00198.23 EFC48345.1 - 1.1e-83 280.2 0.2 8.9e-83 277.3 0.0 2.3 3 0 0 3 3 3 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFC48345.1 - 6.2e-19 67.6 0.4 1.3e-18 66.6 0.4 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 EFC48345.1 - 1.2e-15 57.5 0.3 3.2e-15 56.2 0.1 1.9 2 0 0 2 2 2 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 EFC48345.1 - 0.0002 21.1 0.1 0.02 14.7 0.0 2.5 2 0 0 2 2 2 1 Biotin-lipoyl like Spa1_C PF18218.1 EFC48345.1 - 0.021 15.2 0.0 0.081 13.3 0.0 2.0 1 0 0 1 1 1 0 Lantibiotic immunity protein Spa1 C-terminal domain HlyD_3 PF13437.6 EFC48345.1 - 0.11 13.2 0.1 5.5 7.8 0.0 2.5 1 1 1 2 2 2 0 HlyD family secretion protein Pirin_C PF05726.13 EFC48347.1 - 1.5e-26 92.8 0.0 5.2e-25 87.8 0.0 2.7 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Pirin PF02678.16 EFC48347.1 - 4.1e-26 91.1 0.0 9.9e-26 89.8 0.0 1.7 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.11 EFC48347.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Baculo_IE-1 PF05290.11 EFC48348.1 - 0.032 14.2 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Pet127 PF08634.10 EFC48349.1 - 2.3e-85 286.4 0.8 2.3e-85 286.4 0.8 2.4 2 1 1 3 3 3 1 Mitochondrial protein Pet127 GST_C_3 PF14497.6 EFC48351.1 - 4.5e-14 52.4 0.1 6.9e-14 51.8 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC48351.1 - 1.3e-07 31.9 0.0 2.1e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC48351.1 - 7.9e-06 26.0 0.1 1.3e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC48351.1 - 0.00013 21.9 0.0 0.00024 21.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Exo5 PF09810.9 EFC48351.1 - 0.066 12.7 0.0 0.069 12.6 0.0 1.1 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease GST_C_3 PF14497.6 EFC48352.1 - 1.6e-14 53.8 0.0 3e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC48352.1 - 2.2e-06 27.9 0.1 5.7e-06 26.6 0.1 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC48352.1 - 0.00011 22.3 0.1 0.00032 20.8 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 EFC48352.1 - 0.0019 18.5 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 EFC48352.1 - 0.0053 16.8 0.0 0.01 15.9 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 EFC48352.1 - 0.011 16.5 0.0 0.02 15.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 EFC48352.1 - 0.07 13.4 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Ferritin-like PF12902.7 EFC48353.1 - 0.0061 16.5 0.0 0.0082 16.0 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like Glyco_hydro_18 PF00704.28 EFC48353.1 - 0.059 13.1 0.1 0.068 12.9 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 DUF4886 PF16227.5 EFC48353.1 - 0.12 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) DUF3783 PF12646.7 EFC48353.1 - 0.17 11.9 0.3 0.52 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) ABC_tran PF00005.27 EFC48354.1 - 2.9e-25 89.4 0.0 3.9e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 EFC48354.1 - 1.3e-05 25.2 0.1 0.0051 16.7 0.1 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 EFC48354.1 - 3.9e-05 24.2 0.7 8.2e-05 23.2 0.6 1.6 1 1 1 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 EFC48354.1 - 0.00012 22.0 0.0 0.00024 21.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 EFC48354.1 - 0.00014 21.4 0.3 0.00098 18.6 0.3 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC48354.1 - 0.00016 21.4 0.1 0.00034 20.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC48354.1 - 0.0015 19.0 0.0 0.0025 18.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC48354.1 - 0.0024 18.2 0.1 0.0043 17.3 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC48354.1 - 0.0035 17.9 0.0 0.006 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFC48354.1 - 0.0043 16.6 0.0 0.0076 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFC48354.1 - 0.0077 16.7 0.2 0.026 14.9 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 EFC48354.1 - 0.0085 15.7 0.1 0.044 13.4 0.0 2.0 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EFC48354.1 - 0.01 15.0 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 EFC48354.1 - 0.014 15.6 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 EFC48354.1 - 0.015 15.0 0.8 0.054 13.2 0.5 2.2 2 1 1 3 3 3 0 AAA domain NACHT PF05729.12 EFC48354.1 - 0.018 14.9 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_15 PF13175.6 EFC48354.1 - 0.022 14.5 0.1 0.024 14.3 0.1 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 EFC48354.1 - 0.022 15.0 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 EFC48354.1 - 0.03 14.0 0.2 0.056 13.1 0.2 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 EFC48354.1 - 0.036 14.0 0.3 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 NTPase ABC_ATPase PF09818.9 EFC48354.1 - 0.042 12.6 0.0 0.09 11.6 0.0 1.5 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_13 PF13166.6 EFC48354.1 - 0.058 12.0 1.4 0.55 8.8 0.1 2.1 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 EFC48354.1 - 0.07 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.23 EFC48354.1 - 0.12 12.5 0.3 0.22 11.6 0.3 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase NB-ARC PF00931.22 EFC48354.1 - 0.14 11.3 0.2 0.37 10.0 0.1 1.7 1 1 1 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.12 EFC48354.1 - 0.18 11.1 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin EMP24_GP25L PF01105.24 EFC48355.1 - 1.1e-21 77.6 0.3 1.3e-21 77.4 0.3 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TANGO2 PF05742.12 EFC48356.1 - 4.3e-14 53.2 0.0 2.3e-09 37.7 0.0 2.8 2 1 0 2 2 2 2 Transport and Golgi organisation 2 Tnp_22_dsRBD PF17490.2 EFC48356.1 - 0.074 13.1 0.1 0.34 10.9 0.0 2.2 2 1 0 2 2 2 0 L1 transposable element dsRBD-like domain Pkinase PF00069.25 EFC48357.1 - 1.2e-26 93.7 1.7 3.4e-26 92.2 1.7 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48357.1 - 1.7e-15 57.0 0.3 2.6e-15 56.4 0.3 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC48357.1 - 1.1e-06 27.7 0.4 1.7e-06 27.1 0.4 1.2 1 0 0 1 1 1 1 Fungal protein kinase Spuma_A9PTase PF03539.14 EFC48357.1 - 0.0051 17.0 0.1 0.012 15.8 0.0 1.6 2 0 0 2 2 2 1 Spumavirus aspartic protease (A9) APH PF01636.23 EFC48357.1 - 0.026 14.4 0.1 0.047 13.6 0.0 1.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 EFC48357.1 - 0.068 12.5 0.2 0.11 11.8 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CCDC53 PF10152.9 EFC48358.1 - 2.7e-05 24.7 0.0 2.7e-05 24.7 0.0 4.1 4 0 0 4 4 4 1 Subunit CCDC53 of WASH complex FliP PF00813.20 EFC48358.1 - 0.026 14.4 5.5 0.027 14.4 3.6 2.0 1 1 1 2 2 2 0 FliP family SIR2 PF02146.17 EFC48359.1 - 0.053 13.4 0.2 0.095 12.6 0.1 1.5 1 1 0 1 1 1 0 Sir2 family SEO_C PF14577.6 EFC48359.1 - 0.13 11.7 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Sieve element occlusion C-terminus XPG_N PF00752.17 EFC48360.1 - 1.6e-23 83.0 0.0 4.7e-23 81.6 0.0 1.8 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 EFC48360.1 - 4.5e-22 78.2 0.0 2.1e-21 76.1 0.0 2.1 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 EFC48360.1 - 1.3e-05 24.8 0.9 5e-05 22.9 0.1 2.1 1 1 1 2 2 2 1 XPG domain containing 5_3_exonuc PF01367.20 EFC48360.1 - 4.1e-05 24.1 0.0 9e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold TPR_2 PF07719.17 EFC48360.1 - 0.00035 20.5 0.3 0.001 19.0 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat HHH_5 PF14520.6 EFC48360.1 - 0.0022 18.6 0.0 0.0047 17.5 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain TPR_1 PF00515.28 EFC48360.1 - 0.0033 17.2 0.2 0.013 15.3 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat HHH PF00633.23 EFC48360.1 - 0.0037 17.1 0.0 0.0069 16.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif TPR_8 PF13181.6 EFC48360.1 - 0.0039 17.3 0.0 0.014 15.6 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat HemY_N PF07219.13 EFC48360.1 - 0.076 13.2 0.2 0.15 12.2 0.2 1.5 1 0 0 1 1 1 0 HemY protein N-terminus Guanylate_cyc PF00211.20 EFC48361.1 - 1.6e-24 86.5 0.0 3.7e-24 85.4 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC48361.1 - 6.5e-05 22.8 4.9 0.00019 21.3 4.9 1.7 1 1 0 1 1 1 1 Cache domain LisH PF08513.11 EFC48361.1 - 0.12 12.4 0.1 0.25 11.4 0.1 1.5 1 0 0 1 1 1 0 LisH SurA_N_3 PF13624.6 EFC48361.1 - 1.7 8.4 3.6 0.5 10.1 0.2 1.8 2 0 0 2 2 2 0 SurA N-terminal domain Mucin PF01456.17 EFC48362.1 - 0.038 14.0 0.7 0.038 14.0 0.7 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2383 PF09537.10 EFC48362.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) DUF4834 PF16118.5 EFC48362.1 - 0.47 11.5 2.9 6 7.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Macoilin PF09726.9 EFC48362.1 - 0.7 8.4 10.6 0.79 8.2 10.6 1.0 1 0 0 1 1 1 0 Macoilin family DUF4116 PF13475.6 EFC48365.1 - 4.1e-09 36.0 20.2 1.3e-05 24.9 3.2 6.6 5 2 3 8 8 8 4 Domain of unknown function (DUF4116) F-box PF00646.33 EFC48365.1 - 0.13 12.1 0.5 0.55 10.2 0.0 2.4 2 0 0 2 2 2 0 F-box domain Pectate_lyase_3 PF12708.7 EFC48367.1 - 4.4e-11 43.0 9.9 4.4e-11 43.0 9.9 2.7 2 1 0 2 2 2 1 Pectate lyase superfamily protein Beta_helix PF13229.6 EFC48367.1 - 7.8e-07 29.1 56.6 0.73 9.7 50.0 4.0 1 1 1 2 2 2 1 Right handed beta helix region NosD PF05048.13 EFC48367.1 - 0.00098 18.5 47.8 0.043 13.1 13.9 4.3 1 1 3 4 4 4 3 Periplasmic copper-binding protein (NosD) LRR_6 PF13516.6 EFC48368.1 - 6.1e-27 91.4 0.0 3.5e-06 26.6 0.0 6.1 6 0 0 6 6 6 6 Leucine Rich repeat LRR_8 PF13855.6 EFC48368.1 - 1.4e-14 53.6 2.3 5.6e-08 32.4 0.1 2.8 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC48368.1 - 1.3e-13 50.9 6.3 0.00042 20.6 0.1 4.1 1 1 3 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48368.1 - 1.8e-08 33.8 0.0 4.7 8.2 0.0 5.9 6 0 0 6 6 6 1 Leucine Rich Repeat CLU_N PF15044.6 EFC48368.1 - 0.00085 19.6 1.9 1.6 9.2 0.1 3.0 1 1 2 3 3 3 2 Mitochondrial function, CLU-N-term Sialidase PF02973.16 EFC48368.1 - 0.02 14.4 1.7 0.065 12.7 0.4 2.3 1 1 0 2 2 2 0 Sialidase, N-terminal domain DUF4368 PF14287.6 EFC48368.1 - 0.051 13.9 3.9 2.6 8.4 0.1 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4368) DUF3409 PF11889.8 EFC48368.1 - 0.42 10.6 4.5 1 9.3 0.0 3.4 4 1 1 5 5 5 0 Domain of unknown function (DUF3409) UPF0193 PF05250.11 EFC48368.1 - 0.48 10.2 3.5 1.7 8.4 0.2 2.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0193) Vfa1 PF08432.10 EFC48369.1 - 0.41 11.0 13.2 0.89 9.9 13.2 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CFAP91 PF14738.6 EFC48370.1 - 5e-22 78.6 25.3 5e-22 78.6 25.3 4.7 4 1 0 4 4 4 1 Cilia- and flagella-associated protein 91 ubiquitin PF00240.23 EFC48371.1 - 5.5e-16 58.1 2.1 5.5e-16 58.1 2.1 2.1 2 0 0 2 2 2 1 Ubiquitin family Zn_clus PF00172.18 EFC48371.1 - 0.00017 21.6 13.3 0.00034 20.7 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TBK1_ULD PF18396.1 EFC48371.1 - 0.0022 17.9 0.1 0.0066 16.4 0.1 1.9 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain NAC PF01849.18 EFC48372.1 - 5.5e-14 51.9 0.2 5.5e-14 51.9 0.2 1.7 2 0 0 2 2 2 1 NAC domain DUF4629 PF15442.6 EFC48372.1 - 0.48 10.6 5.6 1.1 9.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) PGM_PMM_I PF02878.16 EFC48373.1 - 5.6e-13 48.8 0.0 5.9e-07 29.3 0.0 2.8 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 EFC48373.1 - 1.1e-06 28.7 0.1 3.5e-06 27.1 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 EFC48373.1 - 0.0046 17.6 0.1 0.056 14.1 0.0 2.6 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 EFC48373.1 - 0.0071 16.5 0.1 0.025 14.8 0.1 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Fe-ADH PF00465.19 EFC48374.1 - 2.8e-123 411.4 0.5 3.5e-123 411.0 0.5 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 EFC48374.1 - 8.1e-20 71.6 1.8 1.8e-17 63.9 1.8 2.2 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase ACT_7 PF13840.6 EFC48374.1 - 0.016 15.0 0.1 0.038 13.8 0.1 1.6 1 0 0 1 1 1 0 ACT domain RTC PF01137.21 EFC48375.1 - 6.7e-61 205.3 0.0 1e-60 204.7 0.0 1.3 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Kelch_4 PF13418.6 EFC48376.1 - 1.5e-10 40.9 0.0 2.4e-07 30.6 0.0 3.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC48376.1 - 2.3e-09 37.2 0.0 9.2e-06 25.8 0.0 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_1 PF01344.25 EFC48376.1 - 4.4e-08 32.6 0.3 1.9e-06 27.3 0.0 3.0 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 EFC48376.1 - 1.3e-07 31.5 0.8 1.6e-05 24.8 0.0 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 EFC48376.1 - 3.1e-07 30.5 0.0 0.0016 18.7 0.0 3.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC48376.1 - 0.016 15.2 0.3 0.07 13.1 0.1 2.2 2 0 0 2 2 2 0 Kelch motif TBP-binding PF09247.11 EFC48376.1 - 0.018 15.3 0.3 0.055 13.7 0.3 1.8 1 0 0 1 1 1 0 TATA box-binding protein binding DUF2895 PF11444.8 EFC48376.1 - 0.18 11.1 0.1 0.32 10.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) BTB PF00651.31 EFC48377.1 - 1.5e-18 67.0 1.8 3.9e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain DUF3445 PF11927.8 EFC48377.1 - 0.067 12.8 0.0 0.32 10.6 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3445) DUF2817 PF10994.8 EFC48378.1 - 6.8e-39 134.2 0.1 1.2e-38 133.5 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2817) Aldo_ket_red PF00248.21 EFC48379.1 - 3.2e-77 259.6 0.1 3.6e-77 259.5 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HpuA PF16960.5 EFC48379.1 - 0.11 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter zf-BED PF02892.15 EFC48380.1 - 0.094 12.8 2.3 0.14 12.2 2.3 1.4 1 0 0 1 1 1 0 BED zinc finger CUE PF02845.16 EFC48381.1 - 4.4e-10 39.1 0.0 1.1e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 CUE domain Pribosyltran_N PF13793.6 EFC48382.1 - 4.2e-48 162.1 1.1 1.3e-46 157.3 0.0 2.4 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 EFC48382.1 - 2e-33 115.9 1.0 4.7e-33 114.8 0.9 1.6 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 EFC48382.1 - 1.2e-13 50.9 0.7 1.2e-12 47.6 0.2 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFC48382.1 - 0.0011 18.5 0.1 0.0017 17.8 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DnaJ PF00226.31 EFC48383.1 - 4.6e-25 87.5 2.5 4.6e-25 87.5 2.5 2.6 3 0 0 3 3 3 1 DnaJ domain TAN PF11640.8 EFC48383.1 - 0.7 10.0 8.6 0.8 9.8 5.7 2.4 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair Ras PF00071.22 EFC48384.1 - 1.4e-48 164.5 0.0 1.8e-48 164.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48384.1 - 8.3e-23 80.9 0.0 1.4e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48384.1 - 0.0025 17.3 0.0 0.003 17.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family TMEM131_like PF12371.8 EFC48386.1 - 9.9e-12 45.0 4.0 8.7e-10 38.7 0.1 5.0 6 0 0 6 6 6 1 Transmembrane protein 131-like ASH PF15780.5 EFC48386.1 - 6.7e-06 26.2 5.9 0.044 14.0 0.0 5.6 6 0 0 6 6 6 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TNFR_16_TM PF18422.1 EFC48386.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain RWP-RK PF02042.15 EFC48387.1 - 0.0006 19.7 0.1 0.0012 18.7 0.1 1.5 1 0 0 1 1 1 1 RWP-RK domain Sigma70_r4_2 PF08281.12 EFC48387.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2778 PF10908.8 EFC48387.1 - 0.4 11.0 7.5 0.096 13.0 2.2 2.5 2 2 1 3 3 3 0 Protein of unknown function (DUF2778) Chordopox_A13L PF05961.11 EFC48387.1 - 0.43 10.8 1.6 1.8 8.9 0.1 2.6 2 0 0 2 2 2 0 Chordopoxvirus A13L protein TetR_C_35 PF18556.1 EFC48388.1 - 0.061 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial Tetracyclin repressor, C-terminal domain DUF4735 PF15882.5 EFC48388.1 - 0.092 12.2 7.3 0.028 13.9 1.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4735) MASE4 PF17158.4 EFC48388.1 - 0.097 11.9 1.2 0.22 10.7 0.2 1.9 2 0 0 2 2 2 0 Membrane-associated sensor, integral membrane domain DUF3784 PF12650.7 EFC48388.1 - 0.12 12.6 0.3 0.46 10.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Zip PF02535.22 EFC48388.1 - 0.15 11.2 0.6 0.36 10.0 0.6 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter Complex1_LYR PF05347.15 EFC48388.1 - 0.2 11.7 5.4 0.61 10.2 1.2 3.0 3 0 0 3 3 3 0 Complex 1 protein (LYR family) YtxH PF12732.7 EFC48388.1 - 9.8 6.8 9.9 1.1 9.9 4.3 2.4 2 1 1 3 3 3 0 YtxH-like protein Pkinase PF00069.25 EFC48389.1 - 3.3e-17 62.7 1.6 6.6e-17 61.7 1.6 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48389.1 - 2.2e-10 40.3 0.3 3.7e-10 39.5 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC48389.1 - 0.00038 19.3 3.2 0.00086 18.2 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFC48389.1 - 0.035 14.0 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFC48389.1 - 0.065 12.6 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kelch_4 PF13418.6 EFC48390.1 - 1.7e-16 60.0 0.1 2.7e-06 27.3 0.0 3.4 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC48390.1 - 1.2e-14 54.2 0.0 6.3e-07 29.5 0.0 3.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC48390.1 - 5.7e-10 39.1 1.8 0.0092 16.2 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EFC48390.1 - 4.3e-08 32.8 1.6 0.00026 20.8 0.3 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 EFC48390.1 - 1.8e-07 31.0 3.0 0.09 12.8 0.0 4.0 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 EFC48390.1 - 8.1e-06 25.3 0.9 0.035 13.7 0.2 3.3 3 0 0 3 3 3 2 Kelch motif ISK_Channel PF02060.15 EFC48390.1 - 0.28 10.9 2.5 3.2 7.5 0.2 2.2 2 0 0 2 2 2 0 Slow voltage-gated potassium channel Guanylate_cyc PF00211.20 EFC48391.1 - 4.4e-51 173.1 0.2 8.8e-51 172.1 0.2 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC48391.1 - 2.8e-11 43.4 0.0 9.5e-11 41.7 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 EFC48391.1 - 5.7e-11 42.6 0.1 1.6e-10 41.2 0.1 1.8 1 0 0 1 1 1 1 PAS domain HNOBA PF07701.14 EFC48391.1 - 0.016 14.6 0.3 0.035 13.5 0.3 1.5 1 0 0 1 1 1 0 Heme NO binding associated PAS_8 PF13188.7 EFC48391.1 - 0.03 14.3 0.0 0.088 12.9 0.0 1.8 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 EFC48391.1 - 0.033 14.4 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 PAS fold DUF4116 PF13475.6 EFC48392.1 - 1.1e-105 345.3 17.4 6.9e-17 60.9 0.1 10.9 5 2 9 14 14 14 13 Domain of unknown function (DUF4116) Poty_PP PF08440.10 EFC48392.1 - 0.055 12.5 0.0 0.15 11.2 0.0 1.7 1 0 0 1 1 1 0 Potyviridae polyprotein TF_Zn_Ribbon PF08271.12 EFC48392.1 - 0.086 12.4 1.2 0.34 10.5 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Aminotran_1_2 PF00155.21 EFC48393.1 - 1.6e-45 155.8 0.0 1.9e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 EFC48393.1 - 0.00029 19.5 0.0 0.0006 18.4 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GCR1_C PF12550.8 EFC48393.1 - 0.00039 20.7 0.0 0.0012 19.1 0.0 1.8 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Beta_elim_lyase PF01212.21 EFC48393.1 - 0.0042 16.4 0.0 0.0072 15.6 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase PilS PF08805.11 EFC48393.1 - 0.084 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 PilS N terminal DUF4419 PF14388.6 EFC48394.1 - 1.2e-74 251.5 1.9 2.1e-74 250.7 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4419) HSP70 PF00012.20 EFC48394.1 - 1.7e-09 36.5 0.0 2.7e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein PilM_2 PF11104.8 EFC48394.1 - 0.052 12.6 0.1 0.23 10.5 0.0 2.0 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Pkinase PF00069.25 EFC48395.1 - 1.8e-64 217.6 0.0 3.7e-64 216.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48395.1 - 3e-41 141.4 0.0 6.4e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3543 PF12063.8 EFC48395.1 - 6.1e-05 22.5 0.5 0.00043 19.7 0.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3543) MIT PF04212.18 EFC48395.1 - 0.00019 21.4 0.4 0.63 10.2 0.0 2.5 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Pkinase_fungal PF17667.1 EFC48395.1 - 0.018 13.9 0.7 0.051 12.4 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 EFC48395.1 - 0.22 11.0 3.3 0.92 9.0 0.1 2.8 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL SPO22 PF08631.10 EFC48396.1 - 3.8e-41 141.4 22.0 2.8e-37 128.7 3.9 3.4 3 0 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 EFC48396.1 - 4.2e-11 43.0 4.4 7.1e-05 23.0 0.2 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48396.1 - 2.6e-06 27.1 17.2 0.043 13.9 0.1 7.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48396.1 - 1.7e-05 25.2 7.5 0.0066 16.9 0.1 5.5 5 1 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC48396.1 - 0.00067 19.8 2.0 0.00067 19.8 2.0 3.8 3 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 UPF0697 PF15117.6 EFC48396.1 - 0.016 15.2 0.3 0.094 12.8 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0697 TPR_MalT PF17874.1 EFC48396.1 - 0.017 14.5 3.6 2.8 7.2 0.1 3.1 3 0 0 3 3 3 0 MalT-like TPR region TPR_1 PF00515.28 EFC48396.1 - 0.066 13.1 0.0 0.066 13.1 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48396.1 - 0.13 13.1 1.4 14 6.8 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC48396.1 - 0.34 10.9 4.5 5 7.2 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat ERGIC_N PF13850.6 EFC48397.1 - 5.4 7.4 7.0 12 6.3 0.1 3.6 3 1 1 4 4 4 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) AAA PF00004.29 EFC48398.1 - 8.2e-16 58.6 0.0 1.2e-15 58.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFC48398.1 - 9.8e-05 22.4 0.0 0.00037 20.5 0.0 2.0 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFC48398.1 - 0.00054 19.2 0.0 0.00063 19.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EFC48398.1 - 0.0014 19.0 0.0 0.0024 18.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFC48398.1 - 0.02 14.7 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC48398.1 - 0.034 13.9 0.1 0.09 12.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EFC48398.1 - 0.051 13.2 0.0 0.082 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 EFC48398.1 - 0.072 13.0 0.1 0.48 10.3 0.1 2.0 1 1 1 2 2 2 0 NACHT domain AAA_18 PF13238.6 EFC48398.1 - 0.087 13.4 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC48398.1 - 0.17 12.1 0.0 0.28 11.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain HATPase_c PF02518.26 EFC48399.1 - 9.9e-23 80.8 0.2 2.7e-22 79.4 0.2 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC48399.1 - 7.6e-18 64.7 0.5 2e-17 63.4 0.5 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC48399.1 - 2.7e-10 40.1 0.8 7e-10 38.8 0.2 2.0 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 EFC48399.1 - 7.8e-05 22.5 0.2 0.0018 18.2 0.0 2.7 2 0 0 2 2 2 1 GHKL domain HATPase_c_3 PF13589.6 EFC48399.1 - 0.0011 18.8 0.0 0.0038 17.1 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Staph_haemo PF05480.11 EFC48399.1 - 0.064 13.0 0.2 0.21 11.4 0.2 1.8 1 0 0 1 1 1 0 Staphylococcus haemolytic protein YqaH PF17448.2 EFC48399.1 - 0.086 13.1 0.4 0.52 10.7 0.1 2.5 3 0 0 3 3 3 0 Uncharacterized YqaH-like Orf78 PF06024.12 EFC48399.1 - 0.087 13.1 0.8 0.38 11.1 0.8 2.1 1 0 0 1 1 1 0 Orf78 (ac78) 2-Hacid_dh_C PF02826.19 EFC48400.1 - 8.9e-58 194.6 0.0 1.2e-57 194.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 EFC48400.1 - 1.3e-11 44.3 0.0 1.7e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 EFC48400.1 - 4.6e-06 26.9 0.4 7.4e-06 26.2 0.1 1.4 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 EFC48400.1 - 0.00037 20.1 0.3 0.0007 19.2 0.1 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 EFC48400.1 - 0.0084 16.0 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFC48400.1 - 0.0093 16.5 0.0 0.022 15.3 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 EFC48400.1 - 0.022 14.8 0.5 0.067 13.3 0.5 1.8 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 EFC48400.1 - 0.034 14.6 0.0 0.072 13.5 0.0 1.6 1 1 0 1 1 1 0 Putative NAD(P)-binding Fungal_trans PF04082.18 EFC48401.1 - 0.046 12.8 0.6 0.07 12.2 0.6 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF4579 PF15158.6 EFC48401.1 - 3.8 7.2 7.4 14 5.4 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4579) p450 PF00067.22 EFC48402.1 - 3.9e-59 200.6 0.3 5e-59 200.3 0.3 1.1 1 0 0 1 1 1 1 Cytochrome P450 Ubiq_cyt_C_chap PF03981.12 EFC48402.1 - 0.094 12.8 0.0 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Ubiquinol-cytochrome C chaperone MTTB PF06253.11 EFC48402.1 - 0.15 10.0 0.0 0.24 9.4 0.0 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) DUF4116 PF13475.6 EFC48403.1 - 1.9e-07 30.7 4.2 1.5e-05 24.6 1.3 3.2 3 1 1 4 4 4 2 Domain of unknown function (DUF4116) RPW8 PF05659.11 EFC48403.1 - 0.16 11.6 1.5 0.42 10.3 0.7 2.1 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 GIT_CC PF16559.5 EFC48404.1 - 0.0025 17.6 8.0 0.34 10.8 1.2 3.6 3 0 0 3 3 3 2 GIT coiled-coil Rho guanine nucleotide exchange factor SHE3 PF17078.5 EFC48404.1 - 0.0033 17.2 9.8 0.0033 17.2 9.8 1.8 2 0 0 2 2 1 1 SWI5-dependent HO expression protein 3 TMCO5 PF14992.6 EFC48404.1 - 0.0037 16.9 12.2 0.0059 16.2 12.2 1.3 1 0 0 1 1 1 1 TMCO5 family GAS PF13851.6 EFC48404.1 - 0.0081 15.5 9.4 0.017 14.5 9.4 1.5 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 EFC48404.1 - 0.013 14.4 8.3 0.023 13.6 8.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein ACCA PF03255.14 EFC48404.1 - 0.015 15.1 2.2 0.93 9.4 0.2 2.8 3 0 0 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit TPR_MLP1_2 PF07926.12 EFC48404.1 - 0.019 15.0 10.8 0.038 14.0 10.8 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 EFC48404.1 - 0.021 14.1 0.9 0.021 14.1 0.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 EFC48404.1 - 0.055 12.8 1.8 0.085 12.2 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Filament PF00038.21 EFC48404.1 - 0.13 11.8 8.5 0.35 10.4 8.0 1.8 1 1 0 1 1 1 0 Intermediate filament protein DUF1664 PF07889.12 EFC48404.1 - 0.15 12.1 9.5 2.6 8.1 0.5 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 EFC48404.1 - 0.15 12.2 9.6 0.091 12.9 1.8 3.3 3 0 0 3 3 2 0 JNK-interacting protein leucine zipper II Jnk-SapK_ap_N PF09744.9 EFC48404.1 - 0.16 12.2 9.5 0.99 9.6 3.2 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.12 EFC48404.1 - 0.2 11.7 17.1 0.8 9.7 7.8 2.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CLZ PF16526.5 EFC48404.1 - 0.28 11.5 5.0 8.7 6.8 0.8 3.3 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TMF_TATA_bd PF12325.8 EFC48404.1 - 0.34 11.1 8.5 0.071 13.3 2.7 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Ribosomal_L6e PF01159.19 EFC48404.1 - 0.56 10.8 3.7 0.78 10.3 2.0 2.1 1 1 1 2 2 2 0 Ribosomal protein L6e FlaC_arch PF05377.11 EFC48404.1 - 0.56 10.6 10.3 9.5 6.7 0.9 4.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Cnn_1N PF07989.11 EFC48404.1 - 0.57 10.4 8.0 8.3 6.6 7.9 2.7 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 ZapB PF06005.12 EFC48404.1 - 0.75 10.3 7.3 1.4e+02 3.0 7.3 2.9 1 1 0 1 1 1 0 Cell division protein ZapB DUF16 PF01519.16 EFC48404.1 - 0.94 10.0 11.3 11 6.6 4.8 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 Snapin_Pallidin PF14712.6 EFC48404.1 - 1.4 9.4 11.4 2.3 8.7 3.6 3.5 2 1 1 3 3 3 0 Snapin/Pallidin DivIC PF04977.15 EFC48404.1 - 1.4 8.7 7.0 3.6 7.4 0.8 3.4 1 1 2 3 3 3 0 Septum formation initiator CdvA PF18822.1 EFC48404.1 - 1.8 8.4 8.8 27 4.6 8.3 2.8 1 1 1 2 2 2 0 CdvA-like coiled-coil domain YabA PF06156.13 EFC48404.1 - 2 9.1 11.2 3.1 8.5 3.0 2.6 1 1 1 2 2 2 0 Initiation control protein YabA Ax_dynein_light PF10211.9 EFC48404.1 - 2.1 8.3 9.6 1.4 8.9 1.9 2.4 1 1 1 2 2 2 0 Axonemal dynein light chain DASH_Dam1 PF08653.10 EFC48404.1 - 2.2 8.1 9.4 6.8 6.6 0.2 4.3 3 1 0 4 4 3 0 DASH complex subunit Dam1 Fungal_TACC PF12709.7 EFC48404.1 - 2.7 8.5 9.7 0.29 11.6 0.6 3.0 3 1 0 3 3 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins APG6_N PF17675.1 EFC48404.1 - 3.1 8.3 9.1 6 7.4 1.9 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF2935 PF11155.8 EFC48404.1 - 3.5 8.0 6.5 23 5.4 1.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DUF4200 PF13863.6 EFC48404.1 - 3.5 8.0 7.8 27 5.2 2.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ATG16 PF08614.11 EFC48404.1 - 3.6 7.8 10.5 10 6.3 10.5 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 EFC48404.1 - 3.8 7.7 12.9 2.6 8.2 3.1 3.6 3 0 0 3 3 3 0 bZIP transcription factor DUF948 PF06103.11 EFC48404.1 - 3.9 7.8 8.9 11 6.4 1.6 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LPP PF04728.13 EFC48404.1 - 4.2 7.8 9.4 0.93 9.9 0.5 3.5 2 1 1 3 3 3 0 Lipoprotein leucine-zipper BRE1 PF08647.11 EFC48404.1 - 8 6.6 11.8 2.5 8.2 4.6 2.9 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Tropomyosin_1 PF12718.7 EFC48404.1 - 8.8 6.5 10.5 19 5.4 10.5 1.5 1 0 0 1 1 1 0 Tropomyosin like Peptidase_M24 PF00557.24 EFC48405.1 - 2.3e-39 135.3 0.1 3.3e-39 134.8 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF5453 PF17534.2 EFC48406.1 - 3 7.7 18.1 0.036 14.0 1.8 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5453) Nipped-B_C PF12830.7 EFC48407.1 - 0.042 13.8 0.3 0.15 12.0 0.2 1.9 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus ER PF01133.17 EFC48407.1 - 0.052 13.6 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Enhancer of rudimentary F-box PF00646.33 EFC48408.1 - 0.082 12.8 1.1 0.23 11.4 1.1 1.8 1 0 0 1 1 1 0 F-box domain TRP PF06011.12 EFC48409.1 - 0.045 12.5 0.0 0.059 12.1 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel Rota_Capsid_VP6 PF00980.17 EFC48409.1 - 0.065 12.1 0.2 0.085 11.8 0.2 1.1 1 0 0 1 1 1 0 Rotavirus major capsid protein VP6 Rhodanese PF00581.20 EFC48410.1 - 5.7e-09 36.5 0.0 9.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain UQ_con PF00179.26 EFC48411.1 - 9.8e-23 80.3 0.5 1.1e-22 80.2 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC48411.1 - 0.14 12.4 1.0 0.16 12.2 1.0 1.2 1 1 0 1 1 1 0 RWD domain ECSCR PF15820.5 EFC48413.1 - 0.036 13.9 0.2 0.069 13.0 0.2 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator zf-HIT PF04438.16 EFC48414.1 - 0.0029 17.5 2.5 0.0029 17.5 2.5 3.3 3 0 0 3 3 3 1 HIT zinc finger zf-B_box PF00643.24 EFC48414.1 - 0.0043 17.2 17.0 0.0043 17.2 17.0 3.5 4 1 0 4 4 4 1 B-box zinc finger PAP_RNA-bind PF04926.15 EFC48414.1 - 0.046 13.3 0.1 0.13 11.9 0.1 1.8 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain DUF3342 PF11822.8 EFC48414.1 - 0.37 11.0 5.8 0.61 10.3 0.9 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) Ephrin_rec_like PF07699.13 EFC48414.1 - 1.2 8.9 11.6 0.042 13.6 3.3 2.5 2 0 0 2 2 2 0 Putative ephrin-receptor like zf-piccolo PF05715.13 EFC48414.1 - 1.8 8.8 12.5 0.22 11.7 4.4 2.7 2 0 0 2 2 2 0 Piccolo Zn-finger Cortex-I_coil PF09304.10 EFC48414.1 - 5.5 7.3 13.9 0.54 10.5 0.7 2.5 1 1 0 2 2 2 0 Cortexillin I, coiled coil DUF641 PF04859.12 EFC48416.1 - 0.026 14.8 6.0 0.037 14.4 5.4 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) TSC22 PF01166.18 EFC48416.1 - 0.028 14.7 1.3 0.08 13.3 1.2 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family ABC_tran_CTD PF16326.5 EFC48416.1 - 0.057 13.7 3.1 0.11 12.8 3.1 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain DUF2524 PF10732.9 EFC48416.1 - 0.1 12.9 3.0 15 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) PKcGMP_CC PF16808.5 EFC48416.1 - 0.16 11.8 2.6 3.7 7.5 0.1 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4064 PF13273.6 EFC48417.1 - 0.0077 16.5 2.5 0.014 15.7 2.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4064) Stevor PF17410.2 EFC48417.1 - 0.033 13.7 1.3 0.04 13.5 1.3 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame MFS_1 PF07690.16 EFC48418.1 - 7.9e-34 117.1 63.7 1.2e-25 90.3 26.3 2.9 1 1 2 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 EFC48418.1 - 6.3e-08 31.6 27.8 0.0001 21.0 7.2 3.2 3 1 0 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.24 EFC48418.1 - 1.5e-05 24.1 31.3 0.0001 21.3 8.4 3.0 2 1 0 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 EFC48418.1 - 0.0034 16.3 20.2 0.01 14.7 20.1 2.2 1 1 0 1 1 1 1 MFS_1 like family SieB PF14163.6 EFC48418.1 - 3 7.3 6.3 2.4 7.7 0.1 3.1 3 1 0 3 3 3 0 Super-infection exclusion protein B Phage_holin_1 PF04531.13 EFC48418.1 - 3.3 8.3 7.3 2.6 8.6 0.2 3.3 2 1 0 2 2 2 0 Bacteriophage holin zf-AN1 PF01428.16 EFC48421.1 - 0.019 15.1 6.4 0.84 9.9 1.2 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger Elf1 PF05129.13 EFC48421.1 - 0.08 13.0 1.7 11 6.2 0.1 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like C1_1 PF00130.22 EFC48421.1 - 0.13 12.2 5.0 1.9 8.5 0.4 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C2H2_4 PF13894.6 EFC48421.1 - 0.67 11.0 8.2 6.5 7.9 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zinc_ribbon_5 PF13719.6 EFC48421.1 - 0.76 9.6 6.5 7.3 6.4 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-H2C2_2 PF13465.6 EFC48421.1 - 7.7 7.1 11.7 5.3 7.6 0.9 3.1 3 0 0 3 3 3 0 Zinc-finger double domain FAD_binding_3 PF01494.19 EFC48422.1 - 6.2e-08 32.3 0.0 1.3e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC48422.1 - 3.1e-05 23.4 0.1 0.013 14.8 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 EFC48422.1 - 9.2e-05 22.9 0.3 0.0012 19.4 0.0 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC48422.1 - 0.00013 21.7 0.1 0.043 13.4 0.1 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFC48422.1 - 0.02 13.6 0.0 0.51 9.0 0.0 2.4 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 EFC48422.1 - 0.072 11.9 0.0 3.6 6.3 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_2 PF00890.24 EFC48422.1 - 0.079 12.0 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 EFC48422.1 - 0.11 11.8 0.0 0.5 9.7 0.0 1.9 1 1 0 1 1 1 0 FAD dependent oxidoreductase Ras PF00071.22 EFC48423.1 - 3.9e-20 72.1 0.0 6.1e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48423.1 - 6.1e-16 58.7 0.0 1e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48423.1 - 0.00035 20.1 0.0 0.0013 18.2 0.0 1.7 1 1 1 2 2 2 1 ADP-ribosylation factor family AAA_18 PF13238.6 EFC48423.1 - 0.023 15.2 0.0 0.066 13.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain Peptidase_S8 PF00082.22 EFC48424.1 - 1e-39 136.6 7.1 2.3e-39 135.5 7.1 1.5 1 0 0 1 1 1 1 Subtilase family DUF4468 PF14730.6 EFC48424.1 - 1.4 9.2 10.3 0.052 13.9 2.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4468) with TBP-like fold Peptidase_S8 PF00082.22 EFC48425.1 - 6.6e-36 124.1 11.4 1.9e-35 122.5 11.4 1.7 1 1 0 1 1 1 1 Subtilase family BTB_2 PF02214.22 EFC48425.1 - 2.2e-14 53.6 2.2 4.6e-08 33.3 0.1 3.6 2 1 0 2 2 2 2 BTB/POZ domain IKKbetaNEMObind PF12179.8 EFC48425.1 - 0.028 14.4 0.2 0.11 12.5 0.2 2.1 1 0 0 1 1 1 0 I-kappa-kinase-beta NEMO binding domain Y_Y_Y PF07495.13 EFC48425.1 - 0.073 13.0 0.1 0.28 11.2 0.1 2.0 1 0 0 1 1 1 0 Y_Y_Y domain MgtE_N PF03448.17 EFC48425.1 - 0.09 13.4 0.0 0.3 11.7 0.0 1.9 1 0 0 1 1 1 0 MgtE intracellular N domain Sugar_tr PF00083.24 EFC48426.1 - 2.1e-54 185.1 36.8 3.5e-54 184.4 36.8 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 EFC48426.1 - 5.8e-23 81.4 32.3 7.5e-17 61.3 16.7 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily PDEase_II PF02112.15 EFC48426.1 - 0.14 11.2 3.6 0.23 10.5 3.6 1.2 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II CH PF00307.31 EFC48426.1 - 0.18 12.0 1.0 0.88 9.8 0.7 2.2 2 0 0 2 2 2 0 Calponin homology (CH) domain LRR_6 PF13516.6 EFC48427.1 - 6.5e-21 72.6 27.0 0.0078 16.2 0.1 8.5 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.7 EFC48427.1 - 2.2e-07 31.1 27.4 0.0037 17.6 2.7 5.6 2 2 2 6 6 6 5 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC48427.1 - 1.3e-05 25.0 4.0 1.9e-05 24.5 0.2 2.6 3 0 0 3 3 3 1 F-box-like LRR_1 PF00560.33 EFC48427.1 - 0.001 19.3 31.2 9.3 7.2 0.4 8.5 7 2 1 8 8 8 3 Leucine Rich Repeat F-box PF00646.33 EFC48427.1 - 0.047 13.6 0.2 0.047 13.6 0.2 4.1 4 0 0 4 4 4 0 F-box domain LRR_8 PF13855.6 EFC48427.1 - 2.2 8.1 24.0 11 5.8 0.1 5.5 4 2 1 5 5 5 0 Leucine rich repeat NHL PF01436.21 EFC48428.1 - 1e-31 107.3 8.0 0.00097 19.1 0.1 13.1 14 0 0 14 14 14 5 NHL repeat RGS PF00615.19 EFC48428.1 - 6.6e-08 32.8 2.9 6.6e-08 32.8 2.9 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain SGL PF08450.12 EFC48428.1 - 6e-07 29.3 2.9 0.63 9.6 0.0 5.7 5 1 1 6 6 6 2 SMP-30/Gluconolactonase/LRE-like region GPS PF01825.21 EFC48428.1 - 1.2e-06 28.9 6.8 2.8e-06 27.8 6.8 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PQQ_3 PF13570.6 EFC48428.1 - 0.29 11.7 2.1 17 6.1 0.1 4.6 5 0 0 5 5 5 0 PQQ-like domain EGF PF00008.27 EFC48428.1 - 0.86 10.0 4.3 2.5 8.5 4.3 1.8 1 0 0 1 1 1 0 EGF-like domain P21-Arc PF04062.14 EFC48429.1 - 1.4e-59 201.1 0.9 1.5e-59 200.9 0.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hydantoinase_B PF02538.14 EFC48430.1 - 6.4e-194 645.1 0.1 8.1e-194 644.8 0.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 EFC48430.1 - 1.3e-95 320.0 0.1 2.7e-95 319.0 0.0 1.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 EFC48430.1 - 7.6e-57 191.9 4.6 7e-55 185.5 0.0 3.0 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase N-terminal region Proteasome_A_N PF10584.9 EFC48430.1 - 0.17 11.6 0.4 0.64 9.7 0.0 2.2 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature BTB PF00651.31 EFC48431.1 - 5.7e-12 45.8 3.5 3e-11 43.5 0.5 2.9 3 0 0 3 3 3 1 BTB/POZ domain Ank_5 PF13857.6 EFC48431.1 - 7.7e-07 29.3 0.0 2.2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC48431.1 - 9.9e-07 29.2 0.0 3.1e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC48431.1 - 2.4e-06 28.0 0.0 7e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC48431.1 - 0.00014 22.2 0.0 0.00033 21.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 EFC48431.1 - 0.00023 21.3 0.0 0.00095 19.5 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat PCRF PF03462.18 EFC48431.1 - 0.023 14.5 3.0 0.49 10.2 0.6 2.6 2 0 0 2 2 2 0 PCRF domain DUF3342 PF11822.8 EFC48431.1 - 0.11 12.8 1.6 0.38 11.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) DUF2207 PF09972.9 EFC48432.1 - 0.97 8.1 7.3 2 7.1 7.3 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Ycf66_N PF07444.11 EFC48432.1 - 2.1 8.5 10.4 1.2 9.4 0.5 2.3 2 0 0 2 2 2 0 Ycf66 protein N-terminus DUF4116 PF13475.6 EFC48433.1 - 1.2e-138 450.7 46.8 1.2e-15 57.0 0.0 11.6 1 1 15 16 16 16 16 Domain of unknown function (DUF4116) DUF5033 PF16436.5 EFC48433.1 - 0.00082 19.4 0.5 0.55 10.2 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF5033) 6PF2K PF01591.18 EFC48433.1 - 0.019 14.2 5.8 0.092 12.0 0.4 3.6 2 2 2 4 4 4 0 6-phosphofructo-2-kinase CBM60 PF16841.5 EFC48433.1 - 0.052 14.0 0.0 31 5.1 0.0 4.6 5 0 0 5 5 5 0 Ca-dependent carbohydrate-binding module xylan-binding PUA_2 PF14306.6 EFC48433.1 - 0.11 12.1 0.3 0.62 9.7 0.1 2.1 2 0 0 2 2 2 0 PUA-like domain Rotamase PF00639.21 EFC48434.1 - 5.7e-22 78.5 0.0 8.6e-22 77.9 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 EFC48434.1 - 3.9e-21 75.8 0.7 6.4e-21 75.1 0.5 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 EFC48434.1 - 1.4e-12 47.5 2.9 2.4e-12 46.7 1.5 2.0 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 EFC48434.1 - 0.0029 18.5 0.0 0.005 17.7 0.0 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain X8 PF07983.13 EFC48434.1 - 0.079 13.7 0.0 0.16 12.6 0.0 1.5 1 0 0 1 1 1 0 X8 domain CBS PF00571.28 EFC48435.1 - 6.2e-12 45.8 0.2 1.2e-07 32.0 0.1 2.1 2 0 0 2 2 2 2 CBS domain MLD PF11647.8 EFC48436.1 - 0.066 13.5 0.3 8 6.8 0.0 4.3 4 1 1 5 5 5 0 Membrane Localization Domain TBCC_N PF16752.5 EFC48436.1 - 1.4 9.3 17.4 1.2 9.6 1.1 4.3 4 1 0 5 5 5 0 Tubulin-specific chaperone C N-terminal domain DUF2157 PF09925.9 EFC48437.1 - 1.5 8.6 8.4 1.5 8.6 6.4 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) pXO2-34 PF17362.2 EFC48438.1 - 0.052 13.4 0.1 0.38 10.7 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function GIY-YIG PF01541.24 EFC48438.1 - 0.06 13.6 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 GIY-YIG catalytic domain Protamine_P2 PF00841.19 EFC48440.1 - 0.1 13.1 16.1 0.16 12.5 16.1 1.3 1 0 0 1 1 1 0 Sperm histone P2 O-antigen_lig PF13425.6 EFC48440.1 - 0.88 8.3 4.0 0.95 8.2 4.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein ETC_C1_NDUFA5 PF04716.14 EFC48442.1 - 0.00024 20.9 0.0 0.00037 20.2 0.0 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region Ras PF00071.22 EFC48443.1 - 2.5e-54 183.2 0.4 2.8e-54 183.1 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48443.1 - 1e-31 109.6 0.2 1.3e-31 109.3 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48443.1 - 1.5e-15 57.1 0.6 1.6e-15 57.0 0.6 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC48443.1 - 1.4e-06 27.8 0.4 2.4e-06 27.1 0.4 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC48443.1 - 2e-06 27.5 0.4 4.1e-05 23.2 0.1 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC48443.1 - 2.5e-06 27.1 0.1 2.7e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 EFC48443.1 - 2e-05 24.6 0.2 3e-05 24.1 0.2 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC48443.1 - 0.0034 17.3 0.8 0.21 11.5 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 EFC48443.1 - 0.011 15.3 0.2 0.021 14.4 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EFC48443.1 - 0.014 15.4 0.2 0.027 14.5 0.1 1.5 1 1 0 1 1 1 0 C-terminal region of MMR_HSR1 domain TniB PF05621.11 EFC48443.1 - 0.031 13.7 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein adh_short PF00106.25 EFC48443.1 - 0.064 12.7 0.0 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 short chain dehydrogenase PduV-EutP PF10662.9 EFC48443.1 - 0.19 11.5 0.8 0.64 9.8 0.8 2.0 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Synaptobrevin PF00957.21 EFC48444.1 - 9.5e-18 63.8 4.2 2.5e-17 62.4 4.2 1.7 1 0 0 1 1 1 1 Synaptobrevin DUF848 PF05852.11 EFC48444.1 - 0.0019 18.3 1.8 0.0032 17.6 1.8 1.3 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) Dehydratase_SU PF02287.15 EFC48444.1 - 0.027 14.5 0.6 0.063 13.4 0.5 1.7 1 1 0 1 1 1 0 Dehydratase small subunit Longin PF13774.6 EFC48444.1 - 0.089 12.8 0.2 0.23 11.5 0.1 1.7 2 0 0 2 2 2 0 Regulated-SNARE-like domain DUF3430 PF11912.8 EFC48446.1 - 0.0068 16.5 27.3 0.1 12.6 11.0 3.0 1 1 2 3 3 3 2 Protein of unknown function (DUF3430) DUF4841 PF16129.5 EFC48446.1 - 0.21 11.8 3.8 34 4.8 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4841) SDA1 PF05285.12 EFC48448.1 - 5.4e-39 134.6 36.3 5.4e-39 134.6 36.3 2.9 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 EFC48448.1 - 2.3e-10 40.6 0.2 7e-10 39.1 0.2 1.9 1 0 0 1 1 1 1 NUC130/3NT domain Pkinase PF00069.25 EFC48449.1 - 9.7e-45 153.0 1.9 2.5e-44 151.6 1.9 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48449.1 - 3.1e-33 115.1 0.3 6e-33 114.2 0.3 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase adh_short PF00106.25 EFC48449.1 - 2.6e-29 102.1 0.0 7.8e-29 100.5 0.0 1.8 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC48449.1 - 4.9e-13 49.2 0.0 1.7e-12 47.4 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC48449.1 - 2.6e-08 34.0 0.4 1.1e-07 31.9 0.0 2.1 2 0 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 EFC48449.1 - 3.2e-05 23.5 0.0 6.9e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 EFC48449.1 - 0.00016 20.8 0.1 0.00066 18.8 0.1 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC48449.1 - 0.00024 20.7 0.0 0.00084 18.9 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pkinase_fungal PF17667.1 EFC48449.1 - 0.00034 19.5 0.1 0.00061 18.7 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Sacchrp_dh_NADP PF03435.18 EFC48449.1 - 0.00044 20.5 0.0 0.0015 18.8 0.0 1.9 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 EFC48449.1 - 0.00045 19.4 0.1 0.0012 18.1 0.1 1.7 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Kdo PF06293.14 EFC48449.1 - 0.0074 15.7 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 EFC48449.1 - 0.0091 16.2 0.0 0.037 14.2 0.0 2.1 1 0 0 1 1 1 1 ABC1 family Ank_5 PF13857.6 EFC48449.1 - 0.057 13.8 0.0 16 5.9 0.0 3.0 1 1 1 2 2 2 0 Ankyrin repeats (many copies) NAD_binding_10 PF13460.6 EFC48449.1 - 0.22 11.4 0.0 0.49 10.3 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding TauD PF02668.16 EFC48450.1 - 3.6e-11 43.4 0.0 2.8e-05 24.0 0.1 2.9 2 1 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family MIG-14_Wnt-bd PF06664.12 EFC48451.1 - 7.2e-86 288.0 40.3 7.2e-86 288.0 40.3 1.7 2 0 0 2 2 2 1 Wnt-binding factor required for Wnt secretion DUF3675 PF12428.8 EFC48451.1 - 0.033 14.8 0.3 0.12 12.9 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3675) HSP70 PF00012.20 EFC48452.1 - 8.7e-260 863.0 7.1 1e-259 862.8 7.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 EFC48452.1 - 1.2e-14 53.9 4.7 1.1e-12 47.5 0.1 3.0 3 1 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.16 EFC48452.1 - 0.0004 20.2 0.0 0.0013 18.5 0.0 1.9 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 EFC48452.1 - 0.0053 17.2 4.4 4.2 7.8 0.0 4.2 3 2 0 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.20 EFC48452.1 - 0.025 14.1 0.1 1.7 8.0 0.1 2.6 2 1 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 EFC48452.1 - 0.16 11.2 10.6 2.9 7.1 0.1 4.1 5 0 0 5 5 5 0 Hydantoinase/oxoprolinase PIEZO PF15917.5 EFC48452.1 - 1.5 8.2 8.2 2.8 7.4 8.2 1.5 1 0 0 1 1 1 0 Piezo ATP-synt_B PF00430.18 EFC48452.1 - 5.9 7.0 15.1 18 5.4 15.1 1.9 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) XPG_N PF00752.17 EFC48453.1 - 1.5e-30 105.6 0.0 3.9e-30 104.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 EFC48453.1 - 7.8e-29 99.9 0.0 2.2e-28 98.4 0.0 1.8 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 EFC48453.1 - 2.1e-07 31.5 0.0 5.2e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 EFC48453.1 - 0.0067 17.0 0.0 0.016 15.8 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain 5_3_exonuc_N PF02739.16 EFC48453.1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.6 1 1 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain FeThRed_A PF02941.15 EFC48453.1 - 0.096 12.8 0.0 0.37 11.0 0.0 1.9 2 0 0 2 2 2 0 Ferredoxin thioredoxin reductase variable alpha chain HHH_2 PF12826.7 EFC48453.1 - 0.13 12.4 0.0 0.37 10.9 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif LRR_6 PF13516.6 EFC48455.1 - 2.7e-14 51.9 48.2 0.00013 21.7 0.1 11.9 12 1 1 13 13 13 6 Leucine Rich repeat LRR_4 PF12799.7 EFC48455.1 - 6.4e-09 36.0 54.0 0.0032 17.8 4.0 10.7 3 2 10 13 13 13 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC48455.1 - 8e-07 28.7 41.6 0.0013 18.4 3.4 7.3 5 2 2 7 7 7 3 Leucine rich repeat LRR_1 PF00560.33 EFC48455.1 - 0.0013 19.0 35.0 5.3 8.0 1.0 11.3 11 2 0 11 11 11 2 Leucine Rich Repeat WD40 PF00400.32 EFC48456.1 - 2.8e-16 59.6 1.7 3.8e-07 30.7 0.4 4.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48456.1 - 0.00014 22.1 0.3 0.24 11.7 0.0 4.6 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Macoilin PF09726.9 EFC48458.1 - 0.22 10.0 7.9 0.27 9.8 7.9 1.1 1 0 0 1 1 1 0 Macoilin family CDP-OH_P_transf PF01066.21 EFC48459.1 - 1.7e-15 57.5 0.1 1.7e-15 57.5 0.1 3.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Viral_Beta_CD PF04530.12 EFC48459.1 - 0.15 12.4 0.2 0.15 12.4 0.2 3.4 3 1 1 4 4 4 0 Viral Beta C/D like family VirB3 PF05101.13 EFC48459.1 - 0.39 11.0 0.0 0.39 11.0 0.0 4.0 5 1 0 5 5 5 0 Type IV secretory pathway, VirB3-like protein GCK PF07802.11 EFC48460.1 - 0.059 13.8 1.6 0.073 13.5 0.7 1.6 2 0 0 2 2 2 0 GCK domain DUF4096 PF13340.6 EFC48460.1 - 0.25 11.6 2.6 0.48 10.7 1.5 1.9 1 1 1 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) adh_short PF00106.25 EFC48461.1 - 1.7e-24 86.4 0.0 1.8e-23 83.0 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC48461.1 - 1.7e-11 44.1 0.0 2.3e-10 40.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC48461.1 - 5.3e-07 29.7 0.0 8.3e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF2153 PF09921.9 EFC48461.1 - 0.13 12.1 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) CSTF2_hinge PF14327.6 EFC48462.1 - 0.11 12.9 0.1 0.3 11.6 0.1 1.7 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 Kelch_4 PF13418.6 EFC48463.1 - 8.4e-25 86.5 7.2 4.6e-08 33.0 0.0 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC48463.1 - 1.3e-24 85.9 11.7 1.5e-11 44.3 0.3 5.0 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC48463.1 - 7.5e-18 63.8 6.2 7.1e-06 25.5 0.1 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFC48463.1 - 1.4e-16 59.8 6.0 6.4e-06 25.9 0.1 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 EFC48463.1 - 3.5e-16 58.9 14.5 5.1e-07 29.8 0.1 4.5 3 1 2 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EFC48463.1 - 8e-12 44.9 6.6 6e-05 22.9 0.0 4.3 4 0 0 4 4 4 2 Kelch motif F-box-like PF12937.7 EFC48464.1 - 0.002 17.9 0.2 0.0048 16.8 0.2 1.6 1 0 0 1 1 1 1 F-box-like Pkinase PF00069.25 EFC48465.1 - 2.6e-69 233.5 0.0 5.7e-69 232.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48465.1 - 5.8e-34 117.5 0.0 1.1e-33 116.7 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase PH PF00169.29 EFC48465.1 - 4.4e-17 62.5 0.2 8.3e-17 61.6 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFC48465.1 - 9.5e-07 29.0 0.4 9.5e-07 29.0 0.4 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Kinase-like PF14531.6 EFC48465.1 - 0.00016 21.1 0.0 0.00053 19.4 0.0 1.9 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 EFC48465.1 - 0.0021 17.7 0.1 0.52 9.9 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 EFC48465.1 - 0.0084 14.9 0.0 0.013 14.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase PH_11 PF15413.6 EFC48465.1 - 0.015 15.7 5.5 0.078 13.4 5.5 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 EFC48465.1 - 0.02 14.7 0.5 0.18 11.6 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain SNARE_assoc PF09335.11 EFC48466.1 - 6.7e-11 42.7 8.0 9.1e-11 42.3 8.0 1.2 1 0 0 1 1 1 1 SNARE associated Golgi protein Sm_multidrug_ex PF06695.11 EFC48466.1 - 0.061 14.0 3.5 0.098 13.3 3.5 1.3 1 0 0 1 1 1 0 Putative small multi-drug export protein Cas_Cas4 PF01930.17 EFC48467.1 - 0.85 9.7 4.6 2.3 8.3 0.6 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF83 Glyco_hydro_14 PF01373.17 EFC48468.1 - 4.4e-93 312.4 8.3 3.7e-48 164.5 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 14 LRR_4 PF12799.7 EFC48469.1 - 4e-05 23.9 20.2 0.59 10.6 0.1 6.5 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC48469.1 - 0.00035 20.4 0.0 0.0014 18.4 0.0 2.0 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 EFC48469.1 - 0.0008 19.3 6.7 25 5.2 0.1 5.9 5 0 0 5 5 5 2 Leucine Rich repeat F-box-like PF12937.7 EFC48469.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 F-box-like Use1 PF09753.9 EFC48470.1 - 1.4e-13 51.2 8.7 1.7e-13 50.9 8.7 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 LMBR1 PF04791.16 EFC48470.1 - 0.0031 16.5 5.8 0.004 16.1 5.8 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF1640 PF07798.11 EFC48470.1 - 0.0047 17.0 11.2 0.0047 17.0 11.2 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1640) DUF4559 PF15112.6 EFC48470.1 - 0.18 11.5 14.0 0.15 11.7 13.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) TMF_TATA_bd PF12325.8 EFC48470.1 - 0.26 11.5 20.0 0.21 11.8 14.6 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Nipped-B_C PF12830.7 EFC48470.1 - 0.45 10.4 8.6 2.9 7.8 8.6 2.0 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus DUF1451 PF07295.11 EFC48470.1 - 0.52 10.3 9.7 0.48 10.5 7.9 1.9 1 1 1 2 2 2 0 Zinc-ribbon containing domain Ctr PF04145.15 EFC48470.1 - 0.8 10.3 2.7 1.1 9.9 2.7 1.4 1 1 0 1 1 1 0 Ctr copper transporter family Exonuc_VII_L PF02601.15 EFC48470.1 - 0.85 9.1 8.4 1.2 8.7 8.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Synaptobrevin PF00957.21 EFC48470.1 - 1.3 8.8 11.7 0.036 13.8 4.8 2.0 3 0 0 3 3 2 0 Synaptobrevin YtxH PF12732.7 EFC48470.1 - 2.8 8.5 6.6 50 4.5 6.6 2.5 1 1 0 1 1 1 0 YtxH-like protein SKA1 PF07160.12 EFC48470.1 - 3 7.6 15.6 8.7 6.1 15.6 1.6 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Phage_GPO PF05929.11 EFC48470.1 - 3 7.4 11.7 4.6 6.8 11.6 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase T2SSF PF00482.23 EFC48470.1 - 6 6.9 6.3 25 4.8 3.8 2.8 1 1 0 2 2 2 0 Type II secretion system (T2SS), protein F Methyltransf_32 PF13679.6 EFC48470.1 - 7.2 6.6 9.1 4.2e+02 0.8 9.1 2.2 1 1 0 1 1 1 0 Methyltransferase domain EGF_2 PF07974.13 EFC48471.1 - 7.5e-33 112.6 179.7 0.0006 20.1 11.7 11.8 11 0 0 11 11 11 11 EGF-like domain NHL PF01436.21 EFC48471.1 - 1.7e-07 31.0 0.9 6.7e-05 22.7 0.1 5.0 5 0 0 5 5 5 1 NHL repeat EGF PF00008.27 EFC48471.1 - 0.015 15.6 5.5 0.015 15.6 5.5 11.8 11 0 0 11 11 11 0 EGF-like domain EphA2_TM PF14575.6 EFC48471.1 - 0.017 16.0 0.6 0.077 13.9 0.0 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.10 EFC48471.1 - 0.026 13.9 13.6 0.086 12.3 13.6 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain TMEM154 PF15102.6 EFC48471.1 - 0.031 14.2 2.2 0.085 12.8 2.2 1.7 1 0 0 1 1 1 0 TMEM154 protein family Stevor PF17410.2 EFC48471.1 - 0.038 13.5 1.4 0.097 12.2 1.4 1.6 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF3377 PF11857.8 EFC48471.1 - 0.053 13.5 1.7 0.12 12.3 1.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DUF2207 PF09972.9 EFC48471.1 - 0.13 11.0 0.0 0.23 10.2 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EVI2A PF05399.11 EFC48471.1 - 0.92 9.1 10.6 0.03 13.9 0.9 2.9 2 1 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) Orf78 PF06024.12 EFC48471.1 - 2 8.8 3.9 0.61 10.4 0.2 2.0 2 0 0 2 2 2 0 Orf78 (ac78) Arf PF00025.21 EFC48472.1 - 4.2e-14 52.4 0.2 7.2e-14 51.6 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Erf4 PF10256.9 EFC48472.1 - 3.2e-08 33.7 0.5 8.1e-08 32.4 0.5 1.6 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family G-alpha PF00503.20 EFC48472.1 - 0.0026 17.0 3.2 0.062 12.4 3.2 2.8 1 1 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC48472.1 - 0.0028 17.7 1.1 0.027 14.5 1.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase NOG1 PF06858.14 EFC48472.1 - 0.0044 16.8 0.7 0.019 14.7 0.7 2.1 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) Roc PF08477.13 EFC48472.1 - 0.011 16.0 0.2 0.029 14.6 0.2 1.8 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EFC48472.1 - 0.018 15.3 0.3 0.44 10.8 0.3 2.7 1 1 1 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 EFC48472.1 - 0.019 14.3 2.7 0.14 11.5 0.4 2.4 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_5 PF07728.14 EFC48472.1 - 0.029 14.4 0.0 0.12 12.4 0.0 2.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) E1-E2_ATPase PF00122.20 EFC48472.1 - 0.038 13.5 0.1 0.056 13.0 0.1 1.2 1 0 0 1 1 1 0 E1-E2 ATPase DUF815 PF05673.13 EFC48472.1 - 0.058 12.5 0.1 0.11 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Abhydro_lipase PF04083.16 EFC48472.1 - 0.11 12.1 0.1 0.25 11.0 0.1 1.7 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region AAA_29 PF13555.6 EFC48472.1 - 0.14 12.0 0.1 0.34 10.7 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC48472.1 - 0.14 12.5 0.0 0.46 10.8 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EFC48472.1 - 0.18 12.0 0.0 0.46 10.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain DUF4116 PF13475.6 EFC48473.1 - 1.1e-21 76.3 0.1 5.7e-13 48.4 0.0 2.8 1 1 0 2 2 2 2 Domain of unknown function (DUF4116) LRR_6 PF13516.6 EFC48474.1 - 9.7e-43 140.6 1.9 3.8e-05 23.4 0.0 9.3 9 0 0 9 9 9 7 Leucine Rich repeat LRR_8 PF13855.6 EFC48474.1 - 3.2e-22 78.0 9.6 1.2e-07 31.4 0.0 4.8 2 1 2 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 EFC48474.1 - 2.9e-21 75.2 14.9 0.00052 20.3 0.7 6.5 1 1 6 8 8 8 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48474.1 - 1.2e-13 49.6 2.8 5.8 7.9 0.0 8.9 10 0 0 10 10 10 3 Leucine Rich Repeat DUF4347 PF14252.6 EFC48474.1 - 3.9e-05 23.5 0.8 47 3.8 0.0 6.5 1 1 6 7 7 7 0 Domain of unknown function (DUF4347) LRR_9 PF14580.6 EFC48474.1 - 7.3e-05 22.3 6.8 0.026 14.0 1.3 2.8 1 1 2 3 3 3 3 Leucine-rich repeat Beta_helix PF13229.6 EFC48474.1 - 0.0064 16.3 9.7 0.024 14.5 0.4 2.5 1 1 1 2 2 2 2 Right handed beta helix region DUF1647 PF07801.11 EFC48474.1 - 0.015 15.0 1.4 0.043 13.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) DUF2536 PF10750.9 EFC48475.1 - 0.019 14.8 1.4 0.019 14.8 1.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2536) RRM_1 PF00076.22 EFC48476.1 - 5.7e-10 38.9 0.1 0.00023 20.9 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4244 PF14029.6 EFC48478.1 - 0.12 11.8 1.5 0.26 10.7 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) Hamartin PF04388.12 EFC48478.1 - 4.1 5.9 31.5 5 5.7 31.5 1.2 1 0 0 1 1 1 0 Hamartin protein Kinesin PF00225.23 EFC48479.1 - 5.1e-47 160.4 3.7 5.1e-47 160.4 3.7 2.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC48479.1 - 1.7e-13 50.8 2.1 6.7e-13 48.8 0.0 2.9 2 0 0 2 2 2 1 Microtubule binding Endonuclease_NS PF01223.23 EFC48480.1 - 7.8e-36 124.0 0.0 1.3e-35 123.3 0.0 1.4 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Endonuclea_NS_2 PF13930.6 EFC48480.1 - 0.32 11.1 3.0 0.81 9.8 0.1 2.6 2 1 0 2 2 2 0 DNA/RNA non-specific endonuclease tRNA_synt_1c_R1 PF04558.15 EFC48481.1 - 1.1e-19 71.0 1.6 1.2e-19 70.9 1.6 1.0 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 WD40 PF00400.32 EFC48482.1 - 6.9e-22 77.3 30.0 2.6e-05 24.9 0.7 11.5 13 0 0 13 13 13 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48482.1 - 1.1e-09 38.5 0.4 0.0066 16.7 0.0 6.7 6 1 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain DUF5438 PF17506.2 EFC48482.1 - 0.25 11.7 1.8 0.97 9.8 0.2 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5438) Condensation PF00668.20 EFC48484.1 - 1.7e-08 33.6 0.1 3.5e-08 32.6 0.1 1.4 1 0 0 1 1 1 1 Condensation domain Bact_lectin PF18483.1 EFC48484.1 - 0.082 12.9 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial lectin AOX PF01786.17 EFC48485.1 - 5.7e-76 254.8 0.5 6.7e-76 254.6 0.5 1.0 1 0 0 1 1 1 1 Alternative oxidase APH PF01636.23 EFC48486.1 - 1.1e-13 51.6 0.0 4e-13 49.8 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family TPR_1 PF00515.28 EFC48486.1 - 2.9e-12 45.8 1.0 3.2e-05 23.6 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48486.1 - 2.1e-09 36.8 0.3 0.001 19.0 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48486.1 - 7.4e-07 28.8 3.2 4.4e-05 23.1 1.8 2.5 1 1 1 2 2 2 2 TPR repeat MIT PF04212.18 EFC48486.1 - 5.2e-05 23.2 1.4 0.0013 18.8 0.1 2.6 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 EFC48486.1 - 0.00014 21.8 0.6 0.52 10.7 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48486.1 - 0.0002 21.8 2.0 0.00043 20.7 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat EcKinase PF02958.20 EFC48486.1 - 0.00058 19.3 0.2 0.00058 19.3 0.2 2.0 3 0 0 3 3 3 1 Ecdysteroid kinase TPR_12 PF13424.6 EFC48486.1 - 0.00071 19.8 0.3 0.01 16.1 0.3 2.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48486.1 - 0.005 17.5 0.0 0.01 16.4 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48486.1 - 0.13 12.3 0.1 0.52 10.5 0.0 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_3 PF07720.12 EFC48486.1 - 0.7 9.9 5.2 1.8 8.7 1.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3585 PF12130.8 EFC48486.1 - 5.7 7.1 14.6 0.057 13.6 0.9 3.5 3 1 0 3 3 3 0 Bivalent Mical/EHBP Rab binding domain CH PF00307.31 EFC48487.1 - 1e-26 93.2 5.9 7.4e-13 48.6 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain PH PF00169.29 EFC48487.1 - 2.6e-12 47.2 1.0 2.6e-12 47.2 1.0 2.3 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 EFC48487.1 - 7.1e-05 23.0 0.7 0.00024 21.3 0.7 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain ParG PF09274.10 EFC48487.1 - 0.046 13.9 0.5 0.37 11.0 0.0 2.5 2 0 0 2 2 2 0 ParG CAMSAP_CH PF11971.8 EFC48487.1 - 0.051 13.4 0.0 1.6 8.6 0.0 2.6 2 0 0 2 2 2 0 CAMSAP CH domain SlyX PF04102.12 EFC48487.1 - 3.1 8.5 14.7 0.3 11.7 6.5 3.2 3 0 0 3 3 3 0 SlyX DUF1515 PF07439.11 EFC48487.1 - 6 6.9 10.2 2.2 8.4 5.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1515) Acetyltransf_1 PF00583.25 EFC48489.1 - 4.1e-14 52.8 0.1 9.4e-14 51.7 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC48489.1 - 5.9e-10 39.4 0.3 1.7e-09 38.0 0.3 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC48489.1 - 3.1e-09 36.9 0.0 1.7e-06 28.0 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 EFC48489.1 - 3.1e-05 24.7 0.0 5.2e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC48489.1 - 0.00013 22.1 0.3 0.073 13.1 0.1 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 EFC48489.1 - 0.00053 20.1 0.0 0.00098 19.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 EFC48489.1 - 0.0098 15.8 0.1 0.018 15.0 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein L-fibroin PF05849.11 EFC48489.1 - 0.16 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) Guanylate_cyc PF00211.20 EFC48490.1 - 8.7e-23 80.9 0.0 1.6e-22 80.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PBP_like_2 PF12849.7 EFC48490.1 - 1.4e-19 70.9 0.3 2e-19 70.4 0.3 1.2 1 0 0 1 1 1 1 PBP superfamily domain Tai4 PF16695.5 EFC48490.1 - 0.088 13.3 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase immunity protein DUF4116 PF13475.6 EFC48491.1 - 3.7e-47 157.8 43.1 2.2e-11 43.3 0.7 12.5 8 4 4 12 12 12 11 Domain of unknown function (DUF4116) CAMSAP_CKK PF08683.11 EFC48491.1 - 0.022 14.9 1.8 4.7 7.4 0.0 3.9 3 0 0 3 3 3 0 Microtubule-binding calmodulin-regulated spectrin-associated Peptidase_S8 PF00082.22 EFC48492.1 - 5.5e-38 130.9 0.0 9.3e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Subtilase family DUF1080 PF06439.11 EFC48493.1 - 2.8e-05 24.3 0.1 3.7e-05 23.9 0.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1080) Laminin_G_3 PF13385.6 EFC48493.1 - 0.021 15.0 0.0 0.024 14.8 0.0 1.1 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily zf-TRAF PF02176.18 EFC48494.1 - 3.9e-10 40.3 5.9 3.9e-10 40.3 5.9 2.5 2 1 0 2 2 2 1 TRAF-type zinc finger zf-RING_2 PF13639.6 EFC48494.1 - 2e-07 31.2 12.1 2e-07 31.2 12.1 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC48494.1 - 3.9e-06 26.6 10.3 1.1e-05 25.1 10.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 EFC48494.1 - 7.6e-06 25.7 10.6 7.6e-06 25.7 10.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC48494.1 - 7.6e-05 22.5 13.4 0.00032 20.5 13.4 2.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) LRRFIP PF09738.9 EFC48494.1 - 0.0028 17.2 4.5 0.0028 17.2 4.5 2.0 1 1 0 2 2 2 1 LRRFIP family zf-TRAF_2 PF15965.5 EFC48494.1 - 0.0071 16.8 2.9 0.0071 16.8 2.9 2.2 2 0 0 2 2 1 1 TRAF-like zinc-finger ZapB PF06005.12 EFC48494.1 - 0.013 16.0 4.7 0.013 16.0 4.7 3.1 4 1 0 4 4 2 0 Cell division protein ZapB zf-RING_UBOX PF13445.6 EFC48494.1 - 0.051 13.6 8.1 0.19 11.8 8.1 2.1 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 EFC48494.1 - 0.063 13.6 10.8 0.52 10.6 10.8 2.6 1 1 0 1 1 1 0 RING-H2 zinc finger domain FlaC_arch PF05377.11 EFC48494.1 - 0.21 12.0 2.8 0.52 10.7 1.1 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Prok-RING_4 PF14447.6 EFC48494.1 - 0.58 10.1 18.7 0.16 11.9 12.3 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 EFC48494.1 - 1 9.6 20.2 0.045 13.9 13.5 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING CENP-H PF05837.12 EFC48494.1 - 1.3 9.5 4.8 3.3 8.2 4.3 1.9 1 1 0 1 1 1 0 Centromere protein H (CENP-H) FYVE PF01363.21 EFC48494.1 - 1.5 9.0 18.7 95 3.2 16.4 3.3 1 1 1 2 2 2 0 FYVE zinc finger RasGEF PF00617.19 EFC48495.1 - 2.1e-38 132.3 6.6 2.4e-38 132.1 3.7 2.3 2 0 0 2 2 2 1 RasGEF domain TMEM154 PF15102.6 EFC48495.1 - 0.0048 16.8 0.1 0.015 15.2 0.1 1.8 1 0 0 1 1 1 1 TMEM154 protein family MGC-24 PF05283.11 EFC48495.1 - 5.4 7.5 11.6 0.12 12.9 0.4 3.2 3 0 0 3 3 3 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin 2OG-FeII_Oxy_2 PF13532.6 EFC48497.1 - 9.6e-42 143.4 0.0 1.4e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC48497.1 - 0.083 13.4 0.0 1.5 9.4 0.0 2.3 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 EFC48498.1 - 5.6e-31 107.9 0.4 5.6e-31 107.9 0.4 2.4 2 1 0 2 2 2 1 Protein kinase domain EDR1 PF14381.6 EFC48498.1 - 3e-28 98.9 0.0 7.3e-28 97.7 0.0 1.7 1 0 0 1 1 1 1 Ethylene-responsive protein kinase Le-CTR1 Pkinase_Tyr PF07714.17 EFC48498.1 - 9.8e-20 70.9 0.2 2.2e-19 69.7 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 EFC48498.1 - 0.014 15.0 0.1 0.071 12.7 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Mrpl_C PF18502.1 EFC48498.1 - 2 8.8 5.9 0.49 10.7 0.5 2.6 3 0 0 3 3 3 0 54S ribosomal protein L8 C-terminal domain HI0933_like PF03486.14 EFC48499.1 - 1e-73 248.4 0.0 5.6e-40 137.3 0.0 2.1 1 1 1 2 2 2 2 HI0933-like protein NAD_binding_9 PF13454.6 EFC48499.1 - 1.8e-05 24.8 0.0 2.9e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 EFC48499.1 - 9.9e-05 22.1 0.0 0.066 12.8 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC48499.1 - 0.00022 20.6 0.2 0.034 13.4 0.0 2.4 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC48499.1 - 0.0013 18.9 0.0 0.011 15.9 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 EFC48499.1 - 0.012 14.9 0.0 2.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 EFC48499.1 - 0.017 14.3 0.1 0.6 9.2 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 EFC48499.1 - 0.24 10.4 0.1 4.8 6.2 0.0 2.6 3 0 0 3 3 3 0 FAD binding domain Peptidase_M49 PF03571.15 EFC48500.1 - 1.4e-12 46.8 3.3 6.3e-11 41.3 0.4 2.3 1 1 1 2 2 2 2 Peptidase family M49 Dabb PF07876.12 EFC48501.1 - 5.3e-16 59.0 0.0 6.9e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain NHL PF01436.21 EFC48502.1 - 3.5e-11 42.5 11.2 3.3e-05 23.7 0.4 5.6 5 1 0 5 5 5 4 NHL repeat Lactonase PF10282.9 EFC48502.1 - 0.00014 21.3 0.0 0.01 15.1 0.0 2.7 2 1 0 3 3 3 1 Lactonase, 7-bladed beta-propeller Y_phosphatase2 PF03162.13 EFC48502.1 - 0.026 14.1 0.0 0.34 10.5 0.0 2.3 2 0 0 2 2 2 0 Tyrosine phosphatase family DUF4396 PF14342.6 EFC48503.1 - 1.2e-51 174.8 5.3 1.6e-51 174.3 5.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) Tim29 PF10171.9 EFC48503.1 - 0.0056 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Translocase of the Inner Mitochondrial membrane 29 Carot_N PF09150.10 EFC48503.1 - 0.12 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal G-alpha PF00503.20 EFC48504.1 - 3.2e-31 108.8 17.7 2.4e-29 102.6 17.7 2.0 1 1 0 1 1 1 1 G-protein alpha subunit AFP_2 PF18815.1 EFC48504.1 - 0.0057 16.9 0.2 0.026 14.8 0.0 2.1 2 0 0 2 2 2 1 Bacterial antifreeze protein repeat MMR_HSR1 PF01926.23 EFC48504.1 - 0.017 15.2 0.1 0.17 11.9 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 EFC48504.1 - 0.11 11.8 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.17 EFC48504.1 - 0.12 12.4 0.4 0.84 9.7 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain VIT PF08487.10 EFC48505.1 - 3.4e-22 78.8 0.2 8.6e-22 77.5 0.2 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2135 PF09906.9 EFC48505.1 - 8.5e-06 26.0 0.1 1.9e-05 24.8 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2135) VIT_2 PF13757.6 EFC48505.1 - 7.6e-05 22.5 0.0 0.00019 21.2 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 EFC48505.1 - 0.013 15.5 0.0 0.034 14.1 0.0 1.7 1 1 0 1 1 1 0 von Willebrand factor type A domain TPR_9 PF13371.6 EFC48505.1 - 0.014 15.6 0.0 0.028 14.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF5039 PF16442.5 EFC48505.1 - 0.015 14.9 1.2 0.015 14.9 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5039) EGF_2 PF07974.13 EFC48506.1 - 2.9e-28 97.9 122.2 2.7e-05 24.4 8.7 7.7 7 0 0 7 7 7 7 EGF-like domain NHL PF01436.21 EFC48506.1 - 1.9e-07 30.7 2.4 0.013 15.5 0.2 4.8 4 0 0 4 4 4 2 NHL repeat EGF PF00008.27 EFC48506.1 - 0.0017 18.6 84.4 0.89 9.9 4.9 7.8 7 0 0 7 7 7 7 EGF-like domain Reg_prop PF07494.11 EFC48506.1 - 0.06 13.6 0.7 18 6.0 0.1 4.9 5 0 0 5 5 5 0 Two component regulator propeller Peptidase_M24 PF00557.24 EFC48507.1 - 1e-38 133.1 0.3 1.4e-38 132.7 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Pkinase PF00069.25 EFC48508.1 - 7.7e-72 241.8 0.0 1.1e-71 241.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48508.1 - 8.5e-35 120.3 0.0 1.2e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 EFC48508.1 - 7e-15 55.4 0.0 1.4e-14 54.5 0.0 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 EFC48508.1 - 1.1e-05 25.0 0.0 4.2e-05 23.0 0.0 1.9 1 1 1 2 2 2 1 Kinase-like PH_3 PF14593.6 EFC48508.1 - 8.4e-05 22.6 0.0 0.00029 20.9 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 EFC48508.1 - 0.0001 22.5 0.5 0.00044 20.5 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 EFC48508.1 - 0.0013 19.2 2.3 0.027 14.9 2.3 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain Haspin_kinase PF12330.8 EFC48508.1 - 0.0019 17.2 0.1 0.0026 16.7 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_C PF00433.24 EFC48508.1 - 0.0025 18.5 3.8 0.0059 17.3 3.8 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 EFC48508.1 - 0.0036 16.1 0.0 0.021 13.6 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase PH_16 PF17838.1 EFC48508.1 - 0.016 15.1 0.0 0.045 13.6 0.0 1.8 2 0 0 2 2 2 0 PH domain RWP-RK PF02042.15 EFC48509.1 - 9.8e-19 67.1 0.0 2.4e-18 65.9 0.0 1.7 1 0 0 1 1 1 1 RWP-RK domain DivIC PF04977.15 EFC48509.1 - 8.1 6.3 13.6 0.091 12.5 3.0 2.7 2 0 0 2 2 2 0 Septum formation initiator F-box-like PF12937.7 EFC48510.1 - 1.7e-06 27.8 0.4 4.2e-06 26.6 0.4 1.6 1 0 0 1 1 1 1 F-box-like Phosphodiest PF01663.22 EFC48510.1 - 0.00036 20.2 0.1 0.0007 19.3 0.1 1.5 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase F-box PF00646.33 EFC48510.1 - 0.00046 20.0 2.4 0.00065 19.5 0.0 2.6 3 0 0 3 3 3 1 F-box domain F-box_5 PF18511.1 EFC48510.1 - 0.18 11.4 0.9 0.49 10.0 0.9 1.8 1 0 0 1 1 1 0 F-box DUF4386 PF14329.6 EFC48510.1 - 0.58 10.0 4.3 1 9.2 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) Kelch_4 PF13418.6 EFC48511.1 - 3.4e-22 78.2 7.1 1.8e-06 27.8 0.0 5.6 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC48511.1 - 7.7e-14 51.3 12.1 3e-08 33.5 0.0 5.4 5 1 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFC48511.1 - 3.9e-13 49.3 16.6 1.7e-05 25.0 0.0 7.1 8 0 0 8 8 8 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC48511.1 - 3.1e-12 46.3 9.3 0.00026 21.2 0.0 5.6 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFC48511.1 - 2.1e-08 33.6 15.6 0.00048 19.6 0.1 4.5 4 0 0 4 4 4 3 Kelch motif F-box-like PF12937.7 EFC48511.1 - 4.3e-05 23.3 1.2 0.0001 22.1 1.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48511.1 - 0.029 14.3 0.1 0.079 12.9 0.1 1.7 1 0 0 1 1 1 0 F-box domain DSPn PF14671.6 EFC48512.1 - 5.5e-42 143.6 0.1 2e-41 141.7 0.0 1.9 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 EFC48512.1 - 6.7e-13 48.6 0.0 8.2e-11 41.8 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC48512.1 - 7.6e-07 28.9 0.0 1.4e-05 24.8 0.0 2.2 2 1 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 EFC48512.1 - 1.1e-05 25.6 0.0 2.6e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFC48512.1 - 0.0045 17.0 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PAD_porph PF04371.15 EFC48512.1 - 0.15 11.3 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Porphyromonas-type peptidyl-arginine deiminase Aldo_ket_red PF00248.21 EFC48513.1 - 1.1e-77 261.2 0.2 1.2e-77 261.0 0.2 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HpuA PF16960.5 EFC48513.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Haemoglobin-haptoglobin utilisation, porphyrin transporter ubiquitin PF00240.23 EFC48514.1 - 7.4e-63 208.2 5.9 6.7e-31 105.9 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 EFC48514.1 - 2.9e-30 103.9 7.5 8.2e-15 54.4 1.0 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC48514.1 - 5.5e-09 36.4 3.2 0.0014 19.0 0.3 3.1 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC48514.1 - 1.3e-08 34.6 0.2 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC48514.1 - 1.4e-08 34.8 0.4 0.001 19.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC48514.1 - 5.8e-07 29.8 1.6 0.025 14.9 0.2 2.1 1 1 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 EFC48514.1 - 1.2e-06 29.0 0.1 0.015 15.9 0.0 2.1 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC48514.1 - 9e-05 22.4 6.5 2.6 8.1 0.1 4.0 2 2 2 4 4 4 3 Ubiquitin-like domain Coagulin PF02035.15 EFC48514.1 - 0.043 13.7 0.3 3.3 7.6 0.1 2.2 2 0 0 2 2 2 0 Coagulin DUF3861 PF12977.7 EFC48514.1 - 0.05 13.8 0.6 0.84 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) bPH_3 PF14470.6 EFC48514.1 - 0.072 13.5 1.0 0.84 10.0 0.2 2.5 2 1 0 3 3 3 0 Bacterial PH domain Raf1_HTH PF18579.1 EFC48514.1 - 0.11 12.2 0.0 7 6.4 0.0 2.3 2 0 0 2 2 2 0 Rubisco accumulation factor 1 helix turn helix domain ProRS-C_2 PF09181.10 EFC48514.1 - 0.14 12.3 1.4 17 5.6 0.2 2.2 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal PI3K_rbd PF00794.18 EFC48514.1 - 0.22 11.7 1.5 2.2 8.5 0.2 2.6 2 1 1 3 3 3 0 PI3-kinase family, ras-binding domain UTP25 PF06862.12 EFC48515.1 - 3.6e-106 355.8 13.0 4.8e-106 355.4 13.0 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 EFC48515.1 - 0.12 12.2 2.7 0.26 11.1 0.5 2.6 2 1 0 2 2 2 0 DEAD/DEAH box helicase DUF2340 PF10209.9 EFC48515.1 - 0.42 11.1 7.0 2.3 8.7 0.2 3.7 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2340) Pro_isomerase PF00160.21 EFC48516.1 - 3.7e-47 160.5 0.2 4.3e-47 160.3 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Cupin_8 PF13621.6 EFC48518.1 - 0.017 14.8 4.4 0.02 14.6 3.6 1.4 1 1 0 1 1 1 0 Cupin-like domain Lipase_GDSL PF00657.22 EFC48518.1 - 0.04 13.9 4.4 0.077 13.0 4.2 1.4 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase DUF4337 PF14235.6 EFC48518.1 - 1.3 9.1 4.4 0.48 10.5 0.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) E3_UbLigase_R4 PF13764.6 EFC48519.1 - 4.3e-175 584.2 4.5 4.3e-175 584.2 4.5 3.7 4 0 0 4 4 4 2 E3 ubiquitin-protein ligase UBR4 Pkinase PF00069.25 EFC48520.1 - 1.3e-25 90.3 2.3 4.2e-13 49.3 0.4 3.6 2 1 0 2 2 2 2 Protein kinase domain C2 PF00168.30 EFC48520.1 - 1e-14 54.6 0.0 2.5e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 C2 domain Pkinase_Tyr PF07714.17 EFC48520.1 - 2.9e-14 53.0 0.5 1.6e-06 27.6 0.1 3.8 2 2 0 2 2 2 2 Protein tyrosine kinase Choline_kinase PF01633.20 EFC48520.1 - 0.00057 19.5 1.5 0.018 14.6 0.3 2.3 1 1 1 2 2 2 1 Choline/ethanolamine kinase F-box PF00646.33 EFC48521.1 - 0.14 12.1 2.6 4.2 7.4 0.3 2.5 2 0 0 2 2 2 0 F-box domain SAYSvFN PF10260.9 EFC48522.1 - 0.0013 18.6 0.0 0.005 16.7 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved domain (SAYSvFN) RBDV_coat PF06593.11 EFC48522.1 - 0.093 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Raspberry bushy dwarf virus coat protein NPV_P10 PF05531.12 EFC48523.1 - 0.0021 18.5 2.0 0.0033 17.9 0.9 1.9 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein C2 PF00168.30 EFC48527.1 - 1.5e-07 31.6 0.1 1.1e-06 28.8 0.0 2.3 2 0 0 2 2 2 1 C2 domain DUF2417 PF10329.9 EFC48528.1 - 0.24 10.8 5.9 0.28 10.6 5.9 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) SUR7 PF06687.12 EFC48528.1 - 1.5 8.4 8.2 2 8.0 8.2 1.2 1 0 0 1 1 1 0 SUR7/PalI family SET PF00856.28 EFC48529.1 - 4.5e-23 82.5 2.2 2e-08 34.8 0.1 4.1 2 2 1 3 3 3 3 SET domain SAF PF08666.12 EFC48529.1 - 0.0014 19.2 0.0 3.7 8.3 0.0 3.3 3 0 0 3 3 3 2 SAF domain LRR_6 PF13516.6 EFC48530.1 - 7e-31 103.6 15.7 3.2e-05 23.6 0.1 9.3 9 0 0 9 9 9 8 Leucine Rich repeat LRR_8 PF13855.6 EFC48530.1 - 3e-23 81.3 14.7 1e-06 28.4 0.8 4.4 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 EFC48530.1 - 1.4e-19 69.8 17.8 0.0005 20.4 0.2 6.1 2 2 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48530.1 - 2.6e-10 39.4 14.3 0.15 12.7 0.3 8.8 9 1 0 9 9 9 2 Leucine Rich Repeat CLU_N PF15044.6 EFC48530.1 - 0.23 11.9 2.4 0.69 10.3 0.1 2.8 2 1 0 3 3 3 0 Mitochondrial function, CLU-N-term EGF_2 PF07974.13 EFC48531.1 - 4.5e-18 65.3 93.8 6e-05 23.3 11.0 7.4 7 0 0 7 7 7 5 EGF-like domain EGF PF00008.27 EFC48531.1 - 0.0024 18.2 73.1 0.078 13.3 2.5 7.8 8 0 0 8 8 8 5 EGF-like domain REJ PF02010.15 EFC48532.1 - 6e-32 111.0 46.3 2.9e-28 98.9 13.9 4.6 3 3 0 3 3 3 2 REJ domain EGF_2 PF07974.13 EFC48532.1 - 2.9e-06 27.5 25.9 0.001 19.4 3.4 3.5 3 0 0 3 3 3 2 EGF-like domain I-EGF_1 PF18372.1 EFC48532.1 - 0.00062 19.8 3.3 0.00062 19.8 3.3 3.4 2 1 0 2 2 2 1 Integrin beta epidermal growth factor like domain 1 TcfC PF16967.5 EFC48532.1 - 0.097 12.2 0.1 0.26 10.8 0.1 1.7 1 0 0 1 1 1 0 E-set like domain hEGF PF12661.7 EFC48532.1 - 0.42 11.3 23.2 4.7 8.0 10.0 3.4 2 0 0 2 2 2 0 Human growth factor-like EGF TPR_2 PF07719.17 EFC48533.1 - 3.6e-09 36.1 7.7 0.0012 18.8 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48533.1 - 5.1e-08 32.5 15.1 0.0012 18.9 0.2 6.1 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48533.1 - 7.6e-06 25.5 13.0 0.014 15.2 0.1 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48533.1 - 1.3e-05 25.3 0.3 1.4 9.5 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48533.1 - 0.0015 18.4 0.3 6.2 7.1 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48533.1 - 0.0025 18.0 0.1 1.3 9.4 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48533.1 - 0.0031 18.2 0.1 8.4 7.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF627 PF04781.12 EFC48533.1 - 0.01 15.9 0.2 4.6 7.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF627) TPR_6 PF13174.6 EFC48533.1 - 0.011 16.3 5.7 6.6 7.6 0.1 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48533.1 - 0.045 13.4 1.4 20 5.0 0.0 4.6 4 1 1 5 5 5 0 TPR repeat Retrotran_gag_2 PF14223.6 EFC48533.1 - 0.069 12.8 0.3 0.069 12.8 0.3 2.2 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type Vps39_1 PF10366.9 EFC48533.1 - 0.086 13.1 4.5 0.54 10.6 0.0 3.2 3 1 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 TPR_10 PF13374.6 EFC48533.1 - 0.17 11.8 0.0 14 5.7 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat CNH PF00780.22 EFC48534.1 - 0.0082 15.8 1.7 0.025 14.2 1.7 1.8 1 1 0 1 1 1 1 CNH domain Arginase PF00491.21 EFC48535.1 - 5.3e-52 177.0 0.0 6.8e-52 176.7 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 EFC48535.1 - 0.0048 17.2 0.1 0.95 9.7 0.0 2.3 1 1 1 2 2 2 2 UPF0489 domain CtIP_N PF10482.9 EFC48535.1 - 0.18 11.9 1.5 0.18 11.8 0.2 1.6 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain Kinesin PF00225.23 EFC48536.1 - 4.5e-58 196.8 0.9 5.7e-58 196.4 0.9 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 EFC48536.1 - 1.5e-08 34.7 0.5 3.8e-08 33.4 0.5 1.7 1 0 0 1 1 1 1 Microtubule binding CDC37_C PF08564.10 EFC48536.1 - 0.011 15.8 0.5 0.027 14.6 0.5 1.7 1 0 0 1 1 1 0 Cdc37 C terminal domain AAA_22 PF13401.6 EFC48536.1 - 0.03 14.6 0.0 0.096 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain PAZ PF02170.22 EFC48536.1 - 0.036 13.9 0.6 0.093 12.5 0.6 1.7 1 0 0 1 1 1 0 PAZ domain DUF87 PF01935.17 EFC48536.1 - 0.051 13.7 1.1 0.16 12.0 0.1 2.2 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 EFC48536.1 - 0.081 12.4 0.1 0.18 11.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Ank_2 PF12796.7 EFC48537.1 - 2e-32 111.6 0.6 4.2e-14 52.9 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC48537.1 - 9.1e-26 87.1 0.6 0.00015 21.9 0.0 6.7 7 0 0 7 7 6 5 Ankyrin repeat Ank_4 PF13637.6 EFC48537.1 - 1.9e-22 79.3 1.3 9.5e-07 29.3 0.1 5.2 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 EFC48537.1 - 9.3e-22 76.5 0.6 0.0077 16.6 0.0 7.4 7 0 0 7 7 7 5 Ankyrin repeat LRR_6 PF13516.6 EFC48537.1 - 3.3e-17 61.0 9.9 0.0017 18.2 0.1 6.5 6 0 0 6 6 6 4 Leucine Rich repeat Ank_5 PF13857.6 EFC48537.1 - 1.2e-15 57.3 0.1 0.00075 19.8 0.0 4.8 2 1 3 5 5 5 5 Ankyrin repeats (many copies) LRR_4 PF12799.7 EFC48537.1 - 2.7e-05 24.5 14.3 0.0053 17.1 1.1 4.4 2 1 3 5 5 5 4 Leucine Rich repeats (2 copies) PH PF00169.29 EFC48537.1 - 0.00023 21.6 0.5 0.00051 20.5 0.5 1.6 1 0 0 1 1 1 1 PH domain LRR_8 PF13855.6 EFC48537.1 - 0.0024 17.6 14.8 0.13 12.1 1.3 5.1 2 2 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 EFC48537.1 - 0.02 15.4 4.3 1.6e+02 3.5 0.0 5.6 6 0 0 6 6 4 0 Leucine Rich Repeat CDI PF02234.19 EFC48537.1 - 0.065 13.4 0.2 0.18 12.0 0.2 1.8 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor Mcp5_PH PF12814.7 EFC48537.1 - 0.11 12.6 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology Not1 PF04054.15 EFC48539.1 - 6.7e-134 446.4 4.6 6.7e-134 446.4 4.6 3.0 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 EFC48539.1 - 3.1e-84 281.8 5.4 3.1e-84 281.8 5.4 3.1 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 EFC48539.1 - 8.8e-57 191.3 1.5 8.8e-57 191.3 1.5 2.8 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 EFC48539.1 - 1.7e-44 151.3 3.2 1.7e-44 151.3 3.2 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 EFC48539.1 - 2e-35 122.1 4.0 4e-35 121.1 2.3 2.5 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat OS-D PF03392.13 EFC48539.1 - 0.041 14.0 0.1 0.23 11.6 0.1 2.3 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D DUF3274 PF11678.8 EFC48541.1 - 0.021 14.1 2.2 0.032 13.5 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3274) DUF4116 PF13475.6 EFC48543.1 - 8.2e-37 124.7 22.7 5.7e-12 45.2 0.1 7.1 6 1 1 7 7 7 6 Domain of unknown function (DUF4116) LRR_8 PF13855.6 EFC48544.1 - 6.2e-25 86.7 41.2 1.6e-06 27.8 5.3 8.0 4 1 3 8 8 8 8 Leucine rich repeat LRR_4 PF12799.7 EFC48544.1 - 2.9e-16 59.3 45.8 3.2e-05 24.2 1.5 8.6 5 1 4 10 10 10 8 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC48544.1 - 0.0019 17.7 18.2 1.8 8.0 1.8 5.1 1 1 4 6 6 6 3 Leucine-rich repeat LRR_3 PF07725.12 EFC48544.1 - 0.034 14.0 3.4 1.8 8.5 0.3 4.3 4 0 0 4 4 4 0 Leucine Rich Repeat DUF4571 PF15137.6 EFC48544.1 - 0.1 12.2 1.2 1.8 8.2 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4571) LRR_1 PF00560.33 EFC48544.1 - 2 9.3 34.3 41 5.3 0.2 11.4 12 2 0 12 12 12 0 Leucine Rich Repeat CbtB PF09489.10 EFC48545.1 - 0.72 10.0 3.0 19 5.5 0.1 2.5 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) Comm PF15957.5 EFC48545.1 - 3.9 7.9 5.2 0.88 9.9 0.8 2.1 2 0 0 2 2 2 0 Commissureless DUF2981 PF11200.8 EFC48545.1 - 4.3 7.0 10.4 0.085 12.6 2.9 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2981) Tetraspanin PF00335.20 EFC48545.1 - 4.3 7.0 8.8 0.11 12.2 1.4 2.1 2 0 0 2 2 2 0 Tetraspanin family DHC_N1 PF08385.12 EFC48546.1 - 1.1e-160 536.0 11.0 1.1e-160 536.0 11.0 3.8 4 0 0 4 4 4 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 EFC48546.1 - 6.1e-148 492.1 6.9 1.4e-146 487.7 0.0 5.1 6 0 0 6 6 6 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 EFC48546.1 - 2.8e-112 375.8 13.1 2.8e-112 375.8 13.1 5.8 9 0 0 9 9 7 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFC48546.1 - 1.1e-93 313.4 0.2 4.4e-90 301.5 0.1 3.9 3 0 0 3 3 2 2 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFC48546.1 - 1.9e-90 303.2 0.1 1.9e-90 303.2 0.1 2.6 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFC48546.1 - 9.6e-83 276.6 0.9 9.6e-83 276.6 0.9 3.0 2 0 0 2 2 2 1 ATP-binding dynein motor region MT PF12777.7 EFC48546.1 - 4.9e-75 252.7 17.6 4.9e-75 252.7 17.6 2.0 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 EFC48546.1 - 6.6e-75 250.6 0.8 4.2e-69 231.7 0.1 4.2 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 EFC48546.1 - 4.1e-52 176.3 0.0 1.4e-51 174.6 0.0 2.0 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC48546.1 - 5.2e-35 120.1 0.0 1.2e-20 73.8 0.0 4.6 4 0 0 4 4 3 2 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 EFC48546.1 - 6.4e-30 103.9 0.0 1.9e-11 44.1 0.0 6.6 5 1 0 5 5 5 3 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 EFC48546.1 - 6.4e-29 100.1 2.5 4.3e-28 97.5 0.3 3.6 4 0 0 4 4 2 1 AAA+ lid domain Dynein_AAA_lid PF17852.1 EFC48546.1 - 6.2e-22 78.1 0.0 4.1e-21 75.4 0.0 2.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 EFC48546.1 - 4.1e-09 37.0 2.4 0.0025 18.2 0.0 5.8 5 0 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 EFC48546.1 - 1.4e-08 35.1 0.3 0.27 11.5 0.0 5.1 4 0 0 4 4 4 3 AAA domain AAA PF00004.29 EFC48546.1 - 4.7e-08 33.5 0.5 0.064 13.7 0.0 5.5 5 0 0 5 5 5 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 EFC48546.1 - 6.6e-08 33.2 0.3 0.92 10.1 0.0 5.6 4 0 0 4 4 4 2 AAA domain AAA_30 PF13604.6 EFC48546.1 - 1.9e-07 31.0 2.1 0.054 13.2 0.0 4.7 5 0 0 5 5 5 2 AAA domain DUF815 PF05673.13 EFC48546.1 - 0.00036 19.8 0.0 0.25 10.5 0.0 3.7 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_19 PF13245.6 EFC48546.1 - 0.00052 20.4 3.9 0.054 13.8 0.0 4.7 4 0 0 4 4 3 1 AAA domain AAA_29 PF13555.6 EFC48546.1 - 0.00052 19.7 0.2 12 5.8 0.0 3.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain T2SSE PF00437.20 EFC48546.1 - 0.00058 19.0 0.0 0.29 10.2 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein TsaE PF02367.17 EFC48546.1 - 0.00072 19.6 1.5 0.81 9.7 0.0 4.4 4 0 0 4 4 4 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EFC48546.1 - 0.0014 18.9 1.2 3.1 8.2 0.0 4.5 4 0 0 4 4 3 1 RNA helicase Sigma54_activ_2 PF14532.6 EFC48546.1 - 0.0031 17.6 0.6 5.9 7.0 0.0 4.2 4 0 0 4 4 3 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 EFC48546.1 - 0.0063 16.4 0.1 5.2 7.0 0.0 3.8 3 0 0 3 3 3 0 RsgA GTPase AAA_14 PF13173.6 EFC48546.1 - 0.0069 16.4 2.9 0.039 14.0 0.0 4.0 4 0 0 4 4 1 1 AAA domain Sigma54_activat PF00158.26 EFC48546.1 - 0.0073 16.0 0.0 7.2 6.3 0.0 3.3 3 0 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFC48546.1 - 0.013 16.0 5.3 13 6.3 0.0 5.2 5 0 0 5 5 3 0 ABC transporter Mg_chelatase PF01078.21 EFC48546.1 - 0.016 14.6 0.0 12 5.2 0.0 4.3 5 0 0 5 5 5 0 Magnesium chelatase, subunit ChlI ATP_bind_1 PF03029.17 EFC48546.1 - 0.021 14.6 1.4 3.5 7.3 0.0 3.9 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein NACHT PF05729.12 EFC48546.1 - 0.034 14.1 0.1 4.5 7.2 0.0 3.5 3 0 0 3 3 2 0 NACHT domain AAA_24 PF13479.6 EFC48546.1 - 0.088 12.5 4.2 20 4.8 0.0 4.8 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 EFC48546.1 - 0.13 12.5 1.1 29 4.9 0.1 3.9 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 EFC48546.1 - 0.14 12.3 5.8 2.6 8.2 0.0 4.0 4 0 0 4 4 3 0 AAA domain Cytidylate_kin PF02224.18 EFC48546.1 - 0.16 11.7 3.0 4.8 6.9 0.0 3.6 3 0 0 3 3 3 0 Cytidylate kinase Spectrin PF00435.21 EFC48546.1 - 0.41 11.2 0.0 0.41 11.2 0.0 6.1 6 1 0 6 6 2 0 Spectrin repeat Sec6 PF06046.13 EFC48548.1 - 8.6e-52 176.3 18.9 1.4e-51 175.6 18.9 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 UPF0147 PF03685.13 EFC48548.1 - 0.91 9.6 4.0 6.1 7.0 0.3 3.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0147) Tweety PF04906.13 EFC48550.1 - 7.2e-09 34.8 1.5 1.5e-07 30.5 3.2 2.1 2 0 0 2 2 2 1 Tweety AMIN PF11741.8 EFC48550.1 - 0.12 12.5 0.6 0.33 11.1 0.0 1.9 2 0 0 2 2 2 0 AMIN domain DUF2207 PF09972.9 EFC48550.1 - 0.23 10.2 0.0 0.23 10.2 0.0 3.7 2 1 2 4 4 4 0 Predicted membrane protein (DUF2207) Skp1 PF01466.19 EFC48551.1 - 2.8e-29 101.0 0.8 5.7e-29 100.0 0.8 1.6 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 EFC48551.1 - 1.4e-20 73.2 0.6 3.6e-20 71.9 0.6 1.7 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 EFC48551.1 - 0.025 14.8 0.1 0.27 11.5 0.1 2.1 1 1 0 1 1 1 0 BTB/POZ domain 2OG-FeII_Oxy_2 PF13532.6 EFC48552.1 - 2.1e-26 93.4 0.0 2.4e-26 93.1 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TRAM_LAG1_CLN8 PF03798.16 EFC48553.1 - 2.7e-09 37.0 42.4 1.5e-08 34.6 34.8 2.6 1 1 2 3 3 3 3 TLC domain Mito_carr PF00153.27 EFC48556.1 - 4.8e-06 26.4 0.2 0.0012 18.7 0.1 2.9 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF4211 PF13926.6 EFC48556.1 - 0.031 14.3 0.2 0.15 12.1 0.2 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4211) DUF3907 PF13047.6 EFC48556.1 - 0.032 14.2 0.2 0.14 12.1 0.2 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3907) DUF1732 PF08340.11 EFC48556.1 - 0.11 12.5 1.0 0.37 10.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) DUF2703 PF10865.8 EFC48557.1 - 0.12 12.6 0.2 0.26 11.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) NOA36 PF06524.12 EFC48557.1 - 8.2 5.6 9.1 17 4.6 9.1 1.4 1 0 0 1 1 1 0 NOA36 protein BTB_2 PF02214.22 EFC48558.1 - 2.1e-18 66.5 0.8 2.4e-08 34.2 0.0 3.2 2 1 0 2 2 2 2 BTB/POZ domain WWE PF02825.20 EFC48558.1 - 1.4e-09 38.4 3.5 1.4e-09 38.4 3.5 2.6 2 1 0 2 2 2 1 WWE domain BTB PF00651.31 EFC48558.1 - 0.00012 22.3 0.2 0.0025 18.0 0.0 2.6 2 0 0 2 2 2 1 BTB/POZ domain RCC1 PF00415.18 EFC48559.1 - 1.3e-08 35.3 0.0 1.5e-05 25.5 0.0 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC48559.1 - 5.7e-06 26.0 1.2 1.5e-05 24.6 1.2 1.7 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat Protocadherin PF08374.11 EFC48560.1 - 0.0034 17.4 18.0 0.03 14.3 6.3 2.3 2 0 0 2 2 2 2 Protocadherin Mitofilin PF09731.9 EFC48560.1 - 0.01 14.7 22.9 0.012 14.5 22.9 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SHR3_chaperone PF08229.11 EFC48560.1 - 0.23 10.4 0.0 0.23 10.4 0.0 1.6 2 0 0 2 2 2 0 ER membrane protein SH3 CAML PF14963.6 EFC48560.1 - 3 7.9 10.2 0.89 9.6 0.6 2.1 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand G6B PF15096.6 EFC48560.1 - 4.6 7.0 8.8 1.3 8.7 0.2 2.8 1 1 3 4 4 4 0 G6B family Wzz PF02706.15 EFC48560.1 - 4.8 7.5 6.8 0.38 11.1 0.4 2.5 3 0 0 3 3 3 0 Chain length determinant protein Zip PF02535.22 EFC48560.1 - 5.6 6.1 16.8 0.79 8.9 0.1 2.1 1 1 0 2 2 2 0 ZIP Zinc transporter Macro PF01661.21 EFC48564.1 - 2e-36 124.6 0.3 9.3e-36 122.4 0.3 1.8 1 1 0 1 1 1 1 Macro domain Peptidase_S28 PF05577.12 EFC48565.1 - 9.9e-59 199.2 1.3 2e-58 198.2 1.3 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EFC48565.1 - 0.00023 20.9 0.0 0.00069 19.3 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC48565.1 - 0.07 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2207 PF09972.9 EFC48567.1 - 3.7 6.2 6.4 0.28 9.9 0.7 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Lig_chan PF00060.26 EFC48569.1 - 6.5e-26 91.0 0.3 1e-25 90.3 0.3 1.3 1 0 0 1 1 1 1 Ligand-gated ion channel SBP_bac_3 PF00497.20 EFC48569.1 - 7.2e-26 91.0 0.0 1.6e-25 89.9 0.0 1.5 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 EFC48569.1 - 4.5e-19 68.7 0.0 9.8e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site ST7 PF04184.12 EFC48569.1 - 0.039 12.4 0.0 0.067 11.7 0.0 1.3 1 0 0 1 1 1 0 ST7 protein DUF4834 PF16118.5 EFC48569.1 - 0.11 13.5 1.1 0.99 10.4 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) LMBR1 PF04791.16 EFC48570.1 - 7.1e-26 91.2 32.3 3.5e-19 69.1 5.6 2.0 1 1 1 2 2 2 2 LMBR1-like membrane protein HSP70 PF00012.20 EFC48571.1 - 2.7e-60 204.2 1.1 3.9e-60 203.7 0.3 1.5 1 1 1 2 2 2 1 Hsp70 protein Peptidase_C25_C PF03785.14 EFC48571.1 - 0.086 12.7 0.9 0.27 11.1 0.1 2.2 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain DUF2225 PF09986.9 EFC48572.1 - 0.0047 16.7 8.0 0.032 13.9 8.0 2.2 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) UPF0547 PF10571.9 EFC48572.1 - 0.55 10.4 2.8 15 5.8 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Peptidase_C1 PF00112.23 EFC48573.1 - 1e-75 254.6 7.7 1.4e-75 254.2 7.7 1.2 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFC48573.1 - 5.3e-09 36.4 0.8 8.9e-09 35.7 0.8 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFC48573.1 - 1.8e-05 23.7 0.7 0.016 14.0 0.2 2.4 2 0 0 2 2 2 2 Peptidase C1-like family LptF_LptG PF03739.14 EFC48573.1 - 0.15 10.9 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG adh_short PF00106.25 EFC48574.1 - 6.5e-15 55.1 0.6 2.7e-11 43.3 0.4 3.0 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC48574.1 - 5.4e-08 32.7 0.1 0.0063 16.1 0.1 2.9 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFC48574.1 - 0.0048 16.4 0.0 0.027 14.0 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC48574.1 - 0.0073 15.7 0.1 0.024 14.0 0.1 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC48574.1 - 0.016 14.3 0.1 0.022 13.9 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 EFC48574.1 - 0.024 13.8 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein KR PF08659.10 EFC48574.1 - 0.032 14.1 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 KR domain DUF1198 PF06711.11 EFC48574.1 - 0.11 12.5 0.2 0.19 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) VIT PF08487.10 EFC48575.1 - 1.8e-20 73.2 0.2 5e-20 71.8 0.2 1.8 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain DUF2135 PF09906.9 EFC48575.1 - 1.4e-07 31.7 1.0 3.5e-07 30.4 1.0 1.7 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2135) TPR_9 PF13371.6 EFC48575.1 - 2.1e-05 24.6 0.1 4.1e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat VIT_2 PF13757.6 EFC48575.1 - 0.00029 20.7 0.0 0.00084 19.2 0.0 1.7 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain TPR_12 PF13424.6 EFC48575.1 - 0.024 14.9 0.1 0.048 13.9 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48575.1 - 0.051 13.7 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48575.1 - 0.061 13.2 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48575.1 - 0.12 12.6 0.5 0.58 10.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BRF1 PF07741.13 EFC48575.1 - 1.9 8.9 9.4 0.18 12.2 2.9 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain OATP PF03137.20 EFC48576.1 - 0.0014 17.0 0.5 0.0029 16.0 0.5 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family O-ag_pol_Wzy PF14296.6 EFC48576.1 - 0.21 10.2 3.4 0.2 10.3 0.2 2.0 1 1 1 2 2 2 0 O-antigen polysaccharide polymerase Wzy G6PD_C PF02781.16 EFC48577.1 - 7.3e-111 370.0 0.0 1e-110 369.5 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 EFC48577.1 - 3.6e-49 167.8 0.0 6.1e-49 167.0 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Zn_clus PF00172.18 EFC48578.1 - 2.9e-07 30.5 10.7 6e-07 29.5 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ArdA PF07275.11 EFC48578.1 - 0.0019 18.8 0.0 0.0062 17.1 0.0 1.8 1 0 0 1 1 1 1 Antirestriction protein (ArdA) MTBP_C PF14920.6 EFC48578.1 - 0.48 10.1 11.4 0.041 13.6 5.4 1.9 1 1 1 2 2 2 0 MDM2-binding MFS_1 PF07690.16 EFC48579.1 - 2.5e-21 76.0 7.1 2.5e-21 76.0 7.1 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 EFC48579.1 - 2e-18 66.1 5.1 2e-18 66.1 5.1 2.4 3 0 0 3 3 3 1 Transmembrane secretion effector BT1 PF03092.16 EFC48579.1 - 0.0003 19.2 0.4 0.0031 15.8 0.2 2.3 1 1 1 2 2 2 2 BT1 family Sec62 PF03839.16 EFC48579.1 - 4 6.9 5.9 13 5.2 5.9 1.8 1 0 0 1 1 1 0 Translocation protein Sec62 Actin PF00022.19 EFC48580.1 - 1.3e-65 221.7 0.1 3.6e-63 213.6 0.1 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC48580.1 - 0.0043 15.9 0.1 0.039 12.8 0.1 2.2 1 1 0 1 1 1 1 MreB/Mbl protein F-box-like PF12937.7 EFC48581.1 - 0.14 12.0 1.0 0.54 10.2 0.2 2.4 2 0 0 2 2 2 0 F-box-like UbiA PF01040.18 EFC48582.1 - 0.0047 16.3 2.4 0.0067 15.7 2.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family Hexokinase_1 PF00349.21 EFC48582.1 - 0.078 12.9 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 Hexokinase DUF2207 PF09972.9 EFC48582.1 - 0.13 11.0 1.3 0.19 10.4 1.3 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PI3Ka PF00613.20 EFC48583.1 - 1.2e-15 57.4 1.7 4.3e-15 55.6 0.4 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) LRR_4 PF12799.7 EFC48583.1 - 2e-05 24.9 39.0 0.0018 18.7 1.5 8.2 2 2 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC48583.1 - 0.0013 18.3 7.9 0.084 12.4 0.2 2.8 1 1 1 2 2 2 2 Leucine-rich repeat PI3K_C2 PF00792.24 EFC48583.1 - 0.0071 16.3 0.1 0.019 14.9 0.1 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 LRR_8 PF13855.6 EFC48583.1 - 0.0079 15.9 36.2 0.019 14.7 5.7 6.2 4 2 2 6 6 6 4 Leucine rich repeat LRR_6 PF13516.6 EFC48583.1 - 0.033 14.2 0.1 0.033 14.2 0.1 6.4 8 0 0 8 8 8 0 Leucine Rich repeat Xrn1_D3 PF18194.1 EFC48584.1 - 0.26 11.4 0.1 0.26 11.4 0.1 2.5 3 1 0 3 3 3 0 Exoribonuclease 1 Domain-3 Presenilin PF01080.17 EFC48584.1 - 1.2 7.8 4.7 1.7 7.3 4.7 1.2 1 0 0 1 1 1 0 Presenilin Pet100 PF09803.9 EFC48584.1 - 4.8 7.8 9.5 8.4 7.0 3.8 2.3 2 0 0 2 2 2 0 Pet100 DUF2570 PF10828.8 EFC48584.1 - 7.8 6.4 10.3 0.16 11.8 1.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) O-antigen_lig PF13425.6 EFC48584.1 - 8.3 5.1 10.1 10 4.8 10.1 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Peptidase_U57 PF05582.12 EFC48584.1 - 9.3 5.4 17.7 0.038 13.2 4.5 1.9 1 1 1 2 2 2 0 YabG peptidase U57 PRKCSH_1 PF13015.6 EFC48585.1 - 2.2e-15 56.7 1.5 3.7e-15 55.9 1.5 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 EFC48585.1 - 1.1e-06 29.5 0.9 3.4e-06 28.0 0.9 1.9 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Peptidase_C78 PF07910.13 EFC48585.1 - 0.0049 16.4 0.1 0.19 11.2 0.0 2.4 1 1 1 2 2 2 1 Peptidase family C78 DHR-2 PF06920.13 EFC48586.1 - 1.1e-120 403.8 12.8 1.6e-104 350.4 11.9 4.2 5 0 0 5 5 5 2 Dock homology region 2 DOCK-C2 PF14429.6 EFC48586.1 - 4.1e-42 144.2 2.5 4.1e-42 144.2 2.5 3.3 4 0 0 4 4 4 1 C2 domain in Dock180 and Zizimin proteins TPR_2 PF07719.17 EFC48586.1 - 0.25 11.5 0.8 0.84 9.9 0.4 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat CSG2 PF16965.5 EFC48586.1 - 0.76 8.7 8.8 0.5 9.3 3.9 2.3 2 0 0 2 2 2 0 Ceramide synthase regulator DUF2203 PF09969.9 EFC48586.1 - 8.4 7.1 8.7 32 5.3 3.3 3.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) LRR_4 PF12799.7 EFC48587.1 - 6e-12 45.6 15.9 1.1e-06 28.8 4.2 4.4 1 1 5 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC48587.1 - 5.6e-09 35.6 11.2 0.00023 20.8 2.2 3.3 2 1 1 3 3 3 3 Leucine rich repeat LRR_9 PF14580.6 EFC48587.1 - 0.0025 17.3 2.7 0.0053 16.3 1.9 1.7 1 1 0 1 1 1 1 Leucine-rich repeat SprA-related PF12118.8 EFC48587.1 - 0.039 13.1 23.6 0.048 12.8 23.6 1.2 1 0 0 1 1 1 0 SprA-related family LRR_1 PF00560.33 EFC48587.1 - 0.13 12.9 8.9 3.8 8.4 0.7 5.3 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 EFC48587.1 - 0.19 11.9 8.0 14 6.0 0.7 4.5 3 1 1 4 4 4 0 Leucine Rich repeat Peptidase_S64 PF08192.11 EFC48587.1 - 0.78 8.2 16.5 0.8 8.1 16.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 zf-AD PF07776.15 EFC48588.1 - 0.13 12.5 0.6 0.36 11.1 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) GCK PF07802.11 EFC48589.1 - 0.11 13.0 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 GCK domain DUF4116 PF13475.6 EFC48590.1 - 2.8e-40 135.8 0.5 1.8e-10 40.3 0.0 4.5 2 2 4 6 6 6 6 Domain of unknown function (DUF4116) Helitron_like_N PF14214.6 EFC48590.1 - 0.036 14.3 0.0 0.098 12.9 0.0 1.7 2 1 0 2 2 2 0 Helitron helicase-like domain at N-terminus Cas_Csy4 PF09618.10 EFC48591.1 - 0.072 13.2 4.1 0.11 12.6 4.1 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) DUF771 PF05595.11 EFC48591.1 - 0.1 12.5 1.9 0.47 10.4 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF771) Y_phosphatase3 PF13350.6 EFC48591.1 - 0.14 12.1 2.2 0.22 11.5 2.2 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family RGS PF00615.19 EFC48592.1 - 4.2e-07 30.3 0.2 9.2e-07 29.2 0.2 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Tetraspanin PF00335.20 EFC48592.1 - 7.5 6.2 14.0 3.5 7.3 4.8 3.1 2 1 1 3 3 3 0 Tetraspanin family RGS PF00615.19 EFC48593.1 - 1.4e-07 31.8 1.0 2.7e-07 30.9 0.1 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain Mononeg_mRNAcap PF14318.6 EFC48593.1 - 0.22 10.7 1.4 0.39 9.9 1.4 1.3 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V SecY PF00344.20 EFC48594.1 - 2.3e-73 247.1 11.6 3.1e-73 246.7 11.6 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 EFC48594.1 - 3e-18 65.3 0.1 7.4e-18 64.1 0.1 1.7 1 0 0 1 1 1 1 Plug domain of Sec61p F-box-like PF12937.7 EFC48595.1 - 0.00038 20.3 0.1 0.00071 19.4 0.1 1.4 1 0 0 1 1 1 1 F-box-like DUF3474 PF11960.8 EFC48595.1 - 0.014 15.6 0.2 0.053 13.7 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3474) F-box PF00646.33 EFC48595.1 - 0.029 14.3 0.2 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 F-box domain adh_short PF00106.25 EFC48596.1 - 6.6e-29 100.8 0.3 1.1e-23 83.8 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC48596.1 - 1.3e-21 77.2 0.0 1.2e-17 64.3 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC48596.1 - 1e-06 28.8 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 EFC48596.1 - 0.00012 22.4 0.1 0.00025 21.4 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Epimerase PF01370.21 EFC48596.1 - 0.00052 19.5 0.0 0.00074 19.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 EFC48596.1 - 0.0057 16.0 0.1 0.017 14.4 0.1 1.8 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 EFC48596.1 - 0.037 13.2 0.0 0.055 12.6 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RNA_lig_T4_1 PF09511.10 EFC48596.1 - 0.08 12.8 0.3 1.9 8.3 0.1 2.1 2 0 0 2 2 2 0 RNA ligase ELYS PF13934.6 EFC48596.1 - 0.088 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Nuclear pore complex assembly MIT PF04212.18 EFC48596.1 - 0.15 12.2 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Actin PF00022.19 EFC48597.1 - 5.8e-87 291.9 0.0 8.3e-66 222.3 0.0 2.8 2 1 0 2 2 2 2 Actin F-box-like PF12937.7 EFC48598.1 - 3e-07 30.2 1.8 4.7e-07 29.6 0.7 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC48598.1 - 4.9e-06 26.3 0.0 1.5e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 F-box domain F-box_5 PF18511.1 EFC48598.1 - 0.0066 16.0 0.1 0.026 14.1 0.1 2.0 2 0 0 2 2 2 1 F-box DUF3591 PF12157.8 EFC48598.1 - 0.021 13.5 0.2 0.031 12.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3591) Glutaredoxin2_C PF04399.13 EFC48599.1 - 0.067 13.0 2.5 0.15 11.9 0.8 2.2 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain Pre-PUA PF17832.1 EFC48599.1 - 0.19 12.5 0.2 0.19 12.5 0.2 2.7 2 1 0 2 2 2 0 Pre-PUA-like domain DUF5129 PF17173.4 EFC48599.1 - 0.47 9.5 5.4 0.24 10.5 2.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5129) FTCD_C PF04961.12 EFC48599.1 - 5.2 6.8 11.0 2.5 7.8 2.7 2.8 2 1 0 2 2 2 0 Formiminotransferase-cyclodeaminase TPR_2 PF07719.17 EFC48600.1 - 7e-44 144.4 10.0 1.2e-05 25.1 1.3 12.5 13 0 0 13 13 12 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48600.1 - 2.3e-42 141.1 17.2 4.6e-07 29.4 2.0 11.8 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48600.1 - 1.1e-33 112.5 17.6 0.05 13.8 0.5 12.7 12 0 0 12 12 12 10 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48600.1 - 2.2e-30 104.7 15.7 6.2e-07 29.6 0.1 8.6 5 4 4 9 9 9 8 Tetratricopeptide repeat TPR_6 PF13174.6 EFC48600.1 - 1.9e-27 94.0 0.8 0.028 15.0 0.0 11.6 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFC48600.1 - 2.8e-26 91.8 1.5 3.9e-06 27.3 0.0 7.6 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48600.1 - 8e-22 77.6 0.0 0.001 19.7 0.0 6.9 6 1 2 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48600.1 - 1.5e-21 74.8 10.6 0.0022 17.9 0.0 10.7 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48600.1 - 2.8e-19 68.5 9.7 0.0027 17.3 0.1 9.0 7 1 3 10 10 10 5 TPR repeat ANAPC3 PF12895.7 EFC48600.1 - 2e-17 63.2 19.1 3.9e-05 23.8 4.7 7.4 4 2 4 8 8 8 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC48600.1 - 3e-17 61.7 10.6 0.14 12.6 0.5 10.9 10 1 1 11 11 11 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48600.1 - 1.8e-15 56.3 0.0 3.6 8.7 0.0 9.9 5 3 5 10 10 10 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC48600.1 - 1.1e-08 35.1 0.0 0.55 10.4 0.0 6.1 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC48600.1 - 1.6e-06 27.8 17.2 1 9.3 0.0 8.7 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_21 PF09976.9 EFC48600.1 - 3.3e-06 26.9 19.2 0.00053 19.7 1.8 3.1 3 1 0 3 3 3 2 Tetratricopeptide repeat-like domain TPR_5 PF12688.7 EFC48600.1 - 0.00011 22.4 0.0 0.0053 17.0 0.0 3.3 4 0 0 4 4 4 1 Tetratrico peptide repeat Fis1_TPR_C PF14853.6 EFC48600.1 - 0.00011 22.1 14.4 1.8 8.7 1.3 7.4 5 2 3 8 8 8 2 Fis1 C-terminal tetratricopeptide repeat Coatomer_E PF04733.14 EFC48600.1 - 0.0047 16.4 12.1 0.0071 15.8 0.0 4.2 3 2 2 5 5 5 1 Coatomer epsilon subunit HemY_N PF07219.13 EFC48600.1 - 0.0062 16.7 3.6 0.044 14.0 0.6 3.2 3 0 0 3 3 3 1 HemY protein N-terminus TPR_MalT PF17874.1 EFC48600.1 - 0.012 15.0 6.4 0.46 9.8 0.0 3.7 3 1 0 3 3 3 0 MalT-like TPR region Sel1 PF08238.12 EFC48600.1 - 0.038 14.7 9.2 9 7.1 0.1 6.3 8 0 0 8 8 5 0 Sel1 repeat DUF4810 PF16068.5 EFC48600.1 - 0.46 11.1 0.0 0.46 11.1 0.0 5.4 5 2 1 6 6 4 0 Domain of unknown function (DUF4810) HAUS4 PF14735.6 EFC48601.1 - 7.5e-15 55.3 2.1 7.5e-15 55.3 2.1 1.6 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 4 Fib_alpha PF08702.10 EFC48601.1 - 2.5 8.3 8.8 1.4 9.1 0.6 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family HU-CCDC81_euk_1 PF14908.6 EFC48602.1 - 1.8e-10 40.8 0.3 7.2e-10 38.9 0.0 2.3 2 0 0 2 2 2 1 CCDC81 eukaryotic HU domain 1 Bac_DNA_binding PF00216.21 EFC48602.1 - 9.6e-05 22.5 0.0 0.015 15.5 0.0 3.1 2 0 0 2 2 2 1 Bacterial DNA-binding protein HU-CCDC81_euk_2 PF18289.1 EFC48602.1 - 0.0028 17.8 1.3 0.005 17.0 0.1 2.0 2 0 0 2 2 2 1 CCDC81 eukaryotic HU domain 2 Guanylate_cyc PF00211.20 EFC48603.1 - 1.2e-29 103.3 0.1 2.1e-29 102.4 0.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC48603.1 - 5.6e-08 32.9 8.1 1.4e-07 31.6 8.1 1.7 1 1 0 1 1 1 1 Cache domain DUF4116 PF13475.6 EFC48604.1 - 8.5e-60 198.3 8.0 6.8e-09 35.3 0.0 10.2 7 3 3 10 10 10 9 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC48604.1 - 1.9e-16 60.2 0.0 3.4e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48604.1 - 4.8e-09 35.9 0.0 7.9e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Apc13p PF05839.11 EFC48605.1 - 2e-07 31.1 0.3 1.2e-06 28.6 0.3 2.1 1 1 0 1 1 1 1 Apc13p protein Peptidase_C13 PF01650.18 EFC48607.1 - 7.9e-44 150.1 0.0 1.7e-43 149.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase C13 family adh_short PF00106.25 EFC48607.1 - 3.3e-41 140.9 0.0 5.2e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NPR2 PF06218.11 EFC48607.1 - 1.8e-40 139.0 7.2 8.8e-29 100.5 7.3 3.1 2 1 0 2 2 2 2 Nitrogen permease regulator 2 adh_short_C2 PF13561.6 EFC48607.1 - 2.9e-25 89.2 0.0 4.8e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC48607.1 - 1.3e-08 34.9 0.0 2.3e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC48607.1 - 0.00073 18.8 0.0 0.0014 17.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 EFC48607.1 - 0.032 14.5 0.0 0.078 13.2 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 EFC48607.1 - 0.15 11.5 0.0 0.35 10.3 0.0 1.6 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Rad21_Rec8_N PF04825.13 EFC48608.1 - 8e-19 67.8 0.2 1.9e-18 66.7 0.2 1.6 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 EFC48608.1 - 0.00013 21.2 0.0 0.00031 20.0 0.0 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein U3snoRNP10 PF12397.8 EFC48609.1 - 4.6 7.6 15.8 3.1 8.2 0.4 4.7 5 0 0 5 5 5 0 U3 small nucleolar RNA-associated protein 10 DNA_methylase PF00145.17 EFC48610.1 - 3.5e-27 95.7 0.1 4.9e-26 91.9 0.1 2.1 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase MOZART1 PF12554.8 EFC48610.1 - 0.16 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Mitotic-spindle organizing gamma-tubulin ring associated CPSase_L_D2 PF02786.17 EFC48611.1 - 1e-74 250.6 0.4 2.3e-74 249.5 0.4 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 EFC48611.1 - 1.1e-45 154.7 0.2 3.2e-45 153.2 0.2 1.9 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 EFC48611.1 - 4.7e-33 113.5 0.0 1.4e-32 112.0 0.0 1.9 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain PCC_BT PF18140.1 EFC48611.1 - 1.2e-16 61.2 0.0 2.6e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl PF00364.22 EFC48611.1 - 1.5e-14 53.6 3.7 4.1e-14 52.2 3.7 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp PF02222.22 EFC48611.1 - 1.5e-09 37.7 0.1 3.6e-09 36.4 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 EFC48611.1 - 3.1e-07 30.1 0.1 1.7e-06 27.7 0.1 2.1 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus RimK PF08443.11 EFC48611.1 - 4.1e-05 23.3 0.1 0.00024 20.7 0.1 2.2 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 EFC48611.1 - 8.8e-05 22.6 0.3 0.00091 19.3 0.2 2.4 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 EFC48611.1 - 0.03 14.1 0.9 1.7 8.6 0.1 2.5 1 1 1 2 2 2 0 Biotin-lipoyl like RnfC_N PF13375.6 EFC48611.1 - 0.11 12.4 3.2 0.12 12.3 0.5 2.4 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain TFX_C PF14601.6 EFC48611.1 - 0.22 11.5 1.3 2.4 8.2 0.2 3.2 2 1 0 2 2 2 0 DNA_binding protein, TFX, C-term RCC1 PF00415.18 EFC48612.1 - 1.6e-44 150.3 8.8 1e-07 32.4 0.0 8.0 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC48612.1 - 2.2e-31 107.0 28.5 1.4e-08 34.3 0.1 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat DUF3120 PF11318.8 EFC48612.1 - 0.062 13.7 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) Regnase_1_C PF18561.1 EFC48613.1 - 0.037 13.8 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain TRAM_LAG1_CLN8 PF03798.16 EFC48614.1 - 1.4e-25 90.2 24.0 1.4e-25 90.2 24.0 1.5 2 0 0 2 2 2 1 TLC domain DUF501 PF04417.12 EFC48615.1 - 8.5e-15 54.8 0.1 2e-07 30.9 0.1 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF501) DUF3399 PF11879.8 EFC48615.1 - 7.9 6.9 10.7 0.61 10.4 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) Sedlin_N PF04628.13 EFC48616.1 - 4.6e-43 146.5 1.9 5.2e-43 146.3 1.9 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EFC48616.1 - 2.9e-07 30.5 1.6 1.1e-06 28.6 1.2 1.9 1 1 1 2 2 2 1 Sybindin-like family Fe-S_biosyn PF01521.20 EFC48616.1 - 0.065 13.4 0.1 0.12 12.5 0.0 1.5 1 1 0 1 1 1 0 Iron-sulphur cluster biosynthesis WD40 PF00400.32 EFC48617.1 - 4.2e-06 27.4 0.3 0.4 11.6 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48617.1 - 0.00022 21.5 0.3 1.9 8.8 0.0 4.2 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC48617.1 - 0.018 14.9 1.8 0.026 14.4 0.3 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 EFC48617.1 - 0.026 13.3 0.1 0.28 9.9 0.1 2.0 1 1 2 3 3 3 0 Nup133 N terminal like DUF4215 PF13948.6 EFC48617.1 - 0.027 14.9 1.4 0.084 13.3 1.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) PQQ PF01011.21 EFC48617.1 - 0.17 11.9 0.1 49 4.1 0.0 3.5 4 0 0 4 4 4 0 PQQ enzyme repeat DUF2258 PF10015.9 EFC48618.1 - 0.18 12.0 0.8 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) SpoIIE PF07228.12 EFC48619.1 - 1.8e-05 24.7 0.0 0.019 14.9 0.0 2.2 1 1 1 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 EFC48619.1 - 0.011 15.4 0.1 1.4 8.5 0.0 2.1 1 1 1 2 2 2 0 Protein phosphatase 2C Phosphodiest PF01663.22 EFC48620.1 - 6.3e-87 292.5 0.3 7.6e-87 292.2 0.3 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFC48620.1 - 7.5e-05 22.3 0.1 0.0015 18.0 0.0 2.3 1 1 1 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 EFC48620.1 - 0.0017 17.8 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF229 PF02995.17 EFC48620.1 - 0.1 11.2 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) PglZ PF08665.12 EFC48620.1 - 0.16 12.1 0.1 0.55 10.3 0.0 1.8 2 0 0 2 2 2 0 PglZ domain TEX29 PF15839.5 EFC48620.1 - 0.2 12.3 1.4 16 6.2 1.2 2.3 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein Pkinase PF00069.25 EFC48621.1 - 2.1e-20 73.2 0.0 4.7e-20 72.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48621.1 - 7.3e-16 58.2 0.0 1.6e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase LemA PF04011.12 EFC48621.1 - 0.046 13.6 0.7 0.097 12.5 0.7 1.5 1 0 0 1 1 1 0 LemA family Terminase_2 PF03592.16 EFC48621.1 - 0.15 12.6 0.9 0.32 11.4 0.9 1.5 1 0 0 1 1 1 0 Terminase small subunit SIR2 PF02146.17 EFC48622.1 - 9.5e-27 94.1 1.1 2.8e-26 92.5 0.1 2.2 2 1 0 2 2 2 1 Sir2 family zf-Di19 PF05605.12 EFC48622.1 - 0.0063 16.8 4.0 0.65 10.3 0.3 2.9 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding TPP_enzyme_M PF00205.22 EFC48622.1 - 0.12 12.1 0.0 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain AlaDh_PNT_N PF05222.15 EFC48623.1 - 9.8e-16 58.3 0.0 2.9e-15 56.8 0.0 1.8 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 EFC48623.1 - 5.7e-05 22.5 0.0 8.4e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TMEM208_SND2 PF05620.11 EFC48625.1 - 1.7e-23 83.2 0.2 2.1e-23 83.0 0.2 1.2 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF4834 PF16118.5 EFC48625.1 - 0.03 15.3 0.2 0.036 15.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peroxin-13_N PF04088.13 EFC48625.1 - 0.06 13.6 0.2 0.066 13.5 0.2 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Actin PF00022.19 EFC48626.1 - 7e-105 351.0 0.0 1.4e-104 349.9 0.0 1.4 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC48626.1 - 0.08 11.7 0.0 2.5 6.8 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein RhoGAP PF00620.27 EFC48627.1 - 1.1e-25 90.2 0.1 4.2e-24 85.1 0.0 2.8 2 0 0 2 2 2 1 RhoGAP domain EF-hand_1 PF00036.32 EFC48627.1 - 1.9e-05 23.9 1.1 0.00071 19.0 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 EFC48627.1 - 0.0021 18.5 3.1 0.011 16.2 0.1 3.5 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_8 PF13833.6 EFC48627.1 - 0.01 15.6 0.0 0.05 13.5 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 EFC48627.1 - 0.022 14.2 0.0 0.072 12.6 0.0 1.9 1 0 0 1 1 1 0 EF hand DivIC PF04977.15 EFC48627.1 - 0.028 14.2 3.0 0.87 9.4 2.4 3.0 2 0 0 2 2 2 0 Septum formation initiator V-SNARE PF05008.15 EFC48627.1 - 0.067 13.6 7.4 2.8 8.4 0.2 4.0 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus DUF2730 PF10805.8 EFC48627.1 - 0.16 12.0 6.1 45 4.2 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2730) TolA_bind_tri PF16331.5 EFC48627.1 - 0.18 11.9 8.7 4.1 7.6 2.7 3.5 3 0 0 3 3 3 0 TolA binding protein trimerisation MtrG PF04210.13 EFC48627.1 - 0.32 10.9 1.3 2.1 8.3 0.1 2.7 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Wtap PF17098.5 EFC48627.1 - 0.57 10.1 11.1 0.2 11.6 5.3 2.8 2 1 1 3 3 3 0 WTAP/Mum2p family CENP-H PF05837.12 EFC48627.1 - 0.6 10.5 10.7 0.38 11.2 5.1 2.7 2 1 0 2 2 2 0 Centromere protein H (CENP-H) bZIP_1 PF00170.21 EFC48627.1 - 0.62 10.2 6.5 5.6 7.1 4.2 3.1 2 0 0 2 2 2 0 bZIP transcription factor Cep57_MT_bd PF06657.13 EFC48627.1 - 2.6 8.6 12.3 0.35 11.3 2.3 3.8 2 2 2 4 4 4 0 Centrosome microtubule-binding domain of Cep57 DUF3450 PF11932.8 EFC48627.1 - 2.9 7.1 10.1 2.4 7.4 7.0 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.8 EFC48627.1 - 5.6 7.0 9.2 1.7 8.7 2.7 3.4 3 0 0 3 3 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 EFC48627.1 - 7.4 6.6 13.2 2.6 8.1 0.5 3.8 2 1 2 4 4 3 0 Protein of unknown function (DUF1664) adh_short PF00106.25 EFC48628.1 - 1e-14 54.4 0.0 3.3e-06 26.7 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC48628.1 - 5.5e-10 39.2 0.0 1.6e-07 31.2 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase DUF2810 PF10928.8 EFC48628.1 - 0.062 13.3 0.3 0.16 12.0 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) RWP-RK PF02042.15 EFC48629.1 - 2.7e-22 78.5 0.3 1.2e-21 76.4 0.0 2.1 2 0 0 2 2 2 1 RWP-RK domain DDE_3 PF13358.6 EFC48629.1 - 0.0069 16.2 0.2 0.016 15.0 0.2 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_6 PF01418.17 EFC48629.1 - 0.008 16.1 0.0 0.034 14.1 0.0 2.1 1 0 0 1 1 1 1 Helix-turn-helix domain, rpiR family PRCC PF10253.9 EFC48629.1 - 9.8 6.9 17.1 3.9 8.2 2.5 2.4 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Ribosomal_L21p PF00829.21 EFC48630.1 - 4.4e-32 110.3 1.8 5.5e-32 110.0 1.8 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein DUF4132 PF13569.6 EFC48630.1 - 0.063 13.1 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4132) Pkinase PF00069.25 EFC48631.1 - 1.2e-10 41.3 0.3 6e-10 38.9 0.3 1.8 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EFC48631.1 - 9e-06 25.2 0.0 1.1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_Tyr PF07714.17 EFC48631.1 - 0.0041 16.4 0.0 0.0046 16.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC48631.1 - 0.013 15.4 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family K-box PF01486.17 EFC48632.1 - 0.46 10.7 14.8 0.049 13.8 9.0 2.2 2 0 0 2 2 2 0 K-box region COG4 PF08318.12 EFC48634.1 - 3.2e-61 207.3 11.6 3.2e-61 207.3 11.6 2.1 2 1 0 2 2 2 1 COG4 transport protein Sec10 PF07393.11 EFC48634.1 - 1.1e-09 37.3 1.9 1.1e-09 37.3 1.9 3.2 2 1 0 3 3 3 2 Exocyst complex component Sec10 Alkyl_sulf_dimr PF14863.6 EFC48634.1 - 0.041 14.3 0.2 1.3 9.5 0.2 2.7 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_1 PF00515.28 EFC48634.1 - 0.098 12.5 0.0 0.45 10.4 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF948 PF06103.11 EFC48634.1 - 0.31 11.3 3.0 7.8 6.8 0.4 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF3492 PF11997.8 EFC48634.1 - 5.1 6.7 6.2 6.4 6.4 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3492) FtsX_ECD PF18075.1 EFC48634.1 - 7.1 7.3 11.3 17 6.1 0.1 4.5 4 0 0 4 4 4 0 FtsX extracellular domain DUF4116 PF13475.6 EFC48635.1 - 1.1e-21 76.3 10.1 3e-09 36.5 0.7 4.5 3 1 1 4 4 4 4 Domain of unknown function (DUF4116) ArsD PF06953.11 EFC48635.1 - 0.067 13.6 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Arsenical resistance operon trans-acting repressor ArsD Lung_7-TM_R PF06814.13 EFC48636.1 - 5.7e-36 124.3 31.2 4e-23 82.1 25.9 2.1 2 0 0 2 2 2 2 Lung seven transmembrane receptor UPF0242 PF06785.11 EFC48636.1 - 0.013 15.6 0.4 0.013 15.6 0.4 2.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus SMN PF06003.12 EFC48636.1 - 0.13 11.5 0.4 0.19 11.0 0.4 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF4446 PF14584.6 EFC48636.1 - 3 7.8 6.4 0.32 11.0 0.9 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) Choline_transpo PF04515.12 EFC48637.1 - 3.4e-80 269.7 35.7 3.4e-80 269.7 35.7 2.5 3 0 0 3 3 3 1 Plasma-membrane choline transporter Flp_Fap PF04964.14 EFC48637.1 - 0.00038 20.2 2.4 0.042 13.7 0.1 3.2 2 0 0 2 2 2 2 Flp/Fap pilin component Trp_oprn_chp PF09534.10 EFC48637.1 - 0.77 9.5 8.6 0.2 11.5 0.3 2.9 2 1 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4252 PF14060.6 EFC48639.1 - 0.55 10.1 10.0 2.9 7.8 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4252) HDAC4_Gln PF12203.8 EFC48639.1 - 8.7 6.6 12.9 0.048 13.8 1.6 2.8 2 1 1 3 3 3 0 Glutamine rich N terminal domain of histone deacetylase 4 PRCC PF10253.9 EFC48639.1 - 9.5 6.9 30.0 0.034 14.9 7.1 3.1 2 1 0 3 3 3 0 Mitotic checkpoint regulator, MAD2B-interacting Sid-5 PF17204.3 EFC48641.1 - 1.8 8.8 6.5 0.27 11.4 0.4 2.3 2 1 0 2 2 2 0 Sid-5 family Nic96 PF04097.14 EFC48642.1 - 6.7e-106 355.2 7.4 1.1e-105 354.5 7.4 1.2 1 0 0 1 1 1 1 Nup93/Nic96 DUF5470 PF17564.2 EFC48642.1 - 0.019 15.2 1.1 0.41 10.9 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5470) IBN_N PF03810.19 EFC48642.1 - 0.022 14.7 2.2 0.2 11.6 0.1 3.3 3 0 0 3 3 3 0 Importin-beta N-terminal domain DUF1768 PF08719.11 EFC48642.1 - 0.044 14.0 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1768) DUF5495 PF17599.2 EFC48644.1 - 0.12 12.6 0.1 0.32 11.3 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5495) NHL PF01436.21 EFC48645.1 - 1.8e-08 34.0 1.0 0.018 15.1 0.0 4.8 5 0 0 5 5 5 3 NHL repeat EGF_2 PF07974.13 EFC48645.1 - 0.0015 18.9 33.1 0.0034 17.7 8.0 3.3 2 1 1 3 3 3 2 EGF-like domain DUF5125 PF17163.4 EFC48645.1 - 0.051 13.8 3.9 0.36 11.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5125) AsmA_1 PF13109.6 EFC48646.1 - 0.046 13.2 0.6 0.046 13.2 0.6 1.8 2 0 0 2 2 2 0 AsmA-like C-terminal region AAA_11 PF13086.6 EFC48646.1 - 10 5.8 8.3 2.6 7.7 2.8 1.9 1 1 1 2 2 2 0 AAA domain Med12 PF09497.10 EFC48647.1 - 2.6e-05 24.4 0.0 8e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 EFC48647.1 - 0.00023 20.2 0.1 0.024 13.5 0.3 2.4 1 1 1 2 2 2 2 Eukaryotic Mediator 12 subunit domain Elf4 PF07011.11 EFC48647.1 - 0.00032 20.5 0.6 0.0065 16.4 0.1 3.0 2 0 0 2 2 2 1 Early Flowering 4 domain RNA_pol_Rpb1_3 PF04983.18 EFC48647.1 - 0.11 12.4 8.0 0.091 12.7 0.4 3.4 3 1 0 3 3 3 0 RNA polymerase Rpb1, domain 3 Ribosomal_S3Ae PF01015.18 EFC48648.1 - 1.6e-64 217.2 9.2 1.9e-64 217.0 9.2 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DUF2605 PF10792.9 EFC48648.1 - 0.11 12.5 0.8 0.22 11.5 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) Ras PF00071.22 EFC48649.1 - 2.2e-11 43.6 0.1 6.7e-11 42.0 0.1 1.8 1 0 0 1 1 1 1 Ras family BTB PF00651.31 EFC48649.1 - 0.0014 18.8 3.3 0.075 13.3 0.3 3.1 3 1 0 3 3 3 2 BTB/POZ domain Mito_carr PF00153.27 EFC48650.1 - 1.1e-23 82.9 2.3 6e-10 38.9 0.0 5.1 5 0 0 5 5 5 5 Mitochondrial carrier protein Ras PF00071.22 EFC48651.1 - 2.7e-16 59.6 0.0 3.2e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 EFC48651.1 - 0.0059 16.2 0.1 0.0078 15.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EFC48651.1 - 0.0073 16.5 0.0 0.014 15.7 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SpoOE-like PF09388.10 EFC48651.1 - 0.054 13.4 0.5 0.11 12.4 0.5 1.5 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein Arf PF00025.21 EFC48651.1 - 0.079 12.4 0.5 0.2 11.1 0.2 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC48651.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase Pkinase PF00069.25 EFC48653.1 - 5.3e-35 121.1 0.0 1.4e-34 119.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48653.1 - 4.7e-30 104.7 0.1 3.8e-28 98.5 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase EGF_2 PF07974.13 EFC48653.1 - 7.7e-05 23.0 7.8 0.00016 21.9 7.8 1.6 1 0 0 1 1 1 1 EGF-like domain COX14 PF14880.6 EFC48653.1 - 0.19 11.6 0.6 0.4 10.5 0.6 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DIL PF01843.19 EFC48654.1 - 9.7e-28 96.5 0.3 2.3e-27 95.3 0.3 1.7 1 0 0 1 1 1 1 DIL domain NT-C2 PF10358.9 EFC48654.1 - 1.9e-24 86.0 3.7 1.9e-24 86.0 3.7 1.6 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins PI3K_1B_p101 PF10486.9 EFC48654.1 - 0.71 7.6 11.2 1.1 6.9 11.2 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit AIF_C PF14721.6 EFC48654.1 - 3.5 8.0 6.8 17 5.7 6.8 2.3 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RCC1_2 PF13540.6 EFC48655.1 - 5.4e-08 32.4 0.0 1.3e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC48655.1 - 0.0086 16.7 0.1 2.6 8.7 0.1 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RNase_H PF00075.24 EFC48656.1 - 1.1e-10 41.8 0.4 2.9e-10 40.5 0.4 1.7 1 1 0 1 1 1 1 RNase H Pkinase PF00069.25 EFC48657.1 - 8.1e-23 81.1 0.5 8.1e-23 81.1 0.5 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48657.1 - 2.7e-16 59.7 0.1 4.4e-16 58.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC48657.1 - 0.0024 16.7 0.1 0.0034 16.2 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Arf PF00025.21 EFC48658.1 - 1.8e-52 177.3 0.1 2.2e-52 177.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC48658.1 - 2.6e-10 40.6 0.0 3.8e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC48658.1 - 1.6e-09 37.5 0.0 1.9e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFC48658.1 - 2.2e-07 30.5 0.0 2.8e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC48658.1 - 1.3e-06 27.8 0.1 3e-06 26.7 0.1 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC48658.1 - 7.9e-06 25.4 0.0 8.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MeaB PF03308.16 EFC48658.1 - 0.014 14.4 0.0 0.018 14.0 0.0 1.3 1 1 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 EFC48658.1 - 0.015 14.8 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC48658.1 - 0.08 13.0 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sec7 PF01369.20 EFC48659.1 - 3.3e-38 131.2 3.6 3.3e-38 131.2 3.6 2.9 2 1 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 EFC48659.1 - 0.0009 19.2 5.0 0.0009 19.2 5.0 7.1 6 2 1 7 7 7 1 Guanine nucleotide exchange factor in Golgi transport N-terminal C1_4 PF07975.12 EFC48659.1 - 0.04 14.1 3.7 0.061 13.6 0.1 3.2 3 0 0 3 3 3 0 TFIIH C1-like domain Trypsin PF00089.26 EFC48660.1 - 3.1e-34 118.7 3.1 4e-34 118.4 3.1 1.2 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC48660.1 - 0.0026 18.7 0.2 0.0047 17.8 0.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF1643 PF07799.12 EFC48660.1 - 0.14 12.3 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) PH PF00169.29 EFC48661.1 - 0.031 14.8 0.1 0.27 11.8 0.1 2.6 2 1 0 2 2 2 0 PH domain LRR_6 PF13516.6 EFC48662.1 - 6.9e-81 259.5 20.3 2.3e-05 24.1 0.0 16.6 17 0 0 17 17 17 14 Leucine Rich repeat LRR_8 PF13855.6 EFC48662.1 - 1.2e-50 169.1 28.7 1.6e-09 37.3 0.0 7.4 3 2 7 10 10 10 10 Leucine rich repeat LRR_4 PF12799.7 EFC48662.1 - 3.9e-48 160.6 17.0 2.2e-05 24.7 0.6 10.1 1 1 8 13 13 13 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48662.1 - 5.7e-23 77.9 1.5 9.1 7.3 0.0 14.7 16 1 0 16 16 16 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC48662.1 - 1.7e-17 63.5 4.6 0.0014 18.2 0.1 4.9 1 1 4 5 5 5 4 Leucine-rich repeat DUF4347 PF14252.6 EFC48662.1 - 4.7e-09 36.3 6.8 15 5.4 0.0 10.2 1 1 9 11 11 11 1 Domain of unknown function (DUF4347) ApoB100_C PF12491.8 EFC48662.1 - 0.0043 17.0 29.1 12 5.9 0.1 12.1 6 4 10 16 16 16 1 Apolipoprotein B100 C terminal Beta_helix PF13229.6 EFC48662.1 - 2.1 8.2 15.9 11 5.9 3.1 3.3 1 1 1 2 2 2 0 Right handed beta helix region Big_9 PF17963.1 EFC48663.1 - 1.7e-73 243.4 161.3 4.9e-13 49.6 10.2 12.3 11 1 0 11 11 11 10 Bacterial Ig domain Cadherin_4 PF17803.1 EFC48663.1 - 3.3e-51 171.8 115.8 1e-11 45.2 6.1 11.9 9 2 2 11 11 11 8 Bacterial cadherin-like domain VWA PF00092.28 EFC48663.1 - 1.3e-11 45.1 1.3 4.6e-11 43.3 0.1 2.8 3 0 0 3 3 3 1 von Willebrand factor type A domain Cadherin_5 PF17892.1 EFC48663.1 - 3.2e-08 33.4 94.2 0.00014 21.8 1.7 11.8 10 2 3 13 13 13 7 Cadherin-like domain VWA_2 PF13519.6 EFC48663.1 - 1.1e-07 32.4 1.8 5.5e-07 30.2 0.1 2.7 2 0 0 2 2 2 1 von Willebrand factor type A domain G8 PF10162.9 EFC48664.1 - 1.5e-14 54.2 0.0 3.3e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 G8 domain CHRD PF07452.12 EFC48664.1 - 0.00083 20.3 0.0 0.0024 18.9 0.0 1.8 1 0 0 1 1 1 1 CHRD domain F-box-like PF12937.7 EFC48664.1 - 0.0043 16.9 0.0 0.0043 16.9 0.0 3.9 5 0 0 5 5 5 1 F-box-like DUF1963 PF09234.10 EFC48664.1 - 0.0063 17.0 0.5 0.32 11.4 0.4 2.7 1 1 0 1 1 1 1 Domain of unknown function (DUF1963) DUF1495 PF07381.11 EFC48664.1 - 0.089 12.6 0.0 0.39 10.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix DNA-binding domain (DUF1495) Metallophos PF00149.28 EFC48665.1 - 1.2e-12 48.7 1.6 1.7e-12 48.3 1.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Nop53 PF07767.11 EFC48666.1 - 0.055 12.9 3.4 1.1 8.6 0.0 2.3 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) Trypsin PF00089.26 EFC48667.1 - 1.1e-44 152.9 0.6 1.5e-44 152.5 0.6 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 EFC48667.1 - 0.00014 22.8 0.7 0.00053 20.9 0.0 2.1 1 1 1 2 2 2 1 Trypsin-like peptidase domain Melibiase_2 PF16499.5 EFC48667.1 - 0.11 11.7 0.2 0.17 11.0 0.2 1.2 1 0 0 1 1 1 0 Alpha galactosidase A KASH_CCD PF14662.6 EFC48668.1 - 0.00013 21.9 24.2 0.00038 20.3 20.7 2.8 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH DEAD_assoc PF08494.11 EFC48668.1 - 0.015 15.1 0.6 0.047 13.5 0.6 1.9 1 1 0 1 1 1 0 DEAD/H associated DUF212 PF02681.14 EFC48668.1 - 0.14 12.3 0.1 0.25 11.5 0.1 1.4 1 0 0 1 1 1 0 Divergent PAP2 family DUF1635 PF07795.11 EFC48668.1 - 0.18 11.6 14.5 0.035 14.0 10.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) CD225 PF04505.12 EFC48668.1 - 0.19 11.9 0.0 0.31 11.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-induced transmembrane protein UPF0242 PF06785.11 EFC48668.1 - 0.35 10.9 31.4 0.046 13.8 20.6 2.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF948 PF06103.11 EFC48668.1 - 0.38 11.0 4.5 0.51 10.6 1.5 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 EFC48668.1 - 0.44 9.4 10.4 0.66 8.8 10.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Fib_alpha PF08702.10 EFC48668.1 - 1.1 9.5 18.4 0.92 9.7 12.2 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3800 PF12686.7 EFC48668.1 - 1.3 9.7 4.4 3.2 8.4 4.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF2968 PF11180.8 EFC48668.1 - 8.3 6.0 12.7 0.88 9.2 6.8 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2968) Ferrochelatase PF00762.19 EFC48669.1 - 4.6e-76 255.9 0.1 5.9e-76 255.6 0.1 1.1 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 EFC48669.1 - 0.00059 20.1 0.3 0.0043 17.4 0.0 2.6 4 0 0 4 4 4 1 CbiX HEPN_RiboL-PSP PF18735.1 EFC48669.1 - 0.082 12.8 0.3 0.082 12.8 0.3 2.9 3 1 0 3 3 3 0 RiboL-PSP-HEPN IFP_35_N PF07334.13 EFC48669.1 - 0.96 9.6 8.1 7.3 6.7 0.2 2.7 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF2263 PF10021.9 EFC48670.1 - 3.8e-16 59.8 0.0 1.1e-15 58.3 0.0 1.9 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) CENP-O PF09496.10 EFC48670.1 - 0.12 12.4 0.1 0.21 11.6 0.1 1.3 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component Peptidase_S28 PF05577.12 EFC48673.1 - 9.1e-88 294.9 0.1 1.1e-87 294.7 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 EFC48673.1 - 0.00011 22.0 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC48673.1 - 0.00012 21.5 0.0 0.0002 20.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S37 PF05576.11 EFC48673.1 - 0.0078 14.9 0.1 0.014 14.1 0.1 1.3 1 0 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.21 EFC48673.1 - 0.016 14.7 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 EFC48673.1 - 0.038 14.6 0.0 0.21 12.1 0.0 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF2920 PF11144.8 EFC48673.1 - 0.12 11.5 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Methyltransf_16 PF10294.9 EFC48675.1 - 5.3e-17 62.1 0.2 4.4e-13 49.3 0.0 2.5 1 1 1 2 2 2 2 Lysine methyltransferase EGF_2 PF07974.13 EFC48676.1 - 1.5e-17 63.7 179.4 1.7e-05 25.1 6.6 12.8 11 2 2 13 13 13 9 EGF-like domain RCC1 PF00415.18 EFC48677.1 - 4.5e-19 68.8 8.1 4.6e-09 36.8 0.0 5.6 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC48677.1 - 2.5e-07 30.3 24.6 0.0011 18.7 1.3 6.6 8 0 0 8 8 8 2 Regulator of chromosome condensation (RCC1) repeat Phospholip_A2_1 PF00068.19 EFC48678.1 - 0.0065 16.9 0.0 0.0098 16.4 0.0 1.3 1 0 0 1 1 1 1 Phospholipase A2 Glyco_transf_10 PF00852.19 EFC48679.1 - 4.3e-27 94.9 0.0 1.1e-26 93.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term RGS PF00615.19 EFC48679.1 - 1.3e-10 41.6 13.6 1.4e-09 38.2 0.4 4.0 4 0 0 4 4 4 2 Regulator of G protein signaling domain zf-CCCH_7 PF18586.1 EFC48679.1 - 0.15 12.4 2.4 5.7 7.3 0.1 3.7 3 0 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Prefoldin_2 PF01920.20 EFC48680.1 - 0.0013 18.6 3.9 0.0019 18.1 3.6 1.4 1 1 0 1 1 1 1 Prefoldin subunit KfrA_N PF11740.8 EFC48680.1 - 0.0043 17.7 0.4 0.0053 17.4 0.4 1.1 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term SPOUT_MTase PF02590.17 EFC48680.1 - 0.0075 16.2 0.9 0.0097 15.9 0.9 1.1 1 0 0 1 1 1 1 Predicted SPOUT methyltransferase Med9 PF07544.13 EFC48680.1 - 0.023 14.8 2.3 0.039 14.1 2.3 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF515 PF04415.12 EFC48680.1 - 0.17 10.3 4.3 0.19 10.1 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) FOXP-CC PF16159.5 EFC48680.1 - 0.28 11.8 3.2 0.43 11.2 3.2 1.3 1 0 0 1 1 1 0 FOXP coiled-coil domain M PF02370.16 EFC48680.1 - 9.9 7.1 8.0 1.1 10.1 3.1 2.1 2 0 0 2 2 2 0 M protein repeat Erf4 PF10256.9 EFC48681.1 - 3e-06 27.3 1.9 0.0024 17.9 0.3 2.2 2 0 0 2 2 2 2 Golgin subfamily A member 7/ERF4 family DUF2207 PF09972.9 EFC48681.1 - 0.00021 20.2 0.2 0.00028 19.8 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Choline_transpo PF04515.12 EFC48681.1 - 0.0046 16.2 1.7 0.0069 15.6 1.7 1.2 1 0 0 1 1 1 1 Plasma-membrane choline transporter Phage_holin_3_6 PF07332.11 EFC48681.1 - 0.011 15.8 0.2 0.016 15.2 0.2 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III 7tm_7 PF08395.12 EFC48681.1 - 0.015 14.5 8.6 0.019 14.2 8.6 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor DUF418 PF04235.12 EFC48681.1 - 0.025 14.5 2.1 0.039 13.9 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF418) DUF4381 PF14316.6 EFC48681.1 - 0.062 13.6 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) CcmD PF04995.14 EFC48681.1 - 0.15 12.2 0.1 0.15 12.2 0.1 2.0 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) SRTM1 PF15872.5 EFC48681.1 - 0.17 12.0 1.5 0.43 10.8 0.2 2.1 1 1 1 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 MRAP PF15183.6 EFC48681.1 - 0.23 11.4 1.4 23 5.0 0.2 2.5 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family HemY_N PF07219.13 EFC48681.1 - 1.6 8.9 3.4 35 4.7 0.8 2.3 2 0 0 2 2 2 0 HemY protein N-terminus RCR PF12273.8 EFC48681.1 - 6.5 7.4 13.1 0.33 11.6 3.4 3.1 3 1 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red Guanylate_cyc PF00211.20 EFC48682.1 - 4.8e-15 55.7 1.2 8.6e-15 54.8 1.2 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC48682.1 - 5.2e-05 23.2 2.4 0.00022 21.1 2.4 2.2 1 1 0 1 1 1 1 Cache domain Baseplate PF16774.5 EFC48682.1 - 0.039 13.9 0.7 0.091 12.7 0.7 1.5 1 0 0 1 1 1 0 Baseplate protein E1_UFD PF09358.10 EFC48682.1 - 0.18 12.6 2.3 22 5.8 0.1 3.7 2 1 1 3 3 3 0 Ubiquitin fold domain Profilin PF00235.19 EFC48683.1 - 5.5e-14 52.5 0.1 9.5e-10 38.8 0.1 2.6 1 1 1 2 2 2 2 Profilin DUF4868 PF16162.5 EFC48683.1 - 0.041 13.8 0.0 13 5.7 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4868) DUF3231 PF11553.8 EFC48683.1 - 0.12 12.0 0.2 0.29 10.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3231) RGS PF00615.19 EFC48684.1 - 6.3e-05 23.2 2.2 6.3e-05 23.2 2.2 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain Fam20C PF06702.12 EFC48684.1 - 0.047 13.5 0.4 0.097 12.5 0.4 1.5 1 0 0 1 1 1 0 Golgi casein kinase, C-terminal, Fam20 PrgI PF12666.7 EFC48684.1 - 0.45 11.2 3.7 4 8.2 0.1 2.6 2 0 0 2 2 2 0 PrgI family protein Pex24p PF06398.11 EFC48684.1 - 0.5 9.3 6.2 3.8 6.4 6.2 2.2 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Insulin_TMD PF17870.1 EFC48684.1 - 4 7.6 8.5 8.6 6.5 3.5 2.5 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Orf78 PF06024.12 EFC48684.1 - 6.8 7.1 9.5 1 9.7 1.3 3.3 3 1 0 3 3 3 0 Orf78 (ac78) zf-3CxxC_2 PF17180.4 EFC48685.1 - 0.052 14.3 0.7 1.8 9.4 0.3 2.6 2 0 0 2 2 2 0 Zinc-binding domain Guanylate_cyc PF00211.20 EFC48686.1 - 7.3e-05 22.5 0.4 0.00099 18.8 0.1 2.3 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Synaptobrevin PF00957.21 EFC48686.1 - 0.13 12.1 0.2 0.13 12.1 0.2 2.4 2 0 0 2 2 2 0 Synaptobrevin NPA PF16469.5 EFC48686.1 - 3.8 8.1 9.3 0.87 10.2 2.7 2.5 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 REJ PF02010.15 EFC48687.1 - 7.2e-23 81.1 21.9 1.4e-18 66.9 8.1 2.2 1 1 1 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC48687.1 - 3.6e-08 33.6 106.6 0.0017 18.7 9.1 9.6 8 1 0 8 8 8 8 EGF-like domain KRTAP PF11759.8 EFC48688.1 - 5 7.8 99.1 6.7e+03 -2.3 1.5 5.0 2 1 0 2 2 2 0 Keratin-associated matrix RCC1_2 PF13540.6 EFC48690.1 - 4.4e-13 48.6 10.0 5.9e-06 25.9 0.0 4.9 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC48690.1 - 2.3e-09 37.7 2.1 0.0073 16.9 0.0 3.7 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Diedel PF13164.6 EFC48691.1 - 1.6 9.3 7.4 6.8 7.2 0.9 2.2 1 1 1 2 2 2 0 Diedel Ras PF00071.22 EFC48692.1 - 3.1e-59 199.2 0.5 3.6e-59 199.0 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48692.1 - 1.4e-31 109.2 0.3 2.3e-31 108.5 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48692.1 - 4.7e-12 45.7 0.1 5.8e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC48692.1 - 4.3e-06 26.8 0.1 6.7e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC48692.1 - 6.1e-06 26.2 0.4 0.013 15.4 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC48692.1 - 7.6e-05 22.3 0.5 0.00028 20.5 0.5 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC48692.1 - 0.00034 20.0 0.1 0.00043 19.7 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Raco_middle PF17651.1 EFC48692.1 - 0.0065 16.2 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 RACo middle region Sigma54_activat PF00158.26 EFC48692.1 - 0.01 15.5 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EFC48692.1 - 0.039 14.2 0.0 0.063 13.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 EFC48692.1 - 0.044 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC48692.1 - 0.048 14.1 0.1 0.082 13.3 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 EFC48692.1 - 0.071 13.6 0.2 0.12 12.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 EFC48692.1 - 0.083 12.4 0.5 0.63 9.5 0.5 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_24 PF13479.6 EFC48692.1 - 0.11 12.2 0.1 0.13 11.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain Dynamitin PF04912.14 EFC48692.1 - 0.17 11.2 0.0 0.23 10.8 0.0 1.1 1 0 0 1 1 1 0 Dynamitin DUF615 PF04751.14 EFC48692.1 - 0.18 11.8 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF615) MFS_1 PF07690.16 EFC48694.1 - 5.2e-20 71.7 33.3 5.2e-20 71.7 33.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 EFC48694.1 - 3.6e-06 26.1 29.7 5.2e-06 25.6 29.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter DUF2115 PF09888.9 EFC48695.1 - 0.086 13.4 0.4 0.25 11.9 0.2 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) ApoLp-III PF07464.11 EFC48695.1 - 0.23 11.5 2.9 0.76 9.9 0.4 2.6 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) F-box-like PF12937.7 EFC48696.1 - 0.012 15.5 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 F-box-like PCI PF01399.27 EFC48697.1 - 4.3e-23 81.8 3.0 4.4e-23 81.8 0.8 2.2 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 EFC48697.1 - 0.0081 16.1 0.9 27 5.1 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 EFC48697.1 - 0.011 15.8 1.2 0.021 14.8 0.1 2.2 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family Heme_oxygenase PF01126.20 EFC48697.1 - 0.026 14.3 0.0 0.06 13.1 0.0 1.6 1 0 0 1 1 1 0 Heme oxygenase PriX PF18689.1 EFC48697.1 - 0.051 13.9 4.8 7.3 7.0 0.0 3.3 3 1 0 3 3 3 0 Primase X ACDC PF14733.6 EFC48697.1 - 0.13 12.6 3.3 11 6.4 0.1 3.6 3 0 0 3 3 3 0 AP2-coincident C-terminal TPR_1 PF00515.28 EFC48697.1 - 0.17 11.7 4.1 5.4 7.0 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48697.1 - 0.22 11.7 2.2 5.6 7.3 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat PLDc_2 PF13091.6 EFC48698.1 - 8.6e-21 74.2 1.0 5.1e-13 49.1 0.4 2.5 2 1 0 2 2 2 2 PLD-like domain PLDc PF00614.22 EFC48698.1 - 4.3e-19 67.8 3.7 1.2e-08 34.7 0.1 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif TraA PF05513.11 EFC48698.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 TraA NDUF_C2 PF06374.11 EFC48698.1 - 0.15 12.2 1.1 12 6.1 0.0 3.3 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) FKBP_C PF00254.28 EFC48699.1 - 2.3e-19 69.5 0.0 2.9e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF3885 PF13021.6 EFC48699.1 - 0.13 12.4 0.1 0.22 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) TPR_2 PF07719.17 EFC48700.1 - 7.2e-10 38.2 10.7 0.0088 16.1 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48700.1 - 2.6e-06 27.0 11.6 0.59 10.1 0.1 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48700.1 - 0.0003 21.0 0.3 0.02 15.2 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48700.1 - 0.00081 19.0 6.2 0.8 9.4 0.9 3.8 3 0 0 3 3 3 2 TPR repeat F-box-like PF12937.7 EFC48700.1 - 0.0023 17.8 0.0 0.0057 16.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like TPR_8 PF13181.6 EFC48700.1 - 0.0027 17.8 11.3 0.8 10.1 0.4 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48700.1 - 0.0062 17.2 0.0 2.2 9.0 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat YtxH PF12732.7 EFC48700.1 - 0.1 13.2 0.3 0.1 13.2 0.3 2.6 2 1 1 3 3 3 0 YtxH-like protein Zn_clus PF00172.18 EFC48701.1 - 2.7e-05 24.2 8.2 7.2e-05 22.8 8.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_FA PF12248.8 EFC48701.1 - 0.011 16.1 0.1 0.028 14.8 0.1 1.6 1 0 0 1 1 1 0 Farnesoic acid 0-methyl transferase PCIF1_WW PF12237.8 EFC48702.1 - 3.2e-60 202.6 1.3 6.7e-60 201.6 1.3 1.5 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain Peptidase_S8 PF00082.22 EFC48704.1 - 2.9e-32 112.1 0.0 6.5e-32 111.0 0.0 1.6 1 0 0 1 1 1 1 Subtilase family RGS PF00615.19 EFC48704.1 - 0.0013 19.0 1.3 0.0013 19.0 1.3 4.8 3 1 0 4 4 4 1 Regulator of G protein signaling domain SH3_5 PF08460.10 EFC48704.1 - 0.026 14.6 0.1 0.12 12.5 0.1 2.1 1 0 0 1 1 1 0 Bacterial SH3 domain Pkinase PF00069.25 EFC48705.1 - 6.7e-28 97.8 0.1 1.1e-27 97.1 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48705.1 - 5.8e-16 58.5 0.0 8.9e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC48705.1 - 4.4e-11 42.2 0.4 4.4e-11 42.2 0.4 2.1 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFC48705.1 - 0.00012 22.0 0.0 0.00042 20.3 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 EFC48705.1 - 0.019 14.3 0.2 0.019 14.3 0.2 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RCC1_2 PF13540.6 EFC48706.1 - 1e-36 124.0 5.8 5.2e-09 35.7 0.0 6.6 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC48706.1 - 5.2e-26 91.0 5.9 2.9e-09 37.4 0.0 6.7 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat Pkinase PF00069.25 EFC48707.1 - 3.6e-48 164.2 0.2 1.6e-47 162.1 0.0 2.2 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48707.1 - 2e-31 109.2 0.0 1e-30 106.9 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase NHL PF01436.21 EFC48707.1 - 2.6e-13 49.3 0.0 0.0018 18.2 0.0 5.8 5 0 0 5 5 5 3 NHL repeat EGF_2 PF07974.13 EFC48707.1 - 8e-09 35.7 38.8 0.0013 19.0 4.8 3.9 3 0 0 3 3 3 3 EGF-like domain Pkinase_fungal PF17667.1 EFC48707.1 - 0.018 13.9 19.2 0.35 9.6 19.2 2.2 1 1 0 1 1 1 0 Fungal protein kinase SGL PF08450.12 EFC48707.1 - 0.026 14.1 0.1 5.6 6.5 0.0 3.4 3 1 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_b PF00058.17 EFC48707.1 - 0.036 14.6 0.0 0.68 10.5 0.0 2.7 2 0 0 2 2 2 0 Low-density lipoprotein receptor repeat class B Chordopox_A13L PF05961.11 EFC48707.1 - 0.061 13.6 2.5 0.17 12.2 0.1 2.7 2 0 0 2 2 2 0 Chordopoxvirus A13L protein YSIRK_signal PF04650.17 EFC48707.1 - 0.24 11.3 3.9 0.34 10.8 0.1 2.6 2 0 0 2 2 2 0 YSIRK type signal peptide DUF572 PF04502.13 EFC48707.1 - 1.1 8.8 25.6 2 8.0 25.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) UPF0242 PF06785.11 EFC48707.1 - 1.8 8.6 17.3 3.5 7.7 17.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus O-antigen_lig PF13425.6 EFC48707.1 - 2.9 6.6 7.1 6.3 5.5 7.1 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Adeno_E3_CR2 PF02439.15 EFC48707.1 - 5.1 7.0 9.0 0.11 12.3 1.3 2.3 2 0 0 2 2 1 0 Adenovirus E3 region protein CR2 HMG_box PF00505.19 EFC48708.1 - 7.5e-14 51.9 0.4 1.7e-13 50.8 0.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC48708.1 - 1.5e-05 25.4 1.2 3.5e-05 24.3 1.2 1.6 1 0 0 1 1 1 1 HMG-box domain F-box-like PF12937.7 EFC48708.1 - 0.0021 17.9 0.1 0.027 14.4 0.0 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC48708.1 - 0.02 14.8 0.0 0.098 12.6 0.0 2.3 2 1 0 2 2 2 0 F-box domain CHDNT PF08073.12 EFC48708.1 - 0.06 13.3 0.0 2.3 8.3 0.0 3.3 4 0 0 4 4 4 0 CHDNT (NUC034) domain HSP20 PF00011.21 EFC48709.1 - 2.5e-22 78.9 1.2 3.5e-22 78.5 1.2 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC48709.1 - 1.9e-07 30.5 0.2 3.8e-07 29.6 0.2 1.5 1 1 0 1 1 1 1 HSP20-like domain found in ArsA DUF915 PF06028.11 EFC48709.1 - 0.056 12.8 0.0 0.089 12.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) BRX PF08381.11 EFC48709.1 - 0.1 11.9 0.1 0.28 10.6 0.1 1.7 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 F-box-like PF12937.7 EFC48710.1 - 4.6e-05 23.2 0.2 0.00012 21.9 0.1 1.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC48710.1 - 0.033 14.1 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 F-box domain DUF4166 PF13761.6 EFC48711.1 - 1.2e-30 106.7 0.0 1.7e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4166) E1-E2_ATPase PF00122.20 EFC48712.1 - 1.4e-43 148.5 0.1 1.4e-43 148.5 0.1 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFC48712.1 - 3.3e-40 137.7 8.1 3.3e-40 137.7 8.1 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFC48712.1 - 2.6e-20 73.6 0.5 7.4e-17 62.3 0.5 3.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC48712.1 - 1.2e-19 70.1 0.0 2.8e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC48712.1 - 2.1e-19 69.0 0.0 4.6e-19 67.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC48712.1 - 4.2e-06 26.7 1.2 0.0056 16.4 0.4 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFC48712.1 - 0.098 13.1 0.0 0.69 10.3 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Pkinase_Tyr PF07714.17 EFC48713.1 - 6.3e-56 189.5 0.4 7.3e-49 166.4 0.1 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC48713.1 - 2.7e-55 187.6 0.3 4.4e-55 186.9 0.3 1.3 1 1 0 1 1 1 1 Protein kinase domain Kinase-like PF14531.6 EFC48713.1 - 4.9e-05 22.8 0.0 7.8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC48713.1 - 0.00078 19.4 0.0 0.0015 18.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC48713.1 - 0.0084 15.1 0.5 0.03 13.3 0.3 2.1 2 1 0 2 2 2 1 Haspin like kinase domain DUF4336 PF14234.6 EFC48714.1 - 6.2e-10 38.8 4.6 0.003 16.8 0.0 3.4 4 0 0 4 4 4 3 Domain of unknown function (DUF4336) Lactamase_B_5 PF14597.6 EFC48714.1 - 0.032 13.7 0.0 0.07 12.6 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily HNH_2 PF13391.6 EFC48715.1 - 0.13 12.4 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 HNH endonuclease Polyketide_cyc2 PF10604.9 EFC48716.1 - 1.8e-14 54.2 0.0 2e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport 2OG-FeII_Oxy_3 PF13640.6 EFC48717.1 - 2.6e-06 28.2 0.0 7.9e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 EFC48717.1 - 0.03 15.2 0.7 30 5.7 0.0 4.4 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF4116 PF13475.6 EFC48718.1 - 6.2e-22 77.1 0.2 2.4e-14 52.8 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4116) Tfb5 PF06331.12 EFC48718.1 - 0.15 12.1 0.8 0.56 10.2 0.1 2.3 2 2 1 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 EGF_2 PF07974.13 EFC48719.1 - 9e-58 192.3 354.4 1.4e-05 25.4 4.9 23.3 22 1 0 22 22 22 20 EGF-like domain REJ PF02010.15 EFC48719.1 - 1e-14 54.3 12.7 3.7e-13 49.1 12.7 2.4 1 1 0 1 1 1 1 REJ domain NHL PF01436.21 EFC48719.1 - 6.6e-13 48.0 2.4 0.01 15.9 0.0 8.2 9 0 0 9 9 9 4 NHL repeat 6PGD PF00393.19 EFC48720.1 - 3.3e-129 430.4 0.0 4.2e-129 430.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 EFC48720.1 - 1.2e-47 162.1 0.0 1.8e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 EFC48720.1 - 0.0029 17.5 0.1 0.0077 16.1 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFC48720.1 - 0.0031 18.1 0.0 0.0066 17.0 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 EFC48720.1 - 0.004 17.2 0.0 0.0068 16.5 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 EFC48720.1 - 0.025 14.1 0.1 0.17 11.5 0.0 2.1 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain PGK PF00162.19 EFC48720.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Phosphoglycerate kinase Poxvirus PF06227.12 EFC48721.1 - 0.2 11.4 9.2 0.53 10.0 0.6 2.3 2 0 0 2 2 2 0 dsDNA Poxvirus Pkinase PF00069.25 EFC48722.1 - 2.3e-08 33.7 8.1 5.6e-07 29.2 0.0 3.7 3 1 1 4 4 4 2 Protein kinase domain DUF1053 PF06327.14 EFC48722.1 - 2.9 8.5 6.5 3.6 8.2 0.3 3.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1053) CHAD PF05235.14 EFC48723.1 - 0.0055 16.7 0.2 0.0055 16.7 0.2 1.5 2 0 0 2 2 2 1 CHAD domain DUF3671 PF12420.8 EFC48723.1 - 0.023 14.8 0.9 0.23 11.5 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function SseC PF04888.12 EFC48723.1 - 0.068 12.8 4.5 0.065 12.8 2.5 1.8 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family SPT6_acidic PF14632.6 EFC48723.1 - 0.14 12.8 0.2 0.14 12.8 0.2 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Ctr PF04145.15 EFC48723.1 - 0.7 10.5 5.9 13 6.4 6.2 2.4 1 1 0 1 1 1 0 Ctr copper transporter family Arc_PepC PF06819.11 EFC48724.1 - 0.036 14.2 1.6 1 9.5 0.2 2.7 2 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminal Domain RCC1 PF00415.18 EFC48725.1 - 2.5e-17 63.2 5.3 4.5e-05 24.0 0.0 6.2 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC48725.1 - 1e-15 57.0 12.6 1.5e-08 34.2 0.6 4.4 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat Ribosomal_L14 PF00238.19 EFC48726.1 - 2.3e-37 127.8 0.2 2.9e-37 127.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Peptidase_M28 PF04389.17 EFC48727.1 - 1.9e-23 83.2 0.0 3.7e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 DUF2207 PF09972.9 EFC48727.1 - 0.25 10.1 20.1 2.2 6.9 10.1 4.0 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) TRAPPC-Trs85 PF12739.7 EFC48728.1 - 4e-65 220.4 1.5 6.2e-65 219.7 1.5 1.3 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit SNAP PF14938.6 EFC48728.1 - 0.0046 16.4 0.3 0.022 14.2 0.0 2.2 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP ChaC PF04752.12 EFC48729.1 - 3.9e-43 147.6 0.0 5.1e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 ChaC-like protein ThiP_synth PF10120.9 EFC48729.1 - 0.01 15.4 0.0 0.096 12.3 0.0 2.2 2 0 0 2 2 2 0 Thiamine-phosphate synthase NHL PF01436.21 EFC48731.1 - 0.0046 16.9 2.5 1.6 8.9 0.0 3.4 4 0 0 4 4 4 2 NHL repeat COG7 PF10191.9 EFC48732.1 - 0.021 13.1 4.6 0.021 13.1 0.3 2.3 3 0 0 3 3 3 0 Golgi complex component 7 (COG7) VWA PF00092.28 EFC48733.1 - 2.9e-13 50.4 0.0 4.2e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC48733.1 - 2e-12 47.7 0.0 4e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC48733.1 - 5.3e-09 36.2 0.0 7.2e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_N PF08399.11 EFC48733.1 - 0.00014 22.4 0.1 0.00034 21.1 0.1 1.7 1 0 0 1 1 1 1 VWA N-terminal TMEM100 PF16311.5 EFC48733.1 - 0.05 13.2 0.9 0.14 11.7 0.9 1.7 1 0 0 1 1 1 0 Transmembrane protein 100 dCache_1 PF02743.18 EFC48733.1 - 0.11 12.2 0.0 3.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Cache domain HORMA PF02301.18 EFC48735.1 - 5.9e-23 81.6 0.9 9.3e-23 80.9 0.9 1.3 1 0 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 EFC48735.1 - 0.03 14.1 0.4 0.08 12.8 0.2 1.8 1 1 1 2 2 2 0 Bacterial HORMA domain 2 Csm1_B PF18211.1 EFC48735.1 - 0.12 12.2 0.4 0.65 9.9 0.1 2.1 2 0 0 2 2 2 0 Csm1 subunit domain B LRR_9 PF14580.6 EFC48736.1 - 1.9e-15 56.8 5.7 3.2e-15 56.1 2.9 2.0 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 EFC48736.1 - 3.8e-14 52.6 19.4 1.4e-06 28.5 9.7 3.7 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC48736.1 - 3.7e-13 49.0 32.5 7.5e-08 32.0 9.5 4.2 1 1 3 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 EFC48736.1 - 1.5e-07 30.9 10.5 0.11 12.6 0.1 4.9 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 EFC48736.1 - 1.4e-05 24.9 13.9 2.6 8.9 0.9 5.2 4 0 0 4 4 4 3 Leucine Rich Repeat Guanylin PF02058.15 EFC48736.1 - 0.16 12.5 1.6 0.75 10.3 0.7 2.5 2 1 1 3 3 3 0 Guanylin precursor UQ_con PF00179.26 EFC48738.1 - 1.1e-43 148.3 0.1 1.2e-43 148.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 EFC48738.1 - 0.00014 21.5 0.2 0.00019 21.1 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 EFC48738.1 - 0.016 15.5 0.1 0.018 15.3 0.1 1.3 1 0 0 1 1 1 0 RWD domain Peptidase_M41 PF01434.18 EFC48739.1 - 2.9e-66 223.0 0.1 2.9e-66 223.0 0.1 2.7 3 0 0 3 3 2 1 Peptidase family M41 AAA PF00004.29 EFC48739.1 - 6.6e-43 146.3 0.0 9.2e-42 142.6 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC48739.1 - 9.7e-16 57.3 0.0 3.7e-15 55.5 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain Biotin_lipoyl PF00364.22 EFC48739.1 - 1.8e-05 24.4 0.4 5.5e-05 22.9 0.4 1.8 1 1 0 1 1 1 1 Biotin-requiring enzyme FtsH_ext PF06480.15 EFC48739.1 - 0.00021 21.6 0.1 0.00094 19.5 0.1 2.2 1 0 0 1 1 1 1 FtsH Extracellular TIP49 PF06068.13 EFC48739.1 - 0.00029 20.1 3.7 0.00053 19.3 0.0 2.5 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_5 PF07728.14 EFC48739.1 - 0.00037 20.5 0.0 0.0015 18.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 EFC48739.1 - 0.0004 20.8 0.0 0.0004 20.8 0.0 3.5 3 0 0 3 3 2 1 AAA domain RuvB_N PF05496.12 EFC48739.1 - 0.00049 19.9 0.0 0.0015 18.3 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 EFC48739.1 - 0.0061 17.0 0.2 0.081 13.3 0.1 2.5 1 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 EFC48739.1 - 0.0064 16.7 0.0 0.025 14.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC48739.1 - 0.0064 16.8 0.2 0.11 12.7 0.1 2.6 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 EFC48739.1 - 0.018 14.8 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 EFC48739.1 - 0.025 13.9 0.1 0.082 12.3 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI EMC3_TMCO1 PF01956.16 EFC48739.1 - 0.14 11.9 0.1 0.14 11.9 0.1 2.3 2 1 0 2 2 1 0 Integral membrane protein EMC3/TMCO1-like PTPRCAP PF15713.5 EFC48739.1 - 0.62 10.3 27.8 0.044 14.1 16.4 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Hid1 PF12722.7 EFC48739.1 - 0.98 7.5 11.9 1.8 6.6 11.9 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 EFC48739.1 - 1.3 7.3 24.7 0.0076 14.6 15.0 1.9 2 0 0 2 2 2 0 CDC45-like protein SelP_N PF04592.14 EFC48739.1 - 8.1 5.8 16.6 25 4.2 16.6 1.8 1 0 0 1 1 1 0 Selenoprotein P, N terminal region zf-rbx1 PF12678.7 EFC48740.1 - 2.1e-07 31.1 2.1 2.8e-06 27.5 0.5 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 EFC48740.1 - 8e-06 26.1 1.2 8e-06 26.1 1.2 2.5 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC48740.1 - 2.6e-05 24.0 5.1 9e-05 22.2 1.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFC48740.1 - 3.9e-05 23.6 1.4 0.00033 20.7 0.7 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 EFC48740.1 - 7.3e-05 22.6 4.3 0.00036 20.4 3.5 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC48740.1 - 0.0011 18.8 2.5 0.011 15.5 0.5 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 EFC48740.1 - 0.0016 18.4 0.7 0.0016 18.4 0.7 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 EFC48740.1 - 0.012 15.3 7.8 0.078 12.7 0.4 3.4 3 0 0 3 3 3 0 RING-like zinc finger CitMHS PF03600.16 EFC48740.1 - 0.021 14.1 0.2 0.021 14.0 0.2 1.1 1 0 0 1 1 1 0 Citrate transporter zf-C3HC4_3 PF13920.6 EFC48740.1 - 0.04 13.8 2.5 0.32 10.9 0.6 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC48740.1 - 0.051 13.6 5.9 4.2 7.5 1.6 3.3 2 1 0 2 2 2 0 RING-type zinc-finger FANCL_C PF11793.8 EFC48740.1 - 0.099 12.8 7.7 0.68 10.2 4.7 3.2 2 1 0 2 2 2 0 FANCL C-terminal domain DUF4386 PF14329.6 EFC48740.1 - 0.5 10.2 13.7 5.2 6.9 13.7 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4386) RINGv PF12906.7 EFC48740.1 - 0.98 9.6 4.2 0.78 9.9 1.2 2.1 2 0 0 2 2 2 0 RING-variant domain MMR_HSR1 PF01926.23 EFC48741.1 - 1.8e-16 60.2 0.8 8.1e-14 51.7 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase ACBP PF00887.19 EFC48741.1 - 6.4e-13 48.7 1.2 1.4e-12 47.7 0.0 2.2 2 0 0 2 2 2 1 Acyl CoA binding protein GN3L_Grn1 PF08701.11 EFC48741.1 - 7.8e-13 48.3 21.1 3.1e-12 46.4 21.1 2.0 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase FeoB_N PF02421.18 EFC48741.1 - 1.3e-12 47.6 0.6 6e-08 32.4 0.0 3.3 3 0 0 3 3 3 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC48741.1 - 3.2e-06 27.1 1.0 0.026 14.4 0.1 3.2 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC48741.1 - 0.00029 20.4 6.6 0.0036 16.9 4.3 3.2 2 2 1 3 3 3 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 EFC48741.1 - 0.0067 16.5 0.2 0.0067 16.5 0.2 4.3 2 2 1 3 3 3 1 Dynamin family EspF PF04806.12 EFC48742.1 - 0.091 13.2 1.8 0.095 13.1 0.4 1.8 2 0 0 2 2 2 0 EspF protein repeat TPR_1 PF00515.28 EFC48743.1 - 5e-18 64.1 21.2 0.00013 21.6 0.1 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48743.1 - 5.8e-15 54.1 15.5 0.038 14.1 0.1 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC48743.1 - 5.4e-12 44.9 16.4 0.46 10.8 0.0 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC48743.1 - 6.4e-12 45.5 0.1 0.012 15.8 0.1 5.3 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC48743.1 - 1.4e-10 40.8 8.5 0.011 16.1 0.0 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC48743.1 - 1.1e-09 37.8 11.8 0.0021 17.7 0.0 7.0 6 1 2 8 8 8 2 TPR repeat TPR_12 PF13424.6 EFC48743.1 - 2.9e-09 37.1 2.9 0.056 13.7 0.6 5.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC48743.1 - 9.2e-06 26.0 4.3 0.65 10.7 0.1 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48743.1 - 1.7e-05 25.4 0.2 0.062 14.0 0.4 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC48743.1 - 0.00094 19.8 1.0 39 5.4 0.2 5.5 3 1 3 6 6 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC48743.1 - 0.02 14.4 1.6 0.67 9.5 0.1 3.2 2 0 0 2 2 2 0 SHNi-TPR Fis1_TPR_C PF14853.6 EFC48743.1 - 0.12 12.5 5.4 7 6.8 0.0 4.6 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 EFC48743.1 - 0.17 12.1 10.5 11 6.3 0.1 5.0 3 2 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Ribosomal_L12 PF00542.19 EFC48743.1 - 0.31 11.4 10.1 0.056 13.8 5.2 2.3 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain TPR_7 PF13176.6 EFC48743.1 - 0.6 10.3 3.6 59 4.0 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat SHOCT PF09851.9 EFC48743.1 - 0.68 9.7 5.0 0.29 10.9 1.9 2.0 2 0 0 2 2 2 0 Short C-terminal domain DUF1657 PF07870.11 EFC48743.1 - 2.2 8.3 0.0 2.2 8.3 0.0 6.2 8 0 0 8 8 8 0 Protein of unknown function (DUF1657) DUF1040 PF06288.13 EFC48743.1 - 3.4 8.1 8.4 3.7 8.0 4.8 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1040) CRR7 PF12095.8 EFC48743.1 - 6.1 7.4 8.1 33 5.0 3.6 3.5 2 1 1 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 Histone_HNS PF00816.21 EFC48743.1 - 8.6 7.3 7.1 3 8.7 0.4 2.7 2 0 0 2 2 2 0 H-NS histone family WD40 PF00400.32 EFC48744.1 - 1.1e-08 35.5 8.3 0.004 18.0 0.1 5.7 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48744.1 - 1.1e-06 28.8 3.4 0.42 10.9 0.0 5.1 3 2 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Acyl-CoA_dh_N PF02771.16 EFC48745.1 - 1.7e-30 106.0 0.2 3.4e-30 105.0 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 EFC48745.1 - 1.5e-24 86.9 0.0 2.3e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 EFC48745.1 - 4.3e-22 78.1 0.0 1.1e-21 76.8 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFC48745.1 - 0.0016 18.7 0.1 0.011 16.0 0.1 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain UMP1 PF05348.11 EFC48746.1 - 1.3e-19 70.5 0.1 1.6e-19 70.3 0.1 1.0 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Erf4 PF10256.9 EFC48747.1 - 0.00033 20.7 0.9 0.00089 19.3 0.2 2.0 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family DUF2207 PF09972.9 EFC48747.1 - 0.002 17.0 0.2 0.0021 16.9 0.2 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF371 PF04027.13 EFC48747.1 - 0.096 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF371) BatD PF13584.6 EFC48747.1 - 0.2 10.4 2.7 5.4 5.7 2.7 2.1 1 1 0 1 1 1 0 Oxygen tolerance SBP_bac_3 PF00497.20 EFC48748.1 - 1.9e-11 43.9 0.0 2.6e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Metallophos_C PF14008.6 EFC48748.1 - 0.016 16.1 0.2 0.057 14.3 0.2 2.0 1 0 0 1 1 1 0 Iron/zinc purple acid phosphatase-like protein C F-box-like PF12937.7 EFC48749.1 - 2e-07 30.8 0.0 5.1e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 F-box-like IIGP PF05049.13 EFC48749.1 - 0.089 11.8 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ANAPC2 PF08672.11 EFC48750.1 - 1.5e-19 70.3 0.3 1.5e-18 67.0 0.0 2.8 3 0 0 3 3 3 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 EFC48750.1 - 1.7e-19 69.9 9.6 2.7e-19 69.3 9.6 1.3 1 0 0 1 1 1 1 Cullin family Nore1-SARAH PF16517.5 EFC48750.1 - 0.025 14.5 0.7 0.094 12.6 0.7 2.0 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain UBX PF00789.20 EFC48751.1 - 1e-11 44.9 0.0 2.4e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA PF00627.31 EFC48751.1 - 0.0014 18.4 0.0 0.0027 17.6 0.0 1.4 1 0 0 1 1 1 1 UBA/TS-N domain SR-25 PF10500.9 EFC48751.1 - 0.022 14.4 11.7 0.055 13.1 11.7 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 EFC48751.1 - 0.11 12.8 12.3 0.28 11.5 12.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF4718 PF15842.5 EFC48751.1 - 1.8 8.4 6.8 3.5 7.4 5.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) Dsh_C PF12316.8 EFC48753.1 - 0.17 12.3 11.8 0.23 11.9 11.8 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Zip PF02535.22 EFC48753.1 - 0.24 10.6 6.8 0.23 10.7 6.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 EFC48753.1 - 0.4 10.2 31.4 0.59 9.7 31.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Tim54 PF11711.8 EFC48753.1 - 0.79 8.4 10.9 0.82 8.4 10.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 EFC48753.1 - 1 7.6 14.3 1.1 7.5 14.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 EFC48753.1 - 1.3 7.7 12.9 1.3 7.7 12.9 1.2 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 EFC48753.1 - 9.1 6.6 29.8 2.9 8.2 27.0 1.5 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pkinase PF00069.25 EFC48754.1 - 3.8e-45 154.3 0.7 2.6e-44 151.6 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Sel1 PF08238.12 EFC48754.1 - 5.2e-39 131.8 8.5 3.8e-10 40.1 0.1 5.6 5 0 0 5 5 5 5 Sel1 repeat Pkinase_Tyr PF07714.17 EFC48754.1 - 3.8e-28 98.5 0.0 9.7e-28 97.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase TAF1_subA PF14929.6 EFC48754.1 - 0.028 13.9 0.7 0.057 12.8 0.7 1.7 1 1 0 1 1 1 0 TAF RNA Polymerase I subunit A STAT_bind PF02864.15 EFC48754.1 - 0.65 10.5 3.3 1.6 9.3 3.3 1.7 1 0 0 1 1 1 0 STAT protein, DNA binding domain Macoilin PF09726.9 EFC48754.1 - 3.8 5.9 9.2 5.4 5.4 9.2 1.1 1 0 0 1 1 1 0 Macoilin family Ge1_WD40 PF16529.5 EFC48756.1 - 2.2e-15 56.4 2.3 5.6e-15 55.1 2.3 1.7 1 1 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 EFC48756.1 - 8.3e-05 23.3 0.1 0.61 11.0 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48756.1 - 0.0022 18.3 0.0 0.17 12.2 0.0 2.7 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF445 PF04286.12 EFC48756.1 - 0.0042 16.9 6.9 0.0074 16.1 6.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Nbas_N PF15492.6 EFC48756.1 - 0.081 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Hira PF07569.11 EFC48756.1 - 0.23 11.1 0.0 0.23 11.1 0.0 3.7 4 0 0 4 4 4 0 TUP1-like enhancer of split MIEAP PF16026.5 EFC48756.1 - 0.37 11.0 4.2 1.1 9.5 4.2 1.9 1 1 0 1 1 1 0 Mitochondria-eating protein CelTOS PF18659.1 EFC48756.1 - 1.8 9.0 9.2 2.3 8.7 1.1 3.2 2 1 1 3 3 3 0 Cell-traversal protein for ookinetes and sporozoites p450 PF00067.22 EFC48757.1 - 1.3e-67 228.6 0.5 1.6e-67 228.3 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M32 PF02074.15 EFC48758.1 - 0.15 10.8 11.3 0.23 10.2 11.3 1.3 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase DUF3135 PF11333.8 EFC48758.1 - 0.61 10.4 3.5 23 5.3 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3135) WD40 PF00400.32 EFC48760.1 - 1.1e-09 38.8 10.2 6.6e-06 26.8 0.3 4.3 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48760.1 - 2.6e-05 24.4 1.2 0.14 12.4 0.1 3.9 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC48760.1 - 0.00095 17.9 2.2 0.00095 17.9 2.2 2.4 1 1 1 2 2 2 1 Nucleoporin Nup120/160 FAD_binding_7 PF03441.14 EFC48761.1 - 6.3e-58 195.6 0.3 1.4e-57 194.5 0.3 1.6 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 EFC48761.1 - 7.6e-17 61.8 0.0 2.7e-10 40.5 0.0 2.3 1 1 1 2 2 2 2 DNA photolyase PepSY_like PF11396.8 EFC48761.1 - 1.5 9.4 8.2 0.35 11.5 3.4 2.6 2 1 0 2 2 2 0 Putative beta-lactamase-inhibitor-like, PepSY-like A_deaminase PF00962.22 EFC48763.1 - 5.3e-60 203.5 0.1 2.7e-59 201.2 0.1 1.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase PBP1_TM PF14812.6 EFC48764.1 - 0.074 13.4 7.8 0.31 11.4 6.0 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 PF15387.6 EFC48764.1 - 4.1 7.7 10.7 0.4 10.9 5.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 EFC48764.1 - 5.4 6.2 8.6 3.4 6.9 6.2 1.8 2 0 0 2 2 2 0 NOA36 protein LRR_6 PF13516.6 EFC48765.1 - 5e-36 119.7 10.2 0.00014 21.6 0.0 8.6 9 0 0 9 9 9 7 Leucine Rich repeat LRR_8 PF13855.6 EFC48765.1 - 8.3e-20 70.3 7.4 6.3e-05 22.7 0.0 4.3 1 1 5 6 6 6 6 Leucine rich repeat LRR_4 PF12799.7 EFC48765.1 - 3e-18 65.6 0.9 0.0011 19.3 0.0 5.4 2 2 4 7 7 7 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC48765.1 - 8e-08 32.0 0.1 0.0035 16.9 0.0 2.5 1 1 1 2 2 2 2 Leucine-rich repeat ApoB100_C PF12491.8 EFC48765.1 - 2.5e-07 30.6 8.8 4.4 7.4 0.0 6.9 2 2 5 8 8 8 3 Apolipoprotein B100 C terminal LRR_1 PF00560.33 EFC48765.1 - 2.1e-06 27.5 0.0 68 4.6 0.0 6.8 8 0 0 8 8 7 0 Leucine Rich Repeat Spidroin_N PF16763.5 EFC48765.1 - 0.0026 17.8 2.0 6.6 6.8 0.1 4.7 3 3 3 6 6 6 1 Major ampullate spidroin 1, spider silk protein 1, N-term DUF4347 PF14252.6 EFC48765.1 - 0.013 15.3 0.4 68 3.3 0.0 4.6 1 1 5 6 6 6 0 Domain of unknown function (DUF4347) PulA_N1 PF17999.1 EFC48765.1 - 0.03 15.1 0.3 1.1 10.0 0.0 2.6 1 1 0 2 2 2 0 Pullulanase N1-terminal domain DUF4869 PF16163.5 EFC48765.1 - 0.076 12.7 0.7 3.2 7.5 0.0 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF4869) Apo-VLDL-II PF05418.11 EFC48765.1 - 0.16 12.6 0.0 21 5.8 0.0 3.4 1 1 3 4 4 4 0 Apovitellenin I (Apo-VLDL-II) SNF2_N PF00176.23 EFC48766.1 - 1.5e-63 214.7 0.7 3.2e-63 213.6 0.7 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3535 PF12054.8 EFC48766.1 - 9.3e-58 196.5 2.8 9.3e-58 196.5 2.8 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) HEAT PF02985.22 EFC48766.1 - 9.5e-20 69.0 2.7 0.29 11.5 0.0 9.1 8 0 0 8 8 8 5 HEAT repeat Helicase_C PF00271.31 EFC48766.1 - 6.5e-18 65.1 0.4 2.9e-17 63.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT_2 PF13646.6 EFC48766.1 - 1.9e-06 28.2 5.9 0.00052 20.3 0.1 5.2 6 1 1 7 7 7 1 HEAT repeats DEAD PF00270.29 EFC48766.1 - 0.00021 21.1 0.0 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase HEAT_EZ PF13513.6 EFC48766.1 - 0.00064 20.2 11.1 24 5.5 0.2 7.7 9 0 0 9 9 9 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 EFC48766.1 - 0.03 14.9 0.8 0.58 10.8 0.1 3.3 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Arm PF00514.23 EFC48766.1 - 0.095 12.8 2.2 23 5.2 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat IFRD PF05004.13 EFC48766.1 - 0.79 8.8 8.3 7.4 5.6 0.1 4.7 4 1 1 5 5 5 0 Interferon-related developmental regulator (IFRD) UME PF08064.13 EFC48766.1 - 1.6 8.7 9.3 64 3.5 0.0 5.2 5 0 0 5 5 5 0 UME (NUC010) domain zf-CCCH PF00642.24 EFC48767.1 - 2.4e-18 65.5 28.2 2.2e-05 24.2 0.8 4.1 3 1 1 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 EFC48767.1 - 3.7e-15 55.4 32.0 1.3e-06 28.2 1.8 5.2 5 0 0 5 5 5 4 Zinc finger domain zf-CCCH_4 PF18044.1 EFC48767.1 - 2.3e-09 36.8 25.1 2e-05 24.3 0.7 3.8 4 0 0 4 4 4 3 CCCH-type zinc finger Torus PF16131.5 EFC48767.1 - 1.6e-08 35.2 20.3 0.00068 20.3 0.9 4.0 1 1 3 4 4 4 3 Torus domain zf-CCCH_2 PF14608.6 EFC48767.1 - 2.1e-07 31.2 27.1 0.029 14.8 4.0 5.1 4 1 1 5 5 5 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 EFC48767.1 - 0.00081 19.6 17.5 0.0061 16.8 10.8 2.9 1 1 1 2 2 2 2 Zinc-finger containing family zf-C3H1 PF10650.9 EFC48767.1 - 0.2 11.4 17.6 2.5 7.9 0.6 4.8 4 1 0 4 4 4 0 Putative zinc-finger domain WH2 PF02205.20 EFC48768.1 - 0.00017 21.3 0.4 0.00017 21.3 0.4 2.7 3 0 0 3 3 3 1 WH2 motif MFAP1 PF06991.11 EFC48768.1 - 0.0054 16.6 12.9 0.0054 16.6 12.9 2.1 2 0 0 2 2 2 1 Microfibril-associated/Pre-mRNA processing Drf_FH1 PF06346.12 EFC48768.1 - 0.065 13.0 65.3 0.3 10.8 65.4 2.0 1 1 0 1 1 1 0 Formin Homology Region 1 RRM_1 PF00076.22 EFC48769.1 - 1.2e-49 166.0 0.0 1.1e-18 66.9 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC48769.1 - 4.1e-07 29.8 0.0 4.6e-06 26.4 0.0 2.5 3 1 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFC48769.1 - 0.00048 20.1 0.0 0.0027 17.6 0.0 2.1 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 EFC48769.1 - 0.0015 18.6 0.1 1.7 8.8 0.0 3.0 3 1 0 3 3 3 2 RNA recognition motif Cas_Cas2CT1978 PF09707.10 EFC48769.1 - 0.0023 17.9 0.0 0.22 11.6 0.0 2.6 2 1 1 3 3 3 1 CRISPR-associated protein (Cas_Cas2CT1978) RRM_5 PF13893.6 EFC48769.1 - 0.0066 16.0 0.0 0.098 12.3 0.0 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 EFC48769.1 - 0.0078 16.3 0.1 0.13 12.4 0.0 2.5 2 1 0 2 2 2 1 Limkain b1 RRM_3 PF08777.11 EFC48769.1 - 0.042 13.9 0.0 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 RNA binding motif PHM7_cyt PF14703.6 EFC48769.1 - 0.082 13.1 0.0 3.1 8.0 0.0 2.7 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter DUF5586 PF17824.1 EFC48771.1 - 0.055 12.6 0.0 0.075 12.1 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5586) Cas_Csa5 PF09702.10 EFC48771.1 - 0.12 12.6 0.1 0.58 10.4 0.0 2.0 1 1 0 2 2 2 0 CRISPR-associated protein (Cas_Csa5) ZZ PF00569.17 EFC48772.1 - 8.8e-13 47.8 7.4 8.8e-13 47.8 7.4 3.8 4 1 0 4 4 4 1 Zinc finger, ZZ type zf-C3HC4_3 PF13920.6 EFC48772.1 - 4.2e-12 45.7 17.3 4.2e-12 45.7 17.3 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC48772.1 - 0.00039 20.7 16.9 0.00039 20.7 16.9 4.0 3 1 0 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 EFC48772.1 - 0.0012 18.7 16.0 0.0012 18.7 16.0 3.7 3 1 0 3 3 3 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 EFC48772.1 - 0.01 15.7 19.5 0.01 15.7 19.5 3.9 3 2 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Lge1 PF11488.8 EFC48772.1 - 0.03 14.5 0.2 0.069 13.3 0.2 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 Acetyltransf_1 PF00583.25 EFC48774.1 - 2.7e-10 40.5 0.1 5.7e-10 39.5 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC48774.1 - 1.1e-07 31.8 0.0 2.5e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC48774.1 - 5.1e-06 26.8 0.9 2.1e-05 24.9 0.1 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC48774.1 - 1.3e-05 25.1 0.0 3.5e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 EFC48774.1 - 5.9e-05 23.1 0.1 0.00065 19.8 0.1 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 EFC48774.1 - 0.0041 16.7 0.0 0.0075 15.9 0.0 1.4 1 1 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_3 PF13302.7 EFC48774.1 - 0.0043 17.7 0.0 0.0087 16.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC48774.1 - 0.0074 15.8 0.2 0.014 14.8 0.2 1.4 1 0 0 1 1 1 1 Putative acetyl-transferase 2Fe-2S_thioredx PF01257.19 EFC48774.1 - 0.0086 15.9 0.2 0.5 10.2 0.1 2.2 1 1 1 2 2 2 2 Thioredoxin-like [2Fe-2S] ferredoxin CAP18_C PF12153.8 EFC48774.1 - 0.14 12.1 1.9 0.58 10.1 1.9 2.1 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) Mito_carr PF00153.27 EFC48775.1 - 5.3e-28 96.8 0.0 8.1e-19 67.3 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Abhydrolase_2 PF02230.16 EFC48776.1 - 2.2e-40 138.8 0.1 2.7e-40 138.5 0.1 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 EFC48776.1 - 1.2e-05 24.8 0.0 0.11 11.7 0.0 2.9 2 1 1 3 3 3 2 Serine aminopeptidase, S33 DLH PF01738.18 EFC48776.1 - 2.1e-05 24.2 0.0 2.4e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 EFC48776.1 - 0.0039 16.9 0.0 0.0061 16.2 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 EFC48776.1 - 0.0077 15.7 0.0 0.86 9.0 0.0 2.2 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 EFC48776.1 - 0.0091 15.8 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 EFC48776.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 1 0 1 1 1 0 Putative esterase BAAT_C PF08840.11 EFC48776.1 - 0.017 15.0 0.1 0.068 13.1 0.0 1.8 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase_phd PF10503.9 EFC48776.1 - 0.025 14.1 0.0 0.12 11.8 0.0 1.9 1 1 1 2 2 2 0 Esterase PHB depolymerase AXE1 PF05448.12 EFC48776.1 - 0.059 12.0 0.0 0.091 11.4 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Abhydrolase_3 PF07859.13 EFC48776.1 - 0.17 11.7 0.0 0.23 11.3 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC48776.1 - 0.27 11.8 0.0 1.1 9.8 0.0 1.8 1 1 0 2 2 2 0 Alpha/beta hydrolase family RabGAP-TBC PF00566.18 EFC48778.1 - 6.7e-50 169.7 4.3 3.1e-49 167.6 4.3 2.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain RhoGEF PF00621.20 EFC48778.1 - 5.4e-09 36.5 21.1 1.4e-08 35.2 6.8 4.6 5 0 0 5 5 5 2 RhoGEF domain Arm PF00514.23 EFC48778.1 - 9e-05 22.4 14.9 1.8 8.7 0.3 7.9 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat Ribonuclease_3 PF00636.26 EFC48778.1 - 0.12 13.0 1.1 11 6.7 0.1 3.1 2 0 0 2 2 2 0 Ribonuclease III domain RRM_1 PF00076.22 EFC48779.1 - 1.2e-32 111.5 0.2 1.2e-12 47.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC48779.1 - 2e-10 40.4 0.1 2e-05 24.4 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 EFC48779.1 - 5.1e-08 32.8 0.0 0.003 17.5 0.0 3.2 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 EFC48779.1 - 1e-06 28.4 1.9 0.00022 20.8 0.3 3.2 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NCBP3 PF10309.9 EFC48779.1 - 5.4e-05 23.0 0.1 0.49 10.3 0.0 3.3 2 1 0 2 2 2 2 Nuclear cap-binding protein subunit 3 RL PF17797.1 EFC48779.1 - 0.00039 20.3 1.4 0.013 15.4 0.0 3.2 3 1 0 3 3 3 1 RL domain Nup35_RRM PF05172.13 EFC48779.1 - 0.00043 20.2 0.1 0.01 15.8 0.1 2.6 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 EFC48779.1 - 0.003 17.4 0.0 1.2 8.9 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF1866) RRM_7 PF16367.5 EFC48779.1 - 0.0077 16.3 0.1 0.79 9.9 0.0 3.3 3 1 0 3 3 3 1 RNA recognition motif TMEM171 PF15471.6 EFC48779.1 - 0.15 11.0 1.9 0.28 10.1 1.9 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 GTP_EFTU PF00009.27 EFC48780.1 - 1.4e-58 197.6 0.7 2.1e-58 197.1 0.7 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC48780.1 - 8.3e-24 84.1 0.1 5.7e-23 81.4 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC48780.1 - 1.5e-15 57.3 1.3 3.8e-15 56.0 1.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 PduV-EutP PF10662.9 EFC48780.1 - 7.5e-05 22.5 0.2 1.5 8.5 0.1 3.4 3 0 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 EFC48780.1 - 0.00013 22.0 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 EFC48780.1 - 0.0024 17.5 0.2 0.0061 16.2 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 EFC48780.1 - 0.0025 17.7 0.1 0.01 15.8 0.0 1.8 1 1 1 2 2 2 1 RsgA GTPase GCN5L1 PF06320.13 EFC48781.1 - 2.5e-37 127.5 17.3 2.8e-37 127.4 17.3 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) Rota_NSP3 PF01665.16 EFC48781.1 - 0.0087 15.2 5.5 0.0093 15.1 5.5 1.0 1 0 0 1 1 1 1 Rotavirus non-structural protein NSP3 DUF677 PF05055.12 EFC48781.1 - 0.01 14.8 3.1 0.011 14.7 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF677) BLOC1_2 PF10046.9 EFC48781.1 - 0.014 15.7 1.3 0.014 15.7 1.3 1.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2009 PF09418.10 EFC48781.1 - 0.049 12.7 6.4 0.053 12.6 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) DUF489 PF04356.12 EFC48781.1 - 0.053 13.5 4.0 0.059 13.4 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF489) YscO-like PF16789.5 EFC48781.1 - 0.086 12.9 12.1 0.11 12.5 12.1 1.2 1 0 0 1 1 1 0 YscO-like protein Snapin_Pallidin PF14712.6 EFC48781.1 - 0.27 11.7 8.9 0.035 14.5 3.8 1.9 1 1 1 2 2 2 0 Snapin/Pallidin DUF4337 PF14235.6 EFC48781.1 - 0.27 11.3 6.3 0.4 10.8 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Sec2p PF06428.11 EFC48781.1 - 0.28 11.2 10.1 0.31 11.0 9.4 1.4 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p SRA PF18491.1 EFC48781.1 - 0.52 10.4 10.3 0.063 13.4 5.3 1.8 1 1 1 2 2 2 0 SET and RING associated domain DUF1664 PF07889.12 EFC48781.1 - 0.68 10.0 9.1 1.3 9.1 5.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ATP-synt_B PF00430.18 EFC48781.1 - 0.8 9.8 7.7 1.1 9.3 7.2 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) DUF883 PF05957.13 EFC48781.1 - 2.7 8.7 5.6 4.5 7.9 2.1 2.3 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) LMBR1 PF04791.16 EFC48781.1 - 2.8 6.7 11.1 3.1 6.6 11.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Fzo_mitofusin PF04799.13 EFC48781.1 - 3.1 7.3 9.5 11 5.5 9.5 1.8 1 1 0 1 1 1 0 fzo-like conserved region DUF948 PF06103.11 EFC48781.1 - 3.3 8.0 6.7 51 4.2 6.7 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) UCH_C PF18031.1 EFC48781.1 - 6 6.9 10.0 0.93 9.4 5.3 2.1 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolases AMP-binding PF00501.28 EFC48782.1 - 1.4e-99 333.6 0.3 2.1e-99 333.0 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme BBS2_Mid PF14783.6 EFC48782.1 - 0.0075 16.3 0.3 0.15 12.1 0.0 2.5 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region AMP-binding_C PF13193.6 EFC48782.1 - 0.024 15.6 0.1 0.13 13.3 0.0 2.4 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Ras PF00071.22 EFC48783.1 - 7.2e-59 198.0 3.8 8.4e-59 197.8 3.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48783.1 - 3.7e-32 111.1 1.1 4.6e-32 110.7 0.2 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48783.1 - 1.1e-19 70.6 0.8 1.5e-19 70.2 0.8 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC48783.1 - 2e-07 31.1 0.3 3.5e-07 30.3 0.1 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC48783.1 - 9.6e-06 25.3 0.5 1.6e-05 24.5 0.5 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC48783.1 - 2.1e-05 24.0 2.0 4.7e-05 22.9 0.3 1.9 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 EFC48783.1 - 0.0026 17.6 0.8 0.0039 17.0 0.4 1.4 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 EFC48783.1 - 0.0063 16.1 1.3 0.085 12.4 1.3 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC48783.1 - 0.0071 16.3 2.3 0.6 10.0 0.7 2.6 1 1 2 3 3 3 1 RsgA GTPase PRP8_domainIV PF12134.8 EFC48783.1 - 0.03 14.0 0.1 0.046 13.4 0.1 1.2 1 0 0 1 1 1 0 PRP8 domain IV core TniB PF05621.11 EFC48783.1 - 0.057 12.8 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein ApoL PF05461.11 EFC48784.1 - 1.3e-07 31.2 3.7 2.4e-07 30.4 3.7 1.5 1 1 0 1 1 1 1 Apolipoprotein L DUF1993 PF09351.10 EFC48784.1 - 0.08 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) adh_short PF00106.25 EFC48785.1 - 9.7e-23 80.6 0.2 2.2e-20 73.0 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC48785.1 - 6.4e-18 65.2 0.0 3.7e-16 59.4 0.0 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFC48785.1 - 8.3e-07 28.7 0.2 1.1e-06 28.4 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 EFC48785.1 - 2.1e-06 27.4 0.1 3e-06 26.9 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFC48785.1 - 0.00018 21.8 0.0 0.00076 19.7 0.0 2.0 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 EFC48785.1 - 0.025 14.5 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 KR domain EphA2_TM PF14575.6 EFC48786.1 - 0.69 10.8 3.4 2.9 8.8 1.4 2.6 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Cupin_8 PF13621.6 EFC48787.1 - 6.4e-30 104.7 0.1 1.1e-29 104.0 0.1 1.3 1 0 0 1 1 1 1 Cupin-like domain Kelch_4 PF13418.6 EFC48787.1 - 5.3e-26 90.4 2.2 3.2e-09 36.6 0.0 5.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC48787.1 - 2.2e-19 69.2 0.0 5.9e-08 32.8 0.0 4.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC48787.1 - 3.1e-19 68.5 3.8 2.7e-05 24.3 0.0 4.8 3 1 1 4 4 4 3 Kelch motif Kelch_5 PF13854.6 EFC48787.1 - 1.7e-14 53.4 3.5 9.9e-05 22.2 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 EFC48787.1 - 3.6e-13 48.9 1.5 4.5e-05 22.9 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 EFC48787.1 - 1.5e-08 34.3 4.2 0.00016 21.5 0.0 4.3 4 0 0 4 4 3 2 Kelch motif Cupin_4 PF08007.12 EFC48787.1 - 7.1e-08 32.3 0.2 3.4e-07 30.0 0.2 1.9 1 1 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 EFC48787.1 - 4.1e-05 24.0 0.2 0.00023 21.5 0.1 2.5 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_1 PF00190.22 EFC48787.1 - 0.00016 21.3 0.0 0.00042 20.0 0.0 1.7 1 0 0 1 1 1 1 Cupin Cupin_2 PF07883.11 EFC48787.1 - 0.067 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain Cupin_6 PF12852.7 EFC48787.1 - 0.13 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Cupin Ribul_P_3_epim PF00834.19 EFC48788.1 - 1.1e-64 217.4 0.6 1.4e-64 217.2 0.6 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family His_biosynth PF00977.21 EFC48788.1 - 0.015 14.8 0.1 0.044 13.3 0.0 1.8 2 1 0 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.14 EFC48788.1 - 0.037 13.3 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG QRPTase_C PF01729.19 EFC48788.1 - 0.086 12.6 0.1 0.25 11.1 0.0 1.7 2 1 1 3 3 3 0 Quinolinate phosphoribosyl transferase, C-terminal domain OMPdecase PF00215.24 EFC48788.1 - 0.13 11.8 0.3 0.58 9.7 0.3 2.2 1 1 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family DUF1765 PF08578.10 EFC48789.1 - 2.6e-30 105.4 10.0 4e-30 104.8 8.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) RlaP PF10127.9 EFC48789.1 - 4.4e-16 59.2 0.0 1.3e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 RNA repair pathway DNA polymerase beta family LRR_6 PF13516.6 EFC48791.1 - 2.1e-91 292.3 31.5 1.3e-05 24.8 0.1 18.1 18 0 0 18 18 18 18 Leucine Rich repeat LRR_8 PF13855.6 EFC48791.1 - 4.8e-57 189.6 36.0 1e-09 38.0 0.4 8.2 2 2 9 11 11 11 11 Leucine rich repeat LRR_4 PF12799.7 EFC48791.1 - 2e-51 171.1 20.0 6.6e-05 23.2 0.0 11.1 2 1 7 13 13 13 13 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48791.1 - 4.7e-37 120.8 0.0 4 8.4 0.0 18.1 19 0 0 19 19 19 5 Leucine Rich Repeat LRR_9 PF14580.6 EFC48791.1 - 4.4e-14 52.4 0.1 0.0023 17.5 0.0 4.5 1 1 2 4 4 4 4 Leucine-rich repeat CLU_N PF15044.6 EFC48791.1 - 3.1e-06 27.5 9.8 7.6 7.0 0.0 8.1 5 3 4 11 11 11 1 Mitochondrial function, CLU-N-term bZIP_C PF12498.8 EFC48791.1 - 0.097 13.7 9.3 18 6.4 0.2 5.4 2 1 2 6 6 6 0 Basic leucine-zipper C terminal ApoB100_C PF12491.8 EFC48791.1 - 0.13 12.2 17.4 9.8 6.2 0.0 9.8 8 5 6 14 14 14 0 Apolipoprotein B100 C terminal GAD PF02938.14 EFC48791.1 - 0.18 12.0 4.0 16 5.8 0.1 4.1 4 1 0 4 4 4 0 GAD domain Peptidase_M1 PF01433.20 EFC48792.1 - 9.7e-61 205.1 1.5 9.7e-61 205.1 1.5 1.8 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFC48792.1 - 1.7e-60 205.2 0.7 7.9e-60 203.0 0.3 2.0 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFC48792.1 - 1.2e-35 123.4 3.1 1.9e-35 122.8 1.3 2.3 2 1 0 2 2 2 1 Peptidase M1 N-terminal domain Cys_Met_Meta_PP PF01053.20 EFC48793.1 - 3.5e-57 193.7 0.0 3.2e-56 190.5 0.0 1.9 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 EFC48793.1 - 0.00039 19.5 0.0 0.014 14.3 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-V Aminotran_1_2 PF00155.21 EFC48793.1 - 0.077 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Ephrin_rec_like PF07699.13 EFC48796.1 - 0.00032 20.4 9.7 0.00065 19.4 1.4 2.4 1 1 1 2 2 2 2 Putative ephrin-receptor like Lipocalin_4 PF13648.6 EFC48796.1 - 0.79 10.7 5.9 0.75 10.8 0.2 2.8 2 1 0 2 2 2 0 Lipocalin-like domain TNFR_c6 PF00020.18 EFC48796.1 - 0.84 10.1 7.7 0.24 11.8 2.5 2.4 1 1 1 2 2 2 0 TNFR/NGFR cysteine-rich region NCD3G PF07562.14 EFC48796.1 - 8.2 6.5 9.9 6.4 6.8 1.4 2.4 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR SapB_2 PF03489.17 EFC48797.1 - 0.033 14.3 0.1 7.6 6.7 0.0 2.8 2 0 0 2 2 2 0 Saposin-like type B, region 2 Metallophos_2 PF12850.7 EFC48799.1 - 0.0024 18.1 3.0 0.028 14.6 0.0 2.6 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 EFC48799.1 - 0.0027 18.2 0.2 0.0027 18.2 0.2 2.2 2 1 1 3 3 3 1 Calcineurin-like phosphoesterase RbpA PF13397.6 EFC48799.1 - 0.05 14.2 0.6 3.2 8.4 0.1 2.6 2 0 0 2 2 2 0 RNA polymerase-binding protein DUF4116 PF13475.6 EFC48800.1 - 2.4e-49 164.8 45.0 1.3e-14 53.7 2.7 6.6 2 2 4 7 7 7 6 Domain of unknown function (DUF4116) DUF447 PF04289.12 EFC48800.1 - 0.2 11.4 2.1 7 6.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF447) UPF0184 PF03670.13 EFC48800.1 - 1.1 9.7 6.0 1.3 9.5 0.1 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0184) Shisa PF13908.6 EFC48801.1 - 0.01 16.1 0.2 0.014 15.6 0.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF3244 PF11589.8 EFC48801.1 - 0.049 13.7 2.6 0.099 12.7 2.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) PPC PF04151.15 EFC48801.1 - 0.071 14.2 4.5 0.13 13.4 4.5 1.4 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain EphA2_TM PF14575.6 EFC48801.1 - 0.14 13.1 0.2 0.23 12.3 0.2 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain HSP70 PF00012.20 EFC48802.1 - 1.4e-12 46.6 0.0 6.1e-12 44.5 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein EppA_BapA PF07268.11 EFC48802.1 - 0.058 13.3 0.6 4 7.4 0.1 2.6 2 0 0 2 2 2 0 Exported protein precursor (EppA/BapA) G8 PF10162.9 EFC48803.1 - 5.1e-15 55.6 0.0 1.3e-14 54.3 0.0 1.6 1 0 0 1 1 1 1 G8 domain CHRD PF07452.12 EFC48803.1 - 0.00033 21.6 0.1 0.0011 19.9 0.0 1.9 2 0 0 2 2 2 1 CHRD domain ARL6IP6 PF15062.6 EFC48803.1 - 0.076 13.2 0.2 0.56 10.4 0.0 2.4 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix F-box-like PF12937.7 EFC48804.1 - 5.3e-05 23.0 0.0 0.0001 22.1 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48804.1 - 0.0085 16.0 0.1 0.021 14.7 0.1 1.6 1 0 0 1 1 1 1 F-box domain Sporozoite_P67 PF05642.11 EFC48804.1 - 2 6.4 9.5 3.2 5.7 9.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen F-box-like PF12937.7 EFC48805.1 - 4.7e-05 23.2 0.0 0.00013 21.8 0.0 1.7 1 0 0 1 1 1 1 F-box-like RNA_pol_3_Rpc31 PF11705.8 EFC48805.1 - 0.013 15.8 10.9 0.022 15.0 10.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 EFC48805.1 - 0.32 11.0 6.0 0.49 10.4 4.3 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF3073 PF11273.8 EFC48805.1 - 2.2 9.1 9.7 13 6.6 9.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3073) NOA36 PF06524.12 EFC48805.1 - 7 5.9 12.4 11 5.2 12.4 1.2 1 0 0 1 1 1 0 NOA36 protein Tat PF00539.18 EFC48806.1 - 0.024 14.8 0.9 0.38 10.9 0.7 2.2 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) CAP PF00188.26 EFC48807.1 - 3.6e-16 60.2 1.7 5.2e-16 59.6 1.7 1.2 1 0 0 1 1 1 1 Cysteine-rich secretory protein family MAGP PF05507.11 EFC48807.1 - 0.18 12.2 1.2 0.24 11.8 0.0 1.8 2 1 0 2 2 2 0 Microfibril-associated glycoprotein (MAGP) DUF5082 PF16888.5 EFC48808.1 - 0.014 15.7 4.1 2.5 8.4 0.0 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) YtxH PF12732.7 EFC48808.1 - 0.024 15.2 13.2 0.45 11.1 0.3 4.3 3 2 0 3 3 3 0 YtxH-like protein FeoB_Cyto PF17910.1 EFC48808.1 - 0.046 14.3 1.4 1.9 9.1 0.0 3.2 2 1 1 3 3 3 0 FeoB cytosolic helical domain Protoglobin PF11563.8 EFC48808.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Protoglobin EzrA PF06160.12 EFC48808.1 - 0.6 8.2 6.5 0.31 9.2 0.0 2.6 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA EF-G-binding_N PF07299.11 EFC48808.1 - 2.5 8.7 5.6 1.7 9.2 0.2 3.3 5 0 0 5 5 5 0 Elongation factor G-binding protein, N-terminal NPA PF16469.5 EFC48808.1 - 4.3 7.9 9.3 0.68 10.5 2.5 2.6 2 1 0 2 2 2 0 Nematode polyprotein allergen ABA-1 DUF4116 PF13475.6 EFC48810.1 - 7.3e-33 112.1 1.9 6.7e-19 67.4 0.1 3.6 2 1 1 3 3 3 3 Domain of unknown function (DUF4116) Phosphodiest PF01663.22 EFC48812.1 - 2.5e-68 231.3 1.1 3e-68 231.0 1.1 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 EFC48812.1 - 4.3e-07 29.6 0.1 1.5e-05 24.5 0.1 2.5 1 1 0 1 1 1 1 Sulfatase Sre PF03125.18 EFC48812.1 - 0.049 12.8 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor WSN PF02206.18 EFC48812.1 - 0.14 12.0 0.4 0.31 11.0 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function Gar1 PF04410.14 EFC48813.1 - 6.3e-16 58.5 0.0 8.4e-16 58.1 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region DIM1 PF02966.16 EFC48814.1 - 0.0011 18.7 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 EFC48814.1 - 0.0029 17.6 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin EGF_2 PF07974.13 EFC48815.1 - 1.1e-34 118.5 112.0 2.7e-06 27.6 8.4 8.6 7 1 1 8 8 8 8 EGF-like domain EGF PF00008.27 EFC48815.1 - 0.00022 21.4 97.6 0.02 15.2 5.0 10.1 7 2 2 9 9 9 7 EGF-like domain EGF_Tenascin PF18720.1 EFC48815.1 - 0.0015 18.5 5.5 0.0015 18.5 5.5 8.9 8 1 1 9 9 9 5 Tenascin EGF domain hEGF PF12661.7 EFC48815.1 - 0.036 14.7 7.1 0.036 14.7 7.1 10.6 9 1 0 9 9 9 0 Human growth factor-like EGF Laminin_EGF PF00053.24 EFC48815.1 - 0.65 10.2 105.2 0.21 11.8 10.4 8.4 1 1 7 8 8 8 0 Laminin EGF domain SNF PF00209.18 EFC48816.1 - 3.5e-81 273.5 46.5 7.3e-73 246.0 33.6 3.7 3 1 0 3 3 3 2 Sodium:neurotransmitter symporter family AIG2_2 PF13772.6 EFC48817.1 - 0.022 15.1 0.0 0.14 12.5 0.0 2.0 2 0 0 2 2 2 0 AIG2-like family GGACT PF06094.12 EFC48817.1 - 0.026 15.1 0.0 0.039 14.6 0.0 1.3 1 0 0 1 1 1 0 Gamma-glutamyl cyclotransferase, AIG2-like LrgA PF03788.14 EFC48817.1 - 0.087 12.8 0.2 0.14 12.1 0.2 1.3 1 0 0 1 1 1 0 LrgA family Aminotran_1_2 PF00155.21 EFC48818.1 - 8.4e-42 143.6 0.0 2.4e-41 142.1 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II Ras PF00071.22 EFC48819.1 - 1e-48 165.0 1.3 1.2e-48 164.8 1.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48819.1 - 2.1e-17 63.4 0.1 7.5e-17 61.7 0.1 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48819.1 - 1e-11 44.6 0.2 1.3e-11 44.3 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC48819.1 - 2.1e-06 27.7 2.2 0.016 15.1 0.1 2.3 1 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EFC48819.1 - 5.1e-06 25.9 0.6 6.6e-06 25.5 0.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC48819.1 - 0.00062 19.8 0.1 0.0011 19.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC48819.1 - 0.001 18.6 0.1 0.0036 16.9 0.0 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DAP3 PF10236.9 EFC48819.1 - 0.01 15.0 1.0 0.014 14.6 0.3 1.5 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 EFC48819.1 - 0.02 14.1 1.9 0.04 13.1 0.9 2.1 1 1 1 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 EFC48819.1 - 0.041 13.8 4.0 0.41 10.5 4.0 2.1 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFC48819.1 - 0.064 13.5 0.0 0.2 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain Meckelin PF09773.9 EFC48821.1 - 1.8e-157 525.9 17.7 1.6e-156 522.7 17.7 2.0 1 1 0 1 1 1 1 Meckelin (Transmembrane protein 67) TauE PF01925.19 EFC48821.1 - 1 8.9 5.6 0.1 12.2 1.0 1.6 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE cEGF PF12662.7 EFC48821.1 - 3.7 7.6 8.9 0.88 9.6 3.0 2.6 2 0 0 2 2 2 0 Complement Clr-like EGF-like Myosin_head PF00063.21 EFC48823.1 - 4.2e-212 706.1 12.6 1.2e-211 704.6 12.6 1.7 1 1 0 1 1 1 1 Myosin head (motor domain) AAA_16 PF13191.6 EFC48823.1 - 0.015 15.7 1.3 0.15 12.4 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_6 PF12774.7 EFC48823.1 - 0.019 14.0 0.4 0.57 9.1 0.1 2.6 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region AAA_22 PF13401.6 EFC48823.1 - 0.084 13.1 0.0 0.084 13.1 0.0 3.2 2 1 0 2 2 2 0 AAA domain Glyco_hydro_77 PF02446.17 EFC48823.1 - 0.23 10.3 0.0 0.23 10.3 0.0 2.0 2 0 0 2 2 2 0 4-alpha-glucanotransferase Terminase_3C PF17288.2 EFC48823.1 - 6.2 7.2 14.4 15 5.9 9.9 3.2 1 1 2 3 3 3 0 Terminase RNAseH like domain Asn_synthase PF00733.21 EFC48824.1 - 8.8e-07 28.9 0.8 1.8e-05 24.6 0.8 2.2 1 1 0 1 1 1 1 Asparagine synthase Paramyxo_PNT PF14320.6 EFC48824.1 - 0.12 11.6 1.4 0.17 11.0 1.4 1.2 1 0 0 1 1 1 0 Phosphoprotein P region PNT disordered UFD1 PF03152.14 EFC48825.1 - 3e-68 228.7 0.0 3.8e-68 228.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 ChapFlgA PF13144.6 EFC48825.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Chaperone for flagella basal body P-ring formation ORC6 PF05460.13 EFC48825.1 - 1.2 8.4 10.8 1.6 7.9 10.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) LRR_4 PF12799.7 EFC48826.1 - 1e-07 32.1 42.3 0.036 14.5 0.1 9.0 4 3 5 10 10 10 6 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC48826.1 - 1.9e-07 30.6 25.8 0.2 11.8 0.5 8.1 9 0 0 9 9 9 4 Leucine Rich repeat LRR_8 PF13855.6 EFC48826.1 - 0.064 13.0 0.4 0.064 13.0 0.4 6.8 6 1 2 8 8 8 0 Leucine rich repeat LRR_1 PF00560.33 EFC48826.1 - 1.2 9.9 18.4 18 6.4 0.1 7.8 7 1 0 7 7 7 0 Leucine Rich Repeat Hydrolase_like PF13242.6 EFC48827.1 - 2.7e-18 65.8 0.0 5.1e-18 64.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 EFC48827.1 - 2.9e-12 46.6 0.0 1.1e-11 44.7 0.0 1.9 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 EFC48827.1 - 0.0052 16.4 0.0 0.021 14.4 0.0 1.8 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase HTH_Tnp_Mu_2 PF09039.11 EFC48827.1 - 0.17 12.0 0.0 0.33 11.0 0.0 1.4 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain Toprim_4 PF13662.6 EFC48827.1 - 0.17 12.3 0.0 0.42 11.1 0.0 1.6 1 0 0 1 1 1 0 Toprim domain CactinC_cactus PF09732.9 EFC48828.1 - 8.3e-56 187.3 6.8 8.3e-56 187.3 6.8 1.9 2 0 0 2 2 2 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 EFC48828.1 - 9.1e-48 162.6 15.0 2.2e-47 161.4 15.0 1.7 1 0 0 1 1 1 1 Conserved mid region of cactin Glyco_hydro_39 PF01229.17 EFC48829.1 - 2.9e-102 342.8 4.7 8.3e-102 341.3 4.7 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 39 Cellulase PF00150.18 EFC48829.1 - 0.0038 16.7 0.4 0.0069 15.8 0.4 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) MCM PF00493.23 EFC48830.1 - 6e-89 297.0 0.0 9.2e-89 296.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC48830.1 - 4.6e-29 100.8 1.6 9.4e-29 99.8 1.6 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFC48830.1 - 2e-27 95.4 3.0 4.9e-27 94.2 3.0 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 EFC48830.1 - 1.5e-08 34.3 0.1 1.8e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 EFC48830.1 - 5.7e-08 32.9 0.0 1.2e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 EFC48830.1 - 7.1e-05 22.7 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 EFC48830.1 - 0.004 16.9 0.0 0.02 14.6 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 EFC48830.1 - 0.0057 17.1 0.5 0.038 14.4 0.1 2.4 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 EFC48830.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC48830.1 - 0.11 12.7 0.2 1.4 9.2 0.2 2.7 1 1 0 1 1 1 0 AAA domain Bromodomain PF00439.25 EFC48831.1 - 1.3e-15 57.3 1.6 1.3e-15 57.3 1.6 2.1 2 0 0 2 2 2 1 Bromodomain MnmE_helical PF12631.7 EFC48832.1 - 8.9e-40 137.1 1.8 2.5e-39 135.6 1.8 1.7 1 1 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 EFC48832.1 - 1.6e-35 121.9 0.0 5.3e-35 120.2 0.0 2.0 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 EFC48832.1 - 5.1e-23 81.3 0.1 1.3e-22 80.0 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC48832.1 - 1.3e-07 31.3 0.1 3.8e-07 29.8 0.1 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 EFC48832.1 - 5.9e-07 29.7 0.2 1.9e-05 24.8 0.0 2.6 1 1 1 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 EFC48832.1 - 0.0012 18.8 0.6 0.19 11.6 0.0 3.1 3 0 0 3 3 3 1 RsgA GTPase Ras PF00071.22 EFC48832.1 - 0.0034 17.0 0.1 3.3 7.3 0.0 2.5 2 0 0 2 2 2 2 Ras family Arf PF00025.21 EFC48832.1 - 0.004 16.6 0.9 0.4 10.1 0.0 2.7 2 1 0 2 2 2 1 ADP-ribosylation factor family AAA_24 PF13479.6 EFC48832.1 - 0.0069 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFC48832.1 - 0.018 15.3 0.0 0.079 13.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.16 EFC48832.1 - 0.021 14.2 0.0 0.056 12.8 0.0 1.8 1 0 0 1 1 1 0 AIG1 family DUF1890 PF09001.11 EFC48832.1 - 0.045 14.1 1.1 1.6 9.1 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1890) hnRNP_Q_AcD PF18360.1 EFC48832.1 - 0.059 13.3 0.0 0.18 11.8 0.0 1.9 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain ABC_tran PF00005.27 EFC48832.1 - 0.12 12.9 0.9 0.32 11.5 0.9 1.9 1 1 0 1 1 1 0 ABC transporter Prp31_C PF09785.9 EFC48832.1 - 0.12 13.3 0.0 0.28 12.1 0.0 1.6 1 0 0 1 1 1 0 Prp31 C terminal domain E1-E2_ATPase PF00122.20 EFC48833.1 - 5.1e-42 143.4 1.3 5.1e-42 143.4 1.3 2.7 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFC48833.1 - 4e-22 78.8 8.0 4e-22 78.8 8.0 3.0 4 0 0 4 4 4 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFC48833.1 - 3.1e-17 63.6 0.0 1.2e-16 61.7 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFC48833.1 - 3.8e-17 61.7 0.1 1.1e-16 60.3 0.1 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 EFC48833.1 - 9.8e-13 48.0 0.1 2.6e-12 46.6 0.1 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC48833.1 - 0.001 18.8 6.2 0.0031 17.3 0.6 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Aldolase PF01081.19 EFC48833.1 - 0.023 14.1 0.0 0.099 12.1 0.0 2.1 1 0 0 1 1 1 0 KDPG and KHG aldolase Smr PF01713.21 EFC48834.1 - 3.8e-11 43.2 0.1 7e-11 42.3 0.1 1.5 1 0 0 1 1 1 1 Smr domain NPR3 PF03666.13 EFC48834.1 - 0.039 12.8 9.2 0.061 12.1 9.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4175 PF13779.6 EFC48834.1 - 2 6.3 12.1 2.6 5.8 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ndc1_Nup PF09531.10 EFC48834.1 - 6 5.4 7.2 7.9 5.0 7.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 EFC48834.1 - 7.2 5.3 15.0 10 4.8 15.0 1.2 1 0 0 1 1 1 0 Presenilin Mitofilin PF09731.9 EFC48834.1 - 9.1 5.0 20.2 8 5.2 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein DUF3861 PF12977.7 EFC48835.1 - 0.024 14.8 0.5 1.5 9.0 0.1 2.5 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3861) AntA PF08346.12 EFC48835.1 - 0.23 12.1 1.6 0.46 11.1 0.5 2.0 2 0 0 2 2 2 0 AntA/AntB antirepressor SLAC1 PF03595.17 EFC48836.1 - 0.0016 17.8 1.6 0.0016 17.8 1.6 1.5 2 0 0 2 2 2 1 Voltage-dependent anion channel DUF4834 PF16118.5 EFC48836.1 - 1.6 9.7 8.3 0.58 11.1 1.6 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Glycoprotein_G PF00802.19 EFC48836.1 - 5.6 6.3 12.4 0.75 9.1 7.1 2.0 1 1 0 1 1 1 0 Pneumovirus attachment glycoprotein G DUF4241 PF14025.6 EFC48838.1 - 3.6e-34 118.7 0.1 6.8e-34 117.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4241) DUF1652 PF07865.11 EFC48838.1 - 0.042 13.7 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1652) Y_phosphatase PF00102.27 EFC48839.1 - 2.3e-62 210.7 0.3 3.3e-62 210.1 0.3 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFC48839.1 - 6.1e-06 26.1 0.2 6.3e-05 22.8 0.0 2.7 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC48839.1 - 0.039 14.1 0.0 0.16 12.1 0.0 2.1 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 EFC48839.1 - 0.07 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Ank_4 PF13637.6 EFC48840.1 - 7e-16 58.4 2.0 6.5e-11 42.5 0.5 3.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC48840.1 - 1.7e-14 54.2 0.6 5e-06 27.0 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC48840.1 - 7.4e-13 48.4 0.3 5.1e-05 23.5 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC48840.1 - 5.6e-11 42.4 0.6 0.00039 20.7 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFC48840.1 - 1.9e-10 40.0 1.5 0.0027 18.1 0.0 4.0 5 0 0 5 5 5 2 Ankyrin repeat F-box-like PF12937.7 EFC48841.1 - 0.0066 16.3 0.0 0.016 15.1 0.0 1.7 1 0 0 1 1 1 1 F-box-like SE PF08491.10 EFC48842.1 - 5.4e-68 229.0 0.0 4.6e-52 176.8 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase DAO PF01266.24 EFC48842.1 - 2.5e-15 56.9 0.3 2.2e-08 34.1 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 EFC48842.1 - 3.3e-13 49.6 0.0 6.8e-13 48.6 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 EFC48842.1 - 4.5e-05 23.6 0.7 0.0001 22.5 0.7 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 EFC48842.1 - 0.00011 21.2 1.2 0.76 8.6 0.1 3.1 3 0 0 3 3 3 2 Tryptophan halogenase Pyr_redox PF00070.27 EFC48842.1 - 0.00014 22.3 0.2 0.0049 17.4 0.3 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 EFC48842.1 - 0.00017 20.9 0.3 0.0026 17.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 EFC48842.1 - 0.00029 20.0 2.3 0.0007 18.8 1.6 1.8 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 EFC48842.1 - 0.0012 18.0 4.3 0.66 9.0 4.2 3.1 2 1 0 2 2 2 1 Lycopene cyclase protein GDI PF00996.18 EFC48842.1 - 0.002 16.8 0.1 0.0033 16.0 0.1 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor GMC_oxred_N PF00732.19 EFC48842.1 - 0.0038 16.6 0.1 0.73 9.1 0.0 2.3 2 0 0 2 2 2 1 GMC oxidoreductase FAD_oxidored PF12831.7 EFC48842.1 - 0.0093 15.4 2.2 0.02 14.3 2.2 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Flp_Fap PF04964.14 EFC48842.1 - 0.0099 15.7 0.5 0.036 13.9 0.5 2.0 1 0 0 1 1 1 1 Flp/Fap pilin component Thi4 PF01946.17 EFC48842.1 - 0.077 12.2 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 EFC48842.1 - 0.092 12.0 0.7 0.18 11.0 0.7 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 EFC48842.1 - 0.1 11.3 0.7 0.71 8.5 0.3 2.1 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 EFC48842.1 - 0.11 11.6 2.6 0.32 10.0 2.6 1.8 1 1 0 1 1 1 0 Glucose inhibited division protein A SE PF08491.10 EFC48843.1 - 1e-58 198.6 0.0 1.6e-53 181.6 0.1 2.7 1 1 1 2 2 2 2 Squalene epoxidase FAD_binding_3 PF01494.19 EFC48843.1 - 9e-19 67.9 0.0 1.5e-18 67.2 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 EFC48843.1 - 4.9e-15 56.0 0.2 5.6e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC48843.1 - 2.7e-05 24.3 0.7 8.2e-05 22.8 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFC48843.1 - 3.3e-05 23.2 1.2 0.00057 19.1 1.6 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC48843.1 - 0.00014 21.2 1.3 0.0016 17.7 1.4 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 EFC48843.1 - 0.00016 20.9 0.4 0.021 13.9 0.7 2.8 2 1 0 2 2 2 1 Lycopene cyclase protein Trp_halogenase PF04820.14 EFC48843.1 - 0.00017 20.5 0.4 2.3 7.0 0.0 3.0 3 0 0 3 3 3 2 Tryptophan halogenase Pyr_redox PF00070.27 EFC48843.1 - 0.00025 21.5 1.4 0.004 17.7 0.3 3.2 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 EFC48843.1 - 0.0012 18.3 0.1 0.27 10.6 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase GDI PF00996.18 EFC48843.1 - 0.0016 17.1 0.1 0.0026 16.3 0.1 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor FAD_oxidored PF12831.7 EFC48843.1 - 0.0032 16.9 2.1 0.011 15.1 2.1 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 EFC48843.1 - 0.05 12.3 0.3 0.56 8.9 0.2 2.3 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 EFC48843.1 - 0.076 12.1 0.9 0.11 11.5 0.9 1.4 1 1 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 EFC48843.1 - 0.078 12.2 0.7 0.15 11.3 0.7 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFC48843.1 - 0.082 12.1 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 Thi4 family ApbA PF02558.16 EFC48843.1 - 0.15 11.7 0.1 0.43 10.2 0.1 1.8 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Oxidored_q6 PF01058.22 EFC48844.1 - 2.3e-18 66.3 0.0 3e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit DUF1317 PF07026.11 EFC48844.1 - 0.088 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1317) Arf PF00025.21 EFC48845.1 - 2.1e-40 138.0 0.0 2.6e-40 137.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC48845.1 - 9.3e-13 48.1 0.0 1.3e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC48845.1 - 1.8e-12 47.1 1.2 5.9e-08 32.2 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 EFC48845.1 - 1.3e-08 35.1 0.0 2.3e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC48845.1 - 1.7e-08 34.1 0.0 2.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 EFC48845.1 - 4.8e-06 26.9 0.0 8.4e-06 26.1 0.0 1.3 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC48845.1 - 2.5e-05 24.3 0.1 0.0075 16.2 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 EFC48845.1 - 2.6e-05 23.8 0.0 0.017 14.7 0.0 2.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC48845.1 - 6.8e-05 22.9 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC48845.1 - 8.4e-05 22.5 0.0 0.29 10.9 0.0 2.1 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein Septin PF00735.18 EFC48845.1 - 0.00083 18.7 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Septin NACHT PF05729.12 EFC48845.1 - 0.001 19.0 0.1 0.018 14.9 0.1 2.1 1 1 0 1 1 1 1 NACHT domain Gtr1_RagA PF04670.12 EFC48845.1 - 0.0035 16.7 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EFC48845.1 - 0.0044 17.4 0.0 0.0074 16.7 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 EFC48845.1 - 0.0046 17.1 0.1 0.026 14.7 0.0 2.1 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EFC48845.1 - 0.0052 16.2 0.0 0.069 12.5 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family ABC_tran PF00005.27 EFC48845.1 - 0.01 16.3 0.1 0.012 16.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter cobW PF02492.19 EFC48845.1 - 0.011 15.4 0.2 0.089 12.4 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 EFC48845.1 - 0.011 16.3 0.1 0.021 15.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 EFC48845.1 - 0.018 14.1 0.1 0.03 13.4 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 EFC48845.1 - 0.019 14.7 0.1 0.047 13.4 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MeaB PF03308.16 EFC48845.1 - 0.027 13.5 0.4 4.9 6.0 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB PduV-EutP PF10662.9 EFC48845.1 - 0.15 11.8 0.3 23 4.7 0.0 2.3 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 EFC48845.1 - 0.18 12.0 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain CutC PF03932.14 EFC48846.1 - 3.4e-32 111.6 1.6 1.9e-31 109.2 1.6 2.1 1 1 0 1 1 1 1 CutC family RNA_lig_T4_1 PF09511.10 EFC48846.1 - 0.0076 16.1 0.1 0.024 14.5 0.1 1.8 2 0 0 2 2 2 1 RNA ligase CooC_C PF15976.5 EFC48846.1 - 0.0094 16.0 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 1 CS1-pili formation C-terminal RNA_pol_Rpb2_2 PF04561.14 EFC48846.1 - 0.087 12.4 1.1 0.52 9.9 0.3 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 2 Saccharop_dh_N PF04455.12 EFC48846.1 - 0.11 13.0 1.4 0.54 10.7 0.1 2.6 3 1 1 4 4 4 0 LOR/SDH bifunctional enzyme conserved region IBD PF10416.9 EFC48846.1 - 0.21 11.6 2.3 1.1 9.2 0.3 2.2 2 0 0 2 2 2 0 Transcription-initiator DNA-binding domain IBD MRJP PF03022.16 EFC48847.1 - 4.2e-20 72.3 0.1 2.4e-18 66.5 0.1 2.8 1 1 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 EFC48847.1 - 0.00017 21.3 0.2 0.61 9.6 0.0 3.4 3 1 1 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region DUF4064 PF13273.6 EFC48847.1 - 0.16 12.2 2.2 12 6.2 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Ras PF00071.22 EFC48848.1 - 1.2e-23 83.5 0.2 1.3e-23 83.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48848.1 - 1.7e-09 37.9 0.0 2.9e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 EFC48848.1 - 1.2e-08 35.1 2.6 0.0013 18.6 0.3 2.1 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC48848.1 - 2.4e-07 30.8 0.0 3.8e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC48848.1 - 2.8e-05 24.4 0.1 8.3e-05 22.9 0.0 1.9 1 1 1 2 2 2 1 AAA domain FeoB_N PF02421.18 EFC48848.1 - 5.7e-05 22.7 0.1 0.00012 21.7 0.1 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 EFC48848.1 - 0.001 19.5 0.1 0.0016 18.9 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 EFC48848.1 - 0.0095 15.7 0.1 0.016 15.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 EFC48848.1 - 0.013 15.0 0.2 0.31 10.5 0.2 2.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Septin PF00735.18 EFC48848.1 - 0.025 13.9 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 Septin TniB PF05621.11 EFC48848.1 - 0.029 13.8 0.0 0.057 12.8 0.0 1.5 1 1 0 1 1 1 0 Bacterial TniB protein DUF4085 PF13315.6 EFC48848.1 - 0.033 13.8 0.1 0.058 13.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) CbiA PF01656.23 EFC48848.1 - 0.041 14.0 1.7 0.39 10.8 1.7 2.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Say1_Mug180 PF10340.9 EFC48848.1 - 0.049 12.5 0.1 0.058 12.2 0.1 1.1 1 0 0 1 1 1 0 Steryl acetyl hydrolase RNA_helicase PF00910.22 EFC48848.1 - 0.05 14.0 0.1 0.14 12.5 0.1 1.8 1 1 1 2 2 2 0 RNA helicase Viral_helicase1 PF01443.18 EFC48848.1 - 0.081 12.6 0.0 0.099 12.4 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Arf PF00025.21 EFC48848.1 - 0.12 11.9 0.2 0.22 10.9 0.1 1.5 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_7 PF12775.7 EFC48848.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 EFC48848.1 - 0.15 12.0 3.1 0.5 10.2 3.1 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EFC48848.1 - 0.15 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFC48848.1 - 0.19 12.2 0.7 0.57 10.7 0.7 1.9 1 1 0 1 1 1 0 ABC transporter DUF4932 PF16286.5 EFC48849.1 - 0.011 15.0 2.6 0.012 14.9 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4932) Peptidase_S9_N PF02897.15 EFC48850.1 - 4.8e-113 378.1 7.8 5.9e-113 377.8 7.8 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 EFC48850.1 - 1.8e-54 184.4 0.0 3.1e-54 183.7 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 EFC48850.1 - 0.022 14.6 0.1 0.086 12.7 0.1 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold RGS PF00615.19 EFC48851.1 - 0.00043 20.5 6.0 0.00043 20.5 6.0 2.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain CitMHS PF03600.16 EFC48851.1 - 0.011 14.9 0.1 1.9 7.6 0.0 2.1 2 0 0 2 2 2 0 Citrate transporter Guanylin PF02058.15 EFC48851.1 - 0.17 12.4 1.2 0.55 10.8 0.3 2.3 2 0 0 2 2 2 0 Guanylin precursor Sec23_helical PF04815.15 EFC48852.1 - 0.082 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Sec23/Sec24 helical domain zf-RING_2 PF13639.6 EFC48853.1 - 8.5e-12 45.2 4.8 1.3e-11 44.6 4.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 EFC48853.1 - 4.8e-09 35.8 2.9 8.5e-09 35.0 2.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 EFC48853.1 - 3.6e-08 33.6 3.7 7.6e-08 32.5 3.7 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 EFC48853.1 - 3.4e-07 30.0 5.8 5.3e-07 29.4 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC48853.1 - 2e-06 27.6 5.2 3.3e-06 26.9 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 EFC48853.1 - 1.8e-05 24.6 3.7 2.9e-05 24.0 3.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 EFC48853.1 - 8e-05 22.4 4.1 0.00012 21.8 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 EFC48853.1 - 0.00011 21.8 3.3 0.00017 21.2 3.3 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 EFC48853.1 - 0.00011 22.1 2.5 0.00022 21.2 2.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger PHD PF00628.29 EFC48853.1 - 0.00015 21.6 4.1 0.00027 20.7 4.1 1.4 1 0 0 1 1 1 1 PHD-finger zf-ANAPC11 PF12861.7 EFC48853.1 - 0.00024 21.1 0.8 0.00041 20.3 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 EFC48853.1 - 0.00075 19.8 3.7 0.0012 19.1 3.7 1.4 1 0 0 1 1 1 1 RING-like domain Prok-RING_4 PF14447.6 EFC48853.1 - 0.0041 16.9 4.5 0.009 15.8 4.5 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-HC5HC2H PF13771.6 EFC48853.1 - 0.0077 16.5 0.1 0.018 15.3 0.1 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain FANCL_C PF11793.8 EFC48853.1 - 0.018 15.2 5.7 0.088 13.0 5.7 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 EFC48853.1 - 0.045 13.9 3.8 0.079 13.1 3.8 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-HC5HC2H_2 PF13832.6 EFC48853.1 - 0.052 13.7 0.8 0.089 13.0 0.8 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-C3H2C3 PF17122.5 EFC48853.1 - 0.084 12.9 5.0 0.24 11.5 5.0 1.8 1 1 0 1 1 1 0 Zinc-finger zf-RING_10 PF16685.5 EFC48853.1 - 0.18 12.0 5.0 0.27 11.4 5.0 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 RINGv PF12906.7 EFC48853.1 - 0.19 11.8 4.8 0.38 10.9 4.8 1.5 1 0 0 1 1 1 0 RING-variant domain PPP4R2 PF09184.11 EFC48853.1 - 0.5 9.9 12.3 0.89 9.1 12.3 1.3 1 0 0 1 1 1 0 PPP4R2 C1_2 PF03107.16 EFC48853.1 - 0.55 10.6 3.0 0.75 10.2 0.5 2.1 2 0 0 2 2 2 0 C1 domain zf-RING_4 PF14570.6 EFC48853.1 - 0.63 9.9 3.5 1.3 8.9 3.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DNA_pol_phi PF04931.13 EFC48853.1 - 0.98 7.4 5.1 1.3 7.0 5.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFIIA PF03153.13 EFC48853.1 - 1.2 9.1 11.5 2.1 8.3 11.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ATAD4 PF15321.6 EFC48853.1 - 3.3 9.1 9.2 0.19 13.1 1.6 2.4 2 1 0 2 2 2 0 ATPase family AAA domain containing 4 Y_phosphatase PF00102.27 EFC48854.1 - 7.8e-56 189.3 0.2 1e-55 188.9 0.2 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFC48854.1 - 8.1e-07 28.9 0.0 1.7e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 EFC48854.1 - 0.0011 19.1 0.0 0.0025 17.9 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 EFC48854.1 - 0.016 14.9 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EFC48854.1 - 0.044 13.7 0.0 0.058 13.4 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Enolase_C PF00113.22 EFC48854.1 - 0.064 12.5 0.0 0.17 11.1 0.0 1.6 2 0 0 2 2 2 0 Enolase, C-terminal TIM barrel domain Lsm_C PF14894.6 EFC48854.1 - 0.091 12.6 0.0 0.33 10.8 0.0 2.1 1 0 0 1 1 1 0 Lsm C-terminal DUF773 PF05600.12 EFC48855.1 - 8.6e-138 460.2 27.5 1.2e-137 459.8 27.5 1.1 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 Alba PF01918.21 EFC48855.1 - 0.013 15.3 2.1 35 4.3 0.0 3.9 3 0 0 3 3 3 0 Alba Matrilin_ccoil PF10393.9 EFC48855.1 - 0.1 12.5 2.5 0.72 9.8 0.6 3.1 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin YtzH PF14165.6 EFC48855.1 - 2.6 8.5 8.4 1.7 9.1 1.0 3.7 3 1 0 3 3 3 0 YtzH-like protein Sec63 PF02889.16 EFC48856.1 - 6e-28 97.7 0.3 1.2e-27 96.7 0.3 1.6 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 EFC48856.1 - 8.6e-27 94.0 0.0 2.2e-26 92.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC48856.1 - 1.1e-12 48.4 1.5 2.3e-12 47.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC48856.1 - 2e-10 41.0 3.2 9.3e-08 32.4 1.0 4.1 2 2 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFC48856.1 - 0.0016 18.7 0.1 0.0073 16.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 EFC48856.1 - 0.0036 17.1 2.8 0.18 11.6 0.0 3.0 2 1 1 3 3 3 1 AAA domain T2SSE PF00437.20 EFC48856.1 - 0.021 13.9 0.1 1.1 8.3 0.0 3.0 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_30 PF13604.6 EFC48856.1 - 0.024 14.4 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 EFC48856.1 - 0.052 13.9 0.0 0.21 11.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.6 EFC48856.1 - 0.056 13.6 0.5 0.57 10.3 0.3 2.6 2 1 0 2 2 2 0 Helicase C-terminal domain Helicase_RecD PF05127.14 EFC48856.1 - 0.08 12.8 0.0 0.36 10.7 0.0 2.2 2 0 0 2 2 2 0 Helicase Pterin_4a PF01329.19 EFC48857.1 - 1.2e-31 108.7 0.5 1.3e-31 108.6 0.5 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Phage_tail_T PF06223.12 EFC48858.1 - 0.025 15.1 2.3 0.73 10.4 0.1 2.8 2 0 0 2 2 2 0 Minor tail protein T Peptidase_M32 PF02074.15 EFC48858.1 - 4.2 6.0 13.7 0.2 10.4 7.9 1.7 2 0 0 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase DUF4578 PF15147.6 EFC48858.1 - 5.3 7.9 11.2 0.73 10.7 4.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) Methyltransf_PK PF05891.12 EFC48859.1 - 8.1e-53 179.2 0.3 9.1e-53 179.0 0.3 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 EFC48859.1 - 9.6e-07 29.4 0.0 2e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC48859.1 - 1.8e-05 25.4 0.0 3.4e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC48859.1 - 0.00045 20.8 0.0 0.00072 20.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Pox_E2-like PF04497.12 EFC48859.1 - 0.08 11.4 0.1 0.1 11.0 0.1 1.1 1 0 0 1 1 1 0 Poxviridae protein Peptidase_M54 PF07998.11 EFC48860.1 - 4.4e-11 43.1 0.2 6.9e-11 42.5 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_4 PF13583.6 EFC48860.1 - 0.0019 17.9 0.2 0.0028 17.3 0.2 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 EFC48860.1 - 0.0076 15.9 0.4 0.013 15.1 0.4 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M10 PF00413.24 EFC48860.1 - 0.017 15.0 0.0 0.026 14.4 0.0 1.6 1 1 1 2 2 2 0 Matrixin Reprolysin_2 PF13574.6 EFC48860.1 - 0.031 14.2 0.1 0.052 13.4 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 EFC48860.1 - 0.04 14.0 0.1 0.055 13.6 0.1 1.2 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 EFC48860.1 - 0.08 13.5 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 EFC48860.1 - 0.2 10.8 0.0 0.32 10.2 0.0 1.3 1 0 0 1 1 1 0 Met-zincin Pro-kuma_activ PF09286.11 EFC48861.1 - 3.5e-19 69.5 0.3 3.8e-18 66.1 0.3 2.5 2 1 1 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 EFC48861.1 - 1.2e-08 34.6 0.1 1.9e-08 34.0 0.1 1.2 1 0 0 1 1 1 1 Subtilase family DUF3074 PF11274.8 EFC48861.1 - 0.021 14.8 0.1 0.051 13.6 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) Ras PF00071.22 EFC48862.1 - 7e-55 185.1 0.5 8.5e-55 184.8 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC48862.1 - 1.9e-35 121.7 0.2 3.1e-35 121.0 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC48862.1 - 1.1e-12 47.7 0.9 1.4e-12 47.5 0.9 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC48862.1 - 6.7e-06 25.6 0.2 9.1e-06 25.2 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC48862.1 - 7.5e-05 22.3 0.6 0.00025 20.7 0.2 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC48862.1 - 0.0023 18.0 0.1 0.0042 17.2 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC48862.1 - 0.003 17.5 0.1 0.08 12.8 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase PglZ PF08665.12 EFC48862.1 - 0.03 14.4 0.1 0.047 13.8 0.1 1.4 1 0 0 1 1 1 0 PglZ domain G-alpha PF00503.20 EFC48862.1 - 0.074 12.2 0.1 0.83 8.7 0.1 2.0 2 0 0 2 2 2 0 G-protein alpha subunit Glyco_transf_4 PF13439.6 EFC48863.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Presenilin PF01080.17 EFC48863.1 - 4.5 5.9 7.3 7 5.3 7.3 1.3 1 0 0 1 1 1 0 Presenilin UPF0242 PF06785.11 EFC48864.1 - 0.014 15.5 8.5 0.014 15.5 8.5 3.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Glyoxalase_2 PF12681.7 EFC48864.1 - 3 7.8 9.6 0.16 11.9 0.9 3.1 2 2 2 4 4 4 0 Glyoxalase-like domain FlaC_arch PF05377.11 EFC48864.1 - 4.6 7.7 23.2 17 5.9 0.5 6.7 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) MAD PF05557.13 EFC48864.1 - 6.1 5.1 49.5 0.72 8.1 10.9 2.9 1 1 2 3 3 3 0 Mitotic checkpoint protein ThiF PF00899.21 EFC48865.1 - 3.2e-106 354.2 0.0 6.3e-70 235.3 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 EFC48865.1 - 2.8e-93 312.4 1.2 5.4e-93 311.5 1.2 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 EFC48865.1 - 4.7e-28 97.7 0.1 2.2e-27 95.6 0.1 2.3 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 EFC48865.1 - 3.5e-24 84.8 1.3 9.9e-24 83.3 1.3 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 EFC48865.1 - 4.7e-19 68.3 0.4 2.1e-18 66.3 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 EFC48865.1 - 0.082 13.0 0.5 1.6 8.8 0.1 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TP_methylase PF00590.20 EFC48866.1 - 9.1e-15 55.2 0.0 2e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF952 PF06108.12 EFC48867.1 - 1.1e-13 51.0 0.0 1.4e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF952) MgtE PF01769.16 EFC48868.1 - 0.12 12.7 0.0 0.16 12.4 0.0 1.1 1 0 0 1 1 1 0 Divalent cation transporter NAD_binding_6 PF08030.12 EFC48869.1 - 5.4e-17 62.4 0.2 6.2e-09 36.2 0.0 2.5 1 1 1 2 2 2 2 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 EFC48869.1 - 6.2e-17 61.9 18.3 1.7e-16 60.5 14.7 2.4 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DOMON PF03351.17 EFC48869.1 - 7.3e-06 26.2 0.1 1.6e-05 25.1 0.1 1.7 1 0 0 1 1 1 1 DOMON domain FAD_binding_8 PF08022.12 EFC48869.1 - 1.5e-05 25.1 0.0 3.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 EFC48869.1 - 2.6e-05 24.8 0.0 4.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF4079 PF13301.6 EFC48869.1 - 5.8 7.1 10.1 5.3 7.2 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) F-box-like PF12937.7 EFC48870.1 - 0.00017 21.4 0.6 0.00037 20.3 0.6 1.7 1 1 0 1 1 1 1 F-box-like F-box PF00646.33 EFC48870.1 - 0.00044 20.0 0.3 0.54 10.2 0.1 3.0 3 0 0 3 3 3 2 F-box domain Prominin PF05478.11 EFC48870.1 - 0.006 14.6 0.1 0.006 14.6 0.1 1.1 1 0 0 1 1 1 1 Prominin F-box-like_2 PF13013.6 EFC48870.1 - 0.019 14.9 2.6 0.18 11.8 1.0 2.3 1 1 1 2 2 2 0 F-box-like domain CM_2 PF01817.21 EFC48870.1 - 0.097 13.0 0.4 1 9.8 0.0 2.4 2 1 0 2 2 2 0 Chorismate mutase type II RhaA PF06134.11 EFC48870.1 - 0.14 11.2 0.0 0.17 11.0 0.0 1.0 1 0 0 1 1 1 0 L-rhamnose isomerase (RhaA) SET PF00856.28 EFC48871.1 - 0.00013 22.4 3.7 0.00055 20.4 3.7 2.2 1 1 0 1 1 1 1 SET domain TPR_1 PF00515.28 EFC48871.1 - 0.089 12.7 0.1 0.42 10.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC48871.1 - 0.094 13.0 0.0 16 5.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC48871.1 - 0.097 12.8 0.1 0.49 10.6 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC48871.1 - 0.15 12.7 0.0 0.27 11.9 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-MYND PF01753.18 EFC48871.1 - 2 8.6 23.2 0.087 12.9 16.2 2.2 2 0 0 2 2 2 0 MYND finger Nup160 PF11715.8 EFC48872.1 - 0.06 12.0 0.3 0.093 11.4 0.3 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Cyt-b5 PF00173.28 EFC48873.1 - 5.3e-23 81.0 0.0 1e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.24 EFC48873.1 - 2.1e-21 76.1 0.1 7.9e-21 74.3 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 EFC48873.1 - 1.2e-15 58.1 0.1 3.6e-15 56.6 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 EFC48873.1 - 4.5e-08 33.4 0.3 1.1e-07 32.1 0.3 1.7 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DEAD PF00270.29 EFC48874.1 - 7.9e-49 165.8 0.2 3.9e-47 160.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC48874.1 - 4.1e-28 98.0 0.0 1.2e-26 93.3 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC48874.1 - 5.1e-09 36.4 0.2 1.3e-07 31.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 EFC48874.1 - 5.8e-05 23.5 0.0 0.018 15.4 0.0 2.2 2 0 0 2 2 2 2 AAA domain SNF2_N PF00176.23 EFC48874.1 - 0.0033 16.2 0.0 0.0056 15.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Ribosomal_60s PF00428.19 EFC48875.1 - 7.2e-22 77.8 3.6 1e-21 77.3 3.6 1.2 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 EFC48875.1 - 0.041 14.3 0.9 0.046 14.1 0.1 1.4 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) TMEM171 PF15471.6 EFC48876.1 - 0.7 8.8 4.8 1.1 8.2 4.8 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Proteasome PF00227.26 EFC48877.1 - 3.3e-56 189.8 0.3 4.2e-56 189.4 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFC48877.1 - 3.2e-14 52.3 0.0 7.6e-14 51.1 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Glyco_hydro_1 PF00232.18 EFC48877.1 - 0.11 10.9 0.0 0.19 10.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 C2 PF00168.30 EFC48878.1 - 5e-19 68.5 0.2 1e-08 35.4 0.0 5.2 5 0 0 5 5 5 3 C2 domain Cation_efflux PF01545.21 EFC48879.1 - 6.2e-26 91.4 8.0 3.3e-21 75.9 0.5 2.1 2 0 0 2 2 2 2 Cation efflux family ATG_C PF09333.11 EFC48880.1 - 9.2e-10 38.7 0.1 2.1e-08 34.4 0.0 2.9 2 1 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 EFC48880.1 - 2.9e-07 30.4 2.9 2.3e-06 27.5 0.4 3.3 2 1 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 EFC48880.1 - 1.1e-06 28.7 1.6 0.0021 18.1 0.2 3.8 3 0 0 3 3 3 2 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 EFC48880.1 - 9.1e-06 25.5 1.1 5.1e-05 23.0 1.1 2.4 1 1 0 1 1 1 1 Autophagy-related protein 2 CAD motif GRAM PF02893.20 EFC48880.1 - 0.035 14.0 0.2 0.28 11.1 0.0 2.6 2 0 0 2 2 2 0 GRAM domain SNF2_N PF00176.23 EFC48881.1 - 1.5e-39 135.7 0.1 2.1e-39 135.2 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC48881.1 - 3.3e-19 69.3 0.0 1.5e-18 67.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFC48881.1 - 0.0048 16.1 0.0 0.0091 15.2 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SPT2 PF08243.11 EFC48881.1 - 0.018 15.6 3.8 0.047 14.2 3.8 1.7 1 0 0 1 1 1 0 SPT2 chromatin protein SWI2_SNF2 PF18766.1 EFC48881.1 - 0.069 12.8 0.0 0.32 10.6 0.0 2.1 2 0 0 2 2 2 0 SWI2/SNF2 ATPase NOA36 PF06524.12 EFC48881.1 - 0.078 12.3 3.7 0.12 11.6 3.7 1.2 1 0 0 1 1 1 0 NOA36 protein Importin_rep_6 PF18829.1 EFC48881.1 - 0.2 11.8 1.8 0.61 10.2 1.8 1.8 1 0 0 1 1 1 0 Importin repeat 6 Histone PF00125.24 EFC48882.1 - 7.5e-21 74.9 0.9 1e-20 74.4 0.9 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 EFC48882.1 - 0.00079 19.7 0.1 0.0033 17.7 0.0 1.9 1 1 1 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone MRP-L28 PF09812.9 EFC48882.1 - 0.061 13.5 1.5 0.074 13.2 1.4 1.3 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L28 CENP-T_C PF15511.6 EFC48882.1 - 0.11 12.6 1.0 0.28 11.3 0.5 1.8 1 1 1 2 2 2 0 Centromere kinetochore component CENP-T histone fold AAA PF00004.29 EFC48883.1 - 2.5e-38 131.5 0.0 4e-38 130.8 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 EFC48883.1 - 2.7e-11 43.3 0.0 1.6e-08 34.4 0.0 2.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 EFC48883.1 - 1.1e-09 38.0 0.0 3e-09 36.5 0.0 1.8 2 0 0 2 2 1 1 AAA+ lid domain RuvB_N PF05496.12 EFC48883.1 - 3.6e-06 26.8 0.0 1.7e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC48883.1 - 4.7e-05 23.4 0.3 0.0011 19.0 0.3 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFC48883.1 - 0.00015 21.9 0.0 0.00025 21.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 EFC48883.1 - 0.0004 19.7 0.0 0.001 18.4 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 EFC48883.1 - 0.00051 20.3 0.7 0.017 15.4 0.5 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC48883.1 - 0.001 19.5 1.3 0.17 12.3 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 EFC48883.1 - 0.006 16.3 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 EFC48883.1 - 0.0062 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 EFC48883.1 - 0.021 14.2 0.2 2.3 7.5 0.2 2.3 1 1 1 2 2 2 0 KaiC AAA_30 PF13604.6 EFC48883.1 - 0.041 13.6 0.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 EFC48883.1 - 0.046 13.1 0.2 0.12 11.7 0.2 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TniB PF05621.11 EFC48883.1 - 0.063 12.7 0.0 14 5.1 0.0 2.8 1 1 1 3 3 3 0 Bacterial TniB protein AAA_18 PF13238.6 EFC48883.1 - 0.07 13.7 0.1 0.12 12.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 EFC48883.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 EFC48883.1 - 0.14 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 EFC48883.1 - 0.15 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 EFC48883.1 - 0.19 12.1 0.1 0.42 10.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 EFC48883.1 - 0.21 11.3 0.0 0.5 10.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain SPRY PF00622.28 EFC48884.1 - 8.6e-15 54.9 6.7 2.6e-09 37.2 1.5 3.4 2 0 0 2 2 2 2 SPRY domain TPT PF03151.16 EFC48885.1 - 2.6e-14 53.2 20.5 3.1e-14 53.0 20.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC48885.1 - 1.5e-10 41.4 29.4 4.4e-07 30.1 10.3 2.2 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 EFC48885.1 - 4.6e-05 22.8 25.9 5.8e-05 22.4 25.9 1.2 1 0 0 1 1 1 1 UAA transporter family TraE PF05309.11 EFC48885.1 - 0.89 8.9 7.9 0.15 11.4 3.1 2.0 2 1 0 2 2 2 0 TraE protein DUF1385 PF07136.11 EFC48885.1 - 1.7 7.9 11.1 0.35 10.1 6.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1385) Vip3A_N PF12495.8 EFC48886.1 - 0.032 14.1 2.5 0.27 11.1 2.5 2.5 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal FdsD PF11390.8 EFC48886.1 - 0.07 13.5 0.1 0.24 11.7 0.1 1.9 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD IFT20 PF14931.6 EFC48887.1 - 2.2e-37 127.8 10.4 2.5e-37 127.7 10.4 1.0 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 RE_AlwI PF09491.10 EFC48887.1 - 0.014 14.2 7.1 0.015 14.1 7.1 1.1 1 0 0 1 1 1 0 AlwI restriction endonuclease Acetate_kinase PF00871.17 EFC48887.1 - 0.067 11.9 0.7 0.095 11.4 0.4 1.3 1 1 0 1 1 1 0 Acetokinase family ApbA_C PF08546.11 EFC48887.1 - 0.087 13.0 0.4 0.1 12.8 0.4 1.3 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Exonuc_VII_L PF02601.15 EFC48887.1 - 0.26 10.8 3.8 0.28 10.7 3.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 EFC48887.1 - 0.65 9.0 8.3 0.97 8.5 8.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Actin PF00022.19 EFC48888.1 - 6.5e-09 34.9 0.0 1e-07 30.9 0.0 2.1 1 1 0 1 1 1 1 Actin LRR_6 PF13516.6 EFC48889.1 - 1.2e-13 49.9 30.1 0.00047 20.0 0.5 7.2 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 EFC48889.1 - 4.8e-06 26.8 38.7 0.004 17.5 3.7 6.4 4 1 2 7 7 7 4 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC48889.1 - 0.00017 21.4 0.2 0.001 18.9 0.2 2.4 1 0 0 1 1 1 1 F-box domain LRR_8 PF13855.6 EFC48889.1 - 0.00054 19.7 33.2 0.17 11.7 0.6 6.3 3 2 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 EFC48889.1 - 0.029 14.9 25.2 2.2 9.2 0.1 7.9 8 1 0 8 8 8 0 Leucine Rich Repeat F-box-like PF12937.7 EFC48889.1 - 0.046 13.6 0.1 0.12 12.3 0.1 1.6 1 0 0 1 1 1 0 F-box-like Sacchrp_dh_NADP PF03435.18 EFC48890.1 - 3.2e-07 30.7 0.0 8.4e-07 29.3 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Peptidase_C25_C PF03785.14 EFC48890.1 - 0.24 11.3 1.7 10 6.0 0.1 2.4 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain DUF4695 PF15766.5 EFC48891.1 - 0.00031 20.9 0.2 0.00031 20.9 0.2 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4695) Ribosomal_L12_N PF16320.5 EFC48891.1 - 3.9 7.2 9.0 2.9 7.6 1.4 3.1 3 0 0 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain LRR_6 PF13516.6 EFC48892.1 - 3.3e-08 33.0 5.3 0.00015 21.6 0.1 6.2 6 0 0 6 6 6 2 Leucine Rich repeat LRR_4 PF12799.7 EFC48892.1 - 0.0013 19.1 3.8 4 8.0 0.0 5.1 3 1 2 5 5 5 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC48892.1 - 0.053 13.3 1.5 31 4.4 0.0 3.9 3 1 0 3 3 3 0 Leucine rich repeat UQ_con PF00179.26 EFC48893.1 - 3e-43 146.8 0.0 3.6e-43 146.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 EFC48893.1 - 0.12 12.1 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B T2SSE PF00437.20 EFC48894.1 - 1.2e-17 63.9 0.0 1.8e-17 63.3 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF87 PF01935.17 EFC48894.1 - 0.00027 21.1 0.2 0.00027 21.1 0.2 2.2 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 EFC48894.1 - 0.00047 19.6 0.0 0.00082 18.8 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_23 PF13476.6 EFC48894.1 - 0.0018 18.8 0.4 0.0018 18.8 0.4 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFC48894.1 - 0.002 17.8 0.5 0.0052 16.5 0.1 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC48894.1 - 0.0021 18.5 0.0 0.0048 17.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 EFC48894.1 - 0.0022 18.4 0.0 0.0053 17.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 EFC48894.1 - 0.0025 18.3 0.0 0.0025 18.3 0.0 2.7 2 1 0 2 2 1 1 ABC transporter SMC_N PF02463.19 EFC48894.1 - 0.0028 17.1 0.0 0.0067 15.9 0.0 1.6 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 EFC48894.1 - 0.0029 17.1 0.0 0.0066 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 EFC48894.1 - 0.01 16.1 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATP-synt_ab PF00006.25 EFC48894.1 - 0.032 13.9 0.0 0.038 13.7 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_5 PF07728.14 EFC48894.1 - 0.033 14.2 0.0 0.16 12.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TrwB_AAD_bind PF10412.9 EFC48894.1 - 0.033 13.1 0.0 0.061 12.2 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain RNA_helicase PF00910.22 EFC48894.1 - 0.034 14.5 0.0 0.084 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NACHT PF05729.12 EFC48894.1 - 0.061 13.2 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 EFC48894.1 - 0.088 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 EFC48894.1 - 0.088 12.8 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 EFC48894.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 EFC48894.1 - 0.12 12.3 0.1 0.58 10.1 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EFC48894.1 - 0.13 12.8 0.0 0.36 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFC48894.1 - 0.15 12.2 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFC48894.1 - 0.2 11.5 1.0 2.8 7.8 0.0 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_30 PF13604.6 EFC48894.1 - 0.25 11.1 0.2 0.52 10.0 0.0 1.5 2 0 0 2 2 1 0 AAA domain VLPT PF07122.11 EFC48894.1 - 0.42 10.4 4.5 1 9.1 4.5 1.8 1 0 0 1 1 1 0 Variable length PCR target protein (VLPT) DUF3797 PF12677.7 EFC48894.1 - 0.44 10.5 2.2 7.1 6.6 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) zinc_ribbon_9 PF14369.6 EFC48894.1 - 0.46 10.8 4.9 3.3 8.0 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon Adap_comp_sub PF00928.21 EFC48895.1 - 2.6e-55 187.6 0.5 3.5e-55 187.2 0.5 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 EFC48895.1 - 0.0015 18.5 0.7 0.0027 17.6 0.7 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ribosomal_L24 PF17136.4 EFC48896.1 - 3e-20 72.4 0.3 5.1e-20 71.6 0.3 1.4 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 EFC48896.1 - 4.3e-09 36.0 5.0 6.6e-09 35.4 5.0 1.3 1 0 0 1 1 1 1 KOW motif Biotin_lipoyl PF00364.22 EFC48896.1 - 0.31 10.9 2.2 0.72 9.7 0.1 2.4 3 0 0 3 3 3 0 Biotin-requiring enzyme DUF3522 PF12036.8 EFC48897.1 - 3.6e-25 89.4 15.3 2.1e-14 54.3 2.6 2.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3522) Tom37 PF10568.9 EFC48897.1 - 0.026 14.8 0.0 0.049 13.9 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein Cytochrom_B_N_2 PF13631.6 EFC48897.1 - 0.85 9.6 5.7 0.34 10.9 0.8 2.6 3 0 0 3 3 3 0 Cytochrome b(N-terminal)/b6/petB DUF4131 PF13567.6 EFC48897.1 - 1 9.0 4.5 0.83 9.3 1.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Cluap1 PF10234.9 EFC48898.1 - 1.5e-65 221.3 22.8 2.3e-65 220.7 22.8 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 Sipho_Gp157 PF05565.11 EFC48898.1 - 0.0058 16.7 11.4 0.0058 16.7 11.4 2.6 1 1 0 2 2 2 1 Siphovirus Gp157 Pox_mRNA-cap PF03341.13 EFC48898.1 - 0.031 13.6 1.0 0.051 12.9 1.0 1.4 1 0 0 1 1 1 0 Poxvirus mRNA capping enzyme, small subunit GIT_CC PF16559.5 EFC48898.1 - 0.034 14.0 0.4 0.034 14.0 0.4 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fez1 PF06818.15 EFC48898.1 - 0.25 11.8 30.6 0.19 12.2 10.1 2.6 1 1 1 2 2 2 0 Fez1 Laminin_II PF06009.12 EFC48898.1 - 9.7 6.2 14.3 0.49 10.4 2.5 2.4 1 1 1 2 2 2 0 Laminin Domain II AATF-Che1 PF13339.6 EFC48899.1 - 2.5e-27 96.2 1.5 2.5e-27 96.2 1.5 2.7 2 1 1 3 3 3 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 EFC48899.1 - 4.6e-12 46.3 0.0 4.6e-12 46.3 0.0 4.1 4 0 0 4 4 4 1 Apoptosis-antagonizing transcription factor, C-terminal ATG101 PF07855.12 EFC48900.1 - 1.7e-05 24.9 0.8 3.4e-05 23.9 0.8 1.5 1 1 0 1 1 1 1 Autophagy-related protein 101 Macoilin PF09726.9 EFC48901.1 - 0.092 11.3 7.9 0.1 11.1 7.9 1.0 1 0 0 1 1 1 0 Macoilin family Binary_toxB_3 PF17476.2 EFC48901.1 - 0.1 12.8 0.4 0.16 12.1 0.1 1.4 2 0 0 2 2 2 0 Clostridial binary toxin B/anthrax toxin PA domain 3 Nop53 PF07767.11 EFC48902.1 - 1.7e-05 24.4 31.7 1.7e-05 24.4 30.9 1.4 1 1 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) zf-C2H2_4 PF13894.6 EFC48903.1 - 2.2e-09 37.3 4.0 9.4e-05 22.9 0.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 EFC48903.1 - 9.3e-07 29.0 4.4 0.00061 20.0 0.4 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 EFC48903.1 - 3.4e-06 27.2 4.1 0.00087 19.5 1.0 2.1 1 1 1 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 EFC48903.1 - 1.4e-05 25.3 3.6 0.052 14.0 0.4 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EFC48903.1 - 0.00072 19.8 2.0 0.03 14.6 0.6 2.1 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) Rad50_zn_hook PF04423.14 EFC48903.1 - 0.0078 16.0 3.1 0.24 11.2 1.1 2.2 1 1 1 2 2 2 1 Rad50 zinc hook motif DUF629 PF04780.12 EFC48903.1 - 0.0079 14.8 0.6 0.0079 14.8 0.6 1.4 1 1 1 2 2 2 1 Protein of unknown function (DUF629) zf-H2C2_2 PF13465.6 EFC48903.1 - 0.015 15.7 1.5 0.015 15.7 1.5 2.5 3 0 0 3 3 3 0 Zinc-finger double domain PyrI_C PF02748.15 EFC48903.1 - 0.042 13.8 7.4 1.3 9.0 1.1 2.4 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_12 PF18658.1 EFC48903.1 - 0.044 13.4 0.9 0.048 13.2 0.6 1.3 1 1 0 1 1 1 0 Zinc-finger C2H2-type zf-BED PF02892.15 EFC48903.1 - 0.055 13.5 5.1 0.44 10.6 5.1 2.1 1 1 0 1 1 1 0 BED zinc finger HNH_5 PF14279.6 EFC48903.1 - 0.063 13.1 1.5 0.77 9.7 0.6 2.2 2 1 0 2 2 2 0 HNH endonuclease HypA PF01155.19 EFC48903.1 - 0.095 12.7 0.3 0.12 12.4 0.3 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_6 PF13912.6 EFC48903.1 - 0.13 12.3 4.1 0.31 11.1 0.5 2.3 1 1 1 2 2 2 0 C2H2-type zinc finger zf-CHCC PF10276.9 EFC48903.1 - 0.24 11.5 6.1 5.3 7.2 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger domain zinc_ribbon_9 PF14369.6 EFC48903.1 - 0.36 11.1 6.8 1.1 9.6 6.8 1.8 1 1 0 1 1 1 0 zinc-ribbon DUF4187 PF13821.6 EFC48903.1 - 0.47 10.3 4.2 2.9 7.7 1.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4187) zf-C2HC_2 PF13913.6 EFC48903.1 - 1.2 9.2 0.0 1.2 9.2 0.0 2.8 3 0 0 3 3 3 0 zinc-finger of a C2HC-type Ank_2 PF12796.7 EFC48904.1 - 3.7e-33 114.0 0.2 3.3e-14 53.2 0.0 3.7 1 1 4 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC48904.1 - 3.5e-17 60.7 0.1 6.1e-05 23.1 0.0 6.3 6 1 1 7 7 7 3 Ankyrin repeat Ank_4 PF13637.6 EFC48904.1 - 2.8e-14 53.3 0.1 0.00091 19.8 0.0 4.7 4 1 0 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC48904.1 - 2.3e-13 49.9 0.6 0.0081 16.6 0.0 5.9 6 1 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 EFC48904.1 - 2.1e-12 47.0 0.0 0.0012 19.1 0.0 4.8 6 0 0 6 6 6 3 Ankyrin repeats (many copies) ComS PF17584.2 EFC48904.1 - 0.16 11.5 0.3 0.54 9.8 0.1 2.0 2 0 0 2 2 2 0 Bacillus competence protein S Cadherin_C_2 PF16492.5 EFC48905.1 - 0.1 13.3 3.2 2.8 8.7 1.5 2.4 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF4446 PF14584.6 EFC48905.1 - 0.74 9.8 3.8 10 6.1 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Abhydrolase_6 PF12697.7 EFC48906.1 - 5.8e-08 33.6 0.0 8.5e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC48906.1 - 8.5e-07 28.5 0.0 2.4e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC48906.1 - 4.1e-06 26.6 0.0 1.3e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 EFC48906.1 - 3e-05 23.6 0.0 6.1e-05 22.6 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 EFC48906.1 - 0.00029 20.6 0.0 0.0004 20.1 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S15 PF02129.18 EFC48906.1 - 0.00098 18.8 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 EFC48906.1 - 0.0093 15.9 0.0 0.02 14.8 0.0 1.5 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal PAF-AH_p_II PF03403.13 EFC48906.1 - 0.01 14.4 0.0 0.018 13.6 0.0 1.3 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Frataxin_Cyay PF01491.16 EFC48907.1 - 1.5e-23 82.9 0.8 2.4e-23 82.2 0.2 1.6 2 0 0 2 2 2 1 Frataxin-like domain SF3b10 PF07189.11 EFC48909.1 - 1.5e-33 114.7 0.0 1.7e-33 114.6 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Paz_1 PF18349.1 EFC48910.1 - 0.0032 17.4 0.2 0.021 14.8 0.2 2.5 1 1 0 1 1 1 1 PAZ domain SMC_Nse1 PF07574.13 EFC48911.1 - 2.8e-22 79.5 6.5 1.6e-21 77.1 6.5 1.8 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex Glyco_hydro_7 PF00840.20 EFC48911.1 - 0.0077 15.0 0.1 0.01 14.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 RRM_1 PF00076.22 EFC48912.1 - 1.1e-08 34.8 0.0 2.4e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 EFC48912.1 - 2.7e-05 24.4 1.4 0.00011 22.4 0.2 2.7 2 0 0 2 2 2 1 PWI domain eRF1_2 PF03464.15 EFC48913.1 - 4.2e-30 104.8 0.0 7.1e-30 104.0 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFC48913.1 - 4.4e-14 52.9 0.3 8e-14 52.1 0.3 1.4 1 0 0 1 1 1 1 eRF1 domain 3 acVLRF1 PF18859.1 EFC48913.1 - 2e-10 41.1 0.0 3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EFC48913.1 - 1.9e-06 28.1 0.0 3.3e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 ARL2_Bind_BART PF11527.8 EFC48914.1 - 2.2e-19 69.7 7.6 2.6e-19 69.4 7.6 1.0 1 0 0 1 1 1 1 The ARF-like 2 binding protein BART DUF348 PF03990.14 EFC48914.1 - 0.1 12.4 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain IML1 PF12257.8 EFC48915.1 - 9.7e-89 297.3 2.2 1.9e-88 296.3 2.2 1.5 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 cNMP_binding PF00027.29 EFC48916.1 - 4.5e-40 135.6 0.1 7.2e-21 74.1 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain TFIIA PF03153.13 EFC48916.1 - 0.077 13.0 12.0 0.1 12.6 12.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nucleo_P87 PF07267.11 EFC48916.1 - 0.24 10.2 7.2 0.35 9.7 7.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Glyco_hydro_47 PF01532.20 EFC48917.1 - 1.5e-147 492.2 0.0 1.9e-147 491.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 SieB PF14163.6 EFC48917.1 - 0.13 11.8 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B Baculo_11_kDa PF06143.11 EFC48917.1 - 0.16 11.6 0.1 0.33 10.6 0.1 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family Glyco_hydro_127 PF07944.12 EFC48917.1 - 0.17 10.3 0.0 8.3 4.8 0.0 2.5 2 1 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 DSPc PF00782.20 EFC48918.1 - 1e-26 93.3 0.1 5.6e-26 90.9 0.1 2.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_8 PF13855.6 EFC48918.1 - 2.3e-20 72.1 48.9 1.6e-10 40.6 0.1 10.2 8 1 1 9 9 9 7 Leucine rich repeat LRR_4 PF12799.7 EFC48918.1 - 2.2e-13 50.2 66.5 4.7e-05 23.7 0.3 11.0 6 3 4 11 11 11 7 Leucine Rich repeats (2 copies) Y_phosphatase PF00102.27 EFC48918.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase LRR_6 PF13516.6 EFC48918.1 - 0.06 13.4 35.4 2.6 8.3 0.2 10.8 12 0 0 12 12 12 0 Leucine Rich repeat CDKN3 PF05706.12 EFC48918.1 - 0.072 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Mannosyl_trans PF05007.13 EFC48919.1 - 2.9e-71 240.4 26.8 4.7e-71 239.7 26.8 1.3 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 EFC48919.1 - 2.1e-11 43.5 34.7 1.6e-10 40.6 34.7 1.9 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 EFC48919.1 - 2.9e-09 37.0 2.1 2.9e-09 37.0 2.1 1.8 2 0 0 2 2 2 1 Glycosyltransferase family 87 PMT_2 PF13231.6 EFC48919.1 - 0.0014 18.9 9.1 0.0014 18.9 9.1 2.8 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Popeye PF04831.13 EFC48919.1 - 3.7 7.7 14.9 3.4 7.8 0.1 3.7 3 1 1 4 4 4 0 Popeye protein conserved region F-box-like PF12937.7 EFC48920.1 - 0.054 13.4 1.2 0.17 11.8 0.1 2.4 3 0 0 3 3 3 0 F-box-like DUF4097 PF13349.6 EFC48920.1 - 0.085 12.2 1.2 0.17 11.2 0.2 2.0 2 0 0 2 2 2 0 Putative adhesin F-box PF00646.33 EFC48920.1 - 0.12 12.2 1.1 0.41 10.6 0.2 2.5 2 0 0 2 2 2 0 F-box domain 2OG-FeII_Oxy_2 PF13532.6 EFC48921.1 - 1.2e-57 195.3 0.0 1.5e-57 195.0 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1823 PF08853.11 EFC48921.1 - 0.033 14.4 1.3 2.4 8.4 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF1823) Pkinase PF00069.25 EFC48923.1 - 1.4e-64 218.0 0.1 1.6e-64 217.8 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48923.1 - 3.9e-33 114.8 0.1 4.8e-33 114.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC48923.1 - 3.2e-05 23.4 0.0 6.3e-05 22.4 0.0 1.5 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 EFC48923.1 - 0.0001 22.0 0.2 0.00014 21.5 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EFC48923.1 - 0.00084 18.4 0.3 0.00099 18.1 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC48923.1 - 0.0088 15.4 0.1 0.013 14.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC48923.1 - 0.035 14.0 0.3 0.91 9.4 0.5 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC48923.1 - 0.04 13.5 0.7 0.062 12.9 0.7 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase SIS PF01380.22 EFC48924.1 - 0.087 12.7 0.2 0.64 9.9 0.0 2.4 2 0 0 2 2 2 0 SIS domain Serinc PF03348.15 EFC48925.1 - 1.3e-24 87.0 32.9 3.7e-24 85.4 32.9 1.6 1 1 0 1 1 1 1 Serine incorporator (Serinc) DYW_deaminase PF14432.6 EFC48926.1 - 2e-38 131.1 0.1 6.4e-38 129.5 0.1 1.9 1 0 0 1 1 1 1 DYW family of nucleic acid deaminases PPR PF01535.20 EFC48926.1 - 3.1e-31 105.4 13.4 0.0001 22.3 0.1 9.4 8 2 2 10 10 9 6 PPR repeat PPR_2 PF13041.6 EFC48926.1 - 7.1e-25 86.9 12.4 0.00058 20.0 0.0 7.5 6 2 1 7 7 7 5 PPR repeat family TPR_19 PF14559.6 EFC48926.1 - 5.2e-08 33.3 1.1 1 9.9 0.0 5.1 4 1 1 5 5 5 2 Tetratricopeptide repeat PPR_1 PF12854.7 EFC48926.1 - 2.2e-05 24.1 9.4 8 6.3 0.1 7.0 9 0 0 9 9 9 0 PPR repeat PPR_3 PF13812.6 EFC48926.1 - 4e-05 23.6 11.1 1.4 9.1 0.1 6.4 2 1 5 8 8 8 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC48926.1 - 0.00024 20.5 2.4 0.22 10.8 0.5 3.7 1 1 3 4 4 4 3 Pentacotripeptide-repeat region of PRORP Acetyltransf_19 PF18015.1 EFC48926.1 - 0.0015 18.7 5.7 6.7 7.0 0.1 4.5 3 1 1 4 4 4 1 Acetyltransferase (GNAT) domain Phage_ABA_S PF18066.1 EFC48926.1 - 0.0026 18.4 5.9 1 10.1 0.2 4.2 3 1 1 4 4 4 1 Phage ABA sandwich domain TPR_14 PF13428.6 EFC48926.1 - 0.0044 17.7 0.0 1.5e+02 3.6 0.0 5.4 6 1 1 7 7 5 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EFC48926.1 - 0.0079 16.5 11.7 0.92 9.8 0.1 5.0 3 3 2 5 5 5 1 Vacuolar sorting protein 39 domain 1 PRA-PH PF01503.17 EFC48926.1 - 0.011 16.2 0.1 0.08 13.4 0.2 2.2 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF2095 PF09868.9 EFC48926.1 - 0.011 15.6 2.7 7.4 6.6 0.0 4.0 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2095) TBPIP PF07106.13 EFC48926.1 - 0.016 15.1 1.7 5.8 6.9 0.0 3.4 4 0 0 4 4 3 0 TBPIP/Hop2 winged helix domain RPN7 PF10602.9 EFC48926.1 - 0.024 14.4 1.8 2.1 8.0 0.1 3.7 3 1 0 3 3 3 0 26S proteasome subunit RPN7 ZapA PF05164.13 EFC48926.1 - 0.046 14.1 0.1 0.52 10.8 0.0 2.6 2 0 0 2 2 2 0 Cell division protein ZapA Prp18 PF02840.15 EFC48926.1 - 0.061 13.4 3.0 7.9 6.5 0.2 3.0 2 0 0 2 2 2 0 Prp18 domain TPR_6 PF13174.6 EFC48926.1 - 0.069 13.8 2.5 58 4.6 0.0 4.9 6 1 0 6 6 2 0 Tetratricopeptide repeat TPR_15 PF13429.6 EFC48926.1 - 0.078 12.2 0.0 5.3 6.2 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC48926.1 - 0.11 12.5 0.3 11 6.3 0.0 4.2 6 0 0 6 6 4 0 Tetratricopeptide repeat DegV PF02645.16 EFC48926.1 - 0.2 10.9 2.2 9.6 5.4 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised protein, DegV family COG1307 Fer4_12 PF13353.6 EFC48926.1 - 0.41 10.9 5.7 24 5.2 0.2 3.8 3 2 1 4 4 4 0 4Fe-4S single cluster domain TPR_8 PF13181.6 EFC48926.1 - 1.9 8.9 8.9 26 5.4 0.0 5.0 6 1 1 7 7 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC48926.1 - 2.2 8.3 7.7 19 5.3 0.0 5.2 7 0 0 7 7 6 0 Tetratricopeptide repeat AvrRpt-cleavage PF05627.11 EFC48926.1 - 3.4 7.1 4.1 37 3.8 0.2 3.1 3 0 0 3 3 3 0 Cleavage site for pathogenic type III effector avirulence factor Avr DUF4268 PF14088.6 EFC48926.1 - 6.5 6.6 16.0 17 5.3 0.1 4.9 4 1 1 5 5 5 0 Domain of unknown function (DUF4268) B9-C2 PF07162.11 EFC48927.1 - 3.3e-46 157.6 0.0 3.8e-46 157.4 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein T2SSG PF08334.11 EFC48928.1 - 1.8e-05 24.8 0.5 0.0004 20.4 0.3 2.5 1 1 0 1 1 1 1 Type II secretion system (T2SS), protein G Radical_SAM_C PF16199.5 EFC48929.1 - 2.9e-32 110.5 0.0 7.6e-32 109.2 0.0 1.8 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 EFC48929.1 - 2.2e-18 67.2 0.4 2.3e-17 63.9 0.1 2.5 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 EFC48929.1 - 3.5e-10 40.1 0.0 9.8e-10 38.7 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC48929.1 - 3.5e-06 27.0 0.1 1.9e-05 24.6 0.1 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC48929.1 - 0.00042 20.7 0.1 0.00085 19.7 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC48929.1 - 0.021 14.8 0.0 0.055 13.4 0.0 1.7 1 0 0 1 1 1 0 FR47-like protein NolV PF06635.12 EFC48929.1 - 0.052 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein NolV FYRN PF05964.14 EFC48931.1 - 3.8e-23 81.1 1.6 7.8e-23 80.1 1.6 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 EFC48931.1 - 3.6e-16 59.1 0.0 9e-16 57.8 0.0 1.7 1 0 0 1 1 1 1 F/Y rich C-terminus IL4_i_Ig PF18258.1 EFC48932.1 - 0.27 11.5 2.0 17 5.7 0.0 2.6 2 0 0 2 2 2 0 Interleukin-4 inducing immunoglobulin-binding domain Peptidase_M24 PF00557.24 EFC48933.1 - 1.4e-58 198.1 0.0 1.8e-58 197.7 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFC48933.1 - 2.5e-22 78.9 0.0 5.8e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Creatinase_N PF01321.18 EFC48933.1 - 0.00064 20.4 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Peptidase_S8_N PF16361.5 EFC48933.1 - 0.054 14.0 0.1 0.42 11.1 0.0 2.3 2 1 0 2 2 2 0 N-terminal of Subtilase family Cdd1 PF11731.8 EFC48933.1 - 0.11 12.7 0.1 0.28 11.5 0.1 1.6 1 0 0 1 1 1 0 Pathogenicity locus p450 PF00067.22 EFC48934.1 - 2.9e-71 240.6 0.0 3.5e-71 240.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LtuB PF17455.2 EFC48934.1 - 0.13 12.9 0.1 0.32 11.7 0.1 1.6 1 0 0 1 1 1 0 Late transcription unit B Prp18 PF02840.15 EFC48935.1 - 1.3e-56 190.6 0.5 1.5e-56 190.5 0.5 1.0 1 0 0 1 1 1 1 Prp18 domain DUF2653 PF10850.8 EFC48935.1 - 0.049 13.8 0.1 0.069 13.4 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2653) DUF5398 PF17376.2 EFC48936.1 - 0.015 15.9 0.4 0.04 14.6 0.4 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5398) ETS_PEA3_N PF04621.13 EFC48936.1 - 1.7 8.4 5.5 3.2 7.5 5.5 1.4 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain Med27 PF11571.8 EFC48937.1 - 1.1e-06 28.9 6.2 2.3e-06 27.9 3.1 2.7 2 0 0 2 2 2 1 Mediator complex subunit 27 RPN7 PF10602.9 EFC48937.1 - 0.39 10.4 1.9 5 6.8 0.0 2.6 3 0 0 3 3 3 0 26S proteasome subunit RPN7 IGR PF09597.10 EFC48938.1 - 2.2e-25 88.5 1.1 7.8e-25 86.7 0.6 2.0 2 0 0 2 2 2 1 IGR protein motif TerB_N PF13208.6 EFC48938.1 - 0.02 14.6 0.4 0.034 13.9 0.1 1.5 2 0 0 2 2 2 0 TerB N-terminal domain WD40 PF00400.32 EFC48939.1 - 4.3e-06 27.4 3.1 0.11 13.4 0.1 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat DUF2415 PF10313.9 EFC48939.1 - 0.0015 18.4 0.2 0.0053 16.7 0.1 2.1 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 EFC48939.1 - 0.024 14.9 0.0 2.8 8.3 0.0 3.4 2 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PLDc_3 PF13918.6 EFC48940.1 - 2.3e-29 102.3 0.7 1.5e-27 96.4 0.2 2.7 2 1 0 2 2 2 2 PLD-like domain PLDc_2 PF13091.6 EFC48940.1 - 6.4e-25 87.6 2.1 4.8e-15 55.6 0.1 2.5 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EFC48940.1 - 2.7e-09 36.8 0.4 1.5e-05 25.0 0.2 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif Oscp1 PF10188.9 EFC48941.1 - 3.2e-67 226.0 8.8 4.9e-67 225.4 8.8 1.3 1 0 0 1 1 1 1 Organic solute transport protein 1 Capsid_NCLDV PF04451.12 EFC48941.1 - 0.0075 16.1 1.6 0.012 15.5 1.5 1.3 1 1 0 1 1 1 1 Large eukaryotic DNA virus major capsid protein EF-hand_13 PF17958.1 EFC48941.1 - 0.1 12.4 0.5 0.49 10.2 0.2 2.2 2 0 0 2 2 2 0 EF-hand domain F-box PF00646.33 EFC48941.1 - 0.18 11.7 1.3 0.89 9.5 0.1 2.6 3 0 0 3 3 3 0 F-box domain DUF1002 PF06207.11 EFC48941.1 - 0.47 10.0 0.0 0.47 10.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1002) FUR PF01475.19 EFC48941.1 - 0.81 9.8 5.3 0.3 11.2 2.3 2.0 2 0 0 2 2 2 0 Ferric uptake regulator family Cpn60_TCP1 PF00118.24 EFC48942.1 - 4e-96 322.6 3.6 4.9e-96 322.3 3.6 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family YBD PF17725.1 EFC48942.1 - 0.01 15.7 1.0 0.025 14.5 1.0 1.6 1 0 0 1 1 1 0 YAP binding domain PNP_UDP_1 PF01048.20 EFC48943.1 - 1.9e-41 141.9 0.0 2.3e-41 141.6 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily Myotub-related PF06602.14 EFC48944.1 - 6.5e-144 479.2 3.5 9.6e-144 478.6 3.5 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 EFC48944.1 - 3.6e-06 26.7 0.1 1.1e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 EFC48944.1 - 0.00034 20.4 0.2 0.0015 18.3 0.2 2.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 EFC48944.1 - 0.00073 19.6 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family PGM_PMM_III PF02880.16 EFC48945.1 - 1e-30 106.3 0.0 1.3e-29 102.7 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_I PF02878.16 EFC48945.1 - 4.1e-28 97.8 0.0 8.3e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 EFC48945.1 - 1e-15 58.2 0.1 2.3e-15 57.1 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 EFC48945.1 - 0.0078 16.4 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Dynamin_M PF01031.20 EFC48946.1 - 5.5e-100 334.3 0.9 5.5e-100 334.3 0.9 2.1 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 EFC48946.1 - 1.9e-56 190.7 0.4 1.9e-56 190.7 0.4 2.0 3 0 0 3 3 3 1 Dynamin family GED PF02212.18 EFC48946.1 - 2.8e-27 94.7 5.2 2.8e-27 94.7 5.2 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFC48946.1 - 0.00017 21.6 1.3 0.00041 20.4 0.2 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC48946.1 - 0.028 14.0 0.4 3.6 7.1 0.2 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_16 PF13191.6 EFC48946.1 - 0.12 12.8 0.1 0.62 10.4 0.0 2.2 3 0 0 3 3 3 0 AAA ATPase domain GDPD_2 PF13653.6 EFC48946.1 - 0.12 12.8 0.0 0.41 11.2 0.0 1.9 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family DUF445 PF04286.12 EFC48946.1 - 1.2 8.8 9.4 0.27 11.0 2.3 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF445) SUIM_assoc PF16619.5 EFC48946.1 - 2.7 8.1 6.8 0.96 9.6 0.2 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Fcf2 PF08698.11 EFC48947.1 - 1.7e-24 86.0 0.4 1.7e-24 86.0 0.4 2.7 3 1 0 3 3 3 1 Fcf2 pre-rRNA processing AKNA PF12443.8 EFC48947.1 - 0.22 12.2 0.4 0.22 12.2 0.4 3.2 4 0 0 4 4 4 0 AT-hook-containing transcription factor Glyco_transf_18 PF15024.6 EFC48948.1 - 4.1e-10 38.9 11.0 4.1e-10 38.9 11.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 18 DUF966 PF06136.13 EFC48949.1 - 0.038 13.7 15.3 0.045 13.5 15.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Utp14 PF04615.13 EFC48949.1 - 0.083 11.5 12.5 0.095 11.3 12.5 1.1 1 0 0 1 1 1 0 Utp14 protein Macoilin PF09726.9 EFC48949.1 - 4.7 5.6 21.7 6.4 5.2 21.7 1.1 1 0 0 1 1 1 0 Macoilin family UPF0020 PF01170.18 EFC48950.1 - 1.6e-08 34.5 0.0 1.5e-07 31.3 0.0 2.1 1 1 1 2 2 2 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 EFC48950.1 - 0.034 13.4 0.0 0.13 11.5 0.0 1.9 1 1 0 1 1 1 0 N-6 DNA Methylase N6_N4_Mtase PF01555.18 EFC48950.1 - 0.038 13.7 0.1 0.62 9.7 0.0 2.5 3 0 0 3 3 3 0 DNA methylase RNase_T PF00929.24 EFC48952.1 - 3.4e-32 112.3 0.2 3.9e-32 112.1 0.2 1.0 1 0 0 1 1 1 1 Exonuclease Myb_DNA-binding PF00249.31 EFC48953.1 - 7.1e-08 32.5 0.2 1.3e-07 31.7 0.2 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain eIF3_p135 PF12807.7 EFC48953.1 - 0.24 11.4 2.4 0.44 10.6 2.4 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 HD_3 PF13023.6 EFC48954.1 - 3.5e-52 176.6 0.4 4.2e-52 176.4 0.4 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 EFC48954.1 - 7.8e-11 42.0 0.7 1.2e-10 41.5 0.7 1.3 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 EFC48954.1 - 0.0041 17.3 0.0 0.0064 16.7 0.0 1.3 1 0 0 1 1 1 1 HD domain SPT6_acidic PF14632.6 EFC48955.1 - 0.038 14.6 17.9 0.038 14.6 17.9 6.2 2 2 3 5 5 5 0 Acidic N-terminal SPT6 MT-A70 PF05063.14 EFC48956.1 - 2.5e-36 125.2 0.1 3.3e-36 124.8 0.1 1.2 1 0 0 1 1 1 1 MT-A70 ZZ PF00569.17 EFC48956.1 - 2.2e-12 46.6 60.3 8.6e-07 28.7 10.5 5.2 4 1 0 4 4 4 3 Zinc finger, ZZ type N6_N4_Mtase PF01555.18 EFC48956.1 - 0.017 14.9 0.4 0.028 14.1 0.4 1.4 1 0 0 1 1 1 0 DNA methylase HA2 PF04408.23 EFC48957.1 - 1.2e-25 89.9 0.0 2.7e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFC48957.1 - 8e-24 83.8 0.0 1.6e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 EFC48957.1 - 1.6e-12 47.7 0.0 3.3e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ANAPC4_WD40 PF12894.7 EFC48958.1 - 0.014 15.7 0.0 1.4 9.3 0.0 2.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 EFC48959.1 - 1.1e-51 175.7 3.7 3.5e-36 124.9 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48959.1 - 1.1e-28 100.3 0.2 1.7e-28 99.6 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC48959.1 - 1.3e-06 28.0 0.0 7.2e-06 25.5 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 EFC48959.1 - 0.00022 20.1 1.6 0.00057 18.8 1.6 1.7 1 1 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 EFC48959.1 - 0.033 13.3 0.2 0.85 8.6 0.0 2.2 2 0 0 2 2 2 0 Seadornavirus VP7 DUF5601 PF18151.1 EFC48960.1 - 0.077 13.3 1.5 2.9 8.3 0.1 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5601) AMP-binding PF00501.28 EFC48961.1 - 8.8e-78 261.8 0.0 1.1e-77 261.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC48961.1 - 2.1e-18 67.1 0.2 4.2e-18 66.1 0.2 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SpoU_sub_bind PF08032.12 EFC48961.1 - 0.0091 16.3 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Mito_carr PF00153.27 EFC48962.1 - 1.3e-40 137.2 6.9 2.5e-17 62.6 0.4 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Aminotran_5 PF00266.19 EFC48963.1 - 7.6e-08 31.7 0.0 7e-07 28.5 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V Kelch_4 PF13418.6 EFC48964.1 - 2.3e-16 59.5 2.2 9.5e-07 28.7 0.0 6.8 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC48964.1 - 7.5e-15 54.8 0.2 1.5e-06 28.3 0.0 5.2 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC48964.1 - 1e-13 50.9 0.1 0.00054 19.9 0.0 5.8 6 0 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 EFC48964.1 - 1.6e-07 31.3 2.9 0.0015 18.8 0.0 5.5 6 1 1 7 7 7 1 Kelch motif BTB PF00651.31 EFC48964.1 - 2.6e-05 24.4 0.1 0.0002 21.5 0.0 2.4 2 0 0 2 2 2 1 BTB/POZ domain Kelch_1 PF01344.25 EFC48964.1 - 0.029 14.0 0.2 1.4 8.5 0.0 3.4 3 0 0 3 3 3 0 Kelch motif Hemerythrin PF01814.23 EFC48965.1 - 1.4e-10 41.9 0.7 4.3e-10 40.3 1.0 1.6 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain YBD PF17725.1 EFC48965.1 - 0.023 14.6 0.2 0.033 14.1 0.2 1.3 1 0 0 1 1 1 0 YAP binding domain IpaB_EvcA PF03278.13 EFC48965.1 - 0.031 14.0 2.7 0.24 11.1 0.1 2.5 3 0 0 3 3 3 0 IpaB/EvcA family Latarcin PF10279.9 EFC48965.1 - 0.073 13.5 1.5 0.17 12.3 1.5 1.6 1 0 0 1 1 1 0 Latarcin precursor DUF2939 PF11159.8 EFC48965.1 - 0.17 12.3 0.0 11 6.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2939) Peptidase_C2 PF00648.21 EFC48968.1 - 1.1e-77 261.0 0.1 1.7e-77 260.4 0.1 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease C2 PF00168.30 EFC48968.1 - 1.7e-19 70.0 0.0 6.4e-19 68.2 0.0 2.0 1 0 0 1 1 1 1 C2 domain Calpain_III PF01067.22 EFC48968.1 - 1e-13 51.8 0.7 2e-10 41.1 0.1 2.8 2 0 0 2 2 2 2 Calpain large subunit, domain III N6_N4_Mtase PF01555.18 EFC48968.1 - 0.058 13.1 1.1 0.13 11.9 1.1 1.6 1 0 0 1 1 1 0 DNA methylase Transposase_22 PF02994.14 EFC48968.1 - 0.07 13.3 0.1 0.3 11.3 0.1 2.1 1 0 0 1 1 1 0 L1 transposable element RBD-like domain N6-adenineMlase PF10237.9 EFC48969.1 - 3.8e-37 127.5 2.5 4.4e-37 127.3 2.5 1.0 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase Cons_hypoth95 PF03602.15 EFC48969.1 - 0.19 11.3 0.1 0.25 11.0 0.1 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 BTB PF00651.31 EFC48970.1 - 7.2e-17 61.6 0.8 1.5e-16 60.6 0.8 1.6 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 EFC48970.1 - 1.3e-05 25.2 1.9 5.7e-05 23.1 0.2 2.4 2 1 0 2 2 2 1 BTB And C-terminal Kelch zf-C3HC4_3 PF13920.6 EFC48971.1 - 7.8e-08 32.1 12.8 1.3e-07 31.4 12.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC48971.1 - 8e-07 29.3 15.7 1.4e-06 28.5 15.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 EFC48971.1 - 0.00016 21.9 9.7 0.00038 20.7 9.7 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 EFC48971.1 - 0.0013 18.6 17.3 0.0023 17.8 17.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC48971.1 - 0.0055 16.6 13.0 0.0096 15.8 13.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 EFC48971.1 - 0.036 13.9 15.8 0.065 13.1 15.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFC48971.1 - 0.084 12.9 6.8 0.2 11.7 6.8 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 EFC48971.1 - 0.32 11.2 10.8 0.12 12.5 8.0 1.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_5 PF14634.6 EFC48971.1 - 0.83 9.7 15.4 2.4 8.2 15.5 1.7 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFC48971.1 - 5.8 7.2 14.7 12 6.2 14.7 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Peptidase_C2 PF00648.21 EFC48973.1 - 8.9e-65 218.6 0.0 3.5e-60 203.5 0.0 2.1 2 0 0 2 2 2 2 Calpain family cysteine protease BHD_3 PF10405.9 EFC48974.1 - 4e-21 75.2 0.0 9e-21 74.1 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 Nop14 PF04147.12 EFC48974.1 - 0.012 13.9 21.4 0.018 13.3 21.4 1.3 1 0 0 1 1 1 0 Nop14-like family BHD_2 PF10404.9 EFC48974.1 - 0.036 15.0 0.1 0.036 15.0 0.1 3.4 2 1 0 2 2 1 0 Rad4 beta-hairpin domain 2 CCD48 PF15799.5 EFC48974.1 - 0.097 11.0 4.8 0.12 10.7 4.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 DNA_pol_phi PF04931.13 EFC48974.1 - 0.15 10.1 15.6 0.21 9.6 15.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi Macoilin PF09726.9 EFC48974.1 - 0.26 9.8 14.9 0.38 9.3 14.9 1.2 1 0 0 1 1 1 0 Macoilin family DUF4551 PF15087.6 EFC48974.1 - 0.41 9.4 11.9 0.58 8.9 11.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.14 EFC48974.1 - 0.52 8.6 19.6 0.74 8.0 19.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 EFC48974.1 - 3.3 5.7 15.3 4.9 5.2 15.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SDA1 PF05285.12 EFC48974.1 - 4 6.8 31.7 0.014 14.8 22.3 1.7 2 0 0 2 2 2 0 SDA1 Neur_chan_memb PF02932.16 EFC48974.1 - 8.3 6.4 6.9 14 5.6 6.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region G-alpha PF00503.20 EFC48975.1 - 3.3e-111 371.9 8.8 4e-111 371.6 8.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC48975.1 - 2.1e-11 43.6 0.2 8.3e-08 31.9 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC48975.1 - 0.00037 20.6 0.1 0.46 10.6 0.0 2.5 2 1 0 2 2 2 2 50S ribosome-binding GTPase SRPRB PF09439.10 EFC48975.1 - 0.0032 16.9 0.2 1.2 8.6 0.0 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC48975.1 - 0.0039 16.6 3.7 0.04 13.3 0.2 2.4 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC48975.1 - 0.0084 16.3 0.1 0.42 10.9 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PPS_PS PF02006.16 EFC48975.1 - 0.033 13.8 0.5 3.6 7.1 0.1 2.3 1 1 1 2 2 2 0 Phosphopantothenate/pantothenate synthetase Ras PF00071.22 EFC48975.1 - 0.044 13.4 0.7 3.9 7.0 0.0 2.9 2 1 0 2 2 2 0 Ras family TniB PF05621.11 EFC48975.1 - 0.056 12.9 0.1 1.1 8.6 0.1 2.4 1 1 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 EFC48975.1 - 0.069 13.7 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 EFC48975.1 - 0.079 12.3 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 EFC48975.1 - 0.11 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 EFC48976.1 - 7e-16 58.3 17.2 0.023 15.6 1.2 8.1 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC48976.1 - 0.00019 21.6 0.2 0.17 12.2 0.0 4.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Telomere_reg-2 PF10193.9 EFC48976.1 - 0.0075 16.7 1.7 0.036 14.5 0.4 2.8 4 0 0 4 4 4 1 Telomere length regulation protein F-box-like PF12937.7 EFC48977.1 - 0.0013 18.6 0.1 0.0031 17.4 0.0 1.7 2 0 0 2 2 2 1 F-box-like PIEZO PF15917.5 EFC48977.1 - 0.012 15.1 0.3 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Piezo Sporozoite_P67 PF05642.11 EFC48977.1 - 4.5 5.2 6.3 6.8 4.6 6.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PQ-loop PF04193.14 EFC48980.1 - 2.5e-24 84.8 6.9 2.4e-15 56.0 1.5 2.7 2 1 1 3 3 3 2 PQ loop repeat DUF2368 PF10166.9 EFC48980.1 - 0.072 12.7 0.2 0.072 12.7 0.2 1.5 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) zf-RING_4 PF14570.6 EFC48982.1 - 3.2e-19 68.5 17.0 6.1e-19 67.5 17.0 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 EFC48982.1 - 1.9e-06 27.6 12.5 3.2e-06 26.9 12.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 EFC48982.1 - 0.001 18.9 0.2 0.0056 16.5 0.2 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RING_2 PF13639.6 EFC48982.1 - 0.0043 17.3 17.3 0.008 16.5 17.3 1.5 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 EFC48982.1 - 0.005 16.7 5.8 0.005 16.7 5.8 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-CCCH_2 PF14608.6 EFC48982.1 - 0.0067 16.9 1.4 0.018 15.5 1.4 1.8 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 EFC48982.1 - 0.013 16.2 0.0 0.013 16.2 0.0 3.6 3 0 0 3 3 3 0 Torus domain zinc_ribbon_2 PF13240.6 EFC48982.1 - 0.041 13.6 0.7 0.041 13.6 0.7 2.8 2 0 0 2 2 2 0 zinc-ribbon domain NARP1 PF12569.8 EFC48982.1 - 0.31 9.9 8.2 0.95 8.3 8.2 1.8 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rtf2 PF04641.12 EFC48982.1 - 0.46 9.8 21.8 1.9 7.8 9.4 2.5 2 0 0 2 2 2 0 Rtf2 RING-finger Ureide_permease PF07168.11 EFC48982.1 - 1.6 7.4 2.7 3 6.5 2.7 1.4 1 0 0 1 1 1 0 Ureide permease Ferlin_C PF16165.5 EFC48982.1 - 2.4 8.1 10.6 0.86 9.5 4.3 2.4 2 0 0 2 2 2 0 Ferlin C-terminus zf-C3HC4_2 PF13923.6 EFC48982.1 - 5.2 7.0 16.1 9.2 6.2 16.1 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ATP-synt_E PF05680.12 EFC48982.1 - 5.5 7.4 11.2 10 6.6 0.1 2.8 2 0 0 2 2 2 0 ATP synthase E chain GTP_EFTU PF00009.27 EFC48983.1 - 6.7e-33 113.9 0.1 1e-32 113.3 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 EFC48983.1 - 1.8e-18 66.4 0.0 3.8e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 EFC48983.1 - 8.4e-16 57.8 0.0 1.8e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 EFC48983.1 - 4e-05 23.9 0.0 8.8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 EFC48983.1 - 8e-05 22.7 0.0 0.00022 21.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II DUF4347 PF14252.6 EFC48983.1 - 0.01 15.7 0.1 0.051 13.4 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4347) MMR_HSR1 PF01926.23 EFC48983.1 - 0.022 14.8 0.1 0.054 13.6 0.1 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_31 PF13614.6 EFC48983.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.7 1 0 0 1 1 1 0 AAA domain Tektin PF03148.14 EFC48984.1 - 0.0045 15.8 1.2 0.0084 14.9 1.2 1.4 1 0 0 1 1 1 1 Tektin family HTH_37 PF13744.6 EFC48985.1 - 0.029 14.3 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain PPTA PF01239.22 EFC48985.1 - 0.11 12.3 1.9 1.4 8.8 0.1 2.9 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat DUF3950 PF13132.6 EFC48985.1 - 0.12 12.1 1.1 12 5.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) RGS PF00615.19 EFC48986.1 - 0.00012 22.4 9.7 0.00022 21.5 5.1 3.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain DUF2700 PF10912.8 EFC48986.1 - 0.073 13.1 0.3 0.073 13.1 0.3 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2700) DUF4441 PF14536.6 EFC48986.1 - 5 7.3 18.3 1.1 9.4 3.5 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) RGS PF00615.19 EFC48987.1 - 4.2e-07 30.2 2.9 2.3e-06 27.9 2.9 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC48987.1 - 0.011 15.5 0.7 0.013 15.2 0.7 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain Cas_TM1802 PF09484.10 EFC48987.1 - 0.014 14.2 3.2 0.016 14.0 3.2 1.1 1 0 0 1 1 1 0 CRISPR-associated protein TM1802 (cas_TM1802) HECT PF00632.25 EFC48988.1 - 2e-79 267.3 2.5 7.1e-78 262.2 0.4 2.4 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) DUF3337 PF11816.8 EFC48988.1 - 0.031 14.2 0.0 0.031 14.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3337) HEAT_2 PF13646.6 EFC48988.1 - 0.041 14.3 0.2 20 5.6 0.0 4.1 4 0 0 4 4 4 0 HEAT repeats HEAT_EZ PF13513.6 EFC48988.1 - 0.12 13.0 0.1 5.4 7.6 0.1 3.5 3 0 0 3 3 3 0 HEAT-like repeat Sec7_N PF12783.7 EFC48988.1 - 1.2 9.0 6.0 23 4.9 0.6 3.9 3 1 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Pkinase PF00069.25 EFC48989.1 - 1.5e-61 208.1 0.9 1.1e-43 149.5 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC48989.1 - 7.7e-38 130.3 0.3 1.2e-37 129.6 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC48989.1 - 5.9e-05 22.5 0.0 0.00014 21.3 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC48989.1 - 0.0039 16.0 0.0 0.0053 15.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 EFC48989.1 - 0.0098 15.5 1.0 1.2 8.7 0.1 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 EFC48989.1 - 0.013 14.6 1.3 0.021 13.9 0.1 1.9 2 0 0 2 2 2 0 Seadornavirus VP7 Dioxygenase_C PF00775.21 EFC48990.1 - 1.4e-06 27.9 0.3 1.4e-05 24.6 0.3 2.1 1 1 0 1 1 1 1 Dioxygenase Proteasome PF00227.26 EFC48991.1 - 3.8e-57 192.9 0.1 4.5e-57 192.6 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFC48991.1 - 3.8e-15 55.2 0.0 1.5e-14 53.4 0.0 2.1 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Abhydrolase_1 PF00561.20 EFC48992.1 - 1.8e-12 47.5 0.7 5.1e-07 29.6 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 EFC48992.1 - 1.1e-09 37.9 0.3 1.2e-07 31.2 0.1 2.9 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC48992.1 - 1.4e-09 38.9 0.0 2.1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 EFC48992.1 - 0.00026 20.6 0.4 0.0015 18.1 0.4 2.2 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 EFC48992.1 - 0.028 14.1 2.0 0.068 12.9 0.2 2.3 2 1 1 3 3 3 0 PGAP1-like protein Uteroglobin PF01099.17 EFC48992.1 - 0.08 13.3 0.2 11 6.5 0.0 2.7 2 0 0 2 2 2 0 Uteroglobin family LRR_8 PF13855.6 EFC48994.1 - 5.4e-11 42.1 13.7 8.9e-08 31.8 1.7 3.2 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC48994.1 - 3.3e-08 33.7 21.9 1e-06 28.9 1.7 3.9 3 2 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC48994.1 - 0.0021 18.3 19.6 3 8.7 0.1 6.0 6 0 0 6 6 6 3 Leucine Rich Repeat LRR_9 PF14580.6 EFC48994.1 - 0.086 12.3 4.9 0.14 11.6 1.6 2.2 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 EFC48994.1 - 0.86 9.8 0.0 0.86 9.8 0.0 4.4 6 0 0 6 6 6 0 Leucine Rich repeat EMP24_GP25L PF01105.24 EFC48995.1 - 7.8e-46 156.3 0.5 1.1e-45 155.8 0.5 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pox_RNA_pol PF03293.14 EFC48995.1 - 0.039 13.7 0.4 0.092 12.5 0.1 1.7 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase, 18 kD subunit Hemerythrin PF01814.23 EFC48996.1 - 0.0069 17.0 12.5 0.017 15.7 8.8 2.4 1 1 1 2 2 2 1 Hemerythrin HHE cation binding domain Herpes_UL92 PF03048.14 EFC48996.1 - 0.15 11.8 0.8 0.24 11.1 0.8 1.3 1 0 0 1 1 1 0 UL92 family SecA_DEAD PF07517.14 EFC48996.1 - 0.38 10.0 3.3 0.62 9.3 2.0 1.9 1 1 1 2 2 2 0 SecA DEAD-like domain GTP_EFTU PF00009.27 EFC48996.1 - 0.42 10.1 3.0 0.78 9.3 2.5 1.7 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain zf-C4H2 PF10146.9 EFC48996.1 - 0.64 10.3 6.9 1.1 9.5 6.9 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein RNase_H PF00075.24 EFC48996.1 - 5.1 7.3 7.2 0.94 9.7 2.6 2.2 2 1 0 2 2 2 0 RNase H AAA_assoc_C PF09821.9 EFC48996.1 - 8.2 7.0 11.5 16 6.1 0.1 3.4 2 1 1 4 4 4 0 C-terminal AAA-associated domain KTI12 PF08433.10 EFC48997.1 - 2.1e-16 60.2 3.6 2.8e-16 59.8 3.6 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 EFC48997.1 - 2.2e-09 37.6 0.0 1.1e-08 35.4 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 EFC48997.1 - 4.8e-08 33.5 0.7 1e-05 26.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain 6PF2K PF01591.18 EFC48997.1 - 1.1e-07 31.4 0.6 1.1e-07 31.4 0.6 1.6 1 1 0 1 1 1 1 6-phosphofructo-2-kinase AAA_18 PF13238.6 EFC48997.1 - 9.8e-07 29.4 1.4 4.1e-06 27.4 0.1 2.1 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 EFC48997.1 - 6.6e-05 22.9 0.0 0.00015 21.7 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase CPT PF07931.12 EFC48997.1 - 0.00018 21.4 0.0 0.00034 20.5 0.0 1.4 1 1 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 EFC48997.1 - 0.024 15.0 0.0 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 EFC48997.1 - 0.057 12.7 0.0 0.19 11.0 0.0 1.8 1 0 0 1 1 1 0 Zeta toxin HI0933_like PF03486.14 EFC48997.1 - 0.065 11.9 3.5 0.13 10.9 3.5 1.4 1 0 0 1 1 1 0 HI0933-like protein AAA PF00004.29 EFC48997.1 - 0.18 12.2 1.3 0.24 11.8 0.1 1.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) zf-RING_10 PF16685.5 EFC48997.1 - 4.9 7.4 8.3 0.96 9.6 1.2 2.7 3 0 0 3 3 3 0 zinc RING finger of MSL2 Skp1 PF01466.19 EFC48998.1 - 2.8e-25 88.2 0.2 3.4e-25 87.9 0.2 1.1 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Myb_DNA-binding PF00249.31 EFC48998.1 - 0.058 13.6 0.2 7.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain Beta-lactamase PF00144.24 EFC48999.1 - 2.7e-19 69.6 0.0 8.6e-19 67.9 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase Mon1 PF03164.14 EFC49000.1 - 3e-107 359.2 13.9 3.4e-107 359.0 13.9 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Clat_adaptor_s PF01217.20 EFC49000.1 - 0.0045 16.9 0.1 0.012 15.6 0.1 1.7 1 0 0 1 1 1 1 Clathrin adaptor complex small chain ETRAMP PF09716.10 EFC49002.1 - 0.028 14.5 0.1 0.58 10.3 0.1 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) MRAP PF15183.6 EFC49002.1 - 0.03 14.3 0.5 0.091 12.7 0.1 1.9 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family DUF4834 PF16118.5 EFC49002.1 - 0.14 13.1 0.5 1 10.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Zip PF02535.22 EFC49002.1 - 0.21 10.8 3.9 9.6 5.3 0.0 2.6 2 1 0 2 2 2 0 ZIP Zinc transporter FtsX PF02687.21 EFC49002.1 - 0.81 10.2 13.2 0.43 11.1 5.7 2.2 2 0 0 2 2 2 0 FtsX-like permease family Actin PF00022.19 EFC49003.1 - 2.5e-05 23.1 0.3 5.5e-05 22.0 0.0 1.6 2 0 0 2 2 2 1 Actin Tuberin PF03542.16 EFC49003.1 - 0.028 13.5 0.2 0.028 13.5 0.2 1.8 2 0 0 2 2 2 0 Tuberin DUF2826 PF11442.8 EFC49003.1 - 0.19 11.6 0.1 0.34 10.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) AAA_35 PF14516.6 EFC49004.1 - 0.00019 20.4 0.0 0.00034 19.6 0.0 1.4 1 1 0 1 1 1 1 AAA-like domain AAA PF00004.29 EFC49004.1 - 0.0016 18.8 0.0 0.0031 17.9 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EFC49004.1 - 0.0035 16.8 0.0 0.0061 16.0 0.0 1.3 1 1 0 1 1 1 1 Bacterial TniB protein AAA_16 PF13191.6 EFC49004.1 - 0.0036 17.7 0.1 0.052 13.9 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC49004.1 - 0.0039 17.5 0.0 0.0057 16.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain T4SS-DNA_transf PF02534.14 EFC49004.1 - 0.021 13.7 0.0 3.6 6.3 0.0 2.1 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer ATPase_2 PF01637.18 EFC49004.1 - 0.051 13.5 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 EFC49004.1 - 0.081 12.5 0.0 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 EFC49004.1 - 0.095 12.2 0.1 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 EFC49005.1 - 2e-05 25.1 0.0 5.5e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 EFC49005.1 - 0.012 15.8 0.1 0.048 13.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain KTI12 PF08433.10 EFC49005.1 - 0.015 14.8 0.3 0.042 13.3 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 EFC49005.1 - 0.017 15.2 0.0 0.048 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain BLOC1_2 PF10046.9 EFC49005.1 - 0.093 13.0 1.5 1 9.7 0.1 2.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 OCRE PF17780.1 EFC49008.1 - 0.001 19.0 2.0 4.8 7.3 0.0 4.2 4 1 0 4 4 4 2 OCRE domain Nnf1 PF03980.14 EFC49008.1 - 0.072 13.5 0.2 0.072 13.5 0.2 2.3 2 1 0 2 2 2 0 Nnf1 Sedlin_N PF04628.13 EFC49009.1 - 1.1e-30 106.4 0.9 1.3e-30 106.2 0.9 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 EFC49009.1 - 5.2e-05 23.2 0.3 6.4e-05 22.9 0.3 1.2 1 0 0 1 1 1 1 Sybindin-like family Itfg2 PF15907.5 EFC49011.1 - 3.5e-21 75.6 2.3 5.9e-12 45.3 0.9 3.1 3 0 0 3 3 3 3 Integrin-alpha FG-GAP repeat-containing protein 2 Snf7 PF03357.21 EFC49012.1 - 4.3e-14 52.5 11.0 8.8e-14 51.5 11.0 1.4 1 0 0 1 1 1 1 Snf7 TryThrA_C PF12319.8 EFC49012.1 - 0.052 13.0 13.9 0.11 11.9 2.3 2.7 2 0 0 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal HSCB_C PF07743.13 EFC49012.1 - 0.38 11.3 0.1 0.38 11.3 0.1 3.4 2 2 1 3 3 3 0 HSCB C-terminal oligomerisation domain GlyL_C PF12524.8 EFC49013.1 - 0.033 14.3 0.0 0.087 13.0 0.0 1.7 1 0 0 1 1 1 0 dsDNA virus glycoprotein L C terminal Pex24p PF06398.11 EFC49017.1 - 0.0063 15.6 0.4 0.2 10.6 0.1 2.1 1 1 1 2 2 2 2 Integral peroxisomal membrane peroxin SMP_2 PF10144.9 EFC49017.1 - 0.019 14.6 0.5 0.035 13.7 0.5 1.5 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin DASH_Dad1 PF08649.10 EFC49017.1 - 0.1 12.8 0.4 0.56 10.4 0.1 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad1 DUF2207 PF09972.9 EFC49017.1 - 0.33 9.7 3.6 0.53 9.0 3.4 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5623 PF18536.1 EFC49018.1 - 2.5 8.4 5.4 1.2 9.4 0.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5623) RRM_1 PF00076.22 EFC49019.1 - 1.8e-22 78.9 0.2 2.1e-22 78.7 0.2 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 EFC49019.1 - 6e-05 22.9 0.0 0.1 12.4 0.0 2.0 1 1 1 2 2 2 2 Rrp7 RRM-like N-terminal domain RRM_occluded PF16842.5 EFC49019.1 - 0.0044 16.9 0.0 0.0071 16.2 0.0 1.3 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 EFC49019.1 - 0.011 15.8 0.0 0.019 15.1 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif Limkain-b1 PF11608.8 EFC49019.1 - 0.072 13.2 0.1 0.15 12.2 0.1 1.6 1 1 0 1 1 1 0 Limkain b1 PHM7_cyt PF14703.6 EFC49019.1 - 0.17 12.1 0.0 5 7.3 0.0 2.0 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RPAP3_C PF13877.6 EFC49021.1 - 1e-16 61.2 1.7 1.2e-16 61.0 0.2 1.9 2 0 0 2 2 2 1 Potential Monad-binding region of RPAP3 TPR_1 PF00515.28 EFC49021.1 - 3.2e-15 55.2 0.4 2e-05 24.2 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49021.1 - 1.8e-13 49.5 3.0 3.1e-05 23.8 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49021.1 - 6.2e-09 35.4 4.7 0.0093 16.1 0.1 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49021.1 - 5.6e-06 25.9 0.2 0.00015 21.3 0.1 2.6 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 EFC49021.1 - 0.0064 16.8 0.1 3 8.2 0.0 3.4 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC49021.1 - 0.042 13.9 0.1 0.23 11.6 0.0 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49021.1 - 0.3 11.8 2.9 4.1 8.2 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_6 PF13516.6 EFC49022.1 - 2.9e-31 104.9 30.8 0.00045 20.1 0.0 9.9 11 0 0 11 11 11 7 Leucine Rich repeat LRR_4 PF12799.7 EFC49022.1 - 8.1e-16 57.9 36.0 0.0001 22.6 1.3 6.5 3 1 5 8 8 8 7 Leucine Rich repeats (2 copies) F-box PF00646.33 EFC49022.1 - 1.8e-09 37.2 0.9 5.1e-09 35.8 0.9 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC49022.1 - 2.5e-06 27.2 0.3 6.9e-06 25.9 0.3 1.6 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC49022.1 - 4.9e-06 26.4 24.0 2.3 9.1 0.3 8.9 9 1 0 9 9 8 1 Leucine Rich Repeat LRR_8 PF13855.6 EFC49022.1 - 2.9e-05 23.8 41.4 0.0065 16.2 8.5 7.6 3 3 2 5 5 5 3 Leucine rich repeat LRR_9 PF14580.6 EFC49022.1 - 8.5e-05 22.1 6.6 0.12 11.9 0.5 3.4 1 1 1 3 3 3 2 Leucine-rich repeat MethyTransf_Reg PF10119.9 EFC49022.1 - 0.00063 20.4 1.7 19 6.1 0.0 6.0 2 2 4 6 6 6 0 Predicted methyltransferase regulatory domain YjcQ PF09639.10 EFC49022.1 - 0.029 14.6 6.4 5.4 7.3 0.3 5.0 2 1 4 6 6 6 0 YjcQ protein Synapsin_N PF10581.9 EFC49022.1 - 0.029 14.3 0.6 12 5.9 0.0 4.8 6 0 0 6 6 6 0 Synapsin N-terminal F-box_5 PF18511.1 EFC49022.1 - 0.093 12.3 0.1 0.2 11.2 0.1 1.6 1 0 0 1 1 1 0 F-box EF-hand_1 PF00036.32 EFC49023.1 - 3.3e-11 41.9 6.3 4.1e-06 26.0 0.1 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 EFC49023.1 - 1e-09 38.7 3.7 2.1e-05 24.9 0.6 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFC49023.1 - 7.7e-08 32.1 4.5 0.00094 19.0 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC49023.1 - 1e-07 31.3 2.3 6.3e-05 22.6 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain TerB PF05099.13 EFC49023.1 - 0.00015 21.7 0.4 0.015 15.2 0.1 2.2 2 0 0 2 2 2 1 Tellurite resistance protein TerB EF-hand_5 PF13202.6 EFC49023.1 - 0.0013 18.1 0.1 0.0013 18.1 0.1 3.0 4 0 0 4 4 4 1 EF hand EF-hand_11 PF08976.11 EFC49023.1 - 0.0025 18.7 0.1 0.0036 18.2 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_4 PF12763.7 EFC49023.1 - 0.021 14.8 1.9 0.44 10.5 0.2 2.3 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand SinI PF08671.10 EFC49023.1 - 0.04 13.7 4.0 0.39 10.6 2.4 2.8 2 0 0 2 2 2 0 Anti-repressor SinI Mrr_N PF14338.6 EFC49023.1 - 0.048 13.8 0.1 0.12 12.5 0.0 1.8 2 0 0 2 2 2 0 Mrr N-terminal domain F-box-like PF12937.7 EFC49024.1 - 1.4e-06 28.0 0.6 3e-06 27.0 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC49024.1 - 7e-05 22.6 0.6 0.00014 21.6 0.6 1.6 1 0 0 1 1 1 1 F-box domain DUF389 PF04087.14 EFC49024.1 - 0.48 10.5 6.2 0.51 10.4 0.3 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF389) CUE PF02845.16 EFC49025.1 - 1.1e-05 25.1 0.1 2.8e-05 23.7 0.1 1.8 1 0 0 1 1 1 1 CUE domain Pkinase PF00069.25 EFC49026.1 - 4.6e-48 163.9 0.4 9.3e-48 162.9 0.4 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49026.1 - 1.1e-47 162.6 0.1 2e-47 161.7 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 EFC49026.1 - 4.9e-09 36.3 0.1 8.8e-08 32.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFC49026.1 - 0.00012 22.3 1.5 0.00037 20.8 0.5 2.4 2 0 0 2 2 2 1 Ankyrin repeat Pkinase_fungal PF17667.1 EFC49026.1 - 0.0003 19.7 0.1 0.0003 19.7 0.1 1.6 2 0 0 2 2 2 1 Fungal protein kinase Ank_3 PF13606.6 EFC49026.1 - 0.0027 18.1 0.1 0.017 15.6 0.1 2.5 1 0 0 1 1 1 1 Ankyrin repeat APH PF01636.23 EFC49026.1 - 0.018 15.0 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family NrfD PF03916.14 EFC49026.1 - 0.1 12.2 0.1 0.18 11.4 0.1 1.3 1 0 0 1 1 1 0 Polysulphide reductase, NrfD SAM_Exu PF18609.1 EFC49026.1 - 0.13 12.3 0.6 0.46 10.6 0.6 2.0 1 0 0 1 1 1 0 Exuperantia SAM-like domain ALO PF04030.14 EFC49027.1 - 8.2e-78 261.8 2.1 1.3e-77 261.2 2.1 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 EFC49027.1 - 6.2e-26 90.8 0.1 8.9e-26 90.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain DUF4500 PF14937.6 EFC49027.1 - 0.047 13.7 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) TED_complement PF07678.14 EFC49027.1 - 0.12 11.4 0.1 0.96 8.4 0.0 2.0 2 0 0 2 2 2 0 A-macroglobulin TED domain Voltage_CLC PF00654.20 EFC49029.1 - 3.8e-55 187.6 25.4 3.8e-55 187.6 25.4 1.9 1 1 1 2 2 2 2 Voltage gated chloride channel His_Phos_2 PF00328.22 EFC49030.1 - 1.3e-12 47.8 0.5 9.5e-06 25.2 0.4 2.6 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) DTW PF03942.15 EFC49031.1 - 6.7e-07 29.2 7.7 7.9e-06 25.7 7.7 2.0 1 1 0 1 1 1 1 DTW domain DUF1877 PF08974.10 EFC49031.1 - 0.046 13.8 1.0 0.074 13.1 0.2 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1877) MMS1_N PF10433.9 EFC49032.1 - 9.2e-111 370.9 2.5 1.5e-110 370.1 2.5 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFC49032.1 - 1.2e-62 212.1 0.3 3.4e-62 210.6 0.1 1.9 2 0 0 2 2 2 1 CPSF A subunit region EcKinase PF02958.20 EFC49033.1 - 2.3e-14 53.4 0.0 3.8e-12 46.1 0.1 2.1 2 0 0 2 2 2 2 Ecdysteroid kinase DUF1679 PF07914.11 EFC49033.1 - 1.3e-07 30.9 0.1 1e-06 27.9 0.3 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) APH PF01636.23 EFC49033.1 - 6.2e-07 29.6 0.0 8.8e-07 29.1 0.0 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC49033.1 - 0.0063 16.1 0.3 0.011 15.4 0.3 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Na_H_Exchanger PF00999.21 EFC49034.1 - 1.2e-61 208.6 41.7 1.4e-61 208.4 41.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF2568 PF10823.8 EFC49034.1 - 2.1 8.7 7.9 1.5 9.2 0.1 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2568) Mon2_C PF16206.5 EFC49036.1 - 2.8e-32 111.8 11.1 4.5e-25 88.0 0.5 3.0 2 2 0 2 2 2 2 C-terminal region of Mon2 protein DCB PF16213.5 EFC49036.1 - 7.5e-22 77.8 16.0 2.8e-16 59.7 1.6 4.9 4 2 2 6 6 6 2 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 EFC49036.1 - 3.6e-17 62.7 3.5 3.6e-17 62.7 3.5 3.4 3 1 1 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 EFC49036.1 - 0.0019 18.0 0.0 0.0019 18.0 0.0 4.5 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Glycos_transf_2 PF00535.26 EFC49037.1 - 6.5e-29 100.9 0.0 1e-28 100.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFC49037.1 - 4.2e-08 33.4 0.0 1e-07 32.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 EFC49037.1 - 0.046 13.2 0.1 0.075 12.5 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 EFC49037.1 - 0.15 12.6 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 HH_signal PF01085.18 EFC49037.1 - 0.18 11.5 0.1 0.27 10.9 0.1 1.2 1 0 0 1 1 1 0 Hedgehog amino-terminal signalling domain PHB_acc_N PF07879.11 EFC49037.1 - 0.4 10.8 2.9 1.1 9.4 2.9 1.8 1 1 0 1 1 1 0 PHB/PHA accumulation regulator DNA-binding domain S6PP_C PF08472.10 EFC49038.1 - 0.021 14.7 1.3 3.6 7.5 0.0 3.6 3 1 1 4 4 4 0 Sucrose-6-phosphate phosphohydrolase C-terminal PCNA_N PF00705.18 EFC49039.1 - 1.8e-50 169.9 6.0 6.3e-50 168.1 4.1 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 EFC49039.1 - 1.2e-46 158.0 0.6 3.1e-45 153.5 0.1 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 EFC49039.1 - 1e-10 41.5 0.7 1.2e-10 41.3 0.7 1.1 1 0 0 1 1 1 1 Rad9 Phenol_hyd_sub PF06099.11 EFC49039.1 - 0.0056 16.7 0.5 0.79 9.8 0.0 3.0 4 0 0 4 4 4 1 Phenol hydroxylase subunit A_deamin PF02137.18 EFC49040.1 - 1.5e-62 212.0 2.6 1.9e-62 211.6 2.6 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain Hira PF07569.11 EFC49041.1 - 0.16 11.7 1.2 0.25 11.0 1.2 1.3 1 0 0 1 1 1 0 TUP1-like enhancer of split DEAD PF00270.29 EFC49042.1 - 5e-12 45.9 0.0 1.1e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC49042.1 - 0.0078 16.6 0.1 0.15 12.4 0.1 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ABC2_membrane PF01061.24 EFC49043.1 - 1.3e-25 90.1 21.3 2.2e-25 89.3 21.3 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 EFC49043.1 - 6.5e-11 42.9 0.1 1.7e-10 41.5 0.0 1.8 2 0 0 2 2 2 1 ABC transporter PDR_CDR PF06422.12 EFC49043.1 - 0.00093 19.1 0.6 0.0024 17.7 0.6 1.6 1 0 0 1 1 1 1 CDR ABC transporter MMR_HSR1 PF01926.23 EFC49043.1 - 0.0045 17.0 0.2 0.012 15.7 0.2 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC49043.1 - 0.01 15.6 0.2 0.021 14.6 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 EFC49043.1 - 0.013 15.4 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_ATPase PF09818.9 EFC49043.1 - 0.019 13.8 0.4 0.036 12.9 0.0 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_21 PF13304.6 EFC49043.1 - 0.025 14.4 6.1 0.027 14.3 0.2 3.0 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFC49043.1 - 0.046 14.0 0.5 15 5.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 EFC49043.1 - 0.24 11.1 5.4 0.54 9.9 5.4 1.8 1 1 0 1 1 1 0 AAA ATPase domain Rpp20 PF12328.8 EFC49043.1 - 0.93 9.4 2.4 0.63 10.0 0.1 1.8 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P TrkH PF02386.16 EFC49044.1 - 7.5e-41 140.1 15.1 1.5e-38 132.5 15.2 2.9 2 1 0 2 2 2 2 Cation transport protein DUF5420 PF17457.2 EFC49045.1 - 0.063 13.1 0.0 0.16 11.8 0.0 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5420) DUF3149 PF11346.8 EFC49046.1 - 0.0018 17.8 1.6 0.0069 16.0 1.6 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3149) fn3_5 PF06280.12 EFC49046.1 - 0.04 14.6 0.3 0.095 13.4 0.0 1.8 2 0 0 2 2 2 0 Fn3-like domain FAA_hydrolase PF01557.18 EFC49047.1 - 0.14 11.9 0.1 1.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Fumarylacetoacetate (FAA) hydrolase family WD40 PF00400.32 EFC49048.1 - 1e-12 48.3 8.7 0.00044 21.0 0.2 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat eIF2A PF08662.11 EFC49048.1 - 1.2e-05 25.3 1.3 0.025 14.4 0.0 3.2 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EFC49048.1 - 0.00015 22.0 0.1 1 9.7 0.0 4.0 2 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC49048.1 - 0.0005 19.5 0.5 0.0071 15.7 0.2 2.3 2 1 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 EFC49048.1 - 0.00091 18.0 3.0 0.0025 16.5 0.2 2.2 1 1 0 2 2 2 1 Nucleoporin Nup120/160 RNase_P_Rpp14 PF01900.19 EFC49048.1 - 0.026 14.8 0.0 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 Rpp14/Pop5 family Ge1_WD40 PF16529.5 EFC49048.1 - 0.1 11.5 1.4 3.3 6.6 0.6 2.7 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L27 PF01016.19 EFC49049.1 - 1.7e-27 95.3 0.3 1.8e-27 95.1 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L27 protein E1-E2_ATPase PF00122.20 EFC49050.1 - 6.3e-44 149.6 0.1 6.3e-44 149.6 0.1 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFC49050.1 - 3.6e-38 131.1 8.0 3.6e-38 131.1 8.0 2.7 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFC49050.1 - 3.6e-22 79.7 0.0 6.4e-20 72.3 0.0 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC49050.1 - 6.9e-19 67.7 0.0 1.3e-18 66.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC49050.1 - 7.5e-14 51.2 0.0 1.6e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC49050.1 - 7.4e-06 25.9 1.1 0.0065 16.2 0.3 2.7 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 EFC49050.1 - 0.013 15.3 0.4 0.24 11.2 0.0 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) HAD PF12710.7 EFC49050.1 - 0.072 13.5 0.0 0.26 11.7 0.0 1.8 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Homeobox_KN PF05920.11 EFC49051.1 - 9.6e-19 67.0 0.3 3e-18 65.4 0.3 1.9 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC49051.1 - 9.9e-08 31.7 0.6 2.1e-07 30.7 0.6 1.6 1 0 0 1 1 1 1 Homeodomain adh_short PF00106.25 EFC49052.1 - 2e-37 128.5 0.0 2.5e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC49052.1 - 4.7e-25 88.5 0.0 6.6e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFC49052.1 - 1.9e-06 27.5 0.1 4.9e-06 26.2 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 EFC49052.1 - 1.8e-05 24.7 0.0 2.6e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 EFC49052.1 - 0.00028 20.0 0.1 0.00048 19.2 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 EFC49052.1 - 0.00061 19.3 0.0 0.00094 18.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC49052.1 - 0.00066 18.9 0.1 0.0012 18.0 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 EFC49052.1 - 0.0026 17.7 0.0 0.0074 16.2 0.1 1.6 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 EFC49052.1 - 0.0075 15.4 0.1 0.011 14.8 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain FtsJ PF01728.19 EFC49052.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 EFC49052.1 - 0.013 15.2 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_4 PF07993.12 EFC49052.1 - 0.017 14.3 0.2 0.073 12.2 0.2 2.1 1 1 0 1 1 1 0 Male sterility protein NmrA PF05368.13 EFC49052.1 - 0.02 14.4 0.1 0.032 13.8 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family Sacchrp_dh_NADP PF03435.18 EFC49052.1 - 0.027 14.8 0.1 0.049 13.9 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 EFC49052.1 - 0.037 13.4 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 EFC49052.1 - 0.098 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Tox-HDC PF15656.6 EFC49052.1 - 0.14 12.4 0.1 0.58 10.4 0.0 2.1 1 1 1 2 2 2 0 Toxin with a H, D/N and C signature NAGPA PF09992.9 EFC49053.1 - 1.6e-41 142.3 0.2 2.6e-41 141.6 0.2 1.4 1 0 0 1 1 1 1 Phosphodiester glycosidase Tetraspanin PF00335.20 EFC49053.1 - 0.012 15.3 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 Tetraspanin family Shisa PF13908.6 EFC49053.1 - 0.019 15.2 0.2 0.049 13.9 0.2 1.6 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ETRAMP PF09716.10 EFC49053.1 - 0.047 13.8 0.2 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SIT PF15330.6 EFC49053.1 - 0.12 12.8 0.1 1.5 9.3 0.1 2.4 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Nkap_C PF06047.11 EFC49054.1 - 1.3e-43 147.2 2.3 1.3e-43 147.2 2.3 3.4 3 1 0 3 3 3 1 NF-kappa-B-activating protein C-terminal domain DUF938 PF06080.12 EFC49054.1 - 0.02 14.7 0.1 0.066 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF938) ExbD PF02472.16 EFC49054.1 - 1.7 8.8 7.4 7.7 6.7 7.4 2.3 1 1 0 1 1 1 0 Biopolymer transport protein ExbD/TolR TPR_12 PF13424.6 EFC49055.1 - 7.4e-10 39.0 6.4 0.0075 16.5 0.1 5.8 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49055.1 - 4.1e-08 33.0 0.8 4.4 7.9 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49055.1 - 1.8e-07 30.7 4.7 0.12 12.6 0.9 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49055.1 - 2.3e-07 30.5 10.0 0.083 13.2 0.7 6.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC49055.1 - 2.5e-07 30.9 0.1 0.024 15.4 0.1 4.6 4 2 1 5 5 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC49055.1 - 3.7e-07 29.8 1.2 0.17 11.8 0.0 5.6 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49055.1 - 1.8e-06 28.5 0.0 0.52 11.0 0.0 4.5 5 1 1 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49055.1 - 1.8e-06 27.5 3.1 0.46 10.4 1.3 5.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49055.1 - 1.1e-05 25.7 2.2 1.3 9.8 0.0 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49055.1 - 0.00018 22.0 0.7 5.4 7.6 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat FAT PF02259.23 EFC49055.1 - 0.0039 16.4 8.1 0.14 11.4 0.2 3.3 3 0 0 3 3 3 2 FAT domain NRDE-2 PF08424.10 EFC49055.1 - 0.03 13.5 0.6 0.088 11.9 0.0 1.9 2 0 0 2 2 2 0 NRDE-2, necessary for RNA interference TPR_20 PF14561.6 EFC49055.1 - 0.13 12.6 0.1 2.8 8.3 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat ADIP PF11559.8 EFC49055.1 - 0.36 10.9 0.0 0.36 10.9 0.0 3.1 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding MIT PF04212.18 EFC49055.1 - 0.38 10.8 2.1 4.4 7.4 0.0 3.7 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain SieB PF14163.6 EFC49055.1 - 0.48 9.9 2.7 0.75 9.3 0.1 2.6 3 1 0 3 3 3 0 Super-infection exclusion protein B THOC7 PF05615.13 EFC49055.1 - 2.3 8.5 5.5 20 5.5 0.2 3.3 4 0 0 4 4 4 0 Tho complex subunit 7 Tctex-1 PF03645.13 EFC49056.1 - 7.8e-25 87.1 0.0 8.6e-25 87.0 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family RNase_PH PF01138.21 EFC49057.1 - 2.7e-27 95.8 0.0 5.3e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFC49057.1 - 9.1e-14 51.2 0.1 1.8e-13 50.3 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Brr6_like_C_C PF10104.9 EFC49058.1 - 0.22 11.3 1.6 0.53 10.1 1.6 1.6 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Tweety PF04906.13 EFC49058.1 - 9 4.8 6.5 4.6 5.8 4.0 1.7 2 0 0 2 2 2 0 Tweety SQS_PSY PF00494.19 EFC49059.1 - 2.4e-37 128.9 0.0 3.2e-37 128.5 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase GTP_EFTU PF00009.27 EFC49060.1 - 6.4e-48 162.9 0.7 8.8e-47 159.2 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC49060.1 - 1.8e-17 63.7 0.8 4.1e-17 62.5 0.8 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC49060.1 - 1.8e-09 37.9 1.4 1.8e-09 37.9 1.4 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC49060.1 - 2.4e-07 30.8 4.0 0.0016 18.5 0.0 3.3 4 0 0 4 4 4 2 50S ribosome-binding GTPase SRPRB PF09439.10 EFC49060.1 - 0.012 15.1 0.0 1.1 8.7 0.0 2.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Arf PF00025.21 EFC49060.1 - 0.027 13.9 0.0 0.78 9.2 0.1 2.5 1 1 1 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 EFC49060.1 - 0.073 13.3 0.0 19 5.5 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MSP7_C PF12948.7 EFC49060.1 - 0.089 13.5 3.4 0.21 12.2 3.4 1.7 1 0 0 1 1 1 0 MSP7-like protein C-terminal domain Ras PF00071.22 EFC49060.1 - 0.16 11.5 1.7 1.9 8.1 0.0 2.8 2 1 1 3 3 3 0 Ras family Folliculin PF11704.8 EFC49061.1 - 0.0028 17.6 1.1 0.0042 17.0 1.1 1.3 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport MecA PF05389.12 EFC49061.1 - 0.005 16.5 3.5 0.0056 16.3 3.5 1.3 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) Umbravirus_LDM PF04817.12 EFC49061.1 - 0.0066 15.8 2.6 0.0091 15.4 2.6 1.1 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family Hid1 PF12722.7 EFC49061.1 - 0.0084 14.3 7.1 0.01 14.0 7.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Pex14_N PF04695.13 EFC49061.1 - 0.01 16.5 3.5 0.013 16.1 3.5 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RR_TM4-6 PF06459.12 EFC49061.1 - 0.022 14.6 7.8 0.028 14.2 7.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MMU163 PF17119.5 EFC49061.1 - 0.025 13.8 5.9 0.035 13.3 5.9 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis UBA_4 PF14555.6 EFC49061.1 - 0.034 14.0 0.0 0.41 10.5 0.0 2.5 2 0 0 2 2 2 0 UBA-like domain NPR3 PF03666.13 EFC49061.1 - 0.042 12.6 7.2 0.052 12.3 7.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_Rpc4 PF05132.14 EFC49061.1 - 0.059 13.8 3.5 0.11 12.9 3.5 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 CUE PF02845.16 EFC49061.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 CUE domain ELL PF10390.9 EFC49061.1 - 0.15 11.5 9.7 0.2 11.1 9.7 1.1 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL SLC12 PF03522.15 EFC49061.1 - 0.17 10.9 7.0 0.2 10.7 7.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 EFC49061.1 - 0.21 8.7 5.3 0.22 8.6 5.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RP-C_C PF11800.8 EFC49061.1 - 0.31 11.1 5.5 0.42 10.7 5.5 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region CDK2AP PF09806.9 EFC49061.1 - 0.37 10.8 10.0 0.55 10.3 10.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Striatin PF08232.12 EFC49061.1 - 0.42 11.2 11.0 0.71 10.4 11.0 1.3 1 0 0 1 1 1 0 Striatin family Podoplanin PF05808.11 EFC49061.1 - 0.5 10.5 6.3 0.77 9.9 6.3 1.2 1 0 0 1 1 1 0 Podoplanin KCNQ2_u3 PF16642.5 EFC49061.1 - 0.59 11.2 5.9 0.91 10.6 5.9 1.3 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 ATP11 PF06644.11 EFC49061.1 - 0.8 9.4 8.1 1.2 8.9 8.1 1.2 1 0 0 1 1 1 0 ATP11 protein FancD2 PF14631.6 EFC49061.1 - 0.82 7.0 7.1 1.1 6.6 7.1 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Presenilin PF01080.17 EFC49061.1 - 1.6 7.4 10.3 2.1 7.0 10.3 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 EFC49061.1 - 7.6 5.6 6.8 11 5.1 6.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 EFC49061.1 - 8.5 4.9 8.5 12 4.5 8.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Menin PF05053.13 EFC49061.1 - 9.7 4.4 10.5 12 4.1 10.5 1.1 1 0 0 1 1 1 0 Menin TRAP_alpha PF03896.16 EFC49062.1 - 2.7e-30 105.6 4.7 3.6e-30 105.2 4.7 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit ASH PF15780.5 EFC49062.1 - 0.0041 17.3 0.8 0.17 12.1 0.1 2.9 2 1 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin SRTM1 PF15872.5 EFC49062.1 - 0.039 14.1 0.2 0.067 13.3 0.2 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Elong_Iki1 PF10483.9 EFC49063.1 - 5e-11 42.6 18.1 1.9e-09 37.4 16.1 3.2 1 1 1 2 2 2 2 Elongator subunit Iki1 ABC2_membrane_3 PF12698.7 EFC49063.1 - 1.7 7.7 5.3 3.2 6.8 5.1 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein E1_DerP2_DerF2 PF02221.15 EFC49065.1 - 1.7e-15 57.6 0.1 2e-15 57.4 0.1 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 EFC49065.1 - 8.2e-10 39.2 0.2 1.1e-09 38.8 0.2 1.1 1 0 0 1 1 1 1 ML-like domain BAG PF02179.16 EFC49066.1 - 5.1e-07 30.0 2.5 5.1e-07 30.0 2.5 2.2 2 0 0 2 2 2 1 BAG domain GrpE PF01025.19 EFC49066.1 - 0.0022 17.7 9.8 0.031 13.9 0.1 2.6 1 1 0 2 2 2 2 GrpE Sec34 PF04136.15 EFC49066.1 - 0.0052 16.7 0.3 0.0052 16.7 0.3 4.1 3 1 2 5 5 5 1 Sec34-like family PHM7_cyt PF14703.6 EFC49066.1 - 0.018 15.3 2.3 0.11 12.8 1.7 2.6 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF2383 PF09537.10 EFC49066.1 - 0.019 15.3 0.1 2.9 8.3 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF2383) DUF2935 PF11155.8 EFC49066.1 - 0.048 14.0 2.6 0.12 12.7 0.3 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) Glyco_hydro_53 PF07745.13 EFC49066.1 - 0.081 11.9 0.5 4.1 6.3 0.0 2.4 2 0 0 2 2 2 0 Glycosyl hydrolase family 53 DASH_Duo1 PF08651.10 EFC49066.1 - 0.19 11.5 0.1 0.19 11.5 0.1 4.4 4 1 0 4 4 4 0 DASH complex subunit Duo1 Ntox28 PF15605.6 EFC49066.1 - 0.19 11.9 4.7 6 7.2 0.1 3.4 3 1 1 4 4 4 0 Bacterial toxin 28 DmsC PF04976.12 EFC49066.1 - 0.2 11.1 0.1 1.7 8.1 0.0 2.2 3 0 0 3 3 3 0 DMSO reductase anchor subunit (DmsC) Myb_DNA-bind_7 PF15963.5 EFC49066.1 - 0.23 11.4 2.4 0.59 10.1 0.6 2.4 2 0 0 2 2 2 0 Myb DNA-binding like SAS4 PF15460.6 EFC49066.1 - 0.26 11.4 4.6 2.7 8.1 2.0 2.9 2 1 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 DUF3829 PF12889.7 EFC49066.1 - 2.2 7.7 11.0 0.15 11.5 4.2 2.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3829) APG6_N PF17675.1 EFC49066.1 - 2.2 8.8 9.1 1.9 9.0 2.0 3.2 2 2 0 2 2 2 0 Apg6 coiled-coil region Trypsin_2 PF13365.6 EFC49067.1 - 0.046 14.6 0.0 0.31 11.9 0.0 2.3 2 1 0 2 2 2 0 Trypsin-like peptidase domain Thiolase_N PF00108.23 EFC49069.1 - 2.1e-14 53.5 2.3 1.1e-13 51.1 1.5 2.3 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFC49069.1 - 5.9e-14 51.8 0.6 2.4e-13 49.8 0.1 2.2 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFC49069.1 - 2.3e-08 33.9 3.5 1.6e-07 31.2 1.5 2.6 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 EFC49069.1 - 0.012 15.6 0.4 0.16 12.0 0.1 2.8 2 1 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain ACP_syn_III PF08545.10 EFC49069.1 - 0.016 15.0 0.3 0.11 12.4 0.4 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GAS PF13851.6 EFC49070.1 - 0.82 9.0 26.2 0.62 9.4 14.5 3.3 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding betaPIX_CC PF16523.5 EFC49070.1 - 6.4 6.7 18.9 1.2 9.1 7.7 4.0 3 2 0 3 3 3 0 betaPIX coiled coil HALZ PF02183.18 EFC49070.1 - 7.9 6.8 15.3 3.3 8.0 0.0 4.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper BLM10_N PF16547.5 EFC49071.1 - 0.014 15.6 1.1 0.023 15.0 0.9 1.5 1 1 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal CASP_C PF08172.12 EFC49072.1 - 5.7e-49 166.7 20.4 5.7e-49 166.7 20.4 4.5 1 1 3 4 4 4 1 CASP C terminal Pox_A_type_inc PF04508.12 EFC49072.1 - 1.3 9.0 16.6 18 5.4 0.7 7.0 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat HrpB7 PF09486.10 EFC49072.1 - 2.8 8.3 30.7 0.023 15.1 11.8 4.1 4 1 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) ANAPC3 PF12895.7 EFC49073.1 - 0.0042 17.3 2.0 0.12 12.7 0.1 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 RcsC PF09456.10 EFC49073.1 - 0.035 14.1 0.1 0.14 12.2 0.1 2.0 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) IBN_N PF03810.19 EFC49074.1 - 9.6e-05 22.2 0.9 0.00067 19.5 0.1 2.8 2 1 0 2 2 2 1 Importin-beta N-terminal domain SeqA PF03925.13 EFC49074.1 - 0.09 12.7 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 SeqA protein C-terminal domain MFS_1 PF07690.16 EFC49075.1 - 2.6e-15 56.2 43.6 1.1e-13 50.8 7.9 3.2 1 1 2 3 3 3 3 Major Facilitator Superfamily UNC-93 PF05978.16 EFC49075.1 - 1.7e-06 27.8 11.2 1.7e-06 27.8 11.2 4.4 3 1 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 EFC49075.1 - 8.1e-05 21.7 8.9 8.1e-05 21.7 8.9 3.1 2 2 1 3 3 3 1 Sugar (and other) transporter DUF5311 PF17238.2 EFC49076.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5311) Glyco_hydro_47 PF01532.20 EFC49077.1 - 1.1e-150 502.6 0.1 1.2e-150 502.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MIP PF00230.20 EFC49078.1 - 6e-44 150.4 14.5 3.4e-30 105.4 2.6 2.1 2 0 0 2 2 2 2 Major intrinsic protein ApoL PF05461.11 EFC49078.1 - 4.7 6.4 4.5 1.2 8.4 1.6 1.4 2 0 0 2 2 2 0 Apolipoprotein L Guanylate_cyc PF00211.20 EFC49079.1 - 9.5e-05 22.1 1.9 9.9e-05 22.0 0.3 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain FGGY_N PF00370.21 EFC49079.1 - 0.022 14.3 2.8 0.089 12.3 0.6 2.3 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, N-terminal domain Tubulin_C PF03953.17 EFC49079.1 - 0.047 13.9 0.7 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 Tubulin C-terminal domain Tetraspanin PF00335.20 EFC49079.1 - 7 6.3 9.0 0.91 9.2 0.5 2.4 2 0 0 2 2 2 0 Tetraspanin family Kdo PF06293.14 EFC49080.1 - 2.4e-05 23.8 0.1 0.00029 20.2 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC49080.1 - 6.3e-05 23.0 0.1 0.00013 22.0 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 EFC49080.1 - 0.0044 16.6 0.1 0.013 15.1 0.1 1.8 1 0 0 1 1 1 1 RIO1 family DSPc PF00782.20 EFC49080.1 - 0.0053 16.6 0.5 0.21 11.4 0.0 3.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 EFC49080.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Pkinase_Tyr PF07714.17 EFC49080.1 - 0.091 12.0 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase UCH PF00443.29 EFC49081.1 - 8.7e-51 172.9 2.4 8.7e-51 172.9 2.4 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC49081.1 - 1.8e-16 60.7 3.9 1.8e-16 60.7 3.9 3.7 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase Glu-tRNAGln PF02686.15 EFC49082.1 - 6.4e-06 26.4 0.0 1.1e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Pkinase_Tyr PF07714.17 EFC49083.1 - 4.1e-46 157.4 0.0 8.6e-44 149.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC49083.1 - 2.5e-45 154.9 0.0 4.5e-45 154.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain IF4E PF01652.18 EFC49083.1 - 4.9e-28 97.9 2.4 9.1e-28 97.1 2.4 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Haspin_kinase PF12330.8 EFC49083.1 - 0.00074 18.6 3.3 0.0016 17.4 0.0 2.8 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 EFC49083.1 - 0.029 13.7 0.0 0.11 11.8 0.0 2.0 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC49083.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC49083.1 - 0.13 11.0 0.0 0.13 11.0 0.0 2.2 2 1 0 2 2 2 0 Fungal protein kinase SGL PF08450.12 EFC49083.1 - 0.17 11.5 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region CENP-H PF05837.12 EFC49084.1 - 0.0027 18.1 12.1 0.0027 18.1 12.1 5.8 3 2 1 5 5 5 2 Centromere protein H (CENP-H) LPP PF04728.13 EFC49084.1 - 0.046 14.1 0.5 0.046 14.1 0.5 7.6 7 1 0 8 8 8 0 Lipoprotein leucine-zipper Terminase_6C PF17289.2 EFC49084.1 - 4.4 7.4 9.2 1.5 8.9 2.2 2.9 2 1 0 2 2 2 0 Terminase RNaseH-like domain Piwi PF02171.17 EFC49085.1 - 3.9e-69 233.2 3.5 4.5e-69 233.0 3.5 1.0 1 0 0 1 1 1 1 Piwi domain vWA-TerF-like PF10138.9 EFC49085.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 vWA found in TerF C terminus PAZ PF02170.22 EFC49086.1 - 1.5e-24 86.4 1.9 1.9e-24 86.0 1.9 1.1 1 0 0 1 1 1 1 PAZ domain GTP_EFTU PF00009.27 EFC49087.1 - 1.5e-24 86.6 0.0 3.2e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 EFC49087.1 - 2.6e-07 30.9 2.3 8.1e-07 29.3 0.5 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 EFC49087.1 - 2.3e-06 27.9 0.1 1.2e-05 25.6 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 EFC49087.1 - 0.00073 19.6 0.0 0.0019 18.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 EFC49087.1 - 0.042 13.1 0.1 0.11 11.8 0.1 1.7 1 0 0 1 1 1 0 Septin Ephrin_rec_like PF07699.13 EFC49088.1 - 4e-08 32.9 15.5 3e-06 26.9 4.8 4.6 3 1 1 4 4 4 3 Putative ephrin-receptor like TIG PF01833.24 EFC49088.1 - 1.3e-06 28.4 0.0 1.3e-06 28.4 0.0 6.7 6 1 0 6 6 6 1 IPT/TIG domain TRP PF06011.12 EFC49088.1 - 1.3 7.7 38.7 0.0044 15.8 14.3 3.3 2 1 1 3 3 3 0 Transient receptor potential (TRP) ion channel PPR PF01535.20 EFC49089.1 - 1.5e-19 68.8 8.5 0.18 12.1 0.0 8.6 9 0 0 9 9 9 6 PPR repeat PPR_2 PF13041.6 EFC49089.1 - 9.9e-16 57.7 12.6 1.8e-07 31.2 0.1 7.5 6 2 3 9 9 9 4 PPR repeat family PPR_3 PF13812.6 EFC49089.1 - 1.7e-13 50.4 4.8 3.5e-08 33.4 0.0 6.3 6 0 0 6 6 6 1 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC49089.1 - 3.3e-09 36.4 0.0 9e-05 21.9 0.0 2.8 1 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFC49089.1 - 4.1e-06 26.4 0.0 1 9.1 0.0 5.2 6 0 0 6 6 6 2 PPR repeat Clathrin PF00637.20 EFC49089.1 - 0.0087 15.9 11.4 0.059 13.2 0.7 4.8 3 2 2 5 5 5 1 Region in Clathrin and VPS Vps39_1 PF10366.9 EFC49089.1 - 0.04 14.2 0.1 0.62 10.4 0.0 3.0 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 1 SMK-1 PF04802.15 EFC49089.1 - 0.042 13.7 2.1 0.14 12.0 0.8 2.3 2 0 0 2 2 2 0 Component of IIS longevity pathway SMK-1 MNE1 PF13762.6 EFC49089.1 - 4.8 7.2 15.7 10 6.1 8.4 3.7 3 1 0 3 3 3 0 Mitochondrial splicing apparatus component FAD_binding_3 PF01494.19 EFC49092.1 - 4.8e-07 29.4 0.0 7e-05 22.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain DUF1279 PF06916.13 EFC49093.1 - 2.1e-16 60.2 0.2 4.5e-16 59.2 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Biotin_lipoyl PF00364.22 EFC49093.1 - 0.018 14.9 0.3 0.062 13.2 0.3 1.9 1 1 0 1 1 1 0 Biotin-requiring enzyme Complex1_LYR PF05347.15 EFC49094.1 - 2e-10 40.5 1.5 2.6e-10 40.2 1.5 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFC49094.1 - 0.0072 17.0 0.2 0.0081 16.9 0.2 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Guanylate_cyc_2 PF09778.9 EFC49094.1 - 0.087 12.2 0.3 0.1 12.0 0.3 1.0 1 0 0 1 1 1 0 Guanylylate cyclase Pro_isomerase PF00160.21 EFC49095.1 - 1.4e-41 142.4 0.1 1.5e-41 142.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Copine PF07002.16 EFC49096.1 - 6e-63 212.2 0.0 8.3e-63 211.7 0.0 1.2 1 0 0 1 1 1 1 Copine vWA-TerF-like PF10138.9 EFC49096.1 - 6.2e-12 46.0 0.0 1.2e-11 45.1 0.0 1.5 1 1 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 EFC49096.1 - 0.00095 19.5 0.0 0.0019 18.5 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC49096.1 - 0.11 12.4 0.0 0.33 10.9 0.0 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain ABC_tran PF00005.27 EFC49097.1 - 4.5e-28 98.5 0.1 6.2e-28 98.0 0.1 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC49097.1 - 0.00014 21.4 1.4 0.00099 18.6 1.4 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 EFC49097.1 - 0.00035 20.5 0.3 0.0011 18.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 EFC49097.1 - 0.004 17.4 0.1 0.1 12.8 0.1 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit PRA1 PF03208.19 EFC49098.1 - 0.074 12.7 0.6 0.074 12.7 0.6 2.5 3 0 0 3 3 3 0 PRA1 family protein DRMBL PF07522.14 EFC49099.1 - 6.4e-20 71.4 0.5 1.3e-19 70.4 0.5 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 EFC49099.1 - 0.00018 21.1 0.0 0.00037 20.1 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFC49099.1 - 0.00033 20.7 1.4 0.2 11.6 1.2 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily SARAF PF06682.12 EFC49100.1 - 0.0071 16.0 1.9 0.0071 16.0 1.9 2.1 2 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis DUF4834 PF16118.5 EFC49100.1 - 2.7 9.0 0.0 2.7 9.0 0.0 4.9 4 1 1 5 5 5 0 Domain of unknown function (DUF4834) Methyltransf_11 PF08241.12 EFC49101.1 - 0.027 15.1 0.0 0.059 14.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Stig1 PF04885.13 EFC49101.1 - 0.26 11.7 11.2 0.45 11.0 11.2 1.3 1 0 0 1 1 1 0 Stigma-specific protein, Stig1 RhoGAP PF00620.27 EFC49102.1 - 8.9e-38 129.5 0.2 6.2e-30 104.0 0.5 2.3 2 0 0 2 2 2 2 RhoGAP domain F-box PF00646.33 EFC49102.1 - 0.0096 15.8 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 F-box domain Pkinase PF00069.25 EFC49104.1 - 2.5e-10 40.2 8.6 9.2e-08 31.8 0.8 4.2 4 0 0 4 4 4 3 Protein kinase domain Ras PF00071.22 EFC49104.1 - 9.1e-09 35.1 2.4 1e-07 31.7 0.1 3.0 3 0 0 3 3 3 1 Ras family Pkinase_Tyr PF07714.17 EFC49104.1 - 4.3e-06 26.2 1.1 2.3e-05 23.8 0.3 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase MTHFR PF02219.17 EFC49105.1 - 1.6e-113 378.8 0.0 2.2e-113 378.3 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Radical_SAM PF04055.21 EFC49105.1 - 0.0021 18.4 0.0 0.099 13.0 0.0 2.5 1 1 0 1 1 1 1 Radical SAM superfamily DUF747 PF05346.11 EFC49106.1 - 2.8e-85 286.6 20.9 4.6e-85 285.9 20.9 1.3 1 0 0 1 1 1 1 Eukaryotic membrane protein family PPR_2 PF13041.6 EFC49107.1 - 7.1e-13 48.5 4.8 0.00056 20.1 0.1 4.7 4 0 0 4 4 4 3 PPR repeat family PPR_1 PF12854.7 EFC49107.1 - 1.9e-06 27.4 0.0 0.00031 20.4 0.0 3.2 3 0 0 3 3 3 1 PPR repeat PPR PF01535.20 EFC49107.1 - 3.8e-06 26.8 0.9 0.00027 21.0 0.1 3.8 3 0 0 3 3 3 1 PPR repeat PPR_3 PF13812.6 EFC49107.1 - 2.8e-05 24.1 3.9 0.35 11.0 0.0 4.8 5 0 0 5 5 5 2 Pentatricopeptide repeat domain ATP13 PF12921.7 EFC49107.1 - 0.00012 21.9 1.2 0.4 10.5 0.1 3.0 2 0 0 2 2 2 2 Mitochondrial ATPase expression TPR_14 PF13428.6 EFC49107.1 - 0.027 15.3 0.1 34 5.6 0.0 3.2 4 0 0 4 4 3 0 Tetratricopeptide repeat RPN7 PF10602.9 EFC49107.1 - 0.04 13.6 0.3 0.34 10.6 0.1 2.6 3 0 0 3 3 3 0 26S proteasome subunit RPN7 TPR_7 PF13176.6 EFC49107.1 - 0.05 13.6 0.1 3 8.1 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49107.1 - 0.056 13.3 0.1 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49107.1 - 0.073 13.3 0.2 3.5 8.1 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49107.1 - 0.12 12.5 0.4 4.4 7.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Hexapep PF00132.24 EFC49108.1 - 5.3e-10 38.6 17.7 0.0002 21.0 1.2 4.6 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 EFC49108.1 - 2e-08 34.1 0.0 4.1e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 EFC49108.1 - 0.00022 20.9 16.3 0.00038 20.2 6.3 3.0 2 1 0 2 2 2 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 EFC49108.1 - 0.00032 19.0 2.7 0.00055 18.2 1.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 EFC49108.1 - 0.0012 19.2 0.0 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Connexin PF00029.19 EFC49108.1 - 0.42 10.3 1.9 0.81 9.4 1.9 1.5 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 EFC49108.1 - 0.58 8.0 4.0 0.84 7.5 4.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RRN3 PF05327.11 EFC49108.1 - 2.6 6.5 16.3 4.1 5.8 16.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CPSF100_C PF13299.6 EFC49108.1 - 3.6 7.8 9.0 8.7 6.5 9.0 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 EFC49108.1 - 4.4 5.5 24.9 5.3 5.2 23.5 1.7 2 0 0 2 2 2 0 CDC45-like protein DUF913 PF06025.12 EFC49108.1 - 6.4 5.6 7.2 10 5.0 7.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ORC_WH_C PF18137.1 EFC49108.1 - 7.9 6.6 12.6 17 5.4 12.6 1.6 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Syntaxin-6_N PF09177.11 EFC49109.1 - 0.41 11.2 3.5 0.37 11.4 0.1 2.6 2 0 0 2 2 2 0 Syntaxin 6, N-terminal HEPN_Apea PF18739.1 EFC49109.1 - 0.56 10.7 5.2 0.33 11.4 1.0 2.7 1 1 1 2 2 2 0 Apea-like HEPN Arm PF00514.23 EFC49110.1 - 3.8e-29 99.8 19.9 3.4e-06 26.9 0.0 9.1 10 0 0 10 10 10 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFC49110.1 - 1.2e-18 67.3 4.2 5e-07 30.0 0.4 5.2 2 2 5 7 7 7 6 HEAT repeats HEAT PF02985.22 EFC49110.1 - 1.4e-18 65.3 5.8 0.0012 18.9 0.0 7.4 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 EFC49110.1 - 2.3e-16 60.3 0.3 0.00032 20.8 0.0 3.9 2 2 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 EFC49110.1 - 3e-15 56.3 15.6 0.00077 19.9 0.8 7.0 4 2 3 7 7 7 5 HEAT-like repeat Adaptin_N PF01602.20 EFC49110.1 - 8.1e-11 41.2 5.7 0.009 14.6 0.8 4.0 2 1 2 4 4 4 4 Adaptin N terminal region CHASE6_C PF17150.4 EFC49110.1 - 4.3e-07 30.5 1.4 0.066 13.9 0.1 5.9 5 2 2 7 7 7 1 C-terminal domain of two-partite extracellular sensor domain HEAT_PBS PF03130.16 EFC49110.1 - 9.4e-06 25.8 4.8 0.18 12.5 0.1 6.1 6 1 0 6 6 6 1 PBS lyase HEAT-like repeat RICTOR_N PF14664.6 EFC49110.1 - 2e-05 23.8 1.1 0.0006 18.9 0.5 2.8 1 1 1 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term Atx10homo_assoc PF09759.9 EFC49110.1 - 2e-05 24.6 4.3 5 7.2 0.1 6.0 2 2 5 7 7 7 2 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 EFC49110.1 - 0.00011 22.3 1.5 1.3 9.2 0.0 4.2 4 0 0 4 4 4 1 V-ATPase subunit H CLASP_N PF12348.8 EFC49110.1 - 0.00018 21.1 0.1 0.22 11.1 0.0 3.2 4 0 0 4 4 4 2 CLASP N terminal DUF3361 PF11841.8 EFC49110.1 - 0.051 13.5 2.9 13 5.7 0.1 4.4 3 3 1 4 4 4 0 Domain of unknown function (DUF3361) DUF3731 PF12531.8 EFC49110.1 - 0.1 12.4 0.1 0.57 10.0 0.0 2.2 2 0 0 2 2 2 0 DNA-K related protein HEAT_UF PF18817.1 EFC49110.1 - 0.26 11.6 4.2 0.91 9.8 0.0 3.8 5 0 0 5 5 5 0 Repeat of uncharacterized protein PH0542 XPC-binding PF09280.11 EFC49110.1 - 0.38 10.5 5.5 34 4.3 0.0 5.1 6 0 0 6 6 6 0 XPC-binding domain zf-primase PF09329.11 EFC49111.1 - 4.9e-05 23.1 2.2 0.00026 20.7 1.5 2.5 2 0 0 2 2 2 1 Primase zinc finger Phospholamban PF04272.14 EFC49112.1 - 0.056 12.9 0.9 0.17 11.4 0.9 1.8 1 0 0 1 1 1 0 Phospholamban SP_C-Propep PF08999.10 EFC49112.1 - 0.15 11.9 4.5 3.8 7.3 1.6 2.4 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide LRRC37AB_C PF14914.6 EFC49112.1 - 5.8 6.8 8.3 51 3.8 4.3 2.7 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Ras PF00071.22 EFC49113.1 - 2e-06 27.5 0.0 2.8e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Kelch_3 PF13415.6 EFC49114.1 - 6.3e-26 90.1 0.4 5.4e-07 29.7 0.0 5.7 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_4 PF13418.6 EFC49114.1 - 1.7e-22 79.2 4.0 1.8e-06 27.9 0.0 5.8 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC49114.1 - 8.4e-22 76.7 5.5 1.9e-08 34.3 0.0 5.3 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 EFC49114.1 - 8.6e-22 76.7 7.3 5.1e-05 23.2 0.2 5.3 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFC49114.1 - 2.9e-15 55.5 7.2 7.6e-06 25.4 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 EFC49114.1 - 9e-13 47.6 7.4 9.3e-06 25.4 0.0 4.9 5 0 0 5 5 5 3 Kelch motif CTD_bind PF04818.13 EFC49115.1 - 1.3e-06 29.1 0.3 3.7e-06 27.7 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase II-binding domain. VHS PF00790.19 EFC49115.1 - 0.00056 19.8 0.0 0.00067 19.5 0.0 1.3 1 1 0 1 1 1 1 VHS domain Guanylate_kin PF00625.21 EFC49116.1 - 7.4e-62 208.3 0.0 8.4e-62 208.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_33 PF13671.6 EFC49116.1 - 1.1e-05 25.7 0.0 4.4e-05 23.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC49116.1 - 6.1e-05 23.6 0.2 0.00015 22.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 EFC49116.1 - 0.00074 19.5 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 EFC49116.1 - 0.0012 19.1 0.1 0.0031 17.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 EFC49116.1 - 0.0036 17.8 1.4 0.036 14.6 1.4 2.1 1 1 0 1 1 1 1 ABC transporter AAA_17 PF13207.6 EFC49116.1 - 0.0038 17.7 0.8 0.12 12.8 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC49116.1 - 0.0082 16.5 0.0 0.014 15.8 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 EFC49116.1 - 0.0094 15.9 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 EFC49116.1 - 0.011 15.8 0.3 0.035 14.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFC49116.1 - 0.011 15.8 0.1 0.032 14.3 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase NTPase_1 PF03266.15 EFC49116.1 - 0.031 14.2 0.1 0.045 13.7 0.1 1.5 1 1 0 1 1 1 0 NTPase RNA_helicase PF00910.22 EFC49116.1 - 0.032 14.6 0.0 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 RNA helicase Septin PF00735.18 EFC49116.1 - 0.038 13.3 1.0 0.092 12.0 0.1 2.2 1 1 1 2 2 2 0 Septin AAA_7 PF12775.7 EFC49116.1 - 0.038 13.5 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 EFC49116.1 - 0.074 12.2 0.1 0.24 10.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain AAA PF00004.29 EFC49116.1 - 0.12 12.8 0.3 0.29 11.5 0.3 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFC49116.1 - 0.13 12.1 0.0 0.3 11.0 0.0 1.6 2 0 0 2 2 2 0 NACHT domain EF-hand_1 PF00036.32 EFC49117.1 - 1.7e-10 39.6 0.2 7e-07 28.4 0.1 2.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 EFC49117.1 - 9e-10 37.7 0.2 1.1e-07 31.2 0.1 2.4 2 1 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EFC49117.1 - 7.8e-08 32.7 0.1 8.9e-06 26.1 0.1 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 EFC49117.1 - 5.2e-06 25.7 0.1 9.9e-05 21.7 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 EFC49117.1 - 8.6e-06 25.5 0.2 0.00011 22.0 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain pair Post_transc_reg PF13797.6 EFC49117.1 - 0.0094 15.8 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 1 Post-transcriptional regulator BRCT_2 PF16589.5 EFC49118.1 - 5.3e-50 167.8 13.9 2.3e-15 56.8 0.8 6.2 6 0 0 6 6 6 6 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFC49118.1 - 6.3e-35 119.4 16.8 1e-11 45.1 0.2 6.4 6 0 0 6 6 6 6 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 EFC49118.1 - 2e-20 72.5 0.3 3.2e-11 43.0 0.0 5.3 5 0 0 5 5 5 3 twin BRCT domain RTT107_BRCT_5 PF16770.5 EFC49118.1 - 1e-14 54.2 6.1 5.5e-10 39.0 0.1 5.6 5 0 0 5 5 5 2 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EFC49118.1 - 6.8e-13 48.7 2.0 0.00043 20.5 0.0 5.0 5 0 0 5 5 5 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EFC49118.1 - 0.00062 19.8 0.0 1.5 8.9 0.0 3.6 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain SWIRM-assoc_2 PF16496.5 EFC49118.1 - 0.21 10.4 0.0 0.21 10.4 0.0 2.5 2 1 0 2 2 2 0 SWIRM-associated domain at the N-terminal HMG_box PF00505.19 EFC49119.1 - 5.3e-39 132.5 15.0 3.9e-23 81.6 4.1 3.1 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC49119.1 - 8.3e-23 80.8 18.0 6.7e-12 45.8 3.6 2.9 2 1 0 2 2 2 2 HMG-box domain MlaC PF05494.12 EFC49119.1 - 0.00011 22.0 4.6 0.012 15.4 0.1 2.2 1 1 1 2 2 2 2 MlaC protein DUF1289 PF06945.13 EFC49119.1 - 0.22 11.3 0.8 4.7 7.1 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) Cpn60_TCP1 PF00118.24 EFC49120.1 - 8.8e-76 255.5 5.6 2e-75 254.3 5.6 1.6 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family CAF1 PF04857.20 EFC49121.1 - 6.9e-66 222.6 8.1 6.9e-66 222.6 8.1 1.9 3 0 0 3 3 3 1 CAF1 family ribonuclease RRM_1 PF00076.22 EFC49121.1 - 0.00014 21.6 0.0 0.0066 16.3 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 EFC49121.1 - 0.0027 17.7 0.2 0.0027 17.7 0.2 3.1 4 1 0 4 4 4 1 RNA binding domain LRR_4 PF12799.7 EFC49122.1 - 0.0073 16.7 1.6 0.0073 16.7 1.6 4.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC49122.1 - 0.0075 16.2 7.1 15 5.9 0.1 5.4 5 0 0 5 5 5 1 Leucine Rich repeat LRR_8 PF13855.6 EFC49122.1 - 0.031 14.0 5.3 0.76 9.6 4.9 3.2 1 1 1 2 2 2 0 Leucine rich repeat LRR_6 PF13516.6 EFC49123.1 - 6.5e-34 113.1 40.5 0.0002 21.1 0.6 15.9 15 0 0 15 15 15 10 Leucine Rich repeat LRR_1 PF00560.33 EFC49123.1 - 1.7e-05 24.7 22.6 30 5.7 0.0 12.5 15 0 0 15 15 15 1 Leucine Rich Repeat LRR_4 PF12799.7 EFC49123.1 - 1.9e-05 24.9 46.1 0.0022 18.4 0.1 10.1 7 1 4 11 11 11 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49123.1 - 0.96 9.3 33.7 0.13 12.1 0.3 7.9 6 2 2 8 8 8 0 Leucine rich repeat Glyco_transf_18 PF15024.6 EFC49124.1 - 1.5e-08 33.7 10.9 2.2e-08 33.2 10.9 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 ELFV_dehydrog PF00208.21 EFC49125.1 - 5.8e-58 196.5 1.1 5.5e-56 190.0 0.3 2.2 1 1 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 EFC49125.1 - 6.9e-50 168.3 0.0 1.2e-49 167.5 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain DUF4817 PF16087.5 EFC49125.1 - 0.00053 19.7 0.2 0.002 17.9 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain (DUF4817) AdoHcyase_NAD PF00670.21 EFC49125.1 - 0.029 14.5 0.3 0.058 13.5 0.3 1.6 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Bac_GDH PF05088.12 EFC49125.1 - 0.04 11.4 0.0 0.087 10.3 0.0 1.5 2 0 0 2 2 2 0 Bacterial NAD-glutamate dehydrogenase 2-Hacid_dh_C PF02826.19 EFC49125.1 - 0.059 12.7 0.1 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DNA_pol_A PF00476.20 EFC49126.1 - 4.4e-85 286.0 1.9 4.4e-85 286.0 1.9 1.6 2 0 0 2 2 2 1 DNA polymerase family A DEAD PF00270.29 EFC49126.1 - 8.7e-18 64.7 0.0 2.1e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC49126.1 - 5.1e-11 42.9 2.2 3.4e-10 40.2 0.1 3.4 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DUF4332 PF14229.6 EFC49126.1 - 0.0065 16.7 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) HHH_5 PF14520.6 EFC49126.1 - 0.0099 16.5 0.0 0.05 14.2 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain LRR_4 PF12799.7 EFC49127.1 - 0.052 14.0 10.4 1.5 9.3 0.7 5.0 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49127.1 - 0.4 10.5 3.0 1 9.2 0.7 2.9 4 0 0 4 4 4 0 Leucine rich repeat LBP_BPI_CETP_C PF02886.17 EFC49128.1 - 1e-18 67.7 0.4 2.7e-18 66.3 0.4 1.7 1 0 0 1 1 1 1 LBP / BPI / CETP family, C-terminal domain LBP_BPI_CETP PF01273.25 EFC49128.1 - 5.2e-15 55.4 4.7 5.2e-15 55.4 4.7 2.0 2 0 0 2 2 2 1 LBP / BPI / CETP family, N-terminal domain DUF383 PF04063.14 EFC49129.1 - 0.00045 19.9 4.5 0.12 12.1 0.4 3.3 3 1 0 3 3 3 2 Domain of unknown function (DUF383) NTF-like PF14540.6 EFC49129.1 - 0.002 17.9 0.4 0.0078 16.0 0.4 2.0 1 0 0 1 1 1 1 Nucleotidyltransferase-like DUF3361 PF11841.8 EFC49129.1 - 0.002 18.1 9.9 0.0042 17.0 0.9 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF3361) DUF2481 PF10654.9 EFC49129.1 - 0.0032 17.5 1.3 0.79 9.7 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF2481) YEATS PF03366.16 EFC49131.1 - 1.2e-22 79.6 0.5 2.2e-22 78.8 0.5 1.4 1 0 0 1 1 1 1 YEATS family zf-C3HC4_3 PF13920.6 EFC49131.1 - 1.3e-08 34.5 6.3 2.1e-08 33.9 6.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 EFC49131.1 - 2.6e-08 33.9 12.5 2.6e-08 33.9 12.5 1.6 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 EFC49131.1 - 1e-07 31.7 11.1 1.6e-07 31.0 11.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC49131.1 - 1.1e-06 28.5 8.3 4e-06 26.7 8.6 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFC49131.1 - 1.4e-06 28.5 10.5 2.3e-06 27.8 10.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFC49131.1 - 2.8e-06 27.1 10.6 4.8e-06 26.3 10.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 EFC49131.1 - 0.00069 19.6 1.1 0.0015 18.5 1.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 EFC49131.1 - 0.0044 17.0 11.8 0.016 15.1 12.2 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-Nse PF11789.8 EFC49131.1 - 0.0046 16.7 5.4 0.012 15.4 5.4 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 EFC49131.1 - 0.0067 16.2 9.9 0.035 13.9 10.3 1.9 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 EFC49131.1 - 0.024 14.7 4.3 0.042 14.0 4.3 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 Rad50_zn_hook PF04423.14 EFC49131.1 - 0.12 12.2 1.6 0.56 10.1 0.1 2.3 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-RING_6 PF14835.6 EFC49131.1 - 0.28 11.1 7.2 0.56 10.1 7.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 EFC49131.1 - 0.32 11.3 12.2 1.7 9.0 12.3 2.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 EFC49131.1 - 0.49 10.3 13.3 3.5 7.5 12.3 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Ins145_P3_rec PF08709.11 EFC49132.1 - 1e-27 96.8 2.2 4.4e-24 84.9 1.8 3.7 2 1 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor RIH_assoc PF08454.11 EFC49132.1 - 2.7e-23 81.7 1.8 2.7e-23 81.7 1.8 7.4 9 0 0 9 9 9 1 RyR and IP3R Homology associated MIR PF02815.19 EFC49132.1 - 1.1e-17 64.5 0.3 2.9e-15 56.6 0.0 2.9 2 1 0 2 2 2 2 MIR domain RYDR_ITPR PF01365.21 EFC49132.1 - 4.5e-11 42.6 25.0 5.6e-08 32.4 0.8 4.7 5 0 0 5 5 5 2 RIH domain U1snRNP70_N PF12220.8 EFC49132.1 - 0.025 15.2 4.7 0.03 15.0 0.5 2.8 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Folliculin PF11704.8 EFC49133.1 - 2.8e-38 131.7 2.0 2.4e-37 128.6 0.0 2.3 2 0 0 2 2 2 1 Vesicle coat protein involved in Golgi to plasma membrane transport Folliculin_C PF16692.5 EFC49133.1 - 3.1e-20 72.9 1.0 3.1e-20 72.9 1.0 2.2 2 1 0 3 3 3 1 Folliculin C-terminal domain DUF1329 PF07044.11 EFC49134.1 - 0.0096 15.2 0.6 0.0099 15.2 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1329) DUF2464 PF10240.9 EFC49134.1 - 0.23 11.0 6.9 0.3 10.6 6.9 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 WD40 PF00400.32 EFC49135.1 - 5.7e-60 197.9 16.1 2.5e-10 40.8 0.6 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49135.1 - 2.9e-24 85.2 0.0 0.00031 21.0 0.0 6.3 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 EFC49135.1 - 8.8e-19 67.6 7.8 1.4e-18 66.9 7.8 1.3 1 0 0 1 1 1 1 Tup N-terminal Ge1_WD40 PF16529.5 EFC49135.1 - 1.9e-09 37.0 0.3 0.23 10.4 0.0 5.6 3 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC49135.1 - 1.3e-07 31.3 0.0 0.52 9.6 0.0 4.8 4 2 2 6 6 6 2 WD40-like domain Nup160 PF11715.8 EFC49135.1 - 2.9e-06 26.2 0.0 0.35 9.5 0.0 4.0 1 1 3 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 EFC49135.1 - 4.7e-06 26.6 0.0 0.17 11.8 0.0 3.8 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 EFC49135.1 - 9.6e-06 25.1 0.2 0.021 14.2 0.0 3.3 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 EFC49135.1 - 2.5e-05 24.1 5.0 1.8 8.6 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 EFC49135.1 - 8.5e-05 21.2 0.1 0.003 16.1 0.0 2.4 1 1 2 3 3 3 1 Cytochrome D1 heme domain Frtz PF11768.8 EFC49135.1 - 0.0027 16.1 0.0 0.16 10.2 0.0 2.9 3 1 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Nup88 PF10168.9 EFC49135.1 - 0.064 11.1 3.4 0.093 10.5 3.4 1.1 1 0 0 1 1 1 0 Nuclear pore component DUF5122 PF17164.4 EFC49135.1 - 0.12 12.7 0.4 41 4.6 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller Uso1_p115_C PF04871.13 EFC49135.1 - 0.15 12.4 4.4 0.31 11.4 4.4 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region TACC_C PF05010.14 EFC49135.1 - 0.2 11.4 4.8 0.29 10.9 4.8 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Filament PF00038.21 EFC49135.1 - 0.33 10.5 7.1 0.45 10.1 7.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein SHE3 PF17078.5 EFC49135.1 - 0.34 10.6 5.6 0.53 10.0 5.6 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF724 PF05266.14 EFC49135.1 - 0.39 10.5 4.4 0.64 9.8 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FapA PF03961.13 EFC49135.1 - 0.54 8.8 2.8 0.8 8.2 2.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlxA PF14282.6 EFC49135.1 - 1.1 9.3 7.9 2.6 8.1 7.9 1.6 1 0 0 1 1 1 0 FlxA-like protein OmpH PF03938.14 EFC49135.1 - 4.1 7.8 7.7 6.9 7.0 7.7 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HMMR_N PF15905.5 EFC49135.1 - 4.4 6.7 8.5 6.5 6.1 8.5 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal THOC7 PF05615.13 EFC49135.1 - 4.5 7.5 7.8 9.3 6.5 7.8 1.5 1 1 0 1 1 1 0 Tho complex subunit 7 CSD PF00313.22 EFC49136.1 - 0.034 14.0 0.5 0.68 9.8 0.0 2.9 3 0 0 3 3 3 0 'Cold-shock' DNA-binding domain Prok-RING_1 PF14446.6 EFC49136.1 - 0.07 13.1 2.1 0.15 12.0 2.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING-like PF08746.11 EFC49136.1 - 2.5 8.5 6.6 5.4 7.4 6.6 1.5 1 0 0 1 1 1 0 RING-like domain NDUF_B4 PF07225.12 EFC49136.1 - 4.8 7.1 7.3 6.5 6.7 5.0 2.2 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) FANCL_C PF11793.8 EFC49136.1 - 8.5 6.6 8.6 45 4.3 8.7 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain DUF3760 PF12586.8 EFC49137.1 - 0.085 13.0 0.3 0.25 11.5 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) AAA_22 PF13401.6 EFC49139.1 - 0.04 14.2 0.0 0.24 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFC49139.1 - 0.055 13.6 0.1 1.2 9.3 0.0 3.1 4 0 0 4 4 4 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC49139.1 - 0.055 13.2 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 EFC49139.1 - 0.057 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 EFC49139.1 - 0.081 13.4 0.1 0.081 13.4 0.1 3.1 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 EFC49139.1 - 0.11 12.9 0.0 0.27 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Tweety PF04906.13 EFC49140.1 - 0.78 8.3 8.5 0.25 10.0 0.1 3.2 3 0 0 3 3 3 0 Tweety TFIID_NTD2 PF04494.15 EFC49140.1 - 8.2 6.7 8.4 0.58 10.4 0.5 3.1 4 1 0 4 4 4 0 WD40 associated region in TFIID subunit, NTD2 domain Trypan_PARP PF05887.11 EFC49141.1 - 9.4e-06 25.6 98.5 0.033 14.2 36.5 3.0 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) Trypan_PARP PF05887.11 EFC49142.1 - 3.4e-06 27.1 115.5 0.077 13.0 37.1 3.1 1 1 2 3 3 3 3 Procyclic acidic repetitive protein (PARP) Guanylate_cyc PF00211.20 EFC49143.1 - 4.3e-19 68.8 0.0 6.2e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF2076 PF09849.9 EFC49145.1 - 0.056 13.5 10.7 0.073 13.1 10.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Pex14_N PF04695.13 EFC49145.1 - 0.14 12.9 12.9 0.17 12.5 12.9 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SARAF PF06682.12 EFC49145.1 - 0.29 10.7 9.8 0.1 12.2 7.2 1.5 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3545 PF12065.8 EFC49146.1 - 2.4 8.3 6.5 5.2 7.2 6.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3545) Pkinase PF00069.25 EFC49148.1 - 1.2e-13 51.1 0.1 3.5e-13 49.5 0.1 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49148.1 - 6e-05 22.4 0.0 0.00022 20.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Glyco_hydro_11 PF00457.17 EFC49148.1 - 0.051 13.2 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolases family 11 APH PF01636.23 EFC49148.1 - 0.09 12.7 0.2 0.15 11.9 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1694 PF07997.11 EFC49149.1 - 0.058 13.5 0.3 0.12 12.4 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) IFRD PF05004.13 EFC49150.1 - 2.2e-31 109.1 15.7 2.2e-30 105.8 15.7 2.0 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) FSIP1 PF15554.6 EFC49152.1 - 0.026 13.6 5.7 0.033 13.3 5.7 1.1 1 0 0 1 1 1 0 FSIP1 family PhyH PF05721.13 EFC49153.1 - 5.2e-06 26.9 0.0 9.7e-05 22.7 0.0 2.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Gln-synt_C PF00120.24 EFC49154.1 - 2.4e-18 66.3 0.0 7.6e-17 61.3 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 EFC49154.1 - 5.7e-10 38.8 0.0 1.1e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain BLUF PF04940.12 EFC49155.1 - 4.5e-24 84.4 2.8 2.1e-23 82.2 0.0 3.5 4 0 0 4 4 4 1 Sensors of blue-light using FAD BTB_2 PF02214.22 EFC49155.1 - 4.6e-21 75.0 4.2 7.7e-11 42.2 0.2 3.3 2 0 0 2 2 2 2 BTB/POZ domain Sec8_exocyst PF04048.14 EFC49155.1 - 0.0027 17.6 3.7 0.26 11.2 1.0 3.0 2 0 0 2 2 2 2 Sec8 exocyst complex component specific domain RGS PF00615.19 EFC49155.1 - 5.3 7.3 11.5 0.1 12.8 1.6 3.3 3 0 0 3 3 3 0 Regulator of G protein signaling domain TPR_12 PF13424.6 EFC49156.1 - 5.7e-56 186.7 7.9 1.4e-10 41.3 0.0 9.6 7 2 2 9 9 9 7 Tetratricopeptide repeat TPR_10 PF13374.6 EFC49156.1 - 6.1e-28 95.9 12.4 3.1e-06 26.9 0.4 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49156.1 - 3.4e-24 82.9 30.5 0.0019 18.2 0.2 12.1 13 0 0 13 13 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49156.1 - 1.7e-17 62.4 40.6 0.0014 18.3 0.3 11.9 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_7 PF13176.6 EFC49156.1 - 2.2e-15 55.5 24.6 4.8e-05 23.1 0.2 10.4 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49156.1 - 1e-11 44.1 39.0 0.15 12.4 0.2 12.3 12 0 0 12 12 12 5 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC49156.1 - 6.4e-09 35.6 3.9 0.00023 20.7 1.5 5.0 4 1 1 5 5 5 1 MalT-like TPR region TPR_14 PF13428.6 EFC49156.1 - 1.1e-07 32.0 4.8 96 4.2 0.0 10.1 12 0 0 12 12 9 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49156.1 - 2.7e-05 24.6 14.4 0.012 16.1 0.3 7.2 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49156.1 - 0.00026 21.6 13.1 1.1 10.0 0.0 7.1 9 1 0 9 9 5 2 Tetratricopeptide repeat DUF5113 PF17140.4 EFC49156.1 - 0.0031 17.3 1.7 2 8.2 0.0 3.9 2 1 1 3 3 3 1 Domain of unknown function (DUF5113) MIT PF04212.18 EFC49156.1 - 0.0035 17.4 0.2 0.0035 17.4 0.2 6.9 8 1 1 9 9 7 2 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 EFC49156.1 - 0.0049 16.6 15.5 0.011 15.5 0.0 3.2 3 1 0 3 3 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 EFC49156.1 - 0.0074 16.9 21.1 0.37 11.5 0.1 8.8 10 0 0 10 10 8 1 Tetratricopeptide repeat RNA_helicase PF00910.22 EFC49156.1 - 0.0078 16.6 0.0 0.064 13.7 0.0 2.7 2 0 0 2 2 1 1 RNA helicase KAP_NTPase PF07693.14 EFC49156.1 - 0.0084 15.4 0.0 0.39 9.9 0.0 3.1 2 1 1 3 3 3 1 KAP family P-loop domain TPR_11 PF13414.6 EFC49156.1 - 0.017 14.8 0.3 0.017 14.8 0.3 5.4 6 0 0 6 6 5 0 TPR repeat COX5A PF02284.16 EFC49156.1 - 0.025 14.6 2.1 6.4 6.8 0.1 3.7 3 0 0 3 3 3 0 Cytochrome c oxidase subunit Va NACHT PF05729.12 EFC49156.1 - 0.029 14.3 0.0 0.088 12.7 0.0 1.9 1 0 0 1 1 1 0 NACHT domain TPR_3 PF07720.12 EFC49156.1 - 0.029 14.4 22.5 1.6 8.8 0.1 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat AAA_16 PF13191.6 EFC49156.1 - 0.033 14.6 0.0 0.13 12.6 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 EFC49156.1 - 0.047 13.8 9.5 0.056 13.5 0.0 3.6 3 1 0 3 3 2 0 Helicase HerA, central domain T2SSE PF00437.20 EFC49156.1 - 0.061 12.4 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein BTAD PF03704.17 EFC49156.1 - 0.065 13.7 0.3 4.5 7.7 0.0 2.9 2 0 0 2 2 2 0 Bacterial transcriptional activator domain RsgA_GTPase PF03193.16 EFC49156.1 - 0.098 12.6 0.1 0.27 11.1 0.1 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EFC49156.1 - 0.16 12.5 0.6 1.4 9.5 0.0 2.9 3 0 0 3 3 2 0 AAA domain ANAPC3 PF12895.7 EFC49156.1 - 0.48 10.7 19.1 2.3 8.5 0.1 6.7 5 2 3 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 Lipase_GDSL PF00657.22 EFC49156.1 - 0.7 9.8 4.9 0.4 10.6 0.4 2.8 2 1 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase SHNi-TPR PF10516.9 EFC49156.1 - 0.97 8.9 5.1 20 4.8 0.1 3.8 4 0 0 4 4 3 0 SHNi-TPR TPR_17 PF13431.6 EFC49156.1 - 2.5 8.7 13.9 44 4.8 0.0 7.5 9 0 0 9 9 6 0 Tetratricopeptide repeat Sec5 PF15469.6 EFC49156.1 - 9.3 6.0 17.5 0.093 12.5 0.4 4.1 4 1 0 4 4 2 0 Exocyst complex component Sec5 Aldedh PF00171.22 EFC49157.1 - 4.7e-131 437.5 1.0 5.7e-131 437.2 1.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LZ3wCH PF18517.1 EFC49157.1 - 0.077 13.1 0.2 0.26 11.4 0.2 1.9 1 1 0 1 1 1 0 Leucine zipper with capping helix domain LuxC PF05893.14 EFC49157.1 - 0.079 12.0 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Ras PF00071.22 EFC49159.1 - 1.2e-12 47.7 0.2 2.5e-12 46.7 0.2 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49159.1 - 1.1e-08 35.3 0.0 4e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase F-box PF00646.33 EFC49159.1 - 1.6e-06 27.9 0.2 3.8e-06 26.6 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC49159.1 - 3.8e-06 26.7 0.8 8.6e-06 25.5 0.8 1.6 1 0 0 1 1 1 1 F-box-like AAA_14 PF13173.6 EFC49159.1 - 0.0026 17.8 0.1 0.029 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 EFC49159.1 - 0.0034 17.8 1.7 0.36 11.2 1.0 3.1 2 1 0 2 2 2 1 RNA helicase ABC_tran PF00005.27 EFC49159.1 - 0.0051 17.3 0.0 0.011 16.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 EFC49159.1 - 0.0087 16.6 0.0 0.043 14.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 EFC49159.1 - 0.033 14.3 0.5 0.5 10.5 0.0 2.8 3 1 0 3 3 3 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 EFC49159.1 - 0.077 12.7 0.2 0.14 11.9 0.2 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 EFC49159.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF808 PF05661.12 EFC49160.1 - 0.0018 17.4 0.4 0.0026 16.8 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF808) TraL PF07178.11 EFC49160.1 - 0.5 10.9 5.8 1.6 9.2 0.2 2.7 2 1 1 3 3 3 0 TraL protein ubiquitin PF00240.23 EFC49161.1 - 2.4e-20 72.0 0.0 4.4e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 EFC49161.1 - 8.7e-10 38.3 0.6 8.7e-10 38.3 0.6 2.7 2 0 0 2 2 2 1 UBA/TS-N domain STI1 PF17830.1 EFC49161.1 - 6.3e-09 35.6 53.3 1.3e-05 25.0 5.8 5.3 3 2 2 5 5 4 3 STI1 domain Rad60-SLD PF11976.8 EFC49161.1 - 8.3e-08 32.0 0.1 1.5e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 EFC49161.1 - 0.00011 22.6 0.1 0.00033 21.1 0.0 1.9 2 0 0 2 2 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC49161.1 - 0.001 19.2 0.1 0.0031 17.6 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 EFC49161.1 - 0.0011 19.5 0.8 0.0068 17.0 0.4 2.5 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 EFC49161.1 - 0.0013 18.6 1.3 0.0023 17.8 0.0 2.1 2 0 0 2 2 1 1 TANK binding kinase 1 ubiquitin-like domain RPN13_C PF16550.5 EFC49161.1 - 0.0024 18.0 8.1 0.11 12.6 4.3 2.8 2 0 0 2 2 2 1 UCH-binding domain Plexin_cytopl PF08337.12 EFC49161.1 - 0.019 13.7 0.8 0.04 12.6 0.8 1.5 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain Ubiquitin_4 PF18036.1 EFC49161.1 - 0.067 13.3 0.1 13 5.9 0.0 2.3 1 1 1 2 2 2 0 Ubiquitin-like domain HOIP-UBA PF16678.5 EFC49161.1 - 0.12 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 HOIP UBA domain pair RGCC PF15151.6 EFC49161.1 - 0.25 11.5 0.6 0.88 9.8 0.6 2.0 1 1 0 1 1 1 0 Response gene to complement 32 protein family ScsC_N PF18312.1 EFC49161.1 - 2.8 7.8 5.2 2.3e+02 1.7 0.0 5.2 6 0 0 6 6 6 0 Copper resistance protein ScsC N-terminal domain BSD PF03909.17 EFC49161.1 - 4.4 7.4 5.6 25 5.0 0.4 4.0 2 2 1 4 4 4 0 BSD domain GSHPx PF00255.19 EFC49162.1 - 7.1e-11 41.6 0.5 1.4e-09 37.5 0.5 2.8 1 1 0 1 1 1 1 Glutathione peroxidase F-box-like PF12937.7 EFC49163.1 - 0.0005 19.9 0.5 0.0044 16.9 0.0 2.4 2 0 0 2 2 2 1 F-box-like Uso1_p115_head PF04869.14 EFC49163.1 - 0.012 14.8 0.1 0.021 14.0 0.1 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, head region F-box PF00646.33 EFC49163.1 - 0.022 14.6 0.4 0.054 13.4 0.4 1.7 1 0 0 1 1 1 0 F-box domain Metallophos PF00149.28 EFC49164.1 - 6.4e-10 39.9 0.0 1.3e-09 38.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC49164.1 - 7.6e-06 26.2 0.0 2.5e-05 24.5 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TatD_DNase PF01026.21 EFC49164.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.3 1 1 0 1 1 1 0 TatD related DNase Bac_export_2 PF01312.19 EFC49164.1 - 0.11 11.7 0.4 0.22 10.7 0.2 1.6 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family ECH_1 PF00378.20 EFC49165.1 - 1.2e-81 273.8 2.3 1.4e-81 273.5 2.3 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 EFC49165.1 - 1.9e-36 126.3 1.8 5.7e-36 124.7 1.8 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 EFC49165.1 - 0.0091 16.0 0.6 0.17 11.9 0.0 2.6 3 0 0 3 3 3 1 Peptidase family S49 Ependymin PF00811.18 EFC49166.1 - 0.0011 19.3 1.9 0.0018 18.5 1.7 1.5 1 1 0 1 1 1 1 Ependymin DUF4064 PF13273.6 EFC49167.1 - 0.078 13.3 2.7 0.28 11.5 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) DUF3907 PF13047.6 EFC49167.1 - 0.12 12.4 4.1 0.22 11.5 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3907) AI-2E_transport PF01594.16 EFC49167.1 - 4.1 6.5 10.1 1.1 8.3 0.4 2.6 3 0 0 3 3 3 0 AI-2E family transporter FolB PF02152.18 EFC49168.1 - 1e-22 80.8 0.3 1.2e-22 80.6 0.3 1.1 1 0 0 1 1 1 1 Dihydroneopterin aldolase IQ PF00612.27 EFC49169.1 - 0.0018 17.9 0.2 0.0049 16.6 0.2 1.8 1 0 0 1 1 1 1 IQ calmodulin-binding motif ATG_C PF09333.11 EFC49169.1 - 0.025 14.9 0.0 0.068 13.5 0.0 1.7 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain DUF1460 PF07313.12 EFC49169.1 - 0.33 10.3 6.4 0.52 9.7 6.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) Hom_end_hint PF05203.16 EFC49169.1 - 1.5 8.8 8.6 2.1 8.2 8.6 1.3 1 0 0 1 1 1 0 Hom_end-associated Hint Response_reg PF00072.24 EFC49171.1 - 4.1e-17 62.4 0.6 7.1e-17 61.6 0.6 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 EFC49171.1 - 6.7e-17 62.0 0.1 1.3e-16 61.1 0.1 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 EFC49171.1 - 1.5e-08 34.6 0.1 3.1e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain DUF4234 PF14018.6 EFC49171.1 - 0.59 10.3 0.0 0.59 10.3 0.0 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) WD40 PF00400.32 EFC49172.1 - 0.05 14.5 0.7 6.9 7.7 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Presenilin PF01080.17 EFC49172.1 - 1 8.0 17.8 1.9 7.2 17.8 1.5 1 0 0 1 1 1 0 Presenilin CaKB PF03185.15 EFC49174.1 - 0.76 9.4 6.2 2.3 7.9 0.8 2.4 2 1 0 2 2 2 0 Calcium-activated potassium channel, beta subunit Peptidase_S8 PF00082.22 EFC49175.1 - 1.4e-39 136.1 2.7 3e-39 135.1 2.7 1.5 1 0 0 1 1 1 1 Subtilase family Pilin_N PF07790.11 EFC49175.1 - 0.082 13.8 0.7 0.66 10.9 0.2 2.7 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal TGBp3 PF02495.17 EFC49175.1 - 0.35 10.6 2.8 1.1 9.0 0.0 2.5 2 0 0 2 2 2 0 Triple gene block 3 Glyco_transf_20 PF00982.21 EFC49176.1 - 2.3e-166 554.2 0.0 2.6e-166 554.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 EFC49176.1 - 2.1e-05 24.1 0.0 8.6e-05 22.1 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 EFC49176.1 - 0.0028 17.4 0.1 0.0046 16.7 0.1 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain DUF2431 PF10354.9 EFC49176.1 - 0.048 13.9 0.0 0.23 11.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) Trehalose_PPase PF02358.16 EFC49177.1 - 5.4e-50 169.7 0.0 5.9e-50 169.6 0.0 1.0 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 EFC49177.1 - 6.2e-07 29.4 0.0 0.0019 18.0 0.0 2.1 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 EFC49177.1 - 0.0026 17.3 0.0 0.085 12.4 0.0 2.2 2 0 0 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase hSac2 PF12456.8 EFC49178.1 - 4e-09 36.2 0.7 1.3e-07 31.4 0.1 2.7 2 0 0 2 2 2 1 Inositol phosphatase Arm PF00514.23 EFC49178.1 - 0.0085 16.1 0.1 2.3 8.4 0.0 4.2 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HSDR_N_2 PF13588.6 EFC49178.1 - 0.12 12.3 0.8 0.79 9.7 0.2 2.7 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) FliL PF03748.14 EFC49178.1 - 0.15 12.7 1.9 0.7 10.5 0.3 2.9 2 0 0 2 2 2 0 Flagellar basal body-associated protein FliL SNF2_N PF00176.23 EFC49179.1 - 3e-68 230.1 3.5 5.3e-68 229.3 2.3 2.0 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC49179.1 - 2.4e-20 72.9 2.4 5.3e-20 71.8 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBINO PF13892.6 EFC49179.1 - 7.5e-17 61.9 18.2 7.5e-17 61.9 18.2 2.9 3 1 0 3 3 3 1 DNA-binding domain DEAD PF00270.29 EFC49179.1 - 8.8e-07 28.9 0.4 9.7e-06 25.5 0.0 3.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase NPV_P10 PF05531.12 EFC49179.1 - 0.14 12.7 2.0 3.7 8.1 0.1 3.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Val_tRNA-synt_C PF10458.9 EFC49179.1 - 0.54 10.6 8.5 2.7 8.3 8.5 2.3 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm DUF92 PF01940.16 EFC49180.1 - 3.1e-67 226.5 0.6 3.6e-67 226.2 0.6 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 DUF3169 PF11368.8 EFC49180.1 - 0.016 14.8 1.4 0.026 14.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) Rhodanese PF00581.20 EFC49181.1 - 1e-12 48.5 0.0 1.2e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain BPL_LplA_LipB PF03099.19 EFC49181.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 1 0 1 1 1 0 Biotin/lipoate A/B protein ligase family F-box PF00646.33 EFC49182.1 - 0.046 13.6 0.2 0.13 12.2 0.2 1.7 1 0 0 1 1 1 0 F-box domain Peptidase_C1 PF00112.23 EFC49183.1 - 4.8e-52 177.2 3.9 6.2e-52 176.8 3.9 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC49183.1 - 0.0089 14.8 0.1 0.014 14.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase C1-like family RRF PF01765.19 EFC49184.1 - 0.014 15.4 0.5 0.019 14.9 0.5 1.3 1 0 0 1 1 1 0 Ribosome recycling factor Polysacc_deac_3 PF15421.6 EFC49184.1 - 0.032 12.7 0.1 0.048 12.2 0.1 1.4 1 1 0 1 1 1 0 Putative polysaccharide deacetylase NLRC4_HD PF17889.1 EFC49184.1 - 0.035 14.4 1.3 0.057 13.8 0.5 1.6 2 0 0 2 2 2 0 NLRC4 helical domain Type_III_YscX PF09474.10 EFC49184.1 - 0.037 14.3 0.0 0.052 13.9 0.0 1.2 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) MCR_C PF04609.12 EFC49184.1 - 0.044 12.8 0.6 0.086 11.9 0.2 1.6 1 1 1 2 2 2 0 Methyl-coenzyme M reductase operon protein C Cyclase_polyket PF04673.12 EFC49184.1 - 0.078 13.2 0.3 0.18 12.1 0.2 1.6 1 1 1 2 2 2 0 Polyketide synthesis cyclase NYD-SP28_assoc PF14775.6 EFC49184.1 - 0.089 12.9 0.7 0.15 12.2 0.7 1.3 1 0 0 1 1 1 0 Sperm tail C-terminal domain PdaC PF13739.6 EFC49184.1 - 0.23 12.4 3.2 4.1 8.4 3.2 2.1 1 1 0 1 1 1 0 Deacetylase PdaC LRR_4 PF12799.7 EFC49185.1 - 2.1e-06 28.0 6.2 5.7e-06 26.6 2.5 2.8 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC49185.1 - 1.2e-05 24.9 0.0 2.8e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 EFC49185.1 - 0.0052 16.5 5.2 0.045 13.5 1.6 2.5 1 1 0 2 2 2 1 Leucine rich repeat LRR_6 PF13516.6 EFC49185.1 - 0.4 10.9 5.0 12 6.3 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich repeat Guanylate_cyc PF00211.20 EFC49186.1 - 1.8e-54 184.2 0.0 4e-54 183.0 0.0 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC49186.1 - 1.7e-17 63.6 2.0 2.4e-17 63.1 0.2 2.3 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC49186.1 - 3.1e-08 33.6 0.0 1.1e-07 31.8 0.0 2.0 2 0 0 2 2 2 1 PAS fold Bromo_TP PF07524.13 EFC49186.1 - 0.017 15.1 1.5 0.15 12.0 0.0 3.1 3 0 0 3 3 3 0 Bromodomain associated PAS_8 PF13188.7 EFC49186.1 - 0.033 14.2 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain PAS_4 PF08448.10 EFC49186.1 - 0.067 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 PAS fold DUF3496 PF12001.8 EFC49186.1 - 5.6 7.4 6.0 9.1 6.7 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3496) Pept_tRNA_hydro PF01195.19 EFC49187.1 - 7.8e-45 152.9 0.0 1.6e-44 151.9 0.0 1.5 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase Stk19 PF10494.9 EFC49188.1 - 4e-22 79.1 2.8 9.1e-22 77.9 2.8 1.5 1 1 0 1 1 1 1 Serine-threonine protein kinase 19 Sld3_N PF18523.1 EFC49188.1 - 0.26 11.4 5.8 0.52 10.4 1.7 2.8 2 1 0 2 2 2 0 Sld3 N-terminal domain SOG2 PF10428.9 EFC49188.1 - 2.1 7.5 18.7 3.4 6.8 18.7 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Herpes_pp85 PF04637.12 EFC49188.1 - 4.2 5.7 17.7 9.4 4.5 17.7 1.6 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) HATPase_c PF02518.26 EFC49189.1 - 1.5e-29 102.8 0.1 2.9e-29 101.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC49189.1 - 9.9e-19 67.6 0.0 1.9e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC49189.1 - 5.7e-13 48.7 0.1 8.3e-12 45.0 0.1 2.4 1 1 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EFC49189.1 - 0.00078 19.3 0.0 0.0017 18.2 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase fragilysinNterm PF16376.5 EFC49189.1 - 0.055 13.2 3.1 0.49 10.1 0.0 3.4 4 0 0 4 4 4 0 N-terminal domain of fragilysin p450 PF00067.22 EFC49190.1 - 8.5e-63 212.7 0.0 1.2e-62 212.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 VAPB_antitox PF02697.14 EFC49190.1 - 0.015 16.0 2.0 0.42 11.4 1.2 3.0 2 1 1 3 3 3 0 Putative antitoxin Guanylate_cyc PF00211.20 EFC49192.1 - 0.056 13.1 1.2 0.12 12.0 1.2 1.5 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain F-box PF00646.33 EFC49194.1 - 0.0018 18.1 0.0 0.0055 16.6 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 EFC49194.1 - 0.034 14.0 0.0 0.084 12.8 0.0 1.6 1 0 0 1 1 1 0 F-box-like CS PF04969.16 EFC49195.1 - 1.2e-10 42.2 0.3 2.7e-10 41.1 0.3 1.6 1 0 0 1 1 1 1 CS domain DUF4834 PF16118.5 EFC49195.1 - 7.6 7.6 11.5 16 6.5 11.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) YacG PF03884.14 EFC49195.1 - 8.8 6.1 8.1 4.8 7.0 3.5 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG zf-C3HC4 PF00097.25 EFC49196.1 - 6.5e-12 45.1 8.4 1.8e-11 43.7 8.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 EFC49196.1 - 1.9e-11 43.6 9.3 4.5e-11 42.4 9.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC49196.1 - 4e-10 39.5 7.3 4e-10 39.5 7.3 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 EFC49196.1 - 1.4e-08 34.5 6.9 3.1e-08 33.4 6.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC49196.1 - 2.3e-08 34.2 8.0 2.3e-08 34.2 8.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 EFC49196.1 - 4.3e-08 33.2 8.6 1.2e-07 31.7 8.6 1.9 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 EFC49196.1 - 3.2e-07 30.2 8.1 8.3e-07 28.9 8.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 EFC49196.1 - 0.00034 20.4 5.7 0.00034 20.4 5.7 2.3 2 0 0 2 2 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 EFC49196.1 - 0.0024 17.6 4.8 0.0024 17.6 4.8 2.5 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 EFC49196.1 - 0.0089 15.9 7.3 0.0089 15.9 7.3 2.6 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 EFC49196.1 - 0.02 15.2 8.0 0.18 12.1 8.0 2.6 1 1 0 1 1 1 0 RING-H2 zinc finger domain FYVE PF01363.21 EFC49196.1 - 0.032 14.4 3.3 0.1 12.7 3.3 1.9 1 0 0 1 1 1 0 FYVE zinc finger zf-ANAPC11 PF12861.7 EFC49196.1 - 0.08 13.0 2.3 0.54 10.3 1.9 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pterin_bind PF00809.22 EFC49196.1 - 0.096 12.3 0.0 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 Pterin binding enzyme zf-RING_6 PF14835.6 EFC49196.1 - 0.47 10.4 1.9 1.4 8.9 1.9 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-MIZ PF02891.20 EFC49196.1 - 0.58 9.9 5.7 1.4 8.7 5.7 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_10 PF16685.5 EFC49196.1 - 1.3 9.2 6.1 4.7 7.4 6.1 2.0 1 1 0 1 1 1 0 zinc RING finger of MSL2 Zn-C2H2_12 PF18112.1 EFC49196.1 - 8.1 7.0 10.1 18 5.9 0.7 3.4 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Myb_DNA-binding PF00249.31 EFC49197.1 - 5.6e-14 52.1 0.1 9.9e-14 51.3 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC49197.1 - 0.00032 20.9 0.3 0.0009 19.5 0.3 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain IMCp PF12314.8 EFC49197.1 - 0.036 14.3 2.1 0.071 13.4 0.1 2.1 2 0 0 2 2 2 0 Inner membrane complex protein DNA_processg_A PF02481.15 EFC49197.1 - 0.09 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 DNA recombination-mediator protein A Dynamin_N PF00350.23 EFC49197.1 - 0.18 11.8 9.3 0.11 12.6 1.2 3.1 3 0 0 3 3 3 0 Dynamin family SPT6_acidic PF14632.6 EFC49197.1 - 0.7 10.5 10.8 3 8.5 4.7 2.6 2 0 0 2 2 2 0 Acidic N-terminal SPT6 DUF1079 PF06435.11 EFC49197.1 - 2.6 8.4 5.5 0.3 11.3 0.4 2.2 2 0 0 2 2 2 0 Repeat of unknown function (DUF1079) DUF3112 PF11309.8 EFC49197.1 - 6.5 6.1 4.8 4.5 6.7 2.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) Pkinase PF00069.25 EFC49198.1 - 1e-51 175.9 0.0 1.8e-51 175.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49198.1 - 1.8e-48 165.1 0.0 6.9e-43 146.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC49198.1 - 0.0078 15.2 0.0 0.017 14.1 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC49198.1 - 0.31 10.9 0.0 0.51 10.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Insulin_TMD PF17870.1 EFC49198.1 - 1.8 8.7 4.6 6.4 6.9 4.6 1.9 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Aminotran_1_2 PF00155.21 EFC49199.1 - 1.3e-45 156.2 0.1 1.6e-45 155.9 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PUF PF00806.19 EFC49199.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat RWP-RK PF02042.15 EFC49200.1 - 1.9e-21 75.7 0.0 3.7e-21 74.8 0.0 1.5 1 0 0 1 1 1 1 RWP-RK domain HTH_17 PF12728.7 EFC49200.1 - 0.16 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain FtsJ PF01728.19 EFC49201.1 - 2.6e-56 190.5 0.1 5.4e-56 189.5 0.1 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Spb1_C PF07780.12 EFC49201.1 - 1e-46 159.3 27.0 1e-46 159.3 27.0 4.1 4 0 0 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.8 EFC49201.1 - 9.2e-42 142.6 16.9 9.2e-42 142.6 16.9 5.4 3 1 0 3 3 3 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 EFC49201.1 - 0.03 14.2 0.0 0.35 10.7 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain DUF1963 PF09234.10 EFC49202.1 - 1.2e-15 58.6 0.1 1.2e-15 58.6 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1963) F-box-like PF12937.7 EFC49202.1 - 0.0036 17.2 0.4 0.0072 16.2 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC49202.1 - 0.0038 17.1 0.0 0.0094 15.8 0.0 1.6 1 0 0 1 1 1 1 F-box domain DUF3510 PF12022.8 EFC49202.1 - 0.11 12.9 1.8 0.25 11.7 1.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) DNA_pack_N PF02500.15 EFC49202.1 - 0.11 12.3 1.0 0.34 10.7 0.2 1.9 2 0 0 2 2 2 0 Probable DNA packing protein, N-terminus Ras PF00071.22 EFC49203.1 - 1.8e-53 180.5 0.2 2.2e-53 180.2 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49203.1 - 1.1e-24 86.9 0.0 1.6e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49203.1 - 9.9e-12 44.6 0.1 1.2e-11 44.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC49203.1 - 0.00013 21.4 0.0 0.00017 21.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC49203.1 - 0.0044 16.6 0.0 0.0073 15.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC49203.1 - 0.0078 16.3 0.0 0.013 15.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC49203.1 - 0.024 14.5 0.0 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EFC49203.1 - 0.045 13.5 0.4 1.8 8.3 0.4 2.8 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Mito_fiss_Elm1 PF06258.11 EFC49203.1 - 0.054 12.6 0.0 0.11 11.6 0.0 1.4 1 1 0 1 1 1 0 Mitochondrial fission ELM1 LRR_6 PF13516.6 EFC49204.1 - 1.1e-36 121.7 21.1 0.0019 18.1 0.0 12.2 12 0 0 12 12 12 11 Leucine Rich repeat LRR_4 PF12799.7 EFC49204.1 - 4.4e-27 93.7 34.9 1.6e-05 25.2 0.7 8.4 3 2 4 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49204.1 - 8.1e-27 92.8 21.4 9.8e-08 31.7 1.1 6.4 3 1 4 7 7 7 7 Leucine rich repeat LRR_1 PF00560.33 EFC49204.1 - 3.7e-10 38.9 12.3 3.1 8.7 0.1 9.6 7 2 0 7 7 7 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC49204.1 - 1.3e-05 24.8 7.1 0.053 13.0 0.3 3.5 1 1 1 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC49204.1 - 0.00013 21.8 1.0 10 5.9 0.1 5.0 2 2 3 5 5 5 2 Domain of unknown function (DUF4347) 2-Hacid_dh PF00389.30 EFC49204.1 - 0.028 14.1 0.1 6.9 6.3 0.0 2.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain LRR_5 PF13306.6 EFC49204.1 - 0.048 13.6 14.2 1.1 9.2 1.0 3.4 1 1 1 3 3 3 0 BspA type Leucine rich repeat region (6 copies) Ribosomal_S19 PF00203.21 EFC49205.1 - 0.12 12.3 0.0 0.31 10.9 0.0 1.7 1 0 0 1 1 1 0 Ribosomal protein S19 Ras PF00071.22 EFC49206.1 - 3.8e-63 211.9 0.8 4.4e-63 211.7 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49206.1 - 4.1e-35 120.6 0.2 7.4e-35 119.8 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49206.1 - 7e-16 58.2 0.1 9e-16 57.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC49206.1 - 7.3e-06 26.0 0.6 1.2e-05 25.4 0.1 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC49206.1 - 0.00022 21.2 0.5 0.018 15.0 0.1 2.3 1 1 1 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 EFC49206.1 - 0.00051 20.5 0.0 0.00082 19.8 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 EFC49206.1 - 0.00064 19.3 0.1 0.0092 15.5 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 EFC49206.1 - 0.0027 17.5 0.8 0.0052 16.5 0.8 1.7 1 1 0 1 1 1 1 AAA domain Gtr1_RagA PF04670.12 EFC49206.1 - 0.0055 16.1 0.1 0.0082 15.5 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Septin PF00735.18 EFC49206.1 - 0.0087 15.4 0.4 0.024 13.9 0.0 1.9 3 0 0 3 3 3 1 Septin AAA_22 PF13401.6 EFC49206.1 - 0.019 15.3 0.4 0.093 13.0 0.1 2.3 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 EFC49206.1 - 0.057 12.9 0.0 0.096 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 EFC49206.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 EFC49206.1 - 0.11 11.9 0.3 0.37 10.2 0.0 1.9 1 1 0 2 2 2 0 Signal recognition particle receptor beta subunit ATPase_2 PF01637.18 EFC49206.1 - 0.11 12.3 0.6 0.36 10.7 0.5 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea CPL PF08144.11 EFC49206.1 - 0.16 12.3 0.2 0.27 11.6 0.2 1.3 1 0 0 1 1 1 0 CPL (NUC119) domain ABC_tran PF00005.27 EFC49206.1 - 0.16 12.4 0.7 0.26 11.8 0.7 1.6 1 1 0 1 1 1 0 ABC transporter PRK PF00485.18 EFC49206.1 - 0.35 10.6 1.7 1.8 8.2 0.3 2.4 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF2347 PF09804.9 EFC49207.1 - 0.0092 15.6 0.2 0.011 15.3 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4698 PF15769.5 EFC49208.1 - 0.062 12.4 1.4 0.067 12.2 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) DUF1635 PF07795.11 EFC49208.1 - 4.2 7.2 6.6 5.6 6.8 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) RasGAP PF00616.19 EFC49209.1 - 9.7e-33 113.6 3.9 1.9e-21 76.7 0.0 2.9 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase PH PF00169.29 EFC49209.1 - 1.8e-09 38.0 1.8 0.00044 20.7 0.1 3.0 2 1 0 2 2 2 2 PH domain SesA PF17107.5 EFC49209.1 - 0.075 13.2 1.0 1.2 9.3 0.3 2.7 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases FAD_binding_3 PF01494.19 EFC49210.1 - 2.1e-17 63.4 0.1 9.9e-16 57.9 0.1 2.8 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 EFC49210.1 - 0.00066 19.0 1.0 0.027 13.7 0.2 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 EFC49210.1 - 0.0025 17.1 3.9 0.068 12.4 2.2 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 EFC49210.1 - 0.047 13.9 0.2 0.1 12.9 0.2 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 EFC49210.1 - 0.098 11.7 1.1 0.15 11.1 1.1 1.2 1 0 0 1 1 1 0 FAD binding domain Coatomer_E PF04733.14 EFC49212.1 - 4.2e-71 239.7 1.7 5e-71 239.5 1.7 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 EFC49212.1 - 5.4e-05 23.6 0.0 0.66 10.5 0.0 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49212.1 - 0.073 13.4 0.2 0.96 9.8 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.7 EFC49213.1 - 5.7e-26 90.1 60.0 4.2e-06 27.0 7.2 8.6 3 2 7 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49213.1 - 1.9e-21 75.6 56.0 2.6e-10 39.9 0.2 8.2 4 3 6 10 10 10 9 Leucine rich repeat LRR_9 PF14580.6 EFC49213.1 - 6.8e-10 38.7 23.8 0.003 17.1 2.1 4.5 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 EFC49213.1 - 0.31 11.7 44.4 6.4 7.7 0.9 10.9 11 1 0 11 11 11 0 Leucine Rich Repeat DASH_Dam1 PF08653.10 EFC49213.1 - 3.6 7.5 9.2 2.4 8.0 0.6 4.0 4 0 0 4 4 4 0 DASH complex subunit Dam1 tRNA-synt_2 PF00152.20 EFC49214.1 - 9.6e-78 261.4 0.2 9.6e-78 261.4 0.2 1.4 2 0 0 2 2 2 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 EFC49214.1 - 1.8e-09 37.5 0.0 3.2e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 EFC49214.1 - 1.6e-06 27.8 0.0 0.0044 16.5 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DUF1664 PF07889.12 EFC49214.1 - 0.22 11.6 0.8 0.45 10.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) SbsC_C PF18058.1 EFC49214.1 - 3.1 8.1 8.0 5.2 7.3 3.4 3.0 3 0 0 3 3 3 0 SbsC C-terminal domain Ras PF00071.22 EFC49215.1 - 3.3e-40 137.3 1.1 9.7e-38 129.3 1.1 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC49215.1 - 4.7e-17 62.3 0.4 1.5e-11 44.6 0.1 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49215.1 - 0.00027 20.4 0.1 0.026 14.0 0.1 2.2 1 1 1 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC49215.1 - 0.00084 19.4 0.2 0.0014 18.7 0.2 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC49215.1 - 0.0016 18.4 0.0 0.38 10.7 0.0 2.3 1 1 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 EFC49215.1 - 0.0029 17.0 0.3 0.13 11.6 0.1 2.1 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 EFC49215.1 - 0.0058 16.4 0.1 0.0085 15.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain FeoB_N PF02421.18 EFC49215.1 - 0.0098 15.4 0.0 1.8 8.0 0.0 2.3 1 1 1 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFC49215.1 - 0.011 15.3 0.0 1.7 8.1 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain SRPRB PF09439.10 EFC49215.1 - 0.012 15.1 0.0 0.022 14.2 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MCM PF00493.23 EFC49215.1 - 0.017 14.2 0.0 0.029 13.5 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_15 PF13175.6 EFC49215.1 - 0.019 14.7 6.4 0.023 14.4 6.4 1.0 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 EFC49215.1 - 0.019 14.2 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 Septin PRK PF00485.18 EFC49215.1 - 0.028 14.2 0.3 5.8 6.6 0.1 2.2 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_7 PF12775.7 EFC49215.1 - 0.034 13.7 0.0 0.049 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 EFC49215.1 - 0.045 14.3 0.1 0.8 10.2 0.0 2.1 1 1 1 2 2 2 0 ABC transporter TniB PF05621.11 EFC49215.1 - 0.047 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 EFC49215.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain KASH_CCD PF14662.6 EFC49217.1 - 0.00045 20.1 9.2 0.00045 20.1 9.2 1.8 2 0 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH ALIX_LYPXL_bnd PF13949.6 EFC49217.1 - 0.0053 16.1 9.4 0.0075 15.6 9.4 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV JIP_LZII PF16471.5 EFC49217.1 - 0.007 16.5 3.9 0.024 14.8 3.9 2.0 1 0 0 1 1 1 1 JNK-interacting protein leucine zipper II zf-CpG_bind_C PF12269.8 EFC49217.1 - 0.017 14.9 4.3 0.021 14.6 0.7 2.5 1 1 2 3 3 3 0 CpG binding protein zinc finger C terminal domain APG6_N PF17675.1 EFC49217.1 - 0.018 15.6 8.7 0.023 15.2 5.9 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 EFC49217.1 - 0.048 14.6 1.8 0.048 14.6 1.8 3.0 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF382 PF04037.13 EFC49217.1 - 0.12 12.5 3.8 0.11 12.6 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF382) Syntaxin-6_N PF09177.11 EFC49217.1 - 0.26 11.9 7.0 2.1 8.9 7.0 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.12 EFC49217.1 - 0.26 11.3 5.6 0.7 9.9 5.5 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 EFC49217.1 - 0.35 10.1 3.6 0.15 11.3 0.4 1.8 2 0 0 2 2 2 0 TMPIT-like protein HALZ PF02183.18 EFC49217.1 - 0.38 11.0 6.4 0.24 11.6 1.4 2.9 2 1 0 2 2 1 0 Homeobox associated leucine zipper Lectin_N PF03954.14 EFC49217.1 - 0.44 10.3 5.4 0.22 11.3 2.3 2.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain TMF_TATA_bd PF12325.8 EFC49217.1 - 0.44 10.8 8.6 0.087 13.1 1.5 2.7 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding USP8_interact PF08941.10 EFC49217.1 - 0.95 9.3 5.4 2.8 7.7 0.5 2.3 2 0 0 2 2 2 0 USP8 interacting Snapin_Pallidin PF14712.6 EFC49217.1 - 1.1 9.7 8.3 0.41 11.1 2.7 2.7 1 1 1 2 2 2 0 Snapin/Pallidin LMBR1 PF04791.16 EFC49217.1 - 1.6 7.5 3.9 1.9 7.3 3.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 EFC49217.1 - 1.9 8.5 4.6 2.2 8.4 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Tup_N PF08581.10 EFC49217.1 - 4.8 7.6 12.1 0.24 11.7 2.6 2.8 3 0 0 3 3 3 0 Tup N-terminal LPP PF04728.13 EFC49217.1 - 5 7.6 8.6 4.1 7.9 3.2 3.3 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Syntaxin_2 PF14523.6 EFC49217.1 - 8.3 6.8 15.4 0.23 11.9 6.7 2.7 3 1 0 3 3 3 0 Syntaxin-like protein zf-C4H2 PF10146.9 EFC49217.1 - 8.6 6.6 9.8 16 5.7 9.2 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein UDPGT PF00201.18 EFC49219.1 - 6.8e-16 58.1 0.2 1.4e-15 57.1 0.2 1.6 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 EFC49219.1 - 0.0015 18.5 0.0 0.0043 17.1 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain CH PF00307.31 EFC49221.1 - 4.2e-18 65.5 0.4 8.3e-17 61.3 0.0 3.2 3 1 2 5 5 5 1 Calponin homology (CH) domain SHOCT PF09851.9 EFC49221.1 - 1.4e-13 50.1 34.8 0.0003 20.4 0.0 6.8 7 0 0 7 7 7 4 Short C-terminal domain GvpG PF05120.12 EFC49221.1 - 2.1e-08 34.0 18.3 0.046 13.7 0.2 5.0 5 0 0 5 5 5 3 Gas vesicle protein G DUF1707 PF08044.11 EFC49221.1 - 0.00058 19.9 0.0 3.1 8.0 0.0 4.4 4 0 0 4 4 4 1 Domain of unknown function (DUF1707) PRKG1_interact PF15898.5 EFC49221.1 - 0.0057 17.5 3.0 0.0057 17.5 3.0 4.4 2 1 2 4 4 3 1 cGMP-dependent protein kinase interacting domain hnRNP_Q_AcD PF18360.1 EFC49221.1 - 0.076 13.0 2.1 43 4.2 0.1 4.0 4 0 0 4 4 4 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain VPS28 PF03997.12 EFC49221.1 - 0.24 11.1 20.9 0.83 9.3 6.0 4.9 3 1 0 5 5 5 0 VPS28 protein DUF910 PF06014.11 EFC49221.1 - 0.42 10.7 17.5 19 5.3 0.8 5.2 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF910) DUF4061 PF13270.6 EFC49221.1 - 1.1 9.6 9.3 0.45 10.9 4.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) Peptidase_M61 PF05299.12 EFC49221.1 - 1.1 9.6 12.2 3.7 8.0 1.0 3.7 2 1 2 4 4 4 0 M61 glycyl aminopeptidase DMAP_binding PF06464.11 EFC49221.1 - 1.6 9.6 40.9 0.24 12.2 18.8 4.7 2 1 2 4 4 4 0 DMAP1-binding Domain Phage_XkdX PF09693.10 EFC49221.1 - 1.6 8.8 8.7 2.1 8.4 0.0 4.2 5 0 0 5 5 5 0 Phage uncharacterised protein (Phage_XkdX) CdvA PF18822.1 EFC49221.1 - 4.8 7.0 38.8 0.075 12.9 13.0 5.7 5 1 0 5 5 5 0 CdvA-like coiled-coil domain E1_dh PF00676.20 EFC49221.1 - 8.1 5.3 16.9 6.1 5.7 1.7 3.5 2 2 2 4 4 4 0 Dehydrogenase E1 component Peptidase_M16 PF00675.20 EFC49221.1 - 9.7 6.2 12.9 3.9 7.4 0.8 3.3 2 1 1 3 3 3 0 Insulinase (Peptidase family M16) Exo_endo_phos PF03372.23 EFC49222.1 - 4.1e-06 26.5 0.0 1.8e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family bMG10 PF17973.1 EFC49223.1 - 6.1e-32 110.6 0.1 1.6e-31 109.2 0.1 1.8 1 0 0 1 1 1 1 Bacterial Alpha-2-macroglobulin MG10 domain A2M_BRD PF07703.14 EFC49223.1 - 4.6e-16 59.4 1.1 5.5e-15 55.9 0.0 3.2 3 0 0 3 3 3 1 Alpha-2-macroglobulin bait region domain MG2 PF01835.19 EFC49223.1 - 2.8e-13 50.1 0.1 3.8e-11 43.3 0.0 4.1 4 0 0 4 4 3 1 MG2 domain A2M PF00207.22 EFC49223.1 - 8.1e-12 44.8 0.0 5.8e-11 42.1 0.0 2.5 2 0 0 2 2 2 1 Alpha-2-macroglobulin family Big_1 PF02369.16 EFC49223.1 - 1.4e-05 25.0 5.6 0.0068 16.4 0.9 4.5 4 0 0 4 4 4 2 Bacterial Ig-like domain (group 1) bMG3 PF11974.8 EFC49223.1 - 0.00046 20.2 0.5 0.031 14.3 0.0 3.3 3 1 0 3 3 3 1 Bacterial alpha-2-macroglobulin MG3 domain CarboxypepD_reg PF13620.6 EFC49223.1 - 0.013 15.7 0.9 0.11 12.7 0.3 2.8 2 0 0 2 2 2 0 Carboxypeptidase regulatory-like domain DUF824 PF05688.11 EFC49223.1 - 0.033 14.0 2.9 5.8 6.8 0.2 3.6 3 0 0 3 3 3 0 Salmonella repeat of unknown function (DUF824) DUF4198 PF10670.9 EFC49223.1 - 0.042 14.2 0.1 0.21 12.0 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4198) DUF11 PF01345.18 EFC49223.1 - 0.044 14.1 0.1 0.27 11.6 0.1 2.4 2 0 0 2 2 1 0 Domain of unknown function DUF11 ZirS_C PF16583.5 EFC49223.1 - 0.057 13.0 0.9 0.21 11.2 0.4 2.2 2 0 0 2 2 2 0 Zinc-regulated secreted antivirulence protein C-terminal domain YtkA PF13115.6 EFC49223.1 - 0.097 13.3 0.3 8.8 7.0 0.0 2.9 2 0 0 2 2 2 0 YtkA-like RGS PF00615.19 EFC49225.1 - 3.8e-08 33.6 4.2 7.4e-08 32.7 4.2 1.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain Macscav_rec PF03523.13 EFC49225.1 - 0.006 16.5 0.2 0.015 15.2 0.2 1.6 1 0 0 1 1 1 1 Macrophage scavenger receptor Peptidase_M28 PF04389.17 EFC49226.1 - 2.4e-36 125.3 0.0 2.9e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 RUN PF02759.19 EFC49227.1 - 6.8e-18 64.9 6.3 6.5e-15 55.3 0.1 4.3 4 0 0 4 4 4 2 RUN domain PH PF00169.29 EFC49227.1 - 2e-07 31.5 0.4 0.00012 22.5 0.0 3.4 3 0 0 3 3 3 2 PH domain DUF1843 PF08898.10 EFC49227.1 - 0.18 12.3 1.4 48 4.5 0.0 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF1843) Carm_PH PF17888.1 EFC49227.1 - 0.7 10.3 4.1 2 8.8 0.2 3.6 3 1 1 4 4 4 0 Carmil pleckstrin homology domain DUF3336 PF11815.8 EFC49228.1 - 3.2e-29 101.4 7.2 3.2e-29 101.4 7.2 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF3336) Patatin PF01734.22 EFC49228.1 - 1.2e-20 74.6 3.2 1.8e-20 74.0 0.1 2.3 2 0 0 2 2 2 1 Patatin-like phospholipase ALG3 PF05208.13 EFC49229.1 - 1.6e-25 90.3 9.3 4e-24 85.7 0.9 2.5 2 1 1 3 3 3 2 ALG3 protein Ald_Xan_dh_C2 PF02738.18 EFC49230.1 - 1.7e-158 528.5 0.0 5.7e-90 302.3 0.0 2.1 2 0 0 2 2 2 2 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 EFC49230.1 - 4.5e-35 120.9 0.0 1.9e-27 96.1 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain in molybdopterin dehydrogenase Fer2_2 PF01799.20 EFC49230.1 - 2.4e-28 97.9 0.0 5.6e-28 96.8 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain CO_deh_flav_C PF03450.17 EFC49230.1 - 7.7e-28 96.7 0.0 1.9e-27 95.4 0.0 1.7 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 EFC49230.1 - 1.3e-25 89.9 0.1 2.7e-25 88.8 0.1 1.6 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2 PF00111.27 EFC49230.1 - 4.4e-08 33.0 0.1 1.1e-07 31.7 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain DHODB_Fe-S_bind PF10418.9 EFC49230.1 - 0.025 14.4 0.8 0.085 12.7 0.8 1.9 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B DDHD PF02862.17 EFC49230.1 - 0.041 14.0 4.6 0.9 9.7 2.0 3.0 2 0 0 2 2 2 0 DDHD domain HABP4_PAI-RBP1 PF04774.15 EFC49230.1 - 4 8.3 11.9 0.35 11.7 2.3 2.8 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family RMI1_N PF08585.12 EFC49231.1 - 0.018 14.8 3.5 0.19 11.5 0.0 2.3 2 0 0 2 2 2 0 RecQ mediated genome instability protein Drc1-Sld2 PF11719.8 EFC49231.1 - 0.4 10.2 9.8 0.58 9.6 9.8 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein AMP-binding PF00501.28 EFC49232.1 - 2.9e-83 279.8 0.0 3.6e-83 279.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 EFC49232.1 - 1.3e-16 61.3 0.1 2.7e-16 60.3 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 EFC49232.1 - 1.3e-13 50.6 1.8 1.3e-13 50.6 1.8 2.5 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus AlaE PF06610.13 EFC49232.1 - 0.16 12.0 0.1 0.28 11.2 0.1 1.3 1 0 0 1 1 1 0 L-alanine exporter FAM183 PF14886.6 EFC49233.1 - 1.3e-08 35.6 9.2 1.5e-07 32.1 9.2 2.2 1 1 0 1 1 1 1 FAM183A and FAM183B related LLC1 PF14945.6 EFC49233.1 - 0.053 14.1 1.0 0.084 13.5 0.9 1.5 1 1 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein CAP_N PF01213.19 EFC49235.1 - 7.8e-66 222.7 0.2 1.1e-65 222.3 0.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 EFC49235.1 - 1.3e-54 184.0 3.4 2.1e-54 183.4 3.4 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 EFC49235.1 - 0.63 9.8 6.0 3.4 7.4 5.2 2.4 2 0 0 2 2 2 0 Tubulin binding cofactor C RCC1 PF00415.18 EFC49236.1 - 0.018 15.6 0.0 0.22 12.2 0.0 2.7 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Peptidase_C1 PF00112.23 EFC49237.1 - 1e-51 176.1 6.5 1.3e-51 175.8 6.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC49237.1 - 1.9e-06 26.9 0.7 0.032 13.0 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC49237.1 - 0.00011 22.0 0.1 0.00026 20.8 0.1 1.7 1 0 0 1 1 1 1 Peptidase family C1 propeptide UQ_con PF00179.26 EFC49238.1 - 5.3e-17 61.8 1.6 1.3e-16 60.5 0.2 2.1 2 1 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC49238.1 - 4.8e-06 26.8 1.0 1.9e-05 24.9 0.2 2.2 1 1 1 2 2 2 1 RWD domain MetOD2 PF18548.1 EFC49238.1 - 0.0048 17.0 1.2 0.011 15.8 0.3 1.9 2 0 0 2 2 2 1 Metanogen output domain 2 UQ_con PF00179.26 EFC49239.1 - 1.8e-16 60.1 0.1 2.5e-16 59.6 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UCH PF00443.29 EFC49239.1 - 0.0028 17.2 0.5 0.035 13.6 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 EFC49239.1 - 0.065 12.8 0.5 0.15 11.6 0.5 1.7 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Ribophorin_II PF05817.14 EFC49240.1 - 2.8e-127 425.9 14.8 3.3e-127 425.7 14.8 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Borrelia_REV PF03978.13 EFC49240.1 - 0.2 11.6 11.6 0.012 15.5 5.5 2.1 2 0 0 2 2 2 0 Borrelia burgdorferi REV protein M16C_assoc PF08367.11 EFC49241.1 - 4.5e-46 157.0 1.4 4.6e-46 157.0 0.2 1.7 2 0 0 2 2 2 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFC49241.1 - 5.8e-17 62.3 4.0 4.6e-11 43.1 0.3 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFC49241.1 - 2.1e-11 44.0 1.0 1.8e-09 37.8 0.0 3.8 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) MFS_1 PF07690.16 EFC49242.1 - 1.8e-27 96.2 17.5 2e-26 92.8 16.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PIN_4 PF13638.6 EFC49242.1 - 1e-25 90.5 0.2 1e-25 90.5 0.2 2.5 3 0 0 3 3 3 1 PIN domain FHA PF00498.26 EFC49242.1 - 4.9e-13 49.2 0.3 1.8e-12 47.4 0.1 2.2 2 0 0 2 2 2 1 FHA domain BRCT_2 PF16589.5 EFC49242.1 - 1.3e-07 31.9 0.7 1.8e-05 25.1 0.0 4.1 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 EFC49242.1 - 0.00022 21.5 4.9 0.32 11.4 0.1 3.8 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain OATP PF03137.20 EFC49242.1 - 0.00032 19.1 1.3 0.00032 19.1 1.3 3.3 3 1 1 4 4 4 1 Organic Anion Transporter Polypeptide (OATP) family MFS_3 PF05977.13 EFC49242.1 - 0.0025 16.3 1.4 0.004 15.6 1.4 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector EI24 PF07264.11 EFC49242.1 - 0.14 12.4 6.9 0.95 9.7 0.2 3.0 2 1 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) KCT2 PF17818.1 EFC49242.1 - 8.5 6.5 10.1 29 4.7 10.1 1.9 1 0 0 1 1 1 0 Keratinocyte-associated gene product Aa_trans PF01490.18 EFC49243.1 - 8e-19 67.6 33.9 7.6e-10 38.1 27.4 2.3 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 EFC49243.1 - 5.2e-06 25.7 30.0 0.0072 15.4 22.8 2.1 2 0 0 2 2 2 2 Tryptophan/tyrosine permease family UPF0239 PF06783.11 EFC49243.1 - 0.021 15.0 0.3 2.5 8.3 0.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) APG9 PF04109.16 EFC49244.1 - 8.9e-139 463.6 27.2 1.1e-138 463.2 27.2 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Peptidase_M17 PF00883.21 EFC49245.1 - 2.3e-110 368.8 0.0 3.1e-110 368.3 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 EFC49245.1 - 0.0073 16.2 0.3 0.11 12.4 0.3 2.7 2 1 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain Lip_prot_lig_C PF10437.9 EFC49245.1 - 0.077 13.0 0.0 0.65 10.0 0.0 2.5 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus Ras PF00071.22 EFC49246.1 - 7.1e-12 45.2 5.7 3.7e-09 36.4 3.4 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 EFC49246.1 - 0.0072 16.5 6.6 0.54 10.5 0.1 3.2 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase KAsynt_C_assoc PF16197.5 EFC49246.1 - 0.076 13.5 1.1 1.1 9.8 1.7 2.7 3 0 0 3 3 3 0 Ketoacyl-synthetase C-terminal extension Lys-AminoMut_A PF09043.11 EFC49246.1 - 0.21 10.0 4.9 0.35 9.3 4.9 1.2 1 0 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit F-box PF00646.33 EFC49248.1 - 0.0018 18.1 1.2 0.0036 17.1 0.3 2.1 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 EFC49248.1 - 0.0099 15.8 3.0 0.031 14.2 0.4 2.7 2 0 0 2 2 2 1 F-box-like RGS PF00615.19 EFC49249.1 - 0.0007 19.9 8.3 0.018 15.3 4.6 3.4 2 1 0 2 2 2 1 Regulator of G protein signaling domain SAM_1 PF00536.30 EFC49249.1 - 0.0032 17.9 0.2 0.0099 16.3 0.2 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 EFC49249.1 - 0.0059 16.7 0.2 0.024 14.7 0.2 2.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 EFC49249.1 - 0.014 15.6 0.1 0.042 14.1 0.1 1.8 1 0 0 1 1 1 0 Ste50p, sterile alpha motif RNB PF00773.19 EFC49250.1 - 6.7e-28 98.0 3.4 5.8e-23 81.7 0.3 3.3 1 1 1 2 2 2 2 RNB domain RhoGEF PF00621.20 EFC49251.1 - 3.8e-40 138.1 7.7 1.3e-39 136.4 7.7 1.9 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 EFC49251.1 - 3e-07 30.9 2.2 0.0033 17.9 0.1 3.3 3 0 0 3 3 3 2 PH domain PH_10 PF15411.6 EFC49251.1 - 1.3e-05 25.5 0.5 8.4e-05 22.8 0.5 2.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 EFC49251.1 - 0.0045 17.3 0.7 0.26 11.6 0.1 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain IQ PF00612.27 EFC49251.1 - 0.1 12.4 0.1 0.2 11.5 0.1 1.5 1 0 0 1 1 1 0 IQ calmodulin-binding motif Ribosomal_L11 PF00298.19 EFC49252.1 - 5.7e-11 42.8 0.0 9.9e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 EFC49252.1 - 0.026 14.3 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11, N-terminal domain DUF676 PF05057.14 EFC49253.1 - 1.2e-30 106.7 1.0 5e-30 104.6 1.0 2.0 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 EFC49253.1 - 1.8e-05 24.7 0.3 3.2e-05 23.9 0.3 1.5 1 1 0 1 1 1 1 Palmitoyl protein thioesterase UPF0227 PF05728.12 EFC49253.1 - 0.087 12.8 0.0 0.26 11.2 0.0 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0227) RGS PF00615.19 EFC49254.1 - 1.2e-19 70.8 7.6 1.2e-19 70.8 7.6 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain START PF01852.19 EFC49254.1 - 8.2e-05 22.1 0.0 0.00028 20.4 0.0 1.8 2 0 0 2 2 2 1 START domain G8 PF10162.9 EFC49255.1 - 1.8e-20 73.3 0.1 4.1e-20 72.1 0.1 1.6 1 0 0 1 1 1 1 G8 domain CHRD PF07452.12 EFC49255.1 - 0.0018 19.2 0.0 0.006 17.5 0.0 2.0 1 0 0 1 1 1 1 CHRD domain Arf PF00025.21 EFC49256.1 - 1.7e-51 174.2 1.0 1.9e-51 174.0 1.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC49256.1 - 1.6e-10 41.3 0.2 2.2e-10 40.8 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC49256.1 - 1.4e-08 34.5 0.2 1.5e-08 34.4 0.2 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 EFC49256.1 - 1e-07 31.5 0.8 1.3e-07 31.3 0.8 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC49256.1 - 1.6e-07 30.9 1.7 1.9e-07 30.7 1.7 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC49256.1 - 1.1e-06 28.7 0.1 1.6e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFC49256.1 - 2.3e-06 27.0 4.8 0.0011 18.2 1.8 2.3 1 1 1 2 2 2 2 G-protein alpha subunit 6PF2K PF01591.18 EFC49256.1 - 0.011 15.1 0.5 0.023 14.0 0.5 1.6 1 1 0 1 1 1 0 6-phosphofructo-2-kinase VWA_3 PF13768.6 EFC49256.1 - 0.055 13.4 0.2 0.079 12.9 0.2 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Exo_endo_phos_2 PF14529.6 EFC49257.1 - 0.0029 17.5 1.1 0.16 11.8 0.1 3.2 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 EFC49257.1 - 0.0029 17.1 0.0 0.0046 16.5 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PARP PF00644.20 EFC49258.1 - 4.6e-26 91.6 3.1 1.8e-24 86.4 3.1 2.0 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 EFC49258.1 - 0.043 13.6 0.2 0.078 12.7 0.2 1.5 2 0 0 2 2 2 0 Exotoxin A catalytic GST_N PF02798.20 EFC49259.1 - 2.2e-19 69.6 0.0 3.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC49259.1 - 1.6e-18 66.9 0.0 2.5e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC49259.1 - 3e-16 59.5 0.0 4.5e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC49259.1 - 1.7e-14 53.8 0.0 2.1e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC49259.1 - 1.1e-05 25.6 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC49259.1 - 0.0019 18.2 0.0 0.0033 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Aldo_ket_red PF00248.21 EFC49260.1 - 1.4e-67 228.0 0.0 1.6e-67 227.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Peptidase_C1 PF00112.23 EFC49261.1 - 2.3e-51 175.0 6.1 2.9e-51 174.6 6.1 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC49261.1 - 2.2e-06 26.7 0.7 0.034 12.9 0.0 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC49261.1 - 0.00011 22.0 0.1 0.00026 20.8 0.1 1.7 1 0 0 1 1 1 1 Peptidase family C1 propeptide dNK PF01712.19 EFC49262.1 - 3.1e-23 82.7 5.4 4.2e-16 59.4 0.3 2.2 1 1 1 2 2 2 2 Deoxynucleoside kinase G-alpha PF00503.20 EFC49262.1 - 0.0014 17.9 2.3 0.0036 16.5 1.9 2.0 1 1 1 2 2 2 1 G-protein alpha subunit DUF2202 PF09968.9 EFC49262.1 - 0.015 15.2 0.2 0.41 10.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein domain (DUF2202) AAA_22 PF13401.6 EFC49262.1 - 0.025 14.9 0.0 0.068 13.5 0.0 1.8 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 EFC49262.1 - 0.075 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 EFC49262.1 - 0.14 12.5 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF2937 PF11157.8 EFC49263.1 - 0.004 16.9 0.0 0.0076 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2937) Receptor_2B4 PF11465.8 EFC49263.1 - 0.1 12.8 3.2 0.1 12.8 0.9 2.1 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Peptidase_M1 PF01433.20 EFC49264.1 - 2.4e-77 259.4 4.6 3.9e-77 258.7 4.6 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 EFC49264.1 - 1.3e-75 254.9 0.0 6.6e-75 252.6 0.0 2.1 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 EFC49264.1 - 7.8e-45 153.4 0.2 1.7e-44 152.2 0.2 1.6 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Noc2 PF03715.13 EFC49264.1 - 0.022 14.0 1.3 2.8 7.1 0.0 2.3 2 0 0 2 2 2 0 Noc2p family Peptidase_S28 PF05577.12 EFC49265.1 - 2.1e-117 392.6 4.5 2.4e-117 392.4 4.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 EFC49265.1 - 0.0001 21.9 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 EFC49265.1 - 0.023 14.0 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 START PF01852.19 EFC49266.1 - 0.00068 19.1 0.0 0.0015 17.9 0.0 1.4 1 1 1 2 2 2 1 START domain SPRY PF00622.28 EFC49267.1 - 0.0016 18.6 0.2 0.21 11.7 0.0 2.4 2 0 0 2 2 2 2 SPRY domain Mrx7 PF10906.8 EFC49267.1 - 0.0092 16.2 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 MIOREX complex component 7 F-box PF00646.33 EFC49267.1 - 0.022 14.6 0.1 0.094 12.6 0.2 2.0 2 0 0 2 2 2 0 F-box domain SidC_N PF18219.1 EFC49267.1 - 0.023 13.7 0.1 0.038 13.0 0.1 1.3 1 0 0 1 1 1 0 SidC N-terminal domain F-box-like PF12937.7 EFC49267.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like SecM PF06558.12 EFC49268.1 - 0.3 11.2 2.1 14 5.8 0.0 3.2 3 0 0 3 3 3 0 Secretion monitor precursor protein (SecM) ADH_N PF08240.12 EFC49269.1 - 1.8e-11 43.9 0.5 1.9e-10 40.6 0.0 2.6 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 EFC49269.1 - 1.6e-10 42.1 0.0 5.3e-10 40.5 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 EFC49269.1 - 1.8e-07 31.2 0.2 4e-07 30.1 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 EFC49269.1 - 8.7e-06 25.6 0.0 1.9e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Epsilon_antitox PF08998.11 EFC49269.1 - 0.1 12.9 0.3 0.88 9.9 0.2 2.2 2 0 0 2 2 2 0 Bacterial epsilon antitoxin YjeF_N PF03853.15 EFC49269.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Eno-Rase_NADH_b PF12242.8 EFC49269.1 - 0.14 12.0 0.1 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase LRR_6 PF13516.6 EFC49271.1 - 1e-52 171.7 5.6 9.7e-05 22.1 0.0 11.5 11 0 0 11 11 11 11 Leucine Rich repeat LRR_8 PF13855.6 EFC49271.1 - 4.5e-30 103.2 16.0 5.8e-07 29.2 0.0 5.9 2 1 6 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC49271.1 - 5.4e-27 93.4 4.8 0.00013 22.2 0.0 7.0 6 1 0 6 6 6 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC49271.1 - 2.2e-13 48.8 0.0 29 5.7 0.0 10.8 12 0 0 12 12 12 0 Leucine Rich Repeat Mannitol_dh PF01232.23 EFC49271.1 - 0.00023 21.4 1.6 0.67 10.1 0.1 3.1 2 1 1 3 3 3 2 Mannitol dehydrogenase Rossmann domain Apo-VLDL-II PF05418.11 EFC49271.1 - 0.0062 17.1 0.4 8 7.1 0.0 4.6 3 1 1 5 5 5 1 Apovitellenin I (Apo-VLDL-II) ApoB100_C PF12491.8 EFC49271.1 - 2.1 8.4 19.7 18 5.4 0.5 8.1 4 3 4 9 9 9 0 Apolipoprotein B100 C terminal G-alpha PF00503.20 EFC49272.1 - 2.7e-63 214.3 10.5 3.5e-63 213.9 10.5 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC49272.1 - 6.2e-07 29.0 1.6 0.0028 17.1 0.2 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC49272.1 - 2.3e-05 23.9 0.7 0.00068 19.1 0.2 2.4 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC49272.1 - 0.051 13.8 2.3 0.61 10.3 0.2 2.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase LRR_6 PF13516.6 EFC49273.1 - 2e-63 205.1 9.2 2.3e-05 24.1 0.0 12.3 12 0 0 12 12 12 12 Leucine Rich repeat LRR_4 PF12799.7 EFC49273.1 - 2.7e-39 132.5 32.2 0.00014 22.2 0.1 7.5 1 1 11 12 12 12 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49273.1 - 5.6e-38 128.5 23.8 5.3e-07 29.3 0.1 5.9 2 1 6 8 8 8 7 Leucine rich repeat LRR_1 PF00560.33 EFC49273.1 - 3.8e-20 69.3 0.1 11 7.1 0.0 12.5 13 0 0 13 13 13 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC49273.1 - 2.9e-08 33.4 1.9 0.067 12.7 0.1 3.6 1 1 2 3 3 3 3 Leucine-rich repeat DUF4347 PF14252.6 EFC49273.1 - 1.4e-06 28.3 4.1 80 3.0 0.0 8.4 1 1 8 10 10 10 0 Domain of unknown function (DUF4347) DUF5490 PF17593.2 EFC49273.1 - 0.00064 19.7 6.0 56 3.8 0.0 7.6 6 4 3 10 10 10 0 Family of unknown function (DUF5490) Brucella_OMP2 PF05244.11 EFC49273.1 - 0.0012 18.3 2.1 1.9 7.8 0.1 3.7 1 1 3 4 4 4 2 Brucella outer membrane protein 2 HydF_dimer PF18128.1 EFC49273.1 - 0.0014 18.7 6.8 0.82 9.8 0.2 4.4 2 1 3 5 5 5 2 Hydrogen maturase F dimerization domain Radical_SAM_C PF16199.5 EFC49273.1 - 0.0089 16.0 0.0 48 4.1 0.0 5.1 2 1 0 2 2 2 0 Radical_SAM C-terminal domain Dynein_heavy PF03028.15 EFC49273.1 - 0.067 13.3 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain DUF424 PF04242.13 EFC49273.1 - 0.22 11.8 4.3 7.8 6.8 0.0 4.5 3 1 3 6 6 6 0 Protein of unknown function (DUF424) MMR_HSR1 PF01926.23 EFC49274.1 - 0.028 14.5 0.0 0.12 12.5 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase WH2 PF02205.20 EFC49275.1 - 4.1e-07 29.6 2.0 7.4e-07 28.8 0.1 2.5 2 0 0 2 2 2 1 WH2 motif PhyH PF05721.13 EFC49277.1 - 4.1e-05 23.9 0.0 0.065 13.5 0.0 2.4 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 EFC49277.1 - 0.017 13.9 0.0 0.37 9.5 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1479) TauD PF02668.16 EFC49277.1 - 0.051 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family Dicty_REP PF05086.12 EFC49277.1 - 7.6 4.4 10.6 11 3.8 10.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TPR_2 PF07719.17 EFC49278.1 - 4.9e-25 85.6 16.9 0.00048 20.0 0.0 8.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49278.1 - 2.8e-19 68.1 25.9 4.8e-05 23.0 0.1 7.6 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49278.1 - 2.4e-12 46.9 9.8 0.0028 17.9 0.2 5.5 4 2 1 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49278.1 - 8.5e-11 41.2 20.9 0.0035 17.4 0.1 7.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49278.1 - 9.1e-10 38.1 14.0 0.021 14.5 0.0 6.0 5 1 1 6 6 6 3 TPR repeat TPR_19 PF14559.6 EFC49278.1 - 1.2e-09 38.6 10.2 1.1e-06 29.0 4.2 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC49278.1 - 2.9e-07 30.7 0.5 2.1 9.4 0.4 5.7 5 2 3 8 8 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49278.1 - 3.6e-07 30.7 2.2 0.025 15.2 0.0 4.6 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC49278.1 - 9.6e-07 28.4 9.0 1.7 8.8 0.0 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49278.1 - 1.3e-06 28.4 9.6 0.091 13.2 0.0 7.0 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49278.1 - 8.7e-06 26.1 14.6 1.2 9.9 0.1 7.3 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC49278.1 - 0.00031 20.8 0.0 0.023 14.8 0.0 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.14 EFC49278.1 - 0.03 13.7 3.3 0.03 13.7 0.3 2.2 2 0 0 2 2 2 0 Coatomer epsilon subunit Ubiq-assoc PF09145.10 EFC49278.1 - 0.034 14.1 3.3 0.49 10.4 0.0 3.7 3 1 1 4 4 4 0 Ubiquitin-associated MIT PF04212.18 EFC49278.1 - 0.034 14.2 8.7 12 6.0 0.1 5.7 5 2 2 7 7 6 0 MIT (microtubule interacting and transport) domain Helo_like_N PF17111.5 EFC49278.1 - 0.19 11.1 6.6 0.089 12.1 1.0 2.6 2 1 1 3 3 3 0 Fungal N-terminal domain of STAND proteins ANAPC3 PF12895.7 EFC49278.1 - 6.2 7.1 19.6 2.1 8.6 0.9 5.1 4 2 3 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 SBP_bac_3 PF00497.20 EFC49279.1 - 4e-12 46.1 0.0 9.2e-12 44.9 0.0 1.5 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 F-box-like PF12937.7 EFC49280.1 - 3.1e-09 36.6 0.3 5.8e-09 35.7 0.3 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC49280.1 - 0.002 17.9 0.3 0.0045 16.8 0.3 1.5 1 0 0 1 1 1 1 F-box domain PALB2_WD40 PF16756.5 EFC49280.1 - 0.19 10.6 0.0 12 4.7 0.0 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Guanylate_cyc PF00211.20 EFC49281.1 - 1.1e-27 96.9 0.0 2.4e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain dCache_1 PF02743.18 EFC49281.1 - 1.9e-10 41.0 0.6 3.7e-10 40.0 0.6 1.4 1 0 0 1 1 1 1 Cache domain DUF515 PF04415.12 EFC49281.1 - 0.019 13.4 0.4 0.04 12.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF1198 PF06711.11 EFC49281.1 - 0.73 9.9 3.8 0.27 11.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) Sigma_reg_N PF13800.6 EFC49281.1 - 2.5 8.5 9.7 0.26 11.6 2.0 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal HemY_N PF07219.13 EFC49281.1 - 5 7.4 8.4 4.3 7.6 1.0 2.3 2 0 0 2 2 2 0 HemY protein N-terminus Ctr PF04145.15 EFC49282.1 - 7e-15 55.9 22.3 1e-08 35.9 10.2 2.5 2 1 1 3 3 3 2 Ctr copper transporter family DUF1043 PF06295.12 EFC49282.1 - 0.17 11.9 1.1 1 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) ABC2_membrane_3 PF12698.7 EFC49282.1 - 0.56 9.3 12.1 0.76 8.8 12.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Arf PF00025.21 EFC49283.1 - 3.2e-34 117.9 0.0 3.6e-34 117.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC49283.1 - 3.5e-07 30.5 0.0 5.3e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC49283.1 - 1.5e-05 24.7 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC49283.1 - 1.5e-05 24.3 0.3 0.073 12.2 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC49283.1 - 0.0017 17.7 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC49283.1 - 0.0028 17.7 0.0 0.0045 17.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC49283.1 - 0.045 13.2 0.0 0.083 12.3 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RGS PF00615.19 EFC49285.1 - 2.4e-09 37.5 3.2 2.4e-09 37.5 3.2 3.6 4 0 0 4 4 4 1 Regulator of G protein signaling domain GPS PF01825.21 EFC49285.1 - 0.00011 22.6 3.6 0.00011 22.6 3.6 2.3 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC49285.1 - 0.0036 17.6 15.7 0.15 12.5 5.0 2.6 2 0 0 2 2 2 2 EGF-like domain SBD PF17882.1 EFC49285.1 - 0.1 12.4 0.6 9.9 6.0 0.0 2.9 3 0 0 3 3 3 0 OAA-family lectin sugar binding domain Fib_alpha PF08702.10 EFC49285.1 - 2.1 8.5 8.8 2 8.6 4.0 2.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3808 PF10300.9 EFC49286.1 - 4.8e-37 127.8 3.1 4.8e-37 127.8 3.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 EFC49286.1 - 7.7e-06 25.6 0.6 0.82 9.9 0.0 5.2 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49286.1 - 4.4e-05 23.4 9.4 0.078 13.2 0.0 5.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49286.1 - 0.0011 19.2 0.1 2.6 8.4 0.0 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49286.1 - 0.0016 18.1 0.0 13 5.8 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49286.1 - 0.0051 16.5 0.0 0.47 10.2 0.0 2.9 2 0 0 2 2 2 1 TPR repeat ANAPC3 PF12895.7 EFC49286.1 - 0.012 15.8 0.0 0.075 13.3 0.0 2.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Orthopox_B11R PF07033.11 EFC49286.1 - 2.5 8.0 4.7 1.6 8.6 1.7 2.2 2 0 0 2 2 2 0 Orthopoxvirus B11R protein Peptidase_C1 PF00112.23 EFC49287.1 - 9.3e-46 156.7 7.6 1.1e-45 156.4 7.6 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC49287.1 - 0.052 12.3 0.5 0.052 12.3 0.5 1.5 2 0 0 2 2 2 0 Peptidase C1-like family Pkinase PF00069.25 EFC49288.1 - 2.3e-53 181.3 0.1 2.9e-53 180.9 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49288.1 - 1.7e-31 109.5 0.0 2.2e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC49288.1 - 5.4e-05 22.1 0.1 8.9e-05 21.4 0.1 1.3 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC49288.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ILEI PF15711.5 EFC49288.1 - 0.1 13.1 0.2 0.27 11.7 0.2 1.8 1 0 0 1 1 1 0 Interleukin-like EMT inducer AhpC-TSA PF00578.21 EFC49289.1 - 2.9e-05 24.0 0.2 0.00092 19.1 0.0 2.2 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 EFC49289.1 - 0.00015 22.0 0.5 0.0012 19.1 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin-like GSHPx PF00255.19 EFC49289.1 - 0.00027 20.5 0.1 0.00048 19.7 0.1 1.5 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 EFC49289.1 - 0.0094 15.7 0.1 0.13 12.0 0.0 2.1 2 0 0 2 2 2 1 Redoxin Trns_repr_metal PF02583.17 EFC49289.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.7 2 0 0 2 2 2 0 Metal-sensitive transcriptional repressor HAD_2 PF13419.6 EFC49290.1 - 0.96 9.5 4.0 5.4 7.1 0.1 2.8 2 1 1 3 3 3 0 Haloacid dehalogenase-like hydrolase CNOT11 PF10155.9 EFC49290.1 - 5.2 7.2 7.3 2.3e+02 1.9 5.2 3.1 2 1 0 2 2 2 0 CCR4-NOT transcription complex subunit 11 PQ-loop PF04193.14 EFC49291.1 - 4e-29 100.2 13.1 1.6e-14 53.4 4.8 2.8 2 0 0 2 2 2 2 PQ loop repeat Guanylate_cyc PF00211.20 EFC49292.1 - 5.9e-48 162.9 0.0 1.1e-47 162.0 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC49292.1 - 4.2e-17 62.3 0.1 1.4e-16 60.7 0.1 2.0 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC49292.1 - 8.5e-08 32.2 0.0 2.7e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 EFC49292.1 - 0.00055 20.2 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC49292.1 - 0.00058 19.8 0.0 0.0019 18.2 0.0 1.9 1 0 0 1 1 1 1 PAS domain 2-oxoacid_dh PF00198.23 EFC49293.1 - 1.9e-83 279.5 0.3 2.4e-83 279.1 0.3 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 EFC49293.1 - 3.4e-18 65.3 2.8 5.9e-18 64.5 2.8 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF1525 PF07511.11 EFC49293.1 - 0.0069 16.5 0.1 0.017 15.3 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1525) Hamartin PF04388.12 EFC49293.1 - 0.018 13.8 1.8 0.021 13.5 1.8 1.1 1 0 0 1 1 1 0 Hamartin protein NAM-associated PF14303.6 EFC49293.1 - 0.12 13.1 5.5 0.19 12.4 5.5 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain ORC6 PF05460.13 EFC49293.1 - 1.1 8.5 7.0 1.4 8.1 7.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Mucin PF01456.17 EFC49293.1 - 3.5 7.6 25.9 5.8 6.9 25.9 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 EFC49293.1 - 4.3 5.4 15.6 6.5 4.8 15.6 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Med3 PF11593.8 EFC49293.1 - 4.9 6.2 18.3 7.6 5.6 18.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal p450 PF00067.22 EFC49294.1 - 4.5e-64 216.9 0.4 1.3e-63 215.4 0.4 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF1160 PF06648.11 EFC49294.1 - 0.12 12.4 0.2 3 7.8 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) Guanylate_cyc PF00211.20 EFC49295.1 - 1.8e-48 164.6 0.1 4.2e-48 163.4 0.1 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC49295.1 - 1.4e-13 51.0 0.1 4.2e-13 49.4 0.1 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC49295.1 - 0.0097 16.2 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 EFC49295.1 - 0.012 15.7 0.0 0.04 13.9 0.0 2.0 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC49295.1 - 0.076 12.4 2.8 0.29 10.5 0.3 2.5 2 0 0 2 2 2 0 Heme NO binding associated DUF5527 PF17665.1 EFC49295.1 - 0.27 10.8 1.2 1.1 8.8 1.2 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5527) DEAD PF00270.29 EFC49297.1 - 6.5e-17 61.8 0.0 2e-16 60.3 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC49297.1 - 1.3e-14 54.6 0.0 5.7e-14 52.5 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC49297.1 - 6.3e-09 36.2 0.0 4.5e-08 33.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TniB PF05621.11 EFC49297.1 - 0.085 12.3 0.1 13 5.2 0.0 3.1 3 0 0 3 3 3 0 Bacterial TniB protein Helicase_IV_N PF12462.8 EFC49297.1 - 0.42 10.5 4.4 1.4 8.8 0.1 3.0 3 0 0 3 3 3 0 DNA helicase IV / RNA helicase N terminal LRR_4 PF12799.7 EFC49298.1 - 0.00069 20.0 9.3 1.6 9.3 0.1 5.5 3 2 2 5 5 5 2 Leucine Rich repeats (2 copies) Ras PF00071.22 EFC49299.1 - 4.8e-29 101.0 0.0 5.6e-29 100.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC49299.1 - 3e-06 26.8 0.1 3.4e-06 26.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC49299.1 - 3e-05 24.2 0.0 5.5e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EFC49299.1 - 0.0013 18.3 0.0 0.0015 18.0 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC49299.1 - 0.015 15.2 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase G-alpha PF00503.20 EFC49299.1 - 0.017 14.3 0.1 0.018 14.2 0.1 1.1 1 0 0 1 1 1 0 G-protein alpha subunit GTP_EFTU PF00009.27 EFC49299.1 - 0.04 13.5 0.0 0.064 12.8 0.0 1.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF2981 PF11200.8 EFC49300.1 - 0.13 12.0 0.7 0.22 11.2 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF3270 PF11674.8 EFC49300.1 - 1.6 9.0 9.1 4.2 7.6 0.5 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3270) MpPF26 PF07666.11 EFC49300.1 - 7.6 6.7 15.0 0.33 11.1 5.8 2.4 1 1 1 2 2 2 0 M penetrans paralogue family 26 Exo_endo_phos PF03372.23 EFC49301.1 - 2.5e-06 27.2 0.0 4.6e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 EFC49301.1 - 0.011 15.5 0.0 0.13 12.1 0.0 2.3 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase ZoocinA_TRD PF16775.5 EFC49301.1 - 0.058 13.6 0.1 0.38 10.9 0.0 2.1 2 0 0 2 2 2 0 Target recognition domain of lytic exoenzyme DUF3873 PF12989.7 EFC49301.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) ERG2_Sigma1R PF04622.12 EFC49302.1 - 3.6e-46 157.2 3.4 1.5e-42 145.3 1.0 2.0 1 1 1 2 2 2 2 ERG2 and Sigma1 receptor like protein Metallophos PF00149.28 EFC49303.1 - 2.4e-12 47.8 1.8 3.8e-12 47.1 1.4 1.6 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC49303.1 - 2e-10 41.1 0.8 1.4e-06 28.6 0.0 2.1 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain His_Phos_1 PF00300.22 EFC49303.1 - 0.056 13.1 0.0 0.091 12.4 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) NIF PF03031.18 EFC49303.1 - 0.2 11.4 3.1 0.61 9.8 2.3 2.2 1 1 1 2 2 2 0 NLI interacting factor-like phosphatase DUF4116 PF13475.6 EFC49304.1 - 4e-42 141.7 22.4 5.8e-11 42.0 0.0 8.7 5 3 4 9 9 9 9 Domain of unknown function (DUF4116) SPRY PF00622.28 EFC49305.1 - 2.3e-07 31.0 0.4 5e-07 29.8 0.4 1.6 1 0 0 1 1 1 1 SPRY domain PQ-loop PF04193.14 EFC49306.1 - 9.3e-32 108.6 23.1 4.8e-18 64.7 4.2 3.0 3 0 0 3 3 3 2 PQ loop repeat Cytochrom_C_asm PF01578.20 EFC49306.1 - 0.0049 16.7 14.5 0.54 10.0 13.0 3.2 2 1 0 2 2 2 1 Cytochrome C assembly protein MtN3_slv PF03083.16 EFC49306.1 - 0.049 13.7 1.3 0.049 13.7 1.3 3.0 3 1 1 4 4 4 0 Sugar efflux transporter for intercellular exchange UPF0016 PF01169.19 EFC49306.1 - 0.19 12.1 4.1 0.61 10.5 4.1 1.8 1 0 0 1 1 1 0 Uncharacterized protein family UPF0016 AAA_7 PF12775.7 EFC49307.1 - 6.3e-05 22.6 1.0 0.014 14.9 0.0 3.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_5 PF07728.14 EFC49307.1 - 0.0019 18.2 0.0 0.035 14.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 EFC49307.1 - 0.019 15.5 0.0 0.16 12.5 0.0 2.8 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC49307.1 - 0.025 14.9 0.1 0.9 9.8 0.0 3.8 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EFC49307.1 - 0.039 13.9 0.0 0.2 11.5 0.0 2.3 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 EFC49307.1 - 0.055 13.9 0.1 0.79 10.1 0.0 3.1 2 0 0 2 2 2 0 RNA helicase Enkurin PF13864.6 EFC49307.1 - 2 8.9 9.3 5.3 7.5 0.4 3.9 3 0 0 3 3 3 0 Calmodulin-binding Ribonuc_L-PSP PF01042.21 EFC49308.1 - 7.3e-36 122.8 0.0 8.9e-36 122.6 0.0 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP LRR_4 PF12799.7 EFC49309.1 - 0.00065 20.0 1.1 0.00065 20.0 1.1 9.1 5 2 5 10 10 10 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC49309.1 - 0.19 12.4 29.3 11 7.0 0.3 9.0 7 3 2 9 9 9 0 Leucine Rich Repeat YabA PF06156.13 EFC49310.1 - 0.087 13.5 1.9 0.18 12.4 0.4 2.1 2 0 0 2 2 2 0 Initiation control protein YabA RGS PF00615.19 EFC49311.1 - 0.0035 17.6 4.2 0.011 16.0 4.2 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain MARVEL PF01284.23 EFC49313.1 - 0.011 15.7 2.1 0.011 15.7 2.1 2.0 1 1 1 2 2 2 0 Membrane-associating domain Orf78 PF06024.12 EFC49313.1 - 0.05 13.9 0.1 0.13 12.5 0.1 1.7 2 0 0 2 2 2 0 Orf78 (ac78) CrgA PF06781.12 EFC49313.1 - 0.14 12.3 3.4 9.7 6.3 0.2 3.2 1 1 2 3 3 3 0 Cell division protein CrgA DUF4834 PF16118.5 EFC49313.1 - 0.52 11.3 5.3 0.85 10.6 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) Glyco_hydro_99 PF16317.5 EFC49314.1 - 8.3e-119 396.7 14.8 1.1e-118 396.4 14.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 99 TLD PF07534.16 EFC49315.1 - 0.0042 17.3 0.4 0.014 15.6 0.4 1.9 1 0 0 1 1 1 1 TLD DUF1473 PF07341.11 EFC49315.1 - 0.2 11.4 1.9 0.22 11.3 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1473) GREB1 PF15782.5 EFC49315.1 - 5.3 4.0 14.0 6.7 3.7 14.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RCC1_2 PF13540.6 EFC49316.1 - 7.7e-07 28.7 0.5 0.008 15.9 0.1 4.5 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC49316.1 - 0.0027 18.3 0.0 1.2 9.8 0.0 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Glyco_transf_4 PF13439.6 EFC49318.1 - 0.011 15.8 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Ras PF00071.22 EFC49319.1 - 8.4e-46 155.5 0.0 1e-45 155.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49319.1 - 1.2e-22 80.4 0.0 1.9e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49319.1 - 5.8e-05 22.6 0.0 7.8e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Ammonium_transp PF00909.21 EFC49320.1 - 2.7e-101 339.2 27.6 3.1e-101 339.0 27.6 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF4145 PF13643.6 EFC49320.1 - 0.025 14.7 0.3 0.058 13.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4145) DUF3450 PF11932.8 EFC49321.1 - 0.017 14.4 8.3 0.48 9.7 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) bZIP_1 PF00170.21 EFC49321.1 - 0.034 14.3 8.8 0.13 12.4 0.6 3.3 2 1 1 3 3 3 0 bZIP transcription factor GIT_CC PF16559.5 EFC49321.1 - 0.037 13.9 0.7 0.037 13.9 0.7 3.2 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2796 PF10986.8 EFC49321.1 - 0.074 13.0 6.1 0.59 10.1 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) FlaC_arch PF05377.11 EFC49321.1 - 0.089 13.2 1.1 0.089 13.2 1.1 2.8 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Hexokinase_2 PF03727.16 EFC49321.1 - 0.1 12.0 0.7 0.18 11.2 0.7 1.3 1 0 0 1 1 1 0 Hexokinase Carbpep_Y_N PF05388.11 EFC49321.1 - 0.27 11.8 4.8 0.16 12.5 2.3 1.8 1 1 0 1 1 1 0 Carboxypeptidase Y pro-peptide XhlA PF10779.9 EFC49321.1 - 0.88 9.8 5.6 16 5.8 1.9 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Salp15 PF12115.8 EFC49321.1 - 5.5 7.5 9.1 5.3 7.5 2.8 2.5 2 1 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation DUF2362 PF10154.9 EFC49322.1 - 0.0036 16.3 3.6 0.0039 16.2 3.6 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) DUF2229 PF09989.9 EFC49322.1 - 0.055 13.1 0.6 0.063 12.9 0.6 1.1 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) LRR_4 PF12799.7 EFC49323.1 - 5.9e-25 86.9 29.0 9.1e-07 29.1 1.2 8.5 2 2 7 10 10 10 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49323.1 - 7.8e-25 86.4 22.9 1.5e-08 34.3 2.4 6.5 4 1 4 8 8 8 8 Leucine rich repeat LRR_6 PF13516.6 EFC49323.1 - 5.1e-23 79.1 26.9 2.1e-05 24.2 0.3 11.2 11 1 0 11 11 11 7 Leucine Rich repeat LRR_1 PF00560.33 EFC49323.1 - 7.1e-07 28.9 18.2 2 9.3 0.1 10.9 12 1 0 12 12 12 1 Leucine Rich Repeat LRR_9 PF14580.6 EFC49323.1 - 7.2e-06 25.6 8.2 0.25 10.8 0.4 3.6 1 1 1 3 3 3 3 Leucine-rich repeat Beta_helix PF13229.6 EFC49323.1 - 0.0013 18.6 4.3 0.0031 17.4 4.3 1.7 1 0 0 1 1 1 1 Right handed beta helix region F-box-like PF12937.7 EFC49323.1 - 0.04 13.8 0.3 0.095 12.6 0.3 1.6 1 0 0 1 1 1 0 F-box-like Dev_Cell_Death PF10539.9 EFC49323.1 - 0.088 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Development and cell death domain RGS PF00615.19 EFC49324.1 - 0.0023 18.2 1.3 0.0048 17.1 1.3 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain PB1-F2 PF11986.8 EFC49324.1 - 0.21 11.8 0.4 6 7.2 0.1 2.4 2 0 0 2 2 2 0 Influenza A Proapoptotic protein DUF3349 PF11829.8 EFC49325.1 - 0.011 16.5 1.7 0.5 11.2 0.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) BORCS7 PF16088.5 EFC49325.1 - 9.6 6.5 13.9 0.7 10.2 6.9 2.8 2 2 1 3 3 3 0 BLOC-1-related complex sub-unit 7 H_lectin PF09458.10 EFC49326.1 - 0.00053 20.1 9.2 0.045 13.9 0.8 4.5 4 0 0 4 4 4 3 H-type lectin domain DUF1180 PF06679.12 EFC49327.1 - 0.4 11.1 5.0 0.5 10.8 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) RCC1 PF00415.18 EFC49328.1 - 4.4e-19 68.8 1.5 0.0004 21.0 0.0 5.0 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC49328.1 - 6.2e-06 26.5 25.0 0.00015 22.0 8.4 2.8 2 0 0 2 2 2 2 EGF-like domain RCC1_2 PF13540.6 EFC49328.1 - 0.00013 21.6 10.4 2.8 7.9 0.1 6.2 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat EGF PF00008.27 EFC49328.1 - 0.00082 19.6 3.9 0.00082 19.6 3.9 2.8 2 0 0 2 2 2 1 EGF-like domain hEGF PF12661.7 EFC49328.1 - 0.015 15.9 6.5 0.015 15.9 6.5 3.1 2 0 0 2 2 2 0 Human growth factor-like EGF DAO_C PF16901.5 EFC49329.1 - 3.3e-12 46.4 0.0 7.3e-12 45.3 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase DAO PF01266.24 EFC49329.1 - 9.3e-08 32.0 0.0 5.9e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase BTB PF00651.31 EFC49330.1 - 2.1e-25 89.1 1.0 2.1e-25 89.1 1.0 2.4 2 1 1 3 3 3 1 BTB/POZ domain GAF PF01590.26 EFC49330.1 - 1.6e-13 51.4 0.0 5e-13 49.8 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 EFC49330.1 - 2.6e-08 34.3 0.0 4.3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 EFC49330.1 - 0.00012 22.4 0.0 0.00026 21.4 0.0 1.6 1 0 0 1 1 1 1 GAF domain zf-CCHC PF00098.23 EFC49331.1 - 0.00025 21.0 0.6 0.0004 20.3 0.6 1.3 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 EFC49331.1 - 0.00082 19.1 2.8 0.0013 18.5 2.8 1.3 1 0 0 1 1 1 1 Zinc knuckle Phage_integrase PF00589.22 EFC49331.1 - 0.037 13.8 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Phage integrase family FAM176 PF14851.6 EFC49331.1 - 8.3 6.1 8.2 20 4.8 8.2 1.6 1 0 0 1 1 1 0 FAM176 family Prenylcys_lyase PF07156.14 EFC49332.1 - 4e-54 184.1 0.9 8.6e-54 183.0 0.9 1.5 1 1 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 EFC49332.1 - 1.7e-13 50.7 0.0 2.7e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 EFC49332.1 - 0.00014 22.0 0.1 0.00067 19.8 0.1 2.0 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 EFC49332.1 - 0.035 13.7 0.0 0.079 12.5 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 EFC49332.1 - 0.22 10.7 0.0 5.8 6.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF2706 PF10913.8 EFC49333.1 - 0.07 13.0 3.3 0.17 11.7 3.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2706) DsbD PF02683.15 EFC49333.1 - 0.42 10.5 6.3 0.83 9.5 0.8 2.4 2 0 0 2 2 2 0 Cytochrome C biogenesis protein transmembrane region EI24 PF07264.11 EFC49333.1 - 3.3 7.9 7.9 11 6.2 1.0 2.2 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Acetyltransf_7 PF13508.7 EFC49334.1 - 2.4e-07 31.1 0.0 3.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC49334.1 - 4e-06 27.1 0.0 2.2e-05 24.7 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC49334.1 - 3.8e-05 23.6 0.3 0.0034 17.3 0.1 3.0 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 EFC49334.1 - 0.00081 18.9 0.2 0.0009 18.8 0.2 1.1 1 0 0 1 1 1 1 Putative acetyl-transferase FR47 PF08445.10 EFC49334.1 - 0.0031 17.4 0.0 0.021 14.8 0.0 2.1 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_5 PF13444.6 EFC49334.1 - 0.0075 17.0 0.0 0.012 16.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain COesterase PF00135.28 EFC49335.1 - 7.4e-89 298.9 0.0 3e-88 297.0 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 EFC49335.1 - 2.1e-05 24.5 0.0 5.1e-05 23.2 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Cutinase PF01083.22 EFC49335.1 - 0.095 12.7 0.0 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 Cutinase Leu_zip PF15294.6 EFC49337.1 - 2.2e-36 125.8 35.5 1.7e-35 122.9 35.5 1.9 1 1 0 1 1 1 1 Leucine zipper GAS PF13851.6 EFC49337.1 - 0.0039 16.6 33.9 0.06 12.7 33.9 2.4 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding Filament PF00038.21 EFC49337.1 - 0.011 15.4 29.0 0.05 13.2 15.9 2.3 1 1 1 2 2 2 0 Intermediate filament protein COG2 PF06148.11 EFC49337.1 - 0.019 15.0 18.5 0.24 11.5 2.2 3.2 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 EFC49337.1 - 0.026 14.6 5.0 0.026 14.6 5.0 3.8 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) HBM PF16591.5 EFC49337.1 - 0.029 13.8 19.9 0.2 11.0 9.2 2.9 1 1 2 3 3 3 0 Helical bimodular sensor domain Hemerythrin PF01814.23 EFC49337.1 - 0.04 14.6 1.0 0.92 10.1 0.0 3.0 2 2 1 3 3 3 0 Hemerythrin HHE cation binding domain TFX_C PF14601.6 EFC49337.1 - 0.097 12.6 2.1 0.36 10.8 0.1 2.5 2 0 0 2 2 2 0 DNA_binding protein, TFX, C-term DUF4407 PF14362.6 EFC49337.1 - 0.11 11.8 22.1 0.08 12.3 11.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF2913 PF11140.8 EFC49337.1 - 0.12 12.1 14.4 1.3 8.7 2.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2913) Fez1 PF06818.15 EFC49337.1 - 0.12 12.8 33.6 0.14 12.6 13.5 2.9 2 1 1 3 3 3 0 Fez1 KAR PF15222.6 EFC49337.1 - 0.21 11.9 4.8 0.41 11.0 2.7 2.4 1 1 1 2 2 2 0 Kidney androgen-regulated ATG16 PF08614.11 EFC49337.1 - 0.23 11.7 31.4 2 8.6 5.8 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF2179 PF10035.9 EFC49337.1 - 0.24 11.2 1.3 1.1 9.1 0.1 2.7 3 0 0 3 3 2 0 Uncharacterized protein conserved in bacteria (DUF2179) PilJ PF13675.6 EFC49337.1 - 0.25 11.4 7.3 9.1 6.4 0.1 2.9 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF3450 PF11932.8 EFC49337.1 - 0.29 10.4 24.5 0.65 9.3 16.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 EFC49337.1 - 0.29 11.3 34.6 0.31 11.2 15.3 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 EFC49337.1 - 0.38 9.6 37.0 0.0082 15.1 24.9 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein Prominin PF05478.11 EFC49337.1 - 0.39 8.6 23.4 0.055 11.4 16.9 2.1 2 0 0 2 2 2 0 Prominin TolA_bind_tri PF16331.5 EFC49337.1 - 0.39 10.8 17.2 0.18 11.9 4.3 3.6 1 1 2 3 3 3 0 TolA binding protein trimerisation FUSC PF04632.12 EFC49337.1 - 0.39 9.2 0.7 0.51 8.8 0.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Prp19 PF08606.11 EFC49337.1 - 0.43 10.6 7.9 1 9.4 0.6 3.6 2 2 1 3 3 3 0 Prp19/Pso4-like EzrA PF06160.12 EFC49337.1 - 0.46 8.6 34.0 2.1 6.4 27.1 3.6 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Lebercilin PF15619.6 EFC49337.1 - 0.49 10.0 33.3 27 4.4 33.3 2.4 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease GvpG PF05120.12 EFC49337.1 - 0.53 10.3 8.6 0.16 12.0 2.7 2.9 2 1 1 3 3 2 0 Gas vesicle protein G DUF4795 PF16043.5 EFC49337.1 - 0.56 9.8 29.7 0.037 13.6 23.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) APG6_N PF17675.1 EFC49337.1 - 0.63 10.6 36.9 0.55 10.8 20.8 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4250 PF14056.6 EFC49337.1 - 0.67 10.0 7.6 0.56 10.2 0.6 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4250) PI3K_P85_iSH2 PF16454.5 EFC49337.1 - 0.73 9.4 25.7 0.051 13.2 8.0 3.5 1 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FlaC_arch PF05377.11 EFC49337.1 - 0.76 10.2 29.7 0.16 12.4 2.3 5.9 4 2 1 6 6 4 0 Flagella accessory protein C (FlaC) IFT57 PF10498.9 EFC49337.1 - 0.83 8.6 31.2 0.087 11.8 25.6 2.2 2 1 0 2 2 2 0 Intra-flagellar transport protein 57 Atg14 PF10186.9 EFC49337.1 - 0.86 8.6 30.0 1.1 8.2 27.3 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 WXG100 PF06013.12 EFC49337.1 - 0.87 9.9 14.7 4.8 7.5 0.3 4.3 3 1 1 4 4 3 0 Proteins of 100 residues with WXG PspA_IM30 PF04012.12 EFC49337.1 - 0.92 9.0 25.4 0.4 10.2 22.3 2.0 2 0 0 2 2 2 0 PspA/IM30 family Exonuc_VII_L PF02601.15 EFC49337.1 - 0.96 9.0 24.1 10 5.6 24.1 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit HAUS-augmin3 PF14932.6 EFC49337.1 - 1.1 8.8 28.6 0.88 9.1 8.8 2.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 ERM PF00769.19 EFC49337.1 - 1.2 8.9 31.0 0.12 12.1 26.4 1.7 2 0 0 2 2 1 0 Ezrin/radixin/moesin family Baculo_PEP_C PF04513.12 EFC49337.1 - 1.3 9.1 20.2 3.4 7.7 0.5 3.2 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DHR10 PF18595.1 EFC49337.1 - 1.7 8.7 29.1 0.99 9.5 2.9 3.3 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DUF4763 PF15960.5 EFC49337.1 - 1.7 7.9 26.0 0.36 10.1 4.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Cnn_1N PF07989.11 EFC49337.1 - 1.8 8.8 27.8 1.7e+02 2.4 18.0 4.7 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 ADIP PF11559.8 EFC49337.1 - 2.2 8.3 39.8 1.8 8.6 5.6 3.2 2 1 1 3 3 2 0 Afadin- and alpha -actinin-Binding MAD PF05557.13 EFC49337.1 - 2.5 6.4 36.0 0.062 11.7 27.6 1.9 2 0 0 2 2 2 0 Mitotic checkpoint protein DUF812 PF05667.11 EFC49337.1 - 3.4 6.4 35.2 7.6 5.3 10.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) KxDL PF10241.9 EFC49337.1 - 4.1 7.7 28.3 0.24 11.7 3.4 4.0 3 2 1 5 5 3 0 Uncharacterized conserved protein TPR_MLP1_2 PF07926.12 EFC49337.1 - 4.2 7.5 35.7 0.27 11.3 16.9 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein SlyX PF04102.12 EFC49337.1 - 4.8 7.9 17.4 2.8 8.6 3.7 4.6 1 1 3 4 4 4 0 SlyX HrpB7 PF09486.10 EFC49337.1 - 4.9 7.5 12.0 11 6.3 3.8 2.7 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) TMF_TATA_bd PF12325.8 EFC49337.1 - 5.7 7.2 34.4 1.7 8.9 18.2 3.4 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF948 PF06103.11 EFC49337.1 - 6 7.2 21.6 4.2 7.7 4.9 4.0 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Imm7 PF15585.6 EFC49337.1 - 6.1 7.1 11.2 0.67 10.2 1.7 3.4 2 1 3 5 5 4 0 Immunity protein 7 Acetyltransf_11 PF13720.6 EFC49337.1 - 7 7.2 8.3 63 4.1 3.8 4.0 2 2 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 STAT_alpha PF01017.20 EFC49337.1 - 7.4 6.4 24.0 0.28 11.1 4.1 2.9 1 1 1 2 2 2 0 STAT protein, all-alpha domain Golgin_A5 PF09787.9 EFC49337.1 - 8.7 5.7 35.3 0.93 8.9 27.8 2.4 1 1 2 3 3 3 0 Golgin subfamily A member 5 RPA_interact_N PF14766.6 EFC49338.1 - 1.5e-10 40.5 0.5 2.5e-10 39.8 0.5 1.4 1 0 0 1 1 1 1 Replication protein A interacting N-terminal RPA_interact_C PF14768.6 EFC49338.1 - 4.7e-05 23.9 3.8 4.7e-05 23.9 3.8 2.1 2 1 0 2 2 2 1 Replication protein A interacting C-terminal DNA_RNApol_7kD PF03604.13 EFC49338.1 - 0.03 14.0 1.5 0.042 13.5 0.2 1.9 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Na_trans_assoc PF06512.13 EFC49338.1 - 0.16 12.2 4.1 0.19 12.0 4.1 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Ank_5 PF13857.6 EFC49339.1 - 1.1e-08 35.1 0.0 2.6e-05 24.4 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 EFC49339.1 - 8.4e-07 29.5 0.0 2.4e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 EFC49339.1 - 0.00067 19.9 0.4 0.49 11.1 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 EFC49339.1 - 0.00081 19.9 0.6 0.087 13.4 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 EFC49339.1 - 0.02 15.3 0.1 0.19 12.2 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat Lactamase_B_2 PF12706.7 EFC49340.1 - 8.2e-15 54.9 0.5 1.8e-14 53.7 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC49340.1 - 3.1e-07 30.4 0.8 2.6e-06 27.4 0.8 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Ras PF00071.22 EFC49341.1 - 3.6e-67 225.0 0.4 4.5e-67 224.7 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49341.1 - 1.6e-34 118.7 0.1 3.3e-34 117.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49341.1 - 6e-14 51.9 0.2 7.9e-14 51.5 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC49341.1 - 3.1e-05 23.9 0.2 0.25 11.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 EFC49341.1 - 0.00017 21.1 0.3 0.00026 20.4 0.3 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC49341.1 - 0.00046 19.8 0.8 0.0012 18.4 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC49341.1 - 0.00052 20.1 0.2 0.0011 19.0 0.1 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 EFC49341.1 - 0.0015 17.8 4.6 0.017 14.3 1.3 2.8 1 1 1 2 2 2 1 G-protein alpha subunit FeoB_N PF02421.18 EFC49341.1 - 0.016 14.7 0.0 1.8 8.1 0.1 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_29 PF13555.6 EFC49341.1 - 0.056 13.2 0.0 0.17 11.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC49341.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 EFC49341.1 - 0.11 12.5 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) LRR_8 PF13855.6 EFC49342.1 - 2.4 8.0 0.0 2.4 8.0 0.0 6.5 7 1 1 8 8 8 0 Leucine rich repeat Peptidase_C1 PF00112.23 EFC49343.1 - 1.1e-69 234.9 3.5 1.4e-69 234.5 3.5 1.1 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 EFC49343.1 - 4.5e-11 43.0 1.0 9.1e-11 42.0 1.0 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 EFC49343.1 - 1.7e-07 30.4 0.3 6.9e-05 21.8 0.1 2.2 2 0 0 2 2 2 2 Peptidase C1-like family DUF4188 PF13826.6 EFC49343.1 - 0.039 14.3 0.9 0.073 13.4 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4188) LRR_6 PF13516.6 EFC49344.1 - 0.059 13.4 0.0 11 6.4 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeat Rhomboid PF01694.22 EFC49345.1 - 1.9e-24 86.4 14.4 1.9e-24 86.4 14.4 1.6 2 0 0 2 2 2 1 Rhomboid family DUF2076 PF09849.9 EFC49345.1 - 0.00029 21.0 6.9 0.083 12.9 2.8 2.1 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2076) DUF2905 PF11146.8 EFC49345.1 - 0.077 13.2 0.8 0.077 13.2 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2905) PI3_PI4_kinase PF00454.27 EFC49347.1 - 1.3e-53 182.4 0.1 3.3e-52 177.8 0.1 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC49347.1 - 7.3e-52 175.5 1.7 1.1e-51 174.8 1.7 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EFC49347.1 - 0.0028 17.0 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) VapB_antitoxin PF09957.9 EFC49347.1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial antitoxin of type II TA system, VapB zf-C2HC_2 PF13913.6 EFC49349.1 - 1.1e-31 108.1 41.7 7.9e-11 41.6 5.0 6.3 6 0 0 6 6 6 5 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 EFC49349.1 - 0.008 16.9 35.4 0.48 11.4 0.4 6.7 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 EFC49349.1 - 0.013 16.2 19.4 0.12 13.0 0.2 5.0 3 1 3 6 6 6 0 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 EFC49349.1 - 0.029 14.8 23.8 0.097 13.2 0.1 6.3 6 1 0 6 6 6 0 Zinc finger, C2H2 type zf_UBZ PF18439.1 EFC49349.1 - 0.029 14.0 5.4 6.2 6.5 0.1 4.3 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger Ndc1_Nup PF09531.10 EFC49349.1 - 0.037 12.7 7.5 0.053 12.2 7.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PyrI_C PF02748.15 EFC49349.1 - 0.049 13.5 13.9 1.2 9.1 0.1 5.0 5 0 0 5 5 5 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain DUF2318 PF10080.9 EFC49349.1 - 0.051 13.7 16.8 3.9 7.6 0.1 5.1 5 0 0 5 5 5 0 Predicted membrane protein (DUF2318) HypA PF01155.19 EFC49349.1 - 1.2 9.2 19.3 11 6.1 0.2 4.9 6 0 0 6 6 6 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_2 PF13465.6 EFC49349.1 - 1.5 9.4 18.6 31 5.2 0.3 5.9 5 0 0 5 5 5 0 Zinc-finger double domain zf-BED PF02892.15 EFC49349.1 - 1.8 8.7 17.7 0.69 10.0 0.4 5.2 5 0 0 5 5 5 0 BED zinc finger zf-C2H2_11 PF16622.5 EFC49349.1 - 2 8.3 13.3 11 5.9 0.2 4.8 4 0 0 4 4 4 0 zinc-finger C2H2-type NinF PF05810.12 EFC49349.1 - 4.1 7.3 7.5 2.7 7.9 0.5 3.4 3 0 0 3 3 3 0 NinF protein Actin_micro PF17003.5 EFC49349.1 - 6.1 5.9 5.7 1.6 7.8 0.4 2.7 2 1 1 3 3 3 0 Putative actin-like family Syja_N PF02383.18 EFC49350.1 - 1.4e-81 274.3 4.6 1.4e-81 274.3 4.6 1.5 2 0 0 2 2 2 1 SacI homology domain DUF613 PF04764.12 EFC49350.1 - 9.6 6.4 12.0 0.31 11.2 0.5 3.6 3 1 0 4 4 4 0 Protein of unknown function (DUF613) LRR_6 PF13516.6 EFC49351.1 - 2e-33 111.5 30.6 6.9e-05 22.6 0.1 11.9 12 0 0 12 12 12 9 Leucine Rich repeat LRR_8 PF13855.6 EFC49351.1 - 1.3e-26 92.2 30.0 5e-07 29.4 0.0 6.2 3 3 5 8 8 8 7 Leucine rich repeat LRR_4 PF12799.7 EFC49351.1 - 2.7e-20 72.1 32.8 0.00082 19.7 2.6 8.6 3 2 8 11 11 11 10 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC49351.1 - 3.1e-09 36.1 13.0 7.5 7.5 0.0 10.9 12 0 0 12 12 12 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC49351.1 - 1.4e-05 24.7 9.5 0.11 12.0 1.9 3.6 1 1 2 4 4 4 3 Leucine-rich repeat Beta_helix PF13229.6 EFC49351.1 - 0.016 15.1 10.2 0.45 10.3 5.0 3.2 2 2 1 3 3 3 0 Right handed beta helix region LVIVD PF08309.11 EFC49351.1 - 0.078 12.3 0.6 0.47 9.8 0.3 2.4 2 0 0 2 2 2 0 LVIVD repeat Cyt-b5 PF00173.28 EFC49352.1 - 1.2e-07 31.8 0.0 3.3e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Rad60-SLD PF11976.8 EFC49352.1 - 0.12 12.2 1.1 0.77 9.6 0.7 2.4 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Peptidase_S8 PF00082.22 EFC49354.1 - 6.7e-40 137.2 5.6 8.8e-39 133.5 5.6 2.1 1 1 0 1 1 1 1 Subtilase family DUF2207 PF09972.9 EFC49354.1 - 0.0071 15.2 0.2 0.014 14.2 0.2 1.4 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4448 PF14610.6 EFC49354.1 - 0.0097 15.7 1.7 0.021 14.6 1.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) RIFIN PF02009.16 EFC49354.1 - 0.018 15.0 4.9 0.048 13.6 4.9 1.7 1 0 0 1 1 1 0 Rifin Glycophorin_A PF01102.18 EFC49354.1 - 0.021 15.1 1.4 0.047 13.9 1.4 1.5 1 0 0 1 1 1 0 Glycophorin A Saf_2TM PF18303.1 EFC49354.1 - 0.099 12.2 1.1 0.26 10.9 1.1 1.6 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain TMEM154 PF15102.6 EFC49354.1 - 0.24 11.3 7.1 0.027 14.4 2.4 1.8 2 0 0 2 2 2 0 TMEM154 protein family ASFV_J13L PF05568.11 EFC49354.1 - 0.34 10.7 3.8 0.69 9.6 3.8 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein ECSCR PF15820.5 EFC49354.1 - 0.46 10.3 3.1 1.4 8.8 3.1 1.7 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Shisa PF13908.6 EFC49354.1 - 0.68 10.2 6.5 0.11 12.7 1.6 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator OAD_gamma PF04277.13 EFC49354.1 - 1.3 9.7 4.2 2.7 8.6 4.2 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Syndecan PF01034.20 EFC49354.1 - 2.5 8.1 5.5 5.3 7.0 5.5 1.5 1 0 0 1 1 1 0 Syndecan domain Baculo_11_kDa PF06143.11 EFC49354.1 - 7.1 6.3 9.1 17 5.1 9.1 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family Peptidase_S8 PF00082.22 EFC49355.1 - 1e-70 238.4 0.9 6.1e-70 235.8 0.3 2.1 2 0 0 2 2 2 1 Subtilase family TPPII PF12580.8 EFC49355.1 - 1.2e-57 194.5 5.0 2.5e-57 193.4 5.0 1.6 1 0 0 1 1 1 1 Tripeptidyl peptidase II F_actin_bind PF08919.10 EFC49355.1 - 1.1 9.3 11.0 0.024 14.7 1.5 2.7 3 0 0 3 3 3 0 F-actin binding eRF1_2 PF03464.15 EFC49356.1 - 1.6e-41 141.8 0.0 2.9e-41 140.9 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 EFC49356.1 - 1.2e-32 112.7 0.0 2.9e-32 111.5 0.0 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 EFC49356.1 - 2.3e-21 76.1 0.1 3.6e-21 75.5 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 EFC49356.1 - 1.1e-07 32.2 0.0 1.7e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 EFC49356.1 - 4.8e-07 30.1 0.0 7.7e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Ribophorin_I PF04597.14 EFC49357.1 - 5.7e-127 424.6 5.5 8.8e-127 423.9 5.5 1.3 1 0 0 1 1 1 1 Ribophorin I Pex24p PF06398.11 EFC49357.1 - 0.00011 21.3 0.2 0.00019 20.5 0.2 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Cnd1 PF12717.7 EFC49357.1 - 0.38 10.8 3.9 0.73 9.8 3.9 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 DUF910 PF06014.11 EFC49357.1 - 0.71 9.9 4.1 11 6.1 0.2 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF910) TACC_C PF05010.14 EFC49358.1 - 0.0022 17.8 2.3 0.0049 16.7 2.3 1.5 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF5530 PF17670.1 EFC49358.1 - 0.01 15.6 1.9 0.01 15.6 1.9 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5530) DFP PF04127.15 EFC49358.1 - 0.021 14.6 0.1 0.053 13.3 0.1 1.6 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein HIP1_clath_bdg PF16515.5 EFC49358.1 - 1.5 9.5 6.5 14 6.3 3.4 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Guanylate_cyc PF00211.20 EFC49359.1 - 1.2e-05 25.0 0.3 2.9e-05 23.8 0.3 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3139 PF11337.8 EFC49359.1 - 1.6 9.4 6.9 33 5.2 1.5 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3139) SARAF PF06682.12 EFC49360.1 - 0.0025 17.5 0.0 0.0034 17.1 0.0 1.3 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Shisa PF13908.6 EFC49360.1 - 0.0044 17.3 0.7 0.0044 17.3 0.7 2.4 1 1 1 2 2 2 1 Wnt and FGF inhibitory regulator DUF3464 PF11947.8 EFC49360.1 - 0.016 15.0 0.2 0.03 14.1 0.2 1.5 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 SNARE_assoc PF09335.11 EFC49360.1 - 0.022 15.2 0.0 0.037 14.5 0.0 1.3 1 0 0 1 1 1 0 SNARE associated Golgi protein DUF719 PF05334.13 EFC49360.1 - 0.055 13.7 0.1 0.078 13.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF719) ORC6 PF05460.13 EFC49360.1 - 0.065 12.5 5.3 0.078 12.2 5.3 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) RELT PF12606.8 EFC49360.1 - 0.27 10.3 0.1 0.27 10.3 0.1 1.9 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 EphA2_TM PF14575.6 EFC49360.1 - 0.37 11.7 1.4 24 5.9 0.2 2.7 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 EFC49360.1 - 1.4 9.2 3.9 9 6.5 1.4 2.3 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Conotoxin PF02950.17 EFC49360.1 - 8.7 7.4 0.0 8.7 7.4 0.0 2.9 3 1 0 3 3 3 0 Conotoxin Pox_Ag35 PF03286.14 EFC49360.1 - 10 5.9 9.7 18 5.0 9.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein ATE_C PF04377.15 EFC49361.1 - 3.3e-48 163.7 5.6 3.3e-48 163.7 5.6 2.1 2 1 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 EFC49361.1 - 2.4e-22 79.1 4.4 7.6e-22 77.5 4.4 1.9 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Arg_tRNA_synt_N PF03485.16 EFC49361.1 - 0.0011 19.5 0.6 0.0027 18.2 0.6 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain MIF4G_like PF09088.11 EFC49361.1 - 0.029 14.1 0.4 0.062 13.1 0.4 1.5 1 0 0 1 1 1 0 MIF4G like GRIP PF01465.20 EFC49362.1 - 3.1e-14 52.6 0.6 7.5e-14 51.4 0.6 1.7 1 0 0 1 1 1 1 GRIP domain Csm1_N PF18504.1 EFC49362.1 - 0.0094 16.3 9.6 0.0094 16.3 9.6 12.5 7 3 6 14 14 14 3 Csm1 N-terminal domain Endonuc_subdom PF09062.10 EFC49362.1 - 0.059 14.2 0.4 0.22 12.4 0.4 2.0 1 0 0 1 1 1 0 PI-PfuI Endonuclease subdomain IRK PF01007.20 EFC49363.1 - 0.0037 17.1 0.3 0.0065 16.3 0.3 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain DUF3592 PF12158.8 EFC49363.1 - 0.012 15.7 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3592) MCR_D PF02505.14 EFC49363.1 - 0.16 11.8 0.0 0.4 10.5 0.0 1.6 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein D CLP1_P PF16575.5 EFC49364.1 - 2.6e-61 206.7 0.6 4.3e-61 206.0 0.2 1.5 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 EFC49364.1 - 4e-26 91.7 0.0 6.6e-26 91.0 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 EFC49364.1 - 1.5e-25 89.3 0.0 2.6e-25 88.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_10 PF12846.7 EFC49364.1 - 0.0002 20.4 0.0 0.00035 19.6 0.0 1.3 1 0 0 1 1 1 1 AAA-like domain CbiA PF01656.23 EFC49364.1 - 0.0015 18.6 0.1 0.0032 17.5 0.1 1.5 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_24 PF13479.6 EFC49364.1 - 0.0019 18.0 0.0 0.004 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 EFC49364.1 - 0.014 15.2 0.3 0.027 14.2 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 EFC49364.1 - 0.02 15.3 0.0 0.064 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 EFC49364.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 EFC49364.1 - 0.03 13.7 0.0 0.057 12.7 0.0 1.6 1 1 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 EFC49364.1 - 0.033 13.9 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 EFC49364.1 - 0.061 13.8 0.0 0.19 12.2 0.0 1.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Phage_Nu1 PF07471.12 EFC49364.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 PhoD PF09423.10 EFC49366.1 - 6.8e-09 35.2 3.3 1e-07 31.4 3.3 2.1 1 1 0 1 1 1 1 PhoD-like phosphatase DUF4149 PF13664.6 EFC49366.1 - 0.28 11.5 0.0 0.28 11.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4149) SWIRM PF04433.17 EFC49367.1 - 1.3e-25 89.5 0.2 4.2e-25 87.9 0.2 1.9 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 EFC49367.1 - 2.8e-21 75.3 13.7 2.8e-21 75.3 13.7 1.9 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 EFC49367.1 - 7e-11 42.1 0.2 1.9e-10 40.8 0.2 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC49367.1 - 3.7e-06 27.1 0.6 3.7e-06 27.1 0.6 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain BLI1 PF17324.2 EFC49367.1 - 0.0093 16.6 3.1 0.02 15.5 3.1 1.6 1 0 0 1 1 1 1 BLOC-1 interactor 1 PRP9_N PF16958.5 EFC49367.1 - 1.2 9.1 11.5 9.8 6.2 0.2 2.9 3 0 0 3 3 3 0 Pre-mRNA-splicing factor PRP9 N-terminus HIP1_clath_bdg PF16515.5 EFC49367.1 - 2.5 8.8 13.4 3.2 8.4 11.4 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Ras PF00071.22 EFC49368.1 - 7.4e-34 116.7 0.2 8.7e-34 116.5 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49368.1 - 5.9e-24 84.6 0.2 8.8e-24 84.0 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49368.1 - 4.8e-09 35.9 0.5 5.4e-09 35.7 0.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC49368.1 - 7.4e-08 32.0 0.3 8.9e-08 31.8 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC49368.1 - 0.0015 18.1 0.1 0.069 12.7 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DLIC PF05783.11 EFC49368.1 - 0.016 14.0 1.2 2.3 6.9 0.0 2.0 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) FeoB_N PF02421.18 EFC49368.1 - 0.1 12.1 0.1 13 5.3 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B MMR_HSR1 PF01926.23 EFC49368.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase SBP_bac_3 PF00497.20 EFC49369.1 - 1.2e-17 64.1 0.0 4.9e-17 62.1 0.0 1.8 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 CcmH PF03918.14 EFC49369.1 - 0.0096 15.2 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein Lig_chan-Glu_bd PF10613.9 EFC49369.1 - 0.14 12.4 0.0 1.8 8.8 0.0 2.3 1 1 0 1 1 1 0 Ligated ion channel L-glutamate- and glycine-binding site Glyco_transf_49 PF13896.6 EFC49370.1 - 4.1e-13 49.4 0.8 1.7e-12 47.4 0.8 1.9 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan YrhK PF14145.6 EFC49371.1 - 2.3e-16 59.4 29.4 7.6e-09 35.3 3.4 3.8 3 1 0 3 3 3 3 YrhK-like protein SRP14 PF02290.15 EFC49371.1 - 0.044 14.2 1.6 0.2 12.0 1.6 2.1 1 0 0 1 1 1 0 Signal recognition particle 14kD protein DUF4225 PF13988.6 EFC49371.1 - 2.2 7.8 4.3 1.1 8.7 1.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4225) YebO PF13974.6 EFC49371.1 - 5.5 7.1 5.4 27 4.9 3.6 3.1 2 1 0 2 2 2 0 YebO-like protein CAF-1_p150 PF11600.8 EFC49372.1 - 0.12 12.1 31.1 0.31 10.7 31.1 1.7 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal CDC45 PF02724.14 EFC49372.1 - 0.14 10.5 9.1 0.24 9.6 9.1 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA_22 PF13401.6 EFC49373.1 - 5.9e-06 26.6 0.1 1.6e-05 25.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFC49373.1 - 0.00017 20.9 0.1 0.00064 19.0 0.0 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA PF00004.29 EFC49373.1 - 0.00052 20.4 0.1 0.0024 18.3 0.1 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC49373.1 - 0.016 15.6 0.0 0.17 12.2 0.0 2.4 2 1 0 2 2 2 0 AAA ATPase domain SHOCT PF09851.9 EFC49373.1 - 0.043 13.6 0.6 0.1 12.4 0.6 1.7 1 0 0 1 1 1 0 Short C-terminal domain GlcV_C_terminal PF17847.1 EFC49373.1 - 0.087 13.3 0.3 0.27 11.7 0.0 1.9 2 0 0 2 2 2 0 Glucose ABC transporter C-terminal domain AAA_14 PF13173.6 EFC49373.1 - 0.19 11.7 1.7 0.64 10.0 0.5 2.5 1 1 1 2 2 2 0 AAA domain Pkinase PF00069.25 EFC49374.1 - 1.2e-29 103.5 0.3 1.2e-29 103.5 0.3 3.0 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49374.1 - 3.3e-15 56.1 0.4 9.3e-14 51.3 0.1 2.5 2 0 0 2 2 2 1 Protein tyrosine kinase HEAT PF02985.22 EFC49375.1 - 2.1e-54 176.8 23.7 1.9e-05 24.5 0.0 14.9 15 0 0 15 15 15 12 HEAT repeat HEAT_2 PF13646.6 EFC49375.1 - 5.4e-38 129.3 2.5 6e-11 42.6 0.0 6.9 3 2 3 6 6 6 6 HEAT repeats Vac14_Fab1_bd PF12755.7 EFC49375.1 - 5.2e-18 65.4 3.7 5.1e-07 30.2 0.0 8.1 3 3 8 11 11 11 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 EFC49375.1 - 1.4e-17 63.8 2.6 0.05 14.1 0.0 9.4 7 2 3 10 10 10 4 HEAT-like repeat Adaptin_N PF01602.20 EFC49375.1 - 1.2e-10 40.6 10.2 1.6e-07 30.3 3.5 3.9 1 1 2 4 4 4 4 Adaptin N terminal region Cnd1 PF12717.7 EFC49375.1 - 3e-10 40.4 10.7 0.001 19.1 0.2 5.4 1 1 3 5 5 5 4 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 EFC49375.1 - 8.2e-07 29.2 3.1 0.55 10.4 0.0 5.1 3 1 2 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 EFC49375.1 - 9.2e-06 25.4 3.6 0.12 11.9 0.1 5.0 1 1 4 6 6 6 3 CLASP N terminal TAF6_C PF07571.13 EFC49375.1 - 3.4e-05 24.1 0.1 1.7 9.1 0.0 5.1 4 1 0 4 4 4 1 TAF6 C-terminal HEAT repeat domain Cohesin_HEAT PF12765.7 EFC49375.1 - 0.0094 16.2 3.3 74 3.8 0.0 6.3 7 0 0 7 7 7 0 HEAT repeat associated with sister chromatid cohesion Ecm29 PF13001.7 EFC49375.1 - 0.013 14.2 1.7 11 4.5 0.1 4.0 4 3 0 4 4 4 0 Proteasome stabiliser Arm PF00514.23 EFC49375.1 - 0.17 12.0 4.0 3.6 7.8 0.0 5.1 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat M11L PF11099.8 EFC49375.1 - 0.67 10.2 3.0 17 5.7 0.0 4.2 2 2 0 3 3 3 0 Apoptosis regulator M11L like DNA_pol_B_palm PF14792.6 EFC49376.1 - 3.3e-28 98.2 0.2 2.8e-26 92.0 0.2 2.2 1 1 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 EFC49376.1 - 2.8e-20 72.3 0.0 8.6e-20 70.7 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 EFC49376.1 - 6.8e-16 57.8 0.4 1.3e-15 56.9 0.4 1.5 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda NTP_transf_2 PF01909.23 EFC49376.1 - 0.0045 17.2 0.8 0.0098 16.2 0.7 1.7 1 1 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 EFC49376.1 - 0.0046 17.0 0.3 0.014 15.5 0.3 1.9 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase Cdd1 PF11731.8 EFC49376.1 - 0.0079 16.4 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Pathogenicity locus IMS_HHH PF11798.8 EFC49376.1 - 0.042 14.2 0.0 0.095 13.1 0.0 1.6 1 0 0 1 1 1 0 IMS family HHH motif MG3 PF17791.1 EFC49376.1 - 0.11 12.8 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 Macroglobulin domain MG3 HHH_5 PF14520.6 EFC49376.1 - 0.15 12.7 0.0 0.36 11.5 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain FKBP_C PF00254.28 EFC49377.1 - 2.4e-29 101.5 0.1 2.7e-29 101.3 0.1 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase His_Phos_1 PF00300.22 EFC49378.1 - 1.2e-36 126.3 0.0 1.6e-28 99.8 0.0 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Membr_traf_MHD PF10540.9 EFC49378.1 - 0.023 14.8 0.0 0.041 14.1 0.0 1.5 1 0 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain ubiquitin PF00240.23 EFC49379.1 - 0.0003 20.5 0.1 0.00094 18.9 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin family Zn_clus PF00172.18 EFC49380.1 - 7e-07 29.3 11.3 1.3e-06 28.4 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zinc_ribbon_13 PF09855.9 EFC49380.1 - 0.024 14.8 0.2 0.024 14.8 0.2 3.3 3 0 0 3 3 3 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) SR-25 PF10500.9 EFC49380.1 - 3.6 7.1 10.8 7.3 6.1 10.8 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ERCC4 PF02732.15 EFC49381.1 - 9.4e-19 68.1 2.5 2e-17 63.9 0.0 3.0 2 1 0 2 2 2 1 ERCC4 domain TusA PF01206.17 EFC49381.1 - 0.077 12.8 0.0 1.3 8.9 0.0 3.0 4 0 0 4 4 4 0 Sulfurtransferase TusA DUF3287 PF11690.8 EFC49382.1 - 0.034 13.9 0.1 0.051 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) FliD_C PF07195.12 EFC49382.1 - 0.085 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Pkinase PF00069.25 EFC49383.1 - 6.5e-44 150.3 6.2 6.6e-36 124.0 0.8 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49383.1 - 4.6e-27 94.9 1.2 9.4e-20 71.0 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase IQ PF00612.27 EFC49383.1 - 0.00024 20.6 0.0 0.00082 19.0 0.0 2.0 1 0 0 1 1 1 1 IQ calmodulin-binding motif RIO1 PF01163.22 EFC49383.1 - 0.00027 20.6 0.0 0.00027 20.6 0.0 2.3 3 0 0 3 3 3 1 RIO1 family Kdo PF06293.14 EFC49383.1 - 0.0054 16.1 0.0 3 7.1 0.0 2.7 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 EFC49383.1 - 0.0074 15.1 11.8 6.5 5.4 9.4 4.1 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 EFC49383.1 - 0.0076 16.2 0.0 4.6 7.1 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family SR-25 PF10500.9 EFC49383.1 - 0.33 10.5 11.4 0.61 9.6 11.4 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 EFC49383.1 - 3 8.2 7.9 41 4.6 7.5 2.6 3 0 0 3 3 3 0 Early growth response N-terminal domain G-alpha PF00503.20 EFC49384.1 - 6.6e-115 384.0 9.6 7.9e-115 383.8 9.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC49384.1 - 6.3e-15 55.1 0.4 5.1e-10 39.1 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC49384.1 - 7.4e-07 28.8 1.2 0.00011 21.6 0.3 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC49384.1 - 0.0038 17.4 0.5 2 8.6 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC49384.1 - 0.042 13.9 0.1 8.1 6.6 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 EFC49384.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Spatacsin_C PF14649.6 EFC49385.1 - 9.9e-85 284.3 4.3 9.9e-85 284.3 4.3 2.8 3 0 0 3 3 3 1 Spatacsin C-terminus RIC1 PF07064.13 EFC49385.1 - 8.9e-05 22.0 1.5 2.7 7.4 0.1 4.0 3 0 0 3 3 3 3 RIC1 DUF1670 PF07900.11 EFC49385.1 - 0.0032 16.8 0.5 0.013 14.9 0.5 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1670) Imm8 PF15586.6 EFC49385.1 - 0.054 13.5 0.2 4.3 7.4 0.0 3.4 2 0 0 2 2 2 0 Immunity protein 8 Mss4 PF04421.13 EFC49386.1 - 3.8e-16 59.0 0.1 6e-16 58.4 0.1 1.3 1 1 0 1 1 1 1 Mss4 protein Lar_restr_allev PF14354.6 EFC49386.1 - 0.029 14.8 0.2 0.064 13.6 0.2 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 EFC49386.1 - 0.033 14.3 0.2 0.32 11.1 0.0 2.1 2 0 0 2 2 2 0 Zinc ribbon domain DUF3797 PF12677.7 EFC49386.1 - 0.037 13.9 0.2 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) zf-trcl PF13451.6 EFC49386.1 - 0.092 12.7 0.3 0.64 10.0 0.0 2.2 2 0 0 2 2 2 0 Probable zinc-ribbon domain PGP_phosphatase PF09419.10 EFC49386.1 - 0.096 12.3 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase G-alpha PF00503.20 EFC49387.1 - 4e-61 207.2 11.3 9.9e-61 205.8 11.3 1.7 1 0 0 1 1 1 1 G-protein alpha subunit TsaE PF02367.17 EFC49387.1 - 0.0029 17.6 0.0 0.0082 16.1 0.0 1.7 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Arf PF00025.21 EFC49387.1 - 0.0083 15.6 0.0 0.057 12.9 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family cobW PF02492.19 EFC49387.1 - 0.027 14.1 0.0 0.067 12.8 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ThiF PF00899.21 EFC49389.1 - 8.9e-47 159.5 0.0 4.5e-46 157.2 0.0 2.0 2 1 0 2 2 2 1 ThiF family UBA_e1_thiolCys PF10585.9 EFC49389.1 - 5e-08 33.2 7.4 9.8e-05 22.4 2.5 3.3 1 1 0 2 2 2 2 Ubiquitin-activating enzyme active site She9_MDM33 PF05546.11 EFC49389.1 - 0.021 14.6 1.9 0.03 14.1 0.2 2.1 2 0 0 2 2 2 0 She9 / Mdm33 family NAD_binding_7 PF13241.6 EFC49389.1 - 0.042 14.3 0.0 0.24 11.8 0.0 2.3 1 1 0 1 1 1 0 Putative NAD(P)-binding Pyr_redox PF00070.27 EFC49389.1 - 0.18 12.4 0.2 0.59 10.7 0.2 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IBR PF01485.21 EFC49390.1 - 2.4e-06 27.7 37.0 0.00068 19.8 9.5 3.8 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EFC49390.1 - 0.0037 17.2 4.5 0.0037 17.2 4.5 4.9 3 2 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 EFC49390.1 - 0.022 14.8 4.0 0.022 14.8 4.0 4.3 3 2 0 3 3 3 0 RING-type zinc-finger zf-C3HC4 PF00097.25 EFC49390.1 - 2.1 8.3 39.7 0.07 13.0 4.6 4.8 3 2 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Glyco_hydro_20 PF00728.22 EFC49391.1 - 2.3e-69 234.5 0.0 3.4e-69 233.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 EFC49391.1 - 3.8e-19 69.7 0.0 1.4e-18 67.8 0.0 2.0 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 EFC49391.1 - 0.0022 18.8 0.0 0.0045 17.8 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 LST1 PF05083.13 EFC49391.1 - 0.062 13.6 0.1 0.15 12.4 0.1 1.7 1 0 0 1 1 1 0 LST-1 protein CYYR1 PF10873.8 EFC49391.1 - 0.073 13.5 1.0 0.33 11.4 0.1 2.2 2 0 0 2 2 2 0 Cysteine and tyrosine-rich protein 1 DUF4476 PF14771.6 EFC49391.1 - 0.085 13.2 0.1 0.36 11.2 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) OppC_N PF12911.7 EFC49391.1 - 0.14 12.2 0.7 17 5.5 0.2 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C CD20 PF04103.15 EFC49391.1 - 0.34 11.0 5.5 0.64 10.1 1.8 2.3 2 0 0 2 2 2 0 CD20-like family Pkinase PF00069.25 EFC49392.1 - 4.6e-17 62.2 0.0 5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49392.1 - 2.2e-09 37.0 0.0 2.4e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC49392.1 - 0.055 12.4 0.0 0.07 12.1 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain EGF_2 PF07974.13 EFC49393.1 - 0.00014 22.1 10.2 0.00014 22.1 10.2 2.5 1 1 1 2 2 2 1 EGF-like domain EGF PF00008.27 EFC49393.1 - 0.00085 19.6 4.2 0.00085 19.6 4.2 2.9 3 1 0 3 3 3 1 EGF-like domain hEGF PF12661.7 EFC49393.1 - 0.09 13.4 7.8 0.09 13.4 7.8 3.8 4 0 0 4 4 4 0 Human growth factor-like EGF Mito_carr PF00153.27 EFC49394.1 - 1.2e-17 63.6 0.6 3.8e-07 29.9 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Rad9 PF04139.13 EFC49395.1 - 4.5e-39 134.4 2.1 7.7e-39 133.6 2.1 1.4 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 EFC49395.1 - 0.00035 19.8 0.5 0.00091 18.4 0.5 1.6 1 0 0 1 1 1 1 Hus1-like protein PCNA_N PF00705.18 EFC49395.1 - 0.17 11.6 1.5 0.49 10.1 0.3 2.1 2 0 0 2 2 2 0 Proliferating cell nuclear antigen, N-terminal domain Arf PF00025.21 EFC49396.1 - 9.4e-65 217.3 0.4 1.2e-64 216.9 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC49396.1 - 6.5e-14 52.2 0.0 9.8e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC49396.1 - 3.1e-11 43.1 0.0 3.8e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC49396.1 - 1.2e-09 37.8 1.8 0.00014 21.2 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC49396.1 - 1.3e-08 34.9 0.2 4.2e-08 33.3 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC49396.1 - 1.4e-07 31.2 0.0 1.9e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 EFC49396.1 - 1.7e-07 30.8 0.0 2.7e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC49396.1 - 0.00035 20.2 0.0 0.0011 18.6 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 EFC49396.1 - 0.013 14.5 0.0 0.6 9.0 0.0 2.3 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 EFC49396.1 - 0.016 15.7 0.0 0.026 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 EFC49396.1 - 0.019 15.2 0.0 0.059 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 EFC49396.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 EFC49396.1 - 0.07 12.9 0.0 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 EFC49396.1 - 0.084 12.4 0.0 1 8.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 EFC49396.1 - 0.1 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea 6PF2K PF01591.18 EFC49396.1 - 0.11 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA PF00004.29 EFC49397.1 - 1.7e-19 70.5 0.0 3.7e-19 69.5 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 EFC49397.1 - 2.1e-16 60.5 0.0 3e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal DUF815 PF05673.13 EFC49397.1 - 0.00033 19.9 0.0 0.00046 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 EFC49397.1 - 0.0013 19.2 0.0 0.003 18.0 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 EFC49397.1 - 0.0037 17.8 0.0 0.029 14.9 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 EFC49397.1 - 0.0063 16.2 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 EFC49397.1 - 0.0088 16.1 0.0 0.022 14.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC49397.1 - 0.014 15.7 0.1 0.071 13.4 0.0 2.1 2 1 0 2 2 2 0 AAA domain RuvB_N PF05496.12 EFC49397.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 EFC49397.1 - 0.027 15.0 0.0 0.055 14.0 0.0 1.6 2 1 0 2 2 1 0 ABC transporter AAA_33 PF13671.6 EFC49397.1 - 0.04 14.1 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 EFC49397.1 - 0.048 13.2 0.0 0.1 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFC49397.1 - 0.051 13.3 0.0 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 EFC49397.1 - 0.052 13.9 0.0 0.15 12.4 0.0 2.0 1 1 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 EFC49397.1 - 0.063 13.2 0.7 0.45 10.4 0.0 2.5 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea NACHT PF05729.12 EFC49397.1 - 0.13 12.1 0.1 8.9 6.2 0.0 2.4 1 1 1 2 2 2 0 NACHT domain GSHPx PF00255.19 EFC49399.1 - 4.2e-43 145.3 1.3 5.5e-43 145.0 1.3 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 EFC49399.1 - 1.7e-08 34.4 0.3 4.1e-08 33.2 0.3 1.7 1 1 1 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EFC49399.1 - 9.4e-07 28.6 0.1 3.7e-06 26.7 0.1 1.8 2 0 0 2 2 2 1 Redoxin FH2 PF02181.23 EFC49400.1 - 8.4e-59 199.6 11.9 8.4e-59 199.6 11.9 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain RCC1_2 PF13540.6 EFC49401.1 - 6.3e-22 76.8 29.9 5.6e-05 22.8 0.0 11.2 11 0 0 11 11 11 6 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC49401.1 - 2.1e-21 76.3 17.9 0.0013 19.3 0.1 11.1 12 0 0 12 12 12 6 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC49401.1 - 2e-07 31.3 26.2 0.00046 20.5 11.3 3.1 2 0 0 2 2 2 2 EGF-like domain EOS1 PF12326.8 EFC49402.1 - 1.8 8.5 5.9 0.45 10.4 1.1 2.0 2 0 0 2 2 2 0 N-glycosylation protein Pkinase PF00069.25 EFC49403.1 - 3e-33 115.3 2.5 3e-33 115.3 2.5 3.8 2 1 2 4 4 4 1 Protein kinase domain PARP PF00644.20 EFC49403.1 - 1.5e-24 86.7 0.6 1.5e-24 86.7 0.6 2.7 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain Pkinase_Tyr PF07714.17 EFC49403.1 - 9.9e-24 84.0 5.2 1.7e-22 79.9 0.3 3.2 2 1 1 3 3 3 2 Protein tyrosine kinase Ank_2 PF12796.7 EFC49403.1 - 0.00067 20.2 0.0 0.0025 18.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC49403.1 - 0.0011 19.3 0.0 0.0042 17.5 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeat Kdo PF06293.14 EFC49403.1 - 0.0025 17.2 0.1 0.0065 15.9 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_4 PF13637.6 EFC49403.1 - 0.0064 17.0 0.0 0.019 15.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC49403.1 - 0.0094 16.4 0.0 0.038 14.5 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 EFC49403.1 - 0.028 14.8 0.0 0.075 13.4 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) SNARE PF05739.19 EFC49404.1 - 0.0085 16.1 0.2 0.025 14.5 0.2 1.9 1 0 0 1 1 1 1 SNARE domain TMPIT PF07851.13 EFC49404.1 - 9.7 5.3 18.9 2 7.6 5.6 2.6 1 1 2 3 3 3 0 TMPIT-like protein HATPase_c PF02518.26 EFC49405.1 - 5.7e-22 78.3 0.1 1.2e-21 77.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 EFC49405.1 - 9.8e-16 57.9 0.0 2.2e-15 56.8 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 EFC49405.1 - 3.5e-11 43.0 0.4 7.8e-11 41.8 0.4 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 EFC49405.1 - 0.00082 19.2 0.0 0.0025 17.7 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Aldo_ket_red PF00248.21 EFC49406.1 - 3.1e-78 262.9 0.1 3.5e-78 262.8 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Cohesin PF00963.18 EFC49407.1 - 0.039 14.2 1.3 0.075 13.3 1.3 1.5 1 0 0 1 1 1 0 Cohesin domain YfaZ PF07437.11 EFC49407.1 - 0.054 13.1 0.2 0.087 12.4 0.2 1.3 1 0 0 1 1 1 0 YfaZ precursor DUF945 PF06097.11 EFC49407.1 - 0.11 11.6 0.3 0.16 11.1 0.3 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) GST_N PF02798.20 EFC49408.1 - 2.2e-19 69.6 0.0 3.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 EFC49408.1 - 1.6e-18 66.9 0.0 2.5e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC49408.1 - 3e-16 59.5 0.0 4.5e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC49408.1 - 2e-14 53.5 0.0 2.5e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 EFC49408.1 - 1.8e-05 24.8 0.0 3.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC49408.1 - 0.0019 18.1 0.0 0.0034 17.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_S9 PF00380.19 EFC49409.1 - 1.1e-31 109.9 0.6 1.2e-31 109.7 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Chromo PF00385.24 EFC49410.1 - 5.2e-06 26.3 1.4 5.2e-06 26.3 1.4 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain 2OG-Fe_Oxy_2 PF10014.9 EFC49410.1 - 0.016 15.0 0.1 0.064 13.0 0.0 2.0 2 0 0 2 2 2 0 2OG-Fe dioxygenase ELM2 PF01448.24 EFC49410.1 - 0.12 13.1 1.0 0.47 11.2 1.0 2.0 1 0 0 1 1 1 0 ELM2 domain YIF1 PF03878.15 EFC49411.1 - 3.9e-60 203.4 8.2 4.6e-60 203.1 8.2 1.0 1 0 0 1 1 1 1 YIF1 Mito_carr PF00153.27 EFC49412.1 - 8.4e-15 54.5 0.0 0.00016 21.5 0.0 3.7 2 1 1 3 3 3 3 Mitochondrial carrier protein adh_short PF00106.25 EFC49413.1 - 3.4e-25 88.6 0.7 1.1e-23 83.8 0.7 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC49413.1 - 5.9e-15 55.4 0.0 1.7e-12 47.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC49413.1 - 0.0003 20.7 0.0 0.00052 20.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC49413.1 - 0.00085 18.9 0.1 0.0015 18.1 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 EFC49413.1 - 0.0026 17.1 0.4 0.015 14.6 0.2 2.3 1 1 1 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 EFC49413.1 - 0.0029 17.1 0.1 0.0038 16.7 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 EFC49413.1 - 0.018 15.3 0.1 0.032 14.5 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 EFC49413.1 - 0.05 13.7 0.2 0.23 11.5 0.1 2.1 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DnaJ_C PF01556.18 EFC49414.1 - 7e-18 65.1 0.4 9.1e-18 64.8 0.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain Arf PF00025.21 EFC49414.1 - 1.4e-14 54.0 0.1 2.3e-14 53.2 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC49414.1 - 0.00014 21.5 0.0 0.00022 20.8 0.0 1.4 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 EFC49414.1 - 0.00039 19.7 0.8 0.00072 18.8 0.1 1.9 2 0 0 2 2 2 1 G-protein alpha subunit Nudix_N PF12535.8 EFC49414.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Hydrolase of X-linked nucleoside diphosphate N terminal G-alpha PF00503.20 EFC49415.1 - 0.0014 17.9 11.0 0.014 14.6 9.0 2.7 2 1 0 2 2 2 1 G-protein alpha subunit Methyltransf_11 PF08241.12 EFC49416.1 - 3e-23 82.3 0.0 5.6e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC49416.1 - 6.5e-22 78.0 0.0 1.5e-21 76.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC49416.1 - 2.1e-20 73.0 0.0 4.3e-20 72.0 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC49416.1 - 3.8e-18 65.7 0.0 6.4e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 EFC49416.1 - 3.2e-13 49.8 0.0 4.7e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC49416.1 - 1.9e-12 47.8 0.0 3.9e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EFC49416.1 - 5.7e-05 22.8 0.0 0.00028 20.5 0.0 2.0 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW MTS PF05175.14 EFC49416.1 - 0.0034 16.9 0.0 0.0069 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltr_RsmB-F PF01189.17 EFC49416.1 - 0.0089 15.7 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_3 PF01596.17 EFC49416.1 - 0.023 13.9 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase DUF938 PF06080.12 EFC49416.1 - 0.034 13.9 0.0 0.054 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_15 PF09445.10 EFC49416.1 - 0.075 12.6 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 EFC49416.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 EFC49416.1 - 0.084 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase CMAS PF02353.20 EFC49416.1 - 0.095 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF4470 PF14737.6 EFC49416.1 - 0.12 12.6 0.0 0.8 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4470) Methyltransf_32 PF13679.6 EFC49416.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain DUF4116 PF13475.6 EFC49417.1 - 0.0017 18.0 0.3 0.01 15.5 0.0 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4116) Imm59 PF15597.6 EFC49419.1 - 0.0087 16.5 1.5 0.27 11.7 0.2 2.5 2 0 0 2 2 2 1 Immunity protein 59 Hexokinase_1 PF00349.21 EFC49419.1 - 0.083 12.8 0.5 0.16 11.9 0.5 1.4 1 0 0 1 1 1 0 Hexokinase PARP PF00644.20 EFC49420.1 - 1.8e-22 79.9 12.1 1.2e-21 77.3 0.7 3.0 2 1 1 3 3 3 2 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 EFC49420.1 - 0.0056 16.4 0.1 0.0091 15.8 0.1 1.2 1 0 0 1 1 1 1 Exotoxin A catalytic ART-PolyVal PF18760.1 EFC49420.1 - 0.012 16.6 0.1 0.026 15.6 0.1 1.5 1 0 0 1 1 1 0 ADP-Ribosyltransferase in polyvalent proteins CCDC24 PF15669.5 EFC49420.1 - 0.17 11.8 2.2 0.17 11.7 0.7 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Pkinase PF00069.25 EFC49421.1 - 1.4e-64 218.0 0.1 2.7e-64 217.1 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49421.1 - 1.3e-35 123.0 0.0 2.3e-35 122.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 EFC49421.1 - 6.4e-12 44.1 6.1 0.00074 18.9 0.0 4.9 5 0 0 5 5 4 3 EF hand EF-hand_7 PF13499.6 EFC49421.1 - 7.1e-10 39.2 5.2 6e-05 23.4 0.2 3.8 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC49421.1 - 4.3e-08 32.5 1.1 0.011 15.6 0.0 4.8 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 EFC49421.1 - 9.6e-07 28.6 0.3 3.9 7.4 0.0 4.9 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC49421.1 - 2.9e-06 26.5 0.7 0.00073 18.9 0.0 3.2 3 0 0 3 3 3 1 EF hand Kinase-like PF14531.6 EFC49421.1 - 2.1e-05 24.0 0.0 5.1e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 EFC49421.1 - 0.0017 18.4 0.1 0.0077 16.2 0.1 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC49421.1 - 0.0018 17.3 0.2 0.0018 17.3 0.2 2.4 3 0 0 3 3 2 1 Haspin like kinase domain Toxin_15 PF07906.13 EFC49421.1 - 0.005 16.5 0.2 0.011 15.4 0.2 1.6 1 0 0 1 1 1 1 ShET2 enterotoxin, N-terminal region Choline_kinase PF01633.20 EFC49421.1 - 0.0086 15.7 1.1 0.056 13.0 0.1 2.3 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 EFC49421.1 - 0.014 14.8 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RD3 PF14473.6 EFC49423.1 - 0.1 12.4 1.9 0.2 11.5 1.9 1.5 1 0 0 1 1 1 0 RD3 protein F-box-like PF12937.7 EFC49424.1 - 0.00096 19.0 0.2 0.0029 17.5 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC49424.1 - 0.0038 17.1 0.1 0.011 15.6 0.1 1.8 1 0 0 1 1 1 1 F-box domain DUF1664 PF07889.12 EFC49425.1 - 3e-09 37.0 22.0 1.9e-05 24.7 9.3 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF1664) WEMBL PF05701.11 EFC49425.1 - 2e-08 33.4 13.7 2e-08 33.4 13.7 1.9 2 1 0 2 2 1 1 Weak chloroplast movement under blue light LPP PF04728.13 EFC49425.1 - 1.1e-07 32.1 20.2 0.029 14.8 2.4 5.3 2 1 4 6 6 5 4 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 EFC49425.1 - 1.5e-07 31.5 15.6 1.9e-06 28.0 2.9 3.5 2 2 2 4 4 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 EFC49425.1 - 2.9e-07 30.6 22.8 0.00077 19.5 14.1 2.7 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus V-SNARE PF05008.15 EFC49425.1 - 6.8e-06 26.4 9.4 0.0026 18.1 1.6 3.4 1 1 2 3 3 3 3 Vesicle transport v-SNARE protein N-terminus DUF2730 PF10805.8 EFC49425.1 - 8.8e-06 25.8 11.0 0.0047 17.0 3.0 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF2730) TPR_MLP1_2 PF07926.12 EFC49425.1 - 4.3e-05 23.6 0.9 0.0056 16.7 0.2 3.7 2 1 2 4 4 3 2 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 EFC49425.1 - 6.6e-05 22.9 0.7 0.32 11.1 0.0 3.1 1 1 2 3 3 3 2 TolA binding protein trimerisation Fez1 PF06818.15 EFC49425.1 - 8.9e-05 23.0 7.4 8.9e-05 23.0 7.4 2.9 1 1 1 2 2 1 1 Fez1 Spc7 PF08317.11 EFC49425.1 - 0.00013 21.0 14.5 0.0005 19.0 5.8 3.0 2 1 1 3 3 3 2 Spc7 kinetochore protein COG5 PF10392.9 EFC49425.1 - 0.00014 22.1 9.1 0.019 15.1 1.0 3.3 1 1 2 3 3 3 2 Golgi transport complex subunit 5 DUF4201 PF13870.6 EFC49425.1 - 0.00041 20.1 17.2 0.00041 20.1 17.2 2.2 2 1 0 2 2 1 1 Domain of unknown function (DUF4201) Atg14 PF10186.9 EFC49425.1 - 0.00067 18.8 9.9 0.00067 18.8 9.9 2.4 2 1 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 KxDL PF10241.9 EFC49425.1 - 0.0008 19.6 18.1 0.12 12.6 1.7 4.9 1 1 3 4 4 4 2 Uncharacterized conserved protein HsbA PF12296.8 EFC49425.1 - 0.00086 19.7 14.2 0.03 14.7 9.3 3.4 1 1 1 2 2 2 2 Hydrophobic surface binding protein A ADIP PF11559.8 EFC49425.1 - 0.002 18.2 6.5 0.002 18.2 6.5 3.8 2 2 2 4 4 3 1 Afadin- and alpha -actinin-Binding XhlA PF10779.9 EFC49425.1 - 0.0037 17.4 41.0 0.0041 17.3 9.6 4.3 2 1 2 4 4 3 3 Haemolysin XhlA Filament PF00038.21 EFC49425.1 - 0.0043 16.7 25.1 0.015 14.9 1.8 2.8 2 1 1 3 3 3 2 Intermediate filament protein DivIC PF04977.15 EFC49425.1 - 0.0049 16.6 7.4 1.2 9.0 0.6 3.9 1 1 3 4 4 4 2 Septum formation initiator DUF2968 PF11180.8 EFC49425.1 - 0.0061 16.2 0.1 0.33 10.6 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF2968) FlaC_arch PF05377.11 EFC49425.1 - 0.0076 16.6 31.4 0.1 13.0 6.2 5.4 2 1 4 6 6 4 3 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 EFC49425.1 - 0.01 15.1 6.3 0.037 13.3 4.5 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 EFC49425.1 - 0.01 15.7 8.2 0.01 15.7 8.2 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Phage_HK97_TLTM PF06120.11 EFC49425.1 - 0.011 15.0 13.6 0.011 15.0 13.6 3.3 1 1 1 3 3 2 0 Tail length tape measure protein Lectin_N PF03954.14 EFC49425.1 - 0.017 14.9 2.9 0.017 14.9 2.9 2.7 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain Macoilin PF09726.9 EFC49425.1 - 0.018 13.6 35.5 1.1 7.7 35.5 2.0 1 1 0 1 1 1 0 Macoilin family COG2 PF06148.11 EFC49425.1 - 0.019 15.1 12.5 1.3 9.2 0.9 4.2 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Bap31_Bap29_C PF18035.1 EFC49425.1 - 0.02 14.9 5.3 2.4 8.2 0.1 4.5 1 1 3 4 4 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Alanine_zipper PF11839.8 EFC49425.1 - 0.022 15.1 2.9 35 4.8 0.0 3.8 1 1 3 4 4 4 0 Alanine-zipper, major outer membrane lipoprotein DUF745 PF05335.13 EFC49425.1 - 0.034 13.9 5.6 0.055 13.2 4.5 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Laminin_II PF06009.12 EFC49425.1 - 0.045 13.8 23.5 0.082 12.9 14.5 3.3 1 1 2 3 3 3 0 Laminin Domain II Tup_N PF08581.10 EFC49425.1 - 0.07 13.4 18.8 1.3 9.4 8.1 4.2 2 1 1 3 3 2 0 Tup N-terminal BST2 PF16716.5 EFC49425.1 - 0.073 13.7 5.6 1.6 9.4 2.0 3.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF5082 PF16888.5 EFC49425.1 - 0.079 13.2 31.3 0.69 10.2 11.9 4.9 2 1 2 4 4 3 0 Domain of unknown function (DUF5082) DUF948 PF06103.11 EFC49425.1 - 0.085 13.1 18.8 0.15 12.3 9.1 3.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 EFC49425.1 - 0.096 13.2 0.1 0.096 13.2 0.1 3.2 2 2 1 3 3 2 0 Apg6 coiled-coil region Sec34 PF04136.15 EFC49425.1 - 0.098 12.5 14.5 0.055 13.4 2.1 3.5 2 1 1 3 3 3 0 Sec34-like family Bacillus_HBL PF05791.11 EFC49425.1 - 0.11 12.3 25.9 0.38 10.6 14.6 3.0 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) AAA_13 PF13166.6 EFC49425.1 - 0.15 10.7 40.0 6.6 5.3 40.0 2.3 1 1 0 1 1 1 0 AAA domain Cluap1 PF10234.9 EFC49425.1 - 0.23 10.8 28.8 0.078 12.4 12.5 3.0 2 1 1 3 3 3 0 Clusterin-associated protein-1 SKA1 PF07160.12 EFC49425.1 - 0.24 11.2 30.6 0.11 12.4 3.9 3.5 3 1 1 4 4 3 0 Spindle and kinetochore-associated protein 1 HIP1_clath_bdg PF16515.5 EFC49425.1 - 0.27 11.9 17.8 0.21 12.2 0.7 4.1 2 2 2 4 4 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 EFC49425.1 - 0.29 10.5 4.3 0.55 9.5 4.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TACC_C PF05010.14 EFC49425.1 - 0.35 10.6 26.0 0.057 13.2 10.6 3.2 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2746 PF10874.8 EFC49425.1 - 0.61 10.5 15.5 6.5 7.2 5.9 3.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2746) DUF812 PF05667.11 EFC49425.1 - 0.83 8.5 38.5 4.9 5.9 3.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF812) TMPIT PF07851.13 EFC49425.1 - 0.94 8.7 27.0 0.022 14.1 13.3 3.1 2 1 1 3 3 3 0 TMPIT-like protein Med9 PF07544.13 EFC49425.1 - 1.2 9.3 11.1 1.6e+02 2.5 10.8 3.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF16 PF01519.16 EFC49425.1 - 1.4 9.5 29.7 0.039 14.4 6.1 3.8 1 1 3 4 4 3 0 Protein of unknown function DUF16 Cob_adeno_trans PF01923.18 EFC49425.1 - 1.4 9.0 8.3 1.3 9.1 3.2 3.0 1 1 1 3 3 2 0 Cobalamin adenosyltransferase FPP PF05911.11 EFC49425.1 - 1.5 6.9 42.7 1.2e+02 0.6 42.4 2.2 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil Fzo_mitofusin PF04799.13 EFC49425.1 - 2 7.9 12.0 7.2e+02 -0.4 12.0 3.2 1 1 0 1 1 1 0 fzo-like conserved region DUF1515 PF07439.11 EFC49425.1 - 2.3 8.3 13.1 25 4.9 1.9 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) USP8_interact PF08941.10 EFC49425.1 - 2.5 7.9 13.4 77 3.0 9.1 3.4 2 1 0 2 2 1 0 USP8 interacting PI_PP_I PF18363.1 EFC49425.1 - 2.7 8.2 15.4 26 5.1 6.5 3.7 1 1 2 3 3 3 0 Phosphoinositide phosphatase insertion domain CALCOCO1 PF07888.11 EFC49425.1 - 2.8 6.7 22.3 0.006 15.5 9.2 2.4 2 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2203 PF09969.9 EFC49425.1 - 4.2 8.1 15.5 3.4 8.4 0.7 3.6 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) DASH_Duo1 PF08651.10 EFC49425.1 - 5.3 6.9 22.8 5.8 6.8 2.6 4.3 1 1 2 3 3 3 0 DASH complex subunit Duo1 Img2 PF05046.14 EFC49425.1 - 5.3 7.4 8.4 9.1e+02 0.2 8.3 3.2 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) CC2-LZ PF16516.5 EFC49425.1 - 6.4 7.2 20.2 1.3 9.4 2.5 3.9 2 1 2 4 4 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Snapin_Pallidin PF14712.6 EFC49425.1 - 6.7 7.2 16.5 10 6.6 10.2 3.0 1 1 1 2 2 2 0 Snapin/Pallidin YscO-like PF16789.5 EFC49425.1 - 7.5 6.6 17.8 20 5.2 11.8 2.9 2 1 0 2 2 2 0 YscO-like protein TMF_TATA_bd PF12325.8 EFC49425.1 - 7.8 6.8 27.6 0.032 14.4 3.5 4.6 2 2 1 5 5 4 0 TATA element modulatory factor 1 TATA binding LRR_6 PF13516.6 EFC49426.1 - 1.6e-22 77.6 0.7 0.00018 21.3 0.0 4.9 5 0 0 5 5 5 4 Leucine Rich repeat LRR_4 PF12799.7 EFC49426.1 - 4.4e-15 55.6 13.3 4.6e-05 23.7 0.3 3.2 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49426.1 - 6.4e-14 51.5 12.0 2.9e-07 30.1 0.6 2.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_1 PF00560.33 EFC49426.1 - 1e-07 31.5 0.1 2 9.3 0.0 4.8 5 0 0 5 5 5 1 Leucine Rich Repeat ApoB100_C PF12491.8 EFC49426.1 - 0.00037 20.4 8.0 0.43 10.6 0.1 4.6 1 1 3 4 4 4 2 Apolipoprotein B100 C terminal NKWYS PF10364.9 EFC49426.1 - 0.0011 19.1 1.8 0.18 11.9 0.3 2.2 1 1 1 2 2 2 2 Putative capsular polysaccharide synthesis protein LRR_9 PF14580.6 EFC49426.1 - 0.0016 17.9 0.8 0.015 14.8 0.1 1.9 1 1 1 2 2 2 1 Leucine-rich repeat DUF5490 PF17593.2 EFC49426.1 - 0.027 14.5 0.2 13 5.8 0.0 3.6 1 1 2 3 3 3 0 Family of unknown function (DUF5490) DUF4347 PF14252.6 EFC49426.1 - 0.035 13.9 0.1 9.5 6.0 0.0 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4347) UPF0193 PF05250.11 EFC49426.1 - 0.12 12.2 4.8 1 9.1 0.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0193) Beta_helix PF13229.6 EFC49426.1 - 0.2 11.5 2.4 0.76 9.6 2.4 1.9 1 1 0 1 1 1 0 Right handed beta helix region UQ_con PF00179.26 EFC49427.1 - 6.4e-17 61.5 3.3 6.6e-17 61.5 0.4 2.1 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme DUF5383 PF17355.2 EFC49427.1 - 0.0083 16.5 0.6 0.013 15.8 0.6 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5383) RWD PF05773.22 EFC49427.1 - 0.24 11.7 1.5 0.35 11.2 1.4 1.7 1 1 0 1 1 1 0 RWD domain GDI PF00996.18 EFC49428.1 - 2.8e-201 668.7 2.5 3.2e-201 668.5 2.5 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 EFC49428.1 - 0.15 12.3 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Aminotran_3 PF00202.21 EFC49429.1 - 1.6e-90 303.7 0.0 1.9e-90 303.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III F-box-like PF12937.7 EFC49430.1 - 0.0053 16.6 0.5 0.012 15.5 0.0 1.8 2 0 0 2 2 2 1 F-box-like Trypsin PF00089.26 EFC49431.1 - 1.2e-39 136.4 7.8 1.5e-39 136.1 7.8 1.1 1 0 0 1 1 1 1 Trypsin Endotoxin_C PF03944.14 EFC49432.1 - 1.1 9.6 4.2 5.3 7.4 0.2 3.2 3 0 0 3 3 3 0 delta endotoxin Trp_halogenase PF04820.14 EFC49434.1 - 0.0011 17.9 0.0 1.3 7.8 0.0 3.1 3 0 0 3 3 3 3 Tryptophan halogenase Pyr_redox_2 PF07992.14 EFC49434.1 - 0.039 13.2 0.1 0.67 9.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 EFC49434.1 - 0.11 11.7 0.0 0.44 9.7 0.0 1.9 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 EFC49434.1 - 0.15 12.6 0.5 0.88 10.2 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ABC_tran PF00005.27 EFC49436.1 - 4.8e-46 156.7 3.0 4.5e-26 92.0 0.1 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 EFC49436.1 - 2.2e-43 148.9 40.6 1.2e-28 100.6 12.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 EFC49436.1 - 2.8e-08 33.5 5.0 0.068 12.6 0.0 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 EFC49436.1 - 3.4e-07 30.4 0.4 0.063 13.4 0.0 3.9 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_22 PF13401.6 EFC49436.1 - 1.6e-06 28.4 0.3 0.011 16.0 0.1 3.4 2 1 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 EFC49436.1 - 2.2e-06 27.8 4.4 0.0013 18.8 0.0 3.6 4 1 0 5 5 3 2 Dynamin family RsgA_GTPase PF03193.16 EFC49436.1 - 7.4e-06 26.0 0.6 0.031 14.2 0.1 2.9 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 EFC49436.1 - 5.4e-05 23.0 1.8 0.18 11.5 0.0 3.5 3 1 0 3 3 3 2 AAA domain AAA_7 PF12775.7 EFC49436.1 - 7.7e-05 22.3 0.1 0.055 13.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_21 PF13304.6 EFC49436.1 - 9e-05 22.4 2.8 2.4 7.9 0.0 4.3 3 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFC49436.1 - 0.0001 21.9 0.5 0.58 9.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 EFC49436.1 - 0.00013 22.4 0.2 0.074 13.4 0.0 2.9 3 0 0 3 3 2 1 AAA ATPase domain T2SSE PF00437.20 EFC49436.1 - 0.00016 20.8 0.2 0.44 9.6 0.0 3.2 3 0 0 3 3 3 1 Type II/IV secretion system protein Septin PF00735.18 EFC49436.1 - 0.00025 20.4 0.1 0.29 10.4 0.0 2.6 2 0 0 2 2 2 2 Septin IstB_IS21 PF01695.17 EFC49436.1 - 0.00028 20.6 0.1 1.1 9.0 0.0 3.6 3 0 0 3 3 3 1 IstB-like ATP binding protein AIG1 PF04548.16 EFC49436.1 - 0.00074 18.9 1.0 2.1 7.6 0.0 3.4 3 0 0 3 3 3 2 AIG1 family Viral_helicase1 PF01443.18 EFC49436.1 - 0.0026 17.5 0.2 0.12 12.1 0.0 3.0 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 EFC49436.1 - 0.0028 18.0 0.2 1.1 9.7 0.0 3.4 3 0 0 3 3 2 1 RNA helicase IIGP PF05049.13 EFC49436.1 - 0.0039 16.3 0.6 0.68 8.9 0.1 2.7 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) NACHT PF05729.12 EFC49436.1 - 0.0068 16.3 0.1 6 6.8 0.0 2.8 3 0 0 3 3 2 0 NACHT domain DUF87 PF01935.17 EFC49436.1 - 0.0077 16.4 2.2 0.84 9.7 0.0 3.0 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_18 PF13238.6 EFC49436.1 - 0.0091 16.5 0.0 4.7 7.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 EFC49436.1 - 0.013 14.9 0.7 4.2 6.6 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA PF00004.29 EFC49436.1 - 0.013 15.9 2.7 0.57 10.6 0.1 4.1 4 1 0 4 4 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 EFC49436.1 - 0.016 15.0 0.1 0.2 11.4 0.2 2.7 2 1 0 2 2 2 0 DEAD/DEAH box helicase Roc PF08477.13 EFC49436.1 - 0.017 15.4 1.4 3.9 7.7 0.0 3.5 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 EFC49436.1 - 0.041 13.1 0.1 0.73 9.0 0.0 2.7 2 0 0 2 2 2 0 NB-ARC domain GTP_EFTU PF00009.27 EFC49436.1 - 0.042 13.4 0.0 4.1 6.9 0.0 3.3 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFC49436.1 - 0.046 13.5 0.0 2.6 7.8 0.0 2.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TrwB_AAD_bind PF10412.9 EFC49436.1 - 0.056 12.3 0.0 9.8 5.0 0.0 2.5 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_15 PF13175.6 EFC49436.1 - 0.083 12.6 16.8 4.1 7.0 0.0 3.7 3 1 0 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 EFC49436.1 - 0.11 12.7 0.0 25 5.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFC49436.1 - 0.14 11.7 0.2 16 5.0 0.0 2.6 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 EFC49436.1 - 0.15 12.1 0.1 26 4.8 0.0 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EFC49436.1 - 0.37 9.9 2.2 1.3 8.2 0.0 2.4 3 0 0 3 3 2 0 Protein of unknown function (DUF815) Mak16 PF04874.14 EFC49436.1 - 0.69 10.6 3.4 2.5 8.8 3.4 1.9 1 0 0 1 1 1 0 Mak16 protein C-terminal region Lipase_3 PF01764.25 EFC49437.1 - 0.0079 16.1 0.0 0.017 15.0 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) DUF2456 PF10445.9 EFC49437.1 - 0.12 12.5 0.6 0.32 11.1 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2456) DUF751 PF05421.11 EFC49437.1 - 0.35 11.6 2.7 7.6 7.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF751) DUF751 PF05421.11 EFC49438.1 - 0.006 17.3 2.0 2.3 9.0 0.1 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF751) DUF4834 PF16118.5 EFC49438.1 - 0.049 14.6 0.5 4.5 8.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 EFC49439.1 - 5e-09 36.6 0.0 9.9e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC49439.1 - 5.1e-07 30.1 0.0 1.1e-06 29.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC49439.1 - 3.8e-06 26.8 0.0 0.092 13.3 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 EFC49439.1 - 0.0007 19.8 0.0 0.84 10.0 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) DUF5049 PF16468.5 EFC49439.1 - 0.016 15.1 0.1 1.1 9.2 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5049) Ank PF00023.30 EFC49439.1 - 0.088 13.3 0.0 10 6.7 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Guanylate_cyc PF00211.20 EFC49440.1 - 1.4e-54 184.5 0.0 2.6e-54 183.6 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC49440.1 - 4.7e-15 55.7 0.1 1.2e-14 54.4 0.1 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC49440.1 - 1.3e-09 38.0 0.0 3e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 EFC49440.1 - 0.00018 21.7 0.0 0.00034 20.8 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC49440.1 - 0.0011 18.9 0.0 0.003 17.5 0.0 1.7 1 0 0 1 1 1 1 PAS domain C1-set PF07654.15 EFC49440.1 - 0.04 14.3 0.2 8 6.9 0.1 3.0 2 0 0 2 2 2 0 Immunoglobulin C1-set domain HNOBA PF07701.14 EFC49440.1 - 0.042 13.3 0.8 0.1 12.0 0.8 1.7 1 0 0 1 1 1 0 Heme NO binding associated PAS_10 PF13596.6 EFC49440.1 - 0.13 12.8 0.6 0.61 10.7 0.0 2.5 2 0 0 2 2 2 0 PAS domain FlaC_arch PF05377.11 EFC49441.1 - 4e-05 23.9 4.1 4e-05 23.9 4.1 2.0 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) UPF0184 PF03670.13 EFC49441.1 - 0.0049 17.2 1.3 0.0049 17.2 1.3 1.7 2 0 0 2 2 1 1 Uncharacterised protein family (UPF0184) Prominin PF05478.11 EFC49441.1 - 0.021 12.8 0.3 0.024 12.6 0.3 1.2 1 0 0 1 1 1 0 Prominin ThiD2 PF17792.1 EFC49441.1 - 0.026 15.0 2.0 0.052 14.0 2.0 1.5 1 0 0 1 1 1 0 ThiD2 family SKA2 PF16740.5 EFC49441.1 - 0.034 13.9 1.3 0.058 13.2 1.3 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Talin_middle PF09141.10 EFC49441.1 - 0.037 14.1 1.5 0.039 14.0 0.2 1.6 2 0 0 2 2 2 0 Talin, middle domain CLZ PF16526.5 EFC49441.1 - 0.051 13.9 0.5 0.14 12.5 0.5 1.7 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DivIVA PF05103.13 EFC49441.1 - 0.062 13.4 4.9 0.16 12.0 4.9 1.6 1 0 0 1 1 1 0 DivIVA protein TctB PF07331.11 EFC49441.1 - 0.26 11.6 3.4 0.25 11.6 2.2 1.5 2 0 0 2 2 1 0 Tripartite tricarboxylate transporter TctB family PIN_12 PF16289.5 EFC49441.1 - 0.28 11.7 9.8 0.38 11.2 9.4 1.4 1 1 0 1 1 1 0 PIN domain SOAR PF16533.5 EFC49441.1 - 0.3 11.1 2.3 0.75 9.8 0.3 2.3 2 0 0 2 2 2 0 STIM1 Orai1-activating region Laminin_II PF06009.12 EFC49441.1 - 0.53 10.3 6.1 0.32 11.0 0.4 2.3 1 1 1 2 2 2 0 Laminin Domain II V_ATPase_I PF01496.19 EFC49441.1 - 0.78 7.6 7.1 0.95 7.3 7.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SKA1 PF07160.12 EFC49441.1 - 0.84 9.4 11.3 1.6 8.5 11.3 1.5 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 CorA PF01544.18 EFC49441.1 - 0.92 8.8 6.3 0.73 9.1 4.5 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.12 EFC49441.1 - 1.4 9.0 3.8 0.6 10.2 1.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ISG65-75 PF11727.8 EFC49441.1 - 1.8 7.7 5.4 0.21 10.8 1.3 1.5 2 0 0 2 2 2 0 Invariant surface glycoprotein Fib_alpha PF08702.10 EFC49441.1 - 2.2 8.4 8.5 0.27 11.4 2.6 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Pup PF05639.11 EFC49441.1 - 4.4 8.3 13.9 0.37 11.7 0.7 3.0 3 0 0 3 3 3 0 Pup-like protein XhlA PF10779.9 EFC49441.1 - 9.9 6.4 8.0 1.6 9.0 3.5 2.0 2 0 0 2 2 1 0 Haemolysin XhlA NHL PF01436.21 EFC49442.1 - 2.2e-17 62.1 0.0 0.0039 17.2 0.0 5.4 5 0 0 5 5 5 4 NHL repeat zf-B_box PF00643.24 EFC49442.1 - 9.2e-08 32.1 3.2 9.2e-08 32.1 3.2 3.1 3 0 0 3 3 3 1 B-box zinc finger Arylesterase PF01731.20 EFC49442.1 - 0.00015 21.9 0.9 5.6 7.2 0.0 4.5 4 2 1 5 5 5 2 Arylesterase SGL PF08450.12 EFC49442.1 - 0.0042 16.7 0.0 3.2 7.3 0.0 2.7 3 0 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region 5_3_exonuc PF01367.20 EFC49442.1 - 2.4 8.8 5.1 3.7 8.2 0.5 2.8 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold FYVE_2 PF02318.16 EFC49442.1 - 2.4 8.4 22.2 0.21 11.8 1.9 3.6 3 0 0 3 3 3 0 FYVE-type zinc finger Remorin_C PF03763.13 EFC49442.1 - 6.6 6.7 9.6 17 5.3 9.6 1.6 1 0 0 1 1 1 0 Remorin, C-terminal region DUF3974 PF13120.6 EFC49443.1 - 0.082 13.0 3.6 0.69 10.0 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3974) DUF3974 PF13120.6 EFC49444.1 - 1.9 8.6 3.5 0.64 10.1 0.1 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3974) Lactamase_B PF00753.27 EFC49445.1 - 1.2e-17 64.6 0.2 1.6e-17 64.2 0.2 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC49445.1 - 5.2e-06 26.1 0.0 7e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 EFC49445.1 - 0.00081 18.9 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain DUF3808 PF10300.9 EFC49446.1 - 2.6e-24 85.8 0.6 2.6e-24 85.8 0.6 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_MalT PF17874.1 EFC49446.1 - 1.2e-05 24.9 0.0 2.4e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 EFC49446.1 - 0.0027 17.9 0.6 0.069 13.5 0.0 3.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49446.1 - 0.025 15.1 1.0 2 9.0 1.7 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49446.1 - 1.1 9.2 3.4 8.4 6.4 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49446.1 - 2.3 8.5 4.7 12 6.3 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ASC PF00858.24 EFC49447.1 - 1.1e-09 37.8 9.3 6.8e-06 25.3 3.2 2.9 1 1 2 3 3 3 2 Amiloride-sensitive sodium channel Kelch_3 PF13415.6 EFC49449.1 - 2.2e-24 85.2 4.3 6.4e-11 42.3 0.1 3.3 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC49449.1 - 4e-17 61.8 4.4 1.9e-06 28.0 0.3 3.5 2 1 1 3 3 3 3 Kelch motif Kelch_4 PF13418.6 EFC49449.1 - 9.9e-17 60.7 6.8 1.1e-05 25.4 0.3 3.4 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 EFC49449.1 - 2.7e-16 58.8 4.2 0.0001 21.8 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 EFC49449.1 - 4e-15 55.1 2.1 0.00011 22.1 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 EFC49449.1 - 1.1e-13 50.9 3.1 1.8e-06 27.8 0.0 3.5 3 0 0 3 3 3 2 Kelch motif HTH_micro PF17007.5 EFC49450.1 - 0.00068 18.6 0.4 0.0013 17.7 0.4 1.4 1 1 0 1 1 1 1 HTH-like Spc42p PF11544.8 EFC49450.1 - 0.026 14.5 0.6 0.069 13.2 0.6 1.7 1 0 0 1 1 1 0 Spindle pole body component Spc42p DED PF01335.21 EFC49450.1 - 0.036 14.4 0.1 0.12 12.7 0.0 1.9 1 1 1 2 2 2 0 Death effector domain mRNA_triPase PF02940.15 EFC49450.1 - 0.12 12.0 1.9 0.18 11.5 1.9 1.3 1 0 0 1 1 1 0 mRNA capping enzyme, beta chain Cofilin_ADF PF00241.20 EFC49451.1 - 1.2e-19 70.2 0.0 2.5e-19 69.3 0.0 1.5 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein Pox_polyA_pol_N PF12630.7 EFC49451.1 - 0.025 14.9 0.1 0.042 14.2 0.1 1.3 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain PMSR PF01625.21 EFC49452.1 - 6e-65 218.1 2.9 6.8e-65 217.9 2.9 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase RhoGAP PF00620.27 EFC49453.1 - 2.4e-35 121.6 1.6 3e-35 121.3 0.2 1.9 2 0 0 2 2 2 1 RhoGAP domain WW PF00397.26 EFC49453.1 - 6.9e-08 32.5 0.1 1.7e-07 31.2 0.1 1.7 1 0 0 1 1 1 1 WW domain Glyco_hyd_101C PF17451.2 EFC49453.1 - 0.011 16.1 0.9 0.036 14.4 0.9 1.9 1 0 0 1 1 1 0 Glycosyl hydrolase 101 beta sandwich domain Guanylate_cyc PF00211.20 EFC49455.1 - 1.6e-52 177.8 0.0 2.9e-52 177.0 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC49455.1 - 3.7e-14 52.8 0.1 2.4e-13 50.2 0.0 2.6 3 0 0 3 3 3 1 PAS domain PAS PF00989.25 EFC49455.1 - 4.5e-08 33.1 0.1 2e-07 31.0 0.0 2.1 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 EFC49455.1 - 0.00021 21.2 0.0 0.00067 19.6 0.0 1.9 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC49455.1 - 0.027 14.7 0.0 0.075 13.3 0.0 1.7 1 0 0 1 1 1 0 PAS fold K_channel_TID PF07941.11 EFC49456.1 - 0.88 10.1 3.0 6 7.4 0.2 2.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain EF-hand_7 PF13499.6 EFC49457.1 - 1.1e-21 77.0 0.9 1.1e-11 45.0 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC49457.1 - 1e-18 65.4 4.4 0.00021 20.6 0.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 EFC49457.1 - 9.1e-17 59.5 3.2 0.0024 17.6 0.0 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 EFC49457.1 - 1.6e-13 50.3 1.7 6.1e-08 32.4 0.3 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC49457.1 - 3e-11 42.3 1.5 0.00022 20.6 0.0 3.8 4 0 0 4 4 4 3 EF hand EF-hand_10 PF14788.6 EFC49457.1 - 0.0086 15.9 1.7 2.9 7.8 0.0 2.8 3 0 0 3 3 3 2 EF hand SPARC_Ca_bdg PF10591.9 EFC49457.1 - 0.011 16.0 0.3 1.2 9.4 0.1 2.5 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC49457.1 - 0.077 13.0 1.4 11 6.1 0.1 2.4 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand CHAP PF05257.16 EFC49458.1 - 0.0055 17.2 0.2 0.01 16.4 0.2 1.4 1 0 0 1 1 1 1 CHAP domain DUF4969 PF16339.5 EFC49458.1 - 0.09 13.1 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) DEAD PF00270.29 EFC49459.1 - 2.8e-11 43.5 1.2 5.2e-11 42.6 0.8 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC49459.1 - 0.057 13.8 0.2 0.33 11.3 0.2 2.4 1 1 0 1 1 1 0 Helicase conserved C-terminal domain TniB PF05621.11 EFC49459.1 - 0.077 12.4 0.2 0.65 9.4 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein CobA_CobO_BtuR PF02572.15 EFC49459.1 - 0.084 13.1 0.0 0.27 11.5 0.0 1.7 1 1 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP DUF2258 PF10015.9 EFC49460.1 - 0.053 13.7 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) 4HBT PF03061.22 EFC49461.1 - 2.2e-12 47.1 0.0 3.7e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Methyltransf_25 PF13649.6 EFC49461.1 - 1.1e-09 38.9 0.0 6.1e-09 36.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC49461.1 - 6.4e-09 35.8 1.0 3.2e-08 33.5 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC49461.1 - 1.5e-08 35.3 0.2 1.3e-07 32.3 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC49461.1 - 1.4e-06 28.8 0.0 5.4e-06 27.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC49461.1 - 0.00017 21.5 0.0 0.00038 20.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 EFC49461.1 - 0.62 10.0 0.0 0.62 10.0 0.0 2.5 4 0 0 4 4 4 0 Methyltransferase domain U-box PF04564.15 EFC49462.1 - 1.1e-15 57.6 1.6 2.1e-15 56.6 0.0 2.3 3 0 0 3 3 3 1 U-box domain zf-Nse PF11789.8 EFC49462.1 - 0.0002 21.1 0.1 0.00045 20.0 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 EFC49462.1 - 0.12 12.7 0.2 0.56 10.5 0.1 2.2 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 EFC49462.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF4116 PF13475.6 EFC49463.1 - 1.3e-103 338.5 10.5 2.4e-21 75.2 0.0 5.8 3 2 3 6 6 6 6 Domain of unknown function (DUF4116) Pkinase PF00069.25 EFC49463.1 - 1.3e-13 50.9 0.0 2.8e-13 49.8 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49463.1 - 5.6e-05 22.6 0.0 9.6e-05 21.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase AfsA PF03756.13 EFC49463.1 - 0.00012 22.1 0.0 1.4 8.9 0.0 3.2 1 1 2 3 3 3 2 A-factor biosynthesis hotdog domain NAD_binding_11 PF14833.6 EFC49463.1 - 0.015 15.5 0.2 5.1 7.4 0.0 3.7 1 1 4 5 5 5 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF5334 PF17268.2 EFC49463.1 - 0.038 14.3 0.1 12 6.3 0.1 3.3 3 1 0 3 3 3 0 Family of unknown function (DUF5334) CvfB_WH PF17783.1 EFC49463.1 - 0.038 13.8 0.0 1.1e+02 2.8 0.0 5.2 7 0 0 7 7 7 0 CvfB-like winged helix domain AF0941-like PF14591.6 EFC49463.1 - 0.053 14.1 10.4 14 6.3 4.7 3.8 1 1 1 2 2 2 0 AF0941-like DUF4853 PF16145.5 EFC49463.1 - 0.09 12.9 0.4 30 4.7 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4853) PilA4 PF18682.1 EFC49463.1 - 0.16 12.4 0.0 19 5.7 0.0 3.8 2 1 2 4 4 4 0 Pilin A4 GST_C PF00043.25 EFC49463.1 - 0.18 12.0 5.6 13 6.0 0.2 4.0 2 2 1 3 3 3 0 Glutathione S-transferase, C-terminal domain TraI_2B PF18340.1 EFC49463.1 - 0.19 11.9 1.8 13 5.9 0.1 3.1 2 1 0 2 2 2 0 DNA relaxase TraI 2B/2B-like domain DUF4051 PF13260.6 EFC49463.1 - 0.56 10.0 12.5 8.5 6.2 0.1 5.8 6 2 2 8 8 8 0 Protein of unknown function (DUF4051) G-alpha PF00503.20 EFC49464.1 - 3.3e-25 89.0 16.0 5.2e-13 48.9 3.6 2.2 2 0 0 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC49464.1 - 0.00071 19.6 0.0 0.86 9.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase 3Beta_HSD PF01073.19 EFC49465.1 - 2.1e-24 86.0 0.5 2.6e-24 85.7 0.5 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 EFC49465.1 - 8.6e-21 74.5 0.3 1.2e-20 74.0 0.3 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 EFC49465.1 - 3.2e-15 56.5 0.0 4.8e-15 55.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 EFC49465.1 - 9.1e-11 41.8 0.5 1.9e-10 40.7 0.3 1.6 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 EFC49465.1 - 8.2e-09 35.0 0.0 0.00025 20.3 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 EFC49465.1 - 4.3e-06 26.1 0.2 7e-06 25.4 0.2 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 EFC49465.1 - 1.4e-05 24.6 0.9 3.3e-05 23.5 0.9 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 EFC49465.1 - 0.011 15.2 0.2 0.19 11.2 0.0 2.5 3 0 0 3 3 3 0 short chain dehydrogenase HAS-barrel PF09378.10 EFC49465.1 - 0.084 13.0 0.5 0.29 11.3 0.1 2.2 2 1 0 2 2 2 0 HAS barrel domain Ras PF00071.22 EFC49466.1 - 7.9e-27 93.8 0.0 1.2e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49466.1 - 2.9e-06 27.5 0.0 6.4e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 EFC49466.1 - 0.14 11.1 0.0 0.19 10.7 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Pkinase PF00069.25 EFC49467.1 - 4.7e-39 134.3 0.1 6e-39 134.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49467.1 - 2.8e-26 92.3 0.0 3.5e-26 92.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC49467.1 - 8.7e-07 28.1 0.5 1.4e-06 27.3 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC49467.1 - 4.1e-06 26.3 0.1 0.02 14.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 EFC49467.1 - 1.2e-05 24.4 0.3 1.5e-05 24.1 0.3 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 EFC49467.1 - 0.042 13.8 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 EFC49467.1 - 0.091 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kelch_4 PF13418.6 EFC49470.1 - 6.1e-23 80.6 2.9 2.7e-06 27.3 0.1 4.6 3 1 1 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 EFC49470.1 - 6.8e-23 80.1 5.0 2.2e-06 27.7 0.0 4.2 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 EFC49470.1 - 7.4e-18 64.1 7.9 4.8e-07 29.6 0.1 4.7 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFC49470.1 - 5.1e-17 61.2 7.3 8.8e-07 28.4 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 EFC49470.1 - 8.8e-17 60.9 6.6 2e-06 27.9 0.1 6.1 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC49470.1 - 7.1e-15 54.3 5.8 3.6e-05 23.5 0.1 5.2 5 0 0 5 5 5 3 Kelch motif EGF_2 PF07974.13 EFC49472.1 - 1.4e-56 188.5 324.5 0.00029 21.1 10.0 23.0 23 0 0 23 23 23 22 EGF-like domain EGF PF00008.27 EFC49472.1 - 0.00058 20.1 30.9 0.0043 17.3 4.6 23.0 23 0 0 23 23 23 13 EGF-like domain B9-C2 PF07162.11 EFC49472.1 - 0.011 16.0 8.4 2.9 8.0 0.0 5.5 8 0 0 8 8 8 0 Ciliary basal body-associated, B9 protein TehB PF03848.14 EFC49472.1 - 1.7 8.0 5.8 48 3.3 0.0 4.3 5 0 0 5 5 5 0 Tellurite resistance protein TehB EGF_2 PF07974.13 EFC49473.1 - 3.5e-71 235.2 500.8 4.6e-05 23.7 5.4 31.6 31 0 0 31 31 31 31 EGF-like domain EGF PF00008.27 EFC49473.1 - 0.004 17.4 4.5 0.004 17.4 4.5 31.7 31 0 0 31 31 31 20 EGF-like domain LRR_4 PF12799.7 EFC49474.1 - 8e-08 32.5 20.4 0.0079 16.6 1.5 5.7 4 1 3 7 7 7 5 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC49474.1 - 2.6e-06 27.2 2.0 6.6e-06 25.9 2.0 1.7 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 EFC49474.1 - 0.00024 21.2 20.8 12 6.9 0.2 7.9 8 1 0 8 8 8 4 Leucine Rich Repeat F-box PF00646.33 EFC49474.1 - 0.00031 20.5 0.3 0.00031 20.5 0.3 2.9 3 0 0 3 3 3 1 F-box domain LRR_8 PF13855.6 EFC49474.1 - 0.0016 18.2 13.8 0.45 10.3 1.6 4.8 4 2 0 4 4 4 2 Leucine rich repeat LRR_6 PF13516.6 EFC49474.1 - 0.0087 16.0 25.2 0.22 11.7 0.2 7.5 9 0 0 9 9 9 3 Leucine Rich repeat Methyltransf_16 PF10294.9 EFC49475.1 - 2.4e-19 69.7 0.0 2.8e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFC49475.1 - 0.00015 21.3 0.0 0.00018 21.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PTEN_C2 PF10409.9 EFC49476.1 - 1.9e-08 34.2 0.7 4.9e-08 32.8 0.7 1.8 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 EFC49476.1 - 0.00027 20.7 0.0 0.00068 19.5 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC49476.1 - 0.00055 19.6 0.0 0.0011 18.6 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 EFC49476.1 - 0.0022 18.0 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Cupin_5 PF06172.11 EFC49476.1 - 0.099 12.8 0.0 0.28 11.4 0.0 1.7 2 0 0 2 2 2 0 Cupin superfamily (DUF985) PAXNEB PF05625.11 EFC49477.1 - 1.8e-77 261.0 10.1 2.4e-76 257.3 10.1 2.2 1 1 0 1 1 1 1 PAXNEB protein DUF4634 PF15465.6 EFC49477.1 - 0.11 12.8 0.1 0.32 11.3 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) DUF348 PF03990.14 EFC49478.1 - 0.017 14.9 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain DSPc PF00782.20 EFC49479.1 - 5.5e-12 45.6 0.1 9.3e-12 44.9 0.1 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC49479.1 - 4e-07 29.8 0.1 5.3e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC49479.1 - 3.3e-06 26.9 0.0 6.5e-06 25.9 0.0 1.4 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EFC49479.1 - 0.00071 19.6 0.0 0.00082 19.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFC49479.1 - 0.015 15.4 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EFC49479.1 - 0.12 11.9 1.1 0.16 11.5 0.8 1.5 1 1 0 1 1 1 0 Tyrosine phosphatase family DUF4252 PF14060.6 EFC49480.1 - 0.082 12.8 0.0 0.094 12.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) CAP_N PF01213.19 EFC49481.1 - 1.5e-39 136.4 0.7 1.8e-39 136.1 0.7 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal LZ3wCH PF18517.1 EFC49481.1 - 0.13 12.4 0.1 0.48 10.6 0.1 2.1 2 0 0 2 2 2 0 Leucine zipper with capping helix domain Bin3 PF06859.12 EFC49482.1 - 6e-34 116.9 1.4 6e-34 116.9 1.4 3.2 3 1 0 3 3 3 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_23 PF13489.6 EFC49482.1 - 5.3e-09 36.1 0.0 1.2e-08 34.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC49482.1 - 5.8e-08 32.7 1.4 0.0048 16.7 0.1 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 EFC49482.1 - 7.6e-07 29.8 0.7 0.045 14.5 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_11 PF08241.12 EFC49482.1 - 0.00014 22.4 0.0 0.078 13.6 0.0 2.9 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 EFC49482.1 - 0.00091 19.9 0.1 3.2 8.5 0.1 3.1 2 1 0 2 2 2 2 Methyltransferase domain ROQ_II PF18386.1 EFC49482.1 - 0.027 14.3 0.1 2.7 7.9 0.0 2.8 2 0 0 2 2 2 0 Roquin II domain Rad17 PF03215.15 EFC49483.1 - 0.0006 19.8 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 EFC49483.1 - 0.041 14.4 0.2 0.12 12.8 0.0 1.8 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 EFC49483.1 - 0.057 13.3 0.1 0.1 12.5 0.0 1.5 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 EFC49483.1 - 0.067 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 EFC49483.1 - 0.093 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC49483.1 - 0.093 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 EFC49483.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_7 PF12775.7 EFC49483.1 - 0.1 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RGS PF00615.19 EFC49485.1 - 1.4e-07 31.8 2.1 1.4e-07 31.8 2.1 2.2 2 0 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 EFC49485.1 - 0.00027 20.7 0.4 0.00066 19.4 0.4 1.6 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain Sterile PF03015.19 EFC49485.1 - 0.11 12.8 0.3 0.38 11.0 0.3 2.0 1 0 0 1 1 1 0 Male sterility protein LPD11 PF18824.1 EFC49485.1 - 0.14 12.3 0.2 0.32 11.1 0.2 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 11 Adeno_E3B PF03376.14 EFC49486.1 - 6.5 7.1 8.0 0.58 10.4 0.6 2.3 2 0 0 2 2 2 0 Adenovirus E3B protein Actin PF00022.19 EFC49487.1 - 4.1e-102 341.8 0.0 1.4e-100 336.8 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC49487.1 - 0.022 13.6 0.0 0.24 10.2 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein HlyIII PF03006.20 EFC49490.1 - 1.9e-33 116.1 17.1 2.7e-33 115.6 17.1 1.2 1 0 0 1 1 1 1 Haemolysin-III related Tat PF00539.18 EFC49490.1 - 2.1 8.6 3.6 3.6 7.8 3.6 1.3 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) DUF5344 PF17279.2 EFC49491.1 - 0.025 15.2 7.9 0.13 12.8 1.3 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Prefoldin PF02996.17 EFC49491.1 - 0.042 13.8 4.9 0.16 11.9 1.3 2.8 2 0 0 2 2 2 0 Prefoldin subunit TSC22 PF01166.18 EFC49491.1 - 0.15 12.4 0.3 0.15 12.4 0.3 3.3 4 0 0 4 4 4 0 TSC-22/dip/bun family Vps53_N PF04100.12 EFC49491.1 - 1.5 7.7 11.1 0.39 9.6 2.2 2.2 2 0 0 2 2 2 0 Vps53-like, N-terminal FlaC_arch PF05377.11 EFC49491.1 - 1.8 9.0 9.9 2.6 8.5 0.8 4.3 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) FlxA PF14282.6 EFC49491.1 - 3 7.9 13.8 3.4 7.7 1.4 4.4 4 0 0 4 4 4 0 FlxA-like protein MnmE_helical PF12631.7 EFC49491.1 - 6.3 6.9 9.4 4.5 7.4 2.1 2.3 2 0 0 2 2 2 0 MnmE helical domain DUF2408 PF10303.9 EFC49492.1 - 0.025 15.1 3.0 0.11 13.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) Adaptin_binding PF10199.9 EFC49492.1 - 0.055 14.1 2.8 0.59 10.8 0.0 2.8 2 2 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 GAS2 PF02187.17 EFC49492.1 - 0.13 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Growth-Arrest-Specific Protein 2 Domain Sec10 PF07393.11 EFC49492.1 - 0.75 8.1 6.3 0.025 13.0 0.6 1.5 2 0 0 2 2 2 0 Exocyst complex component Sec10 PPR_2 PF13041.6 EFC49493.1 - 1.8e-10 40.8 0.1 0.0045 17.2 0.0 3.6 2 1 1 3 3 3 3 PPR repeat family PPR_3 PF13812.6 EFC49493.1 - 1.9e-10 40.7 0.0 6.2e-07 29.4 0.0 2.1 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 EFC49493.1 - 5.4e-08 32.5 0.1 2.5e-07 30.3 0.1 1.9 1 1 1 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 EFC49493.1 - 1.2e-07 31.5 2.2 0.011 16.0 0.0 4.4 4 1 0 4 4 4 3 PPR repeat PPR_1 PF12854.7 EFC49493.1 - 0.0034 17.1 0.1 0.2 11.4 0.0 2.6 2 0 0 2 2 2 1 PPR repeat DSPc PF00782.20 EFC49494.1 - 5.5e-12 45.6 0.1 9.3e-12 44.9 0.1 1.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC49494.1 - 4e-07 29.8 0.1 5.3e-07 29.4 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC49494.1 - 3.3e-06 26.9 0.0 6.5e-06 25.9 0.0 1.4 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase3 PF13350.6 EFC49494.1 - 0.00071 19.6 0.0 0.00082 19.4 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 EFC49494.1 - 0.015 15.4 0.0 0.022 14.9 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 EFC49494.1 - 0.12 11.9 1.1 0.16 11.5 0.8 1.5 1 1 0 1 1 1 0 Tyrosine phosphatase family 2OG-FeII_Oxy_3 PF13640.6 EFC49496.1 - 3.1e-11 44.0 0.0 1.3e-10 42.0 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily F-box-like PF12937.7 EFC49496.1 - 0.0016 18.3 1.4 0.0047 16.8 0.2 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC49496.1 - 0.045 13.6 0.3 0.045 13.6 0.3 1.8 2 0 0 2 2 2 0 F-box domain RTX_C PF08339.10 EFC49496.1 - 0.1 12.6 4.8 1.4 9.0 1.6 2.5 2 0 0 2 2 2 0 RTX C-terminal domain PRANC PF09372.10 EFC49496.1 - 3.4 8.1 9.7 0.27 11.6 2.3 3.1 2 1 0 2 2 2 0 PRANC domain Orn_Arg_deC_N PF02784.16 EFC49497.1 - 1.1e-66 224.7 0.0 1.5e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 EFC49497.1 - 1.7e-11 44.2 0.0 2.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain MCM PF00493.23 EFC49498.1 - 5.3e-101 336.4 0.0 8.2e-101 335.8 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 EFC49498.1 - 1.5e-32 112.1 0.6 2.7e-32 111.3 0.6 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 EFC49498.1 - 8.6e-28 96.6 1.0 2.2e-27 95.3 1.0 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 EFC49498.1 - 9.9e-13 48.6 1.3 2.5e-12 47.3 0.6 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 EFC49498.1 - 2.3e-05 23.9 0.0 0.00033 20.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFC49498.1 - 0.0029 17.5 0.0 0.0069 16.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 EFC49498.1 - 0.028 14.4 0.0 0.15 12.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DnaJ PF00226.31 EFC49500.1 - 1.8e-15 56.8 1.6 1.8e-15 56.8 1.6 2.3 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 EFC49500.1 - 9.6e-06 25.3 0.1 2.7e-05 23.9 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NFACT-C PF11923.8 EFC49500.1 - 0.097 12.6 0.2 0.097 12.6 0.2 3.3 2 1 0 2 2 2 0 NFACT protein C-terminal domain Reprolysin_3 PF13582.6 EFC49500.1 - 0.12 12.8 2.6 0.64 10.5 0.2 2.3 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like NEMP PF10225.9 EFC49500.1 - 0.26 10.9 1.1 0.49 10.0 1.1 1.6 1 0 0 1 1 1 0 NEMP family SAD_SRA PF02182.17 EFC49500.1 - 1.8 8.3 6.7 0.31 10.7 2.8 1.8 2 0 0 2 2 2 0 SAD/SRA domain LSM PF01423.22 EFC49501.1 - 1.8e-17 62.7 0.3 2.5e-17 62.3 0.3 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFC49501.1 - 0.012 15.7 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Amino_oxidase PF01593.24 EFC49502.1 - 9e-38 130.7 0.0 7.5e-37 127.7 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Arabinose_trans PF04602.12 EFC49502.1 - 0.12 11.2 0.0 0.17 10.7 0.0 1.1 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein Peptidase_M76 PF09768.9 EFC49503.1 - 6.6e-32 110.6 0.7 7.9e-32 110.4 0.7 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 EFC49503.1 - 0.00038 20.3 0.0 0.00097 19.0 0.0 1.6 2 0 0 2 2 2 1 SprT-like family Tox-MPTase5 PF15641.6 EFC49503.1 - 0.014 15.4 0.1 0.033 14.2 0.1 1.6 2 0 0 2 2 2 0 Metallopeptidase toxin 5 MnmE_helical PF12631.7 EFC49503.1 - 0.053 13.7 0.0 0.07 13.3 0.0 1.1 1 0 0 1 1 1 0 MnmE helical domain Tox-MPTase3 PF15639.6 EFC49503.1 - 0.11 12.4 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Metallopeptidase toxin 3 Peptidase_M91 PF14891.6 EFC49503.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 Effector protein AA_permease_2 PF13520.6 EFC49504.1 - 1.7e-45 155.6 43.9 2.4e-45 155.1 43.9 1.2 1 0 0 1 1 1 1 Amino acid permease Pkinase PF00069.25 EFC49505.1 - 9.5e-41 139.9 0.0 1e-40 139.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49505.1 - 1.3e-39 136.0 0.0 1.4e-39 135.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC49505.1 - 0.00068 18.5 0.1 0.00094 18.1 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC49505.1 - 0.0024 17.8 0.0 0.0043 17.0 0.0 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family COMM_domain PF07258.14 EFC49506.1 - 3.4e-16 59.1 0.6 7e-16 58.1 0.6 1.6 1 0 0 1 1 1 1 COMM domain RCC1 PF00415.18 EFC49507.1 - 1e-10 42.1 2.8 0.00026 21.6 0.0 5.5 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat Antimicrobial19 PF08225.11 EFC49507.1 - 4.5e-05 22.9 1.0 0.03 13.9 0.0 3.4 3 0 0 3 3 3 2 Pseudin antimicrobial peptide RCC1_2 PF13540.6 EFC49507.1 - 0.0036 17.0 11.5 1.7 8.6 1.2 5.2 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RGS PF00615.19 EFC49508.1 - 0.00012 22.3 2.5 0.00012 22.3 2.5 3.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain Drf_FH3 PF06367.16 EFC49509.1 - 0.006 16.2 0.2 0.023 14.3 0.0 2.0 2 0 0 2 2 2 1 Diaphanous FH3 Domain DUF3783 PF12646.7 EFC49509.1 - 0.075 13.0 0.1 0.59 10.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) Condensin2nSMC PF12422.8 EFC49509.1 - 0.52 10.5 4.1 2.3 8.4 0.1 3.0 3 0 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit Rad52_Rad22 PF04098.15 EFC49510.1 - 0.0095 15.9 0.6 0.017 15.0 0.6 1.4 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein UPF0767 PF15990.5 EFC49510.1 - 0.24 11.6 1.9 0.43 10.7 0.1 2.1 2 0 0 2 2 2 0 UPF0767 family DUF4407 PF14362.6 EFC49510.1 - 2.4 7.4 6.3 0.37 10.1 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HSR PF03172.13 EFC49511.1 - 0.034 14.3 0.1 0.07 13.3 0.1 1.5 1 0 0 1 1 1 0 HSR domain HRG PF16954.5 EFC49511.1 - 0.13 12.7 0.0 0.13 12.7 0.0 3.8 4 1 0 4 4 4 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene AAA-ATPase_like PF09820.9 EFC49512.1 - 2e-58 198.0 0.8 5.7e-58 196.5 0.8 1.8 1 0 0 1 1 1 1 Predicted AAA-ATPase AAA_22 PF13401.6 EFC49512.1 - 0.14 12.5 0.0 1.4 9.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain NERD PF08378.11 EFC49512.1 - 0.15 12.5 4.8 0.11 12.9 0.5 3.0 3 1 0 3 3 3 0 Nuclease-related domain Ras PF00071.22 EFC49513.1 - 1.2e-13 51.0 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC49513.1 - 2.5e-08 33.6 0.0 4.7e-08 32.7 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC49513.1 - 3.6e-06 26.7 0.0 7.7e-06 25.6 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 EFC49513.1 - 0.00055 20.1 0.0 0.0015 18.8 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ribo_biogen_C PF04034.13 EFC49513.1 - 0.022 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein, C-terminal MMR_HSR1 PF01926.23 EFC49513.1 - 0.065 13.3 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase CRAL_TRIO PF00650.20 EFC49514.1 - 3.3e-38 130.9 0.0 4.9e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 EFC49514.1 - 3.1e-08 33.9 0.0 5.6e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 EFC49514.1 - 3.3e-07 30.4 0.1 8.5e-07 29.1 0.1 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain GCP_C_terminal PF04130.13 EFC49514.1 - 0.026 14.0 0.0 0.036 13.5 0.0 1.1 1 0 0 1 1 1 0 Gamma tubulin complex component C-terminal DUF4368 PF14287.6 EFC49514.1 - 0.054 13.8 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) TraF PF13728.6 EFC49515.1 - 0.033 14.0 2.7 3.4 7.4 0.0 2.2 2 0 0 2 2 2 0 F plasmid transfer operon protein bZIP_1 PF00170.21 EFC49515.1 - 0.14 12.2 31.8 1 9.5 1.2 5.8 4 3 3 7 7 7 0 bZIP transcription factor DUF2935 PF11155.8 EFC49515.1 - 0.17 12.3 0.1 0.17 12.3 0.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Tup_N PF08581.10 EFC49515.1 - 0.55 10.6 20.1 4 7.8 0.2 4.7 4 2 0 4 4 4 0 Tup N-terminal CLZ PF16526.5 EFC49515.1 - 1.6 9.2 24.1 0.44 10.9 2.6 3.2 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TPR_MLP1_2 PF07926.12 EFC49515.1 - 2.2 8.3 32.8 1.6 8.8 15.8 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 EFC49515.1 - 3.5 6.9 14.8 13 5.1 14.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 EFC49515.1 - 3.5 6.4 13.1 4.5 6.1 13.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein bZIP_2 PF07716.15 EFC49515.1 - 6.4 7.0 31.1 0.2 11.8 0.5 5.7 5 2 1 6 6 6 0 Basic region leucine zipper DUF1192 PF06698.11 EFC49515.1 - 7.9 6.6 9.1 21 5.3 0.0 4.3 4 1 1 5 5 5 0 Protein of unknown function (DUF1192) AAA_6 PF12774.7 EFC49517.1 - 4.3e-150 499.2 0.0 6.1e-148 492.1 0.0 3.6 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 EFC49517.1 - 2.9e-141 471.9 19.9 2.9e-141 471.9 19.9 3.9 5 0 0 5 5 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 EFC49517.1 - 1.6e-113 379.8 18.2 1.6e-113 379.8 18.2 6.5 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 EFC49517.1 - 1.9e-99 332.2 0.1 9.6e-99 329.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 EFC49517.1 - 1.2e-91 307.1 7.2 4.6e-91 305.2 0.1 3.4 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_9 PF12781.7 EFC49517.1 - 5.1e-79 264.4 10.9 5.1e-79 264.4 10.9 5.2 6 1 1 7 7 6 1 ATP-binding dynein motor region AAA_7 PF12775.7 EFC49517.1 - 2e-71 239.2 0.0 6e-64 214.9 0.0 3.9 3 0 0 3 3 3 3 P-loop containing dynein motor region MT PF12777.7 EFC49517.1 - 8.1e-69 232.3 15.9 8.1e-69 232.3 15.9 2.8 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor AAA_lid_11 PF18198.1 EFC49517.1 - 5.4e-53 179.2 0.0 3e-52 176.7 0.0 2.3 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 EFC49517.1 - 1.1e-40 138.4 0.9 7.8e-39 132.4 0.0 3.7 3 0 0 3 3 2 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 EFC49517.1 - 4.1e-22 78.7 0.0 1.7e-08 34.6 0.0 5.7 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 EFC49517.1 - 4.5e-21 75.3 0.6 3.1e-20 72.6 0.6 2.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 EFC49517.1 - 1.5e-17 63.6 1.1 1.1e-16 60.8 0.1 3.3 3 0 0 3 3 1 1 AAA+ lid domain AAA_22 PF13401.6 EFC49517.1 - 4e-08 33.6 0.7 0.36 11.1 0.0 5.6 4 0 0 4 4 4 2 AAA domain AAA_18 PF13238.6 EFC49517.1 - 3.1e-07 31.0 0.6 0.19 12.2 0.0 4.9 4 0 0 4 4 4 2 AAA domain AAA PF00004.29 EFC49517.1 - 2.1e-06 28.2 0.5 0.18 12.2 0.0 5.9 5 0 0 5 5 5 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC49517.1 - 0.00076 19.9 6.8 1 9.7 0.0 6.6 6 1 1 7 7 6 1 AAA ATPase domain RNA_helicase PF00910.22 EFC49517.1 - 0.0011 19.4 0.4 17 5.8 0.0 4.2 3 0 0 3 3 3 0 RNA helicase CbiA PF01656.23 EFC49517.1 - 0.0018 18.3 0.0 6.3 6.9 0.0 5.0 4 1 0 4 4 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 EFC49517.1 - 0.0045 16.7 0.1 0.67 9.6 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 EFC49517.1 - 0.017 15.3 0.0 12 6.1 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 EFC49517.1 - 0.025 14.9 0.2 27 5.1 0.0 4.0 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 EFC49517.1 - 0.037 13.7 0.1 0.37 10.5 0.0 2.7 3 0 0 3 3 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 EFC49517.1 - 0.038 13.7 0.0 7.6 6.2 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein PhoH PF02562.16 EFC49517.1 - 0.045 13.2 0.4 1.2 8.5 0.0 3.1 3 0 0 3 3 3 0 PhoH-like protein Sigma54_activ_2 PF14532.6 EFC49517.1 - 0.066 13.3 0.5 0.8 9.8 0.0 3.2 3 0 0 3 3 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFC49517.1 - 0.097 13.2 1.1 1 9.8 0.0 3.5 3 0 0 3 3 1 0 ABC transporter AAA_28 PF13521.6 EFC49517.1 - 0.46 10.7 5.6 2.3 8.4 0.0 3.9 4 0 0 4 4 2 0 AAA domain TAF6_C PF07571.13 EFC49518.1 - 4.3e-31 107.1 0.0 1.2e-30 105.7 0.0 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 EFC49518.1 - 3.2e-28 97.7 3.4 8.6e-28 96.3 0.5 2.6 3 0 0 3 3 3 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 EFC49518.1 - 1.2e-05 25.4 0.3 3.2e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 EFC49518.1 - 0.0012 19.3 0.2 0.0012 19.3 0.2 2.5 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Sigma70_ner PF04546.13 EFC49518.1 - 0.0069 16.3 0.3 0.0094 15.9 0.3 1.4 1 1 0 1 1 1 1 Sigma-70, non-essential region CBFD_NFYB_HMF PF00808.23 EFC49518.1 - 0.12 12.6 3.0 0.43 10.9 0.4 2.6 3 0 0 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DNA_methylase PF00145.17 EFC49519.1 - 6.1e-55 186.9 7.5 3e-46 158.3 0.0 3.8 3 0 0 3 3 3 2 C-5 cytosine-specific DNA methylase BAH PF01426.18 EFC49519.1 - 2.3e-16 59.7 1.7 6.7e-16 58.3 1.3 2.0 1 1 0 1 1 1 1 BAH domain DNMT1-RFD PF12047.8 EFC49519.1 - 1.1e-12 48.1 0.0 1.1e-12 48.1 0.0 3.3 3 1 0 3 3 3 1 Cytosine specific DNA methyltransferase replication foci domain DUF1152 PF06626.12 EFC49519.1 - 5.4e-05 22.6 0.0 0.00014 21.2 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1152) PEX11 PF05648.14 EFC49520.1 - 2.1e-28 99.3 1.5 8e-26 90.9 1.5 2.3 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) RNA_pol_Rpb1_5 PF04998.17 EFC49521.1 - 6e-87 291.4 0.9 1e-86 290.7 0.9 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 EFC49521.1 - 1.4e-82 277.5 2.7 2.5e-82 276.7 2.7 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 EFC49521.1 - 1.8e-69 233.2 0.2 4.8e-69 231.8 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 EFC49521.1 - 3.3e-42 144.1 0.3 1.1e-40 139.1 0.0 3.0 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 EFC49521.1 - 1.5e-29 102.1 0.1 6.6e-29 100.0 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 4 ApoA-II PF04711.13 EFC49523.1 - 0.021 15.0 0.1 0.077 13.2 0.1 2.0 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) Phi_1 PF04674.12 EFC49523.1 - 0.11 11.8 0.2 0.3 10.4 0.2 1.8 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region DUF3209 PF11483.8 EFC49523.1 - 0.15 12.6 8.0 0.14 12.7 1.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3209) DUF3290 PF11694.8 EFC49523.1 - 1.2 9.1 6.4 0.55 10.2 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Synaptobrevin PF00957.21 EFC49523.1 - 3.1 7.6 9.9 0.26 11.1 3.4 2.7 2 1 2 4 4 4 0 Synaptobrevin NYD-SP28_assoc PF14775.6 EFC49523.1 - 5.2 7.2 7.8 13 6.0 0.1 3.3 3 0 0 3 3 3 0 Sperm tail C-terminal domain Filament PF00038.21 EFC49524.1 - 0.0013 18.4 30.1 0.0013 18.4 30.1 2.8 1 1 1 2 2 2 1 Intermediate filament protein YtxH PF12732.7 EFC49524.1 - 2.8 8.5 17.2 6.5 7.4 0.7 4.8 2 2 0 3 3 3 0 YtxH-like protein Cullin_binding PF03556.15 EFC49524.1 - 3.1 8.3 7.0 1 9.8 3.3 2.1 2 1 0 2 2 2 0 Cullin binding DUF3450 PF11932.8 EFC49524.1 - 3.8 6.8 31.9 0.067 12.5 3.9 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF3450) HALZ PF02183.18 EFC49524.1 - 4.7 7.5 24.1 0.33 11.2 3.1 4.9 4 0 0 4 4 4 0 Homeobox associated leucine zipper Pyrophosphatase PF00719.19 EFC49525.1 - 4.4e-48 163.1 0.0 5.2e-48 162.9 0.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase InPase PF18823.1 EFC49525.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Inorganic Pyrophosphatase Ank_2 PF12796.7 EFC49526.1 - 1.3e-14 54.6 0.5 2.6e-07 31.1 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC49526.1 - 4.3e-11 43.1 0.4 0.049 14.2 0.0 4.5 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC49526.1 - 5.5e-10 39.3 0.2 0.064 13.6 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC49526.1 - 1.6e-06 28.3 0.3 0.72 10.4 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 EFC49526.1 - 5.1e-06 26.4 0.2 0.0068 16.8 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat DUF3447 PF11929.8 EFC49526.1 - 0.0032 17.4 0.1 0.2 11.7 0.0 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3447) Hydrolase_6 PF13344.6 EFC49527.1 - 3.8e-22 78.3 0.0 2.3e-21 75.8 0.0 2.2 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 EFC49527.1 - 7e-18 64.5 0.0 2e-17 63.0 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD_2 PF13419.6 EFC49527.1 - 0.0011 19.0 2.6 2.2 8.3 0.0 3.6 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 EFC49527.1 - 0.011 15.5 0.1 0.88 9.2 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 EFC49527.1 - 0.048 13.9 0.7 6.9 6.9 0.0 2.6 2 1 1 3 3 3 0 haloacid dehalogenase-like hydrolase SBP_bac_3 PF00497.20 EFC49528.1 - 3.1e-08 33.3 0.1 1.1e-07 31.5 0.0 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding proteins, family 3 DapH_N PF08503.10 EFC49528.1 - 0.21 11.8 1.2 6.9 7.0 0.0 3.2 3 0 0 3 3 3 0 Tetrahydrodipicolinate succinyltransferase N-terminal EF-G-binding_N PF07299.11 EFC49528.1 - 8.5 7.0 10.8 1.3 9.6 2.5 3.4 4 0 0 4 4 4 0 Elongation factor G-binding protein, N-terminal DnaJ PF00226.31 EFC49529.1 - 4.8e-13 49.0 2.1 1.4e-12 47.5 2.1 1.8 1 1 0 1 1 1 1 DnaJ domain LRR19-TM PF15176.6 EFC49529.1 - 0.099 12.6 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain FSAP_sig_propep PF03032.15 EFC49529.1 - 0.12 12.4 1.2 0.35 10.9 0.1 2.2 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide SecA_DEAD PF07517.14 EFC49529.1 - 0.21 10.8 0.8 0.35 10.1 0.8 1.4 1 1 0 1 1 1 0 SecA DEAD-like domain DUF4603 PF15376.6 EFC49529.1 - 0.23 8.8 0.8 0.25 8.7 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) DUF2816 PF10992.8 EFC49529.1 - 0.34 10.8 3.0 0.56 10.1 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2816) TauE PF01925.19 EFC49530.1 - 2.2e-32 112.6 20.5 9.2e-17 61.5 1.3 2.2 1 1 1 2 2 2 2 Sulfite exporter TauE/SafE MFS_1 PF07690.16 EFC49530.1 - 0.0016 17.4 23.7 0.39 9.6 10.4 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily S_4TM PF18159.1 EFC49530.1 - 0.0057 16.0 3.7 0.016 14.5 0.0 2.5 2 1 0 2 2 2 1 SMODS-associating 4TM effector domain Sugar_tr PF00083.24 EFC49530.1 - 0.0076 15.2 4.3 0.0076 15.2 4.3 2.8 3 1 0 3 3 3 1 Sugar (and other) transporter TssO PF17561.2 EFC49530.1 - 0.01 15.9 2.7 0.074 13.2 0.2 2.4 1 1 1 2 2 2 0 Type VI secretion system, TssO 60KD_IMP PF02096.20 EFC49530.1 - 0.023 14.6 0.1 0.096 12.6 0.1 2.1 1 1 0 1 1 1 0 60Kd inner membrane protein Dpy19 PF10034.9 EFC49530.1 - 0.032 12.5 0.0 0.051 11.8 0.0 1.3 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF3487 PF11990.8 EFC49530.1 - 0.032 14.1 0.3 0.032 14.1 0.3 3.6 3 3 2 5 5 5 0 Protein of unknown function (DUF3487) TMEMspv1-c74-12 PF11044.8 EFC49530.1 - 0.064 13.2 1.9 6.9 6.7 0.4 2.9 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Consortin_C PF15281.6 EFC49530.1 - 0.072 13.1 0.0 8.7 6.4 0.0 2.5 2 0 0 2 2 2 0 Consortin C-terminus Phage_Gp23 PF10669.9 EFC49530.1 - 0.076 13.3 1.5 0.08 13.3 0.1 1.7 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Pex24p PF06398.11 EFC49530.1 - 0.16 10.9 0.1 0.16 10.9 0.1 1.8 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin DUF202 PF02656.15 EFC49530.1 - 0.23 11.9 7.4 8.3 6.9 1.1 4.5 3 2 0 3 3 3 0 Domain of unknown function (DUF202) DUF1647 PF07801.11 EFC49531.1 - 9.4e-05 22.2 1.5 0.0018 18.0 0.0 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF1647) Aa_trans PF01490.18 EFC49532.1 - 6.9e-63 212.8 35.1 1.5e-46 159.0 31.5 2.0 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Seipin PF06775.14 EFC49533.1 - 1e-23 84.5 4.3 1.9e-23 83.6 4.3 1.4 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Cpn60_TCP1 PF00118.24 EFC49534.1 - 5.5e-148 493.6 13.3 6.3e-148 493.4 13.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5442 PF17514.2 EFC49534.1 - 0.018 15.2 2.7 0.018 15.2 0.8 2.0 3 0 0 3 3 3 0 Family of unknown function (DUF5442) SNF2_N PF00176.23 EFC49535.1 - 8.4e-70 235.2 2.8 3e-69 233.4 2.8 2.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC49535.1 - 9.3e-21 74.3 1.2 4e-20 72.2 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 EFC49535.1 - 5e-08 33.1 10.6 5e-08 33.1 10.6 2.8 2 0 0 2 2 2 1 HSA AAA_25 PF13481.6 EFC49535.1 - 0.039 13.5 0.5 0.088 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain Myb_DNA-binding PF00249.31 EFC49536.1 - 0.0012 19.0 0.7 0.0036 17.5 0.7 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC49536.1 - 0.0071 16.6 0.2 0.022 15.0 0.2 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 EFC49536.1 - 0.0091 16.4 0.1 0.042 14.2 0.1 2.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF2497 PF10691.9 EFC49536.1 - 2.4 8.6 5.0 1.7 9.1 0.1 3.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2497) LRR_4 PF12799.7 EFC49539.1 - 2.9e-22 78.4 65.0 1e-08 35.3 3.2 6.1 1 1 7 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49539.1 - 2.9e-08 33.3 37.4 2.2e-07 30.5 9.4 5.6 1 1 5 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 EFC49539.1 - 4.2e-08 32.9 22.5 0.013 15.0 7.4 4.6 2 1 2 4 4 4 4 Leucine-rich repeat DUF840 PF05801.11 EFC49539.1 - 0.004 17.2 1.8 0.85 9.7 0.1 2.8 2 0 0 2 2 2 2 Lagovirus protein of unknown function (DUF840) DUF711 PF05167.12 EFC49540.1 - 0.1 11.5 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) zf-CCCH_4 PF18044.1 EFC49541.1 - 2.7e-07 30.2 5.8 3.9e-07 29.7 5.8 1.2 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 EFC49541.1 - 0.0004 20.3 10.8 0.0006 19.8 10.8 1.3 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 EFC49541.1 - 0.0029 17.5 3.9 0.0047 16.8 3.9 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 EFC49541.1 - 0.037 14.7 3.1 0.037 14.7 3.1 1.9 1 1 1 2 2 2 0 Torus domain Cwf_Cwc_15 PF04889.12 EFC49541.1 - 1.1 8.9 17.5 1.5 8.5 17.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 EFC49541.1 - 1.4 8.3 20.9 1.6 8.1 20.9 1.0 1 0 0 1 1 1 0 SDA1 TPX2_importin PF12214.8 EFC49542.1 - 2e-17 63.9 58.6 1.3e-11 45.0 19.6 6.4 3 2 2 5 5 5 4 Cell cycle regulated microtubule associated protein MutS_V PF00488.21 EFC49544.1 - 1.6e-69 233.7 0.3 3.4e-69 232.6 0.3 1.6 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFC49544.1 - 1.9e-27 96.8 3.8 1.9e-27 96.8 3.8 1.8 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 EFC49544.1 - 3.8e-13 49.6 2.4 1.4e-12 47.8 2.4 2.1 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 EFC49544.1 - 7e-06 26.4 0.2 2.3e-05 24.7 0.2 1.9 1 0 0 1 1 1 1 MutS domain II AAA_14 PF13173.6 EFC49544.1 - 0.0018 18.3 0.3 0.012 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain HTH_11 PF08279.12 EFC49544.1 - 0.0032 17.4 0.2 0.018 15.0 0.1 2.3 2 0 0 2 2 2 1 HTH domain Dynamin_N PF00350.23 EFC49544.1 - 0.016 15.3 1.3 7 6.7 0.1 3.2 2 1 0 2 2 2 0 Dynamin family AAA_30 PF13604.6 EFC49544.1 - 0.078 12.7 0.0 0.45 10.2 0.0 2.2 3 0 0 3 3 3 0 AAA domain AAA_27 PF13514.6 EFC49544.1 - 0.084 12.5 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Cpn60_TCP1 PF00118.24 EFC49545.1 - 1.4e-33 116.3 4.0 2.5e-33 115.5 4.0 1.3 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PIP5K PF01504.18 EFC49545.1 - 5.7e-32 111.0 3.3 1.6e-26 93.2 0.7 3.5 3 2 1 4 4 4 2 Phosphatidylinositol-4-phosphate 5-Kinase FYVE PF01363.21 EFC49545.1 - 3.3e-18 65.6 7.7 3.3e-18 65.6 7.7 2.0 2 0 0 2 2 2 1 FYVE zinc finger baeRF_family5 PF18846.1 EFC49545.1 - 0.016 15.4 0.0 0.065 13.4 0.0 2.1 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 FYVE_2 PF02318.16 EFC49545.1 - 0.5 10.6 9.0 0.18 12.0 5.3 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger IBR PF01485.21 EFC49545.1 - 1 9.6 10.4 0.5 10.6 6.4 2.6 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain tRNA_Me_trans PF03054.16 EFC49546.1 - 1.6e-109 366.0 0.0 1.9e-109 365.8 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 EFC49546.1 - 0.0001 21.6 0.0 0.0003 20.0 0.0 1.7 2 0 0 2 2 2 1 NAD synthase Asn_synthase PF00733.21 EFC49546.1 - 0.0057 16.4 0.0 0.0074 16.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase ThiI PF02568.14 EFC49546.1 - 0.051 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 EFC49546.1 - 0.13 12.0 0.0 1 9.1 0.0 2.1 2 0 0 2 2 2 0 PP-loop family WD40 PF00400.32 EFC49547.1 - 3.8e-18 65.5 16.4 1.4e-05 25.7 0.0 6.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49547.1 - 2.1e-07 31.2 0.6 0.033 14.5 0.0 5.0 2 1 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC49547.1 - 0.0013 17.7 1.8 0.0082 15.1 0.3 2.4 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 EFC49547.1 - 0.0058 15.7 1.6 0.011 14.8 0.6 1.9 1 1 1 2 2 2 1 Coatomer WD associated region Frtz PF11768.8 EFC49547.1 - 0.03 12.6 0.1 1.7 6.9 0.0 2.4 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Peptidase_M24 PF00557.24 EFC49548.1 - 1.3e-51 175.3 0.1 2e-51 174.7 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 EFC49548.1 - 1.6e-24 86.0 0.0 3.3e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Ribosomal_L23eN PF03939.13 EFC49549.1 - 3.6e-12 46.3 8.9 3.6e-12 46.3 8.9 2.5 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 EFC49549.1 - 1.7e-09 37.9 1.4 1.7e-09 37.9 1.4 2.3 2 1 0 2 2 2 1 Ribosomal protein L23 DUF1140 PF06600.11 EFC49549.1 - 0.36 11.3 4.3 0.15 12.5 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1140) LSM PF01423.22 EFC49550.1 - 5.7e-19 67.6 0.0 6.8e-19 67.3 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFC49550.1 - 0.0037 17.4 0.0 0.0048 17.0 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain WD40 PF00400.32 EFC49551.1 - 4.7e-09 36.7 8.9 0.00023 21.9 0.2 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Arm PF00514.23 EFC49552.1 - 0.084 12.9 0.1 10 6.3 0.0 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat NRIP1_repr_4 PF15690.5 EFC49552.1 - 0.086 12.1 3.1 4.4 6.5 0.1 2.4 2 0 0 2 2 2 0 Nuclear receptor-interacting protein 1 repression 4 Ank_2 PF12796.7 EFC49553.1 - 3.9e-12 46.6 1.6 7.5e-09 36.1 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 EFC49553.1 - 4.2e-11 42.9 1.0 9.7e-06 25.8 0.0 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 EFC49553.1 - 1.8e-10 41.2 0.8 3e-05 24.5 0.1 4.1 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC49553.1 - 4e-09 36.5 0.1 0.015 15.7 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat TIG PF01833.24 EFC49553.1 - 5.8e-09 35.9 0.2 4.8e-08 33.0 0.0 2.8 2 0 0 2 2 2 1 IPT/TIG domain Ank_3 PF13606.6 EFC49553.1 - 1.4e-08 34.3 0.2 0.0087 16.5 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat DUF3860 PF12976.7 EFC49553.1 - 0.053 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) DUF2206 PF09971.9 EFC49553.1 - 0.26 10.0 6.6 0.45 9.2 6.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Actin PF00022.19 EFC49554.1 - 1.8e-116 389.1 0.0 6.8e-116 387.2 0.0 1.7 1 1 0 1 1 1 1 Actin Put_Phosphatase PF06888.12 EFC49555.1 - 0.071 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Putative Phosphatase CENP-F_leu_zip PF10473.9 EFC49555.1 - 0.077 13.0 1.8 0.13 12.3 1.8 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TRAF_BIRC3_bd PF16673.5 EFC49555.1 - 0.08 12.7 1.7 0.23 11.3 1.7 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain Atg14 PF10186.9 EFC49555.1 - 0.086 11.9 1.0 0.16 11.0 1.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_1 PF00170.21 EFC49555.1 - 0.092 12.9 2.0 0.21 11.7 2.0 1.6 1 0 0 1 1 1 0 bZIP transcription factor Ras PF00071.22 EFC49556.1 - 1.3e-08 34.6 0.8 1.8e-08 34.2 0.8 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49556.1 - 0.00059 20.0 0.0 0.0017 18.6 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 EFC49556.1 - 0.05 13.9 0.0 0.082 13.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain Tnp_22_trimer PF17489.2 EFC49556.1 - 1 9.4 4.2 7.4 6.6 4.2 2.4 1 1 0 1 1 1 0 L1 transposable element trimerization domain DUF4718 PF15842.5 EFC49557.1 - 4.2 7.1 15.3 3.1 7.6 5.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) WD40 PF00400.32 EFC49558.1 - 2e-22 79.1 15.6 1.3e-06 29.0 0.1 6.7 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49558.1 - 3.3e-09 36.9 0.0 0.12 12.7 0.0 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC49558.1 - 0.063 12.2 1.1 1.5 7.7 0.0 2.8 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 EFC49558.1 - 0.08 11.5 0.0 2.2 6.7 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain ParcG PF10274.9 EFC49559.1 - 0.0013 18.8 2.7 1.4 9.0 0.0 2.8 2 0 0 2 2 2 2 Parkin co-regulated protein Chromosome_seg PF13889.6 EFC49559.1 - 0.21 11.8 1.8 1.1 9.5 0.3 2.8 3 0 0 3 3 3 0 Chromosome segregation during meiosis MCC-bdg_PDZ PF10506.9 EFC49559.1 - 0.25 11.4 5.9 0.69 10.0 5.9 1.8 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome ERAP1_C PF11838.8 EFC49560.1 - 0.0023 17.5 0.4 0.012 15.2 0.2 2.3 1 1 1 2 2 2 1 ERAP1-like C-terminal domain SPG48 PF14764.6 EFC49560.1 - 0.0045 17.5 0.5 0.012 16.1 0.1 2.0 2 0 0 2 2 2 1 AP-5 complex subunit, vesicle trafficking DUF1803 PF08820.10 EFC49560.1 - 0.0051 16.8 0.4 1.8 8.6 0.1 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1803) eIF3m_C_helix PF18005.1 EFC49560.1 - 0.011 15.4 1.1 0.02 14.6 1.1 1.5 1 0 0 1 1 1 0 eIF3 subunit M, C-terminal helix PCI PF01399.27 EFC49560.1 - 0.043 14.3 3.1 0.13 12.8 0.9 2.8 2 1 0 2 2 2 0 PCI domain tRNA_U5-meth_tr PF05958.11 EFC49561.1 - 1.4e-20 73.6 0.3 3.4e-20 72.3 0.1 1.7 2 0 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 EFC49561.1 - 4.2e-10 39.6 0.2 1.7e-09 37.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 EFC49561.1 - 1.4e-07 31.3 0.1 3e-07 30.1 0.1 1.6 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 EFC49561.1 - 2.8e-07 31.1 0.0 9.5e-07 29.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 EFC49561.1 - 3e-06 26.8 0.4 3e-06 26.8 0.4 2.1 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 EFC49561.1 - 7e-05 22.4 0.1 0.0002 20.9 0.1 1.8 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 EFC49561.1 - 8.4e-05 22.3 0.1 0.00032 20.4 0.0 2.0 2 0 0 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_32 PF13679.6 EFC49561.1 - 0.00028 20.9 6.4 0.00032 20.7 0.1 2.5 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 EFC49561.1 - 0.00078 19.3 0.2 0.0017 18.2 0.2 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SR-25 PF10500.9 EFC49561.1 - 0.00085 19.0 7.2 0.0015 18.2 7.2 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Ubie_methyltran PF01209.18 EFC49561.1 - 0.001 18.4 0.2 0.0023 17.3 0.2 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 EFC49561.1 - 0.0016 19.0 0.1 0.0044 17.6 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 EFC49561.1 - 0.0036 16.7 0.3 0.0036 16.7 0.3 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) TPMT PF05724.11 EFC49561.1 - 0.035 13.8 0.0 0.09 12.4 0.0 1.6 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Methyltrans_SAM PF10672.9 EFC49561.1 - 0.049 12.8 0.0 0.078 12.1 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase GAGA_bind PF06217.12 EFC49561.1 - 0.081 13.2 6.2 0.16 12.2 6.2 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family TPR_11 PF13414.6 EFC49562.1 - 4.5e-10 39.0 0.7 8.2e-06 25.4 0.8 2.5 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 EFC49562.1 - 7e-08 32.3 0.4 0.00064 19.9 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49562.1 - 8.4e-07 28.6 0.1 0.0023 17.9 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49562.1 - 2.8e-06 26.9 3.0 0.003 17.3 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat BTB PF00651.31 EFC49562.1 - 0.00051 20.3 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain TPR_16 PF13432.6 EFC49562.1 - 0.02 15.5 0.0 0.047 14.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Band_7 PF01145.25 EFC49562.1 - 0.045 13.7 0.2 0.08 13.0 0.2 1.4 1 0 0 1 1 1 0 SPFH domain / Band 7 family TPR_19 PF14559.6 EFC49562.1 - 0.046 14.2 0.0 0.13 12.8 0.0 1.7 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC49562.1 - 0.2 12.6 0.0 0.47 11.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC49562.1 - 0.2 11.8 0.0 1.8 8.8 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Spore_III_AB PF09548.10 EFC49562.1 - 0.45 10.6 2.2 1.1 9.4 2.2 1.6 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) S_100 PF01023.19 EFC49562.1 - 8.2 6.2 7.8 3.8 7.3 1.3 2.6 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain DUF1319 PF07028.11 EFC49562.1 - 8.3 6.7 9.1 9.5 6.5 3.6 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1319) Actin PF00022.19 EFC49563.1 - 3.9e-66 223.4 0.0 6.9e-64 215.9 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC49563.1 - 0.02 13.7 0.0 0.04 12.7 0.0 1.4 1 0 0 1 1 1 0 MreB/Mbl protein CENP_C_N PF15622.6 EFC49563.1 - 0.085 12.3 0.2 0.23 10.9 0.1 1.6 2 0 0 2 2 2 0 Kinetochore assembly subunit CENP-C N-terminal Hemocyanin_N PF03722.14 EFC49565.1 - 0.038 14.5 1.7 0.12 12.9 1.7 1.9 1 0 0 1 1 1 0 Hemocyanin, all-alpha domain Ino80_Iec3 PF14612.6 EFC49566.1 - 1.1 9.9 6.8 0.31 11.7 2.5 2.2 2 2 0 2 2 2 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling OTU PF02338.19 EFC49567.1 - 5.3e-12 46.3 0.2 5.3e-12 46.3 0.2 1.9 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 EFC49567.1 - 6e-05 22.6 2.4 0.00075 19.0 0.2 2.5 2 1 0 2 2 2 1 Peptidase C65 Otubain Acyltransf_C PF16076.5 EFC49567.1 - 5.7 7.1 7.7 6.1 7.0 0.2 3.1 3 1 0 3 3 3 0 Acyltransferase C-terminus RGS PF00615.19 EFC49568.1 - 3e-08 33.9 9.3 2.2e-07 31.1 1.5 2.7 2 1 1 3 3 3 2 Regulator of G protein signaling domain Proho_convert PF12177.8 EFC49568.1 - 0.17 11.9 1.3 11 6.1 0.1 2.6 2 0 0 2 2 2 0 Prohormone convertase enzyme HNF-1_N PF04814.13 EFC49568.1 - 1.4 9.5 5.0 0.2 12.3 0.2 2.0 2 1 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus RGS PF00615.19 EFC49569.1 - 0.00058 20.1 2.1 0.00094 19.4 0.7 2.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF966 PF06136.13 EFC49570.1 - 0.051 13.3 6.1 0.09 12.5 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Cystatin PF00031.21 EFC49571.1 - 1.1e-12 48.1 1.5 2.3e-05 24.6 0.2 2.3 2 0 0 2 2 2 2 Cystatin domain SQAPI PF16845.5 EFC49571.1 - 2.5e-08 34.1 1.2 0.0033 17.7 0.0 2.4 2 0 0 2 2 2 2 Aspartic acid proteinase inhibitor Acetate_kinase PF00871.17 EFC49571.1 - 0.012 14.3 4.9 0.015 14.0 1.4 2.0 1 1 1 2 2 2 0 Acetokinase family ATP-cone PF03477.16 EFC49571.1 - 0.12 13.0 4.1 0.35 11.4 0.6 2.3 1 1 0 2 2 2 0 ATP cone domain Pfg27 PF09216.10 EFC49571.1 - 0.18 11.6 7.6 0.081 12.7 2.0 2.1 2 0 0 2 2 2 0 Pfg27 Cnd1 PF12717.7 EFC49572.1 - 2.5e-41 141.4 18.3 2.6e-39 134.9 1.0 5.2 4 1 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 EFC49572.1 - 3e-25 89.0 4.2 3e-25 89.0 4.2 3.9 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 EFC49572.1 - 1.6e-09 37.2 1.0 0.86 10.0 0.0 7.6 6 0 0 6 6 6 2 HEAT repeat Cohesin_HEAT PF12765.7 EFC49572.1 - 0.0013 19.0 3.0 0.005 17.1 0.0 3.5 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion Nipped-B_C PF12830.7 EFC49572.1 - 0.2 11.6 11.5 0.018 15.0 1.5 4.3 5 2 0 5 5 5 0 Sister chromatid cohesion C-terminus DUF365 PF04033.12 EFC49572.1 - 0.97 9.7 9.5 1.2 9.5 1.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF365) DUF4763 PF15960.5 EFC49573.1 - 0.022 14.1 1.1 0.031 13.6 1.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Complex1_LYR PF05347.15 EFC49573.1 - 0.037 14.1 0.3 0.061 13.4 0.3 1.3 1 0 0 1 1 1 0 Complex 1 protein (LYR family) DUF5625 PF18539.1 EFC49573.1 - 0.039 14.2 0.2 0.042 14.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5625) AAA_lid_5 PF17865.1 EFC49574.1 - 0.089 12.9 0.3 0.31 11.1 0.1 2.0 2 0 0 2 2 2 0 Midasin AAA lid domain BK_channel_a PF03493.18 EFC49577.1 - 1.2e-12 47.9 0.0 5.2e-09 36.2 0.0 2.9 2 0 0 2 2 2 2 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.18 EFC49577.1 - 0.0031 17.7 0.1 0.67 10.2 0.1 3.1 2 0 0 2 2 2 2 TrkA-N domain Ion_trans_2 PF07885.16 EFC49578.1 - 1.6e-11 44.0 9.1 1.6e-11 44.0 9.1 2.6 2 0 0 2 2 2 1 Ion channel BK_channel_a PF03493.18 EFC49578.1 - 2.2e-07 31.0 0.1 6.2e-07 29.5 0.1 1.8 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.18 EFC49578.1 - 1.1e-06 28.9 0.0 6.1e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 TrkA-N domain DUF2214 PF09980.9 EFC49578.1 - 0.056 13.3 0.9 0.16 11.8 0.9 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) Rsbr_N PF08678.10 EFC49578.1 - 0.07 13.2 1.7 0.12 12.4 0.3 2.2 2 0 0 2 2 2 0 Rsbr N terminal NDK PF00334.19 EFC49579.1 - 1.2e-41 141.8 0.0 1.9e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Dpy-30 PF05186.13 EFC49579.1 - 4.5e-12 45.5 0.2 8.5e-12 44.6 0.2 1.5 1 0 0 1 1 1 1 Dpy-30 motif Ribonuclease_T2 PF00445.18 EFC49580.1 - 1.5e-07 31.9 3.9 2.1e-06 28.1 3.9 2.6 1 1 0 1 1 1 1 Ribonuclease T2 family DUF3833 PF12915.7 EFC49581.1 - 0.016 14.8 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) Aminotran_1_2 PF00155.21 EFC49582.1 - 1.5e-57 195.5 0.0 1.7e-57 195.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 EFC49582.1 - 4.2e-06 26.3 0.0 5.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 EFC49582.1 - 0.0002 20.4 0.0 0.00042 19.4 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class-V OKR_DC_1 PF01276.20 EFC49582.1 - 0.0012 17.6 0.1 0.0019 17.0 0.1 1.1 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Cys_Met_Meta_PP PF01053.20 EFC49582.1 - 0.0038 15.8 0.0 0.0068 15.0 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 EFC49582.1 - 0.0073 15.7 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Acetate_kinase PF00871.17 EFC49582.1 - 0.11 11.2 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Acetokinase family Pyridoxal_deC PF00282.19 EFC49583.1 - 8.6e-18 64.2 0.0 5.4e-17 61.6 0.0 2.0 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 EFC49583.1 - 0.00037 19.8 0.0 0.001 18.3 0.0 1.7 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 EFC49583.1 - 0.0013 18.1 0.1 0.0057 16.0 0.0 2.0 2 1 1 3 3 3 1 DegT/DnrJ/EryC1/StrS aminotransferase family WD40 PF00400.32 EFC49584.1 - 6.1e-10 39.5 0.2 0.18 12.8 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat TAN PF11640.8 EFC49585.1 - 0.0027 17.8 3.5 0.0032 17.6 0.9 2.3 1 1 2 3 3 3 3 Telomere-length maintenance and DNA damage repair PI3_PI4_kinase PF00454.27 EFC49586.1 - 2.3e-60 204.5 0.1 3.1e-59 200.8 0.0 2.8 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 EFC49586.1 - 3.3e-11 43.0 8.6 3.3e-11 43.0 8.6 1.8 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 EFC49586.1 - 6.2e-10 38.7 0.0 2.1e-09 37.0 0.0 2.0 1 0 0 1 1 1 1 FATC domain DUF5365 PF17326.2 EFC49586.1 - 0.043 14.2 1.4 0.28 11.6 0.4 3.1 2 0 0 2 2 2 0 Family of unknown function (DUF5365) F-box-like PF12937.7 EFC49588.1 - 0.0058 16.5 0.1 0.015 15.2 0.1 1.7 1 0 0 1 1 1 1 F-box-like RHH_3 PF12651.7 EFC49588.1 - 0.01 15.8 0.1 0.031 14.3 0.1 1.8 1 0 0 1 1 1 0 Ribbon-helix-helix domain F-box_4 PF15966.5 EFC49588.1 - 0.031 14.1 0.2 12 5.9 0.0 2.8 2 0 0 2 2 2 0 F-box DUF5491 PF17595.2 EFC49588.1 - 0.054 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5491) LRR_6 PF13516.6 EFC49588.1 - 0.062 13.4 7.6 0.99 9.6 0.4 4.7 4 0 0 4 4 4 0 Leucine Rich repeat PDGF_N PF04692.13 EFC49588.1 - 4.3 8.2 5.4 6.9 7.5 0.2 2.8 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region D-ser_dehydrat PF14031.6 EFC49589.1 - 3e-19 69.5 0.0 5.5e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 EFC49589.1 - 2.1e-15 57.0 0.0 3e-15 56.5 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF1318 PF07027.12 EFC49589.1 - 0.087 13.3 0.4 0.64 10.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1318) zf-B_box PF00643.24 EFC49590.1 - 6.7e-06 26.2 6.9 1.1e-05 25.4 6.9 1.4 1 0 0 1 1 1 1 B-box zinc finger TcpS PF17456.2 EFC49590.1 - 0.071 13.2 2.6 0.36 10.9 2.3 2.2 1 1 0 1 1 1 0 Toxin-coregulated pilus protein S Tox-ODYAM1 PF15642.6 EFC49590.1 - 0.24 10.3 3.4 0.16 10.9 1.5 1.6 1 1 0 1 1 1 0 Toxin in Odyssella and Amoebophilus zf-UBR PF02207.20 EFC49590.1 - 1.3 9.2 7.5 3.1 8.0 7.5 1.6 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) zf-C2HC_2 PF13913.6 EFC49591.1 - 8.9e-10 38.2 6.3 0.00015 21.6 1.2 2.3 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-Di19 PF05605.12 EFC49591.1 - 0.03 14.6 5.3 0.093 13.0 1.3 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 EFC49591.1 - 0.031 14.2 5.1 0.58 10.1 0.4 2.5 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 EFC49591.1 - 0.13 12.4 3.8 1.8 8.7 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger domain DZR PF12773.7 EFC49591.1 - 0.16 12.0 2.3 5.6 7.1 0.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-C2H2_4 PF13894.6 EFC49591.1 - 0.51 11.3 8.5 1.6 9.8 1.6 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Cys_rich_CPXG PF14255.6 EFC49591.1 - 1.3 9.0 3.4 13 5.7 0.4 2.6 2 0 0 2 2 2 0 Cysteine-rich CPXCG SBP PF03110.14 EFC49591.1 - 3 8.2 5.7 0.3 11.4 0.5 2.0 2 0 0 2 2 2 0 SBP domain Fic PF02661.18 EFC49592.1 - 5.3e-15 56.1 0.0 2.2e-14 54.1 0.0 2.0 1 1 1 2 2 2 1 Fic/DOC family BROMI PF14961.6 EFC49593.1 - 3.8e-13 47.9 12.3 6.1e-08 30.6 4.2 2.4 2 0 0 2 2 2 2 Broad-minded protein TIP120 PF08623.10 EFC49593.1 - 1.7e-05 24.6 1.7 0.0084 15.9 0.1 2.7 3 0 0 3 3 3 2 TATA-binding protein interacting (TIP20) Vps39_2 PF10367.9 EFC49594.1 - 1.6e-23 83.3 2.7 1.6e-23 83.3 2.7 3.1 3 1 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 EFC49594.1 - 1.6e-07 31.3 4.4 7e-07 29.2 4.4 2.2 1 1 0 1 1 1 1 Region in Clathrin and VPS CNH PF00780.22 EFC49594.1 - 9.9e-06 25.4 0.1 0.00029 20.5 0.1 2.6 1 1 0 1 1 1 1 CNH domain Vps39_1 PF10366.9 EFC49594.1 - 0.00058 20.1 3.9 0.16 12.3 1.7 3.0 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 Nrap_D5 PF17406.2 EFC49594.1 - 0.15 11.8 0.5 2.4 7.9 0.0 2.7 3 0 0 3 3 3 0 Nrap protein PAP/OAS1-like domain 5 SNRNP27 PF08648.12 EFC49595.1 - 2.1e-09 37.3 0.1 7.6e-09 35.5 0.1 1.9 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins CLASP_N PF12348.8 EFC49596.1 - 8.5e-12 45.1 22.3 8.5e-06 25.5 1.0 4.9 5 0 0 5 5 5 3 CLASP N terminal ParcG PF10274.9 EFC49596.1 - 1.6e-08 34.9 4.0 2.6e-06 27.7 0.4 4.0 3 0 0 3 3 3 1 Parkin co-regulated protein HEAT PF02985.22 EFC49596.1 - 8.7e-06 25.6 5.6 0.064 13.5 0.3 6.1 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 EFC49596.1 - 3.6e-05 24.2 0.4 1.3 9.6 0.0 5.0 4 1 1 5 5 5 2 HEAT-like repeat Cnd1 PF12717.7 EFC49596.1 - 0.00017 21.7 0.9 0.00017 21.7 0.9 8.0 7 1 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC49596.1 - 0.0004 20.7 0.0 2.7 8.5 0.0 4.6 3 1 0 3 3 3 1 HEAT repeats Vac14_Fab1_bd PF12755.7 EFC49596.1 - 0.0031 18.1 7.7 15 6.2 0.0 5.9 5 1 1 6 6 6 2 Vacuolar 14 Fab1-binding region Xpo1 PF08389.12 EFC49596.1 - 0.24 11.5 19.0 0.37 10.8 0.3 6.6 6 2 2 8 8 8 0 Exportin 1-like protein DUF647 PF04884.14 EFC49597.1 - 7.4e-63 212.4 5.6 8.7e-63 212.2 5.6 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis UxuA PF03786.13 EFC49599.1 - 0.15 10.9 0.0 12 4.7 0.0 2.3 2 0 0 2 2 2 0 D-mannonate dehydratase (UxuA) WD40 PF00400.32 EFC49600.1 - 1.5e-10 41.5 0.1 0.014 16.3 0.0 4.0 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49600.1 - 0.0001 22.6 0.0 0.065 13.5 0.0 4.3 4 2 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC49600.1 - 0.064 13.1 0.9 0.59 10.0 0.5 2.4 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Rep_fac-A_C PF08646.10 EFC49601.1 - 7.6e-28 97.1 5.1 1.1e-26 93.3 4.5 2.3 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 EFC49601.1 - 2.4e-27 94.7 6.4 4.5e-25 87.4 0.9 2.9 3 0 0 3 3 3 2 Replication protein A OB domain tRNA_anti-codon PF01336.25 EFC49601.1 - 1.8e-10 40.6 1.5 3.8e-08 33.2 0.0 3.5 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain DUF223 PF02721.14 EFC49601.1 - 0.0066 16.7 0.5 0.041 14.2 0.0 2.7 2 1 1 3 3 3 1 Domain of unknown function DUF223 Pox_A12 PF04651.13 EFC49601.1 - 0.044 13.8 5.9 0.048 13.7 3.4 2.4 2 0 0 2 2 2 0 Poxvirus A12 protein zf-CHC2 PF01807.20 EFC49601.1 - 0.71 9.7 3.6 0.27 11.1 0.5 1.9 2 0 0 2 2 2 0 CHC2 zinc finger Mog1 PF04603.12 EFC49602.1 - 2.5e-30 105.6 0.0 3.2e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein RRM_1 PF00076.22 EFC49603.1 - 6.2e-37 125.3 0.0 2.8e-21 75.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC49603.1 - 2.3e-07 30.4 0.0 0.00061 19.4 0.0 2.2 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC49603.1 - 2.1e-05 24.6 0.0 0.082 13.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 EFC49603.1 - 0.00042 20.6 0.1 0.23 11.7 0.0 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 EFC49603.1 - 0.056 13.3 0.0 5.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 EFC49603.1 - 0.11 12.6 0.1 12 6.0 0.0 2.4 2 0 0 2 2 2 0 Limkain b1 OB_RNB PF08206.11 EFC49603.1 - 0.13 11.9 0.1 4.6 7.0 0.1 2.3 2 0 0 2 2 2 0 Ribonuclease B OB domain EF-hand_1 PF00036.32 EFC49604.1 - 7.1e-15 53.4 9.2 0.00011 21.4 0.2 4.3 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 EFC49604.1 - 2.3e-14 52.0 7.3 0.00049 19.8 0.2 4.8 4 1 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EFC49604.1 - 7.6e-14 51.9 8.3 1.1e-08 35.4 0.8 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 EFC49604.1 - 1.9e-09 36.5 8.0 0.0015 18.0 0.2 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EFC49604.1 - 3.1e-08 33.3 9.1 4.7e-05 23.1 0.4 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_4 PF12763.7 EFC49604.1 - 0.00025 21.0 3.8 0.42 10.6 0.1 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand VCBS PF13517.6 EFC49604.1 - 0.0091 16.6 0.1 4.3 8.0 0.0 2.8 2 0 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Dockerin_1 PF00404.18 EFC49604.1 - 0.04 14.1 0.0 0.79 10.0 0.0 2.5 2 0 0 2 2 2 0 Dockerin type I domain DUF2192 PF09958.9 EFC49604.1 - 0.15 11.6 1.8 0.47 9.9 0.5 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2192) SPARC_Ca_bdg PF10591.9 EFC49604.1 - 0.74 10.1 3.6 10 6.5 0.6 2.8 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region ubiquitin PF00240.23 EFC49605.1 - 1.7e-16 59.8 0.4 3.2e-16 58.8 0.4 1.5 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.11 EFC49605.1 - 2.9e-15 55.8 3.6 8.7e-15 54.2 2.5 2.4 3 0 0 3 3 3 1 XPC-binding domain UBA PF00627.31 EFC49605.1 - 2.7e-14 52.7 4.1 1.6e-09 37.4 0.3 2.9 3 0 0 3 3 3 2 UBA/TS-N domain Ubiquitin_5 PF18037.1 EFC49605.1 - 0.00011 22.5 0.3 0.00021 21.6 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 EFC49605.1 - 0.00086 19.8 0.3 0.0025 18.3 0.3 1.8 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 EFC49605.1 - 0.0014 18.4 0.2 0.0035 17.1 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like MCM_N PF14551.6 EFC49605.1 - 0.011 16.3 0.5 0.071 13.7 0.0 2.4 2 1 0 2 2 2 0 MCM N-terminal domain UBA_3 PF09288.10 EFC49605.1 - 0.016 15.0 0.0 2.3 8.1 0.0 2.6 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain SPATA3 PF15662.5 EFC49605.1 - 0.019 15.6 7.2 0.019 15.6 7.2 1.7 2 0 0 2 2 2 0 Spermatogenesis-associated protein 3 family SPESP1 PF15754.5 EFC49605.1 - 0.035 13.3 14.6 0.055 12.7 14.6 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 UBA_2 PF08587.11 EFC49605.1 - 0.093 12.9 0.2 0.42 10.8 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Mucin PF01456.17 EFC49605.1 - 0.55 10.2 45.2 0.63 10.0 35.9 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein CMV_1a PF12467.8 EFC49605.1 - 0.56 10.5 10.6 1.3 9.3 10.6 1.7 1 0 0 1 1 1 0 Cucumber mosaic virus 1a protein family MAP65_ASE1 PF03999.12 EFC49605.1 - 3.3 6.3 8.4 0.69 8.5 5.4 1.4 2 0 0 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) Shisa PF13908.6 EFC49605.1 - 4.6 7.4 11.8 0.5 10.6 6.9 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator FSA_C PF10479.9 EFC49605.1 - 5.9 4.9 11.5 9 4.3 11.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Dicty_REP PF05086.12 EFC49605.1 - 6.7 4.6 10.8 10 4.0 10.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ATF7IP_BD PF16788.5 EFC49605.1 - 8.4 6.4 19.0 1.2 9.2 14.5 1.8 2 0 0 2 2 2 0 ATF-interacting protein binding domain D123 PF07065.14 EFC49606.1 - 2.9e-88 296.0 4.1 3.7e-88 295.6 4.1 1.0 1 0 0 1 1 1 1 D123 CENP-B_dimeris PF09026.10 EFC49606.1 - 0.039 14.3 7.1 0.073 13.5 7.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain R2K_3 PF14243.6 EFC49606.1 - 0.067 13.2 0.1 0.099 12.6 0.1 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 cNMP_binding PF00027.29 EFC49607.1 - 2.5e-15 56.3 0.0 5e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Macro PF01661.21 EFC49608.1 - 8.8e-27 93.5 0.0 1.2e-26 93.1 0.0 1.2 1 0 0 1 1 1 1 Macro domain G-alpha PF00503.20 EFC49609.1 - 6.5e-100 334.7 2.5 7.8e-100 334.5 2.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 EFC49609.1 - 4.4e-10 39.3 5.7 4.6e-08 32.7 0.0 3.5 3 1 1 4 4 4 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC49609.1 - 0.0017 18.4 0.3 3 7.9 0.0 2.8 3 1 0 3 3 3 2 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC49609.1 - 0.01 15.2 1.6 1.9 7.8 0.0 2.7 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 EFC49609.1 - 0.014 15.9 0.0 0.028 15.0 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Roc PF08477.13 EFC49609.1 - 0.049 13.8 0.1 0.49 10.6 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 EFC49609.1 - 0.05 13.3 5.2 0.11 12.2 5.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain Cgr1 PF03879.14 EFC49609.1 - 0.058 13.8 1.4 1.5 9.2 0.1 2.4 2 0 0 2 2 2 0 Cgr1 family Chordopox_A33R PF05966.12 EFC49609.1 - 0.061 12.6 0.2 2.4 7.4 0.0 2.3 2 0 0 2 2 2 0 Chordopoxvirus A33R protein TniB PF05621.11 EFC49609.1 - 0.075 12.4 0.1 0.6 9.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_29 PF13555.6 EFC49609.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SepSecS PF05889.13 EFC49610.1 - 3.2e-116 388.2 0.1 3.8e-116 388.0 0.1 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 EFC49610.1 - 0.0097 15.2 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SinI PF08671.10 EFC49610.1 - 0.011 15.5 0.1 0.074 12.9 0.0 2.3 2 0 0 2 2 2 0 Anti-repressor SinI ATP13 PF12921.7 EFC49610.1 - 0.082 12.8 0.0 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ATPase expression DUF1116 PF06545.11 EFC49610.1 - 0.16 11.4 0.0 0.7 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1116) DGF-1_C PF11040.8 EFC49611.1 - 0.11 12.5 4.6 0.25 11.3 4.4 1.8 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus CH PF00307.31 EFC49612.1 - 3.6e-16 59.3 0.0 5.8e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 EFC49612.1 - 0.039 13.8 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain TPR_8 PF13181.6 EFC49613.1 - 0.15 12.3 0.7 5 7.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49613.1 - 0.93 10.0 4.1 30 5.3 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat EMC1_C PF07774.13 EFC49614.1 - 2.3e-62 210.4 0.9 2.3e-62 210.4 0.9 1.8 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 EFC49614.1 - 4.8e-10 39.4 4.6 9.5e-06 25.4 1.4 4.4 5 1 0 5 5 5 2 PQQ-like domain PQQ PF01011.21 EFC49614.1 - 4.1e-06 26.4 1.1 8.7 6.5 0.0 5.7 6 0 0 6 6 6 4 PQQ enzyme repeat ABC_tran PF00005.27 EFC49615.1 - 7.6e-29 101.0 0.0 2.9e-14 53.7 0.0 3.3 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 EFC49615.1 - 9.5e-13 48.4 10.4 1.6e-12 47.6 10.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_21 PF13304.6 EFC49615.1 - 9.8e-09 35.4 5.7 0.14 12.0 0.0 5.0 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC49615.1 - 9.9e-08 31.7 0.3 0.0075 15.7 0.0 4.3 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 EFC49615.1 - 6e-07 29.6 0.0 0.016 15.4 0.0 2.5 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 EFC49615.1 - 0.00013 21.7 0.0 0.59 9.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC49615.1 - 0.00081 19.2 0.0 0.41 10.3 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 EFC49615.1 - 0.0033 17.8 0.0 1 9.7 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 EFC49615.1 - 0.013 15.8 0.1 17 5.7 0.0 3.6 4 0 0 4 4 4 0 AAA domain AAA_25 PF13481.6 EFC49615.1 - 0.031 13.9 0.0 24 4.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 EFC49615.1 - 0.037 13.9 0.3 4.3 7.2 0.1 2.8 3 0 0 3 3 3 0 RsgA GTPase NACHT PF05729.12 EFC49615.1 - 0.072 13.0 0.0 3.7 7.4 0.0 2.8 2 0 0 2 2 2 0 NACHT domain TrwB_AAD_bind PF10412.9 EFC49615.1 - 0.11 11.4 0.4 5.3 5.9 0.0 2.9 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 EFC49615.1 - 0.21 11.3 0.3 8.1 6.1 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein RRM_1 PF00076.22 EFC49616.1 - 1.6e-43 146.3 6.8 4.3e-11 42.5 0.2 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ThaI PF15514.6 EFC49616.1 - 0.018 14.7 1.5 0.021 14.5 0.3 1.6 2 0 0 2 2 2 0 Restriction endonuclease ThaI SET_assoc PF11767.8 EFC49616.1 - 1.4 8.6 4.7 35 4.1 0.1 4.2 5 0 0 5 5 5 0 Histone lysine methyltransferase SET associated Epimerase PF01370.21 EFC49617.1 - 1.2e-17 64.1 0.0 1.8e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC49617.1 - 2.7e-14 52.8 0.0 6.5e-14 51.6 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 EFC49617.1 - 1e-08 34.7 0.0 2.9e-08 33.2 0.0 1.7 1 1 1 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 EFC49617.1 - 7.8e-07 28.8 0.1 3.3e-06 26.8 0.1 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 EFC49617.1 - 1.9e-06 27.9 0.0 0.00071 19.5 0.0 2.4 2 0 0 2 2 2 2 NAD(P)H-binding Polysacc_synt_2 PF02719.15 EFC49617.1 - 0.0092 15.2 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 EFC49617.1 - 0.036 14.0 0.0 0.082 12.8 0.0 1.7 1 1 0 1 1 1 0 KR domain HIT PF01230.23 EFC49617.1 - 0.071 13.9 0.0 0.15 12.9 0.0 1.5 1 0 0 1 1 1 0 HIT domain START PF01852.19 EFC49619.1 - 3.9e-05 23.1 0.0 6.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 START domain Auxin_resp PF06507.13 EFC49619.1 - 0.06 13.6 0.1 0.15 12.4 0.1 1.8 1 0 0 1 1 1 0 Auxin response factor SKA1 PF07160.12 EFC49619.1 - 0.12 12.3 2.5 0.22 11.3 2.5 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 WD40 PF00400.32 EFC49621.1 - 6.4e-14 52.1 7.3 0.0012 19.6 0.1 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49621.1 - 2.8e-10 40.3 0.0 0.0007 19.8 0.0 4.9 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 EFC49621.1 - 0.013 15.1 0.0 0.051 13.2 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain Myb_DNA-binding PF00249.31 EFC49622.1 - 2.8e-27 94.6 7.7 6.3e-15 55.1 0.3 3.7 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC49622.1 - 3.2e-21 75.3 1.7 7.4e-07 29.3 0.0 3.8 2 1 1 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 EFC49622.1 - 0.00092 19.2 0.1 2 8.5 0.0 2.8 1 1 0 2 2 2 2 SLIDE MCRS_N PF13325.6 EFC49622.1 - 0.0026 17.8 0.0 0.53 10.3 0.0 3.2 3 0 0 3 3 3 1 N-terminal region of micro-spherule protein Myb_DNA-bind_7 PF15963.5 EFC49622.1 - 0.0037 17.1 3.8 0.066 13.1 0.8 2.9 2 0 0 2 2 2 1 Myb DNA-binding like Ephrin_rec_like PF07699.13 EFC49624.1 - 8.5e-05 22.2 5.8 8.5e-05 22.2 5.8 8.3 6 3 3 9 9 9 5 Putative ephrin-receptor like C2 PF00168.30 EFC49625.1 - 6.5e-19 68.1 0.3 1.4e-18 67.0 0.3 1.6 1 0 0 1 1 1 1 C2 domain Ras PF00071.22 EFC49626.1 - 1.6e-54 183.8 0.2 1.9e-54 183.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49626.1 - 2e-20 73.2 0.0 3.2e-20 72.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49626.1 - 7.1e-11 41.9 0.1 8.6e-11 41.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC49626.1 - 9.4e-07 28.5 0.2 2.7e-06 27.1 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC49626.1 - 5.6e-06 26.4 0.0 0.0024 17.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 EFC49626.1 - 0.00013 21.1 0.6 0.0019 17.2 0.1 2.1 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EFC49626.1 - 0.00021 21.4 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC49626.1 - 0.0032 17.0 0.3 0.021 14.4 0.3 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B NB-ARC PF00931.22 EFC49626.1 - 0.012 14.8 1.0 0.26 10.5 0.1 2.4 1 1 2 3 3 3 0 NB-ARC domain AAA_22 PF13401.6 EFC49626.1 - 0.014 15.7 0.2 9.5 6.5 0.1 3.1 2 1 1 3 3 3 0 AAA domain TniB PF05621.11 EFC49626.1 - 0.058 12.8 0.1 6.2 6.2 0.0 2.7 2 1 1 3 3 3 0 Bacterial TniB protein Cofilin_ADF PF00241.20 EFC49627.1 - 2.5e-24 85.4 0.1 2.8e-24 85.2 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ANAPC16 PF17256.2 EFC49627.1 - 0.01 16.2 0.0 2.3 8.7 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, subunit 16 WW PF00397.26 EFC49628.1 - 3.9e-18 65.2 14.5 2.9e-09 36.9 3.2 2.9 2 0 0 2 2 2 2 WW domain Pes-10 PF07149.11 EFC49628.1 - 2.2 7.3 9.1 3.7 6.5 9.1 1.2 1 0 0 1 1 1 0 Pes-10 Myosin_head PF00063.21 EFC49629.1 - 4.1e-162 540.9 19.2 8.1e-94 315.2 1.9 3.3 3 0 0 3 3 3 3 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFC49629.1 - 8.9e-122 403.7 30.1 3.3e-42 144.3 0.8 5.1 5 0 0 5 5 5 4 Unconventional myosin tail, actin- and lipid-binding PH_3 PF14593.6 EFC49629.1 - 1.4e-06 28.4 4.7 0.00058 19.9 0.3 3.7 3 0 0 3 3 3 2 PH domain Pkinase PF00069.25 EFC49631.1 - 2.6e-47 161.4 0.2 4.1e-47 160.7 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49631.1 - 5.3e-29 101.3 0.0 8.8e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase NHL PF01436.21 EFC49631.1 - 1.3e-10 40.8 0.0 0.047 13.7 0.0 7.0 7 0 0 7 7 7 2 NHL repeat EGF_2 PF07974.13 EFC49631.1 - 1.8e-05 25.0 21.2 0.00071 19.9 7.1 2.4 2 0 0 2 2 2 2 EGF-like domain Haspin_kinase PF12330.8 EFC49631.1 - 3.5e-05 22.9 0.0 6e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain TMEM154 PF15102.6 EFC49631.1 - 0.00018 21.4 1.8 0.00043 20.2 1.8 1.6 1 0 0 1 1 1 1 TMEM154 protein family SGL PF08450.12 EFC49631.1 - 0.011 15.3 2.5 0.93 9.0 0.1 4.0 4 0 0 4 4 4 0 SMP-30/Gluconolactonase/LRE-like region DUF5385 PF17359.2 EFC49631.1 - 0.013 15.1 3.1 0.021 14.4 3.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) ASFV_J13L PF05568.11 EFC49631.1 - 0.019 14.7 1.9 0.047 13.4 1.9 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein Phage_holin_6_1 PF09682.10 EFC49631.1 - 0.096 13.1 2.9 0.34 11.4 2.9 2.0 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) EphA2_TM PF14575.6 EFC49631.1 - 0.1 13.5 0.1 0.22 12.4 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 EFC49631.1 - 0.17 12.1 1.4 0.93 9.8 0.5 2.5 2 0 0 2 2 2 0 Chordopoxvirus A13L protein EGF PF00008.27 EFC49631.1 - 0.2 12.0 10.2 0.93 9.9 2.5 2.5 2 0 0 2 2 2 0 EGF-like domain Laminin_EGF PF00053.24 EFC49631.1 - 0.92 9.7 17.7 5 7.4 6.7 2.4 1 1 1 2 2 2 0 Laminin EGF domain DUF3827 PF12877.7 EFC49631.1 - 1.6 7.0 5.1 2.4 6.4 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) hEGF PF12661.7 EFC49631.1 - 6 7.6 14.0 4 8.2 4.6 2.7 2 0 0 2 2 2 0 Human growth factor-like EGF Cation_efflux PF01545.21 EFC49632.1 - 3.4e-52 177.1 0.8 4.6e-52 176.7 0.8 1.2 1 0 0 1 1 1 1 Cation efflux family FAM176 PF14851.6 EFC49632.1 - 0.0075 15.9 1.3 0.056 13.1 0.0 2.2 2 0 0 2 2 2 1 FAM176 family Connexin PF00029.19 EFC49632.1 - 0.0089 15.8 0.5 0.19 11.4 0.1 2.4 2 0 0 2 2 2 1 Connexin V_ATPase_I PF01496.19 EFC49632.1 - 0.018 13.0 1.9 0.069 11.1 0.0 2.6 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family DUF2370 PF10176.9 EFC49632.1 - 0.17 11.5 1.8 1.4 8.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2370) Zip PF02535.22 EFC49632.1 - 1.8 7.7 29.1 4.7 6.3 14.7 2.8 2 2 0 2 2 2 0 ZIP Zinc transporter FAA_hydrolase PF01557.18 EFC49633.1 - 1.7e-38 132.5 0.0 3e-38 131.7 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Str_synth PF03088.16 EFC49633.1 - 2.9e-11 43.4 0.1 2.7e-10 40.2 0.0 2.5 1 1 1 2 2 2 2 Strictosidine synthase SGL PF08450.12 EFC49633.1 - 0.00056 19.6 0.0 0.0011 18.6 0.0 1.5 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region OLF PF02191.16 EFC49633.1 - 0.0053 16.3 0.1 0.0099 15.4 0.1 1.4 1 0 0 1 1 1 1 Olfactomedin-like domain Peptidase_S10 PF00450.22 EFC49634.1 - 2.8e-88 297.1 8.4 3.3e-88 296.9 8.4 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF4713 PF15831.5 EFC49634.1 - 3.6 8.1 7.5 6.7 7.2 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Actin PF00022.19 EFC49635.1 - 5.3e-149 496.3 0.0 2.1e-148 494.3 0.0 1.7 1 1 0 1 1 1 1 Actin ASC PF00858.24 EFC49636.1 - 7.2e-15 54.9 12.3 1.7e-06 27.3 1.2 3.1 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel AAA_13 PF13166.6 EFC49637.1 - 0.01 14.5 3.9 0.015 13.9 3.8 1.2 1 1 0 1 1 1 0 AAA domain Occludin_ELL PF07303.13 EFC49637.1 - 0.01 16.5 1.1 0.01 16.5 1.1 2.7 2 1 0 2 2 2 0 Occludin homology domain DUF948 PF06103.11 EFC49637.1 - 0.026 14.8 1.9 4.9 7.5 1.2 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec8_exocyst PF04048.14 EFC49637.1 - 0.031 14.2 0.1 0.031 14.2 0.1 2.5 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain DUF2959 PF11172.8 EFC49637.1 - 0.058 13.5 0.2 0.058 13.5 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2959) IFT57 PF10498.9 EFC49637.1 - 0.095 11.7 0.1 0.095 11.7 0.1 2.1 2 0 0 2 2 1 0 Intra-flagellar transport protein 57 NPV_P10 PF05531.12 EFC49637.1 - 0.22 12.0 7.6 0.53 10.8 0.0 2.8 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 EFC49637.1 - 0.48 10.8 0.0 0.48 10.8 0.0 3.0 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 EFC49637.1 - 0.66 10.3 6.8 1.9 8.8 0.1 2.8 2 1 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Presenilin PF01080.17 EFC49637.1 - 0.95 8.2 2.9 1 8.0 2.9 1.2 1 0 0 1 1 1 0 Presenilin Laminin_II PF06009.12 EFC49637.1 - 1.3 9.0 8.4 0.62 10.1 3.2 2.5 2 1 0 2 2 1 0 Laminin Domain II DUF573 PF04504.14 EFC49637.1 - 1.9 9.2 10.0 0.57 10.9 2.3 2.7 1 1 1 2 2 2 0 Protein of unknown function, DUF573 DUF1664 PF07889.12 EFC49637.1 - 3 7.9 7.4 0.19 11.7 0.8 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) EzrA PF06160.12 EFC49637.1 - 4 5.5 11.3 0.028 12.6 0.9 2.2 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Atg14 PF10186.9 EFC49637.1 - 7.4 5.5 7.5 42 3.1 7.4 2.2 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EamA PF00892.20 EFC49638.1 - 5.4e-24 84.9 40.5 2e-17 63.7 17.2 3.2 3 0 0 3 3 3 3 EamA-like transporter family DUF4131 PF13567.6 EFC49638.1 - 0.35 10.5 5.9 1.2 8.8 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) RseC_MucC PF04246.12 EFC49638.1 - 1.9 8.4 6.8 6.4 6.7 0.1 2.9 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DUF1011 PF06237.12 EFC49638.1 - 3.4 8.1 12.4 0.85 10.0 0.2 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1011) Exo_endo_phos PF03372.23 EFC49639.1 - 0.00028 20.5 0.0 0.00067 19.2 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4241 PF14025.6 EFC49640.1 - 1.5e-33 116.7 0.2 1.5e-33 116.7 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4241) DUF1811 PF08838.10 EFC49640.1 - 0.25 11.6 1.1 1.3 9.3 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) EF-hand_1 PF00036.32 EFC49641.1 - 5e-14 50.7 11.2 0.00017 20.9 0.3 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 EFC49641.1 - 3.6e-13 49.8 8.1 2.4e-08 34.3 2.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC49641.1 - 3.9e-12 45.1 5.9 0.0011 18.7 0.2 4.2 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 EFC49641.1 - 7.5e-10 38.5 7.4 0.01 15.7 0.1 3.3 3 0 0 3 3 3 3 EF-hand domain pair p25-alpha PF05517.12 EFC49641.1 - 0.0097 16.1 0.2 2.5 8.2 0.0 2.4 1 1 1 2 2 2 1 p25-alpha EF-hand_5 PF13202.6 EFC49641.1 - 0.019 14.4 11.1 0.45 10.1 0.4 4.1 4 0 0 4 4 4 0 EF hand EF-hand_10 PF14788.6 EFC49641.1 - 0.028 14.3 0.2 0.076 12.9 0.2 1.8 1 0 0 1 1 1 0 EF hand SPARC_Ca_bdg PF10591.9 EFC49641.1 - 0.049 14.0 1.8 0.073 13.4 0.9 1.8 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 EFC49641.1 - 0.17 11.9 4.6 15 5.6 1.2 2.8 1 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand BTB PF00651.31 EFC49642.1 - 2.3e-10 40.7 1.4 5.2e-09 36.3 0.4 2.7 2 0 0 2 2 2 1 BTB/POZ domain Ank_2 PF12796.7 EFC49642.1 - 1.2e-05 25.8 0.0 0.00026 21.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) DUF3342 PF11822.8 EFC49642.1 - 0.00014 22.0 0.7 0.00041 20.5 0.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) Ank_3 PF13606.6 EFC49642.1 - 0.021 15.4 0.1 0.093 13.3 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 EFC49642.1 - 0.042 14.2 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) EFG_IV PF03764.18 EFC49643.1 - 2.8e-23 82.0 0.0 1.4e-22 79.7 0.0 2.3 2 1 1 3 3 3 1 Elongation factor G, domain IV GTP_EFTU PF00009.27 EFC49643.1 - 4e-14 52.6 0.0 6.3e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 EFC49643.1 - 3e-09 36.9 0.1 5.4e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 EFC49643.1 - 4.6e-08 33.3 0.3 1e-07 32.2 0.3 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_C PF00679.24 EFC49643.1 - 2.9e-05 24.0 0.0 6.8e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus Chlorosome_CsmC PF11098.8 EFC49643.1 - 0.045 13.7 0.3 0.64 10.0 0.3 2.3 2 0 0 2 2 2 0 Chlorosome envelope protein C SSP160 PF06933.11 EFC49644.1 - 4.4 5.4 6.5 1.6 6.8 4.0 1.4 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 BKACE PF05853.12 EFC49646.1 - 1.4e-81 273.8 0.0 1.7e-81 273.6 0.0 1.0 1 0 0 1 1 1 1 beta-keto acid cleavage enzyme DUF4116 PF13475.6 EFC49648.1 - 2.1e-66 219.4 2.7 6.1e-14 51.5 0.0 10.1 10 1 1 11 11 11 9 Domain of unknown function (DUF4116) GABP-alpha PF11620.8 EFC49648.1 - 0.33 11.2 2.5 9.2 6.5 0.2 3.1 2 1 1 3 3 3 0 GA-binding protein alpha chain RasGEF PF00617.19 EFC49649.1 - 1.5e-33 116.5 4.8 1.5e-33 116.5 4.8 2.7 2 1 1 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 EFC49649.1 - 1.5e-14 54.1 2.5 1.5e-14 54.1 2.5 2.5 3 0 0 3 3 3 1 RasGEF N-terminal motif TPT PF03151.16 EFC49650.1 - 7.4e-13 48.5 27.1 1.3e-11 44.4 27.1 2.1 1 1 0 1 1 1 1 Triose-phosphate Transporter family D123 PF07065.14 EFC49651.1 - 1.1e-24 87.2 0.4 1.1e-24 87.2 0.4 2.2 2 1 0 2 2 2 1 D123 R2K_2 PF18299.1 EFC49651.1 - 0.00098 19.0 0.0 0.0021 17.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 Com_YlbF PF06133.11 EFC49651.1 - 1.7 9.3 13.6 2.8 8.6 0.3 4.2 4 0 0 4 4 4 0 Control of competence regulator ComK, YlbF/YmcA VWA PF00092.28 EFC49653.1 - 6.4e-08 33.0 0.7 6.4e-08 33.0 0.7 2.4 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC49653.1 - 5.4e-07 30.2 0.6 5.5e-06 27.0 0.1 2.8 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC49653.1 - 0.0015 17.9 0.1 0.0061 16.0 0.0 2.0 3 0 0 3 3 3 1 VWA domain containing CoxE-like protein DUF2201 PF09967.9 EFC49653.1 - 0.016 15.3 0.0 0.042 14.0 0.0 1.7 1 0 0 1 1 1 0 VWA-like domain (DUF2201) SSXT PF05030.12 EFC49653.1 - 0.15 11.7 2.4 0.11 12.2 0.2 1.9 2 0 0 2 2 2 0 SSXT protein (N-terminal region) Actin PF00022.19 EFC49654.1 - 4e-28 98.1 0.1 1.7e-14 53.2 0.0 2.1 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 EFC49654.1 - 0.046 12.5 0.1 0.062 12.1 0.1 1.2 1 0 0 1 1 1 0 MreB/Mbl protein adh_short PF00106.25 EFC49655.1 - 3.6e-28 98.4 0.1 7.4e-26 90.8 0.2 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC49655.1 - 2.4e-20 73.1 0.0 4.5e-18 65.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC49655.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 KR domain SpoIIM PF01944.17 EFC49655.1 - 0.013 15.5 0.4 0.096 12.7 0.0 2.3 1 1 0 2 2 2 0 Stage II sporulation protein M YppG PF14179.6 EFC49656.1 - 0.00046 20.8 3.9 0.0053 17.4 1.9 2.2 2 0 0 2 2 2 2 YppG-like protein Ion_trans_2 PF07885.16 EFC49658.1 - 9.4e-33 112.0 27.8 9.7e-18 63.9 6.8 2.7 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 EFC49658.1 - 5e-14 52.1 12.0 4.9e-07 29.2 1.5 2.2 1 1 1 2 2 2 2 Ion transport protein DUF2207 PF09972.9 EFC49658.1 - 0.087 11.6 11.5 4.2 6.0 11.1 2.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) LRR_6 PF13516.6 EFC49659.1 - 1.3e-40 134.0 14.4 1.7e-05 24.5 0.0 12.2 12 0 0 12 12 12 9 Leucine Rich repeat LRR_8 PF13855.6 EFC49659.1 - 1e-27 95.7 45.3 3.4e-08 33.1 2.3 6.0 2 1 7 9 9 9 8 Leucine rich repeat LRR_4 PF12799.7 EFC49659.1 - 5.1e-21 74.4 22.9 1.8e-05 25.0 0.6 7.2 2 1 6 9 9 9 7 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC49659.1 - 3.4e-11 43.0 6.4 3.4e-06 26.7 0.6 4.6 1 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 EFC49659.1 - 6.3e-11 41.2 7.7 1.4 9.8 0.0 9.2 11 0 0 11 11 10 1 Leucine Rich Repeat DUF4347 PF14252.6 EFC49659.1 - 8.3e-06 25.8 0.2 3.4 7.5 0.0 5.8 2 2 2 6 6 6 1 Domain of unknown function (DUF4347) F-box-like PF12937.7 EFC49659.1 - 0.00029 20.7 0.0 0.00058 19.7 0.0 1.4 1 0 0 1 1 1 1 F-box-like Apo-VLDL-II PF05418.11 EFC49659.1 - 0.0074 16.8 0.1 1.7 9.3 0.1 3.7 4 1 3 7 7 7 1 Apovitellenin I (Apo-VLDL-II) LRR_2 PF07723.13 EFC49659.1 - 0.0093 16.6 0.3 35 5.3 0.0 5.1 6 0 0 6 6 6 0 Leucine Rich Repeat F-box PF00646.33 EFC49659.1 - 0.02 14.8 0.8 0.046 13.6 0.1 1.9 2 0 0 2 2 2 0 F-box domain ApoB100_C PF12491.8 EFC49659.1 - 2.6 8.1 10.1 13 5.8 0.1 5.8 4 2 3 7 7 7 0 Apolipoprotein B100 C terminal Profilin PF00235.19 EFC49660.1 - 1.2e-10 41.7 0.1 1.5e-10 41.5 0.1 1.0 1 0 0 1 1 1 1 Profilin tRNA-synt_1b PF00579.25 EFC49661.1 - 2.3e-23 82.9 0.1 6.8e-23 81.4 0.1 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Cation_ATPase PF13246.6 EFC49661.1 - 0.071 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) HsdM_N PF12161.8 EFC49661.1 - 0.13 12.9 2.5 13 6.4 0.5 3.1 2 1 0 2 2 2 0 HsdM N-terminal domain DnaJ_C PF01556.18 EFC49663.1 - 5.6e-39 133.6 1.1 8.1e-39 133.1 1.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFC49663.1 - 7.8e-21 74.0 3.1 1.3e-20 73.2 3.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFC49663.1 - 2.3e-12 47.1 12.7 4.2e-12 46.2 12.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFC49663.1 - 0.00047 20.1 4.5 0.42 10.6 0.5 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Aminopep PF10023.9 EFC49663.1 - 0.15 11.4 0.2 0.22 10.8 0.2 1.2 1 0 0 1 1 1 0 Putative aminopeptidase RRM_1 PF00076.22 EFC49664.1 - 4.8e-09 35.9 0.1 0.00053 19.8 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SYS1 PF09801.9 EFC49665.1 - 1.2e-36 126.0 13.7 1.4e-36 125.8 13.7 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network DUF4408 PF14364.6 EFC49665.1 - 0.0027 17.4 0.1 0.0086 15.8 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4408) OATP PF03137.20 EFC49665.1 - 0.064 11.5 7.7 0.049 11.9 4.8 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family S1FA PF04689.13 EFC49665.1 - 0.11 12.6 2.3 0.95 9.6 0.0 2.8 3 0 0 3 3 3 0 DNA binding protein S1FA Peptidase_C13 PF01650.18 EFC49666.1 - 8.7e-92 307.2 0.9 9.7e-92 307.1 0.9 1.0 1 0 0 1 1 1 1 Peptidase C13 family WD40 PF00400.32 EFC49667.1 - 4.1e-49 163.5 15.9 3.5e-11 43.5 0.3 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49667.1 - 1.6e-23 82.8 0.1 0.00014 22.0 0.0 5.2 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC49667.1 - 2.1e-13 49.8 1.5 0.012 14.3 0.0 5.0 2 1 2 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 EFC49667.1 - 1.9e-11 43.5 0.3 0.05 12.6 0.1 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC49667.1 - 4.1e-05 23.1 0.1 0.0072 15.7 0.0 2.8 3 0 0 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 EFC49667.1 - 7e-05 21.7 0.1 0.25 10.0 0.0 3.2 3 1 0 3 3 3 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 EFC49667.1 - 0.0011 17.5 0.0 0.014 14.0 0.0 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain DUF1513 PF07433.11 EFC49667.1 - 0.0014 17.8 0.0 13 4.8 0.0 3.7 2 2 1 3 3 3 1 Protein of unknown function (DUF1513) Hira PF07569.11 EFC49667.1 - 0.013 15.3 3.1 2.5 7.8 0.1 3.6 3 1 1 4 4 4 0 TUP1-like enhancer of split PALB2_WD40 PF16756.5 EFC49667.1 - 0.019 13.9 1.4 2.6 6.9 0.0 3.8 2 1 2 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 EFC49667.1 - 0.021 13.2 0.0 7.1 4.8 0.0 2.9 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 EFC49667.1 - 0.025 13.7 0.0 0.19 10.7 0.0 2.3 3 0 0 3 3 3 0 VID27 C-terminal WD40-like domain Antistasin PF02822.14 EFC49668.1 - 7.7e-22 77.6 44.5 6.4e-08 33.1 9.2 3.2 3 0 0 3 3 3 3 Antistasin family Rieske PF00355.26 EFC49671.1 - 3.3e-17 62.2 0.9 8.1e-17 61.0 0.2 2.0 1 1 1 2 2 2 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EFC49671.1 - 0.00063 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain BTB_2 PF02214.22 EFC49672.1 - 0.22 11.9 1.9 0.62 10.5 0.1 2.1 2 0 0 2 2 2 0 BTB/POZ domain HGTP_anticodon PF03129.20 EFC49673.1 - 4.6e-10 39.5 0.0 1.3e-09 38.1 0.0 1.8 1 0 0 1 1 1 1 Anticodon binding domain ProRS-C_1 PF09180.11 EFC49673.1 - 0.011 15.9 0.0 0.031 14.5 0.0 1.8 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal Cyclin_N PF00134.23 EFC49674.1 - 5.6e-14 52.0 0.1 1.8e-12 47.1 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain PhoLip_ATPase_C PF16212.5 EFC49675.1 - 1.1e-39 136.7 12.3 1.1e-39 136.7 12.3 2.1 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 EFC49675.1 - 2.5e-14 52.7 3.5 7.3e-14 51.2 3.5 1.8 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 EFC49675.1 - 1.1e-13 51.1 0.2 1.1e-13 51.1 0.2 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 EFC49675.1 - 2.7e-09 37.6 0.1 0.00017 22.0 0.0 3.4 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC49675.1 - 2e-08 34.2 0.0 1.5e-07 31.4 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC49675.1 - 0.012 15.4 0.6 0.42 10.3 0.0 3.2 2 1 2 4 4 4 0 haloacid dehalogenase-like hydrolase Ank_2 PF12796.7 EFC49676.1 - 2.2e-13 50.6 0.0 1.9e-12 47.6 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC49676.1 - 2.5e-13 50.2 0.1 1.4e-11 44.7 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC49676.1 - 3.8e-10 39.8 0.1 2.1e-05 24.7 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC49676.1 - 2.2e-09 36.7 0.2 0.0018 18.6 0.1 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 EFC49676.1 - 2.4e-08 34.0 0.1 0.00011 22.5 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Aquarius_N PF16399.5 EFC49677.1 - 4e-158 527.9 12.8 6.3e-158 527.3 12.8 1.2 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 EFC49677.1 - 9.8e-23 81.3 0.0 2.8e-22 79.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_12 PF13087.6 EFC49677.1 - 1.2e-21 77.3 0.8 5e-20 72.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 EFC49677.1 - 4.9e-07 29.7 0.0 0.0018 18.0 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 EFC49677.1 - 2e-05 25.0 0.0 4.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFC49677.1 - 0.013 15.5 0.9 0.048 13.7 0.1 2.4 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 EFC49677.1 - 0.015 15.1 2.2 2.8 7.6 0.0 3.8 5 1 1 6 6 6 0 Viral (Superfamily 1) RNA helicase CTV_P23 PF04808.12 EFC49677.1 - 0.078 12.5 0.0 6 6.4 0.0 2.5 2 0 0 2 2 2 0 Citrus tristeza virus (CTV) P23 protein Peptidase_M15_2 PF05951.13 EFC49677.1 - 0.099 12.3 0.0 0.29 10.8 0.0 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF882) FAM76 PF16046.5 EFC49678.1 - 0.064 12.6 7.9 0.093 12.1 7.9 1.2 1 0 0 1 1 1 0 FAM76 protein Myb_DNA-bind_3 PF12776.7 EFC49678.1 - 0.08 13.9 3.6 0.065 14.2 1.6 1.9 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain bZIP_1 PF00170.21 EFC49678.1 - 0.14 12.3 3.7 0.32 11.1 3.7 1.6 1 0 0 1 1 1 0 bZIP transcription factor XhlA PF10779.9 EFC49678.1 - 0.64 10.3 2.3 1.9 8.7 2.3 1.7 1 0 0 1 1 1 0 Haemolysin XhlA DivIC PF04977.15 EFC49678.1 - 3 7.7 7.0 3.9 7.3 5.1 1.9 1 1 0 1 1 1 0 Septum formation initiator COMM_domain PF07258.14 EFC49679.1 - 1.1e-17 63.9 1.5 1.1e-17 63.9 1.5 1.6 2 0 0 2 2 2 1 COMM domain Ribosomal_S6 PF01250.17 EFC49680.1 - 1.9e-22 79.4 0.0 3.5e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S6 CheW PF01584.19 EFC49681.1 - 0.14 11.8 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 CheW-like domain Ras PF00071.22 EFC49682.1 - 6.5e-06 25.8 0.0 2.2e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 Ras family AAA_22 PF13401.6 EFC49682.1 - 0.011 16.0 0.0 0.047 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain F-box PF00646.33 EFC49682.1 - 0.022 14.7 0.5 0.059 13.3 0.5 1.9 1 0 0 1 1 1 0 F-box domain AAA_24 PF13479.6 EFC49682.1 - 0.032 14.0 0.0 0.074 12.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain Ubie_methyltran PF01209.18 EFC49682.1 - 0.066 12.5 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RsgA_GTPase PF03193.16 EFC49682.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 EFC49682.1 - 0.082 13.3 0.0 0.21 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 EFC49682.1 - 0.092 12.5 0.1 0.81 9.4 0.1 2.4 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cas_Csy3 PF09615.10 EFC49682.1 - 0.11 11.8 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy3) AAA_28 PF13521.6 EFC49682.1 - 0.12 12.6 0.0 0.34 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA-ATPase_like PF09820.9 EFC49683.1 - 5.8e-58 196.5 0.8 5.8e-58 196.5 0.8 2.8 2 1 1 3 3 3 1 Predicted AAA-ATPase PDDEXK_9 PF08011.11 EFC49683.1 - 0.0015 18.4 3.0 1.5 8.8 3.0 3.0 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AAA_22 PF13401.6 EFC49683.1 - 0.1 12.9 0.1 1.1 9.5 0.0 2.6 2 1 1 3 3 3 0 AAA domain NERD PF08378.11 EFC49683.1 - 0.65 10.5 3.8 0.43 11.1 0.3 2.6 3 0 0 3 3 3 0 Nuclease-related domain CTU2 PF10288.9 EFC49684.1 - 2.1e-11 44.0 3.9 2.1e-11 44.0 3.9 2.9 2 1 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 Cullin_Nedd8 PF10557.9 EFC49684.1 - 0.0034 17.4 1.5 0.035 14.1 0.0 2.9 3 0 0 3 3 3 1 Cullin protein neddylation domain ATP_bind_3 PF01171.20 EFC49684.1 - 0.056 13.2 0.0 0.23 11.2 0.0 2.0 1 1 0 1 1 1 0 PP-loop family Tom5 PF10642.9 EFC49684.1 - 2.3 8.3 5.6 1.4 9.0 3.0 2.0 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase IF4E PF01652.18 EFC49685.1 - 1.5e-41 141.8 0.5 2.1e-41 141.3 0.5 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2684 PF10885.8 EFC49685.1 - 0.15 12.2 0.2 0.47 10.6 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2684) HK PF02110.15 EFC49686.1 - 3.2e-72 242.9 0.3 3.2e-72 242.9 0.3 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 EFC49686.1 - 6.4e-56 188.5 0.2 6.4e-56 188.5 0.2 1.6 2 0 0 2 2 2 1 Thiamine monophosphate synthase Carb_kinase PF01256.17 EFC49686.1 - 0.0023 17.5 0.5 0.01 15.4 0.4 1.9 1 1 1 2 2 2 1 Carbohydrate kinase ThiG PF05690.14 EFC49686.1 - 0.016 14.5 0.1 0.049 12.9 0.0 1.9 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG adh_short PF00106.25 EFC49686.1 - 0.017 14.6 1.1 0.57 9.6 1.3 2.5 2 0 0 2 2 2 0 short chain dehydrogenase Drf_FH3 PF06367.16 EFC49686.1 - 0.018 14.7 0.0 0.032 13.8 0.0 1.3 1 0 0 1 1 1 0 Diaphanous FH3 Domain Phos_pyr_kin PF08543.12 EFC49686.1 - 0.028 13.8 0.1 0.055 12.8 0.1 1.5 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase MutS_V PF00488.21 EFC49687.1 - 2e-70 236.7 1.1 4.1e-70 235.7 1.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFC49687.1 - 5.3e-35 121.4 1.3 5.3e-35 121.4 1.3 3.1 2 1 0 3 3 3 1 MutS domain III MutS_II PF05188.17 EFC49687.1 - 1.8e-10 41.3 0.8 1.8e-10 41.3 0.8 2.8 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 EFC49687.1 - 5.6e-05 23.4 1.2 5.6e-05 23.4 1.2 2.8 3 0 0 3 3 3 1 MutS family domain IV Rad17 PF03215.15 EFC49687.1 - 0.0012 18.8 0.1 0.0067 16.4 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_27 PF13514.6 EFC49687.1 - 0.0018 17.9 0.0 0.0075 15.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain CK2S PF15011.6 EFC49687.1 - 0.025 14.5 7.2 0.05 13.5 0.6 3.3 3 0 0 3 3 3 0 Casein Kinase 2 substrate AAA_29 PF13555.6 EFC49687.1 - 0.15 11.8 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 EFC49687.1 - 0.63 10.5 0.0 0.63 10.5 0.0 4.7 3 1 0 3 3 3 0 AAA domain APG17 PF04108.12 EFC49688.1 - 0.0045 16.2 10.4 0.012 14.8 7.9 2.8 1 1 1 2 2 2 1 Autophagy protein Apg17 SAM_KSR1 PF13543.6 EFC49688.1 - 0.0085 16.2 17.3 0.33 11.1 0.1 5.5 3 2 2 6 6 6 2 SAM like domain present in kinase suppressor RAS 1 Adenine_glyco PF03352.13 EFC49688.1 - 0.054 13.3 4.9 0.08 12.7 0.3 3.1 1 1 1 3 3 3 0 Methyladenine glycosylase DUF4313 PF14190.6 EFC49688.1 - 0.099 12.6 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4313) HHH_8 PF14716.6 EFC49688.1 - 0.19 12.1 4.0 1.2 9.6 0.1 3.9 4 0 0 4 4 4 0 Helix-hairpin-helix domain PDZ_2 PF13180.6 EFC49688.1 - 0.2 12.0 4.0 1.4 9.3 0.1 3.8 4 0 0 4 4 4 0 PDZ domain Sirohm_synth_C PF14823.6 EFC49688.1 - 0.22 11.2 9.3 39 4.0 0.1 5.6 6 0 0 6 6 6 0 Sirohaem biosynthesis protein C-terminal DegS PF05384.11 EFC49688.1 - 0.25 10.8 12.4 0.99 8.9 4.1 4.6 4 2 1 5 5 5 0 Sensor protein DegS SAM_1 PF00536.30 EFC49688.1 - 1.1 9.7 5.6 9.3 6.8 0.1 4.1 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) DUF4559 PF15112.6 EFC49688.1 - 2 8.0 19.6 1.1 8.9 0.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4559) Imm3 PF14425.6 EFC49688.1 - 3.3 7.8 12.4 6.9 6.8 0.3 4.7 3 2 1 5 5 5 0 Immunity protein Imm3 TPR_MLP1_2 PF07926.12 EFC49688.1 - 5 7.2 10.4 0.45 10.6 4.1 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein CREPT PF16566.5 EFC49688.1 - 6.7 6.9 8.7 17 5.6 0.4 3.5 2 1 2 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour Fez1 PF06818.15 EFC49688.1 - 8.1 6.8 17.7 0.51 10.7 9.5 2.5 2 1 0 2 2 2 0 Fez1 DUF948 PF06103.11 EFC49688.1 - 8.2 6.8 18.8 14 6.0 0.1 6.7 4 1 3 8 8 8 0 Bacterial protein of unknown function (DUF948) p450 PF00067.22 EFC49689.1 - 4.6e-79 266.3 0.1 5.8e-79 266.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 YL1 PF05764.13 EFC49690.1 - 0.03 14.4 38.7 0.046 13.8 38.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUSP PF06337.12 EFC49690.1 - 0.65 10.7 5.1 1.6 9.4 4.9 2.0 1 1 0 1 1 1 0 DUSP domain Hamartin PF04388.12 EFC49690.1 - 3.9 6.0 23.0 5 5.7 23.0 1.1 1 0 0 1 1 1 0 Hamartin protein YbaB_DNA_bd PF02575.16 EFC49691.1 - 2.9e-08 33.8 0.1 5.9e-08 32.8 0.1 1.5 1 0 0 1 1 1 1 YbaB/EbfC DNA-binding family DUF3907 PF13047.6 EFC49691.1 - 0.091 12.7 3.8 4.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3907) RasGAP_C PF03836.15 EFC49691.1 - 0.27 11.4 7.9 0.081 13.1 4.0 1.9 2 0 0 2 2 2 0 RasGAP C-terminus RR_TM4-6 PF06459.12 EFC49692.1 - 1.2 8.9 7.9 1.8 8.4 7.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5427 PF10310.9 EFC49692.1 - 2 7.3 10.4 2.8 6.8 10.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CAML PF14963.6 EFC49692.1 - 2.6 8.1 5.2 3.8 7.6 5.2 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Ndc1_Nup PF09531.10 EFC49692.1 - 4.8 5.8 7.7 5.2 5.6 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Beta-lactamase PF00144.24 EFC49694.1 - 7.8e-51 173.3 0.0 4.7e-33 114.8 0.0 2.2 2 0 0 2 2 2 2 Beta-lactamase Peptidase_S11 PF00768.20 EFC49694.1 - 0.017 14.6 0.1 7 6.0 0.1 2.7 2 0 0 2 2 2 0 D-alanyl-D-alanine carboxypeptidase GTP_EFTU PF00009.27 EFC49695.1 - 0.075 12.6 0.1 0.094 12.2 0.1 1.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain NHL PF01436.21 EFC49696.1 - 1.8e-70 229.6 19.1 1.7e-07 30.9 0.1 12.4 12 0 0 12 12 12 11 NHL repeat SGL PF08450.12 EFC49696.1 - 8.7e-08 32.0 4.8 0.004 16.8 0.3 5.0 2 1 2 4 4 4 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 EFC49696.1 - 7.5e-06 26.1 8.0 0.5 10.6 0.0 5.9 5 1 1 6 6 6 2 Arylesterase SBBP PF06739.11 EFC49696.1 - 0.0051 16.8 34.2 0.36 10.9 0.0 7.4 7 0 0 7 7 7 3 Beta-propeller repeat Phytase-like PF13449.6 EFC49696.1 - 0.0068 16.4 0.3 73 3.2 0.0 5.7 6 2 0 6 6 6 0 Esterase-like activity of phytase Linker_histone PF00538.19 EFC49696.1 - 0.01 16.2 0.0 54 4.3 0.0 5.2 4 0 0 4 4 4 0 linker histone H1 and H5 family DUF1921 PF09081.10 EFC49696.1 - 4.2 7.7 15.9 5.7 7.3 0.0 6.0 7 0 0 7 7 7 0 Domain of unknown function (DUF1921) Asn_synthase PF00733.21 EFC49697.1 - 4.3e-86 289.8 2.5 1.6e-50 172.7 1.4 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 EFC49697.1 - 2e-38 131.1 0.0 4e-38 130.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 EFC49697.1 - 1.7e-28 99.4 0.0 3.6e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 EFC49697.1 - 2e-08 33.7 0.1 3.5e-08 32.9 0.1 1.3 1 0 0 1 1 1 1 NAD synthase DUF3700 PF12481.8 EFC49697.1 - 2.7e-05 23.7 0.1 5e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 Aluminium induced protein QueC PF06508.13 EFC49697.1 - 0.0028 17.2 0.0 0.0052 16.3 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC RGS PF00615.19 EFC49698.1 - 6.8e-08 32.8 4.9 2.3e-06 27.9 4.9 2.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Amidase PF01425.21 EFC49699.1 - 4.4e-124 414.9 0.0 5.1e-124 414.7 0.0 1.0 1 0 0 1 1 1 1 Amidase PPR_3 PF13812.6 EFC49700.1 - 0.01 15.9 0.4 0.049 13.7 0.2 2.3 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 EFC49700.1 - 0.018 15.2 0.0 0.018 15.2 0.0 3.5 4 1 0 4 4 4 0 PPR repeat family DUF5560 PF17715.1 EFC49701.1 - 0.065 12.7 2.9 0.12 11.8 2.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5560) FUSC PF04632.12 EFC49701.1 - 0.094 11.2 1.0 0.18 10.3 0.4 1.7 2 0 0 2 2 2 0 Fusaric acid resistance protein family XhlA PF10779.9 EFC49701.1 - 0.19 11.9 9.5 3.1 8.1 1.6 3.2 1 1 1 3 3 3 0 Haemolysin XhlA FlaC_arch PF05377.11 EFC49701.1 - 0.96 9.9 11.9 0.089 13.2 3.5 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Histone PF00125.24 EFC49702.1 - 2.3e-50 170.3 4.7 2.6e-50 170.2 4.7 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 EFC49702.1 - 1.7e-05 25.4 0.8 1.9e-05 25.3 0.8 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 EFC49702.1 - 7.9e-05 22.7 0.3 7.9e-05 22.7 0.3 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFC49702.1 - 0.0003 21.1 0.1 0.00046 20.5 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFC49702.1 - 0.012 15.9 0.6 0.023 14.9 0.1 1.7 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 EFC49702.1 - 0.11 12.5 0.9 0.15 12.1 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit UQ_con PF00179.26 EFC49703.1 - 8.4e-16 57.9 0.0 8.6e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Laminin_G_3 PF13385.6 EFC49704.1 - 1.5e-16 60.9 0.2 2.8e-16 60.0 0.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 EFC49704.1 - 0.00036 20.3 0.1 0.00087 19.0 0.1 1.6 1 1 0 1 1 1 1 Pentaxin family Pro_sub2 PF18513.1 EFC49704.1 - 0.077 13.2 0.0 0.27 11.4 0.0 2.0 1 0 0 1 1 1 0 Prodomain subtilisin 2 Lactamase_B_2 PF12706.7 EFC49705.1 - 1.1e-12 47.9 0.0 1.4e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC49705.1 - 1.6e-06 28.1 0.0 1.5e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFC49705.1 - 0.00096 19.2 0.1 0.0018 18.3 0.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily FRD2 PF03197.13 EFC49705.1 - 0.0017 18.6 0.3 0.0043 17.3 0.1 1.8 2 0 0 2 2 2 1 Bacteriophage FRD2 protein Tox-SGS PF15651.6 EFC49706.1 - 0.0087 16.3 1.0 8.1 6.8 0.1 3.1 3 0 0 3 3 3 2 Salivary glad secreted protein domain toxin PuR_N PF09182.10 EFC49706.1 - 0.079 12.9 0.0 0.26 11.3 0.0 1.9 1 0 0 1 1 1 0 Bacterial purine repressor, N-terminal ABC_tran PF00005.27 EFC49707.1 - 1.3e-22 80.8 0.0 1.9e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 EFC49707.1 - 0.0013 18.7 0.1 0.0023 17.8 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 EFC49707.1 - 0.012 15.4 0.5 0.028 14.2 0.5 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 EFC49707.1 - 0.014 14.9 0.0 0.052 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 EFC49707.1 - 0.028 14.7 0.0 0.084 13.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 EFC49707.1 - 0.029 14.4 0.1 0.068 13.3 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 EFC49707.1 - 0.029 13.8 0.3 0.67 9.3 0.3 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF463 PF04317.12 EFC49707.1 - 0.035 13.0 0.0 0.049 12.6 0.0 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 AAA_24 PF13479.6 EFC49707.1 - 0.041 13.6 0.0 0.2 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 EFC49707.1 - 0.066 13.8 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 EFC49707.1 - 0.15 12.2 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC49707.1 - 0.16 12.3 0.1 0.28 11.6 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Helicase_Sgs1 PF11408.8 EFC49708.1 - 0.011 15.7 0.2 0.033 14.2 0.2 1.9 1 0 0 1 1 1 0 Sgs1 RecQ helicase RNA_pol_Rpb6 PF01192.22 EFC49708.1 - 0.072 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb6 PseudoU_synth_1 PF01416.20 EFC49709.1 - 1.3e-32 112.5 0.0 1.6e-24 86.4 0.0 2.4 2 0 0 2 2 2 2 tRNA pseudouridine synthase COMMD1_N PF17221.3 EFC49710.1 - 3.5e-11 43.3 2.5 3.5e-11 43.3 0.6 1.8 2 0 0 2 2 2 1 COMMD1 N-terminal domain COMM_domain PF07258.14 EFC49710.1 - 3e-09 36.9 4.6 5.2e-09 36.1 3.2 1.9 2 0 0 2 2 2 1 COMM domain RNase_H2_suC PF08615.11 EFC49711.1 - 5.2e-13 49.4 0.3 3.1e-10 40.4 0.0 2.1 1 1 1 2 2 2 2 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DUF4768 PF15989.5 EFC49711.1 - 0.046 13.7 0.0 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4768) Ribosomal_L37 PF08561.10 EFC49712.1 - 9.4e-09 35.8 7.2 1.6e-06 28.6 0.1 2.4 2 1 1 3 3 3 2 Mitochondrial ribosomal protein L37 Iron_permease PF04120.12 EFC49712.1 - 0.15 11.9 0.5 1.3 8.8 0.0 2.2 1 1 1 2 2 2 0 Low affinity iron permease DUF678 PF05077.12 EFC49712.1 - 1.3 9.2 6.0 2 8.6 0.5 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF678) DUF1604 PF07713.13 EFC49713.1 - 6.7e-24 83.5 6.0 6.7e-24 83.5 6.0 5.6 4 1 1 5 5 5 1 Protein of unknown function (DUF1604) G-patch PF01585.23 EFC49713.1 - 1.7e-06 27.8 0.0 6.1e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 EFC49713.1 - 0.022 14.9 0.0 0.022 14.9 0.0 4.0 4 0 0 4 4 4 0 G-patch domain DUF938 PF06080.12 EFC49714.1 - 3.5e-56 190.2 0.0 4.2e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_25 PF13649.6 EFC49714.1 - 0.0003 21.4 0.0 0.00089 19.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC49714.1 - 0.081 12.7 0.0 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Homeobox_KN PF05920.11 EFC49715.1 - 7.9e-17 60.9 1.5 2.5e-16 59.3 1.5 1.9 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 EFC49715.1 - 6.1e-05 22.8 0.2 0.00021 21.1 0.2 2.0 1 0 0 1 1 1 1 Homeodomain PQ-loop PF04193.14 EFC49717.1 - 1.6 8.6 6.3 2.7 7.8 1.7 2.7 2 1 1 3 3 3 0 PQ loop repeat ZZ PF00569.17 EFC49718.1 - 6.3e-09 35.5 10.0 1.4e-08 34.4 10.0 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type PB1 PF00564.24 EFC49718.1 - 0.022 14.7 0.1 0.045 13.7 0.1 1.5 1 0 0 1 1 1 0 PB1 domain Aconitase PF00330.20 EFC49719.1 - 8.6e-151 503.0 0.0 1.3e-150 502.4 0.0 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 EFC49719.1 - 4.2e-37 127.4 0.0 9e-37 126.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF1043 PF06295.12 EFC49719.1 - 0.49 10.4 2.8 0.8 9.7 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) HEAT PF02985.22 EFC49720.1 - 4e-05 23.5 2.5 0.016 15.4 0.0 6.3 8 0 0 8 8 8 1 HEAT repeat HEAT_2 PF13646.6 EFC49720.1 - 0.025 14.9 0.0 19 5.7 0.0 4.2 2 1 1 3 3 3 0 HEAT repeats RTP1_C1 PF10363.9 EFC49720.1 - 2.3 8.4 8.6 4.4 7.5 0.1 4.8 5 0 0 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 2OG-FeII_Oxy_3 PF13640.6 EFC49721.1 - 5.9e-12 46.3 0.0 1.1e-11 45.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 EFC49721.1 - 6.2e-08 32.1 0.0 1.1e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Poxvirus C4/C10 protein F-box-like PF12937.7 EFC49721.1 - 1.1e-07 31.6 0.1 2.5e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 F-box-like 2OG-FeII_Oxy_4 PF13661.6 EFC49721.1 - 0.00032 21.3 0.0 0.00062 20.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 EFC49721.1 - 0.013 16.0 0.0 0.029 14.8 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PRANC PF09372.10 EFC49721.1 - 0.014 15.7 0.0 0.06 13.7 0.0 2.1 2 0 0 2 2 2 0 PRANC domain F-box PF00646.33 EFC49721.1 - 0.036 14.0 0.5 0.088 12.7 0.5 1.7 1 1 0 1 1 1 0 F-box domain Vault_2 PF17794.1 EFC49721.1 - 0.08 13.3 0.0 0.25 11.7 0.0 1.8 2 0 0 2 2 2 0 Major Vault Protein repeat domain F-box_4 PF15966.5 EFC49721.1 - 0.09 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 F-box FANCL_C PF11793.8 EFC49722.1 - 0.014 15.5 0.3 0.026 14.7 0.3 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_recom PF13408.6 EFC49722.1 - 0.12 13.0 0.1 0.16 12.5 0.1 1.4 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain RGS PF00615.19 EFC49724.1 - 2.8e-09 37.2 7.1 2.8e-09 37.2 7.1 1.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain AAA-ATPase_like PF09820.9 EFC49725.1 - 2.5e-57 194.5 1.4 2.5e-57 194.5 1.4 2.8 2 1 1 3 3 3 1 Predicted AAA-ATPase PDDEXK_9 PF08011.11 EFC49725.1 - 0.0011 18.8 3.4 0.55 10.2 0.6 3.0 1 1 0 2 2 2 2 PD-(D/E)XK nuclease superfamily TetR_C_26 PF17934.1 EFC49725.1 - 0.59 10.5 3.6 10 6.5 0.9 2.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Ras PF00071.22 EFC49726.1 - 5.2e-27 94.4 0.1 6.8e-27 94.0 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49726.1 - 1.5e-13 51.0 0.0 2.7e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49726.1 - 7.2e-10 38.6 0.1 1.2e-09 37.8 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC49726.1 - 6e-06 25.9 0.1 1.6e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 EFC49726.1 - 9.5e-05 22.5 0.0 0.00021 21.4 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 EFC49726.1 - 0.00042 20.2 0.1 0.00056 19.8 0.1 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Gtr1_RagA PF04670.12 EFC49726.1 - 0.00069 19.0 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region IFRD PF05004.13 EFC49726.1 - 0.0012 18.1 0.5 0.0016 17.6 0.5 1.2 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) RsgA_GTPase PF03193.16 EFC49726.1 - 0.002 18.0 0.4 0.025 14.5 0.3 2.3 2 1 0 2 2 2 1 RsgA GTPase MeaB PF03308.16 EFC49726.1 - 0.013 14.5 0.1 0.028 13.4 0.0 1.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 EFC49726.1 - 0.034 13.3 4.3 0.069 12.3 4.3 1.6 1 1 0 1 1 1 0 G-protein alpha subunit Peptidase_M14 PF00246.24 EFC49727.1 - 5.8e-39 134.6 0.2 8.2e-39 134.1 0.2 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 EFC49727.1 - 7.4e-08 32.6 0.0 2.6e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFC49727.1 - 2.8e-06 27.2 0.0 6.7e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 CarboxypepD_reg-like domain PEGA PF08308.11 EFC49727.1 - 0.046 13.6 0.1 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 PEGA domain F-box_4 PF15966.5 EFC49728.1 - 0.064 13.1 1.1 0.12 12.2 1.1 1.6 1 1 0 1 1 1 0 F-box C_Hendra PF16821.5 EFC49729.1 - 0.041 13.8 0.1 0.056 13.3 0.1 1.2 1 0 0 1 1 1 0 C protein from hendra and measles viruses Fe-S_biosyn PF01521.20 EFC49730.1 - 1.4e-10 41.3 0.1 2.6e-10 40.5 0.1 1.4 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis SMI1_KNR4 PF09346.10 EFC49730.1 - 0.024 15.0 0.0 0.032 14.6 0.0 1.1 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) SLD3 PF08639.10 EFC49731.1 - 0.32 9.7 11.1 0.45 9.2 11.1 1.2 1 0 0 1 1 1 0 DNA replication regulator SLD3 Ndc1_Nup PF09531.10 EFC49731.1 - 4.4 5.9 13.0 6.2 5.4 13.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 EFC49731.1 - 5.1 6.9 17.6 7.9 6.3 17.6 1.2 1 0 0 1 1 1 0 SPX domain Ank_2 PF12796.7 EFC49732.1 - 0.00034 21.1 0.0 0.00088 19.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 EFC49732.1 - 0.00096 19.5 0.1 0.0049 17.2 0.0 2.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 EFC49732.1 - 0.0013 19.3 0.0 0.0035 17.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC49732.1 - 0.0056 17.1 0.0 0.039 14.5 0.0 2.5 1 0 0 1 1 1 1 Ankyrin repeat DUF1068 PF06364.12 EFC49733.1 - 0.00037 20.4 3.0 0.00071 19.5 3.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1068) DHR10 PF18595.1 EFC49733.1 - 0.0016 18.5 4.0 0.0016 18.5 4.0 2.5 2 1 1 3 3 3 1 Designed helical repeat protein 10 domain DKNYY PF13644.6 EFC49733.1 - 0.004 17.9 0.0 0.49 11.2 0.0 2.4 1 1 1 2 2 2 1 DKNYY family Not3 PF04065.15 EFC49733.1 - 0.006 16.0 7.0 0.006 16.0 7.0 2.1 3 0 0 3 3 3 1 Not1 N-terminal domain, CCR4-Not complex component ABC_tran_CTD PF16326.5 EFC49733.1 - 0.027 14.7 6.9 0.034 14.4 5.0 2.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain AJAP1_PANP_C PF15298.6 EFC49733.1 - 0.065 13.4 0.2 0.2 11.9 0.1 1.9 2 0 0 2 2 2 0 AJAP1/PANP C-terminus Peptidase_C10 PF01640.17 EFC49733.1 - 0.072 13.4 1.3 0.16 12.2 1.3 1.5 1 0 0 1 1 1 0 Peptidase C10 family DUF2316 PF10078.9 EFC49733.1 - 0.17 12.1 3.9 3.6 7.9 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) HR1 PF02185.16 EFC49733.1 - 0.24 11.5 10.5 0.094 12.8 5.6 2.9 2 1 1 3 3 3 0 Hr1 repeat DUF4407 PF14362.6 EFC49733.1 - 0.36 10.1 2.9 0.61 9.4 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4398 PF14346.6 EFC49733.1 - 0.81 10.4 4.6 9.3 7.0 1.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4398) Exonuc_VII_L PF02601.15 EFC49733.1 - 4.3 6.8 7.0 6.3 6.3 5.9 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Pkinase PF00069.25 EFC49734.1 - 3.7e-05 23.2 0.8 8.4e-05 22.1 0.8 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49734.1 - 0.0016 17.8 0.3 0.0041 16.4 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase KAR PF15222.6 EFC49734.1 - 0.027 14.8 0.2 0.22 11.8 0.1 2.4 2 0 0 2 2 2 0 Kidney androgen-regulated TPR_2 PF07719.17 EFC49735.1 - 0.096 12.8 2.0 26 5.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Urocanase PF01175.18 EFC49737.1 - 1.1e-85 286.6 0.0 1.7e-85 285.9 0.0 1.4 1 0 0 1 1 1 1 Urocanase Rossmann-like domain Urocanase_C PF17392.2 EFC49737.1 - 2.6e-83 278.3 0.3 4.1e-83 277.6 0.3 1.3 1 0 0 1 1 1 1 Urocanase C-terminal domain Urocanase_N PF17391.2 EFC49737.1 - 4.3e-53 178.4 0.2 1.5e-52 176.6 0.1 1.9 2 0 0 2 2 2 1 Urocanase N-terminal domain MoaF_C PF17409.2 EFC49737.1 - 0.15 11.7 0.1 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 MoaF C-terminal domain BAR PF03114.18 EFC49738.1 - 1.5e-21 77.1 8.8 2.2e-21 76.6 8.8 1.1 1 0 0 1 1 1 1 BAR domain GYF_2 PF14237.6 EFC49738.1 - 6.1e-13 48.4 0.1 1.1e-12 47.5 0.1 1.5 1 0 0 1 1 1 1 GYF domain 2 Vps5 PF09325.10 EFC49738.1 - 1.2e-10 41.3 2.3 2.5e-10 40.3 2.3 1.5 1 0 0 1 1 1 1 Vps5 C terminal like Golgin_A5 PF09787.9 EFC49738.1 - 0.0015 18.0 7.0 0.025 14.0 0.1 2.1 2 0 0 2 2 2 2 Golgin subfamily A member 5 Arfaptin PF06456.13 EFC49738.1 - 0.035 13.7 11.8 0.093 12.3 10.7 2.2 1 1 1 2 2 2 0 Arfaptin-like domain GYF PF02213.16 EFC49738.1 - 0.046 13.4 0.4 0.088 12.5 0.4 1.5 1 0 0 1 1 1 0 GYF domain LLC1 PF14945.6 EFC49738.1 - 0.11 13.0 3.1 0.18 12.4 1.9 1.9 1 1 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein PRANC PF09372.10 EFC49738.1 - 0.48 10.8 2.8 1.4 9.3 2.1 2.1 1 1 1 2 2 2 0 PRANC domain STAG PF08514.11 EFC49738.1 - 1.1 9.2 8.8 0.14 12.1 2.1 2.6 2 1 1 3 3 3 0 STAG domain Myb_DNA-bind_3 PF12776.7 EFC49738.1 - 1.2 10.2 6.6 2.5 9.2 1.8 2.8 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain GrpE PF01025.19 EFC49738.1 - 2 8.0 8.0 2.5 7.7 1.9 2.4 2 0 0 2 2 2 0 GrpE TMPIT PF07851.13 EFC49738.1 - 3.1 6.9 9.7 3.8 6.7 5.2 2.2 2 0 0 2 2 2 0 TMPIT-like protein RCC1 PF00415.18 EFC49740.1 - 2.2e-08 34.6 0.2 0.046 14.3 0.0 4.2 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC49740.1 - 5.5e-07 29.2 3.5 2.4e-05 24.0 0.1 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat LRR_8 PF13855.6 EFC49741.1 - 1.9e-18 66.0 30.0 2.8e-08 33.4 4.5 5.3 2 1 4 6 6 6 6 Leucine rich repeat LRR_6 PF13516.6 EFC49741.1 - 4.4e-17 60.6 24.8 0.011 15.7 0.1 9.0 9 0 0 9 9 9 5 Leucine Rich repeat LRR_4 PF12799.7 EFC49741.1 - 7.1e-13 48.5 41.9 0.00037 20.8 1.9 5.9 2 2 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC49741.1 - 0.0059 16.1 18.5 0.56 9.7 1.5 3.7 1 1 3 4 4 4 4 Leucine-rich repeat DUF2100 PF09873.9 EFC49741.1 - 0.054 13.4 0.0 0.054 13.4 0.0 2.6 3 1 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2100) LRR_1 PF00560.33 EFC49741.1 - 0.28 11.9 25.9 23 6.0 0.2 8.5 10 0 0 10 10 10 0 Leucine Rich Repeat Beta_helix PF13229.6 EFC49741.1 - 7.4 6.4 16.9 0.15 11.9 9.1 2.0 2 0 0 2 2 2 0 Right handed beta helix region Tyr-DNA_phospho PF06087.12 EFC49742.1 - 1.1e-53 182.6 2.8 1.4e-53 182.4 2.8 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 EFC49742.1 - 0.0044 16.9 4.0 0.22 11.4 0.6 2.9 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 EFC49742.1 - 0.042 14.0 0.5 11 6.3 0.1 3.5 3 0 0 3 3 3 0 Phospholipase D Active site motif SMC_N PF02463.19 EFC49743.1 - 5.5e-45 153.5 76.1 1.3e-44 152.3 76.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 EFC49743.1 - 9.1e-31 106.6 0.2 5.3e-30 104.1 0.1 2.5 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.6 EFC49743.1 - 6.1e-08 32.8 30.4 6.1e-08 32.8 30.4 5.3 2 2 1 3 3 1 1 AAA ATPase domain AAA_21 PF13304.6 EFC49743.1 - 7e-08 32.6 0.2 7e-08 32.6 0.2 5.5 2 2 1 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 EFC49743.1 - 6e-07 29.1 0.0 1.3e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tropomyosin_1 PF12718.7 EFC49743.1 - 0.001 19.3 7.3 0.001 19.3 7.3 8.7 2 2 7 10 10 10 1 Tropomyosin like PspA_IM30 PF04012.12 EFC49743.1 - 0.0014 18.2 20.3 0.0014 18.2 20.3 7.2 5 2 2 7 7 7 1 PspA/IM30 family SbcCD_C PF13558.6 EFC49743.1 - 0.0048 17.1 0.0 0.086 13.1 0.0 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 EFC49743.1 - 0.082 13.2 1.6 16 5.7 0.0 4.2 3 0 0 3 3 3 0 AAA domain Spc7 PF08317.11 EFC49743.1 - 1.7 7.5 148.2 0.0082 15.1 10.9 6.5 2 2 3 6 6 6 0 Spc7 kinetochore protein LPP PF04728.13 EFC49743.1 - 5.3 7.5 28.6 7.9 7.0 1.6 8.1 7 1 0 8 8 8 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 EFC49743.1 - 7.2 5.9 97.8 2.1 7.6 9.7 6.3 4 1 2 6 6 6 0 Domain of unknown function (DUF4407) Mito_carr PF00153.27 EFC49744.1 - 1.8e-75 249.0 0.7 1.3e-25 89.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 EFC49744.1 - 0.02 15.1 0.0 6.4 7.1 0.0 2.6 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase WD40 PF00400.32 EFC49745.1 - 6.4e-25 86.9 8.4 6.8e-07 29.9 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49745.1 - 6e-08 32.9 1.3 0.021 15.1 0.0 5.2 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC49745.1 - 1e-06 28.3 11.0 6.8e-06 25.6 6.7 2.5 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 EFC49745.1 - 0.002 16.8 1.6 0.2 10.3 0.4 2.4 2 1 0 2 2 2 2 Nucleoporin Nup120/160 PQQ PF01011.21 EFC49745.1 - 0.0039 17.0 0.1 2.5 8.2 0.0 2.8 2 0 0 2 2 2 2 PQQ enzyme repeat PALB2_WD40 PF16756.5 EFC49745.1 - 0.066 12.1 0.2 2.9 6.7 0.1 2.8 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Wzy_C PF04932.15 EFC49746.1 - 0.2 11.3 3.7 0.43 10.2 2.2 2.0 2 0 0 2 2 2 0 O-Antigen ligase EI24 PF07264.11 EFC49746.1 - 0.21 11.8 9.1 0.03 14.6 4.4 1.8 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) VIT1 PF01988.19 EFC49746.1 - 0.34 10.7 7.8 0.16 11.8 4.6 1.7 1 1 0 2 2 2 0 VIT family TMEM223 PF14640.6 EFC49746.1 - 0.44 10.7 2.6 2.5 8.3 0.5 2.5 1 1 1 2 2 2 0 Transmembrane protein 223 DUF2615 PF11027.8 EFC49746.1 - 0.72 10.0 2.6 25 5.0 0.4 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF2615) RWP-RK PF02042.15 EFC49747.1 - 1.2e-15 57.2 0.2 2.3e-15 56.3 0.2 1.5 1 0 0 1 1 1 1 RWP-RK domain RTBV_P12 PF06361.11 EFC49747.1 - 0.11 12.9 0.2 0.39 11.1 0.2 2.0 1 0 0 1 1 1 0 Rice tungro bacilliform virus P12 protein Glyco_hydro_67M PF07488.12 EFC49747.1 - 0.11 11.5 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 middle domain PARG_cat PF05028.14 EFC49748.1 - 6.1e-77 259.2 3.1 3.4e-55 187.7 0.4 2.2 2 0 0 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) DUF3573 PF12097.8 EFC49749.1 - 0.058 12.2 0.0 0.062 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) TFA2_Winged_2 PF18121.1 EFC49749.1 - 0.058 13.1 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 DUF4407 PF14362.6 EFC49749.1 - 0.079 12.3 0.1 0.13 11.6 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FH2 PF02181.23 EFC49750.1 - 1e-68 232.2 17.5 1e-68 232.2 17.5 3.7 4 0 0 4 4 4 2 Formin Homology 2 Domain DUF3361 PF11841.8 EFC49750.1 - 4.1e-10 39.8 0.5 4.1e-10 39.8 0.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) DUF948 PF06103.11 EFC49750.1 - 0.033 14.4 8.6 0.58 10.5 1.6 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) zf-C4H2 PF10146.9 EFC49750.1 - 0.049 13.9 0.3 0.049 13.9 0.3 3.0 3 0 0 3 3 3 0 Zinc finger-containing protein Laminin_II PF06009.12 EFC49750.1 - 0.74 9.8 12.6 1.4 9.0 0.5 3.0 2 0 0 2 2 2 0 Laminin Domain II DASH_Duo1 PF08651.10 EFC49750.1 - 0.93 9.3 9.1 0.99 9.2 0.1 3.5 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF3810 PF12725.7 EFC49750.1 - 1.1 8.5 7.6 0.34 10.2 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF1664 PF07889.12 EFC49750.1 - 3.3 7.8 16.9 0.9 9.6 1.1 4.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) JAB PF01398.21 EFC49751.1 - 2.9e-23 82.1 0.0 3.4e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 EFC49751.1 - 6.5e-10 38.8 0.0 7.7e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 EFC49751.1 - 6.2e-05 23.1 0.0 6.8e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Bystin PF05291.11 EFC49754.1 - 1.4e-87 293.8 4.2 2.3e-87 293.0 4.2 1.4 1 1 0 1 1 1 1 Bystin Methyltransf_12 PF08242.12 EFC49755.1 - 0.069 13.9 0.3 1.4 9.7 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain DUF2235 PF09994.9 EFC49755.1 - 0.25 10.6 2.4 0.69 9.2 2.3 1.8 1 1 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Actin PF00022.19 EFC49757.1 - 2.5e-121 405.1 0.0 4e-120 401.1 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC49757.1 - 0.12 11.2 0.0 0.25 10.1 0.0 1.6 1 1 0 1 1 1 0 MreB/Mbl protein NmrA PF05368.13 EFC49758.1 - 2.2e-12 47.0 0.1 3.6e-12 46.3 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 EFC49758.1 - 4.4e-10 39.7 0.0 6.1e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding GTP_EFTU PF00009.27 EFC49759.1 - 0.00018 21.1 0.0 0.00055 19.5 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.18 EFC49759.1 - 0.0002 20.7 0.5 0.00036 19.9 0.0 1.6 2 0 0 2 2 2 1 Septin T2SSE PF00437.20 EFC49759.1 - 0.0022 17.1 0.1 0.0034 16.5 0.1 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 EFC49759.1 - 0.0026 17.8 0.0 0.0053 16.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 EFC49759.1 - 0.006 17.1 0.0 0.015 15.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 EFC49759.1 - 0.07 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 EFC49759.1 - 0.099 11.8 0.0 0.21 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 EFC49760.1 - 0.0035 17.6 0.0 0.024 14.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC49760.1 - 0.0074 16.7 0.0 0.019 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF5601 PF18151.1 EFC49760.1 - 3.1 8.2 5.5 3.2 8.1 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF5601) Diphthamide_syn PF01866.17 EFC49761.1 - 7e-115 383.6 0.0 9.7e-115 383.2 0.0 1.2 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Swi5 PF07061.11 EFC49762.1 - 0.017 15.2 3.7 0.02 15.0 3.7 1.2 1 0 0 1 1 1 0 Swi5 MRP-L51 PF10244.9 EFC49762.1 - 0.073 13.3 1.6 0.073 13.3 1.6 1.0 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit ABC2_membrane PF01061.24 EFC49763.1 - 3.8e-15 55.9 14.8 3.8e-15 55.9 14.8 2.6 3 0 0 3 3 3 1 ABC-2 type transporter TMEM52 PF14979.6 EFC49763.1 - 0.029 14.3 0.2 0.072 13.0 0.2 1.7 1 0 0 1 1 1 0 Transmembrane 52 Dpy-30 PF05186.13 EFC49763.1 - 0.039 13.7 0.0 0.11 12.2 0.0 1.8 1 0 0 1 1 1 0 Dpy-30 motif PDR_CDR PF06422.12 EFC49763.1 - 0.087 12.7 0.7 16 5.5 0.1 3.0 2 0 0 2 2 2 0 CDR ABC transporter DUF4577 PF15145.6 EFC49763.1 - 0.15 12.1 0.1 0.66 10.0 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) ETRAMP PF09716.10 EFC49763.1 - 0.21 11.7 1.7 0.68 10.0 0.2 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) COX2_TM PF02790.15 EFC49763.1 - 0.34 11.1 3.2 0.24 11.6 0.1 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4834 PF16118.5 EFC49763.1 - 0.65 11.0 6.2 5.6 8.0 0.2 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) ABC2_membrane_3 PF12698.7 EFC49763.1 - 1.5 7.8 30.4 0.0089 15.2 14.2 3.8 4 0 0 4 4 4 0 ABC-2 family transporter protein TMEM154 PF15102.6 EFC49763.1 - 1.7 8.6 5.2 1.2 9.1 0.1 3.2 3 0 0 3 3 3 0 TMEM154 protein family OAD_gamma PF04277.13 EFC49763.1 - 2.8 8.6 5.2 14 6.4 0.7 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Guanylate_cyc PF00211.20 EFC49764.1 - 5.2e-55 185.9 1.5 6.7e-55 185.6 0.1 2.0 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC49764.1 - 1.1e-13 51.3 0.0 4.2e-13 49.4 0.0 2.1 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 EFC49764.1 - 3.9e-09 36.5 0.0 9.6e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC49764.1 - 0.00063 19.7 0.0 0.0026 17.7 0.0 2.0 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC49764.1 - 0.014 15.7 0.0 0.032 14.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold HNOBA PF07701.14 EFC49764.1 - 0.38 10.2 6.3 0.05 13.0 0.7 2.4 3 0 0 3 3 3 0 Heme NO binding associated Mito_carr PF00153.27 EFC49765.1 - 1.7e-12 47.1 0.1 3e-08 33.5 0.0 2.6 1 1 0 2 2 2 2 Mitochondrial carrier protein IFT43 PF15305.6 EFC49766.1 - 7e-34 116.9 0.3 7e-34 116.9 0.3 1.4 2 0 0 2 2 2 1 Intraflagellar transport protein 43 DUF3342 PF11822.8 EFC49767.1 - 2.5e-28 98.1 1.4 2.5e-28 98.1 1.4 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3342) DUF2120 PF09893.9 EFC49767.1 - 0.07 13.2 1.3 2.3 8.3 0.1 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) ESCRT-II PF05871.12 EFC49767.1 - 0.09 13.0 0.3 0.24 11.6 0.3 1.7 1 0 0 1 1 1 0 ESCRT-II complex subunit FRD2 PF03197.13 EFC49767.1 - 1.7 9.0 8.2 0.094 13.0 0.8 2.7 2 1 1 3 3 3 0 Bacteriophage FRD2 protein TFIIA PF03153.13 EFC49769.1 - 1.1 9.2 14.1 1.7 8.6 14.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Proteasome PF00227.26 EFC49770.1 - 6.3e-38 130.2 0.1 7.1e-38 130.0 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit Cwf_Cwc_15 PF04889.12 EFC49771.1 - 3.6e-41 141.5 32.1 8.5e-41 140.3 32.1 1.6 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Mso1_Sec1_bdg PF14475.6 EFC49771.1 - 2.6 7.7 8.1 1.8 8.2 3.8 2.5 2 0 0 2 2 2 0 Sec1-binding region of Mso1 TPR_12 PF13424.6 EFC49772.1 - 1.5e-22 79.7 10.5 4.4e-07 30.1 0.0 5.7 3 1 3 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49772.1 - 5.1e-08 32.4 10.5 0.81 9.9 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49772.1 - 7.8e-07 28.8 18.5 0.73 10.2 0.7 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49772.1 - 4.6e-06 26.2 16.2 1 9.3 0.0 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat SNAP PF14938.6 EFC49772.1 - 4.8e-06 26.2 5.5 0.0022 17.5 0.2 3.4 2 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 EFC49772.1 - 1e-05 25.2 3.8 0.022 14.6 0.1 4.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49772.1 - 0.0013 19.2 0.6 12 6.4 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat YfdX PF10938.8 EFC49772.1 - 0.0036 17.2 1.2 4.3 7.3 0.0 3.7 4 0 0 4 4 4 1 YfdX protein SPO22 PF08631.10 EFC49772.1 - 0.032 13.7 1.8 0.37 10.2 0.1 2.4 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_7 PF13176.6 EFC49772.1 - 0.051 13.6 11.1 4.8 7.5 0.1 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC49772.1 - 0.11 12.8 5.3 6.7 7.0 0.2 4.4 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 EFC49772.1 - 6.8 6.4 13.1 0.46 10.2 2.0 3.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 EFC49772.1 - 8.4 6.2 13.0 18 5.1 0.1 4.7 5 0 0 5 5 5 0 TPR repeat LsmAD PF06741.13 EFC49773.1 - 1.5e-24 86.3 0.6 6.5e-24 84.3 0.6 2.2 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 EFC49773.1 - 3.3e-16 59.2 0.3 3.3e-16 59.2 0.3 2.2 2 0 0 2 2 2 1 Ataxin 2 SM domain PAM2 PF07145.15 EFC49773.1 - 0.004 16.7 2.0 0.004 16.7 2.0 2.8 2 1 1 3 3 3 1 Ataxin-2 C-terminal region Zip PF02535.22 EFC49773.1 - 1.1 8.4 11.8 1.4 8.1 6.2 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter WD-3 PF09765.9 EFC49774.1 - 1.2e-34 119.9 1.0 1.5e-34 119.7 1.0 1.1 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 EFC49774.1 - 1.7e-27 95.4 4.0 3e-27 94.6 4.0 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 EFC49774.1 - 0.00011 22.5 5.2 0.00011 22.5 5.2 1.8 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EFC49774.1 - 0.0097 16.2 3.2 0.021 15.1 3.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain Holin_BhlA PF10960.8 EFC49774.1 - 0.026 14.5 0.4 0.045 13.7 0.4 1.3 1 0 0 1 1 1 0 BhlA holin family zf-ANAPC11 PF12861.7 EFC49774.1 - 0.056 13.5 3.4 0.12 12.4 3.4 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 EFC49774.1 - 0.17 12.0 3.2 0.41 10.8 3.2 1.7 1 1 0 1 1 1 0 KIAA1045 RING finger TPR_8 PF13181.6 EFC49775.1 - 3e-11 42.6 1.3 0.0078 16.4 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49775.1 - 2.4e-08 33.4 0.1 0.02 15.0 0.0 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49775.1 - 4.1e-08 32.7 0.0 0.014 15.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49775.1 - 5.7e-07 29.8 0.0 1.3 9.8 0.0 4.2 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49775.1 - 6.4e-07 29.8 0.0 0.018 15.6 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49775.1 - 2.8e-06 27.5 0.0 0.05 13.9 0.0 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat SPO22 PF08631.10 EFC49775.1 - 0.0003 20.4 1.1 0.23 10.9 0.1 2.9 1 1 0 2 2 2 2 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 EFC49775.1 - 0.00094 19.8 0.0 5.1 8.2 0.0 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC49775.1 - 0.0017 18.2 0.3 1.9 8.7 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC49775.1 - 0.0017 18.1 0.1 0.54 10.2 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFC49775.1 - 0.0058 15.9 0.0 0.2 10.9 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF4919 PF16266.5 EFC49775.1 - 0.0075 16.2 0.6 3.5 7.5 0.2 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4919) ANAPC3 PF12895.7 EFC49775.1 - 0.0078 16.4 0.1 13 6.1 0.0 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 EFC49775.1 - 0.018 14.4 0.1 2.9 7.2 0.2 2.5 1 1 2 3 3 3 0 MalT-like TPR region TPR_17 PF13431.6 EFC49775.1 - 0.024 15.0 0.0 18 6.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49775.1 - 0.067 13.9 0.0 8.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Ndc1_Nup PF09531.10 EFC49776.1 - 0.029 13.1 0.7 0.022 13.5 0.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RP-C_C PF11800.8 EFC49776.1 - 0.28 11.3 2.1 0.46 10.5 2.1 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region SPATA3 PF15662.5 EFC49776.1 - 3.8 8.1 12.3 5.7 7.5 12.3 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family FancD2 PF14631.6 EFC49776.1 - 5 4.4 6.2 6.7 4.0 6.2 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Acetyltransf_3 PF13302.7 EFC49777.1 - 4.8e-05 24.1 0.0 8.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC49777.1 - 0.00037 20.8 0.0 0.00083 19.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC49777.1 - 0.0018 18.2 0.0 0.0065 16.4 0.0 1.9 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 EFC49777.1 - 0.0022 18.2 0.0 0.0057 16.9 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_13 PF13880.6 EFC49777.1 - 0.012 15.6 0.0 0.034 14.1 0.0 1.8 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase MutS_V PF00488.21 EFC49778.1 - 6.1e-75 251.4 0.2 1.9e-74 249.8 0.2 1.9 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 EFC49778.1 - 4.4e-32 111.9 3.2 4.4e-32 111.9 3.2 2.7 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 EFC49778.1 - 2e-29 102.1 0.2 6.8e-29 100.4 0.2 2.0 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 EFC49778.1 - 1.9e-08 34.7 0.1 1.9e-08 34.7 0.1 2.6 2 0 0 2 2 2 1 MutS domain II UPF0489 PF12640.7 EFC49778.1 - 7.3e-07 29.6 3.5 8.3e-06 26.1 0.0 3.7 3 1 0 3 3 3 1 UPF0489 domain DUF913 PF06025.12 EFC49778.1 - 0.67 8.9 10.2 1.6 7.6 10.2 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Pkinase PF00069.25 EFC49779.1 - 2.5e-15 56.6 1.8 3e-15 56.3 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49779.1 - 2.2e-06 27.2 0.0 4.7e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 EFC49779.1 - 0.011 15.4 0.1 0.031 13.9 0.1 1.8 1 0 0 1 1 1 0 RIO1 family GST_N_3 PF13417.6 EFC49780.1 - 3.8e-15 56.0 0.0 7.6e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC49780.1 - 6.4e-15 55.1 0.0 9.9e-15 54.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC49780.1 - 1.7e-14 53.9 0.0 3e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 EFC49780.1 - 8.7e-12 45.2 0.0 1.5e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC49780.1 - 1.5e-07 31.5 0.0 3e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC49780.1 - 6.9e-05 22.8 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_5 PF18485.1 EFC49780.1 - 0.081 13.3 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain eIF-1a PF01176.19 EFC49781.1 - 2.2e-21 75.4 0.1 3.2e-21 74.9 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 HupH_C PF04809.13 EFC49781.1 - 0.1 12.3 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 HupH hydrogenase expression protein, C-terminal conserved region DUF1624 PF07786.12 EFC49782.1 - 0.0021 17.6 0.1 0.0021 17.6 0.1 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1624) DUF2721 PF11026.8 EFC49782.1 - 1.2 9.0 6.7 0.85 9.5 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF5009 PF16401.5 EFC49782.1 - 7.1 6.0 15.4 87 2.5 15.4 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5009) WD40 PF00400.32 EFC49783.1 - 8.7e-13 48.5 11.1 1.2e-06 29.1 0.1 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat WD40_like PF17005.5 EFC49783.1 - 5e-08 32.6 0.8 0.039 13.3 0.1 3.8 1 1 2 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 EFC49783.1 - 3.2e-06 27.4 0.0 0.023 15.0 0.0 3.9 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PUF PF00806.19 EFC49784.1 - 2.2e-14 52.2 14.0 0.0029 17.2 0.0 8.3 8 1 0 8 8 8 5 Pumilio-family RNA binding repeat Kinesin PF00225.23 EFC49785.1 - 6.9e-106 353.9 1.0 6.9e-106 353.9 1.0 2.7 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 EFC49785.1 - 5.2e-46 156.3 0.4 5.2e-46 156.3 0.4 3.1 2 1 1 3 3 3 1 Microtubule binding SH3_1 PF00018.28 EFC49785.1 - 1.1e-10 41.0 0.1 2.1e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFC49785.1 - 2.1e-09 37.1 0.0 4e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFC49785.1 - 3.7e-07 29.7 0.0 8.9e-07 28.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain TolA_bind_tri PF16331.5 EFC49785.1 - 0.0029 17.7 4.0 0.0029 17.7 4.0 3.8 3 1 2 5 5 5 1 TolA binding protein trimerisation Baculo_PEP_C PF04513.12 EFC49785.1 - 0.12 12.4 5.3 0.11 12.5 2.6 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FAM76 PF16046.5 EFC49785.1 - 2.3 7.5 37.3 11 5.3 35.7 2.3 1 1 1 2 2 2 0 FAM76 protein Glyco_trans_1_4 PF13692.6 EFC49786.1 - 3.5e-09 37.2 0.0 1.5e-08 35.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 EFC49786.1 - 6.1e-09 35.6 0.0 1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 EFC49786.1 - 0.00074 19.6 0.0 0.0025 17.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase Family 4 RsgA_GTPase PF03193.16 EFC49787.1 - 0.0046 16.9 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 EFC49787.1 - 0.0062 16.9 0.0 0.017 15.5 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 EFC49787.1 - 0.008 16.7 0.2 0.02 15.4 0.2 1.6 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 EFC49787.1 - 0.026 14.8 0.0 0.41 10.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain LRR_6 PF13516.6 EFC49788.1 - 2e-41 136.5 26.2 8.9e-05 22.3 0.1 12.3 12 0 0 12 12 12 10 Leucine Rich repeat LRR_8 PF13855.6 EFC49788.1 - 2e-21 75.5 25.9 1.3e-06 28.1 2.9 6.2 2 2 4 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC49788.1 - 5e-21 74.4 28.3 0.00057 20.2 0.1 7.8 2 2 5 9 9 9 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC49788.1 - 1.2e-12 46.5 9.1 9.1 7.3 0.0 10.3 11 1 0 11 11 11 2 Leucine Rich Repeat LRR_9 PF14580.6 EFC49788.1 - 8.1e-09 35.2 5.4 0.00079 19.0 0.5 4.0 1 1 3 4 4 4 3 Leucine-rich repeat DUF4347 PF14252.6 EFC49788.1 - 1.5e-07 31.4 5.0 1.7 8.5 0.0 5.4 1 1 6 7 7 7 3 Domain of unknown function (DUF4347) GAD PF02938.14 EFC49788.1 - 0.42 10.9 2.2 13 6.1 0.1 3.7 4 1 1 5 5 5 0 GAD domain DUF1041 PF06292.17 EFC49788.1 - 0.58 10.6 3.8 5 7.6 0.2 3.3 2 1 0 3 3 3 0 Domain of Unknown Function (DUF1041) YdiH PF15930.5 EFC49788.1 - 1.8 8.8 6.8 64 3.8 0.0 5.2 5 2 1 6 6 6 0 Domain of unknown function WD40 PF00400.32 EFC49789.1 - 1.8e-21 76.0 16.5 4.9e-05 24.0 0.0 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat PRP4 PF08799.11 EFC49789.1 - 3.3e-13 48.9 1.7 9.2e-13 47.5 1.7 1.8 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 EFC49789.1 - 0.0013 19.0 0.0 0.16 12.3 0.0 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain MitMem_reg PF13012.6 EFC49789.1 - 0.055 13.9 0.1 0.12 12.8 0.1 1.6 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function Glyco_hydro_45 PF02015.16 EFC49789.1 - 0.09 12.7 0.2 0.15 11.9 0.2 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 DUF4404 PF14357.6 EFC49789.1 - 0.64 10.7 4.6 1 10.0 3.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) T2SSF PF00482.23 EFC49790.1 - 2.1e-12 47.1 1.6 4.1e-05 23.5 0.1 2.4 2 0 0 2 2 2 2 Type II secretion system (T2SS), protein F UPF0302 PF08864.10 EFC49790.1 - 0.0086 16.1 2.2 1.3 9.1 0.1 3.2 3 0 0 3 3 3 2 UPF0302 domain RNA_polI_A34 PF08208.11 EFC49791.1 - 3.3e-05 24.1 59.5 3.3e-05 24.1 59.5 5.4 2 2 3 5 5 5 1 DNA-directed RNA polymerase I subunit RPA34.5 DUF3112 PF11309.8 EFC49792.1 - 2 7.8 6.7 0.58 9.6 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) TPR_14 PF13428.6 EFC49793.1 - 4e-11 42.8 1.5 0.0079 16.9 0.0 4.3 2 1 3 5 5 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49793.1 - 5.2e-10 38.7 8.1 0.0024 17.9 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49793.1 - 5.8e-10 39.6 0.2 0.0024 18.5 0.1 3.6 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49793.1 - 7.3e-10 39.0 6.0 0.00022 21.4 0.2 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49793.1 - 2.6e-08 34.3 5.7 0.0029 18.1 0.9 3.5 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49793.1 - 4.7e-07 29.5 15.8 0.0047 17.0 0.1 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49793.1 - 4.4e-06 27.0 3.0 0.066 13.9 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC49793.1 - 0.00013 22.1 1.4 0.00013 22.1 1.4 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 EFC49793.1 - 0.00038 20.2 11.4 0.16 11.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_15 PF13429.6 EFC49793.1 - 0.0007 18.9 1.5 0.0012 18.1 1.5 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49793.1 - 0.00073 19.2 13.5 0.038 13.7 2.5 3.9 4 0 0 4 4 4 2 TPR repeat TPR_7 PF13176.6 EFC49793.1 - 0.00093 19.1 3.4 2.6 8.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49793.1 - 0.00097 19.4 13.2 0.18 12.3 0.1 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC49793.1 - 0.0012 18.9 0.4 0.47 10.6 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC49793.1 - 0.0049 16.7 2.4 2.5 8.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_20 PF14561.6 EFC49793.1 - 0.012 15.9 0.6 0.95 9.8 0.2 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat PRP8_domainIV PF12134.8 EFC49793.1 - 0.027 14.1 0.0 0.048 13.3 0.0 1.5 1 1 0 1 1 1 0 PRP8 domain IV core NARP1 PF12569.8 EFC49793.1 - 0.034 13.1 6.9 0.35 9.7 3.7 2.1 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 TPR_21 PF09976.9 EFC49793.1 - 0.035 13.8 0.3 0.35 10.6 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain BTAD PF03704.17 EFC49793.1 - 0.041 14.3 0.2 0.2 12.1 0.1 2.1 1 1 0 1 1 1 0 Bacterial transcriptional activator domain PknG_TPR PF16918.5 EFC49793.1 - 0.044 12.5 0.0 0.073 11.8 0.0 1.3 1 1 0 1 1 1 0 Protein kinase G tetratricopeptide repeat RPN7 PF10602.9 EFC49793.1 - 0.14 11.8 4.9 19 4.9 0.6 3.2 2 1 1 3 3 3 0 26S proteasome subunit RPN7 PPR PF01535.20 EFC49794.1 - 0.012 15.8 2.3 0.31 11.4 0.0 3.8 4 0 0 4 4 4 0 PPR repeat PPR_2 PF13041.6 EFC49794.1 - 0.016 15.4 1.0 11 6.3 0.0 3.8 3 1 1 4 4 4 0 PPR repeat family PPR_3 PF13812.6 EFC49794.1 - 0.022 14.8 0.2 8.2 6.6 0.0 2.7 2 0 0 2 2 2 0 Pentatricopeptide repeat domain TPR_2 PF07719.17 EFC49794.1 - 0.14 12.4 0.2 0.14 12.4 0.2 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49794.1 - 0.93 9.9 3.8 8.2 6.9 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat ASC PF00858.24 EFC49795.1 - 0.036 13.0 0.9 0.044 12.7 0.9 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel DUF2408 PF10303.9 EFC49795.1 - 0.084 13.4 1.5 0.63 10.6 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) VWA PF00092.28 EFC49796.1 - 2.1e-17 63.9 1.8 3.1e-17 63.4 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC49796.1 - 4.2e-15 56.3 0.7 2.1e-14 54.0 0.0 2.4 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC49796.1 - 9.2e-05 22.4 0.0 0.00026 20.9 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Fas_alpha_ACP PF18325.1 EFC49796.1 - 0.017 15.5 0.2 0.036 14.4 0.2 1.5 1 0 0 1 1 1 0 Fatty acid synthase subunit alpha Acyl carrier domain DUF1194 PF06707.11 EFC49796.1 - 0.024 13.9 0.1 0.38 9.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) VWA_CoxE PF05762.14 EFC49796.1 - 0.046 13.1 0.1 0.18 11.2 0.1 1.8 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein DNA_repr_REX1B PF14966.6 EFC49797.1 - 3e-10 40.6 5.1 1.9e-09 38.1 2.5 3.1 2 1 2 4 4 4 2 DNA repair REX1-B APG6_N PF17675.1 EFC49797.1 - 0.0016 19.0 11.7 0.0016 19.0 11.7 1.9 1 1 1 2 2 2 1 Apg6 coiled-coil region DUF2524 PF10732.9 EFC49797.1 - 0.6 10.4 9.5 0.32 11.3 1.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) DnaJ PF00226.31 EFC49798.1 - 4.7e-17 61.9 0.0 1.7e-16 60.1 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain UPF0139 PF03669.13 EFC49798.1 - 0.25 11.2 2.6 0.44 10.4 1.2 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) Oxidored_molyb PF00174.19 EFC49799.1 - 2.6e-56 190.0 0.0 4e-56 189.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 EFC49799.1 - 1.3e-35 122.4 0.3 2.3e-35 121.6 0.3 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain HCBP_related PF06594.11 EFC49799.1 - 0.033 14.1 0.5 0.076 13.0 0.5 1.7 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain BNR PF02012.20 EFC49799.1 - 0.2 11.8 1.7 0.72 10.1 1.7 2.0 1 0 0 1 1 1 0 BNR/Asp-box repeat YqzH PF14164.6 EFC49799.1 - 0.24 11.5 0.8 0.77 9.9 0.8 1.9 1 0 0 1 1 1 0 YqzH-like protein EF_TS PF00889.19 EFC49800.1 - 1.2e-44 152.5 5.5 2e-44 151.7 5.5 1.4 1 0 0 1 1 1 1 Elongation factor TS Peroxin-3 PF04882.12 EFC49800.1 - 0.0034 16.5 0.7 0.0034 16.5 0.7 1.4 1 1 0 1 1 1 1 Peroxin-3 U1snRNP70_N PF12220.8 EFC49800.1 - 0.023 15.3 0.1 0.023 15.3 0.1 2.4 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3512 PF12024.8 EFC49800.1 - 0.044 13.3 0.1 0.044 13.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3512) NIL PF09383.10 EFC49800.1 - 0.058 13.2 0.1 0.22 11.4 0.0 2.0 2 0 0 2 2 2 0 NIL domain Pro-kuma_activ PF09286.11 EFC49800.1 - 0.073 13.4 0.5 0.79 10.0 0.0 2.6 4 0 0 4 4 4 0 Pro-kumamolisin, activation domain Ponericin PF07442.11 EFC49800.1 - 0.28 11.2 1.7 0.65 10.1 1.7 1.6 1 0 0 1 1 1 0 Ponericin DUF2408 PF10303.9 EFC49800.1 - 8.3 7.0 8.8 13 6.3 1.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) dsrm PF00035.26 EFC49801.1 - 1.5e-09 38.4 0.2 3.1e-09 37.4 0.2 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonucleas_3_3 PF14622.6 EFC49801.1 - 1.1e-06 28.8 0.2 0.002 18.3 0.0 2.7 3 0 0 3 3 3 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EFC49801.1 - 1.3e-06 29.0 0.1 3.9e-06 27.4 0.1 2.0 1 1 0 1 1 1 1 Ribonuclease III domain Ribonuc_L-PSP PF01042.21 EFC49802.1 - 2.1e-31 108.5 0.0 2.5e-31 108.2 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP LMBR1 PF04791.16 EFC49803.1 - 2.1e-58 198.5 34.1 3.1e-58 198.0 34.1 1.3 1 0 0 1 1 1 1 LMBR1-like membrane protein RFC1 PF08519.12 EFC49803.1 - 0.01 16.0 0.3 0.028 14.6 0.3 1.7 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Ras PF00071.22 EFC49804.1 - 7.8e-50 168.6 0.0 9.7e-50 168.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49804.1 - 1.4e-30 106.0 0.0 3.2e-30 104.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49804.1 - 1.3e-10 41.0 0.1 1.9e-10 40.5 0.0 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC49804.1 - 0.00048 19.5 0.0 0.00081 18.8 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 EFC49804.1 - 0.0014 17.9 1.4 0.14 11.3 0.1 2.8 2 1 1 3 3 3 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC49804.1 - 0.0043 17.1 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC49804.1 - 0.0056 16.2 0.2 0.025 14.1 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 EFC49804.1 - 0.0063 16.9 0.1 0.064 13.6 0.1 2.2 1 1 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 EFC49804.1 - 0.0085 15.6 0.1 0.015 14.8 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 EFC49804.1 - 0.048 14.0 0.0 0.068 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Pox_A32 PF04665.12 EFC49804.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein TsaE PF02367.17 EFC49804.1 - 0.066 13.2 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 EFC49804.1 - 0.069 12.3 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 EFC49804.1 - 0.075 12.9 0.1 11 5.9 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 EFC49804.1 - 0.1 12.3 0.5 0.18 11.5 0.3 1.4 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 EFC49804.1 - 0.11 11.8 0.1 0.17 11.1 0.1 1.3 1 0 0 1 1 1 0 Septin AAA_33 PF13671.6 EFC49804.1 - 0.11 12.6 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain EGF_2 PF07974.13 EFC49805.1 - 2.3e-58 194.2 286.0 3e-05 24.3 4.0 18.5 18 0 0 18 18 18 18 EGF-like domain EGF PF00008.27 EFC49805.1 - 6.5e-14 51.9 211.2 0.0033 17.7 2.0 18.9 18 0 0 18 18 18 14 EGF-like domain C4bp_oligo PF18453.1 EFC49805.1 - 0.13 12.4 1.8 21 5.4 0.2 2.8 2 0 0 2 2 2 0 Oligomerization domain of C4b-binding protein alpha ABC2_membrane_3 PF12698.7 EFC49805.1 - 0.22 10.6 0.2 0.4 9.8 0.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein PPR PF01535.20 EFC49806.1 - 0.023 14.9 16.1 0.066 13.5 0.1 5.9 6 0 0 6 6 6 0 PPR repeat TrmE_N PF10396.9 EFC49806.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.2 1 1 0 1 1 1 0 GTP-binding protein TrmE N-terminus PPR_2 PF13041.6 EFC49806.1 - 0.47 10.7 0.1 0.47 10.7 0.1 4.2 4 1 1 5 5 5 0 PPR repeat family ATP13 PF12921.7 EFC49806.1 - 0.58 10.0 4.8 1.7 8.6 0.7 3.5 2 1 2 4 4 4 0 Mitochondrial ATPase expression HSCB_C PF07743.13 EFC49806.1 - 1.4 9.5 7.9 0.31 11.6 1.2 3.2 3 1 1 4 4 4 0 HSCB C-terminal oligomerisation domain Aha1_N PF09229.11 EFC49807.1 - 2.3e-30 105.6 1.8 4.9e-30 104.5 1.8 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 EFC49807.1 - 9e-21 74.4 0.0 1.8e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein SNARE PF05739.19 EFC49808.1 - 0.013 15.5 1.4 0.013 15.5 1.4 2.2 2 0 0 2 2 2 0 SNARE domain WXG100 PF06013.12 EFC49808.1 - 0.017 15.4 0.6 1.3 9.3 0.1 2.8 2 1 0 2 2 2 0 Proteins of 100 residues with WXG DUF1664 PF07889.12 EFC49808.1 - 0.018 15.1 4.0 0.018 15.1 4.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 EFC49808.1 - 0.038 13.8 14.8 0.026 14.4 3.9 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DASH_Duo1 PF08651.10 EFC49808.1 - 0.055 13.3 9.4 0.17 11.7 0.9 3.2 2 1 1 3 3 3 0 DASH complex subunit Duo1 Laminin_II PF06009.12 EFC49808.1 - 0.19 11.8 14.4 0.051 13.6 4.3 2.7 2 0 0 2 2 2 0 Laminin Domain II DUF745 PF05335.13 EFC49808.1 - 0.92 9.2 13.4 0.045 13.5 2.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DASH_Dam1 PF08653.10 EFC49808.1 - 2 8.2 4.1 46 3.9 0.1 3.6 2 1 1 3 3 3 0 DASH complex subunit Dam1 Orf78 PF06024.12 EFC49808.1 - 2.4 8.5 5.7 0.71 10.2 0.1 2.5 2 1 0 2 2 2 0 Orf78 (ac78) DUF4337 PF14235.6 EFC49808.1 - 4.3 7.4 7.8 0.17 12.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) TMPIT PF07851.13 EFC49808.1 - 4.8 6.3 12.9 0.2 10.8 0.7 2.2 2 0 0 2 2 2 0 TMPIT-like protein DUF948 PF06103.11 EFC49808.1 - 5.2 7.4 7.8 1.4 9.2 2.3 2.8 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF16 PF01519.16 EFC49808.1 - 8.1 7.0 18.8 0.32 11.5 2.4 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 Ribosomal_L35p PF01632.19 EFC49809.1 - 6.1e-18 65.1 14.2 1.1e-17 64.3 14.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L35 MORN PF02493.20 EFC49811.1 - 1.6e-39 131.5 59.9 4.2e-06 26.3 2.3 10.0 10 0 0 10 10 10 9 MORN repeat Vps54 PF07928.12 EFC49812.1 - 2.4e-29 102.5 1.0 2.4e-29 102.5 1.0 3.8 3 0 0 3 3 3 1 Vps54-like protein Vps54_N PF10475.9 EFC49812.1 - 2.6e-13 49.9 9.0 2.6e-13 49.9 9.0 2.7 2 1 1 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex DUF3734 PF12536.8 EFC49812.1 - 0.011 16.1 0.3 0.53 10.7 0.0 2.8 2 0 0 2 2 2 0 Patatin phospholipase AI-2E_transport PF01594.16 EFC49812.1 - 0.56 9.3 10.4 0.33 10.1 2.3 3.1 3 0 0 3 3 3 0 AI-2E family transporter PROCN PF08083.11 EFC49814.1 - 1.7e-233 774.7 9.8 3.1e-233 773.8 9.8 1.5 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 EFC49814.1 - 9.3e-122 405.0 0.9 9.3e-122 405.0 0.9 1.8 2 0 0 2 2 2 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 EFC49814.1 - 1.1e-86 288.7 3.6 2.9e-86 287.3 3.6 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.9 EFC49814.1 - 2.6e-73 244.4 0.1 5.4e-73 243.4 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 EFC49814.1 - 1e-47 161.0 0.2 3.4e-47 159.4 0.2 1.9 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 EFC49814.1 - 2.8e-44 149.4 0.3 7.4e-44 148.0 0.3 1.8 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 EFC49814.1 - 7.3e-08 32.4 0.0 2.3e-07 30.8 0.0 1.9 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PRO8NT PF08082.11 EFC49815.1 - 6.4e-78 259.9 1.0 1.2e-77 259.1 1.0 1.4 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain Sec3_C PF09763.9 EFC49815.1 - 0.25 9.7 0.9 0.33 9.3 0.9 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 zf-RING_2 PF13639.6 EFC49816.1 - 2.5e-09 37.3 12.2 2.5e-09 37.3 12.2 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 EFC49816.1 - 1.5e-06 28.3 5.8 3.5e-06 27.2 5.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 EFC49816.1 - 5.1e-06 26.1 7.0 5.1e-06 26.1 7.0 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 EFC49816.1 - 3.7e-05 23.5 12.3 3.7e-05 23.5 12.3 1.7 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC49816.1 - 0.0014 18.4 12.5 0.0014 18.4 12.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC49816.1 - 0.011 15.8 6.0 0.011 15.8 6.0 2.7 2 1 0 2 2 2 0 RING-type zinc-finger zf-RING_5 PF14634.6 EFC49816.1 - 0.015 15.3 12.2 0.015 15.3 12.2 1.8 2 0 0 2 2 1 0 zinc-RING finger domain zf-C3H2C3 PF17122.5 EFC49816.1 - 0.027 14.5 4.8 0.094 12.8 4.8 1.9 1 0 0 1 1 1 0 Zinc-finger DUF4064 PF13273.6 EFC49816.1 - 0.06 13.6 0.7 0.06 13.6 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) zf-ANAPC11 PF12861.7 EFC49816.1 - 0.24 11.5 4.4 0.51 10.4 4.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H PF13771.6 EFC49816.1 - 1.1 9.6 9.2 4 7.8 9.2 2.0 1 1 0 1 1 1 0 PHD-like zinc-binding domain zf-C3HC4_3 PF13920.6 EFC49816.1 - 1.8 8.5 20.2 0.028 14.3 11.2 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4834 PF16118.5 EFC49816.1 - 4.3 8.4 9.1 0.48 11.4 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Prok-RING_1 PF14446.6 EFC49816.1 - 6.5 6.8 14.2 0.83 9.6 7.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Calreticulin PF00262.18 EFC49817.1 - 7.4e-82 275.1 16.6 1.8e-60 204.7 5.6 2.4 1 1 1 2 2 2 2 Calreticulin family DnaJ PF00226.31 EFC49818.1 - 2.5e-20 72.3 1.5 3.6e-20 71.9 1.5 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 EFC49818.1 - 7.2e-06 25.6 0.9 2.1e-05 24.2 0.9 1.8 1 0 0 1 1 1 1 CSL zinc finger tRNA-synt_2d PF01409.20 EFC49819.1 - 1.3e-49 168.9 2.1 6.2e-49 166.7 2.1 1.9 1 1 0 1 1 1 1 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 EFC49819.1 - 4.2e-26 91.2 0.0 7.6e-24 84.0 0.0 2.6 2 0 0 2 2 2 2 Ferredoxin-fold anticodon binding domain TypeIII_RM_meth PF12564.8 EFC49819.1 - 0.23 11.6 1.4 0.61 10.3 0.2 2.3 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit Tox-ART-HYD1 PF15633.6 EFC49820.1 - 0.28 11.9 2.2 1.8 9.3 0.2 2.6 2 0 0 2 2 2 0 HYD1 signature containing ADP-ribosyltransferase EzrA PF06160.12 EFC49821.1 - 0.00018 19.9 15.8 0.00024 19.4 15.8 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF812 PF05667.11 EFC49821.1 - 0.009 14.9 13.9 0.014 14.3 13.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) LPP PF04728.13 EFC49821.1 - 0.086 13.2 0.6 0.086 13.2 0.6 2.5 3 1 0 3 3 2 0 Lipoprotein leucine-zipper FAM60A PF15396.6 EFC49821.1 - 0.63 10.0 8.5 1 9.3 8.5 1.3 1 0 0 1 1 1 0 Protein Family FAM60A FlaC_arch PF05377.11 EFC49821.1 - 0.85 10.1 6.4 7.3 7.1 2.9 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 EFC49821.1 - 2 8.8 16.5 3.3 8.1 16.0 1.6 1 1 1 2 2 2 0 Fez1 DUF1664 PF07889.12 EFC49821.1 - 4.6 7.3 11.0 33 4.5 8.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Enkurin PF13864.6 EFC49821.1 - 4.9 7.7 12.7 8.2 6.9 7.7 2.5 1 1 1 2 2 2 0 Calmodulin-binding CHD5 PF04420.14 EFC49821.1 - 5.5 6.8 8.2 11 5.8 8.2 1.6 1 0 0 1 1 1 0 CHD5-like protein DUF745 PF05335.13 EFC49821.1 - 6.3 6.5 17.6 3 7.5 1.4 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Spore_III_AB PF09548.10 EFC49821.1 - 6.9 6.7 7.5 4 7.5 4.2 2.0 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Spatacsin_C PF14649.6 EFC49821.1 - 9.8 5.2 11.4 88 2.1 11.4 1.9 1 1 0 1 1 1 0 Spatacsin C-terminus Ank_2 PF12796.7 EFC49824.1 - 9.2e-26 90.3 9.2 3.2e-07 30.8 2.5 5.4 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC49824.1 - 7.3e-25 87.0 7.0 7.1e-07 29.7 0.1 7.0 5 2 2 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC49824.1 - 4.5e-21 74.6 2.6 0.00014 22.0 0.0 5.9 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC49824.1 - 2.8e-16 59.1 12.1 6.6e-05 23.2 0.0 8.3 10 0 0 10 10 10 4 Ankyrin repeat Ank_3 PF13606.6 EFC49824.1 - 1.4e-15 55.8 7.9 0.047 14.2 0.0 8.6 9 0 0 9 9 9 5 Ankyrin repeat Myb_DNA-binding PF00249.31 EFC49825.1 - 4.1e-09 36.5 2.9 4.1e-09 36.5 2.9 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC49825.1 - 0.00059 19.7 0.9 0.00059 19.7 0.9 2.5 2 1 1 3 3 3 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 EFC49825.1 - 0.003 17.8 1.0 0.0098 16.1 1.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain CDC45 PF02724.14 EFC49825.1 - 0.77 8.0 9.9 0.87 7.8 9.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4652 PF15525.6 EFC49825.1 - 2.1 8.1 12.1 0.067 13.0 5.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4652) tRNA-synt_1e PF01406.19 EFC49827.1 - 1.8e-111 372.3 4.2 1.8e-111 372.3 4.2 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 EFC49827.1 - 0.0003 19.7 5.2 0.00052 18.9 0.7 3.0 3 1 1 4 4 4 1 tRNA synthetases class I (M) TPR_1 PF00515.28 EFC49828.1 - 0.062 13.1 0.2 39 4.3 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat SR-25 PF10500.9 EFC49828.1 - 0.58 9.7 37.5 0.047 13.3 11.7 2.9 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein GPS PF01825.21 EFC49829.1 - 0.0059 17.1 2.6 0.0059 17.1 2.6 3.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif EGF_2 PF07974.13 EFC49829.1 - 0.27 11.6 48.4 0.096 13.1 8.6 4.8 4 0 0 4 4 4 0 EGF-like domain EphA2_TM PF14575.6 EFC49829.1 - 3.6 8.5 4.9 5.5 7.9 0.5 3.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Adeno_E3 PF06040.11 EFC49829.1 - 4.8 7.4 8.1 37 4.5 8.1 2.6 1 0 0 1 1 1 0 Adenovirus E3 protein TPR_2 PF07719.17 EFC49830.1 - 0.00022 21.1 4.5 0.23 11.6 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC49830.1 - 0.00023 21.2 0.5 0.00023 21.2 0.5 3.0 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 EFC49830.1 - 0.00098 18.8 0.2 0.051 13.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49830.1 - 0.0012 19.4 0.3 0.13 13.0 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49830.1 - 0.0013 19.2 2.3 0.028 14.9 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat T3RM_EcoP15I_C PF18273.1 EFC49830.1 - 0.0044 17.3 0.2 0.027 14.8 0.2 2.5 1 1 0 1 1 1 1 Type III R-M EcoP15I C-terminal domain TPR_12 PF13424.6 EFC49830.1 - 0.015 15.6 4.8 2.5 8.4 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC49830.1 - 0.048 13.9 7.6 0.044 14.0 3.5 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 UIM PF02809.20 EFC49830.1 - 0.058 13.3 1.3 0.058 13.3 1.3 3.4 2 0 0 2 2 1 0 Ubiquitin interaction motif Comm PF15957.5 EFC49830.1 - 0.25 11.7 1.3 0.48 10.8 0.1 2.1 2 0 0 2 2 2 0 Commissureless TPR_10 PF13374.6 EFC49830.1 - 0.28 11.1 8.4 15 5.6 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat ABC2_membrane_3 PF12698.7 EFC49830.1 - 0.84 8.7 8.0 1.7 7.6 7.9 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein TPR_8 PF13181.6 EFC49830.1 - 2.3 8.6 0.0 2.3 8.6 0.0 4.4 4 2 1 5 5 4 0 Tetratricopeptide repeat Exo_endo_phos PF03372.23 EFC49831.1 - 0.05 13.1 0.0 0.19 11.2 0.0 2.0 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Peptidase_C1 PF00112.23 EFC49832.1 - 3.3e-57 194.1 2.2 3.3e-57 194.1 2.2 2.2 2 1 0 2 2 2 1 Papain family cysteine protease CathepsinC_exc PF08773.11 EFC49832.1 - 2.4e-19 69.8 1.3 6.8e-19 68.3 1.3 1.8 1 0 0 1 1 1 1 Cathepsin C exclusion domain Peptidase_C1_2 PF03051.15 EFC49832.1 - 2.8e-05 23.1 1.5 0.0012 17.7 0.2 2.2 2 0 0 2 2 2 2 Peptidase C1-like family Propeptide_C1 PF08127.13 EFC49832.1 - 0.00074 19.3 0.0 0.00074 19.3 0.0 1.9 2 0 0 2 2 2 1 Peptidase family C1 propeptide Polbeta PF18765.1 EFC49833.1 - 0.00023 21.2 0.1 0.0021 18.1 0.0 2.7 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase F-box-like PF12937.7 EFC49834.1 - 0.08 12.8 0.2 0.18 11.7 0.2 1.6 1 0 0 1 1 1 0 F-box-like Filamin PF00630.19 EFC49837.1 - 2.4e-68 227.4 16.6 6.2e-13 49.5 0.3 7.4 7 0 0 7 7 7 7 Filamin/ABP280 repeat Invasin_D3 PF09134.10 EFC49837.1 - 2.6e-17 62.9 0.1 0.018 15.3 0.0 6.5 7 0 0 7 7 7 4 Invasin, domain 3 C2 PF00168.30 EFC49837.1 - 8.8e-12 45.2 0.3 3.9e-11 43.1 0.2 2.2 2 0 0 2 2 2 1 C2 domain YtkA PF13115.6 EFC49837.1 - 2.5e-08 34.4 7.1 0.45 11.1 0.1 6.2 6 1 0 6 6 5 3 YtkA-like Y_Y_Y PF07495.13 EFC49837.1 - 2.2e-07 30.7 8.3 0.077 13.0 0.0 7.7 8 0 0 8 8 8 2 Y_Y_Y domain DUF5060 PF16586.5 EFC49837.1 - 1.2e-05 25.5 0.1 1.8 9.0 0.0 5.2 5 0 0 5 5 5 1 Domain of unknown function (DUF5060) PapC_N PF13954.6 EFC49837.1 - 0.00087 19.3 0.1 22 5.1 0.1 4.8 5 0 0 5 5 5 0 PapC N-terminal domain AdenylateSensor PF16579.5 EFC49837.1 - 0.002 18.5 0.1 1.1 9.8 0.2 2.6 2 0 0 2 2 2 1 Adenylate sensor of SNF1-like protein kinase FlgD_ig PF13860.6 EFC49837.1 - 0.0066 16.3 0.1 7.4 6.5 0.0 3.7 3 0 0 3 3 3 1 FlgD Ig-like domain He_PIG PF05345.12 EFC49837.1 - 0.023 14.9 5.0 3.6 7.9 0.0 5.4 6 0 0 6 6 6 0 Putative Ig domain DUF4198 PF10670.9 EFC49837.1 - 0.064 13.6 3.2 5.3 7.4 0.0 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF4198) BclA_C PF18573.1 EFC49837.1 - 0.075 13.0 0.3 69 3.4 0.0 4.2 4 0 0 4 4 4 0 BclA C-terminal domain Rieske PF00355.26 EFC49839.1 - 7.8e-18 64.2 0.2 1.6e-17 63.2 0.2 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 EFC49839.1 - 0.0012 18.8 0.0 0.0073 16.2 0.0 2.1 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain REJ PF02010.15 EFC49840.1 - 8.9e-23 80.8 24.5 1e-20 74.0 9.5 3.1 2 1 0 3 3 3 2 REJ domain Trypan_PARP PF05887.11 EFC49840.1 - 0.0034 17.4 91.3 1.8e+04 -37.9 91.3 3.2 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) EGF_2 PF07974.13 EFC49840.1 - 0.057 13.8 55.9 0.15 12.5 8.2 5.2 5 1 0 5 5 5 0 EGF-like domain I-EGF_1 PF18372.1 EFC49840.1 - 2.2 8.5 15.6 0.021 14.9 4.7 3.1 2 0 0 2 2 2 0 Integrin beta epidermal growth factor like domain 1 Tubulin PF00091.25 EFC49841.1 - 1.1e-53 182.4 0.1 2.1e-53 181.4 0.1 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 EFC49841.1 - 2.1e-27 95.8 0.0 3.9e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF2719 PF10891.8 EFC49841.1 - 0.0041 17.0 0.1 0.071 13.0 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2719) Tubulin_3 PF14881.6 EFC49841.1 - 0.037 13.7 0.0 0.073 12.7 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 EFC49841.1 - 0.09 11.9 0.2 0.19 10.9 0.1 1.5 1 1 0 1 1 1 0 Tubulin like DUF4834 PF16118.5 EFC49843.1 - 0.26 12.2 1.5 27 5.8 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RAMA PF18755.1 EFC49844.1 - 3.5e-13 49.9 0.4 3.3e-06 27.5 0.1 2.2 2 0 0 2 2 2 2 Restriction Enzyme Adenine Methylase Associated DUF3776 PF12618.8 EFC49844.1 - 0.013 16.1 13.4 0.22 12.1 4.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3776) DUF1882 PF08966.11 EFC49844.1 - 0.24 11.7 2.3 0.29 11.4 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1882) DUF3464 PF11947.8 EFC49844.1 - 6.3 6.5 7.4 2.9 7.6 1.6 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF4710 PF15828.5 EFC49844.1 - 9.3 6.5 10.4 1.4 9.1 3.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Pkinase PF00069.25 EFC49845.1 - 5.3e-71 239.1 0.5 6.1e-71 238.9 0.5 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49845.1 - 1.6e-44 152.1 0.0 2e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC49845.1 - 2.4e-09 36.9 0.0 4.1e-09 36.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 EFC49845.1 - 1.8e-06 27.0 0.0 2.4e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFC49845.1 - 2.7e-05 23.9 0.1 4.6e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 EFC49845.1 - 0.00018 20.6 2.0 0.00043 19.3 2.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC49845.1 - 0.00069 19.0 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC49845.1 - 0.0045 17.0 0.0 0.057 13.3 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family SNF2_N PF00176.23 EFC49845.1 - 0.027 13.2 0.3 0.04 12.6 0.3 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain ATP_bind_1 PF03029.17 EFC49846.1 - 4.9e-78 262.2 0.2 9.8e-78 261.3 0.0 1.5 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 EFC49846.1 - 6.1e-08 32.4 0.0 5.8e-07 29.2 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 EFC49846.1 - 1.6e-05 25.3 0.3 0.0073 16.7 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain Arf PF00025.21 EFC49846.1 - 3.3e-05 23.4 0.0 0.033 13.7 0.0 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family cobW PF02492.19 EFC49846.1 - 4.5e-05 23.1 0.2 0.00062 19.4 0.1 2.6 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 EFC49846.1 - 0.00013 21.6 0.2 0.019 14.6 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain FeoB_N PF02421.18 EFC49846.1 - 0.00024 20.7 0.0 0.0059 16.1 0.0 2.7 3 0 0 3 3 3 1 Ferrous iron transport protein B MeaB PF03308.16 EFC49846.1 - 0.00032 19.8 0.1 0.12 11.3 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 EFC49846.1 - 0.00036 20.6 0.0 0.033 14.3 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase NB-ARC PF00931.22 EFC49846.1 - 0.00095 18.4 0.0 0.0041 16.3 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_30 PF13604.6 EFC49846.1 - 0.0014 18.3 0.0 0.0024 17.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 EFC49846.1 - 0.0023 17.3 0.0 0.0045 16.3 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin DUF87 PF01935.17 EFC49846.1 - 0.0031 17.7 0.9 0.65 10.1 0.0 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain PduV-EutP PF10662.9 EFC49846.1 - 0.0043 16.8 0.1 0.14 11.9 0.0 3.0 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation Mei5 PF10376.9 EFC49846.1 - 0.0052 16.7 2.7 0.0067 16.3 2.7 1.2 1 0 0 1 1 1 1 Double-strand recombination repair protein RsgA_GTPase PF03193.16 EFC49846.1 - 0.0061 16.5 0.5 1.4 8.8 0.0 3.2 4 1 0 4 4 2 1 RsgA GTPase AAA_24 PF13479.6 EFC49846.1 - 0.0069 16.1 0.1 0.019 14.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EFC49846.1 - 0.011 14.9 0.7 0.32 10.1 0.0 2.5 2 1 1 3 3 3 0 G-protein alpha subunit NACHT PF05729.12 EFC49846.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 EFC49846.1 - 0.015 15.2 0.0 0.36 10.7 0.0 2.2 2 0 0 2 2 2 0 NTPase AAA_18 PF13238.6 EFC49846.1 - 0.02 15.5 1.0 0.53 10.8 0.0 3.1 3 1 0 3 3 3 0 AAA domain AAA_31 PF13614.6 EFC49846.1 - 0.022 14.7 0.0 2.5 8.0 0.0 2.5 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 EFC49846.1 - 0.029 14.6 0.0 4 7.7 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 EFC49846.1 - 0.035 14.4 0.1 0.18 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 EFC49846.1 - 0.07 12.6 1.6 6.1 6.2 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Torsin PF06309.11 EFC49846.1 - 0.071 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Torsin Peptidase_M9_N PF08453.10 EFC49846.1 - 0.071 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M9 N-terminal ABC_tran_Xtn PF12848.7 EFC49846.1 - 0.081 13.0 6.0 0.15 12.1 6.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 EFC49846.1 - 0.091 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CENP-Q PF13094.6 EFC49846.1 - 0.096 12.9 7.6 0.17 12.1 6.6 1.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Viral_helicase1 PF01443.18 EFC49846.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase APS_kinase PF01583.20 EFC49846.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.6 1 1 0 1 1 1 0 Adenylylsulphate kinase PhoH PF02562.16 EFC49846.1 - 0.13 11.7 0.0 6 6.3 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein MipZ PF09140.11 EFC49846.1 - 0.16 11.2 0.2 0.63 9.3 0.0 2.1 2 1 0 2 2 2 0 ATPase MipZ AAA_22 PF13401.6 EFC49846.1 - 0.17 12.2 0.1 0.67 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFC49846.1 - 0.17 11.2 0.0 0.41 9.9 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family TPR_14 PF13428.6 EFC49847.1 - 7.7e-12 45.0 0.0 17 6.6 0.0 9.4 10 1 1 11 11 11 2 Tetratricopeptide repeat NRDE-2 PF08424.10 EFC49847.1 - 4.3e-09 35.9 18.3 0.0018 17.4 0.3 4.6 2 1 1 4 4 4 3 NRDE-2, necessary for RNA interference TPR_8 PF13181.6 EFC49847.1 - 0.00011 22.2 10.6 5.2 7.5 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49847.1 - 0.0011 18.9 7.8 25 5.3 0.0 7.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49847.1 - 0.049 13.5 9.9 0.55 10.1 0.1 5.5 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49847.1 - 0.12 12.8 2.7 1.2e+02 3.4 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat UPF0262 PF06793.12 EFC49847.1 - 0.13 12.4 0.8 7.5 6.6 0.1 3.0 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0262) PPR PF01535.20 EFC49847.1 - 0.44 10.9 5.9 46 4.6 0.1 5.1 5 0 0 5 5 5 0 PPR repeat Sec3_C PF09763.9 EFC49848.1 - 4.2e-77 260.2 66.0 3.5e-74 250.5 66.0 2.2 1 1 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 EFC49848.1 - 1.2e-13 51.0 1.1 1.2e-13 51.0 1.1 2.6 2 0 0 2 2 2 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH IL2 PF00715.17 EFC49848.1 - 1 9.3 16.1 0.029 14.3 7.4 3.0 2 1 0 2 2 2 0 Interleukin 2 CNOT11 PF10155.9 EFC49848.1 - 4.2 7.5 16.7 5 7.3 1.9 4.4 3 1 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 CD34_antigen PF06365.12 EFC49849.1 - 0.0015 18.2 0.0 0.0025 17.4 0.0 1.3 1 0 0 1 1 1 1 CD34/Podocalyxin family LapA_dom PF06305.11 EFC49849.1 - 0.034 13.9 0.1 0.075 12.9 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Invasin_D3 PF09134.10 EFC49849.1 - 0.77 10.1 3.3 0.59 10.5 0.3 2.4 3 0 0 3 3 3 0 Invasin, domain 3 DUF5011 PF16403.5 EFC49849.1 - 2.6 8.2 4.6 4.7 7.4 0.3 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) Biotin_lipoyl PF00364.22 EFC49850.1 - 1e-16 60.5 0.0 4.5e-07 29.6 0.0 3.1 3 0 0 3 3 3 3 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 EFC49850.1 - 3.3e-07 30.0 0.1 0.0004 20.1 0.0 3.3 3 0 0 3 3 3 2 Biotin-lipoyl like PTS_EIIA_1 PF00358.20 EFC49850.1 - 0.02 14.6 0.0 0.24 11.2 0.0 2.7 3 1 1 4 4 4 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 GCV_H PF01597.19 EFC49850.1 - 0.093 12.6 0.0 5.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Glycine cleavage H-protein QRPTase_N PF02749.16 EFC49850.1 - 0.16 12.0 0.0 0.54 10.3 0.0 1.9 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, N-terminal domain NQRA PF05896.11 EFC49850.1 - 0.16 11.4 0.0 1.2 8.5 0.0 2.0 2 1 0 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DWNN PF08783.11 EFC49851.1 - 3.6e-28 97.7 0.4 6.8e-28 96.8 0.4 1.5 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 EFC49851.1 - 7e-10 38.5 15.1 1.2e-09 37.8 11.2 2.5 2 0 0 2 2 2 1 Zinc knuckle zf-RING_6 PF14835.6 EFC49851.1 - 0.00068 19.5 4.2 0.0013 18.5 4.2 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein U-box PF04564.15 EFC49851.1 - 0.00081 19.5 0.1 0.0021 18.2 0.1 1.7 1 0 0 1 1 1 1 U-box domain zf-C3HC4_3 PF13920.6 EFC49851.1 - 0.0016 18.3 12.1 0.0016 18.3 12.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC49851.1 - 0.0054 17.0 14.6 0.0054 17.0 14.6 1.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 EFC49851.1 - 0.022 14.6 15.1 0.022 14.6 15.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Lipocalin_7 PF14651.6 EFC49851.1 - 0.061 13.3 0.2 0.4 10.6 0.0 2.4 3 0 0 3 3 3 0 Lipocalin / cytosolic fatty-acid binding protein family zf-C3HC4_4 PF15227.6 EFC49851.1 - 0.065 13.4 13.5 0.13 12.4 13.5 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 EFC49851.1 - 0.097 12.6 17.6 0.23 11.3 17.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.19 EFC49851.1 - 0.14 12.2 11.9 26 4.9 8.0 3.2 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CCDC106 PF15794.5 EFC49851.1 - 0.38 10.4 10.5 0.68 9.6 0.2 2.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Pkinase PF00069.25 EFC49852.1 - 8.1e-50 169.6 7.5 5.1e-49 167.0 7.5 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC49852.1 - 1.7e-25 89.8 0.5 3.1e-25 88.9 0.5 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC49852.1 - 5.3e-08 32.5 0.3 2.7e-06 26.9 0.3 2.5 1 1 0 1 1 1 1 Kinase-like MH1 PF03165.16 EFC49852.1 - 0.0075 16.5 0.3 0.028 14.6 0.2 2.0 1 1 0 1 1 1 1 MH1 domain ZapC PF07126.12 EFC49852.1 - 0.085 12.4 0.8 1.2 8.7 0.1 2.5 1 1 1 2 2 2 0 Cell-division protein ZapC RIO1 PF01163.22 EFC49852.1 - 0.089 12.4 4.7 0.034 13.8 0.6 2.3 2 1 0 2 2 2 0 RIO1 family SpoVIF PF14069.6 EFC49853.1 - 0.15 11.9 1.5 0.2 11.4 0.1 2.0 2 0 0 2 2 2 0 Stage VI sporulation protein F AT_hook PF02178.19 EFC49854.1 - 3.6 7.8 8.0 10 6.3 8.0 1.8 1 0 0 1 1 1 0 AT hook motif DUF2992 PF11208.8 EFC49855.1 - 0.013 15.8 10.8 0.2 11.9 1.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2992) COX16 PF14138.6 EFC49855.1 - 0.52 10.9 2.3 0.59 10.7 0.4 1.9 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 BRCA-2_OB1 PF09103.10 EFC49856.1 - 4.1e-32 110.7 0.0 1.1e-31 109.4 0.0 1.8 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 EFC49856.1 - 9.4e-25 87.4 3.8 3.6e-23 82.2 0.2 3.7 4 1 0 4 4 4 2 BRCA2, helical BRCA-2_OB3 PF09104.10 EFC49856.1 - 0.00028 20.5 1.7 0.00028 20.5 1.7 2.4 2 1 0 2 2 2 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 PP2C_C PF07830.13 EFC49857.1 - 0.43 11.1 3.0 16 6.0 0.3 2.5 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain DUF4953 PF16313.5 EFC49857.1 - 0.45 9.7 3.6 0.3 10.2 1.4 1.7 1 1 1 2 2 2 0 Met-zincin ATP-synt_8 PF00895.20 EFC49857.1 - 2.1 8.9 8.7 1.3 9.5 0.2 3.1 2 0 0 2 2 2 0 ATP synthase protein 8 Herpes_gp2 PF05955.11 EFC49857.1 - 4.6 6.7 7.8 0.16 11.5 1.5 1.7 2 1 0 2 2 2 0 Equine herpesvirus glycoprotein gp2 Exo_endo_phos_2 PF14529.6 EFC49858.1 - 1.5e-05 24.8 0.8 1.5e-05 24.8 0.8 2.0 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase L27 PF02828.16 EFC49858.1 - 0.038 13.7 0.3 0.075 12.8 0.3 1.4 1 0 0 1 1 1 0 L27 domain HTH_40 PF14493.6 EFC49858.1 - 0.043 14.3 2.2 1 9.8 0.0 2.4 1 1 1 2 2 2 0 Helix-turn-helix domain K-box PF01486.17 EFC49858.1 - 0.077 13.2 2.1 0.13 12.5 0.1 2.2 1 1 1 2 2 2 0 K-box region RNase_H PF00075.24 EFC49859.1 - 6.9e-11 42.5 0.4 1.8e-10 41.2 0.4 1.7 1 1 0 1 1 1 1 RNase H PIGA PF08288.12 EFC49860.1 - 3e-38 130.3 0.1 7.4e-38 129.0 0.1 1.7 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 EFC49860.1 - 5.8e-28 98.0 0.4 1.2e-27 97.0 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 EFC49860.1 - 4.2e-27 94.8 0.0 7.1e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 EFC49860.1 - 1.9e-20 73.7 0.0 4e-20 72.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 EFC49860.1 - 3.9e-11 43.6 0.0 5.8e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 EFC49860.1 - 0.00012 22.4 0.0 0.00027 21.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 EFC49860.1 - 0.0014 18.7 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Zn_clus PF00172.18 EFC49861.1 - 3.2e-07 30.4 8.1 3.2e-07 30.4 8.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_peptidase PF04228.13 EFC49861.1 - 0.012 15.1 0.6 0.026 14.0 0.6 1.5 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase WBP-1 PF11669.8 EFC49862.1 - 5.7 7.6 9.7 1.7 9.3 1.9 3.2 2 1 1 3 3 3 0 WW domain-binding protein 1 DUF3484 PF11983.8 EFC49863.1 - 0.32 12.1 3.5 0.55 11.4 3.5 1.4 1 0 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch Acyltransferase PF01553.21 EFC49864.1 - 2.2e-22 79.1 0.0 3.9e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Lipoprotein_18 PF06804.11 EFC49864.1 - 0.092 11.8 0.1 0.15 11.1 0.1 1.3 1 0 0 1 1 1 0 NlpB/DapX lipoprotein PHD_4 PF16866.5 EFC49864.1 - 0.13 12.3 1.8 0.37 10.9 1.8 1.7 1 0 0 1 1 1 0 PHD-finger UDPG_MGDP_dh_N PF03721.14 EFC49865.1 - 1.8e-59 200.5 0.1 3.9e-59 199.4 0.1 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 EFC49865.1 - 7.6e-33 113.1 0.2 3.1e-32 111.1 0.1 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 EFC49865.1 - 1.9e-29 101.7 0.1 4e-29 100.7 0.1 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain 3HCDH_N PF02737.18 EFC49865.1 - 0.0036 17.2 0.0 0.0099 15.8 0.0 1.8 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 EFC49865.1 - 0.0071 16.5 0.0 0.12 12.5 0.0 2.6 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 EFC49865.1 - 0.041 14.2 0.0 0.17 12.1 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Aminotran_4 PF01063.19 EFC49866.1 - 3.2e-14 53.3 3.3 3.1e-12 46.8 3.3 2.9 1 1 0 1 1 1 1 Amino-transferase class IV DUF4388 PF14332.6 EFC49866.1 - 0.016 15.5 0.0 0.45 10.8 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4388) DUF2004 PF09406.10 EFC49866.1 - 7.8 6.9 9.4 2.3 8.6 0.3 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2004) AAA_5 PF07728.14 EFC49867.1 - 1.1e-06 28.7 0.0 2.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC49867.1 - 1.8e-05 25.0 0.0 4.6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 EFC49867.1 - 0.0018 18.1 0.0 0.0031 17.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 EFC49867.1 - 0.0057 17.1 0.2 0.018 15.5 0.2 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 EFC49867.1 - 0.0076 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 EFC49867.1 - 0.008 16.1 1.2 0.23 11.3 1.2 2.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 EFC49867.1 - 0.015 14.8 0.2 0.029 13.9 0.2 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 EFC49867.1 - 0.019 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC49867.1 - 0.022 15.1 0.0 0.045 14.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain PTPRCAP PF15713.5 EFC49870.1 - 1.6 9.0 12.0 3.4 8.0 12.0 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 EFC49870.1 - 1.9 6.6 15.9 2.1 6.5 15.9 1.1 1 0 0 1 1 1 0 Nop14-like family AA_kinase PF00696.28 EFC49871.1 - 7.4e-14 51.9 0.0 1.4e-13 51.0 0.0 1.4 1 1 0 1 1 1 1 Amino acid kinase family Sel1 PF08238.12 EFC49872.1 - 3.6e-98 319.8 39.7 1e-12 48.3 0.2 8.1 8 0 0 8 8 8 8 Sel1 repeat TPR_16 PF13432.6 EFC49872.1 - 1.1e-10 42.0 9.8 0.24 12.1 0.1 5.7 3 3 3 7 7 7 4 Tetratricopeptide repeat DUF512 PF04459.12 EFC49872.1 - 5.7e-06 25.7 13.1 0.28 10.4 0.1 5.0 1 1 4 5 5 5 5 Protein of unknown function (DUF512) Nucleos_tra2_N PF01773.20 EFC49872.1 - 3.6e-05 24.3 1.5 1.2e+02 3.3 0.0 7.2 6 2 2 8 8 8 0 Na+ dependent nucleoside transporter N-terminus TBSV_P22 PF03558.13 EFC49872.1 - 0.00012 21.6 7.8 9.1 5.7 0.0 6.2 1 1 7 8 8 8 1 TBSV core protein P21/P22 TPR_6 PF13174.6 EFC49872.1 - 0.00047 20.6 20.2 38 5.2 0.1 7.4 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF2442 PF10387.9 EFC49872.1 - 0.002 18.4 2.3 57 4.1 0.0 6.2 5 3 3 8 8 8 0 Protein of unknown function (DUF2442) TCP PF03634.13 EFC49872.1 - 0.0031 18.1 4.6 2.6e+02 2.1 0.0 6.8 8 0 0 8 8 8 0 TCP family transcription factor DUF2015 PF09435.10 EFC49872.1 - 0.13 12.1 8.8 36 4.3 0.1 5.1 2 2 1 4 4 4 0 Fungal protein of unknown function (DUF2015) ANAPC3 PF12895.7 EFC49872.1 - 0.76 10.0 14.5 1.2 9.4 0.5 5.0 1 1 4 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Ints3 PF10189.9 EFC49872.1 - 3.3 6.9 6.2 25 4.0 0.0 4.5 7 0 0 7 7 7 0 Integrator complex subunit 3 RCC1_2 PF13540.6 EFC49873.1 - 1.6e-10 40.5 5.4 0.044 13.6 0.1 4.7 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC49873.1 - 6.4e-06 26.7 0.0 0.93 10.2 0.0 5.3 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat TFA2_Winged_2 PF18121.1 EFC49874.1 - 5.3e-12 45.2 0.2 1.3e-11 44.0 0.2 1.7 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 HSP90 PF00183.18 EFC49875.1 - 1.6e-231 769.7 29.5 2e-231 769.4 29.5 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 EFC49875.1 - 4.6e-11 43.2 0.1 9.3e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 EFC49875.1 - 0.026 14.5 0.1 0.064 13.2 0.1 1.8 1 1 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Spore_III_AB PF09548.10 EFC49875.1 - 0.59 10.2 8.8 0.57 10.3 0.9 3.4 3 1 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) DUF601 PF04642.12 EFC49876.1 - 0.003 17.1 0.4 0.0079 15.7 0.4 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF601 DUF3800 PF12686.7 EFC49876.1 - 0.031 14.9 2.5 0.037 14.6 0.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) Ribonuc_L-PSP PF01042.21 EFC49876.1 - 2.1 8.4 7.1 0.3 11.1 1.2 2.4 2 0 0 2 2 2 0 Endoribonuclease L-PSP TRC8_N PF13705.6 EFC49876.1 - 4 6.3 6.0 1.4 7.8 0.4 2.1 1 1 1 2 2 2 0 TRC8 N-terminal domain TFIIE_alpha PF02002.17 EFC49877.1 - 4.7e-09 36.0 2.1 4.7e-09 36.0 2.1 1.8 2 0 0 2 2 2 1 TFIIE alpha subunit TFIIE-A_C PF11521.8 EFC49877.1 - 0.0018 18.6 13.7 0.041 14.2 13.7 2.8 1 1 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha TF_Zn_Ribbon PF08271.12 EFC49877.1 - 0.002 17.6 1.7 0.008 15.7 1.7 2.1 1 0 0 1 1 1 1 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 EFC49877.1 - 0.14 12.3 0.5 0.36 11.0 0.5 1.7 1 0 0 1 1 1 0 Zinc ribbon domain BCNT PF07572.12 EFC49879.1 - 2.4e-19 69.2 8.6 2.4e-19 69.2 8.6 2.0 2 0 0 2 2 2 1 Bucentaur or craniofacial development Vps53_N PF04100.12 EFC49881.1 - 2.6e-54 184.6 15.9 2.6e-54 184.6 15.9 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal RINT1_TIP1 PF04437.13 EFC49881.1 - 5e-05 22.4 16.2 5e-05 22.4 16.2 3.4 2 1 0 2 2 2 1 RINT-1 / TIP-1 family DUF2451 PF10474.9 EFC49881.1 - 7.3e-05 22.7 0.4 7.3e-05 22.7 0.4 2.4 3 1 0 3 3 3 1 Protein of unknown function C-terminus (DUF2451) HTH_WhiA PF02650.14 EFC49881.1 - 0.0045 17.3 0.4 0.0045 17.3 0.4 3.4 3 0 0 3 3 3 1 WhiA C-terminal HTH domain RCC1_2 PF13540.6 EFC49882.1 - 3.8e-08 32.9 0.3 3.8e-08 32.9 0.3 4.2 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC49882.1 - 1.6e-06 28.6 5.8 0.00029 21.4 0.2 4.5 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC49883.1 - 1.9e-14 53.0 4.7 0.00052 19.7 0.0 6.3 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC49883.1 - 2.8e-09 37.5 7.3 0.0034 18.0 0.0 5.7 6 0 0 6 6 6 3 Regulator of chromosome condensation (RCC1) repeat EGF_2 PF07974.13 EFC49883.1 - 1e-05 25.8 46.5 0.00077 19.8 9.5 3.8 3 0 0 3 3 3 2 EGF-like domain DUF4252 PF14060.6 EFC49884.1 - 0.062 13.2 0.0 0.23 11.4 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) Spc7 PF08317.11 EFC49885.1 - 0.051 12.5 0.0 0.061 12.2 0.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein PEX-1N PF09262.11 EFC49886.1 - 9.1e-18 64.5 0.0 1.9e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal PEX-2N PF09263.10 EFC49886.1 - 7.9e-05 22.9 0.0 0.002 18.4 0.0 2.4 2 0 0 2 2 2 1 Peroxisome biogenesis factor 1, N-terminal Fae PF08714.11 EFC49886.1 - 0.08 12.9 0.1 0.28 11.1 0.0 1.9 3 0 0 3 3 3 0 Formaldehyde-activating enzyme (Fae) AAA PF00004.29 EFC49887.1 - 1.5e-57 193.6 0.0 6.7e-42 143.0 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC49887.1 - 4.7e-11 42.3 0.0 1.6e-08 34.2 0.0 2.8 2 0 0 2 2 2 1 AAA+ lid domain IstB_IS21 PF01695.17 EFC49887.1 - 7.2e-09 35.6 0.0 0.0047 16.7 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 EFC49887.1 - 4e-08 33.9 0.3 0.018 15.6 0.0 3.6 3 1 0 3 3 3 2 AAA domain AAA_14 PF13173.6 EFC49887.1 - 1.8e-07 31.3 1.6 0.061 13.4 0.0 4.1 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 EFC49887.1 - 3.6e-07 30.7 0.7 0.01 16.2 0.0 3.8 2 2 2 4 4 3 1 AAA ATPase domain AAA_2 PF07724.14 EFC49887.1 - 7.3e-07 29.5 0.1 0.0043 17.2 0.0 3.4 4 0 0 4 4 3 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFC49887.1 - 2.3e-06 27.4 0.0 0.00059 19.6 0.0 3.3 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 EFC49887.1 - 3.6e-06 27.0 0.0 0.1 12.6 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 EFC49887.1 - 6.5e-06 26.5 0.0 0.1 13.0 0.0 3.8 3 0 0 3 3 3 1 RNA helicase AAA_22 PF13401.6 EFC49887.1 - 1.5e-05 25.3 1.0 0.57 10.5 0.0 4.2 3 2 2 5 5 3 2 AAA domain TIP49 PF06068.13 EFC49887.1 - 2.4e-05 23.7 0.0 0.0014 17.9 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 EFC49887.1 - 2.5e-05 24.4 0.2 0.0061 16.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 EFC49887.1 - 2.6e-05 24.2 0.2 0.036 14.1 0.0 4.2 4 1 0 4 4 3 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 EFC49887.1 - 0.00017 21.4 0.2 0.38 10.4 0.0 3.3 3 1 0 3 3 3 2 Sigma-54 interaction domain AAA_3 PF07726.11 EFC49887.1 - 0.00035 20.4 0.0 4.2 7.2 0.0 3.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 EFC49887.1 - 0.00045 20.4 0.1 1.2 9.3 0.0 3.3 3 0 0 3 3 2 1 Sigma-54 interaction domain NACHT PF05729.12 EFC49887.1 - 0.00062 19.7 0.3 6 6.8 0.0 4.2 3 1 0 3 3 3 0 NACHT domain AAA_7 PF12775.7 EFC49887.1 - 0.00068 19.2 0.0 1.1 8.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region Vps4_C PF09336.10 EFC49887.1 - 0.00071 19.5 0.1 0.0023 17.9 0.1 1.9 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_17 PF13207.6 EFC49887.1 - 0.00082 19.8 0.1 0.012 16.0 0.0 2.9 3 0 0 3 3 2 1 AAA domain T2SSE PF00437.20 EFC49887.1 - 0.001 18.2 1.4 3.1 6.8 0.1 3.4 2 1 1 3 3 3 2 Type II/IV secretion system protein Mg_chelatase PF01078.21 EFC49887.1 - 0.0014 18.0 0.0 0.094 12.1 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 EFC49887.1 - 0.0019 17.8 0.1 0.28 10.7 0.0 3.3 4 0 0 4 4 4 1 AAA domain Viral_helicase1 PF01443.18 EFC49887.1 - 0.0022 17.8 0.7 1 9.0 0.0 3.2 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase DUF3251 PF11622.8 EFC49887.1 - 0.0031 17.2 0.2 2.6 7.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3251) Zeta_toxin PF06414.12 EFC49887.1 - 0.004 16.5 0.0 0.3 10.3 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin Rad17 PF03215.15 EFC49887.1 - 0.0046 16.9 0.2 0.032 14.2 0.0 2.5 4 0 0 4 4 1 1 Rad17 P-loop domain AAA_24 PF13479.6 EFC49887.1 - 0.0046 16.7 1.7 0.92 9.2 0.0 3.2 4 0 0 4 4 3 1 AAA domain PhoH PF02562.16 EFC49887.1 - 0.0075 15.7 0.2 2 7.8 0.0 2.9 3 0 0 3 3 2 1 PhoH-like protein AAA_28 PF13521.6 EFC49887.1 - 0.01 16.1 0.0 4.1 7.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EFC49887.1 - 0.014 15.7 0.5 6.2 7.1 0.0 3.0 3 1 0 3 3 3 0 AAA domain AAA_30 PF13604.6 EFC49887.1 - 0.017 14.9 0.0 6.3 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 EFC49887.1 - 0.024 13.7 0.0 0.21 10.7 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 SAM_adeno_trans PF01887.16 EFC49887.1 - 0.028 13.9 0.1 0.058 12.8 0.1 1.5 1 0 0 1 1 1 0 S-adenosyl-l-methionine hydroxide adenosyltransferase AAA_29 PF13555.6 EFC49887.1 - 0.032 14.0 0.1 2 8.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 EFC49887.1 - 0.067 13.7 1.5 10 6.7 0.0 3.5 3 1 0 3 3 3 0 ABC transporter dNK PF01712.19 EFC49887.1 - 0.52 10.1 5.7 0.72 9.7 0.0 3.5 5 0 0 5 5 3 0 Deoxynucleoside kinase Hydin_ADK PF17213.3 EFC49887.1 - 2.7 8.2 8.7 8.9 6.5 0.0 3.3 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain CKS PF01111.19 EFC49888.1 - 2.3e-28 98.3 0.7 3.3e-28 97.7 0.7 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit TPR_1 PF00515.28 EFC49889.1 - 1.9e-26 90.7 21.5 8.7e-06 25.4 0.1 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49889.1 - 2.5e-18 64.6 14.9 0.017 15.2 0.2 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49889.1 - 1.4e-14 54.2 8.7 5.1e-06 26.7 0.1 5.2 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49889.1 - 5.2e-13 48.1 17.8 0.0047 17.0 0.7 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49889.1 - 4e-12 46.6 1.3 0.00064 20.3 0.4 5.3 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC49889.1 - 3.9e-09 35.9 0.5 0.18 11.9 0.0 5.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 EFC49889.1 - 1e-07 32.0 0.1 1.1 9.4 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC49889.1 - 1.8e-06 27.9 4.7 0.025 14.6 0.1 4.3 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 EFC49889.1 - 4.9e-06 26.8 4.0 0.044 14.4 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC49889.1 - 1e-05 25.2 7.8 0.12 12.2 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49889.1 - 0.00028 20.5 15.2 0.58 9.9 0.1 6.4 5 2 2 7 7 7 3 TPR repeat TPR_15 PF13429.6 EFC49889.1 - 0.00033 20.0 8.6 0.036 13.3 1.0 3.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC49889.1 - 0.0006 20.4 2.2 5.8 8.0 0.0 5.6 5 2 1 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49889.1 - 0.0013 19.0 15.0 0.0034 17.6 0.1 6.4 8 1 0 8 8 7 1 Tetratricopeptide repeat MIT PF04212.18 EFC49889.1 - 0.0089 16.1 5.1 5.1 7.2 0.0 5.0 4 1 1 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 EFC49889.1 - 0.05 14.1 8.0 7 7.3 0.0 4.3 3 1 1 4 4 4 0 Tetratricopeptide repeat BK_channel_a PF03493.18 EFC49889.1 - 0.054 13.7 0.3 0.17 12.1 0.3 1.8 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit EVI2A PF05399.11 EFC49889.1 - 5.7 6.5 11.8 17 4.9 7.6 2.3 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) RGS PF00615.19 EFC49890.1 - 3.3e-05 24.1 2.8 9.5e-05 22.6 2.8 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF5325 PF17259.2 EFC49890.1 - 9.9 6.1 7.2 11 6.0 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5325) Elongin_A PF06881.11 EFC49891.1 - 0.068 13.7 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A F-box PF00646.33 EFC49891.1 - 0.089 12.7 0.5 2.8 7.9 0.1 2.7 2 0 0 2 2 2 0 F-box domain Phage_HK97_TLTM PF06120.11 EFC49892.1 - 5.8 6.0 13.6 1.4 8.0 8.8 2.0 2 0 0 2 2 2 0 Tail length tape measure protein MORN PF02493.20 EFC49893.1 - 6.3e-41 135.9 58.6 1.5e-06 27.7 2.9 8.2 8 0 0 8 8 8 8 MORN repeat Tape_meas_lam_C PF09718.10 EFC49893.1 - 1.1 9.4 2.5 30 4.8 0.1 3.4 4 0 0 4 4 4 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) CPDase PF07823.11 EFC49896.1 - 0.013 15.2 0.1 0.018 14.8 0.1 1.2 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein PID_2 PF14719.6 EFC49896.1 - 0.11 12.4 0.5 0.17 11.8 0.5 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) LRR_4 PF12799.7 EFC49897.1 - 2.6e-17 62.6 56.7 1.3e-06 28.7 2.5 8.4 4 3 6 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC49897.1 - 3.5e-14 52.3 44.7 2.3e-07 30.5 9.8 7.1 5 3 2 8 8 8 6 Leucine rich repeat LRR_9 PF14580.6 EFC49897.1 - 2.5e-05 23.9 16.5 0.013 15.0 1.3 3.7 1 1 2 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 EFC49897.1 - 6.1e-05 22.8 39.2 0.93 9.7 0.5 9.9 11 0 0 11 11 11 5 Leucine Rich repeat LRR_1 PF00560.33 EFC49897.1 - 0.0039 17.5 37.9 6.9 7.6 0.0 11.3 11 1 0 11 11 11 2 Leucine Rich Repeat HU-CCDC81_bac_2 PF18175.1 EFC49897.1 - 0.015 15.1 0.6 0.18 11.7 0.1 2.5 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 SRP54 PF00448.22 EFC49898.1 - 5.9e-61 205.5 1.0 3.1e-43 147.7 0.1 2.1 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain AAA_22 PF13401.6 EFC49898.1 - 1.7e-07 31.6 0.1 3.5e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 EFC49898.1 - 3.5e-07 30.4 0.0 5.3e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 EFC49898.1 - 1.2e-05 24.7 0.1 3.7e-05 23.1 0.0 1.8 1 1 1 2 2 2 1 Zeta toxin MobB PF03205.14 EFC49898.1 - 0.00012 22.0 0.5 0.00024 21.0 0.5 1.6 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.6 EFC49898.1 - 0.00012 22.4 0.5 0.00025 21.4 0.5 1.5 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 EFC49898.1 - 0.00015 21.6 0.7 0.00031 20.7 0.7 1.5 1 1 0 1 1 1 1 Helicase AAA_30 PF13604.6 EFC49898.1 - 0.00022 21.0 1.3 0.00036 20.3 1.3 1.4 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 EFC49898.1 - 0.00028 20.8 2.4 0.0021 18.0 2.4 2.3 1 1 0 1 1 1 1 NTPase ABC_tran PF00005.27 EFC49898.1 - 0.00051 20.6 1.1 0.00057 20.4 0.1 1.6 2 0 0 2 2 1 1 ABC transporter TrwB_AAD_bind PF10412.9 EFC49898.1 - 0.00064 18.8 0.1 0.0014 17.6 0.0 1.6 1 1 1 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 EFC49898.1 - 0.0024 17.5 3.0 0.023 14.3 3.0 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 EFC49898.1 - 0.0061 16.0 0.3 0.023 14.1 0.1 2.0 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit DUF2075 PF09848.9 EFC49898.1 - 0.0099 15.1 0.1 0.015 14.6 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 EFC49898.1 - 0.012 15.0 0.2 0.023 14.0 0.2 1.6 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 EFC49898.1 - 0.012 16.0 0.1 0.022 15.1 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 EFC49898.1 - 0.017 15.3 0.9 0.034 14.3 0.8 1.6 1 1 0 1 1 1 0 AAA domain MeaB PF03308.16 EFC49898.1 - 0.024 13.6 0.1 0.044 12.8 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SNF2_N PF00176.23 EFC49898.1 - 0.038 12.7 0.2 0.045 12.5 0.2 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain KfrA_N PF11740.8 EFC49898.1 - 0.047 14.4 0.1 0.13 12.9 0.1 1.8 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term NACHT PF05729.12 EFC49898.1 - 0.049 13.5 1.1 1.7 8.5 0.2 2.7 2 2 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 EFC49898.1 - 0.05 14.0 0.5 0.64 10.4 0.3 2.8 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 EFC49898.1 - 0.081 12.6 1.2 0.19 11.4 0.2 1.9 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 EFC49898.1 - 0.083 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region SET PF00856.28 EFC49899.1 - 1e-08 35.8 0.3 5e-07 30.3 0.1 2.4 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 EFC49899.1 - 1.6e-08 35.3 0.6 5.3e-08 33.6 0.1 2.2 3 0 0 3 3 3 1 Rubisco LSMT substrate-binding DUF3445 PF11927.8 EFC49899.1 - 0.037 13.7 0.1 0.082 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) Bac_RepA_C PF18008.1 EFC49899.1 - 0.13 12.6 4.8 0.97 9.8 0.3 2.8 2 0 0 2 2 2 0 Replication initiator protein A C-terminal domain NOA36 PF06524.12 EFC49900.1 - 1.7 7.9 12.4 3 7.1 12.4 1.4 1 0 0 1 1 1 0 NOA36 protein Radial_spoke PF04712.12 EFC49900.1 - 3 6.7 11.2 5.2 5.9 4.0 2.1 2 0 0 2 2 2 0 Radial spokehead-like protein Yip1 PF04893.17 EFC49901.1 - 7.2e-10 38.8 24.2 4.8e-09 36.2 24.2 1.9 1 1 0 1 1 1 1 Yip1 domain EF-hand_5 PF13202.6 EFC49902.1 - 2.6e-10 39.3 2.5 7.9e-06 25.1 0.3 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 EFC49902.1 - 7.8e-10 37.9 2.2 0.00013 21.6 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 EFC49902.1 - 1e-09 37.2 3.2 0.00075 18.9 0.6 2.6 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 EFC49902.1 - 6.8e-09 36.1 4.9 2.1e-08 34.5 4.9 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 EFC49902.1 - 0.00031 20.5 0.6 0.062 13.2 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 EFC49902.1 - 0.0017 18.7 2.4 0.52 10.6 0.4 2.4 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Pox_RNA_Pol_19 PF05320.12 EFC49902.1 - 0.36 10.8 11.9 0.26 11.2 1.0 2.4 2 1 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit CtsR PF05848.11 EFC49903.1 - 0.00069 19.5 1.4 0.0023 17.8 0.0 2.6 3 0 0 3 3 3 1 CtsR N-terminal HTH domain TTRAP PF14203.6 EFC49903.1 - 0.15 12.1 2.1 1.8 8.6 0.1 3.5 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein BRCT PF00533.26 EFC49904.1 - 5.6e-47 158.0 13.8 1.1e-11 44.9 0.3 7.6 7 0 0 7 7 7 6 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC49904.1 - 2.4e-38 130.4 12.8 2.9e-10 40.4 0.0 7.8 7 0 0 7 7 7 7 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 EFC49904.1 - 1.5e-36 124.1 3.0 4.5e-18 64.9 0.1 6.1 7 0 0 7 7 7 3 twin BRCT domain RTT107_BRCT_5 PF16770.5 EFC49904.1 - 2.6e-13 49.7 11.9 3.9e-06 26.7 0.0 5.5 6 0 0 6 6 6 4 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EFC49904.1 - 2.1e-08 34.3 0.5 1.5 9.1 0.0 5.7 5 0 0 5 5 5 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 EFC49904.1 - 3.1e-07 30.4 0.0 1.3 9.1 0.0 5.0 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain PPR_2 PF13041.6 EFC49905.1 - 1e-89 294.6 33.4 1.9e-16 60.0 0.1 12.2 7 5 6 13 13 13 8 PPR repeat family PPR PF01535.20 EFC49905.1 - 6.2e-70 226.7 15.4 1.7e-06 27.8 0.0 16.8 18 0 0 18 18 17 12 PPR repeat PPR_3 PF13812.6 EFC49905.1 - 1.1e-48 163.1 18.7 6.8e-09 35.7 0.2 8.5 6 2 1 8 8 8 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC49905.1 - 7.6e-34 115.1 21.0 0.011 15.5 0.1 14.3 15 0 0 15 15 15 9 PPR repeat PPR_long PF17177.4 EFC49905.1 - 7.4e-27 94.1 1.7 8.1e-06 25.3 0.0 6.5 3 3 3 6 6 6 5 Pentacotripeptide-repeat region of PRORP MRP-S27 PF10037.9 EFC49905.1 - 2.6e-20 72.7 7.9 0.00014 20.9 0.3 4.8 4 0 0 4 4 4 4 Mitochondrial 28S ribosomal protein S27 ChAPs PF09295.10 EFC49905.1 - 1.7e-15 57.0 16.5 0.00062 18.9 1.2 5.8 4 2 1 5 5 5 5 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 EFC49905.1 - 2.2e-13 49.8 0.0 0.78 10.7 0.0 7.3 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49905.1 - 6.1e-13 48.0 0.0 1.7 8.6 0.0 6.8 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49905.1 - 1.3e-12 48.0 0.2 2 9.0 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat Acetyltransf_10 PF13673.7 EFC49905.1 - 6.5e-10 39.0 2.0 1.3 9.0 0.0 5.6 5 0 0 5 5 5 3 Acetyltransferase (GNAT) domain DUF3644 PF12358.8 EFC49905.1 - 7.5e-08 32.7 16.5 2.6 8.6 0.1 6.7 7 0 0 7 7 6 4 Protein of unknown function (DUF3644) LRR_2 PF07723.13 EFC49905.1 - 1.1e-06 29.0 3.5 23 5.9 0.0 5.7 5 0 0 5 5 5 0 Leucine Rich Repeat Acetyltransf_7 PF13508.7 EFC49905.1 - 1.9e-06 28.2 0.3 9 6.8 0.0 4.8 4 0 0 4 4 4 0 Acetyltransferase (GNAT) domain Tma16 PF11176.8 EFC49905.1 - 4.1e-06 26.7 1.7 4.1 7.3 0.0 5.9 3 2 2 6 6 6 1 Translation machinery-associated protein 16 HTH_7 PF02796.15 EFC49905.1 - 8.5e-06 25.7 1.5 60 3.8 0.0 5.8 5 0 0 5 5 5 0 Helix-turn-helix domain of resolvase P-II PF00543.22 EFC49905.1 - 8.6e-05 23.1 4.6 14 6.3 0.0 5.2 5 0 0 5 5 5 0 Nitrogen regulatory protein P-II HTH_Tnp_Tc3_1 PF11427.8 EFC49905.1 - 0.00012 21.8 6.3 56 3.7 0.0 6.2 6 0 0 6 6 5 0 Tc3 transposase DUF4322 PF14210.6 EFC49905.1 - 0.00059 19.7 4.6 48 3.9 0.0 6.4 6 0 0 6 6 6 0 Domain of unknown function (DUF4322) Katanin_con80 PF13925.6 EFC49905.1 - 0.00065 19.8 14.5 9.7 6.2 0.0 6.3 7 0 0 7 7 7 0 con80 domain of Katanin TPR_20 PF14561.6 EFC49905.1 - 0.00065 20.0 0.0 74 3.8 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TetR_C_5 PF08360.11 EFC49905.1 - 0.00069 19.8 18.2 0.61 10.3 0.4 4.6 4 0 0 4 4 4 3 QacR-like protein, C-terminal region VraX PF17412.2 EFC49905.1 - 0.00092 18.8 3.5 38 4.0 0.1 5.5 5 0 0 5 5 5 0 Family of unknown function TPR_2 PF07719.17 EFC49905.1 - 0.0017 18.3 5.3 1.7e+02 2.7 0.0 7.2 7 0 0 7 7 6 0 Tetratricopeptide repeat DUF5061 PF16587.5 EFC49905.1 - 0.0017 18.4 0.3 90 3.2 0.0 5.2 5 0 0 5 5 5 0 17 kDa common-antigen outer membrane protein Exonuc_VII_S PF02609.16 EFC49905.1 - 0.006 16.6 8.9 91 3.2 0.0 6.5 6 0 0 6 6 6 0 Exonuclease VII small subunit DUF4969 PF16339.5 EFC49905.1 - 0.009 16.3 6.0 1.3e+02 3.0 0.0 6.2 6 0 0 6 6 6 0 Domain of unknown function (DUF4969) TPR_6 PF13174.6 EFC49905.1 - 0.014 16.0 1.7 82 4.2 0.0 6.2 6 0 0 6 6 5 0 Tetratricopeptide repeat YscO PF07321.12 EFC49905.1 - 0.03 14.3 0.1 62 3.5 0.0 4.3 5 0 0 5 5 4 0 Type III secretion protein YscO OrfB_IS605 PF01385.19 EFC49905.1 - 0.057 13.6 0.1 24 5.2 0.0 3.5 3 0 0 3 3 3 0 Probable transposase PIEZO PF15917.5 EFC49905.1 - 0.058 12.9 11.8 5.9 6.3 0.1 4.6 5 0 0 5 5 5 0 Piezo TPR_17 PF13431.6 EFC49905.1 - 0.062 13.7 0.8 3.3e+02 2.0 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat gp45-slide_C PF09116.10 EFC49905.1 - 0.49 10.5 11.8 2.8 8.1 0.1 4.6 1 1 3 5 5 5 0 gp45 sliding clamp, C terminal TPR_11 PF13414.6 EFC49905.1 - 0.78 9.5 18.4 26 4.6 0.1 6.8 7 0 0 7 7 7 0 TPR repeat Lysozyme_like PF13702.6 EFC49905.1 - 1.1 9.0 7.9 44 3.7 0.1 4.8 5 0 0 5 5 5 0 Lysozyme-like HIT PF01230.23 EFC49905.1 - 1.8 9.3 5.4 45 4.9 0.0 4.7 5 1 0 5 5 4 0 HIT domain YyzF PF14116.6 EFC49905.1 - 2.6 8.2 4.3 93 3.2 0.1 4.0 4 0 0 4 4 4 0 YyzF-like protein PPR_2 PF13041.6 EFC49906.1 - 1.4e-90 297.3 46.3 4.9e-17 61.8 0.2 15.4 11 5 5 16 16 16 8 PPR repeat family PPR PF01535.20 EFC49906.1 - 1.9e-67 218.9 37.4 6.8e-07 29.1 0.0 18.7 20 0 0 20 20 18 11 PPR repeat PPR_3 PF13812.6 EFC49906.1 - 8.8e-40 134.6 31.6 2.4e-09 37.1 0.2 10.3 7 2 2 10 10 10 8 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC49906.1 - 1.7e-33 114.0 32.8 0.0027 17.4 0.1 15.3 16 0 0 16 16 16 9 PPR repeat DYW_deaminase PF14432.6 EFC49906.1 - 3.1e-28 98.2 2.4 9.1e-28 96.7 0.5 2.7 3 0 0 3 3 2 1 DYW family of nucleic acid deaminases PPR_long PF17177.4 EFC49906.1 - 3.5e-21 75.6 6.2 7.4e-07 28.8 0.2 5.4 1 1 4 5 5 5 5 Pentacotripeptide-repeat region of PRORP TPR_1 PF00515.28 EFC49906.1 - 1.1e-09 37.6 0.9 0.61 10.0 0.0 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49906.1 - 1.9e-09 37.9 0.4 11 6.6 0.0 6.6 6 1 1 7 7 6 0 Tetratricopeptide repeat ChAPs PF09295.10 EFC49906.1 - 2.1e-09 36.9 4.5 0.12 11.3 0.1 4.5 4 0 0 4 4 4 3 ChAPs (Chs5p-Arf1p-binding proteins) MRP-S27 PF10037.9 EFC49906.1 - 2.1e-09 36.8 3.1 0.076 11.9 0.1 4.5 3 1 0 4 4 4 3 Mitochondrial 28S ribosomal protein S27 TPR_14 PF13428.6 EFC49906.1 - 3.5e-08 33.6 0.0 31 5.8 0.0 7.3 5 1 2 7 7 6 0 Tetratricopeptide repeat Acetyltransf_10 PF13673.7 EFC49906.1 - 1.3e-07 31.5 2.3 1.9 8.5 0.0 4.9 5 0 0 5 5 5 2 Acetyltransferase (GNAT) domain TetR_C_5 PF08360.11 EFC49906.1 - 3.5e-05 24.0 21.0 0.43 10.8 0.5 5.7 6 0 0 6 6 5 3 QacR-like protein, C-terminal region HTH_7 PF02796.15 EFC49906.1 - 0.00031 20.7 0.6 71 3.6 0.0 4.9 4 0 0 4 4 4 0 Helix-turn-helix domain of resolvase Nucleocap_ssRNA PF11128.8 EFC49906.1 - 0.00032 20.5 2.2 17 5.0 0.0 5.1 5 0 0 5 5 5 0 Plant viral coat protein nucleocapsid YscO PF07321.12 EFC49906.1 - 0.0016 18.4 0.1 59 3.6 0.0 4.8 5 0 0 5 5 5 0 Type III secretion protein YscO End_beta_barrel PF12195.8 EFC49906.1 - 0.0017 18.3 0.0 71 3.5 0.1 4.5 4 0 0 4 4 4 0 Beta barrel domain of bacteriophage endosialidase Katanin_con80 PF13925.6 EFC49906.1 - 0.0024 17.9 2.5 6.1 6.9 0.1 3.5 3 0 0 3 3 3 0 con80 domain of Katanin HTH_Tnp_Tc3_1 PF11427.8 EFC49906.1 - 0.0043 16.9 6.1 60 3.6 0.0 5.6 5 0 0 5 5 5 0 Tc3 transposase OrfB_IS605 PF01385.19 EFC49906.1 - 0.0059 16.8 0.0 38 4.5 0.0 3.8 3 0 0 3 3 3 0 Probable transposase DUF3481 PF11980.8 EFC49906.1 - 0.006 16.3 0.1 2.5 7.9 0.0 3.5 3 0 0 3 3 3 1 C-terminal domain of neuropilin glycoprotein LRR_2 PF07723.13 EFC49906.1 - 0.0062 17.2 3.7 69 4.3 0.1 5.3 5 0 0 5 5 5 0 Leucine Rich Repeat Exonuc_VII_S PF02609.16 EFC49906.1 - 0.0095 16.0 3.0 1e+02 3.1 0.0 5.0 5 0 0 5 5 4 0 Exonuclease VII small subunit TPR_12 PF13424.6 EFC49906.1 - 0.017 15.4 0.0 11 6.4 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Sec63 PF02889.16 EFC49906.1 - 0.024 13.8 3.8 1.2 8.2 0.0 3.8 3 1 0 3 3 3 0 Sec63 Brl domain TPR_7 PF13176.6 EFC49906.1 - 0.025 14.6 2.7 1.2e+02 3.0 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat PYRIN PF02758.16 EFC49906.1 - 0.038 14.1 3.8 35 4.6 0.0 5.7 6 0 0 6 6 6 0 PAAD/DAPIN/Pyrin domain DUF5061 PF16587.5 EFC49906.1 - 0.043 13.9 0.3 1e+02 3.1 0.0 4.9 4 1 0 4 4 4 0 17 kDa common-antigen outer membrane protein TPK_B1_binding PF04265.14 EFC49906.1 - 0.12 12.1 0.8 21 4.9 0.0 4.0 4 0 0 4 4 4 0 Thiamin pyrophosphokinase, vitamin B1 binding domain TPR_6 PF13174.6 EFC49906.1 - 0.17 12.6 1.1 77 4.2 0.0 5.2 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49906.1 - 0.17 12.3 0.4 1.9e+02 2.8 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49906.1 - 0.33 11.2 8.0 2.2e+02 2.3 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49906.1 - 1.5 8.5 9.2 71 3.2 0.2 5.0 4 0 0 4 4 4 0 TPR repeat Lysozyme_like PF13702.6 EFC49906.1 - 4.1 7.1 9.2 84 2.8 0.0 4.7 5 0 0 5 5 5 0 Lysozyme-like TMEM144 PF07857.12 EFC49907.1 - 3.2e-77 259.7 10.8 6.6e-77 258.7 10.8 1.5 1 1 0 1 1 1 1 Transmembrane family, TMEM144 of transporters Sugar_transport PF06800.12 EFC49907.1 - 8.5e-10 38.4 16.2 7.5e-07 28.8 6.0 2.5 2 0 0 2 2 2 2 Sugar transport protein DUF2681 PF10883.8 EFC49907.1 - 0.0099 16.3 0.0 0.034 14.5 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) YbgT_YccB PF08173.11 EFC49907.1 - 0.092 12.9 1.2 0.48 10.6 1.2 2.3 1 0 0 1 1 1 0 Membrane bound YbgT-like protein DHHW PF14286.6 EFC49907.1 - 5.7 6.1 6.6 0.47 9.7 0.9 1.8 2 0 0 2 2 2 0 DHHW protein PNP_UDP_1 PF01048.20 EFC49908.1 - 8.6e-30 103.7 0.0 1e-29 103.5 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily RMP PF14996.6 EFC49909.1 - 1.1e-47 162.1 2.1 1.1e-47 162.1 2.1 2.0 2 0 0 2 2 2 1 Retinal Maintenance Acetyltransf_9 PF13527.7 EFC49911.1 - 0.0024 17.9 0.2 0.01 15.9 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF3929 PF13066.6 EFC49911.1 - 0.12 12.4 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3929) PI3_PI4_kinase PF00454.27 EFC49912.1 - 4.1e-52 177.5 0.1 4e-50 171.0 0.1 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 EFC49912.1 - 1.8e-47 161.2 0.7 2.7e-47 160.6 0.7 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 EFC49912.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) ABC_tran PF00005.27 EFC49913.1 - 2e-40 138.5 12.6 3e-20 73.2 0.0 3.5 3 1 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 EFC49913.1 - 9.2e-17 61.8 10.3 0.00016 21.6 0.1 4.7 3 2 2 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 EFC49913.1 - 7.8e-09 35.7 5.1 3.1e-06 27.2 0.8 3.1 1 1 1 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 EFC49913.1 - 2e-08 34.8 0.0 0.00058 20.3 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 EFC49913.1 - 2.9e-08 33.8 0.8 0.0077 16.2 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 EFC49913.1 - 1.6e-07 31.4 0.0 0.019 14.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_29 PF13555.6 EFC49913.1 - 2.7e-07 30.2 0.6 0.014 15.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 EFC49913.1 - 1.9e-06 28.2 1.6 0.021 15.1 0.1 3.3 2 2 0 2 2 2 2 AAA domain SMC_N PF02463.19 EFC49913.1 - 1.3e-05 24.7 11.4 0.037 13.5 0.2 4.5 3 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain NB-ARC PF00931.22 EFC49913.1 - 1.4e-05 24.5 0.5 0.14 11.3 0.4 2.8 2 1 0 2 2 2 2 NB-ARC domain AAA_5 PF07728.14 EFC49913.1 - 2e-05 24.6 2.5 0.39 10.7 0.0 4.2 5 0 0 5 5 4 2 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 EFC49913.1 - 2.4e-05 24.1 0.0 0.13 11.8 0.1 2.3 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_18 PF13238.6 EFC49913.1 - 2.5e-05 24.8 3.2 0.11 13.0 0.0 3.6 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 EFC49913.1 - 4.3e-05 23.3 1.2 0.019 14.7 0.0 2.6 3 0 0 3 3 2 1 AAA domain TsaE PF02367.17 EFC49913.1 - 6.8e-05 22.9 0.1 0.35 10.9 0.0 2.7 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 EFC49913.1 - 7.7e-05 23.1 0.3 0.96 9.9 0.0 3.6 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 EFC49913.1 - 8.6e-05 22.9 0.1 0.43 11.0 0.0 3.0 2 0 0 2 2 2 2 RNA helicase AAA_24 PF13479.6 EFC49913.1 - 0.00012 21.9 2.7 0.43 10.3 0.0 3.3 3 1 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 EFC49913.1 - 0.00013 21.4 0.0 1.3 8.4 0.1 3.4 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI DEAD PF00270.29 EFC49913.1 - 0.0002 21.1 0.0 0.07 12.9 0.5 3.0 2 2 0 2 2 2 1 DEAD/DEAH box helicase AAA_28 PF13521.6 EFC49913.1 - 0.0004 20.7 0.8 0.34 11.1 0.0 2.6 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 EFC49913.1 - 0.00043 19.8 0.2 0.43 10.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Roc PF08477.13 EFC49913.1 - 0.00044 20.5 2.8 0.34 11.1 0.0 3.2 3 0 0 3 3 2 2 Ras of Complex, Roc, domain of DAPkinase MobB PF03205.14 EFC49913.1 - 0.00047 20.1 0.4 0.2 11.5 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.9 EFC49913.1 - 0.00088 19.0 0.6 0.75 9.5 0.0 2.8 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 EFC49913.1 - 0.00095 19.3 0.0 0.96 9.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 EFC49913.1 - 0.00098 18.8 1.6 0.096 12.3 0.0 2.9 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 EFC49913.1 - 0.0014 17.7 0.5 0.011 14.8 0.1 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_13 PF13166.6 EFC49913.1 - 0.0016 17.2 11.3 0.17 10.5 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 EFC49913.1 - 0.002 18.7 0.4 0.002 18.7 0.4 4.6 1 1 2 3 3 1 1 AAA domain FeoB_N PF02421.18 EFC49913.1 - 0.002 17.7 0.1 1.7 8.1 0.1 2.9 3 0 0 3 3 2 1 Ferrous iron transport protein B DLIC PF05783.11 EFC49913.1 - 0.002 17.0 0.1 0.33 9.8 0.0 2.4 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) AAA_25 PF13481.6 EFC49913.1 - 0.0024 17.5 0.1 3.7 7.1 0.0 3.1 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 EFC49913.1 - 0.0043 17.1 0.3 2.9 8.0 0.0 3.0 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_14 PF13173.6 EFC49913.1 - 0.0046 17.0 8.3 0.13 12.3 0.0 4.1 4 2 0 4 4 4 1 AAA domain ABC_tran_Xtn PF12848.7 EFC49913.1 - 0.0048 16.9 6.0 0.01 15.8 6.0 1.5 1 0 0 1 1 1 1 ABC transporter Pox_A32 PF04665.12 EFC49913.1 - 0.0049 16.4 0.6 0.92 8.9 0.0 3.2 3 0 0 3 3 3 1 Poxvirus A32 protein KAP_NTPase PF07693.14 EFC49913.1 - 0.0063 15.8 0.0 0.87 8.8 0.0 2.4 2 1 0 2 2 2 1 KAP family P-loop domain AAA_11 PF13086.6 EFC49913.1 - 0.007 16.2 3.6 1.8 8.3 0.0 3.1 3 0 0 3 3 3 1 AAA domain Septin PF00735.18 EFC49913.1 - 0.0088 15.3 5.1 1 8.5 0.1 2.8 3 0 0 3 3 2 2 Septin SRP54 PF00448.22 EFC49913.1 - 0.01 15.5 0.7 3.4 7.2 0.0 2.7 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain DAP3 PF10236.9 EFC49913.1 - 0.01 15.1 0.3 0.93 8.6 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ATP_bind_1 PF03029.17 EFC49913.1 - 0.012 15.5 0.1 3.2 7.5 0.1 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Rad17 PF03215.15 EFC49913.1 - 0.016 15.2 1.1 11 5.9 0.0 3.2 3 0 0 3 3 3 0 Rad17 P-loop domain ATPase_2 PF01637.18 EFC49913.1 - 0.021 14.8 4.9 1.1 9.1 0.0 3.4 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 EFC49913.1 - 0.021 14.5 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain SRPRB PF09439.10 EFC49913.1 - 0.023 14.1 7.0 0.52 9.7 0.1 3.6 3 1 0 3 3 3 0 Signal recognition particle receptor beta subunit Sigma54_activ_2 PF14532.6 EFC49913.1 - 0.028 14.6 0.0 1.7 8.8 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain RuvB_N PF05496.12 EFC49913.1 - 0.029 14.1 0.0 2 8.1 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain dNK PF01712.19 EFC49913.1 - 0.048 13.5 3.3 2.4 8.0 0.1 3.0 3 0 0 3 3 3 0 Deoxynucleoside kinase Zeta_toxin PF06414.12 EFC49913.1 - 0.06 12.6 3.9 4.5 6.5 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin AAA_19 PF13245.6 EFC49913.1 - 0.063 13.6 0.1 7.3 6.9 0.1 2.7 2 1 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 EFC49913.1 - 0.1 11.9 0.1 5.6 6.2 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF3584 PF12128.8 EFC49913.1 - 0.11 10.0 12.1 0.7 7.3 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) NTPase_1 PF03266.15 EFC49913.1 - 0.21 11.5 6.5 3.3 7.6 0.1 3.6 4 0 0 4 4 3 0 NTPase Thymidylate_kin PF02223.17 EFC49913.1 - 1.2 8.8 6.5 4 7.1 0.0 3.1 3 0 0 3 3 2 0 Thymidylate kinase AAA_27 PF13514.6 EFC49913.1 - 1.3 8.5 5.7 8.9 5.8 0.0 3.0 3 1 0 3 3 2 0 AAA domain bacHORMA_2 PF18173.1 EFC49915.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial HORMA domain 2 RecG_N PF17190.4 EFC49915.1 - 0.22 12.3 3.7 0.8 10.5 0.7 2.6 2 1 0 2 2 2 0 RecG N-terminal helical domain GvpK PF05121.12 EFC49916.1 - 0.3 11.2 9.5 5.3 7.1 0.4 3.6 3 0 0 3 3 3 0 Gas vesicle protein K Histone_HNS PF00816.21 EFC49916.1 - 1.8 9.4 5.2 0.54 11.1 0.3 2.7 2 1 1 3 3 3 0 H-NS histone family adh_short PF00106.25 EFC49918.1 - 1.2e-36 126.1 0.0 1.6e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC49918.1 - 4.8e-19 68.8 0.0 7.2e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC49918.1 - 8.1e-11 42.1 0.1 1.7e-10 41.1 0.1 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 EFC49918.1 - 1.9e-05 24.0 0.6 2.9e-05 23.4 0.6 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 EFC49918.1 - 0.025 14.3 0.1 0.073 12.8 0.1 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF4347 PF14252.6 EFC49918.1 - 0.053 13.4 0.0 0.55 10.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4347) NAD_binding_6 PF08030.12 EFC49918.1 - 0.1 12.7 0.1 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Ferric reductase NAD binding domain GDP_Man_Dehyd PF16363.5 EFC49918.1 - 0.18 11.2 0.1 0.29 10.5 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF2852 PF11014.8 EFC49919.1 - 0.067 13.3 0.5 7.7 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) RII_binding_1 PF10522.9 EFC49919.1 - 1.1 9.6 0.0 1.1 9.6 0.0 2.7 3 0 0 3 3 3 0 RII binding domain HA2 PF04408.23 EFC49921.1 - 4.4e-05 23.7 0.0 4.4e-05 23.7 0.0 3.2 3 1 0 3 3 3 1 Helicase associated domain (HA2) DEAD PF00270.29 EFC49921.1 - 0.04 13.7 0.1 0.15 11.9 0.1 2.0 1 0 0 1 1 1 0 DEAD/DEAH box helicase DUF1840 PF08895.11 EFC49921.1 - 0.62 10.4 3.6 1 9.7 0.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) TTC5_OB PF16669.5 EFC49922.1 - 0.077 12.7 0.1 2.1 8.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat protein 5 OB fold domain TAP42 PF04177.12 EFC49923.1 - 6.8e-34 117.4 13.6 9.1e-34 117.0 13.6 1.1 1 0 0 1 1 1 1 TAP42-like family CutA1 PF03091.15 EFC49923.1 - 0.12 12.2 0.1 9.1 6.2 0.0 2.5 2 0 0 2 2 2 0 CutA1 divalent ion tolerance protein RNA_pol_L_2 PF13656.6 EFC49925.1 - 9.4e-25 86.2 0.1 1.5e-24 85.5 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 EFC49925.1 - 1.8e-06 27.3 0.0 3.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Glyco_tran_28_C PF04101.16 EFC49926.1 - 1.9e-24 86.5 0.0 2.1e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain His_Phos_2 PF00328.22 EFC49927.1 - 4.8e-21 75.5 0.0 3.8e-20 72.6 0.0 2.2 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Glycophorin_A PF01102.18 EFC49927.1 - 0.041 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Glycophorin A DUF3377 PF11857.8 EFC49927.1 - 0.05 13.5 0.6 0.099 12.6 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMEM154 PF15102.6 EFC49927.1 - 0.052 13.4 0.3 0.15 12.0 0.1 1.9 2 0 0 2 2 2 0 TMEM154 protein family VPS13_C PF16909.5 EFC49928.1 - 2.5e-61 206.6 0.7 2.5e-61 206.6 0.7 5.0 5 1 1 6 6 6 3 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 EFC49928.1 - 2.2e-59 201.1 7.3 2.2e-59 201.1 7.3 4.0 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 EFC49928.1 - 8.5e-40 136.6 9.1 2.7e-38 131.7 7.5 5.9 5 3 2 7 7 7 2 Repeating coiled region of VPS13 Chorein_N PF12624.7 EFC49928.1 - 2.5e-34 117.9 0.1 2.5e-34 117.9 0.1 4.2 4 0 0 4 4 4 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 EFC49928.1 - 5.9e-12 45.8 0.1 2.7e-11 43.7 0.1 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain PH PF00169.29 EFC49928.1 - 0.00042 20.8 2.3 0.0014 19.1 0.0 3.3 4 0 0 4 4 4 1 PH domain SHR-BD PF06650.12 EFC49928.1 - 0.0052 16.2 8.9 0.073 12.4 0.0 4.8 4 1 0 4 4 4 1 SHR-binding domain of vacuolar-sorting associated protein 13 ThiC_Rad_SAM PF01964.18 EFC49928.1 - 0.034 13.0 0.8 0.11 11.3 0.5 2.0 2 0 0 2 2 2 0 Radical SAM ThiC family zf-MYND PF01753.18 EFC49929.1 - 4.7e-10 39.4 16.1 9.5e-10 38.4 16.1 1.6 1 0 0 1 1 1 1 MYND finger Macoilin PF09726.9 EFC49929.1 - 0.014 14.0 11.4 0.018 13.6 11.4 1.2 1 0 0 1 1 1 0 Macoilin family DUF2621 PF11084.8 EFC49929.1 - 0.03 14.3 0.0 0.076 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) Ureide_permease PF07168.11 EFC49929.1 - 0.037 12.8 1.7 0.077 11.7 1.7 1.5 1 0 0 1 1 1 0 Ureide permease DUF1010 PF06231.11 EFC49929.1 - 0.24 12.0 2.1 0.65 10.5 2.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1010) Rhodanese_C PF12368.8 EFC49929.1 - 0.9 10.0 10.3 2.3 8.6 10.3 1.7 1 0 0 1 1 1 0 Rhodanase C-terminal DUF2256 PF10013.9 EFC49929.1 - 0.98 9.6 6.7 2 8.6 6.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Mss51 PF13824.6 EFC49929.1 - 2.3 8.4 7.1 5.8 7.1 7.1 1.6 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DHO_dh PF01180.21 EFC49930.1 - 1.3e-89 300.3 0.1 1.6e-89 300.1 0.1 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 EFC49930.1 - 0.0026 16.8 0.9 0.032 13.2 0.9 2.4 2 1 0 2 2 2 1 FMN-dependent dehydrogenase NMO PF03060.15 EFC49930.1 - 0.0038 16.7 0.3 0.0074 15.7 0.2 1.4 2 0 0 2 2 2 1 Nitronate monooxygenase PI-PLC-X PF00388.19 EFC49930.1 - 0.04 13.5 0.0 0.061 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain ABC1 PF03109.16 EFC49930.1 - 0.095 12.9 0.4 0.25 11.5 0.1 1.7 2 0 0 2 2 2 0 ABC1 family DUF1694 PF07997.11 EFC49930.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) LIN52 PF10044.9 EFC49931.1 - 0.093 13.4 0.7 4.4 8.1 0.2 3.2 2 0 0 2 2 2 0 Retinal tissue protein Zn_clus PF00172.18 EFC49932.1 - 9.2e-08 32.1 11.9 1.9e-07 31.1 11.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TLE_N PF03920.15 EFC49932.1 - 0.021 14.9 0.4 0.053 13.6 0.4 1.6 1 0 0 1 1 1 0 Groucho/TLE N-terminal Q-rich domain ORC5_C PF14630.6 EFC49933.1 - 9.9e-12 45.0 1.0 2.1e-11 43.9 1.0 1.5 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus DARPP-32 PF05395.12 EFC49933.1 - 8.2 6.6 16.9 0.49 10.6 11.5 1.7 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 RGCC PF15151.6 EFC49936.1 - 1 9.6 6.0 0.79 10.0 2.0 2.7 3 1 0 3 3 3 0 Response gene to complement 32 protein family Peptidase_C1 PF00112.23 EFC49937.1 - 5.4e-61 206.5 6.3 6e-61 206.3 6.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 EFC49937.1 - 0.0077 15.1 0.5 0.0077 15.1 0.5 2.2 2 0 0 2 2 2 1 Peptidase C1-like family REJ PF02010.15 EFC49938.1 - 1.5e-38 132.8 15.1 7.1e-35 120.7 7.5 2.8 1 1 1 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC49938.1 - 1.2e-17 64.0 201.5 0.0011 19.3 9.2 14.5 11 3 2 13 13 13 10 EGF-like domain Y_Y_Y PF07495.13 EFC49938.1 - 0.11 12.5 0.1 14 5.7 0.0 3.2 3 0 0 3 3 3 0 Y_Y_Y domain REJ PF02010.15 EFC49939.1 - 8.2e-46 156.7 10.1 5.4e-38 130.9 6.3 2.5 1 1 0 2 2 2 2 REJ domain EGF_2 PF07974.13 EFC49939.1 - 1.1e-09 38.5 118.3 0.0055 17.0 6.6 10.3 9 1 1 10 10 10 5 EGF-like domain DUF3494 PF11999.8 EFC49939.1 - 0.00028 20.6 2.1 0.00046 19.9 1.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3494) Laminin_EGF PF00053.24 EFC49939.1 - 0.0018 18.4 102.2 0.53 10.5 14.9 6.8 4 3 2 6 6 6 4 Laminin EGF domain DSL PF01414.19 EFC49939.1 - 0.0045 17.2 14.5 0.0045 17.2 14.5 6.2 4 1 0 5 5 5 1 Delta serrate ligand PDEase_I PF00233.19 EFC49940.1 - 1.4e-69 234.4 3.4 2.3e-69 233.7 3.4 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 EFC49940.1 - 0.04 14.1 0.1 0.091 13.0 0.1 1.7 1 0 0 1 1 1 0 HD domain MRP_L53 PF10780.9 EFC49941.1 - 3.3e-05 24.0 0.0 5.4e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 GDWWSH PF15667.5 EFC49942.1 - 0.022 14.2 1.1 0.82 9.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function with motif GDWWSH Antistasin PF02822.14 EFC49943.1 - 5.6e-43 145.2 104.0 3.5e-07 30.7 10.5 6.2 6 0 0 6 6 6 6 Antistasin family DNA_RNApol_7kD PF03604.13 EFC49944.1 - 2.9e-15 55.6 6.3 4.5e-15 55.0 6.3 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit RNHCP PF12647.7 EFC49944.1 - 0.0076 16.2 4.8 1.2 9.2 1.2 2.2 1 1 1 2 2 2 2 RNHCP domain DUF2318 PF10080.9 EFC49944.1 - 0.015 15.4 3.5 0.021 14.9 3.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Msap1 PF17077.5 EFC49944.1 - 0.019 14.1 0.1 0.02 14.1 0.1 1.2 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 zinc_ribbon_13 PF09855.9 EFC49944.1 - 0.033 14.3 0.9 0.033 14.3 0.9 1.5 1 1 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Zn_ribbon_recom PF13408.6 EFC49944.1 - 0.84 10.2 9.1 1.8 9.2 6.4 2.3 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Tnp_zf-ribbon_2 PF13842.6 EFC49944.1 - 2.1 9.2 9.5 2.4 9.0 6.2 2.1 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Syja_N PF02383.18 EFC49945.1 - 2e-48 165.4 0.1 3.8e-48 164.4 0.1 1.5 1 0 0 1 1 1 1 SacI homology domain FYVE PF01363.21 EFC49945.1 - 0.00017 21.7 16.1 0.00047 20.3 16.1 1.8 1 0 0 1 1 1 1 FYVE zinc finger Sad1_UNC PF07738.13 EFC49945.1 - 0.024 14.6 0.2 0.15 12.1 0.2 2.5 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal zf-4CXXC_R1 PF10497.9 EFC49945.1 - 1.2 9.5 12.2 2.4 8.4 11.2 2.1 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C3HC4_2 PF13923.6 EFC49945.1 - 5.8 6.8 11.1 17 5.4 11.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC49945.1 - 7.4 6.7 9.4 27 4.9 9.4 2.0 1 0 0 1 1 1 0 RING-type zinc-finger LAMTOR PF15454.6 EFC49946.1 - 0.065 13.9 0.7 0.28 11.8 0.0 2.3 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DENN PF02141.21 EFC49947.1 - 2e-45 155.1 1.8 4.3e-45 153.9 1.8 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 EFC49947.1 - 2e-12 47.6 0.1 2e-12 47.6 0.1 2.4 2 0 0 2 2 2 1 uDENN domain dDENN PF03455.19 EFC49947.1 - 0.098 12.7 1.3 0.29 11.2 1.3 1.9 1 0 0 1 1 1 0 dDENN domain F5_F8_type_C PF00754.25 EFC49948.1 - 1.5e-10 41.3 0.1 0.0019 18.3 0.0 3.3 3 0 0 3 3 3 3 F5/8 type C domain Guanylate_cyc PF00211.20 EFC49950.1 - 1.2e-40 139.1 0.9 2.3e-40 138.2 0.9 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC49950.1 - 5.9e-17 61.7 0.5 1.3e-09 38.1 0.0 3.6 4 0 0 4 4 4 2 PAS fold PAS_9 PF13426.7 EFC49950.1 - 1.1e-12 48.1 0.5 1.6e-08 34.7 0.2 2.8 2 0 0 2 2 2 2 PAS domain PAS_4 PF08448.10 EFC49950.1 - 9.3e-07 29.1 0.0 0.014 15.7 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 EFC49950.1 - 0.0003 20.7 0.0 0.55 10.3 0.0 2.8 2 0 0 2 2 2 2 PAS domain DUF5625 PF18539.1 EFC49950.1 - 0.01 16.2 0.7 0.032 14.5 0.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5625) PAS_10 PF13596.6 EFC49950.1 - 0.028 15.0 0.2 1.4 9.5 0.2 3.0 2 1 0 2 2 2 0 PAS domain BPL_LplA_LipB PF03099.19 EFC49951.1 - 6.5e-07 29.3 0.0 1.2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 EFC49951.1 - 0.055 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Thiolase_N PF00108.23 EFC49952.1 - 1.3e-83 280.4 1.2 1.7e-83 280.0 0.2 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 EFC49952.1 - 3e-43 146.4 0.2 6.7e-43 145.3 0.2 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 EFC49952.1 - 0.0027 17.3 0.1 0.014 15.0 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain DUF5595 PF18077.1 EFC49952.1 - 0.1 12.7 0.2 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) Dodecin PF07311.12 EFC49952.1 - 0.19 12.0 2.1 0.52 10.6 0.2 2.6 3 0 0 3 3 3 0 Dodecin DUF1635 PF07795.11 EFC49953.1 - 0.0083 16.0 1.3 0.0097 15.8 0.6 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1635) ssDNA_DBD PF18333.1 EFC49954.1 - 0.019 15.1 0.4 0.081 13.0 0.1 2.1 2 0 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain G_glu_transpept PF01019.21 EFC49955.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase Cation_ATPase_C PF00689.21 EFC49956.1 - 5.1e-39 133.9 7.5 5.1e-39 133.9 7.5 3.5 4 1 0 4 4 4 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 EFC49956.1 - 3e-36 124.6 0.3 3e-36 124.6 0.3 2.8 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 EFC49956.1 - 4.1e-19 69.7 0.0 3.9e-18 66.5 0.0 2.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC49956.1 - 3e-14 52.9 1.0 4.8e-14 52.2 0.1 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC49956.1 - 7.8e-10 38.3 0.0 3.7e-09 36.1 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC49956.1 - 1.3e-05 25.0 1.2 0.00098 18.9 0.2 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase ATPase_gene1 PF09527.10 EFC49956.1 - 0.016 15.4 1.0 0.016 15.4 1.0 2.6 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Ni_hydr_CYTB PF01292.20 EFC49956.1 - 0.13 11.9 4.2 4.1 7.0 0.0 3.2 3 1 0 3 3 3 0 Prokaryotic cytochrome b561 Spore_GerAC PF05504.11 EFC49956.1 - 1.9 8.7 4.8 6 7.1 0.0 2.9 2 1 1 3 3 3 0 Spore germination B3/ GerAC like, C-terminal UQ_con PF00179.26 EFC49957.1 - 2.7e-20 72.5 0.0 5.4e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Spuma_A9PTase PF03539.14 EFC49957.1 - 0.01 16.0 0.0 0.015 15.4 0.0 1.2 1 0 0 1 1 1 0 Spumavirus aspartic protease (A9) RWD PF05773.22 EFC49957.1 - 0.039 14.2 0.8 0.059 13.7 0.0 1.8 2 0 0 2 2 2 0 RWD domain Glyco_transf_10 PF00852.19 EFC49958.1 - 7.9e-26 90.8 0.0 1.6e-25 89.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term M16C_assoc PF08367.11 EFC49959.1 - 3.4e-08 32.9 0.0 7.8e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16C associated KHA PF11834.8 EFC49959.1 - 0.095 12.8 0.0 0.26 11.4 0.0 1.7 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel GluR_Homer-bdg PF10606.9 EFC49959.1 - 2.8 8.2 5.4 0.86 9.9 1.1 2.5 2 0 0 2 2 2 0 Homer-binding domain of metabotropic glutamate receptor FAP206 PF12018.8 EFC49960.1 - 4.3e-11 42.8 26.9 5.9e-08 32.5 0.0 6.6 6 1 1 7 7 7 4 Domain of unknown function ADK PF00406.22 EFC49960.1 - 1.7e-08 34.7 7.9 6.8e-08 32.8 0.4 3.4 3 0 0 3 3 3 1 Adenylate kinase YHS PF04945.13 EFC49960.1 - 9.3e-07 28.8 2.2 0.012 15.7 0.0 4.8 5 0 0 5 5 5 2 YHS domain SF3A2 PF16835.5 EFC49961.1 - 3.9e-33 113.7 0.5 7.2e-33 112.8 0.5 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) CactinC_cactus PF09732.9 EFC49961.1 - 5.7e-06 26.3 2.6 1.7e-05 24.7 2.6 1.8 1 1 0 1 1 1 1 Cactus-binding C-terminus of cactin protein zf-met PF12874.7 EFC49961.1 - 2.1e-05 24.7 1.0 4e-05 23.9 1.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PPR PF01535.20 EFC49962.1 - 8.3e-14 50.8 15.4 0.0093 16.2 0.3 7.3 7 0 0 7 7 7 5 PPR repeat PPR_2 PF13041.6 EFC49962.1 - 2e-07 31.1 15.7 0.044 14.0 0.2 6.4 6 1 1 7 7 7 3 PPR repeat family Death PF00531.22 EFC49962.1 - 0.016 15.3 1.4 0.26 11.5 0.1 2.9 2 1 0 2 2 2 0 Death domain TPR_1 PF00515.28 EFC49962.1 - 0.54 10.2 5.1 1.2 9.1 0.6 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Histone PF00125.24 EFC49963.1 - 2e-35 122.0 4.8 2e-35 122.0 4.8 2.1 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 EFC49963.1 - 5.6e-06 26.4 0.2 9.6e-06 25.7 0.2 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 EFC49963.1 - 0.0053 17.1 0.4 0.01 16.2 0.4 1.4 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 EFC49963.1 - 0.073 13.4 0.4 0.15 12.3 0.4 1.6 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Apt1 PF10351.9 EFC49963.1 - 1.4 7.7 9.0 1.6 7.5 9.0 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 EFC49963.1 - 2.4 7.3 16.4 2.8 7.0 16.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Presenilin PF01080.17 EFC49963.1 - 4.6 5.9 6.8 5.1 5.8 6.8 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 EFC49963.1 - 7.1 4.6 7.1 7.4 4.6 7.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ctr PF04145.15 EFC49964.1 - 9.8e-14 52.2 23.2 8.2e-08 33.0 10.7 2.5 2 1 1 3 3 3 2 Ctr copper transporter family DEAD PF00270.29 EFC49965.1 - 3.1e-41 141.1 0.0 7.9e-41 139.7 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC49965.1 - 2.5e-24 85.7 4.3 2.6e-24 85.7 0.0 3.2 4 1 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC49965.1 - 4.9e-05 23.4 7.6 0.00015 21.8 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit IMCp PF12314.8 EFC49965.1 - 0.001 19.3 5.8 0.004 17.4 5.8 2.0 1 0 0 1 1 1 1 Inner membrane complex protein IU_nuc_hydro PF01156.19 EFC49966.1 - 7.1e-23 81.6 0.0 8.3e-23 81.4 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PPR_2 PF13041.6 EFC49967.1 - 2.8e-18 65.8 6.4 2.7e-06 27.5 0.0 6.2 4 2 2 6 6 6 5 PPR repeat family PPR_3 PF13812.6 EFC49967.1 - 1.7e-16 60.1 9.6 9.2e-07 28.9 0.2 6.7 5 1 0 6 6 6 5 Pentatricopeptide repeat domain PPR PF01535.20 EFC49967.1 - 1.4e-15 56.3 0.7 0.011 16.0 0.0 7.1 8 0 0 8 8 8 4 PPR repeat PPR_long PF17177.4 EFC49967.1 - 0.00076 18.9 3.8 0.45 9.8 0.0 3.7 2 1 0 4 4 4 2 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 EFC49967.1 - 0.48 10.2 7.4 2.4 7.9 0.0 4.8 6 1 0 6 6 6 0 PPR repeat IFRD PF05004.13 EFC49969.1 - 0.025 13.7 0.1 0.05 12.7 0.0 1.5 1 1 0 1 1 1 0 Interferon-related developmental regulator (IFRD) PRP1_N PF06424.12 EFC49970.1 - 8.2e-40 136.6 1.2 2.4e-39 135.1 1.2 1.8 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 EFC49970.1 - 9.7e-18 63.4 0.7 0.4 11.6 0.0 10.1 9 2 2 11 11 11 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49970.1 - 5.1e-09 36.5 6.5 0.027 15.0 0.1 6.7 10 1 0 10 10 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49970.1 - 4.3e-07 29.9 4.5 2.8 8.5 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49970.1 - 3.5e-05 23.6 6.9 0.2 11.9 0.0 6.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC49970.1 - 0.0024 17.5 0.5 8.7 6.1 0.0 5.6 6 0 0 6 6 6 1 TPR repeat TPR_1 PF00515.28 EFC49970.1 - 0.0058 16.4 0.2 0.13 12.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat NADH_dh_m_C1 PF15088.6 EFC49970.1 - 0.0065 16.1 0.4 0.13 11.9 0.0 3.0 3 0 0 3 3 3 1 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Suf PF05843.14 EFC49970.1 - 0.031 14.3 9.1 0.26 11.2 0.1 4.3 4 0 0 4 4 4 0 Suppressor of forked protein (Suf) TPR_16 PF13432.6 EFC49970.1 - 0.085 13.5 0.0 17 6.2 0.0 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC49970.1 - 0.33 11.3 16.1 1.3 9.4 0.1 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat C4 PF01413.19 EFC49970.1 - 0.43 11.0 11.4 1.3 9.4 1.2 3.1 3 0 0 3 3 3 0 C-terminal tandem repeated domain in type 4 procollagen Esterase PF00756.20 EFC49972.1 - 1.3e-47 162.5 0.0 1.7e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 EFC49972.1 - 0.0012 18.3 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase_phd PF10503.9 EFC49972.1 - 0.092 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase Hydrolase_4 PF12146.8 EFC49972.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.4 1 1 0 1 1 1 0 Serine aminopeptidase, S33 PPR_2 PF13041.6 EFC49973.1 - 3.8e-09 36.6 0.5 2.2e-05 24.5 0.0 2.3 1 1 1 2 2 2 2 PPR repeat family PPR_3 PF13812.6 EFC49973.1 - 0.0043 17.1 0.2 0.033 14.3 0.0 2.2 1 1 1 2 2 2 1 Pentatricopeptide repeat domain PPR PF01535.20 EFC49973.1 - 0.016 15.4 0.0 0.059 13.7 0.0 1.9 2 0 0 2 2 2 0 PPR repeat DUF4464 PF14713.6 EFC49973.1 - 0.17 11.4 3.9 5.9 6.4 0.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4464) polyprenyl_synt PF00348.17 EFC49975.1 - 2.1e-82 276.0 0.0 2.6e-82 275.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Com_YlbF PF06133.11 EFC49975.1 - 0.067 13.8 3.0 0.14 12.7 3.0 1.6 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA DAGK_cat PF00781.24 EFC49976.1 - 5e-11 42.3 0.0 8.1e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain PFK PF00365.20 EFC49976.1 - 0.039 13.3 0.0 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 Phosphofructokinase WD40 PF00400.32 EFC49977.1 - 1.4e-52 174.5 25.9 5.8e-09 36.4 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC49977.1 - 8.1e-09 35.7 1.8 0.051 13.9 0.0 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain DUF1513 PF07433.11 EFC49977.1 - 0.0013 17.9 0.0 1.1 8.2 0.0 2.5 2 1 1 3 3 3 2 Protein of unknown function (DUF1513) WD40_like PF17005.5 EFC49977.1 - 0.035 13.4 0.0 0.18 11.1 0.0 1.9 1 1 0 1 1 1 0 WD40-like domain Nup160 PF11715.8 EFC49977.1 - 0.038 12.6 11.5 0.057 12.0 0.1 4.4 3 2 1 5 5 5 0 Nucleoporin Nup120/160 Sel1 PF08238.12 EFC49978.1 - 1.9e-56 187.2 15.7 3.6e-08 33.8 0.1 11.6 11 0 0 11 11 11 11 Sel1 repeat TPR_7 PF13176.6 EFC49978.1 - 1.3e-09 37.4 7.3 0.0027 17.6 0.1 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC49978.1 - 1.8e-07 30.7 15.8 0.012 15.7 0.2 8.6 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC49978.1 - 5.9e-07 29.7 12.4 0.0066 16.7 0.4 6.5 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 EFC49978.1 - 3.5e-05 23.9 12.4 4.1 8.0 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC49978.1 - 5.3e-05 22.9 17.0 0.19 11.6 0.1 7.4 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC49978.1 - 0.00016 21.3 0.3 0.0014 18.4 0.2 8.2 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC49978.1 - 0.00033 21.1 4.0 0.9 10.3 0.0 5.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC49978.1 - 0.00041 20.9 2.0 0.12 13.2 0.0 4.0 5 0 0 5 5 2 1 Tetratricopeptide repeat DUF5112 PF17139.4 EFC49978.1 - 0.0053 16.3 5.8 0.0088 15.6 0.1 3.6 3 1 2 5 5 5 1 Domain of unknown function (DUF5112) TPR_8 PF13181.6 EFC49978.1 - 0.011 15.9 20.3 0.15 12.3 0.0 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC49978.1 - 0.033 14.8 4.2 5 7.9 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC49978.1 - 0.041 14.4 5.9 0.72 10.4 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Vps39_1 PF10366.9 EFC49978.1 - 0.61 10.4 4.3 3.1 8.1 0.1 3.7 4 0 0 4 4 4 0 Vacuolar sorting protein 39 domain 1 Kri1_C PF12936.7 EFC49979.1 - 1.1e-16 60.7 3.1 1.1e-16 60.7 3.1 4.9 4 1 1 5 5 5 1 KRI1-like family C-terminal Kin17_mid PF10357.9 EFC49980.1 - 1.5e-40 138.0 1.9 1.5e-40 138.0 1.9 2.4 2 0 0 2 2 2 1 Domain of Kin17 curved DNA-binding protein KN17_SH3 PF18131.1 EFC49980.1 - 2.8e-07 30.5 0.4 7.5e-07 29.2 0.4 1.7 1 0 0 1 1 1 1 KN17 SH3-like C-terminal domain zf-C2H2_jaz PF12171.8 EFC49980.1 - 7.3e-05 22.9 2.1 0.00023 21.3 2.1 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 EFC49980.1 - 0.0088 16.4 3.1 0.0089 16.4 1.3 2.1 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 EFC49980.1 - 0.026 14.8 0.4 0.026 14.8 0.4 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) TFIID_NTD2 PF04494.15 EFC49980.1 - 0.095 12.9 2.2 0.48 10.6 0.2 2.5 2 0 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain TPX2_importin PF12214.8 EFC49980.1 - 0.12 12.5 5.2 0.06 13.6 2.9 1.7 2 0 0 2 2 2 0 Cell cycle regulated microtubule associated protein Orthopox_B11R PF07033.11 EFC49980.1 - 1 9.2 4.4 1.4 8.7 3.0 1.9 1 1 0 1 1 1 0 Orthopoxvirus B11R protein zf-DBF PF07535.12 EFC49980.1 - 9 6.5 7.0 3.5 7.8 0.5 3.0 3 0 0 3 3 3 0 DBF zinc finger Utp12 PF04003.12 EFC49981.1 - 3.9e-19 68.9 0.5 1.2e-18 67.3 0.5 1.9 1 0 0 1 1 1 1 Dip2/Utp12 Family Sec7_N PF12783.7 EFC49981.1 - 0.0019 18.1 0.4 0.011 15.7 0.3 2.0 1 1 1 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal PQQ_2 PF13360.6 EFC49981.1 - 0.0081 15.8 0.0 0.07 12.7 0.0 2.1 2 0 0 2 2 2 1 PQQ-like domain CoA_binding_3 PF13727.6 EFC49981.1 - 0.19 11.7 0.2 0.9 9.5 0.0 2.0 2 0 0 2 2 2 0 CoA-binding domain BUD22 PF09073.10 EFC49981.1 - 0.27 10.5 18.8 0.46 9.8 18.8 1.4 1 0 0 1 1 1 0 BUD22 Alg6_Alg8 PF03155.15 EFC49982.1 - 3e-119 399.2 41.3 4.5e-119 398.6 41.3 1.2 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Methyltr_RsmB-F PF01189.17 EFC49983.1 - 4.1e-69 232.2 0.0 1.3e-68 230.6 0.0 1.9 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 EFC49983.1 - 2.8e-07 31.0 0.1 1.5e-06 28.6 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 EFC49983.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase Ras PF00071.22 EFC49984.1 - 4.1e-48 163.0 0.8 5.4e-48 162.6 0.8 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC49984.1 - 6.7e-26 90.9 0.4 2.2e-25 89.2 0.1 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC49984.1 - 4.4e-08 32.8 0.1 6.3e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC49984.1 - 0.00051 20.0 0.1 0.31 10.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 EFC49984.1 - 0.0018 18.3 0.1 0.003 17.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 EFC49984.1 - 0.026 14.1 0.1 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 EFC49984.1 - 0.054 13.2 0.4 0.15 11.8 0.4 1.9 1 1 0 1 1 1 0 AAA domain D123 PF07065.14 EFC49985.1 - 4.1e-18 65.6 0.8 4.7e-18 65.4 0.8 1.2 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 EFC49985.1 - 0.00063 19.8 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 EFC49985.1 - 0.0021 17.9 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 FAT PF02259.23 EFC49986.1 - 4.1e-29 101.9 8.8 4.1e-29 101.9 8.8 3.3 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 EFC49986.1 - 1.2e-19 71.2 3.6 2.2e-19 70.3 1.2 2.9 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 EFC49986.1 - 0.067 13.0 0.0 0.2 11.5 0.0 1.9 1 0 0 1 1 1 0 FATC domain Glucosamine_iso PF01182.20 EFC49987.1 - 1.3e-23 84.1 0.0 2.3e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase PIG-L PF02585.17 EFC49987.1 - 2.4e-12 47.6 0.0 2.4e-11 44.4 0.0 2.4 1 1 0 1 1 1 1 GlcNAc-PI de-N-acetylase FA_desaturase PF00487.24 EFC49988.1 - 6.7e-33 114.6 20.2 6.7e-33 114.6 20.2 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFC49988.1 - 1.7e-19 69.7 0.1 3.3e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SK_channel PF03530.14 EFC49988.1 - 0.16 12.0 0.1 0.16 12.0 0.1 2.0 2 0 0 2 2 2 0 Calcium-activated SK potassium channel YEATS PF03366.16 EFC49989.1 - 7.3e-23 80.3 0.0 1.6e-22 79.2 0.0 1.6 1 0 0 1 1 1 1 YEATS family DUF4407 PF14362.6 EFC49989.1 - 3.5 6.9 6.9 5.2 6.3 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 EFC49989.1 - 6.4 4.6 10.7 9.3 4.0 10.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YchF-GTPase_C PF06071.13 EFC49990.1 - 2.4e-38 130.2 0.4 5.2e-38 129.1 0.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 EFC49990.1 - 2.2e-22 79.3 0.0 5.2e-22 78.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC49990.1 - 5.8e-07 29.2 0.0 1.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 EFC49990.1 - 0.054 13.7 0.0 2.1 8.6 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2829 PF11195.8 EFC49990.1 - 0.062 13.6 0.1 0.24 11.7 0.1 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2829) MeaB PF03308.16 EFC49990.1 - 0.093 11.7 0.1 0.22 10.4 0.0 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB POP1 PF06978.11 EFC49991.1 - 1.3e-24 87.4 22.3 1.8e-12 47.7 2.1 2.5 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 EFC49991.1 - 5.1e-06 26.7 0.0 2.2e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 POPLD (NUC188) domain GCV_T_C PF08669.11 EFC49991.1 - 0.0048 16.8 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain DUF382 PF04037.13 EFC49991.1 - 0.62 10.2 4.5 0.48 10.6 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF382) Methyltransf_3 PF01596.17 EFC49992.1 - 7.9e-51 172.2 0.1 9.2e-51 172.0 0.1 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 EFC49992.1 - 8.6e-13 49.2 0.1 3.2e-12 47.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC49992.1 - 3.1e-07 30.3 0.0 4.2e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC49992.1 - 6.6e-07 30.0 0.0 1.1e-06 29.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 EFC49992.1 - 4.2e-06 26.7 0.0 5.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 EFC49992.1 - 0.00011 21.9 0.0 0.00017 21.3 0.0 1.4 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 EFC49992.1 - 0.0014 19.3 0.0 0.0025 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 EFC49992.1 - 0.0018 17.6 0.0 0.0026 17.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 EFC49992.1 - 0.0092 15.8 0.0 0.025 14.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 EFC49992.1 - 0.01 15.8 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain CmcI PF04989.12 EFC49992.1 - 0.016 14.9 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Cephalosporin hydroxylase MTS PF05175.14 EFC49992.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_12 PF08242.12 EFC49992.1 - 0.051 14.3 0.3 0.22 12.3 0.3 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 EFC49992.1 - 0.082 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF2207 PF09972.9 EFC49993.1 - 0.091 11.5 2.3 0.17 10.6 2.3 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4748 PF15932.5 EFC49993.1 - 0.5 10.1 3.9 0.56 10.0 1.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4748) DUF4083 PF13314.6 EFC49994.1 - 0.26 11.3 1.1 3.5 7.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) NT5C PF06941.12 EFC49995.1 - 4.8e-06 26.6 0.1 3.3e-05 23.8 0.1 2.0 1 1 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) NIF PF03031.18 EFC49995.1 - 0.036 13.8 0.1 0.087 12.6 0.0 1.6 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase PA28_alpha PF02251.18 EFC49995.1 - 0.05 13.7 0.9 0.31 11.1 0.1 2.5 3 0 0 3 3 3 0 Proteasome activator pa28 alpha subunit HAD_2 PF13419.6 EFC49995.1 - 0.064 13.3 0.2 0.11 12.6 0.2 1.6 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DMAP1_like PF17024.5 EFC49995.1 - 0.07 13.3 2.5 0.095 12.8 0.7 2.1 2 1 1 3 3 3 0 Putative DMAP1-like DAO PF01266.24 EFC49996.1 - 2.2e-45 155.8 0.0 3.2e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 EFC49996.1 - 4.4e-31 107.4 0.0 6.7e-31 106.8 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 EFC49996.1 - 1e-10 41.3 0.5 6e-06 25.6 0.3 2.1 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 EFC49996.1 - 2.2e-09 37.2 0.2 1.6e-07 31.1 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 EFC49996.1 - 1.7e-05 24.1 1.7 0.0003 20.0 0.3 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 EFC49996.1 - 2.7e-05 23.6 0.0 0.0007 18.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 EFC49996.1 - 0.00065 19.0 0.0 0.00096 18.5 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 EFC49996.1 - 0.00066 19.0 0.0 0.0022 17.3 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 EFC49996.1 - 0.00077 19.6 0.2 0.0048 17.1 0.5 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 EFC49996.1 - 0.001 17.8 0.1 0.0018 17.0 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 EFC49996.1 - 0.0017 18.9 1.2 0.0032 18.0 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 EFC49996.1 - 0.068 13.1 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 EFC49996.1 - 0.15 11.3 0.1 0.3 10.3 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Triabin PF03973.13 EFC49998.1 - 3.9e-10 39.8 0.3 6.3e-10 39.1 0.3 1.3 1 0 0 1 1 1 1 Triabin Lipocalin PF00061.23 EFC49998.1 - 1.3e-09 38.4 0.2 1.9e-09 37.9 0.2 1.3 1 0 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Lipocalin_2 PF08212.12 EFC49998.1 - 8.2e-08 32.3 0.1 1.8e-07 31.2 0.1 1.5 1 1 0 1 1 1 1 Lipocalin-like domain VDE PF07137.11 EFC49998.1 - 0.0057 16.2 0.1 0.0068 16.0 0.1 1.2 1 0 0 1 1 1 1 VDE lipocalin domain TRAP-gamma PF07074.12 EFC49998.1 - 0.058 13.0 0.1 0.058 13.0 0.1 1.6 2 0 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) ATP-synt_I PF03899.15 EFC49999.1 - 0.028 14.8 3.2 0.035 14.5 3.2 1.1 1 0 0 1 1 1 0 ATP synthase I chain DUF846 PF05832.12 EFC49999.1 - 0.032 14.3 0.5 0.032 14.3 0.5 2.0 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF846) ECF_trnsprt PF12822.7 EFC49999.1 - 0.08 13.0 4.7 0.097 12.8 4.7 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component zf-LITAF-like PF10601.9 EFC49999.1 - 0.29 11.4 0.2 0.29 11.4 0.2 1.9 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain Renin_r PF07850.14 EFC49999.1 - 5.8 7.6 5.7 1.8 9.3 2.5 1.8 1 1 1 2 2 2 0 Renin receptor-like protein CobW_C PF07683.14 EFC50000.1 - 9.7e-19 67.1 0.0 1.6e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain cobW PF02492.19 EFC50000.1 - 1.8e-07 30.9 4.1 2.8e-06 27.1 4.1 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Mito_carr PF00153.27 EFC50001.1 - 1.7e-69 229.8 0.8 1.2e-23 82.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-DBF PF07535.12 EFC50002.1 - 0.00044 20.3 0.5 0.0014 18.7 0.5 1.9 1 0 0 1 1 1 1 DBF zinc finger T4-Gluco-transf PF09198.10 EFC50002.1 - 0.021 14.4 0.3 0.27 10.9 0.2 2.7 2 0 0 2 2 2 0 Bacteriophage T4 beta-glucosyltransferase DUF272 PF03312.15 EFC50003.1 - 0.04 14.1 0.2 0.18 12.1 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF272) ASC PF00858.24 EFC50004.1 - 6.6e-15 55.0 6.4 3.1e-08 33.0 0.1 3.0 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel DUF4679 PF15728.5 EFC50005.1 - 0.38 9.7 11.0 0.071 12.1 7.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4679) FA_FANCE PF11510.8 EFC50006.1 - 3.7e-06 26.5 3.3 5.2e-06 26.0 3.3 1.2 1 0 0 1 1 1 1 Fanconi Anaemia group E protein FANCE Utp12 PF04003.12 EFC50006.1 - 0.047 14.0 4.4 0.17 12.2 0.0 2.8 2 1 0 2 2 2 0 Dip2/Utp12 Family WD40_3 PF15911.5 EFC50007.1 - 1.5e-23 82.5 0.1 4.8e-23 80.9 0.1 1.9 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50007.1 - 2e-09 37.6 0.3 0.063 13.6 0.0 5.5 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain TPR_7 PF13176.6 EFC50007.1 - 4.5e-07 29.4 11.8 3.1 8.0 0.3 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 EFC50007.1 - 1.4e-05 24.3 0.7 1.4e-05 24.3 0.7 6.1 4 2 3 7 7 7 2 Coatomer WD associated region Clathrin PF00637.20 EFC50007.1 - 3.6e-05 23.7 5.8 3.6e-05 23.7 5.8 5.3 3 1 3 6 6 6 3 Region in Clathrin and VPS TPR_14 PF13428.6 EFC50007.1 - 4.8e-05 23.8 5.9 9.6 7.3 0.1 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat Rad50_zn_hook PF04423.14 EFC50007.1 - 0.00046 20.0 0.7 0.082 12.8 0.0 3.5 3 0 0 3 3 3 1 Rad50 zinc hook motif TPR_2 PF07719.17 EFC50007.1 - 0.00088 19.2 19.0 2.1 8.7 0.3 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat eIF2A PF08662.11 EFC50007.1 - 0.0012 18.8 0.8 0.007 16.3 0.2 2.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC3 PF12895.7 EFC50007.1 - 0.06 13.6 12.0 0.11 12.8 3.0 4.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC50007.1 - 0.15 12.6 7.0 27 5.4 0.0 4.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50007.1 - 0.65 10.3 10.0 1e+02 3.3 0.2 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DZR PF12773.7 EFC50007.1 - 2 8.5 13.5 5.5 7.1 10.4 2.9 2 1 0 2 2 2 0 Double zinc ribbon zf-Di19 PF05605.12 EFC50007.1 - 4.7 7.6 11.9 2.6 8.4 2.5 2.8 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Nop14 PF04147.12 EFC50008.1 - 9.1e-31 106.9 96.9 2.4e-26 92.3 96.9 3.3 1 1 0 1 1 1 1 Nop14-like family AAA_28 PF13521.6 EFC50009.1 - 3.9e-26 92.2 0.0 8.9e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 EFC50009.1 - 7.4e-05 21.9 0.0 0.00011 21.3 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB KTI12 PF08433.10 EFC50009.1 - 0.00021 20.8 0.1 0.0013 18.3 0.0 2.2 2 0 0 2 2 2 1 Chromatin associated protein KTI12 AAA_30 PF13604.6 EFC50009.1 - 0.0091 15.7 0.0 0.081 12.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFC50009.1 - 0.022 15.3 0.1 0.092 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain Beta-Casp PF10996.8 EFC50010.1 - 4.3e-26 91.4 0.0 8.7e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 EFC50010.1 - 3.1e-22 79.0 0.0 6.7e-22 77.9 0.0 1.5 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 EFC50010.1 - 4.2e-18 65.0 0.0 8.2e-18 64.1 0.0 1.5 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 EFC50010.1 - 1.5e-11 44.7 0.0 3.7e-11 43.4 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 EFC50010.1 - 2.9e-09 36.7 0.2 1.9e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC50010.1 - 0.00016 21.6 0.0 0.00052 19.9 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain PBP5_C PF07943.13 EFC50010.1 - 0.13 12.5 0.0 0.35 11.1 0.0 1.7 1 0 0 1 1 1 0 Penicillin-binding protein 5, C-terminal domain GNT-I PF03071.15 EFC50011.1 - 2.9e-45 154.8 6.0 1.1e-43 149.6 6.0 2.0 1 1 0 1 1 1 1 GNT-I family Glyco_transf_18 PF15024.6 EFC50011.1 - 0.0013 17.5 7.7 0.0017 17.0 7.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 Glyco_tranf_2_3 PF13641.6 EFC50011.1 - 0.0096 15.8 0.0 0.016 15.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Peptidase_A22B PF04258.13 EFC50012.1 - 3e-83 279.6 13.6 3.8e-83 279.3 13.6 1.0 1 0 0 1 1 1 1 Signal peptide peptidase P2X_receptor PF00864.19 EFC50012.1 - 0.093 11.8 0.2 0.15 11.1 0.2 1.3 1 0 0 1 1 1 0 ATP P2X receptor Presenilin PF01080.17 EFC50012.1 - 2 7.1 7.6 0.1 11.3 1.8 1.8 2 0 0 2 2 2 0 Presenilin SANTA PF09133.10 EFC50013.1 - 5e-10 39.7 0.0 1.3e-09 38.4 0.0 1.8 1 0 0 1 1 1 1 SANTA (SANT Associated) LRR_6 PF13516.6 EFC50014.1 - 1.8e-17 61.8 9.8 3.5e-05 23.5 0.0 8.6 9 0 0 9 9 9 7 Leucine Rich repeat LRR_4 PF12799.7 EFC50014.1 - 4e-14 52.5 4.6 0.0028 18.0 0.0 5.7 3 1 1 5 5 5 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC50014.1 - 1.6e-05 24.8 20.4 0.076 13.6 0.1 7.8 7 3 0 7 7 7 2 Leucine Rich Repeat DUF1569 PF07606.11 EFC50014.1 - 0.015 15.3 0.0 3.5 7.6 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1569) WD40 PF00400.32 EFC50015.1 - 5.5e-32 109.3 47.6 0.0022 18.8 0.0 18.4 21 0 0 21 21 21 7 WD domain, G-beta repeat DUF667 PF05018.13 EFC50015.1 - 4.2e-26 91.8 1.0 6.2e-26 91.3 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF667) ANAPC4_WD40 PF12894.7 EFC50015.1 - 1.7e-11 44.2 7.6 0.24 11.7 0.0 10.7 8 4 4 13 13 13 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 EFC50015.1 - 6e-05 21.9 2.0 0.084 11.5 0.0 3.9 4 0 0 4 4 4 2 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 EFC50015.1 - 0.0055 16.0 0.2 0.18 11.0 0.0 3.1 3 0 0 3 3 3 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Proteasom_Rpn13 PF04683.13 EFC50015.1 - 0.032 14.8 0.2 0.24 12.0 0.2 2.6 1 0 0 1 1 1 0 Proteasome complex subunit Rpn13 ubiquitin receptor Plk4_PB1 PF18190.1 EFC50015.1 - 0.064 13.4 0.2 20 5.4 0.2 2.9 2 0 0 2 2 2 0 Polo-like Kinase 4 Polo Box 1 SAC3_GANP PF03399.16 EFC50016.1 - 1.6e-94 316.6 0.9 2.7e-94 315.8 0.9 1.4 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 EFC50016.1 - 3.2e-08 33.6 0.1 1.3e-07 31.7 0.0 2.1 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family TRAPPC9-Trs120 PF08626.11 EFC50017.1 - 3.2e-34 117.6 22.1 1.4e-19 69.1 4.5 4.1 1 1 3 4 4 4 3 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit DUF1249 PF06853.12 EFC50017.1 - 0.1 12.6 0.0 0.36 10.9 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1249) LANC_like PF05147.13 EFC50017.1 - 0.12 10.9 2.2 0.15 10.6 1.1 1.7 2 0 0 2 2 2 0 Lanthionine synthetase C-like protein Pribosyltran PF00156.27 EFC50018.1 - 1.4e-23 83.2 0.1 1.7e-23 82.9 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 EFC50018.1 - 0.01 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 EFC50018.1 - 0.019 14.5 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase PKD_channel PF08016.12 EFC50019.1 - 1.8e-10 40.1 11.8 3.4e-10 39.2 11.8 1.4 1 0 0 1 1 1 1 Polycystin cation channel NHL PF01436.21 EFC50019.1 - 0.00091 19.2 0.1 0.013 15.5 0.0 3.0 4 0 0 4 4 4 1 NHL repeat DUF1030 PF06270.11 EFC50019.1 - 0.24 11.2 2.1 0.59 9.9 2.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1030) LCD1 PF09798.9 EFC50020.1 - 0.016 13.8 2.0 0.019 13.5 2.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF1178 PF06676.11 EFC50020.1 - 0.042 14.3 3.4 0.058 13.8 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) Rtf2 PF04641.12 EFC50020.1 - 0.45 9.8 9.1 0.67 9.3 9.1 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Spore_coat_CotO PF14153.6 EFC50020.1 - 0.61 10.0 16.8 0.41 10.6 15.5 1.3 1 1 0 1 1 1 0 Spore coat protein CotO RR_TM4-6 PF06459.12 EFC50020.1 - 3.9 7.2 13.0 0.28 11.0 8.5 1.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CLASP_N PF12348.8 EFC50021.1 - 2.2e-51 174.6 9.8 1.2e-36 126.4 0.8 3.8 4 1 0 4 4 4 3 CLASP N terminal HEAT PF02985.22 EFC50021.1 - 1.3e-19 68.6 2.3 0.027 14.7 0.0 11.0 11 0 0 11 11 11 4 HEAT repeat Cnd1 PF12717.7 EFC50021.1 - 2.2e-10 40.8 9.8 0.054 13.5 0.4 6.6 5 3 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC50021.1 - 0.00053 20.3 0.0 1.1 9.7 0.0 5.5 5 2 1 6 6 6 1 HEAT repeats Cohesin_HEAT PF12765.7 EFC50021.1 - 0.0017 18.6 3.0 17 5.8 0.4 5.0 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion Band_3_cyto PF07565.13 EFC50021.1 - 0.0018 18.1 0.1 0.0055 16.6 0.1 1.8 1 0 0 1 1 1 1 Band 3 cytoplasmic domain HEAT_EZ PF13513.6 EFC50021.1 - 0.004 17.6 0.0 10 6.8 0.0 4.9 6 0 0 6 6 6 1 HEAT-like repeat RasGEF_N_2 PF14663.6 EFC50021.1 - 0.0043 17.4 2.1 2.6 8.5 0.3 3.6 2 1 1 3 3 3 2 Rapamycin-insensitive companion of mTOR RasGEF_N domain NUC173 PF08161.12 EFC50021.1 - 1.6 8.3 4.6 2.1 8.0 0.1 3.3 4 0 0 4 4 4 0 NUC173 domain UPF0020 PF01170.18 EFC50022.1 - 1.8e-21 76.8 0.0 2.1e-20 73.3 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 EFC50022.1 - 1e-08 35.8 0.0 4.3e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC50022.1 - 5.6e-07 29.5 0.0 1.5e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC50022.1 - 5.1e-05 23.8 0.0 0.0002 21.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 EFC50022.1 - 6.2e-05 22.6 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain AviRa PF11599.8 EFC50022.1 - 0.00019 21.0 0.0 0.00049 19.6 0.0 1.8 1 0 0 1 1 1 1 RRNA methyltransferase AviRa Ubie_methyltran PF01209.18 EFC50022.1 - 0.001 18.5 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 EFC50022.1 - 0.037 13.5 0.0 0.089 12.3 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase PCMT PF01135.19 EFC50022.1 - 0.04 13.7 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PH PF00169.29 EFC50023.1 - 5.1e-17 62.3 0.5 1.1e-16 61.2 0.5 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 EFC50023.1 - 1.4e-06 28.7 4.1 6.3e-05 23.3 0.1 3.1 2 1 2 4 4 4 2 Pleckstrin homology domain PH_8 PF15409.6 EFC50023.1 - 2.8e-06 27.5 0.1 4.6e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 EFC50023.1 - 0.00012 22.5 1.0 0.003 17.9 0.4 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 EFC50023.1 - 0.014 15.5 0.1 0.027 14.6 0.1 1.5 1 0 0 1 1 1 0 PH domain PH_16 PF17838.1 EFC50023.1 - 0.057 13.3 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 PH domain WH2 PF02205.20 EFC50024.1 - 9.8e-08 31.6 0.4 2.2e-07 30.5 0.4 1.7 1 0 0 1 1 1 1 WH2 motif Acyl_transf_1 PF00698.21 EFC50025.1 - 3.6e-12 46.4 0.4 2e-11 44.0 0.4 2.1 1 1 0 1 1 1 1 Acyl transferase domain MMS1_N PF10433.9 EFC50026.1 - 1.9e-147 491.8 0.2 1.3e-146 489.1 0.0 2.3 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 EFC50026.1 - 7.5e-97 324.5 0.1 1.6e-94 316.8 0.0 3.4 3 0 0 3 3 3 1 CPSF A subunit region BBS2_N PF14781.6 EFC50026.1 - 0.039 13.8 0.3 4.6 7.2 0.0 4.0 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, N-terminal SR-25 PF10500.9 EFC50027.1 - 0.047 13.3 7.0 0.062 12.9 7.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein adh_short PF00106.25 EFC50028.1 - 2.9e-40 137.8 0.1 3.8e-40 137.4 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 EFC50028.1 - 1.1e-22 80.8 0.0 1.5e-22 80.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 EFC50028.1 - 9e-09 35.5 0.1 1.9e-08 34.4 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 EFC50028.1 - 0.0015 18.0 0.2 0.019 14.4 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 EFC50028.1 - 0.012 14.7 0.1 0.018 14.2 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein RRF PF01765.19 EFC50029.1 - 2.8e-48 163.9 9.3 3.2e-48 163.7 9.3 1.0 1 0 0 1 1 1 1 Ribosome recycling factor YtxH PF12732.7 EFC50029.1 - 0.028 14.9 3.9 0.071 13.6 3.9 1.7 1 0 0 1 1 1 0 YtxH-like protein REF PF05755.12 EFC50029.1 - 0.054 13.3 0.1 0.083 12.7 0.1 1.3 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) FtsX PF02687.21 EFC50030.1 - 9.1e-18 64.5 25.0 3.1e-11 43.6 7.7 6.6 6 1 0 6 6 6 2 FtsX-like permease family RhoGEF PF00621.20 EFC50031.1 - 1.5e-35 123.1 1.1 1.5e-35 123.1 1.1 4.3 4 0 0 4 4 4 1 RhoGEF domain TBCC PF07986.12 EFC50031.1 - 3.8e-24 84.7 9.6 3.8e-24 84.7 9.6 2.0 2 0 0 2 2 2 1 Tubulin binding cofactor C Arm PF00514.23 EFC50031.1 - 4.1e-09 36.2 0.1 3.1e-05 23.9 0.0 4.2 3 1 0 3 3 3 2 Armadillo/beta-catenin-like repeat CAP_C PF08603.11 EFC50031.1 - 0.00091 18.9 5.6 0.0026 17.4 5.6 1.7 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal Vac14_Fab1_bd PF12755.7 EFC50031.1 - 0.025 15.2 2.3 0.17 12.5 0.1 3.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Sec62 PF03839.16 EFC50031.1 - 5.9 6.3 14.9 16 4.9 14.9 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 Aminotran_3 PF00202.21 EFC50032.1 - 1e-87 294.4 0.0 1.3e-87 294.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III DUF5470 PF17564.2 EFC50032.1 - 0.1 12.8 0.1 0.86 9.8 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5470) AAA PF00004.29 EFC50033.1 - 2.3e-52 176.9 3.2 2.7e-35 121.7 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 EFC50033.1 - 2.9e-15 55.8 1.0 6.1e-15 54.8 0.2 2.0 2 0 0 2 2 1 1 AAA+ lid domain AAA_16 PF13191.6 EFC50033.1 - 3.3e-11 43.9 0.0 0.00057 20.3 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFC50033.1 - 8.2e-10 39.1 5.0 3.6e-05 24.0 1.9 4.1 3 2 1 4 4 2 2 AAA domain Sigma54_activat PF00158.26 EFC50033.1 - 6.8e-07 29.1 0.0 0.029 14.1 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 EFC50033.1 - 1.5e-06 27.9 0.0 0.0097 15.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region RuvB_N PF05496.12 EFC50033.1 - 1.9e-06 27.7 0.0 0.0014 18.4 0.0 3.1 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 EFC50033.1 - 2.7e-06 28.0 0.7 0.0026 18.3 0.0 3.2 2 1 0 2 2 2 1 ABC transporter AAA_2 PF07724.14 EFC50033.1 - 3.4e-06 27.3 0.9 0.036 14.2 0.5 3.4 3 0 0 3 3 3 2 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 EFC50033.1 - 9e-06 26.0 0.6 0.088 13.2 0.0 3.7 3 0 0 3 3 3 1 RNA helicase AAA_5 PF07728.14 EFC50033.1 - 9.9e-06 25.6 0.0 0.027 14.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 EFC50033.1 - 1.1e-05 25.5 1.3 0.13 12.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.6 EFC50033.1 - 3.4e-05 23.5 0.1 0.82 9.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain NB-ARC PF00931.22 EFC50033.1 - 3.5e-05 23.1 0.5 0.15 11.2 0.0 3.0 3 1 0 3 3 3 2 NB-ARC domain AAA_29 PF13555.6 EFC50033.1 - 4.3e-05 23.2 0.0 0.018 14.8 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 EFC50033.1 - 4.5e-05 23.4 0.9 0.4 10.6 0.0 3.5 2 2 1 3 3 3 2 NACHT domain NTPase_1 PF03266.15 EFC50033.1 - 4.5e-05 23.4 0.3 0.16 11.8 0.1 2.7 2 0 0 2 2 2 2 NTPase AAA_18 PF13238.6 EFC50033.1 - 8.1e-05 23.2 0.5 0.39 11.3 0.1 3.3 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 EFC50033.1 - 9.4e-05 22.2 0.0 0.18 11.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_24 PF13479.6 EFC50033.1 - 0.0001 22.1 0.6 0.17 11.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 EFC50033.1 - 0.00039 19.6 0.0 0.015 14.3 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 EFC50033.1 - 0.00058 19.8 0.8 1.7 8.5 0.0 3.3 3 1 0 3 3 3 2 RsgA GTPase ATPase_2 PF01637.18 EFC50033.1 - 0.0013 18.7 9.4 0.12 12.3 1.0 3.6 3 2 0 3 3 3 2 ATPase domain predominantly from Archaea SRP54 PF00448.22 EFC50033.1 - 0.0023 17.6 0.1 0.66 9.6 0.0 2.9 3 0 0 3 3 2 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 EFC50033.1 - 0.004 17.3 0.0 0.06 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 EFC50033.1 - 0.0044 16.3 4.2 0.056 12.6 0.0 2.6 3 0 0 3 3 2 1 TIP49 P-loop domain KAP_NTPase PF07693.14 EFC50033.1 - 0.005 16.1 1.4 0.3 10.3 0.0 3.2 2 1 0 3 3 3 1 KAP family P-loop domain TsaE PF02367.17 EFC50033.1 - 0.007 16.4 0.0 4 7.5 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 EFC50033.1 - 0.0077 16.8 0.5 0.0077 16.8 0.5 4.7 1 1 3 4 4 1 1 AAA domain AAA_19 PF13245.6 EFC50033.1 - 0.014 15.7 0.2 1.2 9.5 0.0 2.8 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.21 EFC50033.1 - 0.022 14.2 0.0 7.6 5.8 0.0 2.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 EFC50033.1 - 0.022 14.6 0.0 3.5 7.5 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EFC50033.1 - 0.025 13.9 1.5 3.6 6.9 0.1 3.3 2 1 1 3 3 3 0 KaiC Hpr_kinase_C PF07475.12 EFC50033.1 - 0.038 13.5 0.7 1.6 8.2 0.0 2.6 3 0 0 3 3 2 0 HPr Serine kinase C-terminal domain Thymidylate_kin PF02223.17 EFC50033.1 - 0.041 13.6 1.0 1.5 8.4 0.0 3.5 4 1 1 5 5 5 0 Thymidylate kinase ResIII PF04851.15 EFC50033.1 - 0.054 13.5 0.4 2.6 8.0 0.0 3.3 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit Roc PF08477.13 EFC50033.1 - 0.058 13.6 0.1 4.3 7.6 0.0 3.0 2 1 1 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC50033.1 - 0.076 13.1 0.0 22 5.2 0.0 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 EFC50033.1 - 0.09 12.9 7.3 2.3 8.3 0.2 4.3 3 2 2 5 5 5 0 Helicase HerA, central domain AAA_17 PF13207.6 EFC50033.1 - 0.12 12.8 0.2 4.3 7.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain RRM_1 PF00076.22 EFC50034.1 - 3.3e-13 49.2 0.0 6.5e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 EFC50034.1 - 0.017 14.7 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIEZO PF15917.5 EFC50034.1 - 0.035 13.6 0.2 0.072 12.6 0.2 1.4 1 0 0 1 1 1 0 Piezo 5_nucleotid_C PF02872.18 EFC50036.1 - 3e-28 99.0 0.0 4.9e-28 98.3 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Img2 PF05046.14 EFC50037.1 - 2.2e-20 72.7 0.0 3.8e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) LRR_6 PF13516.6 EFC50039.1 - 1.8e-45 149.2 8.1 1.7e-06 27.6 0.1 8.3 8 0 0 8 8 8 8 Leucine Rich repeat LRR_4 PF12799.7 EFC50039.1 - 2.7e-27 94.4 16.2 8.7e-06 26.0 0.1 5.4 1 1 7 8 8 8 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC50039.1 - 7.4e-27 92.9 2.6 1.7e-08 34.1 0.1 3.9 3 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 EFC50039.1 - 1e-16 58.9 0.0 1 10.1 0.0 8.6 9 0 0 9 9 9 4 Leucine Rich Repeat LRR_9 PF14580.6 EFC50039.1 - 4.7e-05 23.0 0.3 0.18 11.3 0.0 2.8 1 1 1 2 2 2 2 Leucine-rich repeat Beta_helix PF13229.6 EFC50039.1 - 0.00025 20.9 11.9 0.039 13.8 6.1 2.1 1 1 1 2 2 2 2 Right handed beta helix region Dynein_heavy PF03028.15 EFC50039.1 - 0.0037 17.3 0.1 0.0071 16.4 0.1 1.4 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain LRR_2 PF07723.13 EFC50039.1 - 0.16 12.7 0.1 2.2e+02 2.7 0.0 5.2 7 0 0 7 7 7 0 Leucine Rich Repeat ApoB100_C PF12491.8 EFC50039.1 - 0.18 11.8 5.3 2.1 8.3 0.3 4.1 3 1 2 5 5 5 0 Apolipoprotein B100 C terminal bZIP_C PF12498.8 EFC50039.1 - 0.24 12.4 1.9 5.4 8.0 0.2 3.0 1 1 2 3 3 3 0 Basic leucine-zipper C terminal MAPEG PF01124.18 EFC50040.1 - 8.4e-16 58.0 5.8 1e-15 57.8 5.8 1.1 1 0 0 1 1 1 1 MAPEG family EMG1 PF03587.14 EFC50041.1 - 5.8e-76 254.5 0.0 7.2e-76 254.2 0.0 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Methyltr_RsmB-F PF01189.17 EFC50042.1 - 3.5e-22 79.0 4.9 5.9e-12 45.6 0.0 4.1 5 0 0 5 5 5 3 16S rRNA methyltransferase RsmB/F DUF2652 PF10851.8 EFC50042.1 - 0.11 12.6 1.9 0.42 10.7 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2652) Sod_Fe_N PF00081.22 EFC50042.1 - 0.22 12.0 5.2 0.097 13.2 1.1 2.7 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, alpha-hairpin domain CsgF PF10614.9 EFC50042.1 - 0.79 9.9 8.6 0.55 10.4 3.7 3.0 3 0 0 3 3 3 0 Type VIII secretion system (T8SS), CsgF protein Ank_2 PF12796.7 EFC50043.1 - 3.9e-29 101.1 23.4 1.2e-07 32.2 0.4 6.7 5 1 1 7 7 7 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC50043.1 - 5.9e-20 71.4 17.3 1.4e-06 28.8 0.2 8.8 8 3 3 11 11 11 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC50043.1 - 7.3e-19 67.6 8.8 0.00099 19.4 0.1 8.8 7 2 3 10 10 10 4 Ankyrin repeats (many copies) Ank PF00023.30 EFC50043.1 - 5.1e-11 42.5 15.9 4.6e-05 23.7 0.1 9.3 9 1 0 9 9 9 2 Ankyrin repeat Ank_3 PF13606.6 EFC50043.1 - 1.2e-10 40.6 19.2 0.015 15.8 0.1 10.7 12 0 0 12 12 12 1 Ankyrin repeat UBA_4 PF14555.6 EFC50043.1 - 4.5e-05 23.2 0.1 0.00016 21.4 0.1 2.0 2 0 0 2 2 2 1 UBA-like domain PUL PF08324.11 EFC50043.1 - 4.5e-05 22.8 0.7 0.00013 21.3 0.7 1.8 1 0 0 1 1 1 1 PUL domain DUF1870 PF08965.10 EFC50043.1 - 0.057 13.4 0.4 0.52 10.4 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) RNB PF00773.19 EFC50044.1 - 4.8e-58 197.0 0.1 4.8e-58 197.0 0.1 2.3 2 0 0 2 2 2 1 RNB domain NifW PF03206.14 EFC50044.1 - 0.028 14.9 1.0 0.13 12.8 0.3 2.5 2 0 0 2 2 2 0 Nitrogen fixation protein NifW Orthopox_35kD PF02250.15 EFC50044.1 - 0.049 13.3 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 35kD major secreted virus protein AAA PF00004.29 EFC50045.1 - 4.6e-07 30.3 0.2 1.7e-06 28.5 0.0 2.0 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EFC50045.1 - 5.5e-06 25.9 0.4 0.0034 16.8 0.0 2.3 2 0 0 2 2 2 2 KaiC AAA_18 PF13238.6 EFC50045.1 - 6.1e-06 26.8 0.1 2e-05 25.1 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 EFC50045.1 - 7.2e-06 26.5 0.1 2.9e-05 24.5 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 EFC50045.1 - 7.3e-06 26.0 2.7 0.1 12.5 0.0 2.9 3 0 0 3 3 3 2 NTPase AAA_24 PF13479.6 EFC50045.1 - 9.2e-06 25.5 0.1 2.3e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 EFC50045.1 - 3.9e-05 23.9 0.4 0.00027 21.2 0.4 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 EFC50045.1 - 4.6e-05 23.4 0.2 0.00022 21.2 0.2 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) T2SSE PF00437.20 EFC50045.1 - 5.9e-05 22.3 0.5 8.3e-05 21.8 0.5 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 EFC50045.1 - 7.7e-05 22.3 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 EFC50045.1 - 0.00011 21.5 0.0 0.00025 20.4 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 EFC50045.1 - 0.00018 21.1 0.8 0.011 15.4 0.8 2.4 1 1 0 1 1 1 1 AAA domain GvpD PF07088.11 EFC50045.1 - 0.00019 20.2 0.1 0.00028 19.7 0.1 1.2 1 0 0 1 1 1 1 GvpD gas vesicle protein AAA_30 PF13604.6 EFC50045.1 - 0.00028 20.7 0.2 0.00097 18.9 0.2 1.8 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 EFC50045.1 - 0.00062 19.6 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase ABC_tran PF00005.27 EFC50045.1 - 0.00076 20.0 1.0 0.023 15.2 0.1 2.7 2 1 0 3 3 3 1 ABC transporter FtsK_SpoIIIE PF01580.18 EFC50045.1 - 0.0008 18.8 0.1 0.0018 17.7 0.1 1.7 1 1 0 1 1 1 1 FtsK/SpoIIIE family AAA_14 PF13173.6 EFC50045.1 - 0.0014 18.7 0.0 0.0043 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 EFC50045.1 - 0.0015 18.7 0.4 0.0078 16.4 0.5 2.0 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 EFC50045.1 - 0.0019 18.1 0.1 0.0047 16.9 0.0 1.6 2 0 0 2 2 1 1 NACHT domain TsaE PF02367.17 EFC50045.1 - 0.0021 18.1 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TrwB_AAD_bind PF10412.9 EFC50045.1 - 0.0034 16.3 0.4 0.0077 15.2 0.0 1.6 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_19 PF13245.6 EFC50045.1 - 0.0039 17.5 0.2 0.023 15.0 0.0 2.0 1 1 1 2 2 2 1 AAA domain TniB PF05621.11 EFC50045.1 - 0.0043 16.5 0.7 0.094 12.1 0.6 2.5 1 1 0 1 1 1 1 Bacterial TniB protein KTI12 PF08433.10 EFC50045.1 - 0.0055 16.2 0.0 0.0096 15.4 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ATP_bind_1 PF03029.17 EFC50045.1 - 0.0057 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 EFC50045.1 - 0.008 16.6 0.1 0.048 14.1 0.0 2.4 2 1 0 2 2 2 1 RNA helicase CbiA PF01656.23 EFC50045.1 - 0.0097 16.0 0.1 0.036 14.1 0.1 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_11 PF13086.6 EFC50045.1 - 0.012 15.4 0.1 0.086 12.6 0.0 1.9 1 1 1 2 2 2 0 AAA domain IstB_IS21 PF01695.17 EFC50045.1 - 0.015 15.0 0.1 0.75 9.5 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Pox_A32 PF04665.12 EFC50045.1 - 0.018 14.5 0.1 0.046 13.2 0.0 1.7 2 0 0 2 2 2 0 Poxvirus A32 protein G-alpha PF00503.20 EFC50045.1 - 0.019 14.2 0.0 0.035 13.3 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit AAA_2 PF07724.14 EFC50045.1 - 0.023 14.8 0.7 0.29 11.2 0.1 2.6 2 1 1 3 3 3 0 AAA domain (Cdc48 subfamily) SRP54 PF00448.22 EFC50045.1 - 0.032 13.9 0.1 0.094 12.3 0.1 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain cobW PF02492.19 EFC50045.1 - 0.033 13.8 0.1 0.09 12.4 0.1 1.9 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 EFC50045.1 - 0.036 13.8 0.1 0.079 12.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 EFC50045.1 - 0.055 13.7 0.2 0.2 11.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 EFC50045.1 - 0.059 12.6 0.2 0.31 10.2 0.0 1.9 2 0 0 2 2 2 0 KAP family P-loop domain Rad17 PF03215.15 EFC50045.1 - 0.13 12.1 0.3 0.91 9.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain Roc PF08477.13 EFC50045.1 - 0.14 12.3 0.1 0.44 10.8 0.0 1.9 2 1 0 2 2 1 0 Ras of Complex, Roc, domain of DAPkinase BSD PF03909.17 EFC50046.1 - 1.6e-12 47.3 0.4 3.5e-12 46.1 0.4 1.6 1 0 0 1 1 1 1 BSD domain TraG-D_C PF12696.7 EFC50046.1 - 0.025 14.6 1.9 2.9 7.9 0.0 2.6 3 0 0 3 3 3 0 TraM recognition site of TraD and TraG Guanylate_cyc PF00211.20 EFC50047.1 - 8.3e-42 142.9 0.2 1.1e-41 142.5 0.2 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Glyco_hydro_75 PF07335.11 EFC50047.1 - 0.0031 17.8 0.1 0.0041 17.4 0.1 1.3 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 PAS_9 PF13426.7 EFC50048.1 - 8e-15 55.0 0.1 3.4e-14 52.9 0.1 2.2 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC50048.1 - 0.00028 20.9 0.0 0.00078 19.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC50048.1 - 0.0062 16.5 0.0 0.02 14.9 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 EFC50048.1 - 0.2 11.9 0.0 0.49 10.7 0.0 1.6 2 0 0 2 2 2 0 PAS fold HNOBA PF07701.14 EFC50048.1 - 0.25 10.8 5.6 0.97 8.8 5.5 2.0 1 1 0 1 1 1 0 Heme NO binding associated Neogenin_C PF06583.12 EFC50049.1 - 0.089 12.6 1.4 0.13 12.1 1.4 1.2 1 0 0 1 1 1 0 Neogenin C-terminus Pkinase PF00069.25 EFC50050.1 - 1.5e-73 247.4 0.0 1.8e-73 247.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50050.1 - 1.2e-32 113.3 0.0 1.6e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC50050.1 - 0.00077 18.5 0.1 0.003 16.6 0.1 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC50050.1 - 0.00089 18.7 0.2 0.0021 17.4 0.2 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC50050.1 - 0.02 14.8 0.0 0.047 13.6 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 EFC50050.1 - 0.045 13.3 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 EFC50050.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Tmemb_9 PF05434.11 EFC50051.1 - 0.021 14.7 0.2 0.039 13.9 0.2 1.4 1 0 0 1 1 1 0 TMEM9 SIT PF15330.6 EFC50051.1 - 0.03 14.7 0.1 0.56 10.7 0.0 2.4 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Consortin_C PF15281.6 EFC50051.1 - 0.034 14.2 0.1 0.081 12.9 0.1 1.7 1 0 0 1 1 1 0 Consortin C-terminus ABC_membrane_3 PF13748.6 EFC50051.1 - 0.055 12.7 0.1 0.63 9.2 0.1 2.0 2 0 0 2 2 2 0 ABC transporter transmembrane region DUF4179 PF13786.6 EFC50051.1 - 0.088 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) Aldo_ket_red PF00248.21 EFC50052.1 - 1.4e-81 274.0 0.0 1.5e-81 273.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AT_hook PF02178.19 EFC50053.1 - 3.7 7.7 8.0 10 6.4 8.0 1.8 1 0 0 1 1 1 0 AT hook motif UQ_con PF00179.26 EFC50054.1 - 4.7e-17 61.9 0.0 5.5e-17 61.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 EFC50054.1 - 0.013 15.8 0.2 0.018 15.3 0.2 1.4 1 1 0 1 1 1 0 RWD domain NABP PF07990.12 EFC50056.1 - 0.0067 16.0 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 Nucleic acid binding protein NABP ATP13 PF12921.7 EFC50056.1 - 0.07 13.0 0.9 0.35 10.7 0.1 2.6 3 0 0 3 3 3 0 Mitochondrial ATPase expression DUF2613 PF11021.8 EFC50056.1 - 0.87 9.7 2.9 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Ctr PF04145.15 EFC50057.1 - 2.1e-19 70.6 7.3 6.3e-19 69.1 7.3 1.7 1 1 0 1 1 1 1 Ctr copper transporter family F-box-like PF12937.7 EFC50058.1 - 0.0039 17.1 0.0 0.015 15.2 0.0 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC50058.1 - 0.054 13.4 0.6 0.16 11.9 0.0 2.1 3 0 0 3 3 3 0 F-box domain TSNAXIP1_N PF15739.5 EFC50059.1 - 0.00015 22.1 11.1 0.00062 20.1 10.2 2.5 1 1 0 1 1 1 1 Translin-associated factor X-interacting N-terminus SdrD_B PF17210.3 EFC50060.1 - 0.11 12.8 0.1 23 5.3 0.1 2.9 3 0 0 3 3 3 0 SdrD B-like domain Mito_carr PF00153.27 EFC50061.1 - 1.5e-27 95.4 0.0 1.3e-09 37.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein G6B PF15096.6 EFC50062.1 - 0.045 13.5 0.5 0.074 12.8 0.5 1.3 1 0 0 1 1 1 0 G6B family Ureide_permease PF07168.11 EFC50062.1 - 0.14 10.9 1.5 0.2 10.3 1.5 1.2 1 0 0 1 1 1 0 Ureide permease COPR5 PF15340.6 EFC50062.1 - 0.23 12.1 1.7 0.49 11.0 1.7 1.5 1 0 0 1 1 1 0 Cooperator of PRMT5 family Coilin_N PF15862.5 EFC50062.1 - 0.91 9.3 9.1 2 8.2 9.1 1.6 1 0 0 1 1 1 0 Coilin N-terminus Hamartin PF04388.12 EFC50062.1 - 1.2 7.7 22.6 1.6 7.3 22.6 1.1 1 0 0 1 1 1 0 Hamartin protein Rab5ip PF07019.12 EFC50063.1 - 4.2e-19 68.9 13.6 5e-19 68.7 13.6 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF4006 PF13179.6 EFC50063.1 - 5.5 7.0 5.6 13 5.8 5.6 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF4006) Sec34 PF04136.15 EFC50064.1 - 0.0015 18.4 13.8 0.062 13.2 4.8 2.5 2 1 0 2 2 2 2 Sec34-like family Leu_zip PF15294.6 EFC50064.1 - 0.037 13.5 19.5 0.19 11.2 19.0 2.0 1 1 1 2 2 2 0 Leucine zipper PIN_12 PF16289.5 EFC50064.1 - 0.057 13.9 11.7 0.035 14.6 9.8 1.5 1 1 0 1 1 1 0 PIN domain YtxH PF12732.7 EFC50064.1 - 0.12 12.9 1.4 8.3 7.0 0.0 2.9 1 1 1 2 2 2 0 YtxH-like protein DASH_Dam1 PF08653.10 EFC50064.1 - 0.28 11.0 2.7 2.4 8.0 0.2 3.5 3 1 1 4 4 4 0 DASH complex subunit Dam1 Med9 PF07544.13 EFC50064.1 - 0.49 10.5 16.4 19 5.4 11.1 3.6 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF501 PF04417.12 EFC50064.1 - 0.52 10.1 4.8 0.98 9.2 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF501) DUF1664 PF07889.12 EFC50064.1 - 1.7 8.7 11.2 2.6 8.1 2.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) PhoQ_Sensor PF08918.10 EFC50064.1 - 1.9 8.3 8.5 7.9 6.3 0.3 2.5 1 1 1 2 2 2 0 PhoQ Sensor NPV_P10 PF05531.12 EFC50064.1 - 2.1 8.9 11.0 0.51 10.8 3.5 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 EFC50064.1 - 4.3 8.0 13.9 2.8 8.6 2.0 3.0 1 1 1 2 2 2 0 Initiation control protein YabA Occludin_ELL PF07303.13 EFC50064.1 - 5.9 7.7 13.4 4 8.2 4.6 2.6 1 1 1 2 2 2 0 Occludin homology domain Pkinase PF00069.25 EFC50066.1 - 8.7e-63 212.1 0.3 2.7e-62 210.6 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50066.1 - 1.8e-50 171.7 0.0 3.4e-50 170.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC50066.1 - 0.0021 16.9 4.1 0.0045 15.8 0.0 2.5 2 0 0 2 2 2 1 Fungal protein kinase NRBF2 PF08961.10 EFC50066.1 - 0.0028 17.3 4.8 0.0028 17.3 4.8 2.2 1 1 1 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator bZIP_2 PF07716.15 EFC50066.1 - 0.003 17.6 6.6 0.0095 16.0 6.6 1.9 1 0 0 1 1 1 1 Basic region leucine zipper Kdo PF06293.14 EFC50066.1 - 0.021 14.2 0.0 0.083 12.2 0.0 1.9 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1902 PF08972.11 EFC50066.1 - 0.19 11.8 0.5 0.69 9.9 0.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) bZIP_1 PF00170.21 EFC50066.1 - 0.36 11.0 9.0 0.045 13.8 4.0 2.1 2 0 0 2 2 2 0 bZIP transcription factor Cep57_CLD_2 PF14197.6 EFC50066.1 - 0.89 9.7 11.0 2.6 8.2 11.0 1.8 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 TSC22 PF01166.18 EFC50066.1 - 2.4 8.5 8.7 0.2 12.0 3.5 2.0 2 0 0 2 2 1 0 TSC-22/dip/bun family PikAIV_N PF18605.1 EFC50066.1 - 6.6 6.4 12.1 2.4 7.8 8.8 2.0 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain adh_short PF00106.25 EFC50067.1 - 6.9e-20 71.3 0.0 6.1e-17 61.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 EFC50067.1 - 1.5e-10 41.0 0.0 1.4e-07 31.3 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 EFC50067.1 - 5.9e-06 25.9 0.1 1e-05 25.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 EFC50067.1 - 0.013 15.3 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CLCA PF08434.11 EFC50067.1 - 0.052 12.9 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Calcium-activated chloride channel N terminal DUF1776 PF08643.10 EFC50067.1 - 0.081 12.3 0.0 1.2 8.4 0.0 2.4 3 0 0 3 3 3 0 Fungal family of unknown function (DUF1776) WD40 PF00400.32 EFC50068.1 - 2.6e-20 72.4 5.7 1.2e-10 41.8 0.1 5.5 4 1 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50068.1 - 5.4e-12 45.8 1.6 0.00012 22.3 0.1 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC50068.1 - 2.4e-09 36.6 0.1 9.2e-05 21.6 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 EFC50068.1 - 0.0044 16.4 0.2 0.16 11.3 0.0 2.4 2 0 0 2 2 2 1 WD40-like domain bZIP_1 PF00170.21 EFC50068.1 - 0.26 11.4 2.8 0.58 10.3 2.8 1.6 1 0 0 1 1 1 0 bZIP transcription factor eRF1_1 PF03463.15 EFC50069.1 - 2.2e-46 157.0 0.4 4.3e-46 156.1 0.4 1.5 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 EFC50069.1 - 2.1e-25 89.4 0.0 7e-25 87.7 0.0 1.9 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 EFC50069.1 - 1e-22 80.9 1.5 1e-22 80.9 1.5 1.7 2 0 0 2 2 2 1 eRF1 domain 2 P53 PF00870.18 EFC50069.1 - 0.04 13.7 1.3 0.068 12.9 1.3 1.3 1 0 0 1 1 1 0 P53 DNA-binding domain PDEase_I PF00233.19 EFC50070.1 - 4.6e-64 216.4 0.7 9.4e-64 215.4 0.7 1.5 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Complex1_LYR PF05347.15 EFC50072.1 - 3e-07 30.4 0.2 7.5e-07 29.1 0.0 1.8 1 1 1 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 EFC50072.1 - 7.1e-05 23.3 0.5 9.2e-05 23.0 0.5 1.2 1 0 0 1 1 1 1 Complex1_LYR-like DUF2121 PF09894.9 EFC50072.1 - 0.012 15.1 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2121) HSL_N PF06350.12 EFC50072.1 - 0.04 12.9 0.0 0.043 12.8 0.0 1.1 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus Complex1_LYR_2 PF13233.6 EFC50072.1 - 0.092 13.5 2.6 0.22 12.3 2.6 1.8 1 1 0 1 1 1 0 Complex1_LYR-like Metallophos PF00149.28 EFC50073.1 - 2.2e-12 47.9 5.1 4.5e-12 46.9 5.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 EFC50073.1 - 7.4e-08 32.8 0.6 0.0012 19.0 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain DCP2 PF05026.13 EFC50074.1 - 3.9e-29 100.8 5.4 3.9e-29 100.8 5.4 1.6 2 0 0 2 2 2 1 Dcp2, box A domain NUDIX PF00293.28 EFC50074.1 - 1.7e-12 47.5 0.2 5.1e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain NUDIX_2 PF13869.6 EFC50074.1 - 0.091 12.3 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 Nucleotide hydrolase DUF547 PF04784.14 EFC50076.1 - 2.9e-21 75.8 0.7 8.3e-21 74.3 0.7 1.9 1 0 0 1 1 1 1 Protein of unknown function, DUF547 RGS PF00615.19 EFC50076.1 - 3.3e-14 53.2 4.6 3.3e-14 53.2 4.6 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Peptidase_S8 PF00082.22 EFC50077.1 - 1.1e-36 126.7 3.6 1.5e-36 126.2 3.6 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 EFC50077.1 - 5e-13 48.9 0.0 8.9e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Proprotein convertase P-domain 6PF2K PF01591.18 EFC50077.1 - 0.18 11.1 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase zf-UDP PF14569.6 EFC50078.1 - 0.0071 16.4 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding RING-finger Phage_holin_1 PF04531.13 EFC50078.1 - 0.0096 16.4 1.2 0.022 15.3 1.2 1.5 1 0 0 1 1 1 1 Bacteriophage holin DEAD PF00270.29 EFC50079.1 - 1.7e-27 96.3 2.1 3.9e-27 95.1 2.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50079.1 - 5.4e-15 55.7 0.1 2.7e-14 53.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 EFC50079.1 - 0.0012 19.2 0.0 0.0034 17.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain HTH_25 PF13413.6 EFC50079.1 - 0.086 12.7 0.3 5 7.1 0.4 2.8 2 0 0 2 2 2 0 Helix-turn-helix domain AAA_22 PF13401.6 EFC50079.1 - 0.95 9.7 5.5 0.23 11.7 0.2 2.7 3 0 0 3 3 3 0 AAA domain EGF_2 PF07974.13 EFC50080.1 - 0.0012 19.2 29.2 0.1 12.9 9.5 2.6 2 0 0 2 2 2 2 EGF-like domain TraI PF07057.11 EFC50080.1 - 0.14 12.3 0.0 13 5.9 0.0 3.4 4 0 0 4 4 4 0 DNA helicase TraI TNFR_c6 PF00020.18 EFC50080.1 - 2.5 8.6 25.7 15 6.1 1.1 6.8 6 0 0 6 6 6 0 TNFR/NGFR cysteine-rich region RGS PF00615.19 EFC50081.1 - 0.0051 17.1 2.7 0.0068 16.7 0.5 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain GCFC PF07842.12 EFC50082.1 - 4.9e-39 134.6 10.5 4.9e-39 134.6 10.5 1.8 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 EFC50082.1 - 9e-11 41.5 0.1 2e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 G-patch domain PDEase_I_N PF08499.12 EFC50082.1 - 0.08 12.8 1.3 1.7 8.5 0.2 3.5 4 0 0 4 4 4 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal G-patch_2 PF12656.7 EFC50082.1 - 1.1 9.5 3.6 0.52 10.4 0.1 2.4 2 0 0 2 2 2 0 G-patch domain PCMT PF01135.19 EFC50083.1 - 5.8e-11 42.5 0.0 4.1e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SPRY PF00622.28 EFC50083.1 - 2.6e-06 27.5 3.0 7.7e-06 26.0 1.4 2.5 1 1 1 2 2 2 1 SPRY domain Ubie_methyltran PF01209.18 EFC50083.1 - 0.0011 18.3 0.0 0.0023 17.3 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 EFC50083.1 - 0.0014 18.5 0.6 0.0077 16.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.13 EFC50083.1 - 0.0021 17.6 0.0 0.0062 16.1 0.0 1.8 1 0 0 1 1 1 1 Histone methylation protein DOT1 PrmA PF06325.13 EFC50083.1 - 0.011 15.1 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 EFC50083.1 - 0.013 16.2 0.0 0.079 13.7 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 EFC50083.1 - 0.099 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Sel1 PF08238.12 EFC50084.1 - 2.1e-27 95.0 5.5 1.1e-06 29.1 0.1 4.2 4 0 0 4 4 4 4 Sel1 repeat NPL4 PF05021.15 EFC50085.1 - 5.9e-21 75.1 0.1 7.2e-06 25.6 0.0 3.4 1 1 2 3 3 3 3 NPL4 family UN_NPL4 PF11543.8 EFC50085.1 - 2.1e-08 34.5 0.4 7.8e-08 32.7 0.1 2.2 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 ubiquitin PF00240.23 EFC50085.1 - 0.0012 18.6 0.2 0.0038 16.9 0.2 2.0 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC50085.1 - 0.087 12.7 1.2 0.45 10.4 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like PaREP1 PF05942.11 EFC50086.1 - 0.037 13.9 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 Archaeal PaREP1/PaREP8 family Pkinase PF00069.25 EFC50087.1 - 1.7e-25 89.9 0.1 2.2e-25 89.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50087.1 - 6.1e-17 61.8 0.1 7.7e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC50087.1 - 1.2e-10 40.8 0.1 1.6e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC50087.1 - 5.2e-05 23.3 0.0 0.005 16.8 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 EFC50087.1 - 0.0046 16.0 0.1 0.0064 15.5 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 EFC50087.1 - 0.0058 16.0 0.1 1.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_Tyr PF07714.17 EFC50088.1 - 1.7e-59 201.2 0.1 3e-53 180.7 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 EFC50088.1 - 2.2e-55 187.9 0.0 3.1e-55 187.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 EFC50088.1 - 1e-05 24.6 0.0 1.4e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 EFC50088.1 - 0.00038 20.5 0.0 0.002 18.1 0.0 1.8 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC50088.1 - 0.0011 18.0 0.0 0.003 16.6 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 EFC50088.1 - 0.0064 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 EFC50088.1 - 0.013 14.8 0.0 0.028 13.7 0.0 1.5 1 1 0 1 1 1 0 Kinase-like FTA2 PF13095.6 EFC50088.1 - 0.16 11.6 0.0 13 5.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Methyltransf_16 PF10294.9 EFC50089.1 - 1.9e-18 66.8 0.0 2.3e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 EFC50089.1 - 0.032 13.6 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) LRR_6 PF13516.6 EFC50090.1 - 0.046 13.8 40.5 0.18 11.9 0.3 7.7 7 0 0 7 7 7 0 Leucine Rich repeat ubiquitin PF00240.23 EFC50092.1 - 1.8e-17 62.9 0.1 2.2e-17 62.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC50092.1 - 0.00026 20.8 0.4 0.00039 20.2 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 EFC50092.1 - 0.0026 17.7 0.0 0.0029 17.5 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_4 PF18036.1 EFC50092.1 - 0.0066 16.5 0.2 3.2 7.8 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-like domain UN_NPL4 PF11543.8 EFC50092.1 - 0.038 14.5 0.0 0.055 13.9 0.0 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Glyco_hydro_15 PF00723.21 EFC50092.1 - 0.063 12.1 0.1 0.073 11.8 0.1 1.0 1 0 0 1 1 1 0 Glycosyl hydrolases family 15 Renin_r PF07850.14 EFC50093.1 - 0.0052 17.4 0.1 0.0052 17.4 0.1 3.8 5 1 1 6 6 6 1 Renin receptor-like protein Anoctamin PF04547.12 EFC50094.1 - 1.8e-09 37.0 21.8 5.4e-09 35.4 21.8 1.8 1 1 0 1 1 1 1 Calcium-activated chloride channel TMC PF07810.13 EFC50094.1 - 6.1e-08 33.2 0.3 6.1e-08 33.2 0.3 3.3 2 2 0 3 3 3 1 TMC domain DEAD PF00270.29 EFC50095.1 - 6.2e-32 110.8 0.0 1.6e-31 109.4 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50095.1 - 1e-24 87.0 0.2 3.4e-22 78.9 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Sugar_tr PF00083.24 EFC50095.1 - 1.1e-15 57.5 9.2 3.5e-15 55.8 9.2 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter ResIII PF04851.15 EFC50095.1 - 5.2e-10 39.6 1.5 8.9e-10 38.8 0.1 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MFS_1 PF07690.16 EFC50095.1 - 0.00026 20.1 2.5 0.00026 20.1 2.5 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily AAA_19 PF13245.6 EFC50095.1 - 0.0018 18.6 0.2 0.33 11.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain 7TM-7TMR_HD PF07698.11 EFC50095.1 - 2.3 7.9 10.7 0.56 9.9 4.7 2.2 2 0 0 2 2 2 0 7TM receptor with intracellular HD hydrolase DUF3446 PF11928.8 EFC50095.1 - 2.9 8.3 14.6 6.8 7.1 7.4 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain LRR_6 PF13516.6 EFC50096.1 - 6.3e-27 91.3 28.1 2.9e-05 23.8 0.7 9.3 9 0 0 9 9 9 7 Leucine Rich repeat LRR_1 PF00560.33 EFC50096.1 - 2e-09 36.7 30.3 0.86 10.4 0.3 9.3 10 1 0 10 10 10 4 Leucine Rich Repeat LRR_4 PF12799.7 EFC50096.1 - 1e-08 35.3 32.5 0.065 13.7 4.5 7.0 1 1 5 7 7 7 6 Leucine Rich repeats (2 copies) F-box-like PF12937.7 EFC50096.1 - 3.1e-06 27.0 3.2 3.2e-06 26.9 0.5 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 EFC50096.1 - 0.0061 16.4 5.4 0.008 16.0 0.1 2.9 3 0 0 3 3 3 1 F-box domain gag_pre-integrs PF13976.6 EFC50096.1 - 0.21 11.4 3.0 2.3 8.1 0.0 3.2 3 0 0 3 3 3 0 GAG-pre-integrase domain LRR_8 PF13855.6 EFC50096.1 - 0.72 9.7 30.0 3.8 7.3 1.2 6.6 4 4 1 5 5 5 0 Leucine rich repeat LRR_2 PF07723.13 EFC50096.1 - 7.7 7.4 8.3 2.4 9.0 0.1 4.0 5 0 0 5 5 5 0 Leucine Rich Repeat Ank_2 PF12796.7 EFC50097.1 - 9.2e-12 45.4 0.1 1.4e-11 44.8 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC50097.1 - 1.8e-10 41.1 0.4 7.5e-07 29.6 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC50097.1 - 9.1e-09 35.4 0.7 0.0074 16.6 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 EFC50097.1 - 2.3e-08 34.1 0.0 0.02 15.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 EFC50097.1 - 7.1e-08 32.1 0.1 0.076 13.6 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Prok_Ub PF14454.6 EFC50097.1 - 0.11 12.2 0.0 0.29 10.8 0.0 1.7 1 0 0 1 1 1 0 Prokaryotic Ubiquitin RNase_T PF00929.24 EFC50098.1 - 5.7e-24 85.5 0.2 6.7e-24 85.3 0.2 1.1 1 0 0 1 1 1 1 Exonuclease CHS5_N PF16892.5 EFC50098.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Chitin biosynthesis protein CHS5 N-terminus Pkinase PF00069.25 EFC50099.1 - 9.5e-38 130.1 0.4 1e-37 129.9 0.4 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50099.1 - 2e-35 122.3 0.1 2.2e-35 122.2 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 EFC50099.1 - 0.001 19.1 0.0 0.0031 17.5 0.0 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC50099.1 - 0.0082 15.1 0.1 0.028 13.4 0.1 1.9 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 EFC50099.1 - 0.053 13.1 0.2 0.095 12.3 0.2 1.4 1 1 0 1 1 1 0 RIO1 family DUF4405 PF14358.6 EFC50100.1 - 0.00015 22.3 5.2 0.051 14.1 0.0 3.0 3 1 0 3 3 3 2 Domain of unknown function (DUF4405) Ni_hydr_CYTB PF01292.20 EFC50100.1 - 0.0029 17.2 3.4 0.17 11.5 1.9 2.3 2 0 0 2 2 2 2 Prokaryotic cytochrome b561 ETRAMP PF09716.10 EFC50100.1 - 0.089 12.9 0.4 0.25 11.4 0.4 1.7 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Dymeclin PF09742.9 EFC50101.1 - 5.8e-74 249.7 33.0 6.3e-71 239.6 22.4 3.0 3 0 0 3 3 3 3 Dyggve-Melchior-Clausen syndrome protein Vmethyltransf_C PF08456.10 EFC50102.1 - 0.016 14.8 1.0 0.027 14.0 1.0 1.3 1 0 0 1 1 1 0 Viral methyltransferase C-terminal RIC3 PF15361.6 EFC50103.1 - 1.5 9.2 5.5 0.68 10.3 0.6 2.6 3 0 0 3 3 3 0 Resistance to inhibitors of cholinesterase homologue 3 Gypsy PF07253.11 EFC50104.1 - 0.38 9.2 5.7 0.64 8.5 5.7 1.3 1 0 0 1 1 1 0 Gypsy protein WAP PF00095.21 EFC50104.1 - 1.4 9.4 0.0 1.4 9.4 0.0 5.9 4 3 2 6 6 6 0 WAP-type (Whey Acidic Protein) 'four-disulfide core' WD40 PF00400.32 EFC50105.1 - 5.8e-09 36.4 1.1 0.00036 21.3 0.2 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat GLYCAM-1 PF05242.11 EFC50105.1 - 0.0025 17.9 1.9 0.01 16.0 1.9 2.0 1 0 0 1 1 1 1 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Pkinase PF00069.25 EFC50106.1 - 8.2e-31 107.3 0.3 1.3e-30 106.7 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50106.1 - 5.2e-25 88.2 0.0 9.2e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RCC1_2 PF13540.6 EFC50106.1 - 2.7e-22 78.0 8.7 4.9e-07 29.4 0.2 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 EFC50106.1 - 9.8e-18 64.5 0.8 6.1e-06 26.8 0.0 4.1 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Kdo PF06293.14 EFC50106.1 - 0.052 12.9 0.1 0.09 12.1 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cytochrom_C PF00034.21 EFC50108.1 - 3.5e-12 47.3 0.3 5.4e-12 46.7 0.3 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 EFC50108.1 - 2.3e-07 31.0 3.0 1.7e-06 28.3 3.0 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 EFC50108.1 - 0.00089 19.0 0.5 0.0084 15.8 0.1 2.3 2 1 0 2 2 2 1 Cytochrome c-550 domain Guanylate_cyc PF00211.20 EFC50110.1 - 2.8e-57 193.3 0.1 6.8e-57 192.0 0.1 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC50110.1 - 3e-13 49.9 1.1 5e-12 46.0 0.2 2.8 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC50110.1 - 1.5e-08 34.6 0.0 3.7e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC50110.1 - 0.00011 22.1 0.0 0.0014 18.6 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 EFC50110.1 - 0.026 14.8 0.0 0.081 13.2 0.0 1.8 2 0 0 2 2 2 0 PAS fold PHA_synth_III_E PF09712.10 EFC50110.1 - 0.065 12.3 1.0 0.35 9.9 0.6 2.3 2 0 0 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) DUF382 PF04037.13 EFC50111.1 - 3.1e-57 192.2 3.1 1.7e-56 189.8 3.1 2.4 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 EFC50111.1 - 4.3e-18 64.9 2.9 8e-18 64.1 2.9 1.5 1 0 0 1 1 1 1 PSP YfhO PF09586.10 EFC50111.1 - 2 6.6 7.7 3.4 5.8 7.7 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SIT PF15330.6 EFC50113.1 - 0.0052 17.2 0.4 0.012 16.0 0.1 1.7 1 1 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT bZIP_2 PF07716.15 EFC50113.1 - 0.068 13.3 2.4 0.17 12.0 2.4 1.6 1 0 0 1 1 1 0 Basic region leucine zipper DUF3332 PF11810.8 EFC50113.1 - 0.23 11.1 0.1 13 5.4 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3332) TAFII28 PF04719.14 EFC50114.1 - 3.4e-25 88.0 0.0 5.7e-25 87.2 0.0 1.3 1 0 0 1 1 1 1 hTAFII28-like protein conserved region SDF PF00375.18 EFC50116.1 - 3.4e-109 365.4 41.2 2e-99 333.2 30.1 2.8 2 1 0 2 2 2 2 Sodium:dicarboxylate symporter family Sigma_reg_N PF13800.6 EFC50116.1 - 0.3 11.4 0.1 0.3 11.4 0.1 4.1 4 0 0 4 4 4 0 Sigma factor regulator N-terminal Sec34 PF04136.15 EFC50117.1 - 8.5e-32 110.1 9.9 8.5e-32 110.1 9.9 4.6 4 1 0 4 4 4 1 Sec34-like family NACHT_N PF17100.5 EFC50117.1 - 0.016 15.0 0.5 0.065 13.1 0.5 2.1 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase DUF1804 PF08822.11 EFC50117.1 - 0.57 10.1 4.9 0.29 11.1 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1804) SQHop_cyclase_C PF13243.6 EFC50118.1 - 6.6e-49 166.7 0.1 8.9e-42 143.3 0.1 3.0 2 2 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 EFC50118.1 - 3.7e-39 134.6 0.0 2.3e-36 125.4 0.0 3.2 2 1 1 3 3 3 1 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 EFC50118.1 - 2e-27 94.6 13.5 1.6e-09 37.3 0.0 5.2 6 0 0 6 6 6 4 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 EFC50118.1 - 0.0036 16.7 0.4 6.4 6.0 0.0 3.4 3 0 0 3 3 3 2 Pectic acid lyase Cyt-b5 PF00173.28 EFC50120.1 - 1.4e-12 47.5 0.3 2.5e-12 46.7 0.3 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF3687 PF12459.8 EFC50120.1 - 0.0022 17.5 3.7 0.0048 16.4 2.2 2.3 1 1 1 2 2 2 1 D-Ala-teichoic acid biosynthesis protein DNMT1-RFD PF12047.8 EFC50120.1 - 0.027 14.5 0.2 0.054 13.5 0.2 1.4 1 0 0 1 1 1 0 Cytosine specific DNA methyltransferase replication foci domain Sp38 PF07354.12 EFC50121.1 - 0.088 12.2 1.2 0.17 11.3 1.2 1.5 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Macoilin PF09726.9 EFC50121.1 - 9.8 4.6 35.3 15 4.0 35.3 1.2 1 0 0 1 1 1 0 Macoilin family ANAPC4_WD40 PF12894.7 EFC50122.1 - 4.2e-05 23.8 0.5 0.33 11.3 0.0 4.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC50122.1 - 0.00049 20.9 3.0 0.013 16.4 0.1 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat KRAB PF01352.27 EFC50122.1 - 1 9.1 2.9 10 5.9 0.2 2.6 2 0 0 2 2 2 0 KRAB box LIN37 PF15306.6 EFC50124.1 - 0.0062 16.8 1.6 0.0062 16.8 1.6 1.8 2 1 0 2 2 2 1 LIN37 UCH PF00443.29 EFC50125.1 - 4.1e-78 262.4 0.6 4.1e-78 262.4 0.6 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 EFC50125.1 - 3.5e-16 59.6 0.3 3.5e-16 59.6 0.3 2.7 3 0 0 3 3 3 1 DUSP domain UCH_1 PF13423.6 EFC50125.1 - 1.5e-13 51.0 12.6 1.1e-08 35.0 0.5 3.7 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 EFC50125.1 - 0.0024 17.2 0.1 0.027 13.8 0.0 2.3 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 Ubiquitin_3 PF14836.6 EFC50125.1 - 0.012 15.6 0.0 0.036 14.0 0.0 1.9 1 0 0 1 1 1 0 Ubiquitin-like domain PCI PF01399.27 EFC50126.1 - 2.8e-17 63.1 0.6 6.9e-17 61.9 0.1 1.9 2 0 0 2 2 2 1 PCI domain Cystatin PF00031.21 EFC50127.1 - 1.3e-07 31.7 0.3 1.4e-07 31.7 0.3 1.1 1 0 0 1 1 1 1 Cystatin domain SQAPI PF16845.5 EFC50127.1 - 0.0089 16.3 0.2 0.011 16.0 0.2 1.4 1 0 0 1 1 1 1 Aspartic acid proteinase inhibitor MFS_1 PF07690.16 EFC50129.1 - 2.8e-19 69.3 75.5 4e-17 62.2 41.4 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_3 PF05977.13 EFC50129.1 - 1.5e-12 46.7 13.2 4.9e-12 45.0 4.3 2.1 2 0 0 2 2 2 2 Transmembrane secretion effector MFS_1_like PF12832.7 EFC50129.1 - 0.00099 18.1 27.5 0.02 13.8 20.2 2.7 2 1 0 2 2 2 2 MFS_1 like family TMPIT PF07851.13 EFC50129.1 - 0.48 9.6 2.6 0.87 8.8 0.1 2.4 2 0 0 2 2 2 0 TMPIT-like protein PBP1_TM PF14812.6 EFC50130.1 - 0.13 12.6 14.7 0.12 12.8 13.1 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 EFC50130.1 - 0.17 11.2 15.1 0.19 11.0 15.1 1.0 1 0 0 1 1 1 0 NOA36 protein Ycf1 PF05758.12 EFC50130.1 - 2.5 5.9 10.8 2.7 5.7 10.8 1.1 1 0 0 1 1 1 0 Ycf1 CSG2 PF16965.5 EFC50130.1 - 4.8 6.0 5.9 5.3 5.9 5.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator ABC_membrane PF00664.23 EFC50131.1 - 6.1e-50 170.4 23.7 8.8e-50 169.9 23.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 EFC50131.1 - 9.3e-35 120.1 0.0 2.2e-34 118.9 0.0 1.7 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 EFC50131.1 - 1.2e-06 28.1 1.2 0.00041 19.8 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 EFC50131.1 - 0.00068 20.1 0.0 0.002 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 EFC50131.1 - 0.00072 19.2 0.1 0.0018 18.0 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC50131.1 - 0.0018 18.1 0.0 0.0043 16.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 EFC50131.1 - 0.002 17.9 0.1 0.0043 16.8 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 EFC50131.1 - 0.01 16.1 0.2 0.059 13.6 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 EFC50131.1 - 0.011 15.7 0.1 0.08 12.9 0.1 2.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 EFC50131.1 - 0.016 15.0 0.0 0.089 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 EFC50131.1 - 0.018 15.5 1.1 0.89 10.0 0.3 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 EFC50131.1 - 0.022 13.5 0.0 0.055 12.3 0.0 1.6 1 0 0 1 1 1 0 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 EFC50131.1 - 0.032 14.1 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 EFC50131.1 - 0.041 14.4 0.4 0.13 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 EFC50131.1 - 0.051 13.5 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 EFC50131.1 - 0.097 12.2 0.0 0.2 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 EFC50131.1 - 0.16 11.3 0.0 0.32 10.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RHD3 PF05879.12 EFC50133.1 - 1.5e-99 334.2 5.5 1.9e-98 330.5 5.5 1.9 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 EFC50133.1 - 2.8e-06 27.5 0.3 8.6e-05 22.7 0.1 2.3 1 1 1 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 EFC50133.1 - 3.8e-05 23.7 0.0 6.7e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 EFC50133.1 - 0.013 15.7 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFC50133.1 - 0.018 14.9 0.0 0.053 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFC50133.1 - 0.046 14.1 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 EFC50133.1 - 0.12 12.4 0.0 0.36 10.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain Piezo_RRas_bdg PF12166.8 EFC50135.1 - 1.4e-95 321.2 8.4 1.4e-95 321.2 8.4 3.4 2 0 0 2 2 2 1 Piezo non-specific cation channel, R-Ras-binding domain zf-CRD PF17979.1 EFC50135.1 - 0.36 10.9 1.2 1.3 9.1 1.2 1.9 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions PNPase PF03726.14 EFC50135.1 - 5.9 7.5 15.3 0.15 12.6 0.1 4.4 3 1 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain EGF_2 PF07974.13 EFC50136.1 - 9.1e-09 35.5 62.0 0.00052 20.3 9.5 4.9 5 0 0 5 5 5 4 EGF-like domain Chordopox_A13L PF05961.11 EFC50136.1 - 0.0091 16.2 3.6 0.0091 16.2 3.6 2.3 2 0 0 2 2 2 1 Chordopoxvirus A13L protein Serine_rich PF08824.10 EFC50136.1 - 0.14 12.2 2.1 1.4 8.9 0.0 2.9 3 0 0 3 3 3 0 Serine rich protein interaction domain ERGIC_N PF13850.6 EFC50136.1 - 0.14 12.5 1.6 0.34 11.3 0.2 2.4 2 0 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Baculo_11_kDa PF06143.11 EFC50136.1 - 0.63 9.7 3.2 1.4 8.6 0.8 2.5 2 0 0 2 2 2 0 Baculovirus 11 kDa family Ninjurin PF04923.12 EFC50136.1 - 7.9 6.5 7.7 0.62 10.0 0.2 2.9 3 0 0 3 3 3 0 Ninjurin VWA PF00092.28 EFC50137.1 - 2e-14 54.2 1.7 2.7e-14 53.8 1.7 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 EFC50137.1 - 1.6e-13 51.2 0.4 3e-13 50.3 0.4 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 EFC50137.1 - 1.4e-08 34.9 0.1 1.7e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 EFC50137.1 - 1e-06 28.3 0.0 1.3e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 EFC50137.1 - 0.078 13.1 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus Apis_Csd PF11671.8 EFC50138.1 - 0.056 13.4 4.9 4 7.4 0.2 2.6 2 0 0 2 2 2 0 Complementary sex determiner protein DUF3328 PF11807.8 EFC50138.1 - 0.092 12.5 1.2 0.51 10.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) fn3_4 PF16794.5 EFC50138.1 - 0.29 11.1 1.0 0.57 10.1 0.0 2.0 2 0 0 2 2 2 0 Fibronectin-III type domain Myb_DNA-binding PF00249.31 EFC50140.1 - 2.3e-08 34.1 0.0 4.7e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-TRAF PF02176.18 EFC50141.1 - 5.9e-08 33.3 9.2 1.8e-07 31.7 9.2 1.9 1 0 0 1 1 1 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 EFC50141.1 - 0.00014 21.6 17.6 0.00038 20.2 17.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 EFC50141.1 - 0.00019 21.7 16.7 0.00019 21.7 16.7 2.3 2 0 0 2 2 2 1 Ring finger domain Sina PF03145.16 EFC50141.1 - 0.00036 20.5 6.5 0.00065 19.7 6.5 1.4 1 0 0 1 1 1 1 Seven in absentia protein family zf-C3HC4 PF00097.25 EFC50141.1 - 0.018 14.9 18.0 0.018 14.9 18.0 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) BRCT_3 PF18428.1 EFC50142.1 - 6.5e-10 39.0 0.0 7.5e-05 22.8 0.0 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT PF00533.26 EFC50142.1 - 2e-08 34.5 0.0 4.3e-06 27.0 0.0 3.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 EFC50142.1 - 0.00017 22.0 0.0 0.00089 19.6 0.0 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain SR-25 PF10500.9 EFC50142.1 - 6.4 6.3 22.2 0.56 9.8 9.3 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein C12orf66_like PF09404.10 EFC50143.1 - 9.7e-29 100.5 6.4 5.6e-17 61.7 1.8 2.6 2 0 0 2 2 2 2 KICSTOR complex C12orf66 like SUIM_assoc PF16619.5 EFC50143.1 - 0.0017 18.4 0.0 0.014 15.5 0.0 2.7 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 B9-C2 PF07162.11 EFC50144.1 - 2.8e-44 151.3 0.0 3.2e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Biopterin_H PF00351.21 EFC50145.1 - 4.6e-158 525.5 0.0 5.8e-158 525.2 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 EFC50145.1 - 0.0018 18.0 0.0 0.013 15.3 0.1 2.2 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 EFC50145.1 - 0.38 11.4 1.6 0.81 10.3 0.3 2.2 2 0 0 2 2 2 0 ACT domain zinc_ribbon_6 PF14599.6 EFC50146.1 - 8.3e-19 67.4 0.8 8.3e-19 67.4 0.8 4.4 2 1 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 EFC50146.1 - 3e-13 50.1 25.9 3e-13 50.1 25.9 3.5 1 1 2 3 3 3 2 CHY zinc finger zf-RING_2 PF13639.6 EFC50146.1 - 1.2e-08 35.2 6.6 1.2e-08 35.2 6.6 6.1 3 1 2 5 5 5 1 Ring finger domain zf-RING_5 PF14634.6 EFC50146.1 - 1.2e-06 28.3 6.5 1.2e-06 28.3 6.5 6.3 3 2 3 6 6 6 1 zinc-RING finger domain zf-C3HC4 PF00097.25 EFC50146.1 - 1.7e-06 27.7 7.3 1.7e-06 27.7 7.3 5.9 3 3 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 EFC50146.1 - 0.00035 20.3 2.5 0.00035 20.3 2.5 5.7 4 2 1 5 5 5 1 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 EFC50146.1 - 0.0059 16.5 0.2 0.0059 16.5 0.2 6.3 3 3 5 8 8 8 1 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 EFC50146.1 - 0.0072 16.2 2.7 0.0072 16.2 2.7 6.2 3 2 3 6 6 6 1 Prokaryotic RING finger family 4 HSP90 PF00183.18 EFC50147.1 - 1e-181 605.3 41.5 1e-181 605.3 41.5 1.6 2 0 0 2 2 2 1 Hsp90 protein HATPase_c PF02518.26 EFC50147.1 - 8.4e-11 42.4 0.1 1.9e-10 41.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 EFC50147.1 - 6.1e-10 39.1 0.3 6.1e-10 39.1 0.3 3.0 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mitoc_L55 PF09776.9 EFC50147.1 - 0.62 9.8 5.4 2.1 8.1 5.4 1.9 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 FAA_hydrolase PF01557.18 EFC50149.1 - 4.2e-36 124.7 0.0 5.3e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydro_N_2 PF18288.1 EFC50149.1 - 3.2e-19 69.1 0.0 6.2e-19 68.2 0.0 1.5 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal domain 2 AAA_18 PF13238.6 EFC50151.1 - 0.018 15.6 0.0 0.041 14.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain LRR_4 PF12799.7 EFC50152.1 - 1.4e-28 98.5 73.7 0.0003 21.1 1.7 13.6 9 3 2 12 12 12 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC50152.1 - 1.4e-23 82.4 58.7 1.8e-05 24.4 1.4 10.3 8 2 2 10 10 10 7 Leucine rich repeat LRR_9 PF14580.6 EFC50152.1 - 0.00026 20.6 40.2 0.0063 16.0 0.1 7.6 6 2 1 7 7 7 3 Leucine-rich repeat Phosphodiest PF01663.22 EFC50152.1 - 0.0011 18.6 1.7 0.0025 17.4 0.9 1.8 1 1 1 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 EFC50152.1 - 0.014 14.7 0.8 0.034 13.5 0.2 1.9 2 0 0 2 2 2 0 Metalloenzyme superfamily LRR_6 PF13516.6 EFC50152.1 - 0.089 12.9 54.1 11 6.3 0.0 13.9 15 1 1 16 16 16 0 Leucine Rich repeat Syndecan PF01034.20 EFC50152.1 - 9.7 6.2 11.7 0.16 11.9 1.8 3.0 3 0 0 3 3 3 0 Syndecan domain Profilin PF00235.19 EFC50153.1 - 3.2e-24 85.6 0.0 3.6e-24 85.5 0.0 1.0 1 0 0 1 1 1 1 Profilin GCP_N_terminal PF17681.1 EFC50155.1 - 1.4e-79 267.9 0.1 1.4e-78 264.6 0.0 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 EFC50155.1 - 1.2e-55 189.2 3.5 2.8e-55 188.0 3.5 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Trans_coact PF16805.5 EFC50155.1 - 0.064 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Phage late-transcription coactivator FAM70 PF14967.6 EFC50156.1 - 0.021 14.3 1.0 0.025 14.1 1.0 1.0 1 0 0 1 1 1 0 FAM70 protein DUF4855 PF16147.5 EFC50157.1 - 0.18 10.8 2.1 1.2 8.1 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4855) FAM70 PF14967.6 EFC50157.1 - 0.28 10.6 0.6 0.45 9.9 0.6 1.2 1 0 0 1 1 1 0 FAM70 protein NHL PF01436.21 EFC50158.1 - 1.9e-20 71.8 1.9 2.5e-05 24.1 0.0 7.1 7 1 1 8 8 7 3 NHL repeat Pkinase PF00069.25 EFC50158.1 - 5.8e-10 39.0 0.0 8.5e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain EGF_2 PF07974.13 EFC50158.1 - 2.7e-08 34.0 65.0 0.00017 21.9 7.8 5.7 5 0 0 5 5 5 3 EGF-like domain TMEM154 PF15102.6 EFC50158.1 - 1.3e-06 28.4 5.1 1.6e-06 28.1 4.2 1.6 1 1 0 1 1 1 1 TMEM154 protein family Pkinase_Tyr PF07714.17 EFC50158.1 - 0.00017 20.9 0.1 0.00031 20.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Orf78 PF06024.12 EFC50158.1 - 0.0028 17.9 0.6 0.0057 16.9 0.6 1.4 1 0 0 1 1 1 1 Orf78 (ac78) ODV-E18 PF10717.9 EFC50158.1 - 0.015 15.1 5.2 0.017 15.0 3.3 2.1 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF4834 PF16118.5 EFC50158.1 - 0.04 14.9 0.1 0.11 13.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 EFC50158.1 - 0.075 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3377 PF11857.8 EFC50158.1 - 0.26 11.3 1.7 0.67 9.9 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Baculo_11_kDa PF06143.11 EFC50158.1 - 0.78 9.4 5.7 2.1 8.0 5.7 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family Rubrerythrin PF02915.17 EFC50160.1 - 1.9e-26 93.1 1.4 5.4e-26 91.6 1.4 1.7 1 1 0 1 1 1 1 Rubrerythrin Ferritin PF00210.24 EFC50160.1 - 5.3e-07 29.7 0.6 0.0013 18.6 0.1 2.1 1 1 1 2 2 2 2 Ferritin-like domain DUF892 PF05974.12 EFC50160.1 - 0.062 13.3 0.2 0.33 11.0 0.1 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF892) ZIP4_domain PF18292.1 EFC50162.1 - 0.0026 17.7 1.1 0.0069 16.3 1.1 1.7 1 0 0 1 1 1 1 Zinc transporter ZIP4 domain DUF2540 PF10802.8 EFC50162.1 - 0.049 13.7 0.1 0.16 12.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) Helicase_C PF00271.31 EFC50163.1 - 1.8e-19 70.1 1.7 1.2e-18 67.5 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFC50163.1 - 2.8e-13 49.3 0.2 9.3e-13 47.6 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain ERCC3_RAD25_C PF16203.5 EFC50163.1 - 2e-10 40.3 8.1 2e-10 40.3 8.1 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 EFC50163.1 - 3.9e-07 29.5 1.7 3.9e-07 29.5 1.7 2.9 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 SPG4 PF17325.2 EFC50163.1 - 2.5 9.2 11.3 4.9 8.3 1.9 2.7 2 0 0 2 2 2 0 Stationary phase protein 4 YqfD PF06898.11 EFC50164.1 - 0.019 13.8 8.1 0.027 13.3 8.1 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD CENP-B_dimeris PF09026.10 EFC50165.1 - 6.9 7.1 12.2 13 6.3 12.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-CCCH PF00642.24 EFC50166.1 - 1.8e-10 40.4 3.1 4e-10 39.3 3.1 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 EFC50166.1 - 1.7e-05 24.6 9.6 3.1e-05 23.8 9.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 EFC50166.1 - 2.7e-05 24.1 11.8 2.7e-05 24.1 11.8 2.0 2 0 0 2 2 2 1 RING-type zinc-finger zf_CCCH_4 PF18345.1 EFC50166.1 - 3.2e-05 23.8 6.8 7.7e-05 22.6 6.8 1.7 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4_2 PF13923.6 EFC50166.1 - 8.7e-05 22.3 11.5 8.7e-05 22.3 11.5 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 EFC50166.1 - 0.00018 21.3 13.6 0.00018 21.3 13.6 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 EFC50166.1 - 0.00019 21.1 3.1 0.00019 21.1 3.1 1.7 2 0 0 2 2 1 1 CCCH-type zinc finger zf-RING_5 PF14634.6 EFC50166.1 - 0.0012 18.7 12.8 0.0024 17.8 12.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 EFC50166.1 - 0.026 14.7 12.8 0.026 14.7 12.8 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 EFC50166.1 - 0.035 14.5 11.1 0.035 14.5 11.1 1.9 2 0 0 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 EFC50166.1 - 0.042 13.7 9.3 0.094 12.6 9.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_10 PF16685.5 EFC50166.1 - 0.081 13.1 9.6 0.082 13.1 7.9 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 Seryl_tRNA_N PF02403.22 EFC50167.1 - 0.0012 19.0 25.2 0.025 14.8 5.3 2.7 1 1 1 2 2 2 2 Seryl-tRNA synthetase N-terminal domain HSA PF07529.13 EFC50167.1 - 0.0016 18.7 16.6 0.021 15.1 9.5 2.4 1 1 1 2 2 2 2 HSA TipAS PF07739.13 EFC50167.1 - 0.093 13.3 11.4 0.54 10.8 7.3 3.2 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain DUF3584 PF12128.8 EFC50167.1 - 0.12 9.9 19.8 0.15 9.5 19.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4618 PF15397.6 EFC50167.1 - 0.2 11.0 22.8 0.49 9.8 22.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) FAM184 PF15665.5 EFC50167.1 - 0.26 11.1 27.4 1.2 8.9 27.4 1.9 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B Ax_dynein_light PF10211.9 EFC50167.1 - 0.36 10.7 28.3 3.4 7.6 14.9 2.6 1 1 1 2 2 2 0 Axonemal dynein light chain Spc7 PF08317.11 EFC50167.1 - 0.39 9.6 22.1 0.57 9.0 22.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 EFC50167.1 - 0.51 9.6 10.8 0.73 9.1 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 EFC50167.1 - 0.61 8.9 5.0 0.79 8.6 5.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 EFC50167.1 - 0.65 10.0 11.1 0.54 10.3 8.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Lectin_N PF03954.14 EFC50167.1 - 0.7 9.6 6.8 0.35 10.6 4.1 1.8 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Syntaxin-6_N PF09177.11 EFC50167.1 - 0.79 10.3 15.3 0.5 10.9 2.4 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal AAA_11 PF13086.6 EFC50167.1 - 0.89 9.3 9.0 1.4 8.6 9.0 1.3 1 0 0 1 1 1 0 AAA domain FUSC PF04632.12 EFC50167.1 - 1.1 7.7 2.3 1.3 7.4 2.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pannexin_like PF12534.8 EFC50167.1 - 1.1 8.3 9.0 3.2 6.8 9.0 1.7 1 1 0 1 1 1 0 Pannexin-like TM region of LRRC8 Phage_Mu_Gam PF07352.12 EFC50167.1 - 1.2 9.1 21.2 0.23 11.4 5.4 2.5 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein Rootletin PF15035.6 EFC50167.1 - 1.2 9.1 20.4 0.059 13.4 9.2 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion TerB_C PF15615.6 EFC50167.1 - 1.4 9.2 14.4 6.4 7.1 14.4 2.0 1 1 0 1 1 1 0 TerB-C domain Atg14 PF10186.9 EFC50167.1 - 2 7.4 17.3 3.1 6.8 17.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 BSD PF03909.17 EFC50167.1 - 2 8.5 6.3 3.2 7.8 0.2 3.0 2 1 0 3 3 2 0 BSD domain CCDC92 PF14916.6 EFC50167.1 - 2.1 8.1 22.6 6.5 6.6 2.9 4.1 1 1 1 3 3 3 0 Coiled-coil domain of unknown function bZIP_1 PF00170.21 EFC50167.1 - 2.8 8.1 28.0 4 7.6 1.5 3.7 2 1 0 3 3 3 0 bZIP transcription factor Cnn_1N PF07989.11 EFC50167.1 - 3 8.1 28.4 3.7 7.8 5.3 3.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 TMPIT PF07851.13 EFC50167.1 - 4.3 6.5 18.5 88 2.2 18.5 2.1 1 1 0 1 1 1 0 TMPIT-like protein ZapB PF06005.12 EFC50167.1 - 4.9 7.7 32.7 1.8e+04 -13.5 32.7 3.5 1 1 0 1 1 0 0 Cell division protein ZapB FliT PF05400.13 EFC50167.1 - 5.5 7.9 19.6 0.92 10.4 4.4 2.7 1 1 1 2 2 2 0 Flagellar protein FliT CENP-H PF05837.12 EFC50167.1 - 6.7 7.2 26.3 28 5.2 11.9 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) XkdW PF09636.10 EFC50167.1 - 8.2 6.6 13.5 5.4 7.1 6.3 2.6 2 0 0 2 2 2 0 XkdW protein YtxH PF12732.7 EFC50167.1 - 9.2 6.9 11.4 4.5 7.9 5.8 3.0 2 1 0 2 2 2 0 YtxH-like protein Ras PF00071.22 EFC50168.1 - 2.7e-40 137.6 0.0 4e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50168.1 - 4.9e-21 75.2 0.0 8.9e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase F-box-like PF12937.7 EFC50168.1 - 1.8e-15 56.5 0.5 3.1e-15 55.8 0.5 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 EFC50168.1 - 6.8e-09 35.4 0.3 1.8e-08 34.0 0.3 1.7 1 0 0 1 1 1 1 F-box domain GTP_EFTU PF00009.27 EFC50168.1 - 2.5e-05 23.9 0.0 0.00022 20.8 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC50168.1 - 0.0003 20.3 0.0 0.00067 19.2 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family F-box_4 PF15966.5 EFC50168.1 - 0.0015 18.4 0.0 0.0037 17.1 0.0 1.6 1 0 0 1 1 1 1 F-box MMR_HSR1 PF01926.23 EFC50168.1 - 0.005 16.9 0.0 0.0087 16.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF5506 PF17611.2 EFC50168.1 - 0.028 14.3 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5506) AAA_16 PF13191.6 EFC50168.1 - 0.049 14.0 0.0 0.079 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SRPRB PF09439.10 EFC50168.1 - 0.099 12.1 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit F-box_5 PF18511.1 EFC50168.1 - 0.38 10.3 3.2 1.2 8.7 3.2 1.8 2 0 0 2 2 2 0 F-box Pep3_Vps18 PF05131.14 EFC50169.1 - 6.1e-28 97.5 1.9 1.2e-19 70.6 0.0 3.5 3 0 0 3 3 3 2 Pep3/Vps18/deep orange family Clathrin PF00637.20 EFC50169.1 - 6.2e-19 68.3 21.7 1.5e-18 67.1 5.8 4.1 4 0 0 4 4 4 2 Region in Clathrin and VPS Vps39_2 PF10367.9 EFC50169.1 - 0.012 16.1 0.1 0.13 12.7 0.0 2.9 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 DUF2560 PF10834.8 EFC50169.1 - 0.058 13.6 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2560) ORF6C PF10552.9 EFC50169.1 - 0.22 11.6 6.8 0.41 10.8 0.3 3.8 4 0 0 4 4 4 0 ORF6C domain IFP_35_N PF07334.13 EFC50169.1 - 5.8 7.1 6.7 0.46 10.6 0.7 2.3 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus XhlA PF10779.9 EFC50169.1 - 8.4 6.7 8.3 2 8.7 3.4 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Gtr1_RagA PF04670.12 EFC50170.1 - 4.6e-72 242.1 4.3 4.6e-72 242.1 4.3 1.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 EFC50170.1 - 1.2e-06 28.1 0.1 2.5e-06 27.1 0.1 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 EFC50170.1 - 3.4e-06 26.6 0.2 7e-06 25.6 0.2 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC50170.1 - 1.6e-05 25.1 0.1 3.3e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC50170.1 - 3.2e-05 24.0 0.2 0.0001 22.3 0.0 2.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC50170.1 - 0.0024 17.5 0.4 0.0044 16.6 0.4 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 EFC50170.1 - 0.0036 17.1 0.4 0.006 16.4 0.4 1.6 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Ras PF00071.22 EFC50170.1 - 0.009 15.6 0.2 0.009 15.6 0.2 2.1 2 0 0 2 2 2 1 Ras family AAA_16 PF13191.6 EFC50170.1 - 0.084 13.3 0.0 0.37 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 EFC50170.1 - 0.26 10.4 10.1 0.0093 15.2 3.0 1.9 2 1 0 2 2 2 0 G-protein alpha subunit PhoPQ_related PF10142.9 EFC50171.1 - 2.8e-95 319.1 0.3 3.4e-95 318.8 0.3 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein DSPc PF00782.20 EFC50172.1 - 1.4e-19 70.3 0.1 5e-19 68.4 0.1 2.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain p25-alpha PF05517.12 EFC50172.1 - 2.3e-08 34.4 3.8 2.3e-08 34.4 3.8 2.8 3 0 0 3 3 3 1 p25-alpha NHL PF01436.21 EFC50172.1 - 7.7e-07 28.8 0.5 0.0002 21.2 0.8 3.6 3 0 0 3 3 3 1 NHL repeat Y_phosphatase PF00102.27 EFC50172.1 - 0.0019 17.8 0.0 0.0047 16.5 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase LRR_4 PF12799.7 EFC50172.1 - 0.0038 17.6 8.7 0.013 15.9 0.4 4.6 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC50172.1 - 0.0077 16.0 1.3 0.29 10.9 0.3 3.8 3 1 1 4 4 4 1 Leucine rich repeat Y_phosphatase2 PF03162.13 EFC50172.1 - 0.014 15.0 0.7 0.13 11.8 0.1 2.6 1 1 1 2 2 2 0 Tyrosine phosphatase family LRR_1 PF00560.33 EFC50172.1 - 0.32 11.7 2.9 7.2 7.6 0.1 4.4 3 0 0 3 3 3 0 Leucine Rich Repeat MMR_HSR1 PF01926.23 EFC50173.1 - 3.2e-44 149.7 0.8 1.2e-21 76.9 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC50173.1 - 2.5e-22 79.4 7.4 1e-12 48.0 0.4 3.2 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain KH_dom-like PF14714.6 EFC50173.1 - 9.6e-20 70.7 1.2 1.5e-18 66.8 2.0 2.4 2 0 0 2 2 2 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 EFC50173.1 - 4.1e-18 65.4 2.9 3.8e-08 33.0 0.6 3.5 2 2 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC50173.1 - 1e-12 48.3 1.8 5.8e-05 23.1 0.0 4.2 5 0 0 5 5 5 3 RsgA GTPase Dynamin_N PF00350.23 EFC50173.1 - 5.7e-11 42.8 11.8 1.1e-05 25.6 0.5 4.6 3 2 2 5 5 5 3 Dynamin family Roc PF08477.13 EFC50173.1 - 2.6e-10 40.6 1.5 0.0003 21.0 0.1 3.7 2 2 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50173.1 - 5.8e-10 38.9 1.2 0.0084 15.6 0.0 3.8 3 0 0 3 3 3 3 ADP-ribosylation factor family AIG1 PF04548.16 EFC50173.1 - 6.7e-09 35.4 2.8 0.0016 17.8 0.3 3.2 2 1 0 2 2 2 2 AIG1 family Ras PF00071.22 EFC50173.1 - 7.3e-09 35.4 2.8 2.8e-06 27.0 0.5 3.3 2 2 0 2 2 2 2 Ras family Septin PF00735.18 EFC50173.1 - 3.2e-07 29.9 0.5 0.0062 15.9 0.1 2.6 2 0 0 2 2 2 2 Septin SRPRB PF09439.10 EFC50173.1 - 5.4e-07 29.2 2.0 0.0021 17.5 0.4 3.6 2 2 0 2 2 2 2 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 EFC50173.1 - 9.2e-07 29.5 7.8 0.004 17.7 0.9 3.4 2 2 1 3 3 3 2 ABC transporter TniB PF05621.11 EFC50173.1 - 4.6e-06 26.2 0.4 0.0036 16.7 0.1 2.7 2 0 0 2 2 2 2 Bacterial TniB protein AAA_22 PF13401.6 EFC50173.1 - 1.6e-05 25.2 0.9 0.01 16.1 0.1 3.0 3 0 0 3 3 2 1 AAA domain ATPase_2 PF01637.18 EFC50173.1 - 2.7e-05 24.2 0.1 0.084 12.8 0.0 2.8 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea AAA_29 PF13555.6 EFC50173.1 - 0.00025 20.7 0.1 0.86 9.4 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1_Xtn PF16897.5 EFC50173.1 - 0.00044 20.2 0.1 0.1 12.7 0.0 3.0 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain PduV-EutP PF10662.9 EFC50173.1 - 0.00058 19.6 0.4 2 8.2 0.0 3.5 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 EFC50173.1 - 0.00059 19.6 0.1 1.1 8.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 EFC50173.1 - 0.0022 18.1 4.3 3.6 7.6 0.1 3.6 3 1 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 EFC50173.1 - 0.0028 18.0 0.0 0.83 10.1 0.0 2.9 2 0 0 2 2 2 1 RNA helicase MeaB PF03308.16 EFC50173.1 - 0.003 16.6 0.4 9.3 5.1 0.0 4.0 4 1 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 EFC50173.1 - 0.0033 17.7 1.0 2.2 8.5 0.0 3.5 3 1 1 4 4 4 1 AAA domain GBP PF02263.19 EFC50173.1 - 0.0043 16.3 0.1 0.72 9.1 0.0 2.4 2 0 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MobB PF03205.14 EFC50173.1 - 0.0059 16.5 0.3 0.42 10.5 0.1 2.7 2 1 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Guanylate_kin PF00625.21 EFC50173.1 - 0.015 15.0 0.2 0.37 10.5 0.1 2.6 2 0 0 2 2 2 0 Guanylate kinase FtsK_SpoIIIE PF01580.18 EFC50173.1 - 0.037 13.4 0.1 2.9 7.2 0.0 2.7 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_16 PF13191.6 EFC50173.1 - 0.061 13.7 0.0 11 6.3 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain G-alpha PF00503.20 EFC50173.1 - 0.077 12.1 5.2 1.7 7.7 0.1 3.3 2 1 0 2 2 2 0 G-protein alpha subunit Ribosomal_L13 PF00572.18 EFC50174.1 - 1.5e-47 161.0 0.2 1.7e-47 160.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 ATPase_2 PF01637.18 EFC50175.1 - 3.2e-06 27.2 0.9 7.7e-06 26.0 0.4 2.1 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 EFC50175.1 - 1.5e-05 25.3 0.2 7.8e-05 23.0 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 EFC50175.1 - 3.5e-05 24.2 0.0 0.00012 22.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 EFC50175.1 - 4.7e-05 23.4 0.2 0.00012 22.0 0.2 1.7 1 0 0 1 1 1 1 NACHT domain DUF815 PF05673.13 EFC50175.1 - 0.0032 16.7 0.3 0.0098 15.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 EFC50175.1 - 0.0097 16.4 8.1 0.014 15.9 0.1 2.8 1 1 0 2 2 2 1 ABC transporter TsaE PF02367.17 EFC50175.1 - 0.017 15.1 0.0 0.039 14.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Torsin PF06309.11 EFC50175.1 - 0.039 14.1 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 Torsin AAA_16 PF13191.6 EFC50175.1 - 0.043 14.2 0.0 0.15 12.4 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain MobB PF03205.14 EFC50175.1 - 0.069 13.1 0.3 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FAST_1 PF06743.15 EFC50175.1 - 0.074 13.0 0.1 1.1 9.3 0.1 2.7 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 RNA_helicase PF00910.22 EFC50175.1 - 0.12 12.8 0.2 0.12 12.8 0.2 3.2 3 1 0 3 3 3 0 RNA helicase Slx4 PF09494.10 EFC50175.1 - 0.24 11.4 2.1 19 5.3 0.1 3.6 2 1 1 3 3 3 0 Slx4 endonuclease FANCI_S2 PF14676.6 EFC50176.1 - 0.00062 20.1 3.9 0.0012 19.2 0.1 3.2 3 0 0 3 3 3 1 FANCI solenoid 2 HYLS1_C PF15311.6 EFC50176.1 - 0.068 13.9 2.8 0.3 11.9 2.8 2.2 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus DUF4597 PF15366.6 EFC50177.1 - 0.02 14.7 0.1 0.079 12.7 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4597) GLE1 PF07817.13 EFC50178.1 - 4.5e-44 150.6 0.5 4.5e-44 150.6 0.5 1.9 2 0 0 2 2 2 1 GLE1-like protein TadE PF07811.12 EFC50178.1 - 0.027 14.8 0.1 0.05 13.9 0.1 1.5 1 0 0 1 1 1 0 TadE-like protein Tox-REase-3 PF15647.6 EFC50178.1 - 0.029 14.6 0.5 0.029 14.6 0.5 2.2 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 3 DUF3149 PF11346.8 EFC50178.1 - 1.1 8.9 8.1 3.7 7.3 3.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) DNA_topoisoIV PF00521.20 EFC50179.1 - 1.9e-135 452.1 2.6 6.4e-135 450.3 2.6 2.0 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 EFC50179.1 - 6.6e-47 159.0 5.7 6.6e-47 159.0 5.7 2.9 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 EFC50179.1 - 2e-20 73.0 3.0 8e-20 71.0 3.0 2.1 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 EFC50179.1 - 3.4e-14 53.3 0.9 5.3e-13 49.5 0.0 2.9 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 EFC50179.1 - 2.7e-06 27.5 0.0 2.5e-05 24.5 0.0 2.8 1 0 0 1 1 1 1 Toprim domain Guanylate_cyc PF00211.20 EFC50180.1 - 5.3e-27 94.6 0.0 1.3e-26 93.3 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Hydant_A_N PF05378.13 EFC50180.1 - 0.095 12.4 0.2 0.28 10.9 0.2 1.8 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region Thioredoxin PF00085.20 EFC50181.1 - 3.9e-08 33.2 0.0 6.2e-05 22.9 0.1 2.3 2 0 0 2 2 2 2 Thioredoxin CD34_antigen PF06365.12 EFC50181.1 - 0.083 12.5 0.4 0.14 11.7 0.4 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Thioredoxin PF00085.20 EFC50182.1 - 1.1e-59 198.8 0.9 6.4e-31 106.4 0.3 2.4 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 EFC50182.1 - 2.3e-21 76.5 0.3 6.1e-21 75.1 0.3 1.8 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 EFC50182.1 - 5.3e-16 58.8 0.0 2.2e-08 33.8 0.0 2.1 1 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 EFC50182.1 - 4.2e-15 56.1 1.3 3.5e-07 30.7 0.5 2.9 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 EFC50182.1 - 1.9e-10 40.9 0.3 0.00023 21.4 0.2 3.4 2 2 1 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 EFC50182.1 - 2.4e-10 40.4 0.4 0.00049 20.0 0.0 3.2 2 1 0 2 2 2 2 AhpC/TSA family Thioredoxin_7 PF13899.6 EFC50182.1 - 4.5e-09 36.4 0.2 0.00014 22.0 0.1 2.5 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_6 PF13848.6 EFC50182.1 - 2.3e-06 27.6 0.0 1.3e-05 25.2 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 EFC50182.1 - 6.7e-06 25.9 4.0 0.0068 16.1 0.1 2.6 3 0 0 3 3 3 2 Redoxin HyaE PF07449.11 EFC50182.1 - 0.048 13.6 0.0 3.4 7.7 0.0 2.6 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE TraF PF13728.6 EFC50182.1 - 0.083 12.7 0.0 2.8 7.7 0.0 2.3 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_4 PF13462.6 EFC50182.1 - 0.17 12.1 5.5 2.8 8.1 0.4 2.9 3 0 0 3 3 3 0 Thioredoxin Glutaredoxin PF00462.24 EFC50182.1 - 0.29 11.4 5.9 13 6.1 2.3 3.4 2 1 0 2 2 2 0 Glutaredoxin TPR_2 PF07719.17 EFC50183.1 - 1.5e-11 43.5 30.4 0.00082 19.3 0.3 9.2 11 1 1 12 12 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50183.1 - 1.2e-09 38.5 8.7 0.012 16.1 0.2 5.6 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50183.1 - 6.2e-07 30.0 0.1 0.12 13.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50183.1 - 2.2e-05 24.7 13.1 2.3 8.6 0.3 6.9 3 3 3 7 7 7 2 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 EFC50183.1 - 3.6e-05 23.4 0.1 0.032 13.9 0.0 3.2 2 1 1 3 3 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 EFC50183.1 - 5.9e-05 23.4 21.4 0.25 12.1 0.2 7.7 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50183.1 - 0.00013 21.6 31.7 0.17 11.8 0.1 8.1 9 0 0 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50183.1 - 0.0007 19.8 28.3 0.0058 16.8 4.3 5.3 4 1 2 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 EFC50183.1 - 0.019 14.6 1.7 0.019 14.6 1.7 4.7 5 0 0 5 5 5 0 TPR repeat TPR_7 PF13176.6 EFC50183.1 - 0.021 14.8 6.8 7.6 6.8 0.0 6.5 8 0 0 8 8 7 0 Tetratricopeptide repeat DUF2207 PF09972.9 EFC50183.1 - 0.13 11.0 1.1 9.3 4.9 0.0 2.5 2 1 0 3 3 3 0 Predicted membrane protein (DUF2207) TPR_8 PF13181.6 EFC50183.1 - 0.46 10.8 24.2 3.9 7.9 0.4 7.4 7 1 1 8 8 8 0 Tetratricopeptide repeat 5_nucleotid PF05761.14 EFC50184.1 - 5.3e-155 516.8 7.1 6e-155 516.6 7.1 1.0 1 0 0 1 1 1 1 5' nucleotidase family DUF234 PF03008.14 EFC50184.1 - 0.039 14.4 0.2 2.1 8.8 0.0 2.7 2 0 0 2 2 2 0 Archaea bacterial proteins of unknown function HAD_2 PF13419.6 EFC50184.1 - 0.061 13.4 0.0 2 8.4 0.0 2.8 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Nup84_Nup100 PF04121.13 EFC50185.1 - 5.8e-146 487.6 29.8 7.9e-146 487.1 29.8 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 RPN5_C PF18098.1 EFC50186.1 - 0.083 13.0 2.0 0.73 10.0 0.1 2.7 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN5 C-terminal domain DUF4279 PF14106.6 EFC50186.1 - 0.49 10.6 2.7 0.65 10.2 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4279) PPR PF01535.20 EFC50187.1 - 2.9e-24 83.5 19.2 5.5e-05 23.2 0.1 10.8 11 0 0 11 11 11 6 PPR repeat PPR_2 PF13041.6 EFC50187.1 - 6.4e-22 77.5 30.9 3e-05 24.1 0.1 12.3 9 3 4 13 13 13 5 PPR repeat family PPR_1 PF12854.7 EFC50187.1 - 7.5e-15 54.3 3.7 0.00019 21.0 0.0 7.3 9 0 0 9 9 9 3 PPR repeat PPR_3 PF13812.6 EFC50187.1 - 2.4e-13 49.9 33.2 0.00029 20.8 0.1 9.6 7 4 3 10 10 10 3 Pentatricopeptide repeat domain Clathrin PF00637.20 EFC50187.1 - 4.1e-05 23.5 1.8 4.1e-05 23.5 1.8 7.0 3 2 2 6 6 6 1 Region in Clathrin and VPS TPR_19 PF14559.6 EFC50187.1 - 0.0038 17.7 1.5 2.8 8.5 0.2 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50187.1 - 0.011 16.5 0.0 8.6 7.5 0.1 4.1 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50187.1 - 0.18 12.2 1.1 5 7.5 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5131 PF07505.11 EFC50187.1 - 0.19 11.2 0.9 1.7 8.0 0.2 2.7 1 1 1 3 3 3 0 Protein of unknown function (DUF5131) Phage_antitermQ PF06530.12 EFC50187.1 - 0.3 11.0 5.1 4 7.4 0.1 3.9 3 1 1 4 4 4 0 Phage antitermination protein Q Pro-kuma_activ PF09286.11 EFC50187.1 - 1.3 9.3 8.1 6.6 7.0 0.1 4.7 5 0 0 5 5 5 0 Pro-kumamolisin, activation domain WD40 PF00400.32 EFC50188.1 - 1.6e-13 50.9 13.0 0.0052 17.6 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50188.1 - 1.7e-13 50.6 3.3 0.0079 16.5 0.0 6.2 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC50188.1 - 1.2e-05 25.2 3.5 0.075 12.9 0.1 5.0 3 1 2 5 5 5 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 EFC50188.1 - 0.0015 16.6 0.4 0.34 8.8 0.0 2.9 2 1 1 3 3 3 2 IKI3 family PD40 PF07676.12 EFC50188.1 - 0.0038 17.1 3.2 0.27 11.2 0.6 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat V-SNARE PF05008.15 EFC50188.1 - 0.097 13.1 0.2 0.56 10.6 0.1 2.1 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus TPR_19 PF14559.6 EFC50188.1 - 0.11 13.0 0.6 1.4 9.5 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2207 PF09972.9 EFC50190.1 - 4.8 5.8 8.8 5.7 5.6 8.8 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) CTP_transf_like PF01467.26 EFC50192.1 - 7.1e-29 100.8 0.0 9e-29 100.5 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like SpoVAD PF07451.11 EFC50192.1 - 0.19 10.4 0.0 0.28 9.8 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Presenilin PF01080.17 EFC50193.1 - 0.66 8.7 3.7 1.2 7.8 3.7 1.4 1 0 0 1 1 1 0 Presenilin Big_1 PF02369.16 EFC50193.1 - 4.3 7.4 6.8 0.35 10.9 0.3 2.7 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 1) SWIB PF02201.18 EFC50194.1 - 2.1e-10 40.3 0.2 7.4e-10 38.6 0.2 2.1 1 0 0 1 1 1 1 SWIB/MDM2 domain DUF1323 PF07037.11 EFC50194.1 - 0.69 10.3 3.5 1.3 9.5 0.3 2.7 2 0 0 2 2 2 0 Putative transcription regulator (DUF1323) Raptor_N PF14538.6 EFC50194.1 - 5.7 6.9 8.5 0.93 9.4 0.4 2.9 3 1 0 3 3 3 0 Raptor N-terminal CASPase like domain Ion_trans PF00520.31 EFC50195.1 - 5.2e-14 52.1 18.5 1e-13 51.1 18.5 1.4 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 EFC50195.1 - 3.8e-12 46.0 6.6 3.8e-12 46.0 6.6 2.3 3 0 0 3 3 3 1 Ion channel BK_channel_a PF03493.18 EFC50195.1 - 6.1e-12 45.6 1.1 2.6e-11 43.6 0.2 2.5 2 0 0 2 2 2 1 Calcium-activated BK potassium channel alpha subunit TrkA_N PF02254.18 EFC50195.1 - 3e-06 27.5 0.1 2.1e-05 24.8 0.0 2.6 3 0 0 3 3 3 1 TrkA-N domain TrkA_C PF02080.21 EFC50195.1 - 0.045 13.6 0.0 0.33 10.8 0.0 2.4 2 0 0 2 2 2 0 TrkA-C domain DEAD PF00270.29 EFC50196.1 - 5.7e-40 136.9 0.0 1.2e-39 135.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50196.1 - 8e-32 109.9 0.5 7.8e-31 106.7 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50196.1 - 1.7e-05 24.9 0.0 4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFC50196.1 - 0.071 12.4 0.0 0.24 10.7 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit RNA_pol_RpbG PF16992.5 EFC50196.1 - 0.074 13.1 0.8 0.29 11.2 0.1 2.4 3 0 0 3 3 3 0 DNA-directed RNA polymerase, subunit G zf-CCHC PF00098.23 EFC50196.1 - 0.096 12.8 2.6 0.19 11.8 2.6 1.5 1 0 0 1 1 1 0 Zinc knuckle Copper-fist PF00649.18 EFC50196.1 - 0.18 11.4 1.2 0.45 10.0 1.2 1.7 1 0 0 1 1 1 0 Copper fist DNA binding domain PH PF00169.29 EFC50197.1 - 8.4e-05 23.0 4.1 8.4e-05 23.0 4.1 2.5 2 2 2 4 4 4 1 PH domain Pkinase PF00069.25 EFC50198.1 - 3.8e-20 72.4 0.0 7e-12 45.3 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain WD40 PF00400.32 EFC50198.1 - 1.7e-10 41.3 12.0 0.00014 22.5 0.7 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat HEAT PF02985.22 EFC50198.1 - 2.9e-06 27.0 3.4 2.8 8.4 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat Pkinase_Tyr PF07714.17 EFC50198.1 - 5.9e-05 22.5 0.0 0.00086 18.7 0.0 2.5 3 0 0 3 3 3 1 Protein tyrosine kinase RTP1_C1 PF10363.9 EFC50198.1 - 0.02 15.1 1.3 4.2 7.6 0.1 3.4 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 TolB_N PF04052.13 EFC50198.1 - 0.052 13.7 0.3 0.21 11.8 0.3 2.1 1 0 0 1 1 1 0 TolB amino-terminal domain SIR2 PF02146.17 EFC50199.1 - 4.1e-28 98.5 3.6 3.6e-22 79.1 0.1 2.9 2 1 1 3 3 3 2 Sir2 family LodA_N PF17990.1 EFC50199.1 - 0.0054 16.7 1.7 0.011 15.6 1.3 1.7 1 1 0 1 1 1 1 L-Lysine epsilon oxidase N-terminal Ndc1_Nup PF09531.10 EFC50199.1 - 2 7.0 12.8 2.5 6.7 12.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase PF00069.25 EFC50200.1 - 5.1e-41 140.8 0.1 5.8e-41 140.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50200.1 - 1.4e-23 83.5 0.0 1.6e-23 83.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC50200.1 - 0.0017 17.4 0.4 0.005 15.8 0.4 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFC50200.1 - 0.0018 17.7 0.0 0.0035 16.7 0.0 1.5 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 EFC50200.1 - 0.0071 15.7 0.0 0.0099 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 EFC50200.1 - 0.029 14.0 0.2 0.039 13.6 0.2 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 EFC50200.1 - 0.061 13.2 0.0 0.083 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 EFC50200.1 - 0.18 10.6 0.0 0.21 10.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase RNase_PH PF01138.21 EFC50201.1 - 6e-31 107.7 0.1 9.4e-31 107.1 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFC50201.1 - 9.7e-06 25.5 0.1 2.1e-05 24.5 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Synaptobrevin PF00957.21 EFC50202.1 - 2e-25 88.4 2.2 2.9e-25 87.9 2.2 1.3 1 0 0 1 1 1 1 Synaptobrevin EMP24_GP25L PF01105.24 EFC50202.1 - 0.0018 18.2 0.6 0.0026 17.8 0.6 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Man-6-P_recep PF02157.15 EFC50202.1 - 0.0025 16.9 0.3 0.0028 16.8 0.3 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate receptor DUF2207 PF09972.9 EFC50202.1 - 0.0051 15.6 0.6 0.006 15.4 0.6 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) JIP_LZII PF16471.5 EFC50202.1 - 0.26 11.5 2.7 0.79 9.9 2.7 1.8 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II S_4TM PF18159.1 EFC50202.1 - 3.1 7.0 6.1 2.8 7.2 0.1 2.1 1 1 1 2 2 2 0 SMODS-associating 4TM effector domain LMBR1 PF04791.16 EFC50202.1 - 3.6 6.4 7.4 0.4 9.5 1.2 1.9 1 1 1 2 2 2 0 LMBR1-like membrane protein DnaJ_C PF01556.18 EFC50204.1 - 4.7e-43 146.8 1.3 6.7e-43 146.3 1.3 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFC50204.1 - 8.1e-25 86.7 6.0 1.5e-24 85.9 6.0 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 EFC50204.1 - 3e-14 53.1 16.0 5.2e-14 52.3 16.0 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 EFC50204.1 - 0.0088 16.0 12.9 0.21 11.6 1.5 2.6 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HicA_toxin PF07927.12 EFC50204.1 - 0.028 14.5 0.0 0.079 13.0 0.0 1.8 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, HypA PF01155.19 EFC50204.1 - 0.029 14.4 6.1 1.5 8.9 0.5 2.6 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 EFC50204.1 - 0.46 10.6 11.0 1.4 9.1 1.7 2.5 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) TackOD1 PF18551.1 EFC50204.1 - 0.62 9.7 7.0 4.2 7.0 0.8 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 Val_tRNA-synt_C PF10458.9 EFC50204.1 - 0.9 9.9 3.3 0.41 11.0 0.3 1.9 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm DUF5351 PF17302.2 EFC50204.1 - 3.5 7.9 19.8 2 8.7 1.8 4.2 4 0 0 4 4 4 0 Family of unknown function (DUF5351) TrmO PF01980.16 EFC50205.1 - 5.2e-41 139.6 0.0 1.4e-40 138.2 0.0 1.8 1 0 0 1 1 1 1 tRNA-methyltransferase O TrmO_C PF18389.1 EFC50205.1 - 9.7e-12 44.8 0.1 1.9e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 TrmO C-terminal domain DUF4116 PF13475.6 EFC50205.1 - 0.00039 20.1 2.3 0.072 12.8 0.2 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4116) Ribonuclease_3 PF00636.26 EFC50206.1 - 5.8e-40 136.2 0.1 9.7e-19 68.0 0.0 3.4 2 0 0 2 2 2 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 EFC50206.1 - 2.2e-28 99.0 1.7 6.9e-15 55.3 0.1 3.5 3 0 0 3 3 3 2 Ribonuclease-III-like Dicer_dimer PF03368.14 EFC50206.1 - 2.2e-16 59.8 0.4 9.2e-16 57.8 0.1 2.3 2 0 0 2 2 2 1 Dicer dimerisation domain PAZ PF02170.22 EFC50206.1 - 1.2e-14 54.3 1.3 3.9e-14 52.6 1.3 1.9 1 0 0 1 1 1 1 PAZ domain Helicase_C PF00271.31 EFC50206.1 - 5.8e-14 52.4 0.1 5.8e-14 52.4 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50206.1 - 4.1e-09 36.7 1.1 4.1e-09 36.7 1.1 3.3 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 EFC50206.1 - 4.2e-08 33.1 3.6 1.7e-07 31.1 1.2 2.9 2 1 0 2 2 2 1 DEAD/DEAH box helicase dsrm PF00035.26 EFC50206.1 - 0.00028 21.5 0.0 0.0014 19.3 0.0 2.3 1 0 0 1 1 1 1 Double-stranded RNA binding motif Afi1 PF07792.12 EFC50206.1 - 0.2 12.2 0.1 0.2 12.2 0.1 2.6 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Pyr_redox_2 PF07992.14 EFC50208.1 - 2.5e-13 49.9 0.1 4.7e-10 39.2 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 EFC50208.1 - 0.00016 21.7 0.1 0.00093 19.2 0.0 2.4 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 EFC50208.1 - 0.00034 20.8 0.0 0.0012 19.0 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 EFC50208.1 - 0.0084 15.4 0.0 0.023 13.9 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain NAD_binding_7 PF13241.6 EFC50208.1 - 0.014 15.8 0.4 3.6 8.1 0.0 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 EFC50208.1 - 0.015 14.0 0.0 0.19 10.4 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 EFC50208.1 - 0.023 15.2 0.0 1.6 9.3 0.0 3.2 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC50208.1 - 0.081 12.5 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 EFC50208.1 - 0.16 10.8 0.0 0.28 10.0 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase dsDNA_bind PF01984.20 EFC50209.1 - 2e-24 86.0 10.9 2e-24 86.0 10.9 1.9 2 0 0 2 2 2 1 Double-stranded DNA-binding domain TPR_2 PF07719.17 EFC50209.1 - 2.3e-22 77.3 16.6 0.00014 21.7 0.0 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50209.1 - 2.7e-20 71.2 25.1 1.5e-05 24.6 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50209.1 - 9.1e-17 59.8 32.9 0.00012 22.0 1.3 8.6 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50209.1 - 6.3e-15 55.4 17.5 7.8e-05 23.1 0.1 7.7 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50209.1 - 9.1e-15 54.7 13.2 0.0011 19.2 0.0 7.3 7 2 1 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50209.1 - 1.9e-13 50.0 0.3 0.29 12.0 0.0 8.4 8 2 2 10 10 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50209.1 - 8.7e-12 45.5 0.3 0.0077 16.9 0.0 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50209.1 - 6.1e-10 38.4 7.0 0.0009 19.1 0.1 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50209.1 - 7.7e-09 35.1 8.8 0.15 11.8 0.0 6.3 5 2 1 6 6 6 3 TPR repeat TPR_17 PF13431.6 EFC50209.1 - 1.8e-08 34.2 4.8 0.023 15.1 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50209.1 - 2e-06 27.5 1.1 0.68 9.9 0.0 5.2 5 0 0 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50209.1 - 3.8e-06 27.0 28.7 0.0015 18.7 1.0 7.2 5 3 1 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFC50209.1 - 3.3e-05 24.2 10.9 0.33 11.7 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC50209.1 - 0.00021 20.7 1.3 2.2 7.8 0.0 4.7 5 1 0 5 5 5 2 SHNi-TPR TPR_20 PF14561.6 EFC50209.1 - 0.0082 16.5 10.0 0.95 9.8 0.0 4.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_21 PF09976.9 EFC50209.1 - 0.0094 15.7 11.4 0.061 13.0 0.3 4.0 3 2 2 5 5 5 2 Tetratricopeptide repeat-like domain DUF223 PF02721.14 EFC50210.1 - 0.018 15.3 0.7 0.073 13.4 0.7 2.2 1 1 0 1 1 1 0 Domain of unknown function DUF223 PB1 PF00564.24 EFC50211.1 - 1.3e-05 25.1 0.6 0.00059 19.7 0.2 2.6 2 1 0 2 2 2 1 PB1 domain vATP-synt_AC39 PF01992.16 EFC50211.1 - 0.0077 15.8 0.9 0.032 13.7 0.2 2.1 2 1 0 2 2 2 1 ATP synthase (C/AC39) subunit A_deaminase PF00962.22 EFC50212.1 - 4.5e-24 85.4 0.0 1.1e-23 84.2 0.0 1.6 1 1 0 1 1 1 1 Adenosine/AMP deaminase Ribosomal_S18 PF01084.20 EFC50213.1 - 8.7e-17 61.1 0.1 2.2e-16 59.8 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein S18 CHCH PF06747.13 EFC50214.1 - 1.1e-05 25.5 7.4 1.1e-05 25.5 7.4 2.1 1 1 1 2 2 2 1 CHCH domain DUF2076 PF09849.9 EFC50214.1 - 0.00015 21.9 11.0 0.00019 21.6 11.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Pet191_N PF10203.9 EFC50214.1 - 0.012 15.9 4.0 0.021 15.1 4.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 EFC50214.1 - 0.015 15.3 7.3 0.028 14.4 7.3 1.5 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 EFC50214.1 - 0.062 13.3 2.8 0.096 12.7 2.8 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like DUF908 PF06012.12 EFC50214.1 - 0.23 10.8 4.1 0.28 10.5 4.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) La PF05383.17 EFC50215.1 - 2.3e-20 72.4 0.3 4.5e-20 71.5 0.3 1.5 1 0 0 1 1 1 1 La domain Coilin_N PF15862.5 EFC50215.1 - 0.0043 16.9 5.9 0.63 9.8 0.0 4.0 4 2 1 5 5 5 1 Coilin N-terminus GRASP55_65 PF04495.14 EFC50216.1 - 5.7e-29 101.2 0.2 1.2e-28 100.2 0.0 1.6 2 0 0 2 2 2 1 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 EFC50216.1 - 0.056 13.3 0.2 1.7 8.6 0.0 2.5 2 1 0 2 2 2 0 PDZ domain Uds1 PF15456.6 EFC50216.1 - 0.086 13.0 0.3 1 9.5 0.0 2.6 3 0 0 3 3 3 0 Up-regulated During Septation ALMT PF11744.8 EFC50216.1 - 0.46 9.3 4.0 0.11 11.3 0.8 1.5 2 0 0 2 2 2 0 Aluminium activated malate transporter PITH PF06201.13 EFC50217.1 - 3.8e-32 111.6 6.1 7.3e-32 110.7 6.1 1.5 1 0 0 1 1 1 1 PITH domain Peptidase_C97 PF05903.14 EFC50217.1 - 4.9e-22 78.4 3.0 5.1e-15 55.6 0.2 2.5 1 1 1 2 2 2 2 PPPDE putative peptidase domain DUF3908 PF13048.6 EFC50217.1 - 0.13 12.5 5.7 0.25 11.6 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3908) RNA_pol_Rpb5_C PF01191.19 EFC50218.1 - 2e-32 110.8 0.6 3.7e-32 110.0 0.6 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 EFC50218.1 - 2.4e-31 108.2 0.0 4.2e-31 107.4 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain TM2 PF05154.16 EFC50219.1 - 9.2e-11 41.9 8.0 1.6e-10 41.1 8.0 1.4 1 0 0 1 1 1 1 TM2 domain Guanylate_cyc PF00211.20 EFC50220.1 - 3.2e-53 180.1 0.0 6.2e-53 179.1 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC50220.1 - 1.2e-11 44.7 1.1 4e-11 43.1 0.4 2.4 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 EFC50220.1 - 4.2e-07 30.0 0.0 1.6e-06 28.1 0.0 2.0 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 EFC50220.1 - 0.0071 16.3 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 PAS domain DUF4368 PF14287.6 EFC50220.1 - 1.1 9.6 3.9 35 4.8 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4368) Helicase_C PF00271.31 EFC50221.1 - 2.7e-35 121.1 0.3 8.1e-34 116.3 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC50221.1 - 9.8e-33 113.4 3.6 2.2e-31 109.0 0.2 2.7 2 1 1 3 3 3 2 DEAD/DEAH box helicase AAA_22 PF13401.6 EFC50221.1 - 0.00023 21.4 0.4 0.00067 19.9 0.4 1.9 1 1 0 1 1 1 1 AAA domain ERCC3_RAD25_C PF16203.5 EFC50221.1 - 0.006 15.8 0.0 0.01 15.0 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SHOCT PF09851.9 EFC50222.1 - 3.2e-09 36.2 1.6 5.1e-09 35.6 1.6 1.3 1 0 0 1 1 1 1 Short C-terminal domain Tox-SHH PF15652.6 EFC50222.1 - 0.0022 18.9 0.1 0.0025 18.7 0.1 1.2 1 0 0 1 1 1 1 HNH/Endo VII superfamily toxin with a SHH signature DUF4387 PF14330.6 EFC50222.1 - 0.09 13.5 0.0 0.12 13.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4387) DMAP_binding PF06464.11 EFC50222.1 - 2.2 9.1 7.1 0.74 10.6 1.4 2.1 1 1 1 2 2 2 0 DMAP1-binding Domain zf-RING_9 PF13901.6 EFC50223.1 - 2e-50 171.7 19.0 2e-50 171.7 19.0 2.4 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon Bromodomain PF00439.25 EFC50223.1 - 1.3e-15 57.2 1.0 5.1e-15 55.3 1.0 2.1 1 0 0 1 1 1 1 Bromodomain C1_1 PF00130.22 EFC50223.1 - 0.0084 16.0 8.3 0.0084 16.0 8.3 2.4 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn-ribbon_8 PF09723.10 EFC50223.1 - 0.22 11.7 5.7 0.17 12.0 0.7 2.7 2 0 0 2 2 2 0 Zinc ribbon domain Nas2_N PF18265.1 EFC50223.1 - 1.4 8.9 9.3 3.4 7.7 1.0 3.4 1 1 2 3 3 3 0 Nas2 N_terminal domain Glyco_hydro_18 PF00704.28 EFC50224.1 - 2e-21 77.0 0.1 2.8e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_H_20C_C PF18088.1 EFC50224.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain DUF1700 PF08006.11 EFC50224.1 - 1 8.9 6.2 0.57 9.7 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) AhpC-TSA PF00578.21 EFC50226.1 - 5.3e-08 32.8 0.2 1.7e-07 31.2 0.1 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 EFC50226.1 - 4.2e-05 23.3 0.0 0.0002 21.1 0.0 2.1 2 0 0 2 2 2 1 Redoxin Lactamase_B_2 PF12706.7 EFC50227.1 - 5.2e-33 114.3 0.0 2.5e-32 112.1 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 EFC50227.1 - 6.6e-13 48.9 0.1 7.6e-12 45.4 0.1 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFC50227.1 - 0.12 12.4 3.7 0.25 11.3 2.8 2.1 2 1 0 2 2 2 0 Metallo-beta-lactamase superfamily DNA_binding_1 PF01035.20 EFC50227.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain RE_Bpu10I PF09549.10 EFC50228.1 - 0.0084 15.7 0.0 0.01 15.5 0.0 1.2 1 0 0 1 1 1 1 Bpu10I restriction endonuclease COPIIcoated_ERV PF07970.12 EFC50229.1 - 3.9e-81 272.1 1.5 5.4e-81 271.7 1.5 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFC50229.1 - 3.4e-29 101.0 1.1 4.8e-29 100.5 0.1 1.8 3 0 0 3 3 3 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Mito_carr PF00153.27 EFC50230.1 - 3.5e-42 142.2 3.5 7.7e-14 51.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein GTP_EFTU PF00009.27 EFC50231.1 - 5.7e-54 182.6 0.1 1.1e-53 181.7 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 EFC50231.1 - 1.3e-39 134.9 0.1 3e-39 133.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 EFC50231.1 - 2.1e-13 50.5 0.1 7.6e-13 48.7 0.1 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 EFC50231.1 - 7.6e-09 35.7 0.5 7.1e-06 26.1 0.0 2.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase NIF3 PF01784.18 EFC50231.1 - 0.0019 17.9 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) Roc PF08477.13 EFC50231.1 - 0.011 15.9 1.0 0.078 13.2 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 EFC50231.1 - 0.016 14.7 0.1 0.048 13.1 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU_D4 PF14578.6 EFC50231.1 - 0.017 15.0 0.6 0.055 13.4 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Ras PF00071.22 EFC50231.1 - 0.062 12.9 0.8 0.15 11.6 0.1 1.9 2 0 0 2 2 2 0 Ras family DUF108 PF01958.18 EFC50232.1 - 4.2e-22 78.3 0.1 8.4e-22 77.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.16 EFC50232.1 - 6e-11 43.0 0.0 1.2e-10 42.0 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 EFC50232.1 - 0.12 12.9 0.0 0.29 11.7 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent WW PF00397.26 EFC50234.1 - 0.0027 17.8 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 WW domain RE_SinI PF09570.10 EFC50234.1 - 0.039 13.2 0.1 0.052 12.8 0.1 1.2 1 0 0 1 1 1 0 SinI restriction endonuclease CHCH PF06747.13 EFC50234.1 - 0.18 11.9 7.2 0.13 12.4 2.3 2.6 2 0 0 2 2 2 0 CHCH domain SapB_1 PF05184.15 EFC50235.1 - 0.93 9.6 3.9 0.38 10.8 1.2 1.8 2 0 0 2 2 2 0 Saposin-like type B, region 1 RPN6_N PF18055.1 EFC50236.1 - 4.2e-37 127.1 3.5 1.3e-36 125.5 3.5 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 EFC50236.1 - 4.1e-18 65.8 0.7 2.2e-17 63.5 0.5 2.3 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 EFC50236.1 - 2e-12 46.6 0.0 8.1e-12 44.7 0.0 2.1 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 EFC50236.1 - 3e-06 27.4 1.3 0.0055 17.0 0.4 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF2153 PF09921.9 EFC50236.1 - 0.0053 16.6 1.3 0.016 15.1 0.3 2.4 2 1 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2153) MIT PF04212.18 EFC50236.1 - 0.012 15.7 3.0 0.19 11.8 0.0 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 EFC50236.1 - 0.13 11.6 0.4 0.31 10.4 0.4 1.6 1 0 0 1 1 1 0 MalT-like TPR region TPR_8 PF13181.6 EFC50236.1 - 0.83 10.0 7.7 25 5.4 0.1 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Spermine_synth PF01564.17 EFC50237.1 - 1.6e-58 197.2 0.0 2.3e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EFC50237.1 - 1.7e-22 79.0 0.1 2.8e-22 78.3 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_12 PF08242.12 EFC50237.1 - 2.3e-05 25.1 0.0 5.6e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC50237.1 - 2.9e-05 24.7 0.1 0.0001 23.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain LRR_5 PF13306.6 EFC50238.1 - 0.0091 16.0 0.1 0.026 14.5 0.1 1.7 1 0 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) Med30 PF11315.8 EFC50238.1 - 0.037 14.2 0.6 0.037 14.2 0.6 4.6 4 0 0 4 4 4 0 Mediator complex subunit 30 SSXT PF05030.12 EFC50238.1 - 0.056 13.1 1.3 0.11 12.2 0.2 2.1 2 0 0 2 2 2 0 SSXT protein (N-terminal region) SNARE PF05739.19 EFC50239.1 - 9.4e-09 35.1 0.1 9.4e-09 35.1 0.1 3.0 4 0 0 4 4 4 1 SNARE domain Syntaxin PF00804.25 EFC50239.1 - 6.1e-06 26.0 12.9 6.1e-06 26.0 12.9 1.4 2 0 0 2 2 2 1 Syntaxin ArlS_N PF18719.1 EFC50239.1 - 0.0064 16.7 10.0 0.0096 16.1 2.8 2.5 1 1 1 2 2 2 1 ArlS sensor domain Prominin PF05478.11 EFC50239.1 - 0.013 13.5 0.5 0.013 13.5 0.5 2.2 2 0 0 2 2 2 0 Prominin DUF3807 PF12720.7 EFC50239.1 - 0.13 12.6 0.4 0.13 12.6 0.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3807) zf-C3HC PF07967.13 EFC50239.1 - 0.15 12.1 0.9 0.59 10.2 0.0 2.2 2 0 0 2 2 2 0 C3HC zinc finger-like Syntaxin_2 PF14523.6 EFC50239.1 - 0.19 12.1 16.0 0.09 13.2 9.0 2.4 2 0 0 2 2 2 0 Syntaxin-like protein CPSase_L_D3 PF02787.19 EFC50239.1 - 0.28 11.5 3.4 0.21 11.9 1.0 2.0 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Ribosomal_L12_N PF16320.5 EFC50239.1 - 1.1 9.0 3.3 5.3 6.8 0.1 2.8 3 0 0 3 3 3 0 Ribosomal protein L7/L12 dimerisation domain DASH_Dad4 PF08650.10 EFC50239.1 - 1.2 9.2 5.3 1.8 8.6 0.0 3.4 3 1 1 4 4 4 0 DASH complex subunit Dad4 LURAP PF14854.6 EFC50240.1 - 0.015 15.2 0.0 0.055 13.4 0.0 2.0 1 0 0 1 1 1 0 Leucine rich adaptor protein MbeD_MobD PF04899.12 EFC50240.1 - 0.29 11.3 0.1 0.29 11.3 0.1 3.4 3 1 0 3 3 3 0 MbeD/MobD like RasGEF PF00617.19 EFC50241.1 - 1.2e-45 155.8 0.2 2.1e-45 155.1 0.2 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 EFC50241.1 - 1.3e-16 60.7 1.1 1.3e-16 60.7 1.1 2.5 2 1 0 3 3 3 1 RasGEF N-terminal motif zf-CpG_bind_C PF12269.8 EFC50241.1 - 0.086 12.6 0.1 0.086 12.6 0.1 1.8 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain DUF1542 PF07564.11 EFC50242.1 - 0.042 14.0 0.4 0.042 14.0 0.4 2.8 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1542) FTCD_C PF04961.12 EFC50242.1 - 0.062 13.1 2.5 0.15 11.9 2.5 1.7 1 1 0 1 1 1 0 Formiminotransferase-cyclodeaminase HeLo PF14479.6 EFC50242.1 - 0.16 11.8 10.7 0.039 13.8 7.0 1.9 1 1 1 2 2 2 0 Prion-inhibition and propagation SIT PF15330.6 EFC50242.1 - 3.6 8.1 8.0 0.66 10.4 0.3 2.6 2 1 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT LRR_8 PF13855.6 EFC50243.1 - 2.4e-08 33.6 10.2 0.00064 19.4 3.5 4.1 1 1 3 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 EFC50243.1 - 1.9e-05 24.9 12.6 0.00027 21.2 3.5 4.4 2 1 3 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 EFC50243.1 - 0.002 18.0 9.7 0.56 10.4 0.2 4.5 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 EFC50243.1 - 0.061 13.9 1.0 0.061 13.9 1.0 5.9 6 1 0 6 6 6 0 Leucine Rich Repeat Slu7 PF11708.8 EFC50244.1 - 8.5e-77 258.5 23.6 8.5e-77 258.5 23.6 1.8 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 EFC50244.1 - 0.084 12.6 1.3 0.17 11.7 0.6 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 EFC50244.1 - 0.27 11.4 2.7 0.54 10.4 2.7 1.5 1 0 0 1 1 1 0 Zinc knuckle DUF3043 PF11241.8 EFC50244.1 - 4.3 7.3 8.3 15 5.6 8.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Glutaminase PF04960.15 EFC50245.1 - 2.4e-116 387.9 0.0 2.8e-116 387.7 0.0 1.0 1 0 0 1 1 1 1 Glutaminase EF-hand_14 PF17959.1 EFC50245.1 - 0.045 14.1 0.0 0.083 13.2 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Peptidase_M14 PF00246.24 EFC50246.1 - 3.2e-62 211.0 0.1 4.2e-62 210.6 0.1 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase CarboxypepD_reg PF13620.6 EFC50246.1 - 4.4e-11 42.9 0.1 7.5e-11 42.1 0.1 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 EFC50246.1 - 2.6e-07 30.5 0.1 4.9e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 CarboxypepD_reg-like domain DUF2817 PF10994.8 EFC50246.1 - 0.00013 21.5 0.1 0.00019 20.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2817) AstE_AspA PF04952.14 EFC50246.1 - 0.00024 20.3 0.1 0.00064 18.9 0.1 1.6 1 1 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family DUF2846 PF11008.8 EFC50246.1 - 0.0011 18.9 0.1 0.0088 16.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2846) PEGA PF08308.11 EFC50246.1 - 0.012 15.5 0.0 0.033 14.1 0.0 1.8 1 0 0 1 1 1 0 PEGA domain Y_Y_Y PF07495.13 EFC50246.1 - 0.069 13.1 0.1 0.17 11.9 0.1 1.6 1 0 0 1 1 1 0 Y_Y_Y domain Pkinase PF00069.25 EFC50247.1 - 4e-66 223.1 0.1 4e-66 223.1 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50247.1 - 6.1e-41 140.4 1.0 7.6e-41 140.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC50247.1 - 1e-08 34.6 0.2 1e-08 34.6 0.2 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 EFC50247.1 - 8.4e-07 28.6 0.0 1.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like DUF3552 PF12072.8 EFC50247.1 - 0.00029 20.3 11.0 0.00051 19.5 11.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) DUF1168 PF06658.12 EFC50247.1 - 1.4 8.8 15.4 2.4 8.0 15.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) FTA2 PF13095.6 EFC50247.1 - 1.4 8.5 7.2 7.6 6.1 2.0 3.0 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Brix PF04427.18 EFC50248.1 - 8.8e-23 81.4 2.2 1.1e-22 81.1 2.2 1.1 1 0 0 1 1 1 1 Brix domain Diphthamide_syn PF01866.17 EFC50248.1 - 0.054 12.9 0.1 0.075 12.5 0.1 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein Complex1_LYR PF05347.15 EFC50249.1 - 2.8e-19 68.9 0.7 3.6e-19 68.6 0.1 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 EFC50249.1 - 0.00014 22.5 0.8 0.00017 22.3 0.8 1.3 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 EFC50249.1 - 0.00067 20.2 0.0 0.00086 19.9 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like SH3_1 PF00018.28 EFC50250.1 - 5.6e-08 32.3 0.0 9.8e-08 31.5 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 EFC50250.1 - 2.2e-06 27.4 0.0 3.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 EFC50250.1 - 0.00014 21.4 0.0 0.00025 20.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Osmo_CC PF08946.10 EFC50250.1 - 0.011 16.0 1.5 0.032 14.5 1.5 1.9 1 0 0 1 1 1 0 Osmosensory transporter coiled coil CENP-H PF05837.12 EFC50250.1 - 0.011 16.1 2.5 0.011 16.1 2.5 2.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) MCPsignal PF00015.21 EFC50250.1 - 0.012 15.5 0.7 0.012 15.5 0.7 2.4 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF4083 PF13314.6 EFC50250.1 - 0.35 10.8 1.2 6.9 6.7 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) FlaC_arch PF05377.11 EFC50250.1 - 0.43 11.0 7.7 0.35 11.3 0.7 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF573 PF04504.14 EFC50250.1 - 3.8 8.2 7.7 0.21 12.3 0.8 2.4 2 1 0 2 2 2 0 Protein of unknown function, DUF573 XhlA PF10779.9 EFC50250.1 - 3.9 7.8 10.4 12 6.2 1.9 3.3 2 1 1 3 3 3 0 Haemolysin XhlA Jnk-SapK_ap_N PF09744.9 EFC50250.1 - 3.9 7.7 17.7 0.72 10.1 3.5 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Nop10p PF04135.12 EFC50251.1 - 3.1e-20 72.0 5.7 4.3e-20 71.5 5.7 1.2 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Sld5 PF05916.11 EFC50252.1 - 0.0012 19.3 0.2 0.0033 17.9 0.0 1.9 2 0 0 2 2 2 1 GINS complex protein EP400_N PF15790.5 EFC50253.1 - 0.031 13.1 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal Med25 PF11232.8 EFC50253.1 - 0.053 13.5 0.3 0.29 11.1 0.0 2.3 2 0 0 2 2 2 0 Mediator complex subunit 25 PTOV activation and synapsin 2 Ssl1 PF04056.14 EFC50254.1 - 1.1e-63 214.6 0.1 1.3e-63 214.3 0.1 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 EFC50254.1 - 8.2e-14 51.6 12.8 8.2e-14 51.6 12.8 3.5 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 EFC50254.1 - 7.6e-08 33.0 0.0 1.6e-07 31.9 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain Tfb4 PF03850.14 EFC50254.1 - 5e-07 29.5 2.7 1.1e-06 28.3 2.7 1.6 1 0 0 1 1 1 1 Transcription factor Tfb4 IBR PF01485.21 EFC50254.1 - 0.0053 17.0 6.9 0.0053 17.0 6.9 3.3 2 1 0 2 2 2 1 IBR domain, a half RING-finger domain DZR PF12773.7 EFC50254.1 - 0.067 13.2 23.8 1.2 9.2 5.6 3.1 2 1 0 2 2 2 0 Double zinc ribbon zf-AN1 PF01428.16 EFC50254.1 - 2.7 8.2 29.8 2.2 8.5 4.9 3.7 2 1 1 3 3 3 0 AN1-like Zinc finger Stc1 PF12898.7 EFC50254.1 - 10 6.8 11.4 1.6 9.3 2.1 2.6 2 0 0 2 2 2 0 Stc1 domain L51_S25_CI-B8 PF05047.16 EFC50255.1 - 6e-11 42.1 0.1 1.3e-10 41.0 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Arm-DNA-bind_5 PF17293.2 EFC50255.1 - 0.03 14.8 0.1 0.039 14.4 0.1 1.2 1 0 0 1 1 1 0 Arm DNA-binding domain MMR_HSR1 PF01926.23 EFC50256.1 - 3.5e-13 49.6 2.4 4.3e-12 46.1 0.1 3.0 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC50256.1 - 2.7e-06 27.4 0.8 1.2e-05 25.3 0.6 2.2 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 EFC50256.1 - 0.0012 19.0 1.1 0.046 13.9 0.1 3.1 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 EFC50256.1 - 0.0015 18.1 0.2 0.015 14.8 0.1 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_22 PF13401.6 EFC50256.1 - 0.006 16.8 0.2 0.028 14.7 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 EFC50256.1 - 0.019 15.0 0.1 0.1 12.6 0.1 2.3 1 0 0 1 1 1 0 AAA domain Ras PF00071.22 EFC50256.1 - 0.019 14.6 0.4 1.4 8.4 0.1 2.6 2 0 0 2 2 2 0 Ras family Rpr2 PF04032.16 EFC50256.1 - 0.025 14.8 0.2 0.17 12.2 0.0 2.4 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Dynamin_N PF00350.23 EFC50256.1 - 0.025 14.6 0.1 0.025 14.6 0.1 4.3 2 2 2 4 4 4 0 Dynamin family GTP_EFTU PF00009.27 EFC50256.1 - 0.072 12.6 5.8 2.6 7.5 0.0 2.9 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain YopX PF09643.10 EFC50256.1 - 0.11 12.5 4.2 0.5 10.4 4.2 2.1 1 1 0 1 1 1 0 YopX protein TF_Zn_Ribbon PF08271.12 EFC50256.1 - 0.12 11.9 0.1 24 4.6 0.0 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zf_UBZ PF18439.1 EFC50256.1 - 0.44 10.2 2.3 4.3 7.0 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger CpXC PF14353.6 EFC50256.1 - 0.5 10.4 2.8 1.8 8.6 0.0 2.9 2 1 0 2 2 2 0 CpXC protein Cullin_Nedd8 PF10557.9 EFC50257.1 - 6.2e-24 83.8 1.9 1.7e-23 82.4 1.9 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.22 EFC50257.1 - 1.5e-17 63.5 1.9 3.1e-17 62.4 0.1 1.9 2 0 0 2 2 2 1 Cullin family YmgB PF10798.8 EFC50257.1 - 0.026 14.4 0.3 0.055 13.3 0.3 1.6 1 0 0 1 1 1 0 Biofilm development protein YmgB/AriR DUF1803 PF08820.10 EFC50257.1 - 0.044 13.8 2.5 0.22 11.6 0.1 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF1803) Peripla_BP_6 PF13458.6 EFC50258.1 - 2e-25 90.2 0.0 1.3e-17 64.6 0.0 2.9 3 0 0 3 3 3 2 Periplasmic binding protein Guanylate_cyc PF00211.20 EFC50258.1 - 0.015 14.9 0.1 0.041 13.5 0.1 1.6 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain POTRA_3 PF17287.2 EFC50258.1 - 0.12 11.9 0.2 7.8 6.0 0.1 2.6 2 0 0 2 2 2 0 POTRA domain CRISPR_Cas2 PF09827.9 EFC50258.1 - 0.15 12.2 1.1 34 4.7 0.0 3.2 3 0 0 3 3 3 0 CRISPR associated protein Cas2 DUF4834 PF16118.5 EFC50258.1 - 0.18 12.8 2.1 0.46 11.5 2.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Baculo_11_kDa PF06143.11 EFC50258.1 - 0.22 11.1 3.3 0.79 9.3 3.3 1.9 1 0 0 1 1 1 0 Baculovirus 11 kDa family UPF0560 PF10577.9 EFC50258.1 - 5 5.5 6.1 7.3 5.0 6.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Guanylate_cyc PF00211.20 EFC50259.1 - 4.6e-21 75.3 0.1 6.2e-21 74.8 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain XRCC1_N PF01834.16 EFC50260.1 - 3.4e-05 23.9 0.0 1.8 8.6 0.0 3.4 2 1 1 3 3 3 3 XRCC1 N terminal domain RNA_pol_A_bac PF01000.26 EFC50261.1 - 4e-27 94.8 0.0 1e-26 93.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 EFC50261.1 - 1e-20 72.9 0.0 1.5e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Fer4_7 PF12838.7 EFC50261.1 - 0.019 15.5 1.9 0.048 14.3 1.9 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 EFC50261.1 - 0.023 14.8 2.3 0.048 13.8 1.2 2.1 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 EFC50261.1 - 0.09 12.9 1.0 0.21 11.8 1.0 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Ipi1_N PF12333.8 EFC50262.1 - 6.2e-10 39.6 3.5 3.8e-09 37.1 0.5 3.8 2 1 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation TetR_C_19 PF17924.1 EFC50262.1 - 3 8.4 13.3 0.37 11.4 1.2 3.7 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Xpo1 PF08389.12 EFC50263.1 - 8.5e-15 55.1 0.8 8.5e-15 55.1 0.8 4.4 5 1 0 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 EFC50263.1 - 0.014 15.3 5.0 0.02 14.8 0.2 3.6 2 1 1 3 3 3 0 Importin-beta N-terminal domain GLYCAM-1 PF05242.11 EFC50263.1 - 0.077 13.1 0.9 0.26 11.4 0.2 2.3 2 0 0 2 2 2 0 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1) Dot_icm_IcmQ PF09475.10 EFC50263.1 - 0.083 12.4 0.2 0.23 10.9 0.2 1.7 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) RNA_binding PF01877.17 EFC50263.1 - 0.18 12.1 1.3 0.83 9.9 0.2 2.7 2 0 0 2 2 2 0 RNA binding cNMP_binding PF00027.29 EFC50264.1 - 6e-17 61.5 0.0 1.2e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 EFC50264.1 - 4.4e-07 29.4 11.4 6e-07 28.9 11.4 1.2 1 0 0 1 1 1 1 Ion transport protein vATP-synt_AC39 PF01992.16 EFC50264.1 - 0.24 10.9 2.0 0.37 10.3 0.5 1.9 2 0 0 2 2 2 0 ATP synthase (C/AC39) subunit Ion_trans_2 PF07885.16 EFC50264.1 - 0.28 11.2 13.9 1.1 9.3 13.9 2.1 1 1 0 1 1 1 0 Ion channel Cas_Csn2 PF09711.10 EFC50264.1 - 0.29 10.8 5.9 0.066 12.9 1.2 2.0 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csn2) ATG16 PF08614.11 EFC50265.1 - 0.00036 20.8 27.3 0.00036 20.8 27.3 8.5 1 1 6 8 8 8 3 Autophagy protein 16 (ATG16) ParcG PF10274.9 EFC50266.1 - 1.6e-81 272.8 0.2 2e-81 272.5 0.2 1.1 1 0 0 1 1 1 1 Parkin co-regulated protein Ras PF00071.22 EFC50267.1 - 1.6e-47 161.1 0.4 2.3e-47 160.6 0.4 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50267.1 - 2.9e-16 59.8 0.0 5e-16 59.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 EFC50267.1 - 2.3e-09 37.1 0.2 6.8e-09 35.5 0.1 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC50267.1 - 1.4e-08 34.4 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 EFC50267.1 - 9.1e-06 25.7 0.1 7.5e-05 22.7 0.1 2.1 1 1 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 EFC50267.1 - 0.00013 22.0 0.1 0.00013 22.0 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC50267.1 - 0.0013 18.2 0.8 0.0027 17.2 0.1 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 EFC50267.1 - 0.0013 18.2 0.1 0.0023 17.5 0.1 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1_Xtn PF16897.5 EFC50267.1 - 0.0046 16.9 0.1 0.036 14.1 0.1 2.3 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TPP_enzyme_M PF00205.22 EFC50267.1 - 0.047 13.4 0.0 0.075 12.8 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain PCI PF01399.27 EFC50268.1 - 1.6e-11 44.6 4.7 2.3e-11 44.1 0.9 3.0 2 0 0 2 2 2 1 PCI domain DUF1077 PF06417.12 EFC50269.1 - 4.9e-28 97.5 3.5 5.3e-28 97.4 3.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Gtr1_RagA PF04670.12 EFC50270.1 - 7.4e-105 349.4 1.6 1e-104 348.9 1.6 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 EFC50270.1 - 5.1e-10 39.6 1.2 1.2e-09 38.4 0.0 2.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50270.1 - 1.3e-09 37.7 0.2 2.2e-09 37.0 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 EFC50270.1 - 2.7e-09 36.8 0.6 4.7e-09 36.1 0.1 1.7 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 EFC50270.1 - 4.5e-07 29.9 0.0 8.9e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC50270.1 - 1.7e-05 24.3 0.1 2.9e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Pro_sub2 PF18513.1 EFC50270.1 - 0.014 15.5 0.2 0.24 11.6 0.0 2.7 2 0 0 2 2 2 0 Prodomain subtilisin 2 RsgA_GTPase PF03193.16 EFC50270.1 - 0.015 15.2 1.6 4.4 7.2 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase PduV-EutP PF10662.9 EFC50270.1 - 0.019 14.7 0.1 0.081 12.7 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 EFC50270.1 - 0.022 15.2 0.5 0.047 14.2 0.2 1.9 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.13 EFC50270.1 - 0.034 13.3 0.4 0.077 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 EFC50270.1 - 0.075 12.8 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 EFC50270.1 - 3.5 6.7 11.2 1.4 8.0 0.1 3.1 1 1 1 3 3 3 0 G-protein alpha subunit NHL PF01436.21 EFC50272.1 - 1.9e-05 24.5 0.0 0.011 15.7 0.0 3.6 4 0 0 4 4 4 2 NHL repeat Nipped-B_C PF12830.7 EFC50273.1 - 8.9e-14 51.9 1.9 4.9e-13 49.5 0.1 3.3 3 1 1 4 4 4 1 Sister chromatid cohesion C-terminus HEAT_2 PF13646.6 EFC50273.1 - 1.3e-08 35.1 0.4 1.5 9.3 0.0 5.2 6 0 0 6 6 6 2 HEAT repeats HEAT PF02985.22 EFC50273.1 - 1.8e-07 30.8 1.1 1.4 9.3 0.0 6.6 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 EFC50273.1 - 6.6e-06 26.3 21.4 2.3e-05 24.5 2.9 4.9 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 EFC50273.1 - 0.0018 18.6 3.8 0.0038 17.5 0.1 3.3 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion RTP1_C1 PF10363.9 EFC50273.1 - 0.0029 17.8 0.2 0.018 15.2 0.2 2.5 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 RasGEF_N_2 PF14663.6 EFC50273.1 - 0.0042 17.5 4.9 0.83 10.1 0.0 4.5 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain Lipase_bact_N PF12262.8 EFC50273.1 - 0.063 12.6 1.0 0.11 11.8 0.1 2.0 2 0 0 2 2 2 0 Bacterial virulence factor lipase N-terminal HEAT_EZ PF13513.6 EFC50273.1 - 0.097 13.2 0.0 1.5e+02 3.1 0.0 4.6 5 0 0 5 5 5 0 HEAT-like repeat MBA1 PF07961.11 EFC50274.1 - 4.5e-08 32.5 2.5 5.7e-08 32.1 2.5 1.1 1 0 0 1 1 1 1 MBA1-like protein Tim44 PF04280.15 EFC50274.1 - 6.5e-08 32.8 0.2 9.2e-08 32.3 0.2 1.2 1 0 0 1 1 1 1 Tim44-like domain TFIID_NTD2 PF04494.15 EFC50274.1 - 0.055 13.7 2.0 0.1 12.8 1.6 1.7 1 1 1 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain SRI PF08236.11 EFC50274.1 - 0.06 13.5 1.8 0.16 12.2 1.8 1.7 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain P22_AR_C PF10548.9 EFC50274.1 - 0.14 12.3 0.1 1.1 9.5 0.1 2.5 2 1 0 2 2 2 0 P22AR C-terminal domain Herpes_pp38 PF04846.13 EFC50275.1 - 0.094 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein Proteasome PF00227.26 EFC50276.1 - 1.3e-44 152.0 0.1 1.5e-44 151.8 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit TPALS PF18178.1 EFC50277.1 - 0.069 12.6 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 TIR- and PNP-associating SLOG family PPL5 PF18168.1 EFC50277.1 - 1 8.6 8.8 2.1 7.6 1.6 2.5 2 1 0 2 2 2 0 Prim-pol family 5 KH_8 PF17903.1 EFC50278.1 - 5.2e-33 113.0 0.0 5.2e-33 113.0 0.0 2.5 3 0 0 3 3 3 1 Krr1 KH1 domain KH_1 PF00013.29 EFC50278.1 - 0.00022 21.0 0.0 0.00047 19.9 0.0 1.5 1 0 0 1 1 1 1 KH domain Arena_ncap_C PF17290.2 EFC50278.1 - 0.012 15.0 3.1 0.029 13.7 2.0 2.0 1 1 1 2 2 2 0 Arenavirus nucleocapsid C-terminal domain KH_4 PF13083.6 EFC50278.1 - 0.084 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 KH domain Sec1 PF00995.23 EFC50279.1 - 7e-129 431.7 15.6 8.4e-129 431.4 15.6 1.1 1 0 0 1 1 1 1 Sec1 family TOPRIM_C PF16898.5 EFC50279.1 - 0.86 9.9 7.5 0.15 12.3 3.2 2.0 2 0 0 2 2 2 0 C-terminal associated domain of TOPRIM Rho_Binding PF08912.11 EFC50279.1 - 6.3 7.7 8.2 25 5.8 1.4 3.8 2 1 1 3 3 3 0 Rho Binding BSD PF03909.17 EFC50280.1 - 5.6e-08 32.7 3.9 1.5e-05 24.9 0.4 3.3 3 0 0 3 3 3 2 BSD domain DUF3834 PF12916.7 EFC50280.1 - 0.055 12.7 0.2 0.11 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) PAPS_reduct PF01507.19 EFC50280.1 - 0.18 11.8 3.2 5.8 6.9 0.8 3.7 3 1 0 3 3 3 0 Phosphoadenosine phosphosulfate reductase family COPIIcoated_ERV PF07970.12 EFC50280.1 - 0.77 9.6 3.6 0.87 9.4 0.4 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum vesicle transporter Arginase PF00491.21 EFC50281.1 - 6.4e-42 144.0 0.0 7.2e-42 143.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family Acyl-CoA_dh_1 PF00441.24 EFC50282.1 - 3.2e-42 144.3 0.0 5.5e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 EFC50282.1 - 1.2e-36 125.8 0.0 2.1e-36 125.0 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 EFC50282.1 - 3.4e-26 91.3 0.1 7e-26 90.3 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 EFC50282.1 - 2.7e-16 60.1 0.0 5.7e-16 59.0 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Transmemb_17 PF09799.9 EFC50283.1 - 4e-18 65.9 1.0 4e-18 65.9 1.0 2.7 3 0 0 3 3 3 1 Predicted membrane protein Xpo1 PF08389.12 EFC50283.1 - 3.7e-14 53.0 1.0 3.7e-14 53.0 1.0 4.4 4 1 0 4 4 4 1 Exportin 1-like protein CBF PF03914.17 EFC50283.1 - 0.069 13.2 0.1 0.25 11.3 0.1 2.0 1 0 0 1 1 1 0 CBF/Mak21 family Spt20 PF12090.8 EFC50284.1 - 4.7e-10 39.5 0.7 4.7e-10 39.5 0.7 4.9 3 2 1 5 5 5 1 Spt20 family CreD PF06123.12 EFC50284.1 - 0.5 9.1 2.8 0.94 8.2 2.8 1.3 1 0 0 1 1 1 0 Inner membrane protein CreD CC2D2AN-C2 PF15625.6 EFC50285.1 - 5.4e-43 146.7 1.0 1.1e-42 145.7 1.0 1.5 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain MORN_2 PF07661.13 EFC50285.1 - 0.06 13.6 0.7 0.73 10.2 0.0 3.1 3 0 0 3 3 3 0 MORN repeat variant Uteroglobin PF01099.17 EFC50285.1 - 1.5 9.2 6.3 1.5 9.2 0.1 3.3 3 0 0 3 3 3 0 Uteroglobin family DUF4298 PF14131.6 EFC50285.1 - 5.4 7.1 11.7 0.033 14.1 0.8 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) DSPc PF00782.20 EFC50286.1 - 5.1e-34 116.9 0.2 5.9e-34 116.7 0.2 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 EFC50286.1 - 0.00034 20.3 0.5 0.00068 19.3 0.2 1.5 1 1 1 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC50286.1 - 0.018 14.7 0.4 0.025 14.2 0.4 1.4 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Init_tRNA_PT PF04179.12 EFC50286.1 - 0.097 13.0 0.1 0.23 11.8 0.1 1.6 2 0 0 2 2 2 0 Rit1 DUSP-like domain DUF732 PF05305.14 EFC50286.1 - 0.1 13.0 0.1 0.23 11.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF732) PTPlike_phytase PF14566.6 EFC50286.1 - 0.11 12.6 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate LRR_6 PF13516.6 EFC50288.1 - 5e-09 35.5 4.2 0.042 13.9 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich repeat zf-RING_UBOX PF13445.6 EFC50288.1 - 9.5e-05 22.3 6.0 0.00021 21.2 6.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 EFC50288.1 - 0.00011 22.4 9.0 0.00024 21.4 9.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 EFC50288.1 - 0.00011 22.0 9.5 0.00024 20.9 9.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 EFC50288.1 - 0.00028 21.1 0.0 0.00028 21.1 0.0 3.5 2 1 1 3 3 2 1 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 EFC50288.1 - 0.009 16.0 9.3 0.016 15.1 9.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Allexi_40kDa PF05549.11 EFC50288.1 - 0.0093 15.5 0.7 0.023 14.2 0.7 1.6 1 0 0 1 1 1 1 Allexivirus 40kDa protein zf-C3HC4_4 PF15227.6 EFC50288.1 - 0.019 15.1 6.4 0.048 13.8 6.4 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 EFC50288.1 - 0.42 10.4 7.0 1 9.1 7.0 1.7 1 0 0 1 1 1 0 RING-like zinc finger LRR_1 PF00560.33 EFC50288.1 - 0.46 11.2 2.0 23 6.1 0.0 4.0 3 0 0 3 3 2 0 Leucine Rich Repeat zf-ANAPC11 PF12861.7 EFC50288.1 - 1.1 9.3 6.7 0.33 11.0 3.3 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 EFC50288.1 - 1.8 8.4 11.6 3.8 7.4 11.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 EFC50288.1 - 3.8 7.4 10.9 11 6.0 10.9 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SET PF00856.28 EFC50289.1 - 1.1e-06 29.1 0.5 4e-06 27.3 0.3 2.0 1 1 0 1 1 1 1 SET domain Ten1_2 PF15490.6 EFC50291.1 - 0.0091 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 Telomere-capping, CST complex subunit KH_8 PF17903.1 EFC50293.1 - 5.7 7.1 7.7 23 5.2 0.1 4.2 3 2 0 3 3 3 0 Krr1 KH1 domain Sel1 PF08238.12 EFC50294.1 - 5.8e-31 106.2 23.7 3.1e-05 24.5 0.2 10.6 10 1 1 11 11 11 9 Sel1 repeat TPR_6 PF13174.6 EFC50294.1 - 0.014 16.0 0.1 21 6.0 0.0 4.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50294.1 - 3.7 7.8 7.6 14 6.0 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50294.1 - 6.8 7.2 14.4 5.3 7.5 0.3 6.0 6 0 0 6 6 6 0 Tetratricopeptide repeat E1-E2_ATPase PF00122.20 EFC50295.1 - 4e-23 81.9 0.1 4e-23 81.9 0.1 2.6 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 EFC50295.1 - 7.5e-17 62.3 0.1 6.9e-08 33.0 0.1 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC50295.1 - 1.1e-07 31.9 0.0 2.7e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 EFC50295.1 - 2.3e-05 24.2 5.5 0.047 13.4 0.1 3.2 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 EFC50295.1 - 0.0064 16.1 0.0 0.0064 16.1 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus S6PP PF05116.13 EFC50295.1 - 0.081 12.4 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase DNMT1-RFD PF12047.8 EFC50296.1 - 8.7e-05 22.6 0.2 8.7e-05 22.6 0.2 2.5 2 2 0 2 2 2 1 Cytosine specific DNA methyltransferase replication foci domain Coilin_N PF15862.5 EFC50296.1 - 0.19 11.5 8.8 0.31 10.8 8.8 1.4 1 0 0 1 1 1 0 Coilin N-terminus CDC45 PF02724.14 EFC50296.1 - 0.42 8.8 10.4 0.58 8.4 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Ras PF00071.22 EFC50297.1 - 4e-49 166.3 0.3 4.8e-49 166.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50297.1 - 3.9e-16 59.4 0.1 1.1e-15 57.9 0.0 1.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50297.1 - 2e-11 43.6 0.1 2.6e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC50297.1 - 0.0006 19.9 0.1 0.00097 19.2 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC50297.1 - 0.0023 17.9 2.6 1.1 9.1 0.3 2.8 1 1 2 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 EFC50297.1 - 0.04 13.5 0.2 0.21 11.1 0.2 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain FtsK_SpoIIIE PF01580.18 EFC50297.1 - 0.07 12.5 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family CbiA PF01656.23 EFC50297.1 - 0.12 12.4 3.1 2.2 8.3 3.1 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 EFC50297.1 - 0.17 12.2 0.2 0.33 11.3 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain COQ7 PF03232.13 EFC50298.1 - 1.3e-55 187.8 0.2 1.7e-55 187.4 0.2 1.2 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 MAGE PF01454.19 EFC50298.1 - 0.0017 18.1 0.1 0.0026 17.5 0.1 1.3 1 0 0 1 1 1 1 MAGE family Lin0512_fam PF09585.10 EFC50298.1 - 0.026 14.6 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein (Lin0512_fam) Coat_F PF07875.12 EFC50298.1 - 0.039 14.2 1.2 4.3 7.6 0.1 2.6 2 0 0 2 2 2 0 Coat F domain DUF2157 PF09925.9 EFC50298.1 - 0.21 11.4 0.0 7.7 6.3 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) WD40 PF00400.32 EFC50299.1 - 1.7e-18 66.6 12.7 1.8e-05 25.4 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50299.1 - 2.6e-11 43.7 1.5 0.032 14.5 0.0 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC50299.1 - 0.0011 18.8 0.8 0.0083 16.0 0.4 2.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 EFC50299.1 - 0.002 17.2 3.9 1 8.3 0.2 4.0 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 EFC50299.1 - 0.066 12.9 4.6 0.39 10.4 0.1 3.9 4 1 0 4 4 4 0 TUP1-like enhancer of split Ras PF00071.22 EFC50300.1 - 1.2e-37 129.0 0.4 1.6e-37 128.6 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50300.1 - 5.3e-22 78.3 0.4 1.7e-21 76.7 0.4 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50300.1 - 3.1e-06 26.7 0.1 5.4e-06 26.0 0.1 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC50300.1 - 8.8e-06 25.3 0.0 1.5e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 EFC50300.1 - 0.00017 20.9 2.2 0.15 11.2 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit PduV-EutP PF10662.9 EFC50300.1 - 0.00094 18.9 0.3 0.0061 16.3 0.1 2.2 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 EFC50300.1 - 0.0011 18.3 0.2 0.0019 17.6 0.0 1.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1_Xtn PF16897.5 EFC50300.1 - 0.0043 17.1 0.1 0.012 15.6 0.1 1.7 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain AAA_7 PF12775.7 EFC50300.1 - 0.0055 16.3 0.0 0.0098 15.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region MMR_HSR1 PF01926.23 EFC50300.1 - 0.0068 16.5 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC50300.1 - 0.017 14.7 0.9 0.28 10.7 0.6 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain TniB PF05621.11 EFC50300.1 - 0.045 13.2 0.0 0.093 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 EFC50300.1 - 0.12 11.9 0.1 4.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B TPR_1 PF00515.28 EFC50301.1 - 3.8e-16 58.1 2.9 0.00013 21.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50301.1 - 3e-12 46.6 4.5 0.0024 18.1 0.0 5.6 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50301.1 - 7.1e-11 41.4 6.3 0.012 15.6 0.0 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50301.1 - 1.3e-07 31.3 4.3 0.025 14.4 0.0 4.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50301.1 - 2.7e-07 30.3 5.7 0.042 14.1 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50301.1 - 3.2e-06 26.8 0.8 0.018 15.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat BioT2 PF15368.6 EFC50301.1 - 0.016 15.2 0.5 0.042 13.8 0.5 1.7 1 0 0 1 1 1 0 Spermatogenesis family BioT2 TPR_17 PF13431.6 EFC50301.1 - 0.055 13.9 2.4 87 3.8 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50301.1 - 0.072 12.8 0.3 1.8 8.3 0.0 2.9 2 0 0 2 2 2 0 TPR repeat Mito_carr PF00153.27 EFC50303.1 - 5.2e-62 205.8 4.9 5.9e-25 87.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFC50303.1 - 0.043 13.0 0.6 4.3 6.4 0.0 2.7 3 0 0 3 3 3 0 Gammaproteobacterial serine protease UcrQ PF02939.16 EFC50303.1 - 0.1 12.6 0.1 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 UcrQ family ATG16 PF08614.11 EFC50304.1 - 0.0069 16.6 21.0 0.27 11.4 4.5 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) BST2 PF16716.5 EFC50304.1 - 0.0073 16.9 14.9 0.67 10.6 3.7 3.3 3 0 0 3 3 3 2 Bone marrow stromal antigen 2 Laminin_II PF06009.12 EFC50304.1 - 0.037 14.0 12.5 0.13 12.3 1.5 2.1 1 1 1 2 2 2 0 Laminin Domain II Prefoldin PF02996.17 EFC50304.1 - 0.044 13.7 2.0 0.044 13.7 2.0 2.8 2 1 1 3 3 3 0 Prefoldin subunit Fez1 PF06818.15 EFC50304.1 - 0.18 12.3 22.4 0.64 10.5 7.5 2.1 1 1 1 2 2 2 0 Fez1 WEMBL PF05701.11 EFC50304.1 - 0.2 10.3 21.2 3.1 6.4 20.6 2.0 1 1 0 1 1 1 0 Weak chloroplast movement under blue light ERM PF00769.19 EFC50304.1 - 0.38 10.5 21.5 0.5 10.2 17.6 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF1664 PF07889.12 EFC50304.1 - 0.62 10.1 12.4 0.19 11.7 0.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 EFC50304.1 - 0.65 10.1 23.6 0.27 11.3 4.2 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 EFC50304.1 - 0.69 10.0 20.9 0.18 11.8 4.9 2.3 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 EFC50304.1 - 0.85 8.4 23.3 0.13 11.1 2.4 2.3 1 1 0 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 EFC50304.1 - 0.89 9.6 20.0 54 3.8 17.0 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 EFC50304.1 - 0.94 8.8 11.2 3.7 6.8 10.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 EFC50304.1 - 3.2 6.6 12.4 3.9 6.3 12.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 EFC50304.1 - 3.7 8.3 18.8 2.8 8.6 6.8 2.8 1 1 1 2 2 2 0 Initiation control protein YabA DUF641 PF04859.12 EFC50304.1 - 3.7 7.9 19.2 0.25 11.7 3.0 3.2 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Peptidase_S46 PF10459.9 EFC50304.1 - 4.8 5.7 13.4 1.2 7.7 4.9 1.9 1 1 1 2 2 2 0 Peptidase S46 COMP PF11598.8 EFC50304.1 - 5.5 7.5 10.3 2.2 8.8 0.8 3.7 3 1 2 5 5 5 0 Cartilage oligomeric matrix protein SlyX PF04102.12 EFC50304.1 - 6 7.6 10.3 12 6.6 0.9 2.8 1 1 1 2 2 2 0 SlyX HMMR_N PF15905.5 EFC50304.1 - 7.8 5.9 28.5 4.4 6.7 8.8 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DHHC PF01529.20 EFC50305.1 - 0.0023 18.0 3.5 0.0023 18.0 3.5 1.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase SpoIIM PF01944.17 EFC50305.1 - 0.066 13.2 2.5 0.084 12.9 2.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein M Ribosomal_L28 PF00830.19 EFC50306.1 - 1e-17 64.1 0.3 1.2e-17 63.9 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L28 family TPR_2 PF07719.17 EFC50307.1 - 0.085 13.0 0.5 33 4.9 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Ca_hom_mod PF14798.6 EFC50307.1 - 0.14 11.2 2.7 0.35 9.9 1.1 2.3 1 1 1 2 2 2 0 Calcium homeostasis modulator TPR_9 PF13371.6 EFC50307.1 - 0.16 12.1 0.0 0.39 10.9 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Acyl-CoA_ox_N PF14749.6 EFC50307.1 - 0.26 11.8 9.9 0.24 11.9 0.4 3.1 2 2 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Neugrin PF06413.11 EFC50308.1 - 8.7 6.3 16.9 0.53 10.3 6.5 2.2 2 0 0 2 2 2 0 Neugrin GNAT_acetyltr_2 PF13718.6 EFC50309.1 - 2.2e-92 308.6 0.0 3.5e-92 307.9 0.0 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 EFC50309.1 - 2.2e-61 206.8 0.0 4.7e-61 205.7 0.0 1.6 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 EFC50309.1 - 1.7e-56 191.6 6.7 1.7e-56 191.6 6.7 1.8 2 0 0 2 2 2 1 Possible tRNA binding domain DUF1726 PF08351.11 EFC50309.1 - 8.2e-32 109.0 0.8 1.6e-31 108.0 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 EFC50309.1 - 0.0012 19.1 0.1 0.51 10.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain BEN PF10523.9 EFC50309.1 - 0.012 15.9 0.1 0.031 14.5 0.1 1.7 1 0 0 1 1 1 0 BEN domain Acetyltransf_1 PF00583.25 EFC50309.1 - 0.013 15.8 0.0 0.038 14.2 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC50309.1 - 0.018 15.5 0.2 0.078 13.4 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Exo_endo_phos PF03372.23 EFC50310.1 - 5.9e-07 29.2 0.0 8.2e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RNA_pol_Rbc25 PF08292.12 EFC50311.1 - 6.8e-27 94.2 0.1 1.6e-20 73.7 0.0 2.5 1 1 1 2 2 2 2 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 EFC50311.1 - 1.3e-10 41.5 0.0 2.4e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 ERCC3_RAD25_C PF16203.5 EFC50312.1 - 6e-114 379.4 3.5 6e-114 379.4 3.5 2.1 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 EFC50312.1 - 4.1e-31 107.8 0.0 8.7e-31 106.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Helicase_C PF00271.31 EFC50312.1 - 1.6e-11 44.5 2.1 2.7e-11 43.8 0.3 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 EFC50312.1 - 2.1e-06 26.7 0.0 3.1e-06 26.2 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain CMS1 PF14617.6 EFC50312.1 - 1.3 8.3 9.9 3.5 6.9 9.9 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF4576 PF15144.6 EFC50312.1 - 4.4 7.2 5.0 40 4.2 1.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) Methyltransf_11 PF08241.12 EFC50313.1 - 6.7e-15 55.5 0.0 3e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC50313.1 - 7.3e-14 51.8 0.1 2.6e-13 50.0 0.1 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC50313.1 - 1.2e-13 51.5 0.0 5.1e-13 49.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC50313.1 - 5.8e-09 36.0 0.0 1.3e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 EFC50313.1 - 6.5e-09 35.5 0.0 1.7e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 EFC50313.1 - 1.5e-06 28.9 1.2 3.8e-06 27.6 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 EFC50313.1 - 0.00063 19.3 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 EFC50313.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_8 PF05148.15 EFC50313.1 - 0.014 15.2 0.0 0.23 11.3 0.0 2.2 1 1 0 1 1 1 0 Hypothetical methyltransferase Complex1_LYR_2 PF13233.6 EFC50313.1 - 0.039 14.7 0.7 0.085 13.6 0.7 1.6 1 0 0 1 1 1 0 Complex1_LYR-like Methyltransf_32 PF13679.6 EFC50313.1 - 0.074 13.0 3.0 0.11 12.4 0.0 2.4 3 0 0 3 3 3 0 Methyltransferase domain DUF4957 PF16318.5 EFC50313.1 - 0.12 12.4 2.1 0.24 11.3 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4957) PEN-2 PF10251.9 EFC50314.1 - 0.004 17.5 2.4 0.0078 16.6 2.4 1.6 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase SPC25 PF06703.11 EFC50314.1 - 0.041 13.7 3.5 0.029 14.2 2.0 1.5 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DHHC PF01529.20 EFC50314.1 - 1.2 9.2 4.5 1.3 9.2 1.5 1.9 1 1 1 2 2 2 0 DHHC palmitoyltransferase CCDC24 PF15669.5 EFC50315.1 - 1.3e-38 132.9 0.3 1.3e-38 132.9 0.3 1.8 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 24 family ARS2 PF04959.13 EFC50315.1 - 0.087 13.2 1.2 2 8.7 0.2 2.3 2 0 0 2 2 2 0 Arsenite-resistance protein 2 TniQ PF06527.11 EFC50315.1 - 0.12 13.1 0.1 0.38 11.5 0.0 1.9 2 1 0 2 2 2 0 TniQ Med26 PF08711.11 EFC50316.1 - 4.7e-13 48.9 0.9 1.9e-12 47.0 0.9 2.1 1 0 0 1 1 1 1 TFIIS helical bundle-like domain FAM91_N PF14647.6 EFC50317.1 - 2.4e-115 385.1 2.5 3.4e-115 384.6 2.5 1.1 1 0 0 1 1 1 1 FAM91 N-terminus FAM91_C PF14648.6 EFC50317.1 - 4.4e-85 286.1 0.0 6.8e-85 285.5 0.0 1.3 1 0 0 1 1 1 1 FAM91 C-terminus DUF3860 PF12976.7 EFC50317.1 - 0.071 13.1 0.0 0.46 10.5 0.0 2.3 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3860) GTP1_OBG PF01018.22 EFC50318.1 - 1.1e-48 164.8 5.7 1.6e-48 164.3 5.7 1.2 1 0 0 1 1 1 1 GTP1/OBG MMR_HSR1 PF01926.23 EFC50318.1 - 2.9e-20 72.5 0.0 2.1e-19 69.7 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC50318.1 - 1.6e-08 34.3 0.0 6.5e-07 29.0 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 EFC50318.1 - 0.00022 20.8 0.1 0.28 10.7 0.0 2.7 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC50318.1 - 0.0037 16.8 0.0 0.18 11.2 0.0 2.5 2 1 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 EFC50318.1 - 0.0043 16.5 0.1 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1_C PF08438.10 EFC50318.1 - 0.013 16.1 1.5 0.026 15.1 0.1 2.3 3 0 0 3 3 3 0 GTPase of unknown function C-terminal ABC_tran PF00005.27 EFC50318.1 - 3.4 8.2 5.6 1.1 9.8 0.1 2.5 2 1 0 2 2 2 0 ABC transporter RNase_PH PF01138.21 EFC50319.1 - 1.6e-19 70.7 0.0 2.5e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 EFC50319.1 - 7.4e-09 35.5 0.0 1.5e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 TFIIB PF00382.19 EFC50320.1 - 6.9e-16 58.0 0.5 3.9e-08 33.2 0.4 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 EFC50320.1 - 7.4e-09 35.9 1.0 7.4e-09 35.9 1.0 2.7 2 1 0 2 2 2 1 Brf1-like TBP-binding domain DUF4548 PF15081.6 EFC50320.1 - 0.1 12.5 2.7 0.16 11.7 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4548) TPR_1 PF00515.28 EFC50322.1 - 0.0002 21.0 0.4 0.58 10.1 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50322.1 - 0.00089 19.2 0.0 1.9 8.8 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50322.1 - 0.081 13.2 0.0 5.2 7.4 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TetR_C_2 PF08361.11 EFC50322.1 - 0.13 12.4 1.4 0.3 11.2 0.3 2.2 2 0 0 2 2 2 0 MAATS-type transcriptional repressor, C-terminal region TPR_8 PF13181.6 EFC50322.1 - 0.2 11.9 1.9 11 6.5 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_23 PF13476.6 EFC50322.1 - 2.1 8.8 11.7 2 8.9 0.4 3.2 3 0 0 3 3 3 0 AAA domain Corazonin PF17308.2 EFC50323.1 - 0.013 15.9 0.0 0.043 14.2 0.0 1.8 1 0 0 1 1 1 0 Pro-corazonin TPR_7 PF13176.6 EFC50323.1 - 0.038 14.0 0.0 0.59 10.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50323.1 - 0.061 13.5 0.2 0.26 11.5 0.2 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50323.1 - 0.083 13.1 0.2 0.38 11.0 0.2 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Nucleoporin_N PF08801.11 EFC50324.1 - 1.7e-83 280.8 1.5 1.6e-82 277.6 1.5 2.2 1 1 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 EFC50324.1 - 3.2e-17 62.5 17.8 1.4e-16 60.4 16.6 2.0 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal ABC_transp_aux PF09822.9 EFC50324.1 - 0.032 13.7 0.0 0.032 13.7 0.0 2.7 3 1 0 3 3 3 0 ABC-type uncharacterized transport system Vps39_1 PF10366.9 EFC50324.1 - 8.2 6.8 11.5 0.2 11.9 1.7 3.4 4 0 0 4 4 4 0 Vacuolar sorting protein 39 domain 1 TIP49 PF06068.13 EFC50325.1 - 3.2e-167 556.1 3.6 3.9e-167 555.8 3.6 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 EFC50325.1 - 5.3e-21 74.5 0.0 2.9e-20 72.2 0.0 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 EFC50325.1 - 6.6e-11 42.8 0.4 2.2e-06 28.2 0.0 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 EFC50325.1 - 3.5e-10 39.8 0.3 1.7e-06 27.9 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 EFC50325.1 - 4.9e-06 26.9 0.0 0.017 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 EFC50325.1 - 0.00011 22.2 0.1 0.024 14.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 EFC50325.1 - 0.00033 21.1 0.0 0.0037 17.7 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 EFC50325.1 - 0.00041 20.7 0.4 0.38 11.1 0.1 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 EFC50325.1 - 0.0016 17.8 0.3 0.096 12.1 0.1 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 EFC50325.1 - 0.0027 18.2 0.1 0.01 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 EFC50325.1 - 0.005 16.6 0.1 3.4 7.3 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ResIII PF04851.15 EFC50325.1 - 0.0066 16.5 0.1 0.39 10.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 EFC50325.1 - 0.018 14.5 0.2 0.14 11.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 EFC50325.1 - 0.027 14.7 0.0 0.079 13.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 EFC50325.1 - 0.03 13.9 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 EFC50325.1 - 0.038 13.7 0.1 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein TniB PF05621.11 EFC50325.1 - 0.041 13.3 0.5 6 6.2 0.0 3.1 2 1 1 3 3 3 0 Bacterial TniB protein DnaB_C PF03796.15 EFC50325.1 - 0.053 12.9 0.0 0.11 11.8 0.0 1.6 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Zeta_toxin PF06414.12 EFC50325.1 - 0.064 12.5 0.3 0.22 10.8 0.2 1.8 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 EFC50325.1 - 0.068 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_11 PF13086.6 EFC50325.1 - 0.095 12.5 0.2 0.16 11.8 0.2 1.5 1 1 0 1 1 1 0 AAA domain Acetyltransf_1 PF00583.25 EFC50326.1 - 4e-13 49.6 0.0 5.4e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 EFC50326.1 - 1.2e-07 32.0 0.1 1.8e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 EFC50326.1 - 3.8e-07 30.1 0.1 5.8e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 EFC50326.1 - 0.026 14.7 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Rubredoxin_C PF18267.1 EFC50326.1 - 0.026 14.4 0.3 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Rubredoxin NAD+ reductase C-terminal domain Acetyltransf_CG PF14542.6 EFC50326.1 - 0.072 13.2 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase zf-CCHC PF00098.23 EFC50326.1 - 6.1 7.1 5.7 0.97 9.6 1.1 2.1 2 0 0 2 2 2 0 Zinc knuckle WD40 PF00400.32 EFC50327.1 - 1.6e-11 44.6 13.5 0.0083 17.0 0.1 5.1 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50327.1 - 0.00093 19.5 2.4 0.18 12.2 0.4 3.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain TFIIF_beta PF02270.15 EFC50328.1 - 1.4e-17 63.6 0.2 2.4e-17 62.8 0.2 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 EFC50328.1 - 1.9e-06 28.6 2.7 5e-06 27.2 2.4 2.0 1 1 0 1 1 1 1 TFIIF, beta subunit N-terminus Tau95 PF09734.9 EFC50328.1 - 0.018 15.9 1.7 0.029 15.2 1.1 1.6 1 1 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Phage_rep_org_N PF09681.10 EFC50328.1 - 0.028 14.3 0.3 11 6.0 0.1 2.6 2 0 0 2 2 2 0 N-terminal phage replisome organiser (Phage_rep_org_N) Ycf54 PF10674.9 EFC50328.1 - 0.078 13.3 1.2 13 6.1 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2488) Mito_carr PF00153.27 EFC50329.1 - 3.3e-58 193.6 1.7 6.3e-19 67.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_22 PF03901.17 EFC50330.1 - 3.9e-39 135.1 32.0 4.7e-39 134.8 32.0 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF5453 PF17534.2 EFC50330.1 - 0.037 14.0 1.0 0.037 14.0 1.0 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5453) RRM_1 PF00076.22 EFC50331.1 - 0.0025 17.6 0.0 0.0073 16.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pex14_N PF04695.13 EFC50331.1 - 0.77 10.4 10.4 0.034 14.8 2.9 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Lactamase_B_2 PF12706.7 EFC50332.1 - 4.8e-14 52.4 0.0 8e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 EFC50332.1 - 3.8e-06 27.0 0.0 1.4e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Proteasome PF00227.26 EFC50334.1 - 6.9e-60 201.8 0.1 1.9e-59 200.4 0.1 1.6 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 EFC50334.1 - 9.2e-13 47.6 0.0 2.4e-12 46.3 0.0 1.8 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature M16C_assoc PF08367.11 EFC50335.1 - 9.1e-72 241.2 0.5 1.4e-71 240.5 0.5 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 EFC50335.1 - 1.4e-27 96.9 0.9 3.7e-22 79.2 0.1 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 EFC50335.1 - 2.1e-08 34.3 3.1 5e-08 33.1 0.1 3.1 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) Ras PF00071.22 EFC50336.1 - 3.8e-27 94.9 0.0 1.2e-26 93.2 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC50336.1 - 3e-12 46.8 0.0 1.2e-11 44.9 0.0 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 EFC50336.1 - 0.0011 19.0 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 EFC50336.1 - 0.0012 18.3 0.9 0.0024 17.3 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit CwfJ_C_2 PF04676.14 EFC50336.1 - 0.033 15.1 0.0 0.1 13.5 0.0 1.8 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 2 ATP_bind_1 PF03029.17 EFC50336.1 - 0.069 12.9 0.0 0.21 11.4 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Topo_Zn_Ribbon PF08272.11 EFC50336.1 - 0.12 12.1 0.0 0.81 9.4 0.0 2.4 2 0 0 2 2 2 0 Topoisomerase I zinc-ribbon-like IFT57 PF10498.9 EFC50338.1 - 4.2e-108 361.5 15.4 5.4e-108 361.2 15.4 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 ABC_tran_CTD PF16326.5 EFC50338.1 - 0.0013 18.9 8.8 0.03 14.6 5.4 3.2 1 1 2 3 3 3 2 ABC transporter C-terminal domain Tropomyosin_1 PF12718.7 EFC50338.1 - 0.0017 18.5 9.1 0.0017 18.5 9.1 2.4 2 2 1 3 3 1 1 Tropomyosin like NPV_P10 PF05531.12 EFC50338.1 - 0.01 16.3 13.1 0.21 12.0 0.5 3.6 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DASH_Dad4 PF08650.10 EFC50338.1 - 0.01 15.7 3.4 1.2 9.2 0.6 3.9 2 1 1 3 3 3 0 DASH complex subunit Dad4 DUF3450 PF11932.8 EFC50338.1 - 0.044 13.1 7.7 0.041 13.2 6.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) JAKMIP_CC3 PF16034.5 EFC50338.1 - 0.044 13.7 12.5 0.035 14.1 10.7 1.9 1 1 0 1 1 1 0 JAKMIP CC3 domain Laminin_II PF06009.12 EFC50338.1 - 0.057 13.4 12.8 0.43 10.6 2.6 2.7 1 1 1 2 2 2 0 Laminin Domain II Spectrin PF00435.21 EFC50338.1 - 0.12 12.9 7.2 0.06 13.8 3.7 2.4 1 1 1 2 2 2 0 Spectrin repeat Seryl_tRNA_N PF02403.22 EFC50338.1 - 0.21 11.9 9.3 0.61 10.3 8.7 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1043 PF06295.12 EFC50338.1 - 0.24 11.4 3.3 3.7 7.6 3.2 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Sec34 PF04136.15 EFC50338.1 - 0.35 10.7 4.9 0.23 11.4 1.4 2.2 1 1 1 2 2 2 0 Sec34-like family DHR10 PF18595.1 EFC50338.1 - 0.42 10.7 11.6 0.062 13.4 5.2 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Syntaxin-6_N PF09177.11 EFC50338.1 - 0.57 10.8 8.1 0.81 10.3 5.5 2.4 1 1 2 3 3 3 0 Syntaxin 6, N-terminal DUF1515 PF07439.11 EFC50338.1 - 0.63 10.1 4.3 1.4 9.0 0.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DUF1664 PF07889.12 EFC50338.1 - 0.98 9.5 13.4 0.86 9.6 4.6 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Snapin_Pallidin PF14712.6 EFC50338.1 - 1.1 9.8 9.5 0.73 10.3 2.9 2.8 2 0 0 2 2 2 0 Snapin/Pallidin KxDL PF10241.9 EFC50338.1 - 1.3 9.3 8.9 1.8 8.9 0.2 3.6 2 1 2 4 4 4 0 Uncharacterized conserved protein BLOC1_2 PF10046.9 EFC50338.1 - 1.9 8.8 12.5 13 6.2 5.6 3.1 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.13 EFC50338.1 - 2.3 7.4 11.8 0.66 9.2 2.2 2.2 1 1 1 2 2 2 0 TMPIT-like protein FapA PF03961.13 EFC50338.1 - 2.3 6.7 13.0 0.67 8.5 8.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A Fez1 PF06818.15 EFC50338.1 - 3.3 8.1 18.5 3.1 8.2 10.7 2.9 1 1 1 2 2 2 0 Fez1 PspB PF06667.12 EFC50338.1 - 3.6 7.7 7.1 1.2 9.3 0.8 3.0 3 0 0 3 3 2 0 Phage shock protein B FlaC_arch PF05377.11 EFC50338.1 - 5.2 7.6 11.6 35 4.9 3.4 3.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Myb_DNA-binding PF00249.31 EFC50340.1 - 2.9e-47 158.6 32.9 5.9e-14 52.0 0.3 6.2 5 1 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC50340.1 - 9.8e-41 137.8 29.6 2.4e-13 50.1 0.0 6.8 3 2 4 7 7 7 5 Myb-like DNA-binding domain Rap1_C PF11626.8 EFC50340.1 - 4.3e-06 26.7 8.9 0.17 12.0 0.1 4.4 2 1 2 4 4 4 3 TRF2-interacting telomeric protein/Rap1 - C terminal domain SLIDE PF09111.10 EFC50340.1 - 0.0037 17.3 0.2 0.0037 17.3 0.2 6.1 5 1 2 7 7 7 3 SLIDE Myb_DNA-bind_4 PF13837.6 EFC50340.1 - 0.071 13.5 31.1 0.25 11.7 3.2 7.0 3 2 3 6 6 6 0 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 EFC50340.1 - 3.8 7.8 13.3 1.7 8.9 0.4 4.8 3 1 3 6 6 6 0 SANT/Myb-like domain of DAMP1 Syntaxin PF00804.25 EFC50341.1 - 9.2e-05 22.2 16.4 0.0079 15.9 2.1 2.2 2 0 0 2 2 2 2 Syntaxin Syntaxin_2 PF14523.6 EFC50341.1 - 0.00013 22.3 7.1 0.00013 22.3 7.1 2.2 2 1 0 2 2 2 1 Syntaxin-like protein SNF5 PF04855.12 EFC50341.1 - 0.036 13.8 8.8 0.031 14.1 7.5 1.4 1 1 0 1 1 1 0 SNF5 / SMARCB1 / INI1 DUF3685 PF12452.8 EFC50341.1 - 0.039 13.7 0.2 0.039 13.7 0.2 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3685) DUF2203 PF09969.9 EFC50341.1 - 0.73 10.6 8.9 1.9 9.2 0.6 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FadA PF09403.10 EFC50341.1 - 1 9.9 12.5 0.47 11.0 6.4 2.6 2 0 0 2 2 2 0 Adhesion protein FadA CH PF00307.31 EFC50342.1 - 2.2e-16 60.0 0.8 3e-08 33.8 0.2 2.5 2 0 0 2 2 2 2 Calponin homology (CH) domain DEAD PF00270.29 EFC50343.1 - 7.7e-49 165.8 0.0 2.1e-48 164.4 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50343.1 - 1.5e-30 105.8 4.7 2.1e-29 102.1 0.0 3.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain TPR_2 PF07719.17 EFC50344.1 - 0.035 14.2 0.4 0.12 12.6 0.4 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50344.1 - 0.064 13.1 0.5 0.2 11.5 0.5 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50345.1 - 6e-46 150.9 1.8 4.1e-06 26.5 0.1 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50345.1 - 2.9e-44 147.1 6.6 3.6e-07 29.7 0.1 8.6 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50345.1 - 2.2e-35 117.9 3.7 1.4e-05 24.9 0.0 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50345.1 - 1.3e-33 114.4 3.3 4.3e-08 32.7 0.0 8.2 5 3 3 8 8 8 6 TPR repeat TPR_12 PF13424.6 EFC50345.1 - 1.3e-25 89.5 5.7 3.2e-07 30.6 0.1 8.5 5 3 2 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50345.1 - 9.2e-21 74.2 0.0 0.00017 22.2 0.0 6.2 5 2 2 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50345.1 - 1.1e-19 68.9 1.8 0.0016 18.3 0.0 8.1 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50345.1 - 5.2e-19 67.3 0.0 0.035 14.9 0.0 9.2 4 2 6 10 10 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 EFC50345.1 - 8.3e-18 64.3 0.0 0.00055 20.0 0.0 5.3 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50345.1 - 1.8e-17 62.4 9.0 0.0024 18.1 0.0 8.3 8 2 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50345.1 - 3.4e-16 59.5 0.2 7.2e-06 26.4 0.0 6.5 5 2 2 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50345.1 - 1.1e-14 54.4 2.0 0.0086 16.3 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 EFC50345.1 - 9.2e-13 47.9 0.9 4.2 8.2 0.0 8.6 10 0 0 10 10 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50345.1 - 7.1e-11 41.6 6.2 0.1 12.5 0.1 7.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_3 PF07720.12 EFC50345.1 - 7.3e-07 29.0 6.0 1.9 8.6 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat NARP1 PF12569.8 EFC50345.1 - 3.9e-06 26.0 0.8 5.4 5.8 0.0 4.2 3 1 0 4 4 4 1 NMDA receptor-regulated protein 1 TPR_15 PF13429.6 EFC50345.1 - 1.3e-05 24.5 0.0 0.23 10.6 0.0 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat ChAPs PF09295.10 EFC50345.1 - 0.00016 20.9 0.0 0.018 14.1 0.0 2.9 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) SNAP PF14938.6 EFC50345.1 - 0.00042 19.8 0.8 0.071 12.5 0.0 3.6 3 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 EFC50345.1 - 0.0031 16.9 0.0 0.78 9.0 0.0 2.9 2 1 1 3 3 3 1 MalT-like TPR region PknG_TPR PF16918.5 EFC50345.1 - 0.0039 16.0 0.0 0.78 8.4 0.0 2.3 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat MIT PF04212.18 EFC50345.1 - 0.01 15.9 6.3 22 5.2 0.1 6.3 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 EFC50345.1 - 0.015 15.5 1.7 12 6.4 0.1 4.1 3 0 0 3 3 3 0 PPR repeat Euplotes_phero PF05842.11 EFC50345.1 - 0.015 15.8 0.0 0.059 14.0 0.0 1.9 1 1 0 1 1 1 0 Euplotes octocarinatus mating pheromone protein Wzy_C_2 PF11846.8 EFC50345.1 - 0.019 14.9 0.0 2.8 7.8 0.0 2.6 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal TPR_20 PF14561.6 EFC50345.1 - 0.021 15.1 0.0 38 4.7 0.0 4.5 4 1 1 5 5 4 0 Tetratricopeptide repeat DUF3808 PF10300.9 EFC50345.1 - 0.025 13.3 3.0 0.39 9.4 0.2 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF3808) Coatomer_E PF04733.14 EFC50345.1 - 0.034 13.6 1.6 6.3 6.1 0.1 2.8 2 1 1 3 3 3 0 Coatomer epsilon subunit SRP_TPR_like PF17004.5 EFC50345.1 - 0.038 14.0 1.7 2.1 8.4 0.2 3.1 3 1 0 3 3 2 0 Putative TPR-like repeat Cas_Csa5 PF09702.10 EFC50345.1 - 0.074 13.3 0.1 1.5 9.1 0.2 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csa5) TPR_4 PF07721.14 EFC50345.1 - 0.12 13.1 0.0 35 5.4 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat Kelch_4 PF13418.6 EFC50346.1 - 1.4e-36 124.3 3.3 1.2e-09 38.0 0.0 5.6 5 1 1 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC50346.1 - 9.3e-25 86.2 0.1 7.9e-06 25.7 0.1 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 EFC50346.1 - 1.4e-24 85.5 0.2 1.5e-05 25.1 0.0 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 EFC50346.1 - 1.8e-19 69.6 0.1 4.9e-06 26.7 0.0 5.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 EFC50346.1 - 7.7e-18 63.7 1.6 0.00011 22.0 0.1 5.3 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 EFC50346.1 - 1.5e-12 46.8 0.0 0.0012 18.4 0.0 3.8 3 0 0 3 3 3 3 Kelch motif p25-alpha PF05517.12 EFC50346.1 - 2e-09 37.8 8.2 8.6e-09 35.7 0.9 3.3 3 1 1 4 4 4 2 p25-alpha B-block_TFIIIC PF04182.12 EFC50347.1 - 1e-13 51.2 8.0 1.1e-12 47.9 0.4 3.6 3 0 0 3 3 3 2 B-block binding subunit of TFIIIC Myb_DNA-binding PF00249.31 EFC50347.1 - 8.2e-07 29.1 0.1 2.9e-06 27.3 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Homeodomain PF00046.29 EFC50347.1 - 5e-06 26.3 1.5 2.2e-05 24.2 0.2 2.8 2 0 0 2 2 2 1 Homeodomain Myb_DNA-bind_6 PF13921.6 EFC50347.1 - 0.008 16.4 0.1 0.053 13.8 0.1 2.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 EFC50347.1 - 0.046 14.0 0.6 0.6 10.5 0.0 3.3 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Methyltransf_14 PF08484.11 EFC50347.1 - 0.048 13.5 0.1 0.13 12.1 0.1 1.7 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain Costars PF14705.6 EFC50347.1 - 0.065 13.4 0.2 0.21 11.8 0.2 1.9 1 0 0 1 1 1 0 Costars DNA_pol_alpha_N PF12254.8 EFC50347.1 - 1.9 8.6 5.9 1.5 9.0 1.5 3.0 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal CCCAP PF15964.5 EFC50348.1 - 1.6e-05 23.4 98.9 0.00074 18.0 78.7 3.3 3 0 0 3 3 3 3 Centrosomal colon cancer autoantigen protein family bZIP_1 PF00170.21 EFC50348.1 - 0.0022 18.0 5.1 0.0022 18.0 5.1 10.4 8 4 3 11 11 11 4 bZIP transcription factor DUF4686 PF15742.5 EFC50348.1 - 0.0023 17.2 6.5 0.0023 17.2 6.5 4.2 2 1 2 4 4 4 1 Domain of unknown function (DUF4686) CENP-F_leu_zip PF10473.9 EFC50348.1 - 0.01 15.9 24.1 0.01 15.9 24.1 8.8 3 1 6 9 9 9 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Mad3_BUB1_I_2 PF17014.5 EFC50348.1 - 0.042 14.0 4.1 0.17 12.0 1.1 3.2 2 0 0 2 2 2 0 Putative Mad3/BUB1 like region 1 protein SlyX PF04102.12 EFC50348.1 - 0.17 12.5 0.1 0.17 12.5 0.1 10.9 5 2 8 13 13 13 0 SlyX ADIP PF11559.8 EFC50348.1 - 0.3 11.2 113.5 0.73 9.9 9.2 8.5 4 2 4 8 8 8 0 Afadin- and alpha -actinin-Binding DUF3450 PF11932.8 EFC50348.1 - 1.7 7.9 93.4 0.16 11.2 18.1 8.3 4 2 4 8 8 8 0 Protein of unknown function (DUF3450) Kinesin PF00225.23 EFC50349.1 - 3.3e-18 65.7 0.0 3.3e-18 65.7 0.0 4.1 3 2 1 4 4 4 1 Kinesin motor domain PH PF00169.29 EFC50349.1 - 5.3e-17 62.2 0.1 3e-16 59.8 0.1 2.4 1 0 0 1 1 1 1 PH domain Microtub_bd PF16796.5 EFC50349.1 - 2.8e-06 27.3 4.7 9e-05 22.4 0.0 4.2 3 0 0 3 3 3 1 Microtubule binding PH_11 PF15413.6 EFC50349.1 - 0.00094 19.6 4.1 0.0013 19.1 0.0 3.5 3 0 0 3 3 3 1 Pleckstrin homology domain PH_6 PF15406.6 EFC50349.1 - 0.027 14.8 0.0 0.13 12.5 0.0 2.3 1 0 0 1 1 1 0 Pleckstrin homology domain Pox_A_type_inc PF04508.12 EFC50349.1 - 0.12 12.3 17.3 5.8 6.9 0.5 6.2 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat PurL_C PF16904.5 EFC50349.1 - 1.9 8.8 9.6 0.15 12.4 0.8 3.3 2 1 0 2 2 2 0 Phosphoribosylformylglycinamidine synthase II C-terminus BBS1 PF14779.6 EFC50350.1 - 0.033 13.6 0.1 2.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 PHF5 PF03660.14 EFC50351.1 - 4.4e-48 161.8 15.1 4.8e-48 161.7 15.1 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 EFC50351.1 - 0.06 11.2 8.2 0.064 11.1 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 C1_2 PF03107.16 EFC50351.1 - 0.39 11.1 17.8 0.6 10.5 3.5 2.6 1 1 1 2 2 2 0 C1 domain DZR PF12773.7 EFC50351.1 - 1.2 9.2 15.5 2.2 8.4 1.2 3.0 1 1 2 3 3 3 0 Double zinc ribbon RNA_pol_Rpb2_7 PF04560.20 EFC50351.1 - 2.6 8.5 4.9 2.6 8.5 0.6 2.2 1 1 1 2 2 2 0 RNA polymerase Rpb2, domain 7 ABC_transp_aux PF09822.9 EFC50352.1 - 2.3e-09 37.1 0.1 4e-09 36.3 0.1 1.3 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DUF2194 PF09960.9 EFC50352.1 - 6.8e-05 21.4 0.4 9.2e-05 21.0 0.1 1.4 2 0 0 2 2 2 1 Uncharacterised protein conserved in bacteria (DUF2194) DDOST_48kD PF03345.14 EFC50352.1 - 0.00061 18.7 0.0 0.023 13.6 0.0 2.1 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta ThuA PF06283.11 EFC50352.1 - 0.0013 19.0 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 Trehalose utilisation DUF4159 PF13709.6 EFC50352.1 - 0.18 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) TIM PF00121.18 EFC50353.1 - 4.2e-88 294.8 0.6 4.7e-88 294.7 0.6 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase zf-SNAP50_C PF12251.8 EFC50354.1 - 6.3e-64 215.3 12.8 6.3e-64 215.3 12.8 1.8 2 0 0 2 2 2 1 snRNA-activating protein of 50kDa MW C terminal Meis_PKNOX_N PF16493.5 EFC50355.1 - 0.62 10.4 5.6 0.18 12.1 0.8 2.4 2 1 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 THOC7 PF05615.13 EFC50355.1 - 2.2 8.6 19.5 0.1 12.9 7.3 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 APG6_N PF17675.1 EFC50355.1 - 5.2 7.6 18.2 1.5 9.3 7.7 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region IBN_N PF03810.19 EFC50356.1 - 2.4e-09 37.0 0.3 6.9e-09 35.5 0.3 1.9 1 0 0 1 1 1 1 Importin-beta N-terminal domain HrpB_C PF08482.10 EFC50357.1 - 0.066 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 ATP-dependent helicase C-terminal NUDIX PF00293.28 EFC50359.1 - 0.00021 21.3 0.0 0.0012 18.9 0.0 2.1 2 0 0 2 2 2 1 NUDIX domain Nudc_N PF14050.6 EFC50359.1 - 0.32 11.0 4.1 0.32 11.0 1.3 2.4 2 0 0 2 2 2 0 N-terminal conserved domain of Nudc. MM_CoA_mutase PF01642.22 EFC50360.1 - 1.2e-229 763.2 0.7 1.4e-229 762.9 0.7 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase B12-binding PF02310.19 EFC50360.1 - 3e-15 56.3 0.3 6.3e-15 55.3 0.3 1.6 1 0 0 1 1 1 1 B12 binding domain Sec1 PF00995.23 EFC50361.1 - 5.7e-113 379.1 9.5 6.5e-113 379.0 9.5 1.0 1 0 0 1 1 1 1 Sec1 family p25-alpha PF05517.12 EFC50361.1 - 0.32 11.2 5.2 2.3 8.4 2.6 2.6 2 0 0 2 2 2 0 p25-alpha DUF4665 PF15679.5 EFC50361.1 - 4.1 8.1 11.7 2.4 8.9 7.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) Rap_GAP PF02145.15 EFC50362.1 - 1.5e-50 171.3 1.7 1.1e-49 168.5 0.0 2.8 2 1 0 2 2 2 1 Rap/ran-GAP Ribosomal_L23 PF00276.20 EFC50364.1 - 1.2e-16 60.9 0.5 1.2e-16 60.9 0.5 2.1 2 0 0 2 2 2 1 Ribosomal protein L23 Snurportin1 PF11538.8 EFC50364.1 - 0.026 14.7 1.2 0.1 12.8 1.2 2.0 1 0 0 1 1 1 0 Snurportin1 Med9 PF07544.13 EFC50364.1 - 0.13 12.4 6.2 0.42 10.7 6.2 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 NACHT_N PF17100.5 EFC50364.1 - 0.89 9.4 9.7 1.6 8.5 9.7 1.4 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase SET PF00856.28 EFC50365.1 - 1.1e-25 90.9 0.4 3.7e-25 89.3 0.4 1.7 1 1 0 1 1 1 1 SET domain SPRY PF00622.28 EFC50366.1 - 4.2e-12 46.2 0.8 8.7e-12 45.2 0.8 1.5 1 0 0 1 1 1 1 SPRY domain Choline_kinase PF01633.20 EFC50367.1 - 8.5e-48 162.8 1.5 1.5e-47 162.0 1.5 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 EFC50367.1 - 4.9e-09 36.5 0.0 7.4e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 EFC50367.1 - 5.4e-05 22.6 0.9 7.5e-05 22.2 0.9 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 EFC50367.1 - 0.00081 18.7 0.1 0.00098 18.4 0.1 1.1 1 0 0 1 1 1 1 Fructosamine kinase DUF1679 PF07914.11 EFC50367.1 - 0.051 12.4 0.1 0.11 11.4 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Ribosomal_L28e PF01778.17 EFC50368.1 - 2.6e-28 99.1 0.4 2.6e-28 99.1 0.4 2.2 2 1 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 EFC50368.1 - 1.1e-10 42.0 19.0 1.1e-10 42.0 19.0 2.0 2 1 0 2 2 2 1 Mak16 protein C-terminal region Exonuc_VII_L PF02601.15 EFC50368.1 - 0.076 12.6 4.0 0.097 12.2 4.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TetR_C_37 PF18665.1 EFC50368.1 - 0.14 12.8 3.8 0.18 12.4 2.8 1.7 1 1 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF1664 PF07889.12 EFC50368.1 - 0.31 11.1 2.9 0.48 10.5 2.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DEAD PF00270.29 EFC50369.1 - 2.4e-46 157.7 0.8 1.3e-45 155.4 0.8 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50369.1 - 6.4e-29 100.5 0.4 1.5e-25 89.7 0.0 3.7 5 0 0 5 5 5 2 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFC50369.1 - 1.9e-14 53.6 0.2 3.8e-14 52.6 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 EFC50369.1 - 4e-10 40.0 0.1 6.2e-08 32.8 0.1 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFC50369.1 - 0.0057 15.9 0.0 0.024 13.9 0.0 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SNF2_N PF00176.23 EFC50369.1 - 0.01 14.6 0.0 0.022 13.5 0.0 1.4 1 1 0 1 1 1 0 SNF2 family N-terminal domain CMS1 PF14617.6 EFC50369.1 - 0.04 13.2 0.0 0.074 12.4 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF5062 PF16691.5 EFC50369.1 - 0.06 13.5 0.1 0.16 12.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5062) Cpn60_TCP1 PF00118.24 EFC50370.1 - 4.3e-166 553.4 6.0 4.9e-166 553.2 6.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sec16_C PF12931.7 EFC50372.1 - 1.1e-41 143.5 8.7 2.6e-26 93.0 6.0 2.4 1 1 1 2 2 2 2 Sec23-binding domain of Sec16 Sec16 PF12932.7 EFC50372.1 - 3.6e-07 30.8 0.0 2.2e-06 28.3 0.0 2.5 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Nup96 PF12110.8 EFC50372.1 - 0.012 14.8 0.5 0.024 13.7 0.5 1.5 1 0 0 1 1 1 0 Nuclear protein 96 S4 PF01479.25 EFC50373.1 - 1.6e-05 24.5 0.0 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 EFC50373.1 - 0.014 16.3 2.0 0.014 16.3 2.0 2.2 2 1 0 2 2 2 0 Ribosomal protein S4/S9 N-terminal domain DUF2451 PF10474.9 EFC50374.1 - 4.1e-62 210.0 3.6 4.1e-62 210.0 3.6 3.0 3 1 0 3 3 3 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 EFC50374.1 - 1.2e-38 133.1 19.3 4.1e-37 128.1 15.5 3.4 2 1 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF3464 PF11947.8 EFC50374.1 - 0.018 14.8 0.0 0.074 12.8 0.0 2.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 RNAse_A_bac PF18431.1 EFC50374.1 - 1.8 9.5 5.3 2.3 9.2 0.4 3.6 4 0 0 4 4 4 0 Bacterial CdiA-CT RNAse A domain Pyrophosphatase PF00719.19 EFC50375.1 - 4.4e-55 185.8 0.0 5.5e-55 185.5 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF3467 PF11950.8 EFC50377.1 - 0.023 14.9 4.9 0.041 14.1 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3467) Ribosomal_L11 PF00298.19 EFC50377.1 - 6.5 7.3 6.2 12 6.5 0.4 3.2 1 1 1 2 2 2 0 Ribosomal protein L11, RNA binding domain DEAD PF00270.29 EFC50378.1 - 3.9e-40 137.5 0.6 8e-40 136.5 0.3 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50378.1 - 9.3e-31 106.5 0.4 7.2e-30 103.6 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50378.1 - 4.3e-09 36.6 0.2 1e-08 35.3 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 EFC50378.1 - 7.2e-06 25.5 0.3 1.6e-05 24.4 0.1 1.7 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit SWI2_SNF2 PF18766.1 EFC50378.1 - 0.022 14.4 0.2 0.044 13.4 0.2 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase PG_binding_2 PF08823.11 EFC50378.1 - 0.027 14.8 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DUF445 PF04286.12 EFC50378.1 - 0.05 13.4 0.2 0.063 13.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF1858 PF08984.11 EFC50378.1 - 0.069 13.3 0.0 2 8.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1858) Kinesin PF00225.23 EFC50379.1 - 6.9e-83 278.3 1.0 6.9e-83 278.3 1.0 3.2 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 EFC50379.1 - 2.8e-25 89.0 0.1 2e-24 86.3 0.1 2.6 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 EFC50379.1 - 0.00036 21.0 1.0 0.0069 16.8 0.0 3.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 EFC50379.1 - 0.0012 19.2 0.7 0.15 12.3 0.0 3.2 2 0 0 2 2 2 1 AAA domain Dynamin_M PF01031.20 EFC50380.1 - 4e-101 338.0 0.0 4e-101 338.0 0.0 2.2 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 EFC50380.1 - 2.6e-56 190.3 0.4 2.6e-56 190.3 0.4 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 EFC50380.1 - 3.4e-26 91.2 5.2 3.4e-26 91.2 5.2 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 EFC50380.1 - 2.3e-05 24.5 0.1 8.9e-05 22.5 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase ORF11CD3 PF10549.9 EFC50380.1 - 0.2 11.8 0.6 0.57 10.3 0.6 1.8 1 0 0 1 1 1 0 ORF11CD3 domain DUF1539 PF07560.11 EFC50380.1 - 0.64 10.1 5.1 0.26 11.4 2.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) DUF2142 PF09913.9 EFC50381.1 - 0.0084 15.0 0.8 0.021 13.7 0.2 1.8 2 0 0 2 2 2 1 Predicted membrane protein (DUF2142) Renin_r PF07850.14 EFC50381.1 - 0.23 12.1 5.9 0.083 13.5 2.6 2.0 2 1 0 2 2 2 0 Renin receptor-like protein ATP-synt_8 PF00895.20 EFC50381.1 - 5.1 7.6 6.7 1.2 9.6 0.8 2.7 3 0 0 3 3 3 0 ATP synthase protein 8 tRNA-synt_1 PF00133.22 EFC50382.1 - 1e-46 159.4 0.0 7.7e-30 103.7 0.0 3.4 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 EFC50382.1 - 6.2e-22 77.9 3.5 4e-10 39.0 0.0 4.8 5 1 0 5 5 5 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 EFC50382.1 - 1.7e-13 50.8 4.5 3.9e-13 49.6 4.5 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 EFC50382.1 - 7.5e-08 32.1 0.0 1.9e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain ADK PF00406.22 EFC50384.1 - 2.7e-15 56.8 0.0 1.8e-11 44.4 0.0 3.6 2 1 1 3 3 3 2 Adenylate kinase AAA_17 PF13207.6 EFC50384.1 - 0.00019 21.9 0.2 0.00019 21.9 0.2 4.2 2 2 1 3 3 3 1 AAA domain AAA_33 PF13671.6 EFC50384.1 - 0.00028 21.1 0.0 0.0019 18.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 EFC50384.1 - 0.0003 21.3 0.2 0.0003 21.3 0.2 5.2 4 2 0 4 4 4 1 AAA domain AAA PF00004.29 EFC50384.1 - 0.027 14.9 0.1 0.21 12.0 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 EFC50384.1 - 1 9.6 5.3 1.2 9.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain CK2S PF15011.6 EFC50386.1 - 0.018 14.9 0.2 0.056 13.3 0.2 1.7 1 0 0 1 1 1 0 Casein Kinase 2 substrate ASCH PF04266.14 EFC50386.1 - 0.23 12.1 2.3 0.91 10.1 0.3 2.5 2 0 0 2 2 2 0 ASCH domain RP-C_C PF11800.8 EFC50386.1 - 4.3 7.4 6.6 0.69 10.0 2.1 1.8 2 0 0 2 2 2 0 Replication protein C C-terminal region FA_hydroxylase PF04116.13 EFC50387.1 - 1.4e-28 99.9 9.9 1.4e-28 99.9 9.9 2.5 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily Sec63 PF02889.16 EFC50388.1 - 9.5e-156 516.5 8.9 5.5e-90 301.0 0.4 3.0 3 0 0 3 3 3 2 Sec63 Brl domain DEAD PF00270.29 EFC50388.1 - 1.1e-46 158.8 0.4 4.1e-25 88.6 0.2 3.0 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 EFC50388.1 - 3.3e-35 120.6 8.6 3.3e-35 120.6 8.6 2.8 3 0 0 3 3 3 1 N-terminal helicase PWI domain ResIII PF04851.15 EFC50388.1 - 6.9e-22 78.2 4.3 7e-13 48.9 0.0 3.9 4 0 0 4 4 4 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 EFC50388.1 - 1.5e-14 54.3 3.2 7.6e-08 32.7 0.0 5.3 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 EFC50388.1 - 1.8e-05 25.0 0.3 0.36 11.1 0.3 3.3 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 EFC50388.1 - 0.00035 20.4 0.0 1.3 8.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain DUF2075 PF09848.9 EFC50388.1 - 0.00093 18.5 0.0 0.06 12.6 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 EFC50388.1 - 0.048 13.1 0.0 2.4 7.6 0.0 2.7 2 0 0 2 2 2 0 PhoH-like protein SHMT PF00464.19 EFC50388.1 - 0.068 11.8 0.0 0.15 10.7 0.0 1.5 1 0 0 1 1 1 0 Serine hydroxymethyltransferase Flavi_DEAD PF07652.14 EFC50388.1 - 0.13 12.2 0.0 0.52 10.3 0.0 2.1 1 0 0 1 1 1 0 Flavivirus DEAD domain DUF148 PF02520.17 EFC50388.1 - 0.5 10.5 3.9 0.86 9.7 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF148 Syntaxin PF00804.25 EFC50389.1 - 2.4e-28 99.2 19.5 4.2e-28 98.4 19.5 1.4 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 EFC50389.1 - 3.9e-10 39.6 4.5 3.9e-10 39.6 4.5 2.2 2 0 0 2 2 2 1 SNARE domain Syntaxin_2 PF14523.6 EFC50389.1 - 0.0042 17.4 5.6 0.0042 17.4 5.6 3.1 2 1 0 2 2 2 1 Syntaxin-like protein DUF3671 PF12420.8 EFC50389.1 - 0.067 13.3 0.2 0.067 13.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function MCPsignal PF00015.21 EFC50389.1 - 0.13 12.0 7.7 0.2 11.5 0.1 2.9 2 2 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ABC1 PF03109.16 EFC50389.1 - 0.34 11.1 4.8 0.12 12.5 0.7 2.2 2 1 1 3 3 3 0 ABC1 family ORF6C PF10552.9 EFC50389.1 - 0.6 10.2 7.3 0.49 10.5 1.7 2.9 2 2 0 2 2 2 0 ORF6C domain Syntaxin-6_N PF09177.11 EFC50389.1 - 0.76 10.4 14.8 0.57 10.8 3.1 3.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF1664 PF07889.12 EFC50389.1 - 0.89 9.6 10.2 2.3 8.3 0.5 3.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 EFC50389.1 - 1.7 8.7 21.9 0.42 10.7 7.6 2.3 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TTL PF03133.15 EFC50390.1 - 2.6e-76 256.6 0.2 6.1e-76 255.4 0.0 1.7 2 1 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 EFC50390.1 - 7.8e-07 28.6 0.0 0.0026 17.1 0.0 3.2 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 EFC50390.1 - 2.4e-05 23.7 0.0 0.11 11.7 0.0 2.5 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_3 PF02655.14 EFC50390.1 - 0.023 14.7 0.0 0.94 9.5 0.0 2.5 2 0 0 2 2 2 0 ATP-grasp domain WD40 PF00400.32 EFC50391.1 - 6.9e-13 48.9 9.8 0.0023 18.7 0.4 8.9 10 0 0 10 10 10 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50391.1 - 2.3e-07 31.0 2.1 0.24 11.7 0.1 6.1 6 0 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DivIVA PF05103.13 EFC50392.1 - 0.002 18.2 16.5 0.23 11.6 4.7 3.2 2 1 1 3 3 3 2 DivIVA protein Leu_zip PF15294.6 EFC50392.1 - 0.021 14.4 15.7 0.086 12.3 8.7 2.7 2 1 0 2 2 2 0 Leucine zipper APG6_N PF17675.1 EFC50392.1 - 0.054 14.0 16.0 0.49 10.9 8.7 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region SlyX PF04102.12 EFC50392.1 - 0.065 13.9 10.3 0.15 12.7 0.1 3.7 2 1 1 3 3 3 0 SlyX Latarcin PF10279.9 EFC50392.1 - 0.12 12.8 6.9 0.091 13.2 1.8 2.6 1 1 1 2 2 2 0 Latarcin precursor Goodbye PF17109.5 EFC50392.1 - 0.2 12.1 0.3 0.2 12.1 0.3 2.8 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF4298 PF14131.6 EFC50392.1 - 0.23 11.4 0.2 0.23 11.4 0.2 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4298) Fez1 PF06818.15 EFC50392.1 - 0.38 11.2 15.6 0.67 10.4 14.7 1.8 1 1 1 2 2 2 0 Fez1 DUF3450 PF11932.8 EFC50392.1 - 0.59 9.4 16.3 0.86 8.9 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 EFC50392.1 - 0.7 9.9 8.6 1.1 9.2 2.1 3.0 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Peptidase_M3_N PF08439.10 EFC50392.1 - 0.95 9.8 6.5 2.4 8.5 0.2 3.2 3 0 0 3 3 3 0 Oligopeptidase F Pox_A_type_inc PF04508.12 EFC50392.1 - 1 9.4 4.9 4.1 7.4 0.0 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat JIP_LZII PF16471.5 EFC50392.1 - 2 8.6 11.2 0.16 12.1 3.3 2.9 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II YafQ_toxin PF15738.5 EFC50392.1 - 2.1 8.7 5.7 1.8 8.9 0.1 3.0 2 1 1 3 3 3 0 Bacterial toxin of type II toxin-antitoxin system, YafQ Fib_alpha PF08702.10 EFC50392.1 - 2.6 8.3 16.6 11 6.2 0.4 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Csm1_N PF18504.1 EFC50392.1 - 3 8.3 17.6 11 6.5 4.3 3.6 2 1 1 3 3 3 0 Csm1 N-terminal domain TMF_DNA_bd PF12329.8 EFC50392.1 - 3.8 7.6 19.8 7.7 6.6 0.9 3.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4404 PF14357.6 EFC50392.1 - 5.8 7.6 12.8 3.2 8.4 0.4 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4404) TMF_TATA_bd PF12325.8 EFC50392.1 - 6.9 6.9 17.0 13 6.0 4.8 3.4 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding TPR_1 PF00515.28 EFC50394.1 - 4.8e-25 86.3 21.3 0.00023 20.9 0.0 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50394.1 - 6.3e-25 85.2 14.8 0.011 15.8 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50394.1 - 9.1e-13 47.3 11.1 0.0019 18.3 0.0 8.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50394.1 - 1.9e-12 46.7 7.8 9.5e-05 22.0 0.0 5.8 6 0 0 6 6 6 3 TPR repeat TPR_12 PF13424.6 EFC50394.1 - 3.3e-08 33.7 9.4 1.9 8.9 0.0 7.7 5 3 4 9 9 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50394.1 - 1.8e-07 31.7 0.0 1.4 9.6 0.3 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50394.1 - 2e-05 25.0 1.7 0.96 10.0 0.0 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50394.1 - 9.8e-05 22.5 13.6 3.5 7.9 0.5 6.0 5 1 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 EFC50394.1 - 0.00016 21.5 7.2 0.48 10.6 0.0 6.6 7 0 0 7 7 6 1 Tetratricopeptide repeat CS PF04969.16 EFC50394.1 - 0.00031 21.7 1.5 0.001 20.0 0.4 2.5 2 0 0 2 2 2 1 CS domain TPR_9 PF13371.6 EFC50394.1 - 0.0005 20.1 0.0 8.4 6.6 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50394.1 - 0.00093 19.8 1.6 7.8 7.6 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50394.1 - 0.0012 19.4 3.2 31 5.5 0.0 6.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50394.1 - 0.0028 17.9 7.0 0.73 10.4 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC50394.1 - 0.21 11.7 4.5 2.2 8.4 0.3 3.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Caps_synth_GfcC PF06251.11 EFC50394.1 - 1.7 8.2 11.3 6.5 6.3 0.2 3.4 3 1 0 3 3 3 0 Capsule biosynthesis GfcC DEAD PF00270.29 EFC50395.1 - 1.5e-32 112.8 0.2 3.6e-32 111.5 0.1 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50395.1 - 5.9e-27 94.2 0.5 2e-26 92.5 0.2 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50395.1 - 2e-06 27.9 4.4 3.3e-06 27.2 0.6 2.7 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 EFC50395.1 - 0.073 13.4 1.1 3.9 7.7 0.2 3.2 2 1 1 3 3 3 0 AAA domain GRAM PF02893.20 EFC50396.1 - 7.5e-08 32.3 4.0 0.00015 21.6 0.1 3.4 3 0 0 3 3 3 2 GRAM domain HA2 PF04408.23 EFC50397.1 - 9.1e-26 90.3 0.0 1.9e-25 89.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 EFC50397.1 - 8.2e-21 74.2 0.1 2.4e-20 72.6 0.0 1.7 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Ank_2 PF12796.7 EFC50398.1 - 2.6e-05 24.7 1.7 0.0065 17.0 0.1 3.6 2 2 2 4 4 4 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC50398.1 - 0.0021 18.6 0.4 0.3 11.7 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC50398.1 - 0.0022 18.3 1.0 0.39 11.4 0.0 4.7 5 0 0 5 5 5 1 Ankyrin repeat Polysacc_synt_3 PF13440.6 EFC50398.1 - 0.014 14.6 0.0 0.029 13.6 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ank_5 PF13857.6 EFC50398.1 - 0.08 13.3 0.1 0.4 11.0 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.30 EFC50398.1 - 0.16 12.5 2.0 0.93 10.1 0.0 3.3 5 0 0 5 5 5 0 Ankyrin repeat HEAT PF02985.22 EFC50399.1 - 4.4e-10 38.9 3.0 0.96 9.9 0.0 8.8 9 0 0 9 9 9 2 HEAT repeat Cnd1 PF12717.7 EFC50399.1 - 3.2e-09 37.0 15.3 1.3e-06 28.5 0.2 6.6 6 3 1 8 8 8 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 EFC50399.1 - 0.00057 20.4 5.7 1.5 9.5 0.1 5.7 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 EFC50399.1 - 0.00077 19.1 9.3 0.44 10.1 0.1 5.2 3 2 1 5 5 5 1 CLASP N terminal DUF4042 PF13251.6 EFC50399.1 - 0.0025 17.6 3.3 0.14 11.8 0.4 4.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4042) HEAT_EZ PF13513.6 EFC50399.1 - 0.0059 17.1 4.3 2.4 8.8 0.0 5.8 6 0 0 6 6 6 1 HEAT-like repeat Nipped-B_C PF12830.7 EFC50399.1 - 0.011 15.7 1.7 12 5.8 0.0 4.3 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus VHS PF00790.19 EFC50399.1 - 0.025 14.5 0.4 22 4.9 0.0 4.5 5 1 1 6 6 6 0 VHS domain DUF4795 PF16043.5 EFC50399.1 - 0.78 9.3 4.7 0.28 10.7 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) IQ PF00612.27 EFC50400.1 - 0.028 14.2 0.3 0.028 14.2 0.3 3.1 3 0 0 3 3 3 0 IQ calmodulin-binding motif Pkinase PF00069.25 EFC50402.1 - 1.7e-14 53.9 4.3 4.4e-14 52.5 4.2 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50402.1 - 1.7e-13 50.4 1.4 3.2e-12 46.3 1.4 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 EFC50403.1 - 4.2e-06 27.0 0.0 1.3e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 C2 domain GRAM PF02893.20 EFC50403.1 - 0.035 14.0 0.2 0.11 12.3 0.2 1.8 1 0 0 1 1 1 0 GRAM domain NIF PF03031.18 EFC50404.1 - 8.2e-47 158.9 1.4 1.1e-46 158.4 1.4 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF4834 PF16118.5 EFC50404.1 - 1.1 10.3 3.6 0.32 12.0 0.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Arf PF00025.21 EFC50405.1 - 7.4e-53 178.6 0.6 5.6e-52 175.7 0.6 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC50405.1 - 8.8e-14 51.8 0.0 1.2e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC50405.1 - 8.1e-13 48.3 2.5 2.9e-10 39.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC50405.1 - 9.4e-10 38.2 0.0 1.3e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC50405.1 - 5.2e-09 35.9 0.1 9.7e-09 35.0 0.1 1.5 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFC50405.1 - 2.3e-05 24.5 0.0 3.4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 EFC50405.1 - 3e-05 23.5 0.2 0.00025 20.5 0.2 2.0 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC50405.1 - 0.00067 19.2 0.0 0.00084 18.9 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 EFC50406.1 - 1.6e-54 184.0 0.1 2.1e-54 183.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 EFC50406.1 - 1.7e-13 50.8 0.0 2.4e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 EFC50406.1 - 1.5e-12 47.3 2.3 2.5e-10 40.0 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC50406.1 - 1.5e-10 40.8 0.0 1.9e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 EFC50406.1 - 1.3e-09 37.9 0.0 1.6e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 EFC50406.1 - 3e-06 26.8 0.0 4.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 EFC50406.1 - 3.5e-06 27.1 0.0 4.6e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Rrn6 PF10214.9 EFC50407.1 - 0.039 12.5 7.7 0.04 12.4 7.7 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor GAGA_bind PF06217.12 EFC50407.1 - 0.15 12.3 10.8 0.18 12.0 10.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family BSMAP PF12280.8 EFC50407.1 - 0.84 9.8 5.8 1.1 9.4 5.8 1.2 1 0 0 1 1 1 0 Brain specific membrane anchored protein Cytomega_UL84 PF06284.11 EFC50407.1 - 8.7 4.7 13.0 11 4.3 13.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein GCP_C_terminal PF04130.13 EFC50408.1 - 3.9e-40 138.2 8.6 3.9e-40 138.2 8.6 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFC50408.1 - 2.8e-28 99.4 4.9 6.7e-28 98.2 4.9 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF3435 PF11917.8 EFC50408.1 - 0.1 11.5 6.9 0.17 10.7 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) GNT-I PF03071.15 EFC50409.1 - 6e-117 391.0 0.6 7.3e-117 390.8 0.6 1.0 1 0 0 1 1 1 1 GNT-I family Glycos_transf_2 PF00535.26 EFC50409.1 - 2.4e-05 24.2 0.5 5.6e-05 23.0 0.2 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 EFC50409.1 - 0.00015 21.8 0.0 0.00027 20.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 MGAT2 PF05060.14 EFC50409.1 - 0.00063 18.9 0.7 0.39 9.7 0.2 2.1 1 1 1 2 2 2 2 N-acetylglucosaminyltransferase II (MGAT2) Phage_TAC_3 PF06896.11 EFC50409.1 - 0.036 14.7 0.2 2 9.0 0.1 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone proteins, TAC NYD-SP28 PF14772.6 EFC50410.1 - 1.6e-21 76.2 17.4 1.6e-21 76.2 17.4 5.2 3 1 0 4 4 4 1 Sperm tail NYD-SP28_assoc PF14775.6 EFC50410.1 - 4.7e-08 33.0 5.8 4.7e-08 33.0 5.8 5.8 7 1 0 7 7 7 2 Sperm tail C-terminal domain Fumerase PF05681.14 EFC50412.1 - 4.9e-89 298.3 0.0 6.3e-89 298.0 0.0 1.1 1 0 0 1 1 1 1 Fumarate hydratase (Fumerase) Fumerase_C PF05683.12 EFC50412.1 - 1.1e-88 295.9 0.0 2.6e-88 294.7 0.0 1.6 2 0 0 2 2 2 1 Fumarase C-terminus IBN_N PF03810.19 EFC50412.1 - 0.033 14.1 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 Importin-beta N-terminal domain TPR_2 PF07719.17 EFC50413.1 - 2.8e-36 120.7 12.1 2.6e-06 27.1 0.1 10.0 9 1 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50413.1 - 6.7e-34 114.3 22.2 3.5e-08 32.9 0.1 9.5 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50413.1 - 4.9e-28 95.0 13.1 9.1e-07 28.6 0.1 8.4 8 1 0 8 8 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50413.1 - 1.8e-18 65.9 11.0 4e-08 32.8 1.1 7.6 7 1 1 8 8 8 4 TPR repeat TPR_12 PF13424.6 EFC50413.1 - 1.4e-17 63.8 5.6 0.0011 19.3 0.1 7.1 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50413.1 - 2.2e-14 52.9 0.0 0.65 11.0 0.0 8.4 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50413.1 - 3.2e-13 50.1 0.0 0.00018 22.0 0.0 5.9 5 2 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50413.1 - 3.6e-13 49.8 0.0 0.01 16.3 0.0 6.3 5 1 1 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50413.1 - 8.7e-12 45.1 25.6 5.1e-06 26.6 0.2 6.8 5 2 2 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 EFC50413.1 - 2.3e-11 43.2 16.2 0.052 14.0 0.1 9.1 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50413.1 - 3.1e-09 36.2 2.4 0.53 10.4 0.0 7.4 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50413.1 - 3.3e-08 33.7 12.6 0.39 11.4 0.1 8.6 11 0 0 11 11 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50413.1 - 9.3e-06 25.3 2.9 0.28 11.1 0.0 5.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 EFC50413.1 - 6.2e-05 22.4 0.4 1.2 8.3 0.0 4.9 2 2 1 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC50413.1 - 0.00018 21.5 16.8 0.21 11.7 0.8 6.3 6 1 1 7 7 7 2 Fis1 C-terminal tetratricopeptide repeat TPR_MalT PF17874.1 EFC50413.1 - 0.0011 18.4 0.5 0.17 11.2 0.2 2.9 1 1 2 3 3 3 2 MalT-like TPR region TPR_9 PF13371.6 EFC50413.1 - 0.015 15.4 0.0 3.8 7.7 0.0 3.6 4 1 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 EFC50413.1 - 0.022 15.4 5.7 60 4.5 0.0 5.8 5 1 0 5 5 5 0 Sel1 repeat TPR_3 PF07720.12 EFC50413.1 - 0.34 10.9 18.9 0.79 9.8 0.1 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC50413.1 - 0.41 10.1 1.9 15 5.1 0.0 3.6 4 0 0 4 4 3 0 SHNi-TPR ANAPC8 PF04049.13 EFC50413.1 - 1.5 8.9 7.4 3 7.9 0.1 3.1 3 0 0 3 3 3 0 Anaphase promoting complex subunit 8 / Cdc23 Ints3 PF10189.9 EFC50414.1 - 3.7e-48 163.8 1.1 1.1e-47 162.2 1.1 1.8 1 0 0 1 1 1 1 Integrator complex subunit 3 PAS_10 PF13596.6 EFC50414.1 - 0.0046 17.5 0.5 5.6 7.6 0.0 3.3 2 0 0 2 2 2 2 PAS domain HOCHOB PF17943.1 EFC50414.1 - 0.18 12.5 3.8 0.23 12.2 0.6 2.9 2 0 0 2 2 2 0 Homeobox-cysteine loop-homeobox Nop14 PF04147.12 EFC50414.1 - 1.9 6.6 44.9 0.32 9.1 0.1 3.3 3 0 0 3 3 3 0 Nop14-like family SDA1 PF05285.12 EFC50414.1 - 8.1 5.8 34.4 45 3.3 34.7 2.0 2 0 0 2 2 2 0 SDA1 Nbl1_Borealin_N PF10444.9 EFC50415.1 - 4.6e-15 55.0 1.5 3.8e-14 52.0 0.2 2.3 2 0 0 2 2 2 1 Nbl1 / Borealin N terminal PIF6 PF05341.11 EFC50416.1 - 0.12 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Per os infectivity factor 6 DUF3270 PF11674.8 EFC50416.1 - 0.47 10.7 3.1 0.73 10.0 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3270) ParA PF10609.9 EFC50417.1 - 1.3e-97 326.1 0.1 1.5e-97 325.9 0.1 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 EFC50417.1 - 1.1e-08 35.1 0.0 6.4e-08 32.7 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 EFC50417.1 - 3.2e-07 29.9 1.2 3.5e-05 23.1 0.1 2.7 2 1 0 2 2 2 2 Anion-transporting ATPase AAA_31 PF13614.6 EFC50417.1 - 1.5e-05 25.0 1.4 0.00051 20.0 1.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 EFC50417.1 - 9.2e-05 22.1 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 EFC50417.1 - 0.00028 20.4 0.2 0.34 10.3 0.0 2.6 2 1 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RsgA_GTPase PF03193.16 EFC50417.1 - 0.0011 18.8 2.0 0.003 17.5 0.4 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_26 PF13500.6 EFC50417.1 - 0.0028 17.5 0.1 0.076 12.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 EFC50417.1 - 0.0078 15.4 0.1 0.014 14.6 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain DAP3 PF10236.9 EFC50417.1 - 0.032 13.4 0.2 0.046 12.9 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MipZ PF09140.11 EFC50417.1 - 0.076 12.3 0.0 0.25 10.6 0.0 1.8 1 1 0 1 1 1 0 ATPase MipZ AAA_16 PF13191.6 EFC50417.1 - 0.093 13.1 0.1 0.18 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain RNA_pol_Rpc34 PF05158.12 EFC50418.1 - 1.1e-44 153.2 11.2 4.7e-28 98.6 5.9 2.3 1 1 1 2 2 2 2 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.12 EFC50418.1 - 4.6e-05 23.5 1.6 4.6e-05 23.5 1.6 1.7 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC DUF1788 PF08747.11 EFC50418.1 - 0.12 12.4 2.6 0.12 12.4 0.6 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1788) Peptidase_S76 PF13611.6 EFC50418.1 - 0.13 12.6 2.7 0.27 11.5 2.6 1.6 1 1 0 1 1 1 0 Serine peptidase of plant viral polyprotein, P1 DUF1492 PF07374.11 EFC50418.1 - 0.28 11.4 5.2 1.7 8.8 1.2 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1492) OB_NTP_bind PF07717.16 EFC50419.1 - 2.2e-18 66.4 0.1 9.8e-18 64.3 0.0 2.2 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 EFC50419.1 - 1.5e-16 60.6 0.1 1.5e-16 60.6 0.1 5.5 5 1 0 5 5 5 1 Helicase associated domain (HA2) Mrpl_C PF18502.1 EFC50420.1 - 0.056 13.7 2.2 0.13 12.5 2.2 1.6 1 0 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain BLOC1_2 PF10046.9 EFC50421.1 - 3.6e-25 88.1 5.5 3.6e-25 88.1 5.5 2.0 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 EFC50421.1 - 0.00031 20.8 1.2 0.00031 20.8 1.2 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) DUF5382 PF17354.2 EFC50421.1 - 0.0042 16.0 2.3 0.0053 15.7 2.3 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5382) NPV_P10 PF05531.12 EFC50421.1 - 0.0058 17.1 2.0 0.0058 17.1 2.0 2.0 2 0 0 2 2 2 1 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 EFC50421.1 - 0.0078 16.6 7.4 0.012 16.0 0.2 3.2 1 1 2 3 3 3 1 Flagella accessory protein C (FlaC) SCHIP-1 PF10148.9 EFC50421.1 - 0.027 14.1 7.2 0.029 14.0 7.2 1.0 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 PYRIN PF02758.16 EFC50421.1 - 0.038 14.1 0.4 0.1 12.8 0.4 1.9 1 1 0 1 1 1 0 PAAD/DAPIN/Pyrin domain APG6_N PF17675.1 EFC50421.1 - 0.24 11.9 10.6 0.32 11.5 10.1 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region DASH_Dam1 PF08653.10 EFC50421.1 - 0.38 10.6 5.1 1 9.2 0.4 3.1 1 1 2 3 3 3 0 DASH complex subunit Dam1 Maf1 PF09174.10 EFC50421.1 - 0.55 10.4 6.9 0.7 10.0 6.9 1.1 1 0 0 1 1 1 0 Maf1 regulator DUF948 PF06103.11 EFC50421.1 - 1 9.7 3.7 4.2 7.7 3.2 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) IL15 PF02372.15 EFC50421.1 - 1.2 9.2 5.8 0.46 10.5 1.6 2.0 1 1 1 2 2 2 0 Interleukin 15 Occludin_ELL PF07303.13 EFC50421.1 - 2.4 9.0 9.4 0.41 11.4 0.6 2.4 1 1 0 2 2 2 0 Occludin homology domain Exonuc_VII_L PF02601.15 EFC50421.1 - 4.1 6.9 9.7 5.1 6.6 9.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF745 PF05335.13 EFC50421.1 - 6.6 6.4 9.1 4.3 7.0 5.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) SNAP PF14938.6 EFC50422.1 - 2.6e-22 79.6 9.1 4.1e-22 78.9 9.1 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFC50422.1 - 1.2e-05 25.5 2.1 0.016 15.5 0.3 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50422.1 - 2.3e-05 24.1 2.4 0.52 10.5 0.0 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50422.1 - 0.015 15.9 2.1 30 5.5 0.1 4.9 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50422.1 - 0.017 15.8 0.2 1.6 9.5 0.1 3.5 3 1 2 5 5 5 0 Tetratricopeptide repeat YfiO PF13525.6 EFC50422.1 - 0.04 13.6 3.2 0.055 13.2 0.0 2.5 3 0 0 3 3 3 0 Outer membrane lipoprotein EF-1_beta_acid PF10587.9 EFC50422.1 - 0.054 14.0 0.7 0.054 14.0 0.7 4.6 6 0 0 6 6 3 0 Eukaryotic elongation factor 1 beta central acidic region TPR_8 PF13181.6 EFC50422.1 - 0.1 12.8 0.4 0.1 12.8 0.4 4.4 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50422.1 - 0.11 13.4 0.2 32 5.7 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50422.1 - 0.12 12.0 2.5 4.4 7.1 0.0 3.6 3 0 0 3 3 3 0 TPR repeat Clathrin PF00637.20 EFC50422.1 - 0.14 12.0 10.7 5.6 6.8 0.7 4.1 1 1 2 4 4 4 0 Region in Clathrin and VPS TPR_2 PF07719.17 EFC50422.1 - 1.6 9.1 12.3 1.9 8.8 0.3 4.7 5 1 2 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50422.1 - 3.9 7.5 12.1 0.25 11.2 0.2 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Sas10_Utp3 PF04000.15 EFC50423.1 - 0.00049 20.7 0.0 0.00055 20.5 0.0 1.1 1 0 0 1 1 1 1 Sas10/Utp3/C1D family DUF3818 PF12825.7 EFC50423.1 - 0.058 12.4 0.0 0.12 11.3 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) DEAD PF00270.29 EFC50424.1 - 1.7e-35 122.4 0.0 6.2e-35 120.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50424.1 - 4.8e-29 101.0 0.0 5.8e-28 97.5 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50424.1 - 4.3e-09 36.6 0.0 2.3e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 EFC50424.1 - 0.011 14.9 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UvrD-helicase PF00580.21 EFC50424.1 - 0.017 14.7 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 EFC50424.1 - 0.03 14.6 0.2 1.5 9.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Helicase_C_2 PF13307.6 EFC50424.1 - 0.037 14.2 0.0 0.061 13.5 0.0 1.3 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_19 PF13245.6 EFC50424.1 - 0.048 14.0 0.0 0.073 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 EFC50424.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain UbiA PF01040.18 EFC50425.1 - 9.9e-52 175.7 9.8 1.2e-51 175.4 9.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family TauE PF01925.19 EFC50425.1 - 6.3 6.4 13.3 2.1 7.9 6.7 2.8 2 2 0 2 2 2 0 Sulfite exporter TauE/SafE Atg14 PF10186.9 EFC50426.1 - 7.8e-11 41.6 12.3 1.3e-10 40.9 12.3 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Helicase_C PF00271.31 EFC50427.1 - 1.1e-22 80.5 1.5 1.5e-21 76.9 0.4 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC50427.1 - 5e-19 68.7 0.2 1.2e-17 64.2 0.0 2.7 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC50427.1 - 3.4e-05 23.9 3.5 4.9e-05 23.4 0.0 2.9 2 2 1 3 3 3 1 Type III restriction enzyme, res subunit DUF4783 PF16022.5 EFC50427.1 - 0.00055 20.1 0.2 0.0023 18.0 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4783) T2SSE PF00437.20 EFC50427.1 - 0.0093 15.1 0.1 0.026 13.6 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein Cupin_3 PF05899.12 EFC50428.1 - 2.5e-16 59.1 1.0 3.1e-16 58.8 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF861) cNMP_binding PF00027.29 EFC50428.1 - 0.00085 19.3 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 EFC50428.1 - 0.0029 17.3 0.1 0.0043 16.7 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 EFC50428.1 - 0.039 13.6 0.0 0.05 13.2 0.0 1.1 1 0 0 1 1 1 0 Cupin CCM2_C PF16545.5 EFC50429.1 - 0.0027 18.2 1.2 0.0099 16.4 0.0 2.4 2 1 1 3 3 3 1 Cerebral cavernous malformation protein, harmonin-homology TACC_C PF05010.14 EFC50429.1 - 0.0038 17.0 6.6 0.0038 17.0 6.6 2.0 2 1 0 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TPR_MLP1_2 PF07926.12 EFC50429.1 - 0.013 15.6 2.4 0.013 15.6 2.4 3.3 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 EFC50429.1 - 0.034 14.2 5.4 0.058 13.4 1.7 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 EFC50429.1 - 0.25 11.3 6.1 0.06 13.4 1.5 2.2 2 1 0 2 2 2 0 Laminin Domain II APG6_N PF17675.1 EFC50429.1 - 0.73 10.4 8.6 0.17 12.4 4.7 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region KLRAQ PF10205.9 EFC50429.1 - 0.89 9.8 7.8 0.35 11.1 4.4 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Tropomyosin PF00261.20 EFC50429.1 - 0.94 8.8 11.1 0.17 11.2 5.4 2.0 2 0 0 2 2 2 0 Tropomyosin FapA PF03961.13 EFC50429.1 - 1.7 7.1 9.4 0.072 11.7 3.5 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF713 PF05218.14 EFC50429.1 - 3.7 7.2 14.9 0.13 12.0 5.9 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF713) Jnk-SapK_ap_N PF09744.9 EFC50429.1 - 4.2 7.6 11.3 0.41 10.9 5.6 2.2 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 EFC50429.1 - 6.8 6.8 12.2 2.2 8.4 6.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMF_DNA_bd PF12329.8 EFC50429.1 - 9.9 6.2 17.5 0.12 12.4 9.0 2.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Tho2 PF11262.8 EFC50430.1 - 2.2e-41 142.0 17.8 4.2e-40 137.8 10.1 5.8 5 1 1 6 6 6 2 Transcription factor/nuclear export subunit protein 2 THOC2_N PF16134.5 EFC50430.1 - 1.7e-36 126.1 43.3 2.2e-25 89.4 16.2 5.8 2 2 2 4 4 4 2 THO complex subunit 2 N-terminus Thoc2 PF11732.8 EFC50430.1 - 2.3e-19 69.2 2.2 3.8e-19 68.5 0.1 2.5 2 0 0 2 2 2 1 Transcription- and export-related complex subunit CRAL_TRIO_2 PF13716.6 EFC50431.1 - 2.1e-33 115.4 1.5 2.4e-33 115.2 1.5 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 EFC50431.1 - 3.1e-10 40.0 3.5 5.3e-10 39.2 3.5 1.3 1 1 0 1 1 1 1 CRAL/TRIO domain Sec7_N PF12783.7 EFC50431.1 - 0.027 14.4 0.2 0.038 13.9 0.2 1.2 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Poty_coat PF00767.18 EFC50431.1 - 0.076 12.6 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Potyvirus coat protein DEAD PF00270.29 EFC50432.1 - 2.5e-30 105.6 5.2 3.3e-30 105.1 0.5 2.4 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50432.1 - 2e-26 92.5 0.1 6.1e-26 91.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50432.1 - 8.1e-05 22.7 0.7 0.00012 22.2 0.1 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 EFC50432.1 - 0.063 13.1 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 Helicase Glyco_transf_18 PF15024.6 EFC50433.1 - 2.8e-10 39.4 7.1 5e-10 38.6 7.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 18 NAD_synthase PF02540.17 EFC50434.1 - 9.7e-34 116.6 0.0 1.2e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 NAD synthase GTSE1_N PF15259.6 EFC50434.1 - 0.045 13.9 0.2 0.093 12.9 0.2 1.5 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 PAPS_reduct PF01507.19 EFC50434.1 - 0.12 12.4 0.0 0.54 10.3 0.0 2.0 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family tRNA_Me_trans PF03054.16 EFC50434.1 - 0.15 10.8 0.0 0.35 9.6 0.0 1.7 2 0 0 2 2 2 0 tRNA methyl transferase Elongin_A PF06881.11 EFC50435.1 - 4.1e-11 43.3 3.8 9.3e-11 42.2 3.8 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A SRP40_C PF05022.12 EFC50436.1 - 1.8e-18 67.1 1.5 1.8e-18 67.1 1.5 2.9 2 0 0 2 2 2 1 SRP40, C-terminal domain Zn_clus PF00172.18 EFC50437.1 - 6.2e-05 23.0 13.0 0.00011 22.2 13.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain B277 PF17623.2 EFC50437.1 - 0.011 14.8 0.0 0.025 13.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function LAGLIDADG_WhiA PF14527.6 EFC50437.1 - 0.027 14.5 0.5 0.11 12.5 0.1 2.3 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain DUF1266 PF06889.11 EFC50437.1 - 0.043 13.9 0.1 0.084 12.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) SHMT PF00464.19 EFC50438.1 - 1.7e-197 655.8 0.0 2.2e-197 655.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_1_2 PF00155.21 EFC50438.1 - 7.3e-08 32.0 0.0 1.5e-07 31.0 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 EFC50438.1 - 0.0036 16.3 0.6 0.52 9.2 0.1 2.9 2 1 0 2 2 2 2 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 EFC50438.1 - 0.037 13.4 0.1 0.085 12.1 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Comm PF15957.5 EFC50439.1 - 0.1 12.9 5.2 0.55 10.6 0.5 2.7 2 1 0 2 2 2 0 Commissureless LRR19-TM PF15176.6 EFC50439.1 - 0.9 9.6 3.4 14 5.8 0.1 3.0 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain DUF2663 PF10864.8 EFC50439.1 - 5.5 7.4 11.9 0.6 10.5 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) Arteri_Gl PF00951.18 EFC50441.1 - 2.1 8.1 6.2 2.5 7.9 6.2 1.1 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein DEAD PF00270.29 EFC50442.1 - 3.7e-32 111.5 0.1 7.1e-32 110.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50442.1 - 4.4e-22 78.5 0.4 2.7e-21 76.0 0.1 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 EFC50442.1 - 1.3e-08 35.1 0.2 6.4e-08 32.8 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Met_synt_B12 PF02965.17 EFC50443.1 - 1.7e-114 381.9 0.0 2.8e-114 381.2 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 EFC50443.1 - 1.5e-78 264.3 0.2 3.8e-78 263.0 0.2 1.7 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 EFC50443.1 - 2.2e-57 194.5 0.2 2.9e-56 190.9 0.2 2.6 3 0 0 3 3 3 1 Pterin binding enzyme B12-binding_2 PF02607.17 EFC50443.1 - 3.5e-25 88.2 0.1 2.2e-24 85.7 0.0 2.5 3 0 0 3 3 3 1 B12 binding domain B12-binding PF02310.19 EFC50443.1 - 3.4e-18 65.8 0.2 1.8e-17 63.5 0.1 2.3 2 0 0 2 2 2 1 B12 binding domain WHIM1 PF15612.6 EFC50443.1 - 0.013 15.0 0.1 0.031 13.8 0.1 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 CdhD PF03599.16 EFC50443.1 - 0.037 12.7 0.2 0.07 11.8 0.2 1.3 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase delta subunit DUF2207 PF09972.9 EFC50444.1 - 0.018 13.8 0.1 0.019 13.7 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5542 PF17696.1 EFC50444.1 - 0.043 13.9 0.8 0.07 13.3 0.1 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5542) KELK PF15796.5 EFC50444.1 - 0.064 13.7 0.4 0.46 11.0 0.6 2.0 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Use1 PF09753.9 EFC50444.1 - 0.08 12.7 3.2 0.14 11.9 3.2 1.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 L27_N PF09060.10 EFC50444.1 - 0.14 12.3 0.3 0.14 12.3 0.3 1.6 2 0 0 2 2 2 0 L27_N HemY_N PF07219.13 EFC50444.1 - 0.81 9.9 3.4 6.5 7.0 2.5 2.1 2 0 0 2 2 2 0 HemY protein N-terminus Ribosomal_L7Ae PF01248.26 EFC50445.1 - 5.7e-09 35.6 1.5 1.2e-08 34.6 0.3 2.2 2 0 0 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RPAP1_C PF08620.10 EFC50446.1 - 6.9e-21 74.1 0.0 1.7e-20 72.9 0.0 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 EFC50446.1 - 4.2e-12 45.6 6.0 4.2e-12 45.6 6.0 2.7 2 0 0 2 2 2 1 RPAP1-like, N-terminal Kinesin PF00225.23 EFC50447.1 - 3.3e-50 170.9 3.8 7.3e-50 169.8 3.8 1.5 1 0 0 1 1 1 1 Kinesin motor domain MORN PF02493.20 EFC50447.1 - 6.8e-23 79.2 54.2 1.1e-05 25.1 2.4 8.0 8 0 0 8 8 8 6 MORN repeat DUF4483 PF14825.6 EFC50447.1 - 7.7e-23 81.0 1.4 1.8e-22 79.8 1.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4483) Microtub_bd PF16796.5 EFC50447.1 - 6.7e-14 52.1 0.2 6.7e-14 52.1 0.2 2.7 3 0 0 3 3 3 1 Microtubule binding Ufm1 PF03671.14 EFC50448.1 - 2.2e-40 136.6 0.1 2.5e-40 136.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin fold modifier 1 protein Rad60-SLD PF11976.8 EFC50448.1 - 0.0074 16.1 0.0 0.0097 15.7 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TCR PF03638.15 EFC50449.1 - 1.3e-11 44.6 27.1 2.1e-11 44.0 27.1 1.3 1 0 0 1 1 1 1 Tesmin/TSO1-like CXC domain, cysteine-rich domain DUF4611 PF15387.6 EFC50449.1 - 0.031 14.5 4.3 0.079 13.2 1.8 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) MSL2-CXC PF16682.5 EFC50449.1 - 0.37 10.9 23.3 0.86 9.8 23.3 1.5 1 0 0 1 1 1 0 CXC domain of E3 ubiquitin-protein ligase MSL2 Mis12 PF05859.12 EFC50450.1 - 0.0002 21.4 4.3 0.0002 21.4 4.3 2.0 1 1 1 2 2 2 1 Mis12 protein PhaP_Bmeg PF09602.10 EFC50450.1 - 0.0091 15.9 15.4 0.015 15.2 0.3 3.1 1 1 2 3 3 3 2 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF1116 PF06545.11 EFC50450.1 - 0.023 14.2 0.0 0.04 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1116) GlutR_dimer PF00745.20 EFC50450.1 - 0.15 12.5 1.8 2.4 8.7 0.0 3.1 3 1 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain LOH1CR12 PF10158.9 EFC50450.1 - 0.39 10.7 7.2 0.71 9.9 0.8 3.0 1 1 1 2 2 2 0 Tumour suppressor protein 7TMR-HDED PF07697.11 EFC50450.1 - 0.79 9.8 8.7 6.1 6.9 6.1 2.4 1 1 1 2 2 2 0 7TM-HD extracellular PRP9_N PF16958.5 EFC50450.1 - 1.2 9.2 13.8 0.7 9.9 10.0 2.4 1 1 0 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus ABC_tran PF00005.27 EFC50451.1 - 1.9e-38 132.0 0.4 7.3e-38 130.2 0.0 2.1 2 1 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 EFC50451.1 - 2.5e-36 125.7 12.2 3.2e-36 125.4 12.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 EFC50451.1 - 1.1e-07 31.5 0.4 5.1e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 EFC50451.1 - 2.1e-05 24.4 0.6 0.00031 20.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 EFC50451.1 - 0.00088 19.0 0.0 0.0021 17.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 EFC50451.1 - 0.0018 18.8 0.6 0.023 15.2 0.1 2.5 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 EFC50451.1 - 0.0032 16.7 0.1 0.0062 15.7 0.1 1.4 1 0 0 1 1 1 1 G-protein alpha subunit AAA_21 PF13304.6 EFC50451.1 - 0.0048 16.7 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 EFC50451.1 - 0.0092 16.3 0.1 0.043 14.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC50451.1 - 0.0093 16.4 0.0 0.026 14.9 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 EFC50451.1 - 0.013 15.4 0.1 0.053 13.4 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 EFC50451.1 - 0.021 15.2 0.2 3.8 7.9 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 EFC50451.1 - 0.048 13.6 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_30 PF13604.6 EFC50451.1 - 0.066 12.9 0.0 0.46 10.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF1358 PF07096.11 EFC50451.1 - 0.073 13.1 0.4 0.81 9.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1358) AAA_18 PF13238.6 EFC50451.1 - 0.14 12.7 0.0 0.41 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 EFC50451.1 - 0.26 10.6 2.9 0.45 9.8 0.0 2.5 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region GWT1 PF06423.12 EFC50452.1 - 8.7e-36 123.3 8.9 8.7e-36 123.3 8.9 4.0 2 1 1 3 3 3 1 GWT1 MscL PF01741.18 EFC50452.1 - 0.43 10.9 12.8 3.1 8.1 0.9 4.1 3 2 1 4 4 4 0 Large-conductance mechanosensitive channel, MscL Hus1 PF04005.12 EFC50453.1 - 3.2e-54 184.0 4.6 5.4e-54 183.3 4.6 1.3 1 1 0 1 1 1 1 Hus1-like protein EPO_TPO PF00758.18 EFC50453.1 - 0.025 14.6 2.7 1.2 9.2 0.1 2.2 2 0 0 2 2 2 0 Erythropoietin/thrombopoietin S-AdoMet_synt_M PF02772.16 EFC50453.1 - 1.5 9.1 5.3 3.1 8.1 0.9 2.3 1 1 1 2 2 2 0 S-adenosylmethionine synthetase, central domain Peptidase_M48 PF01435.18 EFC50454.1 - 4.5e-32 111.4 0.4 1e-31 110.3 0.4 1.6 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 EFC50454.1 - 0.0015 17.8 0.0 0.011 15.0 0.0 2.1 1 1 1 2 2 2 1 BlaR1 peptidase M56 PDR_assoc PF08370.11 EFC50454.1 - 1.5 8.6 0.0 1.5 8.6 0.0 3.0 4 0 0 4 4 4 0 Plant PDR ABC transporter associated Peptidase_S24 PF00717.23 EFC50455.1 - 5.4e-09 35.9 0.5 1e-07 31.8 0.5 2.2 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 EFC50455.1 - 7.1e-05 22.6 0.0 0.0016 18.3 0.0 2.3 2 1 0 2 2 2 1 Signal peptidase, peptidase S26 Sec1 PF00995.23 EFC50458.1 - 7.7e-104 349.0 15.2 9.6e-104 348.7 15.2 1.1 1 0 0 1 1 1 1 Sec1 family ACD PF16671.5 EFC50458.1 - 0.012 13.9 0.1 0.021 13.2 0.1 1.3 1 0 0 1 1 1 0 Actin cross-linking domain Amidase PF01425.21 EFC50458.1 - 0.045 12.7 0.4 1.3 7.8 0.6 2.1 2 0 0 2 2 2 0 Amidase XFP_N PF09364.10 EFC50458.1 - 0.072 11.9 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 XFP N-terminal domain Hydrolase_6 PF13344.6 EFC50458.1 - 0.2 11.8 1.5 0.56 10.4 0.4 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase BRCT PF00533.26 EFC50459.1 - 0.043 14.2 0.6 0.33 11.3 0.0 2.9 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Tugs PF17840.1 EFC50459.1 - 2.7 8.2 6.2 22 5.4 0.1 3.9 3 0 0 3 3 3 0 Tethering Ubl4a to BAGS domain MMgT PF10270.9 EFC50460.1 - 0.0004 20.7 0.1 0.00058 20.2 0.1 1.3 1 1 0 1 1 1 1 Membrane magnesium transporter DUF3592 PF12158.8 EFC50462.1 - 0.0046 17.0 0.0 0.014 15.4 0.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3592) RNB PF00773.19 EFC50463.1 - 1.1e-30 107.1 9.2 2.1e-27 96.3 2.5 4.3 3 2 1 4 4 4 2 RNB domain FlgN PF05130.12 EFC50463.1 - 0.78 10.2 5.1 15 6.0 0.2 3.0 2 0 0 2 2 2 0 FlgN protein T6PP_N PF18572.1 EFC50464.1 - 0.0097 15.7 0.8 0.022 14.6 0.2 2.0 1 1 1 2 2 2 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF1980 PF09323.10 EFC50464.1 - 0.16 11.9 4.7 0.044 13.7 1.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Peptidase_C2 PF00648.21 EFC50465.1 - 5.5e-37 127.4 1.9 5.5e-37 127.4 1.9 4.0 2 2 1 3 3 3 1 Calpain family cysteine protease RIIa PF02197.17 EFC50467.1 - 7.2e-10 38.4 0.0 1.7e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit EF-hand_7 PF13499.6 EFC50467.1 - 0.059 13.8 0.6 0.55 10.7 0.1 2.6 1 1 1 2 2 2 0 EF-hand domain pair XRN_N PF03159.18 EFC50468.1 - 4.1e-26 91.9 0.0 1.2e-14 54.3 0.0 2.3 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus GAS PF13851.6 EFC50469.1 - 4.4e-72 241.6 37.2 4.4e-72 241.6 37.2 3.5 2 1 1 3 3 3 1 Growth-arrest specific micro-tubule binding Tyrosinase PF00264.20 EFC50469.1 - 6 7.1 11.2 1.2e+02 2.8 10.0 2.7 1 1 0 1 1 1 0 Common central domain of tyrosinase Med6 PF04934.14 EFC50470.1 - 2.3e-27 95.4 0.2 3.8e-27 94.7 0.2 1.3 1 0 0 1 1 1 1 MED6 mediator sub complex component Rep_3 PF01051.21 EFC50471.1 - 0.022 14.6 3.6 0.025 14.4 0.4 2.0 1 1 1 2 2 2 0 Initiator Replication protein Gly_radical PF01228.21 EFC50472.1 - 0.86 10.2 8.8 0.63 10.6 2.7 3.1 3 0 0 3 3 3 0 Glycine radical Pkinase PF00069.25 EFC50473.1 - 2.8e-72 243.3 0.0 3.2e-72 243.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50473.1 - 6.2e-29 101.1 0.1 8.2e-29 100.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC50473.1 - 0.0022 17.3 0.0 0.0032 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 EFC50473.1 - 0.014 14.4 0.2 0.023 13.8 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 EFC50473.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 EFC50473.1 - 0.082 12.5 0.4 1.8 8.1 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FAP206 PF12018.8 EFC50475.1 - 0.013 15.1 6.9 0.023 14.2 6.9 1.6 1 1 0 1 1 1 0 Domain of unknown function zf-CRD PF17979.1 EFC50475.1 - 3 7.9 6.7 1.7 8.7 0.5 2.4 2 1 0 2 2 2 0 Cysteine rich domain with multizinc binding regions Serpin PF00079.20 EFC50477.1 - 1.9e-81 274.2 12.9 2.2e-81 274.1 12.9 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) YfkD PF14167.6 EFC50477.1 - 0.022 14.0 1.5 0.54 9.4 0.2 2.2 2 0 0 2 2 2 0 YfkD-like protein tRNA-synt_1g PF09334.11 EFC50478.1 - 7.5e-106 354.2 0.9 9.7e-106 353.8 0.9 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA_bind PF01588.20 EFC50478.1 - 8e-24 83.6 0.2 1.5e-23 82.7 0.2 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain tRNA-synt_1 PF00133.22 EFC50478.1 - 2.1e-11 42.8 2.3 3.4e-06 25.6 0.1 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 EFC50478.1 - 0.0059 16.0 0.0 0.0087 15.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain CBFD_NFYB_HMF PF00808.23 EFC50479.1 - 4e-16 59.0 1.0 6.6e-16 58.4 1.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 EFC50479.1 - 0.0079 16.6 0.4 0.0079 16.6 0.4 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Zn_clus PF00172.18 EFC50481.1 - 4.9e-05 23.4 12.5 9.1e-05 22.5 12.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lectin_N PF03954.14 EFC50482.1 - 0.096 12.4 2.0 0.22 11.3 2.0 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Form_Nir_trans PF01226.17 EFC50483.1 - 1.9e-69 233.6 26.9 2.3e-69 233.3 26.9 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter DUF1295 PF06966.12 EFC50483.1 - 0.013 15.0 1.3 0.024 14.2 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Ost5 PF05251.12 EFC50483.1 - 0.14 12.4 11.6 2.1 8.7 0.1 3.7 2 1 1 3 3 3 0 Oligosaccharyltransferase subunit 5 Ndc1_Nup PF09531.10 EFC50483.1 - 4.5 5.8 7.1 6.2 5.4 7.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup IFT46_B_C PF12317.8 EFC50484.1 - 0.0034 17.2 1.9 0.0034 17.2 1.9 2.4 2 0 0 2 2 2 2 Intraflagellar transport complex B protein 46 C terminal DEAD PF00270.29 EFC50485.1 - 1.4e-46 158.5 0.1 4.1e-44 150.4 0.0 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50485.1 - 6.5e-31 106.9 1.1 1.9e-28 99.0 0.0 3.1 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 EFC50485.1 - 1.8e-06 27.4 2.6 1.8e-06 27.4 0.0 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase DBP10CT PF08147.12 EFC50485.1 - 0.0025 18.0 8.1 0.0025 18.0 8.1 3.6 3 0 0 3 3 3 1 DBP10CT (NUC160) domain ANAPC4_WD40 PF12894.7 EFC50486.1 - 6.4e-11 42.4 0.0 0.0022 18.3 0.0 4.9 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC50486.1 - 5.5e-07 30.2 1.3 0.25 12.3 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 EFC50486.1 - 0.00015 20.4 0.5 0.00031 19.4 0.5 1.4 1 0 0 1 1 1 1 Cytochrome D1 heme domain Hira PF07569.11 EFC50486.1 - 0.0081 15.9 0.1 10 5.8 0.0 3.3 2 1 1 3 3 3 2 TUP1-like enhancer of split Actin PF00022.19 EFC50487.1 - 1.8e-100 336.4 0.0 3.2e-100 335.6 0.0 1.4 1 1 0 1 1 1 1 Actin N-Term_TEN PF11474.8 EFC50487.1 - 0.0089 15.6 0.1 0.016 14.8 0.1 1.3 1 0 0 1 1 1 1 Telomerase reverse transcriptase TEN domain Aminotran_1_2 PF00155.21 EFC50488.1 - 8.2e-79 265.4 0.0 9.4e-79 265.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DUF2691 PF10903.8 EFC50488.1 - 0.064 13.1 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2691) IF2_N PF04760.15 EFC50488.1 - 0.2 11.5 1.2 2.9 7.8 1.2 2.4 1 1 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Beach PF02138.18 EFC50489.1 - 2.2e-113 378.2 0.5 6.5e-113 376.7 0.5 1.9 1 0 0 1 1 1 1 Beige/BEACH domain DUF4704 PF15787.5 EFC50489.1 - 2.2e-86 289.6 5.0 2.2e-86 289.6 5.0 3.9 4 1 0 4 4 4 1 Domain of unknown function (DUF4704) PH_BEACH PF14844.6 EFC50489.1 - 1.1e-22 80.0 0.1 6.9e-22 77.4 0.1 2.6 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 EFC50489.1 - 3.3e-09 37.2 7.3 0.00078 20.2 0.3 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Laminin_G_3 PF13385.6 EFC50489.1 - 2.2e-08 34.4 0.0 5.8e-05 23.3 0.0 3.2 1 1 1 2 2 2 2 Concanavalin A-like lectin/glucanases superfamily DUF4800 PF16057.5 EFC50489.1 - 3.1e-06 26.7 3.2 1.5e-05 24.4 3.2 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4800) DUF1088 PF06469.11 EFC50489.1 - 0.00055 19.6 3.3 0.003 17.2 2.3 2.3 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1088) LOB PF03195.14 EFC50489.1 - 0.071 13.7 0.0 2.5 8.7 0.0 2.7 2 0 0 2 2 2 0 Lateral organ boundaries (LOB) domain SoDot-IcmSS PF16848.5 EFC50490.1 - 0.04 13.9 1.5 0.084 12.8 1.5 1.5 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative C2-C2_1 PF11618.8 EFC50491.1 - 0.29 11.2 3.0 0.44 10.6 0.4 2.4 2 1 1 3 3 3 0 First C2 domain of RPGR-interacting protein 1 HisKA PF00512.25 EFC50491.1 - 0.47 10.5 5.4 0.26 11.4 0.4 3.1 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain HALZ PF02183.18 EFC50491.1 - 1.9 8.8 21.1 0.43 10.8 1.4 4.9 5 0 0 5 5 5 0 Homeobox associated leucine zipper TPR_1 PF00515.28 EFC50492.1 - 9e-31 104.4 25.7 1.7e-07 30.7 0.1 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50492.1 - 1.4e-30 102.9 19.7 9.3e-05 22.3 0.0 11.1 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50492.1 - 1.3e-18 67.0 13.5 0.0032 17.7 0.0 8.2 4 3 3 7 7 7 4 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50492.1 - 4e-18 65.4 25.9 9.7e-06 25.7 0.0 6.9 3 3 4 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 EFC50492.1 - 6.2e-18 65.1 0.2 0.00084 19.8 0.0 6.8 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50492.1 - 9e-16 57.3 9.5 2.5e-05 23.9 0.1 8.4 5 2 4 9 9 9 4 TPR repeat TPR_8 PF13181.6 EFC50492.1 - 1.2e-13 50.0 25.5 0.013 15.7 0.0 9.9 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50492.1 - 2.5e-12 47.2 0.0 0.00018 22.1 0.0 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50492.1 - 1.5e-10 41.0 0.1 19 6.4 0.4 8.4 4 2 5 9 9 8 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50492.1 - 1.9e-09 37.2 9.3 0.47 11.0 0.1 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50492.1 - 5.4e-07 29.2 12.1 0.012 15.6 0.0 7.9 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50492.1 - 3.1e-06 27.5 8.7 10 7.0 0.0 8.1 9 1 0 9 9 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 EFC50492.1 - 7.4e-05 22.8 0.0 0.33 11.1 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50492.1 - 0.0054 16.6 4.3 1.5e+02 2.5 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat FAT PF02259.23 EFC50492.1 - 0.0089 15.3 2.2 0.011 14.9 0.3 2.1 2 1 0 2 2 2 1 FAT domain Fis1_TPR_C PF14853.6 EFC50492.1 - 0.029 14.5 5.4 0.054 13.6 0.5 3.6 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 EFC50492.1 - 0.11 12.5 1.6 8.7 6.5 0.1 3.6 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain HrpB1_HrpK PF09613.10 EFC50492.1 - 0.12 12.1 0.0 7.4 6.2 0.0 2.8 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) SRP_TPR_like PF17004.5 EFC50492.1 - 0.47 10.5 13.7 0.65 10.0 0.2 4.3 3 1 1 4 4 4 0 Putative TPR-like repeat Ras PF00071.22 EFC50493.1 - 2.9e-60 202.6 0.1 3.4e-60 202.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50493.1 - 4e-34 117.4 0.0 6.3e-34 116.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50493.1 - 9.7e-12 44.7 0.0 1.2e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 EFC50493.1 - 5.2e-05 23.3 0.0 7.4e-05 22.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 EFC50493.1 - 0.0002 21.3 0.1 0.65 9.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 EFC50493.1 - 0.0042 16.6 0.0 0.0092 15.5 0.0 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC50493.1 - 0.0056 16.1 0.0 0.0076 15.6 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 EFC50493.1 - 0.059 13.8 0.2 0.11 12.9 0.2 1.5 1 1 0 1 1 1 0 AAA ATPase domain Ribonucleas_3_3 PF14622.6 EFC50494.1 - 3e-16 59.7 0.9 1.1e-13 51.5 0.9 2.4 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 EFC50494.1 - 0.00011 22.8 0.0 0.00032 21.3 0.0 1.9 1 0 0 1 1 1 1 Ribonuclease III domain DUF810 PF05664.11 EFC50496.1 - 2.2e-09 36.5 4.1 4.2e-09 35.5 4.1 1.4 1 0 0 1 1 1 1 Plant family of unknown function (DUF810) Thioredoxin_12 PF18400.1 EFC50496.1 - 0.061 13.2 0.2 0.36 10.7 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin-like domain MRP-S26 PF14943.6 EFC50497.1 - 1.5 8.7 9.7 0.36 10.7 5.4 2.0 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 Utp21 PF04192.12 EFC50498.1 - 3.8e-27 95.3 6.9 3.8e-27 95.3 6.9 2.0 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 EFC50498.1 - 2.7e-18 66.0 7.7 1.6e-05 25.6 0.4 7.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50498.1 - 8.1e-13 48.5 0.2 0.00086 19.6 0.0 5.8 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain ExbD PF02472.16 EFC50498.1 - 0.97 9.6 4.9 31 4.7 5.2 2.8 1 1 1 2 2 2 0 Biopolymer transport protein ExbD/TolR U3_assoc_6 PF08640.11 EFC50499.1 - 8.8e-09 35.3 2.0 8.8e-09 35.3 2.0 3.2 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 NRDE-2 PF08424.10 EFC50499.1 - 0.64 9.1 11.5 1.3 8.1 1.6 3.9 3 2 0 3 3 3 0 NRDE-2, necessary for RNA interference FANCI_S2 PF14676.6 EFC50499.1 - 1.8 8.9 8.8 0.99 9.7 1.0 3.6 3 1 1 4 4 4 0 FANCI solenoid 2 DUF3429 PF11911.8 EFC50500.1 - 5.6e-11 42.9 11.5 5.3e-10 39.7 11.5 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3429) TIP_N PF12457.8 EFC50500.1 - 0.055 13.9 0.4 1.4 9.3 0.2 2.2 2 0 0 2 2 2 0 Tuftelin interacting protein N terminal LSM PF01423.22 EFC50501.1 - 9e-17 60.5 0.3 1.2e-16 60.1 0.3 1.2 1 0 0 1 1 1 1 LSM domain HNOB PF07700.15 EFC50501.1 - 0.14 12.1 0.1 0.17 11.8 0.1 1.1 1 0 0 1 1 1 0 Haem-NO-binding Pro_isomerase PF00160.21 EFC50502.1 - 8e-47 159.4 0.3 9.5e-47 159.2 0.3 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD H_PPase PF03030.16 EFC50503.1 - 2.4e-70 238.0 23.4 7e-70 236.4 23.4 1.6 1 1 0 1 1 1 1 Inorganic H+ pyrophosphatase LapA_dom PF06305.11 EFC50503.1 - 0.59 10.0 0.0 0.59 10.0 0.0 7.2 7 2 1 8 8 8 0 Lipopolysaccharide assembly protein A domain DUF1279 PF06916.13 EFC50503.1 - 8.3 7.0 8.2 23 5.6 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1279) Glyco_hydro_31 PF01055.26 EFC50504.1 - 3.1e-137 458.4 4.3 5.1e-137 457.7 4.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 EFC50504.1 - 9.9e-14 51.4 0.2 2.6e-13 50.1 0.2 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 EFC50504.1 - 0.0096 16.2 1.9 0.021 15.1 0.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) Dynein_light PF01221.18 EFC50505.1 - 1.9e-42 143.5 1.3 2.1e-42 143.3 1.3 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 ANAPC4_WD40 PF12894.7 EFC50506.1 - 1.5e-06 28.4 0.2 0.1 12.9 0.1 3.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC50506.1 - 9.9e-05 23.0 2.5 0.12 13.3 0.1 4.4 5 0 0 5 5 5 1 WD domain, G-beta repeat PQQ_3 PF13570.6 EFC50506.1 - 0.0019 18.6 2.3 3.2 8.4 0.1 3.9 4 0 0 4 4 4 2 PQQ-like domain PQQ_2 PF13360.6 EFC50506.1 - 0.031 13.9 0.2 0.29 10.7 0.1 2.4 1 1 0 1 1 1 0 PQQ-like domain GxDLY PF14607.6 EFC50506.1 - 0.11 12.2 0.1 5 6.9 0.1 2.3 2 0 0 2 2 2 0 N-terminus of Esterase_SGNH_hydro-type DUF4160 PF13711.6 EFC50507.1 - 0.42 11.0 3.1 0.85 10.0 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) Lipoprotein_6 PF01441.19 EFC50507.1 - 0.55 10.2 14.2 3.8 7.5 1.6 2.4 2 0 0 2 2 2 0 Lipoprotein Peptidase_M14 PF00246.24 EFC50508.1 - 2e-16 60.7 0.0 7.9e-16 58.7 0.0 2.0 1 1 0 1 1 1 1 Zinc carboxypeptidase Pepdidase_M14_N PF18027.1 EFC50508.1 - 1.3e-14 54.4 1.0 3.3e-14 53.1 1.0 1.7 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain LRR_6 PF13516.6 EFC50509.1 - 4e-14 51.4 22.6 0.18 12.0 0.1 9.8 10 1 0 10 10 10 5 Leucine Rich repeat LRR_8 PF13855.6 EFC50509.1 - 2.9e-13 49.4 32.3 2.7e-07 30.3 0.3 7.1 5 2 2 7 7 7 4 Leucine rich repeat LRR_4 PF12799.7 EFC50509.1 - 3.8e-11 43.0 43.3 0.00095 19.5 0.4 9.9 4 1 7 11 11 11 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC50509.1 - 0.0007 19.8 15.8 7.6 7.5 0.5 6.7 6 0 0 6 6 6 2 Leucine Rich Repeat F-box PF00646.33 EFC50509.1 - 0.017 15.0 0.5 0.35 10.8 0.1 2.4 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 EFC50509.1 - 0.13 12.1 0.1 0.26 11.2 0.1 1.5 1 0 0 1 1 1 0 F-box-like FA_hydroxylase PF04116.13 EFC50510.1 - 2.7e-27 95.7 18.0 2.7e-27 95.7 18.0 1.9 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily FA_hydroxylase PF04116.13 EFC50511.1 - 1.2e-25 90.4 15.4 1.2e-25 90.4 15.4 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily Chlam_OMP PF01308.17 EFC50511.1 - 0.13 11.0 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Chlamydia major outer membrane protein LRR_6 PF13516.6 EFC50512.1 - 9.7e-30 100.1 21.1 1.9e-06 27.5 0.0 10.9 11 0 0 11 11 11 7 Leucine Rich repeat LRR_8 PF13855.6 EFC50512.1 - 2.2e-17 62.5 20.0 0.00013 21.7 0.7 7.5 5 3 2 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 EFC50512.1 - 2.3e-16 59.6 26.6 0.0029 18.0 0.0 8.8 1 1 8 10 10 10 8 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 EFC50512.1 - 1.2e-11 43.5 17.6 0.73 10.6 0.0 9.9 9 1 1 10 10 10 3 Leucine Rich Repeat RecO_N PF11967.8 EFC50512.1 - 0.089 12.8 0.0 0.51 10.3 0.0 2.2 2 0 0 2 2 2 0 Recombination protein O N terminal Ham1p_like PF01725.16 EFC50513.1 - 1.5e-45 155.4 0.0 1.7e-45 155.2 0.0 1.1 1 0 0 1 1 1 1 Ham1 family SIT PF15330.6 EFC50514.1 - 0.077 13.4 1.4 0.33 11.4 1.5 2.2 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT AtpR PF12966.7 EFC50514.1 - 0.22 12.0 0.2 0.22 12.0 0.2 2.3 2 0 0 2 2 2 0 N-ATPase, AtpR subunit Adipogenin PF15202.6 EFC50514.1 - 1.3 9.1 6.2 1.2 9.2 0.2 3.2 3 0 0 3 3 3 0 Adipogenin MAT1 PF06391.13 EFC50515.1 - 0.00032 20.6 9.0 0.00034 20.5 9.0 1.2 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 FliW PF02623.15 EFC50515.1 - 0.013 15.4 0.5 0.022 14.6 0.4 1.5 2 0 0 2 2 2 0 FliW protein Paf1 PF03985.13 EFC50515.1 - 0.28 10.1 13.3 0.34 9.8 13.3 1.1 1 0 0 1 1 1 0 Paf1 Membralin PF09746.9 EFC50515.1 - 0.56 9.2 5.5 0.65 9.0 5.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF1635 PF07795.11 EFC50515.1 - 0.64 9.8 10.8 0.17 11.7 6.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) Borrelia_P83 PF05262.11 EFC50515.1 - 1.2 7.5 12.4 1.5 7.2 12.4 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Ribonuclease_3 PF00636.26 EFC50516.1 - 0.0083 16.7 0.1 0.018 15.6 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease III domain TBPIP PF07106.13 EFC50517.1 - 7.2e-13 48.3 1.1 1.8e-12 47.0 0.2 2.1 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain LZ3wCH PF18517.1 EFC50517.1 - 3.3e-06 27.1 1.7 3.3e-06 27.1 1.7 2.2 3 0 0 3 3 2 1 Leucine zipper with capping helix domain Cluap1 PF10234.9 EFC50517.1 - 0.012 15.0 13.5 0.015 14.7 13.5 1.3 1 1 0 1 1 1 0 Clusterin-associated protein-1 DUF4407 PF14362.6 EFC50517.1 - 0.19 11.1 5.3 0.25 10.7 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4795 PF16043.5 EFC50517.1 - 0.21 11.2 14.9 0.068 12.8 12.5 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Virulence_fact PF13769.6 EFC50517.1 - 0.24 11.6 2.8 0.29 11.4 0.2 2.2 2 0 0 2 2 2 0 Virulence factor DIRP PF06584.13 EFC50517.1 - 0.31 11.3 4.8 4.7 7.5 0.3 2.9 1 1 2 3 3 3 0 DIRP AAA_32 PF13654.6 EFC50517.1 - 0.45 9.2 10.2 0.66 8.7 10.2 1.4 1 1 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 EFC50517.1 - 0.58 9.7 5.2 0.74 9.3 5.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit MIP-T3_C PF17749.1 EFC50517.1 - 0.64 10.0 13.2 2.6 8.0 2.2 2.3 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DivIC PF04977.15 EFC50517.1 - 0.72 9.7 11.5 1.1 9.1 9.7 2.2 1 1 1 2 2 2 0 Septum formation initiator Snapin_Pallidin PF14712.6 EFC50517.1 - 0.99 9.9 10.0 0.65 10.5 7.4 2.0 1 1 1 2 2 2 0 Snapin/Pallidin BBS1 PF14779.6 EFC50517.1 - 1.5 8.2 8.7 1.1 8.6 2.7 2.1 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 1 DUF2680 PF10925.8 EFC50517.1 - 2.2 8.4 10.2 0.2 11.7 1.9 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2680) ALMT PF11744.8 EFC50517.1 - 2.3 7.0 6.5 2.6 6.8 6.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FapA PF03961.13 EFC50517.1 - 4.7 5.7 16.4 0.82 8.2 9.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A COG2 PF06148.11 EFC50517.1 - 4.9 7.2 8.5 13 5.9 7.1 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 UPF0242 PF06785.11 EFC50517.1 - 5.3 7.1 16.7 13 5.9 16.6 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 EFC50517.1 - 5.6 7.7 10.5 2.6 8.7 6.7 2.3 1 1 2 3 3 3 0 Initiation control protein YabA OmpH PF03938.14 EFC50517.1 - 6.1 7.2 16.0 20 5.5 6.4 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4140 PF13600.6 EFC50517.1 - 7.7 7.0 10.0 0.5 10.8 1.7 2.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) V_ATPase_I PF01496.19 EFC50517.1 - 7.8 4.3 9.4 15 3.3 9.4 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.11 EFC50517.1 - 8.8 6.8 8.3 2.8 8.4 3.4 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Spc24 PF08286.11 EFC50517.1 - 9.2 6.6 12.4 11 6.3 3.4 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 eIF3_N PF09440.10 EFC50517.1 - 9.6 6.7 11.4 5.7 7.4 7.9 2.2 2 1 0 2 2 2 0 eIF3 subunit 6 N terminal domain CDT1_C PF16679.5 EFC50518.1 - 3.1e-07 30.7 1.0 8.2e-07 29.4 1.0 1.8 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain Dickkopf_N PF04706.12 EFC50519.1 - 0.0081 16.6 4.6 0.0081 16.6 4.6 7.9 7 2 1 9 9 9 2 Dickkopf N-terminal cysteine-rich region EB PF01683.18 EFC50519.1 - 0.014 15.7 17.0 0.026 14.8 4.3 7.2 2 1 3 5 5 5 0 EB module PhetRS_B1 PF18262.1 EFC50520.1 - 0.1 12.8 1.2 2.6 8.3 0.2 3.0 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain Guanylate_cyc PF00211.20 EFC50521.1 - 1.9e-49 167.7 0.6 4e-49 166.7 0.6 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS PF00989.25 EFC50521.1 - 4.1e-14 52.5 0.0 4.9e-06 26.5 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 EFC50521.1 - 2.2e-10 40.7 0.6 0.00021 21.5 0.0 2.8 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 EFC50521.1 - 0.049 13.7 0.0 18 5.5 0.0 2.5 2 0 0 2 2 2 0 PAS domain Pox_MCEL PF03291.16 EFC50522.1 - 5.3e-70 236.2 1.3 2.1e-69 234.2 1.3 1.7 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 EFC50522.1 - 4e-09 37.1 0.0 1.3e-08 35.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC50522.1 - 1.9e-07 31.8 0.0 4.1e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC50522.1 - 6.5e-07 29.9 0.0 1.2e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC50522.1 - 2e-06 27.7 0.0 3.2e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC50522.1 - 1.1e-05 25.4 0.0 1.6e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 EFC50522.1 - 0.0018 17.9 0.0 0.015 14.9 0.0 2.2 3 0 0 3 3 3 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 EFC50522.1 - 0.038 13.4 0.0 0.59 9.6 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase 2OG-FeII_Oxy_2 PF13532.6 EFC50523.1 - 1.7e-18 67.6 0.0 2.4e-18 67.1 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 EFC50523.1 - 0.07 14.0 0.0 0.14 13.0 0.0 1.5 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily DUF1201 PF06716.11 EFC50524.1 - 0.035 14.1 0.3 0.088 12.8 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) DUF4234 PF14018.6 EFC50524.1 - 0.084 13.0 0.4 0.38 10.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4234) Potass_KdpF PF09604.10 EFC50524.1 - 0.11 12.5 4.5 0.17 11.9 4.5 1.3 1 0 0 1 1 1 0 F subunit of K+-transporting ATPase (Potass_KdpF) RIC3 PF15361.6 EFC50524.1 - 0.2 12.0 2.5 0.43 11.0 2.2 1.7 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF5383 PF17355.2 EFC50524.1 - 0.59 10.5 9.0 3 8.2 0.0 3.5 2 1 1 3 3 3 0 Family of unknown function (DUF5383) Misat_Tub_SegII PF10644.9 EFC50525.1 - 1.4e-29 102.8 1.5 1.4e-29 102.8 1.5 2.2 1 1 1 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 EFC50525.1 - 1.1e-19 70.9 0.3 5.2e-19 68.6 0.2 2.2 2 1 0 2 2 2 1 Tubulin domain Tubulin PF00091.25 EFC50525.1 - 0.0007 19.8 0.3 0.7 10.1 0.6 2.9 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Actin PF00022.19 EFC50526.1 - 1.2e-103 346.9 0.0 9.6e-103 343.9 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 EFC50526.1 - 0.029 13.2 0.0 0.037 12.8 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein SLED PF12140.8 EFC50527.1 - 0.052 14.1 1.5 0.76 10.3 0.4 3.0 2 1 0 2 2 2 0 SLED domain MSA-2c PF12238.8 EFC50527.1 - 0.16 11.9 4.6 0.05 13.6 1.2 1.9 2 0 0 2 2 2 0 Merozoite surface antigen 2c Csm1_N PF18504.1 EFC50527.1 - 5 7.5 9.0 3.3 8.1 0.7 2.9 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF1664 PF07889.12 EFC50528.1 - 4.6 7.3 13.5 4.3 7.4 4.7 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) RINGv PF12906.7 EFC50529.1 - 7.5e-12 45.2 8.4 1.7e-11 44.1 8.4 1.6 1 0 0 1 1 1 1 RING-variant domain HemY_N PF07219.13 EFC50529.1 - 1.3 9.2 3.9 7.8 6.7 0.1 2.9 3 0 0 3 3 3 0 HemY protein N-terminus Pam17 PF08566.10 EFC50529.1 - 3.6 7.4 4.4 1.6 8.5 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial import protein Pam17 REJ PF02010.15 EFC50530.1 - 3.4e-34 118.4 12.5 3.4e-34 118.4 12.5 3.0 2 2 0 2 2 2 1 REJ domain EGF_2 PF07974.13 EFC50530.1 - 0.00021 21.6 26.0 0.00052 20.3 8.0 38.9 34 7 4 40 40 40 13 EGF-like domain EGF PF00008.27 EFC50530.1 - 0.00038 20.7 2.1 0.00038 20.7 2.1 35.6 35 3 1 36 36 36 6 EGF-like domain TMEM154 PF15102.6 EFC50530.1 - 0.0023 17.8 1.4 0.011 15.6 1.4 2.2 1 0 0 1 1 1 1 TMEM154 protein family Stevor PF17410.2 EFC50530.1 - 0.14 11.7 3.6 0.18 11.4 0.0 2.6 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame DUF4116 PF13475.6 EFC50531.1 - 1.4e-05 24.7 0.2 1.8 8.4 0.0 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF4116) DUF4116 PF13475.6 EFC50532.1 - 2.6e-26 91.1 6.3 7.6e-12 44.8 0.1 3.9 2 1 1 4 4 4 3 Domain of unknown function (DUF4116) TFIID-18kDa PF02269.16 EFC50533.1 - 2e-26 91.8 0.2 2.2e-26 91.7 0.2 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit TAF PF02969.17 EFC50533.1 - 0.014 15.6 0.0 0.02 15.0 0.0 1.3 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 EFC50533.1 - 0.1 12.9 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Peptidase_C48 PF02902.19 EFC50534.1 - 1.6e-18 67.4 0.1 6.1e-18 65.5 0.1 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C5 PF00770.18 EFC50534.1 - 0.0011 18.6 0.0 0.0021 17.8 0.0 1.5 1 0 0 1 1 1 1 Adenovirus endoprotease Glutaredoxin PF00462.24 EFC50535.1 - 1.3e-15 57.4 0.0 2.3e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Sec10 PF07393.11 EFC50536.1 - 5.6e-91 306.1 41.3 1.1e-71 242.3 20.3 4.9 3 1 2 5 5 5 2 Exocyst complex component Sec10 TetR_C_8 PF14278.6 EFC50536.1 - 0.0015 18.6 1.9 2.6 8.2 0.1 4.0 2 0 0 2 2 2 2 Transcriptional regulator C-terminal region DUF948 PF06103.11 EFC50536.1 - 0.08 13.2 10.2 0.099 12.9 2.6 3.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF2935 PF11155.8 EFC50536.1 - 0.66 10.3 0.0 0.66 10.3 0.0 5.5 2 2 1 3 3 3 0 Domain of unknown function (DUF2935) RFC1 PF08519.12 EFC50536.1 - 1.6 8.9 7.8 0.42 10.8 0.5 3.6 3 0 0 3 3 3 0 Replication factor RFC1 C terminal domain Spectrin PF00435.21 EFC50536.1 - 3.4 8.2 16.7 0.044 14.3 2.7 3.8 3 1 0 3 3 3 0 Spectrin repeat ABC_tran PF00005.27 EFC50537.1 - 3.5e-26 92.3 0.1 6.3e-26 91.5 0.0 1.5 2 0 0 2 2 1 1 ABC transporter AAA_25 PF13481.6 EFC50537.1 - 9.8e-06 25.3 0.0 0.00025 20.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 EFC50537.1 - 1.1e-05 25.5 0.6 0.012 15.5 0.4 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 EFC50537.1 - 0.001 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 EFC50537.1 - 0.0019 18.6 0.6 0.028 14.8 0.5 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SipA_VBS PF17985.1 EFC50537.1 - 0.0019 18.0 1.4 0.24 11.4 0.1 3.4 3 0 0 3 3 3 1 SipA vinculin binding site RsgA_GTPase PF03193.16 EFC50537.1 - 0.0027 17.6 0.1 0.0049 16.8 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 EFC50537.1 - 0.0049 17.4 0.5 0.0082 16.7 0.4 1.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC50537.1 - 0.0062 17.1 0.0 0.011 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 EFC50537.1 - 0.0064 16.0 0.1 0.086 12.3 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 EFC50537.1 - 0.0088 16.3 0.4 0.032 14.5 0.4 1.9 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 EFC50537.1 - 0.012 15.3 0.1 2.8 7.5 0.0 2.9 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 EFC50537.1 - 0.012 15.8 0.2 0.023 14.9 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 EFC50537.1 - 0.02 15.2 0.0 0.037 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 EFC50537.1 - 0.024 14.4 0.2 0.056 13.2 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 EFC50537.1 - 0.029 14.3 0.1 0.055 13.4 0.1 1.5 1 0 0 1 1 1 0 NACHT domain ABC_ATPase PF09818.9 EFC50537.1 - 0.043 12.6 0.1 0.088 11.6 0.1 1.4 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_14 PF13173.6 EFC50537.1 - 0.087 12.9 0.1 0.18 11.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 EFC50537.1 - 0.089 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 EFC50537.1 - 0.1 13.0 0.0 0.28 11.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase cobW PF02492.19 EFC50537.1 - 0.12 11.9 0.4 1.9 8.1 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 EFC50537.1 - 0.15 11.7 0.1 0.24 11.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 EFC50537.1 - 0.16 11.7 0.6 0.37 10.5 0.1 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ELP6 PF09807.9 EFC50538.1 - 1.4e-36 126.2 2.9 2.3e-36 125.5 2.9 1.3 1 1 0 1 1 1 1 Elongation complex protein 6 Elong_Iki1 PF10483.9 EFC50538.1 - 0.00026 20.6 0.3 0.00052 19.6 0.3 1.6 1 1 0 1 1 1 1 Elongator subunit Iki1 ATPase PF06745.13 EFC50538.1 - 0.00029 20.2 0.1 0.0012 18.2 0.1 1.8 1 1 0 1 1 1 1 KaiC PAXNEB PF05625.11 EFC50538.1 - 0.00033 19.9 0.4 0.00037 19.8 0.4 1.2 1 0 0 1 1 1 1 PAXNEB protein ATPase_2 PF01637.18 EFC50538.1 - 0.0075 16.2 0.2 0.011 15.7 0.2 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RadC PF04002.15 EFC50538.1 - 0.039 13.9 0.1 0.064 13.2 0.1 1.3 1 0 0 1 1 1 0 RadC-like JAB domain RhoGEF PF00621.20 EFC50539.1 - 1e-38 133.4 11.7 3e-29 102.6 1.0 5.6 5 2 0 6 6 6 2 RhoGEF domain TolA_bind_tri PF16331.5 EFC50539.1 - 0.011 15.8 1.4 0.011 15.8 1.4 5.9 5 2 0 5 5 5 0 TolA binding protein trimerisation TraF_2 PF13729.6 EFC50539.1 - 0.21 11.0 8.0 3.6 6.9 1.1 3.1 2 0 0 2 2 2 0 F plasmid transfer operon, TraF, protein MbeD_MobD PF04899.12 EFC50539.1 - 1.8 8.8 9.5 0.11 12.6 1.3 3.4 3 1 0 3 3 3 0 MbeD/MobD like Scaffolding_pro PF11418.8 EFC50539.1 - 3.8 8.1 17.6 0.61 10.7 4.3 4.2 3 1 0 3 3 3 0 Phi29 scaffolding protein Mito_carr PF00153.27 EFC50540.1 - 4e-78 257.4 3.7 3.2e-28 97.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 EFC50540.1 - 0.095 11.8 1.0 0.48 9.5 1.0 2.5 1 1 0 1 1 1 0 Gammaproteobacterial serine protease COP-gamma_platf PF08752.10 EFC50541.1 - 0.023 14.8 0.1 0.037 14.1 0.1 1.3 1 0 0 1 1 1 0 Coatomer gamma subunit appendage platform subdomain MFS_1 PF07690.16 EFC50542.1 - 1.5e-22 80.1 24.9 1.2e-10 40.9 16.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 EFC50542.1 - 4.1e-14 52.0 26.9 5.6e-09 35.1 6.9 3.1 2 1 1 3 3 3 2 MFS/sugar transport protein PUCC PF03209.15 EFC50542.1 - 2.5e-06 26.8 2.1 0.00016 20.8 0.1 2.2 2 0 0 2 2 2 2 PUCC protein DUF2583 PF10762.9 EFC50542.1 - 5.3 7.5 7.7 38 4.8 2.1 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF2583) Fibrinogen_C PF00147.18 EFC50543.1 - 1.4e-05 25.0 0.0 3.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain EGF_2 PF07974.13 EFC50543.1 - 0.065 13.6 16.0 0.91 10.0 1.3 3.3 2 1 0 2 2 2 0 EGF-like domain zf-C2HCIx2C PF10782.9 EFC50545.1 - 0.035 14.0 0.1 0.1 12.6 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger PPR_2 PF13041.6 EFC50546.1 - 5.1e-10 39.4 7.9 5e-07 29.8 0.8 3.1 2 1 1 3 3 3 2 PPR repeat family PPR PF01535.20 EFC50546.1 - 1.4e-06 28.1 1.8 0.18 12.1 0.1 4.4 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 EFC50546.1 - 3.9e-06 26.8 2.7 0.081 13.0 0.0 3.3 2 1 1 3 3 3 2 Pentatricopeptide repeat domain MNE1 PF13762.6 EFC50546.1 - 0.0035 17.4 1.4 0.072 13.1 0.3 2.5 1 1 1 2 2 2 1 Mitochondrial splicing apparatus component PPR_1 PF12854.7 EFC50546.1 - 0.0054 16.4 0.1 0.22 11.3 0.2 2.8 1 1 1 2 2 2 1 PPR repeat ANAPC3 PF12895.7 EFC50546.1 - 0.016 15.4 0.8 0.35 11.1 0.2 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF577 PF04510.12 EFC50546.1 - 0.083 12.8 2.6 0.07 13.0 1.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF577) DUF1657 PF07870.11 EFC50546.1 - 0.089 12.7 0.9 0.26 11.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1657) Ank_2 PF12796.7 EFC50547.1 - 4.4e-21 75.3 0.1 6e-10 39.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 EFC50547.1 - 8.5e-16 58.1 0.1 5.1e-07 30.1 0.0 4.0 2 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 EFC50547.1 - 3.3e-15 56.0 0.1 1.3e-05 25.3 0.0 3.5 2 2 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC50547.1 - 1.1e-13 50.0 0.0 0.00021 21.5 0.1 3.8 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 EFC50547.1 - 3.3e-12 46.3 0.1 0.00026 21.3 0.1 3.9 4 0 0 4 4 4 3 Ankyrin repeat DUF1843 PF08898.10 EFC50547.1 - 0.091 13.3 0.0 8.4 7.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) VHP PF02209.19 EFC50548.1 - 1.8e-12 47.1 0.3 1.8e-12 47.1 0.3 1.9 2 0 0 2 2 2 1 Villin headpiece domain DUF4375 PF14300.6 EFC50548.1 - 0.025 14.9 2.2 0.29 11.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) Nop PF01798.18 EFC50549.1 - 3.8e-68 229.4 0.0 7.8e-68 228.4 0.0 1.6 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 EFC50549.1 - 9.6e-21 74.9 1.3 2.7e-20 73.5 1.3 1.8 1 0 0 1 1 1 1 Prp31 C terminal domain SDP_N PF12278.8 EFC50549.1 - 0.59 10.3 5.0 0.69 10.1 0.2 2.9 3 0 0 3 3 3 0 Sex determination protein N terminal Cyclin_N PF00134.23 EFC50550.1 - 7.5e-09 35.4 2.2 1.5e-07 31.2 2.0 3.1 2 1 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 EFC50550.1 - 1.2e-08 35.0 0.5 2.4e-07 30.8 0.2 2.2 1 1 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_C_2 PF16899.5 EFC50550.1 - 5.3e-06 26.8 0.7 1.8e-05 25.1 0.1 2.0 2 0 0 2 2 2 1 Cyclin C-terminal domain TFIIB PF00382.19 EFC50550.1 - 0.0072 16.3 0.1 4.8 7.3 0.0 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat LRR_9 PF14580.6 EFC50551.1 - 3.4e-59 199.2 6.0 4.8e-59 198.8 6.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 EFC50551.1 - 0.00067 20.0 19.0 0.0032 17.8 6.9 3.9 1 1 4 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 EFC50551.1 - 0.044 13.5 16.4 0.17 11.7 9.8 3.2 2 1 2 4 4 4 0 Leucine rich repeat APH PF01636.23 EFC50552.1 - 2.7e-11 43.8 0.0 4.7e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 EFC50552.1 - 1.3e-08 34.7 1.3 2.5e-08 33.8 0.1 1.9 2 0 0 2 2 2 1 Choline/ethanolamine kinase tRNA_lig_CPD PF08302.11 EFC50552.1 - 0.021 14.3 0.1 4.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Fungal tRNA ligase phosphodiesterase domain PBS_linker_poly PF00427.21 EFC50552.1 - 0.051 13.6 0.1 0.15 12.1 0.1 1.8 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide F-box-like PF12937.7 EFC50553.1 - 0.002 18.0 0.2 0.0059 16.5 0.2 1.8 1 0 0 1 1 1 1 F-box-like DUF2431 PF10354.9 EFC50553.1 - 0.036 14.3 1.0 3.3 8.0 0.2 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF2431) DUF2767 PF10965.8 EFC50553.1 - 0.044 13.8 0.0 0.23 11.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2767) ATP-synt_ab_C PF00306.27 EFC50553.1 - 9.3 6.6 8.4 1.3 9.3 0.1 3.3 4 0 0 4 4 4 0 ATP synthase alpha/beta chain, C terminal domain cwf18 PF08315.12 EFC50554.1 - 5.9e-11 43.2 15.4 6.6e-10 39.8 15.4 2.4 1 1 0 1 1 1 1 cwf18 pre-mRNA splicing factor MucBP_2 PF17965.1 EFC50554.1 - 0.072 13.7 0.9 0.072 13.7 0.9 1.9 2 0 0 2 2 2 0 Mucin binding domain PseudoU_synth_2 PF00849.22 EFC50555.1 - 2.7e-15 56.8 0.1 2.2e-14 53.8 0.1 2.3 1 1 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 EFC50555.1 - 2.6e-07 30.2 0.0 7e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 S4 domain PACT_coil_coil PF10495.9 EFC50556.1 - 1.4 9.5 7.6 0.61 10.7 0.4 3.5 3 0 0 3 3 3 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein SAM_1 PF00536.30 EFC50558.1 - 7.3e-10 39.1 0.5 1.4e-09 38.3 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PB1 PF00564.24 EFC50558.1 - 1.1e-08 34.9 0.5 2.4e-08 33.8 0.1 1.8 2 0 0 2 2 2 1 PB1 domain SAM_2 PF07647.17 EFC50558.1 - 4.9e-08 33.0 0.3 8.6e-08 32.2 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 EFC50558.1 - 0.00068 19.6 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain ANAPC1 PF12859.7 EFC50559.1 - 3.6e-06 27.6 0.0 0.0003 21.3 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 EFC50559.1 - 0.0031 17.9 14.4 0.056 13.9 0.5 5.5 5 0 0 5 5 5 2 Proteasome/cyclosome repeat Pkinase PF00069.25 EFC50560.1 - 5.2e-08 32.6 2.5 2.3e-07 30.5 2.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Myofilin PF15929.5 EFC50561.1 - 0.024 15.0 0.1 1.2 9.6 0.0 2.4 2 0 0 2 2 2 0 Myofilin F-box-like PF12937.7 EFC50561.1 - 0.029 14.3 0.0 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 F-box-like LIDHydrolase PF10230.9 EFC50562.1 - 1.9e-31 109.6 0.2 3e-31 108.9 0.2 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 EFC50562.1 - 0.021 14.1 0.0 0.05 12.9 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Cutinase PF01083.22 EFC50562.1 - 0.024 14.6 0.0 0.07 13.1 0.0 1.7 2 0 0 2 2 2 0 Cutinase Abhydrolase_1 PF00561.20 EFC50562.1 - 0.048 13.3 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold SNF2_N PF00176.23 EFC50563.1 - 3e-61 207.1 0.2 6e-61 206.1 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 EFC50563.1 - 2e-19 69.9 0.5 1.4e-18 67.2 0.1 2.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 EFC50563.1 - 1.3e-15 57.0 22.6 1.2e-10 41.2 6.4 3.3 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 EFC50563.1 - 8.8e-12 45.4 0.1 8.8e-12 45.4 0.1 4.1 6 0 0 6 6 6 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 EFC50563.1 - 0.032 14.4 0.0 0.21 11.7 0.0 2.5 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain ZapA PF05164.13 EFC50563.1 - 0.044 14.2 0.7 0.26 11.8 0.7 2.4 1 0 0 1 1 1 0 Cell division protein ZapA DUF2013 PF09431.10 EFC50563.1 - 0.14 12.4 1.3 0.28 11.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2013) LRR_6 PF13516.6 EFC50564.1 - 6.5e-13 47.6 26.2 0.067 13.3 0.5 8.3 7 0 0 7 7 7 6 Leucine Rich repeat LRR_1 PF00560.33 EFC50564.1 - 0.22 12.2 12.5 26 5.9 0.0 6.9 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_4 PF12799.7 EFC50564.1 - 0.84 10.2 21.8 0.37 11.3 4.6 4.7 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Methyltransf_23 PF13489.6 EFC50565.1 - 1.6e-21 76.8 0.0 2.6e-21 76.2 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 EFC50565.1 - 1.5e-19 70.4 0.0 2.9e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC50565.1 - 5.7e-17 61.9 0.0 7.5e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC50565.1 - 6.9e-17 61.9 0.0 1.3e-16 61.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 EFC50565.1 - 3.6e-16 59.7 0.4 8.1e-16 58.6 0.2 1.7 2 0 0 2 2 1 1 Methyltransferase domain CMAS PF02353.20 EFC50565.1 - 1.4e-13 50.8 0.0 1.7e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 EFC50565.1 - 5.5e-10 39.2 0.0 7.4e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 EFC50565.1 - 9.8e-09 35.0 0.0 1.7e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 EFC50565.1 - 1.3e-08 34.6 0.3 1.8e-08 34.1 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 EFC50565.1 - 1.7e-08 34.1 0.6 2.5e-08 33.6 0.6 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 EFC50565.1 - 4.6e-05 23.2 0.1 7.8e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Ubie_methyltran PF01209.18 EFC50565.1 - 6.1e-05 22.5 0.0 8.1e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 EFC50565.1 - 9.9e-05 21.4 0.0 0.00015 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 EFC50565.1 - 0.00069 19.3 0.0 0.0011 18.6 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DREV PF05219.12 EFC50565.1 - 0.001 18.2 0.1 0.0016 17.6 0.1 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_32 PF13679.6 EFC50565.1 - 0.0057 16.7 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 EFC50565.1 - 0.011 15.4 0.0 0.017 14.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 EFC50565.1 - 0.016 14.8 0.2 0.033 13.7 0.1 1.7 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase RrnaAD PF00398.20 EFC50565.1 - 0.024 13.7 0.0 0.046 12.8 0.0 1.6 1 1 1 2 2 2 0 Ribosomal RNA adenine dimethylase RWP-RK PF02042.15 EFC50567.1 - 1.6e-18 66.4 0.2 2.9e-18 65.6 0.2 1.4 1 0 0 1 1 1 1 RWP-RK domain Lambda_CIII PF02061.16 EFC50567.1 - 0.053 13.6 0.4 0.13 12.4 0.4 1.6 1 0 0 1 1 1 0 Lambda Phage CIII HTH_29 PF13551.6 EFC50567.1 - 0.1 12.6 0.2 0.32 11.1 0.2 1.8 1 0 0 1 1 1 0 Winged helix-turn helix HTH_23 PF13384.6 EFC50567.1 - 0.11 12.3 0.1 0.45 10.4 0.0 1.9 1 1 1 2 2 2 0 Homeodomain-like domain STN1_2 PF09170.10 EFC50568.1 - 0.12 12.6 2.0 0.25 11.6 2.0 1.4 1 0 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 LAGLIDADG_1 PF00961.19 EFC50568.1 - 0.25 12.4 3.4 0.63 11.0 0.3 2.7 2 0 0 2 2 2 0 LAGLIDADG endonuclease Rpn3_C PF08375.11 EFC50569.1 - 0.22 12.0 3.0 0.33 11.4 0.0 2.8 3 0 0 3 3 3 0 Proteasome regulatory subunit C-terminal NAD_synthase PF02540.17 EFC50570.1 - 0.41 9.7 2.7 0.25 10.4 0.3 1.8 2 0 0 2 2 2 0 NAD synthase NdhL PF10716.9 EFC50570.1 - 0.61 10.1 6.6 0.47 10.4 4.1 2.0 2 0 0 2 2 2 0 NADH dehydrogenase transmembrane subunit DUF5401 PF17380.2 EFC50571.1 - 5 5.1 70.1 9 4.2 70.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5401) MACPF PF01823.19 EFC50572.1 - 1.2e-32 113.7 9.1 5.5e-16 59.3 0.9 2.4 2 0 0 2 2 2 2 MAC/Perforin domain Pam16 PF03656.13 EFC50573.1 - 1.8e-16 60.3 0.4 2e-16 60.1 0.4 1.1 1 0 0 1 1 1 1 Pam16 TssN PF17555.2 EFC50573.1 - 0.033 13.6 1.0 0.045 13.1 1.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN HJURP_C PF12347.8 EFC50573.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat DisA_N PF02457.16 EFC50573.1 - 0.067 12.8 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding Mitofilin PF09731.9 EFC50575.1 - 5.2e-38 131.3 45.9 4.4e-35 121.7 2.6 2.1 2 0 0 2 2 2 2 Mitochondrial inner membrane protein Nup54 PF13874.6 EFC50575.1 - 6.4e-05 23.1 11.3 6.4e-05 23.1 11.3 3.6 2 1 1 3 3 3 1 Nucleoporin complex subunit 54 Baculo_PEP_C PF04513.12 EFC50575.1 - 0.0093 16.0 9.1 0.0093 16.0 9.1 4.3 4 0 0 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus Aldedh PF00171.22 EFC50575.1 - 0.024 13.1 1.9 0.043 12.3 1.9 1.3 1 0 0 1 1 1 0 Aldehyde dehydrogenase family DUF5336 PF17270.2 EFC50575.1 - 0.076 12.6 1.6 0.15 11.6 1.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5336) Fez1 PF06818.15 EFC50575.1 - 0.081 13.4 37.6 0.066 13.7 14.2 2.7 2 0 0 2 2 2 0 Fez1 FAM184 PF15665.5 EFC50575.1 - 0.67 9.7 53.0 1.7 8.4 18.8 3.4 2 1 1 3 3 3 0 Family with sequence similarity 184, A and B ApoO PF09769.9 EFC50575.1 - 0.85 9.6 13.1 0.37 10.8 1.6 3.5 3 1 0 3 3 3 0 Apolipoprotein O APG6_N PF17675.1 EFC50575.1 - 3.5 8.2 52.1 0.95 10.0 14.9 3.7 2 1 0 2 2 2 0 Apg6 coiled-coil region DinB PF05163.12 EFC50575.1 - 4.1 7.3 15.5 0.22 11.4 3.8 2.5 2 0 0 2 2 2 0 DinB family Methyltransf_8 PF05148.15 EFC50576.1 - 6.9e-64 215.7 0.0 7.5e-64 215.6 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 EFC50576.1 - 4e-06 27.4 0.0 1e-05 26.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC50576.1 - 0.00024 21.7 0.0 0.013 16.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 EFC50576.1 - 0.087 12.6 0.1 4.4 7.1 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain Hydrolase_4 PF12146.8 EFC50577.1 - 7.1e-12 45.1 0.0 1.2e-09 37.8 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC50577.1 - 4.3e-06 26.6 0.1 7e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 EFC50577.1 - 0.00014 22.6 0.0 0.00016 22.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 EFC50577.1 - 0.00024 20.8 0.1 0.0011 18.6 0.2 2.0 3 0 0 3 3 3 1 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 EFC50577.1 - 0.00056 18.7 0.0 0.45 9.1 0.0 2.1 1 1 1 2 2 2 2 Acetyl xylan esterase (AXE1) FSH1 PF03959.13 EFC50577.1 - 0.0057 16.3 0.1 0.011 15.5 0.1 1.5 1 1 0 1 1 1 1 Serine hydrolase (FSH1) PAF-AH_p_II PF03403.13 EFC50577.1 - 0.018 13.6 0.1 4.2 5.8 0.0 2.3 2 1 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Peptidase_S9 PF00326.21 EFC50577.1 - 0.071 12.6 0.0 0.57 9.6 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family CTD_bind PF04818.13 EFC50578.1 - 2.5e-06 28.2 0.3 1.2e-05 26.0 0.1 2.4 2 0 0 2 2 1 1 RNA polymerase II-binding domain. VHS PF00790.19 EFC50578.1 - 0.00019 21.3 0.1 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 1 VHS domain zf-C2H2_11 PF16622.5 EFC50578.1 - 0.00087 19.0 0.3 0.0019 17.9 0.3 1.5 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 EFC50578.1 - 0.004 17.1 4.4 0.044 13.8 0.7 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger DUF995 PF06191.12 EFC50578.1 - 0.017 14.8 0.1 1.4 8.6 0.0 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF995) CFIA_Pcf11 PF11526.8 EFC50578.1 - 0.031 14.7 0.3 0.031 14.7 0.3 3.1 3 0 0 3 3 2 0 Subunit of cleavage factor IA Pcf11 zf-C2H2 PF00096.26 EFC50578.1 - 0.05 14.1 2.7 0.25 11.8 0.3 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 EFC50578.1 - 0.083 13.2 2.4 0.21 11.9 0.8 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn-ribbon_8 PF09723.10 EFC50578.1 - 0.1 12.7 0.8 2.5 8.3 0.0 2.9 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_9 PF16293.5 EFC50578.1 - 0.11 12.4 0.1 7.3 6.5 0.0 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-HYPF PF07503.12 EFC50578.1 - 0.11 12.3 1.1 0.73 9.7 0.0 2.3 2 0 0 2 2 2 0 HypF finger zf-C2H2_4 PF13894.6 EFC50578.1 - 0.11 13.3 3.5 0.24 12.3 0.3 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Axin_b-cat_bind PF08833.10 EFC50578.1 - 0.2 11.8 1.6 0.41 10.8 1.6 1.5 1 0 0 1 1 1 0 Axin beta-catenin binding domain RTC PF01137.21 EFC50579.1 - 1.1e-43 149.0 0.0 1.3e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 EFC50579.1 - 2.4e-32 111.5 0.0 3.9e-32 110.8 0.0 1.3 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain EF-hand_13 PF17958.1 EFC50580.1 - 8.8e-27 92.7 0.3 1.3e-25 89.1 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 EFC50580.1 - 3.1e-16 59.6 0.5 3.1e-16 59.6 0.5 3.8 4 2 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.32 EFC50580.1 - 2.4e-08 33.0 1.6 0.0034 16.8 0.0 4.2 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 EFC50580.1 - 4.6e-08 32.2 2.4 0.00068 19.0 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 EFC50580.1 - 5.2e-07 29.4 6.4 0.037 13.9 0.3 4.1 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 EFC50580.1 - 2.6e-06 26.9 6.7 0.063 13.2 0.0 5.3 5 0 0 5 5 5 2 EF-hand domain SPARC_Ca_bdg PF10591.9 EFC50580.1 - 0.081 13.3 0.6 4.1 7.8 0.1 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Paramyxo_C PF01692.18 EFC50580.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C ELO PF01151.18 EFC50581.1 - 2.4e-49 168.2 16.4 2.9e-49 167.9 16.4 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Tctex-1 PF03645.13 EFC50583.1 - 1e-27 96.4 3.0 1.2e-27 96.2 3.0 1.0 1 0 0 1 1 1 1 Tctex-1 family KORA PF16509.5 EFC50583.1 - 0.063 13.6 0.1 0.15 12.4 0.1 1.6 1 1 1 2 2 2 0 TrfB plasmid transcriptional repressor Syntaxin_2 PF14523.6 EFC50584.1 - 2.2e-08 34.4 18.3 1.5e-07 31.7 10.7 3.5 2 1 1 3 3 3 1 Syntaxin-like protein Syntaxin PF00804.25 EFC50584.1 - 0.0012 18.6 18.2 0.0015 18.3 1.0 3.1 1 1 1 2 2 2 1 Syntaxin SlyX PF04102.12 EFC50584.1 - 0.0024 18.4 8.3 0.1 13.3 0.6 4.0 3 1 1 4 4 4 2 SlyX FH2 PF02181.23 EFC50584.1 - 0.017 14.3 0.1 0.017 14.3 0.1 3.1 3 0 0 3 3 3 0 Formin Homology 2 Domain ER PF01133.17 EFC50584.1 - 0.088 12.8 0.5 0.36 10.9 0.1 2.1 2 0 0 2 2 2 0 Enhancer of rudimentary FlaC_arch PF05377.11 EFC50584.1 - 0.11 12.9 0.2 0.11 12.9 0.2 4.0 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) CLZ PF16526.5 EFC50584.1 - 0.21 12.0 8.6 1.6 9.1 0.0 3.8 4 1 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pro_3_hydrox_C PF05373.11 EFC50585.1 - 0.047 13.8 0.0 0.068 13.3 0.0 1.4 1 1 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal PhoPQ_related PF10142.9 EFC50586.1 - 1.8e-95 319.7 0.4 2.1e-95 319.5 0.4 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Peptidase_M20 PF01546.28 EFC50587.1 - 1e-13 51.4 0.0 9.4e-13 48.3 0.0 2.2 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 EFC50587.1 - 1.4e-08 34.6 0.0 4.5e-08 33.0 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain RNase_H2-Ydr279 PF09468.10 EFC50588.1 - 4.7e-08 33.4 2.6 1.1e-07 32.2 2.6 1.9 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ribosomal_L3 PF00297.22 EFC50589.1 - 9e-18 64.4 1.2 8.9e-15 54.5 0.9 2.4 1 1 1 2 2 2 2 Ribosomal protein L3 Acetyltransf_1 PF00583.25 EFC50590.1 - 3.9e-15 56.1 0.1 5.1e-15 55.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 EFC50590.1 - 6.4e-10 39.1 0.1 8.9e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 EFC50590.1 - 2.6e-09 37.4 0.6 3.3e-09 37.1 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 EFC50590.1 - 1.3e-08 34.7 0.0 2e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 EFC50590.1 - 2.5e-05 24.5 0.1 3e-05 24.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 EFC50590.1 - 0.0063 16.6 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain CMAS PF02353.20 EFC50590.1 - 0.095 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ras PF00071.22 EFC50591.1 - 5e-59 198.5 0.1 6.3e-59 198.2 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50591.1 - 3e-21 75.9 0.0 5.5e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50591.1 - 1.2e-10 41.2 0.0 1.4e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC50591.1 - 4.3e-06 26.4 0.4 1.1e-05 25.0 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC50591.1 - 9.7e-05 22.3 0.0 0.14 12.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 EFC50591.1 - 0.0014 17.9 0.4 0.035 13.3 0.0 2.2 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 EFC50591.1 - 0.0018 18.3 0.0 0.0048 17.0 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase SRP72 PF08492.12 EFC50591.1 - 0.006 17.0 3.0 0.012 16.0 3.0 1.4 1 0 0 1 1 1 1 SRP72 RNA-binding domain SIL1 PF16782.5 EFC50591.1 - 0.042 13.1 0.1 0.058 12.6 0.1 1.3 1 1 0 1 1 1 0 Nucleotide exchange factor SIL1 DUF4604 PF15377.6 EFC50591.1 - 0.53 10.7 13.7 1.5 9.2 13.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) E1-E2_ATPase PF00122.20 EFC50592.1 - 7.4e-44 149.4 1.7 7.4e-44 149.4 1.7 2.9 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 EFC50592.1 - 2.5e-42 144.7 4.9 2.5e-42 144.7 4.9 2.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 EFC50592.1 - 3.7e-21 76.4 0.1 2.7e-19 70.3 0.1 3.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 EFC50592.1 - 5.8e-18 64.8 0.0 1.2e-17 63.8 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 EFC50592.1 - 9e-17 60.5 0.0 1.7e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 EFC50592.1 - 5.9e-06 26.2 1.6 0.023 14.4 1.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 EFC50592.1 - 0.0082 16.6 0.0 0.055 13.9 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4133 PF13571.6 EFC50592.1 - 2.3 8.6 5.8 0.3 11.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) DUF202 PF02656.15 EFC50593.1 - 1.9e-13 50.7 1.8 3.6e-13 49.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Hamartin PF04388.12 EFC50593.1 - 0.13 10.9 11.8 0.15 10.7 11.8 1.0 1 0 0 1 1 1 0 Hamartin protein DUF2368 PF10166.9 EFC50593.1 - 0.32 10.6 0.1 0.32 10.6 0.1 2.3 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) TIP_N PF12457.8 EFC50593.1 - 0.34 11.3 6.3 0.53 10.7 6.3 1.3 1 0 0 1 1 1 0 Tuftelin interacting protein N terminal Clr2 PF10383.9 EFC50593.1 - 0.81 10.5 3.4 1.3 9.8 3.4 1.2 1 0 0 1 1 1 0 Transcription-silencing protein Clr2 ArlS_N PF18719.1 EFC50593.1 - 1.6 8.9 11.9 2.6 8.3 11.9 1.4 1 0 0 1 1 1 0 ArlS sensor domain DNA_methylase PF00145.17 EFC50593.1 - 2 7.7 7.6 2.6 7.3 7.6 1.1 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase MscS_TM PF12794.7 EFC50593.1 - 2.4 6.9 8.6 0.031 13.2 0.8 1.8 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Pannexin_like PF12534.8 EFC50593.1 - 7.7 5.5 9.6 12 4.8 9.6 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 SMYLE_N PF18615.1 EFC50593.1 - 9.5 5.7 9.5 12 5.4 9.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FAM76 PF16046.5 EFC50595.1 - 0.31 10.4 2.5 0.42 9.9 2.5 1.1 1 0 0 1 1 1 0 FAM76 protein Ephrin_rec_like PF07699.13 EFC50595.1 - 9.3 6.1 10.9 4.8e+02 0.6 10.9 2.8 1 1 0 1 1 1 0 Putative ephrin-receptor like CHZ PF09649.10 EFC50596.1 - 3.2e-05 23.3 1.9 4.3e-05 22.9 0.4 2.1 2 0 0 2 2 2 1 Histone chaperone domain CHZ LAP1C PF05609.12 EFC50596.1 - 0.024 13.8 12.8 0.029 13.5 12.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DDHD PF02862.17 EFC50596.1 - 0.083 13.0 4.8 0.12 12.6 4.8 1.4 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 EFC50596.1 - 0.26 10.0 15.7 0.34 9.6 15.7 1.1 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 EFC50596.1 - 0.48 9.8 31.7 0.66 9.3 31.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hid1 PF12722.7 EFC50596.1 - 1.4 7.0 14.8 1.8 6.6 14.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2052 PF09747.9 EFC50596.1 - 1.4 9.0 20.3 2.3 8.3 20.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Zip PF02535.22 EFC50596.1 - 2.2 7.4 10.6 2.9 7.0 10.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 EFC50596.1 - 2.2 7.2 14.7 3 6.7 14.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 EFC50596.1 - 3.3 6.3 5.4 3.6 6.2 5.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Membralin PF09746.9 EFC50596.1 - 3.5 6.6 8.7 4.5 6.2 8.7 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF4569 PF15133.6 EFC50596.1 - 5.4 6.7 16.0 8.1 6.1 16.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) MCM_bind PF09739.9 EFC50596.1 - 7 5.0 14.6 11 4.4 14.6 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SAPS PF04499.15 EFC50596.1 - 7.7 5.2 14.3 11 4.7 14.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RICTOR_M PF14666.6 EFC50597.1 - 2.8e-25 88.1 1.3 3.9e-23 81.2 0.4 4.5 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 EFC50597.1 - 9.5e-09 35.6 0.4 9.5e-09 35.6 0.4 6.8 6 2 0 6 6 6 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 EFC50597.1 - 2.5e-08 34.0 0.9 2.7e-06 27.5 0.0 3.7 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 DUF2407_C PF13373.6 EFC50597.1 - 0.12 12.6 1.9 1 9.5 1.9 2.7 1 0 0 1 1 1 0 DUF2407 C-terminal domain SUIM_assoc PF16619.5 EFC50597.1 - 0.5 10.5 9.0 4.4 7.5 0.1 4.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DNA_pol3_delta2 PF13177.6 EFC50598.1 - 6.9e-15 55.2 0.3 4.3e-14 52.6 0.3 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EFC50598.1 - 4.8e-08 33.2 0.2 3.1e-07 30.5 0.0 2.3 2 1 0 2 2 2 1 Rad17 P-loop domain AAA PF00004.29 EFC50598.1 - 5.8e-08 33.2 0.1 2.9e-07 31.0 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 EFC50598.1 - 2e-06 27.7 0.1 4.2e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 EFC50598.1 - 0.00039 20.7 0.1 0.0015 18.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 EFC50598.1 - 0.0012 19.2 0.0 0.0044 17.3 0.0 2.0 2 0 0 2 2 1 1 AAA C-terminal domain AAA_16 PF13191.6 EFC50598.1 - 0.0016 18.9 0.2 0.024 15.0 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain Rep_fac_C PF08542.11 EFC50598.1 - 0.0019 18.6 0.2 0.02 15.3 0.0 2.7 2 0 0 2 2 2 1 Replication factor C C-terminal domain Mg_chelatase PF01078.21 EFC50598.1 - 0.0034 16.8 0.1 0.59 9.5 0.0 2.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Rpr2 PF04032.16 EFC50598.1 - 0.0038 17.5 3.6 0.23 11.8 3.5 2.5 1 1 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain ABC_tran PF00005.27 EFC50598.1 - 0.011 16.3 0.1 0.025 15.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter Sigma54_activ_2 PF14532.6 EFC50598.1 - 0.015 15.4 0.1 0.49 10.5 0.1 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 EFC50598.1 - 0.023 14.4 0.0 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TniB PF05621.11 EFC50598.1 - 0.028 13.8 0.0 0.12 11.8 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein Bac_DnaA PF00308.18 EFC50598.1 - 0.032 14.1 0.8 8.5 6.1 0.0 2.9 2 1 1 3 3 3 0 Bacterial dnaA protein FtsK_SpoIIIE_N PF12538.8 EFC50598.1 - 0.039 14.2 0.2 0.11 12.7 0.1 1.9 2 0 0 2 2 2 0 DNA transporter DEAD PF00270.29 EFC50598.1 - 0.048 13.4 0.3 0.16 11.7 0.3 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase RsgA_GTPase PF03193.16 EFC50598.1 - 0.051 13.5 0.3 0.57 10.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_5 PF07728.14 EFC50598.1 - 0.065 13.2 0.0 0.39 10.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 EFC50598.1 - 0.068 12.5 0.1 0.18 11.1 0.0 1.6 1 1 0 1 1 1 0 FtsK/SpoIIIE family DUF815 PF05673.13 EFC50598.1 - 0.07 12.3 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) T2SSE PF00437.20 EFC50598.1 - 0.097 11.7 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_11 PF13086.6 EFC50598.1 - 0.099 12.4 0.5 0.68 9.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 EFC50598.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Helicase_C PF00271.31 EFC50599.1 - 1.4e-17 64.0 0.1 5.8e-16 58.8 0.0 3.1 3 1 0 4 4 4 1 Helicase conserved C-terminal domain DEAD PF00270.29 EFC50599.1 - 2.8e-16 59.8 0.0 6.5e-16 58.6 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 EFC50599.1 - 4.1e-07 30.1 0.0 2.7e-06 27.5 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit RecQ_Zn_bind PF16124.5 EFC50599.1 - 0.00047 20.8 1.7 0.0012 19.6 1.0 2.1 1 1 1 2 2 2 1 RecQ zinc-binding AAA_22 PF13401.6 EFC50599.1 - 0.0097 16.2 0.1 0.036 14.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain FeThRed_B PF02943.15 EFC50599.1 - 0.024 14.7 0.1 0.063 13.3 0.1 1.7 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain zinc_ribbon_5 PF13719.6 EFC50601.1 - 0.00034 20.3 0.5 0.00068 19.3 0.5 1.4 1 0 0 1 1 1 1 zinc-ribbon domain Pkinase PF00069.25 EFC50601.1 - 0.012 15.0 3.0 0.015 14.7 0.0 2.3 2 1 1 3 3 3 0 Protein kinase domain DZR PF12773.7 EFC50601.1 - 0.026 14.5 0.6 0.051 13.6 0.6 1.4 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 EFC50601.1 - 0.045 13.7 4.3 0.2 11.6 4.3 2.0 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 EFC50601.1 - 0.14 12.2 2.4 0.36 11.0 2.4 1.7 1 1 0 1 1 1 0 Zinc ribbon domain Elf1 PF05129.13 EFC50601.1 - 0.39 10.8 2.9 0.22 11.6 0.5 1.8 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like RNA_pol_Rpc4 PF05132.14 EFC50602.1 - 1.8e-26 93.4 0.3 1.8e-26 93.4 0.3 3.7 4 1 0 4 4 4 1 RNA polymerase III RPC4 DUF3770 PF12603.8 EFC50602.1 - 0.0091 15.5 0.2 0.013 15.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3770) DUF3446 PF11928.8 EFC50602.1 - 0.016 15.5 15.8 0.1 12.9 0.1 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain NAM-associated PF14303.6 EFC50602.1 - 0.033 14.9 1.2 18 6.0 0.0 2.6 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain Inp1 PF12634.7 EFC50602.1 - 0.6 10.1 3.1 4.6 7.3 0.7 2.5 2 1 0 2 2 2 0 Inheritance of peroxisomes protein 1 REJ PF02010.15 EFC50603.1 - 2.5e-38 132.0 3.6 2.5e-38 132.0 3.6 3.4 3 1 1 4 4 4 2 REJ domain EGF_2 PF07974.13 EFC50603.1 - 0.00015 22.0 58.0 0.0022 18.3 7.1 21.0 16 2 4 20 20 20 11 EGF-like domain EGF PF00008.27 EFC50603.1 - 0.00049 20.3 2.6 0.00049 20.3 2.6 18.8 18 1 1 19 19 19 5 EGF-like domain Big_3_3 PF13750.6 EFC50603.1 - 0.015 14.9 0.2 0.072 12.7 0.1 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) PKD PF00801.20 EFC50603.1 - 0.036 13.9 1.0 13 5.8 0.1 3.1 3 0 0 3 3 3 0 PKD domain DUF3704 PF12488.8 EFC50603.1 - 0.36 10.5 1.7 8.9 6.1 0.4 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3704) Actin PF00022.19 EFC50604.1 - 4.3e-131 437.3 0.0 2e-130 435.1 0.0 1.7 1 1 0 1 1 1 1 Actin TPR_1 PF00515.28 EFC50605.1 - 6.1e-14 51.1 4.3 0.00037 20.2 0.5 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50605.1 - 2.3e-11 42.9 0.7 0.00051 20.0 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50605.1 - 7.1e-06 25.8 3.9 0.049 13.9 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 EFC50605.1 - 0.001 19.3 0.2 0.061 13.6 0.1 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50605.1 - 0.003 17.2 2.0 3.1 7.6 0.0 3.5 3 1 1 4 4 4 2 TPR repeat TPR_7 PF13176.6 EFC50605.1 - 0.0033 17.3 0.3 0.42 10.8 0.0 3.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50605.1 - 0.01 16.2 2.8 4.3 7.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50605.1 - 0.011 16.0 0.5 0.021 15.1 0.5 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 NYD-SP12_N PF15015.6 EFC50605.1 - 0.027 12.8 0.1 0.03 12.7 0.1 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal TPR_14 PF13428.6 EFC50605.1 - 0.042 14.7 0.0 0.57 11.1 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50605.1 - 0.048 14.2 0.1 0.21 12.1 0.1 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50605.1 - 0.056 14.1 0.1 9.8 7.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 EFC50605.1 - 0.13 12.3 2.2 1.2 9.2 0.2 2.8 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Ank_2 PF12796.7 EFC50606.1 - 6.8e-16 58.6 0.0 8.3e-09 35.9 0.0 2.7 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) TPR_2 PF07719.17 EFC50606.1 - 9.3e-10 37.9 6.0 0.00016 21.5 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50606.1 - 3.2e-09 36.2 9.2 6e-06 25.9 0.2 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat Ank_3 PF13606.6 EFC50606.1 - 3.2e-08 33.2 0.1 0.017 15.6 0.1 4.6 5 0 0 5 5 3 2 Ankyrin repeat TPR_12 PF13424.6 EFC50606.1 - 5.4e-06 26.6 0.2 0.022 15.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50606.1 - 1.1e-05 25.0 3.8 8.3e-05 22.2 0.2 3.2 3 1 1 4 4 4 1 TPR repeat Ank_4 PF13637.6 EFC50606.1 - 1.8e-05 25.2 0.0 0.0003 21.3 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 EFC50606.1 - 5e-05 23.6 0.0 0.36 11.4 0.1 3.9 3 0 0 3 3 3 1 Ankyrin repeat ST7 PF04184.12 EFC50606.1 - 0.00025 19.7 0.1 0.00036 19.1 0.1 1.2 1 0 0 1 1 1 1 ST7 protein TPR_16 PF13432.6 EFC50606.1 - 0.00039 21.0 0.3 0.1 13.3 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50606.1 - 0.00051 19.9 1.1 1.3 9.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 EFC50606.1 - 0.0027 18.2 0.3 2.9 8.4 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat Ank_5 PF13857.6 EFC50606.1 - 0.0058 16.9 0.2 0.3 11.5 0.0 3.3 3 1 1 4 4 3 1 Ankyrin repeats (many copies) TPR_8 PF13181.6 EFC50606.1 - 0.0069 16.5 0.1 0.0069 16.5 0.1 4.3 5 0 0 5 5 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50606.1 - 0.019 15.2 8.7 0.56 10.5 0.1 4.2 4 1 0 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 EFC50606.1 - 0.03 14.2 0.5 1.3 9.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 EFC50606.1 - 0.13 12.3 0.6 0.63 10.1 0.4 2.3 2 1 0 2 2 2 0 Domain of Unknown Function (DUF3856) SRP_TPR_like PF17004.5 EFC50606.1 - 0.14 12.2 7.4 10 6.2 2.4 3.7 2 1 1 3 3 3 0 Putative TPR-like repeat TPR_6 PF13174.6 EFC50606.1 - 0.15 12.7 0.8 14 6.5 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 EFC50606.1 - 0.25 11.7 3.3 25 5.4 0.1 3.7 3 0 0 3 3 3 0 PPR repeat Granin PF01271.17 EFC50606.1 - 0.29 10.0 3.4 0.41 9.5 3.4 1.1 1 0 0 1 1 1 0 Granin (chromogranin or secretogranin) MIT PF04212.18 EFC50606.1 - 1 9.5 5.8 3.7 7.7 0.1 3.2 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain Ras PF00071.22 EFC50607.1 - 7.5e-45 152.4 0.0 9.8e-45 152.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50607.1 - 3.7e-17 62.7 0.0 6.8e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50607.1 - 2.1e-05 24.0 0.0 5.2e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Ceramidase PF05875.12 EFC50609.1 - 1.3e-37 129.7 22.4 1.7e-37 129.3 22.4 1.0 1 0 0 1 1 1 1 Ceramidase BTB PF00651.31 EFC50610.1 - 4.2e-07 30.2 0.9 1e-05 25.7 0.4 2.8 2 1 0 2 2 2 1 BTB/POZ domain GTP1_OBG PF01018.22 EFC50611.1 - 1.1e-05 25.1 0.4 2.5e-05 23.9 0.4 1.6 1 0 0 1 1 1 1 GTP1/OBG tRNA-synt_1c PF00749.21 EFC50613.1 - 5.3e-101 337.6 0.1 6.6e-101 337.3 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Ras PF00071.22 EFC50614.1 - 1.2e-11 44.5 0.1 3.4e-11 43.0 0.1 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 EFC50614.1 - 2.4e-06 27.8 0.4 5.8e-06 26.5 0.4 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PFU PF09070.11 EFC50614.1 - 5e-06 26.7 0.3 0.85 9.9 0.0 3.7 3 0 0 3 3 3 3 PFU (PLAA family ubiquitin binding) MCM PF00493.23 EFC50614.1 - 0.087 11.9 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Phage_Coat_A PF05357.13 EFC50615.1 - 0.14 12.0 1.5 0.14 12.0 0.3 1.6 1 1 1 2 2 2 0 Phage Coat Protein A ZYG-11_interact PF05884.12 EFC50616.1 - 0.065 12.6 2.5 0.089 12.2 2.4 1.2 1 1 0 1 1 1 0 Interactor of ZYG-11 Lipocalin_5 PF13924.6 EFC50617.1 - 0.12 12.1 0.0 0.65 9.8 0.0 1.9 1 1 1 2 2 2 0 Lipocalin-like domain Ogr_Delta PF04606.12 EFC50618.1 - 0.03 14.3 1.8 0.099 12.6 1.8 1.9 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger DnaJ_C PF01556.18 EFC50619.1 - 4.3e-41 140.5 1.7 5.5e-41 140.1 1.7 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFC50619.1 - 1.7e-28 98.5 2.0 3.2e-28 97.6 2.0 1.5 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 EFC50619.1 - 0.027 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein DUF4460 PF14687.6 EFC50619.1 - 0.13 12.3 0.7 0.38 10.8 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4460) PDCD2_C PF04194.13 EFC50620.1 - 3.8e-28 98.7 2.0 3.8e-28 98.7 2.0 2.8 1 1 1 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain MPP6 PF10175.9 EFC50620.1 - 0.012 16.1 2.7 0.012 16.1 2.7 2.7 2 1 0 2 2 2 0 M-phase phosphoprotein 6 SPT16 PF08644.11 EFC50620.1 - 0.014 15.6 0.2 0.014 15.6 0.2 2.0 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) NUDIX-like PF09296.11 EFC50620.1 - 0.044 14.4 0.1 0.098 13.3 0.1 1.6 1 0 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain Megourin PF17560.2 EFC50620.1 - 0.068 13.4 0.5 0.14 12.4 0.5 1.5 1 0 0 1 1 1 0 Aphid Megourins Kelch_6 PF13964.6 EFC50620.1 - 0.087 13.2 0.1 0.17 12.2 0.1 1.4 1 0 0 1 1 1 0 Kelch motif Poty_PP PF08440.10 EFC50620.1 - 0.12 11.4 2.7 0.35 9.9 2.7 1.7 1 0 0 1 1 1 0 Potyviridae polyprotein DUF3128 PF11326.8 EFC50620.1 - 7.2 7.0 8.8 37 4.8 8.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) HEAT PF02985.22 EFC50621.1 - 1.3e-05 25.0 5.3 0.36 11.2 0.1 5.8 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 EFC50621.1 - 0.00059 19.9 0.8 0.00059 19.9 0.8 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 EFC50621.1 - 0.00059 20.2 0.1 0.0077 16.6 0.0 2.8 2 0 0 2 2 2 1 HEAT repeats Pox_D3 PF04580.13 EFC50621.1 - 0.014 15.0 0.5 0.82 9.3 0.1 2.7 2 0 0 2 2 2 0 Chordopoxvirinae D3 protein HEAT_EZ PF13513.6 EFC50621.1 - 0.054 14.0 6.6 0.32 11.6 0.3 4.2 3 2 1 4 4 4 0 HEAT-like repeat DUF4329 PF14220.6 EFC50621.1 - 0.06 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4329) SPO22 PF08631.10 EFC50621.1 - 0.15 11.5 3.3 0.12 11.8 1.1 1.9 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like Lipoprotein_10 PF03202.13 EFC50621.1 - 0.22 12.0 1.8 0.52 10.8 0.3 2.3 2 0 0 2 2 2 0 Putative mycoplasma lipoprotein, C-terminal region 7tm_1 PF00001.21 EFC50622.1 - 0.00036 19.9 0.2 0.00045 19.6 0.2 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Orf78 PF06024.12 EFC50622.1 - 0.029 14.7 0.0 0.44 10.9 0.0 2.0 1 1 1 2 2 2 0 Orf78 (ac78) Pmp3 PF01679.17 EFC50622.1 - 0.059 13.6 8.8 0.78 10.0 3.6 2.4 2 1 0 2 2 2 0 Proteolipid membrane potential modulator DUF3225 PF11533.8 EFC50622.1 - 0.09 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3225) Ribosomal_S12 PF17487.2 EFC50622.1 - 0.55 11.0 6.5 7.9 7.3 0.3 2.3 2 0 0 2 2 2 0 Ribosomal protein S12 Mucin PF01456.17 EFC50623.1 - 7.7 6.5 17.1 8.3 6.4 17.1 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein BIR PF00653.21 EFC50624.1 - 8.4e-21 74.4 1.6 1.3e-20 73.8 1.6 1.3 1 0 0 1 1 1 1 Inhibitor of Apoptosis domain Tcp10_C PF07202.13 EFC50625.1 - 1.1e-30 106.9 0.5 1.1e-30 106.9 0.5 3.7 3 1 0 3 3 3 1 T-complex protein 10 C-terminus Lectin_N PF03954.14 EFC50625.1 - 0.0017 18.1 4.3 0.0017 18.1 4.3 3.4 3 1 1 4 4 4 1 Hepatic lectin, N-terminal domain DUF3912 PF13051.6 EFC50625.1 - 0.083 13.2 0.0 0.29 11.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3912) ApoO PF09769.9 EFC50625.1 - 1.2 9.1 4.9 2.1 8.3 3.0 2.5 1 1 1 2 2 2 0 Apolipoprotein O Sua5_yciO_yrdC PF01300.18 EFC50626.1 - 1.2e-42 145.4 0.0 4e-42 143.7 0.0 1.8 1 1 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 EFC50626.1 - 3e-11 44.0 0.0 6.4e-11 42.9 0.0 1.6 2 0 0 2 2 2 1 Putative GTP-binding controlling metal-binding TPR_12 PF13424.6 EFC50627.1 - 8.2e-19 67.7 2.6 0.00018 21.7 0.4 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50627.1 - 1.5e-10 40.4 3.2 0.17 12.1 0.2 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50627.1 - 1.5e-06 27.8 1.3 0.82 9.6 0.1 5.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50627.1 - 1.7e-06 27.7 9.6 0.19 12.0 0.2 5.1 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50627.1 - 7.3e-05 22.5 0.1 20 5.5 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50627.1 - 7.9e-05 23.0 0.4 10 7.0 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC50627.1 - 0.00049 19.6 1.4 0.0074 15.7 0.7 2.5 2 1 0 2 2 2 1 MalT-like TPR region TPR_19 PF14559.6 EFC50627.1 - 0.00057 20.4 6.6 0.14 12.7 2.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50627.1 - 0.00076 19.2 9.9 1.5 8.8 0.2 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50627.1 - 0.015 15.6 0.1 50 4.6 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50627.1 - 0.026 15.3 1.3 19 6.4 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50627.1 - 0.047 13.4 4.2 0.5 10.1 0.1 3.2 4 0 0 4 4 4 0 TPR repeat DUF4810 PF16068.5 EFC50627.1 - 0.07 13.7 3.2 0.2 12.2 0.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4810) DUF5130 PF17174.4 EFC50627.1 - 0.079 13.2 0.0 0.19 11.9 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5130) HemY_N PF07219.13 EFC50627.1 - 0.12 12.6 1.4 28 4.9 0.0 3.5 3 1 1 4 4 4 0 HemY protein N-terminus TPR_9 PF13371.6 EFC50627.1 - 0.18 11.9 0.6 7 6.9 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 EFC50627.1 - 0.57 10.4 6.0 1.7 9.0 2.9 3.1 2 2 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Thg1 PF04446.12 EFC50628.1 - 1.5e-25 89.6 3.5 3.7e-25 88.4 0.2 2.9 3 1 0 3 3 3 1 tRNAHis guanylyltransferase EGF_2 PF07974.13 EFC50629.1 - 3.9e-23 81.5 110.6 5.3e-06 26.7 9.0 7.4 7 0 0 7 7 7 7 EGF-like domain EGF PF00008.27 EFC50629.1 - 2.6e-07 30.8 79.5 0.1 13.0 2.5 8.3 7 0 0 7 7 7 7 EGF-like domain EGF_2 PF07974.13 EFC50630.1 - 3.8e-22 78.3 113.5 0.00018 21.8 10.7 7.4 7 0 0 7 7 7 7 EGF-like domain hEGF PF12661.7 EFC50630.1 - 0.062 14.0 9.1 0.062 14.0 9.1 9.5 10 0 0 10 10 10 0 Human growth factor-like EGF RCC1 PF00415.18 EFC50631.1 - 2.2e-08 34.6 0.1 2.3e-05 24.9 0.0 3.2 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 EFC50631.1 - 0.028 14.2 2.2 1.1 9.2 0.5 3.1 2 1 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat NIF PF03031.18 EFC50632.1 - 5.2e-35 120.5 0.1 7.4e-35 120.0 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FA_desaturase PF00487.24 EFC50633.1 - 6e-24 85.3 15.0 7.7e-23 81.6 15.0 2.1 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 EFC50633.1 - 4.6e-17 61.9 0.1 9.5e-17 60.9 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DNA_pol_B PF00136.21 EFC50634.1 - 2.8e-117 392.2 0.2 5.5e-116 388.0 0.2 2.3 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 EFC50634.1 - 1.6e-41 142.6 1.6 4.2e-41 141.2 1.6 1.7 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 EFC50634.1 - 5.2e-17 62.2 2.3 1.2e-16 61.1 2.3 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNTTIP1_dimer PF18192.1 EFC50634.1 - 0.057 13.8 1.4 8.7 6.8 0.0 2.8 2 0 0 2 2 2 0 DNTTIP1 dimerisation domain HypA PF01155.19 EFC50634.1 - 0.059 13.4 0.1 0.2 11.7 0.1 1.9 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA 4HB_MCP_1 PF12729.7 EFC50634.1 - 0.92 9.0 6.8 5.8 6.4 0.0 3.6 4 0 0 4 4 4 0 Four helix bundle sensory module for signal transduction E7 PF00527.18 EFC50634.1 - 7.5 6.8 6.5 0.51 10.6 0.4 2.3 2 0 0 2 2 2 0 E7 protein, Early protein DUF2039 PF10217.9 EFC50635.1 - 6.2e-29 100.2 17.7 9.5e-29 99.6 17.7 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zinc-ribbons_6 PF07191.12 EFC50635.1 - 0.019 14.9 13.5 0.031 14.2 13.5 1.3 1 0 0 1 1 1 0 zinc-ribbons HypA PF01155.19 EFC50635.1 - 7.3 6.7 12.4 0.28 11.2 0.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Fcf1 PF04900.12 EFC50636.1 - 8.5e-36 122.3 1.0 8.5e-36 122.3 1.0 1.6 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 EFC50636.1 - 9.8e-10 38.8 0.0 1.4e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 PIN like domain Utp12 PF04003.12 EFC50637.1 - 0.00015 22.0 2.5 0.00015 22.0 2.5 2.8 4 0 0 4 4 4 1 Dip2/Utp12 Family CK2S PF15011.6 EFC50637.1 - 0.23 11.4 3.0 0.44 10.4 0.2 2.6 3 0 0 3 3 3 0 Casein Kinase 2 substrate Cyt-b5 PF00173.28 EFC50638.1 - 5.1e-17 61.8 0.1 6.8e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Pkinase PF00069.25 EFC50639.1 - 1.8e-75 253.8 0.0 3.8e-75 252.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50639.1 - 6e-50 169.9 0.0 2.3e-49 168.0 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC50639.1 - 4.8e-07 29.4 0.0 0.0058 16.0 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 EFC50639.1 - 4.7e-05 22.4 0.0 0.00016 20.6 0.0 1.7 1 1 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 EFC50639.1 - 0.004 16.8 0.1 0.0089 15.7 0.1 1.6 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 EFC50639.1 - 0.017 14.5 0.4 0.038 13.3 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Arm PF00514.23 EFC50639.1 - 0.066 13.3 0.7 10 6.3 0.0 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Xpo1 PF08389.12 EFC50639.1 - 0.66 10.0 4.4 1.6 8.8 0.4 3.0 3 0 0 3 3 3 0 Exportin 1-like protein Radial_spoke PF04712.12 EFC50640.1 - 4.2e-83 280.0 1.7 9.2e-82 275.5 1.7 2.0 1 1 0 1 1 1 1 Radial spokehead-like protein Med18 PF09637.10 EFC50641.1 - 2.3e-05 24.4 0.1 2.9e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Med18 protein DUF2369 PF10179.9 EFC50641.1 - 0.016 15.6 0.1 0.028 14.8 0.1 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) PIP5K PF01504.18 EFC50642.1 - 1.3e-68 231.2 0.1 1.3e-68 231.2 0.1 3.1 4 0 0 4 4 4 1 Phosphatidylinositol-4-phosphate 5-Kinase EF-hand_6 PF13405.6 EFC50642.1 - 5.6e-11 41.5 5.1 0.012 15.5 0.1 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 EFC50642.1 - 1.5e-07 31.8 2.1 4.1e-06 27.2 0.4 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 EFC50642.1 - 2.3e-07 29.9 4.5 0.0044 16.5 0.1 3.8 4 0 0 4 4 4 2 EF hand EF-hand_5 PF13202.6 EFC50642.1 - 1.4e-05 24.4 3.9 0.033 13.7 0.2 3.5 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 EFC50642.1 - 0.0069 16.2 1.6 0.13 12.1 0.3 3.2 2 1 1 3 3 3 2 EF-hand domain pair MIT PF04212.18 EFC50642.1 - 0.2 11.7 0.3 0.68 10.0 0.1 2.0 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain DUF3285 PF11688.8 EFC50644.1 - 0.38 10.7 3.4 0.81 9.6 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3285) Ribosomal_S5 PF00333.20 EFC50645.1 - 3.7e-24 84.5 0.3 7.7e-24 83.5 0.3 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 EFC50645.1 - 1.2e-22 79.1 0.0 1.9e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Flavodoxin_3 PF12641.7 EFC50645.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain Mce4_CUP1 PF11887.8 EFC50647.1 - 0.016 14.7 1.3 0.075 12.5 0.0 2.3 1 1 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF1163 PF06651.11 EFC50647.1 - 0.029 14.5 0.7 0.029 14.5 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) ERK-JNK_inhib PF15002.6 EFC50649.1 - 0.0089 15.7 0.1 1.2 8.8 0.1 2.6 1 1 1 2 2 2 2 ERK and JNK pathways, inhibitor DUF4142 PF13628.6 EFC50649.1 - 0.2 11.9 0.1 0.87 9.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) RICTOR_M PF14666.6 EFC50649.1 - 0.44 10.3 4.1 0.32 10.8 0.3 2.6 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain WD40 PF00400.32 EFC50650.1 - 5.9e-36 121.9 27.9 6.9e-07 29.9 1.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50650.1 - 7e-14 51.9 0.4 0.09 13.1 0.0 6.1 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HrpB7 PF09486.10 EFC50650.1 - 0.041 14.3 1.4 0.07 13.5 1.4 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) WD40_like PF17005.5 EFC50650.1 - 0.049 13.0 0.1 0.16 11.2 0.0 1.9 1 1 0 1 1 1 0 WD40-like domain Amastin PF07344.11 EFC50650.1 - 0.11 12.3 0.4 0.28 11.0 0.2 1.7 1 1 1 2 2 2 0 Amastin surface glycoprotein Allexi_40kDa PF05549.11 EFC50650.1 - 1 8.8 8.8 1.8 8.0 1.1 2.2 2 0 0 2 2 2 0 Allexivirus 40kDa protein SPOB_a PF14689.6 EFC50650.1 - 2.3 8.0 9.2 2.4 7.9 1.5 2.5 1 1 1 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain Cortex-I_coil PF09304.10 EFC50650.1 - 2.5 8.3 17.0 0.038 14.2 5.3 3.1 1 1 3 4 4 4 0 Cortexillin I, coiled coil WASH_WAHD PF11945.8 EFC50651.1 - 6.8e-30 104.6 7.3 1.8e-28 99.9 7.3 2.2 1 1 0 1 1 1 1 WAHD domain of WASH complex WH2 PF02205.20 EFC50651.1 - 4.4e-08 32.7 1.0 8.2e-08 31.8 1.0 1.5 1 0 0 1 1 1 1 WH2 motif MitMem_reg PF13012.6 EFC50651.1 - 0.059 13.8 0.4 0.13 12.7 0.1 1.7 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function fn3_2 PF16893.5 EFC50652.1 - 0.05 13.8 0.0 0.26 11.5 0.0 2.3 1 0 0 1 1 1 0 Fibronectin type III domain TPH PF13868.6 EFC50654.1 - 1.9e-59 201.0 149.6 1.9e-59 201.0 149.6 2.0 1 1 1 2 2 2 1 Trichohyalin-plectin-homology domain IBR PF01485.21 EFC50655.1 - 2e-08 34.3 3.5 2e-08 34.3 3.5 7.2 5 2 1 6 6 6 1 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 EFC50655.1 - 3.8e-07 30.3 9.2 3.8e-07 30.3 9.2 6.6 6 3 0 6 6 6 2 Ring finger domain zf-RING_UBOX PF13445.6 EFC50655.1 - 4.7e-05 23.3 10.0 0.00083 19.3 4.0 6.5 8 0 0 8 8 8 2 RING-type zinc-finger zf-RING_5 PF14634.6 EFC50655.1 - 0.00012 21.9 18.7 0.00068 19.5 8.7 7.3 6 2 0 6 6 6 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 EFC50655.1 - 0.01 15.7 0.5 0.01 15.7 0.5 7.8 6 2 3 9 9 9 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 EFC50655.1 - 0.014 15.1 10.8 0.014 15.1 10.8 4.2 4 0 0 4 4 4 0 RING-like zinc finger zf-C3HC4 PF00097.25 EFC50655.1 - 0.022 14.6 0.2 0.022 14.6 0.2 7.8 7 2 1 8 8 8 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 EFC50655.1 - 0.09 12.7 0.6 0.09 12.7 0.6 7.4 3 1 2 5 5 5 0 Prokaryotic RING finger family 4 DnaJ PF00226.31 EFC50656.1 - 1.4e-15 57.1 0.6 1.4e-15 57.1 0.6 2.7 2 1 0 2 2 2 1 DnaJ domain Myb_DNA-binding PF00249.31 EFC50656.1 - 5.4e-11 42.5 2.5 1.9e-06 27.9 0.5 4.5 5 0 0 5 5 5 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC50656.1 - 5e-06 26.7 1.0 0.00071 19.8 0.4 4.3 5 0 0 5 5 5 2 Myb-like DNA-binding domain Peptidase_U4 PF03419.13 EFC50656.1 - 3.2 7.0 6.3 6.9 5.9 6.3 1.5 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Pkinase PF00069.25 EFC50657.1 - 9.3e-37 126.8 0.1 9.3e-37 126.8 0.1 2.1 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50657.1 - 3.3e-25 88.8 0.2 1.3e-24 86.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase EDR1 PF14381.6 EFC50657.1 - 1.3e-19 70.7 0.0 8.4e-19 68.1 0.0 2.1 1 1 0 2 2 2 1 Ethylene-responsive protein kinase Le-CTR1 Pkinase_fungal PF17667.1 EFC50657.1 - 0.00021 20.2 0.4 0.00039 19.3 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 EFC50657.1 - 0.002 17.5 0.1 0.0047 16.3 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Adenylsucc_synt PF00709.21 EFC50658.1 - 4.5e-168 559.5 0.0 5.2e-168 559.3 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase TMEM43 PF07787.12 EFC50659.1 - 2.9e-45 154.6 0.0 4.5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Transmembrane protein 43 CBM_X2 PF03442.14 EFC50659.1 - 0.056 13.6 0.1 0.2 11.8 0.0 1.9 2 0 0 2 2 2 0 Carbohydrate binding domain X2 TMEM206 PF15122.6 EFC50659.1 - 0.075 12.2 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 TMEM206 protein family Sec5 PF15469.6 EFC50660.1 - 1.5e-09 37.9 0.6 1.5e-09 37.9 0.6 6.2 6 1 1 7 7 7 3 Exocyst complex component Sec5 PPR_2 PF13041.6 EFC50661.1 - 2.3e-52 174.9 19.0 1.8e-09 37.7 0.1 9.9 4 2 6 10 10 10 9 PPR repeat family PPR PF01535.20 EFC50661.1 - 3.6e-45 149.1 26.0 2e-06 27.7 0.1 12.3 12 0 0 12 12 12 9 PPR repeat PPR_3 PF13812.6 EFC50661.1 - 1.9e-42 143.1 14.2 9.1e-11 41.7 0.0 7.9 6 1 2 8 8 8 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 EFC50661.1 - 1.7e-37 126.8 6.9 4.6e-07 29.4 0.0 11.1 12 0 0 12 12 12 8 PPR repeat PPR_long PF17177.4 EFC50661.1 - 8.6e-29 100.4 5.9 1.4e-08 34.4 0.4 4.0 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 EFC50661.1 - 4.5e-05 23.9 0.5 2.2 8.8 0.0 5.7 5 1 2 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50661.1 - 5e-05 23.8 0.0 14 6.8 0.0 6.0 6 1 1 7 7 7 0 Tetratricopeptide repeat ATP13 PF12921.7 EFC50661.1 - 0.0001 22.1 0.1 0.036 13.9 0.0 4.4 3 2 2 5 5 5 1 Mitochondrial ATPase expression DUF3368 PF11848.8 EFC50661.1 - 0.0051 16.6 0.7 0.06 13.1 0.0 3.3 5 0 0 5 5 5 1 Domain of unknown function (DUF3368) TPR_12 PF13424.6 EFC50661.1 - 0.007 16.6 0.3 0.98 9.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Phage_ABA_S PF18066.1 EFC50661.1 - 0.03 15.0 0.1 5.6 7.7 0.0 3.8 3 1 0 4 4 4 0 Phage ABA sandwich domain Wzy_C_2 PF11846.8 EFC50661.1 - 0.05 13.5 1.6 48 3.8 0.0 4.4 4 1 1 5 5 5 0 Virulence factor membrane-bound polymerase, C-terminal YfdX PF10938.8 EFC50661.1 - 0.089 12.7 0.0 0.59 10.0 0.0 2.4 2 0 0 2 2 2 0 YfdX protein JmjC PF02373.22 EFC50662.1 - 8.6e-11 42.3 0.0 2.2e-10 41.0 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 EFC50662.1 - 1.4e-08 34.9 23.2 1.4e-08 34.9 23.2 2.9 3 0 0 3 3 3 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Complex1_LYR PF05347.15 EFC50663.1 - 1.7e-05 24.8 0.1 6.2e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) ELO PF01151.18 EFC50665.1 - 2.1e-47 161.8 17.0 2.5e-47 161.5 17.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Clat_adaptor_s PF01217.20 EFC50666.1 - 3.4e-51 172.9 5.4 4e-51 172.7 5.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Brix PF04427.18 EFC50667.1 - 7.4e-36 124.1 1.5 7.4e-36 124.1 1.5 1.7 2 0 0 2 2 2 1 Brix domain NMT1_3 PF16868.5 EFC50667.1 - 0.07 12.5 0.0 0.099 12.0 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family RNA_pol_Rpc4 PF05132.14 EFC50668.1 - 0.012 16.1 17.3 0.012 16.1 17.3 3.6 3 0 0 3 3 3 0 RNA polymerase III RPC4 DUF2126 PF09899.9 EFC50668.1 - 0.14 10.2 5.0 0.27 9.2 5.0 1.4 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) GAS PF13851.6 EFC50669.1 - 0.0028 17.0 1.5 0.0036 16.7 0.4 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding HR1 PF02185.16 EFC50669.1 - 0.04 14.0 1.2 0.055 13.6 0.1 1.7 2 0 0 2 2 2 0 Hr1 repeat DUF1700 PF08006.11 EFC50669.1 - 0.04 13.5 0.3 0.049 13.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) CSN5_C PF18323.1 EFC50669.1 - 0.047 14.6 2.7 0.082 13.8 0.2 2.0 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain DUF1493 PF07377.12 EFC50669.1 - 0.061 13.8 0.6 0.074 13.5 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) DUF2087 PF09860.9 EFC50671.1 - 0.11 12.7 0.1 0.44 10.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) JSRP PF15312.6 EFC50672.1 - 0.029 14.3 0.1 0.058 13.3 0.1 1.4 1 0 0 1 1 1 0 Junctional sarcoplasmic reticulum protein Lipocalin_7 PF14651.6 EFC50672.1 - 0.35 10.8 2.3 5.2 7.0 0.0 2.9 3 0 0 3 3 3 0 Lipocalin / cytosolic fatty-acid binding protein family Hydrolase_4 PF12146.8 EFC50673.1 - 5.9e-08 32.3 0.0 8.5e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 EFC50673.1 - 3.1e-07 31.2 0.0 3.8e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 EFC50673.1 - 3.9e-07 30.0 0.0 7.7e-07 29.0 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Ndr PF03096.14 EFC50673.1 - 0.0041 15.9 0.1 0.01 14.5 0.0 1.7 2 1 0 2 2 2 1 Ndr family Abhydrolase_2 PF02230.16 EFC50673.1 - 0.039 13.7 0.0 0.072 12.9 0.0 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.18 EFC50673.1 - 0.045 13.3 0.0 0.081 12.5 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family SpmSyn_N PF17950.1 EFC50673.1 - 0.063 13.5 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 S-adenosylmethionine decarboxylase N -terminal Thioesterase PF00975.20 EFC50673.1 - 0.068 13.3 0.3 7.9 6.5 0.1 3.0 2 1 0 2 2 2 0 Thioesterase domain Sld5 PF05916.11 EFC50674.1 - 6.8e-13 49.0 0.0 1.2e-12 48.3 0.0 1.4 1 0 0 1 1 1 1 GINS complex protein Utp14 PF04615.13 EFC50675.1 - 1.3e-71 242.3 98.0 1.3e-71 242.3 98.0 3.1 1 1 2 3 3 3 1 Utp14 protein RNB PF00773.19 EFC50676.1 - 9.5e-101 337.4 0.2 9.5e-101 337.4 0.2 2.1 2 1 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 EFC50676.1 - 6.4e-18 64.6 0.1 3e-17 62.4 0.0 2.2 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 EFC50676.1 - 1.5e-14 53.7 1.1 4.2e-14 52.3 1.1 1.8 1 0 0 1 1 1 1 S1 domain PIN_4 PF13638.6 EFC50676.1 - 3.9e-13 49.8 1.3 3.9e-13 49.8 1.3 2.5 2 0 0 2 2 2 1 PIN domain Rrp44_CSD1 PF17216.3 EFC50676.1 - 4.4e-11 42.7 0.2 3.2e-09 36.7 0.1 2.8 2 0 0 2 2 2 1 Rrp44-like cold shock domain CSD2 PF17876.1 EFC50676.1 - 0.0012 18.9 0.0 0.053 13.7 0.0 3.2 2 0 0 2 2 2 1 Cold shock domain OB_RNB PF08206.11 EFC50676.1 - 0.098 12.3 0.0 0.41 10.4 0.0 2.0 1 0 0 1 1 1 0 Ribonuclease B OB domain Pkinase PF00069.25 EFC50677.1 - 1.3e-69 234.5 0.0 1.6e-69 234.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50677.1 - 1.3e-31 109.9 0.0 3.8e-31 108.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC50677.1 - 0.017 14.1 0.2 0.22 10.4 0.0 2.4 2 1 0 2 2 2 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 EFC50677.1 - 0.044 12.7 0.0 0.064 12.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase MCM_bind PF09739.9 EFC50678.1 - 1.1e-44 152.9 0.0 1.1e-43 149.6 0.0 1.9 1 1 0 1 1 1 1 Mini-chromosome maintenance replisome factor RUN PF02759.19 EFC50679.1 - 6.3e-10 39.1 0.1 2.5e-08 33.9 0.0 2.3 2 0 0 2 2 2 1 RUN domain PI_PP_I PF18363.1 EFC50679.1 - 1 9.6 4.6 1.1 9.5 0.2 3.0 3 1 0 3 3 3 0 Phosphoinositide phosphatase insertion domain BSD PF03909.17 EFC50679.1 - 3.1 7.9 7.7 2.3 8.3 1.0 3.6 3 0 0 3 3 3 0 BSD domain KH_5 PF13184.6 EFC50679.1 - 7 6.8 5.8 21 5.3 0.2 3.5 3 0 0 3 3 3 0 NusA-like KH domain Syntaxin PF00804.25 EFC50680.1 - 0.011 15.4 0.2 0.015 15.0 0.2 1.2 1 0 0 1 1 1 0 Syntaxin HeLo PF14479.6 EFC50680.1 - 0.029 14.2 0.1 0.034 14.0 0.1 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation LOH1CR12 PF10158.9 EFC50680.1 - 0.037 14.0 0.2 0.061 13.4 0.2 1.3 1 0 0 1 1 1 0 Tumour suppressor protein CLZ PF16526.5 EFC50680.1 - 0.13 12.6 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Casc1_N PF15927.5 EFC50681.1 - 2.7e-42 144.7 29.6 2.7e-42 144.7 29.6 2.1 1 1 1 2 2 2 1 Cancer susceptibility candidate 1 N-terminus MAP7 PF05672.11 EFC50681.1 - 0.0002 21.1 36.0 0.00029 20.6 36.0 1.3 1 0 0 1 1 1 1 MAP7 (E-MAP-115) family Otopetrin PF03189.13 EFC50681.1 - 0.08 11.7 2.2 0.11 11.3 2.2 1.2 1 0 0 1 1 1 0 Otopetrin Ndc1_Nup PF09531.10 EFC50681.1 - 0.14 10.8 3.9 0.15 10.7 3.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup BSP_II PF05432.11 EFC50681.1 - 0.25 11.0 22.5 0.41 10.3 22.5 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF966 PF06136.13 EFC50681.1 - 0.29 10.8 15.7 0.36 10.5 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DDRGK PF09756.9 EFC50681.1 - 0.41 10.2 32.3 1.1 8.9 32.3 1.8 1 0 0 1 1 1 0 DDRGK domain DUF5401 PF17380.2 EFC50681.1 - 0.64 8.0 25.1 0.91 7.5 25.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CDC27 PF09507.10 EFC50681.1 - 1.1 8.5 34.4 1.4 8.2 34.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 V_ATPase_I PF01496.19 EFC50681.1 - 1.1 7.0 16.6 1.5 6.7 16.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MDM1 PF15501.6 EFC50681.1 - 1.6 7.8 33.3 2.1 7.4 33.3 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 SRP-alpha_N PF04086.13 EFC50681.1 - 1.9 8.4 24.2 2.7 7.8 24.2 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TMEM247 PF15444.6 EFC50681.1 - 3 7.8 13.2 4.9 7.1 13.2 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 SOBP PF15279.6 EFC50681.1 - 7.5 7.1 13.2 9.6 6.7 13.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein ORC6 PF05460.13 EFC50681.1 - 8.9 5.5 24.8 14 4.8 24.8 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) LRR_8 PF13855.6 EFC50682.1 - 1.7e-13 50.1 5.8 1.3e-07 31.2 1.6 3.6 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 EFC50682.1 - 4.3e-12 46.0 19.0 0.00018 21.8 1.5 5.5 2 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 EFC50682.1 - 1.7e-11 43.9 0.4 4.7e-11 42.5 0.4 1.8 1 0 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 EFC50682.1 - 0.01 15.8 14.8 2.9 8.2 0.0 5.4 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 EFC50682.1 - 0.1 13.2 14.3 11 7.0 0.1 6.5 6 1 0 6 6 6 0 Leucine Rich Repeat ESM4 PF15952.5 EFC50682.1 - 0.58 10.6 5.5 0.44 11.0 0.6 2.2 2 0 0 2 2 2 0 Enhancer of split M4 family TspO_MBR PF03073.15 EFC50683.1 - 1.1e-19 70.8 21.3 1.4e-19 70.5 21.3 1.1 1 0 0 1 1 1 1 TspO/MBR family DUF1282 PF06930.12 EFC50683.1 - 1.7 8.4 14.5 0.25 11.1 9.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) CENP-F_leu_zip PF10473.9 EFC50684.1 - 0.006 16.6 23.7 0.006 16.6 23.7 8.1 1 1 5 7 7 7 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 IFT57 PF10498.9 EFC50684.1 - 0.007 15.4 4.4 0.007 15.4 4.4 6.3 1 1 4 6 6 6 3 Intra-flagellar transport protein 57 bZIP_1 PF00170.21 EFC50684.1 - 0.016 15.2 2.2 0.016 15.2 2.2 15.0 11 6 5 17 17 17 0 bZIP transcription factor UPF0242 PF06785.11 EFC50684.1 - 0.017 15.3 17.0 0.017 15.3 17.0 9.1 1 1 7 8 8 8 0 Uncharacterised protein family (UPF0242) N-terminus Rimk_N PF18030.1 EFC50684.1 - 4.3 7.8 7.8 2.6 8.5 0.1 4.0 4 0 0 4 4 4 0 RimK PreATP-grasp domain DUF1192 PF06698.11 EFC50684.1 - 6 7.0 21.0 0.5 10.5 0.2 5.7 6 0 0 6 6 6 0 Protein of unknown function (DUF1192) Clat_adaptor_s PF01217.20 EFC50685.1 - 5.9e-55 185.1 4.5 6.6e-55 185.0 4.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CRA PF06589.11 EFC50685.1 - 0.07 13.2 0.1 0.092 12.9 0.1 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) HSP70 PF00012.20 EFC50686.1 - 8.8e-59 199.2 4.7 8.8e-59 199.2 4.7 1.9 1 1 1 2 2 2 1 Hsp70 protein BAG6 PF12057.8 EFC50686.1 - 0.15 11.7 0.5 7.8 6.2 0.1 2.6 2 0 0 2 2 2 0 BCL2-associated athanogene 6 HSP70 PF00012.20 EFC50687.1 - 4.4e-28 97.8 0.0 4.8e-28 97.7 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein FKBP_C PF00254.28 EFC50688.1 - 5.5e-26 90.7 0.1 6.8e-26 90.4 0.1 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase BOP1NT PF08145.12 EFC50690.1 - 8.7e-72 242.2 10.8 8.7e-72 242.2 10.8 2.7 3 0 0 3 3 3 1 BOP1NT (NUC169) domain WD40 PF00400.32 EFC50690.1 - 1.5e-24 85.7 4.8 3.1e-08 34.1 0.1 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat eIF2A PF08662.11 EFC50690.1 - 0.00038 20.4 0.2 0.0012 18.8 0.2 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 EFC50690.1 - 0.0032 17.7 1.3 1.7 9.0 0.0 4.1 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 EFC50690.1 - 0.59 9.5 39.8 0.096 12.1 4.4 2.5 2 0 0 2 2 2 0 SDA1 CDC73_C PF05179.14 EFC50692.1 - 6.8e-43 146.1 0.2 6.8e-43 146.1 0.2 2.0 2 1 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal Imm43 PF15570.6 EFC50693.1 - 1.3 9.0 8.0 0.81 9.7 5.0 2.1 1 1 1 2 2 2 0 Immunity protein 43 STAT_alpha PF01017.20 EFC50693.1 - 2.6 7.9 29.0 0.64 9.9 11.1 2.1 1 1 1 2 2 2 0 STAT protein, all-alpha domain RIC1 PF07064.13 EFC50694.1 - 4.4e-28 98.4 0.6 1.2e-27 97.0 0.6 1.7 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 EFC50694.1 - 2e-06 28.0 1.0 0.2 12.0 0.1 5.3 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC50694.1 - 0.0044 17.8 0.0 1.7e+02 3.3 0.0 5.4 5 0 0 5 5 5 0 WD domain, G-beta repeat Retrotrans_gag PF03732.17 EFC50694.1 - 0.65 10.3 3.5 3.9 7.8 0.1 3.5 3 0 0 3 3 3 0 Retrotransposon gag protein Rep_fac-A_C PF08646.10 EFC50695.1 - 0.12 12.2 0.1 0.12 12.2 0.1 2.9 3 0 0 3 3 3 0 Replication factor-A C terminal domain MORN PF02493.20 EFC50696.1 - 3.1e-13 48.7 34.5 5.1e-05 22.9 0.1 7.5 8 0 0 8 8 8 5 MORN repeat VPS9 PF02204.18 EFC50696.1 - 0.00014 22.0 0.1 0.00045 20.4 0.1 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF1828 PF08861.10 EFC50696.1 - 2.1 8.7 5.1 2.7 8.4 0.2 3.6 3 1 1 4 4 4 0 Domain of unknown function DUF1828 ABC_tran PF00005.27 EFC50697.1 - 1.5e-42 145.3 13.3 3.4e-23 82.7 0.0 4.3 3 1 1 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 EFC50697.1 - 2.7e-22 78.6 5.2 2.7e-22 78.6 5.2 4.6 4 0 0 4 4 4 1 ABC transporter AAA_21 PF13304.6 EFC50697.1 - 4.2e-14 53.1 6.4 0.015 15.1 0.5 4.7 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC50697.1 - 6e-11 42.2 0.1 0.007 15.8 0.0 3.9 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA PF00004.29 EFC50697.1 - 3e-07 30.9 1.2 0.005 17.3 0.0 4.4 3 2 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 EFC50697.1 - 3.8e-07 30.2 0.1 0.0016 18.4 0.0 2.9 2 1 0 2 2 2 2 RsgA GTPase AAA_33 PF13671.6 EFC50697.1 - 3.7e-06 27.1 0.1 0.18 12.0 0.0 3.8 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 EFC50697.1 - 5.7e-06 26.4 0.0 0.09 12.7 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_16 PF13191.6 EFC50697.1 - 8e-06 26.3 0.4 0.088 13.2 0.0 3.4 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 EFC50697.1 - 2.8e-05 24.4 0.0 0.097 12.9 0.0 3.5 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 EFC50697.1 - 4.5e-05 23.7 5.0 0.061 13.6 0.0 4.1 4 0 0 4 4 3 2 AAA domain AAA_29 PF13555.6 EFC50697.1 - 4.5e-05 23.1 0.2 0.018 14.8 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 EFC50697.1 - 4.7e-05 23.2 0.0 0.01 15.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 EFC50697.1 - 7.2e-05 22.6 0.0 0.35 10.6 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EFC50697.1 - 8.3e-05 23.1 7.4 0.039 14.5 0.0 5.0 5 1 0 5 5 5 1 AAA domain MMR_HSR1 PF01926.23 EFC50697.1 - 0.0001 22.3 0.0 0.11 12.6 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 EFC50697.1 - 0.00013 22.4 0.1 0.1 13.0 0.0 3.6 3 0 0 3 3 3 1 RNA helicase NB-ARC PF00931.22 EFC50697.1 - 0.00024 20.4 0.0 0.36 10.0 0.0 2.9 2 0 0 2 2 2 2 NB-ARC domain AAA_5 PF07728.14 EFC50697.1 - 0.00066 19.7 2.0 0.67 9.9 0.0 4.0 5 1 1 6 6 3 1 AAA domain (dynein-related subfamily) SRP54 PF00448.22 EFC50697.1 - 0.0014 18.3 0.0 0.5 10.0 0.0 2.9 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 EFC50697.1 - 0.0017 18.3 0.2 1.3 8.9 0.0 3.2 3 0 0 3 3 3 1 NTPase AAA_19 PF13245.6 EFC50697.1 - 0.0019 18.6 2.0 0.27 11.6 0.0 3.5 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 EFC50697.1 - 0.0023 17.9 0.0 3 7.9 0.0 3.6 3 0 0 3 3 2 1 AAA domain Roc PF08477.13 EFC50697.1 - 0.0049 17.1 0.0 3 8.1 0.0 3.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 EFC50697.1 - 0.0059 16.6 0.2 2.2 8.3 0.0 2.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 EFC50697.1 - 0.0077 15.8 0.1 0.35 10.4 0.0 2.8 2 0 0 2 2 2 1 P-loop containing dynein motor region MobB PF03205.14 EFC50697.1 - 0.048 13.6 1.7 18 5.2 0.0 3.7 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 EFC50697.1 - 0.076 12.6 0.0 1.6 8.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 EFC50697.1 - 0.093 12.5 0.0 1.5 8.5 0.0 2.5 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_23 PF13476.6 EFC50697.1 - 0.11 13.0 0.0 0.11 13.0 0.0 5.7 4 2 1 5 5 2 0 AAA domain Dynamin_N PF00350.23 EFC50697.1 - 0.41 10.7 0.0 0.41 10.7 0.0 5.1 4 2 1 5 5 4 0 Dynamin family DUF87 PF01935.17 EFC50697.1 - 1.4 8.9 0.0 1.4 8.9 0.0 4.7 5 1 0 5 5 3 0 Helicase HerA, central domain LSM PF01423.22 EFC50698.1 - 3.9e-17 61.7 0.1 4.9e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain Glyoxalase PF00903.25 EFC50700.1 - 2.2e-09 37.6 0.0 2.6e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 EFC50700.1 - 6.4e-06 26.1 0.0 1.5e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 EFC50700.1 - 9.3e-06 26.4 0.0 1e-05 26.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain zf-Mss51 PF13824.6 EFC50700.1 - 0.019 15.0 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 TruB_C PF09142.11 EFC50700.1 - 0.054 13.3 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 tRNA Pseudouridine synthase II, C terminal Cyt-b5 PF00173.28 EFC50701.1 - 8.8e-37 125.1 0.2 3.1e-17 62.5 0.0 2.0 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DUF3253 PF11625.8 EFC50701.1 - 0.045 14.0 0.0 0.069 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3253) FYRC PF05965.14 EFC50701.1 - 0.14 12.3 0.0 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 F/Y rich C-terminus Aldedh PF00171.22 EFC50702.1 - 8.7e-147 489.4 0.0 1e-146 489.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Kelch_4 PF13418.6 EFC50703.1 - 8e-27 93.0 3.3 5.9e-06 26.2 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 EFC50703.1 - 9.7e-23 79.9 0.3 0.00031 21.0 0.0 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 EFC50703.1 - 1.3e-22 79.3 0.6 0.00041 20.3 0.0 5.7 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 EFC50703.1 - 2e-16 59.3 2.0 3.8e-06 26.4 0.0 5.3 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 EFC50703.1 - 5.1e-15 55.2 5.1 4.6e-05 23.5 0.1 6.4 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 EFC50703.1 - 1.7e-10 40.5 4.0 0.00025 20.9 0.3 5.0 5 0 0 5 5 5 2 Kelch motif HHH_5 PF14520.6 EFC50704.1 - 3.5e-09 37.1 1.6 4.7e-09 36.7 1.6 1.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain RNA_pol_A_CTD PF03118.15 EFC50704.1 - 0.0037 17.0 0.2 0.006 16.3 0.2 1.4 1 0 0 1 1 1 1 Bacterial RNA polymerase, alpha chain C terminal domain HHH PF00633.23 EFC50704.1 - 0.048 13.5 0.0 0.13 12.2 0.0 1.8 1 1 1 2 2 2 0 Helix-hairpin-helix motif Pkinase PF00069.25 EFC50705.1 - 0.00037 20.0 0.1 0.0023 17.4 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain CoA_binding PF02629.19 EFC50706.1 - 3.7e-27 94.8 0.4 3.7e-27 94.8 0.4 1.7 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 EFC50706.1 - 1e-22 80.6 0.1 1.8e-22 79.8 0.1 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 EFC50706.1 - 1.8e-07 31.0 0.0 3.1e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain HMGL-like PF00682.19 EFC50707.1 - 8e-80 268.2 0.0 1.2e-79 267.6 0.0 1.3 1 0 0 1 1 1 1 HMGL-like Oxidored_FMN PF00724.20 EFC50707.1 - 0.0016 17.8 0.2 0.0072 15.6 0.0 2.1 3 0 0 3 3 3 1 NADH:flavin oxidoreductase / NADH oxidase family FAD-SLDH PF12318.8 EFC50707.1 - 0.21 11.6 0.0 0.47 10.5 0.0 1.5 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF3666 PF12408.8 EFC50707.1 - 4.9 6.4 5.5 0.66 9.2 0.2 2.3 3 0 0 3 3 3 0 Ribose-5-phosphate isomerase Band_7 PF01145.25 EFC50709.1 - 1.7e-28 99.9 2.4 2.2e-28 99.5 2.4 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 EFC50709.1 - 0.00012 21.3 4.0 0.00014 21.0 4.0 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial DUF1191 PF06697.12 EFC50709.1 - 0.02 14.7 0.0 0.082 12.7 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1191) DeoRC PF00455.22 EFC50709.1 - 0.06 13.3 1.0 0.12 12.3 1.0 1.5 1 0 0 1 1 1 0 DeoR C terminal sensor domain UDPGP PF01704.18 EFC50710.1 - 2.1e-37 128.8 0.3 2.3e-37 128.7 0.3 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Ribonuc_P_40 PF08584.11 EFC50711.1 - 3.8e-14 52.6 9.8 6.9e-13 48.5 9.8 2.2 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit Cnd1 PF12717.7 EFC50711.1 - 0.41 10.7 6.5 0.057 13.5 1.7 2.0 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 BNIP2 PF12496.8 EFC50711.1 - 4.7 7.6 7.5 0.45 10.9 2.1 2.1 2 1 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Secretin_N_2 PF07655.13 EFC50711.1 - 9 6.9 13.7 0.068 13.7 1.9 2.8 3 0 0 3 3 3 0 Secretin N-terminal domain DEAD PF00270.29 EFC50712.1 - 3e-44 150.9 2.1 6.1e-43 146.6 0.0 3.5 3 1 1 4 4 4 1 DEAD/DEAH box helicase Helicase_C PF00271.31 EFC50712.1 - 3.4e-24 85.3 1.2 2e-23 82.9 0.0 2.8 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 EFC50712.1 - 5.5e-06 26.5 0.8 1.8e-05 24.9 0.8 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Ribosomal_L17 PF01196.19 EFC50713.1 - 8.6e-27 93.9 2.2 9.4e-27 93.8 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L17 Pox_MCEL PF03291.16 EFC50713.1 - 0.018 14.2 0.2 0.02 14.0 0.2 1.1 1 0 0 1 1 1 0 mRNA capping enzyme HSP70 PF00012.20 EFC50714.1 - 7e-120 401.0 6.9 7e-120 401.0 6.9 2.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 EFC50714.1 - 4.5e-11 42.1 0.8 4e-10 39.0 0.2 2.3 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 EFC50714.1 - 2.5e-05 24.1 0.5 0.00013 21.8 0.1 2.2 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DUF1646 PF07854.12 EFC50714.1 - 0.15 11.4 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1646) FIVAR PF07554.13 EFC50714.1 - 0.57 11.0 8.6 2 9.2 6.8 2.7 2 0 0 2 2 2 0 FIVAR domain Phage_TAC_10 PF10963.8 EFC50714.1 - 0.6 10.3 5.9 2.2 8.5 0.4 3.9 5 0 0 5 5 5 0 Phage tail assembly chaperone HMG_box PF00505.19 EFC50715.1 - 3.2e-34 117.2 12.0 2.6e-17 63.0 0.4 4.1 4 0 0 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 EFC50715.1 - 2e-22 79.6 5.9 5.7e-11 42.9 0.2 3.5 3 0 0 3 3 3 3 HMG-box domain Ccdc124 PF06244.12 EFC50715.1 - 0.00024 21.7 5.2 0.13 12.8 0.0 3.3 2 1 1 3 3 3 2 Coiled-coil domain-containing protein 124 /Oxs1 Protamine_like PF06382.11 EFC50715.1 - 0.0018 18.4 3.9 0.013 15.7 0.4 2.8 2 1 1 3 3 3 1 Protamine and protamine like COX4 PF02936.14 EFC50715.1 - 0.57 10.2 5.1 6 6.9 0.8 2.6 1 1 1 2 2 2 0 Cytochrome c oxidase subunit IV Aminotran_5 PF00266.19 EFC50716.1 - 2.9e-27 95.6 0.0 4.8e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V ATP_bind_3 PF01171.20 EFC50716.1 - 1.8e-17 63.7 0.0 3.2e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 PP-loop family RhoGEF67_u2 PF16614.5 EFC50716.1 - 0.099 12.7 1.5 6.4 6.9 0.2 2.8 3 0 0 3 3 3 0 Unstructured region two on RhoGEF 6 and 7 TAF4 PF05236.14 EFC50717.1 - 6.6e-23 81.8 12.8 6.6e-23 81.8 12.8 1.9 2 0 0 2 2 2 1 Transcription initiation factor TFIID component TAF4 family CRM1_C PF08767.11 EFC50718.1 - 6.9e-06 25.5 2.6 6.9e-06 25.5 2.6 4.4 4 1 0 5 5 5 1 CRM1 C terminal IBN_N PF03810.19 EFC50718.1 - 0.023 14.6 0.1 0.023 14.6 0.1 3.8 4 0 0 4 4 4 0 Importin-beta N-terminal domain DUF2228 PF10228.9 EFC50718.1 - 0.22 11.2 5.2 0.033 14.0 0.8 1.8 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) Topoisom_I PF01028.20 EFC50720.1 - 3.4e-97 324.2 8.1 3.4e-97 324.2 8.1 1.9 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 EFC50720.1 - 5.5e-90 300.6 5.0 5.5e-90 300.6 5.0 2.3 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 EFC50720.1 - 1.8e-29 101.4 1.6 5.3e-29 99.9 1.6 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain PI3K_P85_iSH2 PF16454.5 EFC50720.1 - 0.94 9.1 18.0 2.5 7.7 0.2 3.8 4 0 0 4 4 4 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF2884 PF11101.8 EFC50720.1 - 7.4 6.0 10.1 14 5.1 0.0 3.9 4 1 0 5 5 5 0 Protein of unknown function (DUF2884) LSM PF01423.22 EFC50721.1 - 1e-15 57.1 0.1 1.2e-15 56.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 EFC50721.1 - 8.3e-07 29.1 0.0 9.7e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 EFC50721.1 - 0.058 13.5 0.0 0.063 13.4 0.0 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain IMPDH PF00478.25 EFC50722.1 - 6.6e-90 301.6 0.1 2e-89 300.0 0.1 1.6 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 EFC50722.1 - 6e-09 35.7 2.6 6.6e-09 35.6 0.4 2.2 3 0 0 3 3 3 1 Nitronate monooxygenase FMN_dh PF01070.18 EFC50722.1 - 1.4e-08 34.2 0.6 6.4e-08 32.0 0.6 1.9 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 EFC50722.1 - 2.6e-06 27.0 0.2 0.00064 19.3 0.1 3.2 2 1 0 2 2 2 1 Histidine biosynthesis protein DHO_dh PF01180.21 EFC50722.1 - 4.2e-05 22.9 0.6 0.00024 20.4 0.1 2.2 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase Glu_synthase PF01645.17 EFC50722.1 - 5.4e-05 22.5 0.5 8e-05 21.9 0.5 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 EFC50722.1 - 0.00022 20.7 2.5 0.001 18.5 1.0 2.0 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 EFC50722.1 - 0.0053 16.2 0.1 0.33 10.3 0.0 2.4 2 1 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator DUF561 PF04481.12 EFC50722.1 - 0.024 13.8 0.1 0.14 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF561) TMP-TENI PF02581.17 EFC50722.1 - 0.043 13.1 0.2 0.1 11.9 0.2 1.7 1 1 0 1 1 1 0 Thiamine monophosphate synthase Dus PF01207.17 EFC50722.1 - 0.046 12.8 0.4 0.92 8.5 0.0 2.2 1 1 1 2 2 2 0 Dihydrouridine synthase (Dus) Noc2 PF03715.13 EFC50723.1 - 5.7e-88 295.0 8.7 5.7e-88 295.0 8.7 2.0 2 0 0 2 2 2 1 Noc2p family Nop14 PF04147.12 EFC50723.1 - 0.032 12.5 56.8 0.04 12.1 22.2 3.2 2 1 1 3 3 3 0 Nop14-like family HEAT PF02985.22 EFC50723.1 - 0.084 13.2 0.7 13 6.3 0.1 2.9 2 0 0 2 2 2 0 HEAT repeat MCPVI PF02993.14 EFC50723.1 - 0.4 10.5 3.5 1.1 9.1 3.5 1.7 1 0 0 1 1 1 0 Minor capsid protein VI DNA_ligase_A_N PF04675.14 EFC50723.1 - 4.8 7.5 11.3 1.6 9.0 3.7 3.3 4 0 0 4 4 4 0 DNA ligase N terminus ANAPC4_WD40 PF12894.7 EFC50724.1 - 1.4e-08 34.9 0.7 0.64 10.3 0.0 5.3 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC50724.1 - 0.0023 18.7 6.9 23 6.1 0.0 5.7 6 0 0 6 6 6 1 WD domain, G-beta repeat CNH PF00780.22 EFC50724.1 - 0.006 16.2 0.9 0.035 13.7 0.0 2.4 2 1 1 3 3 3 1 CNH domain WD40_like PF17005.5 EFC50724.1 - 0.014 14.8 3.6 0.024 14.0 0.5 2.8 3 1 0 3 3 3 0 WD40-like domain APG6 PF04111.12 EFC50725.1 - 2.8e-51 174.0 0.1 2.8e-51 174.0 0.1 1.9 2 0 0 2 2 2 1 Apg6 BARA domain APG6_N PF17675.1 EFC50725.1 - 7.4e-16 58.9 25.8 7.4e-16 58.9 25.8 2.4 2 0 0 2 2 2 1 Apg6 coiled-coil region HOOK PF05622.12 EFC50726.1 - 0.0033 15.7 17.2 0.0044 15.3 17.2 1.2 1 0 0 1 1 1 1 HOOK protein CENP-F_leu_zip PF10473.9 EFC50726.1 - 0.0041 17.1 18.4 0.038 14.0 3.1 2.8 2 1 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_2 PF07716.15 EFC50726.1 - 0.026 14.6 15.9 0.24 11.5 1.9 3.5 2 1 0 3 3 3 0 Basic region leucine zipper PspA_IM30 PF04012.12 EFC50726.1 - 0.048 13.2 12.6 0.25 10.9 2.6 2.3 1 1 1 2 2 2 0 PspA/IM30 family TPR_MLP1_2 PF07926.12 EFC50726.1 - 0.057 13.5 15.7 0.18 11.9 3.8 2.6 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Macoilin PF09726.9 EFC50726.1 - 0.061 11.9 28.0 0.08 11.5 28.0 1.2 1 0 0 1 1 1 0 Macoilin family DUF1192 PF06698.11 EFC50726.1 - 0.13 12.4 2.3 7.9 6.6 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1192) DUF4407 PF14362.6 EFC50726.1 - 0.13 11.5 3.3 0.18 11.1 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ACCA PF03255.14 EFC50726.1 - 0.75 9.7 10.0 0.48 10.3 1.9 2.7 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF4972 PF16342.5 EFC50726.1 - 0.75 9.5 8.3 0.27 10.9 3.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4972) Myb_DNA-bind_4 PF13837.6 EFC50726.1 - 1 9.8 10.4 0.11 12.9 1.8 2.6 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain DUF2205 PF10224.9 EFC50726.1 - 1.1 9.3 12.4 0.17 11.9 3.7 2.6 2 0 0 2 2 2 0 Short coiled-coil protein Retrotrans_gag PF03732.17 EFC50726.1 - 2.4 8.5 7.9 0.68 10.2 2.8 2.8 2 1 1 3 3 3 0 Retrotransposon gag protein ABC_tran_CTD PF16326.5 EFC50726.1 - 2.7 8.3 12.7 3.3 8.0 1.6 3.2 2 1 0 2 2 2 0 ABC transporter C-terminal domain bZIP_1 PF00170.21 EFC50726.1 - 3 8.0 21.5 9.7 6.4 4.8 3.7 2 1 0 2 2 2 0 bZIP transcription factor CLZ PF16526.5 EFC50726.1 - 3.9 7.9 14.8 3.7 8.0 5.8 3.0 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Myc-LZ PF02344.15 EFC50726.1 - 4.8 7.4 9.5 3 8.0 1.1 3.6 3 0 0 3 3 3 0 Myc leucine zipper domain DivIC PF04977.15 EFC50726.1 - 4.9 7.0 16.6 13 5.6 1.7 3.7 2 1 0 3 3 3 0 Septum formation initiator GTP-bdg_M PF16360.5 EFC50726.1 - 6 7.5 5.7 18 6.0 0.5 3.2 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region FAM76 PF16046.5 EFC50726.1 - 8.1 5.7 29.0 0.62 9.4 23.2 1.9 1 1 1 2 2 1 0 FAM76 protein Ribonuc_2-5A PF06479.12 EFC50727.1 - 1.9e-30 105.7 0.7 3.3e-30 104.9 0.7 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 EFC50727.1 - 1.3e-29 103.4 0.1 2.4e-29 102.5 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50727.1 - 3e-15 56.2 0.0 1e-14 54.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC50727.1 - 2.6e-08 33.5 0.0 4.4e-08 32.8 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 EFC50727.1 - 6.2e-07 29.0 0.1 1.6e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 EFC50727.1 - 0.00063 19.7 0.1 0.00095 19.2 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 EFC50727.1 - 0.0031 16.5 0.4 0.019 14.0 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain SBBP PF06739.11 EFC50727.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Beta-propeller repeat Myosin_head PF00063.21 EFC50728.1 - 3.3e-206 686.6 13.4 3.3e-206 686.6 13.4 2.5 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 EFC50728.1 - 6.2e-132 436.8 41.2 9.1e-46 155.9 1.2 6.0 6 0 0 6 6 6 4 Unconventional myosin tail, actin- and lipid-binding PH_3 PF14593.6 EFC50728.1 - 3.6e-12 46.3 19.5 5.9e-05 23.1 0.4 5.2 5 0 0 5 5 5 4 PH domain hSac2 PF12456.8 EFC50728.1 - 0.00071 19.3 1.2 1.7 8.4 0.0 4.2 4 0 0 4 4 4 1 Inositol phosphatase DUF3841 PF12952.7 EFC50728.1 - 0.016 15.0 1.9 9.2 6.0 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3841) AAA_16 PF13191.6 EFC50728.1 - 0.029 14.7 0.0 0.089 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 EFC50728.1 - 0.065 13.5 1.1 0.44 10.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 EFC50728.1 - 0.078 13.5 1.1 0.41 11.1 0.0 2.9 2 0 0 2 2 2 0 ABC transporter VP9 PF09625.10 EFC50728.1 - 0.35 11.1 2.2 2.5 8.4 0.0 3.3 4 0 0 4 4 3 0 VP9 protein DUF3399 PF11879.8 EFC50728.1 - 0.55 10.6 2.3 0.88 9.9 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) IQ PF00612.27 EFC50728.1 - 2.8 8.0 5.8 0.28 11.1 0.8 2.1 2 0 0 2 2 2 0 IQ calmodulin-binding motif TPR_12 PF13424.6 EFC50730.1 - 3.8e-65 216.1 16.3 1.3e-13 51.0 0.2 7.9 5 2 3 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50730.1 - 1.5e-45 151.9 5.6 1.2e-06 28.2 0.0 11.5 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50730.1 - 5.5e-24 82.3 36.1 0.00044 20.2 0.1 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50730.1 - 9.7e-23 79.0 39.0 0.00013 21.6 0.4 10.6 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50730.1 - 4.1e-19 67.1 20.9 0.0099 15.9 0.3 9.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50730.1 - 3.4e-15 54.9 19.5 0.018 15.0 0.1 8.5 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50730.1 - 2.1e-10 40.2 3.1 0.014 15.7 0.0 7.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC50730.1 - 4.3e-10 39.5 0.0 1.3e-06 28.0 0.0 3.1 1 1 3 4 4 4 2 MalT-like TPR region SNAP PF14938.6 EFC50730.1 - 8.8e-06 25.3 3.8 0.0024 17.4 0.3 3.4 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 EFC50730.1 - 1.1e-05 25.0 15.8 0.75 9.5 0.1 8.0 6 1 1 7 7 7 3 TPR repeat TPR_19 PF14559.6 EFC50730.1 - 0.00014 22.3 0.2 0.51 10.9 0.0 3.8 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50730.1 - 0.00022 21.6 12.8 0.31 11.8 0.0 6.2 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50730.1 - 0.007 17.0 0.0 0.67 10.7 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC50730.1 - 0.048 13.1 1.4 19 4.8 0.0 4.3 4 0 0 4 4 4 0 SHNi-TPR MIT PF04212.18 EFC50730.1 - 1.2 9.2 19.6 1.6 8.8 0.0 6.9 8 0 0 8 8 8 0 MIT (microtubule interacting and transport) domain Aminotran_3 PF00202.21 EFC50731.1 - 2e-98 329.7 0.0 2.3e-98 329.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Mcl1_mid PF12341.8 EFC50732.1 - 5.2e-21 75.3 0.3 1.9e-17 63.6 0.1 3.5 2 1 0 2 2 2 2 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 EFC50732.1 - 5.6e-05 23.4 0.9 8.6 6.7 0.0 5.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain RIG-I_C PF18119.1 EFC50732.1 - 0.043 13.8 0.1 0.16 12.0 0.1 2.0 1 0 0 1 1 1 0 RIG-I receptor C-terminal domain Pep1_7 PF17232.2 EFC50733.1 - 0.53 10.8 4.8 2.2 8.8 2.6 2.8 2 0 0 2 2 2 0 Elicitor peptide 1-7 PP_kinase_N PF13089.6 EFC50733.1 - 1.6 9.1 5.1 12 6.3 1.2 2.7 2 0 0 2 2 2 0 Polyphosphate kinase N-terminal domain Prenyltransf PF01255.19 EFC50734.1 - 8e-68 228.3 0.8 9e-68 228.1 0.8 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Myb_DNA-binding PF00249.31 EFC50735.1 - 1.6e-39 133.8 5.0 8.9e-20 70.6 1.2 2.0 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 EFC50735.1 - 6.8e-31 106.3 5.4 1.1e-18 67.2 0.4 2.0 1 1 1 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 EFC50735.1 - 2.5e-09 36.9 0.3 9.1e-06 25.5 0.1 2.1 1 1 1 2 2 2 2 Myb DNA-binding like SLIDE PF09111.10 EFC50735.1 - 1.2e-05 25.3 0.2 0.092 12.8 0.0 2.3 1 1 1 2 2 2 2 SLIDE SANT_DAMP1_like PF16282.5 EFC50735.1 - 0.00024 21.2 0.5 0.71 10.1 0.0 2.3 1 1 1 2 2 2 2 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.8 EFC50735.1 - 0.0004 20.4 0.5 0.15 12.2 0.5 2.2 1 1 0 1 1 1 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF4085 PF13315.6 EFC50735.1 - 0.0021 17.7 0.3 0.57 9.8 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF4085) Myb_DNA-bind_2 PF08914.11 EFC50735.1 - 0.0043 17.2 0.8 3.6 7.8 0.1 2.7 1 1 1 2 2 2 2 Rap1 Myb domain DUF5591 PF17884.1 EFC50735.1 - 0.038 13.9 0.1 0.27 11.1 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5591) Exo70 PF03081.15 EFC50735.1 - 0.13 11.3 1.2 6.8 5.6 0.2 2.0 1 1 1 2 2 2 0 Exo70 exocyst complex subunit Nore1-SARAH PF16517.5 EFC50735.1 - 0.26 11.2 3.2 0.54 10.2 0.0 2.5 3 0 0 3 3 3 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain HD PF01966.22 EFC50736.1 - 0.039 14.2 0.1 0.085 13.1 0.1 1.6 1 0 0 1 1 1 0 HD domain DUF3511 PF12023.8 EFC50736.1 - 0.046 13.5 0.2 0.1 12.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3511) MMR_HSR1 PF01926.23 EFC50737.1 - 6.2e-16 58.5 1.2 1.1e-13 51.3 0.0 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC50737.1 - 2.8e-09 36.7 0.0 2.5e-07 30.3 0.0 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC50737.1 - 1.1e-07 31.9 0.6 0.00013 21.9 0.0 2.6 1 1 1 2 2 2 2 RsgA GTPase cobW PF02492.19 EFC50737.1 - 0.014 15.0 1.0 0.21 11.2 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain WD40 PF00400.32 EFC50738.1 - 5.3e-10 39.7 2.1 1.1 10.3 0.0 6.2 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50738.1 - 1e-07 32.2 0.0 0.19 12.0 0.0 5.1 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Rav1p_C PF12234.8 EFC50739.1 - 5.8e-86 289.3 9.6 5.8e-86 289.3 9.6 2.6 3 0 0 3 3 3 1 RAVE protein 1 C terminal WD40 PF00400.32 EFC50739.1 - 1.4e-07 32.1 19.7 10 7.1 0.4 10.8 12 0 0 12 12 12 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50739.1 - 0.00015 22.0 0.5 1.9 8.8 0.0 5.3 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Methyltransf_FA PF12248.8 EFC50739.1 - 0.015 15.6 0.6 12 6.3 0.1 3.4 3 0 0 3 3 3 0 Farnesoic acid 0-methyl transferase BBS2_Mid PF14783.6 EFC50739.1 - 0.021 14.9 0.0 0.086 12.9 0.0 2.0 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region NTS_2 PF15448.6 EFC50739.1 - 0.13 12.7 1.6 38 4.8 0.0 3.2 2 0 0 2 2 2 0 N-terminal segments of P. falciparum erythrocyte membrane protein Roc PF08477.13 EFC50740.1 - 4.9e-15 55.8 0.0 6e-15 55.5 0.0 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC50740.1 - 3.8e-13 49.3 0.0 4.3e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.21 EFC50740.1 - 3.9e-07 29.7 0.0 4.2e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFC50740.1 - 8.1e-05 21.9 0.4 0.12 11.5 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 EFC50740.1 - 0.0021 17.5 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AIG1 PF04548.16 EFC50740.1 - 0.0072 15.7 0.0 0.0083 15.5 0.0 1.2 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 EFC50740.1 - 0.023 14.1 0.0 0.032 13.7 0.0 1.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit IIGP PF05049.13 EFC50740.1 - 0.057 12.5 0.0 0.074 12.1 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 EFC50740.1 - 0.09 12.9 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase NAD_binding_1 PF00175.21 EFC50741.1 - 9.3e-33 113.1 0.0 2.7e-32 111.7 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFC50741.1 - 6.9e-28 96.9 0.0 1.1e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 EFC50741.1 - 2e-05 24.8 0.0 0.0012 19.0 0.0 2.3 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_1 PF00667.20 EFC50742.1 - 3.4e-58 196.8 0.3 5.2e-58 196.2 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 EFC50742.1 - 6e-35 120.5 1.8 1.4e-34 119.4 1.4 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 EFC50742.1 - 3e-16 60.0 0.0 1.5e-15 57.8 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 EFC50742.1 - 0.0025 18.1 0.0 0.56 10.6 0.0 2.6 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain DUF2600 PF10776.9 EFC50742.1 - 0.041 12.8 0.2 0.38 9.6 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2600) NAD_binding_6 PF08030.12 EFC50742.1 - 0.054 13.6 0.0 0.42 10.7 0.0 2.2 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Flavodoxin_5 PF12724.7 EFC50742.1 - 0.058 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Plus-3 PF03126.18 EFC50743.1 - 2.3e-24 86.0 1.2 6e-24 84.7 1.2 1.8 1 0 0 1 1 1 1 Plus-3 domain Nop16 PF09420.10 EFC50744.1 - 6.8e-17 62.2 8.7 5e-13 49.6 0.7 2.2 1 1 1 2 2 2 2 Ribosome biogenesis protein Nop16 Ras PF00071.22 EFC50745.1 - 1.1e-47 161.6 0.0 1.3e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50745.1 - 1.8e-19 70.1 0.0 2.6e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50745.1 - 2.9e-06 26.8 0.0 4.6e-06 26.2 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family PBP_sp32 PF07222.12 EFC50746.1 - 0.077 12.5 3.1 0.11 11.9 3.1 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF5089 PF17002.5 EFC50746.1 - 3.4 7.5 8.2 0.34 10.8 1.6 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF5089) HAT PF02184.16 EFC50747.1 - 1.9e-21 75.7 45.3 3.3e-09 36.5 0.4 12.8 13 0 0 13 13 13 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 EFC50747.1 - 6.8e-18 63.8 0.0 0.35 11.8 0.2 9.5 6 3 4 10 10 10 4 Tetratricopeptide repeat Suf PF05843.14 EFC50747.1 - 1e-12 48.7 55.5 1.5e-09 38.3 7.7 7.5 2 1 3 5 5 5 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 EFC50747.1 - 1.3e-09 38.4 0.0 0.16 12.5 0.0 6.6 6 1 2 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50747.1 - 8.6e-06 25.6 0.3 2.5 8.5 0.0 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50747.1 - 1.6e-05 24.7 1.0 9.8 6.6 0.3 7.1 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50747.1 - 8.5e-05 22.7 1.7 1.1 9.8 0.0 5.6 7 0 0 7 7 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 EFC50747.1 - 0.00023 21.2 3.3 0.00023 21.2 3.3 7.4 7 2 0 7 7 7 2 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 EFC50747.1 - 0.018 15.3 7.9 4.2 7.7 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50747.1 - 0.039 14.6 0.0 2.2 9.0 0.0 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TAtT PF16811.5 EFC50747.1 - 2.1 7.5 7.5 5.2 6.3 1.9 3.6 2 1 0 2 2 2 0 TRAP transporter T-component TPR_6 PF13174.6 EFC50747.1 - 5 8.0 12.2 21 6.0 0.1 6.9 10 0 0 10 10 8 0 Tetratricopeptide repeat NTP_transferase PF00483.23 EFC50748.1 - 1e-54 185.8 0.0 1.4e-54 185.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 EFC50748.1 - 1.7e-13 49.7 5.7 2.5e-10 39.6 2.4 2.8 2 1 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 EFC50748.1 - 5.6e-12 46.3 0.0 7e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 EFC50748.1 - 0.00062 19.5 2.3 0.0029 17.3 2.3 2.2 1 0 0 1 1 1 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 EFC50748.1 - 0.0025 16.8 0.2 0.016 14.2 0.1 2.2 1 1 0 2 2 2 1 L-fucokinase CTP_transf_3 PF02348.19 EFC50748.1 - 0.072 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Cytidylyltransferase DUF4387 PF14330.6 EFC50748.1 - 0.092 13.5 0.0 1.1 10.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4387) TPR_12 PF13424.6 EFC50750.1 - 3e-31 107.5 1.9 1.6e-09 38.0 0.0 4.1 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50750.1 - 3e-23 81.0 0.0 1.1e-05 25.1 0.1 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50750.1 - 2.3e-20 71.5 10.4 1.5e-05 24.6 0.1 5.5 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50750.1 - 4.3e-19 67.0 12.2 0.0026 17.8 0.1 5.7 5 1 1 6 6 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50750.1 - 1.5e-13 49.8 9.5 0.007 16.5 0.0 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50750.1 - 1.7e-09 37.7 2.3 0.47 11.2 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50750.1 - 4e-08 32.7 0.1 0.71 10.0 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50750.1 - 7e-05 22.4 8.0 1.3 8.8 0.3 5.4 6 0 0 6 6 5 2 TPR repeat TPR_14 PF13428.6 EFC50750.1 - 0.00014 22.4 0.1 5.3 8.1 0.0 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50750.1 - 0.00032 21.3 0.7 12 6.6 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC50750.1 - 0.00055 19.4 0.0 0.017 14.6 0.0 2.3 1 1 1 2 2 2 1 MalT-like TPR region TPR_3 PF07720.12 EFC50750.1 - 0.00071 19.5 5.3 1.5 8.9 0.3 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat SRP_TPR_like PF17004.5 EFC50750.1 - 0.0011 19.0 2.5 0.015 15.3 0.7 2.9 2 1 0 2 2 2 1 Putative TPR-like repeat ANAPC3 PF12895.7 EFC50750.1 - 0.0057 16.9 3.5 1.3 9.3 0.6 3.8 2 2 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 EFC50750.1 - 0.0064 16.5 8.2 5.2 7.2 0.0 5.4 5 1 0 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 EFC50750.1 - 0.024 15.0 1.0 20 5.9 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat SPO22 PF08631.10 EFC50750.1 - 0.026 14.0 0.8 9.9 5.6 0.0 2.8 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like Zn_clus PF00172.18 EFC50751.1 - 2.1e-10 40.6 11.1 2.1e-10 40.6 11.1 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.6 EFC50751.1 - 0.054 13.1 5.6 0.11 12.0 5.6 1.5 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain ESR1_C PF12743.7 EFC50753.1 - 0.05 13.4 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Oestrogen-type nuclear receptor final C-terminal GST_N_3 PF13417.6 EFC50754.1 - 2.5e-10 40.6 0.0 4.3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 EFC50754.1 - 3.1e-09 36.9 1.0 8.6e-09 35.5 1.0 1.8 1 0 0 1 1 1 1 Glutaredoxin GST_N_4 PF17172.4 EFC50754.1 - 1.4e-08 35.4 0.0 3.1e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_2 PF13409.6 EFC50754.1 - 2.4e-07 31.0 0.0 5.2e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 EFC50754.1 - 0.0013 18.9 0.0 0.0029 17.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 EFC50754.1 - 0.0024 18.2 0.0 0.0038 17.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 EFC50754.1 - 0.0086 16.2 0.0 0.02 15.1 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 EFC50754.1 - 0.0095 15.9 0.1 0.03 14.3 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain TPR_12 PF13424.6 EFC50755.1 - 1.2e-40 137.6 5.9 3.1e-10 40.2 0.0 7.9 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50755.1 - 7.9e-30 101.4 21.1 0.004 16.9 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50755.1 - 4.2e-25 85.8 24.1 0.00021 21.1 0.0 10.1 11 0 0 11 11 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 EFC50755.1 - 3.2e-19 68.1 0.5 0.064 13.2 0.0 8.8 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50755.1 - 1.3e-14 53.1 9.8 0.78 9.9 0.0 9.7 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 EFC50755.1 - 5.4e-14 51.2 35.9 0.14 12.5 0.1 10.8 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_MalT PF17874.1 EFC50755.1 - 1.3e-10 41.2 0.0 0.037 13.4 0.0 4.8 2 2 0 4 4 4 3 MalT-like TPR region TPR_19 PF14559.6 EFC50755.1 - 3.2e-09 37.2 0.0 0.73 10.4 0.0 6.2 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50755.1 - 1e-07 32.5 0.0 9.1 7.0 0.7 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 EFC50755.1 - 1.3e-07 31.8 0.0 10 7.3 0.0 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 EFC50755.1 - 0.00068 20.1 12.4 22 5.9 0.0 7.7 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_17 PF13431.6 EFC50755.1 - 0.012 15.9 14.1 32 5.2 0.0 8.5 8 1 0 8 8 8 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 EFC50755.1 - 0.019 14.4 0.5 0.38 10.2 0.0 3.2 3 0 0 3 3 3 0 SHNi-TPR TPR_3 PF07720.12 EFC50755.1 - 0.45 10.6 10.0 3.6 7.7 0.2 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TLD PF07534.16 EFC50756.1 - 2.3e-24 86.2 7.6 3.1e-24 85.8 1.4 2.2 2 0 0 2 2 2 2 TLD Anemone_cytotox PF06369.12 EFC50756.1 - 0.034 13.8 0.1 0.059 13.0 0.1 1.4 1 0 0 1 1 1 0 Sea anemone cytotoxic protein WD40 PF00400.32 EFC50757.1 - 7.2e-20 71.0 14.9 6e-06 26.9 0.4 6.7 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50757.1 - 1e-19 70.6 0.1 4.5e-06 26.9 0.0 5.7 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 EFC50757.1 - 0.00011 21.7 0.3 0.52 9.6 0.0 3.5 4 0 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 EFC50757.1 - 0.00084 18.4 0.1 0.022 13.7 0.0 2.5 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 EFC50757.1 - 0.0057 16.3 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 PQQ-like domain eIF2A PF08662.11 EFC50757.1 - 0.015 15.2 0.1 0.92 9.4 0.0 2.8 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 EFC50757.1 - 0.061 13.3 0.3 1.8 8.6 0.0 3.1 3 0 0 3 3 3 0 PQQ enzyme repeat Nup160 PF11715.8 EFC50757.1 - 0.13 10.9 0.2 1.1 7.8 0.0 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Frtz PF11768.8 EFC50757.1 - 0.14 10.5 0.0 28 2.8 0.0 3.0 2 1 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Pkinase PF00069.25 EFC50759.1 - 1.2e-71 241.2 0.0 1.5e-71 240.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50759.1 - 6.5e-51 173.1 0.0 8.6e-51 172.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC50759.1 - 5.5e-07 28.7 2.0 6.1e-07 28.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 EFC50759.1 - 8.6e-05 22.0 0.1 0.00085 18.7 0.0 2.2 2 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 EFC50759.1 - 0.023 14.1 0.0 0.049 13.0 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 EFC50759.1 - 0.028 14.0 0.0 0.052 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 EFC50759.1 - 0.048 12.6 5.9 0.045 12.7 0.4 2.4 2 1 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 EFC50759.1 - 0.16 11.9 0.0 0.72 9.7 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family PQ-loop PF04193.14 EFC50760.1 - 2.3e-22 78.5 15.1 2.3e-12 46.5 2.3 3.0 3 0 0 3 3 3 2 PQ loop repeat COX2_TM PF02790.15 EFC50760.1 - 0.16 12.2 0.1 0.16 12.2 0.1 2.8 3 1 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain MtN3_slv PF03083.16 EFC50760.1 - 0.49 10.5 13.7 0.33 11.0 4.6 2.6 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange ERO1 PF04137.15 EFC50762.1 - 6.9e-108 361.0 4.9 8.3e-108 360.7 4.9 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) HMG_CoA_synt_C PF08540.10 EFC50763.1 - 7.5e-78 262.0 9.6 1.4e-77 261.1 9.6 1.4 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 EFC50763.1 - 1.7e-60 203.9 0.0 2.6e-60 203.3 0.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III_C PF08541.10 EFC50763.1 - 0.12 12.6 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DHHC PF01529.20 EFC50764.1 - 2.5e-33 115.0 11.4 2.5e-33 115.0 11.4 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase rRNA_processing PF08524.11 EFC50765.1 - 2.3e-10 40.7 38.4 2.7e-10 40.4 38.4 1.1 1 0 0 1 1 1 1 rRNA processing CobT PF06213.12 EFC50765.1 - 0.27 10.6 11.8 0.33 10.3 11.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 EFC50765.1 - 5.1 4.9 13.8 6 4.6 13.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RR_TM4-6 PF06459.12 EFC50765.1 - 5.6 6.7 22.0 8.6 6.1 22.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Silic_transp PF03842.13 EFC50765.1 - 8.2 4.6 6.9 9.6 4.4 6.9 1.1 1 0 0 1 1 1 0 Silicon transporter TFA2_Winged_2 PF18121.1 EFC50766.1 - 0.038 13.7 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 TFA2 Winged helix domain 2 Pet191_N PF10203.9 EFC50766.1 - 0.049 13.9 4.3 3.2 8.1 0.3 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 EFC50766.1 - 0.05 13.6 3.8 0.11 12.6 3.8 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Las1 PF04031.13 EFC50767.1 - 1.6e-28 99.7 2.8 2.3e-27 96.0 0.7 2.4 2 1 0 2 2 2 2 Las1-like RNA_pol_Rpb1_2 PF00623.20 EFC50767.1 - 0.059 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 2 efThoc1 PF11957.8 EFC50768.1 - 2.5e-24 85.8 19.7 2.5e-24 85.8 19.7 2.4 2 1 0 2 2 2 1 THO complex subunit 1 transcription elongation factor Peptidase_S24 PF00717.23 EFC50770.1 - 1.8e-11 43.9 0.0 2.9e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase S24-like Abhydrolase_3 PF07859.13 EFC50771.1 - 1.2e-14 54.7 0.0 4.6e-14 52.8 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 EFC50771.1 - 1.4e-11 43.9 1.6 3.7e-11 42.5 0.6 2.0 1 1 1 2 2 2 1 Steryl acetyl hydrolase LIDHydrolase PF10230.9 EFC50771.1 - 6.6e-05 22.6 0.1 0.00046 19.8 0.0 1.9 1 1 1 2 2 2 1 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 EFC50771.1 - 0.00011 21.8 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF3089 PF11288.8 EFC50771.1 - 0.0079 15.8 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Hydrolase_4 PF12146.8 EFC50771.1 - 0.011 15.0 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 BAAT_C PF08840.11 EFC50771.1 - 0.045 13.7 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal NIF PF03031.18 EFC50772.1 - 4.3e-25 88.3 0.9 9.9e-25 87.1 0.9 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 EFC50772.1 - 6.4e-07 29.2 0.1 1.3e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 EFC50772.1 - 2e-06 28.1 0.3 6.4e-06 26.5 0.1 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 EFC50772.1 - 0.0068 16.3 0.1 0.019 14.9 0.1 1.7 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 EFC50772.1 - 0.093 13.0 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain BCIP PF13862.6 EFC50773.1 - 2.8e-47 161.2 1.0 2.8e-47 161.2 1.0 1.4 2 0 0 2 2 2 1 p21-C-terminal region-binding protein RAP-1 PF03085.15 EFC50773.1 - 0.016 15.0 0.6 0.2 11.3 0.4 2.1 2 0 0 2 2 2 0 Rhoptry-associated protein 1 (RAP-1) DUF4464 PF14713.6 EFC50775.1 - 3.7e-87 291.6 9.8 4.9e-87 291.2 9.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4464) NAD_binding_4 PF07993.12 EFC50776.1 - 1.2e-52 178.6 0.0 2.1e-52 177.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Acyltransferase PF01553.21 EFC50776.1 - 1.1e-20 73.6 0.0 2.6e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Sterile PF03015.19 EFC50776.1 - 1.2e-17 63.9 1.2 3.6e-17 62.4 1.2 1.9 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 EFC50776.1 - 0.0016 17.9 0.1 0.02 14.4 0.1 2.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family zf-CpG_bind_C PF12269.8 EFC50776.1 - 0.024 14.4 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain 3Beta_HSD PF01073.19 EFC50776.1 - 0.053 12.5 0.1 5.4 5.9 0.1 3.4 3 1 0 3 3 3 0 3-beta hydroxysteroid dehydrogenase/isomerase family SurA_N_2 PF13623.6 EFC50776.1 - 0.17 11.7 2.8 0.97 9.3 0.6 2.5 2 0 0 2 2 2 0 SurA N-terminal domain AAA PF00004.29 EFC50777.1 - 3.7e-47 160.1 0.0 6.5e-47 159.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 EFC50777.1 - 1.1e-08 35.6 0.2 0.00025 21.5 0.0 3.2 2 1 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 EFC50777.1 - 2.5e-07 30.9 0.0 0.00019 21.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 EFC50777.1 - 1.5e-06 28.0 0.0 3.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 EFC50777.1 - 2.8e-05 24.1 0.2 0.00096 19.2 0.0 3.4 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 EFC50777.1 - 3.9e-05 23.9 0.3 0.0082 16.4 0.1 2.4 1 1 1 2 2 2 1 AAA domain Vps4_C PF09336.10 EFC50777.1 - 5e-05 23.2 0.0 0.00015 21.7 0.0 1.8 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 EFC50777.1 - 0.00029 20.6 0.0 0.00046 20.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 EFC50777.1 - 0.00069 20.0 0.1 0.0066 16.8 0.0 2.4 3 0 0 3 3 2 1 RNA helicase DUF815 PF05673.13 EFC50777.1 - 0.0012 18.1 0.0 0.0024 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 EFC50777.1 - 0.0029 17.8 0.0 0.0057 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 EFC50777.1 - 0.0035 16.8 0.1 0.0099 15.3 0.1 1.6 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 EFC50777.1 - 0.004 17.2 0.0 0.0064 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 EFC50777.1 - 0.0042 17.1 0.0 0.0076 16.3 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 EFC50777.1 - 0.0049 16.8 0.0 0.062 13.2 0.0 2.4 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_lid_3 PF17862.1 EFC50777.1 - 0.0074 16.1 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain NACHT PF05729.12 EFC50777.1 - 0.0076 16.2 0.0 0.086 12.8 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 EFC50777.1 - 0.0087 16.6 0.0 0.019 15.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 EFC50777.1 - 0.011 14.9 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain TIP49 PF06068.13 EFC50777.1 - 0.014 14.6 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 EFC50777.1 - 0.015 14.8 0.0 0.048 13.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 EFC50777.1 - 0.023 14.4 0.0 0.11 12.3 0.0 2.2 2 1 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 EFC50777.1 - 0.025 15.1 0.0 0.049 14.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 EFC50777.1 - 0.026 14.1 0.2 0.096 12.3 0.2 1.9 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 EFC50777.1 - 0.033 13.9 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Parvo_NS1 PF01057.17 EFC50777.1 - 0.035 13.2 0.0 0.066 12.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 EFC50777.1 - 0.04 13.4 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 EFC50777.1 - 0.04 14.2 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 EFC50777.1 - 0.048 13.6 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_3 PF07726.11 EFC50777.1 - 0.07 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 EFC50777.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.6 EFC50777.1 - 0.12 12.1 0.0 0.32 10.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain Zeta_toxin PF06414.12 EFC50777.1 - 0.14 11.4 0.1 0.35 10.1 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_17 PF13207.6 EFC50777.1 - 0.16 12.4 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zn_clus PF00172.18 EFC50778.1 - 8.6e-08 32.2 14.4 8.6e-08 32.2 14.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNAP PF14938.6 EFC50779.1 - 1.3e-21 77.3 9.7 1.8e-21 76.8 9.7 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 EFC50779.1 - 3.5e-09 36.8 0.3 0.0013 19.0 0.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 EFC50779.1 - 7e-06 25.7 0.6 6.4 7.1 0.0 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 EFC50779.1 - 1.6e-05 24.5 9.4 2.5 8.0 0.0 6.1 4 1 2 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 EFC50779.1 - 2.2e-05 24.2 4.8 2.8 8.3 0.0 5.6 4 1 1 6 6 6 1 Tetratricopeptide repeat MIT PF04212.18 EFC50779.1 - 4.5e-05 23.4 4.7 0.0025 17.9 0.1 4.2 3 1 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_8 PF13181.6 EFC50779.1 - 0.00041 20.3 7.5 1.5 9.3 0.0 5.2 5 1 1 6 6 5 1 Tetratricopeptide repeat Clathrin PF00637.20 EFC50779.1 - 0.00066 19.6 2.3 3 7.7 0.0 4.0 2 2 2 4 4 4 1 Region in Clathrin and VPS TPR_14 PF13428.6 EFC50779.1 - 0.05 14.4 0.0 10 7.2 0.0 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat Occludin_ELL PF07303.13 EFC50779.1 - 0.053 14.2 1.1 0.15 12.8 1.1 1.7 1 0 0 1 1 1 0 Occludin homology domain NSF PF02071.20 EFC50779.1 - 0.11 13.3 17.0 54 5.3 0.1 6.6 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat TPR_6 PF13174.6 EFC50779.1 - 0.13 12.9 1.5 36 5.3 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 EFC50779.1 - 0.14 12.8 0.8 2.9 8.6 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 EFC50779.1 - 0.49 10.1 8.5 0.5 10.1 0.0 4.4 4 1 0 4 4 4 0 TPR repeat Ank_2 PF12796.7 EFC50780.1 - 3.3e-20 72.5 0.0 3.7e-10 40.3 0.0 4.9 4 0 0 4 4 4 3 Ankyrin repeats (3 copies) PHD PF00628.29 EFC50780.1 - 3.2e-17 62.1 48.6 1.6e-06 27.9 11.8 4.0 3 0 0 3 3 3 3 PHD-finger Ank_4 PF13637.6 EFC50780.1 - 3.6e-16 59.3 3.8 7.7e-06 26.4 0.2 6.3 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 EFC50780.1 - 8e-16 56.5 3.5 9.5e-05 22.5 0.1 7.0 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 EFC50780.1 - 2.4e-12 46.7 6.0 2.6e-05 24.5 0.0 7.0 7 0 0 7 7 7 2 Ankyrin repeat Ank_5 PF13857.6 EFC50780.1 - 2.2e-10 40.5 0.3 0.00077 19.7 0.0 5.7 5 1 1 7 7 7 3 Ankyrin repeats (many copies) HSP20 PF00011.21 EFC50780.1 - 0.00034 20.7 0.0 0.0014 18.7 0.0 2.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 EFC50780.1 - 0.00093 18.7 0.0 0.0026 17.3 0.0 1.7 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DNA_pol_A_exo1 PF01612.20 EFC50780.1 - 0.022 14.5 0.0 0.074 12.7 0.0 1.9 1 0 0 1 1 1 0 3'-5' exonuclease PHD_2 PF13831.6 EFC50780.1 - 0.027 14.0 35.9 0.027 14.0 5.3 3.7 3 0 0 3 3 3 0 PHD-finger SAGA-Tad1 PF12767.7 EFC50781.1 - 6.9e-20 71.8 3.2 4.3e-12 46.3 0.9 2.2 1 1 1 2 2 2 2 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 EFC50781.1 - 0.00018 21.4 0.0 0.00027 20.8 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family V1R PF03402.14 EFC50781.1 - 0.039 13.6 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 Vomeronasal organ pheromone receptor family, V1R MPM1 PF17234.2 EFC50781.1 - 0.17 12.1 0.0 0.17 12.1 0.0 2.1 2 1 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 IF3_C PF00707.22 EFC50782.1 - 2.2e-11 43.6 4.0 2.2e-11 43.6 4.0 2.2 1 1 1 2 2 2 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 EFC50782.1 - 2.6e-06 27.6 0.0 1e-05 25.7 0.0 2.0 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain Spermine_synth PF01564.17 EFC50783.1 - 1.2e-62 210.7 0.1 3.4e-62 209.2 0.1 1.6 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 EFC50783.1 - 1.5e-22 79.2 0.1 2.8e-22 78.3 0.1 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 EFC50783.1 - 0.018 15.8 0.0 0.034 14.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_30 PF05430.11 EFC50783.1 - 0.065 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 EFC50783.1 - 0.11 13.2 0.0 0.28 11.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain ABC_tran PF00005.27 EFC50784.1 - 4e-43 147.2 0.1 1.3e-20 74.3 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 EFC50784.1 - 8.1e-21 73.9 6.6 8.1e-21 73.9 6.6 3.0 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 EFC50784.1 - 1.6e-18 67.5 7.2 2.7e-05 24.1 0.0 4.4 2 2 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 EFC50784.1 - 8.9e-09 35.1 2.2 0.095 12.1 0.8 4.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 EFC50784.1 - 9.4e-08 31.7 0.3 0.0071 16.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 EFC50784.1 - 7.8e-07 29.3 0.2 0.055 13.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 EFC50784.1 - 1.4e-06 28.9 0.0 0.062 13.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 EFC50784.1 - 1.5e-05 25.3 0.0 0.022 15.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 EFC50784.1 - 2.4e-05 24.9 11.4 0.12 12.9 0.0 4.5 5 0 0 5 5 4 2 AAA domain AAA_15 PF13175.6 EFC50784.1 - 3.6e-05 23.7 5.8 0.12 12.0 0.1 3.9 2 2 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 EFC50784.1 - 5.2e-05 23.3 0.6 0.056 13.5 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 EFC50784.1 - 8.8e-05 22.9 0.0 0.21 12.0 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain NACHT PF05729.12 EFC50784.1 - 0.0001 22.3 0.0 0.64 9.9 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_14 PF13173.6 EFC50784.1 - 0.00011 22.2 0.1 1.2 9.1 0.0 3.7 4 0 0 4 4 3 2 AAA domain AAA_24 PF13479.6 EFC50784.1 - 0.00012 21.8 0.0 0.25 11.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 EFC50784.1 - 0.00013 22.3 0.0 0.15 12.5 0.0 2.9 2 0 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 EFC50784.1 - 0.00016 21.6 2.6 0.11 12.4 0.0 3.3 3 0 0 3 3 3 1 RsgA GTPase AAA PF00004.29 EFC50784.1 - 0.0002 21.8 0.0 0.37 11.2 0.0 3.4 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 EFC50784.1 - 0.00032 20.3 0.7 0.14 11.6 0.0 2.7 3 0 0 3 3 2 1 P-loop containing dynein motor region AAA_28 PF13521.6 EFC50784.1 - 0.0013 19.0 0.0 1.6 9.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_30 PF13604.6 EFC50784.1 - 0.0021 17.8 0.1 0.86 9.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain ATPase_2 PF01637.18 EFC50784.1 - 0.0035 17.3 0.4 3.7 7.4 0.0 3.2 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea MeaB PF03308.16 EFC50784.1 - 0.0068 15.4 2.3 0.57 9.1 0.0 2.8 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 EFC50784.1 - 0.0089 15.2 2.5 0.099 11.8 0.0 2.7 3 0 0 3 3 3 1 NB-ARC domain Arf PF00025.21 EFC50784.1 - 0.014 14.9 0.2 6.9 6.1 0.0 2.7 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_17 PF13207.6 EFC50784.1 - 0.017 15.6 1.0 5.6 7.4 0.0 3.0 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 EFC50784.1 - 0.017 15.1 0.1 0.28 11.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 EFC50784.1 - 0.018 15.2 7.3 0.34 10.9 0.0 3.4 3 1 0 3 3 3 0 Helicase HerA, central domain AAA_5 PF07728.14 EFC50784.1 - 0.021 14.8 0.4 4.7 7.2 0.0 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Ploopntkinase3 PF18751.1 EFC50784.1 - 0.035 14.0 0.1 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AFG1_ATPase PF03969.16 EFC50784.1 - 0.043 12.7 0.2 0.11 11.4 0.0 1.7 2 0 0 2 2 1 0 AFG1-like ATPase AAA_25 PF13481.6 EFC50784.1 - 0.045 13.3 0.0 4.5 6.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 EFC50784.1 - 0.052 13.2 0.1 4.7 6.8 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Cytidylate_kin PF02224.18 EFC50784.1 - 0.062 13.0 0.1 0.81 9.4 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AAA_10 PF12846.7 EFC50784.1 - 0.071 12.0 0.5 0.43 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA-like domain cobW PF02492.19 EFC50784.1 - 0.071 12.7 1.0 5.6 6.5 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 EFC50784.1 - 0.073 12.3 0.1 2.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Roc PF08477.13 EFC50784.1 - 0.081 13.2 0.3 4 7.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Thymidylate_kin PF02223.17 EFC50784.1 - 0.085 12.5 2.7 7.8 6.1 0.0 3.0 3 0 0 3 3 2 0 Thymidylate kinase MukB PF04310.12 EFC50784.1 - 0.098 12.5 2.9 0.9 9.3 0.0 3.0 3 1 0 3 3 3 0 MukB N-terminal AAA_27 PF13514.6 EFC50784.1 - 0.1 12.1 0.0 2.7 7.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 EFC50784.1 - 0.11 12.4 0.0 9.7 6.1 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase ATP_bind_1 PF03029.17 EFC50784.1 - 0.12 12.1 1.8 5.6 6.7 0.0 2.7 3 1 0 3 3 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 EFC50784.1 - 7.5 6.6 8.3 14 5.7 0.0 3.7 3 1 0 3 3 2 0 Dynamin family Stealth_CR2 PF11380.8 EFC50785.1 - 9.5e-45 151.2 0.1 9.5e-45 151.2 0.1 4.1 4 0 0 4 4 4 1 Stealth protein CR2, conserved region 2 Stealth_CR4 PF17103.5 EFC50785.1 - 5.5e-21 74.2 5.3 1.9e-20 72.5 3.8 2.6 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 EFC50785.1 - 2.1e-17 62.8 5.1 2.1e-17 62.8 5.1 1.9 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Notch PF00066.17 EFC50785.1 - 1.4e-13 51.0 30.9 8.5e-08 32.5 10.3 2.3 2 0 0 2 2 2 2 LNR domain Stealth_CR1 PF17101.5 EFC50785.1 - 1.1e-08 34.6 0.0 2.4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Shisa PF13908.6 EFC50785.1 - 0.0046 17.2 0.2 0.0046 17.2 0.2 5.8 4 2 1 6 6 6 1 Wnt and FGF inhibitory regulator Rpn3_C PF08375.11 EFC50785.1 - 1.1 9.7 5.8 0.33 11.4 0.6 3.0 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal Ole-e-6 PF09253.10 EFC50785.1 - 8 6.5 19.0 3.2 7.8 4.0 2.9 2 1 0 2 2 2 0 Pollen allergen ole e 6 CEP19 PF14933.6 EFC50786.1 - 1e-53 182.0 8.4 1.2e-53 181.8 8.4 1.0 1 0 0 1 1 1 1 CEP19-like protein RPN6_N PF18055.1 EFC50786.1 - 0.073 13.4 0.5 0.2 12.0 0.1 1.9 1 1 1 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain FAM176 PF14851.6 EFC50786.1 - 0.31 10.7 6.0 9.9 5.8 3.4 2.1 2 0 0 2 2 2 0 FAM176 family Rsm22 PF09243.10 EFC50787.1 - 3.8e-69 233.0 0.1 1.5e-68 231.1 0.0 2.1 2 1 0 2 2 2 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_12 PF08242.12 EFC50787.1 - 2.8e-06 28.0 0.0 3.5e-05 24.5 0.0 3.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 EFC50787.1 - 4.5e-06 27.3 0.0 1.3e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 EFC50787.1 - 4.7e-06 26.5 0.0 1.2e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain EF-hand_1 PF00036.32 EFC50789.1 - 9.5e-40 131.2 15.1 1.1e-09 37.1 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 EFC50789.1 - 3.4e-33 113.9 4.6 1.8e-16 60.3 1.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 EFC50789.1 - 3.7e-29 100.3 14.3 2e-13 49.9 0.8 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 EFC50789.1 - 8.3e-29 97.0 9.8 1.7e-09 36.9 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 EFC50789.1 - 1.5e-25 87.5 10.4 2.3e-07 30.0 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 EFC50789.1 - 1.6e-14 53.9 0.5 6.2e-09 36.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 EFC50789.1 - 1.1e-08 35.0 2.5 0.00093 19.1 0.5 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 EFC50789.1 - 1.1e-08 35.4 0.5 0.0033 17.7 0.4 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 EFC50789.1 - 4.7e-05 23.5 3.3 0.32 11.2 0.2 3.1 1 1 2 3 3 3 2 Dockerin type I domain UPF0154 PF03672.13 EFC50789.1 - 5.4e-05 23.1 2.6 0.1 12.7 0.0 3.9 4 1 1 5 5 5 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 EFC50789.1 - 9.5e-05 23.2 0.1 0.026 15.4 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain DUF5580 PF17743.1 EFC50789.1 - 0.00069 18.3 0.0 0.00069 18.3 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Caleosin PF05042.13 EFC50789.1 - 0.0012 18.8 2.7 0.37 10.7 1.0 3.5 1 1 2 3 3 3 1 Caleosin related protein TerB PF05099.13 EFC50789.1 - 0.0014 18.6 0.5 0.21 11.6 0.1 2.4 1 1 1 2 2 2 1 Tellurite resistance protein TerB EFhand_Ca_insen PF08726.10 EFC50789.1 - 0.0016 18.5 1.6 0.0059 16.7 0.3 2.4 2 2 0 2 2 2 1 Ca2+ insensitive EF hand DUF4497 PF14924.6 EFC50789.1 - 0.002 18.6 0.1 1.7 9.2 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF4497) DUF3349 PF11829.8 EFC50789.1 - 0.002 18.8 0.5 3 8.7 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Spore_III_AB PF09548.10 EFC50789.1 - 0.011 15.9 0.9 0.027 14.6 0.7 1.7 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) RNA_pol_Rpb4 PF03874.16 EFC50789.1 - 0.016 15.5 1.3 6.9 7.0 0.1 3.1 2 1 1 3 3 3 0 RNA polymerase Rpb4 DUF1103 PF06513.11 EFC50789.1 - 0.023 14.3 6.2 0.025 14.2 5.9 1.3 1 1 0 1 1 1 0 Repeat of unknown function (DUF1103) TetR_C_7 PF14246.6 EFC50789.1 - 0.045 13.8 0.0 7 6.7 0.0 2.8 2 1 1 3 3 3 0 AefR-like transcriptional repressor, C-terminal domain MotA_activ PF09114.10 EFC50789.1 - 0.062 13.4 0.4 1.5 9.0 0.1 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain EF-hand_14 PF17959.1 EFC50789.1 - 0.067 13.6 0.3 11 6.5 0.0 2.5 1 1 1 2 2 2 0 EF-hand domain GPHH PF16905.5 EFC50789.1 - 0.13 12.0 0.0 14 5.5 0.0 3.1 4 0 0 4 4 3 0 Voltage-dependent L-type calcium channel, IQ-associated SapB_1 PF05184.15 EFC50789.1 - 0.54 10.3 7.1 8.4 6.5 0.5 3.5 4 0 0 4 4 3 0 Saposin-like type B, region 1 ANAPC4_WD40 PF12894.7 EFC50790.1 - 3.9e-05 23.9 0.4 0.0067 16.7 0.0 3.6 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 EFC50790.1 - 8.5e-05 23.3 0.0 0.031 15.1 0.0 3.1 2 0 0 2 2 2 1 WD domain, G-beta repeat Utp8 PF10395.9 EFC50790.1 - 0.00085 18.0 3.0 0.0013 17.3 3.0 1.4 1 0 0 1 1 1 1 Utp8 family CAP_assoc_N PF14504.6 EFC50790.1 - 0.0012 18.7 2.0 0.018 14.8 0.3 3.3 2 1 2 4 4 4 1 CAP-associated N-terminal MCU PF04678.13 EFC50791.1 - 0.022 14.9 0.0 0.025 14.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF1672 PF07901.11 EFC50791.1 - 0.033 13.5 2.0 0.041 13.2 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Phage_pRha PF09669.10 EFC50791.1 - 0.035 14.6 1.0 0.051 14.1 1.0 1.3 1 1 0 1 1 1 0 Phage regulatory protein Rha (Phage_pRha) DUF4519 PF15012.6 EFC50791.1 - 9.9 6.4 11.0 1.8 8.8 1.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4519) Pkinase PF00069.25 EFC50792.1 - 2.1e-60 204.3 0.0 2.8e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50792.1 - 2.5e-28 99.1 0.0 4.3e-28 98.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 EFC50792.1 - 1e-05 25.0 0.0 2.2e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 EFC50792.1 - 7.7e-05 21.8 0.1 0.00013 21.0 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 EFC50792.1 - 0.0098 15.2 0.0 0.021 14.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 EFC50792.1 - 0.014 15.0 1.5 0.018 14.7 0.2 1.8 2 0 0 2 2 2 0 RIO1 family MuF_C PF18819.1 EFC50792.1 - 0.066 13.2 0.3 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Phage MuF-C-terminal domain Glyoxalase_2 PF12681.7 EFC50792.1 - 0.54 10.2 6.6 1.7 8.6 0.6 3.0 2 1 1 3 3 3 0 Glyoxalase-like domain HAD PF12710.7 EFC50793.1 - 9.4e-07 29.4 0.0 0.013 15.9 0.0 2.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 EFC50793.1 - 0.00047 19.7 1.6 0.45 10.0 0.0 2.3 2 0 0 2 2 2 2 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 EFC50793.1 - 0.00089 18.7 3.9 0.39 10.1 0.9 3.1 2 1 0 2 2 2 2 Putative Phosphatase HAD_2 PF13419.6 EFC50793.1 - 0.0064 16.6 3.1 0.99 9.5 2.3 2.6 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase eIF-5_eIF-2B PF01873.17 EFC50794.1 - 8.7e-36 122.4 0.1 1.1e-35 122.1 0.1 1.1 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Cys_rich_KTR PF14205.6 EFC50794.1 - 0.049 13.4 0.5 0.19 11.5 0.3 1.9 2 0 0 2 2 2 0 Cysteine-rich KTR Elf1 PF05129.13 EFC50794.1 - 0.064 13.3 0.6 0.064 13.3 0.6 1.6 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Peptidase_M16_C PF05193.21 EFC50794.1 - 0.1 12.6 0.0 0.16 11.9 0.0 1.4 1 1 0 1 1 1 0 Peptidase M16 inactive domain DUF572 PF04502.13 EFC50795.1 - 1.2e-59 202.6 13.3 1.5e-59 202.3 13.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2059 PF09832.9 EFC50795.1 - 0.069 13.2 0.6 0.16 12.0 0.6 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) RasGAP_C PF03836.15 EFC50795.1 - 0.17 12.0 12.2 0.26 11.4 12.2 1.2 1 0 0 1 1 1 0 RasGAP C-terminus DUF2951 PF11166.8 EFC50795.1 - 8.2 6.7 10.9 15 5.9 10.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) Profilin PF00235.19 EFC50796.1 - 1.4e-21 77.1 0.0 1.7e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 Profilin RhoGAP PF00620.27 EFC50797.1 - 1.3e-22 80.3 2.0 3.9e-22 78.7 2.0 1.8 1 0 0 1 1 1 1 RhoGAP domain TPR_MLP1_2 PF07926.12 EFC50797.1 - 0.0045 17.0 12.1 0.0045 17.0 12.1 3.0 3 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein Cas_APE2256 PF09651.10 EFC50797.1 - 0.014 15.3 0.7 0.044 13.7 0.1 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_APE2256) CoA_binding_3 PF13727.6 EFC50797.1 - 0.19 11.8 0.0 0.33 11.0 0.0 1.3 1 0 0 1 1 1 0 CoA-binding domain KfrA_N PF11740.8 EFC50797.1 - 0.26 12.0 7.2 0.056 14.1 3.0 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term DUF5347 PF17282.2 EFC50797.1 - 0.41 11.0 6.7 1.4 9.2 0.0 3.3 3 1 0 3 3 3 0 Family of unknown function (DUF5347) MbeD_MobD PF04899.12 EFC50797.1 - 0.5 10.5 8.5 4 7.6 7.1 3.0 2 0 0 2 2 2 0 MbeD/MobD like Octopine_DH PF02317.17 EFC50797.1 - 0.5 10.4 3.1 0.56 10.3 0.1 2.5 3 1 0 3 3 3 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain DUF4407 PF14362.6 EFC50797.1 - 0.67 9.2 13.2 1.3 8.3 13.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PilJ PF13675.6 EFC50797.1 - 1.5 8.9 6.4 9.7 6.2 0.8 2.8 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term IMUP PF15761.5 EFC50797.1 - 4 8.2 10.3 0.56 10.9 4.6 2.5 2 1 0 2 2 2 0 Immortalisation up-regulated protein Ras PF00071.22 EFC50798.1 - 3.1e-53 179.7 0.0 3.6e-53 179.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50798.1 - 7.1e-24 84.3 0.0 9.6e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50798.1 - 2.5e-09 36.8 0.0 3e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 EFC50798.1 - 0.012 15.0 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 EFC50798.1 - 0.015 14.9 0.1 0.028 14.0 0.0 1.4 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 EFC50798.1 - 0.16 11.4 0.0 0.35 10.4 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region ERG4_ERG24 PF01222.17 EFC50799.1 - 4e-113 378.4 23.0 5.4e-113 378.0 23.0 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Wzy_C_2 PF11846.8 EFC50799.1 - 0.26 11.2 0.1 0.26 11.2 0.1 2.6 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal AAA_22 PF13401.6 EFC50800.1 - 3.7e-06 27.2 0.3 4.8e-05 23.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 EFC50800.1 - 0.00036 20.5 0.2 0.0009 19.2 0.2 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFC50800.1 - 0.00039 20.9 0.0 0.0019 18.6 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 EFC50800.1 - 0.005 16.1 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_11 PF13086.6 EFC50800.1 - 0.027 14.3 0.0 0.82 9.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain Seryl_tRNA_N PF02403.22 EFC50800.1 - 0.034 14.4 0.1 0.29 11.4 0.0 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TolA_bind_tri PF16331.5 EFC50800.1 - 0.37 10.9 3.4 0.25 11.4 0.6 2.1 2 0 0 2 2 2 0 TolA binding protein trimerisation Dynamin_N PF00350.23 EFC50801.1 - 2.6e-34 118.7 0.0 2.6e-34 118.7 0.0 3.0 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 EFC50801.1 - 3.1e-05 24.0 0.0 0.00018 21.6 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase cpYpsA PF12694.7 EFC50801.1 - 0.1 12.4 0.0 0.34 10.7 0.0 1.9 2 0 0 2 2 2 0 Circularly permutated YpsA SLOG family ATPase_2 PF01637.18 EFC50802.1 - 2.1e-07 31.1 1.9 3.9e-05 23.7 0.5 2.7 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea AAA_16 PF13191.6 EFC50802.1 - 4.2e-06 27.2 0.0 8.4e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 EFC50802.1 - 0.0026 17.7 0.1 0.0092 15.9 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain AFG1_ATPase PF03969.16 EFC50802.1 - 0.011 14.7 0.0 0.02 13.8 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase AAA_7 PF12775.7 EFC50802.1 - 0.012 15.1 0.0 0.029 13.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 EFC50802.1 - 0.026 13.7 0.0 0.089 12.0 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain ResIII PF04851.15 EFC50802.1 - 0.033 14.2 0.2 0.033 14.2 0.2 2.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA PF00004.29 EFC50802.1 - 0.037 14.5 0.8 0.3 11.5 0.1 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 EFC50802.1 - 0.048 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 EFC50802.1 - 0.055 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 EFC50802.1 - 0.065 13.3 2.9 0.12 12.5 0.3 2.8 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 EFC50802.1 - 0.1 12.9 0.0 0.53 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF3361 PF11841.8 EFC50802.1 - 1.3 8.9 6.6 16 5.4 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) GCP_C_terminal PF04130.13 EFC50803.1 - 6e-41 140.9 10.4 6e-41 140.9 10.4 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 EFC50803.1 - 4.4e-40 138.2 2.7 7.4e-40 137.5 2.7 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Ycf15 PF10705.9 EFC50803.1 - 0.038 14.2 0.4 0.16 12.1 0.1 2.1 2 0 0 2 2 2 0 Chloroplast protein precursor Ycf15 putative 7TM_GPCR_Sri PF10327.9 EFC50804.1 - 0.053 12.7 1.0 0.1 11.8 0.1 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sri COPIIcoated_ERV PF07970.12 EFC50805.1 - 6.2e-60 202.8 0.7 6.2e-60 202.8 0.7 1.7 2 0 0 2 2 2 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 EFC50805.1 - 9.5e-22 77.2 0.3 1.8e-21 76.3 0.3 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) NDUFB10 PF10249.9 EFC50806.1 - 0.039 14.4 1.6 0.055 14.0 0.7 1.7 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase subunit 10 KRTDAP PF15200.6 EFC50806.1 - 0.097 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Keratinocyte differentiation-associated Clat_adaptor_s PF01217.20 EFC50807.1 - 2.9e-45 153.7 5.1 3.2e-45 153.6 5.1 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Pkinase PF00069.25 EFC50808.1 - 1.2e-42 146.2 0.3 6.9e-42 143.6 0.3 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50808.1 - 3.9e-12 46.0 0.2 2.5e-11 43.4 0.1 2.3 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC50808.1 - 3.6e-05 22.7 0.0 5e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase HTH_52 PF18576.1 EFC50810.1 - 0.022 15.0 0.1 0.089 13.0 0.1 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4635 PF15466.6 EFC50811.1 - 0.081 12.4 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Acetyltransf_7 PF13508.7 EFC50812.1 - 0.0098 16.3 0.1 0.026 15.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 EFC50812.1 - 0.015 15.5 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DSPc PF00782.20 EFC50813.1 - 4.4e-33 113.9 0.2 7e-33 113.3 0.2 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 EFC50813.1 - 2.9e-06 27.7 0.0 0.00086 19.8 0.0 2.7 2 1 1 3 3 3 2 Rhodanese-like domain Y_phosphatase PF00102.27 EFC50813.1 - 5.6e-05 22.8 0.0 8.9e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 EFC50813.1 - 0.008 15.9 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Init_tRNA_PT PF04179.12 EFC50813.1 - 0.015 15.5 0.1 0.029 14.7 0.1 1.4 1 0 0 1 1 1 0 Rit1 DUSP-like domain Arm PF00514.23 EFC50814.1 - 4.7e-11 42.3 9.0 0.00038 20.4 0.0 6.7 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 EFC50814.1 - 6.7e-07 29.6 0.1 0.77 10.2 0.0 5.2 4 1 1 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 EFC50814.1 - 0.00074 20.0 3.8 0.057 13.9 0.1 4.3 3 1 1 4 4 4 2 HEAT-like repeat Arm_2 PF04826.13 EFC50814.1 - 0.0044 16.5 8.1 0.018 14.5 0.2 4.1 4 1 0 4 4 4 2 Armadillo-like HEAT PF02985.22 EFC50814.1 - 0.037 14.3 3.6 60 4.3 0.0 5.0 5 0 0 5 5 5 0 HEAT repeat RRM_1 PF00076.22 EFC50815.1 - 1.5e-18 66.3 1.5 1.5e-06 27.9 0.0 5.1 5 0 0 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 EFC50815.1 - 0.0047 16.7 0.0 1.5 8.7 0.0 2.8 2 0 0 2 2 2 1 Occluded RNA-recognition motif BRAP2 PF07576.12 EFC50815.1 - 0.0061 16.8 0.2 15 5.9 0.0 4.1 5 0 0 5 5 5 1 BRCA1-associated protein 2 PC4 PF02229.16 EFC50815.1 - 0.049 13.3 0.1 0.46 10.2 0.0 2.5 3 0 0 3 3 3 0 Transcriptional Coactivator p15 (PC4) SET_assoc PF11767.8 EFC50815.1 - 0.05 13.3 0.1 0.19 11.4 0.1 1.9 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 EFC50815.1 - 0.072 13.2 0.0 1.2 9.3 0.0 2.9 3 1 0 3 3 3 0 RNA recognition motif SHOCT PF09851.9 EFC50815.1 - 0.15 11.8 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Short C-terminal domain WD40 PF00400.32 EFC50816.1 - 1.6e-21 76.2 5.0 0.00026 21.7 0.1 9.0 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 EFC50816.1 - 9.7e-06 25.8 0.0 0.00043 20.5 0.0 3.7 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 EFC50816.1 - 0.024 13.6 0.0 1.6 7.6 0.0 3.3 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein H2TH PF06831.14 EFC50816.1 - 0.07 13.1 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase H2TH domain DUF2781 PF10914.8 EFC50817.1 - 1.4e-20 74.2 6.3 1.4e-20 74.2 6.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2781) DUF5589 PF17672.1 EFC50817.1 - 0.15 12.0 4.4 0.19 11.7 2.3 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5589) Abhydrolase_6 PF12697.7 EFC50818.1 - 1.4e-09 38.9 0.0 1.8e-09 38.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 EFC50818.1 - 4.6e-09 35.9 0.0 6.4e-09 35.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 EFC50818.1 - 5.9e-07 29.4 0.0 1.1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 EFC50818.1 - 9.2e-05 21.8 0.0 0.00017 20.9 0.0 1.4 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase LIDHydrolase PF10230.9 EFC50818.1 - 0.00084 19.0 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase DUF900 PF05990.12 EFC50818.1 - 0.00097 18.7 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 EFC50818.1 - 0.0012 18.6 0.7 0.0045 16.7 0.2 2.2 2 1 0 2 2 2 1 PGAP1-like protein Palm_thioest PF02089.15 EFC50818.1 - 0.0051 16.7 0.0 0.0085 16.0 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF676 PF05057.14 EFC50818.1 - 0.013 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_8 PF06259.12 EFC50818.1 - 0.017 14.8 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Abhydrolase_5 PF12695.7 EFC50818.1 - 0.028 14.2 0.0 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 EFC50818.1 - 0.036 13.9 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 Serine hydrolase DUF915 PF06028.11 EFC50818.1 - 0.052 12.9 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF726 PF05277.12 EFC50818.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF726) CbtA PF09490.10 EFC50818.1 - 0.22 11.3 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) gpUL132 PF11359.8 EFC50820.1 - 0.048 13.2 0.8 0.12 11.9 0.8 1.6 1 0 0 1 1 1 0 Glycoprotein UL132 DUF872 PF05915.12 EFC50820.1 - 1 9.6 7.6 0.12 12.6 0.4 2.5 1 1 2 3 3 3 0 Eukaryotic protein of unknown function (DUF872) DUF1378 PF07125.11 EFC50820.1 - 1.9 8.7 5.9 0.81 9.9 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1378) Tim17 PF02466.19 EFC50821.1 - 1.5e-09 38.2 0.2 1.4e-08 35.0 0.2 2.1 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Peptidase_S9 PF00326.21 EFC50822.1 - 1.4e-31 109.7 0.0 2.3e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 EFC50822.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) PX PF00787.24 EFC50823.1 - 3.7e-16 59.1 4.9 1.9e-15 56.8 0.5 3.3 2 1 1 3 3 3 1 PX domain F-box-like PF12937.7 EFC50823.1 - 9.1e-06 25.5 0.4 9.1e-06 25.5 0.4 2.0 2 0 0 2 2 2 1 F-box-like Pkinase PF00069.25 EFC50824.1 - 5.2e-56 189.9 0.7 2.3e-55 187.8 0.1 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50824.1 - 1.3e-51 175.4 0.1 1.2e-44 152.6 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 EFC50824.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family LapA_dom PF06305.11 EFC50824.1 - 0.14 12.0 0.2 0.27 11.1 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Hydrolase PF00702.26 EFC50825.1 - 2.8e-10 40.8 0.0 3.3e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 EFC50825.1 - 1.9e-05 24.8 0.1 3.6e-05 23.9 0.1 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Rep_fac_C PF08542.11 EFC50825.1 - 0.0079 16.6 0.0 0.017 15.5 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain Hydrolase_like PF13242.6 EFC50825.1 - 0.017 15.2 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like DUF1048 PF06304.11 EFC50825.1 - 0.049 14.1 0.1 0.21 12.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1048) FHIPEP PF00771.20 EFC50825.1 - 0.084 11.3 0.1 0.1 11.0 0.1 1.1 1 0 0 1 1 1 0 FHIPEP family Semialdhyde_dhC PF02774.18 EFC50825.1 - 0.15 12.1 0.1 1.5 8.8 0.1 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain DUF1690 PF07956.11 EFC50826.1 - 0.00053 20.4 2.5 0.00057 20.3 1.7 1.5 1 1 0 1 1 1 1 Protein of Unknown function (DUF1690) TFIIA PF03153.13 EFC50826.1 - 0.34 10.8 10.0 0.36 10.8 10.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit C2-C2_1 PF11618.8 EFC50827.1 - 8.7e-16 58.3 0.1 2.3e-15 56.9 0.1 1.8 1 0 0 1 1 1 1 First C2 domain of RPGR-interacting protein 1 ADIP PF11559.8 EFC50827.1 - 0.0026 17.9 12.3 0.0026 17.9 12.3 3.3 1 1 2 3 3 3 1 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 EFC50827.1 - 0.16 12.2 43.3 0.11 12.7 21.0 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FPP PF05911.11 EFC50827.1 - 0.31 9.2 39.9 7.1 4.7 39.9 2.0 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil Corona_S2 PF01601.16 EFC50827.1 - 4.4 5.7 8.5 1.5 7.2 3.4 2.1 1 1 1 2 2 2 0 Coronavirus S2 glycoprotein Seryl_tRNA_N PF02403.22 EFC50827.1 - 4.6 7.5 33.4 1.6 9.0 7.8 2.9 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Flavokinase PF01687.17 EFC50828.1 - 3.3e-31 107.9 0.0 3.9e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase PCIF1_WW PF12237.8 EFC50829.1 - 1.2e-49 168.2 2.0 3e-49 167.0 2.0 1.6 1 0 0 1 1 1 1 Phosphorylated CTD interacting factor 1 WW domain Gp-FAR-1 PF05823.12 EFC50829.1 - 0.0024 18.2 1.4 0.0066 16.8 1.4 1.8 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Rhomboid PF01694.22 EFC50830.1 - 5.4e-35 120.6 10.9 6.1e-35 120.4 10.9 1.0 1 0 0 1 1 1 1 Rhomboid family SieB PF14163.6 EFC50831.1 - 0.098 12.2 1.5 0.19 11.2 1.5 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B YMF19 PF02326.15 EFC50831.1 - 1.1 10.1 6.0 3.2 8.6 6.0 1.8 1 0 0 1 1 1 0 Plant ATP synthase F0 ELYS PF13934.6 EFC50832.1 - 8.1e-20 71.8 0.4 1.5e-19 70.8 0.4 1.4 1 0 0 1 1 1 1 Nuclear pore complex assembly RAB3GAP2_N PF14655.6 EFC50832.1 - 0.0046 16.3 2.4 0.006 15.9 0.1 2.2 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Arf PF00025.21 EFC50833.1 - 4.7e-51 172.7 0.0 5.7e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 EFC50833.1 - 3e-13 49.7 2.9 1.1e-07 31.3 0.2 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 EFC50833.1 - 8.9e-12 44.8 0.0 1.1e-11 44.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 EFC50833.1 - 3.2e-10 40.3 0.0 4.8e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 EFC50833.1 - 5.3e-10 39.1 0.0 5.8e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 EFC50833.1 - 1.9e-08 34.4 0.0 2.9e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 EFC50833.1 - 1.7e-06 27.7 0.0 3.2e-05 23.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 EFC50833.1 - 6.4e-05 22.4 0.0 7.7e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 EFC50833.1 - 0.00019 21.0 0.2 0.0006 19.4 0.2 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 EFC50833.1 - 0.00022 21.2 0.1 0.069 13.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 EFC50833.1 - 0.0028 18.2 0.0 0.0045 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC50833.1 - 0.011 16.0 0.1 0.083 13.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 EFC50833.1 - 0.11 11.7 0.2 0.52 9.5 0.0 2.1 1 1 1 2 2 2 0 Septin SAM_PNT PF02198.16 EFC50833.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Phos_pyr_kin PF08543.12 EFC50834.1 - 5.6e-16 58.7 0.0 7.6e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 EFC50834.1 - 6.9e-07 28.9 0.0 9e-06 25.2 0.0 2.2 2 1 0 2 2 2 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 EFC50834.1 - 0.0059 16.1 0.0 0.015 14.7 0.0 1.6 1 1 0 1 1 1 1 Carbohydrate kinase NADH_Oxid_Nqo15 PF11497.8 EFC50834.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 TPT PF03151.16 EFC50835.1 - 6.7e-20 71.6 26.2 7.7e-20 71.4 26.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 EFC50835.1 - 6.4e-07 29.6 36.0 1.2e-06 28.7 14.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family TMEM234 PF10639.9 EFC50835.1 - 0.0041 17.1 2.0 0.0041 17.1 2.0 3.5 2 2 2 4 4 4 1 Putative transmembrane family 234 PUNUT PF16913.5 EFC50835.1 - 9.6 5.3 35.0 0.18 11.0 24.2 2.2 1 1 0 2 2 2 0 Purine nucleobase transmembrane transport Rad51 PF08423.11 EFC50836.1 - 2.9e-16 59.5 4.1 2e-15 56.8 4.1 2.0 1 1 0 1 1 1 1 Rad51 DnaB_C PF03796.15 EFC50836.1 - 1.2e-09 37.8 1.2 1.8e-09 37.4 1.2 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain RecA PF00154.21 EFC50836.1 - 5.1e-06 26.2 1.6 9.7e-05 22.0 0.1 2.6 1 1 0 2 2 2 1 recA bacterial DNA recombination protein ATPase PF06745.13 EFC50836.1 - 8.9e-06 25.2 1.5 1.3e-05 24.6 0.4 1.9 2 1 0 2 2 2 1 KaiC DUF4468 PF14730.6 EFC50836.1 - 0.0011 19.2 0.8 0.0031 17.8 0.8 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4468) with TBP-like fold Hydant_A_N PF05378.13 EFC50836.1 - 0.071 12.8 0.3 0.13 12.0 0.3 1.5 1 1 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region ABC_tran PF00005.27 EFC50836.1 - 0.15 12.6 2.9 0.095 13.2 0.5 2.1 2 1 0 2 2 2 0 ABC transporter Rep_fac-A_C PF08646.10 EFC50837.1 - 0.033 13.9 0.2 0.088 12.6 0.2 1.7 1 0 0 1 1 1 0 Replication factor-A C terminal domain zf-ribbon_3 PF13248.6 EFC50837.1 - 0.61 9.6 2.4 4.1 6.9 0.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain TLD PF07534.16 EFC50838.1 - 1.2e-21 77.4 4.6 1.5e-21 77.1 4.6 1.1 1 0 0 1 1 1 1 TLD Pkinase PF00069.25 EFC50839.1 - 2.4e-18 66.5 0.6 1.8e-17 63.6 0.6 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50839.1 - 1.4e-09 37.6 0.1 2.5e-09 36.8 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 EFC50839.1 - 0.001 18.0 0.2 0.0025 16.7 0.2 1.6 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 EFC50839.1 - 0.027 14.1 0.1 0.068 12.8 0.1 1.7 1 0 0 1 1 1 0 RIO1 family AMP-binding PF00501.28 EFC50840.1 - 3.1e-72 243.5 0.0 4.2e-72 243.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 EFC50840.1 - 1.7e-65 220.8 0.0 2.9e-65 220.0 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 EFC50840.1 - 3.9e-12 46.4 0.0 1e-11 45.0 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 EFC50840.1 - 1.8e-11 44.0 0.0 2.5e-10 40.3 0.0 2.7 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 EFC50840.1 - 4.3e-10 39.1 0.3 1.2e-08 34.3 0.1 2.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 EFC50840.1 - 1.6e-07 32.2 0.0 4.5e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 EFC50840.1 - 4.7e-05 23.0 0.2 0.3 10.4 0.0 3.1 2 1 0 3 3 3 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 EFC50840.1 - 0.018 14.2 1.3 1.4 8.0 0.0 3.4 3 1 1 4 4 4 0 Polysaccharide biosynthesis protein AAA_5 PF07728.14 EFC50841.1 - 4.5e-07 29.9 0.0 1.5e-06 28.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 EFC50841.1 - 2.8e-05 24.3 0.0 7.3e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 EFC50841.1 - 0.0012 19.3 0.0 0.0044 17.4 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 EFC50841.1 - 0.02 15.0 0.0 0.051 13.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 EFC50841.1 - 0.039 14.2 0.0 0.13 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Acetyltransf_2 PF00797.17 EFC50842.1 - 0.046 13.5 0.2 0.083 12.7 0.2 1.4 1 0 0 1 1 1 0 N-acetyltransferase Cpn60_TCP1 PF00118.24 EFC50843.1 - 1.4e-68 231.7 0.3 2.6e-67 227.6 0.3 2.1 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family LAGLIDADG_WhiA PF14527.6 EFC50843.1 - 0.038 14.1 1.8 0.45 10.6 0.0 3.2 3 0 0 3 3 3 0 WhiA LAGLIDADG-like domain Actin PF00022.19 EFC50844.1 - 2.9e-99 332.4 0.0 1.3e-98 330.3 0.0 1.7 1 1 0 1 1 1 1 Actin RabGAP-TBC PF00566.18 EFC50845.1 - 3.9e-27 95.3 0.1 3.9e-27 95.3 0.1 2.2 3 0 0 3 3 3 1 Rab-GTPase-TBC domain TLD PF07534.16 EFC50845.1 - 5.2e-25 88.3 0.2 1.7e-21 76.9 0.0 3.2 3 0 0 3 3 3 2 TLD DUF3137 PF11335.8 EFC50845.1 - 0.014 15.3 0.8 0.051 13.5 0.8 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3137) DUF4619 PF15398.6 EFC50845.1 - 0.053 13.0 3.8 0.11 12.0 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4619) Phospholip_A2_1 PF00068.19 EFC50846.1 - 0.0021 18.5 0.0 0.003 18.0 0.0 1.4 1 0 0 1 1 1 1 Phospholipase A2 DUF1869 PF08956.10 EFC50846.1 - 0.0035 17.2 0.0 0.0059 16.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1869) PqqD PF05402.12 EFC50846.1 - 0.052 13.8 0.0 0.084 13.2 0.0 1.3 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) Cas6_N PF17952.1 EFC50846.1 - 0.057 13.7 0.0 0.089 13.1 0.0 1.3 1 0 0 1 1 1 0 Cas6 N-terminal domain Parvo_coat_N PF08398.10 EFC50846.1 - 0.078 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus coat protein VP1 SMODS PF18144.1 EFC50846.1 - 0.14 12.3 0.1 2.4 8.3 0.0 2.0 2 0 0 2 2 2 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain LEA_4 PF02987.16 EFC50847.1 - 1.1e-07 31.8 37.0 0.00017 21.6 14.1 4.1 4 1 0 4 4 4 2 Late embryogenesis abundant protein Apolipoprotein PF01442.18 EFC50847.1 - 1.3e-05 25.2 13.6 2e-05 24.6 13.6 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain YtxH PF12732.7 EFC50847.1 - 5.7e-05 23.6 32.7 0.14 12.7 13.1 3.9 1 1 2 3 3 3 3 YtxH-like protein DUF883 PF05957.13 EFC50847.1 - 0.00018 22.0 17.1 0.018 15.6 8.6 3.0 1 1 2 3 3 3 2 Bacterial protein of unknown function (DUF883) AAA_27 PF13514.6 EFC50847.1 - 0.034 13.7 3.9 0.026 14.1 2.1 1.6 1 1 0 1 1 1 0 AAA domain Prominin PF05478.11 EFC50847.1 - 0.043 11.8 9.7 0.062 11.3 9.7 1.1 1 0 0 1 1 1 0 Prominin ApoLp-III PF07464.11 EFC50847.1 - 0.07 13.2 21.4 0.67 10.0 13.8 2.5 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Tape_meas_lam_C PF09718.10 EFC50847.1 - 0.49 10.6 5.5 3.6 7.8 0.5 2.8 1 1 2 3 3 3 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) Tweety PF04906.13 EFC50847.1 - 0.61 8.7 4.0 1 8.0 4.0 1.4 1 0 0 1 1 1 0 Tweety Phasin PF05597.11 EFC50847.1 - 0.7 9.9 20.3 0.77 9.8 6.7 2.8 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) ATP-synt_B PF00430.18 EFC50847.1 - 0.92 9.6 20.1 1.2 9.3 5.7 2.3 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Herpes_UL6 PF01763.16 EFC50847.1 - 1.6 7.1 11.9 0.14 10.7 7.5 1.4 2 0 0 2 2 2 0 Herpesvirus UL6 like PhaP_Bmeg PF09602.10 EFC50847.1 - 1.9 8.4 16.1 5.1 7.0 6.2 2.3 1 1 1 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) TMP_2 PF06791.13 EFC50847.1 - 2 8.0 12.9 0.72 9.5 3.9 2.1 1 1 0 2 2 2 0 Prophage tail length tape measure protein ApoO PF09769.9 EFC50847.1 - 2.1 8.3 6.0 9 6.3 3.4 3.1 2 1 1 3 3 3 0 Apolipoprotein O Borrelia_P83 PF05262.11 EFC50847.1 - 2.3 6.6 22.5 3.6 6.0 22.5 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein EspB PF05802.11 EFC50847.1 - 3 7.8 24.2 6.1 6.8 15.8 2.6 1 1 1 2 2 2 0 Enterobacterial EspB protein Syntaxin PF00804.25 EFC50847.1 - 4 7.1 19.5 6.4 6.4 19.5 1.3 1 0 0 1 1 1 0 Syntaxin Phasin_2 PF09361.10 EFC50847.1 - 4.6 7.6 13.6 20 5.5 12.2 2.2 1 1 1 2 2 2 0 Phasin protein DUF4777 PF16007.5 EFC50847.1 - 5 7.4 5.9 7.9 6.8 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4777) LMBR1 PF04791.16 EFC50847.1 - 5.7 5.7 8.0 7 5.4 8.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RRM_1 PF00076.22 EFC50848.1 - 2.1e-18 65.9 0.0 4.5e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 EFC50848.1 - 0.014 15.5 0.0 0.061 13.5 0.0 2.1 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM PF05172.13 EFC50848.1 - 0.023 14.6 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif ArfGap PF01412.18 EFC50849.1 - 4.8e-40 136.3 0.1 8.5e-40 135.5 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Drf_FH1 PF06346.12 EFC50849.1 - 2.1 8.1 65.0 0.76 9.5 58.8 2.6 2 1 0 2 2 2 0 Formin Homology Region 1 EVE PF01878.18 EFC50850.1 - 2.6e-17 63.2 0.2 3e-17 63.0 0.2 1.1 1 0 0 1 1 1 1 EVE domain TFIIS_C PF01096.18 EFC50851.1 - 1.5e-15 56.7 2.4 1.5e-15 56.7 2.4 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 EFC50851.1 - 0.00019 21.3 10.9 0.00033 20.5 0.8 2.9 3 0 0 3 3 3 2 RNA polymerases M/15 Kd subunit tRNA-synt_1f PF01921.18 EFC50851.1 - 0.0018 17.3 0.5 0.0047 15.9 0.1 1.7 1 1 1 2 2 2 1 tRNA synthetases class I (K) DUF2387 PF09526.10 EFC50851.1 - 0.0023 18.0 0.2 0.016 15.4 0.1 2.2 1 1 1 2 2 2 1 Probable metal-binding protein (DUF2387) C1_1 PF00130.22 EFC50851.1 - 0.014 15.2 2.2 0.014 15.2 2.2 2.3 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Lar_restr_allev PF14354.6 EFC50851.1 - 0.067 13.6 11.0 0.095 13.1 0.7 3.1 2 1 0 2 2 2 0 Restriction alleviation protein Lar DZR PF12773.7 EFC50851.1 - 0.081 13.0 12.1 35 4.5 12.1 2.9 1 1 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 EFC50851.1 - 0.36 10.8 8.3 0.27 11.2 0.8 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Rpr2 PF04032.16 EFC50851.1 - 0.89 9.9 8.1 68 3.8 8.1 2.9 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Terminase_GpA PF05876.12 EFC50851.1 - 7.8 4.9 6.8 0.52 8.8 0.5 2.0 1 1 2 3 3 3 0 Phage terminase large subunit (GpA) zinc_ribbon_10 PF10058.9 EFC50851.1 - 8.7 6.2 13.3 19 5.1 2.7 3.1 2 2 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Sel1 PF08238.12 EFC50852.1 - 3.1e-37 126.1 11.0 1e-09 38.7 0.1 5.2 5 0 0 5 5 5 4 Sel1 repeat Pkinase PF00069.25 EFC50853.1 - 6.4e-44 150.3 0.7 7.1e-44 150.1 0.7 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50853.1 - 6.3e-30 104.3 0.2 7.1e-30 104.2 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 EFC50853.1 - 1.7e-08 33.8 0.1 2.1e-08 33.5 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 EFC50853.1 - 2.8e-07 29.7 0.0 5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 EFC50853.1 - 0.0025 17.2 0.1 0.003 16.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CbtA_toxin PF06755.12 EFC50853.1 - 0.047 13.7 0.1 0.12 12.4 0.1 1.6 1 1 1 2 2 2 0 CbtA_toxin of type IV toxin-antitoxin system RIO1 PF01163.22 EFC50853.1 - 0.069 12.7 1.5 0.18 11.4 1.5 1.6 1 1 0 1 1 1 0 RIO1 family DUF4116 PF13475.6 EFC50854.1 - 6.3e-14 51.4 0.7 1.3e-10 40.8 0.1 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4116) Plk4_PB1 PF18190.1 EFC50854.1 - 0.032 14.4 0.2 10 6.3 0.1 2.5 3 0 0 3 3 3 0 Polo-like Kinase 4 Polo Box 1 DUF4894 PF16235.5 EFC50854.1 - 0.097 13.0 5.2 0.43 10.9 2.6 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4894) MATH PF00917.26 EFC50855.1 - 0.088 13.0 1.7 0.41 10.8 0.2 2.9 2 0 0 2 2 2 0 MATH domain Asp5 PF17000.5 EFC50856.1 - 0.2 11.8 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Accessory secretory protein Sec, Asp5 EGF_2 PF07974.13 EFC50857.1 - 0.013 15.8 5.3 0.013 15.8 5.3 3.5 4 0 0 4 4 4 0 EGF-like domain Macoilin PF09726.9 EFC50858.1 - 1.6 7.2 49.9 2.1 6.8 49.9 1.3 1 0 0 1 1 1 0 Macoilin family TFIIA PF03153.13 EFC50858.1 - 7.2 6.5 55.7 9.2 6.1 55.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RGS PF00615.19 EFC50859.1 - 9.3e-13 48.5 2.4 1.6e-12 47.7 2.4 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain BRO1 PF03097.18 EFC50860.1 - 1e-20 73.9 1.0 6.4e-20 71.3 1.0 1.8 1 1 0 1 1 1 1 BRO1-like domain SRP14 PF02290.15 EFC50861.1 - 3.1e-19 69.2 4.5 3.1e-19 69.2 4.5 1.9 2 1 0 2 2 2 1 Signal recognition particle 14kD protein DUF2458 PF10454.9 EFC50861.1 - 0.13 11.9 6.5 0.068 12.8 1.8 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2458) Arm PF00514.23 EFC50862.1 - 3.4e-18 65.0 3.0 0.042 13.9 0.0 6.4 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 EFC50862.1 - 1.4e-06 28.4 0.8 0.056 13.7 0.0 3.8 3 1 1 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 Adaptin_N PF01602.20 EFC50862.1 - 0.0019 16.9 0.4 0.012 14.2 0.0 2.3 2 1 0 2 2 2 1 Adaptin N terminal region HEAT_EZ PF13513.6 EFC50862.1 - 0.024 15.2 0.1 4.7 7.8 0.0 3.7 4 0 0 4 4 4 0 HEAT-like repeat RNase_T PF00929.24 EFC50864.1 - 1.4e-19 71.2 0.1 5.1e-19 69.4 0.0 1.9 2 0 0 2 2 2 1 Exonuclease NPM1-C PF16276.5 EFC50864.1 - 0.044 13.8 0.1 0.13 12.2 0.1 1.8 1 0 0 1 1 1 0 Nucleophosmin C-terminal domain MORN PF02493.20 EFC50865.1 - 1.3e-05 24.8 0.7 1.3e-05 24.8 0.7 3.6 4 0 0 4 4 4 1 MORN repeat Glyco_transf_22 PF03901.17 EFC50866.1 - 1.8e-29 103.2 34.2 3e-29 102.5 34.2 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family tRNA-synt_2b PF00587.25 EFC50867.1 - 1.4e-25 90.3 0.0 5e-25 88.5 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 EFC50867.1 - 0.0018 18.5 12.1 0.049 13.9 12.1 2.5 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF406 PF04175.12 EFC50867.1 - 0.027 14.9 0.6 0.069 13.6 0.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF406) MreB_Mbl PF06723.13 EFC50867.1 - 0.18 10.6 0.9 0.29 9.9 0.9 1.2 1 0 0 1 1 1 0 MreB/Mbl protein MMR_HSR1 PF01926.23 EFC50868.1 - 2.8e-19 69.3 2.7 4.8e-19 68.5 0.1 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 EFC50868.1 - 3.3e-09 36.5 0.1 8.3e-09 35.2 0.1 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B Ras PF00071.22 EFC50868.1 - 4.1e-06 26.5 1.9 0.00012 21.7 0.1 3.1 2 2 0 3 3 3 1 Ras family RsgA_GTPase PF03193.16 EFC50868.1 - 5.4e-06 26.4 9.2 5.4e-05 23.2 1.2 3.2 3 1 0 3 3 3 2 RsgA GTPase TniB PF05621.11 EFC50868.1 - 1.8e-05 24.3 0.2 3.6e-05 23.3 0.2 1.5 1 0 0 1 1 1 1 Bacterial TniB protein Arf PF00025.21 EFC50868.1 - 2.9e-05 23.6 1.6 0.00077 19.0 0.0 2.8 2 1 1 3 3 3 1 ADP-ribosylation factor family Roc PF08477.13 EFC50868.1 - 0.00026 21.2 0.0 0.00026 21.2 0.0 2.7 4 0 0 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 EFC50868.1 - 0.001 19.2 1.3 0.001 19.2 1.3 4.3 1 1 1 2 2 1 1 Dynamin family AAA_28 PF13521.6 EFC50868.1 - 0.0048 17.2 0.2 2.1 8.6 0.0 2.8 2 1 1 3 3 3 1 AAA domain XRN_N PF03159.18 EFC50868.1 - 0.0052 16.2 0.5 0.0052 16.2 0.5 2.2 2 2 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus GBP PF02263.19 EFC50868.1 - 0.019 14.2 0.0 0.019 14.2 0.0 2.2 2 0 0 2 2 2 0 Guanylate-binding protein, N-terminal domain GTP_EFTU PF00009.27 EFC50868.1 - 0.019 14.5 6.5 0.047 13.2 0.2 3.3 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 EFC50868.1 - 0.03 14.1 0.1 0.55 10.0 0.1 2.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation LMBR1 PF04791.16 EFC50868.1 - 3.1 6.6 12.7 5.7 5.7 12.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein MORN PF02493.20 EFC50869.1 - 8e-13 47.5 24.6 2.5e-07 30.2 1.1 5.4 5 0 0 5 5 5 3 MORN repeat DUF3986 PF13143.6 EFC50869.1 - 0.022 15.8 0.3 0.022 15.8 0.3 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF3986) ASC PF00858.24 EFC50870.1 - 2.1e-12 46.8 13.3 0.00015 20.9 0.2 3.1 1 1 2 3 3 3 3 Amiloride-sensitive sodium channel ELL PF10390.9 EFC50871.1 - 0.021 14.4 0.2 0.026 14.0 0.2 1.1 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL HycI PF01750.18 EFC50871.1 - 0.04 13.7 0.0 0.062 13.1 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase maturation protease Pkinase PF00069.25 EFC50872.1 - 2.2e-08 33.8 0.2 5.2e-08 32.6 0.2 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50872.1 - 1.4e-06 27.8 0.0 2.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Beta_helix PF13229.6 EFC50872.1 - 1.9e-05 24.6 14.4 1.9e-05 24.6 14.4 1.9 2 0 0 2 2 2 1 Right handed beta helix region FTA2 PF13095.6 EFC50872.1 - 0.082 12.5 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 KIAA1430 PF13879.6 EFC50872.1 - 0.35 11.7 9.1 0.064 14.0 3.6 2.5 1 1 0 2 2 2 0 KIAA1430 homologue Ecl1 PF12855.7 EFC50872.1 - 7.9 7.6 15.7 15 6.7 15.7 1.4 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins ANAPC4_WD40 PF12894.7 EFC50873.1 - 5.6e-06 26.6 0.0 0.00034 20.8 0.0 3.4 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 EFC50873.1 - 0.0014 18.6 0.0 0.027 14.4 0.0 2.7 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 EFC50873.1 - 0.011 16.6 0.2 0.76 10.8 0.0 3.6 4 0 0 4 4 4 0 WD domain, G-beta repeat Barttin PF15462.6 EFC50875.1 - 0.19 11.5 3.2 1.1 9.0 0.1 2.5 2 1 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) DNA_pol_B_palm PF14792.6 EFC50876.1 - 0.072 13.3 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase beta palm Guanylate_cyc PF00211.20 EFC50877.1 - 1.1e-37 129.4 0.3 3e-37 128.0 0.3 1.7 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAS_9 PF13426.7 EFC50877.1 - 2.1e-09 37.5 0.0 1.1e-08 35.3 0.0 2.4 1 0 0 1 1 1 1 PAS domain PAS_8 PF13188.7 EFC50877.1 - 0.0009 19.2 0.0 0.0023 17.9 0.0 1.7 1 0 0 1 1 1 1 PAS domain HNOBA PF07701.14 EFC50877.1 - 0.0091 15.4 0.1 0.031 13.7 0.1 1.9 1 0 0 1 1 1 1 Heme NO binding associated PAS PF00989.25 EFC50877.1 - 0.019 14.9 0.0 0.067 13.2 0.0 2.0 1 0 0 1 1 1 0 PAS fold START PF01852.19 EFC50877.1 - 0.028 13.8 0.1 0.054 12.9 0.1 1.4 1 0 0 1 1 1 0 START domain Ras PF00071.22 EFC50878.1 - 9e-50 168.4 0.0 1.1e-49 168.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 EFC50878.1 - 1.7e-18 66.9 0.0 2.8e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 EFC50878.1 - 6.1e-11 42.1 0.0 9.9e-11 41.4 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 EFC50878.1 - 5.9e-08 32.5 0.1 8.6e-08 32.0 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 EFC50878.1 - 2.3e-06 27.6 0.0 0.00014 21.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase G-alpha PF00503.20 EFC50878.1 - 0.00084 18.6 0.0 0.015 14.5 0.0 2.2 2 1 0 2 2 2 1 G-protein alpha subunit ATP_bind_1 PF03029.17 EFC50878.1 - 0.0096 15.7 0.9 0.016 15.0 0.0 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein cobW PF02492.19 EFC50878.1 - 0.046 13.3 2.9 0.12 12.0 0.0 2.6 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF4604 PF15377.6 EFC50878.1 - 0.078 13.4 4.1 0.17 12.3 4.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4604) MRF_C1 PF13887.6 EFC50879.1 - 0.079 12.1 0.2 0.22 10.7 0.2 1.8 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 Ribosomal_S21e PF01249.18 EFC50880.1 - 0.086 13.0 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S21e Thioredoxin PF00085.20 EFC50881.1 - 2e-26 92.0 0.3 2.2e-26 91.8 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 EFC50881.1 - 4.1e-09 36.6 0.4 9.2e-09 35.5 0.4 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 EFC50881.1 - 7.9e-08 32.7 0.1 6.3e-07 29.8 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 EFC50881.1 - 2.2e-06 27.6 0.1 2.9e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.6 EFC50881.1 - 2.8e-06 27.1 0.1 3.2e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 EFC50881.1 - 1.6e-05 24.9 0.1 1.9e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Redoxin PF08534.10 EFC50881.1 - 8.5e-05 22.3 0.5 0.011 15.4 0.4 2.0 1 1 1 2 2 2 2 Redoxin HyaE PF07449.11 EFC50881.1 - 0.00013 21.9 0.0 0.00015 21.7 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 EFC50881.1 - 0.00078 19.6 0.5 0.0012 19.0 0.5 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_4 PF13462.6 EFC50881.1 - 0.0018 18.5 0.3 0.23 11.6 0.3 2.1 1 1 1 2 2 2 1 Thioredoxin DUF836 PF05768.14 EFC50881.1 - 0.0057 17.0 0.1 0.0081 16.6 0.1 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_3 PF13192.6 EFC50881.1 - 0.0063 16.5 0.1 0.0081 16.2 0.1 1.3 1 0 0 1 1 1 1 Thioredoxin domain OST3_OST6 PF04756.13 EFC50881.1 - 0.0089 15.4 0.2 0.0094 15.3 0.2 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Exo70 PF03081.15 EFC50882.1 - 3.3e-66 223.9 23.3 5.2e-66 223.2 23.3 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Sec34 PF04136.15 EFC50882.1 - 6.6e-06 26.1 0.6 6.6e-06 26.1 0.6 4.5 6 0 0 6 6 6 1 Sec34-like family UME PF08064.13 EFC50882.1 - 0.018 14.9 0.6 10 6.1 0.1 3.6 3 0 0 3 3 3 0 UME (NUC010) domain DUF2870 PF11069.8 EFC50882.1 - 0.064 13.7 3.5 0.078 13.4 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) 7TMR-HDED PF07697.11 EFC50882.1 - 4.4 7.4 14.0 2.3 8.3 8.7 2.8 2 1 0 2 2 2 0 7TM-HD extracellular Pkinase PF00069.25 EFC50884.1 - 1.5e-18 67.1 1.2 5.8e-18 65.2 1.2 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 EFC50884.1 - 0.00012 21.4 0.0 0.00025 20.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 EFC50884.1 - 0.0021 17.4 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like DUF4135 PF13575.6 EFC50884.1 - 0.02 14.2 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) RIO1 PF01163.22 EFC50884.1 - 0.032 13.8 0.2 0.079 12.6 0.2 1.6 2 0 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 EFC50884.1 - 0.054 13.1 0.4 0.096 12.3 0.4 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 EFC50884.1 - 0.086 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family MACPF PF01823.19 EFC50885.1 - 8.7e-08 32.5 0.1 2.1e-06 28.0 0.1 2.5 1 1 0 1 1 1 1 MAC/Perforin domain BTB PF00651.31 EFC50885.1 - 0.0077 16.5 1.6 0.073 13.3 0.1 2.9 3 0 0 3 3 3 1 BTB/POZ domain DUF3718 PF12514.8 EFC50885.1 - 0.1 12.8 0.1 22 5.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3718) BACK PF07707.15 EFC50885.1 - 0.13 12.4 2.4 0.91 9.7 0.1 2.9 2 0 0 2 2 2 0 BTB And C-terminal Kelch DUF202 PF02656.15 EFC50887.1 - 3.3e-14 53.1 4.1 3.3e-14 53.1 4.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Kinocilin PF15033.6 EFC50887.1 - 0.6 9.8 7.3 2.7 7.6 3.1 3.1 2 1 1 3 3 3 0 Kinocilin protein FAD_binding_3 PF01494.19 EFC50888.1 - 1.9e-23 83.3 0.1 2.6e-22 79.6 0.1 2.2 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 EFC50888.1 - 3.1e-05 23.1 0.0 6.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Squalene epoxidase Pyr_redox_2 PF07992.14 EFC50888.1 - 7.6e-05 22.1 0.2 0.065 12.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 EFC50888.1 - 0.01 15.4 0.2 0.059 13.0 0.2 2.1 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 EFC50888.1 - 0.061 13.6 0.1 0.21 11.8 0.2 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain F420_oxidored PF03807.17 EFC50888.1 - 0.068 13.8 0.3 0.48 11.0 0.2 2.3 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pyr_redox PF00070.27 EFC50888.1 - 0.088 13.4 2.5 2.2 8.9 0.2 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Rep_fac_C PF08542.11 EFC50889.1 - 2.8e-20 72.5 0.2 9.8e-20 70.8 0.2 2.0 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 EFC50889.1 - 1.1e-17 64.8 0.0 2.1e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 EFC50889.1 - 6.5e-16 58.5 0.1 1.2e-14 54.5 0.0 2.5 2 1 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 EFC50889.1 - 5e-10 39.6 0.0 3.6e-09 36.8 0.0 2.1 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 EFC50889.1 - 2.9e-07 30.4 0.0 6.2e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 EFC50889.1 - 1.8e-06 28.0 0.0 3.8e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 EFC50889.1 - 7.3e-06 26.5 0.2 4.2e-05 24.0 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 EFC50889.1 - 8.9e-06 25.6 0.0 1.7e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 EFC50889.1 - 1.7e-05 25.1 0.5 0.0013 19.0 0.4 2.9 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 EFC50889.1 - 2.7e-05 24.2 0.1 8.1e-05 22.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 EFC50889.1 - 4.7e-05 22.7 0.0 9.6e-05 21.7 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 EFC50889.1 - 0.00022 21.0 0.1 0.00061 19.6 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 EFC50889.1 - 0.00024 21.0 0.1 0.00057 19.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 EFC50889.1 - 0.00043 20.8 0.0 0.0011 19.6 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 EFC50889.1 - 0.00059 20.2 0.7 0.017 15.5 0.7 2.3 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 EFC50889.1 - 0.001 18.9 0.3 0.0019 18.0 0.3 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit ResIII PF04851.15 EFC50889.1 - 0.0012 18.9 0.2 0.03 14.3 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 EFC50889.1 - 0.0014 18.0 0.0 0.0024 17.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 EFC50889.1 - 0.0041 17.0 0.0 0.0093 15.8 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 EFC50889.1 - 0.0043 16.5 0.3 0.15 11.4 0.0 2.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 EFC50889.1 - 0.0043 17.2 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 EFC50889.1 - 0.0072 16.3 0.0 0.018 14.9 0.0 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_assoc_2 PF16193.5 EFC50889.1 - 0.0092 16.3 0.0 0.032 14.6 0.0 2.0 1 0 0 1 1 1 1 AAA C-terminal domain TIP49 PF06068.13 EFC50889.1 - 0.0096 15.2 0.0 0.018 14.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 EFC50889.1 - 0.01 15.4 0.0 0.028 14.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 EFC50889.1 - 0.011 15.3 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 EFC50889.1 - 0.023 14.5 0.5 0.39 10.5 0.1 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase TniB PF05621.11 EFC50889.1 - 0.039 13.4 0.1 1.2 8.5 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein DUF4932 PF16286.5 EFC50889.1 - 0.042 13.1 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4932) NACHT PF05729.12 EFC50889.1 - 0.047 13.6 0.1 0.15 12.0 0.1 1.8 1 1 0 1 1 1 0 NACHT domain PhoH PF02562.16 EFC50889.1 - 0.057 12.9 0.0 4.2 6.8 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein RNA_helicase PF00910.22 EFC50889.1 - 0.1 13.0 0.0 0.27 11.6 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DUF3802 PF12290.8 EFC50889.1 - 0.11 13.1 0.1 0.29 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) IstB_IS21 PF01695.17 EFC50889.1 - 0.13 12.0 0.5 0.73 9.5 0.5 2.1 1 1 0 1 1 1 0 IstB-like ATP binding protein EamA PF00892.20 EFC50890.1 - 5.1e-22 78.5 41.1 8.5e-14 51.9 19.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 EFC50890.1 - 1.1e-13 51.2 23.8 1.5e-13 50.8 23.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 EFC50890.1 - 0.0044 16.3 26.1 0.01 15.0 26.0 1.7 1 1 0 1 1 1 1 UAA transporter family ubiquitin PF00240.23 EFC50891.1 - 7.5e-26 89.7 0.5 8.2e-26 89.6 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 EFC50891.1 - 1.5e-12 47.1 1.2 1.7e-12 47.0 1.2 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 EFC50891.1 - 0.0003 20.8 2.0 0.39 10.8 0.1 2.0 2 0 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_2 PF14560.6 EFC50891.1 - 0.00034 21.0 0.6 0.0012 19.3 0.6 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 EFC50891.1 - 0.0031 17.4 0.0 0.0034 17.3 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 EFC50891.1 - 0.045 13.9 0.1 0.15 12.1 0.1 1.9 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 EFC50891.1 - 0.075 13.4 0.3 0.089 13.2 0.3 1.2 1 0 0 1 1 1 0 Ubiquitin-like domain EF-hand_1 PF00036.32 EFC50892.1 - 8.2e-05 21.9 0.1 0.00028 20.2 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 EFC50892.1 - 0.0002 21.8 2.7 0.041 14.3 0.3 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 EFC50892.1 - 0.00057 19.6 0.3 0.011 15.6 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 EFC50892.1 - 0.025 14.4 0.2 0.067 13.0 0.1 1.7 1 1 1 2 2 2 0 EF-hand domain pair IL31 PF15209.6 EFC50892.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Interleukin 31 EF-hand_5 PF13202.6 EFC50892.1 - 0.17 11.5 1.4 0.2 11.2 0.2 1.8 2 0 0 2 2 2 0 EF hand FancD2 PF14631.6 EFC50893.1 - 1.2e-61 208.6 44.0 1.2e-32 112.5 10.4 7.5 2 2 8 10 10 10 5 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 EFC50893.1 - 0.073 13.4 7.4 0.026 14.8 2.0 2.7 2 0 0 2 2 2 0 FANCI solenoid 2 DUF3439 PF11921.8 EFC50893.1 - 0.63 10.0 5.0 2.2 8.2 5.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DnaJ_C PF01556.18 EFC50894.1 - 5.8e-41 140.0 0.4 7.1e-41 139.7 0.4 1.0 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 EFC50895.1 - 7e-17 61.3 0.1 7.7e-17 61.2 0.1 1.1 1 0 0 1 1 1 1 DnaJ domain DUF884 PF05959.11 EFC50895.1 - 0.11 12.2 0.0 0.12 12.0 0.0 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF884) Presenilin PF01080.17 EFC50896.1 - 5.5 5.6 8.0 6.8 5.3 8.0 1.3 1 0 0 1 1 1 0 Presenilin # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 09:41:42 2019 # [ok]